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Informations CSGIT
AGENDA! ! Wednesday!May!28th:! ! 16h00!'!19h30! ! ! 18h00!'!19h30!! ! ! 20h00!! ! ! ! 20h00!'!20h05! ! ! 20h05!–!20h15! ! ! 20h15!–!21h15! ! ! 21h15!'!! ! ! ! ! Registration! ! BBQ!!! Meeting!Opening! Welcome!Notes:!Jean'Yves!Masson! Introduction!of!Keynote!Speaker:!Dan!Durocher! Keynote!Address:!Roger!A!Greenberg!(University!of!Pennsylvania)! Interchromosomal!Homology!Searches!Drive!Directional!ALT!Telomere!Movement! and!Synapsis! ! Social! Thursday!May!29th:! ! 07h00!! ! ! ! 8h00!'!8h55!! ! ! ! ! ! ! 08h55!'!09h00! ! ! 09h00!–!09h25! ! 09h25!–!09h50! ! ! ! ! 09h50!–!10h15! ! 10h15!–!10h40! ! ! ! ! ! ! ! ! 10h40!–!11h05! ! ! ! ! ! ! ! ! Breakfast!(until!10!am)!! ! Registration! Get!to!the!break!(1)! Introduction!by!the!Chair:!Grant!Brown! Jacques!Côté!(Université!Laval)! Regulation!of!genome!stability!by!the!NuA4!acetyltransferase!complex:!! chromatin!and!beyond! Victoria!Fell!(Schild'Poulter!Lab;!University!of!Western!Ontario)! Ku70!S155!regulates!cell!cycle!checkpoints!and!DNA!damage!signaling! Nicole!L.!Batenburg!(Zhu!lab;!McMaster!University)! Role!of!Cockayne!Syndrome!Group!B!(CSB)!Protein!in!Regulating!ATM!Activation!and! DNA!Double!Strand!Break!Repair! Aaron!A.!Goodarzi!(University!of!Calgary)! Opposing!ISWI'!and!CHD'class!chromatin!remodeling!activities!orchestrate!Artemis'! dependent!heterochromatic!DNA!double!strand!break!repair! ! Coffee!Break! New!ways!to!look!at!cancer!cells! 2! 11h05!'!11h10! ! ! 11h10!–!11h35! ! ! ! ! !! ! ! 11h35!–!12h00! ! ! ! ! 12h00!–!12h25!!! ! ! 12h25!–!13h45! ! ! ! 13h50!–!15h00! ! ! 15h00!–!16h10! ! ! 16h10!–!16h25!!! ! ! ! ! ! 16h25!–!16h30! ! ! 16h30!–!16h55! ! ! ! ! ! ! ! 16h55!–!17h20! ! ! ! ! 17h20!–!17h45! ! ! ! ! 17h45!–!18h00! ! ! ! ! 18h00!–!18h15! ! ! ! ! ! ! 18h15!–!19h55! ! ! ! ! ! ! ! 19h55!–!20h00! ! ! 20h00!–!20h25! ! ! ! ! !! ! ! 20h25!–!20h40! ! ! Introduction!by!the!Chair:!Yannick!Doyon! Ester!Falconer!(Lansdorp!lab;!BC!Cancer!Agency)! High'resolution,!high'throughput!profiling!of!genomic!structural!heterogeneity!of!! single!cancer!cells!using!Strand'seq.! Sabine!Mai!(University!of!Manitoba)! Telomere!dysfunction!and!genomic!instability! Stephen!Meyn!(University!of!Toronto)! Quantitative!analysis!of!extrachromosomal!telomere'repeat!DNA!in!individual!! human!cells!by!Halo'FISH! ! Lunch! Poster!Session!A!(EVEN!numbers!are!presented)! Poster!Session!B!(ODD!numbers!are!presented)! ! Coffee!Break! Tales!of!chromosomes!and!telomeres! Introduction!by!the!Chair:!Momchil!Vodenicharov! Damien!D’Amours!(Université!de!Montréal)! The!polo'box!domain!of!Cdc5!promotes!adaptation!to!DNA!damage!by!targeting!polo!! kinase!activity!to!centrosomes! Tina!L.!Sing!(Brown!lab;!University!of!Toronto)! The!RSC!complex!functions!to!maintain!ploidy!in!Saccharomyces!cerevisiae! Emilio!Cusanelli!(Chartrand!lab;!Université!de!Montréal)! Loss!of!sister'chromatid!cohesion!at!short!telomeres.! Emmanuel!Bajon!(Wellinger!lab;!Université!de!Sherbrooke)! Yeast!telomerase!finally!ends!up!a!single! Pierre!Billon!(Côté!lab;!Université!Laval)! PCNA!acetylation!regulates!error'prone!TLS!activities! ! Supper! Consequences!of!impairing!DNA!repair! Introduction!by!the!Chair:!Kirk!McManus! Niraj!Joshi!(Masson!lab;!Université!Laval)! The!identification!of!Fancd2!DNA!binding!domains!reveals!hidden!nuclear!localization!! sequences! Frédérick!Bouffard!(F.!Durocher!lab;!Université!Laval)! 3! 20h40!–!21h05! ! 21h05!–!21h30!!! 21h30!–!21h45! ! ! ! ! ! 21h45!'!! ! ! ! Analysis!of!a!splicing!isoform!of!the!FancE!gene!and!its!impact!on!DNA!repair!! efficiency.!! Nicolas!Malaquin!(Rodier!lab;!Université!de!Montréal)! Chromatin!stress!trigger!cellular!senescence!and!rapid!inflammatory!secretion!! without!DNA!damage.!! Dindial!Ramotar!(Université!de!Montréal)! The!histone!H2B!R95A!mutant!is!defective!in!recruiting!the!FACT!complex!protein!! Spt16!and!causing!telomeric!dysfunction!that!alters!drug!responses! Hao!Ding!(University!of!Manitoba)! Mouse!modeling!of!RTEL1!function! ! Social! Friday!May!30th:! ! 07h00!! ! ! ! ! ! ! ! 08h55!–!09h00! ! ! 09h00!–!09h25! ! ! ! ! 09h25!–!09h50! ! 09h50!–!10h15! ! 10h15!–!10h40! ! ! ! ! ! 10h40!–!11h05! ! ! ! ! ! ! 11h05!–!11h10! ! ! 11h10!–!11h25! ! 11h25!–!11h40! ! 11h40!–!11h55! ! ! ! Breakfast!(until!10!am)! Get!to!the!break!(2)! Introduction!by!the!Chair:!Raymund!J.!Wellinger! Guy!Poirier!(Université!Laval)! Towards!systematic!identification!of!ADP'ribosylated!residues!in!mammalian!PARPs! Girish!M.!Shah!(Université!Laval)! Poly(ADP'ribose)!polymerase'1!and!PARylation:!New!players!in!mammalian!! nucleotide!excision!repair! Zubaidah!Ramdzan!(Nepveu!lab;!McGill!University)! RAS'Transformation!in!Cancer!Cells!Requires!CUX1'Dependent!Repair!of!! Oxidative!DNA!Damage! Javier!M.!Di!Noia!(IRCM!Montréal)! AID!coordinates!DNA!breaking!and!repair!during!antibody!class!switch!recombination.! ! Coffee!Break! Telomerase!function!in!health!and!disease! Introduction!by!the!Chair:!Francis!Rodier! Pedro!Castelo@Branco!(Tabori!lab;!University!of!Toronto)! THOR!methylation!provides!insight!into!the!telomere!maintenance!landscape!of!! malignant!gliomas.! Johanna!Mancini!(Autexier!lab;!McGill!University)! Selective!telomere!shortening!in!cancer!cells!by!a!! Pt!(II)!Phenanthroimidazole!G'quadruplex!ligand.! Tara!Beattie!(University!of!Calgary)! Influence!of!telomere!dynamics!on!disease!progression!and!response!to!! therapeutics!in!bone!marrow!failure!syndromes.! 4! 11h55!–!12h10! ! ! ! ! 12h10!–!12h25! ! ! ! ! ! ! 12h25!–!13h55! ! ! ! Judy%M.%Wong!(University!of!British!Columbia)! Non=canonical!telomerase!functions,!to!protect!against!genotoxic!events.! Nezaha%Ozlem%Arat!(Harrington!lab;!Université!de!Montréal)! The!importance!of!telomere!integrity!in!the!stability!of!stem!cell!differentiation! ! Lunch% What%happens%at%the%break%..! ! 13h55!–!14h00!!! ! 14h00!–!14h25! ! 14h25!–!14h40! ! ! ! ! 14h40!–!15h05! ! ! ! ! 15h05!–!15h30! ! ! ! ! 15h30!–!15h45! ! ! ! ! ! 15h45!–!16h10!!! ! 16h10!–!16h15! ! ! 16h15!–!17h15! ! % % % ! 18h30!–! ! ! ! Introduction!by!the!Chair:!Louis%Flamand! Amélie%Fradet@Turcotte!(D.!Durocher!lab;!University!of!Toronto)! RNF168!and!RNF169!directly!interact!with!histone!H2A!! ubiquitylated!on!lysine!13!and!15! Razq%Hakem!(University!of!Toronto)! RNF168!Substrates!and!Its!In!Vivo!Functions!! Michael%J.%Hendzel!(University!of!Alberta)! Ubiquitin=dependent!regulation!of!ATM!retention!in!double=strand!! break=associated!foci.! El%Bachir%Affar!(Université!de!Montréal)! Role!of!The!Tumor!Suppressor!and!Deubiquitinase!BAP1!in!DNA!Double=Strand!! Break!Repair.! Hemanta%Adhikary!(Masson!lab;!Université!Laval)! Formation!of!DNA!double=strand!breaks!by!the!meiotic!recombination!protein!Spo11.! ! Coffee!Break! Introduction!of!Keynote!Speaker:!Raymund!J.!Wellinger! Keynote%Presentation:%Peter%Baumann%(Stowers%Institute%for%Medical%Research)% Telomerase!Biogenesis!and!Telomere!Architecture! ! Banquet!–!Social!=!Prizes! Saturday%May%31st:%% ! 07h00!! ! ! 10h30!! ! ! ! ! Breakfast!(until!10!am)!and!lunchbox!pickup!!! ! ! Coach!to!the!airport % % % 5! Canadian&Symposium&on&Telomeres&and&Genome&Integrity& ! Official'documents:!Visitors!to!Canada!must!hold!a!valid!passport!and,!in!some!cases,!a!visa.! For!more!information,!please!visit!the!Citizenship!and!Immigration!Canada!web!site:! http://www.cic.gc.ca/english/visit/index.asp! ' Getting'to'Québec'City':' By' air:' Visitors! can! fly! to! Québec! City,! located! in! the! northeastern! region! of! North! America.!Québec!City,!in!fact,!is!a!mere!90!minutes!flight!from!Toronto.!Efficient!rail!and!road! networks! link! Québec! City! to! bordering! provinces! and! states.! For! international! travelers,! Québec! CityJJean! Lesage! Airport! is! the! most! convenient! way! to! reach! the! city.! In! order! to! find!a!taxi,!a!limousine!or!other!means!of!transportation,!please!go!to!the!information!desk! inside!the!terminal!before!the!security!checkpoint.!Travelling!in!Taxi!to!Manoir!du!Lac!Delage! is!about!60$.!! ! Free! shuttle! from! the! airport! to! Manoir! du! Lac! Delage:! A! shuttle! bus! will! leave! from! the! airport! on! May! 28th! at! 13h15! and! 16h15! to! Manoir! du! Lac! Delage.! ! Please! follow! the! indications! for! Canadian& Symposium& on& Telomeres& and& Genome& Integrity& just! outside! the! arrivals.!The!airport!is!fairly!small,!it!will!be!easy!to!find.!! & ! By' train:' VIA! Rail! Canada! trains! run! daily! from! Toronto,! Ottawa! and! Montréal! to! Québec!City.!There!are!two!train!stations!in!Québec!City:!Gare!du!Palais!(Central!Station)!and! Gare!de!SainteJFoy.!From!there,!you!will!need!to!take!a!Taxi!to!Manoir!du!Lac!Delage.!' ! Meeting' location:! Manoir! du! Lac! Delage.! (http://www.lacdelage.com/en/?lang=en).! Please! see!directions!from!the!airport!to!Manoir!du!lac!Delage!in!the!following!pages.!! ! ! ! ! De $’a'r)p)rt ,ea-./esage (YQB) 7 fr)9 ,ea-./esage airp)rt Tourner à droite sur Route de l’Aéroport. Tur$ right *$t* R*ute de .’A1r*p*rt3 Tourner à gauche sur boul. Wilfrid-Hamel. Tur$ .eft *$t* B*u.3 Wi.frid7Ha:e.3 À gauche, rejoindre Autoroute 40 E/Autoroute 73 N en direction de Saguenay/SainteAnne-de-Beaupré. Tur$ .eft t* :erge *$t* Aut*r*ute 40 E>Aut*r*ute 73 A t*wardSague$ay>Sai$te7A$$e7de7Beaupr13 Suivre Autoroute 40 E/Autoroute 73 N. Eerge *$t* Aut*r*ute 40 E>Aut*r*ute 73 A3 40, avenue du Lac, Lac-Delage, G3C 5C4 Tél. : 418-848-2551 / Sans frais 1-888-202-3242 Prendre la sortie 142E pour Autoroute 40E/Autoroute 73N en direction de Saguenay/Sainte-Anne-de-Beaupré. Ta#e exit 142E t- stay -0 Aut-r-ute 40 E5Aut-r-ute 73 8 t-wardSague0ay5Sai0te A00e de Beaupre? Prendre la sortie 167, direction Stoneham/Tewkesbury/Lac-Delage. exit 167 f-r QuCbec 371 t-ward St-0ehaG5Tew#esbury5HacIDeKage? Ta#e Tournez à gauche sur 1re Avenue (panneaux pour Québec 371 S). Tur0 Keft -0t- 1e Ave0ue (sig0s f-r QuCbec 371 S)? Continuez sur Avenue Tewkesbury/QC-371 S (panneaux pour Lac-Delage /Stoneham /Tewkesbury). C-0ti0ue -0t- Av Tew#esbury5QCI371 S (sig0s f-r Hac DeKage5St-0ehaG)? Tournez à gauche sur Chemin de la Grande Ligne. Tur0 Keft -0t- CheGi0 de Ka Gra0de Hig0e? Tournez à droite sur Avenue du Lac? Tur0 right -0t- Av du Hac? Tournez à gauche sur Rue du Pied des Pentes. Tur0 Keft -0t- Rue du Pied des Pe0tes? Le stationnement se trouve à votre gauche. The par#i0g is -0 y-ur Keft? 40, avenue du Lac, Lac-Delage, G3C 5C4 Tél. : 418-848-2551 / Sans frais 1-888-202-3242
