Prof Sebastian Lucas
Transcription
Prof Sebastian Lucas
Case 11 • Male Turk, aged 29yr • No past medical history • Involved in a fracas at Heathrow Airport, and punched in the stomach • Collapsed shortly after, in shock • Admitted to a liver unit, and scanned – image attached Case 11 • Clinical diagnosis: ?liver cancer, ?what • Taken to operating theatre and liver area explored; bleeding and a cystic mass. • Radiological angio-obliteration attempted, and failed • Needle core biopsy of liver lesion – this slide • Follow-up: after supportive care and appropriate chemotherapy, recovered and discharged Diagnosis • Typical scolices of Echinococcus granulosus • In the hepatic venules • From a classical hydatid cyst in the liver – Post-trauma • Clinically anaphylactic shock from release of antigen-rich cyst fluid Collateral damage – ischaemic degeneration Case 11 • Submitting pathologist’s diagnosis: – Schistosomiasis • Other small egg-like parasites in liver: – Ascaris lumbricoides egg granuloma – Clonorchis & Opisthorcis egg granuloma – Enterobius vermicularis worm/egg granuloma Schisto in liver Liver Enterobius – eosinophilic necrotic granuloma Echinococcus life cycle Hydatid cysts E.granulosus E.multilocularis (alveolar) Contrasting imaging E.granulosus E.multilocularis Contrasting pathologies E.granulosus Emultilocularis How do pathologists diagnose hydatid cysts? • • • • • FNA BAL Surgical biopsy Surgical resection At autopsy Dead cysts – no scolices, only laminated membrane Case 10 Brain biopsy Case 10 • Female 40yr Ghanaian • Presented with headache and visual disturbance • Neuroimaging showed a cystic lesion in the suprasellar space Case 10 • Clinico-imaging diagnosis = ?craniopharyngioma • Biopsy of the lesion (unclear whether completely removed or not) – this H&E slide • Thanks to Dr Leslie Bridges, St George’s Hospital neuropathology. Differential diagnosis • Taenia solium – Cellulose cysticercosis • Obviously a larval cestode • Racemose cysticercus • Proliferating larval cestode NOS • Taenia crassiceps – Rodent host usually • Taenia multiceps – (coenurus cyst) • But which one? • …or none of these? Cellulose cysticercus And another one.. Coenurus T.multiceps – multiple scolices in one cyst Taenia crassiceps in a patient with Hodgkin lymphoma Taenia crassiceps Heldwein et al Am J Trop Med Hyg 2006, 75:108-111 Lucas S et al Abnormal development of Hymenolepis nana larvae in immunosuppressed mice J Helminthology 1980 & Lancet letter 1979 Differential diagnosis • Taenia solium – Cellulose cysticercosis • Racemose cysticercus • Typical location • No scolices within • • • But which one? Proliferating larval cestode NOS Taenia crassiceps – Rodent host usually • • Obviously a larval cestode Taenia multiceps – (coenurus cyst) • …or none of these? Question of the hour • Are racemose and cellulose cysticerci: – The same species (T.solium) under different host circumstances? • Location • Immune response – Different species? • “Genetic similarity between cysticerci of T.solium isolated from human brain and from pigs” • Hinojosa-Juarez et al; Infect Genet Evol 2008, 8:653-656 • Human or pig [Mexico] • Cellulose or racemose • = genetically identical metacestodes of T.solium. Life cycle of Taenia solium CDC apeing ET? Case 10: Follow up • Cyst probably removed in toto • Rx: praziquantel • Hydrocephalus persisted • V-P shunt inserted • Intra-abdominal problems ?abscess