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Acne treatments only work if they get used.
All you need to do is find a teenager who’s
interested. Easier said than done. Not if you
prescribe Zindaclin.
This gel has been judged the most acceptable
prescribed topical antibiotic treatment for
mild to moderate acne.1 It only has to be applied
once a day; doesn’t need to be mixed with any
other ingredient; and can be kept in their rooms,
instead of the fridge.2 Which means teenagers
can be bothered to use it. Zindaclin even has
a 2-year shelf life, but we don’t think you’ll
be needing that.2
Zindaclin – First-line treatment for mild to
moderate acne.
O N C E A DAY
G E T S U S E D, G E T S R E S U LT S .
ZINDACLIN 1% Gel Abbreviated Prescribing Information. Presentation: Zindaclin 1% Gel contains clindamycin phosphate 1.2 %w/w equivalent to clindamycin
1% w/w. Indication: The treatment of mild to moderate acne vulgaris. Posology: Apply a thin film once daily to the affected area; Patient response should
be reviewed after 6 to 8 weeks of treatment and the duration of treatment should be limited to 12 weeks. Not for use in children under 12 years of age.
Contraindications: Hypersensitivity to clindamycin or any of the gel ingredients. Patients sensitive to lincomycin. Warnings and Precautions: If diarrhoea occurs with use, discontinue
immediately (risk of pseudomembranous colitis). If diarrhoea does not resolve on discontinuation of clindamycin, further investigation is recommended. Prolonged use of clindamycin
and other antibiotics may cause resistance. Avoid contact with the eyes and mucous membranes; bathe with copious amounts of water should contact occur. Pregnancy and Lactation:
Caution when administering to pregnant women. Avoid use whilst breastfeeding. Undesirable effects: Adverse effects occur in up to 10% of patients; these include dry skin, erythema and
burning, irritation around eyes, acne exacerbation, pruritus, scaly rash, and painful skin. Pack size: 30g tube. Price NHS £8.66. Legal category: POM Marketing Authorisation Number and
Holder: PL 20074/0002: Crawford Healthcare Ltd, Unit 1, Adams Court, Adams Hill, Knutsford, Cheshire, WA16 6BA, UK. Date of Preparation: April 2011.
Adverse events should be reported. Reporting forms and information can be found at www.yellowcard.gov.uk. Adverse events should also be reported to Medical Information
at Crawford Healthcare Ltd on 0870 192 3283.
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Zindaclin gets used, gets results
A randomised, single-centre crossover study was conducted
to determine and compare patient preferences. Over 4 weeks,
patients used each of 3 topical antibiotics for 1 week.1
The study showed that patients clearly preferred a gel
formulation that could be applied with the fingers,
once a day, and stored at room temperature for as
Attributes1
Zindaclin
Zineryt4
Dalacin T5
Clindamycin
+ zinc
Erythromycin
+ zinc
Clindamycin
Formulation
Gel
Solution
Lotion
Mixing
required
No
Yes
No
Application
method
Finger
Pad
Rollerball
Application
frequency
Once-a-day
Twice-a-day
Twice-a-day
Shelf life,
once opened
Up to 2 years
8 weeks
Up to 2 years
Cost per day6
£0.29
£0.52
£0.38
Product
Active
long as 18 months.
1
Zindaclin was the top ranked product in the post-treatment,
conjoint analysis. It had one of the most favourable safety
profiles, was liked best by the highest proportion of patients,
and received the highest overall satisfaction score on the
patient acceptability questionnaire.1
Zindaclin, once daily, may offer a means of improving
compliance and thus improving treatment success.3
Clindamycin plus zinc helps reduce
bacteria and inflammation
• Zindaclin features patented Residerm drug delivery
technology, which complexes clindamycin with zinc
Mean maximum plasma concentrations of clindamycin7
ions.7
p=0.668 n=24
1.2
• Residerm keeps the antibiotic where it’s needed –
1.0
the systemic circulation.7
• Mean plasma Cmax of clindamycin was approximately
30% and 50% lower with Zindaclin at days 1 and 5.7
• Zinc reduces bacterial resistance and improves skin
Concentration (ng/ml)
in the skin – and reduces transdermal absorption into
0.8
0.6
0.4
healing.8
• It regulates oil production in sebaceous glands and
0.2
prevents clogging.8
0
• Zinc also reduces inflammation and the appearance
of acne.8
Zindaclin
Day 1
Day 5
Clindamycin lotion
Adapted from Chassard, 2006
References: 1. Kellet N, West F, Finlay AY. Br J Dermatol 2006 Mar; 154(3):524-532. 2. Crawford Healthcare Zindaclin SmPC. April 2011. 3. Cunliffe WJ, Fernandez C, Bojar R et al. (the
original study was conducted with 4 products but Benzamycin has since been discontinued) J Dermatolog Treat 2005; 16:213-218. 4. Astella Pharma Ltd Zineryt SmPC. June 2011.
5. Pharmacia Dalacin T Topical Solution SmPC. May 2012. 6. May 2012 Drug Tariff. 7. Chassard D, Kanis R, Namour F et al. J Dermatolog Treat 2006 ;17(3) :154 -7. 8. Scientific data
available on request.
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