Évaluation de la conscience aux soins intensifs
Transcription
Évaluation de la conscience aux soins intensifs
Évaluation de la conscience aux soins intensifs Steven Laureys Coma Science Group Service de Neurologie & Centre de Recherches du Cyclotron Université de Liège www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Overview Disorders of consciousness Behavioural evaluation Electrophysiology Neuroimaging Ethics & quality of life Terry Schiavo °1963, vegetative 1990, † 2005 www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion A brief history of coma www.comascience.org Bjørn Ibsen (1952) Rigshospitalet Copenhagen The resuscitation greats. Bjørn Ibsen Resuscitation. 2003 www.comascience.org Pius XII (1957) www.comascience.org Coma dépassé (1959) www.comascience.org Jean Morelle & Guy Alexandre The first organ transplant from a brain-dead donor Neurology, 2005;64;1938-1942 (1963) www.comascience.org Christiaan Barnard Louis Washkansky (1967) www.comascience.org Ad Hoc Committee Harvard (1968) www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Disorders of consciousness www.comascience.org QUESTIONS (répondez par OUI ou NON) Age / Sexe (F-M) / Nationalité / Profession 1. L’esprit et le cerveau sont deux entités séparées 2. L’esprit est une entité purement physique 3. Une part spirituelle de nous-même survit après la mort 4. Chacun de nous a une âme qui est séparée de notre corps www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Mind brain beliefs Zeman 2005 in The Boundaries of Consciousness (Ed) Laureys www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Consciousness: arousal & awareness Laureys, Owen and Schiff, Lancet Neurology, 2005 AWARENESS LOCKED-IN SYNDROME AROUSAL MINIMALLY CONSCIOUS STATE AWARENESS AWARENESS AROUSAL AWARENESS VEGETATIVE STATE AROUSAL COMA AROUSAL AWARENESS AROUSAL NORMAL CONSCIOUSNESS www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Clinical evaluation The absence of proof isn’t proof of the absence Anonymous www.comascience.org Brain death criteria Wijdicks, NEJM 2001 www.comascience.org Motor activity in brain death Lazarus' sign in brain death Bueri et al Mov Disord. 2000, 15:583-6 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives MOTOR RESPONSIVENESS Reflex versus voluntary professional reinsertion live independently severe disability MCS moderate disability good recovery communication voluntary behavior VS eye opening coma COGNITIVE CAPACITY Laureys et al., Current Opinion in Neurology, 2005 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Glasgow Coma Scale Teasdale & Jennett, Lancet, 1974 E - eye opening C. Not assessable AROUSAL 4. Spontaneous y 3. To speech HELLO PAIN 2. To pain & PAIN 1. None & Laureys et al., Yearbook of Intensive Care Medicine, 2002 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Glasgow Coma Scale Teasdale & Jennett, Lancet, 1974 V - verbal response T. Not assessable 5. Oriented conversation A.C. Cident ICU Liège, March 2002 AWARENESS WHERE AM I ? 4. Confused speech STUPID !!! 3. Inappropriate words 2. Incomprehensible sounds 1. None Laureys et al., Yearbook of Intensive Care Medicine, 2002 10… OFF !? GROAN … www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Glasgow Coma Scale Teasdale & Jennett, Lancet, 1974 M - motor response y AWARENESS CLOSE YOUR EYES 6. Obeys simple commands PAIN 5. Localizes pain 1 4. Withdraws (normal flexion) PAIN 3. Stereotyped flexion PAIN 2. Stereotyped extension PAIN 1. None PAIN Laureys et al., Yearbook of Intensive Care Medicine, 2002 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives FOUR Wijdicks et al, 2005 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives FOUR Wijdicks et al, 2005 www.comascience.org Blink and you live Laureys et al., Progress in Brain Research, 2005 www.comascience.org www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Pensez-vous que 5. Le patient en état végétatif ressent la douleur? 6. Le patient en état de conscience minimale ressent la douleur? 7. Le patient en locked-in syndrome ressent la douleur? Être en état végétatif chronique est pire que la mort 8A. du point de vue du patient? 8B. du point de vue de la famille? Être en état de conscience minimale chronique est pire qu’être en état végétatif 9A. du point de vue du patient? 9B. du point de vue de la famille? Être en locked-in syndrome est pire qu’être en état végétatif ou en état de conscience minimale 10A. du point de vue du patient? 10B. du point de vue de la famille? www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Coma recovery scale www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Fear for misdiagnosis www.comascience.org Andreas Vesalius (1514-1564) www.comascience.org Fear of being buried alive 1896, Karnice-Karnicki, chamberlain of the tsar of Russia (1896) www.comascience.org Death and the media (1980) Transplants - Are the donors really dead ? www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Misdiagnosis of brain death Over last 50 years no single recovery recorded if properly declared brain death (apnea test!) www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Misdiagnosis of vegetative state n=103 post-comatose patients 45 clinical consensus diagnosis of “vegetative state” 27 Coma Recovery Scale diagnosis (Coma Recuperatie Schaal) ª 40% misdiagnosis 38% Schnakers et al Ann Neurol ´06 Schnakers et al, submitted 37% Childs et al Neurology ´93 43% Andrews et al BMJ ´96 www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion How to assess eye tracking ? n=52 Vanhaudenhuyse et al, JNNP 2008 www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Blinking to threat n=91 VS patients 46 (51%) blinking to visual threat 17 (37%) recovered to MCS 11/45 without blink recovered MCS (24%) ª blinking is no sign of consciousness Schnakers, Giacino et al, submitted www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Electrophysiology www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives time-frequency balanced spectral entropy EEG entropy Gosseries et al, in preparation 75% sensitivity 75% specificity CONTROL (n=15) MCS (n=15) VS (n=15) www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Cognitive evoked potentials minimally conscious state µV -10.0 OTHER NAMES -7.5 -5.0 OWN NAME N1 -2.5 0.0 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 ms 2.5 5.0 7.5 10.0 Laureys, Perrin et al., Neurology, 2004 Perrin et al, Archives in Neurology, 2006 P3 www.comascience.org disorders of consciousness | clinical evaluation | neuroimaging | ethics & quality of life | future | conclusion Functional neuroimaging The map is not the territory Alfred Korzybski (1879-1950) www.comascience.org disorders of consciousness | clinical evaluation | neuroimaging | ethics & quality of life | future | conclusion c resting metabolism d activation studies z passive z active www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Resting metabolism Laureys, Owen & Schiff, Lancet Neurology, 2004 (sleep data from Pierre Maquet; anesthesia data from Mike Alkire) www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives “Awareness network” n=60 Laureys et al, NeuroImage 1999 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives “miracle” recovery from MCS Terry Wallis wakes from 19-year MCS Voss, … Schiff, Journal of Clinical Investigation, 2006 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Thalamo-cortical modulation Laureys et al., Lancet, 2000 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Thalamic stimulation Schiff et al., Nature, 2007 www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Amantadine in MCS amantadine Schnakers et al, JNNP 2008 amantadine www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Neuroimaging c resting brain function d brain activation studies passive paradigms z active paradigms z www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Pensez-vous que 11. on peut arrêter le traitement (nutrition et hydratation) chez le patient en état végétatif chronique ? 12. on peut arrêter le traitement chez le patient en état de conscience minimale chronique ? 13. on peut arrêter le traitement chez le patients locked-in chronique? Souhaiteriez-vous de continuer à vivre si vous étiez : 14. en état végétatif chronique 15. en état de conscience minimale chronique 16. en locked-in syndrome chronique www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Do they feel pain ? NO RESPONSE AWAKENING GRIMACING www.comascience.org disorders of consciousness | clinical evaluation | neuroimaging | ethics| & qualityethics of life& |quality future conclusion disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging methods, of |life | perspectives Vegetative is not apallic Painful stimulation Low level disconnected cortical activation Laureys et al., Neuroimage, 2002 Laureys, Nature Reviews Neuroscience, 2006 www.comascience.org Hable con Ella "…a (wo)men’s brain is a mystery... and even more so in this state." Pedro Almodóvar www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Emotional processing Laureys et al., Neurology, 2004 www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Neuroimaging c resting brain function d brain activation studies passive paradigms z active paradigms z www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Active fMRI paradigms Boly et al, NeuroImage 2007 Owen, Coleman, Boly, Davis, Laureys and Pickard, Science, 2006 www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion fMRI precedes the clinic vegetative Di et al, Neurology, 2007 minimally conscious www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Ethics & quality of life www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Locked-in syndrome (LIS) Laureys et al., Progress in Brain Research, 2005 www.comascience.org disorders of consciousness | clinicalevaluation evaluation | electrophysiology | neuroimaging | ethics & quality of of lifelife | conclusion disorders of consciousness | behavioural | electrophysiology | neuroimaging | methods, ethics & quality | perspectives Quality of life in LIS QUESTION 17. Anamnestic Comparative Self Assessment (Bernheim et al) XX X Locked-in patients n=70 X Matched healthy controls n=70 QUESTION 18. Êtes-vous croyant : Non-Oui (quelle religion / pratiquant ?) Bruno, Pellas… Laureys, in preparation www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Conclusions www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion Conclusions • Diagnosis • misdiagnosis of VS (40%) • behavioral evaluation (CRS-R) • need for objective markers of consciousness • Vegetative state • disconnection syndrome with impaired fronto-parietal neuronal “workspace” • Minimally conscious state • preserved emotional & pain perception • Locked-in syndrome • right to communicate, right to die, right to live www.comascience.org disorders of consciousness | clinical evaluation | electrophysiology | neuroimaging | ethics & quality of life | conclusion www.comascience.org thanks to also thanks to Melanie Boly MD Didier Ledoux MD Caroline Schnakers Audrey Vanhaudenhuyse Marie-Aurélie Bruno Olivia Gosseries Victor Cologan Pierre Boveroux MD Athena Demertzi Gustave Moonen MD PhD Christophe Phillips PhD Ing Quentin Noirhomme PhD Ing Pierre Maquet MD PhD the patients & families Frédéric Pellas MD (Nîmes) Adrian Owen PhD (Cambridge) Louis Puybasset MD (Paris) Fabien Perrin PhD (Lyon) Haibo Di PhD (Zhejiang) Joe Giacino PhD, Nico Schiff MD (NY) www.comascience.org