The Role of Fingernail and Tongue Analysis

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The Role of Fingernail and Tongue Analysis
The Role of Fingernail
and Tongue Analysis
LUNULA
and Herbal Practice
PREVENTIVE METHODS DEVELOPED
FROM OVER 10,000 PATIENTS‟ RECORDS
November 18, 2012 – Mt. Pleasant, MI
Tsu-Tsair Chi, PhD
TEETH MARKS
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Tongue Color
 COLOR
 VITALITY
 MOISTURE
1.
2.
3.
4.
 SHAPE
 COATING
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Pink tongue
Pale tongue
Red tongue
Dark red/Purple

Pale Tongue:
Anemia
Red Tongue:
Fever, Heart,
Infection
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Spiky tongue:
Real fever
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2008 Edition
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
Pink Tongue:
Normal
Light coating
on root of the
tongue
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
Shiny areas on
tongue: Anemia
• 2010 Hardcover edition
• Over 120 color pictures
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
Dark Red or
Purple Tongue:
Blood stasis,
Serious
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1
TONGUE DIAGNOSIS
KIDNEY
LIVER

LUNG
 LIVER
SPLEEN
GALLBLADDER
STOMACH
(GI)

 LUNG
HEART
STOMACH
ULCER
Elongated
Tongue
Cracks on
tongue

HEART
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Purple Dots: Blood Stasis
Hypoglycemia
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SPIKY TONGUE
• Tip – Heart/Lung
• Side – Liver/Gallbladder
• Center – Stomach/Intestine
Teeth Marks
Lung
White Coating
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Roadmap-like Tongue
Inflammation
Younger People:
Deficiency of Blood,
Hormone and Chi
Older People:
Digestion, Lack of
stomach acid
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Tongue Ulcer
FEVER
Spikes
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2
Tongue Movement vs. Diseases
• Stiff tongue and movement not easy
– Stroke or cognition
• Deviated tongue
– Whiplash, heavy metals, and stroke
Whiplash
Heavy Metals
Stroke
• Tongue shrinks and is difficult to stick out
– Very serious condition
• Unable to control tongue, slow movements
and/or tongue hangs out:
Deviated
Tongue
– Low IQ (since childhood) or stroke
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Tongue Coating
•
•
•
•
Light white: Normal
White: Lung
Yellow: Stomach
Black: Digestion, Kidney, etc.
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Distribution of Coating
• Root / No Root
• Wet / Dry
• Greasy / Not Greasy
• Grow / Reduce
• Thick / Thin
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FEVER or
LOCAL
INFLAMMATION:
Stomach
Yellowish/White
Coating
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Black Coating
•
•
•
•
•
High fever
Dehydrated
Chronic infection
Black/brown keratosis cell
Digestion and Kidney
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DIGESTION
KIDNEY
Black Coating
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LIVER
Black, Dry,
Spiky Coating
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3
Mirror-Like Tongue
• No coating
• Red color (thirsty, heavy chest, nauseous)
KIDNEYS
– stomach and gallbladder condition
• Serum albumin low
• Tongue cell metabolism retarded
Green/Grey
Coating
– Digestion stopped
• Electrolyte imbalance
• Serious health condition
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Mirror-Like Tongue (Slippery)
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Autoimmune
Disease, etc.
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Coating with
No Root
Peeling
Coating
Serious
Condition
Illness becomes
serious
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Red, dry,
cracking tongue
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Coating Location
SNOW-LIKE
COATING
Low serum
albumin
GALLBLADDER
STOMACH
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• Whole tongue: Stomach and Liver.
• Tip (outside): Stomach initiative.
• Roots (inside): Stomach and Intestine
accumulation
• Left side: Inner Organs (difficult to treat)
• Right side: Outside Organs (muscles)
• No root: Stomach, kidney, spleen (serious)
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Coating in
Center
Inner organs
problem
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4
NAIL CLUBBING
Sign of:
Coating on
Left Side
• Heart problem
SHAPE OR
GROWTH
CHANGE
Dangerous
condition
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• Lung disease
• Cancer
• Parasites
Caused by low oxygen levels in
the blood
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KOILONYCHIA (spoon nails)
• Digestive
problem
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BEAU’S LINES
PITTING
Horizontal indentations across the nails
• Psoriasis
• Chronic
Dermatitis
Nail growth is
interrupted by
severe illness
(heart attack) or
malnutrition
Anemia
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Small
depressions
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TERRY’S NAILS (White nails)
ONYCHOLYSIS
Nail separates from nail bed
• Alopecia
areata
(hair loss)
Opaque nails with a dark band on tip
Psoriasis
Injury
Cancer
Thyroid
disease
Congestive
Heart failure
Fungal
disease
COLOR
CHANGE
Diabetes
Liver disease
(cirrhosis)
Auto-immune
disease
Drug
reactions
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5
MUEHRCKE’S LINES
HALF and HALF NAILS
Dark
longitudinal
streak(s)
• Melanoma
Kidney
Disease
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RED
LUNULA
• Benign
nevus
Renal Failure
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AZURE LUNULA
Cardiovascular Markers
Heart Disease
Systemic Lupus
Erymathosus
(SLE)
Rheumatoid
Arthritis
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Cardiovascular Symptoms
Heart Disease
Tip of tongue is red, ear crease, nail
clubbing, lunulae on pinky
Poor Circulation
Lack of lunulae, cold hands & feet,
numbness of the limbs (If the condition
improves, the lunulae should reappear)
Atherosclerosis
Vertical ridges
Peripheral Artery
Disease
Central nail canal (“fir tree” abnormality)
Stroke/Aneurysm
Cherry angiomas on forehead
Heavy Metals
Protruding blue veins and/or red/black spots
underneath the tongue. Sometimes there is a
metallic taste.
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Silver poisoning, Wilson‟s disease,
quinachrine therapy
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Red dots on tip of tongue
Nail Clubbing
Ear Crease
Lung/Heart (> 50-60%)
Heart (89%)
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Earlobe crease and cardiovascular risk
Chronic circulatory problems allow the vascular
bed in the earlobe to collapse, causing the crease.
1982 study: An earlobe crease plus chest pain,
etc. predicts a heart attack 89% of the time.
Cardiac symptoms without an earlobe crease only
predicts 10% of heart attack cases.
1991 study: patients with diagonal earlobe
creases had higher cardiac mortality rate and
higher number of cardiac events.
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6
Nail Clubbing – Lung/Heart
Nail Clubbing and Heart Disease
Horizontal Ridges: Heart Condition
Hemiplegia
• Paralysis of half of body
• Of 87 patients, 13.8% had clubbing on the
affected side
Infective Endocarditis
• Inflammation of heart lining
• Of 60 patients, 50% had bilateral clubbing
Lunula on the pinky
Heart Condition
Horizontal ridges
Source: Journal of the American Academy of Dermatology. 2005; 52(6): 1020-28
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Peripheral Artery Disease
Stroke/Aneurysm
Central Nail Canal
Cherry Angiomas on Forehead
• Cherry angiomas on
forehead,
• Family history of
stroke/aneurysm, and
• Hypertension
Risk is 23 = 8x higher
than average people
“Fir Tree” abnormality
Salvia, Carthamus, Paeonia, and Ligusticum
Extracts on Cardiovascular Patients (30days)
38.1
36.8
130 patients
38.1
10
5
Fibrrinogen
15
Blood viscosity
20
Microcirculation
26.6
25
Index of thromblastrogram
30
Red blood cell aggregation
35
28.9
0
on Cardiovascular Symptoms of 300 Patients
Symptom
2 weeks 4 weeks
6 weeks
8 weeks
Headache
38.5
69.2
72.7
91.7
Dizziness
40.0
65.0
---
66.7
Cardiac Flutter
57.1
71.4
75.2
80.0
Cold Hands/Feet
12.5
37.5
---
53.3
Numb Hands/Feet
11.1
50.0
---
55.5
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Aging cells may lead to arterial damage
and plaque
Hippophae and Rhodiola Extracts
for Heart, Lungs, Energy
• Study from Washington University in St. Louis, MO
• Mitochondrial function decreases in aging cells,
allowing a reactive form of oxygen to leak
• Reactive oxygen causes damage to blood vessel walls
• The body mounts an immune response to repair this
damage
• Immune cells attract a form of cholesterol that sticks
to arterial walls, causing plaque and eventually
atherosclerosis
Source: Nature. June 2005, Vol. 435
Journal of West China University of Medical Sciences. 1999;30:64.
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Salvia, Carthamus, Paeonia and
Ligusticum Extracts
1991. Japan Health Department.
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40
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•  Mitochondrial efficacy to
utilize oxygen and glucose
for the production of energy
(ATP)
• Repairs/Protects vascular
endothelial cells from free
radical damage (vascular cell
damage contributes to
cardiovascular disease)
LD50 > 40 ml/kg
Reference: Townsend Letter. May 2011; 334.
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7
Hippophae and Rhodiola Extracts
Hippophae and Rhodiola Extracts vs. CoQ10
on Heart, Lung and Energy function
Action
Extracts
CoQ10
Improves mitochondrial
efficiency
+++
+++
Reduces lactic acid
+++
+++
Lowers lactate
dehydrogenase (LDH)
+++
+++
+++
Reduces malondialdehyde
(MDA)
+++
++
+++
Increases superoxide
dismutase (SOD),
glutathione (GSH)
+++
+++
Anti-hypoxia
+++
Reduces cholesterol
+++
++
Reduces triglycerides
+++
+
Extracts
Increases energy within
30 minutes
+++
Trilinolein
Protects vascular
endothelial cells from
damage
+++
Active constituent of Hippophae
and Rhodiola Extracts
Repairs and protect
DNA-damaged cells
Eliminates shortness of
breath
Relieves choking-like
symptoms
+++
Reduces palpitations
+++
EPA
Eicosapentaenoic Acid (20:5)
DHA
Docosahexaenoic Acid (22:6)
Minimizes chest
pounding
CoQ10
+
+++
Action
ASPARAGUS EXTRACT CONTAINS:
• ORGANIC FOLATE
(9 capsules or 3 bags contains > 400 g of organic folic acid)
•
•
•
•
•
•
ASPARAGINASE
ASPARAGOSIDE
GLUTATHIONE
VITAMIN B, C, E
ORGANIC SELENIUM
ORGANIC ZINC
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Asparagus Extract reduces Cardiovascular
Disease Risk by Reducing Homocysteine Levels
Xanthomas (eyelid plaque) may signal
Atherosclerosis, Ischemic Heart Disease,
Myocardial Infarction, High Cholesterol*
Wine Extract reduces cholesterol in
155 patients (3 months)
40
90
80
30
80%
60
28%
20
%
15
10
Folic Acid
(1 month)
Homocysteine
(4 months)
0
• The American Journal of Clinical Nutrition. 2002; 76(4):758-65.
• JAMA. 2002; 288:973-979.
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• 48% higher chance of myocardial infarction
• If present in those under 30 years old,
signals arterial plaque
40
30
20
10
84%
65%
0
*British Medical Journal. 2011; 343:d5497.
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Blue veins under
the tongue
Heavy metal
deposit in gum
• Black- or blue-colored nails
• Dark, protruding veins under the
tongue with red/black spots
• Gum shows dark/blue lines
• Metallic taste in mouth
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50
Triglycerides
25
5
88%
70
Atherosclerosis Index
39%
Total Cholesterol
35
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Silver and
Copper
Poisoning
Heavy metal
deposits
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8
Oral chelating herbal supplement
No Side Effects
Does not strip essential trace elements.
Safe for children (3 years and older) to take.
Kidney patients can take with Asparagus
Extract and use with Bathdetox
• Removes heavy metals through urination and
fecal excretion
• Inexpensive
0.8
0.7
0.6
•
•
•
•
•
Loss of appetite
Hyperactivity
Irregular sleeping habits
Temper tantrums
Lack of concentration
Smilax, Sargassum, Rheum and Allium Extracts
chelate lead in children safely and
reduces/eliminates associated symptoms.
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Advantages of Smilax, Sargassum,
Rheum and Allium Extracts
•
•
•
•
Easy administration
Inexpensive
No side effects
Does not strip
essential elements
• Children (ages 3 and
above) can take
• Kidney patients can
take with Asparagus
Extract and use with
Bathdetox
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Pb2+
Cd2+
Hg2+
Zn2+
EDTA
++++
++++
—
++++
Extracts
++++
+++
+++
—
110 Patients
0.4
0.3
0.2
0.1
0.097
0
1st day
EDTA cannot recover liver damage caused by lead toxicity.
The herbal extracts recover liver damage and do not inhibit
hemoglobin biosynthesis.
10 days
(10 days is one course, 3 courses is a treatment period)
Usage: 3-4 capsules, 3 times a day.
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Smilax, Sargassum, Rheum, and Allium
Extracts on Lead Toxicity
(68 children, ages 3-12)
0.3
2 weeks
g/mL
 Risk of ADHD
0.725
0.5
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Children with Lead Toxicity
Smilax, Sargassum, Rheum and Allium
Extracts vs. EDTA: Chelating Power
0.2
0.24
0.1
0.12
0.0
Smilax, Sargassum, Rheum and Allium
Extracts remove Mercury
0.7
Mercury in urine (μmol/L)
•
•
•
•
•
Smilax, Sargassum, Rheum and
Allium Extracts on Lead Toxicity
Lead in Urine (umole/L)
Smilax, Sargassum, Rheum and
Allium Extracts
0.556
0.6
0.5
0.428
0.483
50 cases
0.4
0.27
0.3
0.23
0.2
0.1
0
Day 0
Day 14
 Zinc level increased from 4.58 to 4.87 g/ml
 Associated symptoms reduced
0
Bubbles in the
urine
28 days
Your kidneys must be in good
condition before undergoing
intravenous chelation.
When bubbles are present in the
urine or edema is present in the legs,
this indicates a kidney problem.
Protocol:
•Asparagus Extract
•Extracts of Rosa and Lygodium
•Extracts of Smilax, Sargassum, Rheum
and Allium
•Extracts of Eupatorium, Cinnamomum,
and Atractylodes
Heart (89%)
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Blue Veins under Tongue
with Red / Black Spots
Has a high chance for bypass surgery.
Protocol: Extracts of Salvia, Carthamus, Paeonia and
Ligusticum + Asparagus Extract + Extracts of Smilax,
Sargassum, Rheum and Allium
14
Metal Flush does not remove essential trace elements and has no side effects
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Earlobe crease
7
Normal mercury in urine is < 0.250 μmol/L
Leg Edema
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9
ANEMIA
DEFICIENCY of
BLOOD,
HORMONE and
CHI
Roadmap-like
Tongue in Younger
People
Concave or
“spoon-like”
nails
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Functions of Angelica, Cyperus,
Astragalus, Salvia Extracts
• Improves anemia and malnutrition
– WBC, especially after
chemotherapy
– RBC,  Hemoglobin
•  Platelets (ITP) by 81%
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Angelica, Cyperus, Astragalus, Salvia
Extracts
Hormone Balance, Menopause, PMS
Angelica, Cyperus, Astragalus and Salvia
Extracts on 280 Women with
Dysmenorrhea (3 months)
50
Recommended for pre- and postmenopausal women as well as men
 Balances estrogen, testosterone, progesterone
  90% PMS PAIN
  Irregular menstruation (75%)
  Abnormal uterine bleeding (93%)
  Menopausal Syndrome (NHRT)
 Promotes fertility in both women and men
Red
spots
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Angelica, Cyperus, Astragalus and Salvia
Extracts on 60 Women with PMS (3 months)
Angelica, Cyperus, Astragalus and Salvia on
120 Menopausal Women (3 months)
Effective Rate (%)
100
90
Overall Effectiveness:
96.67%
96.55
80
70
60
Symptom
% Reduced
Symptom
10
10.71
0
Intermediate
PMS
Light PMS
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Hot Flash
87.37
Painful Intercourse
89.18
Fatigue
62.96
Palpitations
59.60
Headache
55.06
UTI
50.62
Irritability
43.01
Depression
32.26
Joint Pain
29.61
Insomnia
23.72
Malaise
21.63
Dizziness
17.86
Approximately 80% of women over 50 years old will
benefit from the hormone-balancing effect of Chi-F
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Improved
No Effect
% Reduced
50
Heavy PMS
20
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100
93.33
41.07
Overall
Improvement
89%
30
Effective
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110
Effective Rate (%)
48.21
40
• In Women: Cysts, Fibroids, Endometriosis,
Fibrocystic breasts, Female organ cancer, etc.
• In Men: BPH, Prostate Cancer, Testicle
Cancer, etc.
• In Both Men and Women: Diabetes, Insulin
Resistance, Cardiovascular risk, Dementia,
Autoimmune conditions, Abdominal fat, etc.
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10
DIABETES
WEIGHT
MANAGEMENT
SEXUAL
VITALITY
•
•
•
•
CANCER
ESTROGEN
CARDIOVASCULAR
HEALTH
Hormonal Imbalance
Physical Markers of
Estrogen Dominance
HORMONES
AUTOIMMUNE
DISEASE
Red dots on the tongue
Cherry angiomas on the abdomen
White spots on the nail
Facial Hyperpigmentation
White
spots
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Cherry Angiomas on Abdomen
Facial Hyperpigmentation:
Estrogen dominance
Cherry angiomas on the Forehead
• If > 10 to 15 large
ones
– Men: Prostate
Cancer risk
– Women: Breast
Cancer risk
– Or Liver Cirrhosis
in both men and
women
Chloasma, Melasma
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Cyperus, Curcuma and
Astragalus Extracts
• Aromatase inhibitor for women and men
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Extracts of Cyperus, Curcuma, Astragalus
MECHANISM
Extracts of Cyperus, Curcuma and
Astragalus reduces Estradiol
Aldosterone
Corticosterone
11Deoxycortisol
Cortisol
EXTRACTS/
DIM
Cortisone
• Competes with estradiol at estrogen
receptors
•  Belly Fat
• Also for Type II Diabetes patients (with
Diabend and OxyPower
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Estrone
Progesterone
Pregnenolone
17-OH
Progesterone
17-OH
Pregnenolone
Androstenedione
Testosterone
5- reductase
Estradiol
Aromatase
17-OH
estrone
38.84
20
0
Before
16-OH
dehydroepiandrosterone
16-OH
androsterone
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60 patients
40
DHT
Cholesterol
74.52
2-OH
estrone
EXTRACTS
DHEA
80
16-OH
estrone
Aromatase
( Estradiol,  Estrone, Testosterone)
Postmenopausal Women with Fibroids/Cysts
Estriol
10 Days After
Postmenopausal women: Estradiol level < 35 pg/ml
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Extracts of Cyperus, Curcuma and Astragalus
inhibit aromatase expression in ovarian and
endometrial tissue in rats
Extracts of Cyperus, Curcuma and
Astragalus: Aromatase Reducer
• Recommended for pre- and
postmenopausal women
• Recommended for men
• Multiple applications for estrogendominant and hyperaromatization
conditions
Ectopic
endometrium
tissue
Ovarian
tissue
Negative Control
No stains
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Manufacturer
Approval Date
Indication
ARIMIDEX
Oral, $220/month
AstraZeneca
12/27/1995
Breast cancer in
postmenopausal women
AROMASIN
Oral, $224/month
Pharmacia
10/21/1999
Advanced breast cancer in
postmenopausal women after
tamoxifen therapy
Advanced or metastatic breast
cancer in postmenopausal
women
Estrogen-related conditions
(cysts, fibroids, ovarian/breast/
prostate cancer, etc) in men
and women.
FEMARA
Oral, $225/month
Novartis
1/10/2001
Extracts of Cyperus,
Curcuma, Astragalus
Oral, $45-$90/month
No side effects
Dietary
Supplement
Extracts of Cyperus, Curcuma and
Astragalus on 100 Patients with
Fibrocystic Breasts
60
60
50
30
10
0
Effective
Improved
No Change
• 90% improved in 6 months
• 94% of the pain associated with cystic fibrosis had disappeared
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48.0 + 8.5
29.7 + 6.4
Positive control
108.9 + 29.03
149.8 + 33.86
34.7 + 5.2
47.0 + 9.19
100%
85.6%
Herbal extracts group
(28 days)
Aromatase reduction
(Herbal extracts)
Extracts of Cyperus, Curcuma, Astragalus +
Extracts of Bolbostemma + Sea cucumber
on 60 patients with Uterine Fibroids
70
57.6
60
~ 5 months
69.2
6 months
50
30
%
34.1
40
30
20
20
10
0
Effective
Improvement
8.2
10
No Change
0
1994 study from Chang Hai Hospital in Shanghai, China
Overall Improvement Rate of 92% within a 5-month period.
19.0
Effective
Improved
11.8
No Change
*Those with uterine fibroids over 5cm should add
Revivin and Angiostop for better results.
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Factors influencing risk of
Breast/Ovarian Cysts/Cancer in women
I. Long-term Hormone Stimulation
Breast Abnormalities
Long-term Hormone Stimulation
– Among women with fibrocystic breasts for
over 20 years, 17% developed breast cancer
10
Negative control
40
%
I.
30
20
Ovary
(mean + SD)
60
6 months
40
%
Ectopic
endometrium
(mean + SD)
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Extracts of Cyperus, Curcuma and
Astragalus on 255 Patients with Ovarian
Cysts and Endometriosis
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Extracts group after
28 days
Aromatase
expression inhibited
Group
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AROMATASE INHIBITORS
Product
Administration, Cost
Positive Control
Tremendous aromatase
expression
Comparison of grayscale values of
aromatase expression in rat endometrial
and ovarian tissues
II. Obesity/Belly Fat
III. Xenoestrogens
IV. Hyperaromatization
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• 40% women of childbearing age already
develop fibrocystic breasts
• 42%: First time breast cancer diagnosis at 65
years old
• 1 in 6 American women who reach 80 years
old develop breast cancer
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12
Dense Breast Tissue: Risk for Breast Cancer
• More than half of all women have dense breast tissue
• Risk for breast cancer is 5x greater in women with
dense breast tissue
• Senate Bill 791 (CA) – effective 4/1/2012
 Requires that patients be informed of their breast
cancer risk if dense breast tissue is found in
mammogram
Breast Calcification: Precancer
• Small clusters of breast calcification is an early warning
sign of breast cancer
• Should be treated immediately
Progesterone
HRT Increases Breast Cancer Risk
• Listed as “Carcinogenic” under California‟s
Prop 65 since 1988
• A listed substance may be natural, synthetic or
even naturally produced in the body
• Progesterone products should have a warning
label
• England Study: If Estrogen + Progesterone are used
together
– 66% increase in breast cancer incidence
– ~15,000 more cases per year
• If only progesterone is used
– 22% increase in breast cancer incidence
• Total of 20,000 more breast cancer cases every year
Source: NNFA Today. Sep 2004; 18(9)
Even bio-identical hormones may pose a risk
Source: Family Physician. Sep 2003.
Sources: Int J Bioinform Res Appl. 2010;6(4):418-34; Br J Cancer. 2010 Sep 8;103(7):1034-1039.
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II. Obesity and Cancer
Extracts of Cyperus, Curcuma and
Astragalus for Belly Fat
Obese persons have high estradiol,
low testosterone levels
• Breast cancer
– Larger tumor size
– Advanced grade
– Increased nodal
involvement
– Higher mortality
• Prostate Cancer
– More aggressive
tumors
– Higher recurrence
rate
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Plasticizers: Xenoestrogens
DEHP, DINP, BBP, DBP
• Plasticizers as clouding agents
found in sports drinks, juices,
tea drinks, fruit jams or syrups,
and tablets or powders
• Causes cancer and damage to the reproductive
system, heart, kidneys and liver
• Men: Has feminizing qualities, reduces sperm
• Women: Early puberty,  breast cancer risk
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Aromatase converts testosterone into estrogen.
More estrogen means more fat accumulation,
especially in the belly, which has the highest
amount of aromatase. The herbal extracts reduce
aromatase and consequently reduces belly fat.
For weight loss, take with
Extracts of Raphanus, Crataegus, Alisma,
Garcinia, Paeonia and Tyrosine .
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III. Xenoestrogens
(Environmental Hormones)
• Substances that mimic the
effects of estrogen
• Attach to estrogen
receptors and disrupt
endocrine functions
• Common xenoestrogens:
clouding agents, pesticides,
phthalates in plastics, dyes
Underdeveloped white seeds
in watermelons signify
presence of xenoestrogens
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Effect of Xenoestrogens on Men
• Reduces sperm count
– Only ~46 million/ml for men around 20 years old
(Avg 84 million/ml for men 30-50 years old)
– 1940s: avg was 60 million/ml. Now avg is 20 million/ml
• Lowers ejaculation
• Doubles testicular cancer risk
– rate has doubled in the last 40 years
• Increases male breast cancer
– 1973: 86 per 100,000 were twice at risk
– 1998: risk increased 1.08 times
– 2004: 1,600 cases of breast cancer diagnosed
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Extracts of Cyperus, Curcuma and
Astragalus counteract the effects of
xenoestrogens by competing with
estrogen and binding to estrogen
receptors
Hugo Rodier, MD, from Utah
recommends the herbal extracts for his
patients who are exposed to
xenoestrogens
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13
IV. Hyperaromatization of Testosterone
Pregnenolone
Cholesterol
People at risk for Hyperaromatization
have the following conditions:
(High estradiol, Lower Testosterone)
Aromatase
– Overweight (or difficult to lose weight)
– Type 2 Diabetes
• Insulin Resistance  Hypertension
•  Cholesterol
  Triglyceride
• Family history of Diabetes
Estrone (E1)
Progesterone
Androstenedione
DHEA
Testosterone
Estradiol (E2)
Aromatase
Estriol (E3)
Source: Jonathan Wright, MD. “Bio-Identical Hormone Replacement Therapy:
Common Issues and Solutions.” Townsend Letter. Jan 2010.
Extracts of Cyperus,
Curcuma, Astragalus
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Any type of Hormone Therapy
Increases Breast Cancer Risk
Estrogen + Progesterone Study
Years of use
Risk
10 – 15
88% higher than non-users
15 – 20
Double than those using for 10-15 years
Risk keeps increasing with longer durations of
use and never tapers off
Symptoms of Hyperaromatization
(High estradiol, Lower Testosterone)
–Overweight
–Low libido
–Reduced muscle tone
–Gynecomastia
Source: Jonathan Wright, MD. “Bio-Identical Hormone Replacement Therapy:
Common Issues and Solutions.” Townsend Letter. Jan 2010.
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When on Hormone Replacement
Therapy, including Bio-identical
hormones, and birth control pills,
add Extracts of Cyperus,
Curcuma and Astragalus to avoid
hormone-related side effects
Suzanne Somers‟ Interview with
Dr. Jonathan Wright
In any situation, make sure
E3 > E1 + E2
“Women were more likely to be long-term breast
cancer survivors...if they had more estriol (E3)
than estrone (E1) and estradiol (E2)”
Source: Townsend Letter. Aug/Sep 2010: 54-56.
Source: American Association for Cancer Research. April 1, 2012.
122
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Jonathan Wright, MD  Townsend Letter (Jan 2010)
Estrogen and the Prostate
• Estrogen Quotient (EQ)
• 2/16 Hydroxyestrogen Ratio
– EQ > 1: preponderance of
estriol, lower estrogenrelated cancer risk
– EQ = E3 / (E1 + E2)
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Cherry Angiomas on Abdomen: Prostate Problems
– 2/16 ratio < 2 is related to
cancer risk in men, pre- and
postmenopausal women on
BHRT
• E3 > (E1 + E2)
Pregnenolone
Cholesterol
Aromatase
Progesterone
2-OH
estrone
Estrone (E1)
16-OH
estrone
DHEA
Androstenedione
Testosterone
Aromatase
Estradiol (E2)
Estriol (E3)
Extracts of Cyperus,
Curcuma, Astragalus
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DIM
I3C
Red Dots on the Tongue: Prostate Problems
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14
Extracts of Melia, Citrus,
Phellodendron and Salvia
Causes of Abnormal Increase of
Estradiol Levels in Men
 Benign Prostatic
Hyperplasia (BPH)
 Prostatitis
 Hair Loss in men
• Hyperaromatization of testosterone
• Impaired liver function
• Obesity – increases aromatase expression
Add Extracts of Cyperus, Curcuma and
Astragalus for best effects for men
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Biopsy recommended for men
with PSA > 2.5
Disadvantages of Biopsies
• Definite risk of spreading the cancer
• Painful and uncomfortable procedure
• 82% missed cases without biopsy:
 men < 60 years old
Instead watch for these physical signs
indicating high estrogen and possibly a high
PSA level:
• 65% missed cases without biopsy:

men > 60 years old
 Red dots on the root of the tongue
 Cherry angiomas on the abdominal area
Sources: Patient Care. December 2003.
New England Journal of Medicine. 2004; 350(22):2239-46.
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130
Ovarian Cysts, Ovarian Cancer Odds Ratio in the US
• 1:500 women develop ovarian cysts within 5 years
after menopause
• 0.2% develop into ovarian cancer
Breast Cancer Odds Ratio in the US
• 1:22 women 50 years ago
• 1:6 women over 80 years old (year 2000)
• Among newborn girls in 2010, 1:3 will get breast
cancer within their lifetime
Prostate Cancer Odds Ratio in the US
• 1:6 men
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FUNCTIONS
Extracts of Cyperus, Curcuma, Astragalus
•
•
•
•
•
•
•
•
•
•
Fibrocystic breast
Endometriosis
Ovarian cyst/PCOS
Uterine fibroid
Thyroid cyst
Kidney cyst
Liver cyst
Neurofibromatosis
Type II Diabetes
Acne
 Colon polyps
 Cervical cancer
 Breast cancer
 Ovarian cancer
 Uterine cancer
 Prostate cancer
 Testicle cancer
 Lung cancer
 Reduces belly fat
 Competes with xenoestrogens,
reducing their effects
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Extracts of Melia, Citrus, Phellodendron, Salvia
+ Extracts of Cyperus, Curcuma and Astragalus
for Prostate Problems
Benign
Prostatic
Hyperplasia
(BPH)
Prostatitis
Hair Loss in
men
Pregnenolone
Cholesterol
Aromatase
Estrone
Progesterone
DHEA
Testosterone
Androstenedione
Aromatase
Estradiol
5-
reductase
DHT
Estriol
Extracts of Cyperus,
Curcuma, Astragalus
Extracts of Melia, Citrus,
Phellodendron, Salvia
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Normal Testosterone Level
• Decreased depression
• Improved memory
• Adequate levels of DHT correlated with:
– Improved sexual function
– Less aggressive prostate cancer risk
Source: Jonathan Wright, MD. BHRT Symposium. June 25, 2011.
To normalize Testosterone Level, take Extracts of
Cyperus, Curcuma and Astragalus with Extracts of
Melia, Citrus, Phellodendron, Salvia
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Estrogen related to
Diabetes and
Insulin Resistance
 Extracts of Gymnema, Morus, Coptis, Astragalus
 Extracts of Hippophae, Rhodiola
 Extracts of Cyperus, Curcuma, Astragalus
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15
Insulin Resistance, Diabetes, PCOS
Hypoglycemia
• Tongue is red and has
teeth marks
• Since hypoglycemia is a
precursor to Diabetes, and
vice versa, it is important
to regulate blood glucose
levels
Children: Fatty liver
Teeth marks
Skin tags
80% Type 2 Diabetes risk
May also be a colon problem
50% chance colon polyps
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Extracts of Gymnema, Morus,
Coptis, Astragalus
for Type II Diabetes (6 months)
Diabend
Control
Total Cases
195
30
 Blood glucose
 Glucose tolerance
 Insulin receptor sensitivity
 Beta cells of pancreas to produce
more insulin
• Antioxidant
• Regulates lipoprotein metabolism
•
•
•
•
Acanthosis nigricans
Those who have high iron levels in the blood are
not only likely to develop cancer but are 3 times
more likely to develop diabetes.
Group
Extracts of Gymnema, Morus,
Coptis, Astragalus Functions
Dark, wrinkly
pigmentation
Effective
Cases
133
2
Effective Rate
68.2%
7.0%
Insulin Resistance
• Present in at least 1 in 3
men with below-median
serum testosterone
• Associated with
hyperaromatization and
estrogen excess
• If low or below-median
testosterone
(hyperaromatization,
test for insulin
resistance!
• Signs and Symptoms
 Sugar or carbohydrate
craving
 Shaky without food
 Obesity, especially belly
fat
 Skin tags
o 80% risk of Type 2
Diabetes
 Osteoarthritis
o ~80% have
metabolic syndrome
Source: Jonathan Wright, MD. “Testosterone Evaluation, Treatment, Safety.” BHRT
Symposium. Las Vegas, NV. June 24, 2011.
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Estrogen and Cardiovascular
Disease
Cherry
Angiomas on
Forehead
Stroke or
Aneurysm
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•
•
•
•
•
Crack(s) on tongue
Black line(s) on nails
Yellow coating on tongue
Roadmap-like tongue
Geographic tongue (IBS,
Crohn‟s disease)
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Dangers of Excess Estrogen in Aging Males
•
•
•
•
•
Double the stroke risk
 Heart Attack, Myocardial infarction risk
Atherosclerosis chance
Thrombus (blood clot) incidence
 Prostate cancer, BPH risk
Sources:
Int J Cancer. 2006; 118(9):2123-31
Annals of the NY Acad Sci. 2006; 1089: 77-193
Minerva Endocrinol. 2006; 31(1):1-12
J Cell Biochem. 2007; 102(4):899-911
Reprod Toxicol. 2007; 23(3): 374-82
FASEB J. 2007 Nov 30 [Epub].
Basic Clin Pharmacol Toxicol. 2008 Feb; 102(2):134-8
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STOMACH
ULCER
Cracks on
tongue
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16
Stomach or Esophageal Problem
Yellow
Coating
Auricle cyst
Digestive
problems
If GERD is
present
22 = 4x
chance
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Black lines on the fingernails and a
crack on the center of the tongue
often indicate stomach bleeding.
The stool will not often
show if you have minor
bleeding. Stomach bleeding
is caused by acid and
pepsin secretion. If you
have this condition,
digestive enzymes should
not be used.
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Case Study: R.S., 67 y/o/m, esophageal and stomach issues
Extracts of Paeonia,
Atractylodes, Poria
(For teeth marks & crack in center of tongue)
Deep crack
Yellow coating
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50%
Rate (%)
Effective Improved
952 cases
Gastritis
65.7
28.6
40%
Chronic Atrophic Gastritis
47.7
17.4
30%
Gastric Ulcer
79.7
17.0
Duodenal Ulcer
69.5
28.8
Irritable Bowel Syndrome*
50.5
39.8
Diverticulitis/Colitis*
40.3
18.2
29.1%
20%
10%
11.9%
0%
Effective
Improved
No Effect
Digestive Enzymes
Absorption
H. Pylori bacteria
Adjusts stomach/intestinal muscle
contractions
Balances stomach acid
Repairs stomach/intestine membrane
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Extracts of Paeonia, Atractylodes and
Poria for Digestive Disorders
Condition
60%
59.0%
Older People:
Digestion, Lack of
stomach acid
Pale and
shiny
tongue
Extracts of Paeonia, Atractylodes and
Digestron
onDigestive
DigestiveProblems
Problems
Poria on
Roadmap-like Tongue
39-year-old male with
Stomach Cancer
 30% Stomach Cancer
is Stage IV
 16% metastasized
stomach cancer is
HER2 +
 Need Angiostop
(EGFR inhibitor)
– 35% prolongs life
*GI Chi + Psoricaid + Digestron for IBS and Diverticulitis/Colitis
For GERD, take Digestron + Debile
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17
Cancer patients:
Tongue has greasy coating
Markers/Symptoms of Liver Problems
• Dark, branching veins
under the tongue
• Red or dark spots on the
sides of the tongue
(blood stasis spots)
• Thick and wide tongue
• Large cherry angiomas
on the chest and
abdominal area
Stomach Cancer
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Dark, branching veins under the tongue
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Characteristic of Veins under the
Tongue and Liver Conditions
Liver condition (N)
2 veins >2 veins
Thickness
Width
Length
Hepatitis (60)
90%
10%
5.21+0.31 3.34+0.21
5.45+0.30
Liver Cirrhosis (50)
26%
74%
3.08+0.27 3.78+0.30
5.62+0.1
Liver Cancer (40)
45%
55%
3.10+0.4
4.34+0.21
5.63+0.1
n/a
n/a
3.18+0.27 3.34+0.31
5.71+0.42
Fatty Liver (60)
• Spider veins on the
chest and abdomen
• Dark or red bands on
the tips of the nails
• Red palm
• Bloating, dry mouth,
bitter taste, fatigue
• “Panda eye” (dark
circle around eye)
4 or more veins
under the tongue
• Liver cirrhosis
• Liver cancer
Alcohol-induced Fatty Liver: SGOT (AST) level is two times
higher than SGPT (ALT) level. Both levels are moderate-high.
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Cherry Angioma
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Cherry angiomas and spider veins
 An indication that estrogen attacks
peripheral
blood vessels, causing an aneurysm
 Metabolism of too much estrogen causes liver
problems
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Cherry Angiomas on Abdomen
• If > 10 to 15 large ones
–Men: Prostate Cancer risk
–Women: Breast Cancer risk
–Or Liver condition in both men
and women
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162
18
Yellow skin (Jaundice)
Red Palm and Hot
Spider Veins/Skin itching
Liver Cirrhosis
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Extracts of Schisandra,
Bupleurum, Smilax
Fatty Liver, Hepatitis, Liver Cirrhosis
 AST (SGOT)  ALT (SGPT)
 HEPATITIS VIRUS TITER
 JAUNDICE  BITTER TASTE
The herbal extracts stop Hepatitis C RNA
virus replication and expression in 6 days
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Hepatitis A and B, Fatty Liver Studies
• Hepatitis A and B patients: ALT
(SGPT) levels in 47 cases by 73% in
3 months
• Fatty Liver: 100% effective in 7
cases
• Excellent for bloating, bitter and dry
mouth, cherry angiomas, fatigue
LD50: 12.50 g/kg
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167
In vitro study (2002):
Extracts of Schisandra, Bupleurum,
Smilax on Hepatitis C
• The herbal extracts have been
proven to inhibit Hepatitis C
RNA virus replication and
expression in 6 days
• The herbal extracts do not have a
toxic effect on normal liver cells
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Frenula Cyst (Lower)
Frenula Cyst (Upper)
Colon/rectum condition
Intestine/upper colon condition
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19
Multiple Frenula Cysts
3 Factors of Colon Polyps
Factor
 Bowel
irregularity
 Excess bile
from liver
 Excess
estrogen
Serious condition
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Extracts of Amorphophallus,
Angelica, Lycii
• Colon, Intestine Detoxifier
• Regular Bowel Movements
• Balances pH of intestines and
promotes good bacterial
growth
• Cholesterol, Weight Control
• Blood Glucose Regulation
• Healthier, Blemish-Free Skin
Recommendation
Amorphophallus, Angelica, Lycii Extracts
Schisandra, Smilax, Bupleurum Extracts
Mentha and Curculigo Extracts
Cyperus, Curcuma, Astragalus Extracts
Those without gallbladder → high chance of
colon cancer
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Internal Bleeding
Dark
line(s)
on nails
LD50: 45 g/kg
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Geographic
Tongue
• IBS
• Crohn‟s disease
• Lung
• Sinus/allergy
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Symptoms suggest estrogen affects liver and colon
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Inflammatory Bowel Disease related to
Autoimmune Disorders
Studies show that the incidence of autoimmune
problems in people with Crohn‟s disease and
Ulcerative Colitis is greater than those without
these diseases.
For best results, take Extracts of Paeonia,
Atractylodes, Poria with
Extracts of Euphorbia, Sanguisorba, Phellodendron
for Crohn‟s disease and Ulcerative Colitis
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Extracts of Euphorbia,
Phellodendron and Sanguisorba
Colitis, IBS, Diverticulitis
For gastrointestinal infections,
Use immediately
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20
KIDNEY PROBLEM -Black Tongue
Horizontal white line(s) across the fingernail
Kidney problem
Horizontal
white line
30-year-old
Male with
Proteinuria
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Proteinuria
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IgA Nephritis
Half-and-Half nails
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Teeth Marks
Foamy urine
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Serious Leg Edema
Signs of Kidney Problems
•
•
•
•
•
•
•
•
Puffy face when waking up
Foamy urine
Teeth marks on tongue
Edema in legs/ankles
Dark color/puffy under eyes
Half-and-half nails
Horizontal white line or strips on nails
Yellow or black coating on root of tongue
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KIDNEY PROGRAM
• Asparagus Extract
•  Creatinine, Diuretic
• Cordyceps Extract
•  BUN
• Extracts of Rosa, Lygodium, Smilax, Centella
• Proteinuria
• Extracts of Eupatorium, Cinnamomum,
Atractylodes
•  Edema,  BUN,  Ereatinine,  Skin
Itching
Proteinuria
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21
Cordyceps Extract on Kidney
Function of 349 Patients
ASPARAGUS EXTRACT
Extracts of Rosa, Lygodium,
Smilax, Centella
25
24.37
• Diuretic Agent
•  Creatinine levels
•  Renal glomerulus re-absorption
•  Kidney function
Before
20
After
15
15.26
12.4
10
5
13.5
5.2
3.5
2.89
 Urinary Tract Infection  Kidney Stones
 Frequent Urination
 Prostate
 Difficulty urinating
 Gout
3.14
0
BUN
(mg/dl)
Creatinine
(mg/dl)
Hemoglobulin
(g/dl)
RBC
(m/mm3)
Toxicity Study: 480 times of the regular
dose, in mice shows no toxicity
Overall 85.9% improvement
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Extracts of Rosa, Lygodium, Smilax and
Centella on Genitourinary Conditions
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Extracts of Rosa, Lygodium, Smilax, and
Centella on 6,512 cases of
Genitourinary Conditions
In vivo Antibacterial Study:
Extracts of Rosa, Lygodium, Smilax, Centella
vs. Cephalexin
70
N
Effective Rate
Frequent urination
172
82.71%
Acute cystitis
984
71.95%
Vaginitis (Trichomoniasis and Candidiasis)
243
65.84%
30
Kidney stones
221
20
Proteinuria
478
60
50
6,512 cases
64.34%
(3,880)
40
19.78%
(1,288)
10
15.88%
(1,034)
Condition
Urine protein > 3.58 g/L for 2 weeks
Serum albumin < 3.0 g/L, Edema
UTI
0
Effective
Improved
No Change
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Prostatis
1057
288
Source: JTCM. 2003; 44(4):311.
Rat
#
Dose
kg-1/d-1
Saline
20
62.44%
Cephalexin
59.41%
Number of rat survivors
Staphylococcus
aureus
E.
Coli
Bacillus
pycyaneus
Streptococcus
pyogenes Type I
20ml x 7
2
1
1
2
20
1mg x 7
14
13
12
14
Kidney Chi
20
54mg x 7
12
11
7
10
42.48%
Kidney Chi
20
18mg x 7
10
10
7
7
21.53%
Kidney Chi
20
6mg x 7
7
5
5
5
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Skin Dialysis Mechanism
Those who have
frequent bladder infections
should take
Asparagus Extract with Extracts of
Rosa, Lygodium, Smilax, Centella
for excellent results
Great to have when traveling and also
to prevent sexual disease.
Make it part of your first aid regimen.
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Extracts of Eupatorium,
Cinnamomum, Atractylodes
SKIN DIALYSIS FORMULA
Detoxifies through the skin without hurting the
kidneys and liver
Na-,K-,ClIncrease
Electrolyte
Balance
Sweat
Medium-sized Biowastes***
Urea
Excretion
Urea
Cyanate
BUN
Kidney
Medulla
Osmosis
Monoaminoxidase
Poison
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Edema
Norepinephrine
Body Balance
The herbal extracts can remove these biowastes
through the skin: urea, creatinine, uric Acid, cAMP,
purine compounds, aromatic compounds,
polyamines, indoles, phenols, myoinositol, sorbitol,
oxalic acid, etc.
Water
Excretion
Lung
Function
Angiotensin I
Urine
Reabsorption
Norepinephrine
Angiotensin II
Ketone & Anti-Diuretic
Hormones
Kidney
Circulation
Urine
***One of the causes of fibromyalgia is the
accumulation of biowastes. These biowastes
can be removed through the blood (use Vein
Lite) or through skin dialysis using
Bathdetox.
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22
Extracts of Eupatorium,
Cinnamomum, Atractylodes
Case study: 36 y/o/m with Focal segmental
glomerulosclerosis (Autoimmune disease)
90
80
83%
87%

For bladder/vaginal area infection
– Extracts of Rosa, Lygodium, Smilax,
Centella
Half and half Nails
77%
70
Improvement
INFECTIONS
60

50
40
30
For upper respiratory
(throat/esophagus) area infection
41%
26%
20
– Bamboo Extract
10

0
BUN
Creatinine
Proteinuria
Edema/
Skin Itching
Pain/
Fibromyalgia
– Sanguisorba, Phellodendron, Euphorbia
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Lyme Disease
• Caused by tick-borne bacteria
Borrelia burgdorferi
• Regular treatment is through
antibiotics
Erythema
migrans
Rash becomes
bigger
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Markers of Lung
Problems
• Nail Clubbing
• Geographic tongue
• Vertical ridges on opaque nail
• White coating on tongue
• Tongue inflamed around the edges
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Lyme Disease Protocol
Lyme Disease Symptoms
• Categories
Deer tick
Circular/spiral
skin rash
associated with
Lyme disease
For gastrointestinal infection
– Skin
– Respiratory
 Musculoskeletal
 Gastrointestinal
• Skin itches on the bitten area
• Nearby joint pain, then limb numbness
and blurred vision
• Then the infection goes to the blood and
the nervous system
Recommendation
For infection in the…
Bamboo Extract
Respiratory system
Extracts of Rosa,
Lygodium, Smilax,
Centella
Extracts of Eupatorium,
Cinnamomum,
Atractylodes
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Urinary system
To remove toxins
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Bilateral Nail clubbing and Lung Diseases
NAIL
CLUBBING
Pulmonary Diseases
Total cases
Cases w/ clubbing
%
Cystic Fibrosis
73
73
100
Cirrhosis
(Hepatopulmonary syndrome)
14
9
64.3
Hypersensitivity pneumonitis
82
44
53.7
Interstitial Pulmonary Fibrosis
588
289
49.2
Asbestosis
167
72
43.1
Mesothelioma
77
23
29.9
Bronchogenic carcinoma
111
32
28.9
Pulmonary arteriovenous malformation
93
18
19.4
Sarcoidosis
90
11
12.2
Tuberculosis
426
72
16.9
Source: J American Academy of Dermatology. June 2005; 52(6): 1020-28
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23
Geographic Tongue
White Coating
Vertical ridges on opaque nails
Sinus allergy, Lung Problem
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Tongue inflamed around edges
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Extracts of Hippophae and Rhodiola
for the Lungs
Anti-Hypoxia Effect: Herbal Extracts vs.
Rhodiola alone in mice
32
Survival time (mins)
• Lung congestion
(as quickly as 20 mins)
• Anti-Hypoxia
• Energy, Anti-Fatigue
•  Throat clearing
•  Pulmonary and Brain edema
30.6
28
26.4
24
23.4
20
Control
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BAMBOO EXTRACT
Bamboo Extract + Cephalexin more
effective than Cephalexin alone
 Acute and chronic throat and lung
conditions
LD50 > 20g/kg
 Cough with phlegm
 Sore throat
 Runny nose
 Asthma
 Ear irritation in Children
FIRST AID for upper respiratory conditions
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< 40 years old
Duration of
disease
> 10 years
Effective
Rate
81.94%
41-60 years old
> 60 years old
81.2%
32.8%
< 10 years
78.1%
*Cephalexin alone is only 6.1% effective
Overall, Bamboo Extract + Cephalexin is 81.2% effective
for all age groups and duration of disease
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0.125 ml/kg
Extracts
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Effective
Rate
100%
Age
0.125 g/kg
Rhodiola
Bamboo Extract for Oral Candida
• People with low immunity such as diabetes
patients, children, the elderly, HIV patients, longterm steroid users, and cancer patients - More
prone to candida in the mouth and throat
• Antibiotics and/or pain medication are often
unnecessary.
• Instead they should take Bamboo Extract for
candida.
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24
Extracts of Astragalus, Xanthium,
Saposhnikovia on Allergic Rhinitis
Extracts of Astragalus,
Xanthium, Saposhnikovia
BRONCHITIS
PNEUMONIA
60
• ALLERGIC RHINITIS
• SINUSITIS
367 cases
57.2
50
40
%
30
20
22.9
19.9
10
Take before the allergy season starts
0
Effective
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EMPHYSEMA
Improved
No Change
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CANCER
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Only thumbs have lunulae
• Only thumbs have
lunulae (80%)
• Physical signs
Especially if 8 lunulae were present
and then disappear  feel cold
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Physical Signs to Determine Early
Signs of Cancer
Physical Signs to Determine Early
Signs of Cancer
Physical Signs to Determine Early
Signs of Cancer
TYPE OF
CANCER
SYMPTOMS
Colorectal
Cancer
• Frenula cyst
• Shape of stool changes, sometimes with blood
• Soft, light-colored hair on the cheeks on adults
Stomach
Cancer
If the digestive symptoms suddenly change with
severe pain
Esophageal
Cancer
GERD patients who feel like food is stuck in the
throat or it goes down very slowly
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TYPE OF
CANCER
SYMPTOMS
Breast and
Prostate
Cancer
• Red dots on tongue
• Lots of cherry angiomas (>10 to 15) on
chest, may also be Liver Cancer
Cervical
Cancer
Vaginal bleeding after intercourse
Ovarian/
Uterine
Cancer
Sudden vaginal bleeding in postmenopausal
women
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TYPE OF CANCER
SYMPTOMS
Kidney Cancer
Urinary bleeding with no pain
Lung Cancer
• Nail clubbing with chronic dry cough
• Soft, light-colored hair on the cheeks
on adults
Lymphoma,
Leukemia
• Triangular nails
• Nail clubbing
Nasopharyngeal
Brain Cancer
Ear ringing on one side only (For brain
cancer: also headaches and blurred
vision)
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25
Stomach
Esophagus/Stomach
2
Not every RTK drug can target several
cancer processes simultaneously
1
3
Hard lump about 2 inches
above or to the left of the navel
•
•
•
•
•
Lump, thickening or wrinkle
on the auricle
Angiogenesis
Invasion
Metastasis
Proliferation
Inhibition of apoptosis
PDGFR
EGFR
(Gleevec, Nexavar,
Sprycel, Sutent,
Votrient)
(Tarceva, Erbitux,
Herceptin, Iressa,
Tykerb, Zactima)
Angiogenesis

Proliferation

Apoptosis

Lymphomagenesis

Tumor Vascular
Maturation
Inhibition of signal
transduction pathway
intermediates
AKT /
RAS
Nuclear
membrane

LD50 = 4.3g/kg orally in mice
Inhibition of DNA’s
Topoisomerase2
Cell
membrane
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Sea Cucumber Extract inhibits 4 RTKs, associated cancer types
VEGFR
PDGFR
EGFR
FGFR
(Avastin, Nexavar, Sutent,
Votrient, Zactima)
(Gleevec, Nexavar,
Sprycel, Sutent, Votrient)
(Tarceva, Erbitux,
Herceptin, Iressa,
Tykerb, Zactima)
(Votrient)


Lung


Lymphoma


Melanoma








VEGFR
PDGFR
EGFR
FGFR
(Avastin, Nexavar, Sutent,
Votrient, Zactima)
(Gleevec, Nexavar,
Sprycel, Sutent, Votrient)
(Tarceva, Erbitux,
Herceptin, Iressa,
Tykerb, Zactima)
(Votrient)
Bladder




Bone




Brain (Glioma)


Breast



Colorectal


Esophageal

Gastric

Head and Neck

Kidney


Leukemia


Liver











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Sea Cucumber Extract inhibits angiogenesis
as illustrated by thermal imaging
Cancer recurrence rate increases after surgery




Sea Cucumber Extract inhibits 4 RTKs, associated cancer types
Type of Cancer
EGFR, PDGFR, VEGFR, FGFR
Neo-Angiogenesis and RTK
Inhibitor

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Inhibition of growth factor signaling
Induction of
apoptosis
(Votrient)

Cellular motility
Sea Cucumber Extract Mechanism

FGFR

Mitogenesis
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Sea Cucumber
Extract
Meningioma
VEGFR
(Avastin, Nexavar,
Sutent, Votrient,
Zactima)
Metastasis
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Type of Cancer
Sea cucumber Extract can inhibit all 4 RTKs and
Associated Cancer Processes
Breast Cancer
Colon and Lung Cancer
Study : 1,173 breast cancer patients
treated with surgery, 520 had relapse
(20% of premenopausal women relapsed
within 10 months after surgery).
Lung and colon cancer surgery linked
to cancer recurrence.
Source: Intl J Surgery. 2005.

Colon cancer patients who had surgery
had higher relapse rate than invasive
laparoscopy
Source: Lancet. 2002.
Myeloma


Nasopharyngeal

Ovarian



Pancreatic




Prostate




Thyroid

4/11/2005

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6/28/2005
8/24/2005
Between 4/11/05 and 6/28/05, this 42-year-old female patient took no herbs and had a
positive mammogram and ultrasound. Beginning 6/28/05, patient took Sea Cucumber
Extract and results have been remarkable. It appears angiogenesis has receded, which is
the best possible outcome.
- Medi-Therm Imaging
Chance of recurrence and metastasis after surgery:
• Within 2 years – 50%
• After 5 years – 5%
Recommendation: Use an angiogenesis inhibitor like Angiostop
before and after surgery to help minimize recurrence

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26
Sea Cucumber Extract
• Multiple RTK targets (VEGFR, EGFR, PDGFR,
FGFR): more effective
• Also Topoisomerase2 inhibitor
• Used before and after surgery and biopsy to reduce
recurrence
• As a multiple RTK inhibitor, it can be first-line
treatment for better results
• Can be used by itself or with chemo for better and
faster results
• Reasonable cost compared to cancer drugs
TARGETS FOR ANTI-CANCER AGENTS
Bolbostemma/Fritillaria Extract
Inhibition of growth factor signaling
Inhibits G1-S transition in Cell Cycle
Sea Cucumber Ext
Bolbostemma Ext
A disruption in the cell cycle can cause the cell to multiply
uncontrollably, forming a tumor.
EGFR, PDGFR, VEGFR, FGFR
Induction of
apoptosis
Inhibition of signal
transduction pathway
intermediates
Nuclear
membrane
Inhibition of DNA‟s
topoisomerase2
Inhibition of G1-S transition
G1
S
Bone Marrow or Blood Disease
(Lymphoma, Leukemia, Anemia, etc.)

Ensures that damaged or
mutated DNA does not
get passed on to daughter
cells
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NAIL CLUBBING
Cancer
Shell-Shaped/Triangular Nails
Uncontrolled cell
replication is inhibited
LD50: 10.0g/kg
Cell
membrane
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
AKT
• Lung cancer
(opaque nails)
• Lymphoma
• Leukemia
• Breast cancer
• Colon cancer, etc
Whenever you have these nails, check your Hgb, WBC, RBC levels
Nail clubbing and Cancer
Total # of # cases w/
cases
clubbing
Neoplastic Diseases
%
Mesothelioma
(from asbestosis)
77
23
29.9
Bronchogeneic carcinoma
111
32
28.9
Pleural Tumors
21
3
14.3
Lymphoma
40
6
15
Intrathoracic Hodgkin‟s in
children
5
5
100
Nasopharyngeal carcinoma
90
6
6.7
Source: J American Academy of Dermatology. June 2005; 52(6): 1020-28
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Extracts of Hippophae and
Rhodiola
• DNA repair for cancer cells
•  Oxygen (Cancer cells cannot
grow in aerobic environments)
• Mitochondrial DNA repair
• More energy for cancer patients
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Vertical ridges on nails
• Extracts of Hippophae, Rhodiola (DNA repair)
• Extracts of Salvia, Carthamus, Paeonia,
Ligusticum (For cardiovascular conditions)
• Extracts of Cyperus, Curcuma, Astragalus (For
estrogen-related problems)
• Lutein, Bilberry, Alisma, Cornus Extracts (Eye
health, hearing, bones, hair)
• Asparagus Extract (Kidneys,  immunity, heart)
Consumers believe genes and lifestyle affect aging more
than external products
69% of consumers reported the earlier one starts using
age prevention remedies, the better
•
•
•
•
•
Aging
Adrenals
Kidneys
Vitamin deficiency
Peripheral blood
vessel disease
• Neurasthenia
Source: “„Cause‟meceuticals.” Natural Products Insider. July 18, 2011.
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27
Mitochondrial Dysfunction
• When mitochondrial function is low, lactic
acid cannot be converted to energy, causing
acidosis
• Not enough cell energy supply leads to:
–  Muscle strength
– Retarded growth
– Induced epilepsy/seizures
– Heart enlargement
– Heart failure
- Liver disease
- Kidney failure
- Sudden stroke
- Kidney failure
- Diabetes
Extracts of Hippophae and Rhodiola promotes
DNA Repair for Anti-Aging, Healing
• Deficiencies in DNA repair show
– premature onset of neurodegenerative
age-related diseases
– shortening of lifespan
• OxyPower prevents DNA damage and
repairs damaged DNA
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• Adrenals
–Chi Energy
• Lack of stomach acid
–Digestron
Test shows K2Cr2O7-induced
damage of TK6 human
lymphoblast cells, evident
here as the comet tail
24 hours after the extracts
were added, DNA damage
was repaired, as seen by the
absence of the comet tail
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OSTEOPOROSIS
ARTHRITIS
Fingernail easily splits
Extracts of Hippophae and Rhodiola may
protect and repair damaged DNA (Comet Test)
Osteoporosis/Osteopenia
Vertical
ridges like
beads on a
string
Thin Nails
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Extracts of Rehmannia, Corydalis,
Dioscorea, Lycium for Osteoporosis
•
•
•
•
•
Improves bone density
Enhances bone calcium content
Inhibits calcium loss from bones
Does not affect estrogen levels
Recommended for osteoporosis patients who
have or are at risk for estrogen-related
conditions such as cysts, fibroids, breast
cancer, etc
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Extracts of Rehmannia, Corydalis,
Dioscorea, Lycium on Osteoporosis
70
60
54.17%
96 cases
44.79%
50
40
30
20
1.5%
10
0
Effective
Improved
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No Change
Extracts of Gastrodia, Angelica,
Ligusticum Functions
• Pain, Migraine
• Dizziness
• Numbness
• Arthritis
•  Blood Pressure
• Fibromyalgia
•
•
•
•
Nervous System
Muscle Ache
Paralysis
Intervertebral Disc
Herniation
• Calming effect
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28
80
Extracts of Gastrodia, Angelica, and
Ligusticum on 1,137 patients with
Neurological Conditions
76.2
Effective rate (%)
76
Aloe, Coptis, Phellodendron Ointment
MEDICINE
“A Simpler Way to Save Lives”
73.9
72.6
Could a new medication from China change the world‟s approach to
treating burn injuries?
70.6
72
68.8
66.7
68
69.4
67.7
64
60
Pain
Dizziness Fibromyalgia Tinnitus
Lumbar
Disease
Sciatica
Cervical Lumbar Disc
Vertebra Herniation
• Burns/Lesions
• Wrinkles/Acne
• Psoriasis/Eczema

Infection
 Skin Cancer
"The new remedy not only eases pain of burn injuries, according to
proponents, but speeds healing, reduces scarring and drastically cuts
the cost of saving lives. There is no need for bandages, no topical
antibiotics and no sterile isolation. The conventionally treated skin
was rough, scarred and marked by patches of excessive or reduced
pigmentation. The herbal treated flesh was now "supple and
unblemished."
Newsweek. May 7, 1990, page 68
Source: Beijing Medical University. 1997.
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Whole Skin for Burns
Aloe, Coptis, Phellodendron Extracts
(Scar-Free Ointment)
SILVADENE
WHOLE SKIN
ENDORSED BY
JONATHAN WRIGHT, MD
Silvadene
Whole Skin
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Missed Nail
Diagnosis
Make this ointment part of the
FIRST AID regimen in
your home and workplace.
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“Fungal Masquerades”
30 days after
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MELANOMA
could actually be
Squamous Cell
Carcinoma,
Melanoma
15 days after
11 days after
Richard K. Scher, MD,
World Congress
of Dermatology
February 2003
“Amelanotic melanoma occurs more often in the
nail than in the skin.”
Black mole on
the palm or sole
of the foot:
High chance of
melanoma
Richard Scher, MD from the Dermatology Times, Feb.2003, p. 30.
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29
Melanoma and Estrogen
• Elevated estrogen
levels may be
implicated in
melanoma etiology
• Risk of melanoma
was higher for
patients who did not
receive anti-estrogens
Cherry
Angiomas
Ref: Cancer Prev Res. 2012. 5(1): 82-8.
Melanoma (dark colored)
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Prevent Skin
Cancer
• Avoid sun
exposure
• Extracts of Aloe,
Coptis,
Phellodendron
• Asparagus Extract
•
•
•
•
Sea Cucumber Ext
Bolbostemma Ext
Asparagus Extract
Reishi Spore
Extract
(organic folic acid)
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Extracts of Raphanus, Crataegus, Alisma, Garcinia
Removes ADP, Promotes the fat-burning process
to control weight
FOR BODILY
ACTIVITY
ENERGY
ADP + P
(INHIBITION)
FAT
Myxoma
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Skin Cancer
Protocol
• AGG (Antioxidant)
ATP
Squamous Cell
Carcinoma
DEGRADATION
Extracts of Raphanus, Crataegus,
Alisma, and Garcinia
 Extracts of Raphanus, Crataegus, Alisma,
Garcinia
 Tyrosine and Paeonia Extract
 Extracts of Cyperus, Curcuma, Astragalus
(for belly fat)
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• Removes fat by 51%
–If taken before meals
• Burns fat faster
–If taken before exercise
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Tyrosine and Paeonia Extracts
• Increases metabolic rate
• Increases serotonin and norepinephrine levels
• Induces a happy feeling, reducing cravings
for foods and promoting faster fat burning
Extracts of Cyperus, Curcuma,
Astragalus for belly fat
• Reduces abdominal fat by inhibiting aromatase
• The belly has the highest amount of aromatase
Exercise: Consume Energy (ATP)
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Copyright © 2012 Chi‟s Enterprise, Inc.
Reproduction of this work in any form, in whole or in part, by any means,
electronic or mechanical, including photocopying, microfilming, and recording,
or by any information storage and retrieval system, without permission in
writing from Chi‟s Enterprise is strictly prohibited at the risk of legal action.
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30