Quadro® Comil® General Brochure

Q UA D R O P R O C E S S P R O D U C T I V I T Y S O L U T I O N S
For ov
For
over
er 30
30 ye
y ar
arss, Qua
Quadr
dro
o ha
hass ma
made
de a
an
n un
unpa
para
pa
ra
rall
allllel
eled
el
ed
d ccom
ommi
om
mittmen
mi
tmentt to
to d
del
eliliver
verin
ing th
ing
the
e hi
h ghes
gh
hes
estt pr
prod
oduc
ductitition
on
efff ci
effi
cien
enci
cies
es,, pr
prod
duc
uctt qu
quallitty an
and consiistenccy to
om
mar
arke
kett le
ke
ead
ader
e s in tthe
er
he Pha
h rm
rmac
aceu
ac
eutitica
c l, Foo
ca
ood
d, Fin
ine
e Ch
C em
emic
ical
al,l
Personal Care and Cosmetics industries worldwide.
Quadro Comil
®
®
A D VA N C E D
SIZE
REDUCTION
•
PERFORMANCE
&
FLEXIBILITY
With the engineering experience gained
from developing reliable application-specific
solutions for major processors in more than
80 countries, our knowledge of size
reduction and dispersion is unmatched.
In fact, meeting the evolving needs of our
customers drives the development of some
of the industry’s most advanced processing technologies and
systems – such as the Quadro
o® Comil®, Quadro
o® FlexSift,
®
®
Q adro
Quadro
o Fine Grind,
Grind Quadro
Q adro Ytron
n iin
in-line
liline mixers,
mixers
i
dispersers
di
and emulsifiers, Quadro
o® ShearFX, Quadro
o® HV-Emulsifier and
Quadro Vac ® vacuum transfer systems.
Since 1976, Quadro has led the industry in research &
development. Through the Quadro R&D Test Center we work
directly with our customers to run realworld tests of their processes on the latest
Quadro equipment. The result has been
technical breakthroughs that have
changed the way many of our customers
manufacture, and led to new global
processing industry standards.
As the world’s leading supplier of size reduction technology –
with a vast global network of agents, distributors, OEMs and
partners – Q
Quadro
d provides
id a level
l l off service
i and
d technical
h i l
support that is unequaled in the industry. Our passion for
technology is exceeded only by our dedication to meeting the
needs of our customers.
QUADRO GLOBAL LOCATIONS
World Headquarters
S I Z E
R E D U C T I O N
•
F L U I D
Representative Locations
M I X I N G
•
Local Testing Capabilities
P N E U M A T I C
T R A N S F E R
L O C A L R E P R E S E N TAT I V E
613 Colby Drive
Waterloo, ON, CA N2V 1A1
1925 West Field Court, Suite 200
Lake Forest, IL 60045-4824
Canada & International T 519-884-9660
USA
T 973-376-1266
All Locations
F 519-884-0253
[email protected] • www.quadrocomil.com
CLINE12
Q U A D R O® C O M I L®
The Industry Standard for Over a Quarter Century
D Y N A M I C
U
Versatility and control
uniform size reduction, sieving, deagglomeration
generation introduced. Our latest inline designs
dispersion and mixing. In applications throughout the
incorporate a host of innovations that offer greater
Pharmaceutical, Food, Fine Chemical, Personal Care
application versatility along with easier cleaning
and Cosmetics industries, wherever process managers
and maintenance.
countries, the Quadro ® Comil ® is the
Over the past 30 years, the Comil ®’s industry
world’s leading technology for achieving
leadership has been reaffirmed with every new product
seek optimum process efficiency and product
consistency – that’s where the Comil ® is hard at work.
Quadro invented the original conical mill in 1976. Though
manufacturingg q
qualityy that ggive yyou maximum
simple in principle, the
was a revolutionary
2. The product is forced outward to the screen
surface by centrifugal acceleration, ensuring
continuous delivery into the "action zone"
between the screen and impeller.
3. In the "action zone" the material is uniformly
sized and instantaneously passed tangentially
through the screen openings.
When you choose the Quadro ® Comil ® you can rely on
receiving the superior engineering and
Comil ®
1. In the conical screen chamber, a rotating impeller
imparts a vortex flow pattern to the infeed
product.
Maximum performance
Maximum processing efficiency
4. The finished product is discharged at the
bottom of the milling chamber.
uptime and yyield. What’s more,, everyy Comil ® is
concept that has since evolved into a global processing
backed by the highest level of application and
standard adopted by market leaders around the world.
te
echnical support, based on more
Today, the Comil ®’s proprietary, advanced size reduction
than a quarter century of
technology has been refined through thousands of
Quadro exxperience. Quadro ®
applications to deliver reliable scalability, repeatability and
Comil ® products
environmentally friendly performance. The result is
are paten
nted
superior product quality and maximum throughput for
worldwide
e.
The Quadro®
Comil ® comes
in 35 standard
models, available with
over 200 screen types and
dozens of different impellers –
the industry’s most extensive line
of conical milling equipment.
quick return on investment.
THE
Q U A D R O® C O M I L® H E R I T A G E
Revolutionary technology that has stood the test of time
1976
1977
1984
1990
Model 196
First Comil ® brought
to market
Model 197
Small production
model introduced
Model 194
Mid-size production
model introduced
Model U20
Comil ® underdriven
line established
P R I N C I P L E S
1996
Series 2000
Comil ® global design
2001
2003
Model F10
Fine Grind Series,
micron milling
Model U5
Pilot & Development
Scale Mill
2005
Model U3
First Scalable
R&D/Lab Model
Introduced
®
P
Q
ualityy engineered
g
for
Manufactured in stainless steel for
reliable, low-maintenance
sanitary operation and easy cleanability,
operation, the Comil ®’s
the Comil ® Overdriven can be flood fed
track record for high-efficiency inline
(control feeding is not necessary).
processing is unequaled across a vast
Milling action can be fine tuned
range of applications – from size
using a comprehensive selection of
reduction to mixing and dispersion,
interchangeable tooling, as well
bulk density adjustment to separation and
as speed variation.
reclaim.
R O V E N
S
I Z E
R
E D U C T I O N
T
E C H N O L O G Y
1
5
Low heat, low noise, low dust
Scalable performance
The original Comil ®’s innovative,
The Comil ® Overdriven is available
low-speed design applies an inherently
in five models, offering capacities
gentle action to the product, achieving
a Comil ® for delumping sodium and potassium
up to 120,000 lb/hr (54,500 kg/hr).
optimum particle granulometry while
chlorides, the results were impressive. Dust levels
Specialized performance options are also
generating limited or no heat, low
DELUMPING DOWN TO <500 MICRONS
4
"When we replaced our oscillating granulator with
available.
noise and minimal fines. In addition to
were minimized, and equally if not more important,
2
7
processing time was reduced by 50%."
Norgine Ltd., South Wales, U.K.
low energy consumption, the result is
To achieve the tight particle size range required
a consistent, high-quality end product,
to produce their "Movicol" product, Norgine had been
even with heat-sensitive materials.
3
delumping chlorides in small batches using an
oscillating granulator. The Comil ® performed so well,
that they purchased a second unit for sizing dried
6
S P E C I F I C A T I O N S
granules for their "Camcolit" and
"Destolit" tablets.
METHOD
OF
OPERATION
Sodium and potassium chlorides are dried on
trays, then tipped into the inlet of the Comil®
FEATURES
1 Infeed chute can be customized to
1.
meet all proce
cess
ss ffee
eed
requirements (manual,
pneumatic or mechanical).
2 Machine housing with super2.
sanitary spindle assembly. Can
also be modified for clean-in-place
(CIP) operation.
Capacities are based on standard pharmaceutical placebo with 3% crystalline cellulose (CMC).
Capacities may vary significantly based on product characteristics, particle granulometry, inlet and
discharge conditions. Consult your local representative or Quadro for product testing.
(3)
For some products, capacities reach the following higher limits: (a)15,000 lb/h (6,800 kg/h), (b)35,000 lb/h
(15,900 kg/h), (c)60,000 lb/h (27,000 kg/h), (d)120,000 lb/h (54,500 kg/h).
(1)
(2)
3.
hroud
3 Swing-away discharge shroud
allows quick cha
changeover of
screens, impellers, customized
tooling for special applications.
Also allows for easy cleaning. Can
be custom engineered to fit any
process or collection vessel.
4.
ntire
e mac
a hi
hin
ne available in
4 En
v riiou
va
o s gr
grad
ades
ess of stainle
nless steel
nle
and
an
d sp
pec
ecia
ialt
lty alloys.
5 Be
5.
B lt guard
r – ccom
ompact for easy
removal, gas
asketted
k
for added
p ot
pr
otectiion
n of drive components.
(See
ee
e iinset for illustration of direct
driven model.)
d
6 Safety features to meet all
6.
international safety guidelines and
standards.
7 Stainless steel motor shield for
7.
sanitary applications.
through a specially designed feed hopper,
reducing dust levels to an absolute minimum.
Comil ® Model 197 S
with standard feed hopper
®
H
B
Comil ®
Available in four models, the
revolutionary technology
Underdriven is scalable in capacity from
as our overdriven model, the
several ounces (grams) to 35,000 lb/hr
Underdriven provides
C
A PA C I T Y
I N
A
The Comil® Underdriven’s cGMP
design and minimum surface
area of contact make it easy
to clean, as well as offering
quick disassembly and
assembly for autoclave
applications.
Comil ®
ased on the same
I G H
C
O M PA C T
F
O O T P R I N T
S O L U T I O N
(15,900
(15
900 kg/hr)
kg/hr).
all the features and options of the
original Comil ® – with additional
Innovative "quick change"
tooling
advantages, including easier
Fine tuning the mill for optimum
inline integration.
granulometry is simplified by means
Compact design, increased
throughput
of an innovative spacerless design,
This mill’s advanced, compact design
impellers and screens. Specialized
and extremely short head height
tooling is available to meet all process
7
2
4
3
which allows for quick changeover of
provide for easy integration into
requirements. A variable-speed feature
processing environments where head
provides for even greater control of
room is limited. A large-diameter infeed
6
SAFE, VERSATILE INERT MILLING
"Not only did the Quadro ® Comil ® meet our most
stringent requirements for use in hazardous
locations, the portable design of the system
allowed for remarkable flexibility, along with easy
operation and cleaning."
Pfizer Inc., Michigan, U.S.A.
5
1
process performance.
and “straight through” housing (with no
8
offset between inlet and
When Pfizer required a portable inert mill for use
throughout their new, state-of-the-art research
facility in Michigan, they turned to Quadro.
We engineered a custom solution that included
an air-purge electrical panel, inert gas inlet and outlet
ports, a closed-loop oxygen control system, and infeed
chutes for both inline and hand feeding.
outlet) promote unhindered inline
product flow for quicker discharge.
S P E C I F I C A T I O N S
METHOD
FEATURES
from
100 gm or
3 oz batches
9
229
11
179
2.55
65
.33
0.246
0.5
Capacities are based on standard pharmaceutical placebo with 3% crystalline cellulose (CMC).
Capacities may vary accordingly based on product characteristics, particle granulometry, inlet and
discharge conditions. Consult your local representative or Quadro for product testing.
(3)
For some products, capacities reach the following higher limits: (a)15,000 lb/h (6,800 kg/h),
(b)35,000 lb/h (15,900 kg/h).
(4)
U3 model is generally designed for lab and research purposes.
(1)
(2)
P R O F I L E
1 Extremely short housin
1.
ng he
heig
ight
ig
ht
for installation in produ
ucti
uc
ucti
tion
on
environments where space
pace is
limited.
2.
2 Large infeed diameter for up to
50% higher capacity than
conventional mills.
55. Ea
Easssy-clean,
y
sanitary de
e
esign
inclludes all sanitary
ry
connections and ultr
con
tra-sanitary
gearbox. Fully automatic
au
CIP capability a
available.
6 Quick chan
angeover of screens
and imp
mpellers, no special tools
requ
equired.
3 Spacerless design provides
3.
optimum impeller/screen
gap for superior particle
cle
ggranulometry
ranulometry and performance.
7 Inlet and outlet can be
7.
customized to fit any
process conditions.
4 Minimum surface area
4.
resulting in maximum product
flow and lower cleaning costs.
8.
8 Safety features to meet
all international guidelines
and standards.
OF
OPERATION
Prior to starting, the Comil ® is purged with N2 in
order to produce inert operating conditions. During
milling, should the oxygen level rise to the preset
maximum, the N2 purge is activated
automatically to halt the rise. Should
this continue, an alarm will sound and
the Comil ® will shut down.
Comil ® Model U10
Leading Expertise Gained Through
More Than 20,0
000 Applications
F
Comil ®
or more than 30 years,
Processing knowledge
Quadro has been continually
In designing for your application,
refining and improving
Quadro engineers draw on one of
technology. During this time, we
the most comprehensive databases of
have partnered with our customers,
processing knowledge. Our industry-
successfully developing thousands of
leading global test center includes a full
custom applications to provide
range of the latest lab equipment,
increased productivity, versatility
a product preparation area and a state-
and reliability.
of-the-art analysis area, as
A
P P L I C A T I O N
DRY MILLING
SIZE REDUCTION
Dry granulation in tablet manufacturing. Dry
solubles. High-throughput bulk density fine tuning.
Sizing dry granules. Sizing compacted product.
WET MILLING
SIZE REDUCTION
DRY MIXING
DISPERSION
Application problem solving
well as a fully equipped customer
Unparalleled experience enables us
training and testing facility, all
to offer a level of application problem-
dedicated to optimizing your
solving expertise second to none –
production process.
whether you’re reclaiming
pharmaceutical powders from gelatin
capsules, performing closed-loop inert
milling, granulating freeze-dried food
products with minimum retention time or
delumping wet, sticky materials.
Try before you buy
To enable our customers to evaluate the
Quadro ® Comil ® in a real-world
production environment, we offer a
H O W C A S E
PHARMACEUTICAL
Size
Siz
i e redu
ducti
cttiion
ccti
on of
of com
om
mpac
paccted
pa
tee
tted
sluuggss (sh
(ss own
ow
w )
Siz
Size
Si
ize red
ed ct
edu
ction
cti
tiion
on of "ri
ribbo
ri
ibbbo
bonns"
bo
ns" frrom
m
the
hhee ro
rollle
leer
er coomp
ompac
act
c orr
ct
S ing
Si
Siz
ngg dr
dry ggran
ran
ran
anula
ulaatioon ttoo idea
ulatio
deaal
ppar
pa
artic
icllee siz
sizzee for
or tab
tablet
etttin
ettin
ing
Siz
Siz
i ing
ng off innjec
ng
ectab
t ble
lee dru
dru
r g powd
powd
ow
wdeerr
wd
iinn ste
st ril
ri e prod
ri
roduct
odduuc
uct
ction
ion
Geenntle
G
Gen
tlt si
tle
size
ze red
edduuct
educt
uctiion
on of
on
of en
enzy
zym
ymes
es
S ing
Siz
ingg laacto
toose
se and
n ot
othe
other
her su
her
suggar
aarrs
FOOD
Pro
roduc
ducing
duc
ucing
ng cr
ccrumb
ruumb
m s from
from
om
m dr
dryy cere
real
a
al
oorr bre
brreeadd for
fooor fo
food
od cco
coa
oatin
ings
in
ngs
gs (sh
sshown
wn)
n)
Siz
izing
izing
n cchhili
ng
hililii pe
peppe
peers
rs int
intoo flak
akes
ak
e
F ne tun
Fin
une
ne bbuulkk den
denssiti y of
densit
of noonn dairy
daai
dai
a ryy
ccre
reame
reeame
am r
Pow
owder
de ize
de
der
zee sh
s ort
o eni
ning fla
flakes
llaakes
k
ke
Ge ttltle
Gen
Ge
l si
s ze
ze red
reduct
educt
ucction
ionn off fr
freez
eee eeez
e
dried
dri
ed bac
a tterriiaa cul
ac
cuultur
ttur
uurre
Sizze red
S
eedu
duce
ce he
hher
e bs
bs for
o ex
extra
trr ctition
t onn
GENERAL • COSMETIC • CHEMICAL
Siz
S
izze
ze reedu
duce
du
ce m
ce
min
innera
ner
era
rral salts
alts (s
alt
(shhoown
ow
w ) Dri
wn
D edd cit
c ric
ic ac
acidd m
miillin
mil
inng
Urraanium
U
Ura
nniu
iuum diox
diox
oxxiide
dee mi
milli
llliing
ng
ng
S zee redu
Si
Siz
d ce
ce yew
w needl
ne
neeedl
edddlleess
Unifor
Un
Uni
orm
ormly
mllyy si
mly
sizzee wet
weet gr
gran
anu
nulation
nu
lat
ationn foor effif ccie
at
iieent
entt dry
drying
ngg (sh
sshhown
how
own
w )
Siz
S
Si
izze redu
reedu
ducee ffro
frrooze
zen
een bl
bblood
loo
o pl
ood
p asm
plasm
ma
(shown
own
wn))
Siize redu
Siz
edd cee ber
berrie
be
riess forr yoggurt
rie
rtt filli
fif lli
lllliing
ng (sh
Produc
Pro
duu e lump
duc
mp-fr
-frree
ee tof
t u crrea
e m
ea
Miill sooakkedd soya
M
Mil
soy
oya bea
ean
aanns ttoo prod
prod
oduce ssoy milk
od
i k pprrodu
oducctt
od
Deeaggl
Dea
ggg om
ome
m rat
rate
aatte cent
cen
ent
ntrrififug
nt
uge
g ca
cakee (s
(sh
show
own
wnn))
w
Wet co
Wet
c re
re dishwa
diishwa
dis
waashe
w
she
h r dete
eteerge
erge
rgge
gent
n
Hom
Ho
H
om
mog
ooge
gene
ge
neo
eeoousl
eousl
usly
us
ly disp
spper
spers
ers
ers
rssee pigm
ggm
men
ents in tab
ent
abl
bleet
ets
ttss ((sh
shoownn)
Hooom
H
Hom
mooge
moge
ogggeeneo
eeoousl
ussly disp
disp
issp
s eers
rse fatt
ggloobules
buu es
bul
es iinn bakery
bakeryy mi
bak
mixxes
mixes
eess (shown
(shhown
ow
w )
Geenntle
Gen
tltlee bl
b eend
blend
nndding
n of
ng
of sp
s ice
iccee mi
mixe
xxes
eess
D perse
Dis
per
errse
se nut
nnuutrie
ieent
nts
tts in ce
cerea
reea
eal
Unn for
Uni
U
foormly
mllyy di
d spe
peerse
rsee sp
s ice
ice, flav
lavvors
rrss
or pig
or
igmen
gmen
meents
ts iinn ppud
puuddding
din
i g mixe
in
xxees
H mooge
Hom
ogge
geneo
eneo
neeousl
u y disp
us
speers
spers
sp
rs
rse
se bin
inder
ind
nderr peaarl
r and
ndd
ppig
igmen
mennts
ttss inn blu
bl sh
sh and
ndd eyye shhad
haadow
dow
w ppow
wdder
wder
deeerrs (sh
(sshhown
ow
own)
wn)
Delump ra
De
Del
raw mate
teria
te
rials
ria
ls exi
ls
e tin
ex
tinng bulk
bul
u k bi
ulk
bins
ns (shown
ns
( how
(sh
own)
own
wn)
Seeppara
Sep
Se
raate
te ra
rrai
aisin
in cclump
mps
mp
ps int
nto
ttoo
uunddama
dama
maged
gee indiv
inndi
divvidu
d al
du
al pi
pieces
pie
ceeess
(shhown
(sh
(shown
w )
Dea
D
eaggl
agggl
ggg ome
omerat
mera
rat
aatte chee
eesee ppow
ow
wder
er
froom spra
spra
p y drye
y r
ye
yer
Si e choc
Siz
ho oola
ollattee mil
m k crum
umb prio
um
prio
ioor
to fla
flaker
kker
er
er
Seeeppara
Sep
rraatee ddri
r ed
e fru
frruitit
witthou
w
tho
houut dama
hou
dama
maaggee
m
Deaggl
De
Dea
ggglomerat
ggl
ome
meerate
rat
ra
ate pigm
gmen
gment
ents (sh
ent
s ow
own
w )
wn
Del
De
eelump
um
m de
deter
tergen
te
ter
ergent
gen
gen
e t aggl
agggl
gggglome
ome
meera
rat
rates
ates
es
Tablet
Ta
Tab
et reecla
claim
laim
m (s
(shown
(sh
shown
ow )
Coonnten
Con
teennts
ts froom caps
psuule
psule
ulless
Injjeect
In
Inj
ecctabl
abb e drug
ugg ffrrom
m gla
glass
ss syr
syyyrring
ing
ngges
e and
annd bo
an
bottl
tttless
tt
ttl
Pow
ow
wder
deeerrize
izee coook
ize
oki
kkiieess (in
inclu
lluudin
di g crea
di
reeam
fiiilllled
ffil
edd) (sh
ed)
(sshown
wnn)
G nnol
Gra
noola bars
a into
ar
intoo uund
ndama
magedd ppiiece
m
eces
eces
ece
Haar
Har
ardd/s
/s
/sof
oftt ca
c ndy
ndddyy innto
to ppow
wder
e or syyru
ruupp
rup
Pootato
Pot
oottaato
too cch
chips
hips
ipss, naach
acchoos,
oss,
s, ta
taccoo she
hells
he
lls in
lls
into
too
ppiiece
pie
ces
eess, crum
umbs,
mbs,
b ppo
bs
powde
wde
w
de
der
Size reduction and milling of wet or soaked
products to produce liquid with wet suspended
particulate. Powders into pastes. Wet blending.
Uniform sizing of wet granulation in tablet
manufacturing.
In our state-of-the-art testing center, Quadro performs advanced application testing and
analysis for our customers, at no charge.
S
Ideal for a broad range of dry mixing, finishing and
dispersion tasks. Lump-free homogeneous blending
to precise size requirements. Low heat buildup and
precise screen size ensure complete dispersion at
desired particle size.
DEAGGLOMERATION
DELUMPING & SEPARATION
Reducing difficult, sticky, heat-sensitive
agglomerates into pieces, crumbs or powders of
uniform size, continuously without excessive heat
buildup or screen blockage. Preserves quality of
fragile products. Replaces labor intensive,
expensive manual processes.
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"try before you buy" trial tooling and
rental program. Our confidence in the
RECLAIM
Comil ®’s ability to meet or exceed your
expectations, and perform
trouble-free processing, enables us
to offer a full money-back guarantee.
Gentle breaking action enables the Comil ® to
powderize heat-sensitive products such as
shortening and cream filled products. Hard,
compacted products can also be size reduced with
minimal fines.
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Custom Engineered Solutions
Tailored to Your Specific Processing Needs
Q
uadro excels in custom
meet your specific performance and
engineering. From simple
volume demands. For example, by
dimensional changes
interchanging tooling you can alter size
of our standard models to complete
reduction, blending or dispersion
prototype development, we offer
parameters to handle varying product
unmatched application expertise that
requirements, or even completely
enables us to build to your exact
different applications, all using the same
process requirements.
machine.
Performance, repeatability,
flexibility
An array of specialized options
Our experience in conical-screen size
of specialized options for customizing
reduction is unequaled. Every
Comil ®
We offer a comprehensive selection
is
engineered for superior performance and
reliability. No matter what your
application, the Comil ® consistently
the Comil ® to your exact needs.
Options include:
An inverted fluid-bed dryer bowl directly
discharges into a Comil ® U30 on a portable
stand, feeding a stainless steel drum.
• Special materials and surface
finishes
• Portable, height-adjustable and sliderail mounted frames
The unmatched flexibility of the Comil® design enables
Quadro to provide highly customized solutions for integration into your most demanding processing environments.
• Pressure-vessel, explosion proof, fully
inert, totally contained glove-box and
TYPICAL
SYSTEM
CONFIGURATIONS
cryogenic mill designs
• Computerized control for complete
process monitoring and reporting.
Available in USDA approved, CIP, SIP and
WIP designs, the Quadro ® Comil ®
conforms to all international standards
including UL, CSA and Halal
Quadro custom engineered this integrated
milling solution incorporating the Comil®
with a Carlisle Extract crossflow system.
certifications, and complies with
OSHA, FDA, CE, cGMP, ATEX and
Pressure Vessel (meets ASME code)
Integrated Wet Sizing
Bulk Discharge
g Station
21CFR11 guidelines and directives.
delivers the batch-to-batch repeatability
Detailed documentation, such as
required to comply with the most
compliance certificates and IQOQ
demanding FDA standards.
documents, is available in various
Since 1976, the Comil ® line has
Milling and Blending
languages to make your validation
process easier.
expanded to include thirty-five base
models. Model selection is tailored to
Dry Milling and Conveying
Finishingg ((Feed from Blender))
Complete Inert Milling System
Hazardous
H
d
Containment
C
t i
t