Microsoft PowerPoint - SILKSKIN PRESENTATION [Sola

SilkSkin
SERICIN COMPLEX GLOVES
What is SERICIN?
•
SERICIN is a protein created by Bombyx
mori (silkworms) in the production of silk
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Silk consists mainly of two proteins,
SERICIN and fibroin
•
Fibroin being the structural center of the
silk
•
SERICIN being the gum coating the fibres
and allowing them to stick to each other.
•
Silk SERICIN has been used for over
3500 years by the world elite to
rejuvenate their hair and skin
SERICIN Applications
•
Skin Creams (Anti-Aging)
•
Hair Care (Moisturizer)
•
Air Filters (Antimicrobial)
•
Textiles (Antimicrobial)
•
Edible Supplements
(Antioxidant)
•
Serum for tissue culture
•
Tissue Scaffold
Why SERICIN?
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SERICIN structure and the content of amino acids are
similar to the skin of human body, thus it is highly
compatible and absorbed easily with human skin (Padol
2012)
•
SERICIN benefits:
•
Moisturizing
•
Anti-Aging
•
Wound Healing
•
Anti-Microbial
SERICIN Content
•
SERICIN amino acid
composition that resemble
natural moisturizing factor
(NMF), which is naturally part
of our human make up.
SERICIN Moisturizing
•
•
•
Decrease skin impedance
•
Moisturizing of upper layer of skin
•
Increase in water holding
Increase hydroxyproline (protein binding capacity to stratum corneum)
•
by restoration of amino acid
•
hydroproxyline important in stabilizing triple helical structure of collagen and connective tissue
•
protein used to restore moisturization and skin tightening
Reduce excessive transepidermal water loss (TEWL)
•
•
Occlusive effect preventing water loss from stratum corneum and allow water to accumulate
horny layer
Replacement of natural moisturizing factor (NMF) due to occurs by aging
SERICIN Moisturizing
•
Skin treated with SERICIN
showed less flakes and
white ridges
•
Decrease in flakes and
ridges of the skin reveals
the moisturization of the skin
•
SERICIN forms a
moisturizing, semiocclusive, protective, anti
wrinkle film on the skin
surface imparting an
immediate, long lasting,
smooth, silky feeling.
Causes of Aging
•
Intrinsic factors
•
Biological aging
•
hormonal changes
•
metabolic processes
Causes of Aging
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Extrinsic factors (also accelerate intrinsic factor)
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UV radiation causing
•
Photo-aging
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Generate Reactive Oxygen Species (ROS)/ Oxidative Stress
leading to cell or tissue injury, they are responsible for many
diseases such as cancer
•
over-production of elastase degrading elastin fiber (losing
elasticity and wrinkle formation)
•
Sun exposure induces tyrosinase (Melanin
production/blackened peeled potato)
SERICIN Anti-Aging
•
•
Reactive Oxygen species (ROS) scavenging/Antioxidant
•
Due to high content of hydroxy amino acids (Serine & Threonine)
chelating trace elements such as copper and iron. Fan et al 2007
•
Evidenced by lipid peroxidation test by Kato et al 1997
Anti-tyrosinase (production of melanin e.g. blackening of sliced potato)
•
•
SERICIN contains flavonoids and carotenoids elements.
Chlapanidas et al 2013 confirmed SERICIN exhibits strong antityrosine properties.
Anti-elastase
•
Chlapanidas et al 2013 concluded anti-elastase properties in
SERICIN that prevents loss of skin elasticity and wrinkle formation
SERICIN Anti-Aging
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UV protection
•
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SERICIN has suppressive activity against both chemical and
UV radiation by inhibiting epidermal oxidative stress,
suppression of COX-2 expression, and moisturizing effect.
Zhaorigetu et al 2003
Anti-apoptosis (programmed cell death)
•
Western blotting test result indicates Sericin stimulated bcl-2
(an anti-apoptosis signal) by reducing the oxidative stress in
fibroblast. Kitisin et al 2013
•
Blocking the caspase activity by reducing oxidative stress in
HaCat. Dash et al 2008
SERICIN Anti-Aging
•
Zhaorigetu et al 2003
conduct acute 7 days
UVB radiation on mouse
skin
•
Vehicle (control), BSA
(control), SIREN
•
Rare 4-HNE (oxidative
stress marker) on
SERICIN treated skin
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Hardly observed COX-2
(marker of epidermal UVB
exposure) expression on
SERICIN treated Skin
SERICIN Anti-Aging
•
Dash et al 2008 concluded anti-apoptotic effect of
SERICIN in UVB-irradiated cells is through the
blocking of caspace activities, possibly by
reducing oxidative stress in HaCat (Human Skin)
SERICIN Anti-Aging
•
Dash et al 2007 test
SERICIN antioxidant against
H2O2.
•
H2O2 as a model oxidant
has been well studied.
•
Report conclude SERICIN is
an ideal molecule to prevent
oxidative stress.
SERICIN Wound Healing
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Methionine and cysteine promote cell growth and collagen synthesis.
•
Aramwit et al 2007 concluded that SERICIN has good hydrophilic
properties, compatibility, and biodegradation.
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SERICIN treated wound had much smaller inflammatory reactions and
wound-size reduction greater than control.
•
Mean time in days for 90% healing for SERICIN treated wound is much
lesser than control
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Histological examination shows SERICIN treated wound revealed
complete healing, no ulceration, no rash, and increase in collagen
compared to control, which showed some ulceration and inflammatory.
SERICIN Wound Healing
SERICIN Wound Healing
SERICIN Antimicrobial
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Senakoon et al 2009 &
Rajendrana et al 2012
concluded that SERICIN
antibacterial property
against E. Coli and S.
Aureus
•
E. Coli cell shrunk and
deep roughening of cell
surface
•
S. Aureus cell exhibits
segregation, deformation,
reduced size and
shrinkage
SERICIN
Antimicrobial
•
Jassim et al 2010 examined
SERICIN antibacterial
property by growing of
spores colonies and
examining tensile strength
of SERICIN treated and
untreated cotton fabric
•
The average of untreated
fabric is 14.25 NIT, whereas
treated fabric is 96 NIT
(6.5X)
The End