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biologist-archive - King Edward VII Academy
TheBiologist The society of biology magazine ■ ISSN 0006-3347 ■ societyofbiology.org Vol 61 No 1 ■ FEB/MAR 2014 the future of fuel Could biofuel from algae reduce our need for oil? URBAN ENVIRONMENT MICROBIOTA INTERVIEW DEEP ROOTS Saving trees during urban development GUT INSTINCT The body's bacteria and its impact on our health AGE OF SUCCESS Linda Partridge on the biology of ageing New from Garland Science EPIGENETICS Lyle Armstrong The concept of epigenetics has been about since the 1940s, but it is only in the last 10 years that research has shown just how wide-ranging its effects are. It is now a widely-used term, but there is still confusion surrounding what it actually is and does. Epigenetics is a new textbook that brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It is a valuable source of information about all aspects of the subject for undergraduate students, graduate students, and professionals. Paperback • £45.00 2013 * 978-0-8153-6511-2 300pp • 150 illus Contents: Topics Include: • The two forms of epigenetic modification, DNA methylation and histone acetylation, and how they take place. • How epigenetics controls cell function, including cellular differentiation and the role of epigenetics in stem cells. • The role of epigenetics in disease, including cancer and mental health, where there is clear evidence of epigenetic involvement. Chapter 1. Introduction to the Study of Epigenetics Chapter 2. The Basis of the Transcription Process Chapter 3. DNA Packaging and Chromatin Architecture Chapter 4. Modifying the Structure of Chromatin Chapter 5. DNA Methylation Chapter 6. Post-Translational Modification of Histones Chapter 7. Histone Modification Machinery Chapter 8. LocusSpecific Control of Histone-Modifying Enzyme Action Chapter 9. Epigenetic Control of Cell-Specific Gene Expression Chapter 10. Epigenetic Control of the Mitotic Cell Cycle Chapter 11. The Epigenetic Basis of Gene Imprinting Chapter 12. Epigenetic Control of Cellular Differentiation Chapter 13. Reversibility of Epigenetic Modification Patterns Chapter 14. Epigenetic Predisposition to Disease and Imprinting-Based Disorders Chapter 15. Epigenetics of Memory, Neurodegeneration, and Mental Health Chapter 16. Epigenetics of Cancer www.garlandscience.com/epigenetics NEW EDITION NOW AVAILABLE Essential Cell Biology, 4th Edition Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, Walter 978-0-8153-4454-4 • £105 • Hardback 978-0-8153-4455-1 • £53 • Paperback 865pp • 860 illus • November 2013 TheBiologist the SOCIETY OF BIOLOGY MAGAZINE Volume 61 No 1 February/March 2014 Contents 20 24 28 12 16 In this issue 8 Opinion: Revolution on the reserves Brian Moss argues that a more radical approach to conservation could help halt global warming. 12 Gut feeling Lauren Hoskin looks at the microbes living inside us. 16 The root of the problem Chris Baines explains how large tree roots are mapped and protected during building work. 20 Algal biofuel – in bloom or dead in the water? TheBiologist THE SOCIETY OF BIOLOGY MAGAZINE An expert panel discusses if biofuels from algae could eventually replace oil. 28Life goes on Professor Dame Linda Partridge, an expert on ageing, on staying healthy for longer. ISSN 0006-3347 ■ SOCIETYOFBIOLOGY.ORG VOL 61 NO 1 ■ FEB/MAR 2014 THE FUTURE OF FUEL 24 Force of nature Sue Nelson visits a centrifuge to explore the physiological effects of G-force. ■ MICROBIOTA INTERVIEW GUT INSTINCT The body's bacteria and its impact on our health AGE OF SUCCESS Linda Partridge on the biology of ageing 00_BIO_61_1_COVER.indd 1 4Society news 37 Members 40Branches Regulars Could biofuel from algae reduce our need for oil? URBAN ENVIRONMENT DEEP ROOTS Saving trees during urban development Cover photo: Lawrence Naylor/Science Photo Library News 30/01/2014 15:22 3Nelson’s column 10 Policy update 32Spotlight 34Reviews 46Museum piece 47Crossword 48Final word Vol 61 No 1 / the biologist / 1 THE BIOLOGIST Vol 61 no 1 February/March 2014 Contacts Editorial STAFF Editorial Board Director of Membership, Marketing and Communications Jon Kudlick MSB Editor Sue Nelson @ScienceNelson Managing Editor Tom Ireland MSB [email protected] @Tom_J_Ireland Communications Assistant Karen Patel AMSB [email protected] Susan Alexander BSc PGCE CBiol CSci MSB MRSPH FRGS J Ian Blenkharn MSB FRSPH Phil Collier MSc PhD CBiol FSB FLS FHE Cameron S Crook BSc MPhil CBiol MSB MIEEM FLS Rajith Dissanayake MSc PhD FZS AMSB Catherine Duigan BSc PhD FSB FLS John Heritage BA DPhil CBiol FSB Sue Howarth BSc PhD CBiol FSB Allan Jamieson BSc PhD CBiol FSB Catherine Jopling BSc PhD MSB Leslie Rose BSc CBiol FSB FICR MAPM For membership enquiries call 0844 858 9316 [email protected] For subscription enquiries call 020 7685 2556 [email protected] Facebook “f ” Logo TWITTER @Society_Biology RGB / .ai Facebook “f ” Logo iNteRVieW PRofessoR JANe fRANCis the new director Tom Ireland meets tic Survey, of the British Antarc Professor Jane Francis warm. You can just it’s actually quite serene Jane n October Professor sit and watch an amazingly with the as director Francis took over and tranquil landscape, Survey, off icebergs and the of the British Antarctic sunlight glinting has led the you don’t want to an organisation which odd bird call. Then and research in in the world. UK’s exploration be anywhere else than 60 years. the region for more ? ist and geologist, As a palaeobotan Any hairy experiences health and research uses take first aid and Professor Francis’ We not to understand very seriously so I’ve fossilised vegetation has changed safety calls. The how the Earth’s climate really had any close was when I throughout history. scariest experience (Norway) was working on Svalbard bear academic work a polar A large part of your a few years ago and for fossils in to our camp. In the has involved looking came quite close Antarctic. asleep in a gully for fell he both the Arctic and end working in of our camp Presumably you enjoy a few hours in front ts? you do have to polar environmen and then left, but done about I absolutely do. I’ve be very careful. and six 10 seasons in Antarcticaand they polar-based field trips to the Arctic, How did you get into to work. It’s place? are fantastic places research in the first that is so working on amazing to go somewherea leaf that As a geologist I started and did a find PhD remote and cold and fossil plants for my of the Jurassic was once almost shows the climate project on the rocks started working tropical there. coast in Dorset. I up camp in the leaves and Whenever you set there on fossil trees, can that ing ancient field – a huge operation always a pollen and reconstruct in – there’s Then, while working take a day or two or ship forests. an invitation helicopter had I the moment when central Australia, Geological realise it’s very leaves, when you from the Canadian just a small group see these amazing quiet, and you’re Survey to go and discovered a very isolated of people alone in fossil forests they’d They were of months. place for a couple up in the high Arctic. – they beautiful It’s generally a very spectacularly preserved turned place – and and extremely humbling fierce hadn’t been petrified find. pretty usually the climate can be to stone like you’d speck in this the wood and and you’re just a tiny You could saw open But I’ve been in could pick the awesome landscape. it would burn; you when the sun trickle through the Arctic peninsula leaves up and they’d the wind drops is shining, and when I 28 / the biologist ThE TwIsTs aND TurNs of DNa / Vol 60 No 6 I No 6 Vol 60 No 6 / the The Biologist is produced on behalf of the Society of Biology by Think Publishing Ltd. 124-128 Barlby Road London W10 6BL www.thinkpublishing.co.uk 020 8962 3020 biologist / 29 Design Alistair McGown Production editor Clare Harris Sub editors Sam Bartlett, Sian Campbell Publisher John Innes [email protected] The ability to look at the atomic level has been structure of DNA at the key to understanding miraculous molecu this le, as scientist and David Goodsell discove illustrator rs n 1953, Watson and Crick presented their model for the DNA double helix, revealing the way genetic information is held in a cell. In the years since, DNA has proven to be a lively molecule that is looped, unwound, copied, repaired, edited, chemically modified, more recently, engineered. and A closer look at DNA’s atomic structures (and its related cellular partners) has since revealed much more about the complex workings of this amazing molecule. Early work on DNA structure used DNA that had been isolated from cells. Fibres of this natural DNA diffract x-rays into a characteristic pattern – the classic helical structure proposed by Watson and Crick, known as a B-helix. A truly glimpse at DNA, however, atomic wait for several decades. had to for the chemical synthesisTechniques of small pieces of DNA, with exact nucleotide sequences, made this possible. These well-defined pieces of DNA can be coaxed to form single crystals, which provide much more x-ray diffraction patterns detailed (as shown in Fig. 2 overleaf), which analysed to determine can be the each atom in the molecule.location of Since then protein and sequencing technology DNA has improved rapidly, and the amount of structural data on DNA other molecular machines and has grown enormously 2014 . The VOL 60 NO 6 ■ DEC 2013/JAN either on its own Data Bank has become Protein or complexed with the primary proteins or drugs. archive of atomic structures for biological molecules Here is just a little of the and now structural biology for95,000 contains almost Shortlisted of DNA entries, been discovered thanks that has 1,500 BUSINESS of which include DNA, BEST to our ability to view its atomic structure. & PROFESSIONAL TheBiologist DEPICTING DNa based on information gathered from x-ray crystallography, Nmr it is unwound from spectroscopy and nucleosomes, the As well As his work two electron microscopy. strands are separated, as and the enzyme DNa biologist, David goodsell a molecular The illustration shows polymerase (large employs various complex in magenta DNa in the nucleus artistic techniques stored as chromatin, at the centre) builds new to visualise biological a compact form with strands (shown in white) macromolecules. here DNa (shown here in to complement the he uses watercolour turquoise) wrapped original strands. ■ ISSN 0006-3347 ■ SOCIETYOFBIOLOGY.ORG to show the around OF BIOLOGY MAGAZINE SOCIETY THE shapes histone proteins (blue) David also develops and sizes of molecules, graphics programmes to form a long chain of nucleosome to visualise individual s. When DNa replicates, molecules, as seen in figures 2 and 4. 18 / the biologist / Vol 60 MAGAZINE Fig. 1. The DNA polymerase from the hot spring bacterium Thermus aquaticus is widely used in the lab for the polymerase chain reaction Non-member rates: £120.00 the biologist / TheBiologist Th WIeB ioElogist LDLIF WARNING 19 ISSN 0006-3347 THE SOCIETY OF BIOLOGY MAGAZINE THE SOCIETY OF BIOLOGY MAGAZINE ■ ■ ISSN 0006-3347 ISSN 0006-3347 ■ ■ SOCIETYOFBIOLOGY.O RG VOL 60 NO 5 SOCIETYOFBIOLOGY.O RG VOL 60 NO 2 ■ OCT/NOV 2013 EVENTS ■ CALENDAR APR/MAY 2013 INSIDE INTERVIEW DIGGING DEEP How disease from domestic animals could wipe out iconic endangered species LIFE IN FOCUS 2013 Stunning images from our 2013 photo competition STRUCTURAL BIOLOGY EDUCATION INTERVIEW DNA DISCOVERIES Moving beyond the double helix LABS ONLINE Can practical science be taught remotely? POLAR PIONEER Jane Francis on Antarctic exploration Advertising in The Biologist represents an unparalleled opportunity to reach a large community of professional biologists. For advertising information contact Tom Ireland [email protected] 020 7685 2556 TV's Alice Roberts talks anatomy and archaeology 28/11/2013 10:23 00_BIO_60_6_COVER.indd 1 2 / the biologist / Vol 61 No 1 The Society permits single copying of individual articles for private study or research, irrespective of where the copying is done. Multiple copying of individual articles for teaching purposes is also permitted without specific permission. For copying or reproduction for any other purpose, written permission must be sought from the Society. Exceptions to the above are those institutions and non-publishing organisations that have an agreement or licence with the UK Copyright Licensing Agency or the US Copyright Clearance Center. Access to the magazine is available online; please see the Society’s website for further details. BREAKING THE ICE Professor Francis among emperor penguins in the Antarctic molecular biology DNa’s atomic structu re Submissions of interesting and timely articles, short opinion pieces and letters are welcome. Articles should be aimed at a nonspecialist audience and convey your enthusiasm and expertise. Instructions for authors are available on the Society’s website or on request from the editorial office. Contact [email protected] © 2014 Society of Biology (Registered charity no. 277981) BLOG societyofbiologyblog.org A Window on the Life Sciences The Biologist is a bi-monthly magazine (published six times a year) that covers the full richness and diversity of biology. Science is brought to life with stimulating and authoritative features, while topical pieces discuss science policy, new developments or controversial issues. Aimed at biologists everywhere, its straightforward style also makes it ideal for educators and students at all levels, as well as the interested amateur. Views expressed in this magazine are not necessarily those of the Editorial Board or the Society of Biology. RGB / .ai FACEBOOK www.facebook.com/ societyofbiology TheBiologist Society of Biology Charles Darwin House, 12 Roger Street, London WC1N 2JU Tel: 020 7685 2550 Fax: 020 3514 3204 [email protected] www.societyofbiology.org MYCOLOGY RICH PICKINGS Exploring treasures in the fungal kingdom 00_BIO_60_5_COVERS_V2.indd 1 GENETICS CRACKING THE CODE RESEARCH FACT AND FISSION Using neutrons to study biomaterials BIOPHYSICS QUANTUM BIOLOGY BIOGRAPHY ALFRED RUSSEL WALLACE The legacy of a great Victorian scientist RESEARCH 19/09/2013 10:28 A Nelson’s Column few years ago I travelled to the Outer Hebrides to report on how an introduced species – hedgehogs – had affected local wildlife. Driving through the island of South Uist admiring Arctic skuas and red-legged oystercatchers along the coast, something about the scenery began to bother me. Something I couldn’t quite figure out. Then it dawned on me what was different about the landscape: there were no trees. It’s hard to imagine a world without trees but South Uist comes pretty close. In the same way as those who live by the sea become uneasy when landlocked, if you live among trees their absence can be uncomfortable. It’s not simply an aesthetic issue; trees are often referred to as the lungs of our planet, helping the Earth breathe by converting carbon dioxide into oxygen. The benefits of trees in urban areas are both environmental and psychological. Seeing green leaves amid concrete is uplifting, while mature tree cover plays a role in intercepting heavy rainfall and reducing the risk of flash flooding. But trees come with roots, and protecting the root system can be challenging for developers and utility providers who also want to fix water pipes, maintain sewers, and install or repair cables. On page 16, environmental campaigner Chris Baines discusses problems and solutions when building around the living infrastructure of trees. If the sight of trees lifts the heart, a good night’s sleep is often key to enjoying your day. However, Lauren Hoskin’s revelation (page 12) that we go to bed with 100 trillion microbes inside our intestines was personally unnerving. As someone with an ‘out of sight out of mind’ approach to If we all live longer it will put even more pressure on the planet microbes, I had to overcome a natural reluctance to read further. Fortunately I did since Lauren celebrates the positive effects these tiny organisms have on our health. When it comes to prime specimens of health, fitness and adventure, astronauts are the whole package. But during the early days of spaceflight, no one knew what the body would experience and so the physical and mental tests were extensive and often unnecessary. One of the most enduring images is of an astronaut’s contorted face in a centrifuge. These tests continue today and are extremely important for pilots and astronauts. It has been a dream of mine since childhood to go into space – taking a spin on a centrifuge (page 24) to examine the effects on my body was the next best thing. Used by physiology students and pilots as a way of experiencing G-forces, the medical doctor at QinetiQ’s centrifuge informed me on my third spin that he knew what I was going to look like in 15 years. He shouldn’t count on it… The Biologist interview features Professor Dame Linda Partridge, a British geneticist who studies the biology of ageing. I’m not sure she’ll make me look any younger, but her research examines how a healthy lifespan can be extended in model organisms. If we all live longer that will put even more pressure on the planet’s finite resources. On page 20, Tom Ireland reports on whether fuel made from algae can reduce our dependence on oil. Who knows? Trees may help the planet breathe so maybe seaweed will save it too… Sue Nelson, Editor Vol 61 No 1 / the biologist / 3 Society News New training courses for 2014 TalkBiology launch The Society has launched a new online forum for science teachers and educators. TalkBiology went live during the Association for Science Education (ASE) Conference in Birmingham last month. Users can browse forums covering primary, secondary, and further education, send messages to other teachers, and create private groups to discuss certain topics. Members of the Society can access the forum using their existing login details and by visiting talkbiology.societyofbiology.org MBE for Society D policy adviser r Barbara Knowles FSB, senior science policy adviser at the Society of Biology, has been awarded an MBE in the 2014 New Year honours list for services to science communication and the environment. Barbara’s main professional interest is communicating science to non-specialists. As well as her work for the Society, she supports projects on meadow ecology, rural development and traditional agriculture in Transylvania, where she lives. “I’m delighted with this honour,” said Barbara. “It is especially welcome that the award recognises both my professional work in science policy and communications, and also my voluntary work As well as her work for the Society, Barbara supports projects in Transylvania Dr Barbara Knowles has been recognised for her professional and voluntary work 4 / the biologist / Vol 61 No 1 NEWS IN BRIEF to protect and learn about the outstanding but threatened environment in the eastern Carpathians of Transylvania.” Barbara, who was diagnosed with motor neurone disease in 2008, is now unable to move and will soon lose the ability to speak. “I’m really lucky to be able to do both jobs, with fantastic colleagues in London and Romania, despite being increasingly disabled with motor neurone disease,” she added. “A combination of computer technology, an off-road wheelchair and supportive friends and careers makes it possible to enjoy life, by doing interesting work which I believe to be important and valuable.” Dr Mark Downs, chief executive of the Society, said: “Barbara has used great skill and knowledge alongside incredible drive and determination to make a difference to sustainable development, inspiring others to take up the challenge.” www.societyofbiology.org/news SOCIETY PRESENTS WITNESS TO PARLIAMENT T he Society has expanded the range of training and courses it offers members, with innovative courses such as microscopy art and drug discovery set to be introduced later this year. The Society’s training programme aims to provide a range of skills for all interests and competencies, from enthusiastic amateurs to high-level professionals. Seven of the 12 courses scheduled for 2014 are new with planned courses including science photography, an introduction to science policy, Wildlife artist Cath Hodsman, whose work is pictured above, will run a microscopy art course in March OUR SURVEY SAYS… T hank you to all the members who completed The Biologist readership survey at the end of last year. It’s great to see that again the response to our survey has been overwhelmingly positive. Results show the magazine is still a crucial way for us to communicate with our members, with almost 90% of members saying that they read the magazine regularly, and the number of people who read every issue rising slightly to 81% from 80% in 2012. Over 93% of readers think our articles are good or excellent; over 91% think it is well written and easy www.societyofbiology.org/news Results show the magazine is a crucial way to communicate with members TheBiologist THE SOCIETY OF BIOLOGY MAGAZINE ■ ISSN 0006-3347 ■ SOCIETYOFBIOLOGY.ORG VOL 60 NO 6 ■ DEC 2013/JAN 2014 Shortlisted for BEST BUSINESS & PROFESSIONAL MAGAZINE LIFE IN FOCUS Stunning images from our 2013 photo competition STRUCTURAL BIOLOGY EDUCATION INTERVIEW DNA DISCOVERIES Moving beyond the double helix LABS ONLINE Can practical science be taught remotely? POLAR PIONEER Jane Francis on Antarctic exploration 00_BIO_60_6_COVER.indd 1 28/11/2013 10:23 professional development for school teachers, and writing for a nontechnical audience. Members receive a discount of up to 75% on the cost of Society training courses. The Society is also planning to hold courses outside London. For more information about our training events see www.societyofbiology. org/events If you have ideas for new courses, speakers or course providers please email our training officer at emmakelson@ societyofbiology.org to read and 87% think the design is good or excellent. Readers have also responded positively to our move up to six issues a year – 85% said the frequency is now about right. When asked what they liked least about the magazine, the top answer was ‘no dislikes’. Second after that were requests for more articles on specific topics or fields. We’ll be looking closely at all your suggestions for how we can improve and what to cover. As always, if you have any suggestions or comments about the magazine, or wish to respond to individual articles, please email [email protected] or write to us at the address on page 2. Tom Ireland MSB, managing editor The Society’s honorary treasurer Pat Goodwin has presented evidence to the first session of a Government inquiry on antimicrobial resistance. The Society was asked to present a witness to give oral evidence at the House of Commons Science and Technology Committee’s inquiry in December, having responded to the committee’s initial consultation earlier in 2013. Science Gophers spread to WaleS Gopher Science Labs, the hands-on science events run by the Society for young children, is to be developed in Wales following a successful pilot in England. The project, developed in collaboration with the Biochemical Haymeadows inSociety, Romania,sees primary school children above, the visit focusa Gopher Science Lab ofhosted Barbaraby a local secondary school Knowles’ (below and their students. centre) work Study abroad! Ten £500 grants are available for student affiliate, AMSB and early career members to travel overseas. Get your applications to us by Monday 31st March www.societyofbiology.org/ travelgrant Vol 61 No 1 / the biologist / 5 SOCIETY NEWS INTERNATIONAL ACTIVITY/BRANCH DATABASE/John Leonard Cloudsley-Thompson/AGM 2014 Society heads abroad to spread the word OBITUARY Desert specialist Professor CloudsleyThompson, pictured in Sudan in 1964, became a prolific writer A ustralia, New Zealand, Hong Kong and Mongolia are all in our sights this year as the Society expands its international presence outside Europe. A number of members from Australia and New Zealand have expressed an interest in forming an international branch of the Society that would help coordinate activities and communicate our work in the region. The Society is asking that any more overseas members who are interested should contact our membership team with their suggestions. In March Society staff will travel to Hong Kong to run workshops and meet members at the Science Alive festival. Organised by the British Council and held at Hong Kong Science Museum, the event invites leading UK academics and communicators to engage students, teachers and the public in activities that promote a wider understanding of science. Also that month the Society’s chief executive, Dr Mark Downs, will be travelling to Vancouver in Canada to speak at the College of Applied Biology’s AGM. The Society will also continue to help address conservation issues in Mongolia after Dr Downs’ trip to the country last year, where he met their minister for the environment who BRANCH OUT! T he Society is calling for members to let us know their local branch affiliation and update their contact details to ensure they receive the latest on news, activities and events taking place in their area. All members have the opportunity 6 / the biologist / Vol 61 No 1 Venue: Hong Kong Science Museum, and wolf cubs in Mongolia, below Any more interested overseas members should get in touch Make the most of membership by updating your details agreed to ban the use of live wolf cubs as part of traditional hunting festivals. Last year the Society signed an agreement with south-east Asian life sciences association BioSingapore, again bolstering ties with the region. If any overseas members are interested in helping to promote the work of the Society in their region please contact [email protected] to be associated on our database with one of the Society’s 16 regional branches in the UK, and be directly informed about local branch events and activities. Members can check their details online via our secure mySociety portal (mysociety. societyofbiology. org) and ensure that Professor John Leonard CloudsleyThompson FSB 1921-2013 T he Times described John as an “adventurous and welltravelled zoologist” and “a natural historian of the old school”. AGM 2014: Save the date their email address and branch connection is current. It is important that we have up-to-date information about our members so that the full breadth of expertise and knowledge that exists within our membership is fully recognised and used. Please therefore take the time to fill in your profile with as much information as you can and get in touch with markleach@ societyofbiology.org if you have any queries. www.societyofbiology.org/news He made his name as a desert specialist in the 1960s at the University of Khartoum and as keeper of the Sudan Natural History Museum, which he supported with little funding. Typically seen in khaki shirt and trousers negotiating desert tracks in a jeep, John was known for getting on with his research or writing even during sweltering heat. Born in Murree in India (now part of Pakistan), John was educated at Marlborough College and his studies at Cambridge were interrupted by the war. During his service in North Africa he collected camel spiders and scorpions and tamed a desert fox to barter for food, sparking his life-long interest in desert animals. When his tank was attacked, in 1942, he sustained a leg injury that would trouble him for life but back in England persuaded a medical board to let him join the Normandy landings. Nature published his observations on the common centipede in 1945 and he began to write for the journal of the British Naturalists’ Association. By 1950 he was lecturer in zoology at King’s College London. In 1972, after a decade in Sudan, he became professor of zoology at Birkbeck College, London (emeritus 1986). His 50 books and many papers included work on bees, sea lions and wasps, Sahara and Mesozoic reptiles and a war memoir, Sharpshooter. He published dozens of books and papers on his observations and wrote many letters on international development budgets. John was also chairman and vice president of the British Naturalists’ Association and president of the British Arachnological Society, the British Society for Chronobiology and the British Herpetological Society. A special book devoted to scorpions was produced to mark his 90th birthday. He is survived by three sons. T he Society of Biology’s AGM will take place at Charles Darwin House, London, on Thursday 15th May 2014. Refreshments will be available from 11:00. The AGM will start at 11:30 with the charter lecture at 12:45. Members from all grades are welcome to attend but only those at member grade MSB and above are entitled to vote. Up to two representatives from each Member Organisation of the Society can attend the AGM but just one can www.societyofbiology.org/news vote, and supporting Member Organisations may not vote. Information on voting and current Council vacancies has been circulated to all members and Member Organisations. It is also available online and by contacting [email protected] To attend, please register via mySociety (mysociety. societyofbiology.org) or write to Natasha Neill at the address found on page 2. www.societyofbiology.org/agm Vol 61 No 1 / the biologist / 7 Opinion per year in restored biomes, provided we also curb current forest destruction. Agricultural land is useless as a carbon store but our remaining natural land biomes store about 2.5GTC per year. Restoring one third of the existing world farmland to fully functioning forest or wetland would meet the gap. Farming is often efficient, but food waste, because of commercial interests, is high. Its elimination, and a healthy change in diet, could compensate for the renovation of farmland to functioning biome. It’s not impossible, but our political leadership is poorly educated for the job (only one of 194 world leaders has any background in environmental issues; 75% come from finance, business, economics, politics, law, the military or hard engineering (Moss, 2012)). In England, at least, our state conservation organisation, Natural England (NE), is no longer led by ecologists, and appears to be dominated operationally by A revolution is our only hope Current conservation orthodoxies do little to protect the Earth, says Professor Brian Moss L iving in Europe has cultural pleasures, but natural limitations. Our continent is so dominated by people that our concepts of how our planet functions are seriously biased. We live in a land where the former connectedness of all natural systems has largely been obliterated. This blinds our ability to plan for the future and we promote mediocrity in our landscapes through our conservation legislation. Starting with the National Parks and Access to the Countryside Act of 1949 and continuing with the 8 / the biologist / Vol 61 No 1 EU Habitats Directive of 1992, we seek in the UK mostly to preserve postage stamps of traditional grassland agriculture. Instead we should be thinking of a future beset by climate change, where if we start re-establishing forest and wetland systems for carbon storage and water conservation, things may be a little less uncomfortable. We need to think in terms of ecosystem function first and individual species conservation second. Carbon sinks such as forests are key to our future. The UK may be small but we are influential in world politics and need to show Brian Moss is emeritus professor at the University of Liverpool’s School of Environmental Sciences. He works on lakes and climate change, and has published several books on ecology. agricultural land managers, whose natural instincts are to emphasise the conservation of artificial grassland through stock grazing. One example is NE’s support for the English Lake District to be designated a World Heritage Site as a cultural agricultural set of landscapes in their present depauperate state (Monbiot, 2013), which would fix its bleak and bare fells for the foreseeable future. Others concern policies for maintaining its own national and local nature reserves. I live close to the Ainsdale Sand Dunes National Nature Reserve, which for 20 years has been fenced to graze sheep in winter in an attempt to prevent natural succession to woodland. Inspection of NE’s monitoring data shows that the sheep have had no effect; statistical analysis of data from enclosures on the reserve draws the conclusion that rabbits alone explain the grazing effects (Millett & Edmondson, 2013). Nonetheless, References Le Quéré, C. et al. The global carbon budget 1959–2011. Earth System Science Data 5, 1107–1157 (2012). Millett, J. & Edmondson, S. The impact of 36 years of grazing management on vegetation dynamics in dune slacks. Jnl. of Applied Ecology 50, 1367-1376. (2013). Monbiot, G. The Lake District is a wildlife desert. Blame Wordsworth. The Guardian, 2 September 2013. Moss, B. Liberation Ecology: The Reconciliation of Natural and Human Cultures (International Ecology Institute, Excellence in Ecology Series, Germany, 2012). The Lake District – “an area of bleak and bare fells in a depauperate state” – according to Moss a Higher Level Stewardship agreement for the adjacent local nature reserve is proposing to fence this in too, though encouragement of the rabbit population would avoid an enclosure of the landscape that local people abhor. The worst aspect of the issue, however, is Natural England’s insistence that all this is necessary to tick the box of a Habitats Directive requirement to maintain solely open grassland on fixed dunes, when we need more forest and we can have forest here for free. This would happen if the owners and the local authority, with the peculiar collusion of the Forestry Commission, were to stop cutting it, reverting it to a scrub so disturbed as never to acquire much diversity or carbon storage. We need independent, powerful conservation organisations that are infused by radical new thinking. We need a regenerated conservation movement to look at our planetary requirements for the future. We also need to question thinking that might have been appropriate half a century ago, and may currently be shrouded in well-meaning legislation, but is now outdated and needs revision. a willingness to do what we assert that the rest of the world should be doing, in preserving natural biomes. Each year now, the world’s population releases about 9.3 gigatonnes of carbon (GTC) into the atmosphere – 8.3GTC from fossil fuel burning, and 1.0GTC from destruction of forests. Around 2.5GTC are taken up in the ocean and 2.5GTC by the remaining land biomes (Le Quéré et al, 2012). This leaves a surplus of 4.3GTC that accumulates in the atmosphere and which we need to remove in order to check global warming. Temperatures will not fall until storages are greater than emissions. We have made no net progress in reducing emissions and little in developing alternative energy sources. There is much debate about geoengineering to mitigate climate change, using techniques that are yet to be invented or with unknown risks, yet we ignore the natural storages that have been tested over half a billion years. We could store as much as 3GTC Vol 61 No 1 / the biologist / 9 HEARTLAND ARTS/SHUTTERSTOCK Policy update A healthy dose of nature DIRIMA/SHUTTERSTOCK The Scottish Government has recognised the benefits of green space in places such as Glasgow The relationship between nature and good health is complex but medical professionals and ecologists are starting to find a common language I f you are male and born in Lenzie, a small Scottish commuter town with tree lined streets, surrounded by fields, statistically you can expect to live to 821 – 28 years longer than a male born in Glasgow’s densely populated inner city district of Calton, just 13km away. Male life expectancy in Calton is a mere 54 years2 and the number of trees in the neighbourhood cannot entirely explain this inequality. Health is the outcome of a complex interaction between individual characteristics and external factors; and social, environmental and health inequalities often go hand in hand3. But this example does show that the natural world does more than just 10 / the biologist / Vol 61 No 1 ensure our basic survival by providing clean air and water and raw materials for agriculture and industry. Ecosystems contribute in three ways to our health and wellbeing4. They have direct positive effects on both mental and physical health. They also have indirect positive effects, through providing a space for nature-based activity and social engagement, and facilitating behavioural change with people adopting healthier lifestyles. Ecosystems also protect us from threats from pollution and disease vectors through functions such as local climate regulation, noise reduction and the removal of pollutants in water and air. Daija Angeli, project officer, Natural Capital Initiative. It’s one thing to say that nature is good for you – the Victorians knew that when they created public parks and walks to improve conditions in the newly industrialised urban areas of cities like London, Manchester and Birmingham. It is another thing to establish robust evidence of the benefits generated by different ecosystems to inform policy. Yet our understanding of how high quality environments have the potential to nurture our health has improved greatly in recent years. Research shows that observing nature and ‘green exercise’ – physical activity in the presence of nature – positively influence our health. Clear links have been established between the amount of accessible green space and psychological wellbeing. There is even evidence of indirect effects such as how green spaces help to bring people together and strengthen neighbourhood ties; this ‘social capital’ then has positive effects on health. www.societyofbiology.org/policy However, health outcomes do not only depend on the types of ecosystems and the services they provide but also on the choices people have and decisions they make. So only if you choose to go bird watching in your free time, or take a brisk walk in your local park, for example, can you derive the mental or physical health benefits the natural environment provides. The choice to engage with nature is influenced by various factors and access to nature very much depends on socioeconomic characteristics. The UK Natural Ecosystem Assessment5 summarises that “health benefits are, therefore, a function of ecosystem type, ease of access to nature and frequency of use of green places”. While there is a growing body of research, establishing evidence around ecosystems and health isn’t straightforward. In many cases the cause and effect relationships are not definitive. For example, do green spaces prompt people to be active or do people who like to exercise move to areas with easy access to nature? In addition, the collaboration between healthcare professionals and ecologists brings a set of challenges. To shed light on these challenges, the Natural Capital Initiative, the special interest group of the Society that supports decision-making for the sustainable management of our natural capital, held a session on health at INTECOL 20136, a major international ecological congress. The session revealed that there is a huge disconnect between the disciplines despite working on similar topics. This is partly because the medical community and ecologists differ in what they regard as evidence. Medical professionals rely on clinical understanding the environment ■ Ecosystem Services are defined as the benefits obtained from an ecosystem. These can be services that provide goods and products like food, fuel and water, regulating services such as flood control, supporting services such as nutrient cycling, or cultural services that provide recreational and spiritual benefits to people. www.societyofbiology.org/policy ■ Natural Capital is the stock and flows of a natural system. It is commonly used as one way to describe the economic value of nature. ■ The UK National Ecosystem Assessment is an overview of the natural environment in the UK and its value to society and the economy. The first assessment was published in 2011 and it is now in its second phase. trials and systematic reviews, while ecologists use field based techniques and empirical studies. A resulting lack of common language is a barrier to collaboration. Despite these challenges and gaps in the evidence base, public policy has recently rediscovered the importance of ecosystems for good health. To tackle the stark health inequalities in Scotland, the Scottish Government’s Good Places, Better Health7 initiative looked to shape places that nurture health and wellbeing, with a prototype focusing on health challenges faced by children in Scotland. Public Health England launched the Healthy People, Healthy Places programme in November last year to support a place-based approach to health and the Environment Strategy for Wales8 links to the public health agenda and other cross cutting issues in Wales. In addition, the recent shift of responsibility for public health from the NHS to local authorities also brings the chance for new ways of collaboration with spatial planners, guided by the research of ecologists and health professionals. There is still a long way to go before our environmental and well-being policies are truly aligned, but these developments are a welcome demonstration that governments are beginning to value our natural capital for all that it is worth. references 1-2 WHO (World Health Organization). Closing the gap in a generation: Health equity through action on the social determinants of health (2008). Available at: http://www.who.int/ social_determinants/ thecommission/ finalreport/en/index. html 3 Barton, H. and Grant, M. A health map for the local human habitat. Journal of the Royal Society for the Promotion of Public Health, 126(6) 252-261 (2006). 4 Maantay, J. A. The Collapse of Place: Derelict Land, Deprivation, and Health Inequality in Glasgow, Scotland. Cities and the Environment (CATE): 6(1), Article 10 (2013). Available at: http:// digitalcommons.lmu. edu/cate/vol6/iss1/10 5 UK National Ecosystem Assessment. The UK National Ecosystem Assessment Technical Report. UNEP-WCMC, Cambridge (2011). 6 Natural Capital Initiative. Workshop on natural capital and barriers to evidencing impacts on human health, Summary Report (2013). Available at: http://www. naturalcapitalinitiative. org.uk/past-events 7 Scottish Government. Good Places, Better Health (2008). Available at: www. scotland.gov. uk/Resource/ Doc/254447/0075343. pdf 8 Welsh Assembly Government. Environment Strategy for Wales (2006). Available at: www.wlga. gov.uk/download. php?id=3972&l=1 Vol 61 No 1 / the biologist / 11 microbiology GUT MICROBIOTA I t is widely known that humans do not exist as single organisms. In fact, we go to bed each night with 100 trillion microbes tucked up cosily inside our intestines. What we are now beginning to discover is just how important these tiny organisms are in stimulating, training and regulating our own bodies. The gut microbiota is a diverse community of microbes comprising mainly of bacteria but also some species of archaea and fungi. At least 90% of the bacteria in our digestive tract fall into the phyla Bacteroidetes and Firmicutes1, yet species diversity is astounding. Estimates suggest there could be between 500 and 1,000 species within the whole human population2. In its combined genome, the microbiome contains more than 5 million genes3, putting the human genome to shame at just 24,000. This cooperative community performs many functions, including its primary role to ferment otherwise indigestible carbohydrates, extracting energy. It also helps to absorb nutrients and produce vitamins as well as training and regulating our immune systems. In fact, it is so useful that the microbiota is often considered an organ in itself. T G U FE L NG E I BIOgraphy Lauren Hoskin explores our ever-increasing understanding of how bacteria contribute to our health 12 / the biologist / Vol 61 No 1 Lauren Hoskin AMSB is a microbiology graduate currently studying for a master’s in science communication at Imperial College London. She writes for the blog Science Says as well as the Society’s blog. Bacterial birth Since unborn children are sterile, birth is the first step in the lifelong companionship between human and microbe. How the baby is delivered is important. Many studies have shown that children born by Caesarean section start life with a smaller and less diverse microbial community. It has also been shown that while vaginallydelivered infants harbour bacterial communities similar to their mother’s vaginal microbiota, infants delivered by Caesarean tend to adopt communities similar to their mother’s skin surface4. One study demonstrated that the microbiota of a Caesarean-delivered infant includes fewer Bacteroidetes, one of the two major phyla in the gut. The study was also interested in the infants’ immune systems, and so tested for the abundance of a certain type of white blood cells called Th1 cells. These cells release signalling molecules to regulate other white blood cells as part of the body’s immune response, and children delivered by Caesarean were found to have decreased levels of Th1 activity5. These results are significant in our understanding of microbial activity since they suggest that gutspecific bacteria play an important role in immune development, and in particular Th1 development. Th1 activity is vital for many immunological processes including the stimulation of antibodies, release of signalling molecules and the killing and digesting of pathogenic bacteria. It is also crucial in dampening the activity of its colleague, Th2. As a result, decreased Th1 activity can lead to Th2 over-activity. Th2 overactivity is thought to be one of the major causes of allergic disease development. This includes hay fever, asthma and eczema. These results are corroborated by findings that children born by Caesarean section have a higher rate of allergy6. Under attack Another line of research has investigated whether the administration of antibiotics to infants may have the same effect. It is thought that while the microbiota is in the early stages of development, it is more susceptible to damage from the effects of antibiotics. Since many antibiotics kill bacteria in an unspecific manner, by taking these drugs Vol 61 No 1 / the biologist / 13 we are unintentionally eradicating many of our ‘friendly’ microbes. A compromised microbiota could subsequently lead to Th2 overactivity and, in turn, the development of an allergic disease later in life. A number of studies have shown a positive correlation between antibiotic use in infancy and the successive development of allergic disease7. Intense use of antibiotics is also well known to alter microbial composition to the point of causing antibiotic-associated diarrhoea. In extreme cases, the microbe Clostridium difficile is allowed to thrive – where normally the microbiota repress its growth – often with deadly consequences. Foraging for carbohydrates Immune development is, of course, not the microbiota’s only job. As well as training our immune system to defend itself, these obliging microbes also help us to digest much of our food. The fluid within many bacterial cells contains numerous carbohydrate-digesting enzymes, which we ourselves do not possess. Like ruminants, humans are dependent on the microbiota to supply many of our nutrients, especially those from non-digestible carbohydrates. One study has demonstrated that germ-free rodents, raised in a microbe-free environment, require 30% more calories to maintain their body mass than normal mice8. Some of our friendly microbes boast the ability to modify their carbohydrate-foraging behaviour to suit availability. In times of plenty, Bacteroides thetaiotaomicron metabolises dietary sugars found in the intestines. When nutrition is scarce, however, its gene expression changes and it begins to digest sugars within the host’s own mucus. Through many of these mechanisms, the human body has become heavily reliant on the microbiota, as has the microbiota on the human. We have, it seems, evolved together over many millennia and will continue to do so as the world around us changes. As a result, the microbiota is greatly affected by the food we eat. Past studies have shown that nutritional differences can have huge impacts on the microbiota. Likewise, the composition of the 14 / the biologist / Vol 61 No 1 microbiota also impacts on the digestion of our food. One study investigated the microbiota of children from a rural village in Burkina Faso and discovered that it contained an exceptional abundance of the bacteria Prevotella9, which the European children lacked. Prevotella was shown to be particularly competent at digesting cellulose, which suggests that the microbiota of this community has co-evolved with their diet, which is rich in plant fibres. Microbiota and obesity Recent research revealed a substantial difference between the gut microbiota of twins when one was obese and the other slim10. When these twins’ faecal microbiota was extracted and transplanted into germ-free mice, the mice were shown to develop the body composition of their human counterparts, with a high increase in body mass and adiposity. In essence, the mice with the microbes from the obese twin became obese too. Furthermore, when the obese mice were cohoused with the lean mice, they eventually established a lean-like microbiota and were prevented from developing obesity. This coincided with the transmission of bacteria of the order Bacteroidales, which includes the species Prevotella, from the lean to the obese mice. However, this change only occurred in mice that were on a diet representative of a healthy human one – rich in fruit and vegetables and low in saturated fats – demonstrating that body mass cannot be altered simply by a microbiota transplant. This research is an important landmark since it suggests that the diet and microbiota are in constant communication and that interactions between the two can greatly alter the host body. It indicates that the gut microbiota could be an important contributor to diseases such as obesity. In the future, mice could prove a useful tool for screening the impact of different nutrients on both the gut microbiota and the development of obesity. From immune system development and regulation to enzyme production, the microbiota is an amazing part of the human body. Without these friendly microbes we could not be the creatures we are today. The microbiota of children in Burkina Faso is rich in the cellulosedigesting Prevotella There are around 10 trillion bacterial cells living in and on a human body The average human body houses 10x more bacterial cells than human cells Research has linked variations in gut bacteria with obesity Do you have an opinion on this article? Contact us AT [email protected] The combined genome of the microbiome could contain up to 5 million genes, compared to 24,000 in humans References 1 Robles Alonso, V. & Guarner, F. Linking the gut microbiota to human health. British Jnl. of Nutrition 109, S21-S26 (2013). 2 Sears, C. L. A dynamic partnership: Celebrating our gut flora. Anaerobe 11, 247-51 (2005). 3 Sommer, F. & Baeckhed, F. The gut microbiota - masters of host development and physiology. Nature Reviews Microbiology 11, 227-38 (2013). 4 Dominguez-Bello, M. G. et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences of the United States of America 107, 11971-75 (2010). 5 Jakobsson, H. E. et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section. Gut (online) (2013). 6 Kero, J. et al. Mode of delivery and asthma Is there a connection? Pediatric Research 52, 6-11 (2002). 7 Droste, J. H. et al. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clinical & Experimental Allergy 30, 1547-53 (2000). 8 Wostmann, B. S. et al. Dietary-intake, energy-metabolism, and excretory losses of adult male germfree wistar rats. Laboratory Animal Science 33, 46-50 (1983). 9 De Filippo, C. et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America 107, 14691-96 (2010). 10 Ridaura, V. K. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341 (6150), 1241214 (2013). Mice have been used to demonstrate how microbiota ‘transplants’ can affect weight gain Vol 61 No 1 / the biologist / 15 ANYAIVANOVA/HECTOR CONESA/ZURIJETA/SHUTTERSTOCK microbiology GUT MICROBIOTA FORESTRY URBAN TREES T Trees make a valuable environmental contribution to inner city areas, such as the Heygate estate in south London he broad bean has a lot to answer for. Thanks to that primary school experiment with a jam jar and blotting paper, the idea that all roots grow vertically downwards is firmly embedded in the national psyche. Unfortunately this is not helpful when it comes to the care and protection of big trees in towns and cities. Even the most majestic of specimens has a root system that grows horizontally through the uppermost half metre of the ground. The roots generally extend far beyond the tips of the branches and their shallowness makes them vulnerable. Trees and their green infrastructure can provide significant environmental benefits in towns and cities. The capacity of the leaf canopy – to filter pollution, lower air temperatures, intercept rainfall and offer shade and shelter – is now highly valued by more enlightened city planners. Healthcare professionals are also beginning to recognise the positive role that accessible green space can play in improving human health and wellbeing (for more see page 10). All these benefits are greatest where the urban landscape contains large trees. This is reflected in the enhanced property value in the leafiest neighbourhoods. In the case of London, and most other long established cities around the world, the legacy of big trees has its origins in the visionary plantings of more than a century ago. In the 1800s industrial entrepreneurs and public benefactors pioneered Britain’s urban parks movement and property speculators planted tree lined avenues. While the decision to plant large-growing trees such as limes, chestnuts and planes may have been well planned and executed, their long term success has usually been achieved by chance. London’s street trees were mostly planted in the era of horse-drawn transport, when the ground below was almost entirely free of pipes and cables, and the roots were able to grow wherever conditions suited them. The free passage of air and water was originally relatively unrestricted, and those long established trees have continued to survive by exploiting weaknesses such as fractured drains and cracked pavements. But as water companies replace old jointed supply pipes, they are inadvertently depriving the mature urban forest of its unofficial underground irrigation system. Many of London’s famous plane trees have the capacity to live for another century or more. However, where major disruption is planned through redevelopment and physical reconstruction, retaining and protecting the mature tree heritage becomes extremely challenging. It is impossible to assess the precise root pattern of mature trees from observation above the ground. The roots ORLA/SHUTTERSTOCK THE ROOT OF THE PROBLEM Working round the sprawling feeding system of precious city trees can be a crucial part of urban regeneration projects, writes Chris Baines 16 / the biologist / Vol 61 No 1 Vol 61 No 1 / the biologist / 17 FORESTRY URBAN TREES remove the ground while causing very little physical damage to the roots themselves. In this way it is possible to excavate a service trench through the root zone while allowing the living roots to bridge the trench for the duration of the installation. Provided the roots are kept moist by spraying with water or wrapping with wet hessian, then the trench can be backfilled following construction with very little lasting harm to the tree. Remote-guided trenchless tunnelling is another useful technique. It is widely used for the renewal of gas and water pipes, and the technology makes it possible to bore new service lines through clays, sands, gravels and filled sites to a depth of 1.5m. Trenchless technology ROOT MAPPING 1 Radar equipment can be used to detect what is underground BIOgraphy Chris Baines FSB is an environmentalist and adviser to government and water, financial management and urban regeneration companies. He is a vice president of the Royal Society of Wildlife Trusts and president of the AECB sustainable building association. has also been used to install services beneath the foundations of historic buildings and is particularly useful for tunnelling through vulnerable landscapes. The same technology lends itself to tunnelling under the root network of tree-heavy urban redevelopment sites. Since renewal of drains and water pipe systems poses a threat to the unofficial water supply of established roots, it is vital to make provision for maintaining optimum soil moisture. Good drainage is important, and the design of paved surfaces should allow for the free passage of rainwater through the underlying root zone. Mature tree cover has an important role to play in intercepting heavy rainfall and reducing the risk of flash flooding. The tree root zone can also serve as a natural reservoir for temporarily retaining surplus rainwater. There is a range of commercial products available which provide structural strength beneath the ground while allowing an open soil structure with enhanced water-holding capacity. Protecting large and precious trees as cities grow creates considerable challenges. But there is a determination across many groups – developers, academic researchers, utilities providers, councils and other non-profit organisations – to use regeneration projects, such as on the Heygate estate (see case study below) as an opportunity to improve our understanding of big trees in the inner city. CASE STUDY 2 Compressed air at twice the speed of sound loosens and removes ground material 3 tend to grow into those areas of substrate where conditions are most suitable. They naturally seek out root-penetrable mineral material, optimum moisture and oxygen, and they grow best where there is an absence of toxic contamination. This means that the root pattern of an urban forest tree is very unlikely to be radially symmetrical. However, new technologies make it possible to map the upper layer of a development site ahead of any physical disturbance. Ground penetrating radar, originally developed for military use in locating buried explosives, is now widely used in the construction industry to find underground services such as cables and pipes, 18 / the biologist / Vol 61 No 1 A trench excavated using an air-spade has left the tree roots intact as well as for archaeological functions. A skilled operator can use this technology to locate tree roots in the upper 2m of ground, both laterally and vertically. The resulting 3D image of the subterranean site can then be used in planning the route of proposed services, determining the site for the foundations for new buildings and for other elements of excavation and construction. Understanding in advance the existing root pattern enables service engineers and utility companies to sympathetically plan the service layout. However, in an established landscape that is heavily planted, there will be few areas of existing Accessible green space can improve human health and wellbeing open space that are root free. For the introduction of very large structures, such as major sewerage pipes or district heating pipes, there may be no alternative but to sacrifice some trees in order to create a pathway for wide and deep open trenching. Fortunately, in many cases the subsurface site plan will reveal obvious preferred routes for such major disturbance. It is now possible to install and maintain small-scale utilities such as gas and water pipes, and underground power and telecommunication cables, beneath the shallow root plate. An air-spade is a tool which uses a narrow jet of compressed air blowing at twice the speed of sound to loosen and Demolition and redevelopment of the Heygate estate in London’s Elephant and Castle district T he Heygate is a high-rise housing neighbourhood of more than 2,000 empty flats in south London due for demolition and redevelopment. The 1970s tower blocks are set in a mature but neglected landscape containing more than 450 very large trees. Most of them are London planes (Platanus x acerifolia) and many are more than five storeys tall. The positive environmental contribution that they make to this part of the inner city is extraordinary, and the trees are highly valued by many of the local people. The Australian developer Lend Lease has acknowledged that the trees are valuable growing assets which need protecting. Exploratory air-spade excavation of a typical part of the site has confirmed that most tree roots are growing within the upper 500mm of the ground. The substrate for much of the site is brick and concrete rubble from demolished The 1970s tower blocks are set among 450 large trees, some more than five storeys tall Do you have an opinion on this article? Contact us AT [email protected] 19th century buildings. This relatively loose and nutrient-poor mixture of crushed aggregates forms an extremely free-draining layer over relatively impervious London clay, and this has created ideal rooting conditions. London plane is a hybrid between Platanus orientalis and Platanus occidentalis and in the wild both these parent species are natural colonisers of river gravels. As a consequence, the London planes on the Heygate estate and in many other parts of post-war London have produced very large specimens with very stable and wide-spreading root systems. The developer spent two years assessing the established trees and adjusting the proposed layout on the estate footprint before demolition to allow the most significant of them more space. The senior design team and key consultants have also been involved in a number of site visits and treeprotection seminars, with their appreciation of the mature trees greatly improved as a result. The Heygate estate is one of a small number of urban developments in the Clinton Climate Initiative and Lend Lease is now working in partnership with academic research bodies, major utility providers such as Thames Water, and special interest groups within the not-for-profit sector to encourage research and technical innovation throughout the period of reconstruction and beyond. Vol 61 No 1 / the biologist / 19 DEBATE ALGAL BIOFUELS C Algal biofuel in bloom or dead in the water? Tom Ireland reports from the Society’s recent debate on whether fuel made from algae could ever replace oil 20 / the biologist / Vol 61 No 1 ould algae save the planet? That’s right, algae. The green stuff that clogs up your pond and rots in giant heaps on the beach giving off a terrible pong. This extremely diverse group of simple, autotrophic organisms is the focus of efforts to develop a green energy source to replace oil. Both microalgae (unicellular) and macroalgae, such as seaweed, are being used in a range of products known as ‘advanced biofuels’ thanks to their rich energy content and minimal land use. It is hoped they could eventually break our dependence on oil and reduce global carbon emissions. As part of the Society of Biology’s Policy Lates debate series, experts from the world of biofuels gathered in London to discuss the future of this remarkable group of organisms in energy production. Is fuel derived from algae a viable alternative to oil, or just a green dream? Turning water into fuel Algae are like any other photoautotrophic organism: they turn simple inorganic compounds such as CO2 and water into complex, energy rich hydrocarbons using light as an energy source. The technology and infrastructure to create fuel from this sort of biomass have existed for at least 60 years. Dry plant matter (lignocellulose) is the most abundant raw material in the world for the production of ethanol by fermentation, and many biofuels are made using the oils from crops such as corn or soya beans. Yet the displacement effect of using land crops for fuel production instead of food arguably causes more carbon emissions via deforestation and can drive up food prices. Oliver Chadwick, from the Department for Transport, says some models suggest that in terms of 8km To provide biofuel for one lane of cars requires a strip of land the length of that lane, 8km wide emissions it can actually be worse than using crude oil. “To provide biofuel for one lane of cars requires a strip of land the length of that lane, and 8km wide,” he says. “Conventional biomass is just not efficient in terms of land use.” This is where algae come in. Some species of microalgae can convert up to 60% of their biomass to oils (compared to 2-3% in soy beans). Because they do not produce complex differentiated tissues such as stems and leaves, algae grow faster than crops. Plus, marine macroalgae do not even have to be grown on land. “You can do much better than terrestrial plants using algae,” says Professor Rod Scott from the University of Bath. His research aims to develop strains of microalgae especially for biofuel production. “To provide 50% of the USA’s fuel requirements with corn oil, you’d need 846% of the available crop area in the How does it work? Algae can be turned into fuel via: Anaerobic digestion by bacteria, producing methane. Transesterification, where algal lipids are reacted with alcohols to produce biodiesel and glycerol. Pyrolysis and hydrothermal liquefaction, which use heat and pressure to reduce algal lipids to a range of fuel products. The advantage of the latter is that whole algae or ‘wet biomass’ can be used. US, which is clearly impossible. That falls to just 2.5% with microalgae.” Mixing algal biomass with a solvent and catalyst produces a diesel-like substance called biodiesel, plus glycerol. Techniques are emerging which mean products are not limited to biodiesel. Pyrolysis involves heating algae to very high temperatures (500-700°C) in the absence of oxygen to produce a biochar (charcoal) and a wider range of fuel products. Hydrothermal liquefaction puts whole, unprocessed algal material under pressure, using slightly lower high temperatures (250-350°C), with water to produce ‘biocrude’ and hydrogen gas. These processes essentially mimic the natural production of oil. Crude oil itself is formed from ancient algae, as well as other marine plankton. Algaenan, a tough hydrocarbon polymer found in algal cell walls, is turned to oil when layers of plankton are buried under the seabed and subjected to extreme heat and pressure. Unfortunately, producing oil this way takes about 30 million years. Replicating the process in real time, at a scale vast enough to supply global demand, is the challenge. All in a day Professor Scott says processes such as pyrolysis can produce an oil equivalent from algae in about a day. But it is important to see “just how much oil we use” before getting excited about algal fuels, he says. “At the moment we use 90 million barrels of oil, over 14 billion litres – every single day. You can fiddle around with a flask of new fuel and think we’re doing quite a good job, but we use a staggering amount of oil.” There are great costs involved in growing and processing algae compared to just piping stuff out of the ground. Algal cells produce more Vol 61 No 1 / the biologist / 21 DEBATE ALGAL BIOFUELS biofuel it must show its green credentials, says Dr Michele Stanley, director of the NERC Algal Bioenergy Special Interest Group. “Seaweed beds on the ocean floor have an important role in preventing coastal erosion, and removing beached kelp interferes with coastal ecosystems,” she says, “so you can’t just come along and take it all away.” China is well ahead when it comes to growing seaweed in shallow waters, producing an estimated 10 million tonnes a year. Elsewhere, production is still low, says Dr Stanley. “It all falls to pieces when it comes to economics,” she says. “Costs can vary from €50 per tonne for nearshore, floating kelp, to €400 for offshore kelp, to €2,500-plus for experimental systems.” global institute of sustainability, colorado state university, sapphire energy, pacific northwest national laboratory Algal farming for biofuels, today (this picture and below) and in the future (images right) hydrocarbons when they are starved of nitrogen, so it is a two-step process, where the cells that are to be starved must be separated from the ones still growing. Also, the more microalgae you try to grow in one space, the less light gets through to each cell, meaning growth rate falls. Dr Andrew Spicer is chief research scientist of Algenuity, a UK company that provides products and services to the emerging algal biotech industry. He says microalgal biofuel production Stacking up? Oil vs Algae in numbers 22 / the biologist / Vol 61 No 1 will need to be scalable up to “millions of tonnes per year” if it is to replace liquid fuels in any meaningful way. Influential reports on biofuels1-2 say it is biology, not industry, that will help drive this through strain selection and optimisation. Yet Dr Spicer says significant challenges remain in translating bioengineering to the industrial agricultural scale necessary for industry. “To assume you can genetically modify an algal cell to produce more 14bn litres of oil used per day globally 1bn 1bn 1bn 1bn 1bn 1bn 1bn 1bn 1bn 1bn 1bn 1bn 1bn 1bn Is fuel derived from algae a viable alternative to oil, or just a green dream? 25% The amount of global carbon emissions accounted for by transport biofuel and then expect to grow it en masse is perhaps naïve,” says Dr Spicer. “It doesn’t adequately take into account the regulatory requirements and risk analyses that would need to be satisfied prior to any significant trials.” In the face of such challenges, Dr Spicer describes how many companies who initially branded themselves as algal biofuel companies have shifted toward the production of “higher value, lower volume algal products as opposed to fuels”. 98% Proportion of transport fuel produced from oil Macroalgae, such as seaweed, already grows in vast quantities and can be farmed from the sea, or recovered from the beach, so may seem like a more promising biofuel feedstock. They can also provide valuable environmental services. For example, seaweed can remove excess nitrogen from salmon farms, while some species of algae can contribute to waste water treatment, bioplastics, food, and protein production. Yet before anything can be called a 60% The biomass of certain algae, such as eustigmatophytes, that can be turned into lipid References 1 Lundquist, T. J. et al. A Realistic Technology and Engineering Assessment of Algae Biofuel Production. Energy Biosciences Institute (2010). http://works.bepress. com/tlundqui/5 2 Shirvani, T. et al. Life cycle energy and greenhouse gas analysis for algaederived biodiesel. Energy Environ. Sci. 4, 3773-3778 (2011). Part of the mix Ultimately, algae are likely to be a valuable part of a range of products gradually replacing oil, says Dr Stanley, not a miracle alternative. “I’m of the view that one fuel won’t solve the energy crisis. People are fixated by the idea that there is one fuel out there – and there won’t be. Microalgae will not fuel the UK because of the land mass required, but it could provide a valuable contribution and other services like removing excess nutrients from waste water.” It is up to governments around the world to keep supporting research and put the infrastructure in place to support the production and use of algae as fuel. The UK Government will soon be calling for evidence on advanced biofuels to inform its energy strategy, including the emerging algae technologies mentioned in this article. The EU is also considering changing European renewable energy targets to take into account land use consequences, which could lead to additional support or subtargets for algal biofuels in transport. But, for the time being, algal biotechnologists will continue to burn the midnight oil in the hope of making a viable biofuel for the future. 0.2% The forecasted amount of road fuel that will be produced by algae by 2020 Do you have an opinion on this article? Contact us AT [email protected] OUR PANEL T hanks to all the panellists who contributed to the Policy Lates debate in December. For more information on the series contact [email protected] ■ Dr Michele Stanley FSB (chair) is director of the NERC Algal Bioenergy Special Interest Group and principal investigator in microalgal molecular phycology at the Scottish Association for Marine Science (SAMS). ■ Oliver Chadwick is the head of biofuels regulation at the Low Carbon Fuels department of the Department for Transport. ■ Duncan Eggar is the BBSRC’s Bioenergy Champion. ■ Rod Scott is a professor of plant molecular biology at the University of Bath. ■ Dr Andrew Spicer is the chief research scientist of Algenuity. 50 metres The length to which brown algae, such as giant kelp (Macrocystis pyrifera), can grow Vol 61 No 1 / the biologist / 23 EXPERIENCE CENTRIFUGE AT FARNBOROUGH The QinetiQ centrifuge will allow Sue Nelson (right) to get a taste of the G-Force effects felt by jet pilots Force of nature The Biologist editor Sue Nelson takes a spin in a centrifuge to experience the effects of G-force on the human body SHUTTERSTOCK/Oleksandr Koretskyi B 24 / the biologist / Vol 61 No 1 lame it on a love of science – or a love of both Star Trek and Star Wars – but I’ve always wanted to be an astronaut. So when someone offered to send me to Jupiter, I was more than ready. I was born ready. The interplanetary trip was in the form of the UK’s only human centrifuge at QinetiQ in Farnborough. The machine is a horizontal metal gantry, pivoted in the centre, housed in a large circular room. At one end is a capsule, or gondola, resembling a small cable car. By being strapped into a chair inside the gondola, and spun around at controlled speeds, my body can experience increasing amounts of G-forces for periods of 15 seconds at a time. On Earth, one G is the force of the Earth’s gravity. At 2.6G my body would feel more than double its weight. If I could walk on the surface of the largest planet in our solar system, this would be what it felt like. “At 2G you will experience some of the first physiological symptoms,” explains Dr Jon Scott, a senior scientist from QinetiQ’s Human Sciences Group. “As you get heavier your muscles get heavier, your bones get heavier and your blood also gets heavier. Heavier blood has a much harder job getting into your brain and your heart has to work harder to overcome this new weight. So the first thing that will happen is that less blood will start to travel into your brain and you will experience a strange change in your vision as the blood supply to your eyes starts to slow down.” The centrifuge at Farnborough is used to test jet pilots and teach physiology students The effects vary from less peripheral vision to a dimming of light across the whole visual field. A medical officer, Dr Simon Brown, will be monitoring my responses. “I’ll be in the centre of the centrifuge turning round like on a child’s roundabout,” he says. Physiologist Alex Stevenson harnesses me in and it’s a tight fit. There are windows at the sides but not ahead, only small cameras for monitoring test subjects, such as physiology students and jet pilots who use the facility for training and testing. “The major threat we have for fast jet pilots is something called G-LOC, which is G-induced loss of consciousness,” says Scott. “When they perform loop the loops and sharp turns, the G-forces force blood into their feet and we all know that we need blood supply into our brain to remain conscious.” Scott will watch me on a screen in the control room while Brown monitors me from the centre of the centrifuge and talks me through the experience. There is a loud metallic rumble. The gantry starts spinning and picks up speed surprisingly quickly. Within seconds the gondola rotates by 90˚ and I am Luke Skywalker in the cockpit of an X-Wing fighter. There is pressure on my cheeks, as if my face is stretching. Then my ears pop and my stomach lurches as if I’ve gone over the summit of a rollercoaster. A successful and enjoyable first spin. Vol 61 No 1 / the biologist / 25 EXPERIENCE CENTRIFUGE AT FARNBOROUGH 30G. “In 1955 we were at the dawn of the space age. But we were also trying to understand just how hard we could push our fast jet pilots. There may have been some thought of space at the time because it’s difficult to conceive that people thought fighter pilots would be pulling 30G in the future. Certainly some of the initial space rockets, the Saturn Vs, used to generate huge amounts of G because of the thrust involved.” The experience has given me a newfound respect for both astronauts and pilots. “It’s also crop sprayers,” adds Brown, “where they’re pulling up to 5, 6, 7G.” Military and aerobatic pilots can even train their bodies to withstand higher G-forces by tensing their muscles and training their breathing. With the current rise in the commercial spaceflight industry, a centrifuge can also give potential astronauts a taste of what it is like before going into space. “We know from the work that NASA Ames’ 5 degrees of freedom motion simulator became operational in 1961 we do here that centrifuges and G-forces can be quite stressful,” admits Scott. “They’re not necessarily for everybody. So the challenge for the industry is to try and identify who can and can’t fly, and come up with a set of standards that will allow the industry to flourish but simultaneously protect people who will be passengers.” Potential space passengers could then get a genuine experience of a spaceflight G-force profile before leaving the planet and spending hundreds of thousands of pounds on a ticket. “As big and scary as a centrifuge looks, it’s a very calm and controlled way to experience G-forces,” says Scott. “It is totally unique. It’s a unique piece of machinery and a unique branch of physiology which the average physiology or sports science student will not learn anything about in their degree.” For this would-be astronaut, it is also the ride of a lifetime. Centrifuges were used to train Russian cosmonauts, as commemorated by this 1981 stamp I readily agree to go up to 3G as Scott had mentioned that 2.6G is like being on Jupiter. It is the chance of a lifetime and I am not about to turn it down: “Take me to Jupiter.” This time Brown asks me to touch my nose mid-spin and it is as if there is an invisible weight on my arms. I manage to touch my nose but not without considerable effort. Afterwards I am slightly light headed, as if I’d stood up too quickly. It is still thrilling. “Would you like to up it to 3.4G?” Absolutely. This time is definitely not as pleasant. My hands are too heavy to lift from my lap. The skin on my face is being pulled harder. “We now know what you’re going to look like in 15 years,” laughs Brown. Between 3 and 4G is when most people start to experience some of the profound symptoms of increased acceleration. In jets these G-forces would be generated for a few seconds. In rockets, they are generated for minutes. Centrifuges were instrumental 26 / the biologist / Vol 61 No 1 in seeing what the human body could tolerate and scientists quickly discovered that people could not experience 5 or 6G for minutes on end, as they would lose consciousness. “One thing we learnt from centrifuges was that if you reorientate the person with respect to the G direction,” says Scott, “people can tolerate a lot more G.” In a fast jet, G-forces are experienced through the pilot’s head into their feet. But by reorientating a person so that G-forces go through their chest and out through their back, using a 90˚ rotation, the blood is not forced into their feet and the blood supply to the brain continues. As a result pilots can tolerate 10-15G without fainting. Yet it can still prove fatal. In 2011 a Red Arrows pilot died while performing aerobatics following a manoeuvre involving up to 6.3G. The effects of the G-forces were believed to be a factor in the accident. My hands are too heavy to lift from my lap. The skin on my face is being pulled “All we did with astronauts was reorientate them within the launch vehicles,” says Scott. “So for launch and re-entry, yes, they do experience significant G-forces, but the G is now acting in a different direction with respect to their body so they can tolerate them. It’s not pleasant but you stay conscious and they stay safe.” Afterwards, on the way to the control room, I receive feedback. “You adapted very well, and were comfortable enough to give a running commentary,” says Brown, “so I’d have earmarked you for up to a maximum for untrained volunteers, up to 5G. A star.” I am delighted. The control room is unexpectedly kitsch. QinetiQ also runs a centrifuge in Sweden, one of the most modern in the world. But the Farnborough centrifuge, completed in 1955, is pure Flash Gordon, with vintage dials, buttons and a manual G-force lever. In the 1950s Britain had – as now – a flourishing space programme. Scott points out a G meter in an adjoining room that goes up to a breathtaking NASA The Farnborough centrifuge, completed in 1955, is the only one in the UK Do you have an opinion on this article? Contact us AT [email protected] Vol 61 No 1 / the biologist / 27 INTERVIEW Professor DAME LINDA PARTRIDGE LIFE GOES ON Professor Dame Linda Partridge, an expert in ageing, talks to Tom Ireland about genetics, immortality and staying healthier for longer L inda Partridge is a British geneticist who studies the biology and genetics of ageing. Her research looks at how healthy lifespans can be extended in model organisms and the pharmacological treatments that could keep us in good health for longer as we age. From helping to equip the lab in her convent school, to discovering genes that influence ageing, Partridge’s long and successful contribution to science led to her being made a Dame Commander (DBE) in 2009. She is director of UCL’s Institute of Healthy Ageing and founding director of the Max Planck Institute for Biology of Ageing. THE ROYAL SOCIETY How did you come to work on lifespan and ageing? I was always interested in life histories – the costs of reproduction and how that can shorten life. As an evolutionary biologist, I was fascinated by those trade-offs. But what really led me to drop everything and focus on ageing mechanisms was the discovery of genes that could drastically alter the lifespan of organisms. It struck me as such a surprising result: that you could make one lesion in a gene and extend the life of an organism. That seemed to be a large flag waving in the wind to me. How well did your convent school prepare you for a career in science? The set-up was very well meaning – there was no hostility to science 28 / the biologist / Vol 61 No 1 or anything, and there was some equipment. But there were no technicians and if we were to maintain the biology materials in the time between when teachers came in to teach us those things, we had to do it ourselves. You discovered that there are universal genes found across different species which, when manipulated, can lead to increased lifespan. What do these genes normally do? These genes produce the proteins that make a signalling network, which senses the nutrient intake of the organism and some of the stresses that it experiences. The network tunes expression of genes so that costly processes such as growth, reproduction and metabolism are matched to nutritional status. If the organism is short of nutrients or starving, then it can go into a stress-resistant mode, where costly activities are reduced. My work owes much to a systematic search by a very clever scientist called Michael Klass. He was the first person to discover that mutation of certain genes could extend lifespan and slow ageing, working with nematode worms. In those days people were performing mutagenesis on worms (modifying their DNA), looking at how to change all kinds of traits – and Klass was looking specifically at how you could extend lifespan. His paper was published in the 1980s but it was not Vol 61 No 1 / the biologist / 29 INTERVIEW Professor DAME LINDA PARTRIDGE Using nematode worms, scientist Michael Klass discovered that mutating certain genes could extend lifespan until 1996 that the exact identity of the genes was discovered. Are these genes present in humans too? What prevents us from increasing the lifespan of humans? Well, you can’t mutate humans. The work being done on humans is not experimental but correlational – there are studies of people in advanced age, especially where it appears to be familial, with lots of siblings living into their 80s and 90s and beyond. They are compared to a control group to look at whether humans have the same genetic biomarkers of ageing. A lot of the work is very promising and suggests we do. Drastically reducing the amount of food an animal has available can also restrict ageing. What is the theory behind that effect? Dietary restriction is one of the oldest models, dating back to the 1930s. It is no small effect, either. In mice you can extend lifespan by about 50%. In experiments, generally, the composition of diet is exactly the same, but the control group has unrestricted access to food and the other group is restricted – up to 40% of what they’d normally eat. You get a dose-response relationship, down 30 / the biologist / Vol 61 No 1 to a certain level of restriction. You don’t want to starve your animals. Eating less probably inhibits the same signalling networks that were discovered in the mutagenesis experiments. When short of food, the animals go into stressresponse mode and increase the activity of processes responsible for quality control in cells and tissues. Essentially, the organism goes into ‘looking after the body mode’ not ‘making babies mode’. What are the side effects of such a diet? There are surprisingly few in animal studies. Wound healing is slower and subjects are more vulnerable to certain viral infections. There are people who do dietary restriction – strangely it’s almost all men – and were they to suffer from a car accident or trauma, they would probably be less able to cope with that. And, when they do get something like the flu, they have to eat up to shift it, so it is not without its downsides. So you’re working on drugs that could reproduce the effect without people having to follow a joyless dietary regime? The idea is that we develop a pill BIOgraphy Professor Dame Linda Partridge DBE is currently the Weldon professor of biometry at the department of genetics, evolution and environment of University College London, director of UCL’s Institute of Healthy Ageing, and founding director of the Max Planck Institute for Biology of Ageing. that has this effect without any of the downsides and without people actually having to restrict their diet in that way, which realistically is off limits to most people. Do you consider it part of your role to look at the social and socio-economic consequences of your research? We are well aware of the demographics and economics of ageing but we are not trying to make people live longer. We want people to be healthier for longer, ideally healthy right up until they die in their sleep. Lifespan has been increasing for 2.5 years per decade since the 1900s and that is set to continue. Ageing is a risk factor in many of the long-term chronic illnesses that we are seeing more of, such as Alzheimer’s and heart disease. What does your role as a director of the Max Planck Institute for Biology of Ageing involve? It is a new institute, part of many Max Planck research institutes across Germany. They decided Professor Partridge is working on ways to keep us healthier for longer ageing is a subject they wanted to look into. I got a call about six years ago from Munich and it has been really interesting setting it up from scratch. I’m one of several founding directors. It’s quite basic science at the moment. The aim is to use animal and cell studies to better understand the ageing process and develop interventions to keep us healthier for longer. If one of the institutes you direct found a way to stop ageing altogether – an immortality pill, Do you have an opinion on this article? Contact us AT [email protected] say – what would you do with that discovery? Whatever our views about it ethically, it is something some people would pay a huge amount of money for if it was discovered so I don’t think – even if we wanted to – we’d be able to keep that quiet or control it. I suppose I just don’t think it’s that realistic. In mammals life seems to be limited to around 200 years at the very most, and so perhaps that might be the upper limit … evolution has had a long time to work on it. Vol 61 No 1 / the biologist / 31 SPOTLIGHT ON Epigenetics At a glance The epigenome, operating above the level of the genome, can change how DNA is expressed Epigenetics is the study of any changes in gene activity not caused by changes in the DNA sequence. Why is it important? Epigenetics explains almost any change in DNA function that is not caused by a mutation. The ‘epigenome’ at its simplest is the cellular machinery that switches on or off certain genes, allowing stem cells to differentiate into all the cell types required to make a human being. Adding methyl groups to DNA (DNA methylation) or modifying histones (the proteins that package DNA) are ways of changing how genes are expressed without changing the underlying DNA sequence. Although exquisitely complex, with one epigenetic change often causing a cascade of further epigenetic changes, researchers can now remodel the epigenome of organisms using these techniques and study the effects. DNA was once thought to be an inflexible code that set out our phenotype from birth, but it is now known that the epigenome, operating above the level of the genome, can change how DNA is expressed throughout our lives, depending on all sorts of factors, such as our environment. As a result, epigenetics is of huge relevance to the study of both development and disease, especially cancer. 32 / the biologist / Vol 61 No 1 variation on a genome-wide scale, while smaller laboratories use this data to answer more specific questions about the mechanisms of disease. There is a high demand for biologists with computational, bioinformatical or mathematical expertise to help process the vast amounts of data produced by epigenetic research. Medical doctors are increasingly moving into epigenetics research fields related to their disease speciality. What careers are available? Its huge potential as a medical treatment means that most epigenetics work is focused on biomedical research. Cancer epigenetics is probably the largest field, with hundreds of institutes worldwide looking to identify biomarkers of the disease and epigenetic drugs to treat it. Huge sequencing programmes, such as the National Institutes of Health’s 10 year Roadmap Epigenomics Project in the USA, are surveying epigenetic Where can I get more information? ■ The Epigenetics Society (es. landesbioscience.com) is an international scientific organisation open to all those interested in the field. The EU-wide network EpiGeneSys.eu provides epigenetics news, research and events for scientists and interested members of the public. ■ The Human Epigenome Project aims to map all the epigenetic variation found on the entire human genome and its website (epigenome.org) contains most of the data and publications from the project so far, as well as details of the contributing organisations. ■ Johns Hopkins University (www.jhu. edu) is a world leader in epigenetics research, topping the list of citations for institutions in the field. In the UK, the Babraham Institute, Institute of Cancer Research and Wellcome Trust Sanger Institute join the many universities actively researching in this area. Name Wolf Reik Profession Head of the epigenetics programme at the Babraham Institute in Cambridge Interests ‘Epigenetic reprogramming’, where epigenetic instructions are removed from a cell to revert it to an undifferentiated, or stem, cell. What does all this ‘dark matter’ in the genome do in these diseases? Interview reprogramme social behaviours by changing the epigenome. What does epigenetically ‘reprogramming’ cells involve? We work mostly with lab mice and all the cell types you can derive from them – like stem cells, liver cells etc. But the process actually happens in vivo, which is how we first came upon it. In normal development, say in germ cells or embryogenesis, there is an enormous removal of epigenetic information in many areas of the genome. In adults, different cells have a different epigenome which, for example, makes liver cells act like liver cells and brain cells act like brain cells. When you form an embryo you need to ‘wipe the slate clean’, meaning the cells afterwards have the potential to grow into any cell type needed. What are some of the aims of this work? Our work has led to a better way of making stem cells, and there are already epigenetic drugs that remodel the entire epigenome in cancer patients. I think in future we will have a more refined approach where we can manipulate specific parts of the genome epigenetically at will, when you see something has gone wrong with it. What does the future hold for epigenetics? There are very many big questions out there – quite basic biochemical ones, but also ones surrounding all the most common human diseases – diabetes, cancer, heart disease. How much is explained by genetics and the environment, and how does the epigenetic dark matter contribute in these diseases? How did you get into this research? I’m a medical doctor, trained in Germany. I did a PhD with one of the pioneers in this area, Rudolf Jaenisch. I became fascinated by thinking about cell differentiation in an epigenetic way, before the field was even called epigenetics. I came to Cambridge and established my own lab, then started the epigenetics programme at Is epigenetics ultimately about answering the ‘nature vs. nurture’ debate? That’s exactly how you can look at it, as an integrator between the genome and the environment. It’s a good mental picture to use but it’s important to know how much there is in that mental picture we don’t know yet. What about the evidence that some epigenetic information is passed on to the next generation? Large scale reprogramming happens and most epigenetic information is lost in the next generation, but it is possible that a small part of it survives. An interesting recent example is the study of mice and smell (Dias, B.G, Nature Neuroscience, 2013) where something that happened in the previous generation appears to have been passed on through inherited epigenetic information. It is controversial, but an interesting possibility. Babraham. Epigenetics is really quite a large industry now, and it’s been fantastic to see the subject grow. Cancers – such as this bladder tumour – are being studied epigenetically What other research does the lab do? A lot of people are starting to look at caste division in insects – at how the difference between workers and queens, who may be genetically identical, can be explained by epigenetic differences. We are particularly interested in a form of wasp that is ‘primitively social’ – that is, the caste is not fixed, is determined quite late, and you can’t distinguish the queen from the workers just by looking at them. A new queen can emerge from the workers if you remove the queen. If castes are epigenetically determined, maybe you can Vol 61 No 1 / the biologist / 33 Reviews SEEING THE LIGHT The Optics of Life – A Biologist’s Guide to Light in Nature The Optics of Life “Up to date, in an enticing style, and pruned of all unnecessary jargon” Sönke Johnsen Princeton University Press, £30.95 It is rare for a book to begin with the author admitting to not being sure why he wrote it. But that is how Sönke Johnsen, associate professor of biology at Duke University, opens his splendid portrayal of the importance of optics in vision, ecology, botany, animal behaviour, neurobiology and molecular biology. It’s also unusual for a scientist, compiling a detailed and comprehensive yet highly accessible monograph, to assert that, while not “conventionally religious”, he is often “overcome by this world” and wishes to share his amazement at “what is all around us”. While commendably up to date, The Optics of Life is also composed in an enticing style, pruned of all unnecessary jargon. It will speak not only to biological scientists, but also 34 / the biologist / Vol 61 No 1 to physicists interested in the countless roles played by light in the natural world. Following introductory chapters on light’s basic properties and the units and geometry of its measurement, Johnsen surveys topics such as absorption, scattering, fluorescence and polarisation. One commentator said that the book would have saved him “a lot of pain” if it had been available when he began his career in photoecology. I recommend Johnsen’s account of light in nature to one group of readers in particular: those about to embark on a textbook of their own. From the first sentence (“Of all the remarkable substances of our experience – rain, leaves, baby toes – light is perhaps the most miraculous”), this is a model of how to infuse high-level scientific information with colour, humanity and even humour. Dr Bernard Dixon OBE Ellen Prager University of Chicago Press, £10.50 Many people may buy this book on impulse having just read the title. It is indeed a treasure trove of facts, relating to the awe-inspiring but less familiar monsters and creatures of the deep. The prevalence of the use of mucous, the intriguing variety of reproduction mechanisms and inspiring use of chemical defences make this an entertaining read. The book provides a rich description of some fascinating varieties of underwater life and how they are essential within ecosystems, as well as the range of anthropocentric values and uses that are attached to them. Some surprising marine organisms are the inspiration for drug development and sources of medicinally beneficial chemicals. These include, among others, antimicrobials from hagfish and the green fluorescent protein in Aequorea victoria. The importance of seafood in our diets is well known, yet the variety consumed by different cultures may raise an eyebrow – such as the slimy hagfish eaten in parts of Asia, or seahorses consumed in China. One chapter warns of the dangers of overexploitation within the last remaining “commons” and highlights the possible consequences. The colour photographs illustrate the beautiful magnificence of only a small number of these creatures. The omission of an index is one minor criticism and although Prager does state that it is not an academic text, there is a substantial bibliography. Sex, Drugs and Sea Slime would be an ideal gift for anyone considering or starting a course in marine biology, but be careful how you phrase that! Alex Waller CBiol MSB DWIGHT SMITH/SHUTTERSTOCK NIKKYTOK/SHUTTERSTOCK Sex, Drugs and Sea Slime: The Oceans’ Oddest Creatures and Why They Matter The green fluorescent protein found in the crystal jellyfish (Aequorea victoria) has inspired drug development, as discussed in Sex, Drugs and Sea Slime Oxytocin, Vasopressin and Related Peptides in the Regulation of Behaviour Elena Choleris, Donald W Pfaff and Martin Kavaliers (Ed) Cambridge University Press, £70.00 In 2005 Nature published a paper that was scarcely believable. The paper reported on experiments using a trust game in which two people were involved in money transfers. Each person was given a certain amount of money and the first one was asked to send some of it to the second. The experimenters then tripled this transferred amount for the second player, who could then choose to send some of it back to the first player. A surprising finding was that a dose of oxytocin given intranasally more than doubled the number of people who sent all their money to the second, who were under no obligation to send any of it back. Here we see a remarkable demonstration of the impact of a simple chemical on a complex human behaviour. The book provides upperlevel undergraduates and beginning graduates with a wide-ranging review of the background material needed to understand the functions of oxytocin and related peptides. The clearly written and well-referenced chapters deal with molecular mechanisms, phylogenetic considerations and clinical applications, as well as effects on human behaviour, and the final chapter suggests potential lines of future research. A well-organised and presented book on a splendidly interesting subject. Malcolm Dando CBiol FSB The Spark of Life: Electricity in the Human Body Frances Ashcroft Allen Lane, £20.00 There are some startling revelations scattered throughout this readable but muddled book. The fact that the founder of the Methodist movement, John Wesley, was a devoted exponent of electrical therapy is a story well told, as is the existence of 6cm sperm in Drosophila. Yet elsewhere the book is confused. Nerve impulses are introduced as pitifully slow, at 0.07 miles per second, but are later said to “race along” at 250mph (which is the same speed). Ashcroft speaks of dangerous electrical shocks being variously rated at 30,000 volts, 500 volts, 350 volts, down to an electric ray at 50 volts. Although she nicely describes arrhythmia, heart attacks and cardiac arrest, she does not mention cardiac failure. Worse, she commends a description of the brain as electrified clay. The pictures aren’t too good, either. There is a neuron without its axon hillock, muscle fibres lacking striations and a wrongly portrayed aorta. The author’s theme is that the electrical charges of ion channels hold the secret to life. This is like arguing that carburettors are the key to supermarket shopping. Cells are far more complex and diverting than you’d suspect from this account. On the jacket is a claim by Bill Bryson that this is a wonderful book. This is the same Mr Bryson who stated that Leeuwenhoek’s brass microscopes were made of wood. He was wrong then, and he’s wrong now. Brian J Ford Advanced Chemistry (2nd Edition) “Another of its notable and topical examples is the use of polypropene to make Australian banknotes” Advanced Chemistry (2nd Edition) Michael Clugston & Rosalind Flemming Oxford University Press, £45.00 A broad and simple summary, of the breadth of chemistry covered up to GCSE level, reminds students of what they learned before starting their A level course. Newland’s octaves and Mendeleev’s periodic law are recapped and the book progresses to atoms, with an introduction to scanning tunnelling microscopes featuring images of platinum and nickel surfaces. Each chapter starts from the basics to help build on a student’s earlier learning. Calculations are illustrated with everyday examples and applications of this knowledge. Chapters finish with practical exam questions and diagrams of subject matter covered, such as the chemistry of an airbag in a car. Other examples of objects and everyday applications include the percentage of recycled steel used in the construction of the ArcelorMittal Orbit in Stratford for the London Olympics in 2012. Another notable and topical example is the use of polypropene to make Vol 61 No 1 / the biologist / 35 REVIEWS How Your Body Works Ancient Woodland: History, Industry and Crafts “A well- written book on a subject that ought to be close to all our hearts” Judy Hindley, illustrated by Colin King Usborne Publishing, £7.99 To celebrate 40 years of children’s publishing, Usborne is releasing 40 of its most loved books, including this colourful and amusing introduction to biology that is remembered fondly by many adults. The book explains how various body parts work by illustrating them as whacky manmade inventions, with Colin King’s familiar little cartoon people operating the madcap machinery. The circulatory system, for example, is a network of canals full of men in boats exchanging gas tanks, while the lungs are a huge pair of spongy bellows with people working various pulleys to inhale and exhale. Simple diagrams and experiments allow readers to find out things about their body with little to no equipment – “rub your thumb up the blue line on your wrist to watch your blood move” is a good example. Critics will inevitably dismiss the educational value and scientific 36 / the biologist / Vol 61 No 1 accuracy of How Your Body Works – the biology is indeed crude and its metaphors can be slightly dubious. Yet to teach very young children the basics about their body and show them how interesting physiology can be, I’ve not seen anything like it. Nearly 20 years after I put the original in my loft, and having studied biology at university, I still think of my brain as a little call centre with people barking orders down the phone to my arms and legs. Tom Ireland MSB Ancient Woodland: History, Industry and Crafts Ian D Rotherham Shire Publications, £6.99 This is a timely publication in respect of the recent survey of the number of remaining ancient trees and woodlands in the UK. Rotherham combines the knowledge and training of an ecologist and landscape historian, presenting both the biological importance of ancient trees themselves plus their role in biodiversity and shaping the British Isles over time. He writes with a deep reverence for ancient trees and clearly appreciates the role they have played, and continue to play, in the landscape and social evolution of the peoples of these isles. His discourse covers the definition of ancient wood; an understanding of the terms; the number and diversity of crafts that arose because of the woodlands; archaeology and ecology of woodlands; and their future. There is no unnecessary rambling or hype, just relevant, easily absorbed and interesting text. There are goodquality black and white and coloured photographs dotted throughout the book, supplementing as well as illustrating the text. For a meagre £6.99 the reader gets a well-written, informative book on a subject that ought to be close to all our hearts. Dr Stephen R Hoskins CBiol FSB Birds and Habitat: Relationships in Changing Landscapes Robert J Fuller (Ed) Cambridge University Press, £40.00 Habitat loss and deterioration are widely acknowledged to be the most important causes of species decline worldwide, and yet the relationship between species and their habitats is often very poorly understood. This has important consequences when we try to predict how species will respond to changing landscapes or climates, or when we attempt to interpret changes we have observed, such as the widespread decline in farmland birds. Birds and their habitats have probably received more than their fair share of research, and Robert Fuller has spent three decades studying this in Britain and Europe. In Birds and Habitat he draws on much of this experience – plus that of more than 30 contributors – to explore the complexities of bird habitat selection and use, mainly in temperate, cultural landscapes. The three parts of the book cover theoretical concepts relating to patterns and processes, case studies of habitat relationships, and wider perspectives, including studies in Australia and Canada. Among the key concepts addressed is the conundrum of what is good habitat. How can we identify it, or for that matter, how do the birds? The answer varies with species, time (breeding and nonbreeding, for example), and spatially (in different parts of a species range or at different stages of a migration). This is a thorough and detailed review which will clearly interest ornithologists and conservation practitioners but many of the early chapters are of value beyond the world of birds and would interest ecologists generally. Dr Ian Powell ELLA HANOCHI/SHUTTERSTOCK Australian banknotes. I particularly liked the example of vanadium chemistry (with suitable photographs) to explain oxidation states. The book finishes with a number of chapters on biochemistry including carbohydrates, proteins and nucleic acids, making this a useful introductory textbook for students wanting to learn basic biochemistry. Dr Amanda Hardy AMSB Members MEMBER PROFILES make a living from watching animals behave! I studied biology (ethology) at Wageningen Agricultural University in Holland and did a PhD on improving the welfare of laboratory mice. In 2000, I came to the UK to work on improving the welfare of pigs. For over 20 years I have been active in applied animal welfare research that is of direct relevance to policy makers. I am the co-owner of a research and consultancy business called Cerebrus Associates. My role is to advise on animal welfare research, information transfer and conduct policy evaluation. Biology is at the heart of so many things – how we treat our animals, what we eat and how we make sure we do not destroy the planet. My husband works for the Society supporting degree accreditation; he liaises with employers about the benefits of the programme. Best behaviour Heleen van de Weerd FSB Social Notices My eureka moment came when my professor impersonated a chicken and talked about the importance of understanding animal behaviour. I could not believe my luck: you could actually A couple of years ago I worked on the evaluation of the EU’s policy on animal welfare, which informed the new EU Animal Welfare Strategy. I am immensely proud that our findings and recommendations have influenced it. My eureka moment came when my professor impersonated a chicken Chief executive Dr Mark Downs is to hold informal sandwich lunches with groups of 40-50 members, or 10-15 Fellows. Places are available on a firstcome, first-served basis. To book, call 020 7685 2564 or email [email protected] I am a lifelong learner. I went back to university in 2007 to train as a pet behaviour counsellor. I was astounded about how little we know about pet behaviour and welfare in comparison to farm animals. I also volunteer at a wildlife hospital, where I can put my love for animals into practice. 6 March Fellows’ Lunch, London 12:30-14:00 Charles Darwin House 15 May Society of Biology AGM 11:30 Charles Darwin House 1 May Members’ Lunch, London 12:30-14:00 Charles Darwin House 20 May Fellow’s Lunch, Cardiff 12:30-14:00 Venue TBC Vol 61 No 1 / the biologist / 37 MEMBER PROFILES JANUARY 2014 ELECTION With my own research group, I largely focus on how limbs develop from small buds into functional extremities. By combining molecular and cellular approaches with mouse developmental genetics, we have fascinating insights into the selfregulatory nature of the feedback systems that control development. To grasp the underlying complexity we now combine experimental approaches with databased mathematical simulations – an exciting emerging field. Rolf Zeller FSB As a boy, I was fascinated to see tadpoles develop into little frogs in ponds. How an egg develops into a fully functional and independent organism has kept me fascinated ever since. My biology teacher inspired me to study molecular biology in the 1970s and after completing my PhD studying frog development – what else – I spent almost 20 years abroad as a researcher before returning to the University of Basel in 2003. As my research works with mice, I realised long ago that open communication is crucial to make people aware of the importance of animal and basic research for medical progress. I do this as part of the Basel Declaration Society, which is an international grass roots organisation. Researchers commit to animal studies adhering to the best and ethically most responsible approaches. I am convinced that such outreach activities help to increase the trust in scientists. For this reason I joined the Society. Rhona Kivlehan AMSB environmental science at the University of Paisley. I spent a couple of years working for a charity supporting people who had an acquired brain injury. I then moved into a customer service role working for a global biopharmaceutical company. Reading about Louis Pasteur, and discovering that personal tragedy motivated him to find cures for infectious diseases, has been inspiring to me. I am the healthcare specialist for a software company called Gael Ltd. Its product, Q-Pulse, helps public and private healthcare organisations manage quality, safety and risk effectively. Being able to combine science and geography seemed like an ideal fit so I did a BSc in 38 / the biologist / Vol 61 No 1 I like to keep up to date with medical microbiology. Neuroscience is a personal interest having worked with people affected by brain injuries. Reading about Louis Pasteur has been inspiring to me I joined the Society as it is crucial that I know the biomedical landscape in terms of current practices and developments. I love spending time with my family and friends, swimming and running. Dr Graham Williams CBiol MSB I am a senior lecturer in forensic science at the University of Huddersfield. I carry out research into various aspects of forensic genetics, including analysis of messenger RNA, microRNA and DNA mixtures. I am also a forensic practitioner, conducting forensic case work for defence lawyers, and editor-in-chief of a new crime scene science journal called CS Eye. My first interest in biological sciences came through a love of sports, which led to a degree in physiology. I became interested in the work of Stanley Prusiner, who carried out the first work related to prion disorders, and I explored this with an MSc at King’s College London. I worked in neuroimmunology at Oxford University and then became a forensic biologist with the Forensic Science Service. I have worked on forensic RNA analysis for six years. It is now capable of identifying body fluids at much lower quantities and with more confidence so I am looking forward to seeing this replace current tests in case work. Initially, I joined the Society for professional recognition and to become a chartered biologist. But since joining I have found the articles and events thoroughly interesting. I maintain an interest in the neurosciences, particularly in prion protein related disorders, but a combination of scuba diving activities and being a black belt jitsu instructor means I don’t get much chance to keep on top of this research. New, Transfer & Chartered Members Affiliate Virginia Abavana, Golboo Abbasian Amin, Najah Abdigani, Sadia Abdullah, Nadhirah Abdullah Mustafa, Jonathon Ackroyd, Lauren Adams, Fatima Adan, Sarah Adefule, Taiwo Ademola, Shekinah Adoasi, Roqia Agha, Amandeep Ahuja, Mosufa Ajmal, Vinayak Alagh, Hajer Albaghdady, Malang Aleer, Carl Alexander, Huda Alfardus, Abdirizak Ali, Amy Allen, Joe Allen, Hasnat Amin, Fabiha Anjum, Daniel Annal, Michael Anthony, Lauren Anzani, Rebecca Armstrong, Emily Ascroft, Munizeh Asmat, Navin Asokumar, Elizabeth Aspinall, Benjamin Atherton, Lydia Atkinson, Jean-Nicolas Audet, Zoe Awadallah, Zaenab Aziz, Roxanne Ba, Asal Babalou, Emily Babbage, Jack Baddams, Iain Ballantine, Penny Banham, Emma Banks, Reina Bannerji, Imogen Barlow, Tizane Barron, Omer Baskan, Nicola Bassett, Lauren Bastianelli, Heather Bate, Adam Bates, Eunice Bediako, Shajida Begum, Shahida Begum-Islam, Alexander Bennett, Jerusalem Berihun, Robert Berkeley, Jordan Bestwick, Simran Bhogal, Anjna Bhudia, Michael Biddle, Thomas Bierton, Adam Bilton, Joshua Birchall, Cameron Blair, Alexander Bones, Zach Booth, Kathryn Borrowdale, Ruth Bower, Hannah Boyes, Ali Bozkina, Alexandra Bradford, Alice Breddy, Joanne Brehaut, Hollie Brissenden, Katie Bristow, Aaron Brown, Amy Brown, Georgie Brown, Javan Brown, Jessica Brown, Rhiana Brown, Nicholas Bryan, Benjamin Buckley, Sarah Bunney, Emmalina Burd, Alice Burnett, Geraldine Burns, Lindsay Burr, Luke Burrows, Alexandra Bushby, David Busse, Amy Byrne, Christopher Bywater, Alan Calder, Ailsa Campbell, Aimee Camplin, Rebecca Carroll, Rebecca Case, Kimberley Cathro, Viktorija Cernisova, Alexander Chadwick, Amandeep Chahal, Ngai Shing Chan, Zoe Chapman, Waiman Cheung, Tasnia Chowdhury, Christodoulos Christodoulou, Chinelo Chukwuka, Natalie Clamp, Richard Clare, Jennifer Clark, Adam Clarke, Emma Clayton, Nissa Cleaver, Melissa Cleese, Martin Clemett, Ashley Cochrane, Farisha Colbourne, Thomas Cole, Alice Colligan, Zoe Connor, George Cook, Oliver Cook, Victoria Cook, Michael Cooke, James Cooper, Roxanne Cottey, Lydia Cranstone, Katya Curran, Rachel Curran, Amy Curtis, Hannah Curtis, Winnie D’Alva, Catherine Dabrowska, Martin Dainton-Smith, Solina Dangleben, Wendy Daniels, Gordon Darby, Michelle Darby, Phylicia Dassardo-Joseph, Farheen Daudvohra, Hannaneh Davatgar, Jodie-anne Davies, Stevie Davies, Thomas Davies, Hannah Davis, Bryony Davison, Jennifer Dawson, Gino De Guzman, Matthew Delaney, Harry Dennish, Sofia Dente, Marisa Di Monaco, Stephanie Dibley, Emma Dixon, Hannah Dixon, Abigail Docherty, Gulbahar Donmez, Meghan Doyle, Katie Dripps, Rebecca Dudley, Scott Dwyer, Bethany Dybacz, Rachel Eastes, Ali Ebrahim, Alice Edwards, Matilda Edwards, Sarah Element, Kate Elliott, Christopher Ellis, Andrea Elser, Emily Elwell, Hamila Elyasi, Sandra Emerum, Dawn Evans, Lauren Evans, Luke Evans, Aine Fairbrother-Browne, Stefan Fairburn, Rebekah Fant, Shaunagh Faughnan, Maria Ferreira Ramos, Sophie Feuer, Claire Alexandra Fielding, Samuel Firminger, James Fisher, James Fitzsimmons, Lewis Fitzsimmons, Shane Flynn, Alan Foster, Timothy Foster, Jamie Fryer, Jordan Fulcher, Chin Fung, Karina Furie, Jack Galloway, Helen Gavillet, William George, Ameera Ghulam, Andrew Gilbertson, Balraj Gill, Jamie Gilman, Alana Giuliani, Abigail Glading, Tom Glen, Anji Gold, Molly Goodfellow, Shagana Gopalakrishnan, Lauren Gordon, Kareem Gosling, Rebecca Gosling, Izzy Gough, Jaime Graham, Isabelle Grant, Heather Graz , Leah Greenhalgh, Mark Greensill, Derenik Gregge, Andris Grigorjevs, Hanna Grimsdale, Danielle Grindley, Michael Gruet, Ayse Gungor, Ankit Gupta, Yuwaraj Gurung, Mehendo Gyaba, Rebecca Hafner, Daniel Haigh, Manal Halhoul, Jessica Hall, Thomas Halsted, Honar Hama-Ali, Jonathan Hamp, Jordan Handley, Grace Handy, Oliver Handy, Maxine Hanson-Nortey, Jack Harney, Jodie Harris, Zoe Harris, Laura Hart, Francesca Hartley, Lawrence Hatfield, Ben Hattrell, Katherine Hawkins, Hazal Hazar, Callum Hedley, Vicki Heeley, Tajay Henry, Mary Hesketh, Grace Highwood, Clive Hill, Jake Hill, Kimberley Hillman, Siobhan Hillman, Rebecca Hock, Matthew Holland, Elliot Hope, Mohammed Hoque, Samantha Horton, Josephine Howard, Sophie Howard, Thomas Howells, Simon Hoyte, Sandra Hughes-Crean, Muhammad Hussain, Laura Hutchinson, Ladan Ibrahim, April Ignacio, Maria Inman, Gemma Innes, Symone Irinoye, Stephen Ives, Mitchell Jackson, Pamela Jackson, Sarita Jadavji, Muriel Jager, Hamzah Jalib, Jennifer James, Lauren James, Anam Jasrai, Marjan Jeddi, Vicki Jefferson, Laura Jeffreys, Sara Jelassi, Ava Jenkins, Imogen Jenkins, Anushka Jeyarajah, Geerthana Jeyathas, Fabien Johnson, Mark Johnson, Sarah Johnston, Carl Jones, Cassie Jones, Christopher Jones, Hannah Jones, Jack Jones, Jordan Jones, Rachael Jones, Jamie Jordon, Yusuf Kabir, Aliki Kadi, Ammar Kahla, Sabiha Karim, Jasmeen Kaur, Anwar Kazim, Amy Keelty, Megan Kenny, Sidra Khalid, Ayesha Khan, Faheem Khan, Henna Khan, Shakil Khan, Matthew Kirby, George Kirke, Jacob Kirwan, Lucy Knowles, Kevin Kombi, Paulina Kowalewska, Juhi Kumar, Jessica Lake, Natalie Lamb, Roxanne Langford, Faye Latham, Megan Layton, Phuong-Thuy Le, Nicki Le Page, Aston Leaver, Abigail Lee, Owen Lee, Maanav Leekha, Anthony Lees, Daniella Lefteri, Katrina Leslie, Emma Lester, Robert Lever, Deborah Lewis, Rhiannon Lewis, Wincy Liu, Casey Lloyd, Tomos Lloyd-Griffiths, Costanza Lo Cascio, Stefanos Loizou, Katherine Lowther, Boniface Lubowa, Calum MacDonald, Felicity Maclachlan, Agnieszka Magierecka, Damian Magill, Hanna Mahamed, Elisabeth Mahase, Ruqaiya Maimoon, Hadia Malakbaba, Hira Malik, Jessica Mallaby, Akhilesh Manandhar, Eva Mannah, Tanyaradzwa Mantiziba, Sophie MarcelinHorne, Alice Marshall, Joshua Marshall, Ashley Martin, Michael Martyn, Maya Master, Anu Mathew, Jack Maxfield, Conor McCarthy, Lindsay McConville, Christopher McCusker, Rebecca-Jane McElroy, Heather McFadyen, Grant McKay, Alexander McKie, Eleanor McRae, Graeme McWhinnie, Jack Medley, Stephanie Menzies, Danniella Meyrick, Jade Middlemiss, George Middleton, Helen Middleton, Jehanara Mirzai, Jacob Mitchell, Robby Mitchell, Yuria Miyabayashi, Ross Montgomerie, Simon Moore, Sinead Moore, Benjamin Morgan, Joseph Morgan, Jacob Morley, Laura Morris, Joanna Moss, Mohamed Moumene, Sannah Mubashir, Ayeh Muntadhar, Nada Najafi, Thomas Nash, Ann Naylor, Helen Neal, Sarah Nesbitt, James New, Chloe Newton, Courtney Nicholls, Carina Nicu, Jake Nightingale, Paul Norris, Vivek Noruthun, Michael O’Connor, Abi O’Neill, Kimberley O’Neill, Liam O’Reilly, Hannah O’Sullivan, Laura Oakley, Umusalem Odawa, Taiwo Odeleye, Monique Ohiaeri, Bisola Olotu, Said Omar, Adetutu Omogbehin, Joo Phin Ooi, Daniella Ord-Hume, David Osborne, Graeme Overton, Matthew Owen, Catherine Page, Manreen Pandhal, Sharon Panepinto, Laura Parker, Andrew Parnell, Narissa Parry, Devika Parti, Anish Patel, Chirag Patel, Jayna Patel, Shivani Patel, Abhishek Pathak, Panayiotis Patsias, Erin Patterson, Akeema Paul, Lucinda Pavitt, Helena Pearse, Thomas Pearson, Joseph Pennock, Rebekah Penrice-Randal, James Pereira, Jade Perry, Zachary Pierrepont, Charlotte Poole , Darren Archie Poole, Rahul Popat, Lavinia Porter, Sepideh Poushpas, Hannah Price, Tanisha Prince, Rebecca Procter, Bartlomiej Przybyl, Sebastian Punter, Elena Purlyte, Elizabeth Pursey, Ali Qatan, Yasmin Raddie, Akidur Rahman, Muhammad Ramzanali, Eleonore Rayner, Rebecca Rayson, Rebecca Record, Roseanne Reddington, Laura Reddish, Amy Redhead, Louise Relph, Rebecca Revell, Italo Ribeiro Da Costa, Katie Richards, Lee Richardson, Stuart Richardson, Eszter Rimoczi, Danielle Ritchie, Daniel Roberts, Meryon Roderick, Sophie Rogers, Danielle Rogerson, Jennifer Roseblade, Zoe Ross, Minesh Roy, Nicholas Rubio, Lauren Ruddock, Matt Rumble, Beth Rutterford, Paul Ryan, Iram Saddique, Tahir Saeed, Christian Sahakian, Chanka Adheesha Samarauvickma Ranatunga, Megan Sambrook, Filly-May Sams, Csaba Sãrosi, Natalie Sartori, Ali Sarvari, Anna Scapens, Kelly-Jo Scott, Marjorie Sebina, Thomas Shallcross, Safiullah Sharifi, Lucy Sherratt, Amy Sherwin, Rosie Shrimplin, Marshall Sibley, Kemo Sidibeh, Sophie Simmonds, Cassie Sims, Avinesh Singh, Lasotha Sivagnanam, Siransika Sivasiri, Aurora Skar, Hannah Skevington, Alana Skilbeck, James Skinner, Thomas Smallwood, Ben Smith, Beth Smith, Catherine Smith, Charlotte Smith, Isaac Smith, Karl Smith, Lona Smith, Nikki Smith, Lydia Snow, Amrick Soar, Michael Soley, Isabelle Spall, Antonios Spanos, Tom Speight, Callum Spencer, Francesca Spencer, Xenia Spencer-Milnes, Victoria Sprigg, Chrysovalantis Spyrou, Daniel Squair, Salil Srivastava, Abigail Steeples, Monja Stein, Liam Stephens, Dominic Stephenson, Nicola Stephenson, Janey Stewart, Frances Storey, Saqlain Suleman, Sami Sultan, Vishal Suri, Eugene Sutton, Holly Swan, Charlene Swanborough, Shannon Swinchatt, Sharifah Nur Syamim Syed Mohd Sobri, Tiffany Tam, Zoe Tarren, Nechama Tatz, Doug Taylor, Rachel Taylor, Rosie Teasdale, Tegan Thomas, Frederick Tirrell, Alexander Todd, Daniel Tomlinson, Mayur Toory, Louise Topping, Hayley Trestrail, Francesca Trewartha, James Tribble, Zoe Trieu, Christopher Troth, Rebekah Turner, Sarah Tytherleigh, Tanisha Unegbu, Yeliz Onay Uzuner , Glory Valantaine, Benjamin van Soldt, Anthony Varden, Alice Vickers, Melina Videnova, Kajanan Vigmeswaran, Haneelam Virdee, Marc Walton, Chanelle Ward, Morna Watt, Emma Wayne, Anna Westland, Kelly White, Lousie White, Rachel White, Stephanie White, Anya Wichmann, Harriet Wiggett, Laura Wilkiinson, Alice Wilkinson, Alasdair Willett, Catherine Williams, Ceri Williams, Glenn Williams, Hayley Williams, Liam Williams, Jason WilliamsJames, Jun Jie Wong, Zoe Wood, Helen Woolley, Anna Woolman, Zoe Worthington, Efua Yamson, Ziqing Yang, Yanani Yasotharan, Nadia Youssef, Anabel Zelceski. Associate (AMSB) Mohammed Ahmed, Mohanned Al-zahrani, Irene Amadu, Jessica Andrews, Pravin Badhe, Alex Baldwin, Debra Bellaries, Emma Bissett, Lily Brinn, James Britton, Georgia Brown, David Butler, Thane Campbell, Wai Yin Chan, Carly Chandler, Victoria Clark, Thomas Clay, Robert Compton, Gwen Cowley, Rory Craig, Tony Dickson, Rachel Dolan, Daniel Duddy, Josephine Duncombe-Moore, Stuart Elsom, Iseabail Farquhar, Graham Fisher, Emma Gaskell, Tobias Giles, Florence Gower, Kyle Grant, Rhys Grinter, Suzanne Harris, Sophie Hart, Cath Hodsman, Kathryn Hubbard, Sami Idris, Alannah Jackson, Nevena Karapavlovic, Anastasios Stylianos Karountzos, Emma Kelson, Steven Kirby, Carlos Martinez Perez, Coralie Martlew, Philip McCorquodale, Alice McEnnerney-Whittle, David Mentlak, Jiale Mi, Jo Middleton, Sybille Mittmann, Sophie Monkman, Matthew Parslow, Victoria Pell, Timothy Rae, Michelle Reeve, Michelle Reston, Miriam Ries, Lauren Samet, Leo Schlesinger, Antony Scimone, Jean-Francois Selfslagh, Sarah Stiffel, Andrea Strakova, Harriette Taylor, Abbey Thorpe, Gillian Ward, Ruth Warren, William Watts, Laura Wells, Thomas Wells, James Yeomans. Member (MSB) Matthew Abbott, Richard Ackon-Eghan, Emmanuel Adukwu, Mary Apetorgbor, Danen Appasamy, Nicholas Armstrong, Sam Ballantyne, Helen Belfeild, Clare Bird, Chelsea Brain, Robert Brand, James Brown, Elizabeth Bryce, Caroline Buchanan, Anwen Bullen, Rosalyn Chandler, Caroline Collins, Stephen Cooper, Philip Copestake, Michael Cowley, Clive DaCosta, Paul Dauny, Hewan Degu, Raffaella Di Summa, Nicky Dodsworth, Christopher Durrant, Temitayo Fakeye, Rachel Gibbs, Marcus Gould, Elisabeth Green, Sheena Haddow, Zuhair Haggar, Jennifer Hare, Lara Harrup, Attia Hasnain, Niamh Healy, Natasha Hill, Amy Holt, David Hope, Belinda Hornby, Julia Hughes, Manisha Jalan, Neil James, George Johnson, Hilal Khalil, Jon Kudlick, Conor Larkin, Paul Laurance-Young, Emma Lees, Richard Leighton, Laura Lim, Katie Lloyd, Martyn Lowe, Nessie Luambano, Nafees Malik, Delphina Mamiro, Daniel Martin, Holly Matthews, Alexander McAuley, Jalal Miah, Alistair Moore, Heather Moore, Michael Morgan, Christopher Morris, Mark Mossop, Pauline Mounjouenpou, Neil Murray, Sarah Newstead, Beth O’Connell, Kathrin O’Hagan, Przemyslaw Ociepa, Sarah Odoi, Ehigbai Oikeh, Wing-hang Pang, Iraklis Papageorgiou, Elizabeth Parfitt, Sujata Patel, Maria Penas Redondo, Franck Péron, James Poulter, Graham Purdie, Caroline Richardson, Leigh Rickelton, Alan Roscoe, Johar Roy, Jesvin Samuel, Abdul Seckam, Camilla Sewhdat, Matthew Simmonte, James Sleigh, Julia Smith, Stephanie Smith, Gareth Staton, Cameron Stewart, Ilona Stezowska, Harley Stoddart, Sangeeta Suman, Martin Taylor, Michelle Taylor, Subathra Tharmaseelan, Rachel Thurston, Cindy Underwood-Fowler, Aidan Vey, Nina Wambiji, Victoria Waters, Paul Weatherall, Andros Wishart, Christine Woodcock, Claire Wordley, Ka Kei Wu, Yuxin Wu. Fellow (FSB) Clementina Adenipekun, Paul Andrews, Chike Anibeze, Richard Apps, Raymond Ashton, Kyriacos Athanasiou, Maria Balda, Ian Bateman, Nicholas Bexfield, Mervyn Bibb, Jackie Campbell, Kwok Chan, Michael Clark, Richard Cook, Jack Coughlan, Kim Dale, Philip Damiani, Julian Dye, John Elvin, David Garnett, John Gatehouse, Melvyn Goodale, Sheila Graham, Joseph Gray, Mathew Griffiths, Michael Hill, John Hines, Gordon Jamieson, Gareth Jenkins, Pamela Johnstone, Lucy Jones, Alistair Jump, Baljit Khakh, Gareth King, Andrew Lamb, Susan Lanham-New, Andrew Loudon, Troy Margrie, Jan Martin, Brian Merrell, Arno Muller, Victor Nsereko, Mary Oliver, Peter Openshaw, John Overington, Meg Parkinson, Sarah Perfect, Jeremy Pritchard, Richard Reece-Jones, Cedric Richmond, Graham Scarr, Stephanie Schorge, Richard Stafford. Registered Scientist (RSci) Theodoros Laftsoglou AMSB, Craig Mackay MSB, Mittal Shah MSB, Semerab Tewolde MSB, Nieky L.J.N. Van Veggel MSB, Shiraz Ziya AMSB. Registered Science Technician (RSciTech) Carly Chandler AMSB, Victoria Clark AMSB, Gillian Devereux MSB, Tony Dickson AMSB, Steven Kirby AMSB, Martyn Lowe MSB, Bernadette McIlwaine (Affiliate), Sangeeta Suman MSB, Gillian Ward AMSB. Chartered Biologist (CBiol) Marja Aberson MSB, Lee Bollen MSB, Susie Coyle MSB, Katharine Gammon MSB, Ines Blanco MSB, Ross Graham MSB, James Green MSB, Wai Lung Lai MSB, Jan Martin FSB, Angela McDermott MSB, Philip Rogers MSB, Michael Smyth FSB, Leo Lap Yan Wong MSB. Chartered Scientist (CSci) Simon James Benton MSB, Melvyn William Cook MSB, Gimara Duncan MSB, Osahon Osadolor MSB, Martyn Jonathan Stenning MSB. Vol 61 No 1 / the biologist / 39 Branches EVENT REPORTS Beds, Essex & Herts EVENTS CALENDAR Devon & Cornwall IT’S A SMALL WORLD Wednesday 12 March 2014 18:00 Following the AGM at 18:00, Professor Richard Handy will lecture on the wonders of nanotechnology – its applications and the risks and benefits of such technology. Meet at Devonport Lecture Theatre, Portland Square Building, Plymouth Campus, University of Plymouth, Drake Circus, Plymouth, Devon, PL4 8AA. Contact Chris Fry mail@ christinefry.plus.com or 01395 278556 to confirm attendance. For more details and to book a place on an event, see the Branch Contacts on page 45, or visit the Events page of the Society website. Beds, Essex & Herts JORDANS MILL VISIT Saturday 22 February 2014 11:30 A history of Jordans Mill and the development of its famous breakfast cereal and the Conservation Grade food standard. Adults £5.50, children £2.50. Maximum 12 places so booking is essential. Contact Dr Theresa Huxley on 07785 700 073 to confirm attendance. Please note there is limited access for narrow wheelchairs in the mill. East Midlands REGIONAL SCHOOLS BIOLOGY COMPETITION GUIDED TOUR OF THE NATIONAL STUD Saturday 26 April 2014 11:00 The National Stud is located in Newmarket, the home of the British horse racing industry. The tour of the working stud farm will include the foaling unit, nursery paddocks, and the stallion unit, where three stallions currently stand. Places are limited to 20 and will cost £10 for adults, £8 for concessions. Further information and booking details are on the events website. Take a tour of the National Stud to see some Newmarket runners Saturday 22 March 2014 09:45-14:30 The University of Leicester is hosting a Regional Schools Biology Competition to celebrate National Science & Engineering Week. This year students will be encouraged to think about the future. Juniors from Years 8, 9 or 10 can present a poster and seniors from Years 11, 12 or 13 can submit an essay or podcast. The day will include a buffet lunch. For further details contact Cas Kramer ([email protected]) or Rosemary Hall (rosemaryhall1969@ btinternet.com). is free in the university after 16:30. Family and friends are welcome to attend but reserve places with David at [email protected] West Midlands FAMILY DAY DAFFODIL WALK AND LECTURE Saturday 22 March 2014 10:45-16:30 Walk in Kempley, Gloucestershire, to view wild daffodils, a site of special scientific interest and historic churches, followed by a talk on conservation of wild daffodils. Cost for members and under-18s is £7, non-members £10. This includes morning, lunchtime and afternoon refreshments. Prior booking essential; contact Lesley Payne at [email protected]. uk by 14th March. For queries contact Pam Speed at pamela.speed@ btinternet.com or on 01384 296292. TOXICOLOGY LECTURE Late March/early April Aston University, Birmingham. For confirmation of date and booking arrangements see the Society website. Kent, Surrey & Sussex Yorkshire AGM AND PROSTATE CANCER LECTURE Thursday 27 March 2014 17:30 AGM at the Department of Chemical Sciences, University of Surrey, followed by a lecture entitled ‘Novel diagnostic and therapeutic approaches in prostate cancer’, by Dr Richard Morgan. A free buffet is available from 17:30 in room 3AX01 followed by the AGM at 18:30 in lecture theatre 4AZ01. Dr Morgan’s talk will commence at 19:00. Parking 40 / the biologist / Vol 61 No 1 RETIRED MEMBERS’ LUNCH Thursday 3 March 2014 12:30 An opportunity for those no longer talking biology at work to get together and discuss the life sciences and other topics of the day. Meet at The Food Academy, Leeds City College, Printworks Campus, 123 Hunslet Road, Leeds, LS10 1JY. The cost will be around £10 depending on numbers. Confirm attendance with Barry Canham (barry.canham2@ talktalk.net) by 28th February. www.societyofbiology.org/events COMPUTATIONAL BIOLOGY TALK 15 October 2013 Penny Coggill, a computational biologist at Sanger Cambridge, joined us at the University of Hertfordshire for our AGM. Penny has also worked to support women in their careers, and she told us about the work of the Association for Women in Science and Engineering (AWiSE). The network brings together women with common interests and acts as a source of support, information and inspiration. Penny’s takeaway message was that networking is key to finding out how to improve one’s chances. Scent expert ‘Odette Toilette’ then ran an unusual but fascinating interactive session centred on the senses. Using perfume strips and material of different textures and shapes, the audience explored the human senses. We learned that within the group we all had a tendency to link heavy perfumes to darker colours and lighter floral perfumes to pastels. Dr Theresa Huxley FSB Devon and Cornwall ponies are regarded as endangered because of concerns about their genetic diversity. There are probably about 3,200 tigers left in the world, yet none of our rare livestock breeds have that number. They were developed for narrow ecological niches and predominantly local markets. Wool has been replaced by man-made fibres, most horses have lost their jobs, and many breeds are at risk from culling. There is no public money to support rare breeds and the UK Biodiversity Action plan gives no provision for livestock. The survival of our rare breed livestock remains in the hands of individual farmers and rare breed societies. Mary Jenking East Midlands BLACK, WHITE AND PREGNANT 21 November 2013 Dr Anne Pullen and Dr Gareth Starbuck delivered a lively AGM lecture examining the management practices for giant pandas. Pregnancy – or the lack of – in captive pandas has been the subject of much attention and attracted an interested and engaged audience at the Brackenhurst campus of Nottingham Trent University. Anne and Gareth considered all aspects of the giant panda’s management, from issues with habitat destruction, ongoing conservation efforts, genetic issues Devon and Cornwall chair Mary Jenking presented a Society of Biology Long Service Certificate to former chairman and treasurer Brian Petts. His many years of work with the branch were celebrated with a buffet and lecture on the human spine by consultant spinal surgeon Mr Andrew Clark. UMBERLEIGH FARM VISIT 5 October 2013 A tractor and trailer took us from Umberleigh village hall to visit the Pouncey family farm and learn about rare livestock breeds. We saw pure Devon cattle and others cross-bred with Herefords. We learned about traceable ear tags, animal passports and the risks posed by badgers in spreading TB and as a threat to hedgehogs and ground-nesting birds. After a superb lunch provided by Atherington and Umberleigh WI, Trevor Wilson, one of our members, talked about the diversity of livestock breeds in Devon. Some, such as Red Devon cattle, have been exported all over the world. Other breeds, particularly sheep, remain local and vulnerable, such as the grey-faced Dartmoor, which was hit hard by foot and mouth disease culls. Exmoor www.societyofbiology.org/events The panda’s sex life produced some lively tweets at the East Midlands’ AGM Vol 61 No 1 / the biologist / 41 BRANCHES EVENT REPORTS contraband, land mines and even disease. A cheaper alternative could be to use rats or even insects as they have equally good senses of smell but are quicker to train. Juliet concluded the evening with an overview of current genomics technology with examples of its uses. Dr David Ware CBiol FSB PLANT FASCINATION and the more obvious (and topical) issues relating to reproductive efforts in captivity. Interestingly, the in situ giant panda populations are currently doing well in terms of numbers and reproductive output, although they remain susceptible to environmental changes to their dietary staple of bamboo. The hashtag ‘ntukungfupanda’ promoted some lively tweeting. One tweet in particular summed up the interpretation of captive panda reproduction: “It seems a panda has confusing and disappointing sex too!” Dr Jacqueline Boyd MSB Dr Juliet Dukes presents her genomics of smell lecture Jim Heath shows Kent, Surrey & Sussex members around Wakefield Place represents the only sensory system that projects directly into the brain. She reported that sensitivity to odours differs between males and females and in many animals plays a role in mating behaviour. However in humans this role may be overridden by learnt behaviour. Both went on to conduct an experiment to measure the sensitivity of some students to different smells. We are able to use animals like dogs for their ability to detect 18 December 2013 Wakehurst Place has been described as ‘Kew in the country’ and, with 465 acres of ornamental gardens and temperate woodlands, it affords some spectacular walks. It was made even more interesting by the knowledge and enthusiasm of our guides, Beth Thorold and Jim Heath. As expected, there were few flowers to brighten the landscape in December, yet the gardens still boasted a range of architectural trees, such as the scarlet oak (Quercus coccinea) with its bright red autumn foliage, and Farges’s holly (Ilex fargesii) with its dark green leaves. Laboratory manager Keith Manger and Drs Louise Colville and Rosemary Newton led tours of the millennium seed bank. We were talked through the process of collecting and preserving seeds from some 154 countries and 24,000 different species, including from virtually all the UK’s native plants. Much of the collecting is done by local specialists who know the plants Kent, Surrey & Sussex GENOMICS OF SMELL 16 October 2013 The sense of smell in humans involves a large family of around 1,000 olfactory receptor genes, yet most humans are able to detect an even greater number of odours, thought to be more than 10,000. Drs Natasha Hill and Juliet Dukes from Kingston University gave a lecture on the genomics of smell to members and students at Sutton High School for Girls. Natasha explained the physiology of odour detection, from the structure of the membrane-bound receptors to the initiation of an action potential as the aroma molecule binds and stimulates membrane depolarisation. This process is exceptional in that it 42 / the biologist / Vol 61 No 1 www.societyofbiology.org/events in their area and can collect not only seeds, but also vegetative specimens including flowers in order to confirm their identity. The seed bank is not only a collection of worldwide importance, it is also a research facility, with 20 scientists confronting vital problems such as the breaking of seed dormancy, the storage of the most delicate and recalcitrant seeds, and the biochemical changes associated with the death of seeds from environmental stress. Dr David Ware CBiol FSB Northern Animal Health Conference 27 November 2013 Twenty one final year animal science and agriculture students from Newcastle University hosted a conference to discuss current issues relating to animal health. We managed to raise £605 in donations, organise a strong and diverse range of guest speakers, as well as prepare our own presentations on key topics surrounding our conference title, Animal Health Implications arising from Modern Human Demands. The topics covered in our group presentations included mobility problems and mastitis in dairy cattle, the housing and welfare of poultry, selective breeding in canines and the health problems of exotic animals. Leading race horse trainer Mark Johnston spoke on the ailments affecting the equine species and the approach to these in a thoroughbred stable. Nuffield scholar Paul Robinson talked about his experience in the dairy industry, discussing the welfare and productivity of cattle in ‘megadairies’. To conclude the conference, local veterinary surgeon Sam Prescott gave a thought provoking talk on the care and concerns of exotic animals. The conference attracted a wide variety of guests, including students from colleges in the north east. We would like to thank our donors: the Society of Biology, the British Society of Animal Science, Semex, Brooke Research Ltd, and Dr Jonathan Guy from Newcastle University, without whose generous contributions the conference could not have gone ahead. Bethany Count, Charlotte Dolphin and Matthew Sharp www.societyofbiology.org/events Scotland SCIENCE AND THE PARLIAMENT 13 November 2013 For the past several years the Royal Society of Chemistry has organised a ‘Science and the Parliament’ event on behalf of the scientific and engineering community in Scotland. This year’s theme was science in health. All scientific disciplines have an essential role in tackling global healthcare challenges, but the work of policy-makers is equally important. A presentation by the Cabinet Secretary for Health and Wellbeing was therefore particularly interesting and relevant. The scientific programme included excellent presentations relating to systems medicine, largescale food poisoning outbreaks, water quality, advances in human genome mapping, veterinary vaccine development, advanced medical imaging related to cardiovascular disease, and social and behavioural dimensions of sexual health. Representatives from four political parties in the Scottish Parliament delivered presentations, and inevitably questions were focused on the practical implications for the future of science funding in an independent Scotland. The day concluded with a prize giving for school pupils achieving the most outstanding examination results. Congratulations to: Calum MacDonald, Webster’s High School; Katie Campbell, St Columba’s School; Alice Burnett, High School of Dundee; Donald Taylor, George Watson’s College; Marc Walton, Aberdeen Grammar School; Merike Mikkov, Forth Valley College; Amy Taylor, James Gillespie’s High School; Emily L Miedzybrodzka, George Heriot’s School; Daniel Squair, Perth College UHI. Emma Bissett, from the University of Dundee, was also presented with the Top Biology Student in Scotland 2013 award by Royal Society of Chemistry president Professor Lesley Yellowlees. The event remains a useful forum for the Society and other learned societies in Scotland to project their relevance to government, and to encourage MSPs to consult us on a wide range of issues affecting the country. Lindsay Murray CBiol CSci FSB The gathered recipients of Scotland’s top school prizes and (second from right) Emma Bissett, winner of the Top Biology Student in Scotland 2013 ANNUAL SYMPOSIUM & AGM 16 November 2013 Mindful of ambitious renewable energy targets, our annual symposium focused on biologists’ role in emerging energy technologies. While first generation biofuels – such as diesel from plant oils and ethanol from sugar crops – compete with food production for land, cellulose in plant waste as a potential fuel resource does not. Professor Claire Halpin, from the University of Dundee, explained that the efficiency of the production process is restricted by lignin, the waterproofing and the strengthening component of cell walls. Her research on barley employs genetic technologies to identify genes controlling lignin biosynthesis, in a first step towards the development of new varieties of plant with modified lignin content. Aggressive tidal flows in Orkney waters have placed the islands at the forefront of marine energy development. Dr Jennifer Norris, the research director at the European Marine Energy Centre (which is based in Orkney), addressed concerns over the technology’s ecological impact. Are installations’ moving parts hazardous to marine mammals and diving birds? Does noise and physical intrusion cause species displacement? Evidence is elusive as data collection from remote and hostile undersea locations is difficult, but EMEC’s Vol 61 No 1 / the biologist / 43 BRANCHES EVENT REPORTS Yorkshire EXPLORE THE SHORE DAY AT BOGGLE HOLE integrated approach following multiple and innovative data sources should provide answers. Finally, Dr James Pearce-Higgins, principal ecologist with the British Trust for Ornithology, asked ‘should we get in a spin about wind farms and birds?’ In the UK, where sensitive habitats and favoured sites for wind farms tend not to overlap, evidence does not support serious concern over collision mortality. Nevertheless, James’s study of upland birds at wind farms shows reduced numbers from disturbance at construction sites and in-place turbines, with curlew and snipe particularly vulnerable. Clearly, planning consideration is needed for any wind farm proposals in bird sensitive areas. Dr Russ Clare CBiol MSB West Midlands DR CHRIStopher SMITH MEMORIAL LECTURE 16 October 2013 Dr Chris Smith FSB was a much loved and inspirational scientist who brought enthusiasm, vision and warmth to his many years of service on the West Midlands branch committee. We were delighted that his widow Jenny and his brother John 44 / the biologist / Vol 61 No 1 were able to join over 120 Society members, friends and former colleagues at Aston University for this memorial lecture. The event was held jointly with the British Neuroscience Association, represented by Dr Rhein Parri of Aston. Our guest speaker, Professor Eef Hogervorst of Loughborough University, presented a scholarly and engaging lecture on ‘Reducing dementia risk through lifestyle changes: when to do what?’ Professor Hogervorst explained that many headline-grabbing interventions such as oestrogenreplacement therapy and eating tofu have positive effects in younger people, but can be harmful for over 60s. The evidence shows that maintaining muscle mass is important – three 20 minute resistance band workouts a week and five 30 minute aerobic exercise sessions are a good guideline. Sudoku and stretch yoga might be good for other things, but cycling and dancing are better for dementia prevention. The big message emerging from the research is, in Professor Hogervorst’s words, “You already know what to do!” The guidelines are the same as for heart disease prevention, with an emphasis on aerobic exercise, a good balanced diet and healthy relaxation. Pamela Speed CBiol MSB Over 120 West Midlands members attended the Dr Christopher Smith Memorial Lecture. Left to right: Dr Rhein Parri of the British Neuroscience Association, guest speaker Professor Eef Hogervorst, Chris Smith’s widow Jenny and his brother John. 5 October 2013 Jane Pottas and Paula Lightfoot led a successful ‘Explore the Shore’ day at Boggle Hole. Boggle Hole Youth Hostel (below) acted as our venue and managers Andy and Peta Nugent and their staff could not have been more hospitable. The hostel is conveniently situated only a stone’s throw from a pristine rocky shore. Fourteen members took part, including individuals and families and a couple of dogs. They enthusiastically searched out species to identify on the shore and back in the classroom at the hostel. Around 100 species were identified including a stalked jellyfish, several species of fish, snails, bryozoans and more than 30 seaweeds. All records for the day will be uploaded to the National Biodiversity Network database. The weather was wonderfully warm and sunny, everyone had a good time and we all learned something new about this fascinating environment. More days on the shore are on the cards. Jane Pottas MSB and there is likely to be food more tailored to individuals. Professor Tim Benton, UK champion for global food security, University of Leeds, said global food security is not just about preventing starvation but also about ensuring peace as “Everyone is only nine meals away from anarchy”. The human population is growing and much of that population is getting richer and richer people eat more. Increasing urbanisation and remoteness from sources of food is also a problem, as are waste and overconsumption: the food waste generated by Europe and North America is equivalent to the whole food production of subSaharan Africa, while over-consumption and obesity causes 20% of deaths globally. Action is needed at international and national level to minimise risks and maintain food supplies. Crop physiologist Dr Eric Ober from the National Institute of Agricultural Botany, Cambridge, reported that yields of cereals are increasing slowly, but over the last few years there have been signs of stagnation so breeding programmes continue. Newer breeding programmes use genes from wheat ancestors to produce a ‘super-wheat’ to provide better resistance to drought, heat and disease. There is a considerable gap between experimental and farm yields (the ‘yield gap’), so farming practice needs to improve to realise that potential. Dr Qasim Chaudhry, Food and Environment Research Agency, York, spoke on how the use of nano-technology will lead to lighter weight, more hygienic and ‘smarter’ packaging that will allow longer shelf-life and less waste. When the packaging includes nano-particles it will be able to detect spoilage, making the ‘use by’ date redundant. Other applications could lead to simpler diagnostics in veterinary practice and pest control, but there remain some concerns about nanoparticles in the environment. Dr Martin Hemingway of ALcontrol Laboratories, Rotherham, reminded us how ‘horsegate’ earlier this year shows just how difficult it is to be sure of what we are eating. But contaminants can be distinguished and even traced to their origin by techniques routinely used in analysis. Michael Smith MSB Branch contactS Beds, Essex & Herts Dr Theresa Huxley [email protected] Devon & Cornwall Christine Fry [email protected] East Anglia Amanda Burton [email protected] East Midlands Rosemary Hall [email protected] Kent, Surrey & Sussex Dr David Ware kentsurreysussex@ societyofbiology.org LONDON Ken Allen [email protected] North Wales Dr Rosemary Solbé [email protected] North Western Glenn Upton-Fletcher [email protected] Northern Dr Michael Rowell [email protected] Northern Ireland Dr David Roberts [email protected] SCOTLAND Dr Jacqueline Nairn [email protected] Boggle Hole Youth Hostel Food, Glorious Food 16 November 2013 Members enjoyed a summary of talks from our Annual Symposium entitled “Food, Glorious Food – what do we need, how do we keep getting it and how safe is it?” Dr Wayne Martindale, research fellow at Sheffield Hallam University, predicted that as the world population reaches 9 billion people by 2050, dietary protein will have to be acquired by other means than from animals. Fungal protein product ‘QUORN’ has a lower carbon footprint than other protein sources. According to Wayne, there will be massively less food wastage in the home, by retailers and processors, www.societyofbiology.org/events Thames Valley Dr Ray Gibson [email protected] Wessex Rachel Wilson [email protected] West Midlands Deirdre Marsh [email protected] Laura Wells was presented with the Society of Biology prize for the best academic performance amongst biological sciences final year students at the University of Worcester. Laura completed her first class degree last summer and is now training to teach biology. Laura (right) was presented the prize by West Midlands committee member Dr Sue Howarth FSB. www.societyofbiology.org/events WESTERN Joan Ashley [email protected] YORKSHIRE Paul Bartlett [email protected] Museum Piece Biological exhibits from around the world #006 Forensic evidence from 1830 The Museum of the Royal College of Surgeons of Edinburgh S ealed within three jars is the physical evidence from a brutal 19th century murder involving a single stab wound to the chest. The central jar contains a 46 / the biologist / Vol 61 No 1 shoemaker’s knife which matches the puncture wound found in the victim’s flesh, on the left, and heart, on the right. This evidence, and more besides, can be found in the museum of the Royal College of Surgeons of Edinburgh. The oldest museum in Scotland, it houses one of the largest historic surgical pathology collections in the UK. Developed as a teaching museum for medics, it opened to the general public in 1832. Two years earlier, in an Edinburgh house, cobbler James Gow stabbed his wife. The forensic and post-mortem evidence from the case were saved and donated to the museum by Alexander Watson, fellow of the Royal College and surgeon at the Royal Infirmary in Edinburgh. He later published the details of the post-mortem and that of other murders he had investigated in his book Homicide by External Violence (1837). Within the central jar is a description of the murder weapon and the case (below). Dated 18th July 1831, it reads: “The knife to which this label is affixed is the knife which James Gow, Shoemaker, stabbed his wife with in 187 High Street about halfpast 10 o’c, night of the 16th, and found by John Nicolson, W.M. and Donald Gordon, D.P., on the Bartisan [balcony] of his dwelling house.” Surgeons’ Hall Museum is open 12:00 to 16:00, Monday to Friday, www.museum. rcsed.ac.uk James Gow’s murder weapon and his wife’s heart are among the exhibits in the Surgeons’ Hall Museum Apply for the Science Communication Awards The competition rewards informative, enthusiastic and engaging public outreach work carried out by bioscience researchers from UK universities and institutes. There are two categories of award: • New Researcher (£750) • Established Researcher (£1,500) For more information and an application form, visit www.societyofbiology.org/scicomm Closing date: Friday 30 May 2014 Crossword Across 1 It has been duly arranged to ignore it (10) 6 Massacre with heads of corpses and gore everywhere (4) 9 New or ancient one’s reappearance in a new form (10) 10 Presumed it includes what identifies family (4) 12 Be in accord with an ecofriendly person for the most part (5) 13 What might be additional beautification - nothing men have time for (5) 14 Relating to the body, this gives indication of state (3) 16 Absorbing nitrogen is not imagined - it is to do with a body organ (5) 18 Current producer alert to need to change (7) 19 Reel breaks but it can be taken back (7) 22 Not even elements of boobs on my chest (5) 24 Hint of oregano in my cheese sauce (3) 25 Some text elements superficial (5) 26 Ordered tapas – often eaten on the Continent (5) 29 Even bits of meat jelly last forever (4) 30 Alarm notices not put out (10) 31 Sort of storm disruption (2-2) 32 Need to deploy safest club – that’s where you get iron out (10) Down 1 2 3 4 5 7 8 Rent to rise? Is ruled out (4) Ribald partying associated with a wedding (6) At home poor dog gets to suffer (5) More desperate about the one who hesitates (8) It takes money and energy to create royal bodyguards (6) Alternating current menu around shows shrewdness (6) Like anteaters eat, need front of 1 2 3 4 5 9 New year and WIN A £25 new format BOOK for this issue’s TOKEN brain teaser 6 7 8 10 11 12 14 13 15 16 17 18 19 20 the clues in italics being words or phrases that have suffered the loss of the same biological constituent. In these clues definitions are normal but subsidiary indications and lengths refer to the truncated version of the answer. For example, if GENE were the constituent, then GENERAL would be entered as RAL and clued accordingly. How to enter 21 22 23 25 24 26 27 28 29 30 31 32 11 15 17 18 19 20 21 23 24 27 28 tongue to be mobile (8) Lot use mixture like salt in the sea (6) A tool for everyone by the sound of it (3) Arabs here possibly resistant to change (6) Disciple he belongs to a new trend (8) Behind with applications? Results in commotions (8) Constellation partly visible overhead (3) Wait on leaders in applied technology to exploit new developments (6) Primarily sardines caught here or other little fish in large numbers (6) Chap, one with a cold, he might need to be confined (6) Lady left fellow and is now on this? (5) Office opening before sun rises – that’s a burden (4) This issue A change to the usual puzzle format this time with all the answers to To be in with a chance of winning a £25 book token please send us your completed puzzles by Wednesday 12th March 2014. Please include your name, address and membership number with your entry – an email address would be handy too. Post your entries to: Crossword, The Biologist, Society of Biology, Charles Darwin House, 12 Roger Street, London, WC1N 2JU. Volume 61 no 1 compiled by Doug Stanford Winners Well done to last issue’s winners, Dr Anjan Banerjee CBiol FSB and Dr James Craig-Gray CBiol MSB. Book tokens on the way. ➜ Last issue’s solution Vol 60 No 6 Vol 61 No 1 / the biologist / 47 Dr MARK DOWNS FSB, CHIEF EXECUTIVE, SOCIETY OF BIOLOGY Final Word A unified voice for biology H enry Ford might have been speaking of the Society of Biology when he said, “coming together is a beginning, keeping together is progress, but working together is success”. As we travel well into our fifth year it is timely to review what progress we have made towards being a unified voice for biology and what the next stage in our own evolution might bring. It is clear there has been a lot of change. Both our individual and organisational membership has grown by over 20%, we have relocated our head office, and staff numbers have trebled. As a result the Society now offers a much wider variety of competitions, grants, training, public engagement, online services and policy work. There is plenty more to develop but it is clear that collaboration has been a critical factor. Both individual members and representatives of our Member Organisations (MOs) have helped us respond effectively to policy questions, ensuring our voice is not only heard but is authoritative and credible. This has made a significant 48 / the biologist / Vol 61 No 1 Policy makers regularly turn to the Society for a formal view, whether on policy or how to tackle a challenge difference to policy makers who now regularly turn to the Society for a formal view, whether it is education policy or how to tackle the challenge of developing new antimicrobials. However, to realise Henry Ford’s vision of success through ‘working together’, there needs to be more to collaboration than working parties on shared interests. Bringing diverse biology interests together under one roof can certainly help. Charles Darwin House is now co-owned by us, the Biochemical Society, the Society for General Microbiology, the Society for Experimental Biology and the British Ecological Society. A new joint property nearby will increase our ability to share costs and develop common outreach and policy work. We expect the building to be in use from July 2014 with even more biology related tenants. Of course these two buildings can’t accommodate every organisation and we also need to continue to seek common goals with our MOs located around the UK. At a recent dinner hosted by Professor Dame Nancy Rothwell for the CEOs and presidents of some of our larger MOs, the Society proposed more integration and higher contributions from MOs to better reflect the significant work the Society now undertakes on pan-biology and pan-science issues. Inevitably there was a lot of debate, but the discussion helped set out a broad plan over the next 10 years involving much more collaboration. Ideas range from, at one extreme, a merger of societies to, at the very least, more sharing of experience and pooling resources. I am delighted to say that, as a first step, the Biochemical Society has agreed to permanently second two full time members of staff to the Society to make common sector goals easier to achieve as well as providing more funds to support both general costs and specific projects. A number of other societies have also committed to greater support and, as a result, the cash contribution MOs make to our overall work will increase by 50% this financial year. We are aiming to announce more detail of this exciting news, including the MOs involved, at the AGM in May. Regional Grant Scheme Grants of up to £500 available to run local events Want to deliver an event in your area? Small grants now available for all Society of Biology individual members Visit our website for more details and to download an application form www.societyofbiology.org/get-involved or contact [email protected] Online shop coming soon... line shop coming soon... The Society of Biology shop helps support our work to advise government, influence policy, advance education and encourage public interest in the life sciences. Our online shop is helps nowsupport open! Online shop coming soon... hop The coming Society ofsoon... 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You can purchase biology gifts, and much advance education and encourage publicwww.shop.societyofbiology.org interest in the lifebooks sciences. biology gifts, books much via our online shop and with Youand can purchase gifts, books and much more via our online sh more viamore ourbiology online shop and with our mail order www.shop.societyofbiology.org n purchase biology gifts, books and much more via our online shop and with www.shop.societyofbiology.org leaflet inleaflet futurein editions The Biologist. et in future editions the Biologist. our of mail order future of editions of the Biologist. l order leaflet in future editions of the Biologist. shop.societyofbiology.org www.shop.societyofbiology.org www.shop.societyofbiology.org www.shop.societyofbiology.org For more information (including a list of accredited degrees) visitinformation www.societyofbiology.org/supporting-life-sciences For more (including a list of accredited degrees) visit www.societyofbiology.org/supporting-life-sciences