Encapsulated LipoSan Ultra

Transcription

Encapsulated LipoSan Ultra
Natural Fibers from the Pristine Icelandic Waters
Hélène L. Lauzon, R&D Director
What are they?
Where from?
What for?
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Primex is an Icelandic Marine Biotech Company
A Global Leader in the Manufacture and Supply of
Pure and High Quality Chitosan
Adding value - by nature
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Raw Material
•Chitin from coldwater shrimp shell “Pandalus borealis”
 wild caught in the North Atlantic Ocean
 further processed into chitosan
“Origin of Iceland”
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Quality Systems
To ensure the safety of the production, Primex
runs a documented and controlled Quality System
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HACCP - Quality Assurance System
ISO 22000 – Food Safety Management System
Certified Nature Product
Full analysis and traceability of each batch
Self-sustainable utilisation of natural resources
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Primex’ strength is to supply the purest
available high quality chitosan in the
market: ChitoClear®
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Pure source
High technical production
Low heavy metal content
Low bio-burden content
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What is chitosan?
• Deacetylated form of chitin, a natural fiber
• Most abundant naturally occurring amino-polysaccharide
• Unique physiochemical characteristics and biological activities
• Origin and process influence chemical and physical properties
• Chitin is insoluble in aqueous media
• Chitosan soluble in acidic conditions
→ Due to protonation (NH3+)
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Hydroxyl groups for interactions
 BIOACTIVE COMPOUND
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What is so special about chitosan?
• Important biological properties
 Biocompatible, biodegradable, non-toxic
 Analgesic, antitumor, hemostatic
 Mucoadhesive, film-forming, permeation enhancing
 Fat-binding, anticholesterolemic
 Antimicrobial, antioxidant
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What can chitosan do for you?
• Dietary supplement and functional ingredient
 Weight management
 Biopreservative, emulsifier, processing aid
• Biomedicine
 Hemostatic and wound healing
 Tissue-engineering scaffolds
 Drug delivery
• Personal care and cosmetics
• Several other applications:
41biocatalysis
 Textile, wastewater treatment, metal reduction,
Chitosan in Weight Management
• Obesity problem worldwide; humans and pets
• Several health problems related to obesity
• Chitosan can bind lipids in the stomach
– Decreasing fat digestion
– Reducing caloric uptake
– Contributing to weight and cholesterol control
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Primex solution:
 rapid solubilisation in stomach acid
LipoSan Ultra® is a patented chitosan product including succinic acid, a GRAS food
additive.
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Safe and effective weight loss supplement
More granular in texture / better flow properties
Higher tap density than regular chitosan
Superior fat binding capacity
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The Natural Way of Weight Control
Chitosan must be completely dissolved in stomach acid
in order to effectively bind and block fat.
LipoSan Ultra® is
• Fast acting – dissolves in 3-5 min
• More effective fat binding than
generic chitosan products
• Cholesterol (LDL) lowering agent
• Clinically proven weight loss
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Alternative Uses of LipoSan Ultra®
• Dietary supplement: capsules, tablets
– For humans at mealtime:
Clinical study with 59 overweight women
 Non-restrictive diet for 8 weeks +/- LipoSan Ultra®
 Significant weight loss (1 kg) compared to
1.5 kg weight gain in placebo group
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For pets before or at a meal:
 Added as a top dressing on dry food or mixed with food
 LipoSan Ultra® chewable tablets as a treat before eating
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Alternative Uses of LipoSan Ultra®
• Encapsulated LipoSan Ultra®
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The only chitosan weight management product suitable for beverages and other ready-to-use foods
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Encapsulation remains in weak acid food, but breaks down in the stomach – for active fat
absorption
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New market opportunities for convenient functional foods
Vitafoods Europe 2013 – Best New Product:
Selected as one of the finalists for the
Nutraceuticals Business & Technology Awards
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Important markets for high quality ChitoClear:
Biomedical – Wound healing – Cosmetics – Personal care
• Need for natural solutions
– To combat pathogens resistant to conventional drugs
– As biocompatible and biodegradable polymers
– To replace synthetic compounds
• Studies have shown that ChitoClear® chitosan
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Is not a skin sensitizer; non-allergenic
Reduces bleeding and wound infection
Enhances healing
Can treat wet eczema in animals
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Wound healing gel & spray
Case studies on animals
By Ulrike Koch, DVM, Tierärztliche Klinik Oerzen
ChitoClear gel used in various, predominantly old, non-healing, contaminated
wounds, where other therapies had failed:
 Good healing properties and useful in contaminated as well as old and chronic wounds
 Reduced infection, with anti-itching and anti-inflammatory properties
 Prevented scarring
7-yrs boxer: 8-week
ointment treatments
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Healed 12 days after
use of ChitoClear gel
Primex commercialised product brands
suitable for your applications:
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Thank you
[email protected]
STUDIES MENTIONED:
R.N. Schiller, E. Barrager, A.G. Schauss, E.J. Nichols (2001) A randomized,double-blind, placebo
controlled study examining the effects of a rapidly soluble chitosan dietary supplement on
weight loss and body composition in overweight and mildy obese individuals. J. Amer.
Nutrac. Ass. 4(1): 42-49.
C. Oddsdóttir (2009) Extensive Injury to the Hock of a Mare. Report submitted to Primex by Dr.
Charlotta Oddsdóttir DVM, Iceland, 6 p.
U. Koch (2010) Experience with ChitoClear chitosan as a wound healing gel. Report submitted to
Primex by the Tierdrztliche Klinik Oerzen, Germany, September 2010, 32 p.
G. Arcelin (1999) RCC Project 729854 – Primex Chitosan: Contact Hypersensitivity in Albino
Guinea Pigs, Bühler Test. Report submitted to Primex Ingredients ASA by RCC Ltd, Switzerland,
19.09.99, 42 p.
I.T. Harvima, M. Lyyra, E. Sarkkinen, N. Tapola, R.J. Harvima (2002) Evaluation of chitosan as
possible compound causing immediate hypersensitivity reactions. Report submitted to
Primex ehf by Oy Foodfiles Ltd., Finland, 15.03.02, 29 p.
M. Burkatovskaya, G.P. Tegos, E. Swietlik, T.N. Demidova, A.P. Castano, M.R. Hamblin (2006) Use of
chitosan bandage to prevent fatal infections developing from highly contaminated wounds
in mice. Biomaterials 27(22): 4157-4164.
J.P. Malmquist, S.C. Clemens, H.J. Oien, S.L. Wilson (2008) Hemostasis of oral surgery wounds
with the Hemcon Dental Dressing. J. Oral Maxillofacial Surg. 66(6): 1177-1183.
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