FrequentlyAsked Questions about DIM-PRO PLUS

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Frequently Asked Questions about
DIM-PRO PLUS
What is Diindolylmethane?
Diindolylmethane , or DIM, is a phytonutrient, found in broccoli and other cruciferous
vegetables such as Brussel’s sprouts, cabbage and cauliflower.
What does DIM do in the body?
DIM influences the metabolism of estrogens in the body. This is an important health
issue because estrogen has many effects on cell growth, health and function of
estrogen responsive tissues (breast, uterus, ovaries, cervix, prostate, testes, and bone).
There are three forms of naturally occurring estrogen compounds made in the body – estradiol, estrone, and estriol.
There are also xenoestrogens; synthetic estrogen-like compounds that enter the body through the ingestion and/or
inhalation of pesticides, drugs (hormone replacement therapy), fuels, and plastics. Combined, these estrogens
represent the body’s systemic estrogen pool.
Estrogen, whether synthetically derived or naturally formed, is broken down through detoxification pathways in the
liver and eliminated from the body. This is a crucial step in estrogen metabolism as excessive exposure to circulating
estrogens in the blood can trigger aberrant cell growth and function.
There are two different detoxification pathways in the liver by which estrogen can be metabolized. One pathway
yields estrogen derivatives known as 2-hydroxyestrone. The other pathway yields a 16-hydroxyestrone derivative.
The 16-hydroxyestrones have been associated with breast and uterine cancers, cervical dysplasia, uterine fibroids,
PMS, endometriosis, and obesity. These conditions are often the result of estrogen over-stimulation or dominance in
the body.
DIM works by positively influencing the production of 2-hydroxyestrone metabolites. As DIM increases these
“good” estrogen metabolites, there is a simultaneous reduction in the levels of the 16-hydroxyestrone form. This
shift in estrogen metabolism, evidenced by an increase in the 2:16 hydroxyestrone ratio, reduces the undue influence
of the 16-hydroxyestrone metabolites on cell growth and function.
What is BioResponse-DIM?
BioResponse-DIM is a patented “Phytosorb” delivery system that is the only clinically proven method known to
provide predictable absorption of DIM. In a recent human study as much as five times more diindolylmethane was
absorbed from BioResponse-DIM, than from crystalline diindolylmethane.
Could I obtain the same healthful benefits from DIM by simply eating more broccoli?
Consuming a diet rich in cruciferous vegetables is beneficial form many reasons. These vegetables are rich in
vitamins, minerals and fiber which promotes a healthy bowel. However, active therapeutic levels of DIM found in
2 capsules of BioResponse-DIM is equivalent to consuming over two pounds of raw broccoli. Consuming this
amount of broccoli a day may be problematic for some.
Why is glycine added to DIM-PRO PLUS?
Glycine is an amino acid that is utilized in Phase II detoxification pathways in the liver. Through glycination,
glycine forms a conjugate with a metabolic byproduct or drug rendering the newly formed compound water soluble
and ready for elimination from the body through the urine and feces. Glycine is also a precursor amino acid that
combines with glutamic acid and cysteine to form glutathione. Glutathione conjugation is a major Phase II
detoxification pathway that aids in the removal of toxic intermediates.
®
11312 200th St. East Graham, WA 98338 Phone: 800-753-4145 Fax: 866-817-9931 www.medifood.info
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DIM-PRO PLUS
Dim-Pro Plus nutritionally supports the activity of enzymes that
metabolize estrogen and aspirin. Current research demonstrates that
BioResponse diindolylmethane increases levels of good estrogens
(2-hydroxyestrogens/2-OHE1) which tend to inhibit abnormal cell
replication
while
reducing
levels
of “bad”
estrogens
(16-a-hydroxyestrone/16-a-OHE1 and 4-OH estrone).*
Supplement Facts
Serving Size: 1 Capsule
Amount Per Capsule:
BioResponse DIM® - 75 mg
(A patented, enhanced bioavailability complex containing min. 25%
diindolylmethane) Starch, diindolylmethane, vitamin E (d-alpha
tocopheryl succinate, [tocophersolan]), soy phosphatidylcholine, silica
% Daily Value
**
Glycine - 425 mg
**
** Daily Value not established for this ingredient.
What is Dim?
Dim or 3,3’-diindolylmethane is a natural product produced during the
autolytic breakdown of glucobrassicin, one of over 100 sulfur containing
glucose conjugates, known as glucosinolates that occur exclusively in
cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, kale
and mustard greens.
The immediate precursor of DIM in the plant is I3C or indole-3-carbinol,
which is liberated from glucobrassicin by the action of myrosinase, an
enzyme found in the cell wall of cruciferous vegetables, following
disruption of the sub-cellular compartmentalization of enzyme and
substrate via mastication.
Indole-3-carbinol undergoes extensive and rapid self-condensation
reactions under the acidic conditions of the stomach to form several
derivatives with distinctive biological activities.*
DIM is a major condensation product of I3C in vitro. DIM is also produced
in vivo since it has been readily detected in the livers and feces of rodents
administered I3C whereas I3C was not detected.*
Biological Actions of DIM on Estrogen Metabolism
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Toll Free: 1 (800) 753-4145
1. DIM alters estrogen metabolism in humans by up-regulating a
specific cytochrome P450 enzyme (CYP1A1), which speeds up the
conversion of estrone to 2-OH estrone (a "good" estrogen) at the
expense of the conversion to 4-OH estrone (a "bad" estrogen) and
16-alpha OH estrone, also a cancer causing estrogen metabolite. Breast
and prostate cancer risk increases if the ratio between 2-OH and
16-alpha OH estrone is skewed in favor of 16-alpha OH estrone
production by the respective cytochrome P450 enzymes.*
Phone: (253) 875-0413
Fax: 1 (888) 878-6193
www.medifood.info
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DIM-PRO PLUS
2. Up-regulating CYP1A1 using DIM is especially desirable if the woman has a single nucleotide polymorphism on
CYP1B1, which preferentially converts estrone into 4-OH estrone, another estrogen metabolite which increases a
woman's risk for breast cancer by creating DNA adducts.*
In summary, DIM enhances the production of 2-OH estrone. As DIM increases these "good" estrogen metabolites,
there is a simultaneous reduction in the levels of 4-OH estrone especially if a woman has a SNP on CYP1B1 (roughly
1 in 3 women do) and 16-alpha-OH estrone. This shift in estrogen metabolism, evidenced by an increase in the 2-OH
:16 alpha OH estrone ratio and reduction in 4-OH estrone levels, reduces the risk of unregulated cell proliferation and
growth and DNA adducts, respectively.*
Difference between DIM and BioResponse-DIM (DIM-Pro Plus by Functional Integrative
Therapies)
Crystalline diindolymethane is hydrophobic. It does not go into solution easily and therefore is poorly absorbed by
the human body. BioResponse-DIM, on the other hand, is a patented delivery system wherein DIM is wrapped in
phosphatidyl choline (lecithin) boosting absorption as much as five times compared to crystalline DIM. DIM-Pro
Plus by Functional Integrative Therapies contains not only BioResponse-DIM (75 mg per capsule) but also the amino
acid glycine. Glycine is utilized in a Phase II detoxification process called glycination, where it forms a conjugate with
various naturally occurring metabolic byproducts or pharmaceutical drugs to form water soluble compounds ready
for elimination from the body through the urine and feces. In addition, glycine combines with glutamic acid and
cysteine to form glutathione, an important tri-peptide in the removal of toxic heavy metals like mercury, lead and
cadmium, pesticides, herbicides and insecticides via glutathione conjugation, another Phase II detoxification
pathway.*
Who can benefit from BioResponse DIM?
Women who are taking hormone-replacement therapy.*
Women who are taking bio-identical hormones.*
Women diagnosed with ER+ breast cancer and worried about recurrence.*
Women considering or who have had IVF therapy.*
Women who are taking birth control pills.*
Premenopausal women who have severe menstrual signs and symptoms.*
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Toll Free: 1 (800) 753-4145
Phone: (253) 875-0413
Fax: 1 (888) 878-6193
www.medifood.info
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DIM-PRO PLUS
Case Study 1: Effect of Dim-Pro Plus on 2-OH estrone (2-OHE1) and 16-alpha OH estrone (16-alpha OH E1) and the
2-OH:16-alpha OH E1 ratio in a premenopause woman.
Age: 47
History: breast cancer in maternal grandmother
Genomic Test Result: SNP on CYP1B1
Present status: no breast cancer, not on HRT or bio-identical hormones and in good health
Exercise Regimen: lap swimming for 1 hour, 2 to 3 times per week
BMI: 18
Dim-Pro Plus
Supplementation
None
Dim-Pro Plus (1 cap/day)
Ref range
Urinary Estrogen Metabolites (pg/ml)
2-OHE1
16-alpha-OHE1
210
435
210
274
2-OH:16-alpha OH E1 ratio
0.48
0.77
0.40 to 1.40
Case Study 2: Effect of Dim-Pro Plus on 2-OH estrone (2-OHE1) and 16-alpha OH estrone (16-alpha OHE1) and the
2-OH:16-alpha OH E1 ratio in a peri-menopausal woman taking topical bio-identical hormones (progesterone,
estradiol, estriol).
Age 52
History: breast cancer in father's brother, maternal grandmother and mother
Genomic Test Result: SNP on CYP1B1
Present status: no breast cancer, on bio-identical hormones (progesterone and estradiol)
Dim-Pro Plus
Supplementation
None
Dim-Pro Plus (1 cap/day)
Ref range
Toll Free: 1 (800) 753-4145
Urinary Estrogen Metabolites (pg/ml)
2-OHE1
16-alpha-OHE1
115
390
419
406
Phone: (253) 875-0413
2-OH:16-alpha OH E1 ratio
0.29
1.03
0.40 to 1.40
Fax: 1 (888) 878-6193
www.medifood.info
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DIM-PRO PLUS
Case Study 3: Effect of Dim-Pro Plus on 2-OH estrone (2-OHE1), and 16-alpha OH estrone (16-alpha-OHE1) and
2-OH:16-alpha OH E1 ratio in a postmenopausal woman taking topical bio-identical hormones (progesterone and
estradiol).
Age 54
History: no breast cancer in family tree
Present status: no breast cancer, on topical bio-identicals hormones (progesterone, estradiol and testosterone)
Dim-Pro Plus
Supplementation
None
Dim-Pro Plus (1 cap/day)
Ref range
Urinary Estrogen Metabolites (pg/ml)
2-OHE1
16-alpha-OHE1
780
307
378
458
2-OH:16-alpha OH E1 ratio
2.31
0.83
0.40 to 1.40
Case Study 4: Effect of Dim-Pro Plus on 2-OH estrone (2-OHE1) and 16-alpha OH estrone (16-alpha-OHE1) and
2-OH:16-alpha OH E1 ratio in a young premenopausal woman taking birth control pills.
Age 23
Present status: no breast cancer, on birth control for 4 years
Supplementation
Urinary Estrogen Metabolites (pg/ml)
2-OHE1
16-alpha-OHE1
None
92
342
I-3-Carbinol
139
525
Dim-Pro Plus (1 cap per day) 258
283
Ref range
Toll Free: 1 (800) 753-4145
Phone: (253) 875-0413
2-OH:16-alpha OH E1 ratio
0.27
0.26
0.91
0.40 to 1.40
Fax: 1 (888) 878-6193
www.medifood.info
KEEP OUT OF REACH OF CHILDREN
BioResponse DIM® and DIM-PRO™ are trademarks of BioResponse, L.L.C.
BioResponse DIM® is a patented, enhanced bioavailability, oral delivery
system for diindolylmethane (U.S. patent # 6,086,915)
(A patented, enhanced bioavailability complex containing min. 25%
diindolylmethane) Starch, diindolylmethane, vitamin E (d-alpha
tocopheryl succinate, [tocophersolan]), soy phosphatidylcholine, silica
®
Directions:
Take 1-4 capsules daily with food or as directed by a health care professional.
Do not use if tamper-evident seal is broken or missing.
Warning:
Do not use this product if you are pregnant, may become pregnant, or lactating.
Individuals taking prescription medications should consult with a health care professional
before using this product. A harmless but noticeable change in urine color may occur with
the use of this product. Do not use if tamper-evident seal is broken or missing.