Encapsulated LipoSan Ultra
Transcription
Encapsulated LipoSan Ultra
Natural Fibers from the Pristine Icelandic Waters Hélène L. Lauzon, R&D Director What are they? Where from? What for? 34 Primex is an Icelandic Marine Biotech Company A Global Leader in the Manufacture and Supply of Pure and High Quality Chitosan Adding value - by nature 35 Raw Material •Chitin from coldwater shrimp shell “Pandalus borealis” wild caught in the North Atlantic Ocean further processed into chitosan “Origin of Iceland” 36 Quality Systems To ensure the safety of the production, Primex runs a documented and controlled Quality System • • • • • HACCP - Quality Assurance System ISO 22000 – Food Safety Management System Certified Nature Product Full analysis and traceability of each batch Self-sustainable utilisation of natural resources 37 Primex’ strength is to supply the purest available high quality chitosan in the market: ChitoClear® • • • • Pure source High technical production Low heavy metal content Low bio-burden content 38 What is chitosan? • Deacetylated form of chitin, a natural fiber • Most abundant naturally occurring amino-polysaccharide • Unique physiochemical characteristics and biological activities • Origin and process influence chemical and physical properties • Chitin is insoluble in aqueous media • Chitosan soluble in acidic conditions → Due to protonation (NH3+) • Hydroxyl groups for interactions BIOACTIVE COMPOUND 39 What is so special about chitosan? • Important biological properties Biocompatible, biodegradable, non-toxic Analgesic, antitumor, hemostatic Mucoadhesive, film-forming, permeation enhancing Fat-binding, anticholesterolemic Antimicrobial, antioxidant 40 What can chitosan do for you? • Dietary supplement and functional ingredient Weight management Biopreservative, emulsifier, processing aid • Biomedicine Hemostatic and wound healing Tissue-engineering scaffolds Drug delivery • Personal care and cosmetics • Several other applications: 41biocatalysis Textile, wastewater treatment, metal reduction, Chitosan in Weight Management • Obesity problem worldwide; humans and pets • Several health problems related to obesity • Chitosan can bind lipids in the stomach – Decreasing fat digestion – Reducing caloric uptake – Contributing to weight and cholesterol control 42 Primex solution: rapid solubilisation in stomach acid LipoSan Ultra® is a patented chitosan product including succinic acid, a GRAS food additive. • • • • Safe and effective weight loss supplement More granular in texture / better flow properties Higher tap density than regular chitosan Superior fat binding capacity 43 The Natural Way of Weight Control Chitosan must be completely dissolved in stomach acid in order to effectively bind and block fat. LipoSan Ultra® is • Fast acting – dissolves in 3-5 min • More effective fat binding than generic chitosan products • Cholesterol (LDL) lowering agent • Clinically proven weight loss 44 Alternative Uses of LipoSan Ultra® • Dietary supplement: capsules, tablets – For humans at mealtime: Clinical study with 59 overweight women Non-restrictive diet for 8 weeks +/- LipoSan Ultra® Significant weight loss (1 kg) compared to 1.5 kg weight gain in placebo group – For pets before or at a meal: Added as a top dressing on dry food or mixed with food LipoSan Ultra® chewable tablets as a treat before eating 45 Alternative Uses of LipoSan Ultra® • Encapsulated LipoSan Ultra® – The only chitosan weight management product suitable for beverages and other ready-to-use foods – Encapsulation remains in weak acid food, but breaks down in the stomach – for active fat absorption – New market opportunities for convenient functional foods Vitafoods Europe 2013 – Best New Product: Selected as one of the finalists for the Nutraceuticals Business & Technology Awards 46 Important markets for high quality ChitoClear: Biomedical – Wound healing – Cosmetics – Personal care • Need for natural solutions – To combat pathogens resistant to conventional drugs – As biocompatible and biodegradable polymers – To replace synthetic compounds • Studies have shown that ChitoClear® chitosan – – – – Is not a skin sensitizer; non-allergenic Reduces bleeding and wound infection Enhances healing Can treat wet eczema in animals 47 Wound healing gel & spray Case studies on animals By Ulrike Koch, DVM, Tierärztliche Klinik Oerzen ChitoClear gel used in various, predominantly old, non-healing, contaminated wounds, where other therapies had failed: Good healing properties and useful in contaminated as well as old and chronic wounds Reduced infection, with anti-itching and anti-inflammatory properties Prevented scarring 7-yrs boxer: 8-week ointment treatments 48 Healed 12 days after use of ChitoClear gel Primex commercialised product brands suitable for your applications: 49 Thank you [email protected] STUDIES MENTIONED: R.N. Schiller, E. Barrager, A.G. Schauss, E.J. Nichols (2001) A randomized,double-blind, placebo controlled study examining the effects of a rapidly soluble chitosan dietary supplement on weight loss and body composition in overweight and mildy obese individuals. J. Amer. Nutrac. Ass. 4(1): 42-49. C. Oddsdóttir (2009) Extensive Injury to the Hock of a Mare. Report submitted to Primex by Dr. Charlotta Oddsdóttir DVM, Iceland, 6 p. U. Koch (2010) Experience with ChitoClear chitosan as a wound healing gel. Report submitted to Primex by the Tierdrztliche Klinik Oerzen, Germany, September 2010, 32 p. G. Arcelin (1999) RCC Project 729854 – Primex Chitosan: Contact Hypersensitivity in Albino Guinea Pigs, Bühler Test. Report submitted to Primex Ingredients ASA by RCC Ltd, Switzerland, 19.09.99, 42 p. I.T. Harvima, M. Lyyra, E. Sarkkinen, N. Tapola, R.J. Harvima (2002) Evaluation of chitosan as possible compound causing immediate hypersensitivity reactions. Report submitted to Primex ehf by Oy Foodfiles Ltd., Finland, 15.03.02, 29 p. M. Burkatovskaya, G.P. Tegos, E. Swietlik, T.N. Demidova, A.P. Castano, M.R. Hamblin (2006) Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice. Biomaterials 27(22): 4157-4164. J.P. Malmquist, S.C. Clemens, H.J. Oien, S.L. Wilson (2008) Hemostasis of oral surgery wounds with the Hemcon Dental Dressing. J. Oral Maxillofacial Surg. 66(6): 1177-1183. 51
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