product profile

PRODUCT PROFILE
Contents
1
Introduction
2
Marketing Summary
3
Research Monograph
5
Scientific Summary
9
Product Label
10
Approved Claims
11
Safety Cautions & Assessment
12
Age Guidelines for Use/Shelf Life
13
Glossary
14
References & Additional Resources
PRODUCT PROFILES
who we are...
Agel Vision
The Global Leader in Suspension Gel Technology
based Nutritional Products
Agel Purpose
AGEL and our Product Profiles in Innovation,
Research, Quality and Safety provide the necessary
components for a confident, well-informed
community of empowered team members
through:
• Safe and beneficial products
• Clear and organized information
EXO
• Compliance to well-defined systems
1
Marketing Summary
Lose free radicals and gain better health
Variety is the spice of life and helps to sustain it too. By combining a variety of exotic fruits and plant
extracts, EXO provides a complete spectrum of antioxidants that support good health and wellbeing**.
The best natural ingredients
EXO is a unique and perfectly balanced blend of exotic fruits and plant extracts. Some of these
fruits and extracts are already well known and well regarded by those interested in health and wellbeing*. These celebrated sources of health include sea buckthorn, elderberry, and arona to name
a few. But EXO also contains many, many other sources of antioxidants in a rich and tasty blend.
The best are even better together
Each of these exotic fruits and plant extracts is incredibly good for your health, but they are even
better together which means that EXO contains a wider range of nutritive qualities than products
that offer only one active ingredient. EXO’s unique combination of ingredients offers you literally
hundreds of naturally occurring antioxidants in one convenient serving.
Lose free radicals and gain better health**
Antioxidants are essential to living well. They’re also essential to cellular health, thanks to their
ability to neutralize free radicals. What does that mean for you? It means that EXO supports those
body functions that help us cope with the stress of a hectic lifestyle and an environment full of
pollutants. In fact, eliminating free radicals supports healthy cells and helps maintain that young,
vibrant, healthy look and feel**.
EXO
2
*Traditional use clams have not been verified by modern scientific research.
**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to
diagnose, treat, cure or prevent any disease.
Products shown may not be available in every location and where available may be for personal use only.
Research
MONOGRAPH
EXO is has a rich history of traditional use that
is summarized below. Although, traditional has
not been verified by modern scientific research,
there is a growing body of research evidence to
support the use of EXO phytonutrients as a valuable
exo ingredient
supplement to health. EXO can be used for overall health and wellness in much the same manner
that Chicken Noodle Soup is used traditionally to
strengthen and provide support against exposure to
environmental and biological concerns that all of us
face (pollution, virus, germs, longevity, age related
impacts, immune support).
traditional use*
phytonutrient
Concord Grape
Anthocyanidins
Visual acuity
Pomegranate
Polyphenols, flavonoids, vitamin C
Cardiovascular, Circulatory
Cranberry
Anthocyanidins
Urinary, Kidney
Aronia
Anthocyanidins
Visual acuity
Blueberry
Anthocyanidins
Visual acuity
Elderberry
Sambucol
Colds, Fever, Coughs
Acerola
Vitamin C, Bioflavonoids
Antioxidiant
Sea Buckthorn
Vitamin C
Antioxidiant
Rooibos
Phenolic compounds, flavinoids
Immune, chemopreventative agent,
allergies, antioxidant, nervous
tension
Bilberry
Anthocyanidins
Detoxification & Cleansing
Prune
Fiber
Constipation
Noni
Fiber, Polysaccharides,Flavonoids
Urinary, Bowel Irregularities, Resistance
Wolfberry/Goji
Polysaccharides Carotenoids
Longevity, Immune, Vision
Aloe
Polysaccharides
Healing agent
Anti-Inflammatory
*Traditional use clams have not been verified by modern scientific research.
EXO
Product History
& Traditional Use
3
Research
MONOGRAPH
exo ingredient
traditional use*
phytonutrient
Gac
Vitamin E, Lycopene, Carotenoids,
Visual acuity
Mangosteen
Polyphenols, tannins, xanthones
Preventative agent,
immune
Acai
Polyphenols
Antioxidiant
EXO Features
array of phytochemicals with
1 Complex
antioxidant potential
literature suggests a varied
2 Scientific
selection of antioxidants is more
effective than consuming antioxidants
derived from fewer sources.
support to your daily intake
4 Provides
of fruits and vegetables
5 Halal and Circle K kosher certified
6 Free radical neutralization
ORAC rating based on
3 Impressive
a diversity of up to 17 of botanical
based ingredients. ORAC or the
oxygen radical absorbance capacity is
a measure of the antioxidant potential.
EXO
4
*Traditional has not been verified by modern scientific research.
Scientific Summary
EXO FORMULATIONS
EXO occurs in two formulations (European Union and US formulas). The reason for multiple Agel
formulas is to accommodate the specific requirements set forth by the regulating agencies in
each country or market.
•
11 botanical ingredients
Both EU & US Formulation
•
Grape Concord Puree, Cranberry Puree,
Aronia Juice, Bilberry Puree, Blueberry
Puree, Pomegranate Juice, Acerola Puree
(Juice), Rooibos Tea Extract, Prune Puree
(Juice), Sea Buckthorn Puree (Juice),
Elderberry Puree (Juice).
•
The same weight amount and percent of
the fruit/botanical per packet. Both have
18-20 grams of juice derived ingredients per
packet.
•
Prune Puree (Juice) from the fruit of Prunus
domestica. A concentrated source of
phytonutrients that have a long history of
use.
•
EU and US formulas vary in the number of
ingredients that are used to comprise the
juice blend per packet.
US Formulation
•
17 botanical ingredients
•
US ingredients not in EU formulation: Noni
Juice, Lycium (Wolfberry), Aloe Vera, Gac,
Mangosteen, Acai.
EXO
EU Formulation
5
Scientific Summary
KEY INGREDIENTS
Common Ingredients for EU
& US Formulas
•
•
•
EXO
6
Grape Concord Puree from Vitis vinifera fruit extract. A delicious darkly pigmented fruit containing flavanols, anthocyanidin and
proanthocyanidin compounds to neutralize
free radicals. These compounds have been
recognized as an important element of the
Mediterranean diet responsible for good
health.
Cranberry Puree from the fruit of Vaccinium
macrocarpon. A native North American
high in phenolic compounds including
anthocyanidins to provide free-radical
scavenging.
Bilberry Puree from the fruit of Vaccinium
myrtillus. Members of the Vaccinium genus
include Cranberry, Blueberry and Bilberry
and each have a tart tang. Each are superfruits and loaded with phytonutrients to
support health.
•
Pomegranate Juice from the fruit of Punica
granatum. The historical use of Pomegranate
is being actively researched for its
polyphenols and related compounds.
•
Rooibos Tea Extract from the herb of
Aspalathus linearis. An African shrub and
popular tea for the constitution based on
polyphenol content. This tea and other EXO
ingredients do not contain caffeine.
•
Prune Puree (Juice) from the fruit of Prunus
domestica. A concentrated source of
phytonutrients that have a long history of
use.
•
Sea Buckthorn Puree (Juice) from the fruit
of Hippophae rhamnoides. Highly regarded
for its Vitamin C content and loaded with
phytonutrients. This is a popular and
nutritional ingredient from. Asia.
•
Elderberry Puree (Juice) from the fruit
of Sambucus nigra. Another of the darkly
pigmented fruits with astringent properties
from flavonoids and other phenolic
compounds.
•
Acerola Puree (Juice) from the fruit of
Malpighia glabra. Also referred to as Ground
Cherry or West Indian Cherry. Phytonutrient
dense and considered one of the leading
sources of naturally occurring Vitamin C.
Vitamin C is well known for its role in scurvy
prevention thru supporting the body’s
connective tissues including collagen and
skin.
US Formula Ingredients Only
•
Noni Juice from the fruit of Morinda citrifolia.
A tropical and Polynesian shrub with a
chemical profile (proxeronine and xeronine)
that complements the other ingredients and
phytonutrients in EXO.
•
Mangosteen from the fruit of Garcinia
mangostana. An Asian fruit with
polyphenolic compounds including
xanthones. In the same genus of plants as
Garcinia cambogia (key ingredient in FIT).
•
Lycium (Wolfberry) from the fruit of Lycium
barbarum. Also referred to as “Goji Berry”.
A nutrient dense super-food used by
Chinese Olympic athletes.
•
Prune Puree (Juice) from the fruit of Prunus
domestica. A concentrated source of
phytonutrients that have a long history of
use.
•
Aloe Vera from the leaf of Aloe vera or
barbadensis. Nutrient rich ingredient
containing minerals, essential amino acids,
vitamins, and antioxidant phytochemicals.
•
•
Gac from the deeply red fruit of Momordica
cochinchinnensis. This botanical is from
Asia. As the deep red fruit indicates, it is
loaded with pigmented nutrients including
carotenoids, lutein, lycopene.
Acai from the Amazon rainforest. A fruit from
Euterpe oleracea. Rich in phytonutrients
that support overall wellness with more
than 30 times the anthocyanins in red
wine grape. Anthocyanins are reported
to be a key nutrient in the Mediterranean
diet. phytonutrients. This is a popular and
nutritional ingredient from. Asia.
Complementary Products
•
EXO and GRN support a healthy diet of
fruits and vegetables with wide spectrum
of phytonutrients for over-all health and
wellness.
•
EXO and UMI support a strong resistance to
free radicals for enhanced antioxidant and
EXO
immune potential.
7
Scientific Summary
SUPPORTING A HEALTHY LIFESTYLE
A healthy diet, exercise,
& EXO fruit blend nutrients
•
Support healthy and normal aging
•
Complete spectrum of phytonutrients for normal aging process
•
Avoid premature aging
•
Supports against rapid aging processes or premature aging by antioxidant potential and free radical neutralizer
A holistic balanced lifestyle can lead to a synergistic
impact. The following are lifestyle practices that will
complement the use of EXO, diet, & exercise
•
Demonstrate your gratitude through AgelCares.
•
Sleep and recharge yoursystem with rest
•
Learn to relax, meditate and avoid stress
•
Avoid negative environmental influences (excessive sun, industrial pollutants, free radicals, trans-fatty acids, cigarette smoke)
•
Attitude is everything. Be positive.
•
Listen to your body
EXO
8
If you would like more scientific information on EXO, go to the Agel website
(www.agel.com) under products.
Product Label
Take one Agel EXO packet a day
Agel® EXO combines the world’s
most powerful and exotic fruits
and berries—some foreign, some
familiar, yet all extremely beneficial.
It’s a highly concentrated gel made
up of antioxidant-rich fruits and
plants, therefore the efficiency and
health benefits of these important
compounds are greatly enhanced.
Nutritional Supplement
EXO
Patent Pending Suspension Gel Technology.
9
Approved Claims
Key Ingredients
EXO Proprietary Juice Blend
approved
EXO
10
not approved
Agel EXO combines the world’s most powerful
and exotic fruits and berries-some foreign, some
familiar, yet all extremely beneficial
EXO is an anti-oxidant. EXO contains a rich blend of
FDA proven antioxidant phytonutrients.
It’s a highly concentrated gel made up of 17
-phytonutrient-rich fruits and plants, therefore the
efficiency and health benefits of these important
compounds are greatly enhanced.
EXO stimulates the immune system and fights off
cancer before it can become serious.
Variety is the spice of life and helps to sustain it
too. By combining a wide variety of exotic fruits
and plant extracts, EXO provides you with a
complete spectrum of phytonutrients critical to
wellness.
EXO and ingredients are proven safe and effective.
The best natural ingredients. EXO is unique
and perfectly balanced blend of exotic fruits and
plant extracts. Some of these fruits and extracts
are already well-known and well-regarded by
those interested in health and well-being. These
celebrated sources of health include sea buckthorn, mangosteen, and acai to name a few.
But EXO contains many, many other sources of
phytonutrients in a rich and tasty blend.
Get well with EXO.
Say good-bye to the common cold.
Increase your performance.
The best are even better together.
Stay young with the power of EXO and exotic fruits.
Slow down symptoms of aging.
Lose free radicals and gain better health.
Modern research has verified the traditional use of
EXO ingredients (should be “has not”)
What can EXO do for you?
Hundreds of antioxidants. Shields the body from
free radicals. Combats signs of normal, age-related
decline.
Safety Cautions
& ASSESSMENT
1
2
Key Ingredients: Fruits, herbs and concentrates from up to 17 botanicals
Pregnant or lactating women (or those planning pregnancy) should consult their
physician prior to using this product.
medical advice if you are taking medications or if have an existing medical
3 Seek
condition.
5
6
7
8
9
If you are planning a surgery, disclose use of Agel EXO and all other dietary
supplements to your physician.
A dosage of 1-2 Agel EXO packets a day can be safely used by most people.
Additional packets can be consumed as needed. The recommended daily maximum
dosage is 4 packets of EXO.
EXO is intended for adult use. It is not intended for use in young children. Consult
with your healthcare professional prior to using in young children.
Do not use this product if you are allergic to any of the ingredients in EXO.
Many of the EXO ingredients have a long history of safe use as foods and for
traditional medical use.
If you experience any unexpected event or reaction to usage of EXO contact
Agel at 3400 N. Ashton Blvd, Suite 500, Lehi Utah or call 1-801-407-5200 or
1-801-407-8801
EXO
4
11
Age Guidelines
FOR USE
age group class
approximate age
use recommendation
Newborn
Birth to one month of age
Not recommended for use
Infant
One month to 2 years
Not recommended for use
Child
2 years to 12 years
Check physician before use
Adolescent
12 years to 17 years
1 packet daily
Adult
17 years and older
1-2 packets daily or as needed
Agel Guidelines
conditions should be considered when considering use, including weight,
1 Individual
sex, pre-existing medical conditions, sensitivity or allergic reactions to ingredients, use
of prescription medication or other drugs.
2
The adult use recommendation for adults EXO is 1-2 packets daily or as needed. The
term “or as needed” denotes that individuals may select more than 2 packets daily
based on individual need, however, the daily maximum dosage recommended is 4
packets.
should begin Agel product use with one Agel product at the lowest dosage
3 Individuals
and increase dosage and add other complementary Agel products as needed.
EXO
12
Product Shelf Life
Agel EXO has a shelf life of 18 months when stored under ambient conditions.
Glossary
Antagonistic
Having an opposing effect
especially in the interaction of two or more
substances such that the overall action of any of
the substances is less than the action of any of the
individual substances.
Anthocyanidins
Soluble blue to red
pigmented chemical compounds in plants that are
associated with biological activity.
Antioxidant
A chemical compound that
inhibits oxidation and free radicals.
Bioflavonoids
A type of flavonoid and
related to the flavonoids. Based on chemical
compounds with a flavan-3-ol structure. Also
referred to as catechins.
Carotenoids A terpene based organic
compound in plants associated with biological
activity
Cofactor A substance or element that needs
to be present to activate the biological action of a
chemical compound or complex.
Lycopene A bright red carotene compound
found in plants (typically in tomatoes and other
red pigmented fruits) and considered to be an
antioxidant.
ORAC Oxygen Radical Absorbance Capacity
a measure or test of the anti-oxidant potential
of a substance (food, supplement, chemical
compound). A high ORAC value measurement
indicates a high anti-oxidant activity.
Polyphenols A class of organic molecules
comprised of multiple phenol groups. Associated
with metabolic activities such as antioxidant and
anti-aging.
Proanthocyanidins A type of
polyphenol (based on flavonols) present in plants
that provide flavor, protective, antioxidant and other
biological activities.
Synergistic Cooperative action among
distinct parts such that the total effect is
greater than the additive sum of the parts taken
independently.
Detoxification (detox) The process
of deactivating or eliminating harmful substances
from the body.
Flavonoids Plant secondary compounds
Free Radicals A radical occurs when
an electron is removed from a stable atom or
molecule. Radicals are highly reactive compounds
and may trigger undesired activities. Free radicals
are also referred to as radicals.
EXO
referred to as Vitamin P and associated with
vascular capillary permiability (activity).
13
References
•
Agel EXO Finished Product Specifications
S100.01 Revision 18, 2011 and S100.17
Revision 18, 2011.
•
Ikeno Y, Hubbard GB, Lee S, Yu BP, Herlihy
JT: The influence of long term Aloe vera
ingestion on age-related disease in male
Fischer 344 rats. Phytother Res. 2002 Dec;
16(8):712-718.
•
Jellin JM, Gregory PJ, et al. Pharmacist’s
Letter/Prescriber’s Letter Natural Medicines
Comprehensive Database. 11th Edition.
Stockton, CA: Therapeutic Research Facility.
2009
•
Johnson PD. Acerola (Malpighia glabra
L., M. punicifolia L., M. emarginata D.C):
Agriculture, Production and Nutrition. World
Rev Nutr. Diet. 2003;91:67-75. Reivew.
Additional Resources
Agel Product Profiles and Organization
Agel Suspension Gel Technology FAQ
US Regulatory Requirements
European (EU) Regulatory Requirements
Agel Primary Use for All Agel Products
Responsible Use of Agel Nutritional Supplements
Agel Compliant Claim Guidelines for All Products
Agel Product Shelf Life (All Products)
Agel Quality (QA/QC 2011)
Product Profiles Listing of Item Numbers and
Release Dates
EXO
14
Product Certification (Halal and Kosher Lists)
Agel Glossary (All Products)
Agel Product Shelf Life
Agel Quality (QA/QA 2011)
•
The United States Pharmacopeial
Convention. USP Dietary Supplements
Compendium The Authoritative Reference
2009-2010 1st Edition. Rockville, MD. 2009.
doi:10.1155/2012/727630
•
Woolley, Cole. Ageless Nutrition 2nd Edition.
Orem UT: Nutritional Sciences LLC. 2005.