Ocular injuries and trauma
Transcription
Ocular injuries and trauma
ARVO 2015 Annual Meeting Abstracts 540 Ocular injuries and trauma Thursday, May 07, 2015 12:00 PM–1:45 PM Exhibit Hall Poster Session Program #/Board # Range: 6034–6065/B0213–B0244 Organizing Section: Clinical/Epidemiologic Research Contributing Section(s): Anatomy/Pathology, Cornea, Eye Movements/Strabismus/Amblyopia/Neuro-Ophthalmology, Lens, Retina Program Number: 6034 Poster Board Number: B0213 Presentation Time: 12:00 PM–1:45 PM Epidemiology of Ocular Trauma in Changsha, China Sarah Chao Ying Xu1, Wanpeng Wang2, Jessica Chow1, Jessica Maslin1, Nisha Chadha1, Ji Liu1, Baihua Chen2, Christopher C. Teng1. 1 Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT; 2Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, China. Purpose: To evaluate the epidemiology of ocular trauma cases presenting to a tertiary hospital in Changsha, China over an 18 months period. Methods: This retrospective study included 532 patients presenting with eye trauma to The Second Xiangya Hospital of Central South University between Dec 17, 2012 and June 29, 2014. Patient charts were evaluated from the hospital’s electronic medical record system for all hospitalized patients. Results: Of the 532 patients presenting during this 18 month period, 434 (81.6%) were males and 98 (18.4%) females. Overall, open globe injuries had the highest frequency (66.0%, n=351), compared to closed globe injuries (33.1%, n=176), and thermal/chemical injuries (0.9% n=5). 91 patients also had adnexal injuries (17.1%). Of the open globe injuries, corneal penetration was the most common injury (42.2% n=148) followed by intraocular foreign body (26.5% n=93). The average age of all patients was 37.4 ± 20 years (range: 10 months to 87 years). The frequency of ocular trauma peaked in children 10 years of age and younger (15.8%, n=84) and in adults between 40-50 years old (19.6%, n=104). The majority of ocular trauma in children ≤10 years of age was open globe injuries (81%, n=68), with corneal penetration being the most frequent mechanism (58.8%, n=40). Overall, the most frequent cause of ocular trauma was work-related injuries (35.5% n=189) followed by injuries at home (23.3% n=124). During the months of January and February, fire-cracker associated ocular injuries were significantly higher than all other causes (23.8%, n= 31, p<0.001). Ocular trauma occurred more frequently in rural settings (72.6%, n= 386) than in urban settings (27.4%, n=146, p<0.001). Conclusions: The epidemiology of ocular traumas varied by age, gender, urban/rural location and time. We found high rates firecracker associated ocular trauma during the months adjacent to the Chinese New Year festival. Better understanding of the epidemiology of ocular traumas may aid in improved health prevention efforts to minimize eye injuries. Commercial Relationships: Sarah Chao Ying Xu, None; Wanpeng Wang, None; Jessica Chow, None; Jessica Maslin, None; Nisha Chadha, None; Ji Liu, None; Baihua Chen, None; Christopher C. Teng, None Program Number: 6035 Poster Board Number: B0214 Presentation Time: 12:00 PM–1:45 PM Disparities in the Treatment of Open Globe Injuries Katrina Chin Loy1, Augustine Obirieze2. 1Ophthalmology, Howard University Hospital, Washington, DC; 2Surgery, Howard University Hospital, Washington, DC. Purpose: Ocular trauma is an important and potentially preventable cause of vision loss worldwide. Traumatic open globe injury is an ophthalmic emergency involving compromised integrity of the cornea or sclera. In order to ensure the best ocular prognosis and potential for vision preservation or restoration, the standard of care for open globe injuries requires prompt evaluation with initiation of antibiotics and primary surgical wound closure emergently, ideally within 24 hours or injury. Delay in treatment by even a few hours may result in increased risk of poor outcomes. The goal of our study is to further characterize demographics of trauma patients that present with open globe injuries and elucidate potential disparities in receiving the standard of care. Methods: Between 2007 and 2010, 773 trauma centers across the United States submitted information to the National Trauma Databank (NTDB). From that dataset, patients included in the study were those >18 years of age who presented with a diagnosis of open globe injury at a Level I or II Trauma Center. Patients were excluded if they were dead on arrival or died in the emergency room. Patients without data reported for race or gender were also excluded. The primary variable of interest studied was race/ethnicity with covariates including age, gender, mechanism of injury, hospital type, insurance type. Primary outcome examined was time to operating room. All results were analyzed with STATA/MP version 12.0. Results: A total of 10,928 cases in the NTDB met the inclusion criteria. Fifty-nine percent of the patients were White, 22% Black, and 4% Hispanic. The majority of patients were between ages 25 and 44. Compared to Whites, who presented at a mean age of 49-yearsold, Blacks presented on average 8 years younger (p<0.0001) and Hispanics 12 years younger (p<0.0001). Of those patients who presented with open globe injuries, 8,199 patients underwent ocular surgery. Eighty-four percent of surgeries were performed within 24 hours of presentation. The adjusted mean time to surgery was 15 hours for White patients, 20 hours for Black patients and 13 hours for Hispanic patients (p<0.05). Conclusions: Based on this database review, there do exist statistically significant differences between Whites, Blacks and Hispanics in terms of age of presentation for open globe injuries and mean time to surgical evaluation and repair of such injuries. Commercial Relationships: Katrina Chin Loy, None; Augustine Obirieze, None Program Number: 6036 Poster Board Number: B0215 Presentation Time: 12:00 PM–1:45 PM Ocular Trauma Scores in patients with combined open globe injuries and facial fractures at a Level 1 Trauma Center in NYC Kalla A. Gervasio, Brett M. Weinstock, Albert Y. Wu. Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY. Purpose: There is a lack of consistent prognostic data on the visual outcomes of patients with both open globe injuries and facial fractures. The Ocular Trauma Score (OTS) is a system that supplies patients with the likelihood of various visual acuity scores based on initial visual acuity, presence of rupture, endophthalmitis, perforating injury, retinal detachment, and RAPD. The purpose of this study is to assess the predictive value and applicability of OTS in high acuity patients with open globe injuries and facial fractures. Methods: Between January 1, 2000 and June 30, 2012, we identified 25 patients with 28 open globe injuries and facial fractures from the Elmhurst City Hospital Trauma Registry. A comprehensive retrospective chart review was done and statistical analysis was performed. The cutoff for p-value significance was less than 0.05. Results: Average age was 52 (range 18-88) and patients were predominantly male (84%). The majority of patients had an OTS of 1 (84%), and of these patients, 76.2% and 14.3% had final visual ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts acuities of no light perception (NLP) and light perception/hand motion (LP/HM) respectively (p = 0.003). These corresponded to 74% and 15% predicted by the original OTS guidelines (100% sensitive and 100% specific). Independent of OTS score, initial visual acuity and frontal bone fractures were predictive of NLP (p = 0.006 and p = 0.047). Non-blindness was associated with nasal bone fractures (p = 0.047). Final visual outcome had no significant association with time to first surgical intervention (<24 hours or >24 hours). OTS score of 1 was associated with zone 3 eye wound location (p = 0.02), but was not associated with the presence of retinal detachment or vitreous hemorrhage at presentation, despite being one of the criteria included in calculating each score. Conclusions: This study validates the use of Ocular Trauma Scores in high acuity patients with combined facial fracture and open globe injury. In the absence of data to calculate a full OTS, initial visual acuity was the strongest predictor of final visual outcome. With regard to fracture type, frontal bone fracture was predictive of NLP, while nasal bone fracture was slightly protective in regard to final visual acuity. Time until surgical intervention was not predictive of visual outcomes in our cohort. Commercial Relationships: Kalla A. Gervasio, None; Brett M. Weinstock, None; Albert Y. Wu, None Program Number: 6037 Poster Board Number: B0216 Presentation Time: 12:00 PM–1:45 PM Characteristics and outcomes of open globe injuries with clinical optic neuropathy Scott Barb, Avni Patel, Tomasz Stryjewski, Christopher Andreoli, Matthew Gardiner, Simmons Lessell. Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA. Purpose: There is limited published data regarding optic neuropathy in patients with open globe injury. We performed a retrospective chart review of an open globe database to improve our understanding of the characteristics and outcomes of those with clinical optic neuropathy. We hypothesize that the typical mechanism of injury will limit the number of cases of optic neuropathy but that analysis will provide an interesting comparison of those with and without optic neuropathy. Methods: We analyzed data from a large institutional database (Massachusetts Eye and Ear Infirmary Trauma Database) over thirteen years (1999-2012). Patients with open globe injury were included for analysis. Clinical optic neuropathy was determined based on the appearance of the optic nerve head and the presence of an afferent pupillary defect (APD). Statistical analyses (a combination of t-test, chi-square, and Fisher’s exact test) were performed to determine if there were clinical and outcome differences between those with and without clinical optic neuropathy. Results: Of the 893 patients with open globe injury, 13 (1.46%) patients were determined to have clinical optic neuropathy. There was no difference between the age and sex of our two groups (p= 0.83, 0.626). The presence of APD was more common in those with optic neuropathy (p=0.002). There was no difference in the incidence of vitreous hemorrhage, intraocular foreign body, or orbital fracture (p=0.068, 0.428, 0.555). The appearance of stretching of the optic nerve on CT did not predict optic neuropathy (p=0.322). There was no difference between the presenting and best visual acuity (p=0.12, 0.06). However, there was a difference in regards to the incidence of retinal detachment development (p=0.013). Conclusions: The incidence of optic nerve damage in the setting of open globe injury is low as we hypothesized and thus evaluation from a large patient cohort is necessary to determine the significance of characteristics and outcomes in those with and without clinical optic neuropathy. Of the evaluated clinical characteristics, only the presence of an APD could predict the increased likelihood of clinical optic neuropathy. It is surprising that there is no difference between the presenting and best visual acuities in those with and without optic neuropathy. However, it is likely that significant damage to other vital structures such as the cornea and retina limit the visual potential. Commercial Relationships: Scott Barb, None; Avni Patel, None; Tomasz Stryjewski, None; Christopher Andreoli, None; Matthew Gardiner, None; Simmons Lessell, None Program Number: 6038 Poster Board Number: B0217 Presentation Time: 12:00 PM–1:45 PM The visual outcome and prognostic factors in open globe ocular injuries Azusa Fujikawa1, Hirofumi Kinoshita1, Makiko Matsumoto1, Eiko Tsuiki1, Kiyoshi Suzuma2, Takashi Kitaoka1. 1Ophthalmology, Nagasaki University, Nagasaki, Japan; 2Ophthalmology, Kyoto University, Kyoto, Japan. Purpose: To evaluate characteristics and prognostic factors in open globe ocular injuries. Methods: Retrospective study of 59 eyes of 59 patients presented with open globe injuries between September 2008 and March 2014 at Nagasaki University Hospital was conducted. Demographic factors including age, gender, and clinical data such as cause of injury, presenting visual acuity (VA), location of injury, type of injury, lens status, presence of intraocular foreign body, types of required surgeries, and final VA were recorded. Prognostic factors were analyzed by comparing the characteristics of two groups: Light perception (LP) (range between LP-24/20) group and no light perception (NLP) group. According to the classification of Ocular Trauma Classification Group, wound location was classified into three zones. Chi-square test was used to compare presented data. Results: Fifty nine patients (46 LP group, 13 NLP group) were included in this study. The mean age was 56.7± 21.8 years in LP group and 62.3± 21.7 years in NLP group with no statistical difference (P=0.67). According to cause of injury, work-related trauma was the most common one (27 eyes) followed by falls (19eyes). Work-related trauma was significantly common in males (P=0.004), while falls was significantly common in females (P=0.00001). Zone 3 injuries were significantly common in NLP group (P=0.04). All cases of NLP group (100%) presented with rupture globe. Posterior segment intraocular foreign bodies were found in 12 eyes of all patients. Crystalline lens dislocation was found in 11 eyes (5LP, 6NLP with P=0.0003). Poor VA at first visit (P=0.00001), rupture globe (P=0.0026), history of penetrating keratoplasty (P=0.02), and dislocation of crystalline lens (P=0.0003) were considered as poor prognostic factors. Eyes first treated with Pars Plana Vitrectomy (PPV) were significantly more likely to achieve LP or better final vision (P=0.012). Conclusions: Poor VA at first visit, rupture globe, zone 3 injuries, history of penetrating keratoplasty, and dislocation of crystalline lens were considered as poor prognostic factors. PPV had a good prognostic value in open globe injuries associated with posterior segment involvement. Commercial Relationships: Azusa Fujikawa, None; Hirofumi Kinoshita, None; Makiko Matsumoto, None; Eiko Tsuiki, None; Kiyoshi Suzuma, None; Takashi Kitaoka, None Program Number: 6039 Poster Board Number: B0218 Presentation Time: 12:00 PM–1:45 PM Visual outcome of open globe injuries in a rural, Appalachian elderly population Masih Ahmed1, Osama Sabbagh2, John Nguyen1. 1Ophthalmology, West Virginia University, Morgantown, WV; 2West Virginia University, Morgantown, WV. ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts Purpose: According to the 2010 United States census, 19.3% of the population lived in rural areas with those over the age of 65 comprising more than 70% of the group. Previous studies of openglobe injuries (OGI) in urban dwelling elderly patients found poor visual prognosis, and there is a dearth of information for those in rural areas. Our aims are to characterize the nature of OGI and to determine the long-term visual outcome in elderly patients seen at a tertiary center in West Virginia. As ocular trauma is one of the most common preventable public health problems, this knowledge can be used to improve care in this vulnerable population. Methods: Retrospective chart review of patients over the age of 65 seen in the West Virginia University Hospital for OGI between January 2000 and December 2014 was performed. Data including demographics, injury settings, type of injury, exam findings, immediate intervention, and long-term outcome and complications were collected. Descriptive statistical analysis was performed. Results: 49 patients between 65 and 98 years old were identified. 37.2% were male, and 62.8% were female. 87.8% were trauma related, and 12.2% were from surgical wound dehiscence. Of the traumatic cases, the causes were fall (60.5%), yard work injury (16.3%), ATV accident (9.3%), and motor vehicle accident (2.3%). 42.9% involved the right eye. 91.9% occurred at home, and 8.1% happened in nursing facility settings. Over 60% had prior cataract and/or corneal transplant surgery. Initial average visual acuity was 20/812, and 20.4% were NLP. Concurrent adnexal injuries included eyelid lacerations (32.6%) and orbital fractures (16.3%). 100% underwent primary OGI repair within 24 hours of admission. 97.8% underwent primary ruptured globe repair, and 2.2% had primary enucleation. Average follow-up time was 1.4 years. 13.9% underwent subsequent enucleation. Other surgeries included vitrectomy (18.6%), penetrating keratoplasty (9.3%), and retinal detachment repair (6.9%). Final average visual acuity was 20/412, and 25.6% remained NLP. Conclusions: Elderly living in rural Appalachia with traumatic open globe injury have a poor visual prognosis. While fall is the most common cause, yard work and all-terrain-vehicle accidents are more prominent in this population. Implementation of fall prevention programs and proper facial protective equipment may help to decrease these injuries and to maintain continued independence. Commercial Relationships: Masih Ahmed, None; Osama Sabbagh, None; John Nguyen, None Program Number: 6040 Poster Board Number: B0219 Presentation Time: 12:00 PM–1:45 PM Effect of prior ophthalmic surgery and open globe injuries? mohamud A. qadi1, Adrienne Scott1, Jiangxia Wang2, christina prescott1. 1Department of Ophthalmology, Johns Hopkins University School of Medicine Wilmer Eye Institute, Baltimore, MD; 2 Department of Biostatistics, School of Public Health, Johns Hopkins University, Baltimore, MD. Purpose: To review the epidemiology and detect the impact of prior corneal, cataract, retinal, and refractive surgeries on visual recovery in patients with open globe injuries. Methods: We performed a retrospective case review of the Johns Hopkins electronic medical records and found 39,000 ophthalmic surgeries and 4,000 open-globe injuries from January 1, 1997 to November 1, 2014. 400 patients who underwent ophthalmic surgeries had subsequent open globe injuries. 79 patients out of these 400 had prior ophthalmic surgeries for corneal transplant, cataract surgery, retinal surgery, or refractive surgery in the same eye. Gender, age, dates of prior ophthalmic surgeries, date of open-globe injury, initial uncorrected visual acuity (UCVA), initial best-corrected visual acuity (BCVA), type of open-globe injury, location of open- globe injury, cause of open globe-injury, and type of open globe repairs, were evaluated using logistic regression models for final UCVA and final BCVA. Results: A prognostic model for the impact of prior ophthalmic surgeries on open globe injuries was constructed. Multiple logistic models were performed for final visual acuity. The strongest predictive factors for enucleation as a final visual outcome were prior history of corneal transplant surgery, mainly penetrating keratoplasty (PKP) and Descemet’s Stripping Endothelial Keratoplasty (DSEK). The greatest predictors for final best corrective visual acuity (BCVA) of 19/100 to 5/200 were prior history of cataract surgery (phacoemulsification and extracapsular). Conclusions: Patients who have prior corneal transplant surgery may have worse visual outcomes after subsequent open globe injury compared to other types of ophthalmic surgeries. This should be useful in counseling patients and making clinical decisions regarding open globe injury management in patients with prior ophthalmic surgeries. This also demonstrates the importance of appropriate counseling when considering ophthalmic surgical interventions in patients at risk for ocular trauma, especially children. Commercial Relationships: mohamud A. qadi, None; Adrienne Scott, None; Jiangxia Wang, None; christina prescott, None Program Number: 6041 Poster Board Number: B0220 Presentation Time: 12:00 PM–1:45 PM Open globe injuries requiring pars plana vitrectomy at an urban hospital: retrospective review of 10-year experience Tian Xia1, Alain M. Bauza1, 3, Nishant Soni2, Marco A. Zarbin1, Paul D. Langer1, Neelakshi Bhagat1. 1Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ; 2Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD; 3Ophthalmology, Boston University, Boston, MA. Purpose: To describe the characteristics of open globe injuries (OGIs) requiring pars plana vitrectomy (PPV) for posterior segment trauma including epidemiology, presentation, management, outcomes and complications. Methods: Retrospective chart review of PPV after OGI presenting to Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ between 2003 and 2012 was conducted. Data was collected on demographics, clinical presentation, and surgical procedures. Main outcome measures are visual acuity (VA), retinal attachment based on fundascopic exam, and additional retinal surgeries. Chi-square analysis and student t-tests were performed with significance of p <0.05. Results: One-hundred-twenty eyes (mean age, 39 years; 84% male, 16% female) underwent PPV after OGI. They were divided into three groups: 64 (53%) early RD (within 30 days), 30 (25%) delayed RD (after 30 days) and 26 (22%) no RD patients. Injuries were categorized to penetrating (35%, n=43), rupture (50%, n=60), and penetrating injuries with retained intraocular foreign body (IOFB) (14%, n=17). Injuries in Zone I, II and III were seen in 35% (n=40), 34% (n=38) and 31% (n=35), respectively. Ocular trauma scores were statistically significantly different between these groups (p<0.01). Mean presenting and mean final logMAR VA were 2.20± 0.63 and 1.87 ±0.60 respectively (p <0.01) with a mean follow up of 1168 days. Eighty-eight eyes (73%) underwent one PPV, 23 two (19%) PPV, eight three (7%) PPV, and one four (1%) PPV. Final overall anatomic success after surgeries was 98% for early RD, and 95% for delayed RD. Other posterior segment procedures with PPV included scleral buckles (n=13), retinectomy/retinotomy (n=13), and enucleation (n=7). Conclusions: Overall functional and anatomic success for eyes with posterior segment trauma that undergo PPV, are poor and comparable ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts to other studies. Delayed presenting RD may have poorer final visual and anatomic success compared to the eyes presenting with early RD. Further studies are needed to analyze these differences. Commercial Relationships: Tian Xia, None; Alain M. Bauza, None; Nishant Soni, None; Marco A. Zarbin, None; Paul D. Langer, None; Neelakshi Bhagat, None Program Number: 6042 Poster Board Number: B0221 Presentation Time: 12:00 PM–1:45 PM PROGNOSTIC INDICATORS OF FINAL VISUAL ACUITY AFTER OPEN GLOBE INJURY Gareth M. Lema, Henry Lin, Pradeepa Yoganathan. Ophtalmology, University at Buffalo, Buffalo, NY. Purpose: To identify prognostic indicators of postoperative visual acuity and retinal detachment among patients with open globe injuries, as well as to compare our findings to an established algorithm for predicting long-term visual outcomes from ocular trauma. Methods: Retrospective chart review consisting of 54 eyes from 54 adult patients (38 male, 16 female) diagnosed with open globe injury between September, 2011 and March, 2014. Inclusion criteria included full assessment of Ocular Trauma Score criteria (preoperative visual acuity, mechanism of injury, reverse afferent pupillary defect, retinal detachment, and endophthalmitis), as well as data on demographics and other injury characteristics (i.e. zone of injury, lid/adnexal injury, hyphema, vitreous hemorrhage, loss of uveal tissue and traumatic cataract). Multivariate linear regression was used to assess the relationship between potential predictors and postoperative visual acuity (FVA), after adjustment for age, sex, race and preoperative visual acuity (IVA). Logistic regression was used to evaluate the relationship between potential predictors and occurrence of retinal detachment (RD). Results: Mean participant age was 45.6 years, and mean follow-up time was 1.2 years. Blunt trauma accounted for 57.4% (31/54) of injuries. Globe perforation occurred in 14.8% (8/54) of cases, and an intraocular foreign body was present in 20.4% (11/54) of cases. The prevalence of RD was 42.6% (23/54). Mean time to RD was 9.3 days. Relative afferent pupillary defect was observed in 33.3% (18/54) of patients. Only one patient developed endophthalmitis. The base model including IVA accounted for 62.0% of the R2 in FVA. Adding information about RD significantly improved R2 to 70.6%. In comparison, the ocular trauma score accounted for 65.7% of R2 in FVA. No other injury characteristic was associated with FVA after adjustment for IVA. Among patients with 20/200 or worse FVA, 100% (27/27) had IVA of 20/200 or worse, and 70.4% (19/27) also had RD. The same base model including IVA accounted for 38.8% of the R2 in RD. Adding information on vitreous hemorrhage significantly improved R2 to 60.6%. No other injury characteristic was associated with RD after adjustment for IVA. Among patientswith RD, 95.7% (22/23) also exhibited vitreous hemorrhage. Conclusions: IVA and occurrence of RD were the most important prognostic indicators of FVA. IVA and vitreous hemorrhage were significant predictors of RD. Commercial Relationships: Gareth M. Lema, None; Henry Lin, None; Pradeepa Yoganathan, None Support: Unrestricted Grant to the Department of Ophthalmology, State University of New York- University at Buffalo, from Research to Prevent Blindness Program Number: 6043 Poster Board Number: B0222 Presentation Time: 12:00 PM–1:45 PM A 19-Year Experience of Regional Anesthesia for the Surgical Repair of Open Globe Injuries Andrew J. McClellan, Jacquelyn J. Daubert, Harry W. Flynn, Steven Gayer. Ophthalmology, Bascom Palmer Eye Institute, Miami, FL. Purpose: To examine the changes over time in the factors and outcomes of open globe injuries repaired under regional anesthesia (RA), local block with monitored anesthesia care, compared with those repaired under general anesthesia (GA) in salvageable adult eyes. Methods: A retrospective case series of all adult repairable open globe injuries receiving primary repair at the Bascom Palmer Eye Institute between January 1st, 2004 and December 31st, 2013. Cases were identified by a post-operative diagnosis of open globe injury (ICD-9: 360.5, 360.6, 871, or 918.1). Exclusion criteria were patients less than 18 years of age and those treated with primary enucleation. This data was then compared to that collected from our own institution 1995 to 2003 with identical inclusion and exclusion criteria [AJO 2002;134:707-711][OSLI 2005;36:122-128]. Results: 714 eyes met inclusion criteria. There was a high rate of RA use at 79%. This is significantly more frequent than the preceding 10 years; 64% from 1995 to 1999 [p<0.001] and 41% from 2000 to 2003 [p<0.001]. The majority of subjects were male (70%), but there was an insignificant difference in gender between those repaired with RA versus GA [p=0.4]. Age was found to be significantly different between these groups [p<0.001] with the mean age of those repaired under GA being 7 years younger than those repaired with RA (45 v. 53 yrs). This difference was not found during the prior two study periods. No mechanism of injury was any more prevalent in either study group (bunt, sharp, intraocular foreign body, perforating, or mixed) [p=0.6]. Open globe injuries repaired under RA, versus GA, had wounds that were more anterior in location (Zone 1: 60 v. 23%, Zone 2: 29 v. 33%, Zone 3: 11 v. 44%), and smaller in size (8 v. 14 mm) [p<0.001]. These eyes also had better presenting and final logMAR visual acuities (2.13 v. 2.6, and 2 v. 2.58) [p<0.001]. Wound characteristics between the RA and GA group parallel those found between 1995 and 2003 with a trend towards larger and more posterior injuries being repaired with RA in the current study period, though it was not found to be statistically significant. Conclusions: Regional anesthesia is a suitable alternative to the risks of general anesthesia for the repair of open globe injuries in selected patients. Percentage of Regional Anesthesia Use Over 19 Years ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts enucleation; thus, primary enucleation would not be saving these patients from numerous subsequent surgical procedures. We recommend attempting primary closure of traumatic open globes and counseling patients presenting with VA of NLP or unable to assess VA, incomplete primary closure, or posterior laceration that enucleation may be required in the future. Commercial Relationships: Kathryn Ortmann, None; John Anderson, None; Alice Chuang, None; Lauren Blieden, None Support: National Eye Institute Vision Core Grant P30EY010608; Challenge Grant from Research to Prevent Blindness; Hermann Eye Fund Anesthetic Use by Zone Commercial Relationships: Andrew J. McClellan, None; Jacquelyn J. Daubert, None; Harry W. Flynn, None; Steven Gayer, None Program Number: 6044 Poster Board Number: B0223 Presentation Time: 12:00 PM–1:45 PM Primary enucleation in the treatment of traumatic open globe injuries Kathryn Ortmann1, John Anderson1, 2, Alice Chuang1, Lauren Blieden1, 2. 1Ruiz Department of Ophthalmology and Visual Science, The University of Texas Medical School at Houston, Houston, TX; 2 Robert Cizik Eye Clinic, Houston, TX. Purpose: We performed a retrospective chart review to estimate the incidence of traumatic open globes resulting in enucleation, average number of surgical procedures occurring after primary open globe repair, and identify prognostic indicators leading to enucleation. We suspected primary enucleation may save some eyes from multiple surgeries before ultimately undergoing secondary enucleation. Methods: We reviewed charts of patients treated for traumatic open globe injuries over 7 years (2008 – 2014) with at least 3 months of follow-up at the Robert Cizik Eye Clinic. Exclusion criteria include missing data points for presenting visual acuity (VA) or whether the injury was completely closed. Collected data included date of injury, VA at presentation, location of laceration, presence of complete primary closure, presence of intraocular foreign body, date and type of subsequent ocular surgery sessions including enucleation, and VA at last recorded follow-up. Baseline clinical data were summarized by mean or frequency. Logistic regression analysis was used to identify risk factors for enucleation. Results: 711 charts were reviewed and of 190 traumatic open globes that met eligiblity criteria, 52 eyes (27.4%) underwent enucleation. Of those, 25 eyes (48.2%) had primary and 27 eyes (51.9%) had secondary enucleation. Excluding enucleations, 93 eyes (49.0%) had 0 subsequent surgical sessions following primary repair, 86 eyes (45.3%) had 1 to 3 sessions, and 11 eyes (5.8%) had more than 3 sessions. Of the 27 eyes that underwent secondary enucleation, 25 eyes (92.6%) had no additional surgical sessions between primary repair and secondary enucleation, and 2 eyes (7.4%) had one additional surgical session. The odds ratio for requiring enucleation was 10.4 for a presenting VA of no light perception (NLP) (P<0.001), 14.1 for incomplete primary closure (P<0.001), 3.5 for unable to take VA at the presentation (P=0.031), and 2.8 for a posterior laceration (P=0.044). Conclusions: The majority of patients who underwent secondary enucleation had 1 or fewer surgeries between primary repair and Program Number: 6045 Poster Board Number: B0224 Presentation Time: 12:00 PM–1:45 PM Use of intravenous vancomycin and cefepime in preventing endophthalmitis after open globe injury Jason M. Huang, Preston H. Blomquist. Ophthalmology, University of Texas at Southwestern, Dallas, TX. Purpose: Prior studies have investigated the use of intravenous vancomycin and ceftazidime for preventing endophthalmitis after post-traumatic open globe injuries. However, no studies have examined the use of vancomycin and cefepime for this purpose. We performed a retrospective cohort study to determine the rate of endophthalmitis after open globe injury with administration of vancomycin and cefepime. Methods: Charts of all patients (173 in total) who presented to Parkland Health and Hospital System for open globe injury between June 1, 2009 and June 16, 2013 were reviewed. Data collection included time from injury to initial presentation, mechanism of injury, ophthalmological exam details, timing of globe repair, and length of follow-up. All patients were treated with a standardized protocol of vancomycin and cefepime for 48 hours. Open globe surgical repairs were performed by University of Texas Southwestern Department of Ophthalmology faculty members. The primary outcome measure was rate of endophthalmitis, and the secondary outcome measure was risk factors for developing endophthalmitis. Results: Out of 173 patients who presented after open globe injury, 3 patients had signs of endophthalmitis on initial exam prior to starting antibiotics, and 2 patients developed endophthalmitis after initiation of Vancomycin and Cefepime (1.2%). Delayed time from injury to presentation was a risk factor for post-traumatic endophthalmitis (P=0.0001). Association between presence of intraocular foreign body and post-traumatic endophthalmitis was approaching significance (P=0.057). Conclusions: Use of intravenous vancomycin and cefepime for prophylaxis against endophthalmitis after open globe injury resulted in an endophthalmitis rate of 1.2%. Commercial Relationships: Jason M. Huang, None; Preston H. Blomquist, None Support: Research to Prevent Blindness, Inc., New York, NY, USA Program Number: 6046 Poster Board Number: B0225 Presentation Time: 12:00 PM–1:45 PM Ruptured Globe injuries presenting with high IOP associated with poor visual outcomes Hampton Addis, Samantha Uhlfelder, Jordan Margo, Osamah Saeedi. Ophthalmology, University of Maryland School of Medicine, Baltimore, MD. Purpose: Ocular trauma is the leading cause of monocular blindness and a common cause of disability. Low intraocular pressure (IOP) is considered a reliable clinical predictor of open globe injury. However, open globe injury with high IOP has been reported. The goal of this retrospective study was to determine the frequency, clinical ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts characteristics and visual outcomes of patients that present with high IOP and open globe injuries. We hypothesize that there is a significant subset of patients that have high IOP in the setting of globe ruptures and that the visual outcomes in these patients are poor. Methods: A retrospective chart review was performed on globe ruptures presenting to the University of Maryland between 2005 and 2014. Demographics, physical examination, including IOP of the affected and un-affected eye, and follow-up evaluations were analyzed. A masked trauma radiologist re-reviewed available CT scans based on pre-determined radiographic findings. IOP was measured as a continuous variable and univariate and multivariate analyses were performed to determine 1) IOP association with clinical and radiographic variables and 2) predictors of poor visual outcomes. Results: Of 132 eyes presenting with globe rupture, 37 (28%) had IOP recorded. Mean IOP for the affected and unaffected eye were 14 +/- 10.3 mmHg, (range 0-44mmHg) and 16.6 +/- 4.1 mmHg (range 8-16 mmHg), respectively. Six eyes (16.2%) had IOP greater than 21 on presentation. All had uveal prolapse on examination, vitreous hemorrhage on CT scan and a final outcome of no light perception vision. On univariate analysis, risk factors for high IOP included posterior rupture on physical examination (p=0.046), posterior hemorrhage (p=0.025) and intraconal retrobulbar hemorrhage (p=0.035) on CT scan. Final visual acuity light perception or worse vision was also associated with high IOP (P=0.006). On multivariate analysis, high IOP was associated with posterior rupture (p=0.042), and final visual acuity of LP or worse was associated with high IOP (OR =1.49, p=0.049) Conclusions: High intraocular pressure is a frequent finding in patients with ruptured globe injuries and is a poor prognostic factor. High IOP is more likely in patients with posterior rupture and posterior intraocular hemorrhage or intraconal hemorrhage on CT Scan. Commercial Relationships: Hampton Addis, None; Samantha Uhlfelder, None; Jordan Margo, None; Osamah Saeedi, None Program Number: 6047 Poster Board Number: B0226 Presentation Time: 12:00 PM–1:45 PM Risk factors for poor prognosis in patients with penetrating globe injury Rita D. Page1, Sumeet Gupta1, Zeynel A. Karcioglu1, 2. 1 Ophthalmology, University of Virginia, Charlottesville, VA; 2 Pathology, University of Virginia, Charlottesville, VA. Purpose: To identify the risk factors that are predictive of poor prognosis in penetrating globe trauma. Methods: This retrospective case series evaluated 103 eyes that had been surgically treated for an open globe injury from 2007 to 2010 at the Eye Clinic of UVA. There were 64 eyes with at least 6 months of follow-up. The patient population was mostly male (74.1%); age range was 3-88 years. We collected demographics and details of the initial examination, primary repair, office visits, and subsequent surgeries. Four risk factors [pre-operative best-corrected visual acuity (pre-op BCVA), ocular trauma score (OTS), zone of injury (ZOI), and time lapsed between injury and primary repair (TL)] and three outcomes [final best-corrected visual acuity (final BCVA), monthly rate of additional surgeries (MRAS), and enucleation] were identified for analysis. Data were analyzed via univariate and multivariate Spearman rank correlations and univariate and multivariate logistic regression. Results: The patients underwent a total of 159 surgeries, with an average of 2.5 surgeries per patient (range 1-7). 7 patients (10.3%) ultimately underwent enucleation. Pre-op BCVA was positively associated with MRAS, final BCVA, and enucleation. Calculated OTS was negatively associated with the outcome variables. No association was found between TL and ZOI with the outcome variables. Further age and predictor variable adjusted analyses showed pre-op BCVA to be independently positively associated with MRAS (p=0.008) and with final BCVA (p<0.001), while calculated OTS was independently negatively associated with final BCVA (p<0.001), but not uniquely associated with the MRAS (p=0.530). Conclusions: A poor pre-op BCVA is associated with poorer visual acuity outcomes, more additional surgeries, and a higher rate of enucleation. A lower ocular trauma score signifies a more significant injury and is predictive of a worse visual acuity outcome. Zone of injury and time lapsed between injury and repair were not predictive of outcomes. For an open globe patient’s prognosis, pre-op BCVA and OTS are the factors that are most predictive of outcomes. Commercial Relationships: Rita D. Page, None; Sumeet Gupta, None; Zeynel A. Karcioglu, None Program Number: 6048 Poster Board Number: B0227 Presentation Time: 12:00 PM–1:45 PM Perforating wounds observed healthy corneas: a one year observatory report Nicolas Famery, Nicolau Romain, Jean-Louis Bourges, Antoine P. Brezin. Ophthalmology, Groupe hospitalier Cochin Hotel-Dieu, Paris, France. Purpose: Ophthalmic emergencies are numerous pathologies. Some of them impact visual prognosis immediately and need an emergency surgery. Ocular perforating trauma is a part of those emergencies in witch we can found perforating wounds on healthy corneas. There management and there visual outcomes are not well known. We observed this item on a one year period in the ophthalmologic emergency department of Assitance Publique Hôpitaux de Paris (APHP) in Paris (France). Methods: It was a retrospective chart review with all cases of perforating wounds observed on healthy corneas operated between April 1st 2013 and March 31st 2014 in the ophthalmologic emergency department of APHP in Paris (France). Results: On the observed period, 27562 patients underwent an ophthalmologic examination, 40 eyes had a perforating wound, 29 concerned healthy corneas, 1 file was not available for evaluation. Median age was 33 years old (15 to 96). Sex-ratio was 3/1 (21mens/7womens). There was no predominant side of trauma (14 right eyes/14 left eyes). Eight patients had an ophthalmologic preliminary event. Median size of wound was 4.5mm (±3.8mm). Wound was in the central 3mm of the cornea above 8 corneas (29%), linear for 14 corneas (50%), with extraophthamologic involvement for 27 patients (96%). Average initial visual acuity was 0.32 LogMAR, not countable for 16 patients (57%), in witch 3 no light perception (NLP) (19%). Average follow-up was 138 days (±104.8d). Average final visual acuity was 0.24 LogMAR, not countable for 6 patients (21,4%), in witch the half with NLP. Wounds were sutured with an average of 5.4 stiches (1 to 12), needing of 1.6 surgery per patient, average of 5 appointments in the department. Associated trauma were iris trauma (n=17, 17%), traumatic cataract (n=6, 21%), vitreous issue (n=5, 18%), retinal detachment (n=2, 7%), intravitreous hemorrhage (n=2, 7%), retinal or choroidal bleeding (n=2, 7%), scleral wound (n=8, 29%), intraocular foreign body (n=7, 25%), lid or orbit trauma (n=7, 25%). Endophthalmy was not observed. One evisceration was performed during follow-up. Conclusions: When the cornea is healthy before traumatism, a perforating wound allow to obtain an average final acuity better than 0.30 LogMAR but can also be responsible for the loss of visual function in 1 case out of 5. This accident is one emergency examination out of 950. ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts Commercial Relationships: Nicolas Famery, None; Nicolau Romain, None; Jean-Louis Bourges, None; Antoine P. Brezin, None Program Number: 6049 Poster Board Number: B0228 Presentation Time: 12:00 PM–1:45 PM Clinicopathologic Characteristics and Outcomes of Lacerating Injuries to the Eye and Ocular Adnexa at a Tertiary Referral Center Nathan W. Blessing1, Benjamin P. Erickson1, Alexa M. Franco2, Audrey C. Ko1, Sarah Read1, Wendy W. Lee1. 1Ophthalmology, Bascom Palmer Eye Institute, Miami, FL; 2Miller School of Medicine, University of Miami, Miami, FL. Purpose: Lacerating injuries to the eye and ocular adnexa are encountered both in specialty practices and general emergency departments. However, large cohorts of these patients are not typically identified and treated at a single institution. We performed a retrospective observational clinical study to characterize the demographics, mechanisms of injury, clinicopathologic features, and outcomes of such patients at a large tertiary referral center with the aim of refining current management algorithms and improving patient outcomes. Methods: We retrospectively identified patients who presented to the Bascom Palmer Eye Institute over a 12-month period with open wounds of the eye with and without concomitant damage of the ocular adnexa. Patients repaired primarily at an outside facility or with inadequate documentation were excluded. Demographic information, initial and final visual acuity (LogMAR units), clinical examination findings, and length of follow-up were recorded. Results: A total of 100 patients (n=93, 7 excluded) were identified with a mean follow-up time of 325 ± 110 days. A majority of patients were male (78%), under the age of 40 (68%, range 2 – 94), and had right-sided injuries (60%). The most common mechanisms were assault (28%) and workplace injuries (25%). The presence of hyphema, uveal prolapse, vitreous hemorrhage, and Zone 2 or 3 injuries were associated with a decrease in final visual outcome (p<0.05). There was no significant difference in final visual outcome in patients with adnexal lacerations or orbital fractures (p>0.05). Presentation with a traumatic cataract or Zone 1 globe injury portended a better visual outcome (p<0.05). Conclusions: This study provides insights into a population of patients with orbital trauma at a large tertiary referral center. These patients vary widely in their degree of anatomical damage but some clinical findings may be prognostic with regards to visual outcome. In particular, the degree of adnexal damage does not appear to influence the final visual outcome in these patients. In some cases, follow-up was limited due to the patient’s ability to return for local management. Consistent with prior studies, workplace related injuries represent a potential preventable cause of vision loss. No patient in this cohort reported the use of protective eyewear at the time of injury and this remains a key public health concern. Commercial Relationships: Nathan W. Blessing, None; Benjamin P. Erickson, None; Alexa M. Franco, None; Audrey C. Ko, None; Sarah Read, None; Wendy W. Lee, None Purpose: Using a retrospective chart review, the purpose of our study was to determine rate of outpatient follow-up after repair over a 3.5-year period and examine patient demographic, injury, and repair characteristics associated with follow-up compliance. Methods: We reviewed cases repaired at Memorial Hermann Hospital from Jan 2011 through Apr 2014. Injury and repair characteristics including age, insurance status, home address, injury mechanism, repair details, and mental status at time of repair were analyzed. Follow-up was reported as frequency (%). Patient, injury and repair characteristics were summarized by mean (± SD) or frequency (%) by follow-up status and compared using the two-sample t-test or Fisher exact test. Stepwise logistic regression analysis was used to identify the association between follow-up status and patient, injury, and repair characteristics. Results: 218 patients were included. Pediatric patients had a higher percentage of follow-up (71%) than older age groups (57%). Patients with health insurance had a 66% follow-up rate compared to 45% for self-pay patients (P=0.0234). Distance of the patient’s home address from the hospital was not significant. (P=0.6309). Highest follow-up rates were found with patients sustaining blunt trauma not related to assault at 79%. The lowest rate was in patients involved in motor vehicle collisions at 46% (P=0.0025). When analyzing by mental status and presence/absence of drug/alcohol influence at time of repair, we found that 65% of alert and oriented patients followedup compared to 39% of sedated or altered patients (P=0.0125). Patients that were not under the influence of drugs or alcohol had a rate of 68% compared to 36% of patients intoxicated at time of repair (P=0.0002). Higher rates in patients with other ocular injuries were found at 71% compared to patients with isolated lacerations at 43% (P=0.0001). Of patients repaired in the operating room, 76% followed-up compared with 50% repaired at the bedside (P=0.0001). The odds ratios and 95% confidence intervals are shown in the Table 1. Conclusions: Patients were less likely to follow-up if uninsured, intoxicated, or had altered mental status at the time of repair. They were more likely to follow-up if under the age of 18, had concurrent ocular injuries, or had repair performed in the operating room. Overall poor rates of follow-up lead us to recommend absorbable repair materials that do not require removal. Commercial Relationships: Helen Merritt, None; Judianne Kellaway, None; Alice Chuang, None; Lauren Blieden, None Support: National Eye Institute Vision Core Grant P30EY010608; Challenge Grant from Research to Prevent Blindness; Hermann Eye Fund Program Number: 6050 Poster Board Number: B0229 Presentation Time: 12:00 PM–1:45 PM Trends of Outpatient Follow-up after Traumatic Lid Laceration Repair Helen Merritt1, 2, Judianne Kellaway1, 2, Alice Chuang1, Lauren Blieden1, 2. 1Ruiz Department of Ophthalmology and Visual Science, The University of Texas Medical School at Houston, Houston, TX; 2 Robert Cizik Eye Clinic, Houston, TX. ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts Program Number: 6051 Poster Board Number: B0230 Presentation Time: 12:00 PM–1:45 PM Cumulative Effects of Repeated Low-Level Blast on the Optic Nerve in a Rat Model Brian Lund1, Jae Hyek Choi1, Joseph Novak2, Danilo Mendoza1, Teresa A. Bukre1, Peter R. Edsall1, André Akers1, Jeffery M. Cleland1, Anthony J. Johnson1, Heuy-Ching H. Wang1. 1Ocular Trauma, U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, TX; 2 Pathology, U.S. Army Institue of Surgical Reseach, JBSA Fort Sam Houston, TX. Purpose: Visual dysfunction is a common symptom observed in victims of blast-induced traumatic brain injury (TBI). While effects on the brain of primary blast exposure have been extensively studied, less is known about primary blast effects on the eye or visual system. In particular, little is known about the cumulative effects of repeated low-level blast exposure. The purpose of this study is to characterize the effects of repeated low-level blast exposure on the optic nerve using a rat model. Methods: A compressed-air driven shock tube was used to expose Long-Evans rats to blast waves of peak overpressure 68 ± 3 kPa and positive peak duration 2.8 ± 0.1 msec. Rats were divided into groups receiving either a single blast exposure (SBE), SBE after 1hr (SBE+1hr), repeated blast exposure (RBE), control groups (CTR) or CTR with repeated sedations (CTRS). Optic nerves were collected at indicated sampling time points then processed for immunohistochemistry to detect activated caspase 3, ionized calciumbinding adapter molecule 1 (iba-1) and glial fibrillary acidic protein (GFAP). Results: Activated caspase 3 was detected in the optic nerves from RBE and SBE rats, but not in SBE+1hr, CTR and CTRs rats. A significantly higher number of activated caspase 3 positive cells were found in the portions of the optic nerve closest to the eye and optic chiasm in RBE rats than in SBE rats. Activated microglial cells were detected by iba-1 in the optic nerve of all groups. A significantly higher number of iba-1 positive cells were found in the optic nerves of RBE rats. GFAP expression was observed in the optic nerve of all groups. However, a higher level of GFAP was observed in the RBE rats. Conclusions: Low-level repeated blast exposure lead to an increase in apoptosis in the optic nerve as indicated by increased caspase 3 positive cells. Sections of the optic nerve closest to the eye and brain were more susceptible. RBE increased gliosis and activated microglia at the optic nerve . This suggests that there is either a cumulative effect or a delay in healing from repeated low-level blast exposure that may lead to visual dysfunction. Commercial Relationships: Brian Lund, None; Jae Hyek Choi, None; Joseph Novak, None; Danilo Mendoza, None; Teresa A. Bukre, None; Peter R. Edsall, None; André Akers, None; Jeffery M. Cleland, None; Anthony J. Johnson, None; Heuy-Ching H. Wang, None Program Number: 6052 Poster Board Number: B0231 Presentation Time: 12:00 PM–1:45 PM Consumer-product related ocular and periocular trauma in Western Australian children Annette K. Hoskin2, 1, Anne-Marie E Yardley1, 2, Kate Hanman2, 3, Geoffrey Lam1, 3, David A. Mackey2, 1. 1Centre for Ophthalmology and Vision Science, University of Western Australia, Nedlands, WA, Australia; 2Lions Eye Institute, Nedlands, WA, Australia; 3 Ophthalmology, Princess Margaret Hospital for Children, Subiaco, WA, Australia. Purpose: Ocular trauma is a leading cause of monocular blindness in children and consumer products are often the cause. Currently there is a paucity of detailed data on how these injuries occur. We performed a retrospective hospital-based study to identify and characterize consumer product-related eye and adnexal injuries in children admitted to Princess Margaret Hospital for Children (PMH) in Perth, Western Australia, from 2002 to 2013. Methods: A hospital-based retrospective review of children <18 years of age admitted with ocular and periocular trauma from 20022013 was performed. Narrative data were used to assess each case in which a consumer product caused the injury. Demographic data collected, diagnosis, incident location, consumer product category and vision outcomes were analyzed. Results: There were 207 consumer product-related admissions representing 42% of the serious ocular and adnexal injuries identified in the 12-year period. Of these, 56% involved children <5 years (mean age 4.54 years, range 1 month to 15 years old) and 67% involved males. More than 60 different products were implicated; with pieces of furniture the most common (50) followed by toys (36), food products or their containers (22) and stationery items (17). Postinjury visual acuity of worse than 6/18 was recorded in 12% of cases. Kitchen utensils and toys were implicated more often in the injuries with poorer visual outcomes. Conclusions: This study shows that most consumer product-related children’s eye injuries in Perth occur at home in children <5 years old and are predominantly caused by toys, furniture and household products. We must continue to monitor ocular trauma and work closely with legislative and consumer groups to ensure adequate prevention strategies are identified and adopted. Commercial Relationships: Annette K. Hoskin, None; AnneMarie E Yardley, None; Kate Hanman, None; Geoffrey Lam, None; David A. Mackey, None Program Number: 6053 Poster Board Number: B0232 Presentation Time: 12:00 PM–1:45 PM Review of suspected non-accidental head injury cases at Batson Children’s Hospital Ryan Drumright, Bo Huang, Lee Moore. Ophthalmology, University of Mississippi, Brandon, MS. Purpose: Retinal hemorrhage has been reported to occur in association with various types of non-accidental head injury (NAHI). These include subdural hemorrhage (SDH), subarachnoid hemorrhage (SAH), epidural hemorrhage (EDH), and skull fracture. The purposes of this study were to evaluate the association between the presence of retinal hemorrhage and the presence of various types of NAHI and to evaluate the association between the presence of extra-cranial skeletal fracture and retinal hemorrhage. We tested the hypotheses that there would be an association between the presence of retinal hemorrhage and SDH and an association between the presence of extra-cranial skeletal fracture and retinal hemorrhage in patients suspected to be victims of NAHI. Methods: This was a retrospective cross-sectional study of patients less than 5 years of age who were evaluated for NAHI with any of the following diagnoses: SDH, SAH, EDH, or skull fracture. A total of 210 charts were reviewed. After exclusion of 137 patients who did not undergo ophthalmologic examination for suspected NAHI, 73 patients were included in the data analysis. Chi-square testing was used to evaluate the association between the presence of retinal hemorrhage and each specific NAHI diagnosis (SDH, SAH, EDH, and skull fracture) as well as the association between the presence of extra-cranial skeletal fracture and retinal hemorrhage. Results: Forty-one patients had SDH, 13 had SAH, 2 had EDH, and 43 had skull fracture. Twenty-two patients had more than one NAHI diagnosis. Retinal hemorrhage was present in 28 patients (38.4%). The presence of retinal hemorrhage was highly associated with the ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts presence of SDH (p < 0.001), but there was no significant association found with the presence of SAH, EDH, or skull fracture. Extracranial skeletal fractures were present in 15 patients and showed marginal association with the presence of retinal hemorrhage (p = 0.053). Conclusions: Retinal hemorrhages are highly associated with SDH in patients that are suspected to be victims of NAHI, but they are not associated with SAH or skull fracture. These results support a shaking mechanism for the development of these injuries. The number of patients with EDH was too few to draw any conclusions on its association with retinal hemorrhage. Extra-cranial skeletal fractures are more common in NAHI patients with retinal hemorrhage but did not now show a statistically significant association. Commercial Relationships: Ryan Drumright, None; Bo Huang, None; Lee Moore, None Program Number: 6054 Poster Board Number: B0233 Presentation Time: 12:00 PM–1:45 PM The role of visual symptoms in predicting the presence and severity of ocular injury in orbital fractures Juliana Gildener-Leapman, Anne Barmettler. Ophthalmology, Montefiore Hospital/Albert Einstein College of Medicine, Bronx, NY. Purpose: Previous studies have evaluated the frequency of ocular injuries that occur with different types of orbital fractures, but there is a paucity of data regarding the relationship between patient reported visual symptoms and ocular injury in these traumas. This study was designed to assess the reliability of visual symptoms in determining the presence and severity of ocular injuries in the setting of orbital fractures. Methods: This is an IRB approved retrospective chart review of patients with orbital fractures seen in five emergency departments in Bronx, New York over the past year. The following data was collected: patient demographics, visual symptoms, ophthalmologic exam, radiographic findings, along with medical and surgical interventions. Exclusion criteria included age under ten years, altered mental status, or insufficient data. Visual complaints were categorized into new-onset blurry vision, double vision, complete visual obstruction from edematous eyelid, and no visual complaints. The charts were then reviewed for ocular injuries and treatments in patients from each visual subset. Results: A total of 68 patients were evaluated for orbital fractures. Ophthalmology was consulted for 42 of these cases, among which were all 13 patients who reported visual symptoms. Patient subsets included 7 patients with blurry vision, 4 with diplopia, 2 with complete visual obstruction from eyelid edema, and 49 who denied visual symptoms. Patients sometimes had more than one ocular injury. Ocular injuries in those with visual symptoms were as follows: 1 corneal abrasion, 4 extraocular muscle restrictions, 2 iritis, 1 lens dislocation, 1 retrobulbar hematoma, and 1 retinal break. Ocular injuries in those without visual symptoms included: 1 iritis and 1 retrobulbar hematoma. No emergent ocular procedures were needed for patients who denied visual symptoms. Conclusions: Prior studies have not looked at the relationship between patient reported visual symptoms and ocular injury. This study suggests that visual symptoms can be a useful predictor for the presence and severity of ocular injury in orbital fractures. This information may aid in the process of triaging patients for emergent ophthalmologic examination. As not all patients in this study were evaluated by ophthalmology, this may have resulted in an underdiagnosis of ocular injuries. Larger studies in the future could elucidate this further. Commercial Relationships: Juliana Gildener-Leapman, None; Anne Barmettler, None Program Number: 6055 Poster Board Number: B0234 Presentation Time: 12:00 PM–1:45 PM Ocular Examination Findings and Orbital Fracture Locations Predictive of Ocular Injury in Patients with Orbital Fractures Nicholas Behunin, Ingrid U. Scott, Zachary C. Landis, Ana Rubin Panvini. Ophthalmology, Penn State Hershey, Hershey, PA. Purpose: Inpatient ophthalmology consultation is often obtained to rule out ocular injury in the setting of orbital fractures. We performed a retrospective chart review to investigate ocular examination findings predictive of ocular injury in patients with orbital fractures. We also investigated the correlation between orbital fracture location and ocular injury. Methods: Medical records were reviewed of all patients who underwent inpatient ophthalmology consultation to rule out ocular injury in the setting of orbital fracture at Penn State Hershey Medical Center from July 31, 2011 to January 7, 2014. Patients with retinopathy of prematurity or non-accidental trauma were excluded. Data collected include demographics, mechanism of injury, fracture location, ocular examination findings, and ocular injury. Statistical analysis was performed with logistic regression utilizing Firth’s penalized likelihood approach. Results: The study included 203 patients (149 [73.4%] male; 54 [26.6%] female). The most common mechanism of injury was fall (78 total, 38.42%), followed by motor vehicle accident (44 total, 21.67%), and altercation/assault (22 total, 10.84%). Subconjunctival hemorrhage, chemosis, conjunctival injection, abnormal vision, abnormal pupils, and abnormal motility were each independently correlated with the presence of ocular injury (all p < 0.05). Interestingly, eyelid laceration and periorbital ecchymosis were not significantly correlated with ocular injury. Of the fracture patterns studied, only medial wall fracture was significantly associated with ocular injury (odds ratio [OR] 2.699; 95% confidence interval [CI] 1.257, 5.814; p=0.01). The presence of multiple orbital fractures did not significantly correlate with ocular injury. Orbital roof fracture was associated with an increased risk of optic neuropathy (OR 19.8; CI 1.875, 2679.356; p = 0.01). Conclusions: In this study of patients with orbital fracture, subconjunctival hemorrhage, chemosis, conjunctival injection, abnormal vision, abnormal pupils, and abnormal motility were each independently correlated with ocular injury. Of the fracture patterns studied, only medial wall fracture was associated with ocular injury. The presence of multiple orbital fractures was not correlated with the presence of ocular injury. Commercial Relationships: Nicholas Behunin, None; Ingrid U. Scott, None; Zachary C. Landis, None; Ana Rubin Panvini, None Program Number: 6056 Poster Board Number: B0235 Presentation Time: 12:00 PM–1:45 PM The Natural History of Pre-macular Hemorrhage in Infants Christopher R. Stelton, G B. Hubbard. Ophthalmology, Emory University, Atlanta, GA. Purpose: In infants, the management of a very specific pattern of hemorrhage confined to the sub-internal limiting membrane or sub-hyaloid spaces after traumatic shaking injury has not been extensively studied and no consensus among pediatric vitreoretinal surgeons exists as to the optimal timing for surgical intervention. This situation may be difficult for the pediatric vitreoretinal surgeon and the literature offers little guidance. We describe the typical presenting features, management, and visual outcomes of infants after non- ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts accidental trauma with pre-macular hemorrhage. We performed a retrospective, observational case review. Methods: Eligible patients were identified by a computerized search of the Emory Eye Center database. Children with a specific pattern of blood confined to the sub-internal limiting membrane or sub-hyaloid spaces obscuring the macula were included. Relevant information was recorded, including age at time of bleed, visual function, anatomic findings, and associated neurologic history. A total of 22 patients and 36 eyes over a period greater than 12 years were identified. Our main outcome measures were mean time to resolution of blood and other ocular co-morbidities. Results: 30/36 (83.3%) eyes underwent observation. 6/36 (16.7%) eyes had surgical intervention. There was no worsening of visual function documented as compared with presenting vision in the 12 patients who had visual acuity noted at initial consultation and at follow up. 5/12 eyes (41.7%) had improvement in visual function. When observed, the mean time to resolution of the blood was 2.96 months. Once the blood cleared, children suffered lasting ocular co-morbidities (i.e. optic atrophy, separation of the internal limiting membrane, macular pigmentary changes or scar, and strabismus). Conclusions: Most cases of pre-macular hemorrhage do not require surgical intervention. When pre-macular blood is present, it typically clears by 3 months. Visual prognosis is often limited by ocular comorbidities. Pre-macular membranes are common. Some eyes may benefit from pars plana vitrectomy (i.e. large hemorrhages or eyes with significant membranes). Commercial Relationships: Christopher R. Stelton, None; G B. Hubbard, None Program Number: 6057 Poster Board Number: B0236 Presentation Time: 12:00 PM–1:45 PM Persistence of Subretinal Fluid and the Risk of Enucleation in Group D Retinoblastoma Eyes Grace Shih1, Jesse berry1, 2, Stavros Moysidis1, A. L. Murphree2, Rima Jubran2, Jonathan W. Kim1, 2. 1Ophthalmology, University of Southern California, Los Angeles, CA; 2Ophthalmology, Children’s Hospital of Los Angeles, Los Angeles, CA. Purpose: To evaluate the association of persistent subretinal fluid (SRF) and the need for enucleation in Group D eyes of bilateral retinoblastoma treated with chemoreduction. Methods: 53 Group D eyes were evaluated for the presence of SRF at diagnosis. They were subsequently treated with primary chemoreduction, using a 3 drug chemotherapy regimen. Globe survival analysis was used to evaluate whether persistence of subretinal fluid was associated with persistent tumor activity after chemoreduction and a worse overall outcome (i.e. enucleation). Logistic regression analysis was used to assess the association between duration of SRF and risk for enucleation. Results: 79.25% (n=42) of Group D eyes exhibited SRF at diagnosis. Of these 42 eyes, 25 eyes showed subretinal fluid that persisted after the first round of chemotherapy. 9 eyes demonstrated continued SRF after 3 cycles of chemotherapy and 2 eyes continued with fluid at 6 months. Ten eyes ultimately required enucleation (10/53 or 18.9%). Only one of the 10 enucleated eyes demonstrated persistent SRF at the time of enucleation. 8 of 10 eyes contained histologic evidence of viable tumor cells. There was no statistically significant association between the persistence of SRF and risk for enucleation. Conclusions: We hypothesized that the persistence of subretinal fluid during chemotherapy was a risk factor for enucleation. However, the duration of SRF was not found to be an independent predictor of whether Group D eyes will ultimately require enucleation following chemoreduction. Commercial Relationships: Grace Shih, None; Jesse berry, None; Stavros Moysidis, None; A. L. Murphree, None; Rima Jubran, None; Jonathan W. Kim, None Support: An Unrestricted grant from Research to Prevent Blindness, New York, NY 10022 Program Number: 6058 Poster Board Number: B0237 Presentation Time: 12:00 PM–1:45 PM Rescue Intra-Arterial Chemotherapy Following Retinoblastoma Recurrence After Initial Intra-Arterial Chemotherapy Renelle Pointdujour Lim1, 2, Emil A. Say1, 2, Christopher Cao1, 2, Carol L. Shields1, 2. 1Ocular Oncology, Wills Eye Hospital, Philadelphia, PA; 2 Thomas Jefferson University Hospital, Philadelphia, PA. Purpose: To determine the efficacy of rescue intra-arterial chemotherapy (IAC) for tumor recurrence after previous IAC for retinoblastoma. Methods: Retrospective interventional case series of 12 patients treated with repeat (rescue) IAC for tumor, subretinal seed or vitreous seed control after previous IAC for retinoblastoma. Results: Median age at presentation was 16 months and 8 were female. The initial International Classification of Retinoblastoma was group B (n=1), group D (n=7), and group E (n=4). In all cases, initial IAC was delivered at Thomas Jefferson University Hospital or elsewhere using M3 (n=3) or M5 (n= 7), M5+T1 (n=2) median 3 cycles (range 1-4). Of the 12 patients, 17% (n=2) had the opposite eye previously enucleated so the rescue IAC was planned for the only remaining eye. Rescue IAC was delivered for recurrent solid tumor (n=1) recurrent extensive subretinal seeds (n=7), recurrent extensive vitreous seeds (n=1), or for combination recurrent subretinal and vitreous seeds (n=3). The median interval between final cycle of initial IAC to first cycle of rescue IAC was 4 months (range 2-10 months). IAC was successful through the ophthalmic artery (10/12, 83%) or through the middle meningeal artery (2/12, 17%) when ophthalmic artery obstruction was present from initial IAC elsewhere. Each case received median 3 IAC cycles of Melphalan alone (4/12, 33%) or combination Melphalan and Topotecan (8/12, 67%). At median follow-up of 7 months (range 3-31 months), complete tumor control was achieved in 10 eyes (83%) and globe salvage in 9 eyes (75%). Three eyes underwent enucleation for persistent subretinal seeds (n=2) or neovascular glaucoma without viable tumor on histopathology (n=1). There was no case of cerebrovascular stroke, systemic metastasis, or death. Conclusions: Rescue IAC following tumor recurrence after initial IAC provided 83% tumor control and 75% globe salvage in this series. ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts Regression of subretinal seeds after rescue intraarterial chemotherapy. (A) Retcam photograph upon presentation with total retinal detachment secondary to a large exophytic retinoblastoma. (B) Main tumor regression after 3 sessions of intraarterial Melphalan 5mg. (C). Recurrent subretinal seeds at the superior arcade and (D) in the inferior peripheral retina. (E & F) Complete regression of the subretinal seeds after rescue intraarterial chemotherapy using Melphalan 5mg and Topotecan 1mg. Commercial Relationships: Renelle Pointdujour Lim, None; Emil A. Say, None; Christopher Cao, None; Carol L. Shields, None Program Number: 6059 Poster Board Number: B0238 Presentation Time: 12:00 PM–1:45 PM Success rates of intravenous chemotherapy for intraocular retinoblastoma: A meta-analysis Anthony B. Daniels5, 2, Shriji Patel1, Tatsuki Koyama4, 2, Joann Alvarez4, 2, Debra L. Friedman3, 2. 1Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, TN; 2Vanderbilt-Ingram Cancer Center, Nashville, TN; 3Division of Pediatric Hematology/Oncology, Department of Pediatrics, Vanderbilt University, Nashville, TN; 4 Department of Cancer Biostatistics, Vanderbilt University, Nashville, TN; 5Departments of Ophthalmology and Cancer Biology, Vanderbilt University, Nashville, TN. Purpose: To analyze the reported success rates for intravenous chemotherapy for the treatment of intraocular retinoblastoma (RB), based on classification group and chemotherapy regimen. Methods: PubMed was searched for English articles containing the words “retinoblastoma” and “chemotherapy”, yielding 2329 papers. In vitro/genetic studies (n=1119), animal studies (n=291), studies unrelated to retinoblastoma treatment (n=473) or using a different treatment modality (n=137) were excluded. Case reports/small series (n=114) and editorials (n=108) were excluded. Thus, 87 studies met our inclusion criteria. Success was defined as globe retention without salvage external beam radiotherapy (EBRT). Studies with planned EBRT were excluded. Studies in which eye classification (Reese- Ellsworth [R-E] or International Classification of Retinoblastoma [ICRB]) could not be determined were excluded, as were papers in which it was not possible to identify which eyes avoided both EBRT and enucleation. Duplicate papers reporting on previously published cohorts of patients were excluded. This yielded 23 studies included in this analysis. Weighted point estimates and 95% confidence intervals for success rates by classification group were calculated. We also assessed for different success rates based on chemotherapy regimen and focal treatment and created a model based on these variables. Results: Weighted estimates of globe salvage rate with chemoreduction were 83% (95%CI: 67-92%) for R-E Group 1 eyes, 76% (95%CI: 66-84%) for Group 2 eyes, 67% (95%CI: 53-78%) for Group 3 eyes, 49% (95%CI: 36-63%) for Group 4 eyes, and 38% (95%CI: 28-49%) for Group 5 eyes (39% [95%CI: 24-57%] for 5A eyes and 46% [95%CI: 34-59%] for 5B eyes). Using the ICRB, weighted globe salvage rates were 93% (95%CI: 79-98%) for Group A eyes, 83% (95%CI: 71-91%) for Group B, 74% (95%CI: 50-89%) for Group C, 40% (95%CI: 30-52%) for Group D, and 24% (95%CI: 9-52%) for Group E. No statistically-significant difference between chemotherapy regimens was detected. Conclusions: Reporting of outcomes in retinoblastoma is not standardized. There is significant selection bias in many studies, as worse eyes are more likely to be enucleated primarily without an attempt at chemoreduction. Both R-E and ICRB predict chemoreduction success. New techniques such as intra-arterial and intravitreal chemotherapy should be compared to these historical success rates of IV chemotherapy. Commercial Relationships: Anthony B. Daniels, None; Shriji Patel, None; Tatsuki Koyama, None; Joann Alvarez, None; Debra L. Friedman, None Program Number: 6060 Poster Board Number: B0239 Presentation Time: 12:00 PM–1:45 PM Customized Iris Prosthesis in eyes with post-traumatic aniridia Anja Nessmann, Julia Wagner, Efdal Yoeruek, Karl U. Bartz-Schmidt, Peter Szurman, Martin S. Spitzer. University Tuebingen Eye Center, Tuebingen, Germany. Purpose: Posttraumatic partial or total iris defects often cause significant debilitating glare, photophobia, decreased vision and cosmetic problems. Currently the best cosmetic results can be obtained with a customized silicone iris prosthesis. However, little is known about the functional results and the rate of complication if this type of iris prosthesis is implanted into severely traumatized eyes. Methods: A consecutive series of 36 patients that received a customized silicone iris prosthesis after severe globe injury with total or sub-total iris loss was analyzed retrospectively. In 18 patients, the iris prosthesis insertion was combined with intraocular lens implantation and in 4 patients with corneal transplantation. Mean visual acuity prior to iris prosthesis implantation was 1.1 logMAR units (0.3 – 2.6 logMAR units). Median follow-up was 17.5 months. 3 patients had preexisting glaucoma and 8 patients hypotony. Results: Postoperative results showed a rather diverse picture. Visual acuity 12 months after surgery was 1.4 LogMAR units (0.2 – 2.6 logMAR units). Patient`s satisfaction increased by reducing glare and enhanced cosmetic appearance. Complications were an increase of intraocular pressure (IOP) requiring new or more pressure lowering therapy in 3 patients, persisting intraocular inflammation or macular edema in 14 patients, and corneal endothelial decompensation (CED) in 5 patients. Moreover, in 5 other cases penetrating keratoplasty was necessary during or after iris prosthesis implantation as a consequence of corneal scarring due to the initial trauma. Conclusions: The customized silicone iris prosthesis is an individualized treatment approach, which can be tailored to distinct ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts eye properties. Therefore, especially trauma eyes with highly different posttraumatic conditions could benefit. In addition, the customized silicon iris prosthesis is a favorable cosmetic solution for the reconstruction of the iris in posttraumatic eyes. However, in some patients the implantation of this device may cause an increase of IOP, corneal endothelial decompensation or persisting inflammation. Thus, the risks of benefits of implantation must be weighed carefully in patients with high or low IOP as well as pre-existing corneal endothelial damage. Commercial Relationships: Anja Nessmann, None; Julia Wagner, None; Efdal Yoeruek, None; Karl U. Bartz-Schmidt, None; Peter Szurman, None; Martin S. Spitzer, None Program Number: 6061 Poster Board Number: B0240 Presentation Time: 12:00 PM–1:45 PM A case series of automobile wing (side) mirror ocular injuries Donovan N. Calder1, 2, Ivor crandon1, Jennifer calder3, 4, Nicole Meeks-aiken1. 1Surgery, University of the West Indies, Kingston, Jamaica; 2Ophthalmology, Mount Sinai, Toronto, ON, Canada; 3 Epidemiology and Community Health, New York Medical College, Valhalla, NY; 4Epidemiology, Columbia University, New York, NY. Purpose: Traffic-related injuries are estimated to become the fifth leading cause of the global burden of diseases by 2020. A 2008 showed that although responsible for 3.3% of all emergency department eye injury visits, traffic-related injuries were responsible for 19.1% of these visits that required hospitalization. The motor vehicle industry has been responsive to the safety needs of drivers and passengers, however studies related to wing mirror related ocular injuries are few. This is the largest case series to date that assesses the severity of wing mirror related ocular injuries. Methods: From January 1996 to December 2005 patients were recruited from two ophthalmology clinics and a trauma registry. Demographic, driving history, vehicle-specific, and clinical data were collected. An ocular injury was any disruption in the integrity of the eye or surrounding orbital structures. Eyebrow or eye lid lacerations or corneal abrasions were considered minor injuries, all other injuries were considered to be major and were classified according to the Birmingham Eye Trauma Terminology System (BETTS). Visual acuity (VA) at presentation and outcome was based on Recommendations of the WHO Consultation on “Development of Standards for Characterization of Vision Loss and Visual Functioning” for monocular vision. All patients underwent slit lamp examination and were treated with as appropriate. Data were analyzed using SAS 9.4 Results: 39 patients had 41 eye injuries (Table 1). Seven of 39 (17.9%) patients had minor injuries. The remaining 32/39 (82.0%) patients had at least one major eye injury which was classified using BETTS (Figure). In persons experiencing minor vs. major injuries there was a statistically significant difference in the mean ages at which driver’s licence was obtained (p=0.0184) and the accident occurred (p=0.0177), and years of driving experience (0.0314). The VA at presentation was associated with that at outcome (p=<0.0001). Only 38% of persons who were categorized as blind at presentation had improved VA at outcome. Conclusions: While wing mirror-related ocular injuries are rare, we show that many cause permanent blindness. Great strides have been made in improving automobile safety, however few standards exist for wing mirrors and even these need review. We propose a larger study to assess the risk factors for wing mirror-related ocular injuries and to develop an international automotive standard. Commercial Relationships: Donovan N. Calder, None; Ivor crandon, None; Jennifer calder, None; Nicole Meeks-aiken, None Program Number: 6062 Poster Board Number: B0241 Presentation Time: 12:00 PM–1:45 PM Outcomes and Prognostic Factors in Patients with Traumatic Corneal Foreign Body Injuries: a review of 387 cases Amy M. Cherof, Jeffrey B. Kennedy, Ronald Wise. Ophthalmology, University of Colorado, Denver, CO. Purpose: To evaluate outcomes and identify prognostic factors in patients with traumatic corneal foreign body injuries. Methods: A retrospective chart review was performed of all patients with traumatic corneal foreign body injuries treated by one corneal specialist at the University of Colorado Department of Ophthalmology, from January 8, 2008 through November 6, 2013. The primary outcome of the study was visual acuity, with a poor outcome defined as loss of one or more lines of Snellen visual acuity or a final best corrected visual acuity worse than 20/40 at final follow up. Patient demographics, injury characteristics and treatment methods were recorded and analyzed in order to assess the potential relationship to visual outcome. Results: A total of 534 consecutive cases were reviewed, of which 387 were included in the study. Overall, 9.8% of patients had a poor outcome. Improvement in Snellen acuity by 1 or more lines was seen in 66.9% of patients. Time to presentation, foreign body location, foreign body material, removal method, and post removal patching or bandage contact lens use were not associated with a significant difference in patient outcomes. Treatment with fluoroquinolone antibiotics after foreign body removal was associated with a statistically significant reduction in poor outcomes (p=0.0198), as was delayed treatment with topical steroids (OR 0.427, p=0.0298). ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts Conclusions: The incidence of poor outcomes is low in patients suffering from a corneal foreign body injury. Patients should be treated with fluoroquinolone antibiotics and delayed topical steroids following foreign body removal in order to reduce the incidence of poor outcomes. Commercial Relationships: Amy M. Cherof, None; Jeffrey B. Kennedy, None; Ronald Wise, None Program Number: 6063 Poster Board Number: B0242 Presentation Time: 12:00 PM–1:45 PM Outcomes of Traumatic Injury with Posterior Intraocular Foreign Bodies Lekha Mukkamala1, Nishant G. Soni2, Paul D. Langer1, Marco A. Zarbin1, Neelakshi Bhagat1. 1Department of Ophthalmology & Visual Sci, New Jersey Medical School-Rutgers University, Newark, NJ; 2 Ophthalmology, University of Maryland Medical Center, Baltimore, MD. Purpose: Penetrating eye trauma with posterior chamber (PC) intraocular foreign bodies (IOFB) may cause devastating sequelae of loss of vision or globe. In this retrospective chart review we aim to describe the presenting features, management, and outcomes of eyes with PC IOFB. Methods: Chart review of patients with PC IOFB who presented to IOVS from 2003-June 2014 was conducted. Patient demographics, type of injury and IOFB, presenting exam [i.e. visual acuity (VA), Ocular Trauma Score (OTS), status of vitreous hemorrhage (VH) and retinal detachment (RD)], surgery and post-operative outcomes were analyzed. Numerical VA was calculated using LogMAR scale. Significance was based on p<0.05 with power of at least 80%. Results: Thirty one patients (28 males, 3 females; mean age 37 years) were identified. Type of IOFB is shown in Figure 1 and was diagnosed by CT in 67%. Most eyes had Zone 1 entry and OTS of 3 or 4 (8 and 7 respectively). One eye presented with endophthalmitis 6 days after injury. Mean follow up time was 17 months (range <1 to 84 mo). PC IOFB was removed within 24 hours of presentation in 28 of 31 patients. One patient opted for no removal and in 2 cases cilia were found 4 and 6 days later during RD repair. Characteristics of patients based on retinal status on presentation are shown in Table 1. RD was repaired with silicone oil tamponade in 56% of cases, with recurrence noted in 35% (Table 1). All patients received IV antibiotics during a mean hospital stay of 4 days; 3 also received intravitreal antibiotics (1 with endophthalmitis on presentation, 2 for prophylaxis). Mean presenting VA was CF; mean final VA was 20/200. Sixty percent of patients achieved VA predicted by OTS (3 better and 5 worse than expected). There was no correlation between initial and final VA (r2=0.11). Patients with RD on presentation had worse final VA than patients with no RD (p<0.05) (Table 1); however power was not adequate to prove significance. The most common complication was RD. One patient in which a second IOFB (cilia) was found 6 days later developed sympathetic ophthalmia. There were no cases of post-operative endophthalmitis. No eyes were enucleated. Conclusions: Patients with posterior IOFBs have guarded visual prognosis, especially when presenting with concurrent RD. Final VA is well predicted by the OTS. Enucleations are rare. Figure 1. Type of PC IOFB Table 1. Characteristics of patients by retinal status on presentation Commercial Relationships: Lekha Mukkamala, None; Nishant G. Soni, None; Paul D. Langer, None; Marco A. Zarbin, None; Neelakshi Bhagat, None Program Number: 6064 Poster Board Number: B0243 Presentation Time: 12:00 PM–1:45 PM Surgical and visual outcomes in traumatic cataract following phacoemulsification, in a mexican pediatric population Pablo J. Guzman-Salas, Ivo Ferreira-Rios, Humberto Matiz-Moreno, Marisol Garzon, Eduardo Chavez-Mondragon. Anterior Segment, Instituto de Oftalmologia - Conde de Valenciana, Mexico City, Mexico. Purpose: Report the number of pediatric patients with traumatic cataracts, attending a reference center in Mexico City, to analyze different epidemiologic characteristics, and their surgical and visual outcomes. Methods: Retrospective, observational case series study was performed. We reviewed clinical data from January 1st 2013, to December 1st 2014. Clinical electronic records were reviewed of patients with diagnosis of Traumatic Cataract, with ages from 0 to 17 years and 364 days. Patient record had to comply with this diagnostic: history of trauma to the eye, with development of cataract, and further surgical intervention, with a minimum of 1 year of follow up. Information from clinical records: gender, age, medical history, type of trauma, residence, time between trauma and surgery, visual acuity in all visits, findings in exploration, axial length, type of surgery and complications, final refraction, capsular bag opacification, need of referral to other Departments. Results: We analyzed 22 patients. Average age was 9.55 ± 4.16 years. Six female (27.3%) and 16 males (72.7%). 1 patient (4.6%) had history of previous disease. 6 patients (27.3%) had open-globe penetrating injury, and 16 patients (72.8%) had closed-globe blunt trauma. 8 patients (36.3%) lived in the city, while 14 (63.7%) lived in rural communities. Time between trauma and surgery: average of 3.99 ± 7.43 months. Visual acuity in first visit: 5 patients (22.8%) with light perception, 10 (45.5%) with hand movement, 5 (22.8%) with an average of 1.78 ± 0.83 logMAR. At one-year follow up, 1 ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected]. ARVO 2015 Annual Meeting Abstracts (4.6%) patient had no light perception; two (9.1%) hand movement. The rest, average of 0.35 ± 0.43 logMAR. Axial length average: 22,86 ± 1.09mm. All patients underwent phacoemulsification, in 21 (95.6%) surgeon was able to place an IOL, and 1 patient (4.6%) was left in aphakia. Capsular bag opacification developed in 4 patients (18.2%). In 20 (91%) the final refraction was obtained, with a mean spherical equivalent of -0.41 ± 0.84 D. 6 patients (27.3%) had to be referred to another Department. Conclusions: Traumatic cataract had higher prevalence in male children, with predominant blunt trauma, from rural communities. Most achieved vision at 1 year follow up better than 0.35 logMAR. This shows us better ways to understand the approach to traumatic cataracts in children, with an ultimate goal to give better quality of life. Commercial Relationships: Pablo J. Guzman-Salas, None; Ivo Ferreira-Rios, None; Humberto Matiz-Moreno, None; Marisol Garzon, None; Eduardo Chavez-Mondragon, None Program Number: 6065 Poster Board Number: B0244 Presentation Time: 12:00 PM–1:45 PM Treatment options for pediatric traumatic cataract Dora Kovacs, Zsolt Biro. Department of Ophthalmology, University of Pécs, Pécs, Hungary. Purpose: Controversy exists regarding the best possible treatment options for pediatric traumatic cataract cases. Our goal was to retrospectively analyse the results of traumatic cataract cases in children treated at our department. Methods: At the Department of Ophthalmology, University of Pécs, Faculty of Medicine, Hungary, 31 patients were treated under the age of 18 with the diagnosis of traumatic cataract between 1998 and 2014. The mean age at the time of treatment was 8,88 years. 74,2% of our patients were male, 25,8% female. Results: Sixty-five percent of our patients suffered penetrating/ perforating eye injury and 35% suffered blunt trauma in one eye. In 16% of the cases intraocular foreign body was also present. Due to patients’ or caretakers’ negligance only 50% of the patients were treated within 24 hours after the trauma. The primary treatment consisted of corneal or scleral wound closure with sutures and extraction of the cataractous lens. 3 patients required a simultaneous pars plana vitrectomy, and iris reposition. Primary IOL implantation was performed in 6 cases and secondary implantation in 13 cases. Postoperative complications included iritis fibrinosa and retinal detachment in 6%, hyphema, epiretinal membrane and endophthalmitis in 3% of the cases. Postoperative care included topical antiinflammatory agents and amblyopia treatment when it was necessary. A postoperative best corrected visual acuity of 0,6 or better was achieved in 35% of the cases. Conclusions: Treatment of pediatric traumatic cataract requires a complex approach. With meticulous surgical techniques, postoperative antiinflammatory and amblyopia treatment satisfactory visual functions may be achieved even after severe trauma to the eye. Commercial Relationships: Dora Kovacs, None; Zsolt Biro, None ©2015, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Office at [email protected].