Annual Meeting Program - Society of Toxicology

Transcription

Contents
Sponsorship
2006 Annual Meeting Sponsors .........................Inside Front Cover
45th Annual Meeting & ToxExpo™
March 5–9, 2006
Program Overview ......................................................Front Foldout
Sponsorship Opportunities & The Toxicologist on CD-ROM
...................................................................... Inside Back Cover
Events and Maps
Career Resources and Development
Event Calendar by Day & Time ...................................................... 2
Career Resources and Development Services .................................... 34
Event Calendar by Event Name ..................................................... 7
San Diego Convention Center Map ............................................. 12
Social Functions
San Diego Hotel Accommodations .............................................. 14
Social Events ...................................................................................... 36
Downtown San Diego Map .......................................................... 15
Manchester Grand Hyatt San Diego Map .................................... 16
Award Winners
Marriott San Diego Hotel & Marina Map .................................... 18
2006 Award Winners ......................................................................... 37
San Diego Restaurants .................................................................. 20
2005 Student Award Winners ............................................................ 42
2006 ToxExpoTM
ToxExpo™ Exhibit Hall Floorplan................................................ 23
2006 Exhibitors ............................................................................. 24
Registration
Registration Information .............................................................. 26
General Information
45th Anniversary Raffle Contest .................................................... 27
Accessibility for Persons with Disabilities .................................... 27
Attire ............................................................................................. 27
Sessions Index
Scientific Sessions Index .................................................................... 43
Continuing Education
Continuing Education Courses ......................................................... 49
Program
Program Description .......................................................................... 57
Author Index.................................................................................... 257
Badges ........................................................................................... 27
Business Center ............................................................................. 27
Exhibit Hall (Hours/Location) ...................................................... 27
First Aid ......................................................................................... 27
Food Services ................................................................................. 27
Guest Hospitality Center and Program ........................................ 28
Housing Information and Reservations ....................................... 28
Internet Access and Electronic Devices ........................................ 29
Lost and Found ............................................................................. 29
Luggage Check .............................................................................. 29
Media Support Services ................................................................. 29
Memorabilia .................................................................................. 29
Message Center ............................................................................. 29
Photography Policy....................................................................... 30
Registration Desk Hours ............................................................... 30
Safety and Security........................................................................ 30
SOT Headquarters Office .............................................................. 30
Speaker Ready Room..................................................................... 30
Sponsorship................................................................................... 31
Transportation .............................................................................. 31
Tour Information .......................................................................... 32
The Toxicologist/Itinerary Planner ................................................. 32
Weather ......................................................................................... 32
SOT Leadership
2005–2006 Council .......................................................................... 280
Officers and Councilors ................................................................... 282
Past Presidents.................................................................................. 282
Elected Committees ......................................................................... 283
Appointed Committees ................................................................... 283
Officers—Specialty Sections ............................................................. 287
Officers—Regional Chapters ............................................................ 288
SOT References
SOT Award Descriptions and History .............................................. 289
Toxicology Specialists ...................................................................... 298
Headquarters Staff ........................................................................... 300
SOT Affiliates ................................................................................... 301
2007 Annual Meeting Session Proposal Information ..................... 312
San Diego
CALIFORNIA
45th Annual Meeting and ToxExpo
45th Annual
Meeting & ToxExpo
Calendar by Day &Time
Friday
Events are listed alphabetically by
the event start time.
March 3, 2006
EVENT CALENDAR
9:00 AM to 5:00 PM
HESI/SETAC In Vitro ADME
Bioaccumulation Workshop
Marriott Hotel & Marina
Columbia Room
(See page 57 in the Program Description
for Registration Information.)
Saturday
8:00 AM to 1:30 PM
Council Meeting
Manchester Room
9:00 AM to 5:00 PM
HESI/SETAC In Vitro ADME
Bioaccumulation Workshop
Columbia Room
See page 57 in the Program Description
for Registration Information.
11:30 AM to 6:00 PM
Johnson & Johnson Toxicology
Interest Group
Cardiff Room
March 4, 2006
1:00 PM to 6:00 PM
ABT Board of Directors Meeting
Del Mar Room
4:00 PM to 7:00 PM
SOT Office
San Diego Convention Center
Room 14A
5:30 PM to 8:30 PM
Education Fellowship Interviews
Room 12
2:00 PM to 5:00 PM
Committee Chair Orientation
Room 14B
4:00 PM to 7:00 PM
Speaker Ready Room
Room 14A
4:00 PM to 7:00 PM
Message Center/Housing Desk
Hall B Lobby
4:00 PM to 7:00 PM
Tour Desk
Hall A Lobby
(Hours are Subject to Change)
5:30 PM to 6:00 PM
Undergraduate Education
Program Orientation for Hosts,
Peer Mentors, and Advisors
Room 19
4:00 PM to 7:00 PM
Registration
Hall A Lobby
5:00 PM to 5:45 PM
Continuing Education Committee
Walk-Through
Room 5
Sunday
7:00 AM to 7:45 AM
Continuing Education Sunrise
Mini-Course (Ticket Required)
(See Signage for Room Location)
7:00 AM to 8:30 PM
Luggage Check
Hall B2 Lobby
7:00 AM to 5:00 PM
Hall B Lobby
7:00 AM to 8:00 PM
Registration
Hall A Lobby
7:00 AM to 5:30 PM
SOT Office
Room 14A
7:00 AM to 5:30 PM
Speaker Ready Room
Room 14A
7:00 AM to 5:00 PM
Tour Desk
Hall A Lobby
7:30 AM to 2:30 PM
Concession Stands
Hall A Lobby and Ballroom 6 Lobby
8:00 AM to 10:00 AM
CRAD Committee Meeting I
Oceanside Room
8:00 AM to 4:30 PM
Guest Hospitality Center
Manchester Room
As of January 1, 2006
6:15 PM to 9:00 PM
Undergraduate Education Program
Lecture & Reception
Room 16A
March 5, 2006
8:00 AM to 5:00 PM
ToxExpoTM Set Up
Exhibit Hall
8:00 AM to 5:00 PM
Undergraduate Education
Program Session
Room 16A
8:15 AM to 12:00 NOON
Continuing Education Courses
(Ticket Required)
(See Signage for Room Locations)
8:30 AM to 9:30 AM
IUTOX Enhancement of the
Appreciation and Image of
Toxicology Task Force Meeting
Encinitas Room
11:00 AM to 3:00 PM
Toxicological Sciences Associate
Editors Meeting
Cardiff Room
5:15 PM to 6:30 PM
Awards Ceremony Celebrating 45th
Anniverary (All Attendees Welcome)
Room 6C
11:45 AM to 1:15 PM
Continuing Education Luncheon for
Speakers, Committee, and Students
(By Invitation Only)
Room 4
6:30 PM to 7:30 PM
Welcoming Reception Celebrating
45th Anniversary
(All Attendees Welcome)
Sails Pavilion
12:00 NOON to 1:00 PM
IUTOX Science Commission Meeting
Encinitas Room
6:45 PM to 7:15 PM
Student Advisory Committee Meeting I
Room 14B
1:00 PM to 5:00 PM
IUTOX Executive Committee
Meeting I
Del Mar Room
7:00 PM to 8:00 PM
25–Year (or More) Member Reception
Celebrating 45th Anniversary
Room 4
9:00 AM to 11:30 AM
Toxicology Education Foundation
Trustees Meeting
Newport Beach Room
1:15 PM to 5:00 PM
(Ticket Required)
(See Signage for Room Locations)
9:30 AM to 11:30 AM
IUTOX Developing Countries
Committee Meeting
Encinitas Room
3:00 PM to 5:00 PM
Academic Program Session for
Undergraduate Students
Room 17B
10:00 AM to 3:30 PM
CRAD Job Bank Center
(Registration Only)
Leucadia Room
4:00 PM to 5:15 PM
Awards Recipients Photographed
Room 3
4:45 PM to 5:15 PM
Performance by San Diego
University Choral Scholars
Room 6C
10:00 AM to 5:00 PM
K–12 Committee Outreach Event—
Paracelsus Explores the Genome:
Toxicology Advances Health
San Diego Natural History Museum
(Public Invited—Free Admission for All)
Balboa Park
2
7:30 PM to 9:30 PM
LRRI Annual Reception for Employees
Manchester Room
7:30 PM to 8:30 PM
Student/Post-Doctoral Fellow Mixer
(All Students and Post-Docs are Invited
to Attend—Ticket Required)
Room 33
8:00 PM to 10:30 PM
Arizona Night
San Diego Ballroom A
8:00 PM to 10:00 PM
IUTOX Executive Committee Dinner
Top of the Market Restaurant
8:00 PM to 9:00 PM
Post-Doctoral Assembly Event
(All Post-Docs Invited)
Room 32
SOT's 45th Annual Meeting
45th Annual
Meeting & ToxExpo
Calendar by Day &Time (Continued)
6:15 AM to 7:30 AM
Comparative and Veterinary
Specialty Section Officers Breakfast
Room 4
6:30 AM to 8:00 AM
Regulatory Affairs and Legislative
Assistance Committee Meeting
Room 19
6:30 AM to 8:00 AM
Toxicological and Exploratory
Pathology Specialty Section Officer
Meeting
Room 17A
7:00 AM to 8:00 AM
American Board of Veterinary
Toxicology—Business Meeting
Newport Beach Room
7:00 AM to 8:30 AM
Continuing Education Committee
Meeting
Room 14B
7:00 AM to 8:30 AM
Immunotoxicology Specialty Section
Program Committee Meeting
Oceanside Room
7:00 AM to 8:30 PM
Luggage Check
Hall B2 Lobby
7:00 AM to 8:30 AM
Mechanisms Specialty Section
Officer Meeting
Room 9
7:00 AM to 5:00 PM
Hall B Lobby
7:00 AM to 8:30 AM
Past Presidents 45th Anniversary
Breakfast
Room 12
7:00 AM to 5:00 PM
Registration
Hall A Lobby
7:00 AM to 8:00 AM
Regulatory and Safety Evaluation
Specialty Section Officer Meeting
Room 11A
7:00 AM to 9:00 AM
Reproductive and Developmental
Specialty Section Officer Meeting
Room 15B
7:00 AM to 9:00 AM
Risk Assessment Specialty Section
Officer Meeting
Room 3
7:00 AM to 5:00 PM
SOT Office
Room 14A
March 6, 2006
7:00 AM to 5:00 PM
Speaker Ready Room
Room 14A
9:30 AM to 12:00 NOON
Scientific Sessions
(See Program Description for Room
Locations)
7:00 AM to 5:00 PM
Tour Desk
Hall A Lobby
9:30 AM to 4:30 PM
ToxExpoTM Exhibits Open
Exhibit Hall
7:30 AM to 2:30 PM
Concession Stands
Hall A Lobby and Room 6 Lobby
11:30 AM to 1:00 PM
Post-Doctoral Assembly Board
Meeting
Room 12
7:30 AM to 8:30 AM
Membership Committee Meeting
Room 10
12:00 NOON to 1:30 PM
45th Anniversary Raffle Contest
Exhibit Hall
7:30 AM to 8:30 AM
Program Committee Walk-Through
Room 5
12:00 NOON to 1:30 PM
Comparative and Veterinary
Specialty Section Meeting/Reception
Room 4
8:00 AM to 4:00 PM
Leucadia Room
12:00 NOON to 1:30 PM
Occupational and Public Health
Room 3
8:00 AM to 4:30 PM
Manchester Room
1:00 PM to 2:00 PM
IUTOX Communications
Commission Meeting
Encinitas Room
8:00 AM to 2:00 PM
Room 16B
1:30 PM to 4:30 PM
Poster Sessions
Exhibit Hall
8:30 AM to 9:15 AM
Plenary Lecture—Risk
Communication—The Perception
Gap, an Unrecognized Aspect of Risk
David Ropeik
Room 6
1:30 PM to 4:30 PM
Scientific Sessions
Locations)
9:00 AM to 9:30 AM
Poster Set Up
Exhibit Hall
1:30 PM to 2:30 PM
VIP ToxExpoTM Exhibit Hall
Walk-Through
Exhibit Hall
9:30 AM to 10:30 AM
Complimentary Coffee
(See signage in Exhibit Hall)
Exhibit Hall
4:30 PM to 6:00 PM
ABT Open Mixer Meeting
Rancho Las Palmas Room
9:30 AM to 2:30 PM
Concession Stands
(See Exhibit Hall map on page 23)
Exhibit Hall
4:30 PM to 6:00 PM
CRAD Seminar—Life After Your
Post-Doc: Advice on Finding
and Landing a Job
Room 2
9:30 AM to 4:30 PM
Internet Cafe
(See Exhibit Hall Map on page 23)
Exhibit Hall
4:30 PM to 6:00 PM
Environmental Health Perspectives
Editorial Board Meeting
Green Room
9:30 AM to 1:00 PM
IUTOX Executive Committee
Meeting II
Del Mar Room
4:30 PM to 6:00 PM
Roundtable and Sunset
Scientific Sessions
Locations)
9:30 AM to 11:15 AM
Poster Session for Visiting Students
Exhibit Hall
4:30 PM to 7:00 PM
Roundtable of Toxicology
Consultants Annual Meeting
Marina Ballroom G
9:30 AM to 12:00 NOON
Poster Sessions
Exhibit Hall
up-to-date information at www.toxicology.org
4:30 PM to 6:00 PM
Specialty Section Presidents Meeting
Room 14B
4:30 PM to 6:00 PM
Special Session—Using Animals
for Toxicological Research and
Testing: Best Practices for Assuring
Compliance with Animal Welfare
Regulations, Policies, and Guidelines
Room 1A
5:00 PM to 7:00 PM
Gulf Coast and South Central
Regional Chapters Joint Reception
Torrance Room
5:00 PM to 6:00 PM
Special Interest Group—American
Association of Chinese in Toxicology
Distinguished Chinese Toxicologist
Lecture
5:00 PM to 7:00 PM
Taylor and Francis Reception
Marina Ballroom F
5:30 PM to 8:00 PM
Special Interest Group—Korean
Toxicologists Association in America
Meeting/Reception
Columbia Rooms 1 & 2
6:00 PM to 7:30 PM
Carcinogenesis Specialty Section
Meeting/Reception
Room 10
6:00 PM to 7:30 PM
Drug Discovery Specialty Section
Meeting/Reception
Room 3
6:00 PM to 7:30 PM
Meeting/Reception
Room 4
6:00 PM to 8:00 PM
ITR Hospitality Reception
Cardiff Room
6:00 PM to 7:30 PM
Mechanisms Specialty Section
Meeting/Reception
Room 9
6:00 PM to 7:30 PM
Mixtures Specialty Section
Organizational Meeting/Reception
(All Invited to Plan Formation of
Section)
Room 15B
6:00 PM to 8:00 PM
Northern California and Pacific
Northwest Regional Chapters and
UC Davis Joint Meeting/Reception
San Diego Ballroom C
Continued on next page
3
EVENT CALENDAR
Monday
45th Annual
Meeting & ToxExpo
Monday (Continued)
EVENT CALENDAR
6:00 PM to 7:30 PM
Room 11A
6:00 PM to 8:00 PM
Special Interest Group—American
Association of Chinese in
Toxicology Meeting/Reception
March 6, 2006
6:00 PM to 8:00 PM
Special Interest Group—Association
of Scientists of Indian Origin in
America Meeting/Reception
Marina Ballroom E
6:30 PM to 8:30 PM
Neurobehavioral Teratology Society
Social
Balboa Room
7:15 PM to 8:30 PM
Specialty Section: Great Debate—
Human and Animal Testing: What is
Appropriate?
Room 11A
6:00 PM to 8:00 PM
St. Johns University 4th Annual
Toxicology Alumni Dinner
Newport Beach Room
Tuesday
6:50 AM to 8:00 AM
University of Louisiana at Monroe
TOX Breakfast
Cardiff Room
7:00 AM to 8:30 AM
Academy of Toxicological Sciences
Board Meeting
Carlsbad Room
7:00 AM to 8:30 AM
Food Safety Specialty Section
Officers Meeting
Room 4
7:00 AM to 8:00 AM
Gene Logic Toxicology Consultant
Workshop (By Invitation Only)
Torrance Room
7:00 AM to 8:00 PM
Luggage Check
Hall B2 Lobby
7:00 AM to 8:00 AM
Molecular Biology Specialty Section
Officer Meeting
Room 17A
7:00 AM to 9:00 AM
Neurotoxicology Specialty Section
Officers Meeting
Room 9
7:00 AM to 8:30 AM
Regional Chapter Presidents Meeting
Room 14B
7:00 AM to 4:00 PM
SOT Office
Room 14A
7:00 AM to 4:00 PM
Speaker Ready Room
Room 14A
7:00 AM to 8:30 AM
Student Advisory Committee
Meeting II
Room 12
7:00 AM to 8:00 AM
Women in Toxicology Specialty
Section Officers Meeting
Room 10
7:30 PM to 10:00 PM
Toxicological Sciences Dinner
Candelas Restaurant
9:00 PM to 11:00 PM
Michigan State University
Environmental Toxicology
Reception
Carlsbad Room
March 7, 2006
7:15 AM to 8:30 AM
Animals in Research Committee
Meeting
Room 19
8:30 AM to 4:30 PM
Internet Cafe
Exhibit Hall
7:30 AM to 9:30 AM
Concession Stands (Breakfast Items)
Hall A Lobby and Ballroom 6 Lobby
8:30 AM to 4:30 PM
Exhibit Hall
7:30 AM to 8:30 AM
In Vitro Specialty Section Officer
Meeting
Room 16A
9:00 AM to 12:00 NOON
Poster Sessions
Exhibit Hall
9:00 AM to 12:00 NOON
Scientific Sessions
Locations)
7:30 AM to 8:50 AM
Sunrise Scientific Session
Location)
11:30 AM to 1:00 PM
Education Committee Meeting
Room 12
11:30 AM to 1:00 PM
Telemetry in Toxicology: When is it
Appropriate? presented by Data
Sciences International
Marina Ballroom F
11:45 AM to 1:30 PM
WWW Advisory Committee Focus
Group Luncheon (By Invitation Only)
Room 16B
12:00 NOON to 1:30 PM
Exhibit Hall
8:00 AM to 4:00 PM
Leucadia Room
9:30 AM to 10:30 AM
Exhibit Hall
8:00 AM to 9:30 AM
Dermal Toxicology Specialty
Section Officers Meeting
Room 3
9:30 AM to 2:30 PM
Concession Stands
Exhibit Hall
8:00 AM to 4:30 PM
Manchester Room
9:45 AM to 10:45 AM
Informational Session—Contracting
Bioanalysis for Tox Studies and the
Evolution of the Costing Process
by CROs presented by SFBC
International
Room 11B
12:00 NOON to 1:15 PM
Student In Vitro Toxicology
Lecture and Luncheon
(Ticket Required)
Room 33
9:45 AM to 10:45 AM
Informational Session—The
Fundamentals of Toxicogenomics
presented by Gene Logic
Room 11A
12:00 NOON to 1:30 PM
Special Interest Group—Hispanic
Organization for Toxicologists
Meeting/Reception
Cardiff Room
10:00 AM to 11:30 AM
ToxLearn Work Group
Room 19
12:15 PM to 1:15 PM
Informational Sessions—HighContent Assays for In Vitro Toxicology
presented by Cellnomics, Inc.
Room 11A
8:00 AM to 8:50 AM
Medical Research Council
(MRC) Lecture—Cell Death and
Neurodegeneration
Dr. Junying Yuan
Room 6A
8:00 AM to 4:00 PM
Hall A Lobby
8:00 AM to 4:00 PM
Registration
Hall A Lobby
11:00 AM to 12:00 NOON
Informational Session—A Solution
for Toxicogenomics Analysis & Data
Management presented by Rosetta
Resolver® System
Room 11B
8:00 AM to 4:00 PM
Tour Desk
Hall A Lobby
8:30 AM to 9:30 AM
Informational Session—
Bioluminescent Methods for
ADME/Tox presented by Promega
Corporation
Room 11A
11:00 AM to 12:00 NOON
Understanding Your Pharmacological
Target Distribution Across Normal
and Diseased Human and Animal
Tissues presented by Gene Logic
Room 11A
4
12:00 NOON to 1:00 PM
In Vitro Systems for the Assessment
of Toxicology
Marina Ballroom D
12:00 NOON to 1:30 PM
Issues Session—Safety Assessment of
the Major Human Metabolites
Room 6F
12:15 PM to 1:15 PM
Toxicogenomics Solutions Using
Illumina’s BeadArray Technology
presented by Illumina
Room 11B
45th Annual
Meeting & ToxExpo
1:30 PM to 2:30 PM
Informational Session—GeneChip®
Microarrays and Their Use In
Toxicogenomics: Part One presented
by Affymetrix
Room 11A
2:45 PM to 3:45 PM
Informational Session—Applications
of GeneChip® Technology for
Toxicogenomics: Part Two presented
by Affymetrix
Room 11A
1:30 PM to 2:30 PM
Informational Session—New and Novel
Biomarkers in Nephrotoxicity Testing
presented by Biotrin International
Room 11B
2:45 PM to 3:45 PM
Informational Session—Expert
Services and Custom Solutions
presented by Dow Corning
Room 11B
1:30 PM to 4:30 PM
Poster Sessions
Exhibit Hall
4:30 PM to 6:00 PM
SOT Annual Business Meeting
45th Anniversary
(SOT Members Only)
Room 5B
1:30 PM to 4:30 PM
Scientific Sessions
Locations)
2:00 PM to 3:30 PM
Meeting with Dr. Kenneth Olden for
Students/Post-Doctoral Fellows to
Discuss NIEHS Research Opportunities
(All Students Invited)
Room 16A
March 7, 2006
6:00 PM to 9:00 PM
GLKK Toxicogenomics Seminar
6:00 PM to 7:30 PM
In Vitro Specialty Section Meeting/
Reception
Room 9
6:00 PM to 7:30 PM
Metals Specialty Section Meeting/
Reception
Room 3
6:00 PM to 7:30 PM
Meeting/Reception
Room 17A
4:45 PM to 6:00 PM
ToxExpoTM 2007 Exhibit Space
Selection Meeting
Room 11A
6:00 PM to 8:00 PM
Northeast Regional Chapter
Reception
Cardiff Room
5:00 PM to 7:00 PM
Southern California and Mountain
West Joint Reception
Rama Restaurant
6:00 PM to 7:30 PM
Reproductive and Developmental
Room 15B
6:00 PM to 7:30 PM
Food Safety Specialty Section
Meeting/Reception
Room 4
Wednesday
7:00 AM to 8:30 AM
Committee on Diversity Initiatives
Meeting
Room 19
7:00 AM to 8:00 PM
Luggage Check
Hall B2 Lobby
7:00 AM to 8:30 AM
Midwest Regional Chapter Members
Breakfast Meeting
7:00 AM to 4:00 PM
SOT Office
Room 14A
7:00 AM to 4:00 PM
Speaker Ready Room
Room 14A
7:00 AM to 8:30 AM
Technical Committee Meeting of the
Inhalation Specialty Section
Room 3
7:00 AM to 8:30 AM
WWW Advisory Committee Meeting
Room 12
6:00 PM to 8:30 PM
Special Interest Group—African
Society of Toxicological Sciences
Symposium/Meeting/Reception
Marina Ballroom D
6:00 PM to 7:30 PM
Toxicologic and Exploratory
Pathology Specialty Section
Meeting/Reception
Room 16A
6:00 PM to 7:30 PM
Section Meeting/Reception
Room 10
6:30 PM to 7:30 PM
International Neurotoxicology
Association Business Meeting
Green Room
7:30 PM to 10:00 PM
University of Rochester Toxicology
Alumni Reception
Manchester Room
9:00 PM to 11:00 PM
Rutgers University Joint Graduate
Program in Toxicology Annual
Dessert Reception
Marina Ballroom E
March 8, 2006
7:30 AM to 9:30 AM
Concession Stands (Breakfast Items)
Hall A Lobby
8:30 AM to 9:30 AM
Informational Session—Cardiac
Safety—Current Thinking When
Approaching Safety Assessment
Studies presented by Covance
Room 11B
7:30 AM to 8:30 AM
Special Interest Group Task Force
Meeting
Room 9
8:30 AM to 9:30 AM
Informational Session—Morpholino
Antisense Oligos for Blocking
Translation and Modifying Splicing
presented by Gene Tools
Room 11A
8:00 AM to 4:00 PM
Leucadia Room
8:00 AM to 4:30 PM
Manchester Room
8:30 AM to 4:30 PM
Internet Cafe
Exhibit Hall
8:00 AM to 4:00 PM
Hall B Lobby
8:30 AM to 4:30 PM
Exhibit Hall
8:00 AM to 4:00 PM
Registration
Hall A Lobby
9:00 AM to 10:30 AM
Exhibit Hall
8:00 AM to 8:50 AM
SOT/EUROTOX Debate: ‘Omics’
Research Does Not Add Substantially
to the Safety Assessment of Chemicals
Room 6A
9:00 AM to 12:00 NOON
Poster Sessions
Exhibit Hall
8:00 AM to 4:00 PM
Tour Desk
Hall A Lobby
9:00 AM to 12:00 NOON
Scientific Sessions
(See Program Descriptions for Room
Locations)
9:30 AM to 2:30 PM
Concession Stands
Exhibit Hall
9:45 AM to 10:45 AM
Informational Session—Create
Bibliographies Instantly with
EndNote and Discover New
Reference Tools presented by
Thomson ResearchSoft
Room 11A
9:45 AM to 10:45 AM
Informational Session—Expanding
Role of Telemetry in Toxicology
presented by Data Sciences
International
Room 11B
11:00 AM to 12:00 NOON
Informational Session—Integration
of In-Life Parameters with
Toxicogenomics presented by
Gene Logic, Inc.
Room 11A
11:00 AM to 12:00 NOON
Informational Session—The Future
of Hematopoietic Testing presented
by StemCell Technologies, Inc.
Room 11B
11:30 AM to 1:30 PM
Committee for K–12 Education
Meeting
Room 12
5
EVENT CALENDAR
Tuesday (Continued)
45th Annual
Meeting & ToxExpo
Calendar by Day &Time
(Continued)
Wednesday (Continued)
EVENT CALENDAR
11:30 AM to 1:30 PM
Finance Committee Meeting
Room 19
12:00 NOON to 1:30 PM
Exhibit Hall
12:00 NOON to 1:30 PM
Special Session—Meet the Directors:
Update of Activities at Government
Agencies
Room 6D
12:15 PM to 1:15 PM
Informational Session—Advances
in Integrated Microarray Analysis
presented by Agilent
Room 11A
1:30 PM to 2:30 PM
Informational Session—Novel BD
GentestTM ADME/Tox Technologies
for Metabolism and Toxicity
presented by BD Biosciences
Room 11B
March 8, 2006
1:30 PM to 2:30 PM
Informational Session—Using
Histological Evaluation to Enhance
the Bovine Cornea Opacity and
Permeability (BCOP) Assay for Ocular
Irritation presented by Institute for In
Vitro Sciences
Room 11A
1:30 PM to 4:30 PM
Poster Sessions
Exhibit Hall
1:30 PM to 4:30 PM
Scientific Sessions
Locations)
2:00 PM to 4:00 PM
Exhibit Liaison Committee Meeting
Room 12
2:30 PM to 4:30 PM
Board of Publications Committee
Meeting
Room 19
7:00 AM to 11:30 AM
SOT Office
Room 14A
7:00 AM to 11:30 AM
Speaker Ready Room
Room 14A
4:30 PM to 6:00 PM
Special Session—Town Hall
Meeting: Recent Changes in
Participation Requirements on
Government Advisory Groups/
Panels
Room 6F
6:00 PM to 7:30 PM
Inhalation Specialty Section
Meeting/Reception
Room 3
6:00 PM to 9:00 PM
Academy of Toxicological Sciences
Dinner
Columbia Room
6:00 PM to 7:30 PM
Meeting/Reception
Room 9
6:00 PM to 7:30 PM
Meeting/Reception
Room 16A
7:00 PM to 8:30 PM
President’s Reception
Bayside Room
8:00 AM to 8:50 AM
Historical Highlight Session—
Organophosphates from Nerve to
Gas to Insecticide
Room 7B
8:00 AM to 11:30 AM
Hall B Lobby
8:00 AM to 11:30 AM
Registration
Hall A Lobby
8:00 AM to 11:30 AM
Tour Desk
Hall A Lobby
7:30 AM to 9:30 AM
CRAD Committee Meeting II
Oceanside Room
9:00 AM to 12:00 NOON
Poster Sessions
Room 6
7:30 AM to 8:30 AM
Room 19
9:00 AM to 12:00 NOON
Scientific Sessions
Locations)
8:00 AM to 11:30 AM
Manchester Room
6:00 PM to 7:30 PM
Dermal Toxicology Specialty
Room 4
March 9, 2006
7:30 AM to 12:00 NOON
Concession Stands
Hall A Lobby
8:00 AM to 12:00 NOON
(Message Center Only)
Solana Room
4:30 PM to 5:20 PM
Special Session—Merit Awardee
Lecture
Room 15A
5:15 PM to 6:00 PM
Council Meeting with Executive
Board of Student Advisory
Committee and Post-Doctoral
Assembly
Room 12
Thursday
7:00 AM to 1:00 PM
Luggage Check
Hall B2 Lobby
6:00 PM to 7:30 PM
Biological Modeling Specialty
Room 10
4:45 PM to 5:15 PM
Council Meeting with Students/PostDoctoral Fellows
Room 15B
4:30 PM to 6:00 PM
Grantsmanship Forum: Sources for
Funding Support
Room 6E
4:30 PM to 6:00 PM
Roundtable and Scientific Sessions
Locations)
9:00 AM to 12:00 NOON
Special Session—Hurricane Katrina:
Interface Between Response and
Research
Room 6E
6
45th Annual
Meeting & ToxExpo
Calendar by Event Name
DATE:
TIME:
LOCATION:
ROOM:
25-Year (or More) Member Reception
Celebrating 45th Anniversary (By Invitation Only)
Sun, March 5
7:00 PM to 8:00 PM
Room 4
45th Anniversary Raffle Contest
Mon, March 6
12:00 NOON to 1:30 PM
Exhibit Hall
Tue, March 7
12:00 NOON to 1:30 PM
Exhibit Hall
Wed, March 8
12:00 NOON to 1:30 PM
Exhibit Hall
A Solution for Data Toxicogenenomics Analysis
& Management presented by Rosetta Resolver
System (Informational Session)
Tue, March 7
11:00 AM to 12:00 NOON
Room 11B
ABT Board of Directors Meeting
Sat, March 4
1:00 PM to 6:00 PM
Del Mar Room
ABT Open Mixer Meeting
Mon, March 6
4:30 PM to 6:00 PM
Rancho Las
Palmas Room
Academic Program Session for Undergraduate
Students
Sun, March 5
3:00 PM to 5:00 PM
Room 17B
Academy of Toxicological Sciences Board
Meeting
Tue, March 7
7:00 AM to 8:30 AM
Carlsbad Room
Academy of Toxicological Sciences Dinner
Wed, March 8
6:00 PM to 9:00 PM
Columbia Room
Advances in Integrated
Microarray Analysis presented
by Agilent (Informational Session)
Wed, March 8
12:15 PM to 1:15 PM
Room 11A
African Society of Toxicological
Sciences Symposium Meeting/Reception
(Special Interest Group)
Tue, March 7
6:00 PM to 8:30 PM
Marina
Ballroom D
American Association of Chinese in Toxicology:
Distinguished Chinese Toxicologist Lecture
Mon, March 6
5:00 PM to 6:00 PM
San Diego
Ballroom A
American Association of Chinese in Toxicology
Meeting/Reception (Special Interest Group)
Mon, March 6
6:00 PM to 8:00 PM
San Diego
Ballroom A
American Board of Veterinary Toxicology
Business Meeting
Mon, March 6
7:00 AM to 8:00 AM
Newport Beach
Room
Animals in Research Committee Meeting
Tue, March 7
7:15 AM to 8:30 AM
Room 19
Annual Business Meeting (SOT Members Only)
Tue, March 7
4:30 PM to 6:00 PM
Room 5B
Applications of GeneChip Technology for
Toxicogenomics: Part Two presented by
Affymetrix (Informational Session)
Tue, March 7
2:45 PM to 3:45 PM
Room 11A
Arizona Night
Sun, March 5
8:00 PM to 10:30 PM
San Diego
Ballroom A
Association of Scientists of Indian Origin in
America Meeting/Reception ( Special Interest Group)
Mon, March 6
6:00 PM to 8:00 PM
Marina Ballroom E
Awards Ceremony Celebrating 45th Anniversary
Sun, March 5
5:15 PM to 6:30 PM
Room 6C
Awards Recipients Photographed
Sun, March 5
4:00 PM to 5:15 PM
Room 3
Biological Modeling Specialty Section
Meeting/Reception
Wed, March 8
6:00 PM to 7:30 PM
Room 10
8:30 AM to 9:30 AM
Room 11A
Bioluminescent Methods for ADME/Tox presented Tue, March 7
by Promega Corporation (Informational Session)
Board of Publications Committee Meeting
Wed, March 8
2:30 PM to 4:30 PM
Room 19
Carcinogenesis Specialty Section Meeting/Reception Mon, March 6
6:00 PM to 7:30 PM
Room 10
Cardiac Safety—Current Thinking When
Approaching Safety Assessment Studies
presented by Covance (Informational Session)
Wed, March 8
8:30 AM to 9:30 AM
Room 11B
Career Resource & Development Committee
Meeting I
Sun, March 5
8:00 AM to 10:00 AM
Oceanside Room
Career Resource and Development Committee
Meeting II
Thu, March 9
7:30 AM to 9:30 AM
Oceanside Room
Career Resource and Development Seminar—
Life After Your Post-Doc: Advice on Finding
and Landing a Job
Mon, March 6
4:30 PM to 6:00 PM
Room 2
Continuing Education Luncheon for Speakers,
Committee, and Students (By Invitation Only)
Sun, March 5
11:45 AM to 1:15 PM
Room 4
Committee Chair Orientation
Sat, March 4
2:00 PM to 5:00 PM
Room 14B
Committee for K–12 Education Meeting
Wed, March 8
11:30 AM to 1:30 PM
Room 12
Committee on Diversity Initiatives Meeting
Wed, March 8
7:00 AM to 8:30 AM
Room 19
Comparative and Veterinary Specialty Section
Meeting/Reception
Mon, March 6
12:00 NOON to 1:30 PM
Room 4
7
EVENT CALENDAR
Refer to the Scientific Index on page 43 for Scientific Session details.
EVENT:
45th Annual
Meeting & ToxExpo
Calendar by Event Name (Continued)
EVENT CALENDAR
EVENT:
DATE:
TIME:
LOCATION:
ROOM:
Comparative and Veterinary Specialty Section
Officers Breakfast
Mon, March 6
6:15 AM to 7:30 AM
Room 4
Continuing Education Committee Meeting
Mon, March 6
7:00 AM to 8:30 AM
Room 14B
Continuing Education Courses AM
(Ticket Required)
Sun, March 5
1:15 PM to 5:00 PM
See Signage for Room
Locations
Continuing Education Courses PM
(Ticket Required)
Sun, March 5
8:15 PM to 12:00 NOON
Locations
Continuing Education Sunrise Mini-Course
(Ticket Required)
Sun, March 5
7:00 AM to 7:45 AM
Locations
Continuing Education Committee Walk-Through
Sat, March 4
5:00 PM to 5:45 PM
Room 5
Contracting Bioanalysis for Tox Studies and the
Evolution of the Costing Process by CRO’s
presented by SFBC International
(Informational Session)
Tue, March 7
9:45 AM to 10:45 AM
Room 11B
Council Meeting
Sat, March 4
8:00 AM to 1:30 PM
Manchester Room
Council Meeting with Executive Board of Student
Advisory Committee and Post-Doctoral Assembly
Wed, March 8
5:15 PM to 6:00 PM
Room 12
Council Meeting with Students/Post-Doctoral
Fellows
Wed, March 8
4:45 PM to 5:15 PM
Room 15B
Create Bibliographies Instantly with EndNote
and Discover New Reference Tools presented
by Thomson ResearchSoft (Informational Session)
Wed, March 8
9:45 AM to 10:45 AM
Room 11A
Dermal Toxicology Specialty Section
Meeting/Reception
Wed, March 8
6:00 PM to 7:30 PM
Room 4
Dermal Toxicology Specialty Section
Officers Meeting
Tue, March 7
8:00 AM to 9:30 AM
Room 3
Drug Discovery Specialty Section
Meeting/Reception
Mon, March 6
6:00 PM to 7:30 PM
Room 3
Education Committee Meeting
Tue, March 7
11:30 AM to 1:00 PM
Room 12
Education Fellowship Interviews
Sat, March 4
5:30 PM to 8:30 PM
Room 12
Environmental Health Perspectives Editorial
Board Meeting
Mon, March 6
4:30 PM to 6:00 PM
Green Room
EUROTOX/SOT Debate—’Omics’ Research Does
Not Add Substantially to the Safety Assessment of
Chemicals
Wed, March 8
8:00 AM to 8:50 AM
Room 6A
Exhibit Liaison Committee Meeting
Wed, March 8
2:00 PM to 4:00 PM
Room 12
Expanding Role of Telemetry in Toxicology
presented by Data Sciences International
Wed, March 8
9:45 AM to 10:45 AM
Room 11B
Expert Services and Custom Solutions presented
by Dow Corning (Informational Session)
Tue, March 7
2:45 PM to 3:45 PM
Room 11B
Finance Committee Meeting
Wed, March 8
11:30 AM to 1:30 PM
Room 19
Food Safety Specialty Section Meeting/Reception
Tue, March 7
6:00 PM to 7:30 PM
Room 4
Food Safety Specialty Section Officers Meeting
Tue, March 7
7:00 AM to 8:30 AM
Room 4
Fundamentals of Toxicogenomics presented by
Gene Logic (Informational Session)
Tue, March 7
9:45 AM to 10:45 AM
Room 11A
Future of Hematopoietic Testing presented
by StemCell Technologies, Inc.
Wed, March 8
11:00 AM to 12:00 NOON
Room 11B
Gene Logic Toxicology Consultant
Workshop (By Invitation Only)
Tue, March 7
7:00 AM to 8:00 AM
Torrance Room
GeneChip Microarrays and their Use in
Toxicogenomics: Part One presented by
Affymetrix
Tue, March 7
1:30 PM to 2:30 PM
Room 11A
GLKK Toxicogenomics Seminar (By Invitation Only)
Tue, March 7
6:00 PM to 9:00 PM
Rancho Las Palmas
Room
Grantsmanship Forum—Sources for Funding
Support
Wed, March 8
4:30 PM to 6:00 PM
Room 6E
Gulf Coast and South Central Joint Reception
Mon, March 6
5:00 PM to 7:00 PM
Torrance Room
HESI/SETAC In Vitro ADME Bioaccumulation
Workshop (Registration Required)
Fri, March 3
9:00 AM to 5:00 PM
Columbia Room
HESI/SETAC In Vitro ADME Bioaccumulation
Workshop (Registration Required)
Sat, March 4
9:00 AM to 5:00 PM
Columbia Room
8
45th Annual
Meeting & ToxExpo
EVENT:
TIME:
LOCATION:
ROOM:
High Content Assays for In Vitro Toxicology
Tue, March 7
presented by Cellnomics, Inc. (Informational Session)
DATE:
12:15 PM to 1:15 PM
Room 11A
Hispanic Organization for Toxicologists
Tue, March 7
12:00 NOON to 1:30 PM
Cardiff Room
Hurricane Katrina: Interface Between Response
and Research Special Session
Thu, March 9
9:00 AM to 12:00 NOON
Room 6E
Meeting/Reception
Mon, March 6
6:00 PM to 7:30 PM
Room 4
Immunotoxicology Specialty Section Program
Committee Meeting
Mon, March 6
7:00 AM to 8:30 AM
Oceanside Room
In Vitro Specialty Section Meeting/Reception
Tue, March 7
6:00 PM to 7:30 PM
Room 9
In Vitro Specialty Section Officers Meeting
Tue, March 7
7:30 AM to 8:30 AM
Room 16A
In Vitro Systems for the Assessment of Toxicology
Tue, March 7
12:00 NOON to 1:00 PM
Marina Ballroom D
Inhalation Specialty Section Meeting/Reception
Wed, March 8
6:00 PM to 7:30 PM
Room 3
Integration of In-Life Parameters with
Toxicogenomics presented by Gene Logic
Wed, March 8
11:00 AM to 12:00 NOON
Room 11A
International Neurotoxicology Association
Business Meeting
Tue, March 7
6:30 PM to 7:30 PM
Green Room
Issues Session—Safety Assessment of the Major
Human Metabolities
Tue, March 7
12:00 NOON to 1:30 PM
Room 6F
ITR Hospitality Reception
Mon, March 6
6:00 PM to 8:00 PM
Cardiff Room
IUTOX Communications Commission Meeting
Mon, March 6
1:00 PM to 2:00 PM
Encinitas Room
IUTOX Developing Countries Committee Meeting
Sun, March 5
9:30 AM to 11:30 AM
Encinitas Room
IUTOX Enhancement of the Appreciation and
Image of Toxicology Task Force Meeting
Sun, March 5
8:30 AM to 9:30 AM
Encinitas Room
IUTOX Executive Committee Dinner
Sun, March 5
8:00 PM to 10:00 PM
Top of the Market Restaurant
750 N. Harbor Drive
IUTOX Executive Committee Meeting I
Sun, March 5
1:00 PM to 5:00 PM
Del Mar Room
IUTOX Executive Committee Meeting II
Mon, March 6
9:30 AM to 1:00 PM
Del Mar Room
IUTOX Science Commission Meeting
Sun, March 5
12:00 NOON to 1:00 PM
Encinitas Room
Johnson & Johnson Toxicology Interest Group
Sat, March 4
11:30 AM to 6:00 PM
Cardiff Room
K–12 Committee Outreach Event—Paracelus
Explores the Genome: Toxicology Advances
Health (Free Admission for All)
Sun, March 5
10:00 AM to 5:00 PM
Natural History Museum
Balboa Park
Korean Toxicologist Association in America
Mon, March 6
5:30 PM to 8:00 PM
Columbia Rooms
1&2
LRRI Annual Reception for Employees
Sun, March 5
7:30 PM to 9:30 PM
Manchester Room
Mechanisms Specialty Section Meeting/Reception
Mon, March 6
6:00 PM to 7:30 PM
Room 9
Mechanisms Specialty Section Officers Meeting
Mon, March 6
7:00 AM to 8:30 AM
Room 9
Meet the Directors Session: Update of Activities
of Selected Government Agencies
Wed, March 8
12:00 NOON to 1:30 PM
Room 6D
Meeting with Dr. Kenneth Olden for Students/
Post-Doctoral Fellows
Tue, March 7
2:00 PM to 3:30 PM
Room 16A
Membership Committee Meeting
Mon, March 6
7:30 AM to 8:30 AM
Room 10
Merit Awardee Lecture
Wed, March 8
4:30 PM to 5:20 PM
Room 15A
Metals Specialty Section Meeting/Reception
Tue, March 7
6:00 PM to 7:30 PM
Room 3
Michigan State University Environmental
Toxicology Reception
Midwest Regional Chapter Members Breakfast
Meeting
Mon, March 6
9:00 PM to 11:00 PM
Carlsbad Room
Wed, March 8
7:00 AM to 8:30 AM
Rancho Las Palmas
Room
Mixtures Specialty Section Organizational
Meeting/Reception
Mon, March 6
6:00 PM to 7:30 PM
Room 15B
Meeting/Reception
Tue, March 7
6:00 PM to 7:30 PM
Room 17A
Molecular Biology Specialty Section Officers Meeting
Tue, March 7
7:00 AM to 8:00 AM
Room 17A
Morpholino Antisense Oligos for Blocking
Translation and Modifying Splicing presented by
Gene Tools (Informational Session)
Wed, March 8
8:30 AM to 9:30 AM
Room 11A
MRC Lecture: Cell Death and Neurodegeneration
Tue, March 7
8:00 AM to 8:50 AM
Room 6A
Neurobehavioral Teratology Society Social
Mon, March 6
6:30 PM to 8:30 PM
Balboa Room
9
EVENT CALENDAR
45th Annual
Meeting & ToxExpo
EVENT CALENDAR
EVENT:
DATE:
TIME:
LOCATION:
ROOM:
Meeting/Reception
Wed, March 8
6:00 PM to 7:30 PM
Room 9
Neurotoxicology Specialty Section Officers Meeting Tue, March 7
7:00 AM to 9:00 AM
Room 9
New and Novel Biomarkers in Nephrotoxicity
Testing Presented by Biotrin International
Tue, March 7
1:30 PM to 2:30 PM
Room 11B
Northeast Regional Chapter Reception
Tue, March 7
6:00 PM to 8:00 PM
Cardiff Room
Northern California and Pacific Northwest Regional Mon, March 6
Chapters and UC Davis Joint Reception
6:00 PM to 8:00 PM
San Diego Ballroom C
Novel BD Gentest ADME/Tox Technologies for
Metabolism and Toxicity presented by BD
Biosciences (Informational Session)
Wed, March 8
1:30 PM to 2:30 PM
Room 11B
Occupational and Public Health Specialty Section
Meeting/Reception
Mon, March 6
12:00 NOON to 1:30 PM
Room 3
Past Presidents 45th Anniversary Breakfast
Mon, March 6
7:00 AM to 8:30 AM
Room 12
Performance by San Diego Choral Scholars
Sun, March 5
4:45 PM to 5:15 PM
Room 6C
Plenary Lecture: Risk Communication—
Mon, March 6
The Perception Gap, an Unrecognized Aspect of Risk
8:30 AM to 9:15 AM
Room 6
Post-Doctoral Assembly Board Meeting
Mon, March 6
11:30 AM to 1:00 PM
Room 12
Post-Doctoral Assembly Event
Sun, March 5
8:00 PM to 9:00 PM
Room 32
Poster Session for Visiting Students
Mon, March 6
9:30 AM to 11:15 AM
Exhibit Hall
Poster Sessions
Mon, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
Poster Sessions
Mon, March 6
1:30 PM to 4:30 PM
Exhibit Hall
Poster Sessions
Tue, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
Poster Sessions
Tue, March 7
1:30 PM to 4:30 PM
Exhibit Hall
Poster Sessions
Wed, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
Poster Sessions
Wed, March 8
1:30 PM to 4:30 PM
Exhibit Hall
Poster Sessions
Thu, March 9
9:00 AM to 12:00 NOON
Room 6
President’s Reception (By Invitation Only)
Wed, March 8
7:00 PM to 8:30 PM
Bayside Room
Thu, March 9
7:30 AM to 8:30 AM
Room 19
Program Committee Walk-Through
Mon, March 6
7:30 AM to 8:30 AM
Room 5
Regional Chapter Presidents Meeting
Tue, March 7
7:00 AM to 8:30 AM
Room 14B
Regulatory Affairs and Legislative Assistance
Committee Meeting
Mon, March 6
6:30 AM to 8:00 AM
Room 19
Regulatory and Safety Evaluation Specialty
Section: Great Debate—Human and
Animal Testing: What’s Appropriate?
Mon, March 6
7:15 PM to 8:30 PM
Room 11A
Mon, March 6
6:00 PM to 7:30 PM
Room 11A
Section Officer Meeting
Mon, March 6
7:00 AM to 8:00 AM
Room 11A
Reproductive and Developmental Specialty
Section Officer Meeting
Mon, March 6
7:00 AM to 9:00 AM
Room 15B
Reproductive and Developmental Specialty
Tue, March 7
6:00 PM to 7:30 PM
Room 15B
Meeting/Reception
Wed, March 8
6:00 PM to 7:30 PM
Room 16A
Risk Assessment Specialty Section Officers Meeting Mon, March 6
7:00 AM to 9:00 AM
Room 3
Roundtable of Toxicology Consultants
Annual Meeting
Mon, March 6
4:30 PM to 7:00 PM
Marina Ballroom G
Rutgers University Joint Graduate Program in
Toxicology Annual Dessert Reception
Tue, March 7
9:00 PM to 11:00 PM
Marina Ballroom E
San Diego University Choral Scholars Performance Sun, March 5
4:45 PM to 5:15 PM
Room 6C
SOT/EUROTOX Debate—’Omics’ Research Does
Not Add Substantially to the Safety Assessment
of Chemicals
Wed, March 8
8:00 AM to 8:50 AM
Room 6A
Southern California and Mountain West Joint
Reception
Tue, March 7
5:00 PM to 7:00 PM
Columbia Room
Special Interest Group Task Force Meeting
Wed, March 8
7:30 AM to 8:30 AM
Room 9
10
45th Annual
Meeting & ToxExpo
EVENT:
DATE:
TIME:
LOCATION:
ROOM:
Specialty Section Presidents Meeting
Mon, March 6
4:30 PM to 6:00 PM
Room 14B
St. Johns University 4th Annual Toxicology
Alumni Dinner
Mon, March 6
6:00 PM to 8:00 PM
Newport Beach Room
Student Advisory Committee Meeting I
Sun, March 5
6:45 PM to 7:15 PM
Room 14B
Student Advisory Committee Meeting II
Tue, March 7
7:00 AM to 8:30 AM
Room 12
Student In Vitro Toxicology Lecture & Luncheon
(Ticket Required)
Tue, March 7
12:00 NOON to 1:15 PM
Room 33
Student/Post-Doctoral Fellow Mixer
(Ticket Required)
Sun, March 5
7:30 PM to 8:30 PM
Room 33
Taylor and Francis Reception
Mon, March 6
5:00 PM to 7:00 PM
Marina Ballroom F
Technical Committee Meeting of the Inhalation
Specialty Section
Wed, March 8
7:00 AM to 8:30 AM
Room 3
Telemetry in Toxicology: When is it Appropriate?
presented by Data Sciences International
Tue, March 7
11:30 AM to 1:00 PM
Marina Ballroom F
Town Hall Meeting Session—Recent Changes in
Participation Requirements on Government
Advisory Groups/Panels
Wed, March 8
4:30 PM to 6:00 PM
Room 6F
ToxExpoTM 2007 Exhibit Space Selection Meeting
Tue, March 7
4:45 PM to 6:00 PM
Room 11A
Toxicogenomics Solutions Using Illumina’s
BeadArray Technology presented by Illumina
Tue, March 7
12:15 PM to 1:15 PM
Room 11B
Toxicologic and Exploratory Pathology Specialty
Tue, March 7
6:00 PM to 7:30 PM
Room 16A
Toxicologic and Exploratory Pathology Specialty
Section Officers Meeting
Mon, March 6
6:30 AM to 8:00 AM
Room 17A
Toxicological Sciences Associate Editors Meeting
Sun, March 5
11:00 AM to 3:00 PM
Cardiff Room
Toxicological Sciences Dinner (By Invitation Only)
Mon, March 6
7:30 PM to 10:00 PM
Candelas Restaurant
416 3rd Avenue
Toxicology Education Foundation Trustees
Meeting
Sun, March 5
9:00 AM to 11:30 AM
Newport Beach Room
ToxLearn Work Group
Tue, March 7
10:00 AM to 11:30 AM
Room 19
Undergraduate Education Program—
Lecture/Reception
Sat, March 4
6:15 PM to 8:45 PM
Room 16A
Orientation for Hosts, Peer Mentors and
Advisors
Sat, March 4
5:30 PM to 6:00 PM
Room 19
Sun, March 5
8:00 AM to 5:00 PM
Room 16A
Mon, March 6
8:00 AM to 2:00 PM
Room 16B
Understanding Your Pharmacological Target
Distribution Across Normal and Diseased
Human and Animal Tissues presented by
Gene Logic (Informational Session)
Tue, March 7
11:00 AM to 12:00 NOON
Room 11A
University of Louisiana TOX Breakfast
Tue, March 7
6:50 AM to 8:00 AM
Cardiff Room
University of Rochester Toxicology Alumni
Reception
Tue, March 7
7:30 PM to 10:00 PM
Manchester Room
Using Animals for Toxicological Research
and Testing (Special Session)
Mon, March 6
4:30 PM to 6:00 PM
Room 1A
Using Histological Evaluation to Enhance
the Bovine Cornea Opacity and Permeability
(BCOP) Assay for Ocular Irritation presented
by Institute for In Vitro Sciences
Wed, March 8
1:30 PM to 2:30 PM
Room 11A
VIP ToxExpoTM Exhibit Hall Walk-Through
Mon, March 6
1:30 PM to 2:30 PM
Exhibit Hall
Welcoming Reception
Celebrating 45th Anniversary
Sun, March 5
6:30 PM to 7:30 PM
Sails Pavilion
Section Officers Meeting
Tue, March 7
7:00 AM to 8:00 AM
Room 10
Women in Toxicology Specialty Section
Meeting/Reception
Tue, March 7
6:00 PM to 7:30 PM
Room 10
WWW Advisory Committee Focus Group
Luncheon (By Invitation Only)
Tue, March 7
11:45 AM to 1:30 PM
Room 16B
WWW Advisory Committee Meeting
Wed, March 8
7:00 AM to 8:30 AM
Room 12
11
EVENT CALENDAR
12
Across from Exhibit Hall D
W
E
S
2007 Annual Meeting:
Charlotte Convention
Center and Visitors Bureau
Memorabilia Booth
(Sunday)
CE Booth
Restrooms
1A
Registration is located on the
Ground Level (see page 13)
Restrooms
Upper Level
Business Center
(Ground Level)
N
Sails Pavilion
FedexKinkos
Rooms 33–34
MAPS
Restrooms
45th Annual
Meeting & ToxExpo
45th Annual
Meeting & ToxExpo
Mezzanine Level
SOT Office/
Speaker Ready
Room
Restrooms
Restrooms
S
E
W
Security (upstairs)
Ground Level
More detailed map of
Exhibit Hall on page 23.
MAPS
ToxExpoTM
Exhibit Hall
Below
N
ToxExpoTM Show
Management
Office and First Aid
(upstairs)
Restrooms
Restrooms
Restrooms
A
Exhibit Hall
B1
Marriott
Hotel &
Marina
ToxExpoTM
Exhibit Hall
B2
Exhibit Hall
(adjacent)
Restrooms
Starbucks
Restaurant
r
ation Cente
rm
fo
In
FedexKinkos
Business Center
Harbor Drive
Restrooms
Harbor Drive
Luggage Check
Tour Desk
13
Registration Desk
45th Annual
Meeting & ToxExpo
San Diego Hotel Accommodations
1. Embassy Suites Hotel
San Diego Bay
601 Pacific Avenue
San Diego, California 92101
Tel: (619) 239–2400
Fax: (619) 696–9184
www.embassysuites.com
Rating: 4-Diamond tttt
Club: Hilton
4 blocks from the Convention
Center
4. Marriott Hotel & Marina*
333 West Harbor Drive
Tel: (619) 234–1500
Fax: (619) 234–8678
www.marriott.com/sandt
Club: Marriott
Adjacent to the Convention
Center
6. Quality Inn & Suites
(Government Rate Rooms
Only; ID required)
1430 Seventh Avenue
Tel: (619) 696–0911 or
(800) 404–6835
Fax: (619) 234–9416
www.qualityinnsandiego.com
Rating: 3-Diamond ttt
Club: Choice
Approx. 1 mile to the
Convention Center
5. Omni San Diego
2. Hampton Inn by Hilton
San Diego Downtown
MAPS
1531 Pacific Highway
Tel: (619) 233–8408
Fax: (619) 233–8418
www.SanDiegoHamptonInn.
com
Club: Hilton
675 L Street
Tel: (619) 231–6664
Fax: (619) 231–8060
www.omnihotels.com
Club: Omni
1⁄2 block from the Convention
Center
Approx. 1 mile from the
Convention Center
($6 cab fare to Convention Center)
7. Residence Inn by Marriott
San Diego Downtown
1747 Pacific Highway
Tel: (619) 338–8200
Fax: (619) 338–8219
www. SanDiegoResidenceInn.
com
Club: Marriott
Approx. 1 mile from the
Convention Center
3. Manchester Grand Hyatt*
One Market Place
Tel: (619) 232–1234
Fax: (619) 233–6464
www.manchestergrand.hyatt.
com
*Co-Headquarter Hotels
Club: Hyatt
1 1⁄2 blocks from the
Convention Center
14
45th Annual
Meeting & ToxExpo
MAPS
Downtown San Diego
SOT Annual
Meeting
111 WEST HARBOR DRIVE, SAN DIEGO, CA 92101
PHONE (619) 525–5000 • FAX (619) 525–5005
WWW.VISITSANDIEGO.COM
15
45th Annual
Meeting & ToxExpo
Manchester Grand Hyatt
Ground Level
MAPS
16
45th Annual
Meeting & ToxExpo
Manchester Grand Hyatt
Entrance from level one (First Floor)
MAPS
Second Floor
Third Floor
Third Floor
Escalators/Stairs
RESTROOMS
Restrooms/
telephones
Elevators
Fourth Floor
17
45th Annual
Meeting & ToxExpo
Bayside
SOT Guest
Hospitality
Center
Manchester
Rooms
Guest
Registration
Elevator
s
om s
Ro m
a o
bi Ro
m y
lu rre
Co To
West Lobby
Lounge
Seaview
South Tower
a
ev
El
Atlanta
oy
Sa
nD
rs
to
Parking
Chicago
er
DW’s lounge
ieg
oF
DW’s pub
Elevator to
Exhibit Hall
North Tower
Escalator
East
Lobby
Lounge
Starbucks
Escalator to
Convention Center
& Business Center
Gift
Shop
Guest
Registration
Concierge
Anaheim
San Diego
Ballroom
Marriott
Hall Drive
Bell Stand
Marriott
Hall
Gift
Shop
Loading Entrance
Gift
Shop
Hotel Entrance
New York
Orlando
San Francisco
MAPS
Lobby Level
Restrooms/Ice Machine
Yacht Club
Restaurant
& Bar
Guest Coin Laundry
Elevator
Pool
Pool
LC’s
Restaurant
Solana
Point
Loma
Parking
(3 Levels)
va
Ele
rs
to
Ele
CRAD
Services
Pacific
Oceanside
To Seaport
Village
va
to
r
Marina
Office
Elevator to
Marriott Hall
s
Leucadia
Laguna
Molly’s
Restaurant & Bar
Business
Center
Escalator
Exhibit Hall &
Parking Garage
Santa
Rosa
Walkway to
Convention
Center
First Floor
18
45th Annual
Meeting & ToxExpo
MAPS
Second Floor
Third Floor
19
45th Annual
Meeting & ToxExpo
San Diego Restaurants
MAPS
20
45th Annual
Meeting & ToxExpo
San Diego Restaurants
Restaurants within Eight Blocks of Convention Center
$=$10
$
(619) 239–3222
$$
(619) 702–5024 $$$
(619) 237–6186
$$$
(619) 234–8000
$$
(619) 702–7101 $$$
(619) 230–8995
$$
(619) 233–7391
$$
(619) 234–5555 $$$+
(619) 232–3888
$$$
(619) 239–9994
$$
(619) 557–0146
$$+
(619) 230–8888
$$
(619) 233–1653 $$$
(619) 233–7800
$$
(619) 230–0382
$$
(619) 238–5440 $$$+
(619) 231–9100
$+
(619) 234–1955
(619) 230–1968
$$
(619) 233–4355 $$$+
(619) 645–6545 $$$
(619) 696–0234
$$
(619) 234–6333
$$
$$+
(619) 358–6740 $$$
(619) 233–4300
$
(619) 232–1141 $$$
(619) 232–7581
$$
(619) 230–8424
$$
(619) 232–8226
(619) 615–7625
$$
(619) 238–0101
$$
(619) 238–0203 $–$$$
(619) 338–0008
$$
$
(619) 235–8500
$$$
(619) 702–5595
$$
(619) 234–5554
$$$
(619) 232–9840
$+
(619) 702–8464
$$
(619) 544–9779 $$$
(619) 231–6771
$$+
(619) 233–5757
$$+
(619) 231–9680
$
(619) 595–0115
$+
(619) 232–3474
$$
(619) 235–4668
$
(619) 232–4242
$$
(619) 235-8144 $$$
(619) 233–7272
$$
(619) 239–1235 $$$
(619) 234–4867 $$$$
(619) 595–7959 $$$
(619) 232–8844 $$$
Visit the SOT 2006 Annual Meeting Web site at www.toxicology.org for
a full listing of Downtown San Diego Restaurants.
21
MAPS
(619) 238–8100
45th Annual
Meeting & ToxExpo
ToxExpoTM
You probably know ToxExpoTM as the
exhibition associated with the Society
of Toxicology’s Annual Meeting—it’s
that—but it’s also a great deal more.
ToxExpoTM is:
• A complete environment to research
products and services of exhibiting
companies and keep you informed of
new cutting-edge science and technology.
Looking for a particular product or service?
Check the category listing on
www.toxexpo.com to see which companies
offer the best product or service for your needs.
• A new approach to organizing the wealth
of ideas and insights in cross-disciplinary
areas of toxicology.
It all adds up to an uncommonly rich
• The toxicology market place—your source
for product information and leads to keep
your lab competitive.
resource for the scientist,
• The place where professionals will learn
how to explore a rapidly changing science.
the toxicologist, the policy maker,
• A chance to think outside the box—find
out how your work relates to research in
other disciplines.
• Up-to-date information on state-of-theart research equipment and the latest
publications.
the educator, the student—
anyone looking for the best products and
services that toxicology has to offer!
TOXEXPO
• A 24-7 comprehensive on-line resource,
searchable by company name or by
product or service.
www.toxexpo.com
22
23
ToxExpo
Meeting
Room
203
ToxExpo
Meeting
Room
202
CRAD
Interview
Room
201
Wednesday ..... 8:30 AM–4:30 PM
Internet Cafe
Tuesday .......... 8:30 AM–4:30 PM
POSTERS
POSTERS
TOXEXPO
Tour Desk
SOT
Membership
Booth (1736)
ToxExpoTM Show
Management Office
& First Aid (upstairs)
Monday .......... 9:30 AM–4:30 PM
Entrance Restrooms Registration Starbucks
MEN
Restrooms
Concessions
Exhibit Hours:
Luggage Check
Stairs/
Elevators
Restrooms
(upstairs)
Concessions Security
ToxExpoTM in the Exhibit Hall
Restaurant Information Center
Escalator/
Stairs to
Upper
Level
Additional
CRAD
Job Bank
Center
Interview
Rooms
Another
map of
Exhibit
Hall on
page 13.
CRAD
Interview
Room
200
Wireless Internet Access
Itinerary
Planner
45th Annual
Meeting & ToxExpo
POSTERS
45th Annual
Meeting & ToxExpo
2006 Exhibitors
Company Name....................................... Booth Number
Alphabetical Listing
Carl Zeiss MicroImaging, Inc. ........................................................ 1203
Cayman Chemical ........................................................................... 842
CeeTox Inc. .................................................................................... 1021
Cellomics, Inc. ................................................................................. 349
CellzDirect...................................................................................... 1449
Centers for Disease Control and Prevention/Agency for Toxic
Substances and Disease (CDC/ATSD) ....................................... 1405
Central Institute for Experimental Animals (CIEA) ........................ 533
Central Toxicology Laboratory—Syngenta ...................................... 800
CEREP ............................................................................................... 741
CH Technologies (USA) Inc. .......................................................... 1222
ChanTest, Inc. ................................................................................ 1216
Charles River Laboratories Research Models & Services .. 630
Charles River Laboratories Pathology Services ................ 631
Charles River Laboratories Preclinical Services ............... 731
Charles River Laboratories Clinical Services..................... 831
ChemRisk ......................................................................................... 434
CLEA Japan, Inc ............................................................................... 535
Clinical Data, Inc. ................................................................ 711
CIIT Centers for Health Research ....................................... 818
Ciphergen Biosystems, Inc. ............................................................. 948
CIT.................................................................................................. 1210
Colonial Medical Supply.................................................................. 851
Colorado Histo-Prep ...................................................................... 1117
CombiMatrixCorp ........................................................................... 346
Comparative Biosciences ............................................................... 1208
CompuCyte Corporation ............................................................... 1714
CorDynamics ................................................................................... 324
Cosmetic Ingredient Review .......................................................... 1706
Covance ................................................................................. 801
Covance Research Products Inc. ...................................................... 802
Data Integrated Scientific Systems (D.I.S.S.) .................................. 1401
Data Sciences International ............................................................. 847
Definiens AG .................................................................................... 309
Detroit R & D, Inc. ........................................................................... 321
DiLab, Inc. ...................................................................................... 1619
Dow Corning Corporation ................................................ 1047
Ellegaard Göttingen Minipigs ........................................................ 1236
Elm Hill Breeding Labs, Inc. .......................................................... 1312
Elsevier Science Inc. ......................................................................... 814
EMKA TECHNOLOGIES ................................................................. 1524
Environmental Health Perspectives (EHP) ...................................... 336
EPL, Inc. (Experimental Pathology Laboratories) .......... 1005
Experimur ........................................................................................ 548
Expression Analysis .......................................................................... 438
Exygen Research............................................................................. 1138
Fraunhofer ITEM ............................................................................ 1213
Gamma Medica Ideas ....................................................................... 539
Gene Logic, Inc. .................................................................... 513
Gene Tools ..................................................................................... 1511
Genedata Inc. ................................................................................... 722
GeneGo, Inc. .................................................................................... 408
Genpathway, Inc. ........................................................................... 1352
Gentronix Limited ........................................................................... 301
GlobalTox ....................................................................................... 1200
Gwathmey, Inc. ................................................................................ 609
Hamilton Thorne Research .............................................................. 708
Hamilton-Kinder, LLC ................................................................... 1023
Harlan ............................................................................................ 1137
Hazardous Materials Information Review Commission (HMIRC) .. 333
Hemo Genix Inc............................................................................. 1124
Hilltop Lab Animals, Inc. ................................................................. 431
HistoRx, Inc. .................................................................................. 1607
Humana Press................................................................................. 1101
Huntingdon Life Sciences.................................................... 809
Hurley Consulting Associates Ltd. .................................... 1407
ICT–XI .............................................................................................. 320
IIT Research Institute ....................................................................... 918
Illumina, Inc. ...................................................................... 1503
ILSI Health and Environmental Sciences Institute ........................ 1403
In Vitro Technologies, Inc. (IVT) ...................................................... 821
Ina Research Inc. .............................................................................. 409
(As of January 1, 2006)
Please visit www.ToxExpo.com or the ToxExpoTM
Directory for product/service descriptions, a map of booth
locations, and other information.
2006 Annual Meeting sponsors are in bold.
See listing of complete sponsors on Inside Foldout.
TOXEXPO
3E Company .................................................................................... 421
AAALAC International ..................................................................... 638
Access Technologies ....................................................................... 1505
ACGIH ............................................................................................ 1100
ADMET GROUP ............................................................................... 642
ADMET Technologies ....................................................................... 435
Adriadne Genomics ....................................................................... 1606
Advinus Therapeutics Pvt Ltd .......................................................... 318
Affymetrix ........................................................................................ 836
Agilent Technologies........................................................................ 407
Alabama Research & Development ............................................... 1300
Allentown Caging Equipment CO. Inc. .......................................... 700
Althea Technologies ......................................................................... 420
ALZET® Osmotic Pumps/DURECT Corp. ........................................ 618
American Association for Laboratory Animal Science (AALAS) ...... 437
American Board of Toxicology (ABT) .............................................. 201
American College of Toxicology (ACT) ......................................... 1621
Americans for Medical Progress (AMP) ............................................ 404
Amgen .............................................................................................. 406
Ani Lytics Inc. ....................................................................... 525
Anilab, Inc. ....................................................................................... 401
Animal Identification and Marking System, Inc. (AIMS) ................ 619
Antech Diagnostics .......................................................................... 433
Aperio Technologies ....................................................................... 1119
Applied Biosystems ........................................................................ 1519
Applied Preclinical Services ........................................................... 1234
AppTec Laboratory Services ............................................................. 231
APTUIT (Allendale) Inc. ................................................................. 1131
ARC Seibersdorf research GmbH. .................................................. 1631
Arcturus .......................................................................................... 1614
AVA Biomedical, Inc. ........................................................................ 620
Aviva Biosciences ............................................................................. 449
B.I.K. Industries ................................................................................ 436
BASi (Bioanalytical Systems, Inc.) ...................................... 718
Battelle HHS ................................................................................... 1223
BBL Sciences ................................................................................... 1109
BD Biosciences ............................................................................... 1724
Beckman Coulter ........................................................................... 1604
Bench International ......................................................................... 622
BioE, Inc. .......................................................................................... 303
BioLife Solutions ............................................................................ 1152
BioLogix Research Company ......................................................... 1611
Bio Medic Data Systems Inc. ............................................................ 601
Bio-Serv Inc. ..................................................................................... 530
BIOAGRI PHARMA ........................................................................... 520
BioDynamics Research Ltd ............................................................ 1507
Biolog, Inc. ..................................................................................... 1244
Biological Test Center .................................................................... 1025
BioReliance, Invitrogen BioservicesTM ............................... 820
BioStat Consultants Inc ................................................................. 1205
Biotechnics, LLC .............................................................................. 707
Biotrin International ........................................................................ 808
Brady Corporation ........................................................................... 300
Bristol-Myers Squibb Company (BMS) ............................... 432
Burdock Group ................................................................................. 841
Buxco Research Systems................................................................. 1125
Calvert Laboratories, Inc..................................................... 930
Cambrex ......................................................................................... 1019
Cantest BioPharma Services. .......................................................... 1624
Cantox Health Sciences International ........................................... 1123
24
45th Annual
Meeting & ToxExpo
2006 Exhibitors (Continued)
Rosetta Biosoftware .......................................................................... 650
RTC, Research Toxicology Centre S.p.A........................................... 323
RTI International ............................................................................. 704
Safepharm Laboratories Ltd ........................................................... 1209
Sage Publications ............................................................................. 450
San Diego Instruments, Inc. ............................................................ 531
Scantox A/S .................................................................................... 1217
SCIREQ, Inc. (Scientific Respiratory Equipment) .......................... 1419
Sequani Limited ............................................................................. 1230
SeraCare Life Sciences, Inc. ............................................................ 1500
SFBC International ........................................................................... 534
Siemans Medical Solutions USA .................................................... 1246
Sinclair Research Center, Inc. ........................................................ 1053
Smiths Medical MD, Inc. ............................................................... 1252
SNBL USA, LTD. ............................................................................. 1239
SoBran Inc. ..................................................................................... 1506
SOT—Animals in Research............................................................. 1740
SOT—K–12 Education .................................................................... 1742
SOT—Membership ......................................................................... 1736
SOT—RALA .................................................................................... 1734
Southern Research Institute ............................................................. 422
Springborn Smithers Labs/Synergy Pharma Services..................... 1231
SRI International .............................................................................. 823
StemCell Technologies, Inc. ............................................................ 423
Stillmeadow, Inc. ............................................................................. 624
Strategic Applications, Inc. ........................................................... 1248
Suburban Surgical Company ........................................................... 724
Taconic ............................................................................................. 922
Talos MSDS Authoring and Distribution Software ........................ 1204
Tandem Labs .................................................................................. 1538
Taylor & Francis ............................................................................. 1031
The Leyden Group ........................................................................... 840
Thomson ResearchSoft................................................................... 1451
TNO ................................................................................................ 1308
Tox Monitor/BSR, Inc. ..................................................................... 636
Toxicology Education Foundation (TEF) ......................................... 308
Toxicology Excellence for Risk Assessment ..................... 1710
Toxicology Regulatory Services ........................................................ 715
Toxicology Research Laboratory ...................................................... 523
Toxikon Corporation ....................................................................... 623
ToxServices LLC ............................................................................... 812
Trevigen ............................................................................................ 646
TSE Systems, Inc............................................................................. 1302
TSI .................................................................................................... 212
U.S. Environmental Protection Agency (EPA) ................... 551
U.S. EPA, Office of Pollution Prevention & Toxics .......................... 453
U.S. EPA, Office of Research and Development............................... 550
UTAK Laboratories, Inc. ................................................................. 1501
Veritox, Inc. ................................................................................... 1201
Viking Medical/Used Caging.com ................................................... 316
VisualSonics ..................................................................................... 524
Vitrocell Systems ............................................................................ 1220
Vitron Inc ......................................................................................... 940
VivoMetrics Inc. ............................................................................. 1145
WIL Research Laboratories ................................................. 701
Wildlife International Ltd. ............................................................... 819
XCELLON—The AEgis Technologies Group, Inc. ......................... 1218
Xenobiotic Detection Systems ......................................................... 621
XenoTech, LLC................................................................................. 709
Xybion Medical Systems ................................................................ 1037
Admittance to the Exhibit Hall is limited to
attendees with full registration.
Children under the age of 15 years of age
are not allowed in the Exhibit Hall.
25
Photography is prohibited in the Exhibit Hall.
Special requests can be brought to the Show Manager.
The Show Management Office is located
in the Exhibit Hall (see map on page 23).
TOXEXPO
Instech Solomon .............................................................................. 425
Instem LSS ...................................................................................... 1431
Institute For In Vitro Sciences (IIVS) .............................................. 1425
Institute for Laboratory Animal Research (ILAR) ............................ 536
Integrated Telemetry Services (ITS).................................................. 810
International Union of Toxicology (IUTOX)................................... 305
IPS Therapeutique, Inc. .................................................................. 1136
ISIS BioComp ................................................................................. 1118
ITR Laboratories Canada, Inc......................................................... 1049
Jai Research Foundation International ............................................ 547
JCL Bioassay, Inc. ............................................................................. 549
John Wiley & Sons ........................................................................... 217
Kamiya Biomedical Company ....................................................... 1003
Kent Scientific Corporation ............................................................. 750
Kforce Scientific Staffing ................................................................ 1610
Korea Institute of Toxicology (KIT) ................................................. 737
LAB Products, Inc. ............................................................................ 500
LABCAT .......................................................................................... 1001
LabCorp............................................................................................ 522
LabCorp Preclinical .......................................................................... 403
LDS Life Science ............................................................................... 743
Leadscope Inc. ................................................................................ 1625
LHASA Limited ............................................................................... 1202
Loats Associates, Inc. ....................................................................... 648
Lomir Biomedical, Inc. .................................................................... 944
Lovelace Respiratory Research Institute (LRRI) ............................. 1103
Marshall BioResources ................................................................... 1238
MB Research Labs, Inc. .................................................................. 1122
MDS Pharma Services ...................................................................... 747
Med Associates ............................................................................... 1520
Metabometrix Ltd .......................................................................... 1518
MicaGenix ...................................................................................... 1525
Midwest BioResearch ..................................................................... 1515
Midwest Research Institute .............................................................. 506
Mouse Specifics, Inc. ...................................................................... 1148
MPI Research ........................................................................ 501
MultiCASE, Inc. ............................................................................. 1113
NIEHS/OCPL .................................................................................... 335
National Center of Toxicogenomics .............................................. 1447
National Library of Medicine .......................................................... 717
National Toxicology Program (NTP) .................................. 337
Nerviano Medical Sciences srl ....................................................... 1348
Neuroscience Associates (NSA) ........................................................ 430
Northview Biosciences ................................................................... 1106
Notocord Systems ............................................................................ 723
NOTOX B.V. ..................................................................................... 331
Nucro-Technics ................................................................................ 725
Oxford University Press ................................................................. 1120
Partek Incorporated ......................................................................... 322
Pathology Data Solutions, Inc. ........................................................ 719
Perceptive Instruments .................................................................. 1439
Perry Scientific ............................................................................... 1146
Pfizer Global Research and Development ......................... 330
Pharma Algorithms ........................................................................ 1720
Pharmalytica Services ...................................................................... 649
Phylonix ........................................................................................... 532
Physio Genix .................................................................................. 1605
Popper & Sons, Inc........................................................................... 537
PreclinOmics .................................................................................. 1615
Primanova ...................................................................................... 1150
Primate Products, Inc. (PPI) ............................................................. 950
Product Safety Labs .......................................................................... 538
Progenix Research Sdn Bhd ............................................................. 439
Promega Corp ................................................................................ 1102
Purina Mills LabDiet ........................................................................ 400
Q-Test ............................................................................................. 1253
Quest Pharmaceutical Services, L.L.C. (QPS) ................................... 640
Risk Assessment Summer School (RASS).......................................... 307
RCC Ltd. ......................................................................................... 1330
ReCathCo LLC ............................................................................... 1423
Research Diets, Inc. ........................................................................ 1718
Ricerca Biosciences ........................................................................... 519
REGISTRATION
Registration
45th Annual
Meeting & ToxExpo
Annual Meeting Registration
Includes:
Annual Meeting
Registration Fees:
• San Diego University Choral Scholar Performance,
Sunday, March 5 at 4:45 PM.
On-Site
SOT Member ........................................................$350
• Awards Ceremony Celebrating 45th Anniversary,
Sunday, March 5 from 5:15 PM–6:30 PM.
Non-Member ....................................................... $600
SOT Retired Member ............................................$145
• Welcoming Reception Celebrating 45th Anniversary,
Sunday, March 5 from 6:30 PM–7:30 PM.
Post-Doctoral SOT Member .................................$160
Post-Doctoral Non-Member .................................$240
• Plenary Lecture, Monday, March 6 from
8:30 AM–9:15 AM.
Graduate Student SOT Member...........................$140
Graduate Student Non-Member ..........................$200
• All Scientific Sessions (see program descriptions
beginning on page 57) 9:30 AM, Monday, March 6
through 12:00 NOON, Thursday, March 9.
Undergraduate Student ........................................$140
SOT Affiliate ...........................................................$ 0
Press........................................................................$ 0
• ToxExpo™ Exhibit Hall, 9:30 AM Monday, March 6
through 4:30 PM Wednesday, March 8.
Guest (Non-Scientist) ...........................................$100
(Guests do not have member or registrant privileges)
Participants are also encouraged to register for the Continuing Education Courses. These are available during three
time intervals on Sunday, March 5: the Sunrise Mini-Course is
from 7:00 AM–7:45 AM; morning courses are 8:15 AM–12:00
NOON; and afternoon courses are from 1:15 PM–5:00 PM.
Continuing Education Course
Fees: (per AM or PM course)
(Only Annual Meeting Registrants may enroll in CE
Courses)
Registration Desk
On-Site
Registration Desk will be located in Hall A Lobby.
Registration Desk Hours:
Saturday ................................................. 4:00 PM–7:00 PM
Sunday....................................................7:00 AM–8:00 PM
Monday ..................................................7:00 AM–5:00 PM
Tuesday ..................................................8:00 AM–4:00 PM
Wednesday .............................................8:00 AM–4:00 PM
Thursday ............................................. 8:00 AM–11:30 AM
SOT Member/SOT Affiliate ..................................$150
Retired ..................................................................$145
Non-Member ........................................................$250
Post-Doctoral
(SOT Member or Non-Member) ..................$125
Graduate or Undergraduate Student
(SOT Member or Non-Member)...................................................... $
80
Press........................................................................$ 0
Continuing Education Sunrise
Mini-Course Fees:
Registration Materials
Register before February 7, 2006, and your badge and
registration materials will be sent to you three weeks
prior to the Annual Meeting. Your 2006 Annual Meeting
Registration badge must be presented to obtain access to
SOT functions.
(includes continental breakfast)
On-Site
SOT Member/Affiliate ........................................... $ 95
Post-Doctoral (SOT Member or Non-Member) ................... $ 95
Retired ................................................................... $ 95
When you arrive at the San Diego Convention Center,
please pick up a badge holder. You do not need to wait
in the registration line if you already have a badge. Your
2006 Annual Meeting registration badge must be presented to obtain the registration materials (i.e., The
Toxicologist on CD-ROM, the ToxExpoTM Directory and other
supplementary materials).
Non-Member ........................................................ $115
Graduate or Undergraduate Student ....................$ 65
Press ............................................................................................. $ 0
26
Exhibit Hall (Hours/Location)
SOT 45th Anniversary Raffle Contest will be held in the
Exhibit Hall Monday, Tuesday, and Wednesday between
12:00 NOON and 1:30 PM. As part of the 45th Anniversary
Celebration, SOT will be giving away a total of $4500 over
a three-day period! More details and contest rules are on
the SOT Annual Meeting Web site at www.toxicology.
org and in the Exhibit Hall on-site.
Exhibit hours at the Convention Center are as follows:
Monday ..................................................9:30 AM–4:30 PM
Tuesday ..................................................8:30 AM–4:30 PM
Wednesday .............................................8:30 AM–4:30 PM
A map of the Exhibit Hall is located on page 23. Exhibitor
personnel and poster presenters may enter the Hall one hour
before the Exhibit Hall opens with appropriate identification.
Accessibility for Persons with
Disabilities
Exhibit Hall Policy
Admittance to the Exhibit Hall is limited to attendees with
full registration. Guest Registrants and Children under the
age of 15 years of age are not allowed in the Exhibit Hall.
The San Diego Convention Center and most of the SOT
hotels are accessible to persons with special needs. If you
require special services, please mark the appropriate box
on the Housing Request Form and the Registration Form.
If you require more information about disabled access,
please contact Heidi Prange at SOT Headquarters: (703)
438–3115 Ext. 1424 or E-mail: [email protected].
Photography is prohibited in the Exhibit Hall. Special requests
can be brought to the Show Manager. The Show Management
Office is located in Exhibit Hall A, back right corner, upstairs.
First Aid
Attire
If an emergency occurs at the San Diego Convention
Center, proceed to the nearest house phone in the foyer
areas throughout the Center and dial 5911 or 5490. You
will be connected to Security/Guest Services. These numbers are accessible 24 hours a day.
The official attire for the Annual Meeting is business
casual. No coat or tie is required! We encourage you to
bring comfortable clothing and extra shoes.
Badges
SOT will also provide a First Aid Office that will be open
during exhibit move-in, move-out, and scientific session
hours. The First Aid Office is located in the Show Management Office at the back right corner of Exhibit Hall A,
upstairs. First aid is provided by First Aid Services of San Diego.
Annual Meeting attendees who have registered before
February 7, 2006 will receive badges and registration
materials in the mail. If you already have your 2006
Annual Meeting badge you do not need to wait in the
registration line.
Convention Center First Aid Office hours:
Saturday ................................................ 3:00 PM–8:00 PM
Sunday................................................... 7:00 AM–8:00 PM
Monday ................................................. 7:00 AM–6:00 PM
Tuesday ................................................. 7:00 AM–6:00 PM
Wednesday .......................................... 7:00 AM–10:00 PM
Thursday .............................................8:30 AM–11:30 AM
If you have not registered for the meeting, please complete
the on-site registration form and proceed to the appropriate registration line.
Business Center
A FedEx Kinko’s office and print center is located in
Hall D Lobby of the San Diego Convention Center. Hours
of operation are Monday–Friday, 8:00 AM–5:00 PM;
Saturday–Sunday, 9:00 AM–5:00 PM. Contact Debbie
Nunez, Convention Services Manager at (888) 215–1857
or E-mail [email protected]. The business
service center offers shipping, mailing, photocopying,
binding, computer rentals, and e-mail access.
Food Services
Coffee Breaks
The Exhibiting Companies are pleased to sponsor complimentary coffee in the Exhibit Hall between 9:30 AM–
10:30 AM, Monday through Wednesday. See Exhibit Hall
signage for locations.
27
GENERAL INFO
General Information
45th Annual
Meeting & ToxExpo
GENERAL INFO
General Information (Continued)
45th Annual
Meeting & ToxExpo
Concessions
Did you know that your choice of hotel for the SOT Annual
Meeting has a direct impact on the Society’s Long-Range
Plan initiatives? Although we understand that making
your reservations outside of the SOT block can sometimes
be more economical, it decreases the money available to
the Society to carry out its long-term goals and may cause
the Society to have to pay attrition fees for unutilized
rooms. In addition, the Society is unable to assist you
if you have any difficulties with your room reservation,
such as the hotel over-booking or misplacing your reservation.
Concession stands are available during Exhibit Hall
hours. Exhibit hours are listed under Exhibit Hall in the
General Information Section. Breakfast and lunch items
are available, as well as coffee, soda, bottled water, and
snacks for purchase.
Restaurants
A Restaurant Information Center will be located in the
Hall B2 Lobby on the Ground Level of the San Deigo
Convention Center. Restaurants located within eight
blocks of the Convention Center are located on pages 20
and 21 with a map of downtown San Diego. A full listing of
restaurants by cuisine and price can be viewed on the SOT
Annual Meeting Web site at www.toxicology.org.
SOT depends on the Annual Meeting revenue to fund
other programs throughout the year and to keep future
registration fees low. Please assist the Society by making
your hotel reservation through the San Diego Housing
Bureau.
Housing Desk
and Program
For information regarding your hotel room reservation,
please visit the SOT Housing Desk located in Hall B Lobby
on the Ground Level of the Convention Center. The
deadline for housing reservations is February 8, 2006.
The SOT Guest Hospitality Center provides guest participants (non-scientists) with a place to meet and socialize
with other guests. To visit the Hospitality Center, guests
must register for the Annual Meeting using the same
Registration Form as the person they are accompanying.
Guests are welcome to attend the Welcoming Reception
Celebrating the 45th Anniversary of SOT, but will not have
access to the scientific sessions or the Exhibit Hall. Please
remember to wear your badge to all SOT events.
Housing Desk hours:
Saturday ................................................ 4:00 PM–7:00 PM
Sunday................................................... 7:00 AM–5:00 PM
Monday ................................................. 7:00 AM–5:00 PM
Tuesday ................................................. 8:00 AM–4:00 PM
Wednesday ............................................ 8:00 AM–4:00 PM
Thursday .............................................8:00 AM–11:30 AM
The Guest Hospitality Center will be located in the
Manchester Room at the Marriott Hotel & Marina.
Guest Hospitality Center hours:
Methods for Making Housing Reservations
Sunday................................................... 8:00 AM–4:30 PM
Monday ................................................. 8:00 AM–4:30 PM
Tuesday ................................................. 8:00 AM–4:30 PM
Wednesday ............................................ 8:00 AM–4:30 PM
Thursday .............................................8:00 AM–11:30 AM
On-Line
www.toxicology.org
Telephone
Toll-Free (USA): (800) 676–5026
International: (330) 405–7884
Fax
(330) 963–0319
Mail
SOT Housing Bureau
2451 Enterprise Parkway East
Twinsburg, OH 44087
United States
Housing Information and
Reservations
E-mail
[email protected]
The Society of Toxicology has reserved discounted room
rates at various San Diego hotels—known as the SOT
hotel block for SOT Annual Meeting attendees. This block
includes discounted room rates at many premier hotel
chains. In order to secure these discounted room rates,
you will need to make your hotel reservation through the
San Diego Housing Bureau.
28
Internet Access and
Electronic Devices
Luggage Check hours:
Sunday................................................... 7:00
Monday ................................................. 7:00
Tuesday ................................................. 7:00
Wednesday ............................................ 7:00
Thursday ............................................... 7:00
As technology advances, SOT realizes how important it
is for attendees to learn the latest scientific discoveries at
the meeting while using technology to stay connected
to daily responsibilities. SOT will have stations available
in the Hall B Lobby (Message Center) and ToxExpoTM to
check your e-mail and connect to the Internet. In addition, “Hot Zones” in the Exhibit Hall will offer wireless
Internet access via your personal laptop computer or other
devices. These areas will be clearly marked with bright
signage. Please look at the Exhibit Hall map on page 23
for designated areas.
PM
PM
PM
PM
PM
Luggage check hours are subject to change.
Media Support Services
The Society of Toxicology welcomes accredited representatives of media organizations. Journalists may receive
complimentary credentials for all meeting sessions, as
well as a complete media kit, by contacting Lilly
Richards at SOT Headquarters: (703) 438–3115 or E-mail:
[email protected]. On-site, media kits can be picked up
at the SOT Headquarters Office, Room 14A, in the San
Diego Convention Center.
Instructions for Wireless Internet Access
To access the wireless connection:
1. Open your wireless software on your computer and
view available wireless networks.
Memorabilia
2. Look for a wireless network called ToxExpo2006. For
most configurations, you will highlight ToxExpo2006
and select Connect.
Shirts, portfolios, and other items customized for SOT
are available for order on-line to pick up at the Annual
Meeting. Visit the SOT Web site at www.toxicology.org
or contact SOT Headquarters to request an order form.
Merchandise will also be available for sale at the Annual
Meeting in the Memorabilia Booth in the Upper Level
Ballroom 6 Lobby of the San Diego Convention Center.
3. No password is required to use this wireless Internet
connection.
Electronic Devices
As a courtesy to meeting attendees, electronic devices
must be operated in silent/vibrate mode within scientific
sessions; devices that beep, ring, etc., are prohibited.
Silence is golden. Please do not conduct cell phone
conversations while attending a scientific session. Your
cooperation is appreciated.
Message Center
This year you will be able to send and recieve messages
electronically. The Message Center will be located in
Hall B Lobby on the Ground Level of the Convention
Center and is designed to facilitate interaction among
the attendees during the Annual Meeting. SOT members,
CRAD Job Bank registrants, and Annual Meeting attendees will have access to the Annual Meeting Message
Center through a direct link from the SOT Web site using
the computers at the Message Center or any computer
with an Internet connection. The telephone number to
the Message Center is (619) 525–6250.
Lost and Found
Lost and found articles may be brought to the SOT Headquarters Office, Room 14A, of the San Diego Convention
Center. Any items left in the SOT Headquarters Office
after 11:30 AM, Thursday, March 9 will be deposited at
the Security Office at the Convention Center.
Message Center hours:
Luggage Check
Saturday ................................................ 4:00 PM–7:00 PM
Sunday–Monday ................................... 7:00 AM–5:00 PM
Tuesday–Wednesday ............................. 8:00 AM–4:00 PM
Thursday .............................................8:00 AM–11:30 AM
For your convenience, a luggage check area will be located
in Hall B2 Lobby in the San Diego Convention Center.
There will be a fee of $2.00 per item checked and laptop
computers will be accepted as long as they are in a case.
AM–8:30
AM–8:30
AM–8:00
AM–8:00
AM–1:00
29
GENERAL INFO
45th Annual
Meeting & ToxExpo
GENERAL INFO
45th Annual
Meeting & ToxExpo
Photography Policy
• In the unlikely event that outsiders disrupt a
scientific session or other event, SOT security officials
have developed a contingency plan. Please follow
directions from the chairperson and avoid becoming
involved in the situation.
Photography of scientific presentations and poster presentations is prohibited without the specific consent of the
presenter(s)/author(s). Session chairs are asked to strictly
enforce this policy and individuals who do not comply
will be asked to leave the session. In addition, cameras and
recording devices are prohibited in the Exhibit Hall. If you
have any questions regarding this policy, please see Show
Manager, located in the Exhibit Hall, right back corner,
upstairs.
Other Safety Actions Include:
• Walk “smart” when you leave the Convention Center.
• Know your destination and the best way to reach it.
• Travel along sidewalks in lighted areas at night, and
don’t walk alone.
Registration
• Establish a “buddy” system with another delegate to
the convention.
Full registration details may be found on page 26.
• Share schedules and check up on each other
periodically.
Registration Desk Hours
• Build your awareness of unknown surroundings by
reviewing local information.
The Annual Meeting Registration Desk is located in the
San Diego Convention Center Lobby A.
• Laptop computers are attractive, easy targets for
thieves. Be sure your laptop is in a secure place.
Registration Desk hours:
Saturday ................................................ 4:00 PM–7:00 PM
Sunday................................................... 7:00 AM–8:00 PM
Monday ................................................. 7:00 AM–5:00 PM
Tuesday ................................................. 8:00 AM–4:00 PM
Wednesday ............................................ 8:00 AM–4:00 PM
Thursday .............................................8:00 AM–11:30 AM
• Jackets with pockets provide a convenient alternative
for women to reduce the chance for lost or stolen
handbags.
Our first priority is safety. The best way to stay safe is
to be aware of your surroundings and to avoid situations
where you feel uncomfortable.
Safety and Security
SOT Headquarters Office
The possibility of demonstrators is very real given the
nature of our conference. Events of this kind range
from verbal confrontations, protests, strikes, to riots. We
recommend the following procedures in the event of
demonstrations:
The SOT Headquarters Office is located in the San Diego
Convention Center, Room 14A.
SOT Headquarters Office hours:
Saturday ................................................ 4:00 PM–7:00 PM
Sunday................................................... 7:00 AM–5:30 PM
Monday ................................................. 7:00 AM–5:00 PM
Tuesday ................................................. 7:00 AM–4:00 PM
Wednesday ............................................ 7:00 AM–4:00 PM
Thursday .............................................7:00 AM–11:30 AM
• Have your name badge available upon entering the
Convention Center. Wear your name badge in the
Convention Center. When leaving the facility, remove
it so as to blend with other people.
• If you see a demonstration or protest beginning,
please contact any member of the SOT Annual
Meeting staff and they will initiate SOT response. If
you see actions that appear threatening, notify the
nearest security officer.
Speaker Ready Room
The Speaker Ready Room will be located in the SOT
Headquarters Office (Room 14A) and is available during
the SOT Headquarters Office hours listed above.
• Do not engage, defend either side, or subdue person(s)
in any type of disturbance. Demonstrators are usually
trying to attract media attention. Don’t help them!
• SOT representatives will respond to media inquires.
Do not participate in interviews or other media
responses.
30
Sponsorship
Taxi Service
The Society would like to invite your organization to be
a proud sponsor of the Annual Meeting. SOT appreciates
the generous contributions of sponsors that make the
SOT Annual Meeting possible. Sponsor names are prominently displayed on the Annual Meeting and ToxExpoTM
Web sites, as well as in print materials that are distributed
before and during the Annual Meeting. Sponsorship is
also recognized through signage displayed around the
Convention Center during the Annual Meeting.
Taxi Fares from the San Diego International Airport to
downtown are approximately $8–$10 one-way.
Five can ride for the price of one! Taxicab stands are
located at the airport, most hotels, attractions, and shopping centers. Your fare will be displayed on the meter and
will include a flag drop charge plus a per-mile and/or a
per-hour charge. All cabs leaving the airport charge the
same rate. Rates for all other cab trips may vary from
company to company.
There are five levels of sponsorship available: Diamond
(over $10,000), Platinum ($5,000–$9,999), Gold ($2,500–
$4,999), Silver ($1,000–$2,499) and Contributor ($500–
$999). You will find a complete menu of sponsorships
at www.toxicology.org. Other promotional opportunities can be reviewed at www.ToxExpo.com.
Car Rental
Avis is the official car rental company for the SOT Annual
Meeting and special low rates have been established.
Special group rates are good one week before and after
the event, so you can take in the sights and explore the
surroundings at your own pace. The Avis Car Rental
Group Meetings & Group Sales Desk is staffed by helpful,
friendly representatives who are specially trained experts
at handling all your car rental needs. Call Avis directly at
(800) 331–1600 to reserve your car. Be sure to mention
your Avis Worldwide Discount Number (AWD) T534999.
For detailed information about SOT sponsor and promotional opportunities, please contact Libby Jones at SOT
Headquarters: (703) 438–3115 or E-mail: libby@toxicology.
org.
Transportation
San Diego offers many modes of transportation for travel
to and from and around the city. Full transportation
information can be found at www.toxicology.org.
Amtrak Train
Amtrak provides rail travel to and from San Diego with
11 round-trips per day to Los Angeles, continuing to
Santa Barbara and San Luis Obispo. The Santa Fe Depot
(Amtrak) is located in the heart of downtown San Diego,
within walking distance of the San Diego Convention
Center, Maritime Museum, Contemporary Art Museum,
Children’s Museum, Harbor Excursion cruises, Seaport
Village, Horton Plaza, and the San Diego Concourse.
Whether you are traveling to San Diego by rail or taking
a short trip between San Diego’s three picturesque coastline stations (Old Town, Downtown, and San Diego Zoo),
Amtrak offers daily service. For schedules and fares, call
(800) USA-RAIL or visit www.amtrak.com.
Airport Transportation
Shuttles and taxis are the best mode of transportation to
and from the San Diego International Airport.
Shuttle Service
Cloud 9 Shuttle, San Diego International Airport’s shuttle
service, offers on-line reservations to and from the Airport.
SOT attendees will receive a discount fare of $6 one-way
(shared van service) for 1 passenger from the airport
to all official SOT hotels when they make their shuttle
reservations using the Cloud 9 Shuttle on-line reservation system. To make your reservation, visit the Cloud 9
Shuttle Web site at www.cloud9shuttle.com or call
(800) 974–8885 and identify yourself as being with the
SOT Annual Meeting to receive a discount. Cloud 9 Shuttle
also offers charter service including sedans, limousines,
and extended passenger vans.
Bus and Trolley
San Diego County provides convenient transportation to
and from the airport, all shopping centers, attractions,
beaches, hotels, and Mexico via the Metropolitan Transit
System, public transportation, MTS buses, trolleys, and
coasters.
Bus schedules differ, but most hotels and attractions have
service every 15 to 20 minutes. The San Diego Trolley
runs every 15 minutes throughout most of the day and
31
GENERAL INFO
45th Annual
Meeting & ToxExpo
GENERAL INFO
45th Annual
Meeting & ToxExpo
The Toxicologist/Itinerary Planner
(Print and CD-ROM)
every 30 minutes in the evening. The North County
Coaster runs 43 miles along the coast with station stops in
downtown San Diego, Old Town, Solana Beach, Encinitas,
Carlsbad, and Oceanside. You can also get a free trolley
transfer that will take you to Tijuana. All MTS buses, trolleys and coasters are equipped with wheelchair lifts. For
schedule and fare information contact the Metropolitan
Transit System at (619) 233–3004 or visit their Web site at
www.sdcommute.com.
All Annual Meeting registrants receive a copy of this
Program and The Toxicologist on CD-ROM, a special issue
of Toxicological Sciences that includes all meeting abstracts.
Special software on the CD, the Itinerary Planner, allows
the meeting attendee to search the meeting abstracts and
develop a personalized schedule for the meeting.
1. SOT members in the U.S. and Canada will receive
the Program and The Toxicologist on CD-ROM (with
Itinerary Planner) prior to the meeting, as will U.S.
and Canadian non-members who pre-register by
January 9, 2006. A printed version of The Toxicologist
will be available on-site in the registration area for a fee
of $20. Registrants may reserve a copy by signing up on
the Registration form or may purchase a copy on-site,
while supplies last.
Tour Information
For tour information, visit the Tour Desk located in the
Registration area.
Tour Desk hours:
Saturday, March 4 ................................. 4:00 PM–7:00 PM
Sunday, March 5 .................................. 7:00 AM–5:00 PM
Monday, March 6 ................................. 7:00 AM–5:00 PM
Tuesday, March 7 .................................. 8:00 AM–4:00 PM
Wednesday, March 8 ............................. 8:00 AM–4:00 PM
Thursday, March 9 ..............................8:00 AM–11:30 AM
Tour desk hours are subject to change.
2. Non-member registrants in the U.S. who register after
January 9 will receive the printed Program and The
Toxicologist on CD-ROM (with Itinerary Planner) at the
registration area on-site.
3. The Annual Meeting Itinerary Planner will be available
on the SOT Web site January–March.
If you are interested in signing up in advance for tours,
please visit the Event Team Web site at www.eventteam.
com/sottours.html. The deadline date is February 14,
2006. All cancellations must be received by Tuesday,
February 14, 2006, in writing, faxed to (619) 785–5822,
or e-mailed to [email protected]. There will be no
cancellations on-site.
4. There will be computer kiosks available in the Exhibit
Hall (see map on page 23) to search The Toxicologist
on CD-ROM (with Itinerary Planner) at the Annual
Meeting.
5. International members who do not attend the Annual
Meeting may contact the Headquarters office to request
a copy of the printed 2006 Program and The Toxicologist
on CD-ROM. The materials will be mailed following
the Annual Meeting.
Tour buses will be departing from the Hall A Main
Entrance Lobby of the San Diego Convention Center.
Tour Tickets
NOTE: Please bring your copy of the Program with you to the
meeting.
Tickets can be picked up on-site at the Tour Desk and will
not be mailed in advance.
Weather
San Diego’s sun-sational climate makes it the ultimate
year-round destination. In March, the average daytime
temperature is a pleasant 66°F. The average nighttime
temperature is 52°F. The average annual rainfall is less
than 10 inches. A jacket or sweater is recommended.
32
33
Career Resource and Development Services
45th Annual
Meeting & ToxExpo
CAREER SERVICES
The Career Resource and Development (CRAD) Services
include an on-line Job Bank, special Job Bank activities at
the SOT Annual Meeting, career development seminars
and resources, and employer ads in SOT’s newsletter, the
Communiqué, which reaches the entire SOT membership
and beyond.
e-mail message created from within the system. You
may also contact these companies or candidates directly
by phone or fax.
CRAD Services can facilitate interviews at the SOT
Annual Meeting. Employers and candidates can schedule
appointments, both in the CRAD interview rooms at the
Marriott Hotel and Marina or in the ToxExpoTM.
CRAD Job Bank Services
The Society’s on-line CRAD Job Bank makes it easy for candidates and employers alike to access this year-round service
anytime, anyplace from the SOT Web site at www.toxicology.
org. This forum links job candidates with employment positions in toxicology and related biological sciences.
How CRAD Job Bank Works
The CRAD Web site is accessed through the SOT Home
Page at www.toxicology.org. Simply select “Career
Resource and Development Services” from the Homepage,
then select “Career Resources” from the drop-down
menu and you will be directed to the CRAD Job Bank.
To register, you have the option of paying by credit card
on-line or faxing in your credit card information. (See fee
schedule below).
• Candidates can gain access to a variety of positions that
will be suited to their experience, areas of expertise, and
desired geographical location. By posting resumes in
this readily accessible Job Bank, employers can review
resumes and determine an appropriate match for the
positions available. SOT Student Members can use
this service at no charge. SOT Student Members who
register for the Job Bank before the Annual Meeting
will not be charged the $20 on-site registration fee.
Once you have completed the registration and submitted
a payment, you may complete either the employer or
candidate profile form.
• Your job description or candidate profile is then added
to the database and remains active for six months.
• Employers from corporate, academic, and nonprofit
organizations can attract potential candidates in a
targeted and cost-effective manner through this CRAD
service. By having access to detailed candidate resumes,
employers can determine the right match for a specific
position and expedite the recruitment process. SOT
Affiliates are entitled to one complimentary posting.
• During the six-month period, you may update your
registration information, browse the jobs listed
or candidate pool, conduct searches for a job or
candidate that fits a certain profile, search for a part- or
full-time position or terminate your registration.
You may also enter the system anonymously and browse
the information within the database. Some employers
and candidates prefer to maintain their anonymity and
the system provides this option. However, employers will
not be able to search for candidates in this category.
• Registrations are continuously processed and valid for
six months so there is fresh information regarding candidates and employment positions on an ongoing basis.
• Once you have located a position or candidate of interest
from the database, communication can be made via an
FEE SCHEDULE:
Candidate Registration
SOT Member
Assisted*
Non-Assisted
Non-Member
Assisted*
Non-Assisted
Student
Assisted*
Non-Assisted
Registration
Fee
On-Site
Registration
Fee
60.00
30.00
60.00
30.00
120.00
80.00
180.00
90.00
40.00
No Fee
40.00
20.00
Employer Registration
Position
Registration
Fee
On-Site
Intro** Registration
Positions
Fee
SOT Corporate Associate
Assisted*
225.00
Non-Assisted
175.00
50.00
25.00
400.00
225.00
Corporation
Assisted*
Non-Assisted
450.00
350.00
50.00
50.00
675.00
525.00
Academic/Nonprofit
Assisted*
200.00
Non-Assisted
100.00
50.00
50.00
300.00
150.00
34
*The assisted fees
apply to those
companies or
individuals who
request that CRAD
Representatives input
information or perform
searches.
**The Introductory
Positions Fee applies
to each position added
within 7 days of
Registration.
Career Resource and Development Services
Two weeks before your six month expiration date, the
system will send you an e-mail message notifying you that
your information will soon be purged. At that time, you
can renew for another six months. All users are encouraged to complete our on-line customer satisfaction survey
after using the Job Bank. Your feedback helps us understand how to improve this system.
opportunity for personal contact. You are not required
to register for the Annual Meeting in order to utilize the
CRAD Job Bank Center. If you are a candidate attending
the Annual Meeting, you are encouraged to bring multiple
copies of your personal resume for interested interviewers.
2006 Annual Meeting CRAD Job Bank Center
All users with current registrations at the time of the
SOT Annual Meeting can use this service. Although preregistration is encouraged, registrations for the CRAD Job
Bank will be accepted at the meeting. Through the CRAD
Job Bank Center and services described below:
CRAD Interview Rooms ...........................................Pacific
CRAD Message Center ............................................ Solano
CRAD Job Posting Room ................................ Point Loma
CRAD Registration Office ....................................Leucadia
There are additional interview facilities in the San Diego
Convention Center Exhibit Hall (see map on page 23).
• You can register as an employer or candidate,
Hours of operation:
• You can search the Job Bank database,
Sunday (Registration Only) ................ 10:00 AM–3:30 PM
Monday–Wednesday
(All Services Available) ..................... 8:00 AM–4:00 PM
Thursday (Message Center
Bulletin Board Only) ............... 8:00 AM–12:00 NOON
• You can schedule interviews,
• You can send/retrieve messages electronically, and
• You can post hard copy messages.
To maximize your time and the benefits of these services,
job and candidate searches should be conducted before you
arrive at the Annual Meeting. Employers and candidates will
have access to computers, but computer use will be restricted
to registration or to short searches for new information.
New electronic innovations this year will allow greater
access to the CRAD Job Bank and messaging services.
• Candidates can log onto the Job Bank using one of the
terminals in the SOT ToxExpoTM Internet Café, or their
own personal computer.
• Additionally SOT members, CRAD Job Bank registrants
and Annual Meeting attendees will have access to the
Annual Meeting Message Center through a direct link from
the SOT Web site using computers at the Message Center,
in Hall B, or any computer with an Internet connection.
To ensure privacy for candidates, the CRAD Job Bank Center
is located away from the scientific sessions. It is up to the
registrants of the CRAD Job Bank to exercise the confidentiality options that are offered. SOT is not responsible for
the release of any information contained in the CRAD Job
Bank database. Be advised that all career service activities at
the SOT Annual Meeting will be carried out via the CRAD
Job Bank Center. Only employers who are registered on the
CRAD Job Bank will be allowed to advertise positions.
The CRAD Message Center facilitates contact between candidates and employers and also offers interview areas at the
meeting. Neither employers nor candidates need be present
at the meeting; however, both are encouraged to use this
CRAD Job Bank Center Locations are as follows
at the Marriott Hotel & Marina:
For further information, contact:
Tierre Miller
SOT Career Services
Tel: (703) 438-3115
Fax: (703) 438-3113
E-mail: [email protected]
www.toxicology.org
Employer Ads in SOT Communiqué
The Society’s newsletter, the Communiqué, is published
four times annually. It includes career opportunity advertisements for employers from corporate, academic and
nonprofit organizations wishing to reach the entire SOT
membership and beyond. For more information, contact
[email protected].
CRAD Seminars Series
The CRAD Committee provides other resources for career
development of toxicologists, including seminars and
web-based resources. To help with career development,
plan on attending this year’s CRAD Seminars, including
the following.
• “Life After Your Post-Doc: Advice on Finding and
Landing a Job,” Monday, March 6, 2006, 4:30 PM–
6:00 PM, San Diego Convention Center, Room 2.
• “SOT Grantsmanship Forum—Sources for Funding
Support,” Wednesday, March 8, 2006, 4:30 PM–6:00 PM,
San Diego Convention Center, Room 6E.
35
CAREER SERVICES
45th Annual
Meeting & ToxExpo
45th Annual
Meeting & ToxExpo
Social Events
Awards
Ceremony
Specialty Section &
Special Interest Group
Receptions
Sunday, March 5, 5:15 PM–6:30 PM
Room 6C
Join us as SOT honors our prestigious
award winners at the SOT Awards
Ceremony. Please refer to pages 37–42
to learn more about the 2006 winners
and the SOT Web site for complete
details and the nominating forms for
next year.
Welcoming
Reception
SOCIAL
SOCIALEVENTS
EVENTS
Sails Pavilion
Start the 45th Anniversary Celebration,
by attending the Welcoming Reception
following the Awards Ceremony.
The Welcoming Reception is a great
opportunity to renew old friendships
and to make new acquaintances. Please
join the Society in this kick off of the
45th Annual Meeting.
25-Year
Member
(or More) Reception
Monday, March 6 through
Wednesday, March 8,
12:00 NOON–1:30 PM and
6:00 PM–7:30 PM
Student/Post-Doctoral
Fellow Mixer
Room 33
All students and post-docs are invited
to attend this reception. Refreshments
will be provided by SOT and sponsors.
A cash bar will also be available.
Ticket and meeting badge are required.
Post-Doctoral Assembly
Event
Room 32
Join your post-doctoral colleagues,
after a visit to the Student/PostDoctoral Fellow Mixer, at the
Post-Doctoral Assembly Event. The
Post-Doctoral Assembly (PDA) is the
formal group for these members. Take
this opportunity to network with each
other, discuss issues of importance
to you, plan activities, and get to
know the new PDA Board members
for 2006–2007. The featured speaker
is Jose Manautou, 2006 Achievement
Award recipient. Light appetizers and a
cash bar will be available.
Room 4
Have you been a member of the Society
of Toxicology for 25 years (or more)?
If so, please join your colleagues
in celebration of the Society’s 45th
Anniversary and recognition of the
scientists who established the Society.
Invitation required.
36
Each of the SOT Specialty Sections
and Special Interest Groups (SIG) will
hold a meeting/reception during the
2006 SOT Annual Meeting. All current
and prospective SOT Specialty Section
and SIG members are encouraged
to attend. Please check the Event
Calendar beginning on page 2 for a
listing of meeting and reception times.
Regional Chapter
Receptions
Monday, March 6 through Wednesday,
March 8, Various Times
Many of the SOT Regional Chapters
meet during the SOT Annual Meeting.
A list of Regional Chapter reception
times and locations can be found in
the Event Calendar beginning on
page 2.
45th
Anniversary
Raffle Contest
Monday, March 6 through
Wednesday, March 8,
12:00 NOON–1:30 PM
Exhibit Hall
SOT 45th Anniversary Raffle Contest
will be held in the Exhibit Hall
Monday, Tuesday, and Wednesday
between 12:00 NOON and 1:30
PM. As part of the 45th Anniversary
Celebration, SOT will be giving away a
total of $4500 over a three-day period!
More details and contest rules are
posted on the Annual Meeting
Web site.
2006 Award Winners
45th Annual
Meeting & ToxExpo
Dr. Jose Manautou is a highly deserving candidate for the
2006 SOT Achievement Award. His outstanding research
and professional accomplishments place him among an
elite few in the field of toxicology.
Achievement Award
The Awards Committee of the Society
of Toxicology is honored to have
selected Dr. Jose E. Manautou as the
recipient of the 2006 Achievement
Award for significant contributions to
the field of toxicology.
Arnold J. Lehman Award
Dr. Kate Mahaffey’s contributions to
our understanding of the risk posed by
metals such as lead and methylmercury
date back over 30 years. Her early work
demonstrated that the toxicity of lead
could be modulated through its interactions with other essential metals such
as iron and calcium. She extended these
efforts through both clinical studies
and use of the N-HANES data sets and
Kathryn
to corresponding risk assessments for
Mahaffey
lead that played an important role in
the evolving regulatory decisions limiting the exposures
of children to lead in the U.S. Similarly, Dr. Mahaffey
has also contributed at several levels to the regulatory
process for limiting exposure of women of childbearing
age and children to methylmercury exposure through fish
consumption. She was one of the principal authors of the
EPA’s Mercury Study Report to Congress that served as
the background for alerting the scientific and regulatory
communities to the health risks posed by methylmercury
and for identifying subpopulations at highest risk from
such exposures. This award is granted in recognition
of her past and continuing contributions to regulatory
affairs and to risk assessment of chemical agents, particularly on the health risks associated with exposures
to the toxic metals lead and methylmercury.
Dr. Manautou completed his undergraduate training in pharmacy at the
University of Puerto Rico in 1985
Jose E.
and went on to carry out graduate
Manautou
work at Purdue University. His Ph.D.
research under the direction of Dr. Gary Carlson focused
on the capacity of the lung to metabolize ethanol via
oxidative, non-oxidative (esterification with free fatty
acids) and conjugative pathways, such as glucuronidation
and sulfation. After completing his graduate studies, he
accepted a post-doctoral position in biochemical toxicology at the University of Connecticut in the laboratory of
Dr. Steven Cohen; he then joined the faculty at the
University of Connecticut in the Department of
Pharmaceutical Sciences. For the past 10 years as an independent academic scientist, Dr. Manautou’s research efforts
built on early findings from his post-doctoral work on
acetaminophen. His research interests focus on the study
of mechanisms underlying the hepatoprotective actions
conferred by a class of compounds known as peroxisome
proliferators. He has published a number of seminal
articles focused on pathways involved in cytoprotection
and is currently evaluating transcriptional regulation of
hepatic transport proteins during liver injury.
AWARDS
Dr. Manautou’s dedication to the training of young
scientists is unmatched. His students speak proudly
of his continued mentorship through daily problem
solving, while allowing them the autonomy and flexibility needed for them to guide the path of their research
projects. In addition to managing his research laboratory,
Dr. Manautou participates on a number of committees
including the National Research Council Committee
on Human Health Risks of Trichloroethylene and the
European Commission Sixth Framework Programme
on Food Quality and Safety on Risk Assessment of
Non-Dioxin-Like Polychlorinated Biphenyls. Also worth
mentioning is Dr. Manautou’s strong commitment to the
Society of Toxicology. Dr. Manautou has been active on
the Placement Committee, Mechanisms Specialty Section,
and Minority Program where he has held a number of
appointments. Most recently, Dr. Manautou served as SOT
Councilor and was active as the Council Liaison to the
Specialty Sections, Education Subcommittee for Minority
Programs, the NIH Funding Task Force, and the Special
Interest Group Task Force.
37
2006 Award Winners (Continued)
45th Annual
Meeting & ToxExpo
potential partners in industry and government. Under
Ms. Mackta’s leadership, the NJABR sponsors an annual
“Thank You Research” month to celebrate the achievements
of people and programs involved in biomedical research.
This program includes a lesson plan that encourages
students to write thank you letters to researchers involved
in an area of biomedical research that has affected them.
Ms. Mackta’s efforts have been instrumental in establishing
the NJABR as a credible resource for providing information for schools and public organizations on the important
and integral role that animals play in biomedical research
including toxicology. Her dedication to fostering awareness
in the community of the importance of animals in toxicology and other areas of biomedical research make her an
excellent choice for the Contributions to Public Awareness
of the Importance of Animals in Toxicology Research Award.
Jodi Flaws, University of Maryland Baltimore
Project Title: Proposal to Develop a Micro-assay for
Culturing Mouse Ovarian Surface Epithelium and Assessing
DNA Adduct Formation
Courtney E.W. Sulentic, Wright State University
Project Title: Modulation of the 3’ Immunoglobulin Heavy
Chair Regulatory Region, a Prospective In Vitro Screening
Tool for Identifying Potential Immunotoxicants
Xiaozhong Yu, University of Washington
Project Title: Validation of an ECM-Overlay-Based 3-D
Sertoli Cell/Gonocyte Co-Cultures System as an In Vitro
Model for Assessment of Male Reproductive Toxicity
Contributions to Public
Awareness of Animal Welfare
Award
Dr. Sten G. Orrenious has made
important contributions to the field
of toxicology over the last 40 years. He
received his Ph.D. in 1965 and his M.S.
in 1967 from the Karolinska Institute
in Stockholm, Sweden. He later was
appointed Professor and Chairman of
the Department of Forensic Medicine
at the Karolinska Insitute and also
became its Dean of Medicine. From
Sten G.
1988-1999, he served as Director
Orrenius
of the Institute of Environmental
Medicine, and subsequently became Professor Emertius
at the Karolinska Institute in 2004. During his tenure
he has contributed over 542 publications related to
cytochrome P-450, mechanisms of cytotoxicity, glutathione and other cellular defense systems, oxidative stress,
calcium signaling, and, most recently, regulation and
mechanisms of cell death. The importance of his contributions is indicated by that fact that he is recognized as
a Highly Cited Researcher by Thomson ISI. Moreover,
he has received numerous professional honors, such as
membership in the Royal Swedish Academy of Sciences,
the Merit Award from EUROTOX, the MRC lectureship
at the 41st Annual Meeting of the Society of Toxicology,
and the first European Cell Death Organization (ECDO)
Career Award for Excellence in Cell Death Research. This
SOT award is granted in recognition of his extensive and
continuing contributions in both research and mentorship to the field of toxicology over the past four decades.
Dr. Orrenius continues to be a major contributor both to
our understanding of oxidative stress and calcium-mediated
cytotoxicity and to promotion of the field of toxicology.
The Contributions to Public Awareness
of the Importance of Animals in
Toxicology
Research
Award
is
presented annually to an individual
(or organization) in recognition of
the contributions made to the public
understanding of the role and importance of experimental animals in
toxicological science.
Jayne
Mackta
The 2006 Award winner, Ms. Jayne
Mackta, is President of the New Jersey
Association for Biomedical Research
(NJABR), an organization that is a well known and widely
heard voice of reason in conveying the importance of
animals in toxicological research to the public. In her role
as President of this organization, Ms. Mackta is an untiring
crusader. Not only is she active in providing public awareness of this issue, she also participates in informing local
and national legislators of the need for government
recognition and appropriate legislation regarding the use
of animals in research. Ms. Mackta accomplishes her goal
of educating the public about the importance of animals
in research through diverse mechanisms. She established
a speakers bureau that links speakers with schools for the
purpose of spreading the message of the value of animals
in all types of research. She developed a variety of programs
including the ASK program that supports teachers who
believe in the importance of using animals in education,
the CLOUT program that educates elective officials to the
importance of using animals in research, and roundtable
discussions that bring together academic scientists with
39
AWARDS
Distinguished Lifetime
Toxicology Scholar Award
45th Annual
Meeting & ToxExpo
to SOT each year to participate in the national meeting
and you are likely to discover that personal support from
Dr. Schatz played a major role. We honor Dr. Schatz with
the 2006 Education Award because of this personal dedication and willingness to foster the development and
career interest of undergraduate and graduate students in
toxicology.
Education Award
The recipient of the 2006 Education
Award is Dr. Robert A. Schatz, Associate
Professor of Toxicology and Director,
Toxicology Program, Bouve � College
of Health Sciences, Northeastern
University. January 2006 will be
Dr. Schatz’s 25th anniversary for toxicology teaching at Northeastern
University! While Dr. Schatz has had a
long-standing interest in studying the
Robert
influence of solvents on the regulation
Schatz
of drug metabolizing enzymes in the
respiratory tract and consequent respiratory toxicity, his
greatest achievement has been the training of both undergraduate and graduate students in toxicology.
Enhancement of Animal
Welfare
AWARDS
Dr. William S. Stokes, Director of
the National Toxicology Program’s
Interagency Center for the Evaluation
of Alternative Toxicological Methods at
the National Institute of Environmental
Health Sciences, is the 2006 recipient
of the Enhancement of Animal Welfare
Award. This award was instituted in
2000 to honor a member of the Society
of Toxicology whose scientific accomWilliam S.
plishments
have lead to a marked
Stokes
reduction in the use of experimental
animals for research. Dr. Stokes is responsible for directing
the scientific evaluation of new chemical and product safety
assessment methodologies that support improved protection of human health and improved animal welfare. He
also administers the Interagency Coordinating Committee
on the Validation of Alternative Methods (ICCVAM),
which reviews test methods of interagency interest and
coordinates related validation, regulatory acceptance, and
national and international harmonization issues within
the Federal government. Dr. Stokes is a Captain in the
Commissioned Corps of the U.S. Public Health Service
(USPHS) and the Chief Veterinary Officer for the USPHS.
In this role, he is responsible for providing leadership and
coordination of Public Health Service veterinary professional affairs for the Office of the Surgeon General and the
Department of Health and Human Services. Dr. Stokes is a
recipient of the NIH Director’s Award and the Russell and
Burch Recognition Award from the Humane Society of the
United States. Dr. Stokes also served as a Council member
for the Institute for Laboratory Animal Research at the
National Research Council, National Academy of Sciences
from 1998-2004. The Society of Toxicology is pleased and
honored to recognize Dr. Stokes’ contributions to marked
reduction in the use of experimental animals for research.
Dr. Schatz began his career by receiving his B.S. in
Pharmacy from the Massachusetts College of Pharmacy
(1966) and Masters in Pharmacology from Northeastern
University (1968). He received his Ph.D. in Pharmacology/
Toxicology from the University of Rhode Island (1971)
after which he was appointed as an NIH post-doctoral
fellow at the Mental Health Research Institute, University
of Michigan. From 1973-1981 he rose through the ranks
and reached the level of Senior Research Associate. In 1981,
Dr. Schatz joined the Toxicology/Pharmacology Program
at Northeastern University. At Northeastern University,
Dr. Schatz quickly assumed leadership positions. From
1985-1988, he served as Acting Director of the Toxicology
Program and was then appointed Director. He also served
as Acting Director, Biomedical Sciences (1988-1990) and
then Director of the Pharmaceutical Sciences Graduate
Program (1999-present). Dr. Schatz has also held numerous
positions in the Society of Toxicology including, most
recently, a member of the Animals in Research Committee
(1998-2002) and Vice President of the Northeast Regional
Chapter of the Society of Toxicology (1998-1999).
Northeastern University has one of the few undergraduate toxicology degree programs in the United States.
This program has been very successful over the years in
producing undergraduate students, numbering in the
100s, who have assumed leadership positions in academia,
government and industry. Dr. Schatz has also trained 19
doctoral students and has served on the thesis committees of many others. The training of this large number of
students from this small toxicology program, with limited
resources and space, is quite an accomplishment. The
success of the Northeastern Toxicology program at both the
undergraduate and graduate levels has been and continues
to be completely dependent on Dr. Schatz’s continuous
perseverance and, often, personal financial support. Ask
any Northeastern University graduate how they traveled
40
45th Annual
Meeting & ToxExpo
Merit Award
Colgate Palmolive—SOT
Awards for Student Research
Training in Alternative
Methods
Mary Hassani, University of Montana
Project Title: NAP(P)H:Quinone Oxidoreductase 1 (NQ01)Directed Lavendamycin Antitumor Agent Development via
Molecular Modeling
Prajakta Palkar, University of Louisiana Monroe
Project Title: Proteomic Analysis to Elucidate the Mechanism
involved in Resiliency of Human RBC’s and New RBC’s from
Primed Rats to BE is Due to Over-Expression of Endogenous
Inhibitors of Hydrolytic Enzymes.
Pfizer Undergraduate Student
Travel Award
Shawntay Chaney, University of Houston
Theresa M. Eagle, Michigan State University
Natalie Malek, Texas A&M University
Adeliada Segarra, University of Puerto Rico Cayey
Ryan Vaughan, University of Connecticut Storrs
The 2006 Novartis Graduate
Fellowship
recipient will be announced at the
Annual Meeting.
41
AWARDS
Dr. A. Wallace Hayes has made
significant contributions to the field
of toxicology through his research
accomplishments, his mentorship of
young scientists, his dedication to the
associated societies and his textbook
contributions. Through his tenure
in both corporate environments and
academic positions, he has been a
contributing author to over 180 peerA. Wallace
reviewed scientific reports and has
Hayes
contributed to the publication of
nine reference books, including Principles and Methods of
Toxicology, which serves as an indispensable guide not
only for those involved in risk assessment but for basic
scientists, clinicians and others. He has given generously
of his time to the Society of Toxicology in roles on many
different committees (Program, Technical, Animals in
Research, Membership and Education) and served on its
Council. In addition, he has served in numerous editorial capacities for journals, including Editor of Toxicology
and Applied Pharmacology. Dr. Hayes is currently editor of
Cutaneous and Ocular Toxicology and editor for the Americas
of Human and Experimental Toxicology. He has served on the
board of Directors, and as Vice-President and President, of
the Academy of Toxicological Scences. His dedication to
education and mentoring is exemplified by his role in
the establishment of the Leon Goldberg Memorial PostDoctoral Fellowship Program for Toxicology at Duke
University. Dr. Hayes has been active as a Board Member
and Officer of the Toxicology Education Foundation.
He has served as a delegate to International Union of
Toxicology (IUTOX) and on several IUTOX commissions.
Dr. Hayes currently is the Secretary-General of IUTOX.
Dr. Hayes has served on committees and expert panels
for the National Academy of Sciences, the National
Institutions of Health, the Environmental Protection
Agency and the Department of Defense as well as on
several international expert panels. Dr. Hayes is a diplomat
of the American Board of Toxicology, the American Board
of Forensic Medicine and the American Board of Forensic
Examiners. He is a Fellow of the Academy of Toxicological
Sciences, the Institute of Biology (UK) and the American
College of Forensic Examiners. Dr. Hayes is a registered
toxicologist in the European Union (ERT). Dr. Hayes is
currently at Harvard School of Public Health. For his past
and continuing contributions, Dr. A. Wallace Hayes is
highly deserving of the Merit Award.
Student Awards:
2005 Student Award Winners
45th Annual
Meeting & ToxExpo
These scientists were selected for Fellowships at the 2005 SOT Annual Meeting. Visit their presentations at this
Meeting to see their outstanding work from their 2005–2006 Fellowship year.
Colgate-Palmolive Post-Doctoral Fellowship in In Vitro Toxicology
Francis Tukov, Michigan State University
2006 Abstract: 1718
Title: Kupffer Cell/Hepatocyte Co-Culture as a Model to Assess XenobioticInflammation Interactions
Francis
Tukov
Novartis Graduate Fellowship
Andrea W. Wong, University of Toronto
2006 Abstract: 1435
Title: The Role of Oxidative DNA Damage and Repair in MethamphetamineInitiated Neurodevelopmental Deficits
Andrea W.
Wong
AWARDS
Visit the SOT Web site for upcoming award
details and deadlines at…
www.toxicology.org
42
45th Annual
Meeting & ToxExpo
Scientific Session Index
General Scientific Sessions
All courses will be held on Sunday, March 5, 2006, at the San
Diego Convention Center. Please check the signage in the
registration area for room assignments. Note: Your course
materials will be available in the room immediately prior
to the course (they will not be available at the Registration
area). If you have your course ticket, go directly to the
assigned course room. If you have not received your course
ticket or have not registered, please go to the Registration
area on Saturday afternoon/evening or on Sunday
morning. If you have misplaced your ticket, please go to the
Continuing Education Booth, Upper Level, at the San Diego
Convention Center on Sunday. The booth will be open from
6:30 AM–5:15 PM. Course descriptions are on pages 49–55.
Registration for the Annual Meeting is required for CE
attendees.
(Listed by type, then date and time.)
Monday
Symposia
Date/Time Topic/Abstract #
Room
Monday
9:30 AM
Lipidomics of Cell Death
#12–16
6E
60
Monday
9:30 AM
Regulation of Phase II
Xenobiotic Metabolizing
Enzymes: Implications
for Health and Disease #17–21
8
60
Monday
9:30 AM
Risk Assessment Implications
of Direct Nose–to–Brain
Transport of Inhaled
Xenobiotics #22–26
5B
61
7:00 AM–7:45 AM, Sunrise Mini–Course:
Page
Workshops
SR01. Use of Genome Databases for Toxicology
8:15 AM–12:00 NOON, Morning Courses
AM02. Targeted Therapeutic Approach to Anti-Cancer Drug
Development
AM03. Reproductive Toxicity Testing: Study Designs,
Evaluation, Interpretation, and Risk Assessment
AM04. Predictive Power of Novel Technologies (Cells to
‘Omics’): Promises, Pitfalls, and Potential Applications
AM05. Comparative Endocrine Toxicology
Room
Page
Monday
9:30 AM
Screening Methods for
Assessing Skin Toxicity of
Nanomaterials #27–31
5A
61
Monday
9:30 AM
Towards the Virtual Human:
Adding More Physiological
Detail to Biologically Based
Models #32–36
2
62
Platform Sessions
AM06. Essentials of Metal Toxicology
AM07. Practical Strategies for Evaluation of
Immunosuppression in Pharmaceutical Development
1:15 PM–5:00 PM, Afternoon Courses
PM08. Targeted Therapeutic Approach to Anti-Cancer Drug
Development
PM09. Reproductive Toxicity Testing: Study Designs,
Evaluation, Interpretation, and Risk Assessment
PM10. Functional Analysis of Gene and Protein Expression:
From Experimental Design to Data Analysis
PM11. Xenobiotic Transporters
Room
Monday
9:30 AM
Alternative Models for
Assessment of Toxicity #37–45
15A
Page
62
Monday
9:30 AM
Frontiers of Neurotoxicology:
Extrapolation and Human
Health #46–51
7B
63
Monday
9:30 AM
Gene Expression Changes in
Carcinogenesis #52–59
1A
63
Monday
9:30 AM
Modulation of Carcinogenesis
by Naturally Occurring
Polyphenolic Compounds
#60–67
7A
64
PM12. Neuropathology for the Toxicologist
SESSION INDEX
PM13. Assessing Airway Injury and Remodeling Induced by
Inhaled Pollutants Using Magnetic Resonance
Imaging, Microscopy, and Modeling
43
45th Annual
Meeting & ToxExpo
Scientific Session Index (Continued)
Poster Sessions
Workshop
*Attended 9:30 AM–11:00 AM; otherwise attended 10:30 AM–12:00 NOON.
Room
Monday
1:30 PM
15A
Monday
9:30 AM
*
Monday
9:30 AM
Monday
9:30 AM
Monday
9:30 AM
Monday
9:30 AM
*
Monday
9:30 AM
Monday
9:30 AM
*
Children’s Health and Juvenile Exhibit Hall 68
Animal Toxicity #109–127
Exhibit Hall 69
Biomarkers #157–193
Exhibit Hall 71
Peroxisome Proliferators/PPAR
#194–207
Exhibit Hall 74
Ah Receptor I #208–228
Exhibit Hall 75
Responses to Particulates
#229–244
Exhibit Hall 77
*
Monday
9:30 AM
Room
Monday
1:30 PM
Ah Receptor II #353–361
7A
Page
88
Monday
1:30 PM
Developmental Toxicity
In Vivo and In Vitro
Investigations #362–370
5A
88
Monday
1:30 PM
Hypersensitivity #371–379
5B
89
Monday
1:30 PM
Risk Assessment—Regulatory/
Policy #380–388
1B
90
*Attended 1:30 PM–3:00 PM; otherwise attended 3:00 PM–4:30 PM.
Immunomodulation #245–288 Exhibit Hall 78
Cardiovascular System:
Valvular and Vascular Injury
#289–310
Exhibit Hall 81
Room
Monday
1:30 PM
Female Reproduction
#389–406
Exhibit Hall 90
Arsenic Toxicology #407–445
Exhibit Hall 92
Kidney #446–477
Exhibit Hall 95
Oxidative Injury Mechanisms
#478–513
Exhibit Hall 97
Genotoxicity/DNA Repair
#514–560
Exhibit Hall 99
Toxicokinetics/
Pharmacokinetics #561–605
Exhibit Hall 102
Safety Evaluation—
Pharmaceuticals 1 (Neuro,
Cardiovascular, Endocrine/
Metabolic) #606–634
Exhibit Hall 105
Respiratory Tract Injury:
Cellular Mechanisms
#635–648
Exhibit Hall 107
Cardiovascular System: ECG
and hERG #649–667
Exhibit Hall 108
Monday
1:30 PM
Date/time
Topic/Abstract #
Room
Monday
1:30 PM
Advancing Toxicology by
Improving Linkage of
Traditional Toxicity and
Pathology Endpoints With
Toxicogenomics #311–316
6F
Monday
1:30 PM
The Biological Matrix of In
Vitro Systems and Their Use in
Toxicology #317–322
7B
Monday
1:30 PM
Indirect Mechanisms of
Toxicity: Advancing Our
Understanding of
Neuroendocrine–Immune
Interactions #323–327
6E
Mode of Action Associated
with Induction of
Endothelial Cell Tumors—
Hemangiosarcoma #328–334
2
Monday
1:30 PM
New Concepts in the
Neurotoxicology of Lead
#335–340
6B
Monday
1:30 PM
New Insights into Mechanisms 8
of Cell Death and Survival
#341–346
*
Monday
1:30 PM
Symposia
Monday
1:30 PM
87
Platform Sessions
Exhibit Hall 66
Developmental Toxicity in
In Vivo and In Vitro Systems
#128–156
Advances in Asbestos
Toxicology and Exposure
Assessment #347–352
Poster Sessions
Monday
9:30 AM
Monday
9:30 AM
Page
Chemical–Biological Weapons I Exhibit Hall 65
#68–81
Persistent Organic Pollutants
#82–108
*
Room
Page
Page
*
Monday
1:30 PM
83
Monday
1:30 PM
*
Monday
1:30 PM
84
Monday
1:30 PM
*
84
Monday
1:30 PM
85
Monday
1:30 PM
SESSION INDEX
Monday
1:30 PM
86
*
Metabolism Toxicity and
Polymorphisms #668–704
Page
Exhibit Hall 110
86
44
45th Annual
Meeting & ToxExpo
Roundtable
Monday
4:30 PM
Room
The Complexities of Air
7A
Pollution Regulation: The
Need for an Integrated Research
and Regulatory Perspective
#705–710
Page
112
Sunset Sessions
Room
Page
Monday
4:30 PM
Distance Learning in
6C
Toxicology: Effective Teaching
Through Technology #711–716
113
Monday
4:30 PM
Toxicology in the Courtroom:
Establishing Causation—A
Roundtable Discussion
#717
113
6F
Roundtables
Room
Tuesday
7:30 AM
The Precautionary Principle—
Implications and Applications
#718–722
2
115
Tuesday
7:30 AM
Research and Development of
Child Specific Protection in
California #723–729
7B
116
Page
Tuesday
9:00 AM
2
Development of Safety
Qualification Thresholds and
Their Use in Drug Product
Evaluation #730–735
118
Tuesday
9:00 AM
Role of Mitochondria in Toxic
Oxidative Stress #741–745
118
Tuesday
9:00 AM
120
Tuesday
9:00 AM
Regulatory Application of the
Mouse LLNA: New Challenges
and Opportunities #769–774
7B
121
Room
Tuesday
9:00 AM
Ah Receptor III #775–783
6C
121
Tuesday
9:00 AM
Biomarkers: Identification and
Application #784–791
15A
122
Tuesday
9:00 AM
Genetic Polymorphisms
#792–800
6F
123
Tuesday
9:00 AM
In Vitro and In Vivo Responses
to Smoke #801–807
7A
123
Room
5B
Room
Tuesday
9:00 AM
Dermatotoxicity #808–847
Exhibit Hall 124
Epidemiology/Exposure
Exhibit Hall 127
Risk Assessment Methods—
Regulatory/Policy #879–918
Exhibit Hall 129
*
*
Tuesday
9:00 AM
Tuesday
9:00 AM
Tuesday
9:00 AM
Page
Tuesday
9:00 AM
119
*
*
*
Tuesday
9:00 AM
45
Page
Developmental Toxicity
Exhibit Hall 131
Testing in Mammalian Systems
#919–947
Tuesday
9:00 AM
119
Tuesday
9:00 AM
Page
Tuesday
9:00 AM
Comprehensive Responses of
1A
Lipids Classes to Toxicants and
Involvement in Diseases
#746–751
Discovery Toxicology:
Strategies in the New
Drug Discovery Paradigm
#752–757
1B
Tuesday
9:00 AM
Workshops
Tuesday
9:00 AM
New Food Ingredients Do Not
Need New Food Regulations
#763–768
Tuesday
9:00 AM
117
Risk Assessment and Regulatory 6E
Implications of Convulsive
Neurotoxicity #736–740
Tuesday
9:00 AM
Page
Tuesday
9:00 AM
8
120
Poster Sessions
Symposia
Room
Page
Does the Methylation of
5A
Inorganic Arsenic Affect its
Toxicity and Mode(s) of Action:
A Critical Discussion #758–762
Platform Sessions
Tuesday
Room
Tuesday
9:00 AM
*
Carcinogenesis Mechanisms
#948–983
Exhibit Hall 134
Bioinformatics #984–998
Exhibit Hall 136
Acetaminophen #999–1010
Exhibit Hall 137
Kinase Signaling #1011–1022
Exhibit Hall 138
Respiratory Tract Irritation,
Infection and Inflammatory
Injury #1023–1044
Exhibit Hall 139
Inorganic Particles and Fumes
#1045–1059
Exhibit Hall 141
Ozone #1060–1070
Exhibit Hall 142
SESSION INDEX
45th Annual
Meeting & ToxExpo
Room
Tuesday
9:00 AM
Toxicogenomics #1071–1094
Exhibit Hall 143
Nervous System: Disease
Models #1095–1115
Exhibit Hall 144
Tuesday
9:00 AM
*
Poster Sessions
Page
Symposia
Room
Tuesday
1:30 PM
Alternative Model Organisms
for the Analysis of
Developmental and Molecular
Toxicology #1116–1121
5B
148
Tuesday
1:30 PM
Role of the Kupffer Cell in
Mediating Hepatic Toxicity
and Carcinogenesis
#1122–1127
6C
149
Tuesday
1:30 PM
Using Structure–Based
Approaches for Hazard
Identification and Risk
8
Tuesday
1:30 PM
The War on Ozone in the 3rd
Millennium: Toxicology and
Health Effects Update
#1134–1139
6F
Room
Tuesday
1:30 PM
Pesticides #1202–1220
Exhibit Hall 156
Hepatocarcinogenesis
#1221–1231
Exhibit Hall 158
Multigeneration Reproductive
Toxicity Evaluations
#1232–1245
Exhibit Hall 159
Biomonitoring #1246–1267
Exhibit Hall 160
Physiologically–Based Models:
Applications #1268–1280
Exhibit Hall 162
Safety Assessment—Methods
and Models #1281–1320
Exhibit Hall 163
Tuesday
1:30 PM
Page
Tuesday
1:30 PM
Tuesday
1:30 PM
Tuesday
1:30 PM
Page
6D
Tuesday
1:30 PM
Genomics in Risk Assessment: 6B
Utility for the Characterization
of Mode of Action #1146–1150
151
Tuesday
1:30 PM
Potential Human Health Risk
from Estrogenic Food and
Consumer Product Additives:
How Much is Real and How
Much is Hype? #1151–1156
152
Tuesday
1:30 PM
151
*
*
Tuesday
1:30 PM
2
Nuclear Receptors #1321–1341 Exhibit Hall 165
Gene Regulation I #1342–1360 Exhibit Hall 167
Tuesday
1:30 PM
Workshops
Dendritic Cells and Skin
Sensitization: Biological
Roles and Uses in Hazard
Identification #1140–1145
*
Tuesday
1:30 PM
150
Tuesday
1:30 PM
*
Tuesday
1:30 PM
149
Room
*
Tuesday
1:30 PM
Tuesday
1:30 PM
*
Page
Gene Regulation II #1361–1386 Exhibit Hall 168
Natural Products #1387–1424
Exhibit Hall 170
Neurotoxicity: Developmental
#1425–1461
Exhibit Hall 173
Neurotoxicity: Pesticides
#1462–1491
Exhibit Hall 176
Wednesday
Symposia
Page
Wednesday
9:00 AM
Gene-Nutrient-Environment6B
Interactions as Risk Factors for
Birth Defects: Fumonisin, Folate,
Genetic Variation and Neural
Tube Defects #1492–1496
179
Wednesday
9:00 AM
Models and Mechanisms of
Occupational/Environmental
Asthma #1497–1502
6F
180
Platform Sessions
Page
Room
SESSION INDEX
Room
Tuesday
1:30 PM
Apoptosis #1157–1165
1B
152
Tuesday
1:30 PM
Endocrine Disruptors—
Mechanisms #1166–1174
15A
153
Wednesday
9:00 AM
Obesity as a Modulator of
6C
Chemical Toxicity #1503–1508
180
Tuesday
1:30 PM
Metals Toxicology I
#1175–1183
7A
154
Wednesday
9:00 AM
The Role of MAP Kinases in
Metal Toxicity #1509–1514
181
Tuesday
1:30 PM
Oxidative Injury #1184–1192
7B
155
Tuesday
1:30 PM
Particulate Matter: Effects and
Mechanisms #1193–1201
5A
155
46
7B
45th Annual
Meeting & ToxExpo
Workshops
Room
Page
Wednesday
9:00 AM
Advanced Technologies and
Approaches for Quantitative
Biological Monitoring and
Modeling for Chemical
Exposures #1515–1520
15A
181
Wednesday
9:00 AM
Thermoregulation and Its
Influence on Toxicity
6E
182
Room
Wednesday
9:00 AM
Cardiovascular Safety
2
183
Wednesday
9:00 AM
Dioxins, PCBs and PBDEs
#1536–1544
1B
183
Wednesday
9:00 AM
Male and Female Reproductive 8
System #1545–1553
184
Wednesday
9:00 AM
Nanoparticle–Induced Toxicity 5A
#1554–1562
185
Room
Wednesday
9:00 AM
Neurotoxicity: Metals—
General #1768–1802
Exhibit Hall 201
Page
Poster Sessions
Wednesday * P450 Expression and
9:00 AM
Regulation #1803–1835
Exhibit Hall 203
Room
Wednesday
1:30 PM
The Bases for Inter–Individual
Differences in Susceptibility to
Allergic Disease #1836–1841
6E
207
Wednesday
1:30 PM
Determinants of Manganese
6A
Neurotoxicity: From Worms to
Man #1842–1847
207
Wednesday
1:30 PM
Mechanisms of Low Solubility
Particle-Induced Lung Tumors
#1848–1853
1B
208
Wednesday
1:30 PM
The Path for Assessing Human 6C
Relevance and Advancing New
Safety Biomarkers for Drug
Induced Vascular Injury
#1854–1859
208
Wednesday
1:30 PM
Role of Epigenetics in the Fetal 5A
Basis of Adult Disease
#1860–1864
209
Room
Wednesday * Ecotoxicology #1563–1587
9:00 AM
Exhibit Hall 186
Wednesday
9:00 AM
Exhibit Hall 188
Alternative Models for
Assessment of Ocular and
Dermal Toxicity #1588–1601
Page
Wednesday * Risk Assessment I #1602–1641
9:00 AM
Exhibit Hall 189
Wednesday
9:00 AM
Exhibit Hall 191
Carcinogenesis—Modulation
#1642–1657
Wednesday * Disease and Toxicity
9:00 AM
Biomarkers #1658–1671
Exhibit Hall 192
Wednesday
9:00 AM
Exhibit Hall 193
Safety Assessment—
Pharmaceuticals 2 (Oncology,
Anti–Inflammatory,
Anti–Infectives, Excipients,
Natural Products) #1672–1693
Page
Symposia
Platform Sessions
Page
Workshops
Room
Wednesday
1:30 PM
Hormesis: A Challenge to the
Linear Dose–Response Model,
and its Implications in Risk
Assessment, Regulatory Policy,
and Biomedical Research
#1865–1870
8
Wednesday
1:30 PM
Integrating Biomonitoring into 7A
Epidemiology and Toxicology
Research #1871–1875
Page
210
210
Platform Sessions
Room
Page
Wednesday
1:30 PM
Biotransformation #1876–1884 7B
211
Wednesday * Inhalation Methods and
9:00 AM
Dosimetry #1694–1705
Exhibit Hall 195
Wednesday
1:30 PM
Bioinformatics and Biological
Modeling #1885–1892
15A
211
Wednesday
9:00 AM
Exhibit Hall 196
Wednesday
1:30 PM
Immunotoxicity #1893–1901
5B
212
Wednesday * In Vitro Immunotoxicity
9:00 AM
#1718–1736
Exhibit Hall 197
Wednesday
1:30 PM
Predicting Compound
Toxicity #1902–1909
2
213
Wednesday
9:00 AM
Exhibit Hall 198
Liver I #1706–1717
Methods in Immunotoxicity
#1737–1750
Wednesday * Neurotoxicity: Metals—
9:00 AM
Manganese #1751–1767
Exhibit Hall 199
47
SESSION INDEX
45th Annual
Meeting & ToxExpo
Poster Sessions
Symposia
Room
Thursday
9:00 AM
Air Pollution: Vanguard
Toxicological Approaches
Considering Atmospheric
Aging #2210–2215
2
237
Thursday
9:00 AM
Application of Genomics to
Evaluating Mechanisms of
Genotoxicity and
Carcinogenicity #2216–2221
8
238
Thursday
9:00 AM
Idiosyncratic Hepatotoxicity:
Non–Clinical Predictive
Toxicology for Liver Injury
Potential #2222–2226
6D
239
Thursday
9:00 AM
Metabonomics: Moving
Beyond the Profile
#2227–2231
5B
239
Thursday
9:00 AM
Obesity: Developmental
Origins and Environmenal
Influences #2232–2237
7B
240
Room
Wednesday * Chemical–Biological
1:30 PM
Weapons II #1910–1927
Exhibit Hall 213
Wednesday
1:30 PM
Exhibit Hall 215
Endocrine Disruptors
#1928–1954
Page
Wednesday * Alternatives to Mammalian
1:30 PM
Models #1955–1976
Exhibit Hall 217
Wednesday
1:30 PM
Exhibit Hall 218
Food Safety and Nutrition
#1977–2001
Wednesday * Cell Death/Apoptosis
1:30 PM
#2002–2021
Exhibit Hall 220
Wednesday
1:30 PM
Exhibit Hall 222
CD Toxicity, Zinc, and
Metallothionein #2022–2042
Wednesday * Metals Toxicology II
1:30 PM
#2043–2082
Exhibit Hall 223
Wednesday
1:30 PM
Exhibit Hall 226
Carcinogenesis Bioassay
#2083–2095
Wednesday * Male Reproductive Toxicity
1:30 PM
Evaluations #2096–2114
Wednesday
1:30 PM
Computational Toxicology
#2115–2128
Exhibit Hall 229
Exhibit Hall 230
Wednesday
1:30 PM
Exhibit Hall 231
Cardiovascular System:
Cardiotoxicity #2151–2179
Wednesday * Risk Assessment—Metals
1:30 PM
#2180–2202
Workshops
Exhibit Hall 227
Wednesday * Liver II #2129–2150
1:30 PM
Room
Thursday
9:00 AM
Immunotoxicity Evaluation
by Immune Function Tests
#2238–2242
5A
240
Thursday
9:00 AM
Pharmaceuticals in the
7A
Environment: Leveraging
Mammalian Data in
Determining Human
Pharmaceutical Responses in
Aquatic Vertebrates #2243–2248
241
Exhibit Hall 233
Page
Poster Sessions
Roundtables
Room
Wednesday
4:30 PM
Food Safety and Security:
Regulatory and Industry
Safeguards #2203–2207
5A
235
Wednesday
4:30 PM
U.S. EPA’s 2005 Cancer
Guidelines #2208
5B
235
Page
Thursday
Historical Highlight
SESSION INDEX
Thursday
8:00 AM
Page
Room
Historical Highlight:
7B
Organophosphates from Nerve
Gas to Insecticide #2209
Page
237
48
Room
Page
Thursday *
9:00 AM
Hypersensitivity: Mechanisms
and Methods #2249–2283
6A
242
Thursday
9:00 AM
Risk Assessment II #2284–2320 6A
244
Thursday *
9:00 AM
Safety Evaluation—
Non-Pharmaceutical
#2321–2348
6A
246
Thursday
9:00 AM
Biomarkers: Methods & Tools
#2349–2364
6A
248
Thursday *
9:00 AM
Physiologically–Based Models:
Development and Evaluation
#2365–2383
6A
249
Thursday
9:00 AM
Analytical Toxicology
#2384–2391
6A
251
Thursday *
9:00 AM
Liver III #2392–2410
6A
251
Thursday
9:00 AM
Nervous System: Mechanisms
and Effects #2411–2442
th
6A
253
SOT's 45 Annual Meeting
45th Annual
Meeting & ToxExpo
TARGETED THERAPEUTIC APPROACH TO ANTI-CANCER
DRUG DEVELOPMENT
The Continuing Education Program offers a wide range of courses
that cover state-of-the-art knowledge in toxicology, as well as new
developments in toxicology and related disciplines. Courses can be
applied toward certifying and licensing board requirements and may
also be used for recertification with the American Board of Toxicology (ABT). Both basic and advanced course topics are offered.
The basic course is intended to provide a broad overview of an area
or to assist individuals in learning new techniques or approaches.
The advanced course is intended to be of interest to individuals with
previous knowledge of the subject or already working in the field.
AM 02 (REPEATS AS PM 08)
Endorsed by:
Comparative and Veterinary SS
Regulatory and Safety Evaluation SS*
Over the past decade, a range of targeted anti-cancer drugs have been
developed that are designed to interfere with one or more of the many
molecular mechanisms that drive tumor growth. The molecularly-targeted
approach to the development of these new anti-cancer drugs has created a
false impression that these newer drugs, unlike earlier cytotoxic anti-cancer
drugs, will be non-toxic. Cytotoxic drugs are typically administered in
short courses of maximal doses (MTD). This is not necessarily appropriate for targeted therapies, which can require long-term therapy and
for which it is often difficult to determine the biologically most effective
dosage (BED). This course will focus on different aspects of regulatory,
pre-clicical, and clinical targeted anti-cancer drug development. The first
speaker will focus on tumor cell biology and the respective cell signaling
pathways that hold promise for targeted anti-cancer therapy. The second
speaker will present differences in pre-clinical development philosophy
between cytotoxic and targeted anti-cancer drugs. The third speaker
will discuss specific examples of pre-clinical development of targeted
biotherapeutics. The fourth speaker will discuss biomarkers as endpoints
of clinical efficacy and safety assessment. The final speaker will focus on
regulatory considerations of pre-clinical development of targeted therapies,
highlighting differences between cytotoxic and targeted therapies. This
advanced course in drug development is targeted to government, biotechnology and pharmaceutical toxicologists as well as general toxicologists
with an interest in cancer chemotherapy.
*The Primary Specialty Section (SS) or Regional Chapter (RC) Endorser
USE OF GENOME DATABASES FOR TOXICOLOGY
BASIC
Chairperson(s): William B. Mattes, Gene Logic Inc., Gaithersburg, MD.
Endorsed by:
Mechanisms SS
National Capital Area RC
Molecular and genomic information is increasingly an important part of all
biological research including toxicology. While toxicologists often focus
on data from microarray-based expression profiles, other molecular data,
including the organization and function of genes in the context of the cell,
the physical genome and sequence, and the relationships between species
in terms of this organization, can provide important insights. Therefore
facilities with public molecular biology databases and search tools are
essential to all toxicologists. Moreover, the recent availability of complete
genomes, including the human, mouse and rat, has made genome-wide
queries and comparative genomics readily accessible to all researchers
and has the potential to revolutionize medical research and practice. The
largest public repository of biological sequence information is maintained
by the National Center for Biotechnology Information (NCBI) at the
National Library of Medicine. This course will describe the molecular
database resources, including sequences, structures and genomes, and the
tools available through the WWW interface to the NCBI. The discussion
will then focus on using these tools and databases as well as the specialized genomic resources. The Entrez and BLAST Web services will be
demonstrated and how both can be used as a biological discovery system in
toxicology will be illustrated. This tutorial is intended as an overview and
introduction of NCBI genomic and molecular databases to toxicologists,
but even experienced users will find it helpful.
•
Use of Genome Databases for Toxicology, Peter S. Cooper, NCBI
User Services, National Library of Medicine, Bethesda, MD.
ADVANCED
Chairperson(s): Vijayapal Reddy, Eli Lilly & Company, Greenfield, IN and
Myrtle A. Davis, Eli Lilly & Company, Greenfield, IN.
Please Note: Each Continuing Education Course is offered in one of
three time blocks: Sunrise (7:00 AM–7:45 AM), AM (8:15 AM–12:00
NOON) or PM (1:15 PM–5:00 PM). Registration for the Annual Meeting
is required. See signage in Lobby 6 Ballroom Foyer for room locations.
SUNRISE MINI-COURSE 1
CE
Continuing Education
49
•
Identification, Pharmacologic Expectations and Toxicological
Considerations for Targeted Therapies, Myrtle A. Davis, Eli Lilly
& Company, Greenfield, IN.
•
The Development of Cytotoxics to MTD and Targeted Drugs
to BEDs: Is this the Correct Paradigm? Joseph E. Tomaszewski,
National Cancer Institute, Rockville, MD.
•
Pre-clinical Safety Evaluation of Anti-Cancer Biotherapeutics,
Joseph Beyer, Toxicology & Pathology, Genetech, Inc., South San
Francisco, CA.
•
Targeted Efficacy and Targeted Toxicity: Are the Biomarkers the
Same? Kerry L. Blanchard, Eli Lilly & Company, Greenfield, IN.
•
Regulatory Considerations for Non-Clinical Development of AntiCancer Drugs, John K. Leighton, U.S. FDA, Rockville, MD.
45th Annual
Meeting & ToxExpo
CE
Continuing Education (Continued)
REPRODUCTIVE TOXICITY TESTING: STUDY DESIGNS,
EVALUATION, INTERPRETATION, AND RISK ASSESSMENT
AM 03 (REPEATS AS PM 09)
PREDICTIVE POWER OF NOVEL TECHNOLOGIES (CELLS
TO ‘OMICS’): PROMISES, PITFALLS, AND POTENTIAL
APPLICATIONS
BASIC
AM 04
Chairperson(s): Donald G. Stump, WIL Research Laboratories, LLC,
Ashland, OH.
Chairperson(s): Srikanth S. Nadadur, U.S. EPA, Research Triangle Park,
NC and Mary Jane Cunningham, Houston Advanced Research Center, The
Woodlands, TX.
Endorsed by:
Regulatory and Safety Evaluation SS
Reproductive and Developmental Toxicology SS*
Risk Assessment SS
Endorsed by:
Inhalation SS*
Molecular Biology SS
Toxicologic & Exploratory Pathology SS
This course is intended to provide a general overview for scientists responsible for the design, conduct and monitoring of reproductive toxicity
studies. The course will focus on reproductive biology, study design
considerations, reproductive endpoints, data interpretation and use of
data in risk assessment. Reproductive toxicity studies are among the most
complex and challenging studies in the field of toxicology. The studies
assess multiple interrelated endpoints of male and female reproductive
function. In order to properly design, conduct and interpret these studies, a
fundamental knowledge of male and female reproductive system development, anatomy, physiology, and endocrinology are required. This course
will discuss the designs of reproductive studies for regulatory submission. Individual lectures will discuss the anatomy and physiology of the
male and female reproductive systems as well as endocrine regulation of
these systems. Evaluation of toxicity endpoints to assess male and female
reproductive function will also be discussed including mating, fertility,
estrous cyclicity, spermatogenesis, sexual behavior, parturition, reproductive hormone analysis, nesting and nursing behavior, reproductive organ
weights and histopathology, and proper use of statistical analysis. The
course will conclude with discussions on some common issues related
to reproductive toxicity testing, interpretation of results, and how these
results are ultimately used to assess potential risks to human reproduction.
In summary, this course will present the key information required for the
design of reproductive toxicity studies and interpretation of reproductive
toxicity data and provide guidance for use of the data for risk assessment of
human reproduction.
•
Advances in the disciplines of cell and molecular biology have led to
the development of novel biotechnologies capable of generating “global
molecular profiles” for in situ toxicological assessment. These technologies should accelerate our understanding of molecular basis for potential
toxicity and susceptibility. This course will provide both theoretical and
practical information on these emerging high throughput technologies, their
applicability, interpretation and integration to gain a more comprehensive
understanding of cellular responses to chemical/toxicant stress. The first
presentation will cover the potential utility of Laser Capture Micro-Dissection in isolating specific cell populations for toxicological assessment at
the level of RNA and proteins. The second presentation will provide the
ongoing evolution of gene expression profiling approaches from “toxicogenomics” to systems biology. The third presentation will provide an
overview of proteomic technologies in analyzing the protein interactions
and downstream signaling mediators involved in toxic response pathways.
The final presentation will examine the capabilities of high throughput
technologies in identifying the single nucleotide polymorphisms (SNPs)
and their predictive value for characterizing underlying genetic susceptibilities to toxicants. Overall the course is aimed at educating toxicologists on
the array of new technologies available to research toxic outcomes and their
underlying mechanisms. The goal is to move towards a better and reliable
prediction and extrapolation of toxic responses. This course will also serve
as a refresher course for scientists, technical and regulatory staff involved
in various stages of compound development or regulation.
Reproductive Toxicity Testing: Study Designs and General
Considerations, Barry S. McIntyre, Schering Plough Research
Institute, Lafayette, NJ.
•
Male Reproduction: Biology and Toxicity Endpoints, Kok Wah Hew,
Purdue Pharma LP, Ardsley, NY.
•
Female Reproduction: Biology and Toxicity Endpoints, Christopher
J. Bowman, WIL Research Laboratories, LLC, Ashland, OH.
•
Reproductive Toxicity Testing: Data Interpretation and Risk
Assessment, Rochelle W. Tyl, RTI International, Research Triangle
Park, NC.
BASIC
50
•
Integrating Transgenic Animal Models and Laser Capture
Microdissection Applications with ‘Micro-omic’-Based Analyses for
In Vivo Toxicological Assessments, Kevin L. Dreher, NHEERL, U.S.
EPA, Research Triangle Park, NC.
•
Gene Expression Profiling for Toxicity Assessment Using Systems
Biology, Mary Jane Cunningham, Houston Advanced Research
Center, The Woodlands, TX.
•
Clinical Proteomics: Mapping Molecular Networks in Clinical
Specimens Using Reverse Phase Protein Microarrays, Emanuel F.
Petricoin, George Mason University, Manassas, VA.
•
Common DNA Variation in Human Disease and Drug Response,
Steven Hamilton, University of California, San Francisco, San
Francisco, CA.
45th Annual
Meeting & ToxExpo
COMPARATIVE ENDOCRINE TOXICOLOGY
AM 05
CE
ESSENTIALS OF METAL TOXICOLOGY
BASIC
AM 06
BASIC
Chairperson(s): Stephen B. Hooser, Purdue University, West Lafayette, IN
and Charles C. Capen, The Ohio State University, Columbus, OH.
Chairperson(s): Wei Zheng, Purdue University, West Lafayette, IN and
Michael P. Waalkes, NIEHS, Research Triangle Park, NC.
Endorsed by:
Comparative and Veterinary SS*
Reproductive and Developmental Toxicology SS
Toxicologic & Exploratory Pathology SS
Endorsed by:
Mechanisms SS
Metals SS*
Neurotoxicology SS
Risk Assessment SS
Hormones secreted by cells of the endocrine system have diverse effects
throughout the body. Exposure to xenobiotic compounds can result in
profound changes to the endocrine organs and/or their target cells. Significant species differences exist in the structure and function of endocrine and
reproductive organs making interpretation of test results and extrapolation from animal models to humans more challenging. In addition to the
numerous anatomical and physiological differences, there are also species
variations in metabolism and response to toxicants. It is the goal of these
presentations to give an overview of the structure, function, regulation, and
toxic responses of selected endocrine and reproductive organs. In addition, the speakers will discuss the hormonal assays and other mechanistic
approaches necessary to make species comparisons, and to extrapolate
the findings from animals to humans. Each presentation will briefly
describe important species differences with regard to anatomy, endocrine
physiology, and response to different classes of xenobiotic chemicals by
selected endocrine and reproductive organs such as the thyroid (follicular
cells), ovary, and testis (Leydig cells). One presentation will focus on the
principles and pitfalls of hormonal measurements in laboratory animals
considering advantages/disadvantages of different methods, species specificity of certain assays, most appropriate sampling times, and other useful
items to consider in future protocol development. Following completion of
this workshop, attendees should have a more complete understanding of
the comparative endocrinology and toxicology of selected endocrine and
reproductive organs in laboratory animals.
•
Comparative Endocrine Toxicology of the Thyroid Gland, Charles
C. Capen, The Ohio State University, Columbus, OH.
•
Comparative Ovarian Toxicology, Jodi Flaws, University of
Maryland, Baltimore, MD.
•
Comparative Endocrinology and Toxicology of Testicular Leydig
Cells, Jon C. Cook, Pfizer, Inc., Groton, CT.
•
Principles and Pitfalls of Hormone Measurements in Toxicology
Studies, Terry M. Nett, Colorado State University, Fort Collins, CO.
Metals are ubiquitously present in environment, essential to human health,
and yet toxic upon overexposure. They are neither synthesized by living
matter nor destroyed by human endeavour. Metals play a significant role in
many human diseases. Unique physical, chemical and biological properties
allow metals to persist in the body, cause long-lasting effects, and yet leave
few choices for therapeutic intervention. A fundamental question remains,
namely what makes metals toxic in promoting carcinogenesis, neurotoxicity, reproductive, liver and kidney injuries, or generalized metabolic
disease? This basic course is intended to address the essentials in metal
toxicology by providing cutting-edge knowledge on the concepts, theories,
clinical outcome, and research methodologies in metal toxicology. The
first lecture will highlight the clinical symptoms of metal-induced human
diseases, common routes of exposure, and therapeutic intervention. Two
subsequent lectures will address metal pharmacokinetics and the general
mechanisms of metal-induced cell death, specifically apoptosis. The final
lecture will discuss animal models, based on either symptomatic outcomes
or biochemical consequences, for studying metal toxicities. Speakers will
address these essentials by providing details specific to “hot” metals, such
as arsenic, mercury, manganese, lead, and uranium. The course will serve
as an introduction to those who desire an expanded knowledge on essentials of metals in human health and diseases, essentials of toxicological
actions of metals, and essentials of research approaches in metal toxicological investigation. The course will also be of interest to others engaged
in wider aspects of carcinogenesis, neurotoxicology, risk assessment, and
occupational health.
51
•
Metals in Human Diseases: Symptoms and Clinical Intervention,
Wei Zheng, Purdue University, West Lafayette, IN.
•
Distribution of Metals: Role of Metal Transporters and Selectivity
of Disposition, Michael Aschner, Vanderbilt University, Nashville,
TN.
•
Molecular Mechanism of Metal Toxicity: Signal Transduction and
Oxidative Stress, Anumantha Kanthasamy, Iowa State University,
Ames, IA.
•
Animal Models Used in Metal Toxicological Research, Janelle
Crossgrove, Purdue University, West Lafayette, IN.
45th Annual
Meeting & ToxExpo
CE
PRACTICAL STRATEGIES FOR EVALUATION OF
IMMUNOSUPPRESSION IN PHARMACEUTICAL
DEVELOPMENT
AM 07
TARGETED THERAPEUTIC APPROACH TO ANTI-CANCER
DRUG DEVELOPMENT
PM 08 (REPEAT OF AM 02)
BASIC
Chairperson(s): Vijayapal Reddy, Eli Lilly & Company, Greenfield, IN and
Myrtle A. Davis, Eli Lilly & Company, Greenfield, IN.
Chairperson(s): Brian G. Short, Allergan, Inc., Irvine, CA.
Endorsed by:
Immunotoxicology SS
Toxicologic & Exploratory Pathology SS*
Endorsed by:
Over the past decade, a range of targeted anti-cancer drugs have been
developed that are designed to interfere with one or more of the many
molecular mechanisms that drive tumor growth. The molecularly-targeted
approach to the development of these new anti-cancer drugs has created a
false impression that these newer drugs, unlike earlier cytotoxic anti-cancer
drugs, will be non-toxic. Cytotoxic drugs are typically administered in
short courses of maximal doses (MTD). This is not necessarily appropriate for targeted therapies, which can require long-term therapy and
for which it is often difficult to determine the biologically most effective
dosage (BED). This course will focus on different aspects of regulatory,
pre-clinical, and clinical targeted anti-cancer drug development. The first
speaker will focus on tumor cell biology and the respective cell signaling
pathways that hold promise for targeted anti-cancer therapy. The second
speaker will present differences in pre-clinical development philosophy
between cytotoxic and targeted anti-cancer drugs. The third speaker
will discuss specific examples of pre-clinical development of targeted
biotherapeutics. The fourth speaker will discuss biomarkers as endpoints
of clinical efficacy and safety assessment. The final speaker will focus on
regulatory considerations of pre-clinical development of targeted therapies,
highlighting differences between cytotoxic and targeted therapies. This
advanced course in drug development is targeted to government, biotechnology and pharmaceutical toxicologists as well as general toxicologists
with an interest in cancer chemotherapy.
Increased focus has been placed on evaluating immunotoxicity, particularly
immunosuppression, in pharmaceutical development of small molecules
and biologics following recent issuance of regulatory guidelines from
FDA and CPMP and current ICH discussions on harmonization. Toxicologists, pathologists, immunologists and clinicians in the drug industry are
faced with the challenge of addressing the intent of the current guidance
documents in a scientifically valid and responsible manner. An integrated
approach is necessary to provide a weight of evidence for signal detection
in routine toxicity studies as well as conducting immunotoxicity studies
or adding endpoints in routine toxicity studies to assess immunophenotyping or functional immune alterations. The toxicologist is also central
in communicating the risk to clinicians and regulators following interpretation of non-clinical immunotoxicology data and participating in the
search for clinical immune biomarkers to ensure clinical safety of trial
participants. The goal of this course is to discuss regulatory guidance and
use case examples to illustrate the integration of toxicology, pathology and
immunology in addressing both recent scientific advances and practical
approaches in the pharmaceutical company setting and how this knowledge impacted clinical trials and labeling, with a focus on drug-induced
immunosuppression. Similarities and differences in FDA and CPMP
immunotoxicity guidance documents and recent progress in ICH harmonization will be discussed. Signal detection, including data from standard
toxicity studies and the controversies among toxicologists and pathologists in following the guidelines will be addressed, including the recently
drafted Best Practice Guideline for the Routine Pathology of the Immune
System by the STP Immunotoxicology Working Group. Immunophenotyping conducted by flow cytometry or lymphoid immunohistochemistry
will cover recent advances with case studies. Functional assays, such as
T-cell dependent antibody response, natural killer cell activity, host resistance macrophage/neutrophil function, and cell-mediated immunity will
be discussed with regard to design and timing in drug development from
an immunotoxicologists perspective. Finally, interpretation of non-clinical
immunotoxicology data for risk assessment in clinical trials and use of
clinical immune biomarkers will be featured.
•
Immunotoxicology: What’s New on the ICH Harmonization
Front? Kenneth L. Hastings, CDER Office of New Drugs, U.S. FDA,
Rockville, MD.
•
Immunosuppression Signal Detection in Standard Toxicity Studies
and Immunophenotyping: A Pathologist’s Approach, Patrick J.
Haley, AstraZeneca, Wilmington, DE.
•
Assay to Assay: Functional Evaluation of Imunosuppression, Danuta
J. Herzyk, GlaxoSmithKline, King of Prussia, PA.
•
Clinical Viewpoint: Interpretation of Non-Clinical Immunotoxicity
Data, Human Risk Assessment and Clinical Immune Biomarkers, Ian
Gourley, Lilly Research Laboratories, Indianapolis, IN.
ADVANCED
52
•
Identification, Pharmacologic Expectations and Toxicological
Considerations for Targeted Therapies, Myrtle A. Davis, Eli Lilly
•
The Development of Cytotoxics to MTD and Targeted Drugs
to BEDs: Is this the Correct Paradigm? Joseph E. Tomaszewski,
National Cancer Institute, Rockville, MD.
•
Pre-clinical Safety Evaluation of Anti-Cancer Biotherapeutics,
Joseph Beyer, Toxicology & Pathology, Genetech, Inc., South San
Francisco, CA.
•
Targeted Efficacy and Targeted Toxicity: Are the Biomarkers the
Same? Kerry L. Blanchard, Eli Lilly & Company, Greenfield, IN.
•
Regulatory Considerations for Non-Clinical Development of AntiCancer Drugs, John K. Leighton, U.S. FDA, Rockville, MD.
45th Annual
Meeting & ToxExpo
REPRODUCTIVE TOXICITY TESTING: STUDY DESIGNS,
EVALUATION, INTERPRETATION, AND RISK ASSESSMENT
PM 09 (REPEAT OF AM 03)
CE
FUNCTIONAL ANALYSIS OF GENE AND PROTEIN
EXPRESSION: FROM EXPERIMENTAL DESIGN TO DATA
ANALYSIS
BASIC
PM 10
Chairperson(s): Donald G. Stump, WIL Research Laboratories, LLC,
Ashland, OH.
ADVANCED
Chairperson(s): Richard S. Pollenz, University of South Florida, Tampa,
FL.
Endorsed by:
Reproductive and Developmental Toxicology SS*
Risk Assessment SS
Endorsed by:
Mechanisms SS*
The mechanistic analysis of cellular responses to xenobiotics requires the
functional characterization of changes in both gene and protein expression. The ability to study changes to both genes and proteins in vitro and
in vivo has become accessible to more laboratories with the development
of molecular tools such as microarrays, siRNA, recombinant protein
expression, and viral gene delivery. However, the ability to utilize these
techniques and generate reproducible results requires a detailed understanding of each procedure. Thus, the goal of this course is to provide
the investigator with an overview of experimental design and the use of
proper controls for four cutting-edge techniques. The first talk will focus
on experimental design and analysis of gene expression studies utilizing
microarrays. The second presentation will discuss recent advances in the
chomatin-immunoprecipitation (ChIP) assay for the analysis of protein
interactions at the level of DNA. The third presentation will discuss gene
delivery into hepatocytes in vivo utilizing the adenovirus system. Finally,
the last presentation will discuss the advantages and disadvantages of
recombinant protein expression in cultured cells with emphasis on the
level and functionality of the expressed protein and the use of siRNA. The
course will be of broad interest to those laboratories considering contemporary mechanistic approaches to gene and protein expression as well as
those currently investigating these endpoints.
This course is intended to provide a general overview for scientists responsible for the design, conduct, and monitoring of reproductive toxicity
studies. The course will focus on reproductive biology, study design
considerations, reproductive endpoints, data interpretation, and use of
data in risk assessment. Reproductive toxicity studies are among the most
complex and challenging studies in the field of toxicology. The studies
assess multiple interrelated endpoints of male and female reproductive
function. In order to properly design, conduct and interpret these studies, a
fundamental knowledge of male and female reproductive system development, anatomy, physiology, and endocrinology are required. This course
will discuss the designs of reproductive studies for regulatory submission. Individual lectures will discuss the anatomy and physiology of the
male and female reproductive systems as well as endocrine regulation of
these systems. Evaluation of toxicity endpoints to assess male and female
reproductive function will also be discussed including mating, fertility,
estrous cyclicity, spermatogenesis, sexual behavior, parturition, reproductive hormone analysis, nesting and nursing behavior, reproductive organ
weights and histopathology, and proper use of statistical analysis. The
course will conclude with discussions on some common issues related
to reproductive toxicity testing, interpretation of results, and how these
results are ultimately used to assess potential risks to human reproduction.
In summary, this course will present the key information required for the
design of reproductive toxicity studies and interpretation of reproductive
toxicity data and provide guidance for use of the data for risk assessment of
human reproduction.
•
Design and Analysis of Microarray Experiments, Thomas Sutter,
Feinston Center for Genomic Research, University of Memphis,
Memphis, TN.
•
•
Reproductive Toxicity Testing: Study Designs and General
Considerations, Barry S. McIntyre, Schering Plough Research
Institute, Lafayette, NJ.
Analysis of Protein−DNA Interactions Using Chromatin−Immunop
recipitation (ChIP), Eli Hestermann, Furman University, Greenville,
SC.
•
•
Male Reproduction: Biology and Toxicity Endpoints, Kok Wah Hew,
Purdue Pharma LP, Ardsley, NY.
Adenovirus−Mediated Gene Delivery to Alter Protein Expression In
Vivo, Cornelis Elferink, UTMB, Galveston, TX.
•
•
Female Reproduction: Biology and Toxicity Endpoints, Christopher
J. Bowman, WIL Research Laboratories, LLC, Ashland, OH.
Basics of Recombinant Protein Expression and RNA Interference
in Cultured Cells, Richard S. Pollenz, University of South Florida,
Tampa, FL.
•
Reproductive Toxicity Testing: Data Interpretation and Risk
Assessment, Rochelle W. Tyl, RTI International, Research Triangle
Park, NC.
53
45th Annual
Meeting & ToxExpo
CE
XENOBIOTIC TRANSPORTERS
PM 11
NEUROPATHOLOGY FOR THE TOXICOLOGIST
BASIC
PM 12
BASIC
Chairperson(s): Douglas A. Keller, Sanofi-Aventis, Malvern, PA and
Curtis D. Klaassen, University of Kansas Medical Center, Kansas City, KS.
Chairperson(s): David C. Dorman, CIIT Centers for Health Research,
Research Triangle Park, NC.
Endorsed by:
Drug Discovery Toxicology SS*
Endorsed by:
Neurotoxicology SS
Toxicologic & Exploratory Pathology SS*
Toxicologists have traditionally considered that chemicals are absorbed
and distributed throughout the body largely due to their lipid solubility and
diffusivity through cell membranes. We also consider drug metabolism
as a process that makes chemicals more water soluble so they will less
readily pass cell membranes and be more rapidly excreted. However, it was
not understood how the water-soluble metabolite could exit the cell to be
excreted. During the last decade a number of transporters have been identified that not only are responsible for the excretion of chemicals, but also
for the absorption and distribution of xenobiotics. This course, highlighting
the progress made in this research field as both timely and of significant
interest to a large number of SOT members who are in academic, government and industrial sectors. This course will give an overview of the
families of transporters involved in absorption, distribution and excretion
of drugs and chemicals, as well as presentations specific to the major
tissues where transporters are known to influence toxicity. The roles of
transporters in disposition and toxicity in the liver, kidney, intestine, and
brain will be discussed.
•
Overview of the Families of Transporter Responsible for the
Absorption, Distribution, and Excretion of Drugs, Curtis D.
Klaassen, University of Kansas Medical Center, Kansas City, KS.
•
An Introduction to the Nervous System, David C. Dorman, CIIT
Centers for Health Research, Research Triangle Park, NC.
•
Importance of Renal Transporters in Chemical Disposition and
Toxicity, John B. Pritchard, NIEHS, Research Triangle Park, NC.
Practical Methods in Rodent Neuropathology, Mark T. Butt,
Pathology Associates, Frederick, MD.
•
Clinical and Pharmacological Implications of Transporters in the
Intestine and Blood-Brain Barrier, Jashvant D. Unadkat, University
of Washington, Seattle, WA.
Oh, My Aching Head: Toxicant-Induced Neuropathology of the
Central Nervous System, Brad Bolon, GEMpath Inc., Cedar City,
UT.
•
Morphologic Assessment of the Peripheral Nervous System,
William M. Valentine, Vanderbilt University, Nashville, TN.
•
Quantitative Morphology in Rodent Neuropathology, Karl Jensen,
U.S. EPA, Research Triangle Park, NC.
• Pharmacological and Toxicological Significance of Hepatic
Transporters, Bruno Hagenbuch, University of Kansas Medical
Center, Kansas City, KS.
•
•
This course is designed to provide a basic overview of rodent neuropathology. The course will start off with a review of the normal anatomy
and histology of the adult nervous system. This overview will also discuss
the ways in which neuropathology and functional assays of motor activity
and other behaviors relate to one another. The second lecture relates to
tissue handling techniques and basic approaches in neuropathology. This
topic is critically important since the ability to detect chemical-induced
neuropathology requires proper tissue fixation and processing. Although
the second lecture will largely focus on rodent tissues, the approaches and
methods to be discussed can be easily adapted to other species. The course
will then transition into two presentations focused on common lesions
induced by model neurotoxicants. One presentation will focus on central
nervous system effects while the latter lecture will address peripheral
neuropathies. Our final presentation will discuss morphometric approaches
in neuropathology including a discussion of the use of magnetic resonance
imaging methods in neurotoxicologic pathology. Participants in this course
will gain a greatly improved appreciation of basic neuropathology and
applications to toxicology.
54
ASSESSING AIRWAY INJURY AND REMODELING INDUCED
BY INHALED POLLUTANTS USING MAGNETIC RESONANCE
IMAGING, MICROSCOPY, AND MODELING
PM 13
BASIC
Chairperson(s): Jack R. Harkema, Michigan State University, East
Lansing, MI and Richard Corley, Pacific Northwest National Laboratories,
Richland, WA.
Endorsed by:
Inhalation SS*
The goal of this course is to present state-of-the-art methods of assessing
injury and remodeling of the conducting airways caused by acute or
chronic exposures to airborne toxicants including environmental pollutants (e.g., particulate matter, ozone, cigarette smoke, fungal, and bacterial
toxins). The nature, severity, and distribution of airway lesions caused by
these inhaled toxicants are due to an integration of several factors including
the physicochemical characteristics of the inhaled toxicant (e.g., size of the
particles, reactivity of the gas), the exposure regimen (e.g., short-versus
long-term, continuous versus episodic), local intra-airway dosimetry (e.g.,
hot spots of deposition at airway bifurcations, slow clearance from sites
of overload), and cellular susceptibility (e.g., sensitive versus resistant
epithelial cell types). Toxicant-induced alterations to the airway structure
range from oncotic or apoptotic cell death of epithelial cells lining the
luminal surface with concurrent acute inflammation to marked remodeling
of the airway wall due to intramural fibrosis, epithelial hyperplasia/metaplasia, and chronic active inflammation. The strengths and limitations of a
variety of state-of-the-art imaging techniques for visualizing macroscopic
changes to the respiratory tract, including magnetic resonance imaging
and computed tomography, will be presented along with those of more
routine methods of light, electron, and confocal microscopy for assessing
tissue and cellular pathology caused by inhaled pollutants. The fundamental principles of airway stereology will also be presented and how these
mathematically proven morphometric techniques may be used to quantify, without bias, changes to these tubular structures in order to estimate
severity of complex lesions. Finally, presenters will describe the development and implementation of computational models of geometrically correct
upper and lower airways used to define, site-specific, dose-response relationships along the respiratory tract of laboratory animals and to estimate
the risk of air pollutant exposures to human health.
•
An Overview of Airway Injury and Remodeling Caused by
Inhaled Toxicants: From the Nose-to-the-Lung and from Gases to
Particles, Jack R. Harkema, Michigan State University, East Lansing,
MI.
•
State-of-the-Art Techniques for Imaging the Upper and Lower
Respiratory Tract: Identifying Macroscopic to Microscopic
Airway Alterations Caused by Airborne Toxicants, Charles
Plopper, University of California-Davis, Davis, CA.
•
Sampling, Stereology, and Statistics: Quantifying Changes Along
Tubular Structures and Without Bias, Dallas Hyde, University of
California–Davis, Davis, CA.
•
Using Computer-Assisted Airway Reconstruction to Define DoseResponse Relationships, Julia Kimbell, CIIT Centers for Health
Research, Research Triangle Park, NC.
55
CE
45th Annual
Meeting & ToxExpo
45th Annual
Meeting & ToxExpo
CE
Notes
56
45th Annual
Meeting & ToxExpo
Program Description
All Scientific Sessions and Special Events will be held in the San Diego
Convention Center unless otherwise noted.
Friday
HESI/SETAC IN VITRO ADME BIOACCUMULATION
WORKSHOP
Details for this workshop can be found under the Friday, March 3 listing of
this event.
HESI/SETAC IN VITRO ADME BIOACCUMULATION
WORKSHOP
Saturday, March 4
2:00 PM to 5:00 PM
Room 14B
The ILSI Health and Environmental Sciences Institute’s (HESI) Development of Methods for a Tiered Approach to Assess Bioaccumulation of
Chemicals Subcommittee and the Society of Environmental Toxicology
and Chemistry (SETAC) are jointly hosting a workshop March 3–4, 2006
to explore the range of in vitro techniques that may be applied to evaluate
the bioaccumulation potential of chemicals.
COMMITTEE CHAIR ORIENTATION
If you will be a Committee Chairperson in 2006–2007, please make plans
to attend the Committee Chairperson Meeting scheduled for 2:00 PM–
5:00 PM, Saturday, March, 4. With new committee assignments taking
effect on May 1, 2006, the meeting is intended to provide new (and current,
if desired) chairpersons with a basic tutorial on the SOT structure, operation, and strategic direction. For additional information, please contact
SOT Headquarters.
HESI is a global branch of the International Life Sciences Institute, a
public, non-profit scientific foundation with branches throughout the
world. HESI provides an international forum to advance the understanding
and application of scientific issues related to human health, toxicology,
risk assessment and the environment. HESI is widely recognized among
scientists from government, industry and academia as an objective, sciencebased organization within which important issues of mutual concern can be
discussed and resolved in the interest of improving public health.
Saturday, March 4
5:30 PM to 9:00 PM
Room 16A
The need for this workshop has come about as a result of growing concerns
regarding the persistence, bioaccumulation, and toxicity of substances
(PBTs) released into the environment. New laws resulting from enactment
of the United Nations Stockholm Convention (Persistent Organic Pollutants
(POPs) Protocol) in May 2004 have led to significant new activity in the
assessment of PBTs. To address the scientific challenges associated with
developing bioaccumulation assessments for the many chemicals that need
to be assessed in the coming years, there is a need to develop efficient,
scientifically-defensible alternatives to existing methods. Domestic and
international reporting requirements are facilitating the development of
collaborative arrangements among industry, government, and academic
scientists to identify additional methods for assessing thousands of chemicals.
UNDERGRADUATE EDUCATION PROGRAM
Chairperson(s): Peter Thomas, CDI Chair, Covance Laboratories,
Madison, WI and Alice Villalobos, University of Rochester, Rochester, NY.
Sponsored by:
Committee for Diversity Initiatives
Event for undergraduate students and advisors receiving MARC travel
funding, and the SOT program volunteers.
During the workshop, recommendations will be developed for using in
vitro techniques for estimating bioaccumulation. In addition, the workshop
will seek to identify a path forward for achieving widespread acceptance of
these techniques. Finally, a strategy will be developed for validating these
techniques. The workshop proceedings will be submitted for publication in
the peer-reviewed literature.
The workshop will be held March 3–4, 2006 in the Columbia Room at the
San Diego Marriott Hotel and Marina. Space for the workshop is limited,
and participants will be accommodated on a first-come basis. To register
for the workshop, contact Mr. Eric Moore, of HESI, at (202) 659–3306 or
[email protected]. Registration information can also be found on the HESI
website at www.hesiglobal.org.
57
5:30 PM–6:00 PM
Orientation for SOT Hosts, Peer Mentors, and
Advisors (Room 19)
6:15 PM–7:00 PM
Opening Event
7:15 PM–7:45 PM
Dinner
7:45 PM–8:30 PM
Opening Lecture: “What is Toxicology?”
Craig Marcus, University of New Mexico,
Albuquerque, NM.
8:30 PM–9:00 PM
Dessert and Networking
FRI/SAT/SUN
Saturday, March 4
9:00 AM to 5:00 PM
Columbia Room
Friday, March 3
9:00 AM to 5:00 PM
Columbia Room
Saturday
45th Annual
Meeting & ToxExpo
Program Description (Continued)
Sunday
For Advisors:
FRI/SAT/SUN
12:30 PM–1:10 PM
Sunday, March 5
8:00 AM to 5:00 PM
Room 16A
Tips for Advising Prospective Graduate
Students, Richard Peterson, University of
Wisconsin, Madison, WI.
1:15 PM–1:55 PM
An Admissions Committee Perspective on
Student Diversity, Mary Ann Smith, University of
Texas School of Public Health, Houston, TX.
2:00 PM–2:40 PM
Madison, WI and Vicente Santa Cruz, Chevron-Phillips, The
Woodlands, TX.
Mentoring Diverse Undergraduates, Mary
Treinen-Moslen, University of Texas Medical
Branch, Galveston, TX.
All Participants:
Sponsored by:
3:00 PM–5:00 PM
The Sunday program is open to undergraduate students who registered for
this event on the Annual Meeting Registration Form, the undergraduate
students and advisors receiving MARC and Pfizer travel funding, and the
SOT program volunteers.
Sunday, March 5
10:00 AM to 5:00 PM
San Diego Natural History Museum
Balboa Park
8:00 AM–9:45 AM
Special Toxicology Lectures
8:15 AM–8:55 AM
Nanotechnology and Related Toxicology, Martin
Philbert, University of Michigan, Ann Arbor, MI.
8:55 AM–9:30 AM
A Toxicologist’s Role in Search for the Truth
about Iraq’s Weapons of Mass Destruction,
Robert Casillas, Battelle, Columbus, OH and
Medical Service Corp, U.S. Army Reserve.
9:30 AM–9:45 AM
Break
9:45 AM–10:15 AM
Contaminants, Endocrine Disruption, and
Wildlife: Lessons from the Swamp, Louis
Gillette, University of Florida, Gainesville, FL.
K–12 COMMITTEE OUTREACH EVENT: PARACELSUS
EXPLORES THE GENOME: TOXICOLOGY ADVANCES HEALTH
Chairpersons: Stacie Wild, Amgen, Thousand Oaks, CA and
Ken McMartin, Louisiana State University Health Science Center,
Shreveport, LA.
Sponsored by:
Committee for K–12 Education
The SOT Committee on K–12 Education has arranged for free admission to the San Diego Natural History Museum in Balboa Park!
Paracelsus will guide you, your children, teachers, and everyone through
the exhibit Genome: The Secret of How Life Works (http://genome.pfizer.
com/). Special activities and displays provided by SOT will correlate toxicology and genomics, explain how the discipline of toxicology is important
to our health, and encourage exploration of toxicology careers. The main
goal of the event is to enhance science education by stimulating children,
teachers, and parents to learn about science and multidisciplinary toxicology in a fun and informative museum exhibit.
10:15 AM–10:30 AM Undergraduates and Research: TBA
10:30–11:30 AM
Developmental Immunotoxicity of Dioxin: How
an Immunology Lab Ended up Studying
Reproductive Biology, B. Paige Lawrence,
Washington State University, Pullman, WA.
11:30 AM–12:30 PM Lunch
Directions for public transportation to Balboa Park are linked from the
event description on the SOT 2006 Annual Meeting Web site.
For Students:
12:30 PM–2:45 PM
Open Time with Academic Toxicology Program
Directors and Research Sponsors
Break out Sessions, 40-minute, concurrent
sessions, each repeated three times
Sunday, March 5
4:45 PM to 5:15 PM
Room 6C
A) What is Graduate School and What Can I
Expect?, Adrian Nanez, University of Louisville,
Louisville, KY and Jennifer Rayner, University of
North Carolina Chapel Hill, Chapel Hill, NC.
PERFOMANCE BY THE SAN DIEGO UNIVERSITY CHORAL
SCHOLARS
The San Diego Choral Scholars will perform prior to and immediately
after the 2006 Awards Ceremony. This world-traveling mixed ensemble is
composed of a dozen undergraduate singers from San Diego State University. All attendees are welcome.
B) How to Get into Graduate School: An
Academic Advisor’s Perspective, Heather Kleiner
and Tammy Dugas, Louisiana State University
Health Science Center, Shreveport, LA.
Sunday, March 5
5:15 PM to 6:30 PM
Room 6C
C) What Road Should I Take? Suggestions
for Discussion with Program Directors,
Internship Hosts, and Poster Presenters, Vicente
Santa Cruz, Chevron Phillips Chemical Company
LP, Woodlands, TX, and Antonio Baines,
University of North Carolina-Chapel Hill, Chapel
Hill, NC.
AWARDS CEREMONY
Join the Society in recognizing and honoring distinguished toxicologists as
they receive prestigious awards at the SOT Awards Ceremony.
58
45th Annual
Meeting & ToxExpo
Monday Morning
Sunday, March 5
6:30 PM to 7:30 PM
Sails Pavilion
Monday, March 6
8:00 AM to 2:00 PM
Room 16B
WELCOMING RECEPTION
Join us on as SOT kicks off its 45th Anniversary Celebration. This will be
a memorable evening of reminiscing with friends, good fun, and looking
to the future of SOT. Please join the Society in this inaugural event of the
Annual Meeting. Enjoy complimentary hors d’oeuvres; a cash bar will be
available.
Madison, WI and Javier Avalos, TopTox, Sacramento, CA.
Sponsored by:
Sunday, March 5
7:00 PM to 8:00 PM
Room 4
25-YEAR (OR MORE) MEMBER RECEPTION
Have you been a member of the Society of Toxicology for 25 years (or
more)? If so, please consider joining your colleagues in this 45th Celebration and recognition of the scientists who established the Society. Invitation
is required.
Sunday, March 5
7:30 PM to 8:30 PM
Room 33
8:00 AM–8:15 AM
Meeting of Students, Advisors, Peer Mentors,
and SOT Hosts
8:30 AM–9:15 AM
Plenary Lecture: Risk Communication, David
Ropeik, Harvard University, Boston, MA.
9:30 AM–11:15 AM
Special Poster Session for Visiting Students
11:30 PM–2:00 PM
Lunch, Career Panel, Discussion, and Closing
Session
Monday, March 6
8:30 AM to 9:15 AM
Room 6
STUDENT/POST-DOCTORAL FELLOW MIXER
The Student Advisory Committee hosts this opportunity for students
and post-doctoral fellows to gather, to meet new colleagues, and to
re-establish relationships in an informal atmosphere at the beginning of the
meeting. If you register for this event on the Annual Meeting Registration
Form, you will receive a ticket at no charge. Ticket and meeting badge are
required. Complimentary refreshments and a cash bar will be available.
PLENARY LECTURE: RISK COMMUNICATION—THE
PERCEPTION GAP, AN UNRECOGNIZED ASPECT OF RISK
Lecturer: David Ropeik, Harvard School of Public Health, Harvard
University, Boston, MA.
This talk will propose that the classic definition of Risk
= Hazard x Exposure is incomplete. A definition that
more fully reflects all aspects of risk is Hazard x Exposure x Perception. While it is often said that people are
wrong or irrational when their fears don’t match the
facts, their fears are real, and those fears often lead to
behaviors that compound the risk to themselves and
to society. The scientific understanding of the roots of
risk perception will be explained. More effective risk
communication, based on a respect for the realities of risk perception, will
be offered as a vital tool for closing ‘The Perception Gap’ and encouraging
people to make more informed and healthier choices.
Sunday, March 5
8:00 PM to 9:00 PM
Room 32
POST-DOCTORAL ASSEMBLY EVENT
Join your post-doc colleagues, after a visit to the Student/Post-doctoral
Fellow Mixer, at the Post-doctoral Assembly Event. The Post-doctoral
Assembly (PDA) is the formal group for these members. Take this opportunity to network with each other, discuss issues of importance to you, plan
activities, and get to know the members of the 2006–2007 PDA Board. The
featured speaker is Jose Manautou, 2006 Achievement Award recipient.
Light appetizers and cash bar will be available.
Monday, March 6
9:30 AM to 11:15 AM
Exhibit Hall
POSTER SESSION FOR VISITING STUDENTS
Chairperson(s): Javier Avalos, TopTox, Sacramento, CA.
Sponsored by:
This poster session is part of the Undergraduate Education Program. All
are welcome to view the specially selected presentations which provide an
overview of research in toxicology and demonstrate the diversity within the
discipline.
59
MONDAY
Event for undergraduate students and advisors receiving MARC travel
funding, and the SOT program volunteers.
45th Annual
Meeting & ToxExpo
Monday, March 6
9:30 AM to 12:00 NOON
Room 6E
Monday, March 6
9:30 AM to 12:00 NOON
Room 8
SYMPOSIUM SESSION: LIPIDOMICS OF CELL DEATH
SYMPOSIUM SESSION: REGULATION OF PHASE II
XENOBIOTIC METABOLIZING ENZYMES: IMPLICATIONS
FOR HEALTH AND DISEASE
Chairperson(s): Brian Cummings, University of Georgia, Athens, GA.
Endorsed by:
Chairperson(s): Melissa Runge-Morris, Wayne State University, Detroit,
MI.
MONDAY
Lipidomics, the study of the effect of lipids on cellular physiology and
death, is a new and rapidly emerging area of research with great promise in
molecular toxicology. Phospholipids make up cell and organelle membranes
and by their physical-chemical properties are integral to the maintenance of
cell homeostasis. In addition, these molecules are critical to cell signaling
pathways. Therefore, to toxicologists this often-overlooked cell component
plays interesting, and often pivotal, roles in toxicity and pathogenesis. For
example, studies on the roles of phospholipids during phospholipidosis,
apoptosis, phagocytosis, oxidative stress and mitochondrial dysfunction
all can yield new and vital information about the mechanisms of such
processes. In addition, a variety of advanced techniques for the assessment of phospholipids have increased our ability to perform lipidomics,
including flow cytometry, electrospray ionization-mass spectrometry and
high performance thin layer chromatography. Thus, lipidomics offers great
promise into identifying mechanisms of toxicant-induced cell death.
#12
9:30
LIPIDOMICS OF CELL DEATH. B. S.
Cummings1, D. K. Monteith2, V. E. Kagan3 and B.
Fadeel4. 1Pharmaceutical and Biomedical Sciences,
University of Georgia, Athens, GA, 2Eli Lilly
& Company, Greenfield, IN, 3Environmental &
Occupational Health, University of Pittsburgh,
Pittsburgh, PA and 4Environmental Medicine,
Karolinska Institute, Stockholm, Sweden.
Endorsed by:
Molecular Biology SS*
The tight regulation of phase II xenobiotic-metabolizing enzymes such as
the sulfotransferase (SULT), UDP-glucuronosyl transferase (UGT), Nacetyltransferases (NAT) and glutathione-S-transferases (GST) multigene
families, represents an essential component of detoxication. In human
populations, genetic polymorphisms determine the phenotype of NAT1
and NAT2 and together with tissue-specific gene expression, influence
cancer risk following exposure to aromatic and heterocyclic amines in
the environment. Emerging insights in the nuclear receptor field have
demonstrated that the hepatic SULT and UGT enzymes are not only coordinately regulated by members of the nuclear receptor superfamily, but also
modulate the levels of bio-active species that participate in nuclear receptor
signaling. Superimposed on these advances, the activation of the Keap1/
Nrf2 signaling pathway by oxidative stress mediators in the environment
has been recently shown to control the expression of key members of the
GST multigene family, as well as other xenobiotic-metabolizing enzyme
target genes. This symposium will provide an updated analysis on the
genomic and transcription factor controls that regulate SULT, UGT, NAT
and GST enzymes. Focused emphasis will be placed on the implications of
altered phase II enzyme gene expression for toxicity in humans.
#17
9:30
REGULATION OF PHASE II XENOBIOTIC
METABOLIZING ENZYMES: IMPLICATIONS
FOR HEALTH AND DISEASE. M. RungeMorris1, W. Xie2, T. Kensler3 and D. W. Hein4. 1Inst.
Envir.Health Sciences., Wayne State University,
Detroit, MI, 2Center for Pharmacogenetics and
Department of Pharmaceutical Sciences, University
of Pittsburgh, Pittsburgh, PA, 3Bloomberg School
of Public Health, Johns Hopkins University,
Baltimore, MD and 4Department of Pharmacology
& Toxicology, University of Louisville, Louisville,
KY.
#13
9:40
CHARACTERIZATION AND
CONSEQUENCES OF DRUG-INDUCED
PHOSPHOLIPIDOSIS. D. K. Monteith. Eli Lilly
#14
10:20
DETERMINATION OF PHOSPHOLIPID
PROFILES DURING CHEMOTHERAPEUTICINDUCED CELL DEATH. B. S. Cummings.
Pharmaceutical and Biomedical Sciences, University
of Georgia, Athens, GA.
#15
11:00
CARDIOLIPIN AND PHOSPHATIDYLSERINE/
OXIDATIVE SIGNALING IN APOPTOSIS AND
PHAGOCYTOSIS. V. E. Kagan. Environmental
& Occupational Health, University of Pittsburgh,
Pittsburgh, PA.
#18
9:35
ROLE OF TRANSCRIPTION FACTOR
NETWORKS IN THE CONTROL OF
SULFOTRANSFERASE GENE EXPRESSION.
M. Runge-Morris. Inst.Envir.Health Sciences.,
Wayne State University, Detroit, MI.
#16
11:40
ROLE OF LIPID RAFTS IN CELL DEATH:
FOCUS ON APOPTOSOME ACTIVATION AND
CHEMORESISTANCE. B. Fadeel. Environmental
Medicine, Karolinska Institute, Stockholm, Sweden.
Sponsor: B. Cummings.
#19
10:15
REGULATION OF UDP GLUCURONOSYL
TRANSFERASES BY THE ORPHAN
NUCLEAR RECEPTOR SUPERFAMILY. W.
Xie1. 1Center for Pharmacogenetics, University
of Pittsburgh, Pittsburgh, PA and 2Center for
Pharmacogenetics, University of Pittsburgh,
Pittsburgh, PA. Sponsor: M. Runge-Morris.
#20
11:00
REGULATION OF PHASE 2 ENZYMES
THROUGH THE KEAP1-NRF2 SIGNALING
PATHWAY. T. W. Kensler. Environmental Health
Sciences, Johns Hopkins University, Baltimore, MD.
60
45th Annual
Meeting & ToxExpo
11:45
REGULATION OF THE HUMAN ARYLAMINE
N-ACETYLTRANSFERASES: IMPLICATIONS
FOR CANCER SUSCEPTIBILITY. D. W. Hein,
A. Husain, J. States and D. F. Barker. Pharmacology
and Toxicology, University of Louisville, Louisville,
KY.
#26
WORKSHOP SESSION: SCREENING METHODS FOR
ASSESSING SKIN TOXICITY OF NANOMATERIALS
SYMPOSIUM SESSION: RISK ASSESSMENT IMPLICATIONS
OF DIRECT NOSE-TO-BRAIN TRANSPORT OF INHALED
XENOBIOTICS
Chairperson(s): Mary Jane Cunningham, Houston Advanced Research
Center, The Woodlands, TX and Nancy Monteiro-Riviere, North Carolina
State University, Raleigh, NC.
Chairperson(s): David C. Dorman, CIIT Centers for Health Research,
Research Triangle Park, NC and Jack R. Harkema, Michigan State
University, East Lansing, MI.
Endorsed by:
Dermal Toxicology SS*
In Vitro SS
Endorsed by:
Inhalation SS
Metals SS
Neurotoxicology SS
Toxicologic and Exploratory Pathology SS*
Nanoscale materials (whether engineered or anthropogenic) are structures
with characteristic dimensions between 1 and 100nm and are present at
ever increasing concentrations in the environment. Engineered nanomaterials include the prototype C60 molecules, otherwise known as fullerenes
or “Bucky balls”, nanowires, nanofibers, nanoscissors, and nanotubes. The
manufacture of these nanomaterials is scaling up to commercial levels.
Their smaller size attributes additional physical properties, like conductivity and reactivity, which allows them to be used in telecommunications,
alternative energy sources, and medical applications. These engineered
materials vary in their structures and physicochemical compositions.
Currently, efforts are being made to standardize the manufacturing practices, analytical and detection methods and nomenclature. However, little is
known about their toxicity and recent reports are conflicting. Dermal, inhalation and oral exposure are all major probable routes of exposure. Since
the skin is the largest organ of the body, it may be the utmost concern in
terms of human health. The presentations in this symposium will address
the background of these nanomaterials and will focus on new screening
methodologies for assessing their cytotoxicity utilizing several types of
skin model systems. Methodologies will include assays for skin viability,
absorption, transport and gene expression and protein expression profiling.
These presentations will provide a base line for interpretation of the toxicological implications for occupational or potential environmental exposure
that could possibly be used in risk assessment.
The olfactory system is unique in that it forms a direct interface between
the air and the central nervous system (CNS). There is growing evidence
that metals and other xenobiotics deposited within the nose can be absorbed
at this site and then undergo transport along either the olfactory or trigeminal nerve, thus bypassing the blood-brain-barrier. One metal of special
concern to be discussed in this symposium is manganese, a neurotoxic
metal shown to be able to cross synapses in the olfactory bulb and migrate
via secondary olfactory neurons to more distant nuclei of the brain. In
some cases, direct olfactory transport is a major pathway by which an
inhaled metal reaches the CNS. This symposium will present new discoveries concerning direct nose-to-brain transport of metals in the olfactory
pathway. This symposium will also discuss likely mechanisms by which
transport occurs and inter-species differences in nasal anatomy that may
play a role in metal olfactory uptake and transport.
#23
9:30
9:50
RISK ASSESSMENT IMPLICATIONS OF
DIRECT NOSE-TO-BRAIN TRANSPORT OF
INHALED XENOBIOTICS. J. Harkema2, D.
C. Dorman1, G. Oberdorster3 and M. Andersen1.
1
CIIT Centers for Health Research, Research
Triangle Park, NC, NC, 2Department of Food Safety
and Toxicology, Michigan State University, East
Lansing, MI and 3Department of Environmental
Medicine, Rochester University, Rochester, NY.
COMPARATIVE NASAL STRUCTURE,
FUNCTION AND TOXICOLOGY:
IMPLICATIONS FOR THE RISK OF DIRECT
TRANSPORT OF INHALED XENOBIOTICS
TO THE BRAIN. J. R. Harkema. Pathobiology,
Michigan State University, East Lansing, MI.
#24
10:30
AN OVERVIEW OF NOSE-TO-BRAIN
TRANSPORT OF INHALED METALS. D.
C. Dorman. CIIT Centers for Health Research,
#25
11:10
NEURONAL TRANSLOCATION OF INHALED
NANO-SIZED PARTICLES: CAUSE FOR
CONCERN? G. Oberdorster. Environmental
Medicine, University of Rochester, Rochester, NY.
RISK ASSESSMENT ISSUES RELATED TO
OLFACTORY TRANSPORT OF INHALED
MATERIALS. M. E. Andersen. Computational
Biology, CIIT-Centers for Health Research, Research
Triangle Park, NC.
Monday, March 6
9:30 AM to 12:00 NOON
Room 5A
Monday, March 6
9:30 AM to 12:00 NOON
Room 5B
#22
11:50
61
#27
9:30
SCREENING METHODS FOR ASSESSING
SKIN TOXICITY OF NANOMATERIALS. N.
Monteiro-Riviere2 and M. Cunningham1. 1Houston
Advanced Research Center, The Woodlands, TX and
2
North Carolina State University, Raleigh, NC.
#28
9:35
ASSESSING NANOMATERIAL
INTERACTIONS IN SKIN. N. A. MonteiroRiviere. Center for Chemical Toxicology Research
and Pharmacokinetics, North Carolina State
University, Raleigh, NC.
#29
10:10
GEL-BASED PROTEOMIC SCREENING
OF NANOTUBE TOXICITY IN HUMAN
KERATINOCYTES. F. Witzmann1 and N.
Monteiro-Riviere2. 1Cellular & Integrative
Physiology, Indiana University School of Medicine,
Indianapolis, IN and 2Center for Chemical
Toxicology Research and Pharmacokinetics, College
of Veterinary Medicine, North Carolina State
MONDAY
#21
45th Annual
Meeting & ToxExpo
#30
10:45
GENE EXPRESSION PROFILING AND A
SYSTEMS BIOLOGY APPROACH TO THE
SCREENING OF NANOSCALE MATERIALS.
M. Cunningham. Houston Advanced Research
Center, The Woodlands, TX.
#31
11:20
ASSESSING DERMAL PENETRATION
OF NANOMATERIALS BY LIGHT AND
ELECTRON MICROSCOPY. S. M. Roberts.
Ctr. Environment Human Toxicology, Univeristy of
Florida, Gainesville, FL.
Monday, March 6
9:30 AM to 12:00 NOON
Room 2
#35
10:40
ADVANCEMENTS IN MODELING THE
RESPIRATORY SYSTEM. R. A. Corley1, K. R.
Minard1, D. R. Einstein1, R. E. Jacob1, S. Kabilan1,
L. L. Trease1, E. A. Hoffman2, E. Postlethwait3,
C. Plopper4, J. S. Kimbell5, J. R. Harkema6, M.
Hlastala7 and C. Timchalk1. 1Pacific Northwest
National Laboratory, Richland, WA, 2University
of Iowa, Iowa City, IA, 3University of Alabama
at Birmingham, Birmingham, AL, 4University
of California at Davis, Davis, CA, 5CIIT Centers
for Health Research, Research Triangle Park,
NC, 6Michigan State University, Lansing, MI and
7
University of Washington, Seattle, WA.
#36
11:15
COUPLING THE QCP INTEGRATIVE
HUMAN PHYSIOLOGY MODEL AND THE
TOLUENE PBPK MODEL TO SIMULATE
COMPLEX EXPOSURE SCENARIOS IN
HUMANS. T. Coleman2 and V. Benignus1. 1U.S.
EPA, Research Triangle Park, NC and 2Biological
Simulators, Inc., Jackson, MS. Sponsor: R.
DeWoskin.
WORKSHOP SESSION: TOWARDS THE VIRTUAL HUMAN:
ADDING MORE PHYSIOLOGICAL DETAIL TO BIOLOGICALLYBASED MODELS
Chairperson(s): Robert DeWoskin, U.S. EPA, Research Triangle Park, NC
and Torka Poet, Pacific Northwest National Laboratory, Richland, WA.
MONDAY
Endorsed by:
Biological Modeling SS*
Mechanisms SS
Risk Assessment SS
Monday, March 6
9:30 AM to 12:00 NOON
Room 15A
Biologically based models have proven applications in risk assessment,
drug development, and health care primarily based upon their ability to
predict outcomes and extend the usefulness of limited data sets. Biological
models also help integrate diverse sets of data from in vitro and in vivo
studies (and the many “omics” technologies) into a coherent theoretical
framework of a chemical’s mode of action. The most common biological
models currently used in risk assessments are physiologically based pharmacokinetic (PBPK) models, which simulate the pharmacokinetics of a
toxin, generally at the whole body and organ level. A natural outcome of
the increased use of biological models in risk assessment is an interest in
ever increasing levels of physiological detail, with the ultimate goal being
a highly predictive whole body or virtual human model. Progress has been
slow; however, in part because of a lack of interaction between the physiology modeling community with its focus on medical applications and the
PBPK modeling community with its focus on risk assessment. This workshop begins to bridge some of this gap by presenting an overview of the
state of physiology modeling, some examples of systems level physiology
models, a case study of a hybrid physiology/PBPK model with improved
predictive capability, and a discussion of the challenges to using existing
physiology models in risk assessment.
PLATFORM SESSION: ALTERNATIVE MODELS FOR
ASSESSMENT OF TOXICITY
#32
9:30
Chairperson(s): John Schlager, U.S. Air Force, Wright Patterson Air Force
Base, OH and Brinda Mahadevan, Oregon State University, Corvallis, OR.
TOWARDS THE VIRTUAL HUMAN: ADDING
MORE PHYSIOLOGICAL DETAIL TO
BIOLOGICALLY BASED MODELS USED
IN RISK ASSESSMENT. T. S. Poet2 and R. S.
DeWoskin1. 1U.S. EPA, Research Triangle Park,
NC and 2Pacific Northwest National Laboratory,
Richland, WA.
#33
9:35
CURRENT STATUS AND CHALLENGES IN
THE USE OF PHYSIOLOGY MODELS IN
RISK ASSESSMENT. R. S. DeWoskin1 and T. S.
Poet2. 1U.S. EPA, Research Triangle Park, NC and
2
PNNL, Richland, WA.
#34
10:05
THE PHYSIOME IN PHARMACOKINETICS,
PHARMACODYNAMICS AND TOXICOLOGY.
J. B. Bassingthwaighte, A. Matuszkiewicz, M.
Krueger, J. S. Park, G. M. Raymond, E. Butterworth,
M. Neal and M. Hlastala. University of Washington,
Seattle, WA. Sponsor: R. DeWoskin.
62
#37
9:30
EFFECT OF SILVER NANOPARTICLES ON
SRC ACTIVITY IN MALE GERM-LINE STEM
CELLS. L. K. Braydich-Stolle1, S. Hussain2, J. J.
Schlager2 and M. Hofmann1. 1Biology, University
of Dayton, Dayton, OH and 2Air Force Research
Laboratory, Wright Patterson Air Force Base,
Dayton, OH.
#38
9:46
BULKY DNA ADDUCT REPAIR ENZYME XPA
IN EARLY DEVELOPMENT OF ZEBRAFISH.
B. Mahadevan, E. Brooks, J. Atkin, M. J. Reimers,
R. L. Tanguay and W. M. Baird. Environmental and
Molecular Toxicology, Oregon State University,
Corvallis, OR.
#39
10:02
ASSESSMENT OF DEVELOPMENTAL
NEUROTOXICITY IN ZEBRAFISH AFTER
EXPOSURE TO ENVIRONMENTAL TOXINS.
C. Willett, N. Roy, Y. Lin, C. Ton, C. Parng and
P. McGrath. Phylonix Pharmaceuticals, Inc.,
Cambridge, MA. Sponsor: L. Costa.
#40
10:18
WORMTOX: TOXICOLOGICAL SCREENING
TOOLS USING THE NEMATODE
Caenorhabditis elegans. W. Boyd1, S. McBride2, J.
Rice1, D. Snyder1 and J. Freedman1, 2. 1Laboratory of
Molecular Toxicology, NIEHS, Research Triangle
Park, NC and 2NSOEES, Duke University, Durham,
NC.
#41
10:34
A HIGH SPECIFICITY, HIGH THROUGHPUT
IN VITRO GENOTOXICITY SCREENING
ASSAY IN HUMAN CELLS. R. Walmsley1 and P.
W. Hastwell2. 1Gentronix Ltd., Manchester, United
Kingdom and 2GSK, Ware, United Kingdom.
Sponsor: S. Dean.
45th Annual
Meeting & ToxExpo
#42
10:50
IN VITRO ANALYSIS OF THE SENSITIZING
PROPERTIES OF OXIDATION
AND METABOLIC PRODUCTS OF
P-PHENYLENEDIAMINE AND PTOLUYLENEDIAMINE. P. Aeby1, O. Goettel1,
H. Beck1, L. Chassot1, F. Protopapa1, S. Rossier1
and C. Goebel2. 1Toxicology, Cosmital SA, Marly,
Switzerland and 2Product Safety, Wella AG,
Darmstadt, Germany. Sponsor: F. Gerberick.
#43
11:06
IN VITRO IDENTIFICATION OF CONTACT
ALLERGENS TEST BASED ON THE
ACTIVATION OF U937 CELLS. F. Python1, 3,
C. Goebel2 and P. Aeby1. 1Toxicology, Cosmital
SA, Marly, Switzerland, 2Product Safety, Wella
AG, Darmstadt, Germany and 3Supported by
The European Cosmetic Toiletry and Perfumery
Association, COLIPA, Brussels, Belgium. Sponsor:
F. Gerberick.
#44
#45
11:22
11:38
XENOBIOTIC METABOLIZING
ENZYME (XME) EXPRESSION IN THE
EPIDERM IN VITRO HUMAN SKIN
EQUIVALENT: UTILITY FOR ASSESSING
DERMAL BIOTRANSFORMATION OF
PHARMACEUTICALS, COSMETICS AND
ENVIRONMENTAL CHEMICALS. G. Stolper1,
J. Bolmarcich1, M. Aardema2, T. Hu2, R. D. Curren3,
M. Klausner1, J. Kubilus1 and P. J. Hayden1. 1MatTek
Corp., Ashland, MA, 2Procter & Gamble Company,
Cincinnati, OH and 3The Institute for In Vitro
Sciences, Gaithersburg, MD.
9:55
#49
10:45
A FUNCTIONAL OBSERVATIONAL
BATTERY (FOB) COMPARISON STUDY OF
12 PYRETHROIDS IN RATS. L. P. Sheets1, D.
E. Sargent1, M. Nemec2, C. Breckenridge1, M. R.
Creek1, L. S. Mullin1, J. Sharp1 and M. L. Weiner1.
1
Toxicology Committee, Pyrethroid Working Group,
Research Triangle Park, NC and 2WIL Research
Laboratories, LLC, Ashland, OH.
#50
11:10
PRINCIPAL COMPONENTS AND FACTOR
ANALYSIS OF THE FUNCTIONAL
OBSERVATIONAL BATTERY OF 12
PYRETHRIODS. C. Breckenridge1, L. Holden2, D.
E. Sargent1, L. Sheets1, M. R. Creek1, L. S. Mullin1,
J. Sharp1 and M. L. Weiner1. 1Toxicology Committee,
Pyrethroid Working Group, Research Triangle Park,
NC and 2Sielkin Associates, College Station, TX.
#51
11:35
NEIGHBORHOOD ENVIRONMENTAL
STRESS MODIFIES THE EFFECT OF
LEAD ON COGNITION: THE BALTIMORE
MEMORY STUDY. T. A. Glass1, K. BandeenRoche3, M. McAtee1 and B. S. Schwartz2.
1
Epidemiology, Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD, 2Environmental
Health Sciences, Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD and 3Biostatistics,
Johns Hopkins Bloomberg School of Public Health,
Baltimore, MD.
PLATFORM SESSION: GENE EXPRESSION CHANGES IN
CARCINOGENESIS
Chairperson(s): Stephanie Padilla, U.S. EPA, Research Triangle Park, NC
and Larry Sheets, Bayer CropScience, Stilwell, KS.
#47
COST-EFFECTIVE OPTIMIZATION OF
A NEUROPATHOLOGY PROTOCOL FOR
USE IN REGULATORY DEVELOPMENTAL
NEUROTOXICITY STUDIES. D. De Groot1,
M. Otto1, M. Moerkens1, M. Waanders1, L. vd
Horst1, S. Hartgring1, M. Pelgrim1, D. Waalkens1,
J. Lammers1, M. Bos1, W. Kaufmann2, J.
O’Callaghan3, H. Gundersen4, M. Lundberg4, S.
Sorensen5 and B. Pakkenberg5. 1TNO Quality of
Life, Zeist, Netherlands, 2NIOSH, Morgantown,
WV, 3BASF, Ludwigshafen, Germany, 4University,
Aarhus, Denmark and 5Res.Lab.Sterol.&Neurosc.,
Copenhagen, Denmark. Sponsor: V. Feron.
Monday, March 6
9:30 AM to 12:00 NOON
Room 1A
PLATFORM SESSION: FRONTIERS OF NEUROTOXICOLOGY:
EXTRAPOLATION AND HUMAN HEALTH
9:30
10:20
COMPARATIVE EVALUATION OF
BENZALKONIUM CHLORIDE ON IN
VITRO RABBIT AND HUMAN CORNEAS.
D. Ghate1, G. Holley1, D. Bagley2, M. Blazka2
and H. F. Edelhauser1. 1Ophthalmology, Emory
University Eye Center, Atlanta, GA and 2Research
and Development, Colgate-Palmolive company,
Piscataway, NJ.
Monday, March 6
9:30 AM to 12:00 NOON
Room 7B
#46
#48
Chairperson(s): Jay Goodman, Michigan State University, East Lansing,
MI and Robert Smart, North Carolina State University, Raleigh, NC.
A DOSE-RESPONSE STUDY OF THE
TOXICITY OF A MIXTURE OF 7 N-METHYL
CARBAMATE PESTICIDES IN ADULT, MALE
RATS. S. Padilla1, W. Setzer2, R. S. Marshall1, D. L.
Hunter1, P. Phillips1, K. McDaniel1, V. C. Moser1 and
A. Lowit3. 1NTD, U.S. EPA, Research Triangle Park,
NC, 2NCCT, U.S. EPA, Research Triangle Park, NC
and 3OPP, U.S. EPA, Washington, DC.
#52
EXPLORING THE USE OF
CAENORHABDITIS ELEGANS AS A MODEL
FOR MAMMALIAN NEUROTOXICITY
USING CARBAMATE PESTICIDES. P. C.
Melstrom and P. L. Williams. Environmental Health
Science, University of Georgia - Athens, Athens,
GA.
63
9:30
ALTERED METHYLATION IN GENESPECIFIC AND GC-RICH REGIONS IS
PROGRESSIVE AND NON-RANDOM DURING
PROMOTION OF SKIN TUMORIGENESIS.
A. N. Bachman1, G. M. Curtin2, D. J. Doolittle2 and
J. I. Goodman1. 1Pharmacology and Toxicology,
Michigan State University, East Lansing, MI and
2
Research and Development, R. J. Reynolds Tobacco
Company, Winston-Salem, NC.
MONDAY
45th Annual
Meeting & ToxExpo
#53
9:48
KIDNEY TOXICOGENOMICS OF CHRONIC
POTASSIUM BROMATE EXPOSURE IN F344
MALE RAT. D. Geter1, W. Ward1, G. Knapp1, A.
DeAngelo1, J. Rubis2, R. Owen1 and D. Delker1. 1U.S.
Environmental Protection Agency, Research Triangle
Park, NC and 2CIIT Centers for Health Research,
#54
10:06
GENE EXPRESSION PROFILING OF
MOUSE SKIN AND PAPILLOMAS
FOLLOWING CHRONIC EXPOSURE TO
MONOMETHYLARSONOUS ACID IN K6/
ODC TRANSGENIC MICE. D. Delker1, M.
Ouyang2, W. Welsh2, B. Roop1, D. Geter1, Y. Chen3,
T. O’Brien3 and K. Kitchin1. 1U.S. EPA, Durham,
NC, 2UMDNJ, Piscataway, NJ and 3ODC Mouse
Group, Drexel Hill, PA.
#55
10:24
MONDAY
10:42
COMPARISON OF GENE EXPRESSION
CHANGES IN PANCREAS OF RATS
FED DIETS CONTAINING WYETH 14,
643, DIETHYLHEXYLPHTHALATE OR
AMMONIUM PERFLUOROOCTANOATE
(APFO). C. Elcombe and S. Plummer. CXR
Biosciences Ltd., Dundee, United Kingdom.
#57
11:00
GENE EXPRESSION PROFILING SPECIFIC
TO THE TUMOR PROMOTION PROCESS
OF RAT THYROID CARCINOGENESIS
INDUCED BY SULFADIMETHOXINE OR
KOJIC ACID. M. Shibutani1, K. Inoue1, G. Woo1,
K. Igarashi2, J. Kanno2 and M. Hirose1. 1Division
Pathol., National Institute Health Sciences., Tokyo,
Japan and 2Division Mol. Toxicol., National Institute
Health Sciences., Tokyo, Japan. Sponsor: M. Ema.
11:18
11:36
THE INDUCTION OF CCAAT/ ENHANCER
BINDING PROTEIN ALPHA IN HUMAN
EPIDERMIS FOLLOWING UVB EXPOSURE
AND THE EFFECT OF ARSENIC ON THIS
RESPONSE. E. A. Thompson1, D. M. Owens2
and R. C. Smart1. 1Environmental and Molecular
Toxicology, North Carolina State University,
Raleigh, NC and 2Departments of Dermatology
and Pathology, Columbia University, College of
Physicians and Surgeons, New York.
Monday, March 6
9:30 AM to 12:00 NOON
Room 7A
PLATFORM SESSION: MODULATION OF CARCINOGENESIS
BY NATURALLY OCCURING POLYPHENOLIC COMPOUNDS
CORRELATION BETWEEN GENE
EXPRESSION IN HUMAN CELLS AND
TUMOR INITIATION IN SENCAR MICE
ON EXPOSURE TO A STANDARDIZED
COMPLEX MIXTURE DERIVED FROM
DIESEL EXHAUST. L. A. Courter1, B.
Mahadevan1, C. Keshava2, T. Musafia-Jeknic1,
K. Fischer3, E. Brooks1, R. Bildfell3, A. Weston2
and W. M. Baird1. 1Environmental and Molecular
Toxicology, Oregon State University, Corvallis,
OR, 2National Institute for Occupational Safety
and Health, CDC, Morgantown, WV and 3School
of Veterinary Medicine, Oregon State University,
Corvallis, OR.
#56
#58
#59
Chairperson(s): James Trosko, Michigan State University, East Lansing,
MI.
SEQUENTIAL PHOSPHORYLATION BY
PROTEIN KINASE CK2 REGULATES
NRF2 ACTIVATION AND DEGRADATION:
POTENTIAL ROLE IN ARSENIC-INDUCED
SKIN CARCINOGENESIS. J. Pi1, 2, B. A.
Diwan3, W. Qu1, J. Liu1, Y. Bai2, W. Fahl4, H.
Yamauchi5, S. Collins2 and M. P. Waalkes1. 1LCC,
NCI at NIEHS, Research Triangle Park, NC, 2CIIT
Centers for Health Research, Research Triangle
Park, NC, 3SAIC, NCI, Frederick, MD, 4University
of Wisconsin, Madison, WI and 5St. Marianna
University School of Medicine, Kawasaki, Japan.
64
#60
9:30
THE COMBINATION OF EGCG AND
TAMOXIFEN SUPPRESSES THE GROWTH
OF ERα- BREAST TUMORS IN MICE: ROLE
OF TAMOXIFEN-MEDIATED CHANGES IN
THE METABOLISM OF EGCG. E. C. Stuart1,
M. J. Scandlyn1, A. R. Menzies1, M. J. Le Nedelec1,
L. Larsen2, N. B. Perry2 and R. J. Rosengren1.
1
Pharmacology & Toxicology, Univeristy of Otago,
Dunedin, New Zealand and 2New Zealand Institute
for Crop and Food Reserach Ltd., Dunedin, New
Zealand.
#61
9:48
AUGMENTATION OF DIFFERENTIATION
AND GAP JUNCTION FUNCTION
BY KAEMPFEROL IN PARTIALLY
DIFFERENTIATED COLON CANCER CELLS.
Y. Nakamura1, C. Chang2, T. Mori3, K. Sato1, K.
Ohtsuki1, B. L. Upham2 and J. E. Trosko2. 1Food
Science, Kyoto Pref. University Kyoto, Japan,
2
Pediatrics and Human Development, Michigan
State University Lansing, MI and 3Radioisotope
Research Center, Nara Medical University Nara,
Japan.
#62
10:06
POSSIBLE MECHANISM OF
CHEMOPROTECTION OF CAFFEIC ACID
PHENETYL ESTER ON INICIATION IN
A HEPATOCARCINOGENESIS ASSAY. O.
Beltran-Ramirez2, A. Sierra-Santoyo1, J. HernandezMartinez3 and S. Villa-Trevino2. 1Toxicology,
CINVESTAV-IPN, Mexico City, D.F., Mexico, 2Cell
Biology Department, CINVESTAV-IPN, Mexico
City, D.F., Mexico and 3Direccion de Tecnologia
de Alimentos de Origen Animal, CIAD, AC,
Hermosillo, Sonora, Mexico.
#63
10:24
2D GEL PROTEOMICS IN MECHANISTIC
ANALYSIS OF CHEMOPREVENTATIVE
FLAVONOIDS AND BENZO(A)PYRENE IN
PROSTATE CANCER CELL. A. M. Chaudhary1,
T. Pechan2 and K. L. Willett1. 1Pharmacology,
University of Mississippi, University, MS and
2
LSBI, Mississippi State University, Mississippi
State, MS.
45th Annual
Meeting & ToxExpo
#64
10:42
BIFUNCTIONAL EFFECT OF
RESVERATROL ON THE EXPRESSION OF
ERBB2 IN HUMAN BREAST CANCER CELL.
J. Yang and K. Kang. College of Pharmacy, Chosun
University, Gwangju, South Korea. Sponsor: H.
Jeong.
#65
11:00
MECHANISM OF TEA CATECHIN AND
CAFFEINE IN INHIBITION OF LUNG
TUMOR PROGRESSION INDUCED BY
4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)1-BUTANONE (NNK) IN A/J MOUSE. G. Lu and
C. S. Yang. Rutgers University, Piscataway, NJ.
#66
11:18
INHIBITION OF GAP JUNCTIONAL
INTERCELLULAR COMMUNICATION
BY PHOSPHOLIPID METABOLITES
AND PROTECTION BY THE RED WINE
ANTIOXIDANT, RESVERATROL. B. L. Upham,
J. E. Trosko and L. Blaha. Pediatrics/Human
Development, Michigan State University, East
Lansing, MI.
#67
11:36
INDUCTION OF DIFFERENTIATION BY
KAEMPFEROL IN COLON CANCER CELLS
WITH DIFFERENT DIFFERENTIATION
PROFILES. Y. Nakayama1, Y. Nakamura1, K. Sato1,
C. Chang2, B. L. Upham2 and J. E. Trosko2. 1Food
Science, Kyoto Pref. University Kyoto, Japan and
2
Pediatrics and Human Development, Michigan
State University Lansing, MI.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
#69
PHYSIOLOGICALLY BASED
PHARMACOKINETIC/
PHARMACODYNAMIC (PBPK/PD)
SIMULATION OF LOW LEVEL GB
EXPOSURE ACROSS MULTIPLE SPECIES.
J. Gearhart1, 5, P. Robinson1, 5, E. Jakubowski2,
R. Mioduszewski2, S. Thomson2, R. Genovese3,
C. Willmore3, A. Saxena3 and G. Rockwood4.
1
Alion Science and Technology, Dayton, OH, 2US
Army ECBC, APG-EA, Aberdeen Proving Grd.,
MD, 3WRAIR, Silver Spring, MD, 4USAMRICD,
Aberdeen Proving Grd., MD and 5AFRL/HEPB,
Wright-Patterson AFB, OH.
#70
A COMPARISON OF THE CYCLOSARIN AND
SARIN FLUORIDE ION REGENERATION
RESULTS FROM MINIPIG BLOOD AND
TISSUE FOLLOWING WHOLE BODY VAPOR,
INTRAVENOUS, OR SUBCUTANEOUS
EXPOSURES. E. M. Jakubowski1, J. M. McGuire1,
R. A. Evans2, S. W. Hulet1, J. A. Renner2, A. L.
Totura2, T. T. Belski2, W. T. Muse1, D. B. Miller1, R.
J. Mioduszewski1 and S. A. Thomson1. 1Toxicology
Team, Edgewood Chemical Biological Center, APGEdgewood, MD and 2Geo-Centers, Edgewood, MD.
#71
A COMPARATIVE STUDY OF THE BINDING
CHARACTERISTICS OF SARIN IN BLOOD
ACROSS VARIOUS ANIMAL MODELS. J.
McGuire1, E. M. Jakubowski1, R. A. Evans2, R.
J. Mioduszewski1 and S. A. Thomson1. 1US Army
ECBC, Aberdeen Proving Ground, MD and 2GeoCenters, Inc., Aberdeen Proving Ground, MD.
#72
MEDIAN EFFECTIVE DOSAGES FOR
MIOSIS (ECT50) AND LETHALITY (LCT50)
IN GOTTINGEN MINIPIGS FOLLOWING
10, 60 AND 180-MINUTE WHOLE-BODY
EXPOSURES TO CYCLOSARIN (GF) VAPOR.
S. W. Hulet1, D. R. Sommerville1, R. B. Crosier1, P.
A. Dabisch1, C. L. Krauthauser2, J. A. Scotto1, D. B.
Miller2, W. T. Muse1, B. J. Benton1, J. R. Jarvis2, R. J.
Mioduszewski1 and S. A. Thomson1. 1Toxicology, US
Army -SBCCOM, Aberdeen Proving Grounds, MD
and 2Geo-Centers, Inc., Abingdon, MD.
#73
DIFFERENTIAL EFFECTS OF SARIN
VAPOR EXPOSURE ON THE OCULAR AND
CARDIOVASCULAR SYSTEMS. P. A. Dabisch1,
E. Davis1, M. Horsmon2, D. Miller2, J. Scotto1,
R. Mioduszewski1 and S. Thomson1. 1Toxicology,
U.S. Army Edgewood Chemical Biological Center,
Aberdeen Proving Ground, MD and 2Geo-Centers,
Inc., Gunpowder, MD.
#74
EFFECT OF PYRIDOSTIGMINE
PRETREATMENT ON SARIN VAPORINDUCED MIOSIS. M. Horsmon1, P. Dabisch2,
E. Davis2, R. Mioduszewski2 and S. Thomson2.
1
Geo-Centers, Gunpowder, MD and 2Toxicology,
Universtiy of.S Army Edgewood Chemical
Biological Center, Aberdeen Proving Ground, MD.
POSTER SESSION: CHEMICAL-BIOLOGICAL WEAPONS I
Chairperson(s): Jeff Gearhart, Alion Science and Technology, Dayton,
OH and Madhusoodana Nambiar, Walter Reed Army Institute of Research,
Silver Spring, MD.
Displayed: 9:30 AM–12:00 NOON
Attended: 9:30 AM–11:00 AM
#68
TOXICOKINETICS OF INHALED AND
PARENTERAL SARIN (GB) FOLLOWING
SINGLE AND MULTIPLE SUB-LETHAL
EXPOSURES IN THE GUINEA PIG (GP). C.
E. Whalley1, L. A. Lumley2, J. M. McGuire1, E.
M. Jakubowski1, D. B. Miller3, J. H. McDonough2,
R. J. Mioduszewski1, S. A. Thomson1 and T. A.
Shih2. 1ECBC, Aberdeen Proving Ground, MD,
2
USAMRICD, Aberdeen Proving Ground, MD and
3
Geo-Centers, Inc., Aberdeen Proving Ground, MD.
65
MONDAY
45th Annual
Meeting & ToxExpo
#75
#76
DEVELOPMENT OF AN HPLC-ESI-MS
METHOD FOR THE DETERMINATION
OF PYRIDOSTIGMINE IN RAT PLASMA.
E. Davis, P. Dabisch, R. Mioduszewski and S.
Thomson. Analytical Toxicology, U.S. Army
Edgewood Chemical Biological Center, Abderdeen
Proving Ground, MD.
MONDAY
EFFECTS OF WHOLE-BODY VX VAPOR
EXPOSURE ON LETHALITY IN RATS. B. J.
Benton, J. M. McGuire, D. R. Sommerville, P. A.
Dabisch, E. M. Jakubowski, R. J. Mioduszewski
and S. A. Thomson. Operational Toxicology, ECBC,
Aberdeen Proving Ground, MD.
#78
REDUCED BODY TEMPERATURE AND
IMPAIRED MOTOR COORDINATION
IN RATS EXPOSED TO ACUTE AND
REPEATED SUB-LETHAL DOSES OF VX. L.
A. Lumley, C. L. Robison, A. R. Kohli, A. Capili,
B. Somsamayvong and T. Shih. Pharmacology,
USAMRICD, Aberdeen Proving Ground, MD.
#79
TOXIC EFFECTS OF THE CHEMICAL
WARFARE NERVE AGENT VX ON
RESPIRATORY PHYSIOLOGY AND
FUNCTION IN GUINEA PIGS. P. E. Rezk1,
M. P. Nambiar1, 3, J. R. Graham1, R. K. Gordon1,
T. E. Moran2 and A. M. Sciuto2. 1Biochemical
Pharmacology, Walter Reed Army Institute of
Research, Silver Spring, MD, 2Medical/Analytical
Toxicology, USAMRICD, Edgewood, MD and
3
Medicine, USUHS, Bethesda, MD.
#81
POSTER SESSION: PERSISTENT ORGANIC POLLUTANTS
Chairperson(s): Nigel Walker, NIEHS, Research Triangle Park, NC and
Arnold Schecter, University of Texas School of Public Health, Dallas, TX.
DIFFERENTIAL EFFECTS OF SARIN
GAS EXPOSURE REGIMEN ON AIRWAY
REACTIVITY AND CYTOKINE EXPRESSION.
M. J. Campen, S. Razani-Boroujerdi, S. Lucas,
J. Pena-Philippides and M. Sopori. Lovelace
Respiratory Research Institute, Albuquerque, NM.
#77
#80
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
Attended: 10:30 AM–12:00 NOON
LOW-LEVEL INHALATION EXPOSURE TO
VX VAPOR INDUCES ALTERATIONS OF KEY
GENES AND PROTEINS IN THE BRAIN AND
BLOOD PLASMA OF RATS. J. W. Sekowski1, J.
Bucher1, M. Orehek1, M. Horsmon1, J. J. Valdes1,
C. Whalley1, B. Benton1, W. Muse1, D. Miller1,
C. L. Crouse1, K. Matson1, J. Scotto1, J. Forster1,
J. Manthei1, R. Way1, D. Burnett1, B. Gaviola1, R.
Mioduszewski1, S. Thomson1, S. Martino-Catt2,
K. Lee2, S. Cammer2, O. Crasta2, M. Nau3 and M.
Vahey3. 1Edgewood Chemical Biological Center,
U.S. Army, APG-EA, MD, 2Virginia Bioinformatics
Institute, Virginia Polytechnic Institute and
University, Blacksburg, VA and 3Gene Array Facility,
Walter Reed Army Institute of Research, Rockville,
MD.
CUTANEOUS EXPOSURE TO GD AND VX:
TIMING OF ANTIDOTES. E. D. Clarkson, S. M.
Schulz, R. F. Railer, S. A. Mendy, T. P. Logan and S.
I. Baskin. Medical Toxicology, U.S. Army Institute
for Chemical Defense, Aberdeen Proving Grounds,
MD.
66
#82
COMPARATIVE TOXICOGENOMIC
ANALYSIS OF THE HEPATOTOXIC EFFECTS
OF TCDD IN RATS AND MICE. A. S. Harney1,
D. R. Boverhof1, L. D. Burgoon1, S. S. Lundback1, D.
L. Mendrick2 and T. R. Zacharewski1. 1Department
of Biochemistry & Molecular Biology and
Center for Integrative Toxicology, Michigan State
University, East Lansing, MI and 2Gene Logic Inc.,
Gaithersburg, MD.
#83
STRAIN DIFFERENCE IN TCDD TOXICITIES
IN LONG-EVANS AND WISTAR HANNOVER
GALAS RATS. T. Kawakami3, 2, K. Shiizaki3, Y.
Murakami3, T. Takahara4, K. Takeda2, C. Tohyama1, 3
and S. Ohsako3, 1. 1Division of Environment Health,
The University of Tokyo, Graduate School of
Medicine, Tokyo, Japan, 2Facility of Pharmaceutical
Sciences., Tokyo University of Sciences., Tokyo,
Japan, 3Environment Health Sciences. Division,
National Institute for Environment Studies, Tsukuba,
Japan and 4Shin Nippon Biomedical Laboratory,
Kainan, Japan.
#84
EVALUATION OF VARIOUS HOUSEKEEPING
GENES FOR THEIR APPLICABILITY FOR
NORMALIZATION OF mRNA EXPRESSION
IN DIOXIN-TREATED RATS. M. Niittynen1,
2
, J. Linden3, P. C. Boutros4, I. D. Moffat4, A. B.
Okey4 and R. Pohjanvirta1, 3, 5. 1Department of
Environmental Health, National Public Health
Institute, Kuopio, Finland, 2Department of
Pharmacology and Toxicology, University of
Kuopio, Kuopio, Finland, 3Department of Food and
Environmental Hygiene, University of Helsinki,
Helsinki, Finland, 4Department of Pharmacology,
University of Toronto, Toronto, ON, Canada and
5
Department of Kuopio, National Veterinary and
Food Research Institute, Kuopio, Finland. Sponsor:
M. Viluksela.
#85
SUPPRESSION OF TCDD-INDUCED CYP1A1
EXPRESSION BY CAPSAICIN IN MOUSE
HEPATOMA HEPA-1C1C7 CELLS. H. Soo Jin1,
E. Han1, 2, J. Kim1, 2 and H. Jeong1, 2. 1Pharmacy,
Chosun University, Kwangju, South Korea and
2
Research Center for Proteineous Materials, Chosun
University, Kwangju, South Korea.
45th Annual
Meeting & ToxExpo
#86
2, 3, 7, 8-TETRACHLORODIBENZO-pDIOXIN INCREASES THE EXPRESSION
AND ACTIVATION OF MATRIX
METALLOPROTEINASE-2 IN HUMAN
FIBROSARCOMA HT1080 CELLS. J. H. Choi1,
2
, J. Y. Kim1, H. G. Kim1, 2, E. H. Han1, 2, Y. P.
Hwang1, 2, K. N. Oh1, 2 and H. Jeong1, 2. 1Pharmacy,
2
#94
AROCLOR 1254 MAY INDUCE LONG-TERM
ALTERATIONS IN CENTRAL VASOPRESSIN
RELEASE BY INHIBITING NITRIC OXIDE
SYNTHESIS WITHIN THE SUPRAOPTIC
NUCLEUS. C. G. Coburn1, B. Hou2, L. Lin2, C.
Cheetham2, E. R. Gillard2, O. Loson2, D. Prodon2
and M. C. Curras-Collazo2, 1. 1Environmental
Toxicology, UC Riverside, Riverside, CA and 2Cell
Biology and Neuroscience, UC Riverside, Riverside,
CA.
#87
THYROID HORMONE RECEPTOR-α IS
NOT RESPONSIBLE FOR TCDD-MEDIATED
IMMUNOTOXICITY AND WASTING
SYNDROME. C. P. Curran, T. P. Dalton, M.
L. Miller, G. D. Leikauf and D. W. Nebert.
Environmental Health, University of Cincinnati,
Cincinnati, OH.
#95
#88
EFFECTS ON BONE TISSUE IN MALE AND
FEMALE TRANSGENIC MICE EXPRESSING
A CONSTITUTIVELY ACTIVE ARYL
HYDROCARBON RECEPTOR. C. I. Wejheden1,
S. Brunnberg1, A. Hanberg1, C. Ohlsson2 and M.
P. Lind1. 1Institute of Environmental Medicine,
Karolinska Institutet, Stockholm, Sweden and
2
Department of Internal Medicine, Gothenburg
University, Gothenburg, Sweden.
HEPATIC GENE EXPRESSION PROFILING
OF FEMALE RATS CHRONICALLY
EXPOSED TO PCB 126, PCB 153, OR A
BINARY MIXTURE OF PCB 126 AND PCB 153.
K. M. Kransler1, B. J. Ovando1, R. J. Foxenberg1,
C. M. Vezina2 and J. R. Olson1. 1Pharmacology &
Toxicology, SUNY at Buffalo, Buffalo, NY and
2
Pharmacy, University of Wisconsin, Madison, WI.
#96
STRUCTURE ACTIVITY ANALYSIS OF
THE INHIBITION OF ALKOXYRESORUFIN
O-DEALKYLATION ACTIVITIES BY
TETRACHLOROBIPHENYLS. P. Edwards and
S. Bandiera. Faculty of Pharmaceutical Sciences,
University of British Columbia, Vancouver, BC,
Canada.
#97
REGULATION OF CYCLOOXYGENASE-2
IN GRANULOCYTIC HL-60 CELLS BY 2, 2´,
4, 4´-TETRACHLOROBIPHENYL INVOLVES
TRANSCRIPTIONAL CHANGES AND
CHANGES IN mRNA STABILITY. S. Bezdecny1,
2, 3
, R. A. Roth1, 2, 3 and P. E. Ganey1, 2, 3. 1Department
of Pharmacology and Toxicology, Michigan
State University, East Lansing, MI, 2Center for
Integrative Toxicology, Michigan State University,
East Lansing, MI and 3National Food Safety and
Toxicology Center, Michigan State University, East
Lansing, MI.
#98
2, 3, 7, 8-TETRACHLOROPHENOTHIAZ
INE: A POTENT ARYL HYDROCARBON
RECEPTOR LIGAND. K. W. Fried1, R. M. Bazzi2,
D. R. Bell2 and K. K. Rozman1, 3. 1Department
of Pharmacology, Toxicology & Therapeutics,
University of Kansas Med. Ctr., Kansas City,
KS, 2Molecular Toxicology, School of Biology,
University of Nottingham, Nottingham, United
Kingdom and 3Section of Environmental Toxicology,
Institute for Toxicology, GSF-National Research
Center for Environment and Health, Neuherberg,
Germany.
#99
DO THE EPIDERMAL TISSUES OF
HUMANS PROVIDE A SUBSTANTIAL
SINK AND EXCRETION PATHWAY FOR
MORE PERSISTENT POLYCHLORINATED
BIPHENYLS AND DIOXINS? B. D. Kerger1
and R. C. James2. 1HSRI, Inc., Tallahassee, FL and
2
TERRA, Tallahassee, FL.
#100
DISPOSITION OF A MIXTURE OF
POLYBROMINATED DIPHENYL ETHERS
(PBDES) IN MALE F344 RATS. E. H. Lebetkin, J.
M. Sanders, L. Chen, A. C. Creech and L. T. Burka.
LPC, NIEHS, Research Triangle Park, NC.
#89
SHORT-TIME EXPOSURE TO DIOXIN
IMPAIRS TRABECULAR BONE TISSUE
IN MALE SPRAGUE/DAWLEY RATS. R.
Lundberg1, C. Wejheden1, F. Moncek2, A. Rannug2
and M. Lind1. 1Division of Biochemical Toxicology,
Institute of Environmental Medicine, Karolinska
Institutet, Stockholm, Sweden and 2Division of Work
Environment Toxicology, Institute of Environmental
Medicine, Karolinska Institutet, Stockholm, Sweden.
#90
DIOXIN LEVELS IN VIETNAMESE
POTENTIALLY EXPOSED TO AGENT
ORANGE: UPDATE 2006. O. Paepke3, A. J.
Schecter1, H. T. Quynh2, J. D. Constable4 and K.
Tung1. 1Environmental Sciences, University of Texas
School of Public Health, Dallas, TX, 2Institute for
Sustainable Agriculture, Hanoi, Viet Nam, 3Eurofin
ERGO Research, Hamburg, Germany and 4Harvard
Medical School, Boston, MA.
#91
CAVEOLIN-1 PLAYS A ROLE IN PCBINDUCED VASCULAR ENDOTHELIAL CELL
INFLAMMATION. Z. Majkova, X. Arzuaga,
E. Lim, E. Smart, M. Toborek and B. Hennig.
University of Kentucky, Lexington, KY.
#92
INDUCTION OF OXIDATIVE STRESS,
DNA DAMAGE, AND CELL TOXICITY BY
POLYCHLORINATED BIPHENOLS (PCBs)
IN HUMAN BREAST CANCER CELLS. P. Lin,
C. Huang and C. Lin. Environmental Engineering,
National Chung Hsing University, Taichung, Taiwan.
#93
POLYCHLORINATED BIPHENYLS (PCBs)
MODULATE THE INDUCTION OF CELL
TOXICITY, ROS FORMATION, AND DNA
DAMAGE BY 17β-ESTRADIOL IN HUMAN
BREAST CARCINOMA CELLS. C. Lin, Y. Chou
and P. Lin. Environmental Engineering, National
Chung Hsing University, Taichung, Taiwan.
67
MONDAY
45th Annual
Meeting & ToxExpo
#101
IMMUNOMODULATION BY
PERFLUOROOCTANESULFONATE (PFOS)
IN A 28-DAY RAT FEEDING STUDY. G. S.
Bondy, I. Curran, L. Coady, C. Armstrong, M.
Parenteau, V. Liston, L. Hierlihy and J. Shenton.
Toxicology Research Division, Food Directorate,
Health Canada, Ottawa, ON, Canada.
#102
PERFLUOROOCTANESULFONATE (PFOS)
TOXICITY IN THE RAT: A 28-DAY FEEDING
STUDY. I. Curran, G. Bondy, V. Liston, L. Hierlihy,
L. Coady and S. Gurofsky. Toxicology Research
Division, Food Directorate, Health Canada, Ottawa,
ON, Canada.
#103
PERFLUOROOCTANE SULFONIC ACID
ALTERS HUMAN NEUTROPHIL FUNCTION.
M. Moreno-Contreras2, 1 and J. Olivero-Verbel1.
1
Environmental and Computational Chemistry
Group, University of Cartagena, Cartagena,
Colombia and 2Master’s Degree Program in
Microbiology, University of Cartagena, Cartagena,
Colombia.
#104
MONDAY
#105
#106
#107
#108
OCTANOL-WATER PARTITION
COEFFICIENTS CAN PREDICT THE
PARTITION OF POPS FROM SERUM TO
BREAST MILK. K. Inoue1, K. Harada1, K.
Takenaka2, M. Kono3, T. Shimizu4, S. Uehara5,
T. Takasuga6 and A. Koizumi1. 1Health and
Environmental Sciences, Kyoto University, Kyoto,
Japan, 2Takayama Red Cross Hospital, Takayama,
Japan, 3Kono Hospital, Hokkaido, Japan, 4Shimizu
Hospital, Hyogo, Japan, 5Tohoku Kosai Hospital,
Sendai, Japan and 6R & D, Shimadzu TechnoResearch, Inc., Kyoto, Japan.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: CHILDREN’S HEALTH AND JUVENILE
ANIMAL TOXICITY
Chairperson(s): Charles Smith, Columbus Children, Columbus, OH and
Mingyue Ma, Hokkaido University School of Medicine, Sapporo, Japan.
PERFLUOROOCTANE SULFONATE
INCREASES THE ANGLE OF CILIARY
MOVEMENT OF TRACHEAL CELLS IN
MICE. E. Matsubara1, M. Kinboshi1, T. Nakahari2
and A. Koizumi1. 1Department of Health and
Japan and 2Department of Physiology, Osaka
Medical College, Takatsuki, Japan.
CENTRALLY ADMINISTERED
PERFLUOROOCTANE SULFONATE (PFOS)
DECREASES FOOD INTAKE IN MICE. A.
Asakawa, E. Matsubara, M. Kinboshi, K. Harada,
K. Inoue and A. Koizumi. Department of Health and
Japan.
STRUCTURE ACTIVITY RELATIONSHIP
OF EFFECTS OF PERFLUORINATED
AMPHIPHILES ON BACKWARD SWIMMING
IN PARAMECIUM CAUDATUM. E. Matsubara,
K. Harada, K. Inoue and A. Koizumi. Department
of Health and Environmental Sciences, Kyoto
University, Kyoto, Japan.
ASSESSMENT OF THE INTAKE OF METHYL
MERCURY THROUGH DIETS AMONG
GENERAL POPULATION IN JAPAN. Y.
Wada1, 3, A. Koizumi2, 3, K. Inoue2, 3, K. Harada2, 3,
S. Inoue2, 3, S. Fujii3, N. Hachiya4, 3, I. Hirosawa3,
S. Koda3, Y. Kusaka3, K. Murata3, H. Nakatsuka3,
K. Omae3, N. Saito3, S. Shimbo3, K. Takenaka3,
T. Takeshita3, H. Todoriki3, T. Watanabe3 and M.
Ikeda3. 1Environmental and Preventive Medicine,
Hyogo College of Medicine, Nishinomiya, Japan,
2
Kyoto University Graduate School of Medicine,
Kyoto, Japan, 3Sample Banking Project for POPs
Monitoring, Kyoto, Japan and 4National Institute for
Minamata Disease, Minamata, Japan.
68
#109
IDENTIFICATION OF CHEMICALS
RELEASED BY PLAYGROUND SURFACES
MADE OF RECYCLED TIRES. C. Vidair1,
M. Petreas2, J. Garcha2 and R. Schlag1. 1Office
of Environmental Health Hazard Assessment,
California Environmental Protection Agency,
Oakland, CA and 2Department of Toxic Substances
Control, California Environmental Protection
Agency, Berkeley, CA. Sponsor: R. Howd.
#110
CHILD-SPECIFIC REFERENCE VALUES TO
ASSESS HEALTH RISK AT CALIFORNIA
SCHOOL SITES. D. Chan, S. Knadle, S. Camacho
and D. Siegel. Cal/EPA, OEHHA, Sacramento, CA.
#111
SEARCH FOR PLASMA PROTEIN
BIOMARKER FOR AUTISM
USING DIFFERENTIAL IN-GEL
ELECTROPHORESIS. H. V. Aposhian, R. A.
Zakharyan, Universtiy of. K. Chowdhury and M. D.
Avram. Molecular and Cellular Biology Department,
University of Arizona, Tucson, AZ.
#112
LEAD EXPOSURE IN NEWBORN CHILDREN
LIVING IN A SMELTER COMMUNITY
IN REGION LAGUNERA, MEXICO. M. C.
Hernandez-Serrano2, E. Zermeno-Gonzalez3, M.
De la Rosa3, V. Lujan-Galvan4, A. Torres-Vega4, J.
Garcia-Salcedo2, M. Rubio-Andrade1, M. GuerreroAlmeida1 and G. G. Garcia-Vargas1. 1Facultad de
Medicina, Investigacion, Universidad Juarez del
Estado de Durango, Gómez Palacio, Durango,
Mexico, 2Facultad de Medicina, UAC, Torreon,
Coahuila, Mexico, 3ISSSTE, Torreon, Coahuila,
Mexico and 4Programa Metales, SSA, Torreon,
Coahuila, Mexico.
#113
CHEMICAL-DEPENDENT VARIABILITY
IN EARLY LIFE SENSITIVITY TO
CARCINOGENS. M. S. Sandy, C. D. Sherman,
R. S. Tomar and L. Zeise. Office of Environmental
Health Hazard Assessment, Oakland, CA.
45th Annual
Meeting & ToxExpo
#114
#115
AGE RELATED DIFFERENCES IN
SECONDARY MALIGNANCIES IN
CHILDREN: LESSONS LEARNED FROM
THE PEDIATRIC CLINICAL EXPERIENCE.
D. Pyatt1, 2 and S. Hays1. 1Summit Toxicology,
Lafayette, CO and 2MTEHS, University of
Colorado, Denver, CO.
ANALYSIS OF THE SPATIAL PROXIMITY
OF CHILDHOOD LEUKEMIA TO HIGH
DENSITY ROADS IN UTAH. S. LeFevre and W.
Ball. Environmental Epidemiology Program, Utah
Department of Health, Salt Lake City, UT.
#116
IMPLICATIONS OF CHILDHOOD ACUTE
LYMPHOCYTIC LEUKEMIA STUDIES FOR
CHILDREN’S HEALTH RISK ASSESSMENT.
A. S. Kim. U.S. EPA, Washington, DC. Sponsor: S.
Barone.
#117
PHYSIOLOGICAL DAILY INHALATION
RATES FOR FREE-LIVING INDIVIDUALS
AGED 1 MONTH TO 96 YEARS. P. Brochu1, 2,
J. Ducre-Robitaille1 and J. Brodeur2. 1Ministry of
Sustainable Development, Environment and Parks,
Quebec Government, Quebec, Canada and 2Faculty
of medicine, University of Montréal, Montréal, QC,
Canada.
#118
HEAVY METALS IN HUMAN COLOSTRAL
BREAST MILK AND MATERNAL SMOKING
EFFECTS IN ISTANBUL –TURKEY. H. Gul1,
A. Onen2, G. Gungor1, A. Ozden3, S. Ozel4 and
L. Ibrahimoglu5. 1Department of Public Health,
Istanbul Medical Faculty, Istanbul, Turkey, 2Turk
Henkel, Reseach&Development, Istanbul, Turkey,
3
Institute of Child Health, Trace Element Laboratory,
Istanbul, Turkey, 4Department of Biostatistics,
Istanbul Faculty of Medicine, Istanbul, Turkey and
5
Department of Obstetrics and Gynecology, Istanbul
Faculty of Medicine, Istanbul, Turkey.
#119
#120
#121
THE EFFECTS OF INHALATION EXPOSURE
OF DI-2-ETHYLHEXYLPHATHALATE
(DEHP) ON THE ONSET OF PUBERTY
AND POSTPUBERTAL REPRODUCTIVE
FUNCTIONS IN PREPUBERTAL FEMALE
RATS. M. Ma, T. Kondo, T. Umemura, N. Kurahashi
and R. Kishi. Department of Public Health,
HokkaidoUniversity School of Medicine, Sapporo,
Japan. Sponsor: W. Zheng.
META-ANALYSIS ON CANCER SENSITIVITY
DUE TO AGE AT EXPOSURE TO DIRECT
ACTING ETHYLNITROSOUREA. R. S. Tomar,
M. S. Sandy, C. D. Sherman and L. Zeise. OEHHA,
California EPA, Oakland, CA.
#123
OXIDANT RESPONSES IN LPS-INDUCED
PRETERM BIRTH IN MICE. C. V. Smith, K.
M. Heyob, F. A. Jenniskens, S. E. Welty and L. K.
Rogers. Pediatrics, Columbus Children’s Research
Institute, Columbus, OH.
#124
EVALUATION OF THE AGE-DEPENDENT
NEPHROTOXICITY OF GENTAMICIN
USING GENE EXPRESSION BIOMARKERS.
B. A. Rosenzweig, K. Thompson, J. Hanig and P.
Espandiari. DAPR, CDER, USFDA, Silver Spring,
MD.
#125
CHARACTERIZATION OF A RODENT
PEDIATRIC NEPHROTOXICITY MODEL.
P. Espandiari1, T. Miller1, J. Zhang1, A. Knapton1,
P. Goering2, R. Brown2, V. Vaidya3, A. Johnson3,
J. Bonventre3, B. Rosenzweig1, K. Thompson1, P.
Pine1, L. Schnackenberg4, R. Beger4, E. Herman1,
J. Weaver1 and J. Hanig1. 1CDER, USFDA, Silver
Spring, MD, 2CDRH, USFDA, Silver Spring, MD,
3
Renal Division, Harvard Medical School, Boston,
MA and 4Division of Systems Toxicology, NCTR,
Jefferson, AR.
#126
POTENTIAL MODEST PROTECTIVE
EFFECT OF MIDAZOLAM ON KETAMINEINDUCED APOPTOSIS IN RAT FOREBRAIN
CULTURE. N. Sadovova2, X. Zou1, A. Scallet1,
T. Patterson1, J. Hanig3, M. Paule1, W. Slikker1 and
C. Wang1. 1Division of Neurotoxicology, NCTR/
U.S. FDA, Jeferson, AR, 2Toxicologic Pathology
Associates, Jefferson, AR and 3CDER/U.S. FDA,
Rockville, MD.
#127
CYTOTOXCITY AND MUTAGENICITY
IN HUMAN TK6 LYMPHOBLASTOID
CELLS EXPOSED IN VITRO TO
METHYLPHENIDATE. M. M. Carter, V. E.
Walker, C. L. McCash and D. M. Walker. Cancer,
LRRI, Albuquerque, NM.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
EFFECT OF PHENOBARBITAL ON SERUM
TESTOSTERONE CONCENTRATION IN
JUVENILE RATS. R. Itamura, Y. Asaoka, M.
Horimoto and I. Horii. Worldwide Safety Sciences,
Pfizer Global Research & Development, Nagoya
Laboratories, Pfizer Inc., Aichi, Japan. Sponsor: M.
Kurata.
POSTER SESSION: DEVELOPMENTAL TOXICITY IN IN VIVO
AND IN VITRO SYSTEMS
Chairperson(s): Janice Lansita, Biogen Idec, Cambridge, MA and Stacey
Harper, Oregon State University, Corvallis, OR.
THE EFFECT OF ENVIRONMENTAL
TOBACCO SMOKE ON LYMPHOCYTE
INFILTRATION IN THE LUNG. A. Ross and
J. Peake. Center for Health & the Environment,
University of California, Davis, Davis, CA. Sponsor:
K. Pinkerton.
#122
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69
HUMAN DIETARY ALKALOIDS INHIBIT
HEDGEHOG SIGNALING. R. J. Lipinski, E.
K. Dengler, W. Heideman, R. E. Peterson and W.
Bushman. Molecular and Environmental Toxicology,
University of Wisconsin-Madison, Madison, WI.
MONDAY
45th Annual
Meeting & ToxExpo
#129
DEVELOPMENTAL TOXICITY OF
PENTAERYTHRITOL ESTERS APPLIED
DERMALLY IN RATS. W. Dalbey1 and M.
Feuston2. 1ExxonMobil Biomedical Sciences, Inc.,
Paulsboro, NJ and 2Sanofi-Aventis, Malvern, PA.
#130
TERATOLOGY STUDY OF DIBUTYLTIN IN
CYNOMOLGUS MONKEYS GIVEN DURING
ORGANOGENESIS. M. Ema1, K. Fukunishi2, M.
Matsumoto1, A. Hirose1, E. Kamata1, A. Arima2 and
T. Ihara2. 1Risk Assessment, National Institute of
Health Sciences, Tokyo, Japan and 2Shin Nippon
Biomedical Laboratories, Ltd., Kagoshima, Japan.
MONDAY
#131
THE MINIPIG IN DEVELOPMENTAL
TOXICITY STUDIES. A. Makin, T. Kledal and A.
Christensen. Toxicology and Pharmacology, Scantox
A/S, Lille Skensved, Denmark. Sponsor: R. Harling.
#132
DEVELOPMENTAL REPRODUCTION
TOXICITY STUDY OF ALEFACEPT. J. A.
Lansita1, C. Tenhoor1, J. Rutkowski2, D. Hutto1,
V. Palmer1, C. Graff1, I. Osterburg3, A. Vu4
and J. Clarke1. 1Biogen Idec, Cambridge, MA,
2
Preclinical Pharmacology and Toxicology, Predix
Pharmaceuticals, Lexington, MA, 3Covance
Laboratories, Muenster, Germany and 4Covance
Laboratories, Chantilly, VA.
#133
EVALUATION OF THE DEVELOPMENTAL
TOXICITY POTENTIAL OF LENALIDOMIDE
IN RABBITS. M. Christian1, S. Teo2, O. Laskin2,
V. Sharper3, D. Stirling2 and L. Latriano2. 1Argus
International, Horsham, PA, 2Celgene Corporation,
Summit, NJ and 3Charles River Laboratories
Preclinical Services, Horsham, PA.
#134
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#136
XMP.629, A NOVEL ANTIMICROBIAL
PEPTIDOMIMETIC FOR THE TREATMENT
OF MILD TO MODERATE ACNE
VULGARIS: EVALUATION OF POTENTIAL
DEVELOPMENTAL EFFECTS OF XMP.629
IN SPRAGUE-DAWLEY RATS AND NEW
ZEALAND WHITE RABBITS. C. Gasper1, B.
Thorsrud2, R. Hawks1, J. Tibbitts1 and K. Meyer1.
1
Preclinical Research, XOMA (US) LLC, Berkeley,
CA and 2Discovery and Development Services,
Charles River Laboratories, Spencerville, OH.
COMPARING IMMUNOTOXICITY IN
RATS AFTER IN UTERO VERSUS AN
ADULT EXPOSURE: IS DEVELOPMENTAL
EXPOSURE MORE SENSITIVE? K. Goff1, W.
Williams2 and R. Smialowicz2. 1Toxicology, UNC
Chapel Hill, Chapel Hill, NC and 2ORD/NHEERL/
ETD/ITB, University of S. EPA, Research Triangle
Park, NC.
COMPARISON OF BIRTH DEFECT
REDUCTION DUE TO NON-SPECIFIC
IMMUNE STIMULATION WITH IFNGAMMA IN C57BL/6N AND CD-1
METHYLNITROSOUREA-EXPOSED MICE.
C. Laudermilch1, S. D. Holladay1, D. P. Sponenberg1,
G. K. Saunders1, D. L. Ward1 and M. R. Prater2,
1 1
. DBSP, Virginia-Maryland Regional College
of Veterinary Medicine, Blacksburg, VA and
2
Biomedical Sciences, Edward via Virginia College
of Osteopathic Medicine, Blacksburg, VA.
70
#137
CHARACTERIZING THE ROLE OF
MATERNAL DIETARY ANTIOXIDANTS IN
IMMUNE REGULATION AND PLACENTAL
AND DISTAL LIMB DEVELOPMENT IN THE
MOUSE MODEL. M. R. Prater1, 2, L. C. Pinn2, A.
E. Flood2, C. L. Laudermilch2, A. E. Tanner2 and
S. D. Holladay2. 1Virginia College of Osteopathic
Medicine, Blacksburg, VA and 2Virginia Tech,
Blacksburg, VA.
#138
MEDAKA FISH AS A MODEL FOR
DEVELOPMENTAL ETHANOL TOXICITY:
ASSESSING PERIODS OF HEIGHTENED
SENSITIVITY. S. Oxendine2, 1, D. Hinton3,
J. Cowden1 and S. Padilla1, 2. 1NTD, U.S. EPA,
Research Triangle Park, NC, 2Curr. in Toxicol.,
UNC-CH, Chapel Hill, NC and 3Nicholas School of
the Environment, Duke University, Durham, NC.
#139
TERATOGENIC EFFECTS OF ETHANOL
ON THE CORTICAL HEM. E. A. Myers1, 4, T. A.
Wills2, 4, D. B. Dehart3, 4, S. E. Parnell3, 4 and K. K.
Sulik3, 4. 1Curriculum in Toxicology, University of
North Carolina, Chapel Hill, NC, 2Curriculum in
Neurobiology, University of North Carolina, Chapel
Hill, NC, 3Department of Cell and Developmental
Biology, University of North Carolina, Chapel
Hill, NC and 4Bowles Center for Alcohol Studies,
University of North Carolina, Chapel Hill, NC.
#140
EFFECT ON F1 GENERATION BEING BORN
FROM MICE TREATED WITH RETINOIC
ACID DURING GESTATION. N. Makoto1,
F. Hideki1, 2, M. Yoshiharu1, 2 and M. Chisato1, 2.
1
Graduate School of Medicine, Chiba University,
Department of Bioenvironmental Medicine, CHIBAKEN, Japan and 2Graduate School of Medicine,
Chiba University, Environmental Health Science
Project for Future Generations, CHIBA-KEN, Japan.
#141
INVESTIGATION OF VALPROIC ACID
TOXICITY IN THE GESTATION DAY 9
MOUSE FETUS USING AN INTEGRATED
GENOMICS APPROACH. M. F. DeCristofaro1, M.
O’Hara2, M. Letzkus3, A. Cordier4, S. Bongiovanni3,
S. Chibout3, D. Beckman2 and F. Staedtler3.
1
Biomarker Development, Novartis Pharmaceuticals,
East Hanover, NJ, 2Safely Profiling and Assessment,
Novartis Pharmaceuticals, East Hanover, NJ,
3
Biomarker Development, Novartis Pharma
AG, Basel, Switzerland and 4Safely Profiling
and Assessment, Novartis Pharma AG, Basel,
Switzerland.
#142
ESTABLISHING PREDICTIVE MOLECULAR
MARKERS OF DIFFERENTIATION AS
TOXICOLOGICAL ENDPOINTS IN THE
EMBRYONIC STEM CELL TEST (EST). J.
Kaltenhaeuser1, R. Buesen2, E. Genschow2, A.
Visan2, B. Slawik2, K. Schlechter2, K. Becker1, T.
Steger-Hartmann1, H. Spielmann2 and A. Seiler2.
1
Experimental Toxicology, Schering AG, Berlin,
Germany and 2National Center for Documentation
and Evaluation of Alternative Methods to Animal
Experiments (ZEBET), Federal Institute for Risk
Assessment (BfR), Berlin, Germany. Sponsor: K.
Riecke.
45th Annual
Meeting & ToxExpo
#143
#144
#145
ENVIRONMENTALLY-RELEVANT
TRICHLOROETHYLENE EXPOSURE
ALTERS CARDIAC HEMODYNAMICS
DURING AviaN DEVELOPMENT. V. J. Drake1,
J. Lough2, N. Hu3, 4 and S. M. Smith1. 1Department
of Nutritional Sciences, University of WisconsinMadison, Madison, WI, 2Department of Cell
Biology, Anatomy and Neurobiology, Medical
College of Wisconsin, Milwaukee, WI, 3Department
of Pediatrics, University of Utah, Salt Lake City, UT
and 4Primary Childrens Medical Center, Salt Lake
City, UT. Sponsor: R. Hines.
EXAMINATION OF THE CRITICAL WINDOW
FOR LOW DOSE TRICHLOROETHYLENE
EXPOSURE TO CHICK EMBRYOS. E. S.
Rufer1, V. Drake1, J. Lough2 and S. M. Smith1.
1
Nutritional Sciences, University of Wisconsin
- Madison, Madison, WI and 2Medical College of
Wisconsin, Milwaukee, WI. Sponsor: C. Jefcoate.
ASSESSING THE TOXIC POTENTIAL OF
ACUTE EXPOSURE TO ENGINEERED
NANOMATERIALS. S. L. Harper and R. L.
Tanguay. Environmental and Molecular Toxicology,
Oregon State University, Corvallis, OR.
#146
EFFECT OF 8-MOP ON DEVELOPMENT OF
FROG EMBRYO. C. L. Osborne, J. Cozzetta and
M. M. Diawara. Biology, Colorado State UniversityPueblo, Pueblo, CO.
#147
CELL DEATH AND HSP70/EGFP
EXPRESSION IN THE DEVELOPING
OLFACTORY SYSTEM OF ZEBRAFISH
LARVAE FOLLOWING CADMIUM
EXPOSURE. C. J. Matz and P. H. Krone. Anatomy
and Cell Biology, University of Saskatchewan,
Saskatoon, SK, Canada. Sponsor: P. Devine.
#148
#149
#150
TOXIC EFFECTS OF LOW LEVELS
OF DIMETHYL SULFOXIDE DURING
EMBRYONIC DEVELOPMENT IN MEDAKA
(ORYZIAS LATIPES). J. Cowden1, S. Oxendine2,
1
, D. Hinton3 and S. Padilla1, 2. 1Neurotoxicology
Division, U.S. EPA, Research Triangle Park,
NC, 2Curriculum in Toxicology, University of
North Carolina - Chapel Hill, Chapel Hill, NC
and 3Nicholas School of the Environment, Duke
University, Durham, NC.
MATRIX METALLOPROTEINASE
EXPRESSION AND FUNCTION DURING
ZEBRAFISH EMBRYOGENESIS:
ANALYSIS OF MMP-2, MMP-9, AND
MMP-13 FOLLOWING EXPOSURE TO
DEXAMETHASONE OR HYDROCORTISONE.
J. M. Hillegass, C. M. Villano, L. A. White and K.
R. Cooper. Joint Graduate Program in Toxicology,
Rutgers, The State University of New Jersey,
Piscataway, NJ.
#152
DISCORDANT PHENOTYPES
OF GENETICALLY DIVERGENT
ZEBRAFISH EXPOSED TO 3, 3’, 4, 4’, 5PENTACHLOROBIPHENYL (PCB126). E.
Waits. U.S. EPA, Cincinnati, OH. Sponsor: T. Reddy.
#153
COMPARISON OF THE EFFECTS OF 3
PLANT ALKALOIDS ON THE DEVELOPING
CHICK EMBRYO AND FRUIT FLY LARVAE.
K. Lustofin and B. Francis. Entomology, University
of Illinois at Urbana-Champaign, Urbana, IL.
#154
CATALASE SIGNIFICANTLY PROTECTS
AGAINST VALPROIC ACID INDUCED
NEURAL TUBE DEFECTS IN CD-1 MOUSE
EMBRYOS IN CULTURE. E. W. Tung1 and L. M.
Winn1, 2. 1Pharmacology and Toxicology, Queen’s
University, Kingston, ON, Canada and 2School
of Environmental Studies, Queen’s University,
Kingston, ON, Canada.
#155
EFFECTS OF TCDD ON MOUSE
EMBRYONIC STEM CELLS IN CULTURE.
A. TAKAGI and J. KANNO. Cellular & Molecular
Toxicology, National Institute Health Sciences,
Tokyo, Japan. Sponsor: A. Takagi.
#156
INHIBITION OF MOUSE KIDNEY
DEVELOPMENT BY BENZO(A)PYRENE:
INVOLVEMENT OF ARYL HYDROCARBON
RECEPTOR AND WILMS’ TUMOR
SUPPRESSOR GENE. A. Nanez and K. S. Ramos.
Biochemistry and Molecular Biology, University of
Louisville, Louisville, KY.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: BIOMARKERS
EXPRESSION OF THE HELIX-LOOPHELIX INHIBITOR OF DNA BINDING-6
(ID-6) GENE IS INDUCED BY ALL-TRANS
RETINOIC ACID IN ZEBRAFISH EMBRYOS.
C. Villano1, 2, J. Hillegass1, 2 and L. White2, 1. 1Joint
Graduate Program in Toxicology, Rutgers, The
State University of New Jersey, Piscataway, NJ and
2
Biochemistry and Microbiology, Rutgers, The State
University of New Jersey, New Brunswick, NJ.
Chairperson(s): Timothy Fennell, RTI, Research Triangle Park, NC and M.
Firoze Khan, University of Texas Medical Branch, Galveston, TX.
#157
ETHANOL PERTURBS ALCOHOL
DEHYDROGENASE ENZYME EXPRESSION
IN JAPANESE MEDAKA EMBRYO. A. K.
Dasmahapatra1, 2, X. Wang2, 1 and M. L. Haasch1,
2 1
. National Center for Natural Product Research,
2
Department of Pharmacology, University of
Mississippi, University, MS.
#151
71
GENE EXPRESSION ALTERATIONS
OBSERVED IN PRIMARY CULTURED RAT
HEPATOCYTES AFTER TREATMENT WITH
CHLORINATED OR CHLORINATED AND
OZONATED DRINKING WATER. L. M. Crosby1,
T. M. Moore2, J. Simmons2 and A. B. DeAngelo2.
1
U.S. EPA/UNC Coop. Training Progr., Chapel
Hill, NC and 2NHEERL, ORD, U.S. EPA, Research
Triangle Pk, NC.
MONDAY
45th Annual
Meeting & ToxExpo
#158
METABONOMICS OF A RODENT
PEDIATRIC NEPHROTOXICITY MODEL. L.
K. Schnackenberg1, P. Espandiari2, P. S. Pine2, R.
Anderson2, R. D. Beger1 and J. Hanig2. 1Systems
Toxicology, National Center for Toxicological
Research, Jefferson, AR and 2CDER, USFDA, Silver
Spring, MD.
#165
METABONOMIC EVALUATION OF
SCHAEDLER ALTERED MICROFLORA
RATS. D. Wells1, L. C. Robosky1, D. G. Robertson1
and C. C. Clifford2. 1Metabonomics Evaluation
Group, Pfizer Global Research & Development,
Ann Arbor, MI and 2Charles River Laboratories,
Wilmington, MA.
#159
METABONOMICS INVESTIGATION OF
CISPLATIN TOXICITY IN SPRAGUEDAWLEY RAT AND B6C3F1 MOUSE. K.
Okamoto1, 2, W. W. Collette2, B. Sadri3, X. Liao3,
G. J. Stevens2 and A. Deese3. 1Graduate School of
Public Health, San Diego State University, San
Diego, CA, 2Worldwide Safety Sciences, Pfizer
Inc., La Jolla, CA and 3Analytical Research and
Development, Pfizer Inc., La Jolla, CA.
#166
KINETICS OF ELIMINATION OF URINARY
METABOLITES OF ACRYLAMIDE IN
HUMANS. T. Fennell1, R. W. Snyder1, S. C.
Sumner1, J. Burgess1 and M. A. Friedman2. 1RTI
International, Research Triangle Park, NC and
2
UMDNJ, Newark, NJ.
#167
EXTREMELY SENSITIVE BIOMARKER
OF ACUTE ORGANOPHOSPHORUS
INSECTICIDE EXPOSURE. Y. Fujikawa1, A.
Suganuma1 and T. Satoh2, 3. 1Drug Safety Research
Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki,
Japan, 2HAB Research Laboratories, Ichikawa,
Chiba, Japan and 3Chiba University, Chiba, Japan.
#168
PLACENTAL GENE EXPRESSION
IN RESPONSE TO HIGH LEVELS OF
UNCONJUGATED GENISTEIN IN PLACENTA
OF RATS ADMINISTERED GENISTEIN. N. V.
Soucy, H. D. Parkinson and S. J. Borghoff. Division
of Biological Sciences, CIIT Centers for Health
#169
HEPATIC TRANSCRIPTOME
DIFFERENTIATES A SELECTIVE PDE4
INHIBITOR AND IDENTIFIES A POSSIBLE
MECHANISM OF ACUTE PHASE RESPONSE
(APR) DUE TO LOSS OF INTESTINAL
PERMEABILITY. R. Eyre1, G. Dietsch1, S.
Tugendreich3, K. L. Kolaja4 and M. R. Fielden2.
1
Preclinical Studies, ICOS, Bothell, WA, 2Iconix, Mt
View, CA, 3Merck, Seattle, WA and 4Roche, Palo
Alto, CA.
#170
IDENTIFICATION OF GENE EXPRESSION
CHANGES IN PERIPHERAL BLOOD
MONONUCLEAR CELLS INDICATIVE
OF EXPOSURE TO CHEMICALS WITH
DIFFERENT TARGET ORGAN TOXICITY.
V. Chan1, A. R. Stapleton1, A. Soto2, K. Yu2 and N.
DelRaso2. 1Alion Science & Technology, Dayton,
OH and 2AFRL, Wright-Patterson AFB, OH.
#171
GENE EXPRESSION CHANGES ASSOCIATED
WITH ADRENAL TOXICITY IN RATS
TREATED WITH VEGFR2 INHIBITORS. M.
A. Higgins1, M. Todd1, M. Damore2, C. A. Afshari1
and H. K. Hamadeh1. 1Comparative Biology and
Safety Sciences, Amgen Inc., Thousand Oaks, CA
and 2Medical Sciences, Amgen Inc., Thousand Oaks,
CA.
#160
#161
MONDAY
#162
#163
#164
METABOLOMIC ANALYSES OF CHINOOK
SALMON SMOLTS EXPOSED TO CRUDE
OIL OR DISPERSED OIL. C. Lin1, M. Viant2,
B. Anderson1 and R. Tjeerdema1. 1Environmental
Toxicology, University of California, Davis, Davis,
CA and 2School of Biosciences, University of
Birmingham, Birmingham, United Kingdom.
RENAL PAPILLARY NECROSIS-INDUCED
METABOLIC ALTERATIONS IN BIOFLUIDS
AND TISSUES USING NMR AND UPLC-MS
TECHNOLOGIES. M. Coen1, J. T. Pearce1,
N. Aranibar2, H. Zhang2, G. H. Cantor2, L. D.
LehmanMcKeeman2, V. Roongta2, M. Sanders2,
H. C. Keun1, E. Holmes1, J. C. Lindon1 and J.
K. Nicholson1. 1Biological Chemistry, Imperial
College, London, United Kingdom and 2Discovery
Toxicology, Bristol-Myers Squibb, Lawrenceville,
NJ.
METABOLOMIC ANALYSIS OF ALCOHOL
TOXICITY IN RAT BRAIN AND LIVER. I.
Shah1, I. Rusyn2, J. Cai1, A. Maki2, D. Kim2, L. Qin2,
J. Corbell1, F. T. Crews2 and A. Higgins1. 1Icoria,
Inc., Research Triangle Park, NC and 2University of
North Carolina, Chapel Hill, NC.
A METABONOMICS INVESTIGATION OF
THE TESTICULAR TOXICITY INDUCED
BY MALE REPRODUCTIVE TOXICANTS. T.
Yamamoto1, T. Fukushima1, S. Sakemi2, H. Yamada1
and I. Horii1. 1Worldwide Safety Sciences, PGRD
Nagoya Laboratories, Pfizer Inc., Taketoyo, Aichi,
Japan and 2Discovery Technologies, PGRD Nagoya
Laboratories, Pfizer Inc., Taketoyo, Aichi, Japan.
Sponsor: M. Kurata.
METABOLOMICS STUDY OF CISPLATINFED MICE: ROLE OF PPARα R. D. Beger1,
L. Schnackenberg1, M. Ford1, J. Megyesi2, R.
Safirstein2 and D. Portilla2. 1Systems Toxicology,
National Center for Toxicological Research,
Jefferson, AR and 2Internal Medicine, University of
Arkansas for Medical Sciences, Central Arkansas
Veterans Healthcare System, Little Rock, AR.
72
45th Annual
Meeting & ToxExpo
#172
#173
#174
#175
#176
#177
#178
QUANTITATIVE ANALYSIS OF DRUGINDUCED PHOSPHOLIPIDOSIS IN
PRIMARY HEPATOCYTE AND PERIPHERAL
BLOOD MONONUCLEAR CELL CULTURES
USING A PHOSPHOLIPID-CONJUGATED
FLUOROPROBE. R. Morgan1, R. Manoukian2,
S. Kaufman1, G. Elliot2, C. A. Afshari1 and H.
K. Hamadeh1. 1Comparative Biology and Safety
Assessment, Amgen Inc., Thousand Oaks, CA and
2
Medical Sciences, Amgen Inc., Thousand Oaks,
CA.
CASEIN-BASED DIETS ALTER SPRAGUEDAWLEY RAT PHENOTYPES. C. M. Rohde1,
L. C. Robosky1, M. L. Manning2, D. F. Wells1, M.
D. Reily1 and D. G. Robertson1. 1Metabonomics
Evaluation Group, Pfizer, Inc., Ann Arbor, MI and
2
Manpower, Ann Arbor, MI.
IMMUNOHISTOCHEMICAL AND
MALDI-TOF BASED TISSUE IMAGING
REVEAL CHANGES IN THE EXPRESSION,
LOCALIZATION, AND PHOSPHORYLATION
OF ANNEXIN I AND II DURING CHEMICALINDUCED NEPHROCARCINOGENICITY. B.
Leinweber1, N. Ma2, M. S. Chacko2, J. I. Everitt3,
T. J. Monks1 and S. S. Lau1. 1Center for Toxicology,
University of Arizona, Tucson, AZ, 2Division of
Pharmacology/Toxicology, Uof Texas, Austin, TX
and 3GlaxoSmithKline, Research Triangle Park, NC.
ELEVATIONS OF PRO-INFLAMMATORY
CYTOKINES AND DECREASES IN
CARDIOVASCULAR HEMODYNAMICS
FOLLOWING INTRAVENOUS
ADMINISTRATION OF RECOMBINANT
HUMAN ACID SPHINGOMYELINASE
(RHASM) TO ACID SPHINGOMYELINASE
KNOCK-OUT (ASMKO) MICE. J. M. Murray,
A. D’Angona, C. Nickerson, A. Vitsky, M. Hawes,
S. Ryan, P. Ewing, B. Thurberg and L. Andrews.
Pharmacology/Toxicology, Genzyme Corporation,
Framingham, MA.
MOLECULAR TARGETS AND TOXIC
EFFECTS OF MICROCYSTIN-LR IN F344
RATS. M. Billam, Q. Cai, S. Mukhi, L. Tang, R. J.
Kendall and J. Wang. Environmental Toxicology and
The Institute of Environmental and Human Health,
Texas Tech University, Lubbock, TX.
EFFECT OF LOW LEVEL PROLONGED
EXPOSURES OF JP-8 ON THE BIOMARKER
EXPRESSIONS IN THE SKIN OF WISTAR
RATS. R. Babu1, A. Chatterjee2, S. Fulzele2, N.
Verma2 and M. Singh2. 1Auburn University, Auburn,
AL and 2College of Pharmacy, Florida A&M
University, Tallahassee, FL.
DETECTION OF ANEUGENIC AND
CLASTOGENIC AGENTS USING P53 AS A
MARKER OF GENOTOXICITY. H. Camacho,
S. K. Roy and D. A. Eastmond. Environmental
Toxicology Graduate Program, University of
California, Riverside, Riverside, CA.
73
#179
GENE EXPRESSION PROFILES FOR THE
ZUCKER FATTY RAT VERSUS ZUCKER
DIABETIC FATTY RAT ARE HIGHLY
CONSISTENT WITH THOSE OBSERVED IN
HUMAN PATIENTS. D. Patel1, R. Rooney1 and S.
Groom2. 1Genome Explorations, Memphis, TN and
2
Toxicology, Charles River Laboratories Preclinical
Montréal, Senneville, QC, Canada. Sponsor: M.
Vezina.
#180
GENE EXPRESSION PROFILING OF
RAT SKIN EXPOSED TO CUMENE
HYDROPEROXIDE. A. Brys, L. Giannunzio, R.
Jones, M. Hejtmancik, D. Gerken and L. Fomby.
Battelle, Columbus, OH.
#181
PHENOBARBITAL-MEDIATED GENE
EXPRESSION PROFILES IN MOUSE LIVER.
L. Zheng1, A. Williams2, A. Yagminas1, C. Parfett1,
G. Zhou1, G. Douglas1 and C. Yauk1. 1Health
Canada, Environment and Occupational Toxicology
Division, HECSB, Ottawa, ON, Canada and 2Health
Canada, Biostatistics and Epidemiology Division,
HECSB, Ottawa, ON, Canada. Sponsor: R. Moody.
#182
BLOOD AS A TOXICOGENOMIC TISSUE.
C. Pearson, S. Fujimoto, M. Judo, M. Sampson, L.
Brady, G. Napolitano, M. Fielden, K. Kolaja and
D. Halbert. Iconix Pharmaceuticals, Inc., Mountain
View, CA.
#183
GLOBAL PROTEOMIC CHANGES IN MOUSE
LUNG AFTER INHALATION EXPOSURE
TO LIPOPOLYSACCHARIDE (LPS) AND/OR
CIGARETTE SMOKE. D. L. Springer1, R. E.
Johnson2, E. F. Strittmatter1, R. J. Moore1, J. G.
Pounds1, K. M. Lee2 and J. H. Miller3. 1Pacific
Northwest National Laboratory, Richland, WA,
2
Battelle Toxicology Northwest, Richland, WA and
3
Washington State University-TriCities, Richland,
WA.
#184
EXPRESSION OF OSTEOPONTIN BY RAT
ALVEOLAR MACROPHAGES IN VITRO. E.
Bermudez and O. R. Moss. CIIT Centers for Health
#185
ANTIBODIES AGAINST FORMALDEHYDEALBUMIN CONJUGATES IN RATS TREATED
WITH FORMALDEHYDE: POTENTIAL
BIOMARKER OF EXPOSURE. M. Khan, H.
Li, J. Wang and G. Ansari. Pathology, University of
Texas Medical Branch, Galveston, TX.
#186
IDENTIFICATION OF GLUTATHIONE
DEPLETION-RESPONSIVE GENES IN
RAT LIVER USING THE LARGE-SCALE
TOXICOGENOMIC DATABASE. N. Kiyosawa,
A. Ono, T. Miyagishima, T. Urushidani and T.
Nagao. Toxicogenoimcs Project, National Institute
of Biomedical Innovation, Ibaraki, Osaka, Japan.
Sponsor: T. Inoue.
#187
ANALYSIS OF HYDROXYBUTENYLVALINE ADDUCTS IN RATS EXPOSED TO
BUTADIENE. N. I. Georgieva, G. Boysen, K.
Jayaraj, A. Gold and J. A. Swenberg. ESE, University
of North Carolina, Chapel Hill, NC.
MONDAY
45th Annual
Meeting & ToxExpo
#188
#189
#190
#191
BIOMARKERS OF MANGANESE EXPOSURE
IN BAY BRIDGE WELDERS. R. Gwiazda1, H.
A. Roels2, R. Park3, R. Bowler4, R. Lucchini5, 1 and
D. Smith1. 1University of California, Santa Cruz,
Santa Cruz, CA, 2Universite Catholique de Louvain,
Brussels, Belgium, 3NIOSH, Cincinnati, OH, 4San
Francisco State University, San Francisco, CA and
5
University of Brescia, Brescia, Italy.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: PEROXISOME PROLIFERATORS/PPAR
Chairperson(s): Ivan Rusyn, University of North Carolina Chapel Hill,
Chapel Hill, NC and Barbara Abbott, Environmental Protection Agency,
DISPOSITION OF LEAD (PB) IN SALIVA,
BLOOD COMPONENTS, AND TISSUES
FOLLOWING REPEAT ORAL EXPOSURE IN
THE RAT. W. Yantasee, R. A. Gies, H. Wu and C.
Timchalk. Pacific Northwest National Laboratory,
Richland, WA.
ERYTHROCYTES AS A USEFUL
BIOLOGICAL MATRIX FOR ASSESSMENT
OF MANGANESE EXPOSURE AMONG
SMELTING WORKERS. L. Yang1, Y. Jiang2
and W. Zheng3. 1First Affiliated Hospital, Guangxi
Med. University Nanning, China, 2Department of
Occup Health & Toxicol, Guangxi Med. University
Nanning, China and 3School of Health Sciences,
Purdue University, West Lafayette, IN.
MONDAY
BRAIN MAGNETIC RESONANCE IMAGING
AND BLOOD LEVELS OF TRACE
ELEMENTS AMONG MANGANESEEXPOSED STEEL WORKERS. X. Mo1, Y. Jiang2,
L. Long3, W. Zhao1, X. Li3, S. Su4 and W. Zheng5.
1
Department Neurol, Guangxi Med. University
Nanning, China, 2Department Occ Health &
Toxicol, Guangxi Med. University Nanning, China,
3
Department Radiology, Guangxi Med. University
Nanning, China, 4Guangxi Worker’s Hospital,
Nanning, China and 5Purdue University, West
Lafayette, IN.
#192
TOXICOGENOMICS AND BIOMARKER
DISCOVERY FOR THE PREDICTION OF
LONG TERM TOXICITY. H. Gmuender1, C.
Pallez1 and A. Hohn1. 1Genedata, Basel, Switzerland,
2
Genedata, Basel, Switzerland and 3Genedata, Basel,
Switzerland. Sponsor: H. Ahr.
#193
HEMOGLOBIN ADDUCT AS EXPOSURE
MARKERS OF CHEMICAL SUBSTANCES.
M. Ogawa, T. Oyama, T. Isse, T. Murakami,
T. Yamaguchi, T. Kinaga and T. Kawamoto.
Department of Environmental Health, University
of Occupational and Environmental Health, Japan,
Kitakyushu, Japan.
74
#194
VARIATION IN BIOLOGICAL RESPONSES
TO PEROXISOME PROLIFERATORS
BETWEEN MOUSE STRAINS. C. G. Woods1, A.
M. Burns1, A. Maki1, B. Universtiy of. Bradford1, D.
W. Threadgill1, M. L. Cunningham2 and I. Rusyn1.
1
University of North Carolina - Chapel Hill, Chapel
Hill, NC and 2Nat’l Cntr. for Toxicogenomics
and Nat’l Toxicology Program, NIEHS, Research
Triangle Park, NC.
#195
THE DEVELOPMENT OF AN IN VITRO
ASSAY FOR EVALUATING THE BINDING OF
PERFLUOROALKYL ACIDS (PFAAS) TO THE
PEROXISOME PROLIFERATOR-ACTIVATED
RECEPTORS (PPARS). M. L. Takacs and B. D.
Abbott. U.S. EPA, NHEERL, Research Triangle
Park, NC.
#196
NEW TRICKS FROM AN OLD DOG:
ACTIVATION OF PEROXISOME
PROLIFERATOR-ACTIVATED RECEPTORβ/δ
(PPARβ/δ) BY 4-HYDROXYNONENAL. J. D.
Coleman, S. K. Prabhu, J. T. Thompson and J. P.
Vanden Heuvel. Veterinary and Biomedical Sciences,
Pennsylvania State University, State College, PA.
#197
RECEPTOR α IS REGULATED BY GSK3. K. A.
Burns and J. P. Vanden Heuvel. Center for Molecular
Toxicology and Carcinogenesis, The Pennsylvania
State University, University Park, PA.
#198
CHARACTERIZATION OF PPARINDUCED MYOPATHY IN DIABETIC AND
NONDIABETIC RATS. B. Faiola1, D. Hoivik1,
B. Romach1, R. Peterson1, B. Berridge1, H. Jordan1,
M. Keener1, C. Poole2, T. Borts1, W. Casey1 and R.
Miller1. 1Safety Assessment, GlaxoSmithKline,
Research Triangle Park, NC and 2Drug Metabolism
and Pharmacokinetics, GlaxoSmithKline, Research
Triangle Park, NC.
#199
A COMPARATIVE ANALYSIS OF PPAR
AGONISTS IN RODENT AND CANINE
HEPATOCYTES: AN INVESTIGATION INTO
SPECIES SPECIFIC RESPONSES. Y. Guo, R.
Jolly, J. Stutz, M. Huffman, G. Searfoss, H. Gao, A.
Irizarry, T. Baker, J. Stevens and T. Ryan. Eli Lilly &
company, Greenfield, IN. Sponsor: C. Thomas.
45th Annual
Meeting & ToxExpo
DIFFERENTIAL GENE EXPRESSION
IN LIVER ASSOCIATED WITH THE
HEPATOPROTECTIVE EFFECT OF
PEROXISOME PROLIFERATORS. J. S. Moffit1,
P. H. Koza-Taylor2, R. D. Holland3, R. D. Beger3,
M. P. Lawton2 and J. E. Manautou1. 1Department of
Pharmacology Sciences., University of Connecticut,
Storrs, CT, 2Groton Laboratories, Molecular and
Investigative Toxicology, Pfizer, Inc., Groton, CT
and 3Division of Chemistry, National Center for
Toxicological Research, Jefferson, AR.
#201
MICE WITH PPARα KNOCKDOWN BY
siRNA ARE TRANSCRIPTIONALLY AND
PHENOTYPICALLY COMPARABLE TO
PPARα KNOCKOUT MICE. A. T. De Souza1,
X. Dai1, A. G. Spencer2, T. Reppen2, A. Menzie2, P.
L. Roesch2, Y. He1, M. J. Caguyong1, S. Bloomer1,
H. Herweijer2, J. A. Wolff2, J. E. Hagstrom2, D. L.
Lewis2, P. S. Linsley1 and R. G. Ulrich1. 1Rosetta
Inpharmatics, Merck & Co. Inc., Seattle, WA and
2
Mirus Bio Corporation, Madison, WI.
#202
MECHANISTIC INVESTIGATIONS ON
MOUSE SPECIFIC TOXICITY WITH A
PPARα/γ CO-AGONIST. F. Boess, L. Suter, E.
A. Atzpodien, G. Hoffmann and M. Bopst. NonClinical Development, F. Hoffmann - La Roche Ltd.,
Basel, Switzerland.
#204
IDENTIFICATION OF AUTOANTIBODIES
TO ALDOLASE B IN SERA FROM PATIENTS
WITH TROGLITAZONE-INDUCED LIVER
DYSFUNCTION. T. Yokoi1, R. Maniratanachote1,
A. Shibata1, S. Kaneko2, I. Yamamori3, T. Wakasugi4,
T. Sawazaki5, K. Katoh6, S. Tokudome7 and M.
Nakajima1. 1Drug Metabolism and Toxicology,
Faculty of Pharmaceutical Sciences, Kanazawa
University, Kanazawa, Japan, 2Graduate School of
Medicine, Kanazawa University, Kanazawa, Japan,
3
Nagoya First Red-Cross Hospital, Nagoya, Japan,
4
Fukui Prefectural Hospital, Fukui, Japan, 5Hitachi
Chemical Co. Ltd., Hitachi, Japan, 6Institute of
Developmental Research, Aichi Human Service
Center, Aichi, Japan and 7Dokkyo University School
of Medicine, Tochigi, Japan. Sponsor: T. Yoshida.
#205
#207
PPARβ MODULATION OF GENE
EXPRESSION IN A DIETARY MODEL OF
NONALCOHOLIC STEATOHEPATITIS. M. A.
Peraza, M. J. Kennett and J. M. Peters. Department
of Veterinary and Biomedical Sciences, Center for
Molecular Toxicology and Carcinogenesis, The
Pennsylvania State University, University Park, PA.
POSTER SESSION: AH RECEPTOR I
Chairperson(s): Sakina Eltom, Meharry Medical College, Nashville, TN
and Rushang Patel, Penn State University, University Park, PA.
DIFFERENTIAL GENE EXPRESSION IN
PRIMARY HEPATOCYTES EXPOSED TO
THE PEROXISOME PROLIFERATORS
ACTIVATED RECEPTOR-α AGONISTS. L.
Guo1, H. Fang1, S. Dial1, E. Blann1, J. Collins2 and Y.
Dragan1. 1Division of Systems Toxicology, National
Center for Toxicological Research, Food and
Drug Administration, Jefferson, AR and 2Agilent
Technologies, Inc., Palo Alto, CA.
MICROARRAY ANALYSIS OF CLOFIBRIC
ACID-EXPOSED HUMAN AND RAT
PRIMARY CULTURED HEPATOCYTES
AND CLOFIBRATE-TREATED RAT LIVER;
EXTRAPOLATION OF CLOFIBRATEINDUCED RNA EXPRESSION TO HUMAN?
S. Ogata1, Y. Suzuki1, T. Kitazima1, K. Ito1, N.
Kiyosawa1, K. Watanabe1, N. Niino1, M. Kanbori1, T.
Yamoto1, S. Manabe1, T. Fischer2, J. Mueller2 and M.
Teranishi1. 1Medicinal Safety Research Laboratories,
Sankyo Co., Ltd., Fukuroi, Shizuoka, Japan and
2
Drug Metabolism Department, Sankyo Pharma
GmbH, Munich, Germany.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
INDUCTION OF HEPATIC TRANSPORTERS
MRP3 AND MRP4 BY CLOFIBRATE IS
REGULATED BY PPARα J. E. Manautou1, J.
S. Moffit1, L. M. Aleksunes1, J. M. Maher2, G. L.
Scheffer3 and C. D. Klaassen2. 1Department of
Storrs, CT, 2Department of Pharmacology,
Toxicology, and Therapeutics, University of Kansas
Medical Center, Kansas City, KS and 3Department
of Pathology, VU Medical Center, Amsterdam,
Netherlands.
#203
#206
75
#208
β-NAPHTHOFLAVONE INDUCES
TRANSCRIPTION OF CONSTITUTIVE
ANDROSTANE RECEPTOR IN C57BL6/J
MICE. R. D. Patel, B. D. Hollingshead and G.
H. Perdew. Center for Molecular Toxicology and
Carcinogenesis, The Pennsylvania State University,
University Park, PA.
#209
MECHANISMS OF INHIBITORY ARYL
HYDROCARBON RECEPTOR-ESTROGEN
RECEPTOR A/SP1 CROSSTALK IN BREAST
CANCER CELLS. S. Liu1, S. Khan2, R.
Barhoumi3, R. Burghardt3, K. Kim2 and S. Safe1,
2 1
. Institute of Biosciences and Technology, Texas
A&M University Health Science Center, Houston,
TX, 2Department of Veterinary Physiology &
Pharmacology, Texas A&M University, College
Station, TX and 3Department of Veterinary
Integrated Biology, Texas A&M University, College
Station, TX.
#210
THE EFFECT OF CIGARETTE SMOKE
CONSTITUENTS ON AHR SIGNALING AND
SENESCENCE IN NORMAL HUMAN ORAL
KERATINOCYTES. L. Zhang1, J. Valentino2, R.
Dingle1, P. Xu1, D. Vongrises2 and H. I. Swanson1.
1
Molecular and Biomedical Pharmacology,
University of Kentucky, Lexington, KY and
2
Surgery, University of Kentucky, Lexington, KY.
#211
RELEVANCE OF THE AHR GENE BATTERY
FOR THE METABOLISM OF FRAGRANCES.
B. Bloemeke, M. Kalmes and S. Hahn-Quintes.
Ecotoxicology, University Trier, Trier, Germany.
MONDAY
#200
45th Annual
Meeting & ToxExpo
#212
APPLICATION OF FUNCTIONAL TOXICITY
ASSAYS TO COMPARE THE EFFECTS OF
TCDD WITH A POTENTIAL ENDOGENOUS
ARYL HYDROCARBON RECEPTOR
LIGAND. J. C. Bemis, E. C. Henry and T. A.
Gasiewicz. Environmental Medicine, University of
Rochester, Rochester, NY.
#213
AN IMAGING-BASED ASSAY
FOR ACTIVATION OF THE ARYL
HYDROCARBON RECEPTOR: A
MECHANISM-DEPENDENT, HIGH
THROUGHPUT TOXICITY ASSAY FOR DRUG
DISCOVERY. H. J. Garside1, 2, N. M. Brown1,
M. Graham2, M. Sullivan1 and E. Cooke1. 1ASTL,
AstraZeneca, Loughborough, United Kingdom and
2
Safery Assessment, AstraZeneca, Loughborough,
United Kingdom.
#214
MONDAY
#215
ANALYSIS OF AH RECEPTOR PROTEIN
CONCENTRATION IN LIVER AND LUNG
OF C57BL/6 MICE EXPOSED TO A SINGLE
ORAL DOSE OF TCDD. S. Dahlin1, D. R.
Boverhof2, T. Zacharewski2 and R. S. Pollenz1.
1
Biology, University of South Florida, Tampa, FL
and 2Biochemistry and Molecular Biology, Michigan
State University, East Lansing, MI.
THE C-JUN N-TERMINAL KINASE (JNK)DEPENDENT TCDD TOXICITY IN THYMUS.
Z. Tan, X. Chang, A. Puga and Y. Xia. Center
for Environmental Genetics and Department of
Environmental Health, University of Cincinnati
Medical Center, Cincinnati, OH.
#216
CALPAIN MEDIATES THE DIOXIN-INDUCED
ACTIVATION AND DOWN-REGULATION OF
THE ARYL HYDROCARBON RECEPTOR. Y.
R. Dale. Pharmacology, Meharry Medical College,
Nashville, TN.
#217
SINGLE CELL ANALYSIS OF SWITCH-LIKE
INDUCTION OF CYP1A1 BY HALOGENATED
HYDROCARBONS IN RAT HEPATOMA
CELLS. R. Billings and W. H. Hanneman.
Environmental Health, Colorado State University,
Fort Collins, CO.
#218
THE ARYL HYDROCARBON RECEPTOR
REGULATES CELL CYCLE PROGRESSION
IN THE ABSENCE OF XENOBIOTIC
LIGANDS. X. Chang, L. Peng and A. Puga.
Cincinnati, OH.
#219
CHIP-ON-CHIP MICROARRAY ANALYSIS
OF AHR PROMOTER BINDING SITES IN
HEPA-1C1C7 CELLS. J. L. Marlowe and A. Puga.
Cincinnati, OH.
#220
ENHANCEMENT OF DIOXIN-MEDIATED
CYP1A1 INDUCTION BY THE UBIQUITIN
LIGASE INHIBITOR 05RB. A. A. Elliott1, L.
Padmavathi2, A. Banerjee2 and J. Reiners Jr.1.
1
Institute of Environmental Health Sciences, Wayne
State University, Detroit, MI and 2Department of
Pharmaceutical Sciences, Wayne State University,
Detroit, MI.
76
#221
COMPARISON OF IN VITRO AND IN VIVO
GENE EXPRESSION RESPONSES MEDIATED
BY TCDD. E. Dere1, 2, D. R. Boverhof1, 2, 3, L. D.
Burgoon1, 2, 3 and T. R. Zacharewski1, 2, 3. 1Department
of Biochemistry and Molecular Biology, Michigan
State University, East Lansing, MI, 2National
Food Safety & Toxicology Center, Michigan State
University, East Lansing, MI and 3Center for
East Lansing, MI.
#222
AHR SIGNALING AND GENE EXPRESSION
CHANGES DURING REGENERATIVE
GROWTH. L. K. Mathew1, 2, 3, E. A. Andreasen1,
2, 3
and R. L. Tanguay1, 2, 3. 1Environmental and
Corvallis, OR, 2The Environmental Health Sciences
Center, Oregon State University, Corvallis, OR and
3
The Marine and Freshwater Biomedical Sciences
Center, Oregon State University, Corvallis, OR.
#223
EFFECTS OF TCDD ON GLOBAL GENE
EXPRESSION IN REGENERATING TISSUE.
E. A. Andreasen1, 2, 3, L. K. Mathew1, 2, 3 and R. L.
Tanguay1, 2, 3. 1Department of Environmental and
Corvallis, OR, 2The Environmental Health Sciences
3
The Marine and Freshwater Biomedical Sciences
Center, Oregon State University, Corvallis, OR.
#224
THE INFLUENCE OF A HISTONE
DEACETYLASE INHIBITOR ON THE GENE
EXPRESSION PROFILES INDUCED BY
AROCLOR 1254 AND TCB. S. Reymann1 and
J. Borlak1. 1Fraunhofer Institut of Toxicology and
Experimental Medicine, Hannover, Germany
and 2Fraunhofer Institute of Toxicology and
Experimental Medicine, Hannover, Germany.
#225
COMBINATORIAL GENE REGULATION
BY THE ESTROGEN AND ARYL
HYDROCARBON RECEPTORS. C. Bobowski
and E. V. Hestermann. Biology Department, Furman
University, Greenville, SC.
#226
THE ROLE OF NITRIC OXIDE IN
THE DOWN-REGULATION OF ARYL
HYDROCARBON RECEPTOR-REGULATED
GENES BY INFLAMMATION. N. Gharavi
and A. O. El-Kadi. Faculty of Pharmacy and
Pharmaceutical Sciences, University of Alberta,
Edmonton, AB, Canada.
#227
DIOXIN INDUCES AN ESTROGEN
RECEPTOR DEPENDENT ESTROGEN-LIKE
GENE EXPRESSION RESPONSE IN THE
MURINE UTERUS. D. R. Boverhof, J. C. Kwekel,
D. G. Humes, L. D. Burgoon and T. R. Zacharewski.
Department of Biochemistry & Molecular Biology,
National Food Safety & Toxicology Center, and
45th Annual
Meeting & ToxExpo
#228
TCDD-INDUCED DIFFERENTIAL
COACTIVATOR RECRUITMENT TO CYP1A1
AND CYP1B1. R. T. Taylor1, F. Wang2, R. Zhang2
and O. Hankinson2, 1. 1Molecular Toxicology IDP,
University of California, Los Angeles, Los Angeles,
CA and 2Department of Pathology and Laboratory
Medicine, Molecular Biology Institute, and Jonsson
Comprehensive Cancer Center, David Geffen School
of Medicine, University of California, Los Angeles,
Los Angeles, CA.
#234
GCLM-NULL AND WILD-TYPE MICE
EXPOSED TO DIESEL EXHAUST. E. C. Peck,
L. A. McConnachie, R. P. Beyer, T. K. Bammler,
C. Baker, D. Ceballos, P. A. Vliet, J. A. Stewart,
D. L. Luchtel, J. D. Kaufman and T. J. Kavanagh.
Environmental and Occupational Health Sciences,
#235
VALIDATION OF THE PRO-INFLAMMATORY
EFFECTS OF A DIESEL PM EXTRACT IN
BEAS-2B CELLS AFTER AN EXPERIMENTAL
SOLVENT EXCHANGE METHOD. K. J.
Swanson1, M. C. Madden2, 1 and A. J. Ghio2.
1
Environmental Sciences & Engineering, University
of North Carolina - Chapel Hill, Chapel Hill, NC
and 2HSD, NHEERL, U.S. EPA, Chapel Hill, NC.
#236
ROLE OF TOLL LIKE RECEPTORS ON
PULMONARY INFLAMMATORY RESPONSES
TO SIZE FRACTIONATED COMBUSTION
AND AMBIENT AIR PARTICLES. I. Gilmour,
M. Daniels, E. Boykin, W. Linak and R. Devlin. U.S.
#237
EFFECTS OF PM2.5 COLLECTED FROM
CACHE VALLEY UTAH IN HUMAN
BRONCHIAL EPITHELIAL CELLS. T. L.
Watterson1, J. Sorenson1, R. S. Martin2 and R. A.
Coulombe1. 1Graduate Toxicology Program and
Department of Veterinary Sciences, Utah State
University, Logan, UT and 2Department of Civil and
Environmental Engineering, Utah State University,
Logan, UT.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: RESPONSES TO PARTICULATES
Chairperson(s): Steve Gavett, U.S. EPA, Research Triangle Park, NC and
John Veranth, University of Utah, Salt Lake City, UT.
#229
ACIDIC EXTRACTS OF WOOD SMOKE
PARTICULATE MATTER CAUSE CASPASE
INDEPENDENT APOPTOSIS IN MOUSE RAW
AND MLE CELLS. K. A. Fay, C. D. Simpson,
R. L. Dills, M. H. Paulsen and T. J. Kavanagh.
Environmental and Occupational Health, University
of WA, Seattle, WA.
#230
COMPARISON OF CIGARETTE SMOKE
TOXICITY WITH VARIOUS INHALATION
EXPOSURE REGIMENS. H. Yoshimura1, K.
Yoshino1, G. Lulham2, K. M. Lee3 and R. A. Renne3.
1
Japan Tobacco, Tokyo, Japan, 2JTI-Macdonald
Corp., Toronto, ON, Canada and 3Battelle
Toxicology Northwest, Richland, WA.
#238
CARBON MONOXIDE AND NITROGEN
OXIDES ANALYSIS IN MAINSTREAM
SMOKE OF POTENTIALLY REDUCED
EXPOSURE PRODUCTS(PREPS - QUEST1),
MARLBORO MEDIUM, AND 2R4F
CIGARETTES UNDER DIFFERENT PUFFING
REGIMENS. N. Gowadia1, M. Oldham1 and D.
Dunn-Rankin2. 1Community and Environmental
Medicine, University of California, Irvine, Irvine,
CA and 2Mechanical and Aerospace Engineering,
University of California, Irvine, Irvine, CA.
INFLAMMATION AND TISSUE DAMAGE
IN THE MOUSE LUNG CAUSED BY SIZE
SEGREGATED PARTICULATE SAMPLES
COLLECTED IN DIFFERENT SEASONS IN
HELSINKI. M. S. Happo1, 2, R. O. Salonen1, A. I.
Halinen1, P. Jalava1, 2 and M. Hirvonen1. 1Department
of Environmental Health, National Public Health
Institute, Kuopio, Finland and 2University of
Kuopio, Kuopio, Finland. Sponsor: M. Viluksela.
#239
CYTOTOXIC AND INFLAMMATORY
RESPONSES TO WATERSOLUBLE AND
INSOLUBLE COMPONENTS OF SIZESEGREGATED URBAN AIR PARTICULATE
MATTER IN VITRO. P. Jalava1, 2, R. O. Salonen1,
A. I. Halinen1, M. Happo1, 2, A. S. Pennanen1,
M. Sillanpaa3, R. Hillamo3 and M. Hirvonen1.
1
Department of Environmental Health, National
Public Health Institute (KTL), Kuopio, Finland,
2
University of Kuopio, Kuopio, Finland and 3Finnish
Meteorological Institute, Helsinki, Finland. Sponsor:
M. Viluksela.
#240
PULMONARY AND SYSTEMIC EFFECTS
OF INHALED COAL FLY ASH PARTICLES
IN RATS. K. R. Smith1, J. M. Veranth2, Universtiy
of. P. Kodavanti3, M. C. Schladweiler3, I. Espiritu1,
J. J. Recendez1, A. E. Aust4 and K. E. Pinkerton1.
1
Center for Health and the Environment, University
of California, Davis, CA, 2Pharmacology and
Toxicology, University of Utah, Salt Lake City, UT,
3
NHEERL, U.S. EPA, Research Triangle Park, NC
and 4Department of Chemistry and Biochemistry,
Utah State University, Logan, UT.
#231
#232
#233
REAL TIME RT-PCR ASSESSMENT
OF CLEARANCE OF RESPIRATORY
SYNCYTIAL VIRUS ALTERED BY
EXPOSURE TO DIESEL EXHAUST AND
HARDWOOD SMOKE. M. D. Reed and J. A.
Berger. Toxicology, Lovelace Respiratory Research
Institute, Albuquerque, NM.
NEUROTROPHINS OPERATE AT DIFFERENT
LEVELS OF THE RESPIRATORY TRACT
IN RESPONSES OF ALLERGIC MICE
TO DIESEL EXHAUST PARTICLES
(DEPARTMENT). S. H. Gavett, A. K. Farraj, N.
Haykal-Coates, A. D. Ledbetter and P. A. Evansky.
NHEERL U.S. EPA, Research Triangle Park, NC.
77
MONDAY
45th Annual
Meeting & ToxExpo
#241
CHARACTERIZATION OF COARSE
(PM10-PM2.5) AND FINE (<PM2.5)
RESUSPENDED ROADWAY DUST IN THE
NORTHEAST, SOUTHEAST, SOUTHWEST
AND WESTERN Universtiy of.S. J. McDonald, J.
Seagrave and J. L. Mauderly. Toxicology, Lovelace
Respiratory Research Institute, Albuquerque, NM.
#242
PARTICULATE MATTER INTERFERES
WITH COMMONLY USED IN VITRO ASSAYS
AND CONFOUNDS INTERPRETATION OF
EXPERIMENTAL RESULTS. J. M. Veranth, M.
Koch, N. Cutler, C. A. Reilly, M. M. Veranth and G.
S. Yost. Pharmacology and Toxicology, University of
Utah, Salt Lake City, UT.
#243
#244
DEVELOPMENT OF ALTERNATIVE IN
VITRO METHODS TO ASSESS PULMONARY
TOXICITY OF INHALED FINE AND NANOSIZED PARTICLES. D. B. Warheit, T. R. Webb and
K. L. Reed. DuPont Haskell Laboratory for Health
and Environmental Sciences, Newark, DE.
MONDAY
THE IMPORTANCE OF DAILY SAMPLING
IN CONCENTRATED AMBIENT PARTICLES
AND CELLULAR RESPONSE STUDY. E. Baja,
X. Jin and L. Chen. Environmental Medicine, NYU
School of Medicine, Tuxedo, NY.
#247
TOXICOLOGIC INVESTIGATIONS OF 1FURAN-2-YL-3-PYRIDIN-2-YL-PROPENONE
IN FEMALE BALB/C MICE: SUBACUTE
IMMUNOTOXICITY. T. Jeon1, S. Lee1, C. Jin1,
G. Kim1, I. Jun1, D. Lee1, A. Basnet1, H. Jeong2, E.
Lee1 and T. Jeong1. 1College of Pharmacy, Yeungnam
University, Gyeongsan, South Korea and 2College
of Pharmacy, Chosun University, Gwangju, South
Korea.
#248
E. COLI HEAT-LABILE ENTEROTOXIN BSUBUNIT (HF1020) IS A POTENT IMMUNE
MODULATOR CAPABLE OF INHIBITING
AIRWAY INFLAMMATION IN A MURINE
MODEL OF ASTHMA. N. A. Williams1, H. K.
Bone1 and J. Murphy2. 1KWS BioTest, Bristol,
United Kingdom and 2Hunter Fleming Limited,
Bristol, United Kingdom. Sponsor: R. Harling.
#249
EFFECT OF DIESEL EXHAUST EXPOSURE
ON MUCOSAL SENSITIZATION TO
OVALBUMIN ANTIGEN. T. Stevens2, M. Daniels1,
E. Boykin1, W. Linak1 and I. Gilmour1. 1U.S. EPA,
Research Triangle Park, NC and 2Curriculum in
Toxicology, University of North Carolina - Chapel
Hill, Chapel Hill, NC.
#250
PROINFLAMMATORY EFFECTS OF
2’METHOXYETHYL (MOE) NON-CPG
ANTISENSE OLIGONUCLEOTIDES (ASO) IN
THE RAT. L. J. Shen, K. Kramer-Stickland, R. Fey,
E. Hatcher, G. Hung, S. P. Henry and A. A. Levin.
ISIS Pharmaceuticals, Inc., Carlsbad, CA.
#251
DRUG-INDUCED THROBOCYTOPENIA IN
BEAGLE DOGS: A CASE STUDY. W. Olivier, G.
Francoise, B. Anne, B. Helene, V. Guy and C. Nancy.
Drug Safety Assessment, Servier, Orleans, France.
#252
EFFECT OF NATALIZUMAB ON PRIMARY
AND SECONDARY HUMORAL RESPONSES
IN CYNOMOLGUS MONKEYS. C. Hurst1,
S. Parker1, V. Palmer1, N. Wehner2 and J. Clarke1.
1
Biogen Idec, Cambridge, MA and 2Elan, South San
Francisco, CA.
#253
EFFECT OF ABATACEPT ON THE
DEVELOPING IMMUNE SYSTEM IN
A STUDY OF PRE- AND POSTNATAL
DEVELOPMENT IN RATS. H. G. Haggerty1, L.
Iciek1, 4, J. Jones1, M. A. Abbott1, D. G. Gonchoroff1,
L. Phelps1, D. DeVona1, T. Bigwarfe1, R. W. Diters1,
R. Weiner2, H. Dong2, R. York3, N. Catricks3, T. J.
Davidson1 and E. Lochry2. 1Immunotoxicology,
Bristol-Myers Squibb, East Syracuse, NY, 2Drug
Safety Evaluation, Bristol-Myers Squibb, New
Brunswick, NJ, 3Charles River Laboratories,
Horsham, PA and 4Currently Global Preclinical
Safety, Abbott Laboratories, Abbott Park, IL.
#254
THE EFFECT OF MMA-SS WELDING FUMES
ON THE HUMORAL IMMUNE RESPONSE IN
B6C3F1 MICE. S. E. Anderson, B. J. Meade and A.
E. Munson. NIOSH, Morgantown, WV.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: IMMUNOMODULATION
Chairperson(s): Paige Lawrence, Washington State Univerisity, Pullman,
WA and Scott Burchiel, University of New Mexico, Albuquerque, NM.
#245
#246
ROLE OF IMMUNOMODULATION BY
THE SELECTIVE COSTIMULATION
MODULATOR, ABATACEPT, IN MOUSE
MAMMARY TUMOR VIRUS (MMTV)INITIATED TUMORS. T. P. Reilly1, M. Abbott1,
T. Golovkina2, J. Proctor1, L. Case2, C. Comereski1,
H. Fang1, S. Wells1, W. Freebern1, J. D. Frantz1, S.
K. Durham1 and H. G. Haggerty1. 1Drug Safety
Evaluation, Bristol-Myers Squibb, Syracuse, NY
and 2The Jackson Laboratory, Bar Harbor, ME.
ENHANCEMENT OF INNATE IMMUNE
RESPONSES AND OXIDATIVE EVENTS
AFTER EXPOSURE TO PARTICULATE
MATTER PRESENT IN URBAN AIR
POLLUTION. A. Campbell, L. B. Mendez, A.
Becaria, H. Li and M. Kleinman. Comm. & Env.
Medicine, University of CA, Irvine, Irvine, CA.
78
45th Annual
Meeting & ToxExpo
#255
EVALUATION OF PERFLUOROOCTANOIC
ACID IMMUNOTOXICITY IN ADULT MICE.
B. Luebke1, C. B. Copeland1 and J. C. DeWitt2.
1
Immunotoxicology Branch, U.S. EPA, ORD,
NHEERL, ETD, Research Triangle Park, NC and
2
Curriculum in Toxicology, University of North
Carolina, Chapel Hill, NC.
#256
ORAL EXPOSURE TO PERFLUOROOCTANE
SULFONATE (PFOS) FOR 28 DAYS
SUPPRESSES IMMUNOLOGICAL
FUNCTION IN B6C3F1 MICE. M. PedenAdams1, J. Stuckey2, J. EuDaly1 and D. Keil3.
1
MUSC, Charleston, SC, 2College of Charleston,
Charleston, SC and 3UNLV, Las Vegas, NV.
#257
AHR ACTIVATION PROTECTS MICE
FROM LETHAL CHALLENGE WITH
STREPTOCOCCUS PNEUMONIAE, BUT THE
IMPROVED SURVIVAL DOES NOT RESULT
FROM AN ENHANCED INFLAMMATORY
RESPONSE. B. A. Vorderstrasse and B. Lawrence.
Pharmaceutical Sciences, Washington State
University, Pullman, WA.
#258
DEFINING THE CONTRIBUTION OF ARYL
HYDROCARBON RECEPTOR (AHR)MEDIATED DEFECTS IN DENDRITIC CELL
AND T CELL FUNCTION RESULTING IN A
DIMINISHED CYTOTOXIC T LYMPHOCYTE
(CTL) RESPONSE. J. J. Neumiller1, 2, J. A. Cundiff1
and B. Lawrence1. 1Pharmaceutical Sciences,
Washington State University, Pullman, WA and
2
NIH Post-Doctoral Immunology Training Program,
Pullman, WA.
#259
REDUCED PARASITE BURDENS ARE NOT
CORRELATED WITH ELEVATED TNF
LEVELS IN LEISHMANIA MAJOR-INFECTED
TCDD-TREATED MICE. K. Sommersted and G.
DeKrey. School of Biological Sciences, University
of Northern Colorado, Greeley, CO.
#260
INVESTIGATING THE ROLE OF THE
NEUROIMMUNE AXIS IN PCB-INDUCED
IMMUNOTOXICITY USING A FISH
MODEL. J. Duffy and J. T. Zelikoff. Department
of Environmental Medicine, New York University
#261
#262
T-2 TOXIN DIMINISHES HOST RESISTANCE
TO RESPIRATORY REOVIRUS INFECTION.
M. Li1, 2, 3, J. R. Harkema3, Z. Islam1, 2, 3, C. F. Cuff4
and J. Pestka1, 2, 3. 1Department of Microbiology and
Molecular Denetics, Michigan State University,
East Laning, MI, 2Food Science and Human
Nutrition, Michigan State University, East Laning,
MI, 3Pathobiology and Diagnostic Investigation,
Michigan State University, East Laning, MI and
4
Department of Microbilogy and Immunology, West
Virginia University, Morgantown, WV.
AN ANIMAL MODEL FOR DETRIMENTAL
AND BENEFICIAL EFFECTS OF ETHANOL
WITH REGARD TO THE ACUTE PHASE
RESPONSE. B. S. Pruett and S. B. Pruett. Cellular
BIology & Anatomy, LSU Health Sciences Center,
Shreveport, LA.
79
#263
DUAL, INDEPENDENT MECHANISMS
OF ACTION OF ETHANOL IN THE
MODULATION OF CYTOKINE
PRODUCTION. M. Glover, Q. Zheng, R. Fan and
S. B. Pruett. Cellular BIology & Anatomy, LSU
Health Sciences Center, Shreveport, LA.
#264
THE ROLE OF P450 CYP1B1 AND EPHX1 IN
7, 12-DIMETHYLBENZ(A)-ANTHRACENE
AND BENZO(A)PYRENE INDUCED
IMMUNOTOXICITY IN C57BL/6N MICE. S. W.
Burchiel, J. Gao, L. Mitchell and F. T. Lauer. College
of Pharmacy Toxicology Program, The University of
New Mexico, Albuquerque, NM.
#265
METALLOTHIONEIN GENE DOSE EFFECTS
CADMIUM EFFECTS ON IMMUNE
CAPACITY. M. Lynes, X. Yin, D. Unfricht, G.
Jin and K. Zaffuto. Molecular and Cell Biology,
University of Connecticut, Storrs, CT.
#266
CB1/CB2 DEPENDENT AND INDEPENDENT
IMMUNE MODULATION BY ∆9TETRAHYDROCANNABINOL. A. E. Springs
and N. E. Kaminski. Department of Pharmacology
and Toxicology and the Center for Integrative
Toxicology, Michigan State University, East
Lansing, MI.
#267
DEVELOPMENT OF TOLERANCE TO
THE IMMUNOSUPPRESSIVE EFFECTS
OF ∆9-TETRAHYDROCANNABINOL (THC)
IN B6C3F1 MICE. C. M. Sheth and K. L.
White. Pharmacology and Toxicology, Virginia
Commonwealth University, Richmond, VA.
#268
ENHANCED CYTOTOXIC T CELL ACTIVITY
FOLLOWING EXPOSURE TO COMMERCIAL
ECHINACEA PURPUREA. K. L. White1, D.
R. Germolec2, W. Auttachoat1, R. Brown1, D. L.
Musgrove1 and T. L. Guo1. 1Pharmacology and
Toxicology, Virginia Commonwealth Univeristy,
Richmond, VA and 2NIEHS, Research Triangle Park,
NC.
#269
SUNSCREENS PREVENT ULTRAVIOLET
RADIATION-INDUCED IMMUNE
SUPPRESSION OF CONTACT
HYPERSENSITIVITY IN HAIRLESS MICE.
H. Kim, J. Lee, J. Sin, J. Gil, J. Kim, J. Kim, Y. Jo
and K. Park. Immunotoxicology, National Institute
of Toxicological Research, Seoul, South Korea.
Sponsor: Y. Heo.
#270
PERSISTENT SUPPRESSION OF THE
PRIMARY HUMORAL IMMUNE RESPONSE
TO SHEEP RED BLOOD CELLS IN
RATS POST-NATALLY EXPOSED TO
CYCLOSPORINE. G. Ravel1, J. Descotes2, F.
Horand1 and P. C. Barrow1. 1MDS Pharma Services,
St Germain s/L’Arbresle, France and 2Poison Center,
Lyon, France.
MONDAY
45th Annual
Meeting & ToxExpo
MONDAY
#271
HUMORAL RESPONSE TO KLH AND
LYMPHOCYTE SUBSET ANALYSIS
IN MONKEYS TREATED WITH
CYCLOSPORINE. F. Horand1, G. Ravel1, F.
Condevaux1 and J. Descotes2. 1MDS Pharma
Services, St Germain s/L’Arbresle, France and
2
Poison Center, Lyon, France.
#278
GENISTEIN MODULATION OF IGE
PRODUCTION BY ADULT B6C3F1 MICE
FOLLOWING IN UTERO EXPOSURE IS
AFFECTED BY SEX AND LITTER ORDER. T.
L. Guo, W. Auttachoat, D. M. Hernandez and R. P.
Chi. Virginia Commonwealth University, Richmond,
VA.
#272
IMMUNOMODULATORY EFFECTS OF
LOW-DOSE DIETARY DEOXYNIVALENOL
AND ACUTE EXERCISE STRESS IN BALB/C
MICE. C. A. Landgren1, M. Kohut2, J. Cunnick3 and
S. Hendrich1. 1Food Science and Human Nutrition,
Iowa State University, Ames, IA, 2Health and Human
Performance, Iowa State University, Ames, IA and
3
Animal Science, Iowa State University, Ames, IA.
#279
LEAD INHIBITS NITRIC OXIDE
PRODUCTION IN MYELOID SUPPRESSOR
CELLS RESULTING IN UNREGULATED T
CELL PROLIFERATION. D. G. Farrer and M.
J. McCabe. Environmental Medicine, University of
#280
DIMERCAPTO SUCCINIC ACID
(DMSA) TREATMENT INCREASE T
CD4 LYMPHOCYTES RESPONSE IN
LEAD POISONED CHILDREN. CASES
PRESENTATION. R. C. Goytia1, S. J. Duarte1,
R. Meza-Velazquez1, M. Rosales-Gonzalez1, M.
Rubio-Andrade1, G. Garcia-Arenas1, M. Guerrero
Almeida1, J. Candelas1, M. Hernandez-Serrano2,
A. Torres-Vega3, V. Lujan-Galvan3 and G. GarciaVargas1. 1Facultad de Medicina, Universidad Juarez
del Estado de Durango, Gómez Palacio, Durango,
Mexico, 2Centro de Investigaciones Biomedicas,
UAC, Torreon, Coahuila, Mexico and 3Secretaria de
Salud, Torreon, Coahuila, Mexico.
#281
EVALUATION OF THE EFFECTS OF
MANCOZEB EXPOSURE ON THE IMMUNE
SYSTEM OF AGRICULTURE WORKERS:
AN ITALIAN STUDY. E. Corsini1, S. Birindelli2,
C. Bosetti3, S. Fustinoni4, L. Campo4, M. Maroni2,
H. Van Loveren5, C. L. Galli1 and C. Colosio2.
1
Department Pharmacological Sciences, University
of Milan, Milan, Italy, 2ICPS, Hospital L. Sacco,
Milan, Italy, 3Mario Negri Institute, Milan, Italy,
4
Department of occupational and Environmental
Health, University of Milan, Milan, Italy and
5
RIVM, Bilthoven, Netherlands.
#282
IMMUNOMODULATORY EFFECTS OF
THE HERBICIDE PROPANIL ON HUMAN
CYTOKINE PRODUCTION: IN VIVO AND
IN VITRO STUDIES. C. L. Galli1, S. Birindelli2,
C. Minoia3, C. Colosio2, M. Marinovich1 and E.
Corsini1. 1Department Pharmacological Sciences,
University of Milan, Milan, Italy, 2ICPS, Hospital
L. Sacco, Milan, Italy and 3S. Maugeri Foundation,
Pavia, Italy.
#283
A POTENTIAL LINK BETWEEN PERINATAL
PESTICIDE EXPOSURE AND ADULT
MORTALITY IN RURAL AFRICA. R. M.
Gogal1, 3, O. N. Ofordile2, D. E. Jones3 and S. D.
Holladay3. 1Biomedical Sciences, EVVCOM, Va
Tech, Blacksburg, VA, 2Medical Research Council,
Keneba, Gambia and 3College of Veterinary
Medicine, VA Tech, Blacksburg, VA.
#273
DEOXYNIVALENOL INDUCES
IMMUNOSUPPRESSION VIA INDUCTION
OF APOPTOSIS AND CYTOKINES IN B6C3F1
MICE. J. Cho, S. Jeong, H. Ku, H. Kang and
H. Pyo. Toxicology Division, NVRQS, Anyang,
Kyunggi, South Korea.
#274
ALTERATIONS OF THE IMMUNE
SYSTEM DURING CRITICAL STAGES OF
DEVELOPMENT FOLLOWING EXPOSURE
TO 1, 2:5, 6 DIBENZANTHRACENE (DBA) IN
B6C3F1 MICE. D. M. Hernandez, W. Auttachoat,
T. L. Guo and K. L. White. Pharmacology and
Toxicology, Virginia Commonwealth University,
Richmond, VA.
#275
IMMUNOSUPPRESSIVE EFFECT ON
F1 GENERATION MICE FOLLOWING
GESTATIONAL EXPOSURE TO
TRICHOTHECENES MYCOTOXIN, T-2
TOXIN. Y. Sugita-Konishi1, C. Yashiro2, K.
Kobayashi-Hattori2, M. Tsunoda3 and T. Takita2.
1
Division of Microbiology, National Institute
of Health Sciences, Tokyo, Japan, 2Department
of Nutritional Sciences, Tokyo University of
Agriculture, Tokyo, Japan and 3Department of
Medicine, Kitasato University, Kanagawa, Japan.
#276
PRENATAL EXPOSURE TO CIGARETTE
SMOKE PRODUCES THYMIC ATROPHY
AND ALTERS T-LYMPHOCYTE-MEDIATED
TUMOR SURVEILLANCE MECHANISMS IN
THE OFFSPRING. J. T. Zelikoff, S. P. Ng and M.
C. Bosland. Environmental Medicine, New York
University School of Medicine, Tuxedo, NY.
#277
IDENTIFYING THE DEVELOPMENTAL
WINDOW IN WHICH AHR ACTIVATION
LEADS TO ALTERATIONS IN IMMUNE
FUNCTION LATER ON IN LIFE. J. P.
Hogaboam1, J. A. Cundiff2 and P. B. Lawrence2, 1.
1
School of Molecular Biosciences, Biotechnology
Training Program, Washington State University,
Pullman, WA and 2Department of Pharmaceutical
Sciences, Washington State University, Pullman,
WA.
80
45th Annual
Meeting & ToxExpo
#284
MERCURY EXPOSURE INCREASES
BIOMARKERS OF AUTOIMMUNE
DYSFUNCTION IN AN EXPOSED GOLD
MINING POPULATION COMPARED TO
OCCUPATIONAL REFERENCE GROUPS.
R. M. Gardner, J. Nyland and E. K. Silbergeld.
Environmental Health Sciences, Johns Hopkins
Bloomberg School of Public Health, Baltimore, MD.
#285
PROTECTION OF NON-OBESE DIABETIC
(NOD) MICE FROM AUTOIMMUNE
DIABETES BY ESCHERICHIA COLI
HEAT-LABILE ENTEROTOXIN B SUBUNIT
(HF1020). J. Murphy1, N. A. Williams2 and T. Ola2.
1
Hunter-Fleming Limited, Bristol, United Kingdom
and 2KWS BioTest, Bristol, United Kingdom.
Sponsor: R. Harling.
#286
ESCHERICHIA COLI HEAT-LABILE
ENTEROTOXIN B-SUBUNIT (HF1020)
PREVENTS AUTOIMMUNE ARTHRITIS
THROUGH THE INDUCTION OF
REGULATORY CD4+ T CELLS. J. Luross1, N. A.
Williams1 and J. Murphy2. 1KWS BioTest, Bristol,
United Kingdom and 2Hunter-Fleming Limited,
Bristol, United Kingdom. Sponsor: R. Harling.
#287
#288
IMMUNO- AND HEPATOTOXICITY OF
DICHOLOROACETIC ACID IN MRL +/+ AND
B6C3F1 MICE. P. Cai, B. S. Kaphalia and G.
Ansari. Pathology, UTMB, Galveston, TX.
#290
PATHOBIOLOGY OF A VALVULOPATHY
IN FISCHER 344 RATS GIVEN A
TRANSFORMING GROWTH FACTOR-β
RI KINASE INHIBITOR. A. J. Stauber, J. L.
Zimmermann and B. Berridge. Toxicology Division,
Eli Lilly and Company, Greenfield, IN.
#291
QUANTITATIVE MORPHOLOGIC
ASSESSMENT ON EXTRACELLULAR
MATRIX IN CHEMICAL-INDUCED
DEVELOPMENTAL DISSECTING AORTIC
ANEURYSM USING MULTIPHOTON
FLORESCENCE AND SECOND HARMONIC
GENERATION MICROSCOPY. B. gong1,
L. Wang1, 3, J. Sun2, G. Vargas2 and P. Boor1.
1
Cardiovascular Toxicology, Pathology, UTMB,
Galveston, TX, 2Center of Biomedical Engineering,
UTMB, Galveston, TX and 3Division of
Cardiovascular Medicine, Medical School of
University of Nanjing, Nanjing, Jiangsu, China.
#292
SCREENING OF RELATIVE TOXICITY AND
ACTIVITY OF SEVERAL CRP ANTISENSE
INHIBITORS IN CYNOMOLGUS MONKEYS.
S. Henry1, T. A. Zanardi1, M. J. Graham1, M.
Mazzone2, R. Early2, R. M. Crooke1 and A. A. Levin1.
1
ISIS Pharmaceuticals, Inc., Carlsbad, CA and
2
Charles River Laboratories, Sparks, NV.
#293
THE PREVENTION OF RESTENOSIS BY
SIROLIMUS:A PHARMACOGENOMICS
APPROACH. E. Koo1, R. Thyagarajan3, D.
Argentieri3, J. Siekerka3, R. Falotico3, D. Jack1,
Q. Liu1, C. Alveres1, S. Weyer1, P. Miller1, S.
Godin1 and T. Parry2. 1Toxicology, Gene Logic
Inc., Gaithersburg, MD, 2Johnson & Johnson
Pharmaceutical, Spring House, PA and 3Cordis
Corporation, Warren, NJ.
#294
USING GENE EXPRESSION PROFILING
AND MOLECULAR PATHWAY ANALYSIS TO
EXAMINE THE PATHOGENESIS OF DRUG
INDUCED VASCULAR INJURY IN CANINE
CORONARY ARTERIES. B. E. Enerson1, A. Lin1,
B. Lu2, L. F. Nelms2, P. Koza-Taylor2, H. Zhao1,
M. P. Lawton2, J. R. Bender1 and E. Floyd2. 1Yale
University, New Haven, CT and 2Safety Sciences,
Pfizer, Groton, CT.
#295
A PROINFLAMMATORY ROLE OF MAST
CELL DEGRANULATION (MCD) IN
DRUG-INDUCED VASCULAR INJURY IN
SPRAGUE-DAWLEY RATS. J. Zhang1, A.
Knapton1, T. J. Miller1, P. Espandiari1, R. Anderson1,
E. H. Herman1, R. Snyder2, J. Hanig1 and J. L.
Weaver1. 1CDER, USFDA, Silver Spring, MD and
2
Schering-Plough Research Institute, Lafayette, NJ.
#296
IN-SITU PERFUSION OF RAT MESENTERY
WITH DRUGS TO EVALUATE ROLE OF
MAST CELL DEGRANUALTION IN EARLY
MESENTERIC VASCULAR INFLAMMATION.
A. D. Knapton1, J. Zhang1, J. L. Weaver1, F. D.
Sistare2 and J. Hanig1. 1CDER, USFDA, Silver
Spring, MD and 2Merck, West Point, PA.
LIFETIME EXPOSURE TO
TRICHLOROETHYLENE (TCE) DOES NOT
ACCELERATE AUTOIMMUNE DISEASE IN
MRL +/+ MICE. D. Keil1, J. EuDaly2, J. Miller2, G.
Gilkeson2 and M. Peden-Adams2. 1UNLV, Las Vegas,
NV and 2MUSC, Charleston, SC.
Monday, March 6
9:30 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: CARDIOVASCULAR SYSTEM: VALVULAR
AND VASCULAR INJURY
Chairperson(s): Cheste Ni, Pfizer Global Research & Development, Ann
Arbor, MI and Kazim Husain, Ponce School of Medicine, Ponce, Puerto
Rico.
#289
EXPLORATION OF VALVULAR HEART
DISEASE IN NEONATAL RATS COADMINISTERED FENFLURAMINE AND
PHENTERMINE. T. K. Baker1, L. M. Munsie1, A.
V. Wilke3, J. L. Stevens1, J. L. Hanes4, K. B. Donnelly2
and M. A. Davis1. 1Investigative Toxicology, Eli Lilly
and Company, Greenfield, IN, 2Endocrine/Cancer
Pathology, Eli Lilly, Greenfield, IN, 3Cardiovascular
Safety Assessment, Eli Lilly, Greenfield, IN and
4
Animal Studies, Eli Lilly and Company, Greenfield,
IN.
81
MONDAY
45th Annual
Meeting & ToxExpo
#297
ACROLEIN MEDIATES PLATELET
ACTIVATION. S. E. D’Souza2, D. J. Conklin1,
A. Bhatnagar1 and S. Srivastava1. 1Cardiology,
University of Louisville, Louisville, KY and
2
Physiology & Biophysics, University of Louisville,
Louisville, KY.
#298
STRUCTURE-TOXICITY-RELATIONSHIP
MODELING FOR DRUG-ASSOCIATED
VASCULITIS IN HUMANS: POSITIVE
ASSOCIATION WITH A BENZENESULFONAMIDE MOTIF AND A POSSIBLE
LINK TO MYELOPEROXIDASE. C. T. Ni1, E.
Gifford1, J. Paulauskis2, S. Duddy2 and F. Clemo3.
1
Chemical Technologies, Pfizer, Ann Arbor, MI,
2
Safety Sciences, Pfizer, Ann Arbor, MI and 3Safety
Sciences, Pfizer, Groton, CT.
MONDAY
#299
PRIMING DOSE OF PHENYLHYDRAZINE
PROTECTS AGAINST LETHAL EFFECTS
OF BUTOXYETHANOL. H. M. Mehendale, P. S.
Palkar and B. K. Philip. Department of Toxicology,
University of Louisiana, Monroe, LA.
#300
INVOLVEMENT OF DEATH PROTEINS
AND THEIR ENDOGENOUS INHIBITORS
IN PROGRESSION AND REGRESSION OF
HEMOLYTIC INJURY. P. S. Palkar, B. K. Philip
and H. M. Mehendale. Department of Toxicology,
University of Louisiana at Monroe, Monroe, LA.
#301
#302
#303
EFFECTS OF AQUEOUS EXTRACTS OF
CIGARETTE MAINSTREAM SMOKE
ON THE NOREPINEPHRINE-INDUCED
CONTRACTION OF RAT AORTIC RINGS IN
VITRO. T. Wallerath, K. von Holt and R. Schleef.
Philip Morris Research Laboratories GmbH,
Cologne, Germany. Sponsor: H. Haussmann.
ACID-LEACHABLE COMPONENTS OF
AMBIENT PARTICULATE MATTER DISRUPT
ENDOTHELIAL MONOLAYER INTEGRITY
AND ENHANCE α-ADRENERGIC AGONISTCAUSED CONSTRICTION OF RAT AORTA
RINGS. D. Wang, T. Wang and B. Zhao. College of
Pharmacy, University of South Carolina, Columbia,
SC. Sponsor: W. Su.
MECHANISM OF ADVERSE EFFECTS OF
UNOPPOSED ESTROGEN REPLACEMENT
THERAPY ON THE GROWTH OF
ENDOTHELIAL CELLS. Q. Felty and A. E.
Leisy. Florida International University, Miami, FL.
#305
PPARα ACTIVATION DISRUPTS PCBINDUCED PROINFLAMMATORY
SIGNALING PATHWAYS IN VASCULAR
ENDOTHELIAL CELLS. X. Arzuaga, G. Reiterer,
Z. Majkova, M. W. Kilgore, M. Toborek and B.
Hennig. University of Kentucky, Lexington, KY, KY.
ACROLEIN-INDUCED ENDOTHELIUMDEPENDENT VASODILATATION IN RODENT
MESENTERIC BED: AN NO-INDEPENDENT
MECHANISM. S. O. Awe2, A. S. Adeagbo2, S.
E. D’Souza2, A. Bhatnagar1 and D. J. Conklin1.
1
Cardiology, University of Louisville, Louisville,
KY and 2Physiology and Biophysics, University of
#307
CHRONIC ALCOHOL-INDUCED
HYPERTENSION AND AORTIC REACTIVITY
RESPONSES IN RATS. K. Husain, M. V. Ortiz
and J. L. Ortiz. Pharmacology and Toxicology, Ponce
School of Medicine, Ponce, Puerto Rico.
#308
ISIS 326358 AN ANTISENSE
OLIGONUCLEOTIDE TARGETED TO APOB
REDUCES PLASMA LDL-C IN A MONKEY
MODEL OF HYPERLIPIDEMIA. T. Kim1, S.
H. Rose2, K. Kramer-Stickland1, M. J. Graham1,
K. Subramaniam1, R. M. Crooke1, P. B. Lappin2,
G. S. Elliot2, A. A. Levin1 and S. P. Henry1. 1ISIS
Pharmaceuticals, Inc., Carlsbad, CA and 2Charles
River Laboratories, Sparks, NV.
#309
CHRONIC CIGARETTE MAINSTREAM
SMOKE EXPOSURE INCREASES PLAQUE
SIZE IN THE BRACHIOCEPHALIC ARTERY
IN APOLIPOPROTEIN E-DEFICIENT MICE
ON CHOW AND MILK-FAT-ENRICHED
DIETS. S. Lebrun, W. Stinn, H. Weiler, P. Kuhl, K.
von Holt, T. Wallerath and R. Schleef. Philip Morris
Research Laboratories GmbH, Cologne, Germany.
Sponsor: H. Haussmann.
#310
IN VIVO TREATMENT WITH
ANTIRETROVIRALS INDUCES
ENDOTHELIAL DYSFUNCITON AND
EXACERBATES ATHEROGENESIS. B.
Jiang, V. Y. Hebert, J. H. Zavecz and T. R. Dugas.
Pharmacology, LSU Health Sciences Center,
Shreveport, LA.
Monday Afternoon
EFFECT OF AMINOREX IN A HYPOXIAINDUCED PULMONARY HYPERTENSION
MODEL IN MICE. C. E. Perrone1, M. J.
Iatropoulos1, G. L. Fisher2 and G. M. Williams1.
1
Pathology, New York Medical College, Valhalla, NY
and 2Research, Wyeth, Collegeville, PA.
#304
#306
Monday, March 6
12:00 NOON to 1:30 PM
Exhibit Hall
45TH ANNIVERSARY RAFFLE CONTEST
SOT 45th Anniversary Raffle Contest will be held in the Exhibit Hall
Monday, Tuesday, and Wednesday between 12:00 NOON and 1:30 PM. As
part of the 45th Anniversary Celebration, SOT will be giving away a total
of $4500 over a three-day period! More details and contest rules are on the
SOT Annual Meeting Web site at www.toxicology.org and in the Exhibit
Hall on-site.
82
45th Annual
Meeting & ToxExpo
Monday, March 6
12:00 NOON to 1:30 PM
Room 4
#312
1:35
TEMPORAL CORRELATION OF
PATHOLOGY AND MARKERS OF
OXIDATIVE STRESS WITH GENE
EXPRESSION IN RAT LIVER
CARCINOGENESIS. I. Rusyn and C. Powell.
University of North Carolina at Chapel Hill, Chapel
Hill, NC.
#313
2:10
EXPLOITING PHENOTYPIC ANCHORING
TO REVEAL GENE EXPRESSION
INDICATORS OF INCIPIENT TOXICITY. R.
S. Paules and N. Members of the NCT ToxPath
Team. National Center for Toxicogenomics,
National Institute of Environmental Health Sciences,
#314
2:45
GASTROINTESTINAL TOXICITY AS A
CONTRIBUTOR TO HEPATOTOXICITY
ASSOCIATED WITH A P38 ALPHA KINASE
INHIBITOR. H. Hamadeh. Toxicology, Amgen
Inc., Thousand Oaks, CA.
#315
3:20
COMPARATIVE ANALYSIS OF THE
RODENT UTEROTROPIC RESPONSE:
IDENTIFICATION OF CONSERVED
RESPONSES AND MECHANISMS OF
ACTION. T. Zacharewski. Biochemistry, Michigan
#316
3:55
GENETIC VARIATION AS A NEW
DIMENSION IN TOXICOLOGY. D. Threadgill1,
2, 4
, I. Rusyn3, 2, 4, A. Hege4, A. Bissahoyo4 and M. La
Merrrill4. 1Genetics, University of North Carolina,
Chapel Hill, NC, 2Center for Environmental Health
and Susceptibility, University of North Carolina,
Chapel Hill, NC, 3Environmental Sciences and
Engineering, University of North Carolina, Chapel
Hill, NC and 4Curriculum in Toxicology, University
of North Carolina, Chapel Hill, NC.
SPECIALTY SECTION MEETING/RECEPTION: COMPARATIVE
AND VETERINARY
Monday, March 6
12:00 NOON to 1:30 PM
Room 3
SPECIALTY SECTION MEETING/RECEPTION: OCCUPATIONAL
AND PUBLIC HEALTH
Monday, March 6
1:30 PM to 4:30 PM
Room 6F
SYMPOSIUM SESSION: ADVANCING TOXICOLOGY BY
IMPROVING LINKAGE OF TRADITIONAL TOXICITY AND
PATHOLOGY ENDPOINTS WITH TOXICOGENOMICS
Chairperson(s): Ivan Rusyn, University of North Carolina Chapel Hill,
Chapel Hill, NC and Richard Paules, NIEHS, Research Triangle Park, NC.
Endorsed by:
Carcinogenesis SS
Mechanisms SS
Toxicogenomics has recently emerged as an extremely promising subdiscipline of environmental health sciences. It has received an enormous
amount of attention at a large number of international toxicology meetings
as a powerful, new tool for toxicologists that may considerably accelerate
discovery of the mechanisms of environment-associated diseases, reveal
novel biomarkers or surrogate biomarkers of both exposure and effect,
improve scientists’ ability to characterize hazard, and serve as a foundation
for advancing risk assessment. Careful assessment of linkages between
the omics data and conventional parameters of toxicity is very important
for both validation and evaluation of toxicogenomics data. Phenotypic
anchoring of gene expression data to toxicological and pathological indices
removes the subjectivity of novel molecular analyses and is important to
distinguish the toxicological effect from changes that may be unrelated to
toxicity. Importantly, several recent studies demonstrated the utility of this
approach and showed how a careful examination of different types of the
data available to the toxicologists today helps to understand organ-specific
toxic events, identify conserved responses across species, and bring other
disciplines, such as genetics, into the toxicology research. Collectively, the
linkage of toxicogenomic data to specific sites within tissues and specific
cellular populations in affected tissues should result in better selection of
appropriate animal models, reduction in the number of animals used, and
enhanced insight into pathways of toxicity and disease processes that have
been heretofore unattainable, ultimately enhancing risk assessment.
#311
1:30
ADVANCING TOXICOLOGY BY IMPROVING
LINKAGE OF TRADITIONAL TOXICITY
AND PATHOLOGY ENDPOINTS WITH
TOXICOGENOMICS. I. Rusyn1 and R. Paules2.
1
University of North Carolina at Chapel Hill, Chapel
Hill, NC and 2National Center for Toxicogenomics,
NIEHS, Research Triangle Park, NC.
83
MONDAY
45th Annual
Meeting & ToxExpo
#322
Monday, March 6
1:30 PM to 4:30 PM
Room 7B
3:55
SYMPOSIUM SESSION: THE BIOLOGICAL MATRIX OF IN
VITRO SYSTEMS AND THEIR USE IN TOXICOLOGY
THE USE OF AN IN VITRO SCREENING
ASSAYS TO PREDICT HUMAN SENSITIVITY.
J. E. Tomaszewski. Division of Cancer Treatment
and Diagnosis, National Cancer Institute, Bethesda,
MD. Sponsor: S. Green.
Chairperson(s): Alan Goldberg, Johns Hopkins University, Baltimore, MD
and Sydney Green, Howard University, Washington, DC.
Monday, March 6
1:30 PM to 4:30 PM
Room 6E
Endorsed by:
In Vitro SS*
National Capital Area Chapter
Risk Assessment SS
SYMPOSIUM SESSION: INDIRECT MECHANISMS OF
TOXICITY: ADVANCING OUR UNDERSTANDING OF
NEUROENDOCRINE-IMMUNE INTERACTIONS
MONDAY
The basic biological unit of toxicology, as it evolved over the last 100
years, has been the laboratory rodent. The laboratory rodent was first
introduced by E.V. McCollum for nutritional studies the early part of the
last century. For some 50 years, the animal was not standardized, and was
the largest variable in any animal based research A significant advance
was the standardization of the laboratory rodent by Henry Foster and
the formation of Charles River Laboratories to provide animals that are
the same from order to order. By standardizing the laboratory rodent, it
became possible for laboratories in Europe, the United States, and Japan to
actually be able to reproduce studies and know that the potentially largest
variable, the animal, was now controlled. The advances made with animals
has significantly improved the health of both animals and humans populations, resulting in an expanded life span and an enhanced quality of life. As
science advanced and more specific questions could be asked- experiments
to understand mechanisms and mode of action and studies aimed at subcellular and molecular components of cells- it became necessary to learn to
culture cells (both human and animal) to further understand biology and
the effects of drugs and chemicals on their function. Today, many new and
exciting approaches are available for the scientist - from using monolayers
of cells to three-dimensional reconstituted tissues, to multiple cell types
allowing the understanding of the interaction between complex systems.
These newer systems and different biological matrixes offer the opportunity to advance science and our understanding of the underlying biology
by yet another step. This symposium presents some of these systems and
focuses on their use in toxicological studies.
#317
1:30
THE BIOLOGICAL MATRIX OF IN VITRO
SYSTEMS AND THEIR USE IN TOXICOLOGY.
A. Goldberg1 and S. Green2. 1Environmental Health
Sciences, John Hopkins University, Baltimore, MD
and 2Pharmacology, Howard University, Washington,
DC.
#318
1:35
USE OF HUMAN CELL LINES FOR IN VITRO
STUDIES. M. Ehrich. Biomedical Sciences and
Pathobiology, Virginia Tech, Blacksburg, VA.
#319
2:10
APPLICATIONS OF RECONSTRUCTED 3-D
IN VITRO TISSUE MODELS IN TOXICOLOGY.
P. J. Hayden, J. Kubilus, S. Ayehunie, Y. Kaluzhny,
J. E. Sheasgreen and M. Klausner. MatTek Corp.,
Ashland, MA.
#320
2:45
“ANIMAL-ON-A-CHIP”: TOWARDS
PREDICTIVE TOXICOLOGY. M. L. Shuler.
Biomedical Engineering, Cornell University, Ithaca,
NY. Sponsor: S. Green.
#321
3:20
TOXICITY TESTING USING STEM CELL
ASSYAS. D. A. Casciano. Office of the Director,
NCTR, Jefferson, AR.
84
Chairperson(s): Leigh Ann Burns-Naas, Pfizer Global Research &
Development, San Diego, CA and Virginia Sanders, Ohio State University,
Columbus, OH.
Endorsed by:
Immunotoxicology SS
Neurotoxicology SS
Women in Toxicology SS
There is overwhelming evidence that cytokines, neuropeptides, neurotransmitters, and hormones, as well as their receptors, are an integral and
inter-regulated part of the central nervous system, the endocrine system,
and the immune system. Immune cells synthesize and secrete peptide
hormones and neurotransmitters, which can have autocrine (immune
system) and paracrine (endocrine and nervous systems) effects. Additionally, nerve terminals containing neurotransmitters have been found
in lymphoid tissues in close association with lymphoid cells, and the
neurotransmitter is released when an antigen insult is present. Also, receptors for neuropeptides, neurotransmitters, and hormones are present on
lymphoid cells. These findings make it reasonable to suspect that some
chemicals may exert their immunomodulatory effects indirectly on the
immune system, by acting to modulate the activity of the nervous or
endocrine systems. It is now critical that we begin to address the probable
role played by neuroendocrine-immune interactions in a chemical-induced
immune toxicity that may involve multiple organ systems. The goal of this
symposium is to describe advances in our understanding of the role of the
neuroendocrine-immune axis in chemical toxicity and human health.
#323
1:30
INDIRECT MECHANISMS OF TOXICITY:
ADVANCING OUR UNDERSTANDING
OF NEUROENDOCRINE – IMMUNE
INTERACTIONS. L. Burns Naas1 and V. M.
Sanders2. 1Worldwide Safety Sciences, Pfizer
Global Research & Development, San Diego, CA
and 2Molecular Virology, Immunology & Medical
Genetics, The Ohio State University Medical Center,
Columbus, OH.
#324
1:50
NON-IMMUNE MECHANISMS FOR
REGULATING THE LEVEL OF IMMUNITY.
V. M. Sanders. Molecular Virology and Immunology,
The Ohio State University Columbus, OH.
#325
2:30
MODELING AND PREDICTING THE
IMMUNOLOGICAL EFFECTS OF
CHEMICAL AND DRUG INDUCED STRESS
RESPONSES IN MICE. S. B. Pruett, C. Schwab,
R. Fan, P. Myers and Q. Zheng. Cell. Biol. &
Anatomy, LSU Health Sciences Center, Shreveport,
LA.
45th Annual
Meeting & ToxExpo
#326
#327
3:10
3:50
IMPACT OF PSYCHOLOGICAL AND
ENVIRONMENTAL FACTORS ON ASTHMA:
FROM ENVIRONMENT TO BENCH TO
BEDSIDE. G. D. Marshall. Medicine, University of
Mississippi Medical Center, Jackson, MS. Sponsor:
L. Burns-Naas.
CHILDREN’S HEALTH RISK - CAN
ECONOMIC INEQUALITIES IMPACT THE
NEUROIMMUNE INTERFACE AND HEALTH?
D. A. Lawrence, N. Pabello and J. Kasten-Jolly.
Wadsworth Center, Albany, NY.
Monday, March 6
1:30 PM to 4:30 PM
Room 2
#329
1:35
COMPARATIVE PATHOLOGY OF
HEMANGIOSARCOMA. D. E. Malarkey.
National Institute of Environmental Health Sciences,
Research Triangle Park, NC. Sponsor: D. Pegg.
#330
2:05
INDUCTION OF HEPATIC
HEMANGIOSARCOMA BY VINYL
CHLORIDE: DOSE-RESPONSE AND MODE
OF ACTION. J. A. Swenberg. Environmental
Sciences and Engineering, University of North
Carolina, Chapel Hill, NC.
#331
2:35
EPIGENETIC MECHANISMS OF
HEMANGIOSARCOMA INDUCTION. J. E.
Klaunig. Pharmacology and Toxicology, Indiana
University, Indianapolis, IN.
#332
3:05
INVESTIGATIVE APPROACHES TO
UNDERSTANDING THE MODE OF ACTION
AND HUMAN RELEVANCE OF PPARγ
AGONIST INDUCED HEMANGIOSARCOMAS
IN MICE. R. D. Storer. Safety Assessment, Merck
Research Laboratories, West Point, PA.
#333
3:35
REGULATORY PERSPECTIVE ON
RECEPTOR (PPAR) INDUCED TUMORS
INCLUDING HEMANGIOSARCOMA. J. D.
ElHage. Division of Metabolic and Endocrine Drug
Products, Food and Drug Administration, Rockville,
MD.
#334
4:05
EPIGENETIC MODE OF ACTION
ASSOCIATED WITH INDUCTION OF
HEMANGIOSARCOMA IN MICE. D. G.
Pegg, Z. Wojcinski, K. Criswell, J. Herman and T.
Anderson. World Wide Safety Sciences, Pfizer, Ann
Arbor, MI.
SYMPOSIUM SESSION: MODE OF ACTION ASSOCIATED
WITH INDUCTION OF ENDOTHELIAL CELL TUMORS—
HEMANGIOSARCOMA
Chairperson(s): David Pegg, Pfizer Global Research & Development, Ann
Arbor, MI and Brian Short, Allergan, Inc., Irvine, CA.
Endorsed by:
Carcinogenesis SS*
Mechanisms SS
Toxicologic and Exploratory Pathology SS
Hemangiosarcoma is an aggressive, malignant tumor of endothelial
cells that is rare in humans. In the 12 regions of the US National Cancer
Institutes Surveillance, Epidemiology, and End Results (SEER) database, the incidence rate of hemangiosarcoma between 1996 and 2000
was 0.21 new cases per 100,000 people (0.00021%). Hemangiosarcoma
in humans commonly occurs on head and neck and is associated with
skin structures. Liver hemangiosarcoma is associated with exposure to
genotoxic compounds such as Thorotrast or vinyl chloride. In contrast,
hemangiosarcoma occurs spontaneously in liver, spleen, bone marrow,
lymph nodes and skin at a high incidence in rodents. The background
incidence in B6C3F1 mice reported from the National Toxicology
Program database is 5.4% in males and 2.7% in females with a range
from 0% to 12%. The incidence in Wistar rats ranges from 0 to 3.4 %.
These data suggest that mice are more susceptible to development of
spontaneous hemangiosarcoma than rats and much more susceptible
than humans. Hemangiosarcoma in rodents, primarily mice, has been
reported in the labeling of a number of marketed drug products and in
the literature with several chemicals. Some of these compounds demonstrated genotoxic potential in nonclinical testing and thus a plausible
mechanism for tumor induction involving DNA adduct formation. Others, however, are clearly nongenotoxic and a mode of action is more
difficult to establish. Regardless, findings of hemangiosarcoma have
significant impact on decisions made regarding further development
of these agents and future usage. Recent research has provided a great
deal of information on epigenetic processes of tumorigenesis involving
oxidative stress, altered gene expression and species differences related
to endothelial homeostasis that provide a basis for risk assessment.
#328
1:30
MODE OF ACTION ASSOCIATED WITH
INDUCTION OF ENDOTHELIAL CELL
TUMORS - HEMANGIOSARCOMA. D. G.
Pegg1 and B. Short2. 1World Wide Safety Sciences,
Pfizer Global Research and Development, Ann
Arbor, MI and 2Drug Safety Evaluation, Allergan,
Inc., Irvine, CA.
85
MONDAY
45th Annual
Meeting & ToxExpo
Monday, March 6
1:30 PM to 4:30 PM
Room 6B
#336
1:45
COMBINED PB EXPOSURE AND
ENVIRONMENTAL STRESS:
CONSEQUENCES FOR THE CNS AND THE
HPA AXIS. D. Cory-Slechta. Environmental
and Occupational Medicine, Environmental and
Occupational Health Sciences Institute, University
Med. Dent New Jersey, Piscataway, NJ.
#337
2:15
CNS EFFECTS OF LEAD IN ADULT
HUMANS: NEW EVIDENCE FROM
LONGITUDINAL STUDIES OF
NEUROBEHAVIORAL FUNCTION AND
STRUCTURAL MRI. D. Cory-Slechta.
Environmental and Occupational Medicine,
Environmental and Occupational Health Sciences
Institute, University Med. Dent New Jersey,
Piscataway, NJ.
#338
2:55
CHRONIC DEVELOPMENTAL EXPOSURE
TO LEAD (PB) IMPAIRS HIPPOCAMPAL
FUNCTION. M. E. Gilbert1 and S. M. Lasley2.
1
Neurotoxicology, U.S. EPA, Research Triangle Park,
NC and 2Biomed Therap Sciences, University of
Illinois, Peoria, IL.
#339
3:25
IN VITRO MODELS OF NEURAL RESPONSES
TO LEAD (PB). E. Tiffany-Castiglioni, Y. Qian
and Y. Zheng. Integrative Biosciences, Texas A&M
University, College Station, TX.
#340
3:55
PB AND ALZHEIMER’S DISEASE. N. H.
Zawia and R. B. Mahammad. Biomedical and
Pharmaceutical Sciences, University of Rhode
Island, Kingston, RI.
SYMPOSIUM SESSION: NEW CONCEPTS IN THE
NEUROTOXICOLOGY OF LEAD
Chairperson(s): Lori White, U.S. EPA, Research Triangle Park, NC and
Deborah Cory-Slechta, University of Medicine and Dentistry of New
Jersey, Piscataway, NJ.
Endorsed by:
Metals SS
Neurotoxicology SS*
Risk Assessment SS
MONDAY
Lead is a xenobiotic metal with no historically known function in cellular
growth, proliferation, or signaling. Decades of research characterizing the
toxicology of lead have shown it to be a potent neurotoxicant, especially
during nervous system development. New concepts in the neurotoxicology
of lead include advances in understanding the mechanisms and cellular
specificity of lead. Environmental factors such as stress and socioeconomic status have been shown to potentiate the effects of lead through
elevated glucocorticoid levels acting on the mesocorticolimbic system.
New structural MRI studies have shown relationships of lead to alterations
in CNS volumes and to the prevalence and severity of white matter lesions.
Cellular models of learning and memory have been utilized to investigate
the potential mechanisms of Pb-induced cognitive deficits. Examination of
long-term potentiation in the rodent hippocampus has revealed Pb-induced
increases in threshold, decreases in magnitude, and shorter retention times
of synaptic plasticity. Structural plasticity in the form of adult neurogenesis in hippocampus is also impacted by Pb exposure. The action of lead
on glutamate release, NMDA receptor function, or growth factor expression may underlie perturbations in synaptic plasticity and contribute to
learning impairments. Evidence is also mounting that lead can accumulate
in astroglial cells by utilizing the cellular transport systems normally used
for essential minerals such as calcium. Additionally, glial cells may use
glucose regulated protein (GRP78), a molecular chaperone in the endoplasmic reticulum, to temporarily bind lead during the lead accumulation
process. However, this binding may contribute to increased susceptibility
of the brain to stress, as GRP78 is also a stress protein and a chaperone for
interleukine-6. Lead exposure in early life has been implicated in subsequent progression of Alzheimers Disease (AD) in rodents. This exposure
caused upregulation of mRNA coding for beta-amyloid precursor protein,
which is cleaved into beta-amyloid peptides associated causally with AD.
This new body of research presents compelling evidence that even very
low exposures of lead have adverse effects on the nervous system, that
environmental and genetic factors increase nervous system susceptibility to
lead, and that exposures in early life cause neurodegeration in later life.
#335
1:30
NEW CONCEPTS IN THE
NEUROTOXICOLOGY OF LEAD. L. White1, D.
A. Cory-Slechta2, B. S. Schwartz6, M. E. Gilbert4,
E. C. Tiffany-Castiglioni3 and N. H. Zawia5.
1
NCEA, U.S. EPA, Research Triangle Park, NC,
2
Environmental and Occupational Health Sciences
Institute, University of Medicine and Dentistry of
New Jersey and Rutgers, Piscataway, NJ, 3Veterinary
Anatomy and Public Health, Texas A&M, College
Station, TX, 4Neurotoxicology Division, U.S.
EPA, Research Triangle Park, NC, 5University
Rhode Island, Kingston, RI and 6Occupational and
Environmental Health, Johns Hopkins University,
Baltimore, MD.
86
Monday, March 6
1:30 PM to 4:30 PM
Room 8
SYMPOSIUM SESSION: NEW INSIGHTS INTO MECHANISMS
OF CELL DEATH AND SURVIVAL
Chairperson(s): John Robertson, University of Kansas Medical Center,
Kansas City, KS and Shawn Bratton, University of Texas at Austin, Austin,
TX.
Endorsed by:
Mechanisms SS*
Tight regulation of cell death and survival is key for normal embryonic
development and the maintenance of tissue turnover or homeostasis. Tissue
homeostasis occurs when a balance is achieved between cell renewal
and cell death so that no net change in cell number is present. Normal
homeostatic cell deletion is controlled, at least in part, by apoptosis. Consequently, dysregulation of apoptotic cell death has been implicated in the
onset of numerous pathologies, including liver and autoimmune disorders,
cardiovascular disease, and cancer. Further, environmental factors that
contribute to an increased risk of these diseases appear to do so, at least in
part, by disrupting the balance between cell death and survival. Likewise,
preventive and therapeutic measures to control these diseases are often
designed to block aberrant cell death or survival. Whether a cell survives
or dies in the presence of a toxic stimulus is often determined by proliferative status, repair enzyme capacity, and/or the ability to induce or activate
proteins that either promote or inhibit apoptotic cell death. Although the
underlying molecular and biochemical mechanisms, in some cases, are at
least partially understood, in many other instances they remain unclear.
This symposium will present important new insights into mechanisms
regulating cell death or survival in response to toxic stimuli. With a diverse
45th Annual
Meeting & ToxExpo
#341
1:30
NEW INSIGHTS INTO MECHANISMS OF
CELL DEATH AND SURVIVAL. J. D. Robertson1
and S. B. Bratton2. 1Pharmacology, Toxicology &
Therapeutics, University of Kansas Medical Center,
Kansas City, KS and 2Division of Pharmacology
and Toxicology, The University of Texas at Austin,
Austin, TX.
#342
1:35
TOPOISOMERASE II INHIBITORS AND
CELL DEATH. J. D. Robertson, P. Bu and E. E.
Franklin. Pharmacology, Toxicology & Therapeutics,
University of Kansas Medical Center, Kansas City,
KS.
#343
2:10
MITOCHONDRIAL AND POSTMITOCHONDRIAL PROSURVIVAL
MECHANISMS IN SRTESSED CELLS.
D. G. Tang, J. Liu, G. Choy and D. Chandra.
Carcinogenesis, The University of Texas MD
Anderson Cancer Center, Smithville, TX, TX.
Sponsor: S. Bratton.
#344
2:45
NOVEL MECHANISMS OF HEAT SHOCKINDUCED APOPTOSIS. S. B. Bratton and R. S.
Milleron. Division of Pharmacology and Toxicology,
The University of Texas at Austin, Austin, TX.
#345
3:20
BOTH BID-DEPENDENT AND BIDINDEPENDENT APOPTOTIC PATHWAYS
ARE INVOLVED IN TNFα-INDUCED
HEPATOCYTE APOPTOSIS. X. Yin, W. Ding, H.
Ni and X. Chen. Pathology, University of Pittsburgh
Shool of Medicine, Pittsburgh, PA. Sponsor: J.
Robertson.
#346
3:55
STEROID HORMONE INDUCED
CELL SURVIVAL RESPONSE IN
CARDIOMYOCYTES. Q. M. Chen, H. Sun,
S. Morrissy, L. Xie, Y. Lin and D. Alexander.
Pharmacology, University of Arizona, Tucson, AZ.
#347
1:30
ADVANCES IN ASBESTOS TOXICOLOGY
AND EXPOSURE ASSESSMENT. E. L.
Hofmann1, A. Koppikar2, M. Maddaloni3, A.
Koppikar2, E. L. Hofmann1, E. Kuempel1, T.
Hei4, J. Verkouteren5 and M. Maddaloni3. 1Office
of Solid Waste and Emergency Response, U.S.
EPA, Washington, DC, 2Office of Research and
Development, U.S. EPA, Washington, DC, 3Region
2, U.S. EPA, New York, 4Columbia University,
New York and 5National Institute of Standards and
Technology, Rockville, MD.
#348
2:00
ASBESTOS NONCANCER EFFECTS
- INTEGRATED RISK INFORMATION
SYSTEM (IRIS)UPDATE. A. Koppikar. ORD/
NCEA-W, U.S. EPA, Washington, DC. Sponsor: E.
Hofmann.
#349
2:30
FIBER SIZE-SPECIFIC EXPOSURE
ESTIMATES AND UPDATED MORTALITY
ANALYSIS OF CHRYSOTILE ASBESTOS
TEXTILE WORKERS. E. D. Kuempel1, L. T.
Stayner2, 1, J. D. Dement3, S. J. Gilbert1 and M. J.
Hein1. 1National Institute for Occupational Safety
and Health, Cincinnati, OH, 2University of Illinois,
Chicago, IL and 3Duke University Medical Center,
Durham, NC. Sponsor: L. Hofmann.
#350
3:00
MECHANISMS OF FIBER
CARCINOGENESIS: FROM
MITOCHONDRIAL DAMAGE TO SILENCING
OF THE BIGH3 GENE. T. K. Hei1, 2. 1Center for
Radiological Research, Columbia University, New
York, NY, NY and 2Environmental Health Sciences,
Columbia University, New York. Sponsor: E.
Hofmann.
#351
3:30
AN OVERVIEW OF ASBESTOS COUNTING
TECHNOLOGIES. J. Verkouteren. NIST,
Gaithersburg, MD. Sponsor: E. Hofmann.
#352
4:00
ASSESSING ASBESTOS HAZARDS IN THE
INDOOR ENVIRONMENT. M. A. Maddaloni.
U.S. EPA, New York.
Monday, March 6
1:30 PM to 4:30 PM
Room 15A
WORKSHOP SESSION: ADVANCES IN ASBESTOS TOXICOLOGY
AND EXPOSURE ASSESSMENT
Chairperson(s): Elizabeth Lee Hofmann, U.S. EPA, Washington, DC and
Mark Maddaloni, U.S. EPA, New York, NY.
Endorsed by:
Risk Assessment SS
Occurrences of asbestos-related contamination, such as the vermiculite
mine in Libby, Montana, and the World Trade Center, have highlighted
the need to update the state of science with regard to asbestos toxicity
and exposure assessment. The purpose of this workshop is not only to
provide an overview for toxicologists, but also to highlight the advances in
a number of important areas. Recent work by U.S. EPA in examining the
carcinogenic and non-carcinogenic effects of asbestos will be presented.
The technical issues of assessing asbestos hazard in an indoor environment are presented. New data from NIOSH will update the dose-response
analysis of the mortality of textile workers. Research into cellular and
molecular mechanisms of lung and pleural diseases is opening up new
87
MONDAY
hypotheses on the mechanisms of action of asbestos toxicity. In the area
of asbestos exposure assessment, improvements in analytical and counting
methodologies will be discussed. This presentation will also provide some
preliminary results of a sensitivity analysis being conducted by EPA on a
quantitative cancer model that divides asbestos fibers into four bins (diameter < .4um), as a function of mineral type (chrysotile versus amphiboles),
and length (5-10um, > 10 um). EPA has been working to establish quantitative uncertainty bounds around the fitted model parameter estimates and
performing sensitivity analyses to help characterize confidence in these
values. The preliminary results for lung cancer indicate that confidence
in the fitted parameters shows that the best results are obtained for the
potency values for the long fibers, as compared to the potency values for
shorter fibers.
combination of perspectives, this session will appeal broadly to those who
are interested in studies of the molecular and biochemical mechanisms of
cell death and survival.
45th Annual
Meeting & ToxExpo
Monday, March 6
1:30 PM to 4:30 PM
Room 7A
#360
3:50
THE DIFFERENTIAL RECRUITMENT OF
ERα TO CYP1A1 BY BNF, ICZ, AND DIM AND
THE IMPORTANT ROLE OF ERα IN AHR
TRANSCRIPTION. B. Wihlen1, N. Heldring1, E.
Treuter1, L. Helguro1, L. Haldosen1, J. Gustafsson2
and J. Matthews1. 1Department of Biosciences,
Karolinska Institute, Huddinge, Sweden and
2
Medical Nutrition, Karolinska Institutet, Huddinge,
Sweden.
#361
4:10
PCB126, BUT NOT PCB104 INDUCES
RECRUITMENT OF ERα TO AHR TARGET
GENES. J. Matthews1, B. Wihlen1, N. Heldring1,
E. Treuter1, L. Helguro1, L. Haldosen1 and
J. Gustafsson1. 1Department of Biosciences,
Karolinska Institute, Huddinge, Sweden and
2
Medical Nutrition, Karolinska Institutet, Huddinge,
Sweden.
PLATFORM SESSION: AH RECEPTOR II
Chairperson(s): Michael Denison, University of California Davis, Davis,
CA and Mary Walker, University of New Mexico, Albuquerque, NM.
#353
#354
#355
MONDAY
#356
1:30
1:50
2:10
2:30
DIFFERENTIAL RESPONSIVENESS OF THE
AH RECEPTOR TO HAHS AND PAHS. B. Zhao,
J. E. Bohonowych and M. S. Denison. Department of
Environmental Toxicology, University of California,
Davis, CA.
HOMOLOGY MODELING AND
MUTAGENESIS OF THE MOUSE AHR
LIGAND BINDING DOMAIN. M. Denison1, Y.
Song1, A. Pandini2, A. Soshilov1, C. Sorrentino1
and L. Bonati2. 1Department of Environmental
Toxicology, University of California, Davis, CA and
2
di Scienze e del Territoria, Universita degli Studi di
Milano-Bicocca, Milano, Italy.
Monday, March 6
1:30 PM to 4:30 PM
Room 5A
ENDOTHELIN-1-MEDIATED INCREASE IN
REACTIVE OXYGEN SPECIES AND NAD(P)H
OXIDASE ACTIVITY IN HEARTS OF ARYL
HYDROCARBON RECEPTOR (AHR) NULL
MICE. A. K. Lund, S. L. Peterson, G. S. Timmins
and M. K. Walker. College of Pharmacy, University
of New Mexico, Albuquerque, NM.
PLATFORM SESSION: DEVELOPMENTAL TOXICITY IN VIVO
AND IN VITRO INVESTIGATIONS
Chairperson(s): Edward Puzas, University of Rochester School of
Medicine, Rochester, NY and Barbara Abbott, Environmental Protection
Agency, Research Triangle Park, NC.
CHARACTERIZATION OF HSP90-BINDING
TO THE AH RECEPTOR, CENTRAL ROLE OF
THE PASB DOMAIN. A. Soshilov1, A. Pandini2, L.
Bonati2 and D. Michael1. 1Environmental Toxicology,
UCDavis, Davis, CA and 2Dipartimento di Scienze
e del Territoria, Universita degli Studi di MilanoBicocca, Milano, Italy.
#357
2:50
THE ROLE OF ENDOGENOUS XAP2 IN
THE SUBCELLULAR LOCATION AND
NUCLEOCYTOPLASMIC SHUTTLING OF
THE ENDOGENOUS AHB-1 RECEPTOR. S.
Wilson and R. S. Pollenz. Biology, University of
South Florida, Tampa, FL.
#358
3:10
3-METHYLCHOLANTHRENE AND OTHER
ARYL HYDROCARBON RECEPTOR
AGONISTS DIRECTLY ACTIVATE
ESTROGEN RECEPTOR ALPHA. M.
Abdelrahim1, E. Ariazi2, K. Kim1, S. Khan1, R.
Barhoumi1, R. Burghardt1, S. Liu1, B. Wlodarczyk1,
D. Hill1, R. Finnell1, V. Jordan22 and S. Safe1. 1Texas
A&M University, Houston, TX and 2Fox Chase
Cancer Center, Philadelphia, PA.
#359
3:30
MALIGNANT TRANSFORMATION OF
MAMMARY EPITHELIAL CELLS BY
OVER-EXPRESSION OF THE ARYL
HYDROCARBON RECEPTOR. J. Brooks and S.
E. Eltom. Biomedical Sciences, Division of Cancer
Biology, Meharry Medical College, Nashville, TN.
88
#362
1:30
DI-(2-ETHYLHEXYL)-PHTHALATE
AFFECTS LIPID PROFILING IN THE FETAL
RAT BRAIN UPON IN UTERO EXPOSURE.
T. J. Cook, Y. Xu and G. T. Knipp. Department of
Pharmaceutics, Rutgers, The State University of
New Jersey, Piscataway, NJ.
#363
1:50
VASCULAR DYSMORPHOGENESIS CAUSES
PLACENTAL INSUFFICIENCY AND
MISCARRAIGE IN ARSENIC EXPOSED
MICE. J. Coffin, R. J. Greenwell, D. M. Brooks,
L. G. Calderon and H. D. Beall. Center for
Enviromental Health Sciences, University of
Montana, Missoula, MT.
#364
2:10
MAGNETIC RESONANCE IMAGING
AS A NON- INVASIVE TOOL IN
DEVELOPMENTAL TOXICOLOGY:
COMBINED EFFECTS OF CADMIUM
(CD) AND PARASITE INFECTION ON
AMPHIBIAN MALFORMATIONS. J. A. Gross1,
P. T. Johnson2, L. K. Prahl1, W. H. Karasov1, B.
Guenther3, B. Johnson3, C. Gaul3, R. R. Maronpot4
and K. Johnson4. 1Wildlife Ecology, University of
Wisconsin - Madison, Madison, WI, 2Center for
Limnology, University of Wisconsin - Madison,
Madison, WI, 3MRPath Inc., Durham, NC and
4
Laboratory of Experimental Pathology, NIEHS/
NIH/DHHS, Research Triangle Park, NC.
#365
2:30
PB REGULATES MESENCHYMAL STEM
CELL GENE EXPRESSION IN A WAY
THAT MAY EXPLAIN ITS EFFECTS ON
SKELETAL GROWTH. E. Puzas, L. Ma, M.
J. Zuscik, E. M. Schwarz, R. N. Rosier and R. J.
O’Keefe. Department of Orthopaedics, University of
Rochester School of Medicine, Rochester, NY.
45th Annual
Meeting & ToxExpo
#366
2:50
DEVELOPMENT OF CATARACT
PHENOTYPE IN ALDH1A1-/-/ALDH3A1/DOUBLE KNOCKOUT MICE. N. Lassen1,
W. Black1, J. Kuszak2, B. Bateman3, D. Nees4,
J. Piatigorsky4, G. Duester5 and V. Vasiliou1.
1
Pharmaceutical Sciences, UCHSC, Denver,
CO., 2Ophthalmology and Pathology, RushPresbyterian-St. Luke’s Medical Center, Chicago,
IL, 3Ophthalmology and Pediatrics, Rocky Mountain
Lions Eye Institute, Denver, CO., 4Molecular and
Developmental Biology, NIH, Bethesda, MD and
5
OncoDevelopmental Biology Program, Burnham
Institute, La Jolla, CA.
#367
3:10
REDUCED INCIDENCE OF VALPROIC ACID
INDUCED NEURAL TUBE DEFECTS WITH
MATERNAL IMMUNE STIMULATION.
T. C. Hrubec1, 2, K. A. Toops2, M. Yang3, K. Ye3
and S. D. Holladay2. 1Department of Biomedical
Sciences, VA College of Osteopathic Medicine,
Blacksburg, VA, 2Department of Biomedical
Sciences and Pathobiology, VA-MD Regional
College of Veterianry Medicine, Blacksburg, VA and
3
Department of Statistics, VA Tech, Blacksburg, VA.
#368
3:30
TOWARD DEVELOPMENTAL TOXICOLOGY
IN VITRO: IMPLICATIONS OF GENE
EXPRESSION RESPONSES TO VALPROIC
ACID IN EMBRYOS AND IN VITRO MODELS.
M. Stigson1, K. Kultima1, M. Jergil1, B. Scholz1,
H. Alm1, A. Gustafson2 and L. Dencker1.
1
Pharmaceutical Biosciences, Uppsala University,
Uppsala, Sweden and 2Safety Assessment,
AstraZeneca R&D, Sodertalje, Sweden. Sponsor: K.
Ramos.
#369
3:50
EFFECTS OF PERFLUOROOCTANOIC ACID
(PFOA) ON MICE EXPOSED IN UTERO AT
SPECIFIC GESTATIONAL STAGES. B. D.
Abbott, C. J. Wolf, K. P. Das and C. S. Lau. RTD
(MD67), U.S. EPA/ORD/NHEERL, Research
Triangle Park, NC.
#370
4:10
CROSS-FOSTER STUDY OF THE
DEVELOPMENTAL EFFECTS OF PFOA. C.
J. Wolf, J. R. Thibodeaux, C. Lau and B. D. Abbott.
Reproductive Toxicology Division, U.S. EPA/
NHEERL/ORD, Research Triangle Park, NC.
Monday, March 6
1:30 PM to 4:30 PM
Room 5B
PLATFORM SESSION: HYPERSENSITIVITY
Chairperson(s): Katherine Sarlo, Procter & Gamble Company, Cincinnati,
OH and David Basketer, Unilever, Bedford, United Kingdom.
#371
1:30
CATALASE FROM A FUNGAL MICROBIAL
PESTICIDE INDUCES A UNIQUE IGE
RESPONSE. M. D. Ward1, L. B. Copeland1, M. J.
Donohue2, Y. Chung1, J. A. Shoemaker2 and S. J.
Vesper2. 1NHEERL, U.S. EPA, Research Triangle
Park, NC and 2NERL, U.S. EPA, Cincinnati, OH.
89
#372
1:50
MODULATION OF ALLERGIC ASTHMA
BY OAK DUST EXPOSURE IN MICE. K.
Savolainen1, J. Maatta1, M. Lehto1, M. Leino1,
S. Tillander1, R. Haapakoski1, H. Wolff2 and H.
Alenius1. 1Industrial Hygiene and Toxicology,
Finnish Institute of Occupational Health, Helsinki,
Finland and 2Occupational Medicine, Finnish
Institute of Occupational Health, Helsinki, Finland.
#373
2:10
EXPOSURE IS THE PROOF OF THE
PUDDING: OXAZOLONE IS A POTENTIAL
RESPIRATORY ALLERGEN. C. Mommers, J.
Arts, M. Schijf and F. Kuper. TNO Quality of Life,
Zeist, Netherlands. Sponsor: V. Feron.
#374
2:30
CYTOKINE RESPONSES TO DERMAL
ISOCYANATE EXPOSURE IN DRAINING
LYMPH NODES ARE NOT PREDICTIVE
OF AIRWAY RESPONSES AFTER AIRWAY
CHALLENGE. A. K. Farraj, E. H. Boykin, N.
Haykal-Coates, S. H. Gavett and M. K. Selgrade.
Experimental Toxicology Division, U.S. EPA,
#375
2:50
INITIAL INTERACTIONS OF ALLERGENS
WITH AIRWAY EPITHELIAL CELLS: ANY
ROLE IN THE INDUCTION OF TYPE I
ALLERGY? M. Baccam1, N. Soni2, L. Fridthjof2,
N. Berg2, K. Sarlo1 and E. Roggen2. 1Miami
Valley Laboratories, Procter & Gamble Company,
Cincinnati, OH and 2Novozymes, Bagsvaerd,
Denmark.
#376
3:10
IN VITRO CHARACTERIZATION OF
DENDRITIC CELL (DC) RESPONSES TO
A CHEMICAL ALLERGEN AND A SKIN
IRRITANT. C. Portsmouth1, M. Cumberbatch1,
C. Schramm1, R. J. Dearman1, G. Maxwell2, C.
Westmoreland2, D. A. Basketter2 and I. Kimber1.
1
Immunology, Syngenta CTL, Macclesfield, United
Kingdom and 2SEAC, Unilever, Bedford, United
Kingdom.
#377
3:30
THE REDUCED LLNA AS A HAZARD
IDENTIFICATION SCREEN FOR SKIN
SENSITISATION. D. A. Basketter1, G. Patlewicz2,
F. Gerberick3, C. Ryan3, P. Kern4, R. Dearman5 and
I. Kimber5. 1SEAC, Unilever, Sharnbrook, United
Kingdom, 2European Chemicals Bureau, Ispra, Italy,
3
P&G, Cincinnati, OH, 4P&G, Brussels, Belgium
and 5Syngenta CTL, Macclesfield, United Kingdom.
#378
3:50
EVALUATION OF THE PERFORMANCE OF
CANDIDATE GENES FOR PREDICTING
SKIN SENSITIZATION POTENTIAL. L.
Gildea1, C. A. Ryan1, L. Foertsch1, J. Kennedy1, R.
Dearman2, I. Kimber2 and G. Gerberick1. 1Procter
& Gamble Company, Cincinnati, OH and 2Syngenta
Central Toxicology Laboratory, Macclesfield, United
Kingdom.
MONDAY
45th Annual
Meeting & ToxExpo
#379
4:10
USE OF A MULTIDISCIPLINARY APPROACH
THAT IDENTIFIED PHENOLIC DERMAL
SENSITIZERS IN A WOUND CLOSURE
TAPE. L. P. Myers1, B. F. Law1, A. Fedorowicz1,
G. Sussman2, P. D. Siegel1, B. J. Meade1 and D.
Beezhold1. 1National Institute for Occupational
Safety and Health, Morgantown, WV and
2
Department of Medicine, University of Toronto,
Toronto, ON, Canada.
#384
2:50
RISK ASSESSMENT OF HALOGENATED
PHENOLIC COMPOUNDS AND SOME
BROMINATED FLAME RETARDANTS.
C. Buitenhuis1, A. Bergman2, A. Gutleb1, H.
Lilienthal3, L. Hagmar4, C. Regan5, P. Sauer6,
I. Brandt7, J. Legler1 and A. Brouwer1. 1Vrije
University, Amsterdam, Netherlands, 2Stockholm
University, Stockholm, Sweden, 3BGFA, Klinische
Arbeitsmedizin, Bochum, Germany, 4Lund
University, Lund, Sweden, 5National University
of Ireland, Dublin, Ireland, 6State University
Groningen, Groningen, Netherlands and 7Uppsala
University, Uppsala, Sweden.
#385
3:10
IARC MONOGRAPHS: THE NEW
PREAMBLE. V. J. Cogliano, R. Baan, K. Straif,
Y. Grosse, B. Secretan and F. El Ghissassi.
International Agency for Research on Cancer, Lyon,
France. Sponsor: C. Portier.
#386
3:30
INCORPORATING GENETIC
SUSCEPTIBILITY DATA IN STANDARDSETTING FOR AIR POLLUTANTS. G. E.
Marchant. College of Law, Arizona State University,
Tempe, AZ.
#387
3:50
TRIETHYL PHOSPHATE, TRIPROPYL
PHOSPHATE, AND TRIBUTYL PHOSPHATE:
ORAL RISK ASSESSMENT AND CLASS
BASED EVALUATION LEVEL. N. Berdasco
and D. I. McCready. Toxicology and Environmental
Research and Consulting, The Dow Chemical
Company, Midland, MI.
#388
4:10
CHILDREN’S PESTICIDE EXPOSURE
STUDIES: WHERE DO WE GO FROM
“CHEERS”? R. A. Fenske. Environmmental
Health, University of Washington, Seattle, WA.
Sponsor: T. Kavanagh.
Monday, March 6
1:30 PM to 4:30 PM
Room 1B
PLATFORM SESSION: RISK ASSESSMENT—REGULATORY/
POLICY
Chairperson(s): William Mattes, Gene Logic Inc., Gaithersburg, MD and
Lisa Yost, Exponent, Bellevue, WA.
MONDAY
#380
1:30
MODE OF ACTION AND THE INHALATION
CARCINOGENICITY OF NAPHTHALENE.
L. Flowers1, C. Keshava1 and P. McClure2. 1NCEA,
U.S. EPA, Washington, DC, DC and 2Environmental
Science Center, Syracuse Research Corporation,
Syracuse, NY.
#381
1:50
AGE RELATED DIFFERENCES IN
SUSCEPTIBILITY TO CARCINOGENESIS—A
PRELIMINARY CLASSIFICATION OF
NON-MUTAGENIC MODES OF ACTION TO
STRUCTURE QUANTITATIVE ANALYSIS OF
BIOASSAY DATA. D. Hattis1, M. Chu2, P. Verma1,
N. Rahmioglu1 and R. Goble1. 1George Perkins
Marsh Institute, Clark University, Arlington, MA
and 2National Center for Environmental Assessment,
U.S. EPA, Washington, DC.
#382
#383
2:10
2:30
APPROACHES FOR DERIVING RELATIVE
CARCINOGENIC POTENCY FACTORS FOR
POLYCYCLIC AROMATIC HYDROCARBONS
(PAHS). P. R. McClure1, J. Benedict2, H.
Carlson-Lynch1, M. Gelhaus2, C. Keshava2, J.
Stickney1 and L. Flowers2. 1Syracuse Research
Corporation, Syracuse, NY and 2National Center for
Environmental Assessment, U.S. EPA, Washington,
DC.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: FEMALE REPRODUCTION
Chairperson(s): Srivatcha Naragoni, Southern University A & M, Baton
Rouge, LA.
DETERMINATION OF THE MAGNITUDE
OF INTRASPECIES DIFFERENCES IN
RED BLOOD CELL CHOLINESTERASE
INHIBITION IN RESPONSE TO
DICHLORVOS EXPOSURE. L. M. Plunkett1, T.
B. Starr2, S. H. Youngren3, J. A. MacGregor4 and A.
Manley5. 1Integrative Biostrategies LLC, Houston,
TX, 2TBS Associates, Raleigh, NC, 3The Acta
Group, Washington, DC, 4Toxicology Consulting
Services, Arnold, MD and 5Amvac Chemical
Corporation, Newport Beach, CA.
Displayed: 1:30 PM–4:30 PM
Attended: 1:30 PM–3:00 PM
#389
90
EFFECTS OF 3 WEEK EXPOSURES TO
METAM SODIUM ON REPRODUCTIVE
FUNCTION IN THE FEMALE RAT. A. S. Murr,
R. L. Cooper and J. M. Goldman. Endocrinol. Br.,
RTD, NHEERL, ORD, U.S. EPA, Research Triangle
Park, NC.
45th Annual
Meeting & ToxExpo
#390
#391
#392
THE REPORTED ACTIVE METABOLITE
OF THE PESTICIDE METHOXYCHLOR
(MC), 2, 2-BIS(P-HYDROXYPHENYL)-1, 1,
1-TRICHLOROETHANE (HPTE), INHIBITS
ANDROGEN PRODUCTION BY RAT
OVARIAN THECA INTERSTITIAL (TI)
CELLS. Y. Akgul2, 1, R. C. Derk1 and E. P. Murono1,
2 1
. Pathology and Physiology Research Branch,
NIOSH, Morgantown, WV and 2Department of
Physiology and Pharmacology, West Virginia
University School of Medicine, Morgantown, WV.
Sponsor: V. Castranova.
#397
ANALYSIS OF GENE EXPRESSION IN RAT
OVARIAN FOLLICLES: A COMPARISON
PRIOR TO IN VIVO VS. IN VITRO EXPOSURE
TO 4-VINYLCYCLOHEXENE DIEPOXIDE.
S. M. Fernandez1, J. B. Hoying2, 1 and P. B. Hoyer1.
1
Physiology, University of Arizona, Tucson, AZ and
2
Biomedical Engineering, University of Arizona,
Tucson, AZ.
#398
METHOXYCHLOR AND ITS METABOLITES
INHIBIT GROWTH AND INDUCE ATRESIA
OF ANTRAL FOLLICLES IN BABOON
OVARIES. R. Gupta1, G. Aberdeen2, J. Babus1, E.
Albrecht2 and J. Flaws1. 1Toxicology, University
of Maryland, Baltimore, MD and 2Obstetrics,
Gynecology and Reproductive Sciences, University
of Maryland, Baltimore, MD.
COMPARATIVE TRANSCRIPTIONAL,
MORPHOMETRIC AND UTEROTROPHIC
ASSESSMENT OF ESTROGEN SIGNALLING
IN THE RODENT UTERUS. J. C. Kwekel, L.
D. Burgoon, J. W. Burt, J. R. Harkema and T. R.
Zacharewski. Biochemistry and Molecular Biology,
#399
METHOXYCHLOR INDUCES ATRESIA
OF ANTRAL FOLLICLES IN ER ALPHA
OVEREXPRESSING MICE. D. Tomic1, J. K.
Babus1, S. M. Frech2, R. Gupta1, P. A. Furth2, R.
D. Koos3 and J. A. Flaws1. 1Program in Toxicology,
University of Maryland, Baltimore, MD,
2
Department of Oncology, Lombardi Comprehensive
Cancer Center, Georgetown University, Washington,
DC and 3Department of Physiology, University of
GESTATIONAL PFOA EXPOSURE OF
MICE IS ASSOCIATED WITH ALTERED
MAMMARY GLAND DEVELOPMENT IN
DAMS AND FEMALE OFFSPRING. S. S.
White1, J. L. Rayner2, E. P. Hines3, J. R. Thibodeaux3
and S. E. Fenton3. 1Toxicology, UNC, Chapel Hill,
NC, 2ESE, UNC, Chapel Hill, NC and 3Reproductive
Toxicology Division, NHEERL, ORD, U.S. EPA,
#400
FERTILIZATION RATE AND OOCYTE
QUALITY IS ADVERSELY AFFECTED
FOLLOWING NEONATAL EXPOSURE TO
THE PHYTOESTROGEN GENISTEIN. W. N.
Jefferson1, 3, E. Padilla-Banks1, E. H. Goulding2,
E. M. Eddy2 and R. R. Newbold1. 1Laboratory
of Molecular Toxicology, NIEHS, Research
Triangle Park, NC, 2Laboratory of Reproductive
and Developmental Toxicology, NIEHS, Research
Triangle Park, NC and 3Department of Molecular
and Environmental Toxicology, North Carolina State
#401
EFFECTS OF GESTATIONAL AND
NEONATAL EXPOSURE TO GENISTEIN
ON THE DEVELOPMENTS OF OVARY
AND UTERUS IN PREPUBERTAL RATS. S.
Kim1, R. Lee1, G. Rhee1, S. Kwack1, J. Seok1, K.
Lim1, J. Kang1, J. Chung2, J. Kim2 and D. Cho1.
1
Reproductive & Developmental Toxicology,
National Institute of Toxicological Research, Korea
FDA, Seoul, South Korea and 2Department of
Anatomy and Cell Biology, Dong-A University,
Busan, South Korea. Sponsor: J. Hong.
#402
VALIDATING A GENE EXPRESSION
PROFILE FOR ESTROGENS IN FETAL
UTERUS AND OVARIES: TOWARDS AN
ALTERNATIVE METHOD FOR ENDOCRINE
ASSESSMENT. G. Daston, L. Foertsch, G.
Overmann, S. Torontali, J. Tiesman, G. Carr, T.
Leazer and J. Naciff. Miami Valley Labs, Procter &
Gamble, Cincinnati, OH.
#403
COMPARATIVE ANALYSIS OF TEMPORAL
GENE EXPRESSION, MORPHOMETRY
AND UTEROTROPHY IN TAMOXIFEN AND
ETHYNYLESTRADIOL TREATED RATS. H.
A. Dalgleish, J. C. Kwekel, L. D. Burgoon and T. R.
Zacharewski. Biochemistry and Molecular Biology,
#393
ANTI-MULLERIAN HORMONE
CORRELATES WITH OVARIAN FOLLICLE
POPULATIONS IN MICE. P. J. Devine1 and L.
P. Mayer2. 1Institut Armand-Frappier, INRS, Pointe
Claire, QC, Canada and 2Biological Sciences,
Northern Arizona University, Flagstaff, AZ.
#394
TCDD ALTERS FOLLICULAR
DEVELOPMENT AND STEROIDOGENESIS:
USING THE ZEBRAFISH TO IDENTIFY
THE MOLECULAR TARGETS OF TCDD’S
REPRODUCTIVE TOXICITY. T. King Heiden1,
2
, C. Struble3, M. Hessner4, R. J. Hutz2, 1 and M.
J. Carvan1. 1Great Lakes Water Institute, UWMilwaukee, Milwaukee, WI, 2Department of
Biological Sciences, UW-Milwaukee, Milwaukee,
WI, 3Department of Mathematics, Marquette
University, Milwaukee, WI and 4Department
of Pediatrics, Medical College of Wisconsin,
Milwaukee, WI.
#395
INVESTIGATION OF THE CELL DEATH OF
SMALL PREANTRAL FOLLICLES INDUCED
BY DNA-DAMAGING AGENTS IN CULTURED
MOUSE OVARIES. P. Desmeules and P. J. Devine.
INRS-Institut Armand-Frappier, Montréal, QC,
Canada.
#396
IRRITATION TESTING OF CONTRACEPTIVE
AND FEMININE-CARE PRODUCTS USING
EPIVAGINALTM, AN IN VITRO HUMAN
VAGINAL-ECTOCERVICAL TISSUE MODEL.
S. Ayehunie, J. Kubilus, P. Hayden, C. Cannon,
S. Lamore and M. Klausner. R & D, MatTek
Corporation, Ashland, MA.
91
MONDAY
45th Annual
Meeting & ToxExpo
#404
SCREENING OF PUTATIVE
PHYTOESTROGEN RESPONSIVE GENES
FOR ESTROGEN ACTIVITY. S. Naragoni1,
R. Solipuram1 and W. G. Gray1, 2. 1Environmental
Toxicology, Southern University A & M, Baton
Rouge, LA and 2Department of Chemistry, Southern
University A & M, Baton Rouge, LA.
#409
PROGRESS TOWARD DEVELOPMENT OF
IN VITRO METHODS FOR ASSESSING THE
RELATIVE ORAL BIOAVAILABILITY OF
ARSENIC FROM SOIL. Y. Lowney1, M. V. Ruby1,
L. A. Petersen1 and S. M. Roberts2. 1Exponent, Inc.,
Boulder, CO and 2University of Florida, Gainseville,
FL.
#405
AN ASSESSMENT OF THE EFFECTS
OF GESTATIONAL AND LACTATIONAL
EXPOSURE TO ETHINYL ESTRADIOL
(EE) AND BISPHENOL A (BPA) ON
REPRODUCTIVE MORPHOLOGY AND
BEHAVIOR IN FEMALE AND MALE LONG
EVANS HOODED RAT. B. C. Ryan1, 4, K. L.
Howdeshell2, 4, J. G. Vandenbergh1, K. M. Crofton3
and L. Gray4. 1Zoology, North Carolina State
University, Raleigh, NC, 2Molecular Biosciences,
North Carolina State University, Raleigh, NC,
3
Neurotoxicology, U.S. EPA, Research Triangle
Park, NC and 4Reproductive Toxicology, U.S. EPA,
#410
MEASUREMENT OF THE RELATIVE
BIOAVAILABILITY OF ARSENIC FROM SOIL
IN CYNOMOLGUS MONKEYS. S. M. Roberts1,
J. W. Munson1, Y. W. Lowney2 and M. V. Ruby2.
1
Ctr. Environment Human Toxicology, University
of Florida, Gainesville, FL and 2Exponent, Boulder,
CO.
#411
INORGANIC ARSENITE ALTERS
MACROPHAGE GENERATION FROM
HUMAN PERIPHERAL BLOOD
MONOCYTES; ARSENIC-INDUCED HUMAN
MACROPHAGES (AS-MP). T. Sakurai, C. Kojima
and S. Himeno. Laboratory of Molecular Nutrition
and Toxicology, Faculty of Pharmaceutical Sciences,
Tokushima Bunri University, Tokushima, Japan.
#412
INORGANIC AND METHYLATED
TRIVALENT ARSENICALS SUPPRESS
ADIPOCYTE DIFFERENTIATION. D. S. Paul1,
H. Winter1 and M. Styblo1, 2. 1Nutrition, University
of North Carolina, Chapel Hill, NC and 2CEMLB,
#413
TISSUE DISTRIBUTION OF ARSENIC
SPECIES IN MICE CHRONICALLY EXPOSED
TO ARSENITE OR METHYLARSONOUS
ACID. V. Devesa1, D. S. Paul1, D. J. Thomas2 and M.
Styblo1, 3. 1Nutrition, University of North Carolina at
Chapel Hill, Chapel Hill, NC, 2U.S. EPA, Research
Triangle Park, NC and 3CEMLB, University of
#414
CHARACTERIZATION OF HSF1 AND NRF2
IN THE TRANSCRIPTIONAL RESPONSE
TO ARSENITE. J. F. Reichard and A. Puga.
Cincinnati, OH.
#415
TRIVALENT METHYLATED ARSENICALS
INDUCE PROCOAGULANT ACTIVITY
THROUGH PHOSPHATIDYLSERINE
EXPOSURE IN HUMAN PLATELETS. J.
Chung1, J. Park3, C. Lee2 and O. Bae1. 1College
of Pharmacy, Seoul National University, Seoul,
South Korea, 2Ulsan University Hospital, Ulsan,
South Korea and 3College of Medicine, Chung Ang
University, Seoul, South Korea.
#416
METHYLATION, OXIDATION STATE AND
MEMBRANE PERMEABILITY DETERMINE
TOXICITY OF ARSENIC COMPOUNDS.
E. Dopp1, L. M. Hartmann2, Universtiy of. von
Recklinghausen1, S. Rabieh2, A. V. Hirner2 and
A. W. Rettenmeier1. 1Institute of Hygiene and
Occupational Medicine, University of DuisburgEssen, Essen, NRW, Germany and 2Institute of
Environmental Analysis, University of DuisburgEssen, Essen, NRW, Germany. Sponsor: G. Alink.
#406
MONDAY
RELIABLE ASSAYS FOR DETERMINING
ENDOGENOUS COMPONENTS OF HUMAN
MILK. E. P. Hines1, J. L. Rayner3, R. Barbee1, B.
Heidenfelder2, R. A. Moreland4, A. Valcour4, J. E.
Gallagher2 and S. E. Fenton1. 1ORD/NHEERL,
Reproductive Toxicology Division, U.S. EPA,
Research Triangle Park, NC, 2ORD/NHEERL,
Human Studies Division, U.S. EPA, Chapel Hill,
NC, 3DESE, UNC-Chapel Hill, Chapel Hill, NC and
4
LabCorp, Inc., Burlington, NC.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: ARSENIC TOXICOLOGY
Chairperson(s): Katherine Squibb, University of Maryland, Baltimore,
MD and Monica Nordberg, Karolinska Institutet, Stockholm, Sweden.
#407
DNA REPAIR GENE, ERCC1, EXPRESSION
AND CHRONIC ARSENIC EXPOSURE IN
INNER MONGOLIA. J. Mo1, Y. Xia2, T. Wade3
and J. Mumford3. 1National Research Council,
Washington, DC, 2Inner Mongolia Center for
Endemic Disease Control and Research, Huhhot,
Inner Mongolia, China and 3U.S. EPA, Research
Triangle Park, NC. Sponsor: M. Madden.
#408
ECG QT INTERVAL PROLONGATION AND
CHRONIC ARSENIC EXPOSURE IN INNER
MONGOLIA. J. Mumford1, Y. Xia2, K. Wu2, W.
E. Sanders3, R. Kwok4 and Z. Yang5. 1U.S. EPA,
Research Triangle Park, NC, 2Inner Mongolia Center
for Endemic Disease Control and Research, Huhhot,
Inner Mongolia, China, 3University of North
Carolina Medical School, Chapel Hill, NC, 4RTI
International, Research Triangle Park, NC and 5Ba
Men Anti-epidemic Station, Lin He, Inner Mongolia,
China. Sponsor: M. Madden.
92
45th Annual
Meeting & ToxExpo
#417
P53 SUPPRESSION OF ARSENITE-INDUCED
MITOTIC CATASTROPHE IS MEDIATED
BY P21WAF1/CIP1. B. F. Taylor1, S. C. McNeely1, H. L.
Miller1, M. J. McCabe2 and J. States1. 1Pharmacology
KY and 2Environmental Medicine, University of
#418
ARSENIC: A POTENTIAL
CHEMOTHERAPEUTIC FOR MELANOMA. S.
C. McNeely, B. F. Taylor and J. States. Pharmacology
KY.
#419
THE ROLE OF LXR/RXR HETERODIMERS
IN ARSENIC-INDUCED ATHEROSCLEROSIS.
K. K. Mann, A. S. Padovani, Q. Guo and W. H.
Miller. Lady Davis Institute for Medical Research,
McGill University, Montréal, QC, Canada.
#420
ARSENITE INDUCES S PHASE DELAY IN
U937 CELLS VIA DOWNREGULATION OF
CDC25A PHOSPHATASE. G. M. Lehmann and M.
J. McCabe. Department of Environmental Medicine,
University of Rochester, Rochester, NY.
#421
#422
#423
#424
CHRONIC LOW DOSE AS(III) TOGETHER
WITH CONTINUOUS HIGH GLUCOSE
RESULTS IN A ROS-MEDIATED
STIMULATION OF HYPERGLYCEMIC
STRESS MARKERS IN ISOLATED
ENDOTHELIAL CELLS. M. A. Ihnat1, S. Shakir1,
J. E. Thorpe1, L. A. Warnke1, A. Andrew2 and J. W.
Hamilton2. 1Cell Biology, University Oklahoma
Health Sciences Center, Oklahoma City, OK and
2
Pharmacology/Toxicology, Dartmouth Medical
School, Hanover, NH.
INTERACTION OF ARSENIC WITH WNT/ΒCATENIN PATHWAYS IN HUMAN COLON
CANCER CELLS LINES. R. C. Goytia Acevedo1,
E. R. Abril2 and R. Lantz2. 1Facultad de Medicina,
Gómez Palacio, Durango, Mexico and 2Cell Biology
and Anatomy, University of Arizona, Tucson, AZ.
INITIATION AND PROGRESSION OF
ATHEROSCLEROSIS IN APOE-/- /LDLR-/MICE EXPOSED TO ARSENIC IN DRINKING
WATER. F. E. Pereira, M. C. Schneider, J. D. Coffin
and H. D. Beall. Biomedical and Pharmaceutical
Sciences and Center for Environmental Health
Sciences, The University of Montana, Missoula,
Missoula, MT.
MONOMETHYLARSONOUS ACID
TRANSFORMS HUMAN BLADDER CELLS.
T. G. Bredfeldt1, X. H. Zheng1, G. S. Watts1, E. A.
Mash2 and A. J. Gandolfi1. 1Pharmacology and
Toxicology, University of Arizona, Tucson, AZ and
2
Chemistry, University of Arizona, Tucson, AZ.
93
#425
ARSENITE AND MONOMETHYLARSONOUS
ACID GENERATE OXIDATIVE STRESS
RESPONSE IN HUMAN BLADDER CELL
CULTURE. K. E. Eblin1, D. Cromey2, M. E.
Bowen1, T. G. Bredfeldt1, E. A. Mash3 and A.
J. Gandolfi1. 1Pharmacology and Toxicology,
University of AZ, Tucson, AZ, 2Cell Biology
and Anatomy, University of AZ, Tucson, AZ and
3
Chemistry, University of AZ, Tucson, AZ.
#426
EXPRESSION OF AS3MT ALTERS
TRANSCRIPTIONAL PROFILES IN HUMAN
UROTHELIAL CELLS EXPOSED TO
ARSENITE. S. Hester1, Z. Drobna2, D. Ducharme3,
M. Waalkes4, D. J. Thomas1 and M. Styblo2.
1
Department of Nutrition, University of North
Carolina, Chapel Hill, NC, 2U.S. EPA, Research
Triangle Park, NC, 3NIEHS, Research Triangle Park,
NC and 4NCI at NIEHS, Research Triangle Park,
NC.
#427
ACUTE AND CHRONIC EXPOSURE OF
MONOMETHYLARSONOUS ACID TO
HUMAN BLADDER CELLS INDUCES
CYCLOOXYGENASE-2. A. J. Gandolfi1, T. G.
Bredfeldt2, S. E. Salt1, X. H. Zheng1, N. L. Lane1,
G. S. Watts3, 1 and E. A. Mash2. 1Pharmacology and
Toxicology, University of Arizona, Tucson, AZ,
2
Chemistry, University of Arizona, Tucson, AZ and
3
Arizona Cancer Center, University of Arizona,
Tucson, AZ.
#428
EFFECT OF ARSENITE ON CELL CYCLE
PROGRESSION AND P53 FUNCTIONALITY
IN HUMAN BLADDER CELL LINE, HT1197.
A. Hernandez-Zavala1, 2, E. Cordova3, L. M. Del
Razo1, M. E. Cebrián1 and E. Garrido1. 1Cinvestav,
Mexico D.F., Mexico, 2INSP, Cuernavaca, Mexico
and 3UNAM, Mexico D.F., Mexico.
#429
INTERACTIONS OF ARSENIC WITH HUMAN
PROSTATE PROGENITOR CELLS. E. J. Tokar1,
W. Qu1, M. M. Webber2 and M. P. Waalkes1. 1LCC,
NCI at NIEHS, Research Triangle Park, NC and
2
#430
ALTERED S-ADENOSYLMETHIONINE
METABOLISM AND GLUTATHIONE
PRODUCTION IN THE EARLY STAGES
OF CHRONIC ARSENIC EXPOSURE IN
HUMAN PROSTATE EPITHELIAL CELLS:
IMPLICATIONS IN ARSENIC ADAPTATION.
J. Coppin1, L. Benbrahim-Tallaa1, M. M. Webber2
and M. P. Waalkes1. 1LCC, NCI at NIEHS, Research
Triangle Park, NC and 2Michigan State University,
East Lansing, MI.
#431
UROGENITAL CARCINOGENESIS IN
FEMALE CD1 MICE INDUCED BY IN UTERO
ARSENIC EXPOSURE IS ENHANCED BY
POSTNATAL DIETHYLSTILBESTROL
TREATMENT. M. P. Waalkes1, J. Liu1, J. M.
Ward2, D. A. Powell3 and B. A. Diwan4. 1LCC, NCI
at NIEHS, Research Triangle Park, NC, 2NIAID,
Bethesda, MD, 3NCI at Frederick, Frederick, MD
and 4SAIC at Frederick, NCI at Frederick, Frederick,
MD.
MONDAY
45th Annual
Meeting & ToxExpo
#432
GENE EXPRESSION IN NORMAL HUMAN
KERATINOCYTES MODULATED BY
TRIVALENT ARSENICALS. K. A. Bailey, R. D.
Owen and S. Thai. EPA, Research Triangle Park,
NC. Sponsor: D. Wolf.
#433
DIVERGENT EFFECTS OF VARIOUS
METALS ON HUMAN KERATINOCYTE
HOMEOSTASIS. T. V. Reznikova and R. H.
Rice. Pharmacology and Toxicology, University of
California - Davis, Davis, CA.
MONDAY
#434
ULTRAVIOLET IRRADIATION AND
ARSENITE INDUCE MITOGEN-ACTIVATED
PROTEIN KINASE SIGNALING AND TARGET
PROTEIN ALTERATIONS. K. L. Cooper and
L. G. Hudson. College of Pharmacy, UNMHSC,
Albuquerque, NM.
#435
ARSENITE SYNERGISTICALLY INCREASES
UV-INDUCED OXIDATIVE DNA DAMAGE IN
HUMAN KERATINOCYTE BY INHIBITING
THE ACTIVITY OF PARP-1. W. Ding, L. G.
Hudson and K. Liu. College of Pharmacy, University
of New Mexico, Albuquerque, NM. Sponsor: M.
Walker.
#436
CENTROSOME ABNORMALITY AND
CELL COLONY FORMATION (CELL
TRANSFORMATION) IN HUMAN LUNG
CELLS INDUCED BY ARSENIC. L. Chang1,
W. Liao1, H. Yu2, T. Cheng3 and P. Lin4. 1Division
Environmental Health & Occupational Medicine,
National Health Research Institute, Miaoli County,
Taiwan, 2National Taiwan University, Taipei, Taiwan,
3
Kaohsoung Medical University, Kaohsiung, Taiwan
and 4Chung Shan Medical University, Taichung,
Taiwan.
#437
ENVIRONMENTAL ARSENIC
CONCENTRATIONS ALTER CALCIUM
SIGNALING AND WOUND REPAIR IN LUNG
EPITHELIAL CELLS. S. Boitano1, 2, C. E. Olsen1,
A. Liguori1 and R. Lantz3. 1Arizona Respiratory
Center, University of Arizona, Tucson, AZ,
2
3
Cell Biology and Anatomy, University of Arizona,
Tucson, AZ.
#438
EFFECTS OF CHRONIC LOW LEVEL
ARSENIC EXPOSURE ON IMMORTALIZED
HUMAN LUNG BRONCHIAL EPITHELIAL
CELLS. K. Divine1, S. Bredow1, D. L. Cook1, D.
M. Walker1, V. E. Walker1, J. Nakamura2 and S.
A. Belinsky1. 1Lung Cancer Program, Lovelace
Respiratory Research Institute, Albuquerque, NM,
NM and 2Environmental Sciences and Engineering,
#439
EFFECT OF AN INACTIVATOR OF
GLYCERALDEHYDE-3-PHOSPHATE
DEHYDROGENASE (GAPDH), A
FORTUITOUS ARSENATE REDUCTASE, ON
DISPOSITION OF ARSENATE IN RATS. Z.
Gregus, B. Nemeti and I. Csanaky. Department of
Pharmacology and Pharmacotherapy, University of
Pecs, Pecs, Hungary.
94
#440
METABOLISM OF ARSENITE IN CULTURED
PRIMARY HEPATOCYTES FROM SIX
MAMMALIAN SPECIES. F. S. Walton1, Z.
Drobna1, A. W. Harmon1, D. J. Thomas2 and M.
Styblo1, 3. 1Department of Nutrition, University of
North Carolina, Chapel Hill, NC, 2ETD, NHEERL,
U.S. EPA, Research Triangle Park, NC and
3
CEMALB, University of North Carolina, Chapel
Hill, NC.
#441
ARSENIC STIMULATES PRO-ANGIOGENIC
GENE EXPRESSION AND CHANGES IN
VASCULAR ARCHITECTURE IN THE
LIVER. A. C. Straub1, D. B. Stolz1, L. R. Klei1,
N. V. Soucy2 and A. Barchowsky1. 1Environmental
and Occupational Health, University of Pittsburgh,
Pittsburgh, PA and 2Chemical Institute of Industrial
Toxicology, Research Triangle Park, NC.
#442
IDENTIFICATION OF AN ALTERNATIVELY
SPLICED ISOFORM OF THE HUMAN CYT19
GENE, AN S-ADENOSYL-L-METHIONINE:
AS-METHYLTRANSFERASE. A. J. McNally and
D. S. Barber. Center for Environmental and Human
Toxicology, University of Florida, Gainesville, FL.
#443
SHRNA-MEDIATED SILENCING OF AS3MT
EXPRESSION MODULATES THE CAPACITY
OF HEPG2 CELLS TO METHYLATE
INORGANIC ARSENIC. Z. Drobna1, D. J.
Thomas2 and M. Styblo1, 3. 1Nutrition, University
of North Carolina, Chapel Hill, NC, 2U.S. EPA,
Research Triangle Park, NC and 3CEMLB, Chapel
Hill, NC.
#444
PARENTAL ARSENIC EXPOSURE ALTERS
GENE EXPRESSION IN THE OFFSPRING OF
MUMMICHOGS. H. Gonzalez2, 1 and L. J. Bain1,
2 1
. Biological Sciences, University of Texas at El
Paso, El Paso, TX and 2Environmental Science and
Engineering, University of Texas at El Paso, El Paso,
TX.
#445
EXAMINATION OF ARSENIC-INDUCED
ALTERATIONS IN CELL CYCLE
PROGRESSION AND GLOBAL GENE
EXPRESSION IN P53 TRANSGENIC MOUSE
EMBRYONIC FIBROBLASTS. J. F. Robinson, X.
Yu, E. J. Gribble, S. Hong, E. Kim, J. S. Sidhu and
E. M. Faustman. Environmental and Occupational
Health Sciences, University of Washington, Seattle,
WA.
45th Annual
Meeting & ToxExpo
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
#452
MECHANISM OF INCREASED CELL
DIVISION AND PROTECTION OF MICE
AGAINST S-1, 2-DICHLOROVINYL-LCYSTEINE-INDUCED ACUTE RENAL
FAILURE AND DEATH. M. C. korrapati1, J.
Chilakapati1, E. A. Lock2, J. R. Latendresse3, A.
Warbritton3 and H. M. Mehendale1. 1Toxicology,
ULM, Monroe, LA, 2BMS, LJMU, Liverpool,
United Kingdom and 3NCTR, Jefferson, AR.
#453
EVALUATION OF OXIDATIVE DAMAGE AND
RENAL DISTAL TUBULAR ANTIOXIDANT
ENZYME RESPONSE FOLLOWING
EXPOSURE TO LINDANE. A. L. Piskac and M.
A. Smith. Environmental Science, University of
Texas-Houston School of Public Health, Houston,
TX.
#454
COMPARISON OF ZUCKER OBESE AND
LEAN RATS SUSCEPTIBILITY TO RENAL
TOXICANTS IN VITRO. M. Valentovic, W.
McCumbee and R. G. Morrison. Pharmacology,
Marshall University School of Medicine,
Huntington, WV.
#455
PROTEIN BINDING OF 2’-METHOXYETHYL
(MOE) ANTISENSE OLIGONUCLEOTIDES
(ASO) AND RENAL ACCUMULATION. T. A.
Watanabe, G. Riley, R. S. Geary and A. A. Levin.
ISIS Pharmaceuticals, Inc., Carlsbad, CA.
#456
UPTAKE AND EFFECTS OF ANTISENSE
OLIGONUCLEOTIDES ISIS 141923 AND
107772 IN RENAL PROXIMAL TUBULAR
CELLS. G. R. Kinsey1, S. P. Henry2 and R. G.
Schnellmann1. 1Pharmaceutical Sciences, Medical
University of South Carolina, Charleston, SC and
2
ISIS Pharmaceuticals, Carlsbad, CA.
#457
IDENTIFICATION OF RENAL PAPILLARY
NECROSIS USING AN EIA FOR URINARY
RENAL PAPILLARY ANTIGEN-1 (RPA-1):
A BIOMARKER OF COLLECTING DUCT
PATHOLOGY. A. Roche1, G. Elliott1, C. Kilty1,
M. Shaw1 and F. Falkenberg2. 1Biotrin International,
Dublin, Ireland and 2CIRES GmbH, Dortmund,
Germany. Sponsor: J. McKim III.
#458
PATHOPHYSIOLOGICAL STUDIES ON
CANINE RENAL PAPILLARY NECROSIS
INDUCED BY NEFIRACEATM. Y. Tsuchiya1,
Y. Tominaga2, S. Takada1, K. Yabe1, T. Jindo1,
K. Furuhama1 and K. T. Suzuki3. 1Drug Safety
Research Laboratory, Daiichi Pharmaceutical Co.,
Ltd., Tokyo, Japan, 2Research Technology Center,
Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan
and 3Department of Toxicology and Environmental
Health, Graduate School of Pharmaceutical
Sciences, Chiba University, Chiba, Japan.
#459
DIETARY EFFECTS ON CELL
PROLIFERATION AND APOPTOSIS
IN P-NONYLPHENOL (NP) INDUCED
POLYCYSTIC KIDNEY DISEASE (PKD)
IN MALE SPRAGUE-DAWLEY RATS. S.
M. Cooper1, X. Fu1, L. Muskhelishvili2, J. R.
Latendresse2 and K. B. Delclos1. 1National Center
for Toxicological Research, Jefferson, AR and
2
Toxicologic Pathology Associates, Jefferson, AR.
POSTER SESSION: KIDNEY
Chairperson(s): Brian Cummings, University of Georgia, Athens, GA and
Sue Ford, Saint Johns University, Jamaica, NY.
#446
#447
EVALUATION OF THE 5/6
NEPHRECTOMIZED RAT MODEL OF
RENAL FAILURE AS A MODEL OF
SECONDARY HYPERPARATHYROIDISM.
M. Boyer, D. Farrell, F. Vlasseros, E. Jacquinet,
J. Jolette, C. Banks and S. Y. Smith. Toxicology,
Charles River Laboratories Preclinical Montréal,
Senneville, QC, Canada.
EXPRESSION PROFILES INDUCED BY
RENAL CARCINOGENS IN EKER RATS
COMPARED TO WILDTYP RATS. K. Stemmer1,
H. Ellinger2, T. Lampertsdoerfer1, K. Lotz2, H. Ahr2
and D. R. Dietrich1. 1Environmental and Human
Toxicology, University of Konstanz, Konstanz,
Germany and 2Molecular and Genetic Toxicology,
Bayer Healthcare AG, Wuppertal, Germany.
#448
COMPARATIVE EARLY MOLECULAR
RESPONSES TO CISPLATIN IN HUMAN AND
RAT KIDNEY TUBULE CELLS IN VITRO.
B. A. Fowler1, J. K. Babus2, M. M. Lipsky3 and J.
A. Flaws2. 1ATSDR, Atlanta, GA, 2Epidemiology
and Preventive Medicine, University of Maryland,
Baltimore, MD and 3Pathology, University of
#449
A NOVEL METHOD FOR THE IN SITU
EVALUATION OF PROXIMAL TUBULAR
EPITHELIAL CELL viaBILITY USING
ETHIDIUM HOMODIMER. E. Diamantakos,
J. Edwards, J. D. Peuler, A. R. Carnes, P. C. Lamar
and W. C. Prozialeck. Pharmacology, Midwestern
University, Downers Grove, IL.
#450
TOXICOPROTEOMICS STUDY ON 3-MCPDINDUCED NEPHROTOXICITY IN RATS.
Y. Yum, S. Kim, D. Jang, S. Kim, M. Hwang and
D. Cho. Department of Toxicological Research,
National Institute of Toxicological Research, Seoul,
South Korea. Sponsor: J. Chung.
#451
COMPARISON OF RESPONSE TO CISPLATIN
TREATMENT IN RAT AND PRIMATE
PRECISION CUT RENAL CORTICAL SLICE
CULTURES. A. G. Aslamkhan. Safety Assessment,
Merck & Co., Inc., West Point, PA. Sponsor: N.
Bhandari.
95
MONDAY
45th Annual
Meeting & ToxExpo
#460
MITOCHONDRIAL DYSFUNCTION IN S-(1,
2-DICHLOROVINYL)-L-CYSTEINE (DCVC)INDUCED APOPTOSIS AND NECROSIS IN
HUMAN PROXIMAL TUBULAR CELLS.
L. H. Lash, I. Papanayotou, D. A. Putt and F. Xu.
Pharmacology, Wayne State University Sch. Med.,
Detroit, MI.
#461
MITOCHONDRIAL LOCALIZATION OF
OXYGEN-REGULATED PROTEIN 150
(ORP150). D. Arrington and R. G. Schnellmann.
Pharmaceutical Sciences, MUSC, Charleston, SC.
#462
COMPARISON OF THE NEPHROTOXICITY
OF IMMUNOSUPPRESSIVE DRUGS IN RATS
USING GENE EXPRESSION ANALYSES.
Q. Huang1, T. Auman2, B. Knight1, R. Paules2, K.
Blanchard1 and S. Jayadev1. 1Toxicology and Safety
Assessment, Boehringer Ingelheim, Ridgefield, CT
and 2NIEHS, Research Triangle Park, NC.
MONDAY
#463
12-MONTH DIETARY ETHYLENE GLYCOL
RENAL TOXICITY, CLEARANCE AND
METABOLISM STUDY IN MALE WISTAR
RATS. D. M. Wilson1, W. M. Snellings1, G. C.
Hard2, M. J. Bartels1, R. A. Corley3, C. R. Kirman4
and K. E. Stebbins1. 1Dow Chemical, Midland,
MI, 2Pathologist, Tairua, New Zealand, 3Battelle
NW, Richland, WA and 4The Sapphire Group,
Beachwood, OH.
#464
ALUMINUM CITRATE BLOCKS TOXICITY
OF OXALATE CRYSTALS BY INHIBITING
THEIR BINDING TO PROXIMAL TUBULE
CELLS. C. Guo, M. D. Garcia and K. McMartin.
Pharmacology, Toxicology & Neuroscience, LSU
Health Sciences Center, Shreveport, LA.
#465
TRANSPORT OF ACYCLOVIR BY LLC-PK1
CELLS GROWN ON FILTERS. H. Z. Qui and S.
M. Ford. Toxicology Program, St. John’s University,
Jamaica, NY.
#466
DICLOFENAC INDUCED NEPHROTOXICITY
IN RAT ISOLATED RENAL CORTICAL
CELLS. G. O. Rankin, D. Anestis, L. Waugh and S.
Brown. Pharmacology, Physiology & Toxicology,
Marshall University, Huntington, WV.
#467
OSTEOPONTIN UPREGULATION IS
COMMENSURATE WITH ENHANCED
TISSUE REPAIR AND PROTECTION OF
DIABETIC KIDNEY AGAINST ACUTE RENAL
FAILURE (ARF) AND DEATH INDUCED
BY DCVC. A. V. Dnyanmote1, S. P. Sawant1, E. A.
Lock2, J. R. Latendresse3 and H. M. Mehendale1.
1
Toxicology, ULM, Monroe, LA, 2Biomolecular
Sciences, LJMU, Liverpool, United Kingdom and
3
Toxicologic Pathology, NCTR, Jefferson, AR.
#468
HUMAN ALDEHYDE DEHYDROGENASE 7A1
(ALDH7A1) PROTECTS AGAINST OSMOTIC
STRESS. V. Vasiliou, D. Orlicky, N. Lassen, T. Estey,
A. Pappa, M. Gu and R. Agarwal. Pharmaceutical
Sciences, UCHSC, Denver, CO.
96
#469
POTENTIAL ROLE OF KIDNEY INJURY
MOLECULE-1 IN ENDOTHELIAL CELL
MIGRATION AND ANGIOGENESIS. V. S.
Vaidya1, C. A. Fernandez2, B. D. Humphreys1, H.
Sugimoto3, R. Kalluri3, M. A. Moses2 and J. V.
Bonventre1. 1Medicine-Renal, Brigham and Women’s
Hospital, Harvard Medical School, Boston, MA,
2
Vascular Biology Program, Children’s Hospital,
Boston, MA and 3Center for Matrix Biology, Beth
Israel Deaconess Medical Center, Boston, MA.
#470
NOVEL ROLES FOR CA2+-INDEPENDENT
PHOSPHOLIPASE A2 IN RENAL CELL
GROWTH AND PROLIFERATION. G. Saavedra,
W. Zhang and B. S. Cummings. Pharmacology and
Biomed. Sciences, University of Georgia, Athens,
GA.
#471
EFFECT OF THE NEPHROTOXIC
COMPOUNDS ARISTOLOCHIC ACID (AA),
METHYAZOXYMETHANOL ACETATE
(MAMAC) AND OCHRATOXIN A (OTA) ON
THE CELL CYCLE IN VITRO. S. Huljic1, L.
Helbig2, R. Koehl2, E. OBrien1, B. Bruene2 and D.
R. Dietrich1. 1Environmental Toxicology, University
of Konstanz, Konstanz, Germany and 2Biochemistry
I - Pathobiochemistry, University of Frankfurt,
Frankfurt, Germany.
#472
PROPIVERINE-INDUCED PROTEIN
ACCUMULATION IN F344 RATS: PROTEIN
IDENTIFICATION. A. H. Heussner1, E. O’Brien1,
B. W. Day2, T. Gramatte4, M. Runkel4, S. K. Rumpf3
and D. R. Dietrich1. 1Environmental Toxicology,
University of Konstanz, Konstanz, Germany,
2
University of Pittsburgh, Pittsburgh, PA, 3IPMCTMC, Neuwilen, Switzerland and 4APOGEPHA,
Dresden, Germany.
#473
ACCUMULATION IN F344 RATS.
DEMONSTRATION OF DOSE-DEPENDENCY
AND INTRARENAL LOCALIZATION
OF ACCUMULATED D-AMINO ACID
OXIDASE VIA WESTERN BLOT AND
IMMUNOHISTOCHEMISTRY. T. Gramatte3,
M. Runkel3, A. H. Heussner1, E. O’Brien1, P. Wolf1,
S. K. Rumpf2 and D. R. Dietrich1. 1Environmental
Germany, 2IPMC-TMC, Neuwilen, Switzerland,
3
APOGEPHA, Dresden, Germany and 4University of
Pittsburgh, Pittsburgh, PA.
#474
ACCUMULATION IN F344 RATS. SITESPECIFIC EXCISION AND SUBSEQUENT
IDENTITY CONFIRMATION VIA TANDEM
MASS SPECTROMETRY OF D-AMINO
ACID OXIDASE ACCUMULATED IN RENAL
PROXIMAL TUBULES. B. W. Day4, A. H.
Heussner1, E. O’Brien1, T. Gramatte3, M. Runkel3,
S. K. Rumpf2 and D. R. Dietrich1. 1Environmental
Germany, 2IPMC-TMC, Neuwilen, Switzerland,
3
APOGEPHA, Dresden, Germany and 4University of
45th Annual
Meeting & ToxExpo
#475
CHARACTERIZATION OF RENAL α2UGLOBULIN INDUCTION. D. R. Dietrich1, A. H.
Heussner1, E. O’Brien1, T. Gramatte3, M. Runkel3
and S. K. Rumpf2. 1Environmental Toxicology,
University of Konstanz, Konstanz, Germany, 2IPMCTMC, Neuwilen, Switzerland, 3APOGEPHA,
Dresden, Germany and 4University of Pittsburgh,
Pittsburgh, PA.
#476
REVERSIBILITY OF PATHOLOGICAL
CHANGES AND PROTEIN ACCUMULATION.
M. Runkel3, S. K. Rumpf2, A. H. Heussner1,
E. O’Brien1, T. Gramatte3 and D. R. Dietrich1.
1
Environmental Toxicology, University of Konstanz,
Konstanz, Germany, 2IPMC-TMC, Neuwilen,
Switzerland and 3APOGEPHA, Dresden, Germany.
#477
ASSESSMENT OF CELL PROLIFERATION,
CONCLUSIONS AND HUMAN RISK
ASSESSMENT. E. O’Brien1, M. Runkel3, S. K.
Rumpf2, A. H. Heussner1, T. Gramatte3, B. W. Day4
and D. R. Dietrich1. 1Environmental Toxicology,
University of Konstanz, Konstanz, Germany, 2IPMCTMC, Neuwilen, Switzerland, 3APOGEPHA,
Dresden, Germany and 4University of Pittsburgh,
Pittsburgh, PA.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
#480
GLUCURONIDATION AS A METABOLIC
PATHWAY TERMINATING REDOX
CYCLING OF 9, 10-PHENANTHRAQUINONE
ASSOCIATED WITH OXIDATIVE STRESS.
K. Taguchi and Y. Kumagai. Doctoral Program
in Social and Environmental Medicine, Graduate
School of Comprehensive Human Sciences,
University of Tsukuba, Tsukuba, Japan. Sponsor: A.
Naganuma.
#481
HYPOXIA-INDUCED OXIDATIVE STRESS
RESPONSES IN MACROPHAGES AND
EPITHELIAL CELLS. A. Connor, N. Pierre, J. D.
Laskin, J. P. Gray and D. L. Laskin. Joint Graduate
Program in Toxicology, Rutgers University and
UMDNJ-Robert Wood Johnson Medical School,
Piscataway, NJ.
#482
THE OXIDATIVE EFFECTS OF CIGARETTE
SMOKE ELECTROPHILIC CONSTITUENTS
ON THE MEMBRANE OF A HUMAN LUNG
EPITHELIAL CELL LINE. M. R. Robles1 and J.
Avalos2. 1Soka University of America, Aliso Viejo,
CA and 2TopTox Consulting, Sacramento, CA.
#483
CHEMICAL DEPENDENT
PHOSPHORYLATION OF HEAT SHOCK
PROTEIN 27. J. L. Lord1, Z. Jia1, M. D. Person2, J.
Shen3, T. J. Monks1 and S. S. Lau1. 1Department of
Pharmacology & Toxicology, College of Pharmacy,
University of Arizona, Tucson, AZ, 2Division of
Pharmacology & Toxicology, College of Pharmacy,
University of Texas, Austin, Austin, TX and
3
UTMDACC, Science Park - Research Division,
Smithville, TX.
#484
HYPERGLYCEMIA DECREASES
MITOCHONDRIAL FUNCTION: THE
REGULATORY ROLE OF MITOCHONDRIAL
BIOGENESIS. C. M. Palmeira1, A. P. Rolo1, J.
Berthiaume2, J. A. Bjork2 and K. B. Wallace2. 1Center
for Neurosciences and Cell Biology, Department of
Zoology, University of Coimbra, Coimbra, Portugal
and 2Department of Biochemistry & Molecular
Biology, University of Minnesota Medical School,
Duluth, MN.
#485
CORRELATION OF REACTIVE OXYGEN
SPECIES AND MENADIONE- OR PARAAMINOPHENOL-INDUCED CYTOTOXICITY.
B. D. Foreman and J. B. Tarloff. Pharmaceutical
Sciences, University of the Sciences in Philadelphia,
Philadelphia, PA.
#486
NITROXYL (HNO) INHIBITS CATALASE
AND GLUTATHIONE PEROXIDASE,
BOTH PURIFIED AND IN MACROPHAGE
CELLS, SLOWING THE CATABOLISM OF
HYDROGEN PEROXIDE. M. I. Jackson and J.
M. Fukuto. Molecular Toxicology, University of
California, Los Angeles, Los Angeles, CA. Sponsor:
R. Schiestl.
#487
INSTABILITY OF LACTATE
DEHYDROGENASE ACTIVITY IN THE
PRESENCE OF CHEMICALS. D. M. Kendig and
J. B. Tarloff. Pharmaceutical Sciences, University of
the Sciences in Philadelphia, Philadelphia, PA.
POSTER SESSION: OXIDATIVE INJURY MECHANISMS
Chairperson(s): Joan Tarloff, University of the Sciences, Philadelphia, PA
and Louis Trombetta, Saint Johns University, Jamaica, NY.
#478
INDICES OF ANTIOXIDANT STATUS IN
SHEEP AFTER EXPOSURE TO CHLORINE
GAS. M. A. Dubick, D. G. Cameron, A. I.
Batchinsky and L. C. Cancio. U.S. Army Institute
of Surgical Research, San Antonio, TX. Sponsor: S.
Omaye.
#479
INDUCTION OF OXIDATIVE LUNG INJURY
AND CELLULAR RESPONSES BY DIESEL
EXHAUST PARTICLES IN WILD TYPE AND
INDUCIBLE NITRIC OXIDE SYNTHASEDEFICIENT MICE. J. Y. Ma1, M. Barger1, J.
K. Ma2 and V. Castranova1. 1HELD, NIOSH,
Morgantown, WV and 2School of Pharmacy, WVU,
Morgantown, WV.
97
MONDAY
45th Annual
Meeting & ToxExpo
#488
GENDER DIFFERENCES IN
ACETAMINOPHEN-INDUCED
HEPATOXICITY IN WILD-TYPE AND GCLMNULL MICE. L. McConnachie, I. Mohar and T. J.
Kavanagh. Environmental and Occupational Health
Sciences, University of Washington., Seattle, WA.
#489
TAT-MEDIATED PROTEIN TRANSDUCTION
OF GLUTAMATE CYSTEINE LIGASE INTO
MAMMALIAN CELLS. C. C. Franklin and C.
Brocker. Department of Pharmaceutical Sciences,
University of Colorado Health Sciences Center,
Denver, CO. Sponsor: T. Kavanagh.
#490
MULTIPLEXED FLUORESCENT METHODS
FOR MEASURING PROTEIN/NONPROTEIN
THIOLS IN THE LUNG: APPLICATION TO
THE STUDY OF CYTOTOXIC AROMATIC
HYDROCARBONS. P. Spiess, D. Morin, B.
Boland and A. Buckpitt. Department of Molecular
Biosciences, School of Vet. Med., University of
California - Davis, Davis, CA.
MONDAY
#491
DICHLOROACETATE- AND
TRICHLOROACETATE-INDUCED
PHAGOCYTIC ACTIVATION AND
INDUCTION OF OXIDATIVE STRESS IN THE
HEPATIC TISSUES OF MICE. E. A. Hassoun and
S. Dey. Pharmacology, University of Toledo, Toledo,
OH.
#492
CYCLOSPORINE A-INDUCED OXIDATIVE
STRESS DETECTED BY FLUORESCENCE
PROBES AND DIFFERENTIAL GENE
EXPRESSIONS IN RAT PRIMARY
HEPATOCYTES. H. Fujimura, I. Nakamura, E.
Dekura, Y. Ishizuka, C. Aruga and W. Toriumi.
Exploratory Toxicology & DMPK Research
Laboratories, Tanabe Seiyaku Co., Ltd., Toda,
Saitama, Japan. Sponsor: T. Inoue.
#493
#494
MEASURING OXIDATIVE STRESS AND DNA
DAMAGE IN CELLS USING HIGH CONTENT
SCREENING. C. Vasudevan and J. R. Haskins.
Cellomics, Inc., Pittsburgh, PA. Sponsor: A.
Barchowsky.
CHARACTERIZATION OF THE EFFECTS
OF LIPID ALDEHYDE MODIFICATION
OF PEROXIREDOXIN 6. J. Roede1, D.
Carbone2, J. Doorn3, Z. Kiebler1 and D. Petersen1.
1
Pharmaceutical Sciences, University of
Colorado Health Sciences Center, Denver, CO.,
2
Environmental and Radiological Health Sciences,
Colorado State University, Fort Collins, CO and
3
Medicinal and Natural Products, University of
Iowa, Iowa City, IA.
98
#495
RELEASE OF ZINC BY REACTIVE OXYGEN
SPECIES AND TRAUMATIC BRAIN INJURY
MEASURED USING HIPPOCAMPAL
MICRODIALYSIS AND GRAPHITE
FURNACE ATOMIC ABSORPTION
SPECTROPHOTOMETRY. B. E. Hawkins1, M.
A. Parsley1, V. Ramanujam2, D. S. DeWitt1 and D.
S. Prough1. 1Anesthesiology, University of Texas
Medical Branch, Galveston, TX and 2Preventative
Medicine & Community Health, University of
Texas Medical Branch, Galveston, TX. Sponsor: M.
Moslen.
#496
PROTECTION BY MEMANTINE OF
CARBOFURAN-INDUCED OXIDATIVE
DAMAGE IN BRAIN. R. C. Gupta1, W. Dettbarn2,
M. Aschner2, S. Milatovic2 and D. Milatovic2.
1
Toxicology, Murray State University, Hopkinsville,
KY and 2Vanderbilt University, Nashville, TN.
#497
SILYMARIN PRE-EXPOSURE MODULATES
OXIDATIVE STRESS AND BCL-XL
EXPRESSION IN THE LIVER AND
PREVENTS DOXORUBICIN-INDUCED
APOPTOTIC AND NECROTIC CELL
DEATHS. N. Patel and S. D. Ray. Mol. Toxicology
Prog., Division of Pharma. Scs., Long Island
University, Brooklyn, NY.
#498
AGE-RELATED ALTERATIONS IN
INFLAMMATION-INDUCED NEURONAL
OXIDATIVE DAMAGE. D. Milatovic1, S.
Milatovic1, R. M. Breyer1, M. Aschner1 and T. J.
Montine2. 1Vanderbilt University, Nashville, TN and
2
#499
IDENTIFICATION OF PHOSPHOLIPIDS
TARGETED BY SPECIFIC CA2+INDEPENDENT PHOSPHOLIPASE A2
ISOFORMS DURING OXIDANT-INDUCED
NEURAL CELL DEATH. B. Peterson and B.
S. Cummings. Pharmacology Biomed Sciences,
University of Georgia, Athens, GA.
#500
TISSUE-SPECIFIC DYSFUNCTION INDUCED
BY MENADIONE IN BLOOD VESSELS:
MECHANISMS FOR Universtiy of-SHAPE
DOSE-RESPONSE CURVE. O. Bae, J. Han, K.
Lim, S. Chung and J. Chung. College of Pharmacy,
Seoul National University, Seoul, South Korea.
#501
MOUSE FETAL FIBROBLASTS DERIVED
FROM Gclm(-/-) KNOCKOUT MICE
UNDERGO PREMATURE SENESCENCE
IN CELL CULTURE. Y. Chen, H. G. Shertzer,
D. W. Nebert and T. P. Dalton. Department of
#502
IN VIVO ATTENUATION OF THE
PARKINSONIAN PHENOTYPE BY
INDUCTION OF THE KEAP1-NRF2
PATHWAY. N. C. Burton, T. W. Kensler and T. R.
Guilarte. Environmental Health Sciences, Johns
Hopkins Bloomberg School of Public Health,
Baltimore, MD.
45th Annual
Meeting & ToxExpo
IRON OVERLOAD DAMAGES
MITOCHONDRIAL DNA AND INHIBITS
RESPIRATION IN VIVO AND IN VITRO. X.
Gao, M. Qian, J. Campian and J. Eaton. Brown
Cancer center, University of Louisville, Louisville,
KY.
#504
Gclm(-/-) GENE-TARGETED MICE ARE
RESISTANT TO OZONE-INDUCED ACUTE
LUNG INJURY. E. Johansson, Y. Chen, S. C.
Wesselkamper, G. D. Leikauf and T. P. Dalton.
Department of Environmental Health, University of
Cincinnati Medical Center, Cincinnati, OH.
#505
#506
#507
TRANSFECTION WITH HUMAN GSTA4-4
ENHANCES RESISTANCE TO OXIDATIVE
STRESS AND ACTIVATION OF GROWTH
FACTORS IN VASCULAR SMOOTH MUSCLE
CELLS VIA BAD PATHWAY. S. Dwivedi1, Y.
Yang1, Y. C. Awasthi2 and P. J. Boor1. 1Pathology,
University of Texas Medical Branch, Galveston, TX
and 2Human Biological Chemistry and Genetics,
University of Texas Medical Branch, Galveston, TX.
#509
ADDUCTION KINETICS OF 4-HYDROXY-2NONENAL ON HUMAN SERUM ALBUMIN.
M. E. Szapacs, J. N. Riggins, L. J. Zimmerman and
D. C. Liebler. Biochemistry, Mass Spectrometry
Research Center, Vanderbilt University, Nashville,
TN.
#510
WITHDRAWN
#513
METAL OXIDE NANOPARTICLES PRODUCE
OXIDATIVE STRESS IN CNS MICROGLIA
AND NEURONS. T. Long1, N. Saleh2, T. Phenrat2,
C. Swartz1, J. Parker3, G. V. Lowry2 and B. Veronesi4.
1
Department of Environmental Sciences and
Engineering, UNC, Chapel Hill, NC, 2Civil and
Environmental Engineering, CMU, Pittsburgh,
PA, 3Bioinformatics, Constella Health Sciences,
Research Triangle Park, NC and 4NHEERL, NTD,
Chairperson(s): J. Christopher States, University of Louisville, Louisville,
KY.
ABSENCE OF GST-Π INCREASES
SENSITIVITY OF MALE MICE TO THE
ENVIRONMENTAL ALDEHYDE ACROLEIN.
D. J. Conklin1, A. Bhatnagar1 and R. Prough2.
1
Cardiology, University of Louisville, Louisville,
KY and 2Biochemistry & Molecular Biology,
University of Louisville, Louisville, KY.
#512
POSTER SESSION: GENOTOXICITY/DNA REPAIR
A MODEL SYSTEM TO ASSESS THE
ROLE OF MODULATED GLUTAMATECYSTEINE LIGASE IN TOXICANT
INDUCED OXIDATIVE STRESS. D. Botta,
L. A. McConnachie, C. Fernandez, P. A. Vliet,
C. C. White and T. J. Kavanagh. Environmental
and Occupational Health Sciences, University of
Washington, Seattle, WA.
PROSTAGLANDINS STIMULATE GSH
EFFLUX IN HUMAN EPITHELIAL CELLS.
B. J. Day1, 2, 3, C. T. Kariya1 and E. Min3. 1Molecular
Toxicology, UCHSC, Denver, CO., 2Medicine &
Immunology, UCHSC, Denver, CO and 3Medicine &
Immunology, NJMRC, Denver, CO.
AUTOMATED ANALYSIS OF OXIDATIVE
INJURY IN AN ANIMAL MODEL OF
PARKINSON’S DISEASE. M. E. Cuda1, J. Callio2,
C. Chu2, L. Reuter1, O. Lapets1 and J. R. Haskins1.
1
Cellomics, Inc., Pittsburgh, PA and 2Department
of Pathology, University of Pittsburgh School of
Medicine, Pittsburgh, PA. Sponsor: A. Barchowsky.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
HEPATIC OXIDATIVE STRESS RESPONSE
TO CCL4. T. Sicilia1, R. Alvarez Sanchez2, R.
Haas2, A. Goetschi2, F. Boess2, A. Mally1, A.
Paehler2, W. Dekant1 and W. Voelkel1. 1toxicology,
university of wuerzburg, Wüerzburg, Germany
and 2Pharmaceuticals, F. Hoffmann-La Roche Ltd.,
Basel, Switzerland.
#508
#511
99
#514
MLH1-DEPENDENT RESPONSES TO 2AMINO-1-METHYL-6-PHENYLIMIDAZO
[4, 5-B] PYRIDINE (PHIP), A FOOD-BORNE
CARCINOGEN. S. L. Smith-Roe and A. B.
Buermeyer. Environmental and Molecular
Toxicology, Oregon State University, Corvallis, OR.
#515
MUTAGENIC AND CARCINOGENIC
POTENTIAL OF MENADIONE. C. Cojocel1,
L. Novotny2 and A. Vachalkova3. 1Pharmacology
and Toxicology, Kuwait University, Safat, Kuwait,
2
Pharmaceutical Chemistry, Kuwait University,
Safat, Kuwait and 3Cancer Research Institute, Slovak
Academy of Science, Bratislava, Slovakia.
#516
STUDIES OF CYTOTOXICITY,
GENOTOXICITY AND APOPTOSIS CAUSED
BY C6-C9-ALDEHYDES IN A549 CELLS.
V. H. Mersch-Sundermann, E. Hepfner and T.
Stahl. Department of Indoor and Environmental
Toxicology, University of Giessen, Giessen,
Germany. Sponsor: J. Pauluhn.
#517
IN VIVO GENOTOXIC EFFECT OF
HEXAVALENT CHROMIUM IN RAT
LEUKOCYTES USING COMET ASSAY.
A. K. Patlolla1 and P. B. Tchounwou2. 1Biology/
Environmental Science, Jackson State University,
Jackson State University, MS and 2Biology/
Environmental Science, Jackson State University,
Jackson, MS.
MONDAY
#503
45th Annual
Meeting & ToxExpo
#518
EFFECTS OF SKIN METABOLISM ON THE
GENOTOXIC POTENTIAL OF AROMATIC
AMINES. A. Zeller1, L. Richoz1, C. Goebel2
and S. Pfuhler2. 1TOXICOLOGY, Cosmital SA,
Marly, Switzerland and 2Product Safety, Wella AG,
Darmstadt, Germany. Sponsor: R. Fautz.
#519
CHRONIC EXPOSURE TO LEAD
CHROMATE CAUSES CENTROSOME
AMPLIFICATION AND ANEUPLOIDY IN
HUMAN LUNG CELLS. A. L. Holmes1, 2, S. S.
Wise1, 2, S. J. Sandwick1, 2, W. L. Lingle3 and J. P.
Wise1, 2, 4. 1Wise Laboratory of Environmental and
Genetic Toxicology, University of Southern Maine,
Portland, ME, 2Maine Center for Toxicology and
Environmental Health, University of Southern
Maine, Portland, ME, 3The Tumor Biology Program,
Division of Experimental Pathology, Mayo Clinic
and Foundation, Rochester, MN and 4Department of
Applied Medical Sciences, University of Southern
Maine, Portland, ME.
#520
MONDAY
#521
#522
#523
ARSENITE CO-EXPOSURE DISRUPTS P53MEDIATED RESPONSES TO BPDE INDUCED
DNA DAMAGE IN HUMAN LUNG CELLS. G.
Jiang and J. States. Pharmacology & Toxicology,
CHARACTERIZATION OF DNACYTOKERATIN ADUCTS INDUCED BY
ARSENIC. P. Ramirez, M. Hernandez, N.
Gonzalez, R. Vera and G. Vargas. Facultad de
Estudios Superiores Cuatitlan, UNAM, Cuatitlan,
Mexico. Sponsor: M. Gonsebatt.
INFLUENCE OF SOLVENTS ON AMES II
RESULTS OF DIFFERENT CARBOXYLIC
ACID HALIDES. A. Amberg, K. Braun, H.
Kauffmann, H. Spirkl, I. Stammberger and A.
Czich. Drug Safety Evaluation, Sanofi-Aventis,
Hattersheim, Germany. Sponsor: M. Bonnefoi.
MUTAGENICITY OF BENZYL CHLORIDE IN
THE AMES TEST DEPENDS ON EXPOSURE
CONDITIONS. M. Fall1, 2, H. Haddouk3, J. Morin1,
R. Forster3 and H. M. Lantum4. 1INSERM U644,
Faculte de Medecine, Rouen, France, 2Laboratory
of Toxicology and hydrology, Faculte de Medecine,
University of Dakar, Dakar, Senegal, 3CIT, Evreux,
France and 4African Society for Toxicological
Sciences (ASTS), Rochester, NY.
#524
ABNORMAL PROCESSING OF CHROMIUMDNA ADDUCTS BY MISMATCH REPAIR
PROTEINS ACTIVATES GENOTOXICITY OF
CHROMIUM(VI). A. Zhitkovich, E. Peterson-Roth
and M. Reynolds. Brown University, Providence, RI.
#525
COMPARISON OF DNA ADDUCT
FORMATION IN LIVER FROM INFANT
B6C3F1 MALE MICE TREATED WITH
BENZO(A)PYRENE AND A RECONSTITUTED
PAH MIXTURE. T. D. Phillips, M. R. Smith, R.
A. Lingenfelter, C. Naspinski, L. Cizmas, A. M.
Gillespie, Z. S. Naufal, G. Zhou, T. J. McDonald
and K. C. Donnelly. Texas A&M University, College
Station, TX.
100
#526
POLYMORPHISMS IN BRCA2 AND WRN,
GENOMIC INSTABILITY AND BENZENE
HEMATOTOXICITY. N. Galvan1, M. Shen2,
Q. Lan2, L. Zhang1, S. Chanock2, G. Li4, R.
Vermeulen2, W. Guo1, A. J. Grosovsky4, S. Yin3, M.
Yeager2, R. Welch2, M. T. Smith1 and N. Rothman2.
1
School of Public Health, University of California,
Berkeley, CA, 2Division of Cancer Epidemiology
and Genetics, NCI, NIH, DHHS, Bethesda, MD,
3
Chinese CDC, Beijing, China and 4Department
of Cell Biology and Neuroscience, University of
California, Riverside, CA.
#527
MUTAGENESIS INDUCED BY TWELVE
QUINOLONE ANTIBACTERIAL AGENTS IN
ESCHERICHIA COLI WP2UVRA/PKM101. Y.
Hayasaki, S. Itoh, M. Kato and K. Furuhama. Drug
safety research laboratory, Daiichi Pharmaceutical
Co., Ltd., Tokyo, Japan.
#528
EFFECTS OF SIDE STREAM TOBACCO
SMOKE ON DNA DELETIONS. R. Reliene, M.
L. Yamamoto, E. Labashinsky-Heinrich and R. H.
Schiestl. UCLA, Los Angeles, CA.
#529
GENOTOXICITY OF CIGARETTE
SMOKE COLLECTED UNDER VARIOUS
CONDITIONS. H. E. Minton, C. Gowdy, S. Millett,
F. Sheabar and G. Holloway. Arista Laboratories,
Inc., Richmond, VA.
#530
NITRIC OXIDE AND REACTIVE OXYGEN
SPECIES MUTAGENESIS OF SUPF GENE
IN AD293 CELLS CO-CULTIVATED WITH
ACTIVATED MACROPHAGES. M. Kim and
G. N. Wogan. Biological Engineering Division,
Massachusetts Institute of Technology, Cambridge,
MA.
#531
THE EFFECT OF NITRIC OXIDE ON THE
MUTAGENICITY AND CYTOTOXICITY OF
CIGARETTE SMOKE CONDENSATE. R. D.
Leverette, M. B. Bennett, J. T. Hamm and S. F. Yee.
Lorillard Tobacco Company, Greensboro, NC.
#532
ROLE OF OXIDATIVE AND NONOXIDATIVE DNA LESIONS IN TOXICITY
OF CHROMIUM(VI). M. F. Reynolds and A.
Zhitkovich. Department of Pathology and Laboratory
Medicine, Brown University, Providence, RI.
#533
OXIDATIVE DNA DAMAGE AND REPAIR IN
PMNC OF SCLERODERMA AND SYSTEMIC
LUPUS ERYTHEMATOSUS. M. Gulumian1,
2
, X. Masoka1 and M. Tikly3. 1Toxicology, NIOH,
Johannesburg, South Africa, 2Haematology and
Molecular Medicine, Wits, Johannesburg, South
Africa and 3Medicine, Wits, Johannesburg, South
Africa. Sponsor: M. Karol.
#534
DETECTION OF OXIDATIVE DAMAGE
IN NEURONAL CELLS CULTURES IN
MICROTITER FORMAT. C. G. Kilty1, M. Shaw1,
S. M. Thomas2 and T. M. Benn3. 1Biomarkers,
Biotrin International, Dublin, Ireland, 2Research
and Enterprise Development, University of Bristol,
Bristol, United Kingdom and 3Institute of Clinical
Neurosciences, University of Bristol, Bristol, United
Kingdom. Sponsor: R. Dixit.
45th Annual
Meeting & ToxExpo
#535
#536
#537
9, 10-PHENANTHRENEQUINONE (9, 10-PQ)
INDUCES DNA DELETIONS VIA OXIDATIVE
AND NON-OXIDATIVE MECHANISMS IN
THE YEAST S. CEREVISIAE. C. Rodriguez1,
Z. Sobol2, A. Cho1, J. Fukuto1 and R. Schiestl2.
1
Pharmacology, David Geffen School of Medicine
at UCLA, Los Angeles, CA and 2Pathology, David
Geffen School of Medicine at UCLA, Los Angeles,
CA.
THE MOUSE LYMPHOMA ASSAY DETECTS
RECOMBINATION, DELETION AND
ANEUPLOIDY. J. Wang1, 2, J. R. Sawyer3, M.
Honma4 and M. M. Moore1. 1DGRT, NCTR,
Jefferson, AR, 2Department of Pharmacology and
Toxicology, University of Arkansas for Medical
Sciences, Little Rock, AR, 3Department of
Pathology, University of Arkansas for Medical
Sciences, Little Rock, AR and 4Division of Genetics
and Mutagenesis, National Institute of Health
Sciences, Tokyo, Japan.
HNO INDUCES DNA DELETIONS IN THE
YEAST S. CEREVISIAE. N. Cook1, Z. Sobol2,
J. Fukuto1 and R. H. Schiestl2. 1Pathology, David
Geffen School of Medicine at UCLA, Los Angles,
CA and 2Pharmacology, David Geffen School of
Medicine at UCLA, Los Angeles, CA.
#538
IONIZING RADIATION AND RESTRICTION
ENZYMES INDUCE MICROHOMOLOGYMEDIATED ILLEGITIMATE
RECOMBINATION IN TRANS IN YEAST. C.
Y. Chan, M. Kiechle, P. Manivasakam and R. H.
Schiestl. Pathology, UCLA, Los Angeles, CA.
#539
RESEARCH ON CHROMOSOMAL
ABERRATIONS IN HUMAN SPERM AND
LYMPHOCYTES EXPOSED TO LARGE-DOSE
IRRADIATION. Y. Lu, B. Fu, Y. Chen and L.
Han. Toxicology, Henan Institute of Occupational
Medicine, Zhengzhou, Henan, China. Sponsor: Y.
Wu.
#540
THE ANTIRETROVIRAL ZIDOVUDINE
ALTERS THE CELL CYCLE AND INDUCES
METABOLIC RESISTANCE IN HUMAN
LYMPHOBLASTOID CELLS EXPOSED
LONG-TERM IN VITRO. O. Olivero, J. M. Ming,
I. L. Vazquez, E. J. Robinson and M. C. Poirier.
National Cancer Institute, Bethesda, MD.
#541
A LOW DNA REPAIR CAPACITY IS
ASSOCIATED WITH NON-MELANOMA SKIN
CANCER TUMORS IN SUN-PROTECTED
AREAS OF THE BODY. J. L. Matta1, J.
Ramos1, A. Ruiz1, J. Villa2 and R. Armstrong3.
1
Pharmacology, Physiology & Toxicology, Ponce
School of Medicine, Ponce, USA, Puerto Rico,
2
Parras Building, Damas Hospital, Ponce, USA,
Puerto Rico and 3Marine Sciences, University of
Puerto Rico, Mayaguez Campus, Mayaguez, USA,
Puerto Rico.
101
#542
REPAIR OF 4-(METHYLNITROSAMINO)-1(3-PYRIDYL)-1-BUTANONE(NNK)–INDUCED
PYRIDYLOXOBUTYLATION BY
NUCLEOTIDE EXICISION REPAIR(NER).
P. J. Brown, L. L. Bedard and T. E. Massey.
Pharmacology and Toxicology, Queen, Kingston,
ON, Canada.
#543
VARIATION IN BIOLOGICAL EFFECTS
OF EXPOSURE TO DIFFERENT
NANOPARTICLES. M. R. Gwinn, S. S. Leonard
and V. Vallyathan. Pathology and Physiology
Research Branch, Health Effects Laboratory
Division, National Institute for Occupational Safety
& Health, Morgantown, WV.
#544
ATM AND MRE11 ARE INVOLVED IN THE
REPAIR OF PARTICULATE CHROMIUM (VI)
–INDUCED DNA DOUBLE STRAND BREAKS.
H. Xie1, 2, S. Dako3, S. S. Wise1, 2, S. P. Katsifis3 and
J. P. Wise1, 2. 1Wise Laboratory of Environmental
and Genetic Toxicology, University of Southern
Maine, Portland, ME, 2Maine Center for Toxicology
and Environmental Health, University of Southern
Maine, Portland, ME and 3Department of Biology,
University of Bridgeport, Bridgeport, CT.
#545
PARTICULATE CHROMIUM INDUCED
DNA-DNA CROSSLINKS LEAD TO
CHROMOSOME DAMAGE. L. C. Savery1, 2, S.
S. Wise1, 2 and J. P. Wise1, 2, 3. 1Wise Laboratory of
Environmental and Genetic Toxicology, University
of Southern Maine, Portland, ME, 2Maine Center for
Toxicology and Environmental Health, University of
Southern Maine, Portland, ME and 3Department of
Applied Medical Sciences, University of Southern
Maine, Portland, ME.
#546
DOSE-RESPONSE COMPARISON OF
MICRONUCLEATED RETICULOCYTE
FREQUENCIES IN RODENT PERIPHERAL
BLOOD WITH FOUR GENOTOXIC AGENTS
BY FLOW CYTOMETRY AND SLIDE-BASED
ENUMERATION. L. Recio1, W. Caspary2, D.
Tourous4, E. Livanos1, G. Kissling3 and K. Witt2.
1
Genetic Toxicology, ILS, Research Triangle Park,
NC, 2Environmental Toxicology Program, NIEHS,
Research Triangle Park, NC, 3Biostatistics Branch,
NIEHS, Research Triangle Park, NC and 4Litron
Laboratories, Rochester, NY.
#547
EFFECTS OF FEEDER CELLS ON THE
COLONY GROWTH AND MORPHOLOGICAL
TRANSFORMATION IN THE SHE CELL
TRANSFORMATION ASSAY. Y. Xu, N. Gibson,
F. Luo, G. Borneo and T. E. Lawlor. Genetic &
Molecular Toxicology, Covance Laboratories,
Vienna, VA.
#548
IDENTIFICATION OF GENE EXPRESSION
SIGNATURE AND A NOVEL MARKER,
DOG1, FOR GENOTOXICITY BY GENE
EXPRESSION PROFILING. J. Hu, D. Aud, K.
Chakravarty, S. Fu, J. Wang, J. Allard, G. Liao, J.
Usuka, K. Dolim, Z. Zhang and G. Peltz. Genentics
& Genomics, Roche Palo Alto, Palo Alto, CA.
MONDAY
45th Annual
Meeting & ToxExpo
#549
EFFECTS OF HUMAN MUTANT WERNER
PROTEIN EXPRESSION ON DNA
DELETIONS IN MICE. M. L. Yamamoto1, R.
Reliene1, J. Oshima2 and R. Schiestl1. 1Pathology,
University of California, Los Angeles, Los Angeles,
CA and 2Pathology, University of Washington,
Seattle, WA.
#550
LACK OF MUTAGENIC AND CLASTOGENIC
ACTIVITY OF COMBRETASTATIN A-4
(CA4)–A MICROTUBULE DESTABILIZING
AGENT. D. N. Sadhu1, L. Desai1, S. Young2, N. W.
Hurst2 and J. C. Randall2. 1Toxikon Corporation,
Bedford, MA and 2OXiGENE, Waltham, MA.
#551
#552
MONDAY
#553
STUDIES ON THE CHEMOPREVENTIVE
EFFECT OF ERUCA SATIVA (RUCOLA) AND
ITS ISOTHIOCYANATES IN HUMAN CELL
CULTURES. E. Lamy, J. F. Schroeder, Y. Voelkel
and V. H. Mersch-Sundermann. Department of
Indoor and Environmental Toxicology, University of
Giessen, Giessen, Germany. Sponsor: J. Pauluhn (?).
DNA DAMAGE INDUCED BY BREVETOXIN
2 IN HUMAN LYMPHOCYTES FROM FIVE
VOLUNTEERS. R. N. Murrell4, 1, A. J. Bourdelais2,
D. G. Baden2, 3 and J. E. Gibson1, 4. 1Pharmacology
and Toxicology, The Brody School of Medicine,
East Carolina University, Greenville, NC, 2Center
for Marine Science, University of North Carolina
at Wilmington, Wilmington, NC, 3Chemistry,
University of North Carolina at Wilmington,
Wilmington, NC and 4Environmental and Molecular
Toxicology, North Carolina State University,
Raleigh, NC.
EARLY TOXICOLOGICAL
CHARACTERIZATION AND
CLASSIFICATION OF CANDIDATE
COMPOUNDS IN A HIGH THROUGHPUT
FORMAT USING NEURAL NETWORKS,
GENE EXPRESSION ANALYSIS, AND AN
IN VITRO CELL PLATFORM SESSION:
GENOTOXIC?, NON-GENOTOXIC?, OR
NON-CARCINOGENIC? G. Vansant1, P. Pezzoli1,
A. Birch1, J. Bibay1, G. Fogel2 and J. Monforte1.
1
eXpress Profiling, Althea Technologies, Inc., San
Diego, CA and 2Evolutionary Computation, Natural
Selection Inc., San Diego, CA.
#556
INFLUENCE OF NON-CHEMICALLY
INDUCED HYPOTHERMIA ON
SUBHYPOTHERMIC DOSES OF PHENOL
IN THE FORMATION OF MICRONUCLEI
(MN) IN THE MOUSE BONE MARROW. B.
Gollapudi, P. J. Spencer, J. M. Grundy and J. M.
Waechter. Toxicology & Environmental Research
and Consulting, The Dow Chemical Company,
Midland, MI.
#557
THE EFFECT OF CIGARETTE PAPER
POROSITY ON CIGARETTE SMOKE
CONDENSATE-INDUCED MICRONUCLEI IN
VITRO. S. V. Vulimiri, R. D. Leverette, G. Jun and
S. F. Yee. A.W. Spears Research Center, Lorillard
Tobacco Company, Greensboro, NC.
#558
VALIDATION OF A NON-RADIOACTIVE
FLOW CYTOMETRY-BASED UNSCHEDULED
DNA SYNTHESIS (FL-UDS) ASSAY. C. A. Kirk,
M. K. Reeder and G. L. DeGeorge. MB Research
Labs, Spinnerstown, PA.
#559
EVALUATION OF A NOVEL MICRONUCLEUS
ASSAY USING A HUMAN 3-D SKIN MODEL,
EPIDERMTM R. D. Curren1, M. Aardema2, P. J.
Hayden3, G. Mun1, T. Hu2, N. Wilt1 and D. Gibson2.
1
Institute for In Vitro Sciences, Inc., Gaithersburg,
MD, 2Procter & Gamble Co., Cincinnati, OH and
3
MatTek Corporation, Ashland, MA.
#560
VITOTOXTM ASSAY DETECTS CHEMICALS
WITH A WIDE RANGE OF GENOTOXIC
MECHANISMS. C. A. Hendricks1, J. Aubrecht2 and
K. Lam1. 1Pfizer Global Research and Development,
Cambridge, MA and 2Pfizer Worldwide Safety
Sciences, Groton, CT.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: TOXICOKINETICS/PHARMACOKINETICS
Chairperson(s): Gunda Reddy, U.S. Army, Aberdeen Proving Ground, MD.
#554
TOXICOGENOMICS OF ENDEMIC
NEPHROPATHY IN CROATIA. A. P. Grollman1,
J. J. Chen1, B. Jelakovic3, N. Leko2, Z. Medverec2, C.
R. Iden1 and S. Shibutani1. 1State University of New
York at Stony Brook, Stony Brook, NY, 2General
Hospital Dr.Josip Bencevic, Slavonski Brod, Croatia
and 3School of Medicine, University of Zagreb,
Zagreb, Croatia.
#555
INFLUENCE OF IMPURITIES ON
GENOTOXICITY FINDINGS OF A DRUG
CANDIDATE – A CASE STUDY. S. G. Sawant1, R.
T. Dunn1, H. Murli2, G. L. Erexson2, V. O. Wagner3,
K. Nam1, T. Day1, C. A. Afshari1, M. Cosenza1
and T. D. Marque1. 1Toxicology, Amgen Inc.,
Thousand Oaks, CA, 2Covance Inc., Vienna, VA and
3
BioReliance Corp., Rockville, MD.
102
#561
AN INTEGRATED TOXICOKINETIC MODEL
FOR ESTIMATING CHILDHOOD BODY
BURDENS OF DIOXINS BASED ON VARIOUS
STUDIES. H. Leung2, B. D. Kerger1, P. Scott3 and
D. J. Paustenbach4. 1HSRI, Inc., Tallahassee, FL,
2
Consultant, Danbury, CT, 3ChemRisk, Pittsburgh,
PA and 4ChemRisk, San Francisco, CA.
#562
DEVELOPMENTAL AGE EFFECTS ON
TISSUE DISPOSITION OF BDE 47 IN MICE.
J. J. Diliberto1, D. F. Staskal2 and L. S. Birnbaum1.
1
NHEERL ORD, U.S. EPA, Research Triangle Park,
NC and 2Curriculum in Toxicology, University of
45th Annual
Meeting & ToxExpo
#563
CHANGES IN MOUSE RENAL
TRANSPORTER EXPRESSION IN RESPONSE
TO ACETAMINOPHEN. M. E. Blake-Kinnin1,
L. M. Aleksunes1, L. Augustine2, N. J. Cherrington2
and J. E. Manautou1. 1Department of Pharmacology
Sciences., University of Connecticut, Storrs, CT
and 2Department of Pharmacology and Toxicology,
#564
ENDOCRINE REGULATION OF GENDER
DIVERGENT EXPRESSION OF MOUSE
ORGANIC ANION TRANSPORTING
POLYPEPTIDES (OATPS). X. Cheng, J. Maher,
H. Lu and C. D. Klaassen. Pharmacology &
Toxicology, KUMC, Kansas City, KS.
#565
#566
TOXICOKINETICS OF P-OCTYLPHENOL
IN MALE AND FEMALE SPRAGUE-DAWLEY
RATS. G. Hamelin, K. Krishnan and R. Tardif.
Occupational and Environmental Health, University
of Montréal, Montréal, QC, Canada.
DISPOSITION AND ELIMINATION
OF TUNGSTEN AFTER ORAL AND
INTRAVENOUS EXPOSURES. R. Marr1, R.
Arimoto2 and J. McDonald1. 1Toxicology, Lovelace
Respiratory Research Institute, Albuquerque, NM
and 2Chemistry, CEMRC, Carlsbad, NM.
#567
COMPARATIVE DISPOSITION OF N, NDIMETHYL-p-TOLUIDINE (DMPT) IN MALE
AND FEMALE FISCHER 344 RATS AND
B6C3F1 MICE. K. J. Dix, K. Ghanbari and B.
M. Hedtke-Weber. Lovelace Respiratory Research
Institute, Albuquerque, NM.
#568
DETERMINATION OF ACESULFAME-K
CONCENTRATIONS AND PRELIMINARY
PHARMACOKINETICS IN C57BL MOUSE
PLASMA AND URINE. J. Lodge1, B. Fletcher1,
D. Brine1, J. Pittmen1, C. Harris1, S. Cooper1,
S. Anderson1, B. Collins2 and C. Garner1. 1RTI
International, Research Triangle Park, NC and
2
National Institute of Environmental Health
Sciences, Research Triangle Park, NC.
#569
OXIDATIVE AND HYDROLYTIC
METABOLISM OF TYPE I PYRETHROIDS
IN RAT LIVER MICROSOMES. E. J. Scollon1,
J. M. Starr2, M. F. Hughes1 and M. J. Devito1. 1ORD/
NHEERL/ETD, U.S. EPA, Research Triangle Park,
NC and 2ORD/NERL/ETD, U.S. EPA, Research
Triangle Park, NC.
#570
IMPLICATIONS OF AGE-DEPENDENT HALF
LIVES OF DIOXINS ON ASSESSMENT OF
BREAST MILK DOSE AND BODY BURDEN.
R. O. Richter2, B. D. Kerger1, H. Leung4 and D.
J. Paustenbach3. 1HSRI, Inc., Tallahassee, FL,
2
Exponent, Irvine, CA, 3ChemRisk, San Francisco,
CA and 4Consultant, Danbury, CT.
#571
THE PHARMACOKINETICS OF DEET IN
THE MOUSE. W. McGuinn1, M. Peden-Adams2,
J. EuDaly2, G. Gilkeson2 and D. Keil3. 1U.S. FDA,
Silver Spring, MD, 2MUSC, Charleston, SC and
3
UNLV, Las Vegas, NV.
103
#572
AGE- AND DOSE-DEPENDENT TISSUE
DISTRIBUTION OF DELTAMETHRIN (DLM)
IN MALE SPRAGUE-DAWLEY (S-D) RATS. K.
Kim1, 2, J. V. Bruckner1 and H. Kim1. 1Department of
Pharmaceutical and Biomedical Sciences, University
of Georgia, Athens, GA and 2Pharmacology
Department, National Institute of Toxicological
Research, Korea Food and Drug Administration,
Seoul, South Korea.
#573
EFFECTS OF
PERFLUOROOCTANESULFONATE ON 125I
ELIMINATION IN RATS AFTER A SINGLE
INTRAVENOUS DOSE OF 125I-LABELED
THYROXINE. S. Tanaka1, M. Eastvold2, E.
Foshay1, J. Hart1 and J. Butenhoff1. 13M Company,
St. Paul, MN and 2Mayo Medical Laboratories,
Rochester, MN.
#574
ACCUMULATION OF NEUROTOXIC
METABOLITES OF 3, 4-(±) METHYLENEDI
OXYMETHAMPHETAMINE IN RAT BRAIN
FOLLOWING MULTIPLE DOSING. G. V.
Erives, S. S. Lau and T. J. Monks. Pharmacology and
Toxicology, University of Arizona Health Science
Center, Tucson, AZ.
#575
BRAIN METABOLISM OF ACRYLONITRILE
TO CYANIDE: IN VITRO STUDIES. O. S.
El-Tawil1, A. M. Mohamadin2, A. B. AbdelNaim3 and A. H. Abou-Hadeed4. 1Department of
Toxicology and Forensic Medicine, Faculty of
Veterinary Medicine, Cairo University, Cairo,
Egypt, 2Tumor Marker Oncology Research Unit,
Department of Biochemistry, Faculty of Pharmacy,
Al-Azhar University, Cairo, Egypt, 3Department
of Pharmacology and Toxicology, Faculty of
Pharmacy, Ain Shams University, Cairo, Egypt and
4
Department of Forensic Medicine and Toxicology,
Faculty of Veterinary Medicine, Zagazig University,
Zagazig, Egypt.
#576
EVALUATION OF PERFLUOROOCTANE
SULFONATE IN THE RAT BRAIN. C. Lau1, J. R.
Thibodeaux1, K. Das1, D. J. Ehresman2, S. Tanaka2,
J. Froehlich3 and J. L. Butenhoff2. 1Reproductive
Research Triangle Park, NC, 2Medical Department,
3M Company, St. Paul, MN and 3Department of
Chemistry, University of California, Davis, CA.
#577
AHR MEDIATED HEMATOTOXICITY IS
INDUCED AT THE SITE OF BONE MARROW
WHERE CONSEQUENT CYP2E1-DERIVED
BENZENE METABOLITES LOCALLY
INDUCE THEIR TOXICITY. Y. Hirabayashi1,
B. Yoon1, G. Li1, Y. Fujii-Kuriyama2, T. Kaneko1,
J. Kanno1 and T. Inoue3. 1Cell & Mol Toxicology
Division, NIHS, Tokyo, Japan, 2TARA, University of
Tsukuba, Tukuba, Japan and 3CBSR, NIHS, Tokyo,
Japan.
#578
TOXICOKINETIC - TOXICODYNAMIC
RELATIONSHIPS IN CASES OF FIPRONIL
EXPOSITION. A. Anadon, M. R. MartinezLarranaga, M. A. Martinez, V. Caballero, M. J. Diaz,
M. Martinez and R. Pita. Department of Toxicology
and Pharmacology, Faculty of Veterinary Medicine,
Complutense University, Madrid, Spain.
MONDAY
45th Annual
Meeting & ToxExpo
#579
PREVENTING THE CONTAMINATION
OF CONTROL SAMPLES BY TEST
ARTICLE DURING TOXICOKINETIC
INVESTIGATIONS. H. Devine. Toxicology,
Senneville, QC, Canada. Sponsor: C. Banks.
#580
MINIMALIST SAMPLING STRATEGIES FOR
TOXICOKINETICS: A RETROSPECTIVE
ANALYSIS. D. M. Grant, L. Kendall, D. Schnell, C.
Langer and K. Lee. Pfizer, Inc., Groton, CT.
#581
#582
MONDAY
#583
#584
#585
#586
#587
DISTRIBUTION OF ANTICANCER DRUGS
INTO TUMOURS AN ASSESSMENT
USING QUANTITATIVE WHOLE-BODY
AUTORADIOGRAPHY. C. Henson, A. Lathall, H.
Bird, A. B. McEwen and S. G. Wood. BioDynamics
Research Limited, Rushden, United Kingdom.
Sponsor: R. Harling.
#588
INFLUENCE OF THE ROUTE OF
ADMINISTRATION OF THE ENANTIOMERIC
FRACTION OF PCB 136 IN MALE C57BL/6
MICE. I. Korwel, N. Shaikh, K. C. Hornbuckle, L.
W. Robertson and H. Lehmler. University of Iowa,
Iowa City, IA.
#589
DISPOSITION OF 14CHEXAMETHYLDISILOXANE (14C-HMDS)
IN MALE FISCHER 344 RATS FOLLOWING
SINGLE AND REPEATED INHALATION
EXPOSURE. J. Durham, D. McNett, J. Tobin, S.
Crofoot and K. Plotzke. Health and Enviromental
Sciences, Dow Corning Corporation, Midland, MI.
#590
METABOLISM AND DOSIMETRY OF
VINCLOZOLIN IN RAT. A. Sierra-Santoyo1, R.
Harrison2, B. C. Edwards2, H. A. Barton2 and M. F.
Hughes2. 1Toxicology, CINVESTAV-IPN, Mexico
City, D.F., Mexico and 2PKB, U.S. EPA, ORD,
NHEERL and NCCT, Research Triangle Park, NC.
#591
COMPARATIVE RAT AND MOUSE IN
VITRO METABOLISM OF 1, 4-DIOXANE.
A. D. Woodstock1, C. M. Carosino1, H. Wu1, K. D.
Thrall1, J. J. Soelberg1, B. J. Locey2, R. J. Clarkson2,
S. Sager2, R. A. Corley1 and T. S. Poet1. 1Battelle,
Pacific Northwest Division, Richland, WA and
2
Arcadis G&M of Michigan, LLC, Southfield, MI.
COMPARISON OF DERMAL UPTAKE
DATA FOR PHARMACOKINETIC MODEL
DEVELOPMENT IN RATS. R. A. Gies, P. M.
Hinderliter, A. D. Woodstock and K. D. Thrall.
Biological Monitoring and Modeling, Pacific
Northwest National Laboratory, Richland, WA.
#592
PLACENTAL TRANSPORT OF BREVETOXIN
IN MICE. J. Benson1, A. Gómez1, G. Statom1,
B. Tibbetts1, L. Backer2, D. Baden3 and A.
Reich4. 1Lovelace Respiratory Research Institute,
Albuquerque, NM, 2CDC, Atlanta, GA, 3University
of North Carolina, Wilmington, NC and 4Florida
Department of Health, Tallahassee, FL.
DISPOSITION AND EXCRETION OF
TETRABROMOBISPHENOL A BIS[2, 3DIBROMOPROPYL ETHER] (TBBPA-DBPE)
IN MALE FISCHER-344 RATS. G. A. Knudsen,
R. K. Kuester, V. P. Rodriguez, A. M. Solyom and
I. Sipes. Pharmacology, College of Medicine, The
#593
DISPOSITION OF
TETRABROMOBISPHENOL A (TBBPA) IN
MALE FISCHER-344 RATS. A. M. Solyom, R. K.
Kuester, V. P. Rodriguez, L. Jacobs, C. J. Sweet and
I. Sipes. Pharmacology, College of Medicine, The
#594
PRELIMINARY TOXICOKINETIC
STUDY AND ANALYTICAL METHOD
DEVELOPMENT FOR BETA-MYRCENE IN
RAT PLASMA. P. J. Schebler1, R. L. Mathias1,
Y. A. Shan1, D. C. Messer1, A. B. Astroff1, A.
P. Clark1, R. K. Harris1, J. W. Algaier1, C. S.
Smith2 and B. Jayaram2. 1Life Sciences Division,
Midwest Research Institute, Kansas City, MO
and 2Environmental Toxicology Program, NIEHS,
#595
TOXICOKINETIC PROFILE OF
BATRACYLIN IN BEAGLE DOGS. L. Jia and
J. E. Tomaszewski. DTP/DCTD, National Cancer
Institute/NIH, Rockville, MD. Sponsor: E. Zahalka.
VALIDATION OF A SELECTIVE METHOD
FOR DETERMINATION OF DOXIFLURIDINE
AND 5-FLUOROURACIL IN DOG PLASMA
BY LC-MS/MS: APPLICATION TO THE
BIOEQUIVALENCE STUDY. E. Jeong1, J.
Kim1, Q. Jin1, W. Kang2, J. Lee1, J. Ha1 and E. Seo1.
1
Pharmacokinetics & Toxicokinetics, Korea Institute
of Toxicology, Daejeon, South Korea and 2College
of Pharmacy, Catholic University of Daegu, Daegu,
South Korea. Sponsor: W. Koh.
ENDOSCOPY FOR INTRADUODENAL
DRUG ADMINISTRATION: COMPARISON
OF THREE ANESTHETIC PROTOCOLS IN
GOTTIGEN MINIPIGS, BEAGLE DOGS AND
RHESUS MONKEYS. S. Authier1, 2, F. Chaurand1,
S. Fournier1 and E. Troncy2. 1Veterinary Services,
LAB. Preclinical Research, Laval, QC, Canada
and 2Biomedicine, Faculty of Veterinary Medicine,
University of Montréal, St-Hyacinthe, QC, Canada.
Sponsor: I. Dean.
THE PHARMACOKINETICS OF 1,
4-DIOXANE AND ITS METABOLITE, βHYDROXYETHOXYACETIC ACID, IN MALE
B6C3F1 MICE. J. J. Soelberg1, A. D. Woodstock1,
R. A. Corley1, B. J. Locey2, R. Clarkson2, S. Sager2
and K. D. Thrall1. 1Battelle, Pacific Northwest
Division, Richland, WA and 2Arcadis G&M of
Michigan, LLC, Southfield, MI.
SATURATION OF RENAL EXCRETION OF A
CHLORINATED BENZOIC ACID HERBICIDE
AS AN EXAMPLE TO DETERMINE A
KINETICALLY BASED MTD. E. Fabian1, E.
Leibold1, C. Hastings2 and B. van Ravenzwaay1.
1
Experimental Toxicology and Ecology, BASF
AG, Ludwigshafen, Germany and 2Toxicology
and Ecotoxicology, BASF Corporation, Research
Triangle Park, NC.
104
45th Annual
Meeting & ToxExpo
#596
EFFECT OF AGE ON TISSUE DISTRIBUTION
OF BDE 47 IN MICE. D. Staskal1, J. J. Diliberto2
and L. S. Birnbaum2. 1Curriculum in Toxicology,
UNC- Chapel Hill, Research Triangle Park, NC and
2
ORD, NHEERL, ETD, U.S. EPA, Research Triangle
Park, NC.
#603
THE PHARMACOKINETICS OF PERFL
UOROOBUTANESULFONATE (PFBS) IN
MONKEYS AND HUMANS. G. Olsen1, P. Lieder1,
P. Noker2, G. Gorman2 and J. Butenhoff1. 13M
Company, St. Paul, MN and 2Southern Research
Institute, Birmingham, AL.
#597
ESTIMATING CONSTANTS FOR
METABOLISM OF ATRAZINE IN PRIMARY
RAT HEPATOCYTES BY KINETIC
MODELING. T. S. McMullin1, 3, W. H. Hanneman1,
B. Cranmer1, J. D. Tessari1 and M. E. Andersen2.
1
Colorado State University, Fort Collins, CO., 2CIIT,
Park, NC and 3Toxicology and Environmental
Research and Consulting, The Dow Chemical
#604
PHARMACOKINETICS OF 3-(4-METHY
LBENZYLIDENE)CAMPHOR IN HUMAN
SUBJECTS. Universtiy of. M. Schauer1, T.
H. Broschard2 and W. Dekant1. 1Department of
Toxicology, University of Wüerzburg, Wüerzburg,
Germany and 2Department of Toxicology, Merck
KGaA, Darmstadt, Germany.
#605
TOXICOKINETICS OF CKD-501 AFTER 13WEEK ORAL ADMINISTRATION IN RATS.
J. Lee1, J. Ha1, J. Hong1, H. Lim1, Q. Jin1, J. Shin2, I.
Hwang2, H. Lee2, S. Ahn2, C. Kim1 and E. Jeong1.
1
Pharmacokinetics and Toxicokinetics, Korea
Institute of Toxicology, Daejeon, South Korea and
2
Chong Kun Dang Pharmacology, Seoul, South
Korea. Sponsor: W. Koh.
#598
#599
#600
#601
#602
METABOLISM AND KINETICS OF 3-(4METHYLBENZYLIDENE)CAMPHOR IN
THE RAT: IMPACT OF THE ROUTE OF
EXPOSURE. T. H. Broschard1, Universtiy of.
Schauer2, A. Heusener1, G. Ziegler1, W. Dekant2,
F. von Landenberg1 and P. Kramer1. 1Institute of
Toxicology, Merck KGaA, Darmstadt, Germany and
2
Institut fuer Toxikologie, Universitaet Wüerzburg,
Wüerzburg, Germany.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
PHARMACOKINETICS AND
BIODISTRIBUTION OF A
PHOSPHORODIAMIDATE MORPHOLINO
OLIGOMER CONJUGATED TO AN
ARGININE-RICH PEPTIDE. A. Amantana, H.
M. Moulton, M. L. Cate, M. T. Reddy, T. Whitehead,
J. N. Hassinger, D. D. Weller and P. L. Iversen.
Toxicology, AVIBioPharma, Inc., Corvallis, OR.
POSTER SESSION: SAFETY EVALUATION—
PHARMACEUTICALS 1 (NEURO, CARDIOVASCULAR,
ENDOCRINE/METABOLIC)
METABOLITE PROFILING OF 14C-RDX IN
MINIATURE PIGS. G. Reddy. Health Effects
Research Program, U.S. Army Center for Health
Promotion and Preventive Medicine, Aberdeen
Proving Ground, MD.
Chairperson(s): Courtney Sulentic, Wright State University, Dayton, OH
and Chudy Nduaka, Pfizer Inc., Groton, CT.
A TWO-PARADIGM STUDY OF
ORAL GAVAGE VS. DIET DOSING
ON PHARMACOKINETICS (PK) AND
PHARMACODYNAMICS (PD) OF A NONSTEROIDAL ANTI-INFLAMMATORY DRUG,
SULINDAC. R. Krishnaraj1, A. Lyubimov1,
T. Martin-Jimenez2 and I. M. Kapetanovic3.
1
Toxicology Research Laboratory, Department of
Pharmacology, University of Illinois at Chicago,
Chicago, IL, 2Toxicology Research Laboratory,
University of Illinois at Chiacgo, Chicago, IL,
3
Department of Veterinary Biosciences, University
of Illinois urbana-Champaign, Urbana, IL and
4
Division of Cancer Prevention, National Cancer
Institute, Bethesda, MD.
IN VIVO PHARMACOKINETIC/
PHARMACODYNAMICS OF BACKBONE
MODIFIED 2’-MOE ANTISENSE
OLIGONUCLEOTIDES (ASO) IN RODENTS.
R. S. Geary, A. Siwkowski, J. Matson, T. Watanabe,
S. P. Henry and A. A. Levin. ISIS Pharmaceuticals,
Inc., Carlsbad, CA.
105
#606
SAFETY OF INTRATHECAL GABAPENTIN
FOR INJECTION IN RATS AND SHEEP.
J. Allen1, L. Page1, G. Stewart1, T. Gradert2, S.
Hassenbusch2, B. Satterfield2, W. Baze2 and K.
Hildebrand1. 1Neurological, Medtronic, Minneapolis,
MN and 2MD Anderson Cancer Center, University
of Texas, Houston, TX.
#607
NEUROTOXICITY OF SOME
ANTICONVULSANT N, N’-SUBSTITUTED
SPIROHYDANTOINS. R. A. Stephani, H. J. Patel
and J. D. Sarra. Pharmaceutical Sciences, St. John’s
University, Jamaica, NY.
#608
A TWO-WEEK REPEAT DOSE TOXICOLOGY
STUDY IN RATS WITH A ONE WEEK
RECOVERY PERIOD WITH RECOMBINANT
RAT NEUBLASTIN. D. R. Demady1, D. Hutto3, A.
Rossomando2, K. Zokowski1, C. Hurst1, J. Clarke1
and K. Rao4. 1Pharmacotoxicology, Biogen Idec Inc.,
Cambridge, MA, 2Protein chemistry, Biogen Idec
Inc., Cambridge, MA, 3Veterinary and Comparative
Pathology, Biogen Idec Inc., Cambridge, MA and
4
Toxicology, Quintiles Inc., Kansas City, MO.
MONDAY
45th Annual
Meeting & ToxExpo
MONDAY
#609
HISTAMINERGIC H1 BLOCKADE AS A
POTENTIAL SOURCE OF THERAPEUTIC
OR ADVERSE EFFECTS OF THE
ANTIPSYCHOTIC DRUG CLOZAPINE:
STUDIES WITH THE H1 ANTAGONIST
PYRILAMINE. C. Roegge, X. Hao, C. Perraut
and E. D. Levin. Department of Psychiatry and
Behavioral Sciences, Duke University Medical
Center, Durham, NC.
#616
STUDY OF POTENTIAL GENOTOXIC AND
EPIGENETIC LIVER CANCER-INDUCING
EFFECTS OF ALAGEBRIUM CHLORIDE
(ALT-711) IN SPRAGUE-DAWLEY (SD) RATS.
A. M. Jeffrey1, M. J. Iatropoulos1, C. E. Perrone2, J.
Duan1, G. M. Williams1 and H. B. Haimes3. 1New
York Medical College, Valhalla, NY, 2Orentreich
Foundation, Cold Spring-on-Hudson, NY and
3
Alteon Inc., Parsippany, NJ.
#610
A 13 WEEK ORAL TOXICITY STUDY OF
NALTREXONE HYDROCHLORIDE IN THE
CYNOMOLGUS MONKEY WITH A 4-WEEK
RECOVERY PERIOD. S. M. McPherson2, J. C.
Tigner1, H. Ibrahim1, J. Jolette2, A. Keyhani2 and
R. Bouchard2. 1Purdue Pharma, Ardsley, NY and
2
Montréal, Senneville, QC, Canada.
#617
#611
FERTILITY AND EARLY EMBRYONIC
DEVELOPMENT STUDY IN SPRAGUEDAWLEY RATS WITH NALTREXONE
HYDROCHLORIDE. K. W. Hew1, J. C. Tigner1, L.
Pouliot2 and K. Robinson2. 1Purdue Pharma, Ardsley,
NY and 2Toxicology, Charles River Laboratories
Preclinical Montréal, Senneville, QC, Canada.
CARDIOPULMONARY SAFETY AND
TOXICOLOGICAL EVALUATION OF
INS50589, A REVERSIBLE P2Y12 RECEPTOR
ANTAGONIST WITH ANTI-PLATELET
AGGREGATION ACTIVITY, ADMINISTERED
BY CONTINUOUS INTRAVENOUS INFUSION
IN BEAGLE DOGS. M. S. Cowlen, C. Crean,
R. Krishnamoorthy, L. Richards, P. Watson and J.
Boyer. Inspire, Durham, NC.
#618
NONCLINICAL EVALUATIONS OF ICA17043: AN INVESTIGATIONAL DRUG FOR
TREATMENT OF SICKLE CELL DISEASE
(SCD). T. B. Grizzle1, G. C. Rigdon1, J. W. Stocker1,
G. A. McNaughton-Smith1 and M. M. Yuschak2.
1
Icagen, Durham, NC and 2McNeil Cons. & Spec.
Pharmaceuticals, Fort Washington, PA.
#619
TOXICOLOGICAL INVESTIGATIONS ON
INHALED INSULIN. W. R. McConnell1, G. Finch1,
M. Elwell1, T. Kawabata1, R. Moutvic2, M. Shaw2
and I. Stammberger3. 1Safety Sciences, Pfizer Global
Research and Development, Groton, CT, 2Battelle,
Columbus, OH and 3the sanofi-aventis Group,
Frankfurt, Germany.
#612
EMBRYO-FETAL DEVELOPMENT STUDY
IN SPRAGUE-DAWLEY RATS WITH
NALTREXONE HYDROCHLORIDE. L.
Pouliot1, K. W. Hew2, J. C. Tigner2, A. Keyhani1, K.
Robinson1, X. P. Fang2 and D. WU2. 1Toxicology,
Senneville, QC, Canada and 2Purdue Pharma,
Ardsley, NY.
#613
THE NONCLINICAL SAFETY PROFILE OF
THE NEURONAL NITRIC OXIDE SYNTHASE
(nNOS) INHIBITOR, CP-695, 516, SUPPORTED
CLINICAL DEVELOPMENT FOR ACUTE
STROKE. B. A. Pettersen, J. M. Marcek, A.
Jacobitz, K. Borg, D. J. Brees, R. B. Nelson, E.
Callegari and C. E. Gavin. Pfizer Global Research &
Development, Groton, CT.
#620
OCULAR EFFECTS OF SORBITOL
DEHYDROGENASE (SDH) INHIBITOR
(SDI), SDI-PFE. J. Singh1, R. Barnes1, M. Aleo1, J.
Lapointe1, C. Somps1, C. Liu1, D. Baltrukonis1, C.
Doshna1, J. Fortner1, J. Render1, B. Ballinger1, C.
Day2, R. Jacob2 and R. Mason2. 1Safety Sciences,
Pfizer, Groton, CT and 2Elucida Research LLC,
Beverly, MA.
#614
ANTIOXIDANT EFFECT OF HMGCOA REDUCTASE DOWN STREAM
METABOLITES ON STATIN-INDUCED
REACTIVE OXYGEN FORMATION IN
HUMAN SKELETAL MUSCLE CELLS.
A. Wolf1, L. Ndountse-Tchapda1, Universtiy of.
Schramm1 and W. E. Trommer2. 1Biomarker
Development, Novartis Pharma AG, Basel,
Switzerland and 2Department of Chemistry,
University of Kaiserslautern, Kaiserslautern,
Germany.
#621
TOXICITY AND KINETICS OF A SELECTIVE
5-HT2C RECEPTOR AGONIST AND
THE RISK ASSOCIATED WITH 5-HT2BMEDIATED VALVULAR HEART DISEASE. T.
Williams, N. Huang, K. Cassidy, R. Moulton and
Y. Hui. Lilly Research Laboratories, Eli Lilly and
Company, Indianapolis, IN.
#622
PHARMACOKINETICS AND METABOLISM
OF A SELECTIVE 5-HT2C RECEPTOR
AGONIST: MODIFICATION OF THE
STRUCTURE TO LIMIT 5-HT2B ACTIVITY. Y.
Hui, N. Huang, K. Cassidy, J. Fayer, M. Reinhard, K.
Briner and T. Williams. Lilly Research Laborotories,
Eli Lilly and Company, Indianapolis, IN.
#623
CERVISTATIN, AN HMG-COA REDUCTASE
INHIBITOR. J. M. DeBoef2, 1, M. P. Smith2, 1, D. F.
Wells1, 2, L. C. Robosky1, M. Reily1, C. V. Okerberg1,
L. Egnash1, D. Gage1 and D. G. Robertson1, 2.
1
Metabonomics Evaluation Group, Pfizer PGRD,
Ann Arbor, MI and 2Safety Sciences, Pfizer PGRD,
Ann Arbor, MI.
#615
SAFETY EVALUATION OF A BAFF DECOY
RECEPTOR (BR3-Fc) IN MONKEYS AND
MICE. T. R. Gelzleichter1, T. M. Nelson1, T.
Kamenosono3, K. R. Moore3, S. Ren1, B. Wu1,
F. Martin1, I. Grewal1, B. N. Thompson2, D. M.
Ehrenfels2, D. M. Danilenko1, K. Howell1 and Y.
Vugmeyster1. 1Genentech, South San Francisco, CA,
2
Biogen Idec, Cambridge, MA and 3SNBL, Seattle,
WA.
106
45th Annual
Meeting & ToxExpo
#624
CJC-1134-PC, A LONG-ACTING EXENDIN-4
ANALOGUE, IS WELL TOLERATED IN RATS
AND MONKEYS FOR UP TO 7 DAYS. S. Wen,
T. Najarian, K. Thibaudeau, J. Woo and J. Castaigne.
ConjuChem, Inc., Montréal, QC, Canada.
#625
RENAL TOLERABILITY OF A
SECOND-GENERATION ANTISENSE
OLIGONUCLEOTIDE (ISIS 113715) IN
MONKEY. T. A. Zanardi1, S. P. Henry1, R. Fey1, M.
Johnson2 and P. B. Lappin3. 1ISIS Pharmaceuticals,
Inc., Carlsbad, CA, 2MPI Research, Mattawan, MI
and 3Charles River Laboratories, Sparks, NV.
#627
#628
#629
#630
#631
#632
A NINE-MONTH CHRONIC TOXICITY
STUDY OF CJC-1131, A LONG-ACTING GLP-1
ANALOGUE. Y. Fukushima1, C. N. Papagiannis2, J.
Castaigne1 and S. Wen1. 1ConjuChem Inc., Montréal,
QC, Canada and 2MPI Research, Inc., Mattawan,
MI.
CHARACTERIZING ANIMAL MODELS OF
PPAR-G AGONIST INDUCED EDEMA. H. S.
Younis1, K. Palacio1, B. Simmons2, K. Ogilvie2, J.
Fraser2 and G. J. Stevens1. 1Safety Sciences, Pfizer
Inc., San Diego, CA and 2Research Pharmacology,
Pfizer Inc., San Diego, CA.
#634
PRE-CLINICAL DEVELOPMENT OF A
MONOCLONAL ANTIBODY TO THE αVβ6
INTEGREN. K. J. Olivier1, M. D. Reed2, A.
Gigliotti2, D. Hutto1 and J. B. Clarke1. 1Biogen Idec
Inc., Cambridge, MA and 2Lovelace Respiratory
Research Institute, Albequerque, NM.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: RESPIRATORY TRACT INJURY: CELLULAR
MECHANISMS
Chairperson(s): Michael Madden, U.S. EPA, Chapel Hill, NC and Adrian
Nicolescu, Queens University, Kingston, ON, Canada.
A TOXICITY STUDY IN RATS TREATED
FOR 1 MONTH WITH LY465608, A PPARα, γ
DUAL AGONIST. V. L. Reynolds1, L. I. Boone1, D.
A. Buenger1, M. A. Carfagna1, K. B. Donnelly1, M.
Fitzsimmons2, J. M. Sullivan1 and G. D. Williams1.
1
Lilly Research Laboratories, Greenfield, IN and
2
Covance Laboratories, Madison, WI.
A TOXICITY STUDY IN BEAGLE DOGS
TREATED FOR 1 MONTH WITH LY465608,
A PPAR ALPHA, GAMMA DUAL AGONIST.
M. A. Carfagna1, L. I. Boone1, D. A. Buenger1, K.
B. Donnelly1, M. Fitzsimmons2, V. L. Reynolds1, J.
M. Sullivan1 and G. D. Williams1. 1Lilly Research
Laboratories, Greenfield, IN and 2Covance Labs,
Madison, WI.
THE PPARα AGONIST FENOFIBRATE
CAUSES INCREASED β-OXIDATION
LEADING TO OXIDATIVE INJURY IN
SKELETAL AND CARDIAC MUSCLE IN THE
RAT. J. C. Pettersen, I. Pruimboom-Brees, D. E.
Amacher, O. L. Francone, S. E. Boldt, R. L. Kerlin
and W. E. Ballinger. Pfizer Global Research &
Development, Groton, CT.
SAFETY ASSESSMENT OF 11BHYDROXYSTEROID DEHYDROGENASE
TYPE 1 KNOCKDOWN USING ANTISENCE
OLIGONUCLEOTIDES IN MICE. K. A. Palacio,
T. McDermott, B. Jessen, G. J. Stevens and H.
Younis. Safety Sciences, Pfizer, San Diego, CA.
LIPOIC ACID INHIBITS SUPEROXIDE
RELEASE IN HUMAN NEUTROPHILS. H.
C. O’Neill1 and C. W. White2, 1. 1Department of
Pharmaceutical Sciences, Program in Toxicology,
UCHSC, Denver, CO and 2Department of Pediatrics,
National Jewish Medical Research Center, Denver,
CO.
ORAL AND ESOPHAGEAL PATHOLOGY IN
MICE FOLLOWING CHRONIC TREATMENT
WITH A TRANSFORMING GROWTH
FACTOR–BETA ANTAGONIST. R. Pawliuk1, E.
Lacasse1, J. Delcarpini1, A. Vitsky1, C. Rogers1, M.
McCourt2, J. Powell2, S. Lonning1 and L. Andrews1.
1
Genzyme Corporation, Framingham, MA and
2
Cambridge Antibody Technology, Cambridge,
United Kingdom.
107
#635
ALDEHYDE DEHYDROGENASES
EXPRESSION DURING POSTNATAL
DEVELOPMENT: LIVER VS. LUNG. M. Yoon1,
M. C. Madden2 and H. A. Barton3. 1NRC Research
Associateship Program, U.S. EPA, Research Triangle
Park, NC, 2NHEERL, U.S. EPA, Research Triangle
Park, NC and 3NCCT, U.S. EPA, Research Triangle
Park, NC.
#636
RECEPTOR-ACTIVATED SMAD AND
CONNECTIVE TISSUE GROWTH FACTOR
LOCALIZATION IN THE PULMONARY
FIBROSIS. S. Asano, H. Higashiyama, D.
Yoshimoto, Y. Okamoto, H. Kikkawa and
M. Kinoshita. Pharmacology Department,
GlaxoSmithKline, Tsukuba Research laboratories,
Ibaraki, Japan.
#637
EFFECT OF PROSTAGLANDINS ON MRP
EXPRESSION IN PRIMARY HUMAN LUNG
CELLS. H. Foth, A. Raemisch, A. W. Torky and E.
Stehfest. Environmental Toxicology, University of
Halle, Halle / Saale, Germany.
#638
ROLE OF CFTR IN THE LUNG’S
GLUTATHIONE ADAPTIVE RESPONSE TO
CIGARETTE SMOKE AND INHIBITION
WITH MYCOPLASMA PNEUMONIAE
INFECTION. C. T. Kariya1, B. J. Day1, 2, R. Martin2
and H. Chu2. 1Toxicology, UCHSC, Denver, CO and
2
Medicine, NJMRC, Denver, CO.
#639
ZINC INDUCES TRANSCRIPTIONAL
ACTIVITY THROUGH A NON-CANONICAL
NF-κB ACTIVATION PATHWAY. D. Cao2, Y.
Kim1, W. Reed1, W. Wu1, I. Jaspers1, R. Silbajoris2
and J. M. Samet2. 1UNC, Chapel Hill, NC and 2HSD,
NHEERL, U.S. EPA, Chapel Hill, NC.
MONDAY
#626
#633
45th Annual
Meeting & ToxExpo
#640
ZN2+ -INDUCED IL-8 EXPRESSION
INVOLVES AP-1, ERK, AND JNK ACTIVITIES
IN HUMAN AIRWAY EPITHELIAL CELLS.
Y. Kim1, W. Reed1, W. Wu1, P. A. Bromberg1, L. M.
Graves1, I. Jaspers1 and J. M. Samet2. 1UNC, Chapel
Hill, NC and 2HSD, NHEERL, U.S. EPA, Chapel
Hill, NC.
#641
REGULATION BY COPPER OF THE
EXPRESSION OF LYSYL OXIDASE AND
COLLAGEN IN CADMIUM-RESISTANT
RAT FETAL LUNG FIBROBLASTS. Y. Zhao1,
S. Gao1, I. Chou2, P. Toselli1, P. Stone1 and W.
Li1. 1Biochemistry, Boston University School of
Medicine, Boston, MA and 2Microbiology, Boston
University School of Medicine, Boston, MA.
#642
MONDAY
#643
POSTER SESSION: CARDIOVASCULAR SYSTEM: ECG AND
HERG
METALLOTHIONEIN DISULFIDES ARE
PRESENT IN METALLOTHIONEINOVEREXPRESSING TRANSGENIC
MOUSE HEART AND INCREASE UNDER
CONDITIONS OF OXIDATIVE STRESS. W.
Feng1, F. W. Benz2, J. Cai2, W. M. Pierce2 and Y.
Kang1, 2. 1Department of Medicine, University
of Louisville, Louisville, KY and 2Department
of Pharmacology and Toxicology, University of
Chairperson(s): Authur Brown, ChanTest, Inc., Cleveland, OH and Ashok
Gupta, Bristol-Myers Squibb Company, Princeton, NJ.
TOXICITY OF AMIODARONE AND
DESETHYLAMIODARONE IN HUMAN
LUNG CELLS IN VITRO; INVESTIGATION
OF CYTOPROTECTION BY NITRONES. J. L.
Comeau, A. C. Nicolescu, J. F. Brien, W. J. Racz and
T. E. Massey. Pharmacology & Toxicology, Queen’s
University, Kingston, ON, Canada.
FREE RADICAL PRODUCTION IN
MITOCHONDRIA EXPOSED TO
AMIODARONE. A. C. Nicolescu, J. F. Brien, W. J.
Racz and T. E. Massey. Pharmacology & Toxicology,
Queen’s University, Kingston, ON, Canada.
#645
MICROARRAY ANALYSIS OF PMINDUCED GENE EXPRESSION IN HUMAN
BRONCHIAL EPITHELIAL CELLS. M. T.
Schmitt, L. A. Dailey, D. W. Graff and R. B. Devlin.
NHEERL/HSD/CRB, U.S. EPA, Research Triangle
Park, NC.
#647
EVALUATION OF TWO MOUSE STRAINS
AS POTENTIAL MODEL SYSTEMS FOR
CHRONIC OBSTRUCTIVE PULMONARY
DISEASE (COPD): UTILIZATION OF
MICROARRAY GENE EXPRESSION
ANALYSIS. R. Rooney1, D. Patel1 and S. Groom2.
1
Genome Explorations, Memphis, TN and
2
Montréal, Senneville, QC, Canada. Sponsor: M.
Vezina.
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
#644
#646
#648
NORMAL GENE EXPRESSION IN MALE
AND FEMALE SPRAGUE-DAWLEY RAT
NASAL RESPIRATORY AND OLFACTORY
EPITHELIA. E. S. Roberts, N. V. Soucy, A. M.
Bonner and D. C. Dorman. CIIT Centers for Health
AIRWAY PROTEOMICS IN THE MOUSE
LUNG: A COMPARISON OF TWO
APPROACHES AND THEIR ABILITY TO
DETECT SEX DIFFERENCES IN AIRWAY
PROTEINS. K. M. Sutherland, M. A. Isbell and
L. S. Van Winkle. VM:APC/CHE, UC Davis, Davis,
CA.
108
#649
CARDIOVASCULAR AND RESPIRATORY
VALIDATION STUDY IN TELEMETERIZED
CYNOMOLGUS MONKEYS AND BEAGLE
DOGS. J. S. Lafferty1, 2, N. Caya1, 2, J. Bultman2,
J. K. Herman1, 2 and R. D. Sarazan1, 2. 1Safety
Pharmacology, Covance Laboratories, Madison, WI
and 2Toxicology, Covance Laboratories, Madison,
WI.
#650
AN INTEGRATED CARDIOVASCULAR
RISK ASSESSMENT FOR SAFETY
PHARMACOLOGY: IN-VIVO AND INVITRO EFFECTS OF DL-SOTATOL AND
HALOPERIDOL. K. Norton1, S. Mason1, C.
Banks1, D. Guergues2 and D. Salvail2. 1Toxicology,
Senneville, QC, Canada and 2IPS Therapeutique
Inc., Sherbrooke, QC, Canada.
#651
A COST- AND TIME-EFFECTIVE QT-SCREEN
COMBINES IN-VIVO MEASUREMENTS
IN GUINEA-PIGS WITH IN-VITRO HERG
CURRENT INHIBITION. N. Hebert1, D. Salvail2,
S. Mason1, C. Banks1 and J. Layer2. 1Toxicology,
Senneville, QC, Canada and 2IPS Therapeutique
Inc., Sherbrooke, QC, Canada.
#652
OPTIMATISON OF A NON-INVASIVE
TELEMETRY SYSTEM FOR
ELECTROCARDIOGRAM ASSESSMENT IN
DOGS: A 3-YEARS REVIEW. N. McMahon,
J. Schofield, H. Prior, D. Hamre, D. Simpson, T.
Hammond and J. Valentin. Safety Pharmacology,
Safety Assessment, AstraZeneca R&D, Macclesfield,
United Kingdom.
45th Annual
Meeting & ToxExpo
#653
CARDIOVASCULAR ASSESSMENT
OF BICIFADINE HCL IN CONSCIOUS,
RADIOTELEMTRY-IMPLANTED
CYNOMOLGUS MONKEYS. M. V. Soloviev1,
J. P. Tizzano4, L. Freshwater2 and J. Buelke-Sam3.
1
WIL Research Laboratories, LLC, Ashland, OH,
2
BioSTAT Consultants, Portage, MI, 3Toxicology
Services, Greenfield, IN and 4DOV Pharmaceutical,
Inc., Hackensack, NJ. Sponsor: C. Chengelis.
#654
RELATIONSHIP AMONG DRUG-INDUCED
PROLONGATION OF CORRECTED QT, OF
CORRECTED JT, AND DURATION FROM
PEAK TO END OF T-WAVE IN A TELEMETRY
GUINEA PIG MODEL. M. Shiotani, T. Harada,
J. Abe, Y. Hamada and I. Horii. Worldwide Safety
Sciences, Pfizer Global Research & Development,
Nagoya Laboratories, Pfizer Inc., Aichi, Japan.
Sponsor: M. Kurata.
#655
TORSADOGENIC DRUGS INCREASE
ELECTRICAL ALTERNANS MEASURED
IN LANGENDORFF PERFUSED RABBIT
HEARTS. J. Kramer1, A. Brown1, 2, G. Kirsch1
and T. Yang1. 1ChanTest Inc., Cleveland, OH and
2
Physiology & Biophysics, Case Western Reserve
University, Cleveland, OH.
#656
COMPARISON OF COMMON METHODS
FOR QT INTERVAL DATA CORRECTION AT
HIGH HEART RATES. J. R. May, M. P. Benson, T.
J. Baird and P. E. Newton. MPI Research, Mattawan,
MI.
#657
EFFECTS OF INHALATION DOSING
PROCEDURES ON BASELINE
CARDIOVASCULAR PARAMETERS
AND RESPONSE TO D, L-SOTALOL IN
CONSCIOUS TELEMETERED DOGS. K. G.
Meecham, D. J. Beard, S. A. Moore, P. H. Davies
and C. J. Hardy. Huntingdon Life Sciences Ltd.,
Huntingdon, United Kingdom.
#658
EFFECTS OF VERAPAMIL AND SOTALOL
ON ECG INTERVALS IN THE CONSCIOUS
TELEMETERED MINIPIG. D. J. Beard, P.
H. Davies, K. G. Meecham and C. J. Hardy.
Huntingdon Life Sciences Ltd., Huntingdon, United
Kingdom.
#659
ALFUZOSIN TESTS POSITIVE IN
NONCLINICAL ASSAYS. A. E. Lacerda1, Y. A.
Kuryshev1, M. Renganathan1, H. Eng1, L. Dewey1, S.
J. Danthi1, J. W. Kramer1, T. Yang1 and A. M. Brown1,
2 1
. ChanTest Inc., Cleveland, OH and 2Physiology
& Biophysics, Case Western Reserve University,
Cleveland, OH.
#660
RESPIRATORY SAFETY PHARMACOLOGY
STUDIES USING SNOUT-ONLY
PLETHYSMOGRAPHS AND TELEMETRY
FOR RECORDING INTRAPLEURAL
PRESSURE DURING IN CONSCIOUS CD
RATS: A VALIDATION STUDY USING AN
AEROSOL OF METHACHOLINE. R. M.
Huckle, G. A. Graham, K. G. Meecham and C. J.
Hardy. Huntingdon Life Sciences Ltd., Huntingdon,
United Kingdom.
109
#661
A COMPARISON OF HEART RATE AND
ECG DATA COLLECTED USING THE
VIVOMETRICS LIFESHIRTâ AND A
STANDARD DSI TELEMETRY DEVICE. H.
Penton1, S. Mason1, K. Norton1, C. Banks1 and
A. Derchak2. 1Toxicology, Charles River Labs,
Senneville, QC, Canada and 2VivoMetrics, Ventura,
CA.
#662
INTEGRATED NONCLINICAL
CARDIOVASCULAR SAFETY EVALUATION
OF A MIXED ION CHANNEL INHIBITOR. R.
Peri, A. K. Gupta, S. R. Arthur, S. V. Mandlekar, G.
Cornelius, J. Zhu, E. Burnett, L. Sun, D. Li, P. C.
Levesque, B. D. Car and B. Gemzik. Bristol-Myers
Squibb, Princeton, NJ.
#663
CARDIAC ION CHANNEL APPLICATIONS
OF PATCHXPRESS® AUTOMATED
ELECTROPHYSIOLOGY. Y. A. Kuryshev1, J.
Brimecombe1, G. E. Kirsch1 and A. M. Brown1,
2 1
. ChanTest Inc., Cleveland, OH and 2Physiology
Cleveland, OH.
#664
SAFETY PHARMACOLOGY: IN VITRO
AND EX VIVO EFFECTS OF URIDINE
TRIPHOSPHATE ON CARDIAC
ELECTROPHYSIOLOGY AND
HEMODYNAMICS. D. Salvail2, M. R. Gralinski1,
E. Tanhehco1 and G. Page2. 1Cordynamics
Inc., Chicago, IL and 2IPS Therapeutique Inc.,
Sherbrooke, QC, Canada.
#665
EFFECTS OF BICIFADINE HCL ON
CLONED HERG CHANNELS EXPRESSED
IN MAMMALIAN CELLS. J. Brimecombe3,
G. E. Kirsch3, H. Erickson3, G. J. Schaefer1 and
J. P. Tizzano2. 1WIL Research Laboratories,
LLC, Ashland, OH, 2DOV Pharmaceutical, Inc.,
Hackensack, NJ and 3ChanTest, Inc., Cleveland, OH.
#666
INHIBITION OF HERG TRAFFICKING
BY CARDIAC GLYCOSIDES. B. Wible1, Y.
Kuryshev1, P. Hawryluk1 and A. M. Brown1, 2.
1
ChanTest Inc., Cleveland, OH and 2Physiology
Cleveland, OH.
#667
INHIBITORY EFFECTS OF PDE INHIBITORS
ON HERG CURRENTS; DOES PKA
REGULATE HERG CHANNEL ACTIVITY? K.
Yunomae, S. Ichisaki, J. Matsuo, M. Haruyama, S.
Nagayama, T. Susumu, K. Fukuzaki, R. Nagata and
G. Kito. SNBL DSR, Kagoshima, Japan.
MONDAY
45th Annual
Meeting & ToxExpo
Monday, March 6
1:30 PM to 4:30 PM
Exhibit Hall
#674
PROLIFERATION OF HUMAN CACO-2
CELLS MEDIATED BY N-ACETYLATION
AND OXIDATION REACTIONS OF 3-AMINO4-HYDROXYBENZENEARSONATE (AHBA).
G. S. Bayse1, K. M. Jackson1, W. G. Kirlin2 and A.
M. Rollins-Hairston2. 1Chemistry, Spelman College,
Atlanta, GA and 2Pharmacology/Toxicology,
Morehouse School of Medicine, Atlanta, GA.
#675
CURCUMIN GLUCURONIDE INHIBITS
CELL-FREE MICROTUBULE ASSEMBLY. E.
Pfeiffer1, S. G. Walch1, A. Riess1, S. I. Hoehle1, A.
M. Solyom2 and M. Metzler1. 1Food Chemistry and
Toxicology, University of Karlsruhe, Karlsruhe,
Germany and 2Pharmacology and Toxicology,
#676
PHASE I ENZYMES EXPRESSED IN NONSMALL CELL LUNG CANCER. T. Oyama1, T.
Kinaga1, M. Ogawa1, T. Murakami1, T. Yamaguchi1,
T. Isse1, N. Kunugita2 and T. Kawamoto1.
1
Department of Environmental Health, School
of Medecine, University of Occupational and
Environmental Health, Kitakyushu, Japan and
2
Department of Health Information Science, School
of Health Science, University of Occupational and
Environmental Health, Kitakyushu, Japan.
#677
COMPETITIVE INHIBITION OF CYP 1A1
ACTIVITY BY 3-O-ACETYLATED CATECHIN
IN HEPATIC MICROSOME. D. Kim1, E. Han1,
2
, K. Oh1, 2, Y. Hwang1, 2, T. Jeong3, E. Lee3 and H.
Jeong1, 2. 1Pharmacy, Chosun University, Kwangju,
South Korea, 2College of Pharmacy, Research Center
for Proteineous Materials, Chosun University,
Kwangju, South Korea and 3College of Pharmacy,
Yeungnam University, Kyungsan, South Korea.
#678
ROLE OF PULMONARY CYP3A1 IN 1NITRONAPHTHALENE INDUCED ACUTE
LUNG INJURY IN POSTNATAL AND ADULT
RATS. K. C. Day, L. M. Davison, B. N. DeLong,
C. G. Plopper and M. V. Fanucchi. Vet. Med.:
Anatomy, Physiology and Cell Biology, University
of California, Davis, Davis, CA.
#679
THE RELATIONSHIP AMONG
MICROSOMAL ENZYME INDUCTION,
LIVER WEIGHT, AND HISTOLOGICAL
CHANGE IN CYNOMOLGUS MONKEY
TOXICOLOGY STUDIES. S. J. Schomaker, S.
E. Boldt, M. Mirsky and D. E. Amacher. Safety
Sciences Groton, Pfizer Inc., Groton, CT.
#680
ONTOGENY OF TRICHLOROETHYLENE
(TCE) METABOLISM IN IMMATURE
SPRAGUE-DAWLEY (S-D) RATS. B. McPhail,
S. Muralidhara, S. S. Anand and J. V. Bruckner.
Toxicology, University of Georgia, Athens, GA.
#681
ROLE OF CYP3A METABOLISM OF
CHLOROACETANILIDE HERBICIDES
IN CYTOTOXICITY OF ISOLATED RAT
HEPATOCYTES. V. M. Kale and S. A. Meyer.
Toxicology, University of Louisiana-Monroe,
Monroe, LA.
POSTER SESSION: METABOLISM TOXICITY AND
POLYMORPHISMS
Chairperson(s): Sharon Meyer, University of Louisiana, Monroe, LA.
#668
#669
A COMBINED QUANTITATIVE
STRUCTURE ACTIVITY RELATIONSHIP
AND SYSTEMS BIOLOGY APPROACH
TO DRUG METABOLISM AND TOXICITY
ASSESSMENT. S. Ekins1, 2, S. Andreyev1, A.
Ryabov1, E. Kirillov1, E. Rakhmatulin1, S. Sorokina1,
A. Bugrim1 and T. Nikolskaya1. 1GeneGo Inc., St
Joseph, MI and 2School of Pharmacy, Department of
Pharmaceutical Sciences, University of Maryland,
Baltimore, MD. Sponsor: C. Giroux.
MONDAY
COULD EMERGING GENOMIC
TOOLS ASSIST IN UNDERSTANDING
THE MECHANISMS OF ACTION OF
INSECTICIDE SYNERGISTS? S. Ramasamy and
J. Doherty. OPPTS, U.S. EPA, Arlington, VA.
#670
ONCOGENIC SIGNALING PATHWAYS
ACTIVATED IN DMBA-INDUCED MAMMARY
TUMORS IN MICE. S. E. Solomon1, N. Currier3,
D. Seldin3, 1 and D. Sherr2, 1. 1Pathology, Boston
University School of Medicine, Boston, MA,
2
Environmental Health, Boston University School of
Public Health, Boston, MA and 3Medicine, Boston
#671
INSULIN SIGNALING IN REGULATION
OF ALPHA-CLASS GLUTATHIONE STRANSFERASE EXPRESSION IN PRIMARY
CULTURED RAT HEPATOCYTES. S. K.
Kim1, M. A. Abdelmegeed2, S. Oh1 and R. F.
Novak2. 1College of Pharmacy, Chungnam National
University, Deajeon, South Korea and 2Institute
of Environmental Health Sciences, Wayne State
University, Detroit, MI.
#672
#673
ROLE OF GLUTATHIONE CONJUGATION
IN THE HEPATOTOXICITY AND
IMMUNOTOXICITY INDUCED BY 1BROMOPROPANE IN FEMALE BALB/C
MICE. S. Lee1, T. Jeon1, Y. Kim2, E. Lee1 and T.
Jeong1. 1College of Pharmacy, Yeungnam University,
Gyeongsan, South Korea and 2Korea Institute of
Toxicology, Daejon, South Korea.
CHARACTERIZATION OF HEPATIC
AND OLFACTORY GLUTATHIONE STRANSFERASES OF COHO SALMON
(ONCORHYNCHUS KISUTCH). M. Trute, H.
LaVire, P. Janssen and E. Gallagher. Department of
110
45th Annual
Meeting & ToxExpo
#682
METABOLITES OF TRYPTANTHRIN BY RAT
LIVER MICROSOMES. G. Kim, S. Lee, T. Jeon,
C. Jin, I. Jun, D. Lee, Y. Jahng and T. Jeong. College
of Pharmacy, Yeungnam University, Gyeongsan,
South Korea.
#683
CHARACTERIZATION OF HUMAN LIVER
CYTOCHROME P450 ENZYMES INVOLVED
IN THE METABOLISM OF RUTAECARPINE.
T. Jeong1, D. Lee1, S. Lee1, D. Kim2, E. Lee1 and Y.
Jahng1. 1College of Pharmacy, Yeungnam University,
Gyeongsan, South Korea and 2Bioanalysis and
Biotransformation Research Center, KIST, Seoul,
South Korea.
#684
DETERMINATION OF ANTHRICIN AND
ITS METABOLITES IN VITRO BY LIQUID
CHROMATOGRAPHY/ELECTROSPRAY
IONIZATION-TANDEM MASS
SPECTROMETRY. I. Jun, S. Lee, T. Jeon, G.
Kim, D. Lee, C. Jin, S. Lee and T. Jeong. College of
Pharmacy, Yeungnam University, Gyeongsan, South
Korea.
#685
IN VITRO METABOLISM OF
ETHYLBENZENE BY RAT, MOUSE AND
HUMAN LIVER AND LUNG MICROSOMES.
S. A. Saghir, D. L. Rick, M. J. Bartels and J. S. Bus.
The Dow Chemical Company, Midland, MI.
#686
HUMAN CYP 450 ISOFORM SPECIFIC
METABOLISM OF POLYCHLORINATED
BIPHENYL IUPAC #101. J. E. McGraw and D. P.
Waller. Biopharmaceutical Sciences, University of
IL at Chicago College of Pharmacy, Chicago, IL.
#687
HEPATIC P450 ENZYMES PLAY A
DOMINANT ROLE IN THE DISPOSITION OF
7, 12-DIMETHYLBENZ[A]ANTHRACENETRANS-3, 4-DIHYDRODIOL IN MICE. J. Gu,
H. Cui, W. Yang and X. Ding. Wadsworth Center,
Albany, NY.
#688
ROLE OF THIOACETAMIDE-SULFOXIDE
METABOLISM IN SATURATION KINETICS
OF THIOACETAMIDE. J. Chilakapati1, M. C.
Korrapati1, R. A. Hill2 and H. M. Mehendale1.
1
Toxicology, ULM, Monroe, LA and 2Basic
Pharmaceutical Sciences, ULM, Monroe, LA.
#689
COMPARISON OF HALO- AND
NITROBENZENE TOXICITY IN RAT AND
HUMAN HEPATOCYTES. N. Jensen2, K. Chan1,
P. Silber2 and P. O’Brien1. 1Pharmaceutical Sciences,
University of Toronto, Toronto, ON, Canada and 2In
Vitro Technologies Inc., Baltimore, MD.
#690
TRANSESTERIFICATION OF
METHYLPARABEN BY RAT
GASTROINTESTINAL SEGMENTS. M.
Lakeram1, D. J. Lockley2, R. Pendlington2 and B.
Forbes1. 1King’s College London, Pharmaceutical
Science Research Division, London, United
Kingdom and 2Safety and Environmental Assurance
Centre, Unilever Colworth, Bedfordshire, United
Kingdom. Sponsor: D. Basketter.
111
#691
METABOLISM OF ETHNAOL IN
ADH-DEFICENT HEPG2 CELLS AND
ADH-OVEREXPRESSED VA-13 CELLS:
SINGIFICANCE OF NONOXIDAITVE
METABOLISM IN ETHANOL-INDUCED
TOXICITY. B. S. Kaphalia. Pathology, University
of Texas Medical Branch, Galveston, TX.
#692
NONOXIDATIVE METABOLISM OF
ETHANOL TO FATTY ACID ETHYL ESTERS
AND THEIR CYTOTOXICITY IN AR42J
CELLS. H. Wu1, G. A. Ansari1 and B. S. Kaphalia1.
1
Pathology, University of Texas Medical Branch,
Galveston, TX, 2Pathology, University of Texas
Medical Branch, Galveston, TX and 3Pathology,
University of Texas Medical Branch, Galveston, TX.
#693
ALDEHYDE DEHYDOROGENASE 2
METABOLIZES PROPIONALDEHYDE.
- IN VITRO ANALYSIS WITH LIVER
SUBCELLULAR FRACTION DERIVED FROM
ALDH2 KNOCKOUT MOUSE. -. T. Yamaguchi1,
T. Oyama1, T. Isse1, M. Ogawa1, T. Murakami1,
T. Kinaga1, K. Kitagawa2, I. Uchiyama3 and T.
Kawamoto1. 1Environmental Health, University
of Occupational and Environmental Health,
Kitakyushu, Fukuoka, Japan, 2First Department
of Biochemistry, Hamamatsu Medical University,
Hamamatsu, Shizuoka, Japan and 3Environmental
hygiene, Kyoto University, Kyoto, Japan.
#694
CHARACTERIZATION OF TWO RAT
CARBOXYLESTERASES INVOLVED IN
PYRETHROID METABOLISM. M. K. Ross, S.
E. Lentz and A. Borazjani. Center for Environmental
Health Sciences, Mississippi State University,
Mississippi State, MS.
#695
THE EFFECT OF DIELDRIN EXPOSURE
ON SEVERAL ENZYMES RESPONSIBLE
FOR THE METABOLISM OF
ORGANOPHOSPHORUS INSECTICIDES.
J. A. Crow1, H. W. Chambers2, E. C. Meek1 and J.
E. Chambers1. 1Center for Environmental Health
Sciences, Mississippi State University, Mississippi
State, MS and 2Department of Entomology,
Mississippi State University, Mississippi State, MS.
#696
A SPECTROSCOPIC STUDY OF THE
INTERACTION OF 1, 3-DINITROBENZENE
WITH NEURONAL NITRIC OXIDE
SYNTHASE AND ITS ISOLATED HEME
DOMAIN. J. Tobias1 and R. T. Miller2. 1Toxicology,
University of Kentucky, Lexington, KY and
2
Biological Sciences, University of Texas at El Paso,
El Paso, TX.
MONDAY
45th Annual
Meeting & ToxExpo
#697
EFFECTS OF CYP AND GST GENETIC
POLYMORPHISMS ON THE URINARY
LEVELS OF 1-HYDROXYPYRENE IN
TURKISH COKE OVEN WORKERS. M.
Iscan1, M. Yilmazer2, A. O. Ada1, S. Suzen1, A. E.
Demirbag3, S. Efe4, Y. Alemdar4 and S. Burgaz2.
1
Department of Toxicology, Ankara University,
Faculty of Pharmacy, Ankara, Turkey, 2Department
of Toxicology, Gazi University, Faculty of Pharmacy,
Ankara, Turkey, 3Department of Gastrointestinal
Department, Yuksek Ihtisas Hospital, Ankara, Turkey
and 4Eregli Iron and Steel Works Co., Karadeniz
Eregli, Turkey.
#703
A SINGLE NUCLEOTIDE PROMOTER
POLYMORPHISM (SNP) PLACES THE
HUMAN VEGF-RECEPTOR FLT-1 IN THE P53
STRESS-RESPONSE TRANSCRIPTIONAL
NETWORK. G. Schoenfelder1, D. Menendez2, O.
Krysiak1, A. Inga1, 3, B. Krysiak1 and M. Resnick2.
1
Institute of Clinical Pharmacology and Toxicology,
Charite, Berlin, Germany, 2Chromosome Stability
Section, Laboratory of Molecular Genetics, Institute
of Environmental Health Sciences, NIH, Research
Triangle Park, NC and 3Laboratory of Experimental
Oncology B, National Cancer Research Institute,
IST, Genoa, Italy. Sponsor: R. Stahlmann.
#698
N-ACETYLTRANSFERASE 2 GENOTYPE
IN BLADDER CANCER PATIENTS. M. A.
Greaves1, 2, G. Banfi3, K. Golka2, D. Dannappel2 and
I. Romics3. 1Pharmacology, Luis Razetti Medical
School, Universidad Central de Venezuela, Caracas,
Venezuela, 2Clinical Occupational Medicine, Institut
fuer Arbeitsphysiologie, Dortmund University,
Dortmund, Nord Rhein Westfalia, Germany and
3
Department of Urology, Semmelweiss University,
Budapest, Hungary.
#704
METABOLISM AND TOXICITY OF
STYRENE AND HALOGENATED STYRENE
DERIVATIVES IN CYP2E1 TRANSGENIC
CELLS. J. Chung, W. Yuan and J. Zheng.
Pharmaceutical Sciences, Northeastern University,
Boston, MA.
MONDAY
#699
LEAD AND ALAD POLYMORPHISM: WHERE
DOES IT LEAD? A META-ANALYSIS. F.
Scinicariello1, E. Murray1, D. Moffett1, H. Abadin1,
M. Sexton2 and B. Fowler1. 1CDC/ATSDR, Atlanta,
GA and 2Epidemiology Consultant, Atlanta, GA.
#700
RELATIONSHIP OF ALCOHOL
DEHYDROGENASE 2 GENOTYPE IN FETAL
ALCOHOL SPECTRUM DISORDERS. N. M.
Spiegl1, J. L. Powell1, K. S. Squibb1, J. O’Kane2 and
J. D. Cook2. 1Toxicology, University of Maryland
School of Medicine, Baltimore, MD and 2Medical
and Research Technology, University of Maryland
School of Medicine, Baltimore, MD.
Monday, March 6
4:30 PM to 6:00 PM
Room 7A
ROUNDTABLE SESSION: THE COMPLEXITIES OF AIR
POLLUTION REGULATION: THE NEED FOR AN INTEGRATED
RESEARCH AND REGULATORY PERSPECTIVE
Chairperson(s): Srikanth S. Nadadur, U.S. EPA, Research Triangle Park,
NC and Daniel Costa, U.S. EPA, Research Triangle Park, NC.
Endorsed by:
Inhalation SS*
Risk Assessment SS
#701
EFFECT OF POLYMORPHISMS IN THE
MGMT GENE ON HPRT GENE MUTATION
FREQUENCY AND ON MGMT PROTEIN
ACTIVITY AS MEASURED BY A NOVEL
FLUORESCENCE-BASED ASSAY. C. E. Hill, J.
K. Wickliffe, C. J. Kinslow, K. J. Wolfe, C. S. Hallberg
and S. Z. Abdel-Rahman. Preventive Medicine and
Community Health, University of Texas Medical
Branch, Galveston, TX.
#702
POLYMORPHISM AND GENE EXPRESSION
OF THYMIDYLATE SYNTHASE AND
DIHYDROPYRIMIDINE DEHYDROGENASE
IN THE PREDICTION OF SENSITIVITY TO
FLUOROPYRIMIDINE DRUGS. A. MiyajimaTabata1, S. Ozawa1, A. Yawata2, S. Kim3, S. Ishida1,
M. Sunouchi1, J. Sawada4 and Y. Ohno1. 1Division of
Pharmacology, National Institute of Health Sciences,
Tokyo, Japan, 2Department of Hygienic Chemistry,
Showa Pharmaceutical University, Machida, Japan,
3
Project Team for Pharmacogenetics, National
Institute of Health Sciences, Tokyo, Japan and
4
Division of Biochemistry and Immunochemistry,
National Institute of Health Sciences, Tokyo, Japan.
Sponsor: M. Ema.
The U.S. Environmental Protection Agency is currently reassessing existing
and new science that underlies current PM and ozone regulation. The
scientific literature from air quality to epidemiological studies suggest
the existence of toxic entities in the ambient and potential adverse health
effects associated with their exposure. Animal toxicology studies have yet
to provide convincing dose-appropriate evidence to support the adverse
human health effects reported in epidemiological studies. The lack of
molecular mechanisms indicating the biological plausibility for health
effects and uncertainties associated with epidemiological investigations
necessitate the need for developing an integrated research strategy by
scientists from various disciplines in a larger more comprehensive forum
to define health outcomes and risks. The present symposium is a ‘think
outside the box’ forum to facilitate innovative global perspectives on air
pollution from bench to public health outcomes inclusive of risk assessment and regulation. The panel will discuss current research efforts in
understanding the complexities of ‘One atmosphere’ approaches to air
pollution and the impacts on public health and the scientific basis of
regulation. The issues discussed will include (1) the state of the art efforts
for a comprehensive qualitative and quantitative analysis of the air sheds
across U.S.; (2) determination of air quality based on sources of emission
characteristics and reduction in source; (3) air quality and health effects
assessments; (4) potential toxic constituents in the ambient as determined
by animal toxicology studies and; (5) integrative analyses utilized in developing criteria for regulation of PM from the ‘one atmosphere’ approach.
The objective is open and free discussion of current and alternative
approaches to address public health concerns regarding air quality regulation effectively and efficiently.
112
45th Annual
Meeting & ToxExpo
#705
4:30
THE COMPLEXITIES OF AIR POLLUTION
REGULATION: THE NEED FOR
AN INTEGRATED RESEARCH AND
REGULATORY PERSPECTIVE. S. S. Nadadur1
and D. L. Costa2. 1Environmental Media Assessment,
U.S. EPA, Research Triangle Park, NC and 2ORD,
#706
4:36
PM COMPOSITION, SOURCES, AND THEIR
HEALTH EFFECTS. P. K. Hopke. Center for
Air Resources Engineering and Science, Clarkson
University, Potsdam, NY. Sponsor: S. Nadadur.
#707
4:46
LINKING HEALTH EFFECTS TO SOURCES
OF PARTICULATE MATTER: IMPACTS OF
SOURCE OPERATION AND DESIGN ON
PARTICLE ATTRIBUTES. A. Miller and W. P.
Linak. Office of Research and Development, U.S.
EPA, Research Triangle Park, NC. Sponsor: S.
Nadadur.
#711
4:30
DISTANCE LEARNING IN TOXICOLOGY:
EFFECTIVE TEACHING THROUGH
TECHNOLOGY. J. Huggins1, J. Duffus3, J. Morris2
and K. Willett4. 1Bioscience and Biotechnology,
Drexel University, Philadelphia, PA, 2Information
Resources and Technology, Drexel University,
Philadelphia, PA, 3The Edinburgh Centre for
Toxicology, Edinburgh, Scotland, United Kingdom
and 4School of Pharmacy, The University of
Mississipppi, University, MS.
#712
4:40
ASYNCHRONOUS TEACHING AND
LEARNING. J. Morris. Information Resources and
Technology, Drexel University, Philadelphia, PA.
Sponsor: J. Huggins.
#713
4:56
RISK AND BENEFIT ANALYSIS OF AN
ONLINE UNDERGRADUATE TOXICOLOGY
COURSE. K. Willett. School of Pharmacy,
University of Mississippi, University, MS.
#708
4:56
AIR POLLUTION HEALTH EFFECTS: INPUT
TO REGULATIONS. S. Vedal. Environmental
Washington, Seattle, WA. Sponsor: S. Nadadur.
#714
5:12
LEANING WITH THE LEARNING CURVE:
TEACHING TOXICOLOGY ONLINE. J.
Huggins. Bioscience and Biotechnology, Drexel
University, Philadelphia, PA.
#709
5:06
TOXICOLOGICAL PROFILES OF AMBIENT
PM AND GASES. T. Gordon. NYU School of
Medicine, Tuxedo, NY.
#715
5:28
IUPAC’S CONTRIBUTION TO DISTANCE
LEARNING. J. Duffus. The Edinburgh Centre for
Toxicology, Edinburgh, Scotland, United Kingdom.
#710
5:16
MIXTURES WE BREATHE: IMPLICATIONS
FOR AIR QUALITY ASSESSMENT AND
MANAGEMENT. J. Vandenberg. NCEA, U.S. EPA,
Research Triangle Park, NC. Sponsor: S. Nadadur.
#716
5:44
POSTGRADUATE TOXICOLOGY
EDUCATION VIA THE INTERNET. P. Wright2
and D. J. Huggins1. 1Bioscience and Biotechnology,
Drexel University, Philadelphia, PA and 2Key Centre
for Toxicology, RMIT University, Melbourne, VIC,
Australia.
Monday, March 6
4:30 PM to 6:00 PM
Room 6C
Monday, March 6
4:30 PM to 6:00 PM
Room 6F
SUNSET SESSION: DISTANCE LEARNING IN TOXICOLOGY:
EFFECTIVE TEACHING THROUGH TECHNOLOGY
SUNSET SESSION: TOXICOLOGY IN THE COURTROOM:
ESTABLISHING CAUSATION, A ROUNDTABLE DISCUSSION
Chairperson(s): Donna Jane Huggins, Drexel University, Philadelphia,
PA and John Duffus, The Edinburgh Centre for Toxicology, Edinburgh,
Scotland, United Kingdom.
Chairperson(s): Richard Parent, Consultox Ltd., Damariscotta, ME, David
Eaton, University of Washington, Seattle, WA and Bernard Goldstein,
University of Pittsburgh, Pittsburgh, PA.
Endorsed by:
Education Committee*
Distance learning has definitely come of age. On-line courses represent
an impressive knowledge base which is now relatively easy to access by
college students as well as individuals seeking mid-life career changes
and/or advancement. Coupling electronic tools with teaching, asynchrony
with synchrony, distance learning (asynchronous) courses can no longer
be ignored as registration for them expands and types of offerings proliferate. This rapid rate of development has, in many respects, resulted from
an increased awareness and appreciation of these techniques by many
teachers and students. The common-sense practicality associated with these
endeavors has dispelled much of the mysticism surrounding this area of
education. Moreover, distance learning has come down-to-earth for many
people around the globe offering them opportunities for higher education
that, heretofore, would never have been obtainable. Both the thinking and
the technological tools behind development of distance learning courses
in toxicology will be presented. The speakers will be addressing on-line
course content and delivery, nationally and internationally. Current on-line
courses/programs will be discussed with respect to development, efficacy
and quality. Asynchrony will be defined.
Endorsed by:
Ethical, Legal, and Social Issues SS
Risk Assessment SS
Currently both Federal and State courts are attempting to adequately
define criteria for establishing or dismissing causal relationships between
toxicological effects and exposures to various agents such as drugs and
chemicals. Although Federal and State courts in the Frye, Daubert and
Havner rulings have stiffened the requirements for causation, it is the Bradford Hill Criteria (established primarily for assessment of causation using
epidemiological data) that have been the backbone for these efforts. Not
surprisingly, application and interpretation of the Hill Criteria in the courtroom has been variable, often resulting in over reliance on epidemiological
evidence with a lesser role for the more controlled toxicological studies.
From the court’s perspective, there are two types of “causation”: general
causation and specific causation. In the former, the court generally need
only ascertain that there is a reasonable scientific and/or medical basis to
assume that the substance in question is capable causing the alleged injury,
illness or disease in order for the case to move forward. Specific causation
addresses the issue of a personal injury caused or not caused by a particular
drug or chemical within a reasonable degree of scientific or medical prob-
113
MONDAY
45th Annual
Meeting & ToxExpo
ability. Toxicological evidence can play a critical role in establishing both
general and specific causation. The panelists will address the strengths
and limitations of various types of toxicological and epidemiological data
in the context of the causation issue. Issues relating to causation will be
discussed from various viewpoints in hopes of providing some insights and
clarifications for the bench and for litigants. The three participants in this
roundtable are experienced in dealing with these issue both in the courtroom and elsewhere.
#717
4:30
TOXICOLOGY IN THE COURTROOM:
ESTABLISHING CAUSATION, A
ROUNDTABLE DISCUSSION. R. Parent1, D.
L. Eaton2 and B. D. Goldstein3. 1Consultox Ltd.,
Damariscotta, ME, 2Department Env Occup Health
Science, University of Washington, Seattle, WA and
3
Graduate School of Public Health, University of
Monday, March 6
4:30 PM to 6:00 PM
Room 1A
SPECIAL SESSION: USING ANIMALS FOR TOXICOLOGICAL
RESEARCH AND TESTING: BEST PRACTICES FOR ASSURING
COMPLIANCE WITH ANIMAL WELFARE REGULATIONS,
POLICIES, AND GUIDELINES
•
U.S. DA Perspective—Regulatory Compliance Issues for Animals
Used in Toxicological Research and Testing, Jodie Kulpa-Eddy,
U.S. DA Animal and Plant Health Inspection Service, U.S. DA,
Riverdale, MD.
•
Using Animals for Toxicological Research and Testing: Best
Practices for Assuring Compliance with Animal Welfare
Regulations, Policies, and Guidelines, Axel Wolff, NIH, Bethesda,
MD.
•
AAALAC Perspective: Common Animal Care and Use Program
and Facility Recommendations for Improvement for Toxicological
Research and Testing Facilities, John Miller, AAALAC, Rockville,
MD.
•
Canadian Council on Animal Care Perspective: Compliance
Issues and Best Practices for Animals Used for Toxicological
Research and Testing, Clement Gauthier, Canadian Council on
Animal Care, Ottawa, ON, Canada.
•
The UK Home Office Perspective: Regulatory Compliance Issues
and Best Practices for Animals Used for Toxicological Research
and Testing, Jon Richmond, UK Home Office Animals Scientific
Procedures Division, UK Home Office, London, United Kingdom.
MONDAY
Monday, March 6
4:30 PM to 6:00 PM
Room 2
Chairperson(s): Jan Oberdoerster, Bristol-Myers Squibb, East Syracuse,
NY and William Stokes, NIEHS, NIH, DHHS, Research Triangle Park, NC.
CAREER RESOURCE AND DEVELOPMENT SEMINAR: LIFE
AFTER YOUR POST-DOC: ADVICE ON FINDING AND LANDING
A JOB
Sponsored by:
Animals in Research Committee*
Toxicological research and testing often require the use of animals to
investigate mechanisms of toxic action and to accomplish regulatory
safety assessments. This animal use must be conducted in accordance with
applicable animal welfare laws, policies, and regulations. Additionally,
many organizations participate in voluntary accreditation programs, which
also necessitates adherence to best practice standards based on guidelines
published in the NRC/ILAR Guide for the Care and Use of Laboratory
Animals. These requirements and guidelines seek to ensure that investigators use animals in the most humane and judicious manner consistent with
successful attainment of the research or testing objectives, and consistent
with current best practices for animal care and use.
However, institutions face challenges in assuring adherence to best practices in the face of changing research and testing objectives, priorities,
techniques, and animal species, such as in response to recent major
bioterrorism research initiatives. They are also faced with adhering to
evolving changes in best practices for animal care and use in areas such as
environmental enrichment, consideration and use of alternatives, humane
endpoints, management of pain and distress, and animal caging and environment. This workshop will review the most common animal care and
use deficiencies and suggestions for improvement cited by regulatory and
accreditation authorities, and the current best practices used as benchmarks
by these organizations for inspections and site visits of animal care and
use programs and facilities. Perspectives on compliance issues and current
best practices will be provided by U.S. DA APHIS/Animal Care (Animal
Welfare Act regulations), NIH Office of Laboratory Animal Welfare (PHS
Policy on the Humane Care and Use of Laboratory Animals), and the Association for the Assessment and Accreditation of Laboratory Animal Care
International. The Canadian Council on Animal Care and the UK Home
Office will provide international perspectives. Increased understanding of
current animal care and use compliance issues and expected best practices
will facilitate optimization of humane animal care and use by investigators
and laboratory animal veterinarians, and minimize the likelihood of disruptive mandatory corrective actions.
Chairperson(s): Thomas Kawabata, Pfizer, Groton, CT; Julia Kimbell,
CIIT, Research Triangle Park, NC; James Luyendyk, PDA, Scripps
Research Institute, La Jolla, CA; and Janelle Crossgrove, PDA, Purdue
University, West Lafayette, IN.
Endorsed by:
Post-Doctoral Assembly
Your post-doctoral training has been a blast, but now you are thinking
ahead to the next stage of your career. This roundtable discussion will
prepare you for the maze of decisions ahead, providing tips to help you find
and land the job you want. The format of this session will involve a discussion of key questions by a diverse panel of experts from industry, academia
and government. After the responses from the panel, the discussion will be
opened up to the audience. This is intended to be a very interactive session.
•
Scott Loveless, DuPont Haskell Laboratories, Newark, DE.
•
William Greenlee, CIIT, Research Triangle Park, NC.
•
Gregory Cosma, Bristol Myers Squibb, New Brunswick,
NJ.
•
Mark Zorbas, Pfizer Global Research and Development,
San Diego, CA.
•
Linda Birnbaum, U.S. EPA, Research Triangle Park, NC.
•
Bryan Copple, University of Kansas Medical Center,
Kansas City, KS.
114
45th Annual
Meeting & ToxExpo
Monday, March 6
4:30 PM to 6:00 PM
Room 14B
Monday, March 6
7:15 PM to 8:30 PM
Room 11A
SPECIALTY SECTION PRESIDENTS MEETING
REGULATORY AND SAFETY EVALUATION SPECIALTY
SECTION: GREAT DEBATE: HUMAN AND ANIMAL TESTING:
WHAT’S APPROPRIATE?
If you will be a President or a Vice President of a Specialty Section in
2006–2007, please make plans to attend the Specialty Section President
meeting scheduled for 4:30 PM–6:00 PM on Monday, March 6. The
agenda for the meeting will include an overview of the SOT Long-Range
Plan. If you have long-range planning ideas that you would like added to
the agenda, please send a message to Rita Rose at SOT Headquarters. The
agenda will include information on the scientific session selection process,
budgetary guides, a review of 2005–2006 activities, and plans for the
future.
Monday, March 6
5:00 PM to 8:00 PM
Speakers: Joe Rodricks, ENVIRON Health Sciences, Arlington, VA; John
Doull, University of Kansas Medical Center, Kansas City, KS; and Chad
Sandusky, Physicians Committee for Responsible Medicine,Washington,
DC.
The Regulatory and Safety Evaluation Specialty Section (RSESS) is planning to have another “Great Debate.” The debate will be conducted after
the business meeting at our Regulatory and Safety Evaluation Specialty
Section reception.
Tuesday Morning
SPECIAL INTEREST GROUP MEETING/RECEPTION:
AMERICAN ASSOCIATION OF CHINESE IN TOXICOLOGY:
DISTINGUISHED CHINESE TOXICOLOGIST LECTURE
Monday, March 6
5:30 PM to 8:00 PM
Columbia Rooms 1 & 2
REGIONAL CHAPTER PRESIDENTS MEETING
If you will be a President or a Vice President of a Regional Chapter in
2006–2007, please make plans to attend the Regional Chapters Presidents
meeting scheduled for 7:00 AM–8:30 AM Tuesday, March 7. The agenda
for the meeting will include an overview of the SOT Long-Range Plan.
If you have long-range planning ideas that you would like added to the
agenda, please send a message to Rita Rose at SOT Headquarters. The
agenda will include Headquarters administrative support information,
budgetary guides, a review of 2005–2006 activities, and plans for the
future.
KOREAN TOXICOLOGISTS ASSOCIATION IN AMERICA
Monday Evening
Monday, March 6
6:00 PM to 7:30 PM
See Events Calendar on page 2-6 for Room Listings
Tuesday, March 7
7:30 AM to 8:50 AM
Room 2
SPECIALTY SECTION MEETINGS/RECEPTIONS:
CARCINOGENESIS, DRUG DISCOVERY,
IMMUNOTOXICOLOGY, MECHANISMS, MIXTURES
REGULATORY AND SAFETY EVALUATION
ROUNDTABLE SESSION: THE PRECAUTIONARY PRINCIPLE
—IMPLICATIONS AND APPLICATIONS
Chairperson(s): Steven Gilbert, Institute of Neurotox & Neurological
Disorders, Seattle, WA.
Monday, March 6
6:00 PM to 8:00 PM
Marina Ballroom E
Endorsed by:
SPECIAL INTEREST GROUP MEETINGS/RECEPTION:
THE ASSOCIATION OF SCIENTISTS OF INDIAN ORIGIN IN
AMERICA
Monday, March 6
6:00 PM to 8:00 PM
See Events Calendar on page 2-6 for Room Listings
REGIONAL CHAPTER MEETINGS/RECEPTIONS
Many of the Regional Chapters meet during the SOT Annual Meeting.
Details for these Regional Chapter receptions and meetings are listed in the
Events Calendar.
The precautionary principle (PP) as an approach to decision making
on issues related to environmental and human health is controversial.
However, the precautionary principle is receiving increased attention
in North America and Europe as a supplement to risk assessment. The
foundation of the precautionary principle can be expressed as the commonsense advice to “err on the side of caution.” It is intended to apply to a
range of situations that involve both a threat of harm as well as scientific
uncertainty. While the PP may seems like common-sense to some to some
people, others are concerned the application of the PP will needlessly
increase costs and stifle technological advancements. This workshop
will start by providing an overview of the PP with historical examples of
lessens learned. Next, is an examination of decisions making in the face of
the uncertainty that often confronts issues of cause and effect. Alternatives
approaches such as green chemistry will be considered. Finally, there will
be a more critical examination of the PP with an opportunity for discus-
115
MONDAY
Tuesday, March 7
7:00 AM to 8:30 AM
Room 14B
45th Annual
Meeting & ToxExpo
sion of the applications and implications of widespread use of the PP as an
approach to decision making.
#725
7:45
NEURODEVELOPMENTAL TOXICITY
AND ENVIRONMENTAL CONTAMINANTS
IN CALIFORNIA’S RESEARCH AND
REGULATORY PROGRAMS. M. S. Golub1,
2 1
. Office of Environmental Health Hazard
Assessment, California Environmental Protection
Agency, Sacramento, CA and 2Environmental
CA.
#726
7:54
CALIFORNIA’S ASSESSMENT OF THE
IMPACTS OF EARLY IN LIFE EXPOSURE ON
CARCINOGENIC POTENCY. L. Zeise. Cal/EPA,
Office of Environmental Health Hazard Assessment,
Oakland, CA.
#718
7:30
THE PRECAUTIONARY PRINCIPLE:
IMPLICATIONS AND APPLICATIONS. S. G.
Gilbert1 and J. L. Mattsson2. 1INND, Seattle, WA and
2
Dow AgroSciences, Indianapolis, IN.
#719
7:30
AN INTRODUCTION TO THE
PRECAUTIONARY PRINCIPLE. S. G. Gilbert.
INND, Seattle, WA.
#720
7:45
ASPIRATIONS AND LIMITATIONS OF
THE PRECAUTIONARY PRINCIPLE. G. E.
Marchant. Arizona State University College of Law,
Tempe, AZ.
#721
8:00
GREEN CHEMISTRY: DEVELOPING
SUSTAINABLE ALTERNATIVES TO
POLLUTING TECHNOLOGIES. T. Collins.
Carnegie Mellon University, Pittsburgh, PA.
Sponsor: S. Gilbert.
#727
8:03
IMPLEMENTATION OF CALIFORNIA’S
CHILDREN’S ENVIRONMENTAL HEALTH
PROTECTION ACT. M. Marty. Air Toxicology
and Epidemiology Branch, Cal/EPA, OEHHA,
Oakland, CA.
#722
8:15
THE HAZARDS OF THE PRECAUTIONARY
PRINCIPLE. J. L. Mattsson. Human Health
Assessment, Dow AgroSciences, Indianapolis, IN.
#728
8:12
CALIFORNIA’S PUBLIC HEALTH GOALS TO
PROTECT INFANTS AND CHILDREN FROM
DRINKING WATER CONTAMINANTS. A. M.
Fan and R. A. Howd. Office of Environmental Health
Hazard Assessment, California Environmental
Protection Agency, Oakland, CA.
#729
8:21
DEVELOPING CHILD-SPECIFIC
REFERENCE DOSES FOR SCHOOL SITE
ASSESSMENT. D. M. Siegel, S. A. Knadle,
D. Chan and J. Carlisle. OEHHA, Cal/EPA,
Sacramento, CA.
Tuesday, March 7
7:30 AM to 8:50 AM
Room 7B
ROUNDTABLE SESSION: RESEARCH AND DEVELOPMENT OF
CHILD-SPECIFIC PROTECTION IN CALIFORNIA
Chairperson(s): George Alexeeff, CAL EPA, Oakland, CA and Ann de
Peyster, San Diego State University, San Diego, CA.
Tuesday, March 7
8:00 AM to 8:50 AM
Room 6A
Endorsed by:
Risk Assessment SS*
TUESDAY
Recent California laws require child-specific risk assessments to ensure
protection of infants and children as well as other sensitive populations.
Further, several California institutions are conducting research to ascertain infant and child-specific vulnerabilities. Researchers will discuss
recent work on ascertaining developmental vulnerabilities, particularly
those pertaining to the lungs, nervous system, and cancer susceptibility.
Evaluation of child-specific vulnerabilities has lead to the listing of 5
child-specific toxic air contaminants, new guidelines for evaluating air
risk to infants and children and new standards for particulate matter and
ozone. These activities have lead to new proposed guidelines for site mitigation and a reevaluation of water contaminant levels. This symposium
will provide other scientists with information on recent developments in
California.
#723
7:30
RESEARCH AND DEVELOPMENT OF
CHILD SPECIFIC RISK ASSESSMENT IN
CALIFORNIA. G. V. Alexeeff1 and A. de Peyster2.
1
OEHHA, Cal/EPA, Oakland, CA and 2Graduate
School of Public Health, San Diego State University,
San Diego, CA.
#724
7:35
IMPACTS OF ENVIRONMENTAL
CHEMICALS ON THE DEVELOPING LUNG.
C. G. Plopper and M. V. Fanucchi. VM-APC,
University of California, Davis, CA.
MEDICAL RESEARCH COUNCIL (MRC) LECTURE: CELL
DEATH AND NEURODEGENERATION
Lecturer: Junying Yuan, Harvard Medical School, Boston, MA.
The UK Medical Research Council (MRC) sponsored lecture at the SOT
Annual Meeting reflects the long tradition of support by the MRC for basic
sciences and their translation to medicine.
Dr. Junying Yuan will present the MRC lecture on cell
death and neurodegeneration. Dr. Yuan is currently a
professor of Cell Biology at Harvard Medical School.
She initially trained at Fudan University, Shanghai,
China and subsequently obtained her PhD in Neuroscience at Harvard University working with the
Nobel Prize winner H.R. Horvitz. She continued as
an Instructor and Assistant Professor of Medicine at
Harvard Medical School, then became Associate and
now full Professor of Cell Biology. Professor Yuan has pioneered studies
concerning the mechanism of degeneration, regulation and cell death first
in C. elegans and then in mammalian systems and has made fundamental
contributions by discovering the caspase family of proteases and subsequently by relating them to neurodegenerative conditions. More recently
she has used unbiased chemical genetic screens to identify new regulatory
machineries controlling the process leading to cell death. She has identified both new death pathways and chemicals that may be used to prevent
the onset of non-apoptotic cell death. Her work is of great relevance to cell
biology, medicine and toxicology. Dr. Yuan has published an impressive
116
45th Annual
Meeting & ToxExpo
The MRC was established in 1913 and scientists funded by the MRC at its
Units and institutes as well as in several UK universities have discovered
fundamental processes in cell biology and medicine. The MRC supports
research carried out in universities and other academic establishments in
the UK and through its intramural programme supports strategic research
in Units and Institutes. The MRC Toxicology Unit was formed in 1947
and is currently located at the University of Leicester where it integrates
competitive research areas in cell biology, molecular biology, genetics
and medicine. The Unit is pleased to sponsor a lecture at the SOT Annual
Meeting to acknowledge the importance of fundamental sciences and its
medical applications to the field of toxicology.
Tuesday, March 7
8:30 AM to 9:30 AM
Room 11A
inhaled and nasal drug products (OINDP) that are developed for delivery
of drug substance directly to the respiratory or nasal tract to treat either a
respiratory or nasal condition, or a systemic disease. Examples of OINDP
include metered dose inhalers, dry powder inhalers, solutions/suspensions
for nebulization, and nasal sprays. In OINDP, the drug substance is usually
contained in a delivery device that may contain polymers, elastomers, and
other components from which minute quantities of material may migrate
(leach) into the product and be delivered to the sensitive surfaces of the
respiratory and/or nasal tract along with the therapeutic agent. While every
effort is taken to reduce the levels of these leachables, complete removal
is not possible. Because leachables are non-drug-related impurities, there
is an increased concern for human risk by inhaling them on a daily basis.
Historically, acceptable levels of leachables in OINDP have been set by
negotiation with regulatory authorities on a case-by-case basis with no
standard guidelines available. Recently, safety thresholds for risk assessment of leachables have been developed through a joint effort of USFDA,
academia and industry scientists and have addressed current concepts,
background, historical use and development of safety thresholds and their
utility in qualifying leachables in OINDP.
INFORMATIONAL SESSION: BIOLUMINESCENT METHODS
FOR ADME/TOX
#730
9:00
DEVELOPMENT OF SAFETY
QUALIFICATION THRESHOLDS AND THEIR
USE IN DRUG PRODUCT EVALUATION. D.
J. Ball1 and R. O. McClellan2. 1Safety Sciences,
Pfizer, Inc., Groton, CT and 2College of Pharmacy,
University of New Mexico, Albuquerque, NM.
Presented by: Promega Corporation
Bioluminescence offers significant advantages for configuring sensitive,
simple to perform high through-put assays. Bioluminescent systems will be
described that measure the impact of test compounds on xenobiotic metabolizing enzymes, including cytochrome P450s and monoamine oxidase
(MAO), and on the multi-drug transporter (MDR1/Pgp). Each system relies
on the light generating reaction of firefly luciferase. Pgp-GloTM uses luminescence to measure ATP consumption by the Pgp ATPase. P450-GloTM
and MAO-GloTM use a series of selective luminogenic probe substrates for
CYP1A1, 1A2, 1B1, 2C8, 2C9, 2C19, 2D6, 2J2, 3A4, 3A5, 3A7, 4A11 and
4F12 and for MAO A and B. These assays are used to measure inhibition of
recombinant P450s and MAOs and of native enzymes in liver microsomes.
P450-GloTM also provides a novel high throughput method for measuring
P450 gene induction at the P450 enzyme level. This suite of homogeneous
luminescent assays is sensitive, robust and convenient for small scale and
high throughput applications.
#731
9:05
CONCEPT, HISTORY AND APPLICATION OF
SAFETY THRESHOLDS. D. Jacobson-Kram.
Center for Drug Evaluation, U.S. Food and Drug
Administration, Rockville, MD.
#732
9:40
EXTRACTABLES AND LEACHABLES IN
THE PHARMACEUTICAL DEVELOPMENT
PROCESS. D. L. Norwood. Analytical Sciences,
Boehringer Ingelheim Pharmaceuticals, Inc.,
Ridgefield, CT. Sponsor: D. Ball.
#733
10:15
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 2
SAFETY THRESHOLDS FOR LEACHABLES
IN ORALLY INHALED AND NASAL DRUG
PRODUCTS (OINDP). W. Vogel. Safety Sciences,
Pfizer, Inc., Ann Arbor, MI.
#734
10:50
USE OF SAFETY THRESHOLDS IN THE
PHARMACEUTICAL DEVELOPMENT
PROCESS FOR OINDP: AN INDUSTRY
PERSPECTIVE. J. D. Blanchard. Safety
Evaluation, Aradigm Corporation, Hayward, CA.
#735
11:25
USE OF SAFETY THRESHOLDS IN THE
PHARMACEUTICAL DEVELOPMENT
PROCESS FOR OINDP: A REGULATORY
PERSPECTIVE. T. McGovern. Center for Drug
Evaluation, U.S. Food and Drug Administration,
Rockville, MD. Sponsor: D. Ball.
SYMPOSIUM SESSION: DEVELOPMENT OF SAFETY
QUALIFICATION THRESHOLDS AND THEIR USE IN DRUG
PRODUCT EVALUATION
Chairperson(s): Douglas Ball, Pfizer Global Research & Development,
Groton, CT and Roger McClellan, Toxicology and Human Health Risk
Analysis, Albuquerque, NM.
Endorsed by:
Inhalation SS
Risk Assessment SS
Analytical techniques are sophisticated and capable of detecting and identifying chemicals at picogram quantities. However, it is generally accepted
that there are levels of many chemicals below which the risks to human
health are so negligible as to be of no consequence. This rationale has been
the impetus for development of safety thresholds for regulating chemicals
to which humans are exposed. Safety thresholds have a history of use in
regulatory applications, most notably in guidelines for food packaging.
Recently, such thresholds have been developed for application to pharmaceutical drug products. One of these applications is for leachables in orally
117
TUESDAY
number of high-quality papers and is regarded as one of the leading figures
in the research field of cell death.
45th Annual
Meeting & ToxExpo
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 6E
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 8
SYMPOSIUM SESSION: RISK ASSESSMENT AND REGULATORY
IMPLICATIONS OF CONVULSIVE NEUROTOXICITY
SYMPOSIUM SESSION: ROLE OF MITOCHONDRIA IN TOXIC
OXIDATIVE STRESS
Chairperson(s): Mary Kallman, Eli Lilly & Company, Greenfield, IN and
Carrie Markgraf, Schering Plough Research Institute, Lafayette, NJ.
Chairperson(s): Marc Fariss, University of Colorado Health Sciences
Center, Denver, CO and Manisha Patel, University of Colorado, Denver,
CO.
Endorsed by:
Biological Modeling SS
Neurotoxicology SS*
Risk Assessment SS
Endorsed by:
In Vitro SS
Mechanisms SS*
Neurotoxicology SS
This symposium will focus on approaches for developing a risk assessment
around the adverse occurrance of convulsion for a new pharmaceutical
agent. State of the art understanding of non-clinical to clinical modeling of
convulsion and strategies for providing clinical safety will be discussed. A
new perspective on recent interactions with FDA around convulsive liabilities and potential pharmaceutical industry strategies for mitigating the
clinical risk associated with convulsion will be provided.
TUESDAY
#736
9:00
RISK ASSESSMENT AND REGULATORY
IMPLICATIONS OF CONVULSIVE
NEUROTOXICITY. M. J. Kallman1, C. Markgraf2,
G. Schafer4 and J. Arezzo3. 1Pharmacology
Toxicology Research, Lilly Research Labs,
Greenfield, IN, 2Safety Pharmacology, ScheringPlough Res Institute, Lafayette, NJ, 3Neurology,
Albert Einstein University, New York and 4WIL
Research Labs, Ashland, OH.
#737
9:15
PRECLINCIAL SAFETY ASSESSMENT OF
PHARMACEUTICAL CANDIDATES WITH
SEIZURE-GENIC POTENTIAL. C. Markgraf.
Schering Plough Research Institute, Lafayette, NJ.
#738
9:50
NON-INVASIVE EEG MEASURES AS A
PREDICTOR OF SEIZURES. J. C. Arezzo.
Neuroscience and Neurology, Albert Einstein
College of Medicine, Bronx, New York, NY.
Sponsor: C. Markgraf.
#739
10:25
REDUCING ADVERSE CLINICAL RISK
FOR CONVULSION BY UNDERSTANDING
PREMONITORY EVENTS AND POTENTIAL
BIOMARKERS. M. J. Kallman. Pharmacology
Toxicology Research, Lilly Research Labs,
Greenfield, IN.
#740
11:00
Considerable experimental and clinical evidence supports the importance
of mitochondria and mitochondrial oxidative damage as a critical target
and event in toxic oxidative stress-related diseases, including many induced
by toxicants. For example, antioxidants such as vitamin E derivatives
directed to mitochondria have been shown to protect cells against toxic
oxidative stress. Though the critical mitochondrial events responsible for
oxidative stress-mediated cell injury and death (toxic oxidative stress)
have yet to be defined, oxidative damage to mitochondrial lipids, nucleic
acids and proteins appear to be important events in these toxic processes.
The purpose of this Symposium is to report recent experimental evidence
defining how mitochondrial responses to oxidative stress such as mitochondrial cardiolipin oxidation/depletion, persistent mitochondrial DNA
damage and mitochondrial aconitase inactivation can lead to cell injury and
death. With a better understanding of the critical molecular events (targets)
in mitochondria responsible for toxic oxidative stress, we can look forward
to the development of more effective protective therapies.
RISK ASSESSMENT OF CLINICAL SEIZURE
POTENTIAL. A. S. Chappell. Eli Lilly and
Company, Indianapolis, IN. Sponsor: M. Kallman.
118
#741
9:00
ROLE OF MITOCHONDRIA IN TOXIC
OXIDATIVE STRESS. M. W. Fariss1, 2, B.
Van Houten4, M. Patel1, 3 and S. Orrenius5.
1
Pharmaceutical Sciences, University of Colorado
Health Sciences Center, Denver, CO., 2University
of Colorado Cancer Center, University of Colorado
Health Sciences Center, Denver, CO., 3Program
in Neuroscience, University of Colorado Health
Sciences Center, Denver, CO., 4Laboratory
of Molecular Genetics, National Institute of
Environmental Health Sciences, NIH, Research
Triangle Park, NC and 5Institute of Environmental
Medicine, Division of Toxicology, Karolinska
Institutet, Stockholm, Sweden.
#742
9:20
PROTECTIVE ROLE OF MITOCHONDRIAL
VITAMIN E IN TOXIC OXIDATIVE STRESS.
M. W. Fariss. Pharmaceutical Sciences and Cancer
Center, University of Colorado Health Sciences
Center, Denver, CO.
#743
10:00
MITOCHONDRIAL REDOX STATE AND THE
REGULATION OF APOPTOSIS. S. Orrenius.
Institute of Environmental Medicine, Karolinska
Institutet, Stockholm, Sweden.
#744
10:40
ROLE OF MITOCHONDRIAL DNA AND
TELOMERASE IN TOXIC OXIDATIVE
STRESS RESPONSES. B. Van Houten and J. H.
Santos. Laboratory of Molecular Genetics, NIEHS,
NIH, Research Triangle Park, NC. Sponsor: M.
Fariss.
45th Annual
Meeting & ToxExpo
11:20
ROLE OF MITOCHONDRIAL ACONITASE
IN TOXIC OXIDATIVE STRESS. M. Patel.
Pharmaceutical Sciences, University of Colorado
Health Sciences Center, Denver, CO.
#749
10:20
DEVELOPING LIPIDOMICS DATABASES
AND NETWORKS. E. Fahy. Bioinformatics,
UCSD, La Jolla, CA. Sponsor: M. Madden.
#750
10:55
COUNTER-REGULATION OF
INFLAMMATORY RESPONSES BY LIPIDACTIVATED NUCLEAR RECEPTORS. C. K.
Glass. Cellular and Molecular Medicine, UC San
Diego, La Jolla, CA. Sponsor: M. Madden.
#751
11:30
EICOSANOMICS: SIMULTANEOUS
PROFILING OF BIOACTIVE EICOSANOIDS
PRODUCED BY CYCLOOXYGENASE-2. L.
Marnett2 and M. C. Madden1. 1ORD, NHEERL,
HSD, Clinical Research Branch, U.S. EPA,
Chapel Hill, NC and 2A.B. Hancock Jr. Memorial
Laboratory, Vanderbilt Institute of Chemical
Biology, Nashville, TN.
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 1A
WORKSHOP SESSION: COMPREHENSIVE RESPONSES OF
LIPIDS CLASSES TO TOXICANTS AND INVOLVEMENT IN
DISEASES
Chairperson(s): Michael Madden, U.S. EPA, Chapel Hill, NC and Ronald
Riley, USDA, Athens, GA.
Endorsed by:
Mechanisms SS
Along with genes and proteins, lipids are a key component of the cellular
metabolome. Lipids can mediate the induction of some diseases such as
atherosclerosis and also responses to some diseases, e.g., asthma. Pollutants
such as ozone appear to induce biological responses through altered lipid
metabolism. Examining changes in global lipid metabolism, i.e., lipidomics, induced by a pollutant or in a disease state would assist in elucidating
the mechanism(s) of responses. Understanding lipid metabolic changes
would allow assessment of whether the response was of a highly specific or
not, and provide information as to the sensitivity of the lipid measurement,
thereby indicating the usefulness as a biomarker. Inherent in this strategy to
study lipidomics is the ability to 1) possess a knowledge of the metabolism
of 1000 or more lipids in order to optimize lipid study design; 2) measure
the lipids in a specific and quantitative manner, including development of
new methods to analyze newly discovered species; and 3) transfer of the
lipid data to the informatics stage. This session will include presentations
with findings related to the topics discussed above. These topics include
the structural diversity of lipids, methodologies to quantitate lipid species
and classes, how the data from studies examining global changes in lipid
metabolism can be processed to allow interpretation of the findings, and
the use of endotoxin-exposed macrophages in vitro to validate the lipidomics approach. Another topic that will be presented will be the involvement
of oxidized lipids (derived via oxidative stress) in several disease states
(cancer, cardiovascular disease). These topics will be presented by five
researchers of the LIPID MAPS (Metabolite And Pathways Strategy)
Project, which funds investigators at more than 16 academic institutions
and 2 corporations to collaboratively research lipidomics using disciplines
such as cell biology and organic synthesis. [This abstract may not reflect
official EPA policy.]
#746
9:00
COMPREHENSIVE RESPONSES OF
LIPID CLASSES TO TOXIANTS AND
INVOLVEMENT IN DISEASES. M. C. Madden.
ORD, NHEERL, HSD, Clinical Research Branch,
U.S. EPA, Chapel Hill, NC.
#747
9:10
THE LIPID MAPS APPROACH TO
LIPIDOMICS: EICOSANOIDOMICS AND
LIPID CLASSIFICATION. E. A. Dennis.
Chemistry & Biochemistry, and Pharmacology,
University of California, San Diego, La Jolla, CA.
Sponsor: M. Madden.
#748
9:45
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 5B
WORKSHOP SESSION: DISCOVERY TOXICOLOGY:
STRATEGIES IN THE NEW DRUG DISCOVERY PARADIGM
Chairperson(s): Thomas Jones, Eli Lilly & Company, Greenfield, IN and
Vito Sasseville, Millennium Pharmaceuticals, Inc., Cambridge, MA.
Endorsed by:
Drug Discovery SS*
The duration from initial synthesis of a new chemical entity (NCE) to the
delivery of an innovative therapeutic to the patient is becoming longer (912 years) with estimated total costs rapidly approaching $1 billion. The
financial investment grows exponentially as an NCE advances through
the discovery and development process. A major cause of compound
failure during the pre-clinical and clinical development phases is toxicity.
Estimates regarding toxicology-driven attrition during the drug development process range from 20-40%. Therefore, the opportunity exists for
the toxicologist to significantly impact expenditures by the early prediction of potential toxicity/side effect barriers to development by aggressive
evaluation of development limiting liabilities early in drug discovery.
Improved efficiency in pharmaceutical research and development lies
both in leveraging “best in class” technology and integration with pharmacologic and medicinal chemistry activities during hit-to-lead and early
lead optimization stages. This workshop will provide an overview of
the various strategies being applied to integrate toxicology in the drug
discovery process. The presentations will provide a greater understanding
of the causes and timing of toxicology-driven attrition in drug development
and how the discovery toxicologist can better interface with the pharmacologist and medicinal chemist. Topics which will be covered in detail
include in vitro and in vivo screening approaches, the use of high content
technologies (i.e., genomics), in silico approaches to predictive toxicology,
and the application of alternative animal models (transgenic animals, gene
knockdown/knockout models, non-mammalian species, etc.), and finally,
examples of integrated discovery toxicology approaches currently being
used in the industry.
#752
CHALLENGES IN THE ANALYSIS OF
COMPLEX MIXTURES OF LIPIDS PRESENT
IN BIOLOGICAL EXTRACTS. R. C. Murphy.
Pharmacology, University of Colorado, Aurora, CO.
Sponsor: M. Madden.
119
9:00
PREDICTIVE TOXICOLOGY: STRATEGIES
IN THE NEW DRUG DISCOVERY
PARADIGM. T. W. Jones1 and V. G. Sasseville2. 1Eli
Lilly and Company, Greenfield, IN and 2Millennium
Pharmaceuticals, Inc., Cambridge, MA.
TUESDAY
#745
45th Annual
Meeting & ToxExpo
#753
9:05
IN SILICO ADMET, WHO USES IT AND
WHEN? D. Ryan, L. Herman and O. Stradella.
Computational Chemistry, Millennium
Pharmaceuticals, Inc., Cambridge, MA. Sponsor: T.
Jones.
#754
9:40
IN VITRO SCREENING APPROACHES:
APPLICATIONS IN DISCOVERY. J. Xu. Pfizer
Research and Development Center, Cambridge, MA.
#755
10:15
REACTIVE METABOLITES IN DRUG
DISCOVERY AND DEVELOPMENT.
DETECTION, IDENTIFICATION, AND ROLE
IN THE DESIGN OF SAFER DRUGS. T. A.
Baillie. Merck & Co., West Point, PA. Sponsor: T.
Jones.
#756
10:50
APPLICATION OF TOXICOGENOMICS
TOWARDS DRUG SAFETY EVALUATION. J.
F. Waring, Y. Yang, S. Abel and E. Blomme. Abbott
Laboratories, Abbott Park, IL.
#757
11:25
DISCOVERY TOXICOLOGY APPROACHES:
PUTTING STRATEGY INTO PRACTICE. V. G.
Sasseville, J. Lane, V. Kadambi and C. Alden. Drug
Safety Evaluation, Millennium Pharmaceuticals,
Inc., Cambridge, MA.
METABOLISM AND TOXICITIES OF
INORGANIC AND ORGANIC AS SPECIES.
B. D. Beck and A. Schoen. Gradient Corporation,
Cambridge, MA.
#760
9:45
GENOTOXIC PROFILE OF AS, MMA
AND DMA. T. G. Rossman. Nelson Institute of
Environmental Medicine, New York University
#761
10:20
CARCINOGENICITY OF ARSENICALS IN
HUMANS AND ANIMAL MODELS. S. D.
Cohen, L. L. Arnold, M. Cano and T. Ohnishi.
Department of Pathology and Microbiology,
University of Nebraska Medical Center, Omaha, NE.
#762
10:55
EPIDEMIOLOGY AND CLINICAL EFFECTS.
R. Calderon, D. J. Thomas and E. Hudgens.
National Health & Environmental Effects Research
Laboratory, Office of Research & Development,
WORKSHOP SESSION: NEW FOOD INGREDIENTS DO NOT
NEED NEW FOOD REGULATIONS
Chairperson(s): James Griffiths, Burdock Group, Vero Beach, FL and
Thomas Vollmuth, William Wrigley Jr Company, Chicago, IL.
Endorsed by:
Food Safety SS
WORKSHOP SESSION: DOES THE METHYLATION OF
INORGANIC ARSENIC AFFECT ITS TOXICITY AND MODE(S)
OF ACTION? A CRITICAL DISCUSSION
Chairperson(s): Barbara Beck, Gradient Corporation, Cambridge, MA
and Charles Abernathy, Abernathy & Associates, Bristow, VA.
Endorsed by:
Carcinogenesis SS
Metals SS *
Risk Assessment SS
TUESDAY
Considerable controversy exists over the risk assessment of ingested
arsenic (As). Various questions include: 1). Should a linear or a nonlinear risk assessment be employed? 2). Do the inorganic and the organic
(i.e., monomethyl arsonic acid (MMA) and dimethylarsinic acid (DMA))
arsenicals have similar modes of action? and 3). How much weight should
be assigned to the relatively small US studies? In this workshop, the
potential of inorganic As and its various metabolites to cause acute and
chronic effects to humans and in animal models will be described. Of
particular interest will be a contrast of exposures to inorganic As and an
organic arsenical, DMA, and discussion of whether such exposures would
be expected to result in similar or dissimilar toxic effects via the same or
different toxic mechanisms. After considering these questions, the epidemiological data will be evaluated to ascertain how such data can be used
to support the theories put forth concerning As toxicity. At the end of the
workshop, there will be a question and answer session for the attendees.
9:00
9:10
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 1B
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 5A
#758
#759
DOES THE METHYLATION OF INORGANIC
ARSENIC AFFECT ITS TOXICITY AND
MODE(S) OF ACTION? A CRITICAL
DISCUSSION. C. Abernathy. Abernathy Associates,
Bristow, VA.
Consumer demands for newer and better foods puts considerable pressure on food technicians, and the food industry as a whole, to satisfy this
demand for an endless supply of novel food ingredients. Recent developments in ‘fad diets’ and functional claims (i.e., structure function and
health) have unlocked new dimensions in food ingredient development.
Ingredients never before used or contemplated, such as low carbohydrate
starches, new artificial sweeteners, unusual vegetable oils, pre- and probiotic bacteria, and botanical extracts, are now the subjects of intense
investigation and development. Adequate demonstration of safety must
be driven, by the regulations in place, so that each new ingredient is not
evaluated in a de novo or case-specific fashion. The current food ingredient
regulations are able to examine macronutrients, modified carbohydrates,
oils and proteins, functional (to the human body) ingredients, novel botanical extracts, and competitive bacteria for safety-in-use as a food ingredient.
The safety of the food containing a new ingredient can be addressed;
however, the role of an individual over-consuming a disproportionate
amount of a singular food or food type, i.e., ‘macrofoods/macronutrients,
’ can only be handled by modifications to exposure patterns. Definitions
and regulatory status of nutrients, fortificants, functional, and medical
foods will be discussed. Additionally, qualified and un-qualified health
claims on these and other food ingredients are driving the need to establish
efficacy via robust and well-designed clinical studies. Even with these
studies in support of the safety and efficacy to human test populations, an
adverse event reporting system needs to consider the long-term monitoring
of sensitive subpopulations, over-consumption, alternative uses, drug/food
interactions, nutrigenomics etc. Finally, the breadth of novel ingredients
entering the food supply, and their assessment for safety under the aegis of
current regulatory paradigms will be discussed.
120
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#764
9:00
9:15
NEW FOOD INGREDIENTS DO NOT NEED
NEW FOOD REGULATIONS. J. C. Griffiths1,
J. A. Thomas5, J. F. Borzelleca3, I. G. Carabin4, R.
A. Matulka1 and A. S. Persad1. 1Burdock Group,
Washington, DC, 2Office of Food Additives Safety,
Food and Drug Administration, College Park, MD,
3
Department of Pharmacology and Toxicology,
Virginia Commonwealth University, Richmond, VA,
4
Women Health Sciences Institute, Vero Beach, FL
and 5Department of Pharmacology and Toxicology,
Indiana University, Indianapolis, IN.
model to test more complex chemicals and product formulations, there is a
desire to advance the LLNA to evaluate a larger variety of materials. This
workshop will consider how the LLNA has fared in its use as a stand-alone
predictor of dermal sensitization potential, including presentation of experimentation that has been evaluated to increase the utility of this model.
DRUG-NUTRIENT INTERACTIONS
- RECOGNIZING PHARMACOLOGIC
IMPLICATIONS. J. A. Thomas. Department of
Pharmacology and Toxicology, Indiana University,
Fishers, IN.
#769
9:00
REGULATORY APPLICATION OF THE
MOUSE LLNA: NEW CHALLENGES AND
OPPORTUNITIES. G. S. Ladics2 and M. R.
Woolhiser1. 1Toxicology & Environmental Research
Midland, MI and 2DuPont Haskell Laboratories,
Newark, DE.
#770
9:05
PERFORMANCE AND VALIDATION OF THE
LOCAL LYMPH NODE ASSAY. I. Kimber.
Syngenta Central Toxicology Laboratory, Cheshire,
United Kingdom.
#771
9:40
REGULATORY EXPERIENCE OF TESTING
NEW, INDUSTRIAL CHEMICALS WITH THE
LLNA. A. Cockshott. Health and Safety Executive,
Bootle, United Kingdom. Sponsor: M. Woolhiser.
#772
10:15
CONSIDERATIONS FOR
PHARMACEUTICAL PRODUCTS AND THE
LOCAL LYMPH NODE ASSAY (LLNA). A.
Jacobs. CDER, U.S. Food and Drug Administration,
Rockville, MD.
#765
9:48
MACRONUTRIENTS AND
MACRONUTRIENT SUBSTITUTES IN
TODAY’S DIETS. J. F. Borzelleca. Pharmacology
and Toxicology, Virginia Commonwealth University,
Richmond, VA.
#766
10:21
FORTIFICANTS, NUTRIENTS, MEDICAL
AND FUNCTIONAL FOODS: THE ALPHABET
SOUP. A. Mattia. U.S. FDA/CFSAN, College Park,
MD. Sponsor: J. Griffiths.
#767
10:54
CLINICAL DATA AS A NEW REQUIREMENT
FOR FOOD INGREDIENT SAFETY. I. Carabin.
Women’s Health Sciences Institute, Vero Beach, FL.
Sponsor: J. Griffiths.
#773
10:50
APPLICATION OF LLNA DATA IN SKIN
SENSITIZATION RISK ASSESSMENT. G.
Gerberick. Miami Valley Laboratories, Procter &
Gamble Company, Cincinnati, OH.
#768
11:27
SAFETY EVALUATION OF A NOVEL
INGREDIENT: PROBIOTIC AND NONPROBIOTIC BACTERIA ADDED TO FOOD. R.
A. Matulka. Burdock Group, Vero Beach, FL.
#774
11:25
LLNA EXPERIENCE FOR COMPLEX
CHEMISTRIES AND MIXTURES. M. R.
Woolhiser. Toxicology & Environmental Research
Midland, MI.
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 7B
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 6C
WORKSHOP SESSION: REGULATORY APPLICATION OF THE
MOUSE LLNA: NEW CHALLENGES AND OPPORTUNITIES
PLATFORM SESSION: AH RECEPTOR III
Chairperson(s): Michael Woolhiser, Dow Chemical Company, Midland, MI
and Gregory Ladics, DuPont Haskell Laboratories, Wilmington, DE.
FL and Robert Tukey, University of California San Diego, LaJolla, CA.
Endorsed by:
Dermal Toxicology SS
Immunotoxicology SS*
Since 2002, adoption of the mouse Local Lymph Node Assay (LLNA) as
a stand-alone test to evaluate dermal sensitization potential for industrial
chemicals occurred globally (e.g., U.S. EPA OPPTS 870.2600 & OECD
TG 429). The LLNA is now endorsed internationally as the preferred, and
in some cases mandated, approach replacing the Magnusson and Kligman
(M&K) Maximization and Buehler guinea pig methods due to animal
welfare benefits, and the use of more objective and quantitative measurements. Moreover, the LLNA lends itself more readily to assess the relative
potency of skin sensitizers. This aspect has led to proposals of the LLNA as
a possible addition to risk assessment schemes. While years of evaluation
using purified, characterized chemicals have suggested the LLNA is overall
slightly more accurate than guinea pig tests, its effectiveness at testing
novel chemicals since its broad acceptance is beginning to be evaluated.
There is little to no published data on the testing of materials such as polymers or complex chemical mixtures. With the objective of using the same
121
#775
9:00
FUNCTIONAL ANALYSIS OF ARNT2 IN
AH RECEPTOR-MEDIATED SIGNAL
TRANSDUCTION. E. J. Dougherty and R. S.
Pollenz. Biology, University of South Florida,
Tampa, FL.
#776
9:20
FUNCTIONAL ANALYSIS OF THE
TCDD-INDUCIBLE CYP1A1 PROMOTER/
ENHANCER REGION FROM ZEBRAFISH
(DANIO RERIO). G. ZeRuth and R. S. Pollenz.
Biology, University of South Florida, Tampa, FL.
#777
9:40
TRANSCRIPTIONAL REGULATION OF IL-8
BY AH-RECEPTOR ACTIVATION. C. Vogel1,
E. Sciullo1, P. Wong1, L. Wen1, G. Lazennec2 and
F. Matsumura1. 1ETOX, UC Davis, Davis, CA and
2
Molecular and Cellular Endocrinology, INSERM,
Montpellier, France.
TUESDAY
#763
45th Annual
Meeting & ToxExpo
#778
10:00
CHRYSIN INDUCES HUMAN UGT1A1
BY A NON-CLASSICAL Ah RECEPTOR
MECHANISM. J. A. Bonzo, M. Yueh, S. Chen
and R. H. Tukey. Laboratory of Environmental
Toxicology, Departments of Pharmacology and
Chemistry & Biochemistry, University of California
San Diego, La Jolla, CA.
#779
10:20
(AHR) INFLUENCES THE OXYGENREGULATION OF ENDOTHELIN-1
EXPRESSION AND MODULATES THE
DEVELOPMENT OF HYPERTENSION. M.
K. Walker1, G. Fink2 and A. K. Lund1. 1College of
Pharmacy, University of New Mexico, Albuquerque,
NM and 2Pharmacology and Toxicology, Michigan
#780
10:40
ANALYSIS OF GENE EXPRESSION PROFILE
IN BRONCHIAL EPITHELIAL CELLS
IN RESPONSE TO DIESEL EXHAUST
PARTICLES EXPOSURE USING CDNA
MICROARRAY. J. Wan and D. Diaz-Sanchez. CIA,
UCLA, Los Angeles, CA. Sponsor: M. Whitekus.
#781
11:00
DOWN-REGULATION IN HEPATIC GENE
EXPRESSION WITHIN 6H OF EXPOSURE
TO TCDD. B. J. Ovando1, C. M. Vezina2 and J. R.
Olson1. 1Pharmacology & Toxicology, University at
Buffalo, Buffalo, NY and 2Pharmacy, University of
Wisconsin, Madison, WI.
#782
#783
11:20
11:40
GENOME-WIDE ANALYSIS OF TCDDMEDIATED PROMOTER BINDING OF
THE ARYL HYDROCARBON RECEPTOR.
J. Burt, E. Dere, L. Burgoon and T. Zacharewski.
Biochemistry & Molecular Biology, Center for
Integrative Toxicology, and National Food Safety &
Lansing, MI.
TUESDAY
A NEW ROLE FOR THE ARYL
HYDROCARBON RECEPTOR IN
REGULATING GENE EXPRESSION. J. A.
Schwanekamp and C. R. Tomlinson. Env. Health,
University of Cincinnati, Cincinnati, OH.
#785
9:22
MONITORING CHOLINESTERASES:
AN EXAMPLE OF TRANSLATIONAL
RESEARCH. B. W. Wilson, V. Nihart, J. D.
Henderson, A. Ramirez and D. E. Arrieta.
Davis, CA.
#786
9:44
IDENTIFICATION OF BIOMARKERS
FOR EXPOSURE OF FATHEAD MINNOW
TO 2, 4-DINITROTOLUENE USING CDNA
MICROARRAYS - CORRELATION WITH
CLINICAL SYMPTOMS IN MAMMALS. H.
Wintz1, L. Yoo2, J. A. Steevens2, A. B. Gibson2,
E. J. Perkins2, C. D. Vulpe1 and A. Loguinov1.
1
Nutritional Sciences and Toxicology, UC-Berkeley,
Berkeley, CA and 2USACE Engineer Research and
Development Center, Vicksburg, MS.
#787
10:06
CYP1A1 INDUCTION AND ARYL
HYDROCARBON RECEPTOR ACTIVATION:
DEATH PENALTY FOR PRE-CLINICAL
DRUG CANDIDATE? C. Sorrentino1, W. Hu2,
M. Denison1 and M. R. Fielden2. 1Department of
Davis, CA and 2Iconix Pharmaceuticals, Mountain
View, CA.
#788
10:28
A FIRST STEP TOWARDS THE VALIDATION
OF PRE-CLINICAL SAFETY BIOMARKERS.
F. Dieterle1, F. Staedtler1, S. Chibout1, A. Cordier1,
M. DeCristofaro2, P. Grass1, O. Grenet1, R.
Hillenbrand1, M. Kammueller1, F. Legay1, J. A.
Mahl1, R. Papoian1, E. Perentes1, D. R. Roth1,
D. Wahl1, A. Zaar1 and G. Maurer1. 1BioMarker
Development, Novartis, Basel, Switzerland and
2
Novartis, East Hannover, NJ.
#789
10:50
LIMITED ADDITIONAL RELEASE
OF CARDIAC TROPONINS I AND T IN
ISOPROTERENOL TREATED BEAGLE DOGS
WITH CARDIAC INJURY. X. Feng, P. Taggart, L.
Hall, S. Bryant, J. Sansone, M. Kemmerer, J. Herlich
and P. Lord. Johnson & Johnson PRD, Raritan, NJ.
#790
11:12
IDENTIFICATION OF THREE MAJOR
DNA ADDUCTS FORMED BY THE
CARCINOGENIC AIR POLLUTANT 3NITROBENZANTHRONE IN RAT LUNG AT
THE C8 AND N2 POSITION OF GUANINE
AND AT THE N6 POSITION OF ADENINE. V.
Arlt1, H. H. Schmeiser2, M. Kawanishi3, T. Kanno3,
T. Yagi3, T. Takamura-Enya4 and D. H. Phillips1.
1
Institute of Cancer Research, Sutton, Surrey,
United Kingdom, 2German Cancer Research Center,
Heidelberg, Germany, 3Osaka Prefecture University,
Osaka, Japan and 4National Cancer Center Research
Institute, Tokyo, Japan. Sponsor: S. Mueller.
#791
11:34
SEARCH FOR CANDIDATE PROTEIN
BIOMARKERS FOR PBDES TOXICITIES.
S. Jeong, H. Pyo, E. Kim, H. Ku, H. Kang, S. Son
and J. Cho. Toxicology Division, NVRQS, Anyang,
Kyunggi, South Korea.
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 15A
PLATFORM SESSION: BIOMARKERS: IDENTIFICATION AND
APPLICATION
Chairperson(s): Barry Wilson, University of California Davis, Davis, CA
and Sang-Hee Jeong, NVRQS, Anyang, Kyunggi, South Korea.
#784
9:00
VALIDATION OF PUTATIVE BIOMARKERS
FOR THE EARLY PREDICTION OF NONGENOTOXIC HEPATOCARCINOGENESIS
AND COMPARISON TO DRUG SIGNATURES.
M. R. Fielden and R. Brennan. Iconix
Pharmaceuticals, Mountain View, CA.
122
45th Annual
Meeting & ToxExpo
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 6F
#798
11:00
ACUTE TOXICITY OF ACETALDEHYDE
ON ALDEHYDE DEHYDROGENASE 2
GENE TARGETING MICE: 5000PPM 4H
INHALATION STUDY. T. Isse1, T. Oyama1,
K. Naoki2, K. Matsuno3, M. Ogawa1, T. Kinaga1,
T. Murakami1, T. Yamaguchi1, K. Kitagawa4, I.
Uchiyama5 and T. Kawamoto1. 1Environmental
Health, University of Occupational and
Environmental Health, Kitakyushu, Japan,
2
Health Science, University of Occupational
and Environmental Health, Kitakyushu, Japan,
3
Bio-information Research Center, University
Kitakyushu, Japan, 4First Department of
Biochemistry, University of Occupational and
Environmental Health, Hamamatsu, Japan and
5
Environmental Hygiene, School of Technology,
Kyoto University, Kyoto, Japan.
#799
11:20
CHINESE HAMSTER OVARY CELLS
EXPRESSING CYP1A1 OR CYP1A2 AND
RAPID OR SLOW ACETYLATOR NACETYLTRANSFERASE 1 (NAT1): A MODEL
TO INVESTIGATE EFFECTS OF HUMAN
NAT1 POLYMORPHISM ON ARYLAMINE
GENOTOXICITY. J. Bendaly, S. Zhao, M. A.
Doll, J. States and D. W. Hein. Pharmacology &
Toxicology and Brown Cancer Center, University of
#800
11:40
2-AMINO-1-METHYL-6-PHENYLIMIDAZO
[4, 5-B] PYRIDINE (PHIP)-INDUCED
DNA ADDUCTS IN CHINESE HAMSTER
OVARY (CHO) CELLS EXPRESSING
HUMAN CYP1A2 AND RAPID AND SLOW
N-ACETYLTRANSFERASE 2 (NAT2). K. J.
Metry, S. Zhao, J. R. Neale, M. A. Doll, J. States,
W. McGregor, W. M. Pierce and D. W. Hein.
Pharmacology & Toxicology and Brown Cancer
Center, University of Louisville, Louisville, KY.
PLATFORM SESSION: GENETIC POLYMORPHISMS
Chairperson(s): Sherif Abdel-Rahmen, University of Medicine and
Dentistry of New Jersey, Newark, NJ and Andrew Smith, University of
Leicester, Leicester, United Kingdom.
#792
9:00
GENETIC POLYMORPHISMS OF HUMAN
N-ACETYLTRANSFERASE 2 INFLUENCE
THE BIOACTIVATION OF AROMATIC AND
HETEROCYCLIC AMINES. Y. Zang, M. A.
Doll, J. States and D. W. Hein. Pharmacology &
Toxicology and Brown Cancer Center, University of
#793
9:20
N-ACETYLTRANSFERASE 2 (NAT2)
GENOTYPE DEPENDENT METABOLIC
ACTIVATION OF N-HYDROXY ARYLAMINE
CARCINOGENS IN CRYOPRESERVED
HUMAN HEPATOCYTES. M. A. Doll1, N.
S. Jensen2 and D. W. Hein1. 1Pharmacology &
Toxicology and Brown Cancer Center, University
of Louisville, Louisville, KY and 2In Vitro
Technologies, Baltimore, MD.
#794
#795
#796
#797
9:40
10:00
10:20
10:40
QUANTIFICATION OF 4-AMINOBIPHENYL
DNA ADDUCTS IN RAPID AND SLOW
ACETYLATOR RATS BY LIQUID
CHROMATOGRAPHY-TANDEM MASS
SPECTROMETRY. J. R. Neale, N. B. Smith, W. M.
Pierce and D. W. Hein. Pharmacology & Toxicology
and Brown Cancer Center, University of Louisville,
Louisville, KY.
DETERMINATION OF THE SENSITIVITY
OF CURRENT MUTATION DETECTION
METHODOLOGIES THROUGH THE
USE OF THE NIST HETEROPLASMIC
MITOCHONDRIAL DNA STANDARD
REFERENCE MATERIAL 2394. B. C. Levin.
Biotechnology Division, National Institute of
Standards and Technology, Gaithersburg, MD.
Tuesday, March 7
9:00 AM to 12:00 NOON
Room 7A
NORMAL LIVER AND SPLEEN IRON STATUS
ARE UNDER MULTIGENIC CONTROL. A. G.
Smith1, G. R. Grant1, S. Robinson1, R. E. Edwards1,
R. Davies1, D. J. Judah1 and K. W. Broman2. 1MRC
Toxicology Unit, University of Leicester, Leicester,
United Kingdom and 2Department of Biostatistics,
Johns Hopkins Medical School, Baltimore, MD.
PLATFORM SESSION: IN VITRO AND IN VIVO RESPONSES TO
SMOKE
Chairperson(s): Laura Van Winkle, University of California Davis, Davis,
CA and Judith Zelikoff, New York University School of Medicine, Tuxedo,
NY.
A PHARMACOGENOMIC APPROACH FOR
ANTICOAGULATION THERAPY: EFFECT OF
POLYMORPHISMS IN THE MICROSOMAL
EPOXIDE HYDROLASE (MEH) GENE ON
WARFARIN-DOSE REQUIREMENT AND
METABOLISM. C. Kinslow, M. M. Xue, H.
vonMarrensdorff, C. Lee, C. C. Hallberg, C. E. Hill,
K. J. Wolfe and S. Abdel-Rahman. UTMB, Galveston,
TX.
123
#801
9:00
MODULATION OF GAS-VAPOR PHASEINDUCED CYTOTOXICITY FROM 2R4F
KENTUCKY REFERENCE CIGARETTE.
J. T. Hamm and J. D. Johnson. Lorillard Tobacco
Company, Greensboro, NC.
#802
9:25
IMPAIRMENT OF LUNG CELL ENERGETICS
BY TETRAHYDROCANNABINOL IN VIVO. T.
A. Sarafian1, L. Lin1, M. Oldham2, D. P. Tashkin1 and
M. D. Roth1. 1Medicine, UCLA, Los Angeles, CA
and 2Community and Environmental Medicine, UC
Irvine, Irvine, CA.
TUESDAY
45th Annual
Meeting & ToxExpo
#803
9:50
PEROXIREDOXIN-6 IS DECREASED IN
BOTH MALE AND FEMALE ADULT MOUSE
AIRWAYS BY EXPOSURE TO TOBACCO
SMOKE. L. S. Van Winkle1, G. L. Baker2 and K. M.
Sutherland1. 1VM:APC/CHE, UC Davis, Davis, CA
and 2Battelle, Richland, WA.
#804
10:15
IN UTERO EXPOSURE TO ENVIRONMENTAL
TOBACCO SMOKE (ETS) CAN POTENTIATE
SENSITIZATION OR TOLERIZATION TO
AEROALLERGEN. A. Penn1, R. Rouse1, D.
Paulsen2, L. Lomax2, M. Kearney2 and D. Horohov3.
1
CBS, LSU School of Vet. Med., Baton Rouge, LA,
2
Pathobiol. Sciences., LSU School of Vet. Med.,
Baton Rouge, LA and 3Vet. Sciences, University of
KY, Lexington, KY.
#805
10:40
EFFECT OF EXPOSURE PATTERN ON
CIGARETTE SMOKE-INDUCED LUNG
INFLAMMATION. T. F. Schuessler1, N. Ferrari2,
M. Fortin2 and L. Paquet2. 1SCIREQ Scientific
Respiratory Equipment Inc., Montréal, QC, Canada
and 2Topigen Pharmaceuticals Inc., Montréal, QC,
Canada. Sponsor: D. Bhalla.
#806
11:05
SHORT-TERM CIGARETTE SMOKE
EXPOSURE POTENTIATES ENDOTOXININDUCED PULMONARY INFLAMMATION.
G. S. Kulkarni, P. P. Nadkarni, J. M. Cerreta and J.
O. Cantor. Pharmacy and Allied Health Professions,
St John’s University, New York. Sponsor: L.
Trombetta.
#807
11:30
PERCUTANEOUS ABSORPTION OF
RETINOL IN FUZZY RAT (IN VIVO AND IN
VITRO) AND HUMAN SKIN (IN VITRO) FROM
COSMETIC VEHICLES. J. J. Yourick1, C. T. Jung2
and R. L. Bronaugh1. 1CFSAN/Office of Cosmetics
and Colors, USFDA, Laurel, MD and 2CDER/Office
of Generic Drugs, USFDA, Rockville, MD.
#811
TRITIATED WATER PERMEABILITY AS AN
INDICATOR OF BARRIER INTEGRITY OF
IN VITRO HUMAN AND PIG SKIN USED IN
FRANZ CELLS. M. L. Jovanovic, J. M. McMahon
and S. D. Crofoot. Dow Corning Corporation,
Midland, MI.
#812
A PHYSIOLOGICALLY BASED
PHARMACOKINETIC MODEL OF
PARATHION DERMAL ABSORPTION. D.
van der Merwe, J. D. Brooks, R. Gehring, R. E.
Baynes, N. A. Monteiro-Riviere and J. E. Riviere.
Center for Chemical Toxicology Research and
Pharmacokinetics, North Carolina State University,
Raleigh, NC.
#813
IN-VITRO HUMAN SKIN PENETRATION OF
THE FRAGRANCE MATERIAL GERANYL
NITRILE. S. Bhatia1, J. Lalko1, A. Api1, K. Brain2
and D. Green2. 1Research Institute for Fragrance
Materials Inc., Woodcliff Lake, NJ and 2AN-EX,
Cardiff, United Kingdom.
#814
ABSORPTION FROM CONTAMINATED
SOIL INTO SKIN AND SILICONE RUBBER
MEMBRANES. S. E. Deglin1, D. L. Macalady1
and A. L. Bunge2. 1Chemistry, Colorado School of
Mines, Golden, CO and 2Chemical Engineering,
Colorado School of Mines, Golden, CO. Sponsor:
M. Dellarco.
#815
IN VITRO DERMAL ABSORPTION RATE
TESTING OF METHYL FORMATE. T. R.
Barfknecht1 and W. J. Fasano2. 1EHSA, Celanese.
Ltd., Dallas, TX and 2Haskell Laboratory, E. I. Du
Pont de Nrmours and Company, Newark, DE.
#816
IMPACT OF ALCOHOL CONSUPTION ON
THE SKIN AS DETERMINED BY NONINVASIVE BIOENGINEERING TOOLS. R.
Brand, J. L. Jendrzejewski and A. R. Charron.
Department of Medicine, Evanston Northwestern
Healthcare Research Institute, Evanston, IL.
GENDER AND STRAIN DIFFERENCES
IN TOBACCO SMOKE-INDUCED
INFLAMMATION. Y. Shen and K. E. Pinkerton.
Center for Health and the Environment, University
of California, Davis, Davis, CA.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: DERMATOTOXICITY
TUESDAY
#810
Chairperson(s): Jim Riviere, North Carolina State University, Raleigh, NC
Lori White, Rutgers University, New Brunswick, NJ.
#808
DERMAL EXPOSURE TO PROPICONAZOLE
AMONG FARM WORKERS. S. Flack1, I.
Goktepe2, L. M. Ball1 and L. A. Nylander-French1.
1
of North Carolina at Chapel Hill, Chapel Hill,
NC and 2North Carolina A&T State University,
Greensboro, NC.
#817
WOUND HEALING FOLLOWING
ELECTROPORATION THERAPY IN A
PORCINE MODEL. J. B. Ulreich1, Z. A. Filip1,
D. P. Speer1, M. J. Demeure1, A. V. Valles1, J. B.
Ledesma1, N. B. Dev2, P. M. Goldfarb2 and D. P.
Rabussay2. 1Surgery, University Arizona, Tucson, AZ
and 2Inovio Biomedical Corp., San Diego, CA.
#809
IN VITRO DERMAL ABSORPTION OF
PYRETHROID PESTICIDES IN RAT AND
HUMAN SKIN. M. F. Hughes and B. C. Edwards.
ORD/NHEERL, U.S. EPA, Research Triangle Park,
NC.
#818
COMPARATIVE SENSITIVITY OF TWO
IN VIVO METHODS FOR ASSAYING
PHOTOTOXIC AGENTS. D. B. Learn1, C. P.
Sambuco1, M. Arocena1, T. Coston1, H. Beasley1,
P. D. Forbes1 and A. M. Hoberman2. 1Center for
Photobiology, Charles River Laboratories Preclinical
Services, Horsham, PA and 2Charles River
Laboratories, Horsham, PA.
124
45th Annual
Meeting & ToxExpo
#819
QUANTITATIVE AND TEMPORAL
DIFFERENCES IN UVR DOSE-DEPENDENT
SKIN RESPONSES IN RODENTS (MICE,
RATS AND GUINEA PIGS). C. P. Sambuco1, P.
D. Forbes1, D. B. Learn1, M. Arocena1, T. Coston1,
H. Beasley1 and A. M. Hoberman2. 1Center for
Photobiology, Charles River Laboratories Preclinical
Services, Horsham, PA and 2Charles River
Laboratories Preclinical Services, Horsham, PA.
#826
FULLERENE-BASED AMINO ACID (BAA)
INTERACTIONS IN HUMAN EPIDERMAL
KERATINOCYTES. J. G. Rouse1, A. R.
Barron2, J. Yang2 and N. A. Monteiro-Riviere1.
1
Raleigh, NC and 2Department of Chemistry and
Center for Nanoscale Science and Technology, Rice
University, Houston, TX.
#820
ETIOLOGY OF 8-METHOXYPSORALEN
PHOTOTOXICITY IN MOUSE SKIN IS
DEPENDENT ON VEHICLE, EXPOSURE
TIME AND ADMINISTRATION SITE.
G. L. DeGeorge. MB Research Laboratories,
Spinnerstown, PA.
#827
#821
MORPHOLOGICAL CORRELATES OF
PLATELET ACTIVATING FACTOR -INDUCED
DEGRANULATION OF ISOLATED MAST
CELLS. C. M. wessely2, J. P. petrali2, A. A.
Brimfield1 and H. A. tracey2. 1pharmacology branch,
USAMRICD, APG/EA, MD and 2comparitive
Medicine division, USAMRICD, APG/EA, MD.
SKIN PENETRATION OF FULLERENE
SUBSTITUTED AMINO ACIDS AND THEIR
INTERACTIONS WITH HUMAN EPIDERMAL
KERATINOCYTES. N. A. Monteiro-Riviere1, J.
Yang2, A. O. Inman1, J. Ryman-Rasmussen1, A. R.
Barron2 and J. E. Riviere1. 1Center for Chemical
Toxicology Research and Pharmacokinetics,
North Carolina State University, Raleigh, NC and
2
Department of Chemistry and Center for Nanoscale
Science and Technology, Rice University, Houston,
TX.
#828
SKIN PENETRATION, CELLULAR UPTAKE,
CYTOTOXICITY, AND INFLAMMATORY
POTENTIAL OF QUANTUM DOTS. J. P. RymanRasmussen, J. E. Riviere and N. A. Monteiro-Riviere.
Raleigh, NC.
#829
POLYMER STANDARDS FOR
QUANTITATION OF QUANTUM DOTS IN
TISSUE. D. W. Roberts1, N. V. Gopee1, A. R.
Warbritton2, W. W. Yu4, V. L. Colvin4, N. J. Walker3
and P. C. Howard1. 1Biochemical Toxicology, NCTR,
Jefferson, AR, 2Toxicological Pathology Associates,
Jefferson, AR, 3National Toxicology Program,
NIEHS, Research Triangle Park, NC and 4Rice
University, Houston, TX.
#830
INTERACTION OF NANOMATERIALS WITH
MOUSE KERATINOCYTES. C. Amato3, S.
Hussain1, K. Hess2 and J. Schlager1. 1Air Force
Research Laboratory, Mantech Environment,
Wright-Patterson AFB, OH, 2Geo-Center Inc.,
Wright-Patterson AFB, OH and 3Oak Ridge Institute
for Science and Education, Oak Ridge, OH.
#831
PARAQUAT ALTERS EXPRESSION OF
ARACHIDONIC ACID METABOLIZING
ENZYMES AND HEME OXYGENASE1 (HO-1) IN PRIMARY CULTURES OF
MOUSE KERATINOCYTES. A. T. Black1,
M. P. Shakarjian3, J. P. Gray2, V. Mishin2, M.
Thiruchelvam4, D. A. Cory-Slechta4, D. E. Heck1, 2
and J. D. Laskin1, 4. 1Toxicology, Rutgers University,
Piscataway, NJ, 2Pharmacology-Toxicology, Rutgers
University, Piscataway, NJ, 3Medicine, UMDNJRWJMS, Piscataway, NJ and 4Environment &
Occupation Med., UMDNJ-RWJMS, Piscataway, NJ.
#832
2, 3, 7, 8-TETRACHLORODIBENZO-p-DIOXIN
INDUCED MATRIX METALLOPROTEINASE
EXPRESSION IN A2058 MELANOMA CELLS.
K. A. Murphy and L. A. White. Joint Graduate
Program of the Molecular Biosciences, Joint
Graduate Program in Biochemistry, Department of
Biochemistry and Microbiology, Rutgers University,
New Brunswick, NJ.
#822
#823
#824
#825
EXTRACTION PROCEDURE OF TATTOO
PIGMENTS FROM SKIN. E. Engel2, W.
Baumler1, T. Maisch1, H. Ulrich1, B. Konig2, M.
Landthaler1, N. V. Gopee3, P. C. Howard3 and R.
Vasold2. 1Dermatology, University of Regensburg,
Regensburg, Germany, 2Organic Chemistry,
University of Regensburg, Regensburg, Germany
and 3Biochemical Toxicology, NCTR, Jefferson, AR.
TRACE ANALYSIS OF NANO-C60 IN
BIOLOGICAL MEDIA BY LIQUID-LIQUID
EXTRACTION AND HIGH-PERFORMANCE
LIQUID CHROMATOGRAPHY. X. R. Xia1, N.
A. Monteiro-Riviere1, C. M. Sayes2, V. L. Colvin2
and J. E. Riviere1. 1Center for Chemical Toxicology
Research and Pharmacokinetics, North Carolina
State University, Raleigh, NC and 2Department
of Chemistry & Center for Biological and
Environmental Nanotechnology, Rice University,
Houston, TX.
MULTI-WALLED CARBON NANOTUBE
EXPOSURE IN HUMAN KERATINOCYTES
ALTERS PROTEIN EXPRESSION. F.
Witzmann1, D. Hong1, A. O. Inman2, J. E. Riviere2,
R. J. Neimanich3, Y. Wang3 and N. A. MonteiroRiviere2. 1Cellular & Integrative Physiology, Indiana
University School of Medicine, Indianapolis, IN,
2
Raleigh, NC and 3Department of Physics, North
Carolina State University, Raleigh, NC.
NANOC60 AND DERIVATIZED C60 TOXICITY
IN HUMAN EPIDERMAL KERATINOCYTES.
A. O. Inman1, C. M. Sayes2, V. L. Colvin2 and N. A.
Monteiro-Riviere1. 1Center for Chemical Toxicology
State University, Raleigh, NC and 2Department
of Chemistry & Center for Biological and
Environmental Nanotechnology, Rice University,
Houston, TX.
125
TUESDAY
45th Annual
Meeting & ToxExpo
#833
2, 3, 7, 8-TETRACHLORODIBENZO-p-DIOXIN
INHIBITS EXPRESSION OF THE INHIBITOR
OF DNA BINDING (ID) -1 AND -3 IN NORMAL
HUMAN FIBROBLASTS. A. Akintobi, C. Villano
and L. White. Biochemistry and Microbiology,
Rutgers, The State University of New Jersey, New
Brunswick, NJ.
#834
EFFECTS OF EXOGENOUS AND
ENDOGENOUS AHR ACTIVATION ON
GENES CONTROLLING CELL FATE AND
DIFFERENTIATION IN HUMAN EPIDERMAL
CELL TYPES. L. M. Van Pay1 and B. AllenHoffmann1, 2. 1Molecular and Environmental
Toxicology, University of Wisconsin, Madison, WI
and 2Pathology and Laboratory Medicine, University
of Wisconsin, Madison, WI.
#835
GENE EXPRESSION PROFILES IN
TATTOOED SKIN OF SKH-1 HAIRLESS
MICE. N. V. Gopee1, 2, V. G. Desai1, B. J. Miller1, 2,
J. C. Fuscoe1, W. Tong1, H. Fang1, W. G. Wamer3 and
P. C. Howard1, 2. 1NCTR, USFDA, Jefferson, AR,
2
NTP Center for Phototoxicology, NCTR, USFDA,
Jefferson, AR and 3CFSAN, USFDA, College Park,
MD.
TUESDAY
#836
GENE EXPRESSION IN RAT SKIN AFTER
BRIEF CUTANEOUS EXPOSURE TO JP8 AND FOUR COMPONENTS OF JP-8. J.
N. McDougal and C. M. Garrett. Department
of Pharmacology and Toxicology, Wright State
University, Dayton, OH.
#837
REAL-TIME PCR CONFIRMATION OF
CHANGES IN GENE EXPRESSION IN
RAT EPIDERMIS AFTER JET FUEL (JP8) EXPOSURE TO THE SKIN. C. M. Amato,
C. M. Garrett and J. N. McDougal. Department
of Pharmacology and Toxicology, Wright State
#838
TIME COURSE OF JP-8 JET FUEL
CONCENTRATION IN THE EPIDERMIS
AND DERMIS OF FISHER RATS AFTER
CUTANEOUS EXPOSURES. C. M. Garrett and
J. N. McDougal. Department of Pharmacology and
Toxicology, Wright State University, Dayton, OH.
#839
ESTIMATION OF HUMAN SKIN
PERMEABILITY COEFFICIENTS OF JET
FUEL COMPONENTS IN VIVO. D. Kim1,
M. E. Andersen2 and L. A. Nylander-French1.
1
of North Carolina at Chapel Hill, Chapel Hill, NC
and 2CIIT Centers for Health Research, Research
Triangle Park, NC.
#840
DERMAL MICRODIALYSIS OF
PROINFLAMMATORY NEUROCHEMICALS
AS MARKERS OF SKIN IRRITATION AFTER
EXPOSURE WITH JP-8 CHEMICALS. S.
FULZELE, R. J. Babu, E. Ahaghotu and M. Singh.
College of Pharmacy, Florida A&M University,
Tallahassee, FL.
126
#841
EVALUATION OF SKIN BARRIER CREAMS
TO JP-8 IRRITATION IN NEW ZEALAND
WHITE RABBITS (ORTYCTOLAGUS
CUNICULI). S. C. Stevens1, D. L. Pollard2, T. A.
Minnick1, A. J. Guilfoil1, R. J. Godfrey2, C. M.
Amato3 and J. J. Schlager1. 1AFRL, Wright-Patterson
AFB, OH, 2Alion, Wright-Patterson AFB, OH and
3
ORISE, Oak Ridge, TN.
#842
PARTITIONING BEHAVIOR OF SELECTIVE
AROMATIC AND ALIPHATIC JET FUEL
COMPONENTS ACROSS MEMBRANES. R.
E. Baynes, X. R. Xia, B. M. Barlow, J. L. Yeatts
and J. E. Riviere. Center for Chemical Toxicology
State University, Raleigh, NC.
#843
INERT MULTIPLE MEMBRANE-COATED
FIBERS PREDICT DERMAL ABSORPTION
OF CHEMICALS FROM MIXTURES. J. E.
Riviere, X. Xia, R. E. Baynes and N. A. MonteiroRiviere. Center for Chemical Toxicology Research
and Pharmacokinetics, North Carolina State
#844
EFFECTS OF A TOPICAL HEDGEHOG
ANTAGONIST ON NORMAL SKIN. K.
Flagella1, A. Bricarello1, T. Merriman2, K. Lewis1,
E. Choo1, H. La1, T. Patapoff1 and N. Dybdal1.
1
Safety Assessment, Genentech, Inc., South San
Francisco, CA and 2Charles River Laboratories, Inc.,
Spencerville, OH.
#845
DERMAL TOXICITY OF THE
TROPICAL CYANOBACTERIUM
CYLINDROSPERMOPSIS RACIBORSKII.
A. A. Seawright, I. Stewart, S. X. Shen and G. R.
Shaw. National Research Centre for Environmental
Toxiclogy, The University of Queensland, Brisbane,
QLD, Australia. Sponsor: M. Hughes.
#846
ANTIOXIDANT DEFENSE AND TOXIC
EFFECTS OF OCCUPATIONAL CHEMICALS
TO SKIN. A. R. Murray1, E. Kisin2, V. Castranova1,
2
, C. Kommineni2 and A. A. Shvedova1, 2.
1
Physiology and Pharmacology, West Virginia
University, Morgantown, WV and 2PPRB, NIOSH,
Morgantown, WV.
#847
EVALUATION OF DIPHOTERINE FOR
RINSING OF ALKALI BURNS AT THE
HOSPITAL. L. Mathieu1, H. Merle2, M.
Gerard2, P. Josset3 and A. H. Hall4. 1Scientific
Researches, PREVOR laboratory, Talence, France,
2
Ophthalmology, University Hospital, Fort de
France, Martinique, France, 3Anatomopathology,
Trousseau Hospital, Paris, France and 4TCMTS, Elk
Mountain, WY.
45th Annual
Meeting & ToxExpo
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
#855
EXPOSURE TO NATURALLY OCCURRING
ASBESTOS DURING OFFROAD VEHICLE
AND CAMPING/HIKING ACTIVITIES AT A
RECREATIONAL AREA IN CALIFORNIA. D.
Stralka, L. Suer and A. Den. Region 9, U.S. EPA,
San Francisco, CA. Sponsor: G. Hiatt.
#856
PERSONAL EXPOSURES TO NATURALLYOCCURRING ASBESTOS DURING SPORTS
AND PLAY ACTIVITIES IN A CALIFORNIA
COMMUNITY IN THE SIERRA FOOTHILLS.
G. F. Hiatt, A. R. Den and J. M. Johnson. Region 9,
U.S. EPA, San Francisco, CA.
POSTER SESSION: EPIDEMIOLOGY/EXPOSURE ASSESSMENT
Chairperson(s): Janice Chambers, Mississippi State University,
Mississippi State, MS and Thomas Hesterberg, International Truck and
Engine Corporation, Littleton, CO.
#848
BERYLLIUM EXPOSURE AND THE
PREVALENCE OF CHRONIC BERYLLIUM
DISEASE AND BERYLLIUM SENSITIZATION.
E. Donovan1, A. Madl1, M. Kelsh2 and D.
Paustenbach1. 1ChemRisk, Inc., San Francisco, CA
and 2Exponent, Menlo Park, CA.
#857
RETROSPECTIVE EXPOSURE ANALYSIS
OF RESIDENTIAL EXPOSURE TO
PERFLUOROOCTANOIC ACID (PFOA) FROM
1951 TO 2003. D. J. Paustenbach1, P. K. Scott2, K.
M. Unice2 and J. M. Panko2. 1ChemRisk, Inc., San
Francisco, CA and 2ChemRisk, Inc., Pittsburgh, PA.
#849
BERYLLIUM SENSITIZATION AND
CHRONIC BERYLLIUM DISEASE IN A
BERYLLIUM METAL MACHINING PLANT:
ANALYSIS OF BERYLLIUM EXPOSURE AND
IMPLICATIONS FOR AN OCCUPATIONAL
EXPOSURE LIMIT. A. Madl1, K. Unice1, J.
Brown1, M. Kolanz2 and M. Kent2. 1ChemRisk,
Inc., San Francisco, CA and 2Brush Wellman Inc.,
Cleveland, OH.
#858
NICKEL ABSORPTION FOLLOWING WATER
INGESTION IN ADULTS: A PROBABILISTIC
APPROACH TO ESTIMATION OF NICKEL
BIOAVAILABILITY. M. H. Follansbee, T. L.
Negley, W. T. Thayer, P. E. Goodrum and G. L.
Diamond. Environmental Science Center, Syracuse
Research Corporation, Syracuse, NY.
#859
SURVEY OF RECREATIONAL ACTIVITIES
ALONG KING COUNTY, WA SHORELINES
FOR USE IN SITE-SPECIFIC RISK
ASSESSMENT: EXPOSURE DISTRIBUTIONS
FOR SEDIMENT AND WATER CONTACT
ACTIVITIES AND FISH CONSUMPTION.
D. B. Mayfield1, S. Robinson1 and J. Simmonds2.
1
Parametrix, Inc., Bellevue, WA and 2Department of
Natural Resources and Parks, King County, Seattle,
WA.
#860
ESTIMATING SOURCE CONTRIBUTION
INSIDE SCHOOL BUSES. M. D. Easter1, R.
Ireson2, L. Liu3, D. Lawson4, B. Zielinska5, J.
Ondov6, C. Weaver7, M. Davey3, C. Lapin8 and T.
Hesterberg9. 1EnSIGHT, Walnut Creek, CA, 2Air
Quality Management Consulting, Greenbrae, CA,
3
University of Washington, Seattle, WA, 4National
Renewable Energy Laboratory, Golden, CO.,
5
Desert Research Institute, Reno, NV, 6University
of Maryland, Baltimore, MD, 7Engine Fuel &
Emissions Engineering, Inc., Rancho Cordova,
CA, 8Lapin & Associates, Los Angeles, CA and
9
International Truck and Engine Corp., Chicago, IL.
#861
PYRETHROIDS EXPOSURE IN THE
CANADIAN POPULATION: A CASE STUDY
IN MONTRéAL. M. C. Fortin1, M. Bouchard2, 1
and G. Carrier1. 1Environmental and Occupational
Health, Universite de Montréal, Montréal, QC,
Canada and 2Institut national de sante publique du
Quebec, Montréal, QC, Canada.
#850
ANALYSIS OF EXPOSURE TO BENZENE
IN MINERAL SPIRIT SOLVENTS DURING
PARTS WASHING AND DEGREASING
OPERATIONS. J. Greene, E. Goswami, P. Sheehan
and J. Hicks. Exponent, Oakland, CA.
#851
RECONSTRUCTION OF BENZENE
EXPOSURES DURING THE SIMULATED
USE OF A PENETRATING AND DE-RUSTING
AGENT. P. R. Williams1, J. Knutsen1 and D. J.
Paustenbach2. 1ChemRisk, Boulder, CO and
2
ChemRisk, San Francisco, CA.
#852
RECONSTRUCTION OF EXPOSURE OF
SKILLED CRAFTSMEN TO ASBESTOS AT
THE BEAUMONT, TEXAS REFINERY (19462004). P. R. Williams1 and D. J. Paustenbach2.
1
ChemRisk, Boulder, CO and 2ChemRisk, San
Francisco, CA.
#853
ASSESSMENT OF ASBESTOS EXPOSURE
AMONG AUTOMECHANICS SERVICING
AND HANDLING ASBESTOS CONTAINING
GASKETS. C. L. Blake2, G. Dotson1 and R. D.
Harbison1. 1Environmental and Occupational
Health, USF-COPH, Tampa, FL and 2Clayton Group
Services, Kennesaw, GA.
#854
CHARACTERIZATION OF CHRYSOTILE
ASBESTOS EXPOSURES FOR GARAGE
MECHANICS. J. Pierce1, F. Mowat2 and B.
L. Finley1. 1ChemRisk, San Francisco, CA and
2
Exponent, Menlo Park, CA.
127
TUESDAY
45th Annual
Meeting & ToxExpo
#862
ASSESSING EXPOSURE LEVELS
OF CHILDREN TO FLEA CONTROL
INSECTICIDES (CHLORPYRIFOS,
TETRACHLORVINPHOS, AND
PERMETHRIN) FROM THE FUR OF DOGS.
M. K. Davis, M. Russak, J. W. Tyler, J. S. Boone,
M. K. Ross and J. E. Chambers. Center for
Environmental Health Sciences, Mississippi State
University, Mississippi State, MS.
#863
DDE LEVELS BEFORE AND DURING
HUMAN PREGNANCY: A LONGITUDINAL
STUDY. S. J. Rothenberg1, 2, L. Torres Sanchez1,
M. E. Cebrián2, C. del Rio Garcia1, R. Garcia
Hernandez1 and L. Lopez Carrillo1. 1Instituto
Nacional de Salud Publica, Cuernavaca, Morelos,
Mexico and 2CINVESTAV, DF and Merida, Mexico.
#864
DETERMINATION OF PRESENT
AND FUTURE BODY BURDENS OF
POLYCHLORINATED BIPHENYLS IN
CANADIANS. N. H. Gosselin1, M. Bouchard1,
3
, N. El Majidi1, D. Shoen2 and G. Carrier1.
1
of Montréal, Montréal, QC, Canada, 2Health
Canada, Longueuil, QC, Canada and 3Institut
national de sante publique du Quebec, Montréal,
QC, Canada.
#865
COMPARATIVE STUDY ON PERSISTENT
ORGANIC POLLUTANTS CONTAMINATION
IN HUMAN MILK IN HEBEI PROVINCE,
CHINA AND TOKYO, JAPAN. F. Kayama1,
S. Sun1, 2, J. Zhao1, 2, H. Horiguchi1, H. Uno1, T.
Iida3, H. Fukatu4, M. Nakamura5 and G. Clark6.
1
Center for Community Medicine, Jichi Medical
University, Kawachi-Gun, Tochigi, Japan, 2School
of Public Health, Hebei Medical University,
Shijiazhuang, China, 3Fukuoka Institute of Health &
Environmental Sciences, Fukuoka, Japan, 4SRL Inc.,
Tachikawa, Tokyo, Japan, 5Hiyoshi Corporation,
Ohmi-Hachiman, Japan and 6Xenobiotic Detection
System International Inc., Durham, NC.
TUESDAY
#866
PAINTING AND ACUTE LEUKEMIA: AN
EVIDENCE-BASED CAUSATION ANALYSIS.
J. K. Britt1, N. C. Halmes2 and R. C. James1, 2.
1
TERRA, Inc., Tallahassee, FL and 2TERRA, Inc.,
Denver, CO.
#867
ANDROGEN LEVELS MAY NOT MEDIATE
THE ASSOCIATION BETWEEN CURRENT
ALCOHOL USE AND HOT FLASHES IN
MIDLIFE WOMEN. C. Schilling1, L. Gallicchio2,
S. Miller3, L. M. Lewis1, H. Zacur3 and J. A. Flaws1.
1
Department of Epidemiology and Preventive
Medicine, University of Maryland, Baltimore,
MD, 2Department of Epidemiology, Johns Hopkins
University, Baltimore, MD and 3Department
of Gynecology and Obstetrics, Johns Hopkins
University, Baltimore, MD.
128
#868
EXACERBATION OF VIRAL HEPATITIS
IN WORKPLACES -IN RELATION TO
CHEMICAL EXPOSURE-. T. Kawamoto, R.
Narai, T. Oyama, T. Isse, T. Kinaga, M. Ogawa,
T. Yamaguchi, T. Murakami and Y. Yashima.
Department of Environmental Health, University
Kitakyushu, Japan.
#869
EPIDEMIOLOGICAL DATA SUGGEST THAT
ARSENIC HAS A THRESHOLD FOR HUMAN
CANCERS. S. H. Lamm1, 2, 3, D. M. Byrd4, C. Penn2,
A. Engel1, R. Chen3 and M. Feinleib2. 1Consultants
in Epidemiology and Occupational Health, LLC.,
Washington, DC, 2Johns Hopkins UniversityBloomberg School of Public Health, Baltimore,
MD, 3Georgetown University Graduate School
and School of Medicine, Washington, DC and
4
Consultants in Toxicology, Risk Assessment, and
Product Safety, McLean, VA.
#870
COMPARATIVE EVALUATION OF TWO
APPROACHES FOR THE DETERMINATION
OF METHYLMERCURY AND SELENIUM
STATUS: FOOD FREQUENCY
QUESTIONNAIRE AND TOXICOKINETIC
MODELING. N. Noisel1, M. Bouchard2, 1, M.
Plante3 and G. Carrier1. 1Environmental and
Occupational Health, Universite de Montréal,
Montréal, QC, Canada, 2Institut National de Santé
Publique du Quebec, Montréal, QC, Canada and
3
Health and Safety Department, Hydro-Quebec,
Montréal, QC, Canada.
#871
DEVELOPMENT OF A NONINVASIVE
IMMUNOAFFINITY BASED ASSAY TO
PRESCREEN POPULATIONS EXPOSED TO
DIETARY AFLATOXINS. N. A. Malek, H. J.
Huebner, E. Afriyie-Gyawu, J. F. Taylor, B. Dash and
T. D. Phillips. College of Veterinary Medicine, Texas
A&M University, College Station, TX.
#872
OCCUPATIONAL EXPOSURE TO NITROUS
OXIDE, ISOFLURANE, AND SEVOFLURANE
IN OPERATING THEATRES AT ENKöPINGS
HOSPITAL SWEDEN. B. Sahlberg and H. Anundi.
Department of Occupational and Environmental
Medicine, Uppsala, Sweden.
#873
PROTECTIVE CLOTHING MATERIAL
PERMEABILITY TO CREOSOTE. D. Hooton1
and J. H. Butala2. 1Midwest Research Institute,
Kansas City, MO and 2Toxicology Consultants, Inc.,
Gibsonia, PA.
#874
IMPAIRED WOUND HEALING BY
EXPOSURE OF DIFFERENT MAINSTREAM
WHOLE SMOKE SOLUTIONS OF
COMMERCIAL CIGARETTES. S. Ejaz1, 2,
3
, I. Chekarova1, 2, 3 and C. Lim1, 2, 3. 1Department
of Pathology, Biosafety Research Institute,
Chonbuk National University, Jeonju, South Korea,
2
Department of Pathology, Chonbuk National
University, Jeonju, South Korea and 3Department
of Pathology, Chonbuk National University, Jeonju,
South Korea. Sponsor: C. Lim.
45th Annual
Meeting & ToxExpo
#875
DISTRIBUTIONAL CONTROLS ON NONLINEAR DOSE-RESPONSE RELATIONSHIPS.
T. S. Bowers and B. D. Beck. Gradient Corporation,
Cambridge, MA.
#876
USE OF INTERNET-BASED SURVEYS
TO ACCESS GLOBAL OCCUPATIONAL
EXPOSURE DATA. D. MacNair2, J. Schell1, J.
Glenn2 and D. Tollerud3. 1BBL Sciences, Houston,
TX, 2Triangle Economic Research, Durham, NC and
3
#877
#878
DNA CHIP-BASED GENE EXPRESSION
PROFILE DIFFERENCES BETWEEN
SPECIES BY ORAL ADMINISTRATION
OF TRICHLOROETHYLENE. N. Yoshioka,
Y. sano, H. Nakashima, N. Etoh, Y. Nishiwaki, T.
Takebayashi and K. Omae. Preventive Medicine and
Public Health, School of Medicine, Keio University,
Tokyo, Japan. Sponsor: M. Chiba.
INDOOR EXPOSURES AND RISK OF
ASTHMA AND ALLERGY: A SYSTEMATIC
AND CRITICAL REVIEW. M. Lovik1, 2, J. V.
Bakke3, 4, K. H. Carlsen5, 8, J. A. Jensen2, K. I.
Myhre6, 7, P. Nafstad8, 9, E. Omenaas3, 10, T. F. Wisloff6
and I. N. Norderhaug6. 1Division of Environmental
Medicine, Norwegian Institute of Public Health,
Oslo, Norway, 2Faculty of Medicine, NTNU,
Trondheim, Norway, 3University of Bergen, Bergen,
Norway, 4Norwegian Labour Inspection Authority,
Gjoevik, Norway, 5Voksentoppen BKL, National
Hospital (Rikshospitalet), Oslo, Norway, 6Norwegian
Health Services Research Centre, Oslo, Norway,
7
Clinic for Allergy and Pulmonary Diseases,
Oslo, Norway, 8University of Oslo, Oslo, Norway,
9
Norwegian Institute of Public Health, Oslo, Norway
and 10Haukeland University Hospital, Bergen,
Norway. Sponsor: E. Dybing.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
#881
A DECISION TREE INCORPORATING
VAPOR INTRUSION INTO SCREENING RISK
ASSESSMENTS OF HAZARDOUS WASTE
SITES. P. Wong-Yim, L. A. Sarmiento, M. J. Wade
and B. K. Davis. Department of Toxic Substances
Control, California Environmental Protection
Agency, Sacramento, CA.
#882
EVALUATION OF THE RD50 FOR
DETERMINING ACCEPTABLE LEVELS
OF EXPOSURE TO AIRBORNE SENSORY
IRRITANTS. Y. Kuwabara, G. V. Alexeeff, R. L.
Broadwin and A. G. Salmon. OEHHA, Oakland, CA.
#883
CRITICAL REVIEW OF TRADITIONAL
DRINKING WATER DEFAULTS FOR
CHILDREN: IMPLICATIONS FOR RISK
ASSESSMENTS. A. Arcus1, C. A. Caraway2, R. A.
Howd1 and A. M. Fan1. 1OEHHA, Cal/EPA, Oakland,
CA and 2OEHHA, Cal/EPA, Sacramento, CA.
#884
THE ANALYSIS OF MIXED DISCRETE
AND CONTINUOUS OUTCOMES USING
DESIRABILITY FUNCTIONS. T. Coffey2, C.
Gennings3 and V. C. Moser1. 1NTD/NHEERL,
U.S. EPA, Research Triangle Park, NC, 2Amylin
Pharmaceuticals, San Diego, CA and 3Biostatistics
Department, VCU, Richmond, VA.
#885
A DECISION-MAKING FRAMEWORK FOR
SENSITIZATION SAFETY ASSESSMENT OF
A NEW CHEMICAL. S. Kim1, S. S. Kim2 and D.
H. Kim1. 1ToxiSan, Fairfield, CA and 2University of
California, Berkeley, CA.
#886
DEVELOPMENTAL TOXICITY AS
AN ENDPOINT FOR HEALTH RISK
ASSESSMENT. G. L. Ball, C. J. McLellan and V. S.
Bhat. Toxicology Services, NSF International, Ann
Arbor, MI. Sponsor: M. Dourson.
#887
A RETROSPECTIVE ANALYSIS OF
DEVELOPMENTAL STUDIES UTILIZED FOR
THE RISK ASSESSMENT OF PESTICIDES.
E. Mendez and E. Reaves. Office of Pesticides
Program, U.S. EPA, Washington, DC. Sponsor: L.
Scarano.
#888
PRELIMINARY VALIDATION STUDIES
OF BCO-P. E. Deparade, W. Wang-Fan and
L. G. Ullmann. Toxicology, RCC Ltd., Itingen,
Switzerland. Sponsor: K. Sachsse.
#889
CONSIDERATIONS IN ASSESSING THE
SIGNIFICANCE OF INCREASED INCIDENCE
OF LARGE GRANULAR LYMPHOCYTE
LEUKEMIA (LGLL) IN F344 RATS FOR
HUMAN CANCER RISK ASSESSMENT. P.
J. Spencer1, J. I. Goodman2, J. K. Haseman3, T. P.
Loughran4, J. Thomas1 and J. M. Ward5. 1The Dow
Chemical Company, Midland, MI, 2Michigan State
University, East Lansing, MI, 3Consultant, formerly,
NIEHS, Raleigh, NC, 4Penn State Cancer Center,
Hershey, PA and 5Consultant, Montgomery Village,
MD.
POSTER SESSION: RISK ASSESSMENT METHODS—
REGULATORY/POLICY
Chairperson(s): Gunnar Johanson, Karolinska Institutet, Stockholm,
Sweden and Robert Howd, Cal/EPA, Oakland, CA.
#879
INCORPORATING HAZARD
IDENTIFICATION AND RISK ASSESSMENT
INTO AN OCCUPATIONAL HEALTH
AND SAFETY PROGRAM FOR ANIMAL
RESEARCH. L. M. Milchak and D. C. Rothbauer.
Environmental Health and Safety, University of
#880
PROCESSES TO MINIMIZE GENOTOXIC
IMPURITIES IN PRODUCTION OF A NEW
DRUG SUBSTANCE. J. P. Bercu, C. M. Callis, J.
M. Fiori and R. D. Meyerhoff. Toxicology and Drug
Disposition, Lilly Research Laboratories, a Division
of Eli Lilly and Company, Greenfield, IN.
129
TUESDAY
45th Annual
Meeting & ToxExpo
#890
A CONCEPTUAL FRAMEWORK FOR
EVALUATING THE ADEQUACY OF
THE DEFAULT HUMAN KINETICS
UNCERTAINTY FACTOR FOR PROTECTING
CHILDREN. A. Maier, E. Hack, J. Zhao and L.
Haber. Toxicology Excellence for Risk Assessment,
Cincinnati, OH.
#891
THE DEVELOPMENT OF A TIMEDEPENDENT MODEL TO ANALYZE
NEUROBEHAVIORAL TOXICITY DATA
FOR RISK ASSESSMENT. A. S. Howard1, M.
R. Wessel3, J. S. Gift1, Y. Zhu3 and V. C. Moser2.
1
NCEA, Environmental Protection Agency, Research
Triangle Park, NC, 2NHEERL, Environmental
Protection Agency, Research Triangle Park, NC and
3
Epidemiology and Biostatistics, University of South
Florida, Tampa, FL.
#892
#893
#894
TUESDAY
#898
FUNCTIONAL INTERPRETATION OF DOSE
AND TIME-DEPENDENT MICROARRAY
DATA: QUANTITATIVE INTEGRATION
OF GO ONTOLOGY ANALYSIS FOR
TOXICOLOGY AND RISK ASSESSMENT. X.
Yu1, W. Griffith1, K. Hanspers2, J. Robinson1 and E.
M. Faustman1. 1Environmental Health, IRARC, UW,
Seattle, WA and 2GenMAPP, Gladstone Institute of
Cardiovascular Disease/UCSF, SF, CA.
#899
HAZARD, EXPOSURE AND DOSE-RESPONSE
ASSESSMENT UNDER CALIFORNIA’S
PROPOSITION 65: 2006 UPDATE. L. Zeise, G.
V. Alexeeff, J. Beaumont, M. Campbell, J. Donald,
A. Dunn, J. Faust, M. Golub, S. M. Hoover, P. Iyer,
F. Kauffman, G. Krowech, L. Li, J. Morgan, M. S.
Sandy, C. D. Sherman and R. S. Tomar. OEHHA,
CalEPA, Oakland, CA.
#900
PARTICULATE MATTER CONCENTRATIONRESPONSE VERSUS DOSE-RESPONSE. J. S.
Brown and L. D. White. NCEA, U.S. EPA, Research
Triangle Park, NC.
#901
AN APPROACH FOR ESTIMATING
POPULATION-SPECIFIC INTERINDIVIDUAL VARIABILITY FACTOR.
K. Krishnan and A. Nong. Occupational and
Environmental Health, Universite de Montréal,
Montréal, QC, Canada.
BENCHMARK DOSE EVALUATION FOR
HUMAN IRRITATION. G. V. Alexeeff, K. K. Deng,
R. Broadwin and A. G. Salmon. OEHHA, Cal/EPA,
Oakland, CA.
#902
IMPLEMENTATION OF A NUMERICAL
SOLUTION TO THE NON-HOMOGENEOUS
TWO-STAGE MVK MODEL OF CANCER. C.
van Landingham1, K. Crump1 and R. Subramaniam2.
1
ENVIRON International Corp., Ruston, LA and
2
ORD, NCEA, U.S. EPA, Washington, DC. Sponsor:
P. Gentry.
VALIDATION OF MEASURES TO PREVENT
CROSS CONTAMINATION DURING DOSE
PREPARATION FOR TOXICITY STUDIES.
C. Wood and M. Wrightson. Covance Laboratories
Ltd., Harrogate, United Kingdom. Sponsor: D.
Everett.
#903
THE IMPROVEMENT OF CANINE
ACCOMMODATION IN A REGULATORY
TOXICOLOGY ENVIRONMENT. S. Blakey.
Covance Laboratories Ltd., Harrogate, United
Kingdom. Sponsor: D. Everett.
#904
DATA WAIVING UNDER EU DIRECTIVE 98/8/
EC (BIOCIDAL PRODUCTS DIRECTIVE):
A PRACTICAL EXAMPLE SPARING
APPROXIMATELY 2000 ANIMALS IN
REGISTRATION OF A RODENTICIDE. S.
Warren. Food & Chemicals Practice, Exponent
International, Harrogate, United Kingdom.
#905
THE CREATION OF CONSOLIDATED FDA
DATABASES AND THE DEVELOPMENT
OF REAL-TIME DATA ENTRY TO
SUPPORT STRUCTURE ACTIVITY
RELATIONSHIP APPROACHES IN HAZARD
IDENTIFICATION AND RISK ASSESSMENT.
K. B. Arvidson1, R. Benz2, E. J. Matthews2, J.
Mayer1, E. Lee1, M. L. Twaroski1 and C. Yang3.
1
CFSAN/OFAS, USFDA, College Park, MD,
2
CDER/OPS/ICSAS, USFDA, Silver Spring, MD
and 3Leadscope, Inc., Columbus, OH.
IMMUNOLOGICAL ENDPOINTS AND THEIR
ROLE IN THE DEVELOPMENT OF MINIMAL
RISK LEVELS (MRLS). H. Abadin1, S. Chou1
and F. Llados2. 1Agency for Toxic Substances
and Disease Registry, Atlanta, GA and 2Syracuse
Research Corp, Syracuse, NY. Sponsor: B. Fowler.
#895
ARE CHRONIC RFDS REALLY CHRONIC?
H. Goeden and P. Shubat. Environmental Health
Division, Minnesota Department of Health, St. Paul,
MN.
#896
USING WITHIN-ANIMAL VARIATION
AS AN INDICATION OF THE MINIMAL
CRITICAL EFFECT SIZE APPLICABLE IN
THE BENCHMARK DOSE APPROACH. S.
Dekkers1, J. Telman3, M. Rennen1, M. Appel2 and
C. de Heer1. 1Food and Chemical Risk Analysis,
TNO, Zeist, Netherlands, 2Toxicology and Applied
Pharmacology, TNO, Zeist, Netherlands and
3
Imaging Systems, TNO, Delft, Netherlands.
Sponsor: V. Feron.
#897
RISK ASSESSMENT FOR
NANOTECHNOLOGY AND
NANOMATERIALS: AN ADAPTIVE
APPROACH FOR HEALTH AND SAFETY
DECISION-MAKING. B. E. Barry and J. Shatkin.
The Cadmus Group, Watertown, MA.
130
45th Annual
Meeting & ToxExpo
#906
#907
#908
#909
REFERENCE SUBSTANCES FOR THE
VALIDATION OF IN VITRO OCULAR
TOXICITY TEST METHODS FOR THE
EVALUATION OF OCULAR CORROSIVES
AND SEVERE IRRITANTS. D. Allen1, 2, B.
Blackard1, 2, N. Choksi1, 2, J. Truax1, 2, R. Tice2 and
W. Stokes2. 1Integrated Laboratory Systems, Inc.,
Research Triangle Park, NC and 2NICEATM,
ESTIMATED LIKELIHOOD FOR UNDERAND OVER-CLASSIFICATION FOR A
SEQUENTIAL DRAIZE RABBIT EYE TEST. N.
Y. Choksi1, J. K. Haseman2, D. G. Allen1, R. R. Tice3
and W. S. Stokes3. 1Integrated Laboratory Systems,
Inc., Research Triangle Park, NC, 2Consultant,
Research Triangle Park, NC and 3NICEATM,
NIEHS/NIH/DHHS, Research Triangle Park, NC.
COMPARATIVE PERFORMANCE OF
FOUR IN VITRO TEST METHODS FOR
THE CLASSIFICATION OF OCULAR
CORROSIVES AND SEVERE IRRITANTS. W.
S. Stokes1, N. Y. Choksi2, D. G. Allen2, J. F. Truax2
and R. R. Tice1. 1NICEATM, NIEHS/NIH/DHHS,
Research Triangle Park, NC and 2Integrated
Laboratory Systems, Inc., Research Triangle park,
NC.
EVALUATION OF THE RELATIONSHIP
BETWEEN IN VIVO RABBIT EYE TEST
SCORES AND THEIR REVERSIBILITY. R. R.
Tice1, D. G. Allen2, N. Y. Choksi2, J. F. Truax2 and
W. S. Stokes1. 1NICEATM, NIEHS/NIH/DHHS,
Research Triangle Park, NC and 2Integrated
Laboratory Systems, Inc., Research Triangle Park,
NC.
#910
CONSIDERING THE POTENTIAL
CUMULATIVE IMPACTS OF POLLUTANTS
IN DIVERSE GEOGRAPHIC AREAS OF
CALIFORNIA. J. B. Faust, M. S. Sandy, L. Zeise
and G. V. Alexeeff. Office of Environmental Health
Hazard Assessment, California Environmental
Protection Agency, Oakland, CA.
#911
METHODS OF MANUFACTURE THAT
REMOVE CONTAMINANTS FROM
FISH OILS: INFORMATION COMPILED
THROUGH THE GRAS (GENERALLY
RECOGNIZED AS SAFE) NOTIFICATION
PROGRAM. A. Edwards, E. Garcia, C.
Hendrickson and R. Chanderbahn. Division
of Biotechnology and GRAS Notice Review
(DBGNR), Office of Food Additive Safety (OFAS),
Center for Food Safety and Applied Nutrition, Food
and Drug Administration (U.S. FDA), College Park,
MD.
#912
A NOVEL APPROACH FOR DEFINING
SCREENING LEVELS FOR INDOOR AIR
CONTAMINANTS (IACS). E. Hodge, G.
Balagopal, A. Chiu and D. Manca. Standards
Development Branch, Ontario Ministry of the
Environment, Toronto, ON, Canada.
#914
STRUCTURE-ACTIVITY ANALYSIS OF
CHEMICAL HEALTH GUIDANCE VALUES. E.
Demchuk1, B. C. Albin1, M. Fay1, R. M. Garrett2 and
H. Hansen1. 1Computational Toxicology Laboratory,
CDC/ATSDR, Atlanta, GA and 2Defense
Intelligence Agency, Washington, DC. Sponsor: B.
Fowler.
#915
PREDICTION OF SKIN ABSORPTION OF
CHEMICALS USING STRUCTURE ACTIVITY
RELATIONSHIP APPROACH. S. Basak2, D.
Mills2, S. Chou1 and M. Mumtaz1. 1CDC/ATSDR,
Atlanta, GA and 2University of MN Natural
Resources, Duluth, MN.
#916
RISK RANKING ALGORITHMS FOR
SOLVENT SUBSTITUTION IN THE
WORKPLACE. M. Debia, D. Begin, K. Krishnan
and M. Gerin. Environmental and Occupational
Health, Universite de Montréal, Montréal, QC,
Canada.
#917
SCIENTIFIC RATIONALE FOR DERIVING
DATABASE UNCERTAINTY FACTORS
FOR SAFE DOSE ESTIMATES THAT ARE
PROTECTIVE OF CHILDREN. B. Gadagbui, M.
L. Dourson and A. Maier. Toxicology Excellence for
Risk Assessment (TERA), Cincinnati, OH.
#918
KEY STEPS NEEDED FOR EVALUATING
SENSITIVE TOXICOLOGICAL EFFECTS
FOR HAZARD IDENTIFICATION. H.
Choudhury1, C. Moudgal2, J. Colman3 and M. Odin3.
1
ORD/NCEA, U.S. EPA, Cincinnati, OH, 2ORD,
U.S. EPA, Cincinnati, OH and 3Syracuse Research
Corporation, SRC, Syracuse, NY.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: DEVELOPMENTAL TOXICITY TESTING IN
MAMMALIAN SYSTEMS
Chairperson(s): Moussa Diawara, Colorado State University - Pueblo,
Pueblo, CO and Ali Faqi, MPI Research, Mattawan, MI.
#919
THE IMPORTANCE OF SUPPLIER
QUALIFICATION FOR VENDORS OF
MATERIALS USED IN IN VITRO ASSAYS. A.
K. Ulrey, R. D. Curren and J. W. Harbell. Institute
for In Vitro Sciences, Inc., Gaithersburg, MD.
#913
131
DI-(2-ETHYLHEXYL)-PHTHALATE
ALTERS EXPRESSION OF FATTY ACID
HOMEOSTASIS REGULATING PROTEINS
IN THE DEVELOPING RAT PLACENTA. Y.
Xu, T. J. Cook and G. T. Knipp. Department of
Pharmaceutics, Rutgers, The State University of
New Jersey, Piscataway, NJ.
TUESDAY
45th Annual
Meeting & ToxExpo
#920
NEAR INFRARED LIGHT THERAPY
ATTENUATES DIOXIN-INDUCED EMBRYO
MORTALITY. R. L. Yeager1, J. Lim1, D. S.
Millsap1, R. A. Sanders2, J. B. Watkins2, H. T.
Whelan4, J. T. Eells3 and D. S. Henshel1. 1School
of Public and Environmental Affairs, Indiana
University, Bloomington, IN, 2Medical Sciences,
Indiana University, Bloomington, IN, 3Health
Sciences, University of Wisconsin-Milwaukee,
Milwaukee, WI and 4Neurology, Medical College of
Wisconsin, Milwaukee, WI.
#921
5α-DIHYDROTESTOSTERONE (DHT) HAS
EFFECTS ON VENTRAL PROSTATIC BUD
FORMATION IN MICE INDEPENDENT OF
THE CLASSIC ANDROGEN RECEPTOR. S. H.
Allgeier1, T. Lin2 and R. E. Peterson2, 1. 1Molecular
and Environmental Toxicology Center, University of
Wisconsin, Madison, WI and 2School of Pharmacy,
University of Wisconsin, Madison, WI.
#922
DIFFERENTIATION OF FEMALE
UROGENITAL SINUS (UGS) TRANSPLANTS
IN NUDE MICE: AN ALTERNATIVE
MODEL TO INVESTIGATE VENTRAL
PROSTATE (VP) AGENESIS CAUSED BY 2,
3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN
(TCDD). T. Lin and R. E. Peterson. School of
Pharmacy, University of Wisconsin, Madison, WI.
#923
MODULATION OF RETINOIC ACID
SIGNALING MAY CONTRIBUTE TO
IMPAIRMENT OF VENTRAL PROSTATIC
BUD FORMATION BY TCDD IN THE
UROGENITAL SINUS OF MALE FETAL
MICE. C. Vezina1, H. Lee2, M. C. Goldberg1, K. H.
Kim2 and R. E. Peterson1. 1School of Pharmacy, UWMadison, Madison, WI and 2School of Molecular
Biosciences, Washington State University, Pullman,
WA.
TUESDAY
#924
INTERFERENCE WITH BMP4 SIGNALING
BY IN UTERO TCDD EXPOSURE MAY
CONTRIBUTE TO INHIBITION OF
PROSTATIC BUD FORMATION FROM THE
VENTRAL UROGENITAL SINUS OF MALE
FETAL MICE. W. A. Fritz, C. Vezina and R. E.
Peterson. School of Pharmacy, UW-Madison,
Madison, WI.
#925
EFFECT OF FLUTAMIDE AND ICI 182.780 ON
THE CELL-CELL ADHESION ASSOCIATE
PROTEINS IN THE MOUSE SEMINIFEROUS
TUBULES. R. Anahara1, Y. Toyama2, M. Maekawa2,
M. Yoshida1, M. Kai3, F. Ishino3, K. Toshimori2 and
C. Mori1, 4. 1Bioenvironmental Medicine, Chiba
University, Chiba, Japan, 2Department of Anatomy
and Developmental Biology, Chiba University,
Chiba, Japan, 3Medical Research Institute, Tokyo
Medical and Dental University, Tokyo, Japan and
4
Ctr Environ Health Sciences for Future Generations
(NPO), Chiba, Japan.
132
#926
IDENTIFICATION OF REGION-SPECIFIC
GENE EXPRESSION CHANGES AND
SIGNALLING PATHWAYS AFFECTED BY
DIBUTYL PHTHALATE IN FOETAL RAT
TESTES. S. Plummer1, R. Sharpe2 and C. Elcombe1.
1
CXR Biosciences Ltd., Dundee, United Kingdom
and 2MRC Human Reproductive Sciences Unit,
Edinburgh, United Kingdom.
#927
DISRUPTION OF NORMAL EMBRYONIC
ANGIOGENESIS BY DIRECT EXPOSURE OF
MAINSTREAM WHOLE SMOKE SOLUTIONS
OF COMMERCIAL CIGARETTES. C. Lim1, 2,
3
, S. Ejaz1, 2, 3 and I. Chekarova1, 2, 3. 1Department of
Pathology, Chonbuk National University, Jeonju,
South Korea, 2Department of Pathology, Chonbuk
National University, Jeonju, South Korea and
3
Department of Pathology, Chonbuk National
University, Jeonju, South Korea. Sponsor: C. Lim.
#928
LOW DOSE INHALATION OF CIGARETTE
SMOKE SHORTENS DURATION OF
GESTATION AND ALTERS HORMONE
LEVELS IMPORTANT FOR GESTATION AND
PARTURITION IN AN ANIMAL MODEL. S. P.
Ng, B. G. Steinetz and J. T. Zelikoff. Environmental
Medicine, New York University School of Medicine,
Tuxedo, NY.
#929
REPRODUCTIVE AND DEVELOPMENTAL
TOXICITY OF POLYCYCLIC AROMATIC
HYDROCARBONS (PAHS). J. C. Benedict.
National Center for Environmental Assessment,
Office of Research and Development, U.S. EPA,
Washington, DC.
#930
EFFECTS OF MATERNAL DIETS ON THE
DEVELOPMENT OF THE OFFSPRING AND
ITS VULNERABILITY FOR CHEMICALLY
INDUCED NEUROTOXICITY. A. Wolterbeek1,
S. Eussen1, R. Jansink1, L. vd Horst1, M. Otto1, I.
Waalkens1, A. Dijkstra1, F. Salmon2, H. Wortelboer2,
W. Pasman2, H. Hendriks2, I. Bobeldijk3, J. Groten2
and D. de Groot1. 1Toxicology and Applied
Pharmacology, TNO Quality of Life, Zeist,
Netherlands, 2Physiological Sciences, TNO Quality
of Life, Zeist, Netherlands and 3Analytical Sciences,
TNO Quality of Life, Zeist, Netherlands. Sponsor: V.
Feron.
#931
COPLANAR HEXABROMOBIPHENYL
NEONATAL LETHALITY IN HIGH-AFFINITY
AHR MICE IS CAUSED PRINCIPALLY BY
EXPOSURE IN UTERO RATHER THAN VIA
MOTHER’S MILK. K. A. Miller1, C. P. Curran1,
T. P. Dalton1, C. V. Vorhees2, M. L. Miller1, H. G.
Shertzer1 and D. W. Nebert1. 1Environmental Health,
University of Cincinnati, Cincinnati, OH and
2
Neurology, Cincinnati Children’s Hospital Research
Foundation, Cincinnati, OH.
#932
GENE EXPRESSION PROFILING IN THE
LUNG AND LIVER OF PFOA EXPOSED
MOUSE FETUSES. M. Rosen, J. R. Thibodeaux,
C. R. Wood, R. D. Zehr, J. E. Schmid and C. Lau.
ORD/NHEERL/RTD, U.S. EPA, Research Triangle
Park, NC,
45th Annual
Meeting & ToxExpo
#933
TOXICITY OF ALPHA-ISO-METHYLIONONE
IN RATS. V. T. Politano1, E. M. Lewis2, A. M.
Hoberman2, M. S. Christian3, R. M. Diener3 and A.
Api1. 1Research Institute for Fragrance Materials,
Inc., Woodcliff Lake, NJ, 2CRL Argus Research,
Horsham, PA and 3Argus International, Inc.,
Horsham, PA.
#941
INTRACELLULAR GLUTATHIONE LEVELS
INCREASE PRIOR TO DIFFERENTIATION
IN HL60 CELLS. S. M. Krance and N. Ballatori.
Environmental Medicine, University of Rochester
School of Medicine, Rochester, NY.
#942
CJC-1295, A LONG-ACTING GROWTH
HORMONE RELEASING FACTOR
ANALOGUE, IS NOT TERATOGENIC IN
RATS. V. Iordanova1, S. Wen1, E. Lewis2, S. Morseth3
and J. Castaigne1. 1ConjuChem, Inc., Montréal, QC,
Canada, 2Charles River Laboratories Preclinical
Services-Pennsylvania, Horsham, PA and 3Morseth
Consulting, LLC, Jefferson, MD.
#934
ASSESSMENT OF PRENATAL
DEVELOPMENT IN PBDE EXPOSED RATS
SUFFICIENT OR MARGINAL IN VITAMIN
A. R. Ellis-Hutchings, G. Cherr and C. Keen.
University of California-Davis, Davis, CA.
#935
A PRE- AND POSTNATAL STUDY OF
BICIFADINE HCL IN RATS. M. J. Beck1, J. P.
Tizzano2, P. A. Krieter2, S. Ho1, D. W. Sved1 and
J. Buelke-Sam3. 1WIL Research Laboratories,
LLC, Ashland, OH, 2DOV Pharmaceutical,
Inc., Hackensack, NJ and 3Toxicology Services,
Greenfield, IN.
#943
A DIETARY TERATOLOGY STUDY OF
A DRUG EXCIPIENT, AVICEL RCN-15®,
IN SPRAGUE-DAWLEY FEMALE RATS. J.
McCarty1, M. Weiner1, C. Freeman2 and D. Nuber1.
1
Toxicology, FMC Corporation, Princeton, NJ
and 2Toxicology, Formerly of FMC Corporation,
Princeton, NJ.
#936
A STUDY OF THE EFFECTS OF DAG
(DIACYLGLYCEROL) ON EMBRYO/FETAL
DEVELOPMENT IN RATS. J. F. Knapp1, M. D.
Nemec1, D. G. Stump1, B. J. Varsho1, O. Morita2,
Y. Tamaki2 and H. Suzuki2. 1DART, WIL Research
Laboratories, LLC, Ashland, OH and 2Safety and
Environmental Research, Kao Corporation, Haga
Tochigi, Japan.
#944
AN EXAMINATION OF CAGING
PROTOCOLS USED IN MOUSE
DEVELOPMENTAL TOXICITY RESEARCH.
S. S. Dimond1, 2. 1Environmental Health and
Safety, General Electric Plastics, Pittsfield, MA
and 2Environmental Health and Toxicology, State
University of New York at Albany, Albany, NY.
#945
#937
EFFECTS ON BIRTH WEIGHT AND ADULT
HEALTH IN RATS PRENATALLY EXPOSED
TO TOXICANTS OR UNDERNUTRITION. B.
E. Grey, B. D. Barbee, J. Norwood, K. Das, C. Lau
and J. M. Rogers. Reproductive Toxicology, ORD,
IN UTERO EXPOSURE TO BENZENE ALTERS
EMBYRONIC PIM-1 SIGNALLING IN CD-1
MICE. J. Wan1 and L. M. Winn1, 2. 1Pharmacology
and Toxicology, Queen’s University, Kingston, ON,
Canada and 2School of Environmental Studies,
Queen’s University, Kingston, ON, Canada.
#946
#938
TOXICITY OF ALPHA-METHYL-3, 4METHYLENE-DIOXYHYDROCINNAMIC
ALDEHYDE IN RATS. C. Letizia1, A. Api1, E.
M. Lewis2, A. M. Hoberman2, M. M. Christian3 and
R. M. Diener3. 1Research Institute for Fragrance
Materials, Inc., Woodcliff Lake, NJ, 2Charles River
Laboratories Preclinical Services, Horsham, PA and
3
Argus International, Inc., Horsham, PA.
EVALUATION OF THE TOXICITY AND
TERATOGENICITY OF BENZENE AMINOAND NITRODERIVATIVES FOR THEIR
REGULATION IN OCCUPATIONAL AIR. K.
K. Kabirov and A. V. Lyubimov. Pharmacology,
Toxicology Research Laboratory, University of
Illinois at Chicago, Chicago, IL.
#947
DIGITAL PHOTOGRAPHY OF NORMAL AND
MALFORMED VISCERAL SECTIONS OF
DAY-20 FETAL RAT: AN EFFICIENT TOOL
FOR TRAINING FUTURE DEVELOPMENTAL
TOXICOLOGISTS. A. S. Faqi, S. Magness
and K. Collison. Developmental & Reproductive
Toxicology, MPI Research, Mattawan, MI.
#939
8-MOP AND HEAVY METALS DISRUPT
HAMSTER EMBRYO DEVELOPMENT. M.
M. Diawara1 and D. Unis1. 1Biology, Colorado
State University-Pueblo, Pueblo, CO and 2Biology,
Colorado State University-Pueblo, Pueblo, CO.
#940
A COMBINED REPEATED DOSE ORAL
TOXICITY AND REPRODUCTIVE/
DEVELOPMENTAL TOXICITY-SCREENING
STUDY OF 2-MERCAPTOETHANOL IN
RATS. J. REGNIER1, W. Gaoua-Chappelle1, 2, O.
Foulon2, V. Santa Cruz3 and R. Jaeckh4. 1ARKEMA,
Paris-la-Defense, France, 2Centre International
de Toxicologie (CIT), Evreux, France, 3ChevronPhillips Chemicals Co., The Woodlands, TX and
4
BASF AG, Ludwigshafen, Germany.
133
TUESDAY
45th Annual
Meeting & ToxExpo
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
#954
INCREASED CELL PROLIFERATION AND
REDUCED P27 EXPRESSION BY TRANS,
TRANS-2, 4-DECADIENAL VIA OXIDATIVE
STRESS IN HUMAN BRONCHIAL
EPITHELIAL CELLS. P. Lin1, 2, W. Lo1, Y.
Chang1 and L. W. Chang2. 1Institute of Medical
and Molecular Toxicology, Chung Shan Medical
University, Taichung, Taiwan and 2Division of
Environmental Health and Occupational Medicine,
National Health Research Institutes, Kaoshiung,
Taiwan.
#955
ACRYLONITRILE INDUCES OXIDATIVE
DNA DAMAGE IN RAT GLIAL CELLS. X. Pu,
L. M. Kamendulis and J. E. Klaunig. Pharmacology
and Toxicology, Indiana University, Indianapolis, IN.
#956
REGULATION OF GAP JUNCTIONS BY TPA
IN COLON CANCER CELLS. V. B. Nareddy
and A. Nguyen. Diagnostic Medicine/Pathobiology,
Kansas State University, Manhattan, KS.
#957
ROLE OF OXIDATIVE DNA DAMAGE IN
HUMAN ESOPHAGEAL CARCINOGENESIS.
Z. wang1, Y. Tang1, H. Luo1, G. Sun2, Y. Xie2, S.
Wang2, X. Hu3, L. Tang1 and J. Wang1. 1Department
of Environmental Toxicology, Texas Tech University,
The Institute of Environmental and Human Health
(TIEHH), Lubbock, TX, 2Southeast University,
Nanjing, China and 3CDC Huaian Branch, Huaian,
Jiangsu, China.
#958
ANALYSIS OF PAKTSER473, NFκB
PP65SER276 AND PIκB-αSER32/36 IN NNITROSOMETHYLBENZYLAMINE
(NMBA)-INDUCED RAT
ESOPHAGEAL TUMORIGENESIS BY
IMMUNOHISTOCHEMISTRY. T. Chen, R. G.
Nines and G. D. Stoner. Internal Medicine, The Ohio
State University, Columbus, OH.
#959
REGULATION OF GAP JUNCTIONS BY
TCDD IN BREAST CANCER CELLS. G.
Gakhar, D. Lawn and A. Ngyuen. Diagnostic
Medicine/Pathobiology, KSU, Manhattan, KS.
#960
MODULATION OF TRANSCRIPTION
FACTOR BINDING TO CONNEXIN 32
PROMOTER BY HEXACHLOROBENZENE
IN FEMALE RATS. I. Plante, D. Cyr and M.
Charbonneau. INRS-Institut Armand-Frappier,
Universite du Quebec, Montréal, QC, Canada.
#961
THE ROLE OF PHOSPHOLIPASES IN
THE INHIBITION OF GAP JUNCTION
COMMUNICATION AND THE ACTIVATION
OF MAPK BY SPECIFIC ISOMERS OF
METHYLATED ANTHRACENES. PART 1. L.
Blaha, J. E. Trosko and B. L. Upham. Pediatrics &
Human Development, and National Food Safety &
Lansing, MI.
POSTER SESSION: CARCINOGENESIS MECHANISMS
Chairperson(s): Stephen Safe, Texas A&M University, College Station, TX
and Lisa Kamenduus, Indiana University, Indianapolis, IN.
#948
#949
#950
#951
TUESDAY
#952
#953
COMPLEX STRUCTURE-DEPENDENT
ACTIVATION OF ESTROGEN
RECEPTOR(ERα)/SP1 IN BREAST CANCER
CELLS. F. Wu1 and S. Safe2, 1. 1Biochemistry and
Biophysics, Texas A&M University, College Station,
TX and 2Veterinary Physiology & Pharmacology,
Texas A&M University, College Station, TX.
4-HYDROXYCATECHOL ESTRADIOL IS
CARCINOGENIC IN HUMAN BREAST
EPITHELIAL CELLS. Q. Felty1, V. Okoh1,
S. Narayan2 and D. Roy1. 1Department of
Environmental & Occupational Health, Florida
International University, Miami, FL and
2
Department of Anatomy and Cell Biology,
University of Florida, Gainesville, FL.
PROMOTION OF TUMORGENICITY BY
β-HEXACHLOROCYCLOHEXANE IN
MCF10AT1 CELLS AND MMTV-NEU MICE.
P. S. Wong and F. Matsumura. Center for Health and
the Environment, University of California, Davis,
Davis, CA.
STRUCTURE-DEPENDENT ANDROGEN
RECEPTOR (AR) AGONIST/ANTAGONIST
ACTIVITIES AND AR DOWNREGULATION
BY RING SUBSTITUTED 1, 1-BIS(3’INDOLYL)METHANES (DIMS). L. Kotha and
S. Safe. Veterinary Physiology and Pharmacology,
Texas A&M University, College Station, TX.
2-D GEL COMPARISON OF THE ACI RAT
MAMMARY GLAND AND MAMMARY
TUMORS INDUCED BY 17B-ESTRADIOL. X.
Lin1, M. Gallo2, K. Reuhl1, B. Buckley1, I. Yang1 and
P. Thomas1. 1Rutgers, The State University of NJ,
Piscataway, NJ and 2UMDNJ, Piscataway, NJ.
PERSISTENT GENE EXPRESSION CHANGES
INDUCED BY DIETHYLSTILBESTROL IN
THE NEONATAL MOUSE UTERUS: ROLE
OF EPIGENETICS IN CARCINOGENESIS.
F. Lim, R. A. Currie, K. Antrobus, D. J. Moore, H.
Tinwell, J. Odum, J. Harris, S. Moreland, J. Wright,
I. Kimber, J. Ashby, G. Orphanides and J. G. moggs.
CTL, Syngenta, Macclesfield, United Kingdom.
134
45th Annual
Meeting & ToxExpo
#962
DYSFUNCTION OF P27KIP1 IS ASSOCIATED
WITH INCREASED MOUSE URINARY
BLADDER TUMOR SIZE. K. Ogawa, A.
Hikosaka, S. Sugiura, M. Asamoto, S. Suzuki and T.
Shirai. Experimental Pathology and Tumor Biology,
Nagoya City University Graduate School of Medical
Sciences, Nagoya, Japan.
#963
OCHRATOXIN A BLOCKS METAPHASEANAPHASE TRANSITION, RESULTING IN
APOPTOSIS AND ABERRANT EXIT FROM
MITOSIS. A. Mally, E. Rached and W. Dekant.
Department of Toxicology, University of Wüerzburg,
Wüerzburg, Germany.
#964
CONDITIONAL DOWN-REGULATION
OF ARYL HYDROCARBON RECEPTOR
NUCLEAR TRANSLOCATOR INHIBITS
TUMOR GROWTH AND ANGIOGENESIS IN
A SUBCUTANEOUS MOUSE XENOGRAFTS
MODEL. S. T. Shi, D. Yoon, K. Hodge-Bell and O.
Hankinson. University of California - Los Angeles,
Los Angeles, CA.
#965
PPARβ INDUCES DIFFERENTIATION
AND INHIBITS CELL PROLIFERATION IN
HUMAN AND MURINE KERATINOCYTES.
A. D. Burdick1, M. T. Bility1, D. Kim1, A. N. Billin2,
T. M. Willson2 and J. M. Peters1. 1Department of
Veterinary Science, Center for Molecular Toxicology
and Carcinogenesis, The Pennsylvania State
University, University Park, PA and 2Discovery
Research, GlaxoSmithKline, Research Triangle
Park, NC.
#966
#967
#968
MIXED LINEAGE LEUKEMIA GENE
REARRANGEMENTS IN HUMAN
HEMATOPOIETIC STEM CELLS EXPOSED
TO ETOPOSIDE AND CHLORPYRIFOS.
E. P. Gallagher1, J. Shao1, C. Moneypenny2, M.
Eckert1, P. Stapleton1, T. Bammler1, R. Beyer1 and
F. Farin1. 1Environmental and Occupational Health
Sciences, University of Washington, Seattle, WA
and 2Hematology and Oncology, St. Jude Children’s
Research Hospital, Memphis, TN.
GENETIC ALTERATIONS IN CANCER:
GENE MUTATIONS IN LUNG AND LIVER
TUMORS OF MICE AND HUMANS EXPOSED
TO ENVIRONMENTAL AGENTS. M. Jackson1,
I. Lea1, A. Rashid2, S. Peddada3 and J. Dunnick3.
1
Health and Information Sciences Division, ILS,
Inc., Research Triangle Park, NC, 2Software
Development, AGTI, Inc., Raleigh, NC and
3
Environmental Toxicology Program, NIEHS,
A NOVEL POLYMORPHIC RAT NACETYLTRANSFERASE ALLELE (NAT3*2)
WITH REDUCED CATALYTIC ACTIVITY IN
VITRO. J. M. Walraven, D. F. Barker, M. A. Doll and
D. W. Hein. Pharmacology & Toxicology and Brown
Cancer Center, University of Louisville, Louisville,
KY.
135
#969
APOPTOSIS AND SENESCENCE IN
CARCINOGENIC MODELING USING MDM2P53 KNOCKOUT MICE. A. O. Chiu1, N. H.
Chiu2, D. V. Singh1, J. Beaubier3 and L. Donehower4.
1
NCEA DC, U.S. EPA, Washington DC, DC, 2OST
OW, U.S. EPA, Washington DC, DC, 3OPPTS, U.S.
EPA, Washington DC, DC and 4Medical Center,
Baylor University, Houston, TX.
#970
GENETIC SUSCEPTIBILITY OF THE
TRP53 HAPLOINSUFFICIENT MOUSE TO
RADIATION INDUCED LYMPHOMA. J. E.
French and V. Parron. NIEHS, NIH, Research
Triangle Park, NC.
#971
REFINEMENT OF PCR-BASED DGGE FOR
ANALYSIS OF MUTATIONS IN THE P53
TUMOR SUPPRESSOR GENE FOLLOWING
IN UTERO EXPOSURE TO NRTIS. S. M. Torres1,
2
, D. L. Cook2, D. M. Walker2, O. A. Olivero3,
M. C. Poirier3 and V. E. Walker2. 1Toxicology,
University of New Mexico, Albuquerque, NM,
2
LRRI, Albuquerque, NM and 3Carcinogen-DNA
Interactions Section, National Cancer Institute,
Bethesda, MD.
#972
IN VIVO MUTAGENICITY AND INITIATION
ACTIVITY FOLLOWING OVEREXPRESSION
OF OGG1 AND INCREASE OF 8HYDROXYGUANINE FORMATION IN THE
KIDNEY OF RATS GIVEN POTASSIUM
BROMATE. T. Umemura1, K. Keita1, Y. Kuroiwa1,
Y. Ishii3, K. Okano3, T. Nohmi2, A. Nishikawa1 and
M. Hirose1. 1Division of Pathol., National. Institute
Hlth. Sciences., Tokyo, Japan, 2Division of Genetics,
Mutagenesis, National. Institute Hlth. Sciences.,
Tokyo, Japan and 3Department.of Anal. Chem.,
Faculty of Pharma. Sciences., Hoshi University,
Tokyo, Japan.
#973
IDENTIFICATION OF COVALENT
MODIFICATIONS IN P450 2E1 BY 1, 2EPOXY-3-BUTENE. G. Boysen1, C. O. Scarlett2,
B. Temple3, N. I. Georgieva1, C. H. Borchers2
and J. A. Swenberg1. 1Environmental Sciences
and Engineering, University of North Carolina at
Chapel Hill, Chapel Hill, NC, 2Biochemistry and
Biophysics, University of North Carolina at Chapel
Hill, Chapel Hill, NC and 3R. L. Juliano Structural
Bioinformatics Core, University of North Carolina
at Chapel Hill, Chapel Hill, NC.
#974
URBAN DUST PARTICULATE MIXTURE
AFFECTS METABOLIC ACTIVATION
OF PAHS IN V79 CELLS IN CULTURE. T.
Musafia-Jeknic and W. M. Baird. Environmental
and Molecular Toxicology, Oregon State University,
Corvallis, OR.
#975
EFFECTS OF TREATMENT WITH
MONOMETHYLARSONIC ACID (MMA-V)
OR DIMETHYLARSINIC ACID (DMA-V) IN
THE DIET OR SODIUM ARSENATE (AS-V) IN
THE DRINKING WATER ON THE BLADDER
EPITHELIUM OF FEMALE F344 RATS. L. L.
Arnold1, M. Lu2, X. C. Le2, N. Clark1, M. Cano1 and
S. M. Cohen1. 1University of Nebraska Med. Ctr,
Omaha, NE and 2University of Alberta, Edmonton,
AB, Canada.
TUESDAY
45th Annual
Meeting & ToxExpo
#976
ARSENITE MAINTAINS GERMINATIVE
STATE OF EPIDERMAL CELLS BY
ALTERING WNT SIGNALING. T. J. Patterson
and R. H. Rice. Pharmacology and Toxicology, UC
Davis, Davis, CA.
#977
CARCINOGENIC CR(VI) AND THE
NUTRITIONAL SUPPLEMENT CR(III)
INDUCE DNA DELETIONS IN YEAST AND
MICE. Z. Sobol, R. Reliene and R. H. Schiestl.
Pathology, David Geffen School of Medicine at
UCLA, Los Angles, CA.
#978
DYNAMIC MUTATIONAL FINGERPRINT
OF ACQUIRED DAMAGE IN CANCERS
FROM SUBJECTS EXPOSED TO
TRICHLOROETHYLENE. S. D. Finkelstein, P.
A. Swalsky and M. M. Wilson. RedPath Integrated
Pathology, Pittsburgh, PA. Sponsor: G. Perdew.
#980
THE ROLE OF THE AHR IN BENZENEINITIATED TOXICITY: BENZENE,
HYDROQUINONE AND BENZOQUINONE
DO NOT INDUCE DRE ACTIVATION OR
CYP1A1 EXPRESSION. H. Badham1 and L. M.
Winn1, 2. 1Pharmacology and Toxicology, Queen’s
University, Kingston, ON, Canada and 2School
of Environmental Studies, Queen’s University,
TUESDAY
#982
#983
POSTER SESSION: BIOINFORMATICS
Chairperson(s): Timothy Zacharewski, Michigan State University, East
Lansing, MI.
A CRUCIAL ROLE OF NRF2 IN IN
VIVO DEFENSE SYSTEM AGAINST
AN ENVIRONMENTAL POLLUTANT,
PENTACHLOROPHENOL EXPOSURE. Y.
Kuroiwa1, T. Umemura1, Y. Kitamura1, Y. Ishii1, 3,
K. Kanki1, Y. Kodama2, K. Itoh4, M. Yamamoto4, A.
Nishikawa1 and M. Hirose1. 1Divison of Pathology,
National Institute of Health Sciences, Tokyo, Japan,
2
Divison of Toxicology, National Institute of Health
Sciences, Tokyo, Japan, 3Pharmaceutical Science,
Hoshi University, Tokyo, Japan and 4Center for
TARA, University of Tsukuba, Tsukuba, Japan.
Sponsor: M. Ema.
#979
#981
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
GENETIC DAMAGE FROM THE BENZENE
METABOLITE HYDROQUINONE IN HUMAN
BLOOD STEM AND PROGENITOR CELLS.
L. Zhang, W. Guo, L. Li, X. Zhao and M. T. Smith.
School of Public Health, University of California,
Berkeley, CA.
SUBCHRONIC URINARY BLADDER
EFFECTS OF MURAGLITAZAR IN MALE
RATS. T. Van Vleet1, R. White1, T. Sanderson1, C.
R. Waites1, B. Schilling1, J. Mitroka2, M. Cano3, L.
Arnold3, S. Cohen3 and M. Dominick1. 1Drug Safety
Evaluation, Bristol-Myers Squibb, Evansville,
IN, 2Nonclinical Pharmacokinetics, Bristol-Myers
Squibb, Princeton, NJ and 3Department of Pathology
and Microbiology, University of Nebraska Medical
Center, Omaha, NE.
A BIOLOGICALLY PLAUSIBLE MODE
OF ACTION FOR FORMALDEHYDEINDUCED LYMPHOHEMATOPOIETIC
MALIGNANCIES. D. DeVoney, J. J. Vandenberg
and J. E. Whalan. NCEA, U.S. EPA, Washington,
DC.
136
#984
THE MOUSE GENOME INFORMATICS
DATABASE: APPLICATIONS FOR
TOXICOLOGISTS. S. M. Bello, C. L. Smith,
H. Dene, D. L. Burkart, L. L. Washburn, I. Lu, M.
Tomczuk, A. Anagnostopoulos, B. Richards-Smith,
M. Cassell, H. Onda and J. T. Eppig. Mouse Genome
Informatics, The Jackson Laboratory, Bar Harbor,
ME. Sponsor: M. Hahn.
#985
DATA VISUALIZATION METHODS FOR
COMPARATIVE TOXICOGENOMICS. S.
Hung1, 2, L. D. Burgoon1, 2, 3, J. Kwekel1, 2, 3, D. R.
Boverhof1, 2, 3, E. Dere1, 2, 3, C. J. Fong1, 2, 3, W. Lang1, 2
and T. Zacharewski1, 2, 3. 1Biochemistry & Molecular
Biology, Michigan State University, East Lansing,
MI, 2National Food Safety & Toxicology Center,
3
#986
MICROARRAY DATABASES: DATA
FORMATS, STORAGE, ORGANIZATION
AND ANALYSIS. FIRST EXPERIENCE
WITH ARRAYTRACK. D. Soelle and J. Borlak.
Fraunhofer Institut of Toxicology and Experimental
Medicine, Hannover, Germany.
#987
MOTIF TECHNOLOGY AND APPLICATIONS
IN UNDERSTANDING THE MECHANISM
OF DRUG TOXICITY AND ACTION. A.
Vladimirova, J. Yang, M. Lee, S. Dunlea, B.
Eynon, M. Ghosh, J. Calvin, S. Tugendreich, R.
Brennan, M. Fielden, B. Ganter, K. Kolaja, G.
Natsoulis, C. Pearson, A. Tolley and A. Roter. Iconix
Pharmaceuticals, Mountain View, CA.
#988
ENHANCEMENT OF CANINE
TOXICOGENOMIC-BASED MICROARRAY
DATA ANALYSIS BY AUGMENTING
GENOMIC ANNOTATION. Q. Liu2, P. Yue2,
J. Campbell2, A. Shlionska2 and L. Mertz2.
1
Toxicogenomics, Gene Logic Inc., Gaithersburg,
MD and 2Research and Development, Gene Logic
Inc., Gaithersburg, MD. Sponsor: W. Mattes.
#989
TOXICOGENOMICS COMPARISON OF THE
SPECIES DIFFERENCE OF PPARALPHA
LIGAND. A. Ono1, T. Urusidani1, T. Miyagishima1
and T. Nagao2. 1National Institute of Biomedical
Innovation, Osaka, Japan and 2National Institute of
Health Sciences, Tokyo, Japan. Sponsor: T. Inoue.
45th Annual
Meeting & ToxExpo
#991
#992
GENOME REANALYSIS OF ARYL
HYDROCARBON RECEPTOR BATTERY
GENES: RECONCILIATION OF CURRENT
AND PAST REGULATORY REGION
ANNOTATIONS. L. D. Burgoon1, 2, 3 and T.
Zacharewski1, 2, 3. 1Biochemistry & Molecular
MI, 2National Food Safety & Toxicology Center,
3
THE ABCC GRID PROMOTER TFSITE
COMPARISON PAGE TO FIND SHARED
REGULATORY ELEMENTS FOR COREGULATED GENES IN TOXICOLOGY.
G. Patton2, 1, I. A. Sidorov2, D. S. Dimitrov2, X.
Xiao2, R. H. Shoemaker2, G. Tudor1, D. Covell2
and R. M. Stephens3. 1ORD/NCEA/IRIS, U.S.
EPA, Washington, DC, 2National Cancer Institute
- Frederick, Frederick, MD and 3SAIC, Frederick,
MD.
APPLICATION OF LITERATURE MINING TO
TOXICOGENOMICS. J. Polman1, R. Frijters1, S.
Verhoeven1, M. Krajnc-Franken2 and V. Proutski1.
1
Molecular Design & Informatics, Organon, Oss,
Netherlands and 2Pharmacology, Organon, Oss,
Netherlands. Sponsor: H. Joosten.
#998
THE COMPARATIVE TOXICOGENOMICS
DATABASE (CTD). C. Mattingly1, M.
Rosenstein1, A. Davis1, J. Forrest2, 1 and J. Boyer2,
1 1
. Bioinformatics, MDI Biological Laboratory,
Salisbury Cove, ME and 2Medicine, Yale University
School of Medicine, New Haven, CT. Sponsor: W.
Toscano.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: ACETAMINOPHEN
Chairperson(s): Patricia Ganey, Michigan State University, East Lansing,
MI and Jose Manautou, University of Connecticut, Storrs, CT.
HEPATOCYTE SUBPOPULATIONS SORTED
FROM ACETAMINOPHEN-TREATED MICE.
C. White, M. Dabrowski, C. Fernandez, D. Botta, R.
Beyer, T. Bammler and T. Kavanagh. Environmental
#993
GENOMIC EFFECTS OF DIET
RESTRICTION AND DRUG-INDUCED
HEPATOTOXICITY IN MALE RAT LIVER.
S. Burel1, M. Fielden2, A. Fan1, R. Lum1, K.
Gungon1, P. Cauntay1, M. Weigele1 and A. Sacaan1.
1
Preclinical, Neurocrine Biosciences, San Diego, CA
and 2Iconix Pharmaceuticals, Mountain View, CA.
#994
PATHWAY ANALYSIS AND COMPARISON
OF TWO IN VITRO MICROARRAY STUDIES
OF VASCULITIS INDUCING COMPOUNDS
USING HUMAN AND RAT ENDOTHELIAL
CELLS. B. lu1, B. Enerson1, Y. Zhou2, G. Floyd1 and
M. Lawton1. 1Safety Sciences, Pfizer, Groton, CT
and 2Safety Sciences, Pfizer Inc., Nagoya, Japan.
#995
INVESTIGATION OF THE MOLECULAR
MECHANISM OF HEPATOTOXICITY OF
A G-PROTEIN COUPLED RECEPTOR
ANTAGONIST USING TOXICOGENOMICS.
A. Roberts. Toxicology, Sanofi-Aventis
Pharmaceuticals, Malvern, PA.
#996
COMPUTATIONAL IDENTIFICATION OF
REGULATORY RESPONSE ELEMENTS
IN THE GENOMIC SEQUENCE OF TCDDINDUCED CO-REGULATED HEPA1C1C7
PRIMARY RESPONSE GENES. W. Lang1, 2, L.
D. Burgoon1, 2, 3, E. Dere1, 2 and T. Zacharewski1, 2, 3.
1
Biochemistry & Molecular Biology, Michigan State
University, East Lansing, MI, 2National Food Safety
& Toxicology Center, Michigan State University,
East Lansing, MI and 3Center for Integrative
Toxicology, Michigan State University, East
Lansing, MI.
#997
137
#999
REOVIRUS EXPOSURE POTENTIATES
ACETAMINOPHEN HEPATOTOXICITY. C. J.
Amuzie1, 2, M. Li2, P. E. Ganey2, 1, R. A. Roth2, 1, C.
F. Cuff3 and J. J. Pestka2, 1. 1Comparative Medicine
and Integrative Biology, Michigan State University,
East lansing, MI, 2Center for Integrative Toxicology,
Michigan State University, East lansing, MI and
3
Department of Microbiology and Immunology,
West Virginia University, Morgantown, WV.
#1000
WHOLE BLOOD CARRIES GENE
EXPRESSION SIGNATURES INDICATIVE OF
APAP-INDUCED TOXICITY. A. N. Heinloth1,
J. Parker2, J. Chou1, G. Boorman3, R. Irwin3, M.
Cunningham3, M. Snell3, R. Tennant1 and R. S.
Paules1. 1NCT, NIEHS, Research Triangle Park, NC,
2
Constella, Research Triangle Park, NC and 3ETP,
#1001
INDUCTION OF MRP4 AFTER
ACETAMINOPHEN TREATMENT IS
INDEPENDENT OF CAR AND PXR
EXPRESSION. L. M. Aleksunes1, W. Huang2, L.
M. Augustine3, M. Goedken1, N. J. Cherrington3,
D. D. Moore2 and J. E. Manautou1. 1Department
Storrs, CT, 2Department Mol. and Cell. Bio., Baylor
College of Medicine, Houston, TX and 3Department
Arizona, Tucson, AZ.
#1002
HEPARIN ATTENUATES ACETAMINOPHENINDUCED HEPATOTOXICITY IN MICE.
T. M. Eagle1, S. W. Newport1, J. F. Maddox1,
J. P. Luyendyk2, P. E. Ganey1 and R. A. Roth1.
1
Pharmacology & Toxicology, Michigan State
University, East Lansing, MI and 2Immunology, The
Scripps Research Institute, La Jolla, CA.
TUESDAY
#990
45th Annual
Meeting & ToxExpo
#1003
NUCLEAR TRANSLOCATION OF
ENDONUCLEASE G AND APOPTOSISINDUCING FACTOR DURING
ACETAMINOPHEN HEPATOTOXICITY. M.
Bajt1, C. Cover1, J. J. Lemasters2 and H. Jaeschke1.
1
Liver Research Institute, University of Arizona,
Tucson, AZ and 2University of North Carolina,
Chapel Hill, NC.
#1004
ROLE OF CYP3A IN ACETAMINOPHEN
HEPATOTOXICITY IN WILD-TYPE AND
CYP2E1(-/-) MICE. K. K. Wolf1, S. G. Wood3, J.
A. Hunt3, J. L. Allard3, H. Yohe3, 1, S. X. Duan4, J.
G. Szakacs5, L. L. von Moltke4, D. J. Greenblatt4,
M. H. Court4, S. A. Wrighton6, E. H. Jeffery7, V.
Kostrubsky8, F. J. Gonzalez9, P. R. Sinclair3, 2, 1 and
J. F. Sinclair3, 2, 1. 1Pharmacology and Toxicology,
Dartmouth Medical School, Hanover, NH,
2
Biochemistry, Dartmouth Medical School, Hanover,
NH, 3VA Medical Center, White River Junction,
VT, 4Pharmacology and Experimental Therapeutics,
Tufts University, Boston, MA, 5Harvard Vanguard
Medical Associates, Boston, MA, 6Drug Disposition,
Lilly Research Laboratories, Indianapolis, IN, 7Food
Science and Human Nutrition, University of Illinois,
Urbana, IL, 8Safety Science, Pfizer Global R&D,
Ann Arbor, MI and 9Metabolism, NCI, Bethesda,
MD.
#1005
#1006
TUESDAY
#1007
#1008
#1009
COMPARISON OF S-ADENOSYLL-METHIONINE (SAME) AND
N-ACETYLCYSTEINE (NAC) EFFECT ON
ACETAMINOPHEN MEDIATED INDUCTION
OF TOXICITY IN MICE. M. Terneus1, K.
Kiningham1, A. Prince2 and M. Valentovic1.
1
Pharmacology, Marshall University School of
Medicine, Huntington, WV and 2West Virginia
Wesleyan College, Buckhannon, WV.
#1010
HEPATOPROTECTIVE INTERLEUKIN-13
DIVERSELY AFFECTS CYTOKINES AND
CHEMOKINES IN ACETAMINOPHENINDUCED MURINE LIVER DISEASE. S. B. Yee,
M. Bourdi and L. R. Pohl. Laboratory of Molecular
Immunology, NHLBI, National Institutes of Health,
Bethesda, MD.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: KINASE SIGNALING
Chairperson(s): James Pestka, Michigan State University, East Lansing,
MI and Min Ding, National Institute for Occupational Safety and Health,
Morgantown, WV.
HEPATIC FIBRIN DEPOSITION
DURING THE DEVELOPMENT OF
LIPOPOLYSACCHARIDE-POTENTIATED
ACETAMINOPHEN TOXICITY. S. W. Newport1,
2, 3
, T. M. Eagle1, 2, 3, P. E. Ganey1, 2, 3, R. A. Roth1, 2, 3
and J. F. Maddox1, 2, 3. 1Pharmacology & Toxicology,
Michigan State University, East Lansing, MI,
2
National Food Safety & Toxicology Center,
3
ALTERED PROTEIN EXPRESSION OF
TRANSPORTERS IN THE LIVER OF
PATIENTS FOLLOWING ACETAMINOPHEN
OVERDOSE. S. Barnes1, L. M. Aleksunes1, G.
Scheffer2, I. Pruimboom-Brees3 and J. E. Manautou1.
1
Department of Pharmacology Sciences., University
of Connecticut, Storrs, CT, 2Department of
Pathology, VU Medical Center, Amsterdam,
Netherlands and 3Safety Sciences, Pfizer Global
Research and Development, Groton, CT.
REDUCED HEPATOTOXICITY OF
ACETAMINOPHEN IN CAVEOLIN-1 (CAV-1)
KNOCKOUT MICE IS ASSOCIATED WITH
INCREASED TISSUE REPAIR. C. R. Gardner1,
3
, J. P. Gray1, 3, J. M. Dubois1, 3, J. D. Laskin2, 3 and
D. L. Laskin1, 3. 1Rutgers University, Piscataway, NJ,
2
UMDNJ-RWJ Med. School, Piscataway, NJ and
3
EOHSI, Piscataway, NJ.
TYPE 2 DIABETIC MICE ARE
PROTECTED FROM ACETAMINOPHEN
HEPATOTOXICITY. S. P. Sawant1, A. V.
Dnyanmote1, M. S. Mitra1, J. Chilakapati1, J. R.
Latendresse2 and H. M. Mehendale1. 1Department
.of Toxicology, University of Louisiana Monroe,
Monroe, LA and 2NCTR, Jefferson, AR.
138
#1011
RAPID ANALYSIS OF SRC SIGNALING
PATHWAYS VIA CHEMICAL RESCUE. P. A.
Cole. Pharmacology and Molecular Sciences, Johns
Hopkins University, Baltimore, MD. Sponsor: J.
Kramarik.
#1012
PROTEIN KINASES ASSOCIATE
WITH RIBOSOMES DURING THE
DEOXYNIVALENOL-INDUCED RIBOTOXIC
STRESS RESPONSE IN THE MACROPHAGE.
H. Bae1 and J. Pestka1, 2. 1Department of Food
Science and Human Nutrition, Michigan State
East Lansing, MI.
#1013
A COMPARISON OF THE EFFECTS OF CELL
PERMEABLE FRATTIDE AND A SELECTIVE
GSK3β INHIBITOR ON PROLIFERATION. J. P.
Bailey and M. A. Davis. Investigative Toxicology, Eli
Lilly and Company, Greenfield, IN.
#1014
MECHANISM OF PROTEIN TYROSINE
PHOSPHATASE INHIBITION IN HUMAN
AIRWAY EPITHELIAL CELLS (HAEC)
EXPOSED TO ZN2+ T. L. Tal1, L. M. Graves2, 1,
R. Silbajoris3 and J. M. Samet3, 1. 1Curriculum in
Toxicology, UNC-Chapel Hill, Chapel Hill, NC,
2
Pharmacology, UNC-Chapel Hill, Chapel Hill, NC
and 3Human Studies Division, NHEERL, Chapel
Hill, NC. Sponsor: I. Jaspers.
#1015
THE ROLE OF THE IKK AND THE JNK
PATHWAYS IN ARSENIC TOXICITY. Z. Peng,
L. Peng and Y. Xia. University of Cincinnati,
Cincinnati, OH.
45th Annual
Meeting & ToxExpo
#1017
THE EFFECTS OF PROTEIN ALKYLATION
ON C-JUN N-TERMINAL KINASE
SIGNALING. C. R. Orton2, 1 and D. C. Liebler1.
1
Biochemistry, Vanderbilt University, Nashville, TN
and 2Pharmacology and Toxicology, University of
Arizona, Tucson, AZ.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: RESPIRATORY TRACT IRRITATION,
INFECTION AND INFLAMMATORY INJURY
HIGH-LEVEL OF INORGANIC PHOSPHATE
INDUCE ANGIOGENESIS AND APOPTOSIS
THROUGH AKT PATHWAY AND ERK-MNK
SIGNALING PATHWAY IN VIVO AND IN
VITRO LUNG SYSTEM. S. Chang, H. Jin and M.
Cho. Toxiclogy, College of Veterinary Medicine,
Seoul National University, Seoul, South Korea.
Chairperson(s): Dan Morgan, NIEHS, Research Triangle Park, NC and
Madhusodana Nambiar, Walter Reed Army Institute, Silver Spring, MD.
#1018
LOW INORGANIC PHOSPHATE
DIET REGULATED BRAIN GROWTH
THROUGH AKT SIGNALING PATHWAY
IN TRANSGENIC MICE EXPRESSING
BICISTRONIC LUCR-C-MYC-IRES-LUCF
REPORTER GENE. H. Jin, S. Hwang and M. Cho.
Toxiclogy, College of Veterinary Medicine, Seoul
National University, Seoul, South Korea.
#1019
ESSENTIAL ROLE OF PROTEIN KINASE
C IN SILICA-INDUCED MAP KINASE AND
AP-1 ACTIVATION. M. Ding, Y. Lu, L. Bowman,
V. Castranova and V. Vallyathnan. Pathology and
Physiology Research Branch, National Institute for
Occupational Safety and Health, Morgantown, WV.
#1020
TUMOUR-PROMOTING ACTIVITY
OF MICROCYSTINS DURING
HEPATOCARCINOGENESIS IN
RATS: EFFECTS ON MAPKS SIGNAL
TRANSDUCTION AND GSTPI EXPRESSION.
J. Zhao1, 2, S. Jiang1, W. Qu1 and H. Zhu1.
1
Environmental Health, Fudan University, Shanghai,
China and 2EOH, University of Pittsburgh,
Pittsburgh, PA.
#1021
TYROSINE KINASE-MEDIATED
ACTIVATION OF MITOGEN ACTIVATED
PROTEIN KINASES BY A DIORTHCHLORIANTED PCB IN LIVER
EPITHELIAL CELLS. B. V. Madhukar, G. Chen
and B. F. Wood. Pediatrics/Human Development,
#1022
SPLENOTOXIC RESPONSE OF ANILINE IS
ASSOCIATED WITH EARLY ACTIVATION OF
MITOGEN-ACTIVATED PROTEIN KINASES.
J. Wang and M. Khan. Pathology, University of
Texas Medical Branch, Galveston, TX.
139
#1023
EFFECT OF HEAVY NET SULFUR
POLLUTION ON RESPIRATORY
CHARACTERISTICS OF WORKERS
EXPOSED TO VOLCANIC EMISSIONS
ON MIYAKE ISLAND IN JAPAN. H. Uno,
H. Horiguchi and F. Kayama. Division of
Environmental Medicine, Center for Community
Medicine, Jichi Medical School, Tochigi, Japan.
Sponsor: T. Yoshida.
#1024
FLORIDA RED TIDE BREVETOXINS
CAUSE PULMONARY EFFECTS THROUGH
MULTIPLE MECHANISMS. D. Baden1, S.
Michelizza1 and W. Abraham2. 1UNCW Center for
Marine Science, Wilmington, NC and 2Department
of Research, Mount Sinai Medical Center, Miami
Beach, FL.
#1025
ACUTE NOSE-/HEAD-ONLY EXPOSURE
OF RATS AND DOGS TO PHOSGENE.
CONCENTRATION X TIME DEPENDENCE
OF NON-LETHAL-THRESHOLD
CONCENTRATIONS, INDICATORS
OF PULMONARY IRRITATION IN
BRONCHOALVEOLAR LAVAGE, AND
ANALYSIS OF BREATHING PATTERNS. J.
Pauluhn. Toxicology, Bayer HealthCare, Wuppertal,
Germany.
#1026
SITE-SPECIFIC DEFINITION OF
ACUTE AIRWAY EPITHELIAL INJURY
FOLLOWING A SINGLE EXPOSURE TO 1NITRONAPTHALENE-COATED CARBON
BLACK PARTICLES. M. V. Fanucchi, L. Davison,
B. DeLong, C. G. Plopper, I. M. Kennedy and A. R.
Buckpitt. University of California, Davis, CA.
#1027
BENEFICIAL ROLE OF NEUTROPHILS IN
REPAIR FROM 1-NITRONAPHTHALENE
INDUCED LUNG INJURY. L. Sullivan, M.
V. Fanucchi and C. G. Plopper. University of
California, Davis, Davis, CA.
#1028
SATRATOXIN G FROM THE BLACK MOLD
STACHYBOTRYS CHARTARUM EVOKES
OLFACTORY SENSORY NEURON LOSS
AND INFLAMMATION IN THE MURINE
NOSE AND BRAIN. Z. Islam1, 2, 3, J. R. Harkema3
and J. J. Pestka1, 2, 3. 1Food Science and Human
Nutrition, Michigan State University, East Lansing,
MI, 2Department of Microbiology and Molecular
MI and 3Department of Pathobiology and Diagnostic
Investigation, Michigan State University, East
Lansing, MI.
TUESDAY
#1016
45th Annual
Meeting & ToxExpo
#1029
#1030
#1031
#1032
RESPIRATORY TRACT TOXICITY OF
DIACETYL IN C57BL/6 MICE. D. L.
Morgan1, G. Flake2, P. J. Kirby1, L. T. Burka3, S.
R. Kleeberger4, S. Garantziotis4, D. R. Germolec5
and S. M. Palmer4. 1Molecular Toxicology, NIEHS,
Research Triangle Park, NC, 2Experimental
Pathology, NIEHS, Research Triangle Park, NC,
3
Pharmacology and Chemistry, NIEHS, Research
Triangle Park, NC, 4Respiratory Biology, NIEHS,
Research Triangle Park, NC and 5Environmental
Immunology, NIEHS, Research Triangle Park, NC.
IRRITANT-INDUCED STIMULATION
OF NASAL TRIGEMINAL NERVES VIA
PURINERGIC SIGNALING PATHWAYS. R.
Vaughan, M. Lanosa and J. B. Morris. Toxicology
Program, Department of Pharmaceutical Sciences,
University of Connecticut, Storrs, CT.
A COMPARISON OF
EXPOSURE-RESPONSE FOR CAPSAICIN, NVANILLYLNONANOAMIDE, OR OLEORESIN
CAPSICUM AEROSOL INDUCED SENSORY
IRRITATION. D. A. McCaskey1, R. L. Kristovich2,
J. C. Carpin1, P. A. Dabisch1, A. S. Howard2 and E.
C. Kimmel2. 1Operational Toxicology, Edgewood
Chemical and Biological Center, Aberdeen Proving
Ground, MD and 2Operational Toxicology, GeoCenters, Inc., Aberdeen Proving Ground, MD.
THE INFLUENCE OF PARTICLE SIZE ON NVANILLYLNONANOAMIDE (PAVA) AEROSOL
INDUCED SENSORY IRRITATION. E. C.
Kimmel1, R. L. Kristovich1, D. A. McCaskey2,
A. S. Howard1, J. C. Carpin2 and P. A. Dabisch2.
1
Operational Toxicology, Geo-Centers, Inc.,
Aberdeen Proving Ground, MD and 2Operational
Toxicology, Edgewood Chemical and Biological
Center, Aberdeen Proving Ground, MD.
TUESDAY
#1033
ASSESSMENT OF THE OCULAR IRRITANCY
OF OLEORESIN CAPSICUM (OC) AND
RELATED CAPSAICINOIDS IN GUINEA
PIGS. R. L. Kristovich1, P. Dabisch1, M. Horsman2,
D. McCaskey1, A. Howard2, E. Kimmel2, R.
Mioduszewski1 and S. Thomson1. 1Edgewood
Chemical Biological Center, U.S. Army, Aberdeen
Proving Ground, MD and 2Geo-Centers, INC.,
#1034
THE EFFECT OF DRY CARRIER DELIVERY
ON THE EFFICACY AND PULMONARY
EFFECTS OF “SYNTHETIC CAPSAICIN”. J.
C. Carpin1, D. McCaskey1, E. Davis1, E. Kimmel2
and P. Dabisch1. 1Operational Toxicology, Edgewood
CB Center, Aberdeen Proving Ground, MD and
2
SAIC, Abington, MD.
#1035
#1036
THE CYTOTOXICOLOGICAL EFFECTS AND
INFLAMMATORY RESPONSE OF MULTIPLE
LUNG CELL LINES TO JET FUEL. R. H.
Casavant, M. Varney, H. Boeckman, A. Linger
and D. Courson. Naval Health Research Center
Environmental Health Effects Laboratory, WrightPatterson AFB, OH. Sponsor: E. Wilfong.
#1037
CHARACTERIZATION OF BIOCHEMICAL,
CELLULAR, AND PHYSIOLOGICAL
CHANGES FOLLOWING INTRATRACHEAL
ADMINISTRATION OF FLUORESCEIN
ISOTHIOCYANATE TO THE RAT LUNG. B.
Vuillemenot, T. Sweeney, R. Wolff, J. Pfeiffer, C.
Sylvia, Y. Liang, D. Lechuga and G. Lalonde. Life
Sciences, Nektar Therapeutics, San Carlos, CA.
#1038
DICHOTOMOUS EFFECT OF AEROSOLIZED
HYALURONAN IN A HAMSTER MODEL OF
ENDOTOXIN-INDUCED LUNG INJURY. P. P.
Nadkarni, G. S. Kulkarni, J. M. Cerreta and J. O.
Cantor. Pharmacy and Allied Health Professions, St
John’s University, New York. Sponsor: L. Trombetta.
#1039
MOUSE STRAIN DIFFERENCES IN
BERYLLIUM HYPERSENSITIVITY. L.
M. Tarantino1, S. S. Tinkle2 and T. Gordon1.
1
Environmental Medicine, NYU School of
Medicine, Tuxedo, NY and 2NIEHS, Research
Triangle Park, NC.
#1040
MATERNAL ALLERGIC PHENOTYPE
IMPACTS ALLERGIC RESPONSES OF
OFFSPRING. R. Rouse1, A. Penn1, D. Paulsen2 and
D. Horohov3. 1CBS, SVM, LSU, Baton Rouge, LA,
2
PBS, SVM, LSU, Baton Rouge, LA and 3Veterinary
Sciences, University of Kentucky, Lexington, KY.
#1041
MORPHOMETRIC CHARACTERIZATION
OF INFLUENZA-INDUCED EPITHELIAL
INJURY, REGENERATION, AND MUCOUS
CELL METAPLASIA WITH CORRELATION
TO INFLAMMATORY CELL INFILTRATE IN
THE PULMONARY AIRWAYS OF C57BL/6J
MICE. J. Buchweitz1, 3, J. Harkema2, 3 and N.
Kaminski1, 3. 1Pharmacology and Toxicology,
Michigan State University, East lansing, MI,
2
Pathobiology and Diagnostic Investigation,
Michigan State University, East lansing, MI and
3
University, East lansing, MI.
#1042
PRE-EXPOSURE TO ZYMOSAN ENHANCES
LUNG DEFENSE MECHANISMS AND
ACCELERATES THE PULMONARY
CLEARANCE OF A BACTERIAL PATHOGEN
IN RATS. S. Young, J. R. Roberts and J. M.
Antonini. NIOSH, Morgantown, WV.
ACUTE EFFECTS OF VX INHALATION
ON BRONCHOALVEOLAR LAVAGE FLUID
BUTYRYLCHOLINESTERASE AND LUNG
INJURY IN GUINEA PIGS. J. P. Graham1, M.
P. Nambiar1, 3, P. E. Rezk1, T. E. Moran2 and A. M.
Sciuto2. 1Biochemical Pharmacology, Walter Reed
Army Institute of Research, Silver Spring, MD,
2
Medical/Analytical Toxicology, USAMRICD,
Edgewood, MD and 3Medicine, USUHS, Bethesda,
MD.
140
45th Annual
Meeting & ToxExpo
#1043
RADIATION-INDUCED PULMONARY
FIBROSIS: EFFECT OF THE COMBINED
ACTION OF EXTERNAL RADIATION AND
CERIUM-144 ON THE DEVELOPMENT
OF FIBROUS PROCESS IN THE RATS
LUNG. Z. D. Paskalev1 and D. B. Apostolova2.
1
Radiotoxicology, National Center of Radiobiology
and Radiation Protection, Sofia, Bulgaria and
2
Occupational Toxicology, Clinic of Occupational
Diseases, Medical University, Sofia, Bulgaria.
Sponsor: Z. Paskalev.
#1044
TIME COURSE OF LUNG RESPONSE IN
THE MOUSE TO PANCREATIC ELASTASE.
E. N. Potts, J. A. Voynow and W. M. Foster. Duke
University Medical Center, Durham, NC.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
#1049
MAGNETIC NANOPARTICLES INHALATION
TOXICITY IN MICE. J. Kwon1, C. Song2, T.
Yoon3, D. Kim4, J. Kim1, H. Moon1, K. Yu1, S.
Park1, Y. Kang5, K. Han6, D. Han5, M. Choi4, J.
Lee3 and M. Cho1. 1Laboratory of Toxicology,
College of Veterinary Medicine, Seoul National
University, Seoul, South Korea, 2Aerosole Dynamics
Laboratory, Gwangju Institute of Science and
Technology, Gwangju, South Korea, 3Materials
Chemistry Laboratory, School of Chemistry,
Seoul National University, Seoul, South Korea,
4
Nanotechnology & Thermal Processing Laboratory,
School of Mechanical and Aerospace Engineering,
Seoul National University, Seoul, South Korea,
5
Seoul center, Korea Basic Science Institute, Seoul,
South Korea and 6Seoul Toxicology Laboratory,
Seoul, South Korea.
#1050
PULMONARY TOXICITY SCREENING
STUDIES IN MALE RATS WITH M5
RESPIRABLE FIBERS AND PARTICULATES.
D. B. Warheit, K. L. Reed and T. R. Webb. DuPont
Haskell Laboratory for Health and Environment
Sciences, Newark, DE.
#1051
BIODEGRADABILITY OF PARA-ARAMID
RESPIRABLE-SIZED FIBER-SHAPED
PARTICULATES (RFP) IN HUMAN LUNG
CELLS: VALIDATION OF IN VIVO FIBER
SHORTENING IN AN IN VITRO HUMAN
CELLULAR SYSTEM. D. B. Warheit1, K. L.
Reed1, J. D. Stonehuerner2, A. J. Ghio2 and T. R.
Webb1. 1DuPont Haskell Laboratory for Health and
Environmental Sciences, Newark, DE and 2U.S.
EPA, Chapel Hill, NC.
#1052
TOXICOLOGIC ASSESSMENT OF INHALED
ACICULAR MULLITE. J. A. Hotchkiss, S. M.
Krieger, S. A. Wallin and K. D. Nitschke. The Dow
Chemical Company, Midland, MI.
#1053
PULMONARY TOXICITY OF INDIUM
PHOSPHIDE PARTICULATE IN B6C3F1 MICE
AFTER OROPHARYNGEAL ASPIRATION. P.
J. Kirby1, C. J. Shines1, H. C. Price2, G. Taylor2, J.
Everitt3, G. Hill4 and D. L. Morgan1. 1Respiratory
Toxicology, NIEHS, Research Triangle Park, NC,
2
Alion Science and Technology, Inc., Research
Triangle Park, NC, 3Consultant, Research Triangle
Park, NC and 4Experimental Pathology, NIEHS,
#1054
BUTADIENE SOOT INDUCES
AUTOFLUORESCENCE AND
ULTRASTRUCTURAL DAMAGE IN
CULTURED HUMAN RESPIRATORY
EPITHELIAL CELLS AND CAUSES
INFLAMMATION IN MURINE AIRWAYS.
G. Murphy1, W. G. Henk1, D. B. Paulsen2, S. A.
Barker1 and A. Penn1. 1Comparative Biomedical
Sciences, Louisiana State University, Baton Rouge,
LA and 2Pathobiological Sciences, Louisiana State
University, Baton Rouge, LA.
POSTER SESSION: INORGANIC PARTICLES AND FUMES
Chairperson(s): Vince Castranova, CDC-NIOSH, Morgantown, WV and
Jon Hotchkiss, The Dow Chemical Company, Midland, MI.
#1045
INFLUENCE OF PARTICLE SHAPE ON
SILICA TOXICITY IN VITRO: IMPACT OF
SIMULATED LUNG MECHANICS, SURFACE
TREATMENT, AND AGGREGATION. S. C.
Brown1, M. A. Kamal2, N. Nasreen2, V. B. Antony2
and B. M. Moudgil1. 1Materials Science and
Engineering, and Particle Engineering Research
Center, University of Florida, Gainesville, FL and
2
Department of Medicine, University of Florida,
Gainesville, FL. Sponsor: S. Roberts.
#1046
DOES SANDBLASTED METAL ATTENUATE
OR ENHANCE THE TOXICITY OF SILICA
SAND? V. Robinson, V. Castranova, S. Leonard,
M. Barger, D. Pack, G. Feather and V. Vallyathan.
HELD, NIOSH, Morgantown, WV.
#1047
REPEATED INHALATION TOXICITY OF
SYNTHETIC AMORPHOUS SILICAS IN
RATS: EVALUATION OF THEIR TOXICITY
UP TO 3 MONTHS AFTER EXPOSURE. J.
Arts, H. Muijser, E. Duistermaat, K. Junker and F.
Kuper. Toxicology and Applied Pharmacology, TNO
Quality of Life, Zeist, Netherlands. Sponsor: A.
Nordone.
#1048
PATHOLOGICAL STUDY ON THE
PULMONARY TOXICITY INDUCED BY
THE INTRATRACHEALLY INSTILLED
YELLOW SAND IN MICE. A. Shimada, O. Mina,
K. Theerayuth, T. Morita and H. Inoue. Veterinary
Pathology, Tottori University, Tottori-shi, Japan.
141
TUESDAY
45th Annual
Meeting & ToxExpo
#1055
TWO-WEEK INHALATION STUDIES WITH
DISK-SHAPED PARTICLES OF POTASSIUM
OCTATITANATE (TERRACESS TF) IN RATS.
S. Sakai2, A. Tanaka2, D. P. Kelly1, G. Sykes3 and
K. P. Lee4. 1Haskell Laboratory, DuPont Company,
Newark, DE, 2Otsuka Chemical Co., Osaka, Japan,
3
Veterinary Pathology Services, West Grove, PA and
4
Pathology Consulting, Newark, DE. Sponsor: S.
Loveless.
#1056
THE ACUTE EFFECTS OF TUNGSTEN
ALLOYS (WA) ON THE RAT AIRWAY. H.
J. Boeckman, E. W. Johnson, T. L. Naylor, D. P.
Arfsten and E. R. Wilfong. Naval Health Research
Center Detachment Environmental Health Effects
Laboratory, Wright-Patterson AFB, OH.
#1057
ACUTE EFFECT OF STAINLESS STEEL
WELDING FUME INHALATION ON LUNG
INJURY, INFLAMMATION, AND DEFENSE
RESPONSES. J. M. Antonini, S. Stone, B. Chen, J.
R. Roberts, A. Frazer, M. Donlin, J. Cumpston and
D. Frazer. NIOSH, Morgantown, WV.
#1058
#1059
SOLUBLE CHROMIUM IN WELDING
FUME INCREASES SUSCEPTIBILITY TO
PULMONARY BACTERIAL INFECTION IN
RATS. J. R. Roberts and J. M. Antonini. HELD/
PPRB, NIOSH, Morgantown, WV.
#1062
DISEASE-SPECIFIC SUSCEPTIBILITY TO
ACUTE OZONE-INDUCED INJURY AND
INFLAMMATION IN EIGHT RAT STRAINS.
Universtiy of. P. Kodavanti1, M. C. Schladweiler1,
A. D. Ledbetter1, J. Wallenborn2, R. Jaskot1 and
J. H. Richards1. 1ETD/NHEERL/ORD, U.S. EPA,
Research Triangle Park, NC and 2SPH, UNC, Chapel
Hill, NC.
#1063
ACUTE OZONE-INDUCED INFLAMMATORY
GENE EXPRESSION IN THE RAT LUNG
IS NOT RELATED TO LEVELS OF
ANTIOXIDANTS IN THE LAVAGE FLUID. R.
F. Thomas1, M. C. Schladweiler1, A. D. Ledbetter1,
K. Crissman1, J. G. Wallenborn2, J. H. Richards1, R.
Jaskot1, D. Biscocho3, G. E. Hatch1 and Universtiy
of. P. Kodavanti1. 1ETD/NHEERL/ORD, U.S. EPA,
Research Triangle Park, NC, 2SPH, UNC, Chapel
Hill, NC and 3NC State University Raleigh, NC.
#1064
INCREASED SENSITIVITY OF CAVEOLIN-1
KNOCKOUT MICE TO OZONE. D. L. Laskin,
L. Fakhrzadeh and J. D. Laskin. Environmental and
Occupational Health Sciences Institute, Rutgers
University and UMDNJ-Robert Wood Johnson
Medical School, Piscataway, NJ.
#1065
REPEATED EXPOSURES OF HUMAN
RESPIRATORY EPITHELIAL CELLS TO
LOW LEVELS OF OZONE SENSITIZES
THE EFFECTS INDUCED BY SUBSEQUENT
CHALLENGES TO OZONE OR HAPS. M.
Doyle1, K. G. Sexton1, H. Jeffries1 and I. Jaspers2, 1.
1
ESE, UNC-CH, Chapel Hill, NC and 2CEMALB,
UNC-CH, Chapel Hill, NC.
#1066
PRIOR EPISODIC OZONE EXPOSURE
ALTERS MUCOUS CELL METAPLASIA
AND INFLAMMATION IN RESPONSE TO
ACUTE OZONE EXPOSURE IN RAT NASAL
AIRWAYS. S. A. Carey1, R. B. Lundquist1, J. G.
Wagner1, E. M. Postlethwait2, C. G. Plopper3 and
J. R. Harkema1. 1College of Veterinary Medicine,
Michigan State University, East Lansing, MI,
2
School of Public Health, University of Alabama
at Birmingham, Birmingham, AL and 3Center for
Comparative Respiratory Biology and Medicine,
University of California at Davis, Davis, CA.
#1067
OZONE-INDUCED EXACERBATION
OF RESPONSE TO RECOMBINANT
COCKROACH ALLERGEN IN A TLR4DEFICIENT MOUSE MODEL. G. S. Backus1,
2
, C. R. Walker1 and S. R. Kleeberger1. 1Laboratory
of Respiratory Biology, NIEHS/NIH, Research
Triangle Park, NC and 2Curriculum in Toxicology,
UNC, Chapel Hill, NC.
#1068
SYSTEMIC RESPONSES TO INHALED
OZONE IN MICE: CACHEXIA AND DOWNREGULATION OF LIVER XENOBIOTIC
METABOLIZING GENES. V. C. Mathrani, K.
Gohil, N. J. Kenyon and J. A. Last. Pulmonary and
Critical Care Medicine, University of California,
Davis, CA.
COMPARATIVE INFLAMMATORY LUNG
RESPONSE IN A/J AND C57BL/6J MICE
EXPOSED TO STAINLESS STEEL WELDING
FUME. P. C. Zeidler-Erdely, S. Young, J. R. Roberts,
S. H. Reynolds and J. M. Antonini. Health Effects
Laboratory Division, NIOSH, Morgantown, WV.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: OZONE
TUESDAY
Chairperson(s): Ilona Jaspers, University of North Carolina Chapel Hill,
Chapel Hill, NC and Urmila Kodavanti, U.S. EPA, Research Triangle Park,
NC.
#1060
EXAMINING THE INFLAMMATORY
RESPONSES OF HAPS: THE ROLE OF
OZONE AND OTHER PHOTOCHEMICAL
TRANSFORMATION PRODUCTS. K. G.
Sexton1, I. Jaspers2, 1, M. Doyle1, K. de Bruijne1,
S. Ebersviller1 and H. Jeffries1. 1ESE, UNC-CH,
Chapel Hill, NC and 2CEMALB, UNC-CH, Chapel
Hill, NC.
#1061
A GENETIC BASIS FOR INCREASED
SENSITIVITY OF THE NEONATAL MOUSE
LUNG TO OZONE. E. M. Vancza1, K. Galdanes1,
A. Gunnison1, G. Hatch2 and T. Gordon1. 1New York
University School of Medicine, Tuxedo, NY and
2
EPA, Triangle Park, NC.
142
45th Annual
Meeting & ToxExpo
#1069
AIRWAY AND INFLAMMATORY RESPONSES
FOLLOWING IN-UTERO EXPOSURE TO
ENVIRONMENTAL TOBACCO SMOKE ARE
MODIFIED BY POSTNATAL EXPOSURE TO
OZONE. T. A. Akinbiyi, X. Gao, D. J. Bassett and
D. K. Bhalla. Fund/Appl. Sciences, Wayne State
#1070
OZONE-INDUCED LUNG TOXICITY IN RAT
PUPS FOLLOWING IN UTERO EXPOSURE
TO ENVIRONMENTAL TOBACCO SMOKE. S.
G. Han1, D. K. Bhalla2 and C. G. Gairola1. 1Graduate
Center for Toxicology, University of Kentucky,
Lexington, KY and 2Fund/Appl Sciences, Wayne
State University, Detroit, MI.
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
#1077
GENE EXPRESSION PROFILING OF RAT
AND HUMAN PRIMARY CULTURED
HEPATOCYTES IN RESPONSE TO
DRUGS AFFECTING MITOCHONDRIAL
FUNCTIONS. T. Shimizu, A. Ono, T. Miyagishima,
T. Urushidani and T. Nagao. Toxicogenomics
Project, National Institute of Biomedical Innovation,
Ibaraki, Osaka, Japan. Sponsor: T. Inoue.
#1078
GENE EXPRESSION PROFILING IN
RAT LIVER TREATED WITH VARIOUS
HEPATOTOXIC COMPOUNDS INDUCING
COAGULOPATHY. M. Hirode, A. Ono, T.
Miyagishima, T. Urushidani and T. Nagao.
Toxicogenomics Project in Japan, National Institute
of Biomedical Innovation, Ibaraki, Osaka, Japan.
Sponsor: T. Inoue.
#1079
TOXICOGENOMIC APPROACH FOR
EARLY ASSESSMENT OF POTENTIAL
HEPATOCARCINOGENICITY OF
CHEMICALS IN RATS. T. Uehara, A. Ono,
T. Miyagishima, T. Urushidani and T. Nagao.
Toxicogenomics Project, National Institute of
Biomedical Innovation, Ibaraki, Osaka, Japan.
Sponsor: T. Inoue.
#1080
GENE EXPRESSION PROFILING IN RAT
LIVER TREATED WITH COMPOUNDS
WHICH CHANGE PLASMA TRIGRYCERIDE.
K. Omura, A. Ono, T. Miyagishima, T. Urushidani
and T. Nagao. National Institute of Biomedical
Innovation, Ibaraki, Osaka, Japan. Sponsor: T. Inoue.
#1081
COMPARISON OF DIFFERENTIAL GENE
EXPRESSION IN BLOOD AND LIVER OF
LIPOPOLYSACCHARIDE TREATED RATS. R.
D. Fannin, J. T. Auman, M. E. Bruno, S. O. Sieber,
C. J. Tucker, B. A. Merrick and R. S. Paules. National
Center for Toxicogenomics, NIH_NIEHS, Research
Triangle Park, NC.
#1082
GENE EXPRESSION PATTERN ALTERATION
IN GILL FROM ZEBRAFISH EXPOSED TO
NANOPARTICLES. N. Garcia-Reyero1, D. S.
Barber1, K. Hyndman2, D. Evans2, K. Powers4, J.
H. Freedman3 and N. D. Denslow1. 1Physiological
Sciences, University of Florida, Gainesville, FL,
2
Zoology, University of Florida, Gainesville,
FL, 3Laboratory of Molecular Toxicology, ETP,
DIR, NIEHS, Research Triangle Park, NC and
4
Engineering, University of Florida, Gainesville, FL.
#1083
DOXORUBICIN STIMULATES
MITOCHONDRIAL BIOGENESIS AND
DOWNREGULATES MITOCHONDRIAL
GENE TARGETS. J. M. Berthiaume and K.
B. Wallace. Toxicology Graduate Program,
Biochemistry & Mol. Biology, University of
Minnesota, Duluth, MN.
#1084
GENE EXPRESSION ANALYSIS REVEALS
DIFFERENTIAL POLYADENYLATION OF
ORNITHINE DECARBOXYLASE (ODC)
TRANSCRIPTS IN THE KIDNEYS OF CD
VERSUS FISCHER 344 RATS. S. Seidel, S.
Hung, H. Kan and B. B. Gollapudi. Toxicology and
Environmental Research & Consulting, The Dow
Chemical Co., Midland, MI.
POSTER SESSION: TOXICOGENOMICS
Chairperson(s): William Mattes, Gene Logic Inc., Gaithersburg, MD.
#1071
TRANSCRIPTIONPATH, A VALUABLE ASSAY
FOR DIRECT TRANSCRIPTION ANALYSIS,
ACCURATELY QUANTIFIES TOXICOLOGIC
GENE EXPRESSION CHANGES IN SAMPLES
WITH DEGRADED RNA. M. Warren, V.
Alexiadis, B. Egan and P. Labhart. Genpathway, Inc.,
San Diego, CA. Sponsor: Y. Dragan.
#1072
A BASELINE ANIMAL MICROARRAY
DATABASE FOR BIOLOGICAL RESPONSE
IDENTIFICATION AND BIOMARKER
VALIDATION. J. Fostel. NCT, NIEHS ITSS,
Research Triangle Park, NC. Sponsor: S. Pettit.
#1073
RATE-LIMITING STEP ANALYSIS OF
TOXICOGENOMIC DATA. W. B. Mattes, K. K.
Daniels and M. S. Orr. Toxicogenomics, Gene Logic
Inc., Gaithersburg, MD.
#1074
REPRODUCIBILITY OF MICROARRAY
ANALYSIS IN TOXICOGENOMICS STUDIES.
P. Ancian, S. Leuillet, R. El Gana, S. Arthaud, C.
Fisch, S. de Jouffrey and R. Forster. CIT, Evreux,
France.
#1075
COMPARATIVE TESTICULAR
GENE EXPRESSION PROFILING
OF 2-METHOXYETHANOL, 1,
3-DINITROBENZENE AND DI(2ETHYLHEXYL)PHTHALATE IN ADULT
MALE RATS. E. Tonkin, S. Chanda, P. Day-Lollini,
J. Allard and S. Platz. Roche Palo Alto, Palo Alto,
CA.
#1076
DIFFERENTIALLY REGULATED GENES
EXPRESSION IN THE TESTIS OF
SPRAGUE-DAWLEY RATS TREATED WITH
DI(N-BUTYL) PHTHALATE. M. Ahn, H. Kim, J.
Ryu, H. Kim, H. Park, J. Kim and J. Im. College of
Pharmacy, Pusan National University, Busan, South
Korea. Sponsor: I. Yu.
143
TUESDAY
45th Annual
Meeting & ToxExpo
#1085
#1086
#1087
EFFECT OF NEAR-INFRARED LIGHT
THERAPY ON METHANOL INTOXICATIONINDUCED ALTERATIONS IN RETINAL GENE
EXPRESSION. J. T. Eells1, 4, 2, K. D. DeSmet1, M.
M. Henry2, M. T. Wong -Riley3, H. T. Whelan4, 1, J.
VerHoeve5, R. Das6 and M. Jett6. 1Health Sciences,
University of Wisconsin-Milwaukee, Milwaukee,
WI, 2Opthalmology, Medical College of Wisconsin,
Milwaukee, WI, 3Cell Biology, Neurobiology
and Anatomy, Medical College of Wisconsin,
Milwaukee, WI, 4Neurology, Medical College
of Wisconsin, Milwaukee, WI, 5Ophthalmology,
University of Wisconsin-Madison, Madison, WI and
6
Molecular Pathology, Walter Reed Army Institute of
Research, Washington, DC.
#1091
IN VITRO GENE EXPRESSION PROFILING
OF NEPHROTOXIC CHEMICALS IN RAT
PRIMARY RENAL CORTICAL TUBULAR
CELLS. H. Suzuki1, T. Inoue1, T. Matsushita1,
I. Horii2, Y. Hirabayashi3, T. Inoue3 and K.
Kobayashi4. 1Safety Assessment Department,
Chugai Pharmaceutical Co., Ltd., Kamakura, Japan,
2
Worldwide Safety Sciences, Pfizer Japan Inc.,
Aichi, Japan, 3Biological Safety Research Center,
National Institute of Health Sciences, Tokyo, Japan
and 4Research Compliance and Quality Assurance
Coordination Department, Chugai Pharmaceutical
Co., Ltd., Kamakura, Japan.
#1092
CROSS-SPECIES COMPARISON OF
COCAINE-INDUCED GENE EXPRESSION
PROFILES IN RAT AND HUMAN
HIPPOCAMPUS. M. Yoshioka1, D. Mash2, S.
Schenk3 and J. ffrench-Mullen4. 1Toxicogenomics,
Gene Logic Inc., Gaithersburg, MD, 2Department
of Neurology, University of Miami, Miami,
FL, 3School of Psychology, Victoria University
of Wellington, Wellington, New Zealand and
4
Genomics, Gene Logic Inc., Gaithersburg, MD.
Sponsor: W. Mattes.
HISTOLOGICAL AND GENE EXPRESSION
CHANGES IN MICE AFTER EXPOSURE TO
THE LIBBY AMPHIBOLE. E. A. Putnam, M.
Brezinski, A. Groves, A. Smartt and M. Pershouse.
Biomed & Pharmacology Sciences, University of
Montana, Missoula, MT.
#1093
TRANSCRIPTOMIC ANALYSIS OF ZINC
REGULATION IN ZEBRAFISH (DANIO
RERIO). C. Hogstrand1, D. Zheng1, G. P. Feeney2
and P. Kille2. 1Nutritional Sciences Research
Division, King’s College London, London, England,
United Kingdom and 2School of Biosciences,
Cardiff University, Cardiff, Wales, United Kingdom.
Sponsor: D. St. Clair.
SELECTION OF GENES IMPLICATED
IN METHAPYRILENE-INDUCED
HEPATOTOXICITY BY COMPARING
TARGET AND NON-TARGET TISSUE. J.
T. Auman1, J. Chou1, K. Gerrish1, Q. Huang2,
S. Jayadev2, K. T. Blanchard2 and R. S. Paules1.
1
National Center for Toxicogenomics, NIEHS,
Research Triangle Park, NC and 2BoehringerIngelheim, Ridgefield, CT.
#1094
DEVELOPMENT OF CUSTOM DNA
MICROARRAY FOR CYNOMOLGUS
MONKEY TO DETECT EFFECTIVELY
TOXICITY OF COMPOUNDS. R. Ise1, H.
Izumi1, S. Kanazashi1, N. Miyajima2, K. Takami2, A.
Horinouchi2, H. Fukui2, S. Asahi2 and R. Nagata1.
1
Shin Nippon Biomedical Laboratories, Ltd., Tokyo,
Japan and 2Takeda Pharmaceutical Company Ltd.,
Osaka, Japan.
SEARCH FOR MOLECULAR TARGETS
OF DOXORUBICIN INDUCED
CARDIOTOXICITY. R. Zemlin, S. Reymann and
J. Borlak. Fraunhofer Institut of Toxicology and
#1089
MARKED SIMILARITY OF GENE
EXPRESSION PATTERNS INDUCED IN
HEPG2 CELLS BY THREE INHIBITORS
OF PROTEIN SYNTHESIS WITH
DIFFERING MECHANISMS OF ACTION,
CYCLOHEXIMIDE, ANISOMYCIN AND
PUROMYCIN. H. ni1, R. Brown1, P. Kwanyuen1,
H. Colton1, L. Yoon1, C. Hu2, M. Tirmenstein2,
M. Easton1, D. Creech1, N. Cariello1 and K. T.
Morgan3, 1. 1Safety Assessment, GlaxoSmithkline,
Research Triangle Park, NC, 2Safety Assessment,
GlaxoSmithKline Inc., Upper Merion, PA and
3
Drug Safety Assessment, Sanofi-Aventis Inc.,
Bridgewater, NJ.
TUESDAY
#1088
#1090
Tuesday, March 7
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: NERVOUS SYSTEM: DISEASE MODELS
Chairperson(s): Mona Thiruchelvam, Rutgers, Piscataway, NJ and Lewis
Shi, University of Wisconsin, Madison, WI.
GENE EXPRESSION PROFILING
IN LUNG TISSUES FROM MICE
EXPOSED TO CIGARETTE SMOKE,
LIPOPOLYSACCHARIDE, OR SMOKE PLUS
LIPOPOLYSACCHARIDE BY INHALATION.
Q. Meng1, A. M. Brys2, R. Jones2, K. M. Gideon1,
R. A. Renne1 and M. K. Lee1. 1Battelle Toxicology
Northwest, Richland, WA and 2Battelle Biotech
Columbus, Columbus, OH.
144
#1095
SYNTHESIS OF 3, 4-DIHYDROXYPHENYLA
CETALDEHYDE AND ITS REACTIVITY AS
A TOXIC INTERMEDIATE OF DOPAMINE
METABOLISM. J. N. Rees, V. Florang and J. A.
Doorn. Medicinal and Natural Products Chemistry,
The University of Iowa, Iowa City, IA.
#1096
A VALID IN VITRO BLOOD-CSF BARRIER
TRANSPORT SYSTEM FOR BRAIN
TOXICANT TRANSPORT STUDY. L. Z. Shi
and W. Zheng. School of Health Sciences, Purdue
45th Annual
Meeting & ToxExpo
#1097
PRELIMINARY CHARACTERIZATION OF
THE PARK7 KNOCKOUT MOUSE: A NEW IN
VIVO MODEL FOR PARKINSON’S DISEASE.
A. Ashley1, W. H. Hanneman1, 2, R. B. Tjalkens1, 2
and M. E. Legare1, 2. 1Cell and Molecular Biology
Program, Colorado State University, Fort Collins,
CO and 2Environmental and Radiological Health
Sciences, Colorado State University, Fort Collins,
CO.
#1098
FIBRILLAR ALPHA-SYNUCLEIN
SELECTIVELY DAMAGES DOPAMINERGIC
NEURONS IN CULTURE. S. H. Reaney1, Z. Qin2,
L. C. Johnston1, A. L. Fink1, 2 and D. A. Di Monte1.
1
The Parkinson’s Institute, Sunnyvale, CA and
2
University of California, Santa Cruz, CA.
#1099
DOPAMINE INDUCES APOPTOSIS AND
PROTEASOMAL INHIBITION IN A RAT
DOPAMINERGIC MESENCEPHALIC CELL
LINE. K. S. Zafar, S. H. Inayat-Hussain and D. Ross.
School of Pharmacy, University of Colorado Health
Science Center, Denver, CO.
#1100
NEUROCHEMICAL CHARACTERIZATION
OF IL-6-, TNFα- AND IL-6+TNFα-DEFICIENT
MICE. M. H. Goodwill, D. A. Lawrence and R.
F. Seegal. Wadsworth Center, New York State
Department of Health, Albany, NY.
#1101
1-METHYL-4-PHENYLPYRIDINIUMINDUCED ALTERATIONS OF GLUTATHIONE
IN IMMORTALIZED RAT DOPAMINERGIC
NEURONS. D. Drechsel, L. Liang and M. Patel.
Department of Pharmaceutical Sciences, University
of Colorado Health Sciences Center, Denver, CO.
#1102
MODULATION OF MPTP-DEPENDENT
INDUCTION OF INDUCIBLE NITRIC OXIDE
SYNTHASE (NOS2) IN ASTROCYTES BY
NOVEL DI-INDOLYLMETHANE AGONISTS
OF THE PEROXISOME PROLIFERATORACTIVATED RECEPTOR GAMMA (PPAR-γ).
D. L. Carbone1, S. H. Safe2 and R. B. Tjalkens1.
1
Colorado State University, Fort Collins, CO and
2
Veterinary Physiology and Pharmacology, Texas
#1103
ACTIVATION OF THE PROTEASEACTIVATED RECEPTOR-1 MEDIATES THE
PROTECTIVE EFFECTS OF THROMBIN
PRECONDITIONING IN A PARKINSON’S
DISEASE MODEL. J. R. Cannon1, 2, Y. Hua2, R.
F. Keep2, 3, T. Schallert4 and G. Xi2. 1Environmental
Health Sciences, University of Michigan, Ann Arbor,
MI, 2Neurosurgery, University of Michigan, Ann
Arbor, MI, 3Physiology, University of Michigan, Ann
Arbor, MI and 4Psychology, University of Texas,
Austin, TX.
#1104
UNIQUE EXECUTION OF NO-MEDIATED
TOXICITY WITHIN NAïVE AND NGFDIFFERENTIATED PC12 CELLS. C. Brynczka2,
1
and B. Merrick1, 2. 1NCT, NIEHS, Research Triangle
Park, NC and 2Department Env Mol Toxicology,
NCSU, Raleigh, NC.
145
#1105
MICROGLIA ACTIVATION, OXIDATIVE
STRESS AND NEURODEGENERATION IN
THE PARAQUAT MODEL. A. L. McCormack,
D. Bonneh-Barkay, S. H. Reaney, S. Cumine, M. G.
Purisai and D. A. Di Monte. The Parkinson’s Institute,
Sunnyvale, CA.
#1106
MECHANISM OF ACTION OF PARAQUAT
IS DISTINCT FROM THAT OF MPP+
OR ROTENONE IN NEUROBLASTOMA
CELLS STABLY EXPRESSING DOPAMINE
TRANSPORTER. S. Ramachandiran, J.
R. Richardson and G. W. Miller. Center for
Neurodegenerative Diseases, Emory University,
Atlanta, GA.
#1107
TOXICANT EXPOSURES AND ALPHASYNUCLEIN UP-REGULATION IN ANIMAL
MODELS OF PARKINSON’S DISEASE. M. G.
Purisai, A. L. McCormack, M. Isla, W. J. Langston,
L. C. Johnston and D. A. Di Monte. The Parkinson’s
Institute, Sunnyvale, CA.
#1108
PROGRESSIVE NEURODEGENERATION IN A
DEVELOPMENTAL PESTICIDE-EXPOSURE
BASED MODEL OF PARKINSON’S DISEASE.
M. Thiruchelvam, J. Kochar, H. Mehta, E. K.
Richfield and D. A. Cory-Slechta. Department of
Environmental & OccupationalMedicine, Robert
Wood Johnson Medical School - University of
Medicine and Dentistry of New Jersey, Piscataway,
NJ.
#1109
MOLECULAR MECHANISMS UNDERLYING
DOPAMINERGIC CELL DEATH. Z. Xia1, W.
Choi1, H. Klintworth1, S. Hsuan1, S. Kruse2 and R.
Palmiter2. 1Environmetnal and occupational Heath
Sciences, University of Washington, Seattle, WA and
2
Biochemistry, University of Washington, Seattle,
WA.
#1110
MITOCHONDRIAL THIOREDOXIN IN
ROTENONE-INDUCED NEUROTOXICITY. Y.
Chen1, M. Yu1, M. Aschner2, D. P. Jones3 and J. Cai1.
1
Ophthalmology, Vanderbilt University, Nashville,
TN, 2Pediatrics, Vanderbilt University, Nashville, TN
and 3Medicine, Emory University, Atlanta, TN.
#1111
IN VIVO EFFECTS OF THE
ORGANOCHLORINE PESTICIDE
METHOXYCHLOR ON BRAIN
MITOCHONDRIAL RESPIRATION,
HYDROGEN PEROXIDE PRODUCTION,
PROTEIN OXIDATION AND GENE
EXPRESSION. R. Schuh1, 2, R. Gupta2, J. Flaws2
and G. Fiskum1, 2. 1Anesthesiology, University
of Maryland Baltimore, Baltimore, MD and
2
Epidemiology and Preventive Medicine, University
of Maryland Baltimore, Baltimore, MD.
TUESDAY
45th Annual
Meeting & ToxExpo
#1112
#1113
OXIDATIVE DAMAGE AND NIGROSTRIATAL
DOPAMINE DYSFUNCTION FOLLOWING
EXPOSURE TO THE ORGANOCHLORINE
PESTICIDE DIELDRIN. J. M. Hatcher1, J. R.
Richardson1, 2, T. S. Guillot1, A. L. McCormack3,
D. A. Di Monte3, K. D. Pennell4 and G. W. Miller1,
2 1
. Center for Neurodegenerative Disease, Emory
University School of Medicine, Atlanta, GA,
2
Environmental and Occupational Health, Emory
University, Atlanta, GA, 3The Parkinson’s Institute,
Sunnyvale, CA and 4Civil and Environmental
Engineering, Georgia Institute of Technology,
Atlanta, GA.
NEAR-INFRARED LIGHT THERAPY FOR
PARKINSON’S DISEASE. K. DeSmet1, M. M.
Henry2, E. Buchmann3, M. Wong-Riley4, H. T.
Whelan3, 1 and J. T. Eells1, 2, 3. 1Health Sciences,
University of Wisconsin-Milwaukee, Milwaukee,
WI, 2Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI, 3Neurology, Medical College of
Wisconsin, Milwaukee, WI and 4Cell Biology,
Neurobiology & Anatomy, Medical College of
Wisconsin, Milwaukee, WI.
#1114
IS THE DRUG-INDUCED TARDIVE
DYSKINESIA RELATED TO A DIRECT
EFFECT OF ANTIPSYCHOTICS ON
MITOCHONDRIAL FUNCTION? C. Thiffault
and A. R. Lisowski. Abbott Laboratories, Abbott
Park, IL. Sponsor: Y. Yang.
#1115
EFFECTS OF PSYCHOGENIC STIMULATION
ON THE INDUCTION OF MICROGLIAL
AND NEURONAL ACTIVATION DURING
DEMYELINATION AND REMYELINATION.
D. Urbach-Ross1, 2, D. Shi1 and A. Kusnecov1, 2.
1
Rutgers University, Piscataway, NJ and 2Joint
Graduate Program in Toxicology, University of
NJ. Sponsor: K. Reuhl.
TUESDAY
Tuesday, March 7
9:45 AM to 10:45 AM
Room 11B
Tuesday, March 7
9:45 AM to 10:45 AM
Room 11A
INFORMATIONAL SESSION: THE FUNDAMENTALS OF
TOXICOGENOMICS
Presented by Gene Logic
Specifically for those scientist who need the basics. This seminar will
describe the technology and its application to drug development. In addition basic data analysis techniques will be discussed that demonstrate how
to get useful information from whole genome profiling that can exceed
30,000 data points.
Tuesday, March 7
11:00 AM to 12:00 NOON
Room 11B
INFORMATIONAL SESSION: A SOLUTION FOR
TOXICOGENOMICS ANALYSIS & DATA MANAGEMENT
Presented by Rosetta Resolver® System
Pharmaceutical and biotechnology companies have expressed an increasing
desire to utilize gene expression studies in the safety assessment phase
of drug development. A brief case study will be presented highlighting
methods for utilizing gene expression data for biomarker discovery and
risk assessment.
Tuesday, March 7
11:00 AM to 12:00 NOON
Room 11A
INFORMATIONAL SESSION: UNDERSTANDING YOUR
PHARMACOLOGICAL TARGET DISTRIBUTION ACROSS
NORMAL AND DISEASED HUMAN AND ANIMAL TISSUES
Knowing the distribution of your pharmacological targets within large
samples sets of normal human and animal tissues helps establishes which
organ(s) may be affected. This analysis can be extended to diseased
human tissues in order to understand potential specificity of the drug
target providing rapid in silico verification across more than 6000 human
diseased tissues.
INFORMATIONAL SESSION: CONTRACTING BIOANALYSIS
FOR TOX STUDIES AND THE EVOLUTION OF THE COSTING
PROCESS
Tuesday Afternoon
Process by CROs and presented by SFBC International
Contracting of bioanalysis essentially began in the 70’s in support of
generic ANDAs. In those days it made sense to call a CRO and ask “How
much do you charge per sample for HPLC?” Nowadays, tox studies tend to
be small and often only a few hundred or fewer samples are analyzed for a
given method. If the per-sample cost of bioanlaysis, including the cost of
method development and validation, is compared between clinical methods
and tox methods the differences can easily be an order of magnitude.
Tuesday, March 7
12:00 NOON to 1:30 PM
Exhibit Hall
Hall on-site.
146
45th Annual
Meeting & ToxExpo
Tuesday, March 7
12:00 NOON to 1:15 PM
Room 33
Tuesday, March 7
12:00 NOON to 1:30 PM
Room 6F
STUDENT IN VITRO TOXICOLOGY LECTURE: USING IN
VITRO GENOMICS TECHNOLOGY TO ASSESS THE IMPACT OF
CHEMICALS ON CELL SIGNALING NETWORKS
ISSUES SESSION: SAFETY ASSESSMENT OF THE MAJOR
HUMAN METABOLITES
Chairperson(s): Rakesh Dixit, Johnson and Johnson PRD, San Diego, CA.
Lecturer: Kevin Gaido, CIIT Centers for Health Research, Research
Triangle Park, NC.
Round-Table Discussion Panel Members: Rakesh Dixit, Johnson &
Johnson PRD, San Diego, CA. Sidney Nelson, University of Washington,
Seattle, WA. Alfred Tonelli, Johnson and Johnson PRD, Raritan, NJ. Martin
David Green, U.S. FDA, Rockville, MD. Andrew Parkinson, XenoTech,
Lenexa, KS.
Each year the Colgate-Palmolive Company invites all
students and post-doctoral fellows at the SOT Annual
Meeting to attend a luncheon and lecture concerning
alternative research methods at the forefront of toxicology, specifically, methods that address reduction
of use or replacement of whole animals, or the refinement of experimental techniques using whole animal
models. Past recipients of all the Colgate-Palmolive
SOT awards will be special guests.
Students register for this event on the Annual Meeting Registration Form.
A $5 deposit per ticket is required and will be returned at the luncheon
upon presentation of the ticket. Seating is limited.
The lecture will review an important application of in vitro toxicology to
the study of basic mechanistic processes and provide examples of how
new test methods have benefited animal welfare by refining experimental
procedures and reducing animal use. Recent developments in genomics
technology now allow for the comprehensive screening of the impact
of chemicals and pharmaceuticals on complex cell signaling networks
without the use of whole animal systems. The high-throughput requirement of these approaches necessitates use of in vitro cell culture systems.
These high throughput screens provide enormous amounts of data in
the context of mechanistic and predictive toxicology. The tools for this
type of research include a combination of receptor-based reporter gene
assays, gene expression analysis using genome-wide microarrays and
large-scale, loss-of-function and gain-of-function studies using inhibitory
RNA libraries and libraries of full-length genes, respectively. From results
obtained with these tools, a cell signaling pathway can be constructed and
a more comprehensive and mechanistic understanding of the impact of
chemicals on biological systems can be developed. Elucidation of signaling
pathways at the cellular level is not possible in intact animals and identification of mode of action at the molecular level is often important in
explaining disease states or toxicities identified in vivo.
Tuesday, March 7
12:00 NOON to 1:30 PM
Cardiff Room
SPECIAL INTEREST GROUP MEETING/RECEPTION: HISPANIC
ORGANIZATION FOR TOXICOLOGISTS
Metabolites can be responsible for the desired efficacy as well as the
adverse effects. While qualitatively both phase I and phase II metabolic
reactions are fairly conserved across laboratory safety species and humans,
there are often important quantitative differences in the rate and the
extent of metabolism between safety species and humans. If a metabolite
is responsible for toxicity, the quantitative differences in exposure to a
major toxic metabolite between humans and laboratory animals can lead
to misrepresentation of safety margins based on the parent drug exposure.
Non-clinical safety assessment studies are critical to identifying potential toxicity signals for humans and for providing a reasonable assurance
related to the test drug’s safety at proposed clinical doses. Given the use
of high doses (large multiples of the projected human doses) in safety
studies and the fact that the rates of most phase I and phase II reactions
are relatively greater in non-clinical safety species than in humans, it is
expected that in the vast majority of cases there will be adequate coverage
of metabolites both qualitatively and quantitatively in safety studies. In a
small number of cases, when the major vs. minor pathways of metabolism
are dissimilar across species, there may be human specific “unique” or
“dominant metabolites” that may not have been be adequately tested in
non-clinical safety studies.
The U.S. Food and Drug administration has recently issued “Guidance
for Industry: Safety Testing of Drug Metabolites.” The document makes
a serious regulatory attempt to define the major human metabolite(s) and
provides scientific guidance on the safety testing of the major human
metabolites in non-clinical studies. However, the guidance document has
also raised ambiguity and concerns regarding the definition of the major
metabolites as well as the extent of safety studies with human dominant or
unique metabolites. The round-table discussion will provide an academic,
industrial and federal regulatory perspective on the proposed guideline,
including the definition of the major metabolite and the safety testing of
the major metabolites. It is hoped that this scientific round-table discussion
will provide a path forward for an adequate testing the safety of metabolites.
•
Introduction on the Safety Assessment of the Major Metabolites,
Rakesh Dixit, Johnson and Johnson PRD, San Diego, CA.
•
An Academic Perspective on the Safety Testing of the Major
Metabolites, Sidney Nelson, University of Washington, Seattle, WA.
•
An Industry Perspective on the Safety Testing of the Major
Metabolites, Alfred Tonelli, Johnson and Johnson, PRD, Raritan, NJ.
•
The U.S. FDA Regulatory Perspective and the Rationale for the
Guideline, M. David Green, U.S. FDA, CDER, Rockville, MD.
Questions/Answers: Audience
147
TUESDAY
Sponsored by:
The Colgate-Palmolive Company
Animals in Research Committee
45th Annual
Meeting & ToxExpo
Tuesday, March 7
12:15 PM to 1:15 PM
Room 11A
Tuesday, March 7
1:30 PM to 4:30 PM
Room 5B
INFORMATIONAL SESSION: HIGH-CONTENT ASSAYS FOR
IN VITRO TOXICOLOGY
SYMPOSIUM SESSION: ALTERNATIVE MODEL ORGANISMS
FOR THE ANALYSIS OF DEVELOPMENTAL AND MOLECULAR
TOXICOLOGY
Presented by Cellnomics, Inc.
Cellomics Inc., provider of integrated cellular imaging and analysis
systems, invites you to attend this informational session on use of highcontent analysis (HCA) to perform predictive toxicology assays in vitro.
An overview of the platform and its use for hepatotoxicity, genetic toxicity,
and neurotoxicity will be shown.
Tuesday, March 7
12:15 PM to 1:15 PM
Room 11B
INFORMATIONAL SESSION: TOXICOGENOMICS SOLUTIONS
USING ILLUMINA’S BEADARRAY TECHNOLOGY
Presented by Illumina
Illumina offers toxicologists a complete solution for expression profiling,
from whole genome to focused gene set arrays in human, mouse and rat.
This informational session will demonstrate how industry-leading data
quality and cost per sample coupled with unique multi-sample array
formats enable more robust experimental designs and simplified workflows.
Tuesday, March 7
1:30 PM to 2:30 PM
Room 11A
FL and Craig Giroux, Wayne State University, Detroit, MI.
Endorsed by:
In Vitro SS
Reproductive and Development SS
Mammalian organisms have long been a staple of toxicology research
but in recent years there has been a significant increase in the use of
non-mammalian models systems in molecular and developmental toxicology. Alternative model organisms that are in current use include yeast,
invertebrates such as Drosophila and Caenorhabditis elegans, vertebrate
models such as Danio rerio (zebrafish) and Xenopus, and the pant model,
Arabadopsis. The analysis of toxicologically relevant endpoints in these
organisms has several advantages over traditional mammalian systems.
First, many toxicologically relevant pathways are expressed in each
of these organisms that recapitulate the mammalian pathways and full
genomes are available. Second, these organisms develop externally and the
process proceeds rapidly. This makes it possible to observe development
in real-time. Third, due to the size of the organisms, large numbers can be
evaluated making high throughput screening studies possible. Finally, many
of these organisms have banks of defined mutants that can be manipulated
to directly assess protein interactions and gene regulation. Thus, as the
molecular tools continue to be advanced for each of these systems, their
utility in many aspects of toxicology is unlimited. This session is designed
to highlight the use of alternative models in the analysis of signal transduction pathways, development, and genomics.
INFORMATIONAL SESSION: GENECHIP® MICROARRAYS AND
THEIR USE IN TOXICOGENOMICS—PART ONE
#1116
1:30
ALTERNATIVE MODEL ORGANISMS FOR
THE ANALYSIS OF DEVELOPMENTAL AND
MOLECULAR TOXICOLOGY. R. S. Pollenz.
Biology, University of South Florida, Tampa, FL.
Affymetrix GeneChip® products enable toxicologists to understand mechanisms of toxicological response, discover new biomarkers predictive of
toxic outcomes, and understand gene expression changes occurring within
cellular pathways. This seminar will highlight the basic principals of using
GeneChip technology for toxicogenomic research and is designed to help
accelerate your toxicogenomic studies. See page 178 for GeneChip Microarrays and Their Use in Toxicogenomics—Part Two.
#1117
1:35
ROLES FOR THE C. ELEGANS ARYL
HYDROCARBON RECEPTOR HOMOLOG IN
NEURONAL DEVELOPMENT AND IN THE
REGULATION OF SPECIFIC BEHAVIORS.
J. A. Powell-Coffman and H. Qin. Genetics,
Development, and Cell Biology, Iowa State
University, Ames, IA. Sponsor: R. Pollenz.
Tuesday, March 7
1:30 PM to 2:30 PM
Room 11B
#1118
2:10
SIGNATURES OF EXPOSURE AND
PATHWAYS OF SUSCEPTIBILITY: A YEAST
TOOLKIT FOR BIOMARKER DISCOVERY
AND PREDICTION OF MECHANISMS OF
CELLULAR TOXICITY. C. N. Giroux. Institute
of Environmental Health Sciences, Wayne State
#1119
2:45
USING ZEBRAFISH TO UNDERSTAND
THE EFFECTS OF DEVELOPMENTAL
METHYLMERCURY EXPOSURE AND THE
INFLUENCE OF MATERNAL DIET. M. J.
Carvan1, 2, M. L. Rise1, 2 and D. N. Weber2. 1Great
Lakes WATER Institute, University of WisconsinMilwaukee, Milwaukee, WI and 2Marine and
Freshwater Biomedical Sciences Center, University
of Wisconsin-Milwaukee, Milwaukee, WI.
Presented by Affymetrix
TUESDAY
INFORMATIONAL SESSION: NEW AND NOVEL BIOMARKERS
IN NEPHROTOXICITY TESTING
Presented by Biotrin International
Urinary biomarkers that reveal injury to specific parts of the nephron can
lead to earlier, more sensitive identification of nephrotoxicity. Data will
be presented on novel biomarkers for the proximal and distal convoluted
tubules and the renal papillary collecting ducts and their use in nephrotoxicity testing. Come Nephro-Navigate with Biotrin.
148
45th Annual
Meeting & ToxExpo
#1121
3:20
3:55
USING ZEBRAFISH TO UNRAVEL THE
MECHANISM OF DITHIOCARBAMATE
DEVELOPMENTAL TOXICITY. R. L. Tanguay1,
F. Tilton1, J. K. LaDu1, K. R. Svoboda2, H. Teraoka3
and T. Hiraga3. 1Environmental and Molecular
Toxicology, Oregon State University, Corvallis, OR,
2
Biological Sciences, Louisiana State University,
Baton Rouge, LA and 3Department of Toxicology,
Rakuno Gakuen University, Ebetsu, Japan.
A NEMATODE MODEL TO ELUCIDATE
MECHANISMS OF DEVELOPMENTAL
TOXICITY. D. Jackson1, J. Lewis1, S. Anderson4,
E. Gehman3, M. Szilagyi2 and E. Clegg1. 1US Army
Center for Environmental Health Research, Fort
Detrick, MD, 2U.S. EPA, Washington, DC, 3Gold
Belt Raven, Inc., Fort Detrick, MD and 4GeoCenters, Inc., Fort Detrick, MD.
Tuesday, March 7
1:30 PM to 4:30 PM
Room 6C
#1124
2:20
THE ROLE OF KUPFFER CELLS IN
IMMUNE-MEDIATED ADVERSE DRUG
REACTIONS. C. Ju1, Q. You1, L. Cheng1 and T.
P. Reilly2. 1Pharmaceutical Sciences, University of
Colorado Health Sciences Center, Denver, CO and
2
Drug Safety Evaluation, Bristol-Myers Squibb,
Syracuse, NY.
#1125
2:50
ROLE OF THE KUPFFER CELL
IN MODULATION OF HEPATIC
PRENEOPLASTIC LESION GROWTH. L.
M. Kamendulis and J. E. Klaunig. Department of
Pharmacology and Toxicology, Indiana University
School of Medicine, Indianapolis, IN.
#1126
3:20
KUPFFER CELL ACTIVATION BY NONGENOTOXIC CHEMICALS: DOES IT PLAY
A ROLE IN HEPATOCARCINOGENESIS? I.
Rusyn and C. Woods. University of North Carolina at
Chapel Hill, Chapel Hill, NC.
#1127
3:50
ROLE OF THE KUPFFER CELL IN
MEDIATING THE RESPONSE OF THE LIVER
TO LIGANDS FOR PPARα R. Roberts. Safety
Assessment, AstraZeneca, Macclesfield, United
Kingdom.
SYMPOSIUM SESSION: ROLE OF THE KUPFFER CELL IN
MEDIATING HEPATIC TOXICITY AND CARCINOGENESIS
Chairperson(s): James Klaunig, Indiana University, Indianapolis, IN and
Ruth Roberts, AstraZeneca UK, Macclesfield, United Kingdom.
Tuesday, March 7
1:30 PM to 4:30 PM
Room 8
Endorsed by:
Carcinogenesis SS*
This symposium will address the role of the Kupffer cell, the resident
macrophage of the liver, in the induction and/or facilitation of acute and
chronic liver injury. The Kupffer cell plays an important role in the normal
physiology and homeostasis of the liver both as well as participating in the
acute and chronic responses of the liver to toxic compounds. Activation of
Kupffer cells directly or indirectly by toxic agents results in the release of
an array of inflammatory and growth control mediators as well as reactive
oxygen species. This activation appears to modulate acute hepatocyte injury
as well as chronic liver responses including hepatic cancer. Understanding
the role the Kupffer cell plays in the induction of hepatocyte injury is
essential in understanding the mechanisms of the liver injury. Idiosyncratic
drug induced liver disease results in morbidity and mortality and has been a
major detriment to new therapeutic pharmacological development. Modulation of the Kupffer cell response by drugs has been suggested as a cause for
the idiosyncratic response. Similarly, liver damage seen in chronic ethanol
consumption appears to be modulated by Kupffer cell activation. More
recent evidence has noted a contributory role of Kupffer cell activation in
the process of hepatic carcinogenesis. Several nongenotoxic carcinogens,
for example, activate Kupffer cells which results in the release of cytokines
and/or reactive oxygen species that induce hepatocyte cell proliferation and
may enhance clonal expansion of preneoplastic cells leading to neoplasia.
The Kupffer cell therefore appears to play a central role in the hepatic
response to toxic and carcinogenic agents. (Supported by NIH CA100908)
#1122
1:30
ROLE OF THE KUPFFER CELL IN
MEDIATING HEPATIC TOXICITY AND
CARCINOGENESIS. J. E. Klaunig. Pharmacology
and Toxicology, Indiana University, Indianapolis, IN.
#1123
1:50
THE CONTRIBUTION OF KUPFFER
CELL-DERIVED MEDIATORS TO
ACUTE HEPATOTOXICITY. P. E. Ganey1, 2.
1
Pharmacology and Toxicology, Michigan State
East Lansing, MI.
SYMPOSIUM SESSION: USING STRUCTURE-BASED
APPROACHES FOR HAZARD IDENTIFICATION AND RISK
ASSESSMENT
Chairperson(s): Nigel Greene, Pfizer Global Research & Development,
Groton, CT and Robert Kavlock, U.S. EPA, Research Triangle Park, NC.
Endorsed by:
Risk Assessment SS
Social demands to ensure public health and safety from either planned or
accidental exposure to new molecular entities whilst still maintaining a
flow of new and more effective medicines or the necessary commercial
advances in personal products, requires both industry and regulatory
authorities to identify and manage the risks presented by an increasingly
large number of novel compounds. Often these initial assessments are
made in the absence of high quality toxicology data and generating this
data would take many years and millions of dollars for each compound
under review. As a result, the scientific community has been seeking
ways to prioritize these new and existing chemical entities according to
their potential for adverse effects to either humans or the environment.
Structure-based approaches to hazard identification and risk assessment
offer significant advantages for both industry and regulator alike but their
application is not without its drawbacks. On the positive side, these types
of approaches to hazard assessment are very fast and cheap to run once
they have been successfully implemented. In addition, these approaches
offer a highly attractive public relations solution in view of the increasing
demands to refine, reduce or replace animals in laboratory experiments.
However, questions still exist about their ability to accurately distinguish
between toxic and non-toxic molecules and their effectiveness in ensuring
public safety. This symposium will highlight recent experiences and learnings in the practical application of structure-based hazard identification
and/or risk assessment across a broader scope of industry and regulatory
agencies. The presentations will illustrate how structure-based assessments
are being applied towards a variety of potential hazards (genetic toxicity,
149
TUESDAY
#1120
45th Annual
Meeting & ToxExpo
carcinogenicity, skin sensitization, etc.) and how this information is being
used to aid in decision-making (e.g. development, risk management, exposure controls, prioritization of biological testing).
#1128
1:30
USING STRUCTURE-BASED APPROACHES
FOR HAZARD IDENTIFICATION AND RISK
ASSESSMENT. N. Greene1 and R. J. Kavlock2.
1
Safety Sciences Groton, Pfizer Inc., Groton, CT
and 2National Center for Computational Toxicology,
#1129
1:35
CHALLENGES AND APPROACHES
FOR ESTABLISHING PRIORITIES
AND CATEGORIZING HAZARDS FOR
CHEMICALS BY THE U.S. EPA. R. J. Kavlock.
National Center for Computational Toxicology, U.S.
#1130
2:10
ASSESSMENT OF THE GENOTOXIC
POTENTIAL OF PHARMACEUTICAL
IMPURITIES USING STRUCTURE-BASED
METHODS: PRIORITIZING LOW LEVEL
ANALAYTICAL MEASUREMENT AND
CONTROL OF IMPURITIES. K. L. Dobo1, M. O.
Cyr1, N. Greene2 and W. W. Ku1. 1Genetic Toxicology,
Pfizer Global R & D, Groton, CT and 2Molecular
and Investigative Toxicology, Pfizer Global R &D,
Groton, CT.
#1131
#1132
#1133
2:45
3:20
3:55
induced during the initial exposure is likely to be modified by subsequent
exposures. This is presumptive, but based upon the potential for cells and
tissues injured during the initial insult to become more, or perhaps even
less, susceptible to additional injury by a subsequent insult. As a mechanistic explanation for lung injury, O3 and other air pollutants are known
to react with cell membranes within the respiratory tract and initiate a
direct response through oxidative actions. The destruction of protective
mechanisms, either by a direct action of oxidants in the air or through
the effects of inf lammatory mediators, offers an explanation for the
altered susceptibility to complex atmospheres or upon repeat exposures.
Epidemiological studies have also identified greater vulnerability of sensitive populations, such as the children, the elderly and individuals with
cardiopulmonary conditions, to air pollutants. It is suggested that high
ozone levels in the air substantially increase the risk of illness and death
for compromised individuals. Clearly, the role of ozone in the toxicity
of air pollution can not be ignored. A need for reevaluation of current
air quality standards for ozone is recognized, and there is a growing
interest in understanding its contribution to the development of chronic
lung disease. With ozone as the focus, the symposium will address the
above issues, by discussing ozone dosimetry, developmental status of
the respiratory system, cellular and inflammatory mechanisms of lung
injury, human health effects, sensitivity of susceptible populations, modification of particle toxicity in mixed atmospheres and future directions.
A STRATEGY FOR USING STRUCTURE
ACTIVITY RELATIONSHIPS (SAR) FOR
TOXICITY AND SAFETY PHARMACOLOGY
IN PHARMACEUTICAL R&D. L. Mueller.
PRBN-T, F. Hoffmann-La Roche Ltd., Basel,
Switzerland. Sponsor: N. Greene.
THE USE OF STRUCTURE ACTIVITY
RELATIONSHIPS (SAR/ QSAR) IN SKIN
SENSITIZATION RISK ASSESSMENT. P. S.
Kern. Procter Gamble Eurocor, Strombeek-Bever,
Belgium. Sponsor: F. Gerberick.
TUESDAY
EMERGENCE OF (Q)SAR DECISION
SUPPORT INFORMATION IN FDA
APPLICATIONS. E. J. Matthews, N. L. Kruhlak,
R. Benz and J. F. Contrera. Office of Pharmaceutical
Science, Food and Drug Administration, Rockville,
MD.
#1134
1:30
THE WAR ON OZONE IN THE 3RD
MILLENNIUM: TOXICOLOGY AND HEALTH
EFFECTS UPDATE. D. K. Bhalla1 and M.
W. Foster2. 1Fund/Appl. Sciences., Wayne State
University, Detroit, MI and 2Pulmonary and Critical
Care Medicine, Duke University Medical Center,
Durham, NC.
#1135
1:35
WHERE DOES INHALED OZONE GO? J. S.
Ultman, L. Y. Santiago, A. Fassih and A. Ben-Jebria.
Chemical Engineering, Penn State University,
University Park, PA. Sponsor: D. Bhalla.
#1136
2:10
EARLY POSTNATAL LUNG DEVELOPMENT
IS HIGHLY SUSCEPTIBLE TO PERMANENT
DISRUPTION BY OXIDANT STRESS FROM
OZONE EXPOSURE. C. G. Plopper. VM-APC,
University of California, Davis, CA.
#1137
2:45
INFLAMMATORY MECHANISMS IN OZONE
INDUCED MUCOSAL INJURY IN THE LUNG.
D. K. Bhalla. Fund/Appl. Sciences., Wayne State
#1138
3:20
LESSONS LEARNED FROM LABORATORY
EXPOSURE OF HUMANS TO OZONE:
DIFFERENTIAL SUSCEPTIBILITY. W. M.
Foster. Pulmonary & Critical Care Medicine, Duke
University Medical Center, Durham, NC.
#1139
3:55
HUMAN HEALTH EFFECTS OF AMBIENT
OZONE: EPIDEMIOLOGICAL AND
PHYSIOLOGICAL PERSPECTIVE. I. B. Tager.
School of Public Health, Universtiy of. California
Berkeley, Berkeley, CA. Sponsor: D. Bhalla.
Tuesday, March 7
1:30 PM to 4:30 PM
Room 6F
SYMPOSIUM SESSION: THE WAR ON OZONE IN THE 3RD
MILLENNIUM: TOXICOLOGY AND HEALTH EFFECTS UPDATE
Chairperson(s): Deepak Bhalla, Wayne State University, Detroit, MI and
W. Michael Foster, Duke University Medical Center, Durham, NC.
Endorsed by:
Immunotoxicology SS
Inhalation SS*
Occupational and Public Health SS
Although airborne PM has received considerable attention with respect
to health effects, ozone remains a major toxic component of the photochemical smog. It is generally recognized that the properties and potency
of individual toxicants may be modified upon their combination in complex atmospheres. Furthermore, in chronic exposures, a lung response
150
45th Annual
Meeting & ToxExpo
Tuesday, March 7
1:30 PM to 4:30 PM
Room 6D
Tuesday, March 7
1:30 PM to 4:30 PM
Room 6B
WORKSHOP SESSION: DENDRITIC CELLS AND SKIN
SENSITIZATION: BIOLOGICAL ROLES AND USES IN HAZARD
IDENTIFICATION
WORKSHOP SESSION: GENOMICS IN RISK ASSESSMENT:
UTILITY FOR THE CHARACTERIZATION OF MODE OF
ACTION
Chairperson(s): G. Frank Gerberick, Procter & Gamble Company,
Cincinnati, OH.
Chairperson(s): Ines Pagan, U.S. EPA, Research Triangle Park, NC and
Douglas Wolf, U.S. EPA, Research Triangle Park, NC.
Endorsed by:
Dermal Toxicology SS*
In Vitro SS
Endorsed by:
Risk Assessment SS*
Toxicologic and Exploratory Pathology SS
#1140
1:30
DENDRITIC CELLS AND SKIN
SENSITIZATION: BIOLOGICAL ROLES
AND USES IN HAZARD IDENTIFICATION.
G. Gerberick1 and I. Kimber2. 1Procter & Gamble,
Cincinnati, OH and 2Syngenta, Macclesfield, United
Kingdom.
#1141
1:35
LANGERHANS CELLS, CYTOKINES,
INDUCTION OF SKIN SENSITIZATION,
AND ITS MODIFICATION. K. Cooper1, 2, 3.
1
Dermatology, Case Western Reserve University,
Cleveland, OH, 2University Hospitals of Cleveland,
Cleveland, OH and 3VA Medical Center, Cleveland,
OH. Sponsor: F. Gerberick.
#1142
2:10
GENE EXPRESSION CHANGES INDUCED
IN CULTURED DENDRITIC CELLS BY
CHEMICAL ALLERGENS. L. A. Gildea.
Corporate Biotechnology, Procter & Gamble,
Cincinnati, OH. Sponsor: G. Gerberick.
#1143
2:45
APPROACHES TO SKIN SENSITIZATION
HAZARD IDENTIFICATION USING
CULTURED DENDRITIC CELLS. M. J.
Pallardy, D. Antonios, F. Boisleve and S. Kerdine.
Toxicologie, Faculte Pharmacie, University ParisSud, Chatenay-Malabry, France.
#1144
#1145
3:20
3:55
Microarray technologies promise to greatly enhance our ability to describe
pathophysiological processes, including toxicant-induced responses.
Differential gene expression after exposure to a toxicant will allow for
the determination of potential biomarkers of toxicity. These array-based
biomarkers should enable the detection of changes at a very early stage in
the progression of toxicant-induced adverse health effects. The realization
of these promises, however, depends on careful validation, statistical analysis, and corroboration of genomic responses with responses in the intact
organism. Thus, new informatics and analytical methods as well as large
integrated databases are being developed to interpret the vast amount of
biological data and turn it into useful information. Although these technologies are in the developmental stages, both the U.S. EPA and the USFDA
have developed draft guidances and policies that recognize that these data
will ultimately be part of science-based safety and risk assessment decisions. Initially, genomic data shows promise in the characterization of
chemical-specific mode of action (MOA) and in the description of toxicity
pathways that result in adverse health effects. This workshop will present
potential approaches on how genomics could be used to fill data gaps in
the characterization of the MOA used in the assessment of risk posed by
environmental chemicals.
RING TRIALS OF DENDRITIC CELL
SURROGATE CELL LINES. C. Ryan. Procter &
Gamble Company, Cincinnati, OH.
#1146
1:30
GENOMICS IN RISK ASSESSMENT: UTILITY
FOR THE CHARACTERIZATION OF MODE
OF ACTION. I. Pagan and D. C. Wolf. U.S. EPA,
#1147
2:00
THE ROLE OF MODE OF ACTION
INFORMATION IN HUMAN HEALTH RISK
ASSESSMENT. V. Dellarco. U.S. EPA, Washington,
DC.
#1148
2:30
INTEGRATION OF GENOMICS WITH
TRADITIONAL TOXICOLOGY. G. Boorman.
#1149
3:10
DEFINING TOXICOLOGICAL PATHWAYS
FROM INDIVIDUAL BIOMARKERS:
IDENTIFICATION OF TECHNOLOGIES
AND TOOLS CRITICAL IN MOLECULAR
RISK ASSESSMENT. A. Brooks1, 2. 1University of
NJ and 2Rutgers University, Piscataway, NJ.
Sponsor: D. Wolf.
#1150
3:50
BIOLOGICAL PLAUSIBILITY AND
APPLICATION TO RISK ASSESSMENT:
HUMAN RELEVANCE AND DOSERESPONSE ANALYSIS. C. J. Borgert1, 2. 1Applied
Pharmacology and Toxicology, Inc., Gainesville,
FL and 2University of Florida College of Veterinary
Medicine, Gainesville, FL.
DISCUSSION: THE WAY FORWARD. D. A.
Basketter2, G. Gerberick1 and I. Kimber3. 1Procter
& Gamble, Cincinnati, OH, 2Unilever, Sharnbrook,
United Kingdom and 3Syngenta, Macclesfield,
United Kingdom.
151
TUESDAY
The purpose of this Workshop is to describe advances that have been
made in recent years in our understanding of the roles played by cutaneous
dendritic cells in the induction of contact allergy. In addition, the ways
in which such advances in dendritic cell biology have been exploited to
develop alternative approaches to the identification and characterization of
skin sensitizing chemicals will be presented.
45th Annual
Meeting & ToxExpo
Tuesday, March 7
1:30 PM to 4:30 PM
Room 2
WORKSHOP SESSION: POTENTIAL HUMAN HEALTH RISK
FROM ESTROGENIC FOOD AND CONSUMER PRODUCT
ADDITIVES: HOW MUCH IS REAL AND HOW MUCH IS HYPE?
#1155
3:20
PROBLEMS FOR RISK ASSESSMENT OF
ESTROGENIC COMPOUNDS IN THE DIET. S.
Safe. Veterinary Physiology & Pharmacology, Texas
#1156
3:55
SHOULD THE ENDOCRINE DISRUPTORS
BE TOLERATED IN FOODS/COSMETICS
AND, IF SO, AT WHAT LEVELS? G. A. Burdock.
Burdock Group, Washington, DC.
Chairperson(s): Madhu Soni, Burdock Group, Vero Beach, FL.
Endorsed by:
Food Safety SS*
Reproductive and Development SS
Risk Assessment SS
Tuesday, March 7
1:30 PM to 4:30 PM
Room 1B
PLATFORM SESSION: APOPTOSIS
In recent years, decreased sperm count and increased breast cancer rates
have claimed to be associated with man-made and dietary (phyto-) estrogens. Several additives used in foods and other consumer products, such as
isoflavones, UV screens, certain alkylphenols, bisphenol A, some parabens
and certain phthalates have been shown to be weakly estrogenic in in vitro
or in vivo assays. As these chemicals are widely and increasingly used,
there is a growing concern as to their role in reproductive toxicity and
breast cancer. Recent findings on the presence of parabens in human breast
cancer tissue samples have ignited the debate on the role of estrogenic food
additives in the development of cancer and reproductive toxicity. These
findings and dilema created have raised the level of concern with both
consumers and industry. This movement is spreading to a wider audience,
whether there is any basis for concern or not. Several of the food additive
estrogens are also consumed as part of a natural food, however it is not
known what effects may be produced when consumed in isolated/ concentrated/ purified form. The current risk assessment of estrogenic substances
as food additives is performed individually and combined effects of these
substances in the diet are not known. As these substances share a common
mechanism of action, an aggregate risk assessment for each chemical in
the group and a cumulative risk assessment is needed. Additionally, the
contributions of ingredients with antiestrogenic activity in the diet also
needs due considerations. Should the estrogenic substances be added to
foods/consumer products and if so at what levels?
#1151
TUESDAY
#1152
1:30
1:35
Chairperson(s): Valerian Kagan, University of Pittsburgh, Pittsburgh, PA.
POTENTIAL HUMAN HEALTH RISK FROM
ESTROGENIC FOOD AND CONSUMER
PRODUCT ADDITIVES- HOW MUCH IS
REAL AND HOW MUCH IS HYPE? M. G. Soni1
and G. J. Nohynek2. 1Burdock Group, Vero Beach,
FL and 2Global Safety Department, L’oreal Research
and Development, 92600 Asnieres, France.
RISK ASSESSMENT OF OESTROGENIC AND
ANTI-ANDROGENIC SUBSTANCES IN FOOD
CONTACT ARTICLES IN THE EUROPEAN
UNION. S. M. Barlow1, 2. 1Independent Consultant,
Brighton, United Kingdom and 2European Food
Safety Authority, Parma, Italy. Sponsor: M. Soni.
#1153
2:10
OESTROGENIC CHEMICALS IN
COSMETICS AND BREAST CANCER.
P. Darbre. School of Biological Sciences, The
University of Reading, Reading, United Kingdom.
Sponsor: M. Soni.
#1154
2:45
PRESERVATIVES AND ULTRAVIOLET
FILTERS WITH SLIGHT ESTROGENIC
ACTIVITY USED IN IN COSMETICS: IS
THERE A HEALTH RISK? G. J. Nohynek.
Worldwide Safety Evaluation, L’oreal R&D,
Asnieres, Cedex, France.
152
#1157
1:30
1, 1-BIS(3’-INDOLYL)-1-(P-SUBSTITUTED
PHENYL)METHANES ARE PEROXISOME
PROLIFERATOR-ACTIVATED RECEPTOR γ
AGONISTS BUT DECREASE HCT-116 COLON
CANCER CELL SURVIVAL THROUGH
RECEPTOR-INDEPENDENT ACTIVATION
OF EARLY GROWTH RESPONSE-1 AND
NAG-1. S. Chintharlapalli1, S. Papineni2, S. Baek3,
S. Liu4 and S. Safe1, 2, 4. 1Department of Biochemistry
and Biophysics, Texas A&M University, College
Station, TX, 2Department of Veterinary Physiology
and Pharmacology, Texas A&M University,
College Station, TX, 3Department of Pathobiology,
University of Tennessee, Knoxville, TN and
4
Institute of Biosciences and Technology, Texas
A&M University System, Houston, TX.
#1158
1:50
BINDING OF NO AND NITROSYLATION OF
CYTOCHROME C/CARDIOLIPIN COMPLEX
INHIBITS ITS PEROXIDASE ACTIVITY AND
CARDIOLIPIN OXIDATION. I. I. Vlasova1, V.
A. Tyurin1, A. A. Kapralov1, I. V. Kurnikov1, A. N.
Osipov1, M. Potapovich1, D. Stoyanovski2 and V.
E. Kagan1. 1Center for Free Radical & Antioxidant
Health, EOH, University of Pittsburgh, Pittsburgh,
PA and 2Surgery, University of Pittsburgh,
Pittsburgh, PA.
#1159
2:10
INCREASED APOPTOSIS REGULATION
WITH POSTMITOTIC CELLULAR
DIFFERENTIATION. M. Deshmukh. Cell and
Developmental Biology, University of North
Carolina, Chapel Hill, NC. Sponsor: J. Kramarik.
#1160
2:30
PARAQUAT INDUCES OXIDATIVE STRESS,
NEURONAL LOSS IN SN REGION AND
PARKINSONISM IN RATS: NEUROPROTECTION AND AMELIORATION OF
SYMPTOMS BY WATER-SOLUBLE COQ10.
S. Pandey1, M. Somayajulu1, J. Vergel de Dios1, 2, A.
Matei2, V. Parameswarann2, J. Cohen2, J. Sandhu3,
H. Borowy-Borowski3 and M. Sikorska3. 1Chemistry
& Biochemistry, University of Windsor, Windsor,
ON, Canada, 2Psychology, University of Windsor,
Windsor, ON, Canada and 3Institute for Biological
Sciences, National Research Council of Canada,
Ottawa, ON, Canada.
45th Annual
Meeting & ToxExpo
2:50
GLUTATHIONE RELEASE
AND PHOSPHATIDYLSERINE
EXTERNALIZATION DURING APOPTOSIS
ARE DEPENDENT UPON FUNCTIONAL
MULTIDRUG RESISTANCE-ASSOCIATED
PROTEINS, MRPS. R. Marchan, C. L. Hammond,
S. M. Krance and N. Ballatori. Environmental
Medicine, University of Rochester School of
Medicine & Dentistry, Rochester, NY.
Tuesday, March 7
1:30 PM to 4:30 PM
Room 15A
PLATFORM SESSION: ENDOCRINE DISRUPTORS MECHANISMS
Chairperson(s): Tammy Stoker, U.S. EPA, Research Triangle Park, NC and
Vickie Wilson, U.S. EPA, Research Triangle Park, NC.
#1162
3:10
PERINATAL EXPOSURE TO ∆-9TETRAHYDROCANNABINOL (THC)
INDUCES APOPTOSIS IN THE FETAL
THYMUS. C. A. Lombard, M. Nagarkatti and P. S.
Nagarkatti. Pathology and Microbiology, University
of South Carolina, School of Medicine, Columbia,
SC.
#1163
3:30
NITROSATIVE STRESS INDUCES
PHOSPHATIDYLSERINE
EXTERNALIZATION: SIGNALING ROLE
IN PHAGOCYTOSIS. Y. Y. Tyurina2, 1, A.
Potapovich2, 1, V. A. Tyurin2, 1, P. Cai2, 1, N. V.
Konduru2, 1, H. Bayir3, 2, B. Fadeel6, D. Stoyanovsky4,
A. A. Shvedova5 and V. E. Kagan2, 1. 1Center for
Free Radical & Antioxidant Health, University
of Pittsburgh, Pittsburgh, PA, 2EOH, University
of Pittsburgh, Pittsburgh, PA, 3Crit. Care Med.,
University of Pittsburgh, Pittsburgh, PA, 4Surgery,
University of Pittsburgh, Pittsburgh, PA, 5Health
Effects Laboratory Division, NIOSH, Morgantown,
WV and 6Division of Molecular Toxicology,
Karolinska Institute of Env. Med., Stockholm,
Sweden.
#1164
#1165
3:50
4:10
#1166
1:30
ALTERATION OF THE HYPOTHALAMICPITUITARY GONADAL(HPG) AXIS IN
WISTAR MALE RATS FOLLOWING
A PREPUBERTAL EXPOSURE TO THE
CHLOROTRIAZINE HERBICIDE SIMAZINE.
T. E. Stoker, A. Buckalew, J. Ferrell, E. Kaydos and
R. Cooper. EB, RTD, NHEERL, ORD, U.S. EPA,
#1167
1:50
METHOXYCHLOR DELAYS MALE RAT
PUBERTAL ONSET THROUGH ANTIADIPOGENESIS. X. Wang, J. Nicoll and L.
You. Biology, CIIT Centers for Health Research,
#1168
2:10
ACTIVATION OF INTRACELLULAR TRPV1
INDUCES ER STRESS RESPONSE AND CELL
DEATH. K. C. Thomas, M. E. Johansen, P. J. Moos,
G. S. Yost and C. A. Reilly. Pharmacology and
Toxicology, University of Utah, Salt Lake City, UT.
ONTOGENY OF CHANGES IN FETAL
TESTIS GENE EXPRESSION INDUCED IN
MALE OFFSPRING AFTER MATERNAL
TREATMENT WITH DEHP (DIETHYLHEXYL
PHTHALATE). V. S. Wilson1, C. Lambright1, J.
Furr1, K. Bobseine1, C. Wood1, K. L. Howdeshell2
and L. E. Gray1. 1Reproductive Toxicology Division,
U.S. EPA, ORD, NHEERL, Research Triangle
Park, NC and 2EPA./NCSU Cooperative Training
Agreement, North Carolina State University
Raleigh, NC.
#1169
2:30
GONIOTHALAMIN INDUCES APOPTOSIS
IN VASCULAR SMOOTH MUSCLE CELLS.
S. H. Inayat-Hussain1, C. K. Meng1, N. F. Rajab1,
K. Yusoff3, M. H. Ishak1, A. M. Ali2 and L. B. Din1.
1
Environmental Health Programme, Faculty of Allied
Health Sciences, Universiti Kebangsaan Malaysia,
Kuala Lumpur, Malaysia, 2Faculty of Science and
Biotechnology, Universiti Putra Malaysia, Serdang,
Malaysia and 3Faculty of Medicine, Universiti
Teknologi Mara, Shah Alam, Malaysia.
EFFECTS OF BDE-47 ON NUCLEAR
RECEPTOR REGULATED GENES AND
IMPLICATIONS FOR THYROID HORMONE
DISRUPTION. V. Richardson1, D. Staskal2, M.
DeVito1 and L. Birnbaum1. 1ORD/NHEERL/ETD/
PKB, U.S. EPA, Research Triangle Park, NC and
2
Curriculum in Toxicology, UNC at Chapel Hill,
Chapel Hill, NC.
#1170
2:50
SENSITIVE AND COMPOUND-SPECIFIC
BIOMARKERS FOR DIETARY EXPOSURE
TO ESTROGENIC COMPOUNDS. M. Heneweer,
J. H. Poortman, M. J. Groot and A. A. Peijnenburg.
Toxicology and Effectmonitoring, RIKILT - Institute
of Food Safety, Wageningen, Netherlands. Sponsor:
M. VandenBerg.
#1171
3:10
EFFECTS OF PHYTOESTROGENS ON COCULTURES OF THE MCF7 MAMMARY
TUMOR CELL LINE AND PRIMARY HUMAN
MAMMARY FIBROBLASTS. J. V. Meeuwen1,
A. Piersma2 and M. VandenBerg1. 1Cellular &
Molecular Toxicology, IRAS, Utrecht, Netherlands
and 2Laboratory for Toxicology, Pathology and
Genetics, RIVM, Bilthoven, Netherlands.
153
TUESDAY
#1161
45th Annual
Meeting & ToxExpo
#1172
3:30
INTERACTIONS OF INSULIN-LIKE
GROWTH FACTOR-1 RECEPTOR
AND AROMATASE ARE INVOLVED IN
GENISTEIN- AND METHOXYCHLOR
INDUCED EPITHELIAL
HYPERPROLIFERATION IN RAT
MAMMARY GLAND. L. You and X. Wang.
Biology, CIIT Centers for Health Research,
#1173
3:50
TRANSCRIPT PROFILING FOR
STEROIDOGENIC GENES IN THE H295R
CELL LINE AND HUMAN ADRENAL DEVELOPMENT OF A SCREENING TOOL
FOR ADRENOTOXICANTS. A. Oskarsson1,4,
K. A. Plant2, E. Ulleras1, J. P. Hinson3 and P. S.
Goldfarb2. 1Department of Biomedical Sciences and
Veterinary Public Health, Swedish University of
Agricultural Sciences, Uppsala, Sweden, 2School
of Biomedical & Molecular Sciences, University of
Surrey, Guildford, United Kingdom, 3Department
of Endocrinology, St Bartolomews and The
Royal London School of Medicine and Dentistry,
Queen Mary and Westfield College, London,
United Kingdom and 4Reproductive Toxicology
& Distribution Imaging, Safety Assessment, Astra
Zeneca R&D, Sodertalje, Sweden.
#1174
4:10
IN VITRO STEROIDOGENIC METABOLISM
CAN BE INHIBITED BY PBDE DERIVATIVES
(HYDROXY AND METHOXYLATED BDES)
IN HUMAN PLACENTAL MICROSOMES.
R. Fernandez Canton1, D. Scholten1, G. Marsh2,
P. C. Jong3 and M. van den Berg1. 1Cellular and
Molecular Toxicology, IRAS, Utrecht, Netherlands,
2
Department of Environmental Chemistry,
Stockholm University, Stockholm, Sweden and
3
St. Antonius Hospital, Nieuwegein, Utrecht,
Netherlands.
#1177
2:10
GENOTOXICITY OF SOLUBLE AND
PARTICULATE CADMIUM COMPOUNDS.
T. Schwerdtle1, C. Thuy1, W. Bal2 and A. Hartwig1.
1
Institute of Food Technology and Food Chemistry,
Technical University Berlin, Berlin, Germany and
2
Institute of Biochemistry and Biophysics, Polish
Academy of Sciences, Warsaw, Poland. Sponsor: M.
Metzler.
#1178
2:30
CHANGES IN GENE EXPRESSION
ASSOCIATED WITH EXPOSURE TO
ENVIRONMENTAL TOXICANTS. J. H.
Freedman1, M. Chen2, S. Coughlan2 and W. A.
Boyd1. 11Laboratory of Molecular Toxicology, ETP,
DIR, NIEHS, Research Triangle Park, NC and
2
2Agilent Technologies, Inc., Palo Alto, CA.
#1179
2:50
GENE EXPRESSION PROFILE IN HUMAN
SKIN FIBROBLASTS EXPOSED TO
POTASSIUM DICHROMATE. Q. He and P.
Joseph. Health Effects Laboratory Division, NIOSH,
Morgantown, WV.
#1180
3:10
DIVALENT METAL TRANSPORTER-1
REGULATION BY IRON AND VANADIUM
MODULATES HYDROGEN PEROXIDEINDUCED DNA DAMAGE IN LUNG CELLS.
A. R. Molinelli1, A. J. Ghio2 and M. C. Madden2,
1 1
. Curriculum in Toxicology, University of North
Carolina, Chapel Hill, NC and 2NHEERL/HSD, U.S.
EPA, Chapel Hill, NC.
#1181
3:30
TRANSCRIPTOME CHANGES IN
HEPG2 CELLS EXPOSED TO COPPER:
PATHWAY MAPPING AND INTERACTOME
IDENTIFICATION. M. Song1 and J. H. Freedman1,
2 1
. Duke University, Durham, NC and 2NIEHS,
#1182
3:50
SOLUBLE MANGANESE ALTERS
PULMONARY GENE EXPRESSION IN
VIVO. S. Bredow, J. Aden, V. E. Walker and K.
Divine. Lovelace Respiratory Research Institute,
Albuquerque, NM, NM.
#1183
4:10
SIGNIFICANCE OF INTERACTIONS
BETWEEN ESSENTIAL AND TOXIC METAL
IONS IN THE CELLULAR RESPONSE TO
DNA DAMAGE. A. Hartwig1, W. Bal2, H. Blessing1,
T. Schwerdtle1, C. Thuy1 and I. Walter1. 1Institute
of Food Technology and Food Chemistry, Technical
University Berlin, Berlin, Germany and 2Institute of
Biochemistry and Biophysics, Polish Academy of
Sciences, Warsaw, Poland. Sponsor: M. Metzler.
Tuesday, March 7
1:30 PM to 4:30 PM
Room 7A
TUESDAY
PLATFORM SESSION: METALS TOXICOLOGY I
Chairperson(s): Ellen Silbergeld, Johns Hopkins University, Baltimore,
MD and Allen Rosenspire, Wayne State University, Detroit, MI.
#1175
1:30
CHARACTERIZING HUMAN
SUSCEPTIBILITY TO MERCURY-INDUCED
IMMUNOTOXICITY. E. K. Silbergeld, R. M.
Gardner and J. F. Nyland. Environmental Health
Sciences, Johns Hopkins University School of
Public Health, Baltimore, MD.
#1176
1:50
THE MECHANISM OF INORGANIC
MERCURY DISRUPTION OF ERK IN T AND
B LYMPHOCYTES INVOLVES UPSTREAM
ELEMENTS IN THE TCR AND BCR
SIGNAL TRANSDUCTION PATHWAYS. A. J.
Rosenspire1, S. E. Ziemba1, S. Menard1, L. Li3, R.
R. Mattingly2 and M. J. McCabe4. 1Immunology and
Microbiology, Wayne State University, Detroit, MI,
2
Pharmacology, Wayne State University, Detroit, MI,
3
Medicine, Wayne State University, Detroit, MI and
4
Environmental Medicine, University of Rochester,
Rochester, NY.
154
45th Annual
Meeting & ToxExpo
Tuesday, March 7
1:30 PM to 4:30 PM
Room 7B
#1190
3:30
OXIDATION OF INDIGO CARMINE BY
PEROXYNITRITE (± CO2): IMPLICATIONS
FOR THE HYPOTHESIS ON OZONE
PRODUCTION BY NEUTROPHILS. V. Rangan,
T. E. Perumal, K. Sathishkumar and R. M. Uppu.
Environmental Toxicology and Health Research
Center, Southern University and A&M College,
Baton Rouge, LA.
#1191
3:50
COMBINATIVE TOXICITY OF SODIUM
PERCHLORATE AND SODIUM ARSENATE
IN ZEBRAFISH (I)DANIO RERIO(I/):
OXIDATIVE STRESS AND GENOTOXICITY
PERSPECTIVE. F. Liu1, J. Wang1, M. Hooper1 and
C. Theodorakis2. 1Department of Environmental
Toxicology, The Institute of Environmental and
Human Health, Texas Tech Universiyt, Lubbock,
TX and 2Department of Biology, Southern Illinois
University at Edwardsville, Edwardsville, IL.
#1192
4:10
CROSS-LINK BLOCKING AND THE
MECHANISM OF ACTION OF HYDRAZINO
DRUGS AGAINST ACROLEIN TOXICITY.
P. C. Burcham. Pharmacology Unit, University of
Western Australia, Perth, WA, Australia. Sponsor: F.
Grzemski.
PLATFORM SESSION: OXIDATIVE INJURY
Chairperson(s): Mary Beth Genter, University of Cincinnati,
Environmental Health, Cincinnati, OH and Adrian Nicolescu, Queens
University, Kingston, ON, Canada.
1:30
ALTERATION OF HEME-OXYGENASE
EXPRESSION IN A549 CELLS BY URBAN
DUST PARTICULATE MIXTURE 1649A.
A. De Vizcaya-Ruiz, M. Uribe-Ramirez and M.
E. Cebrián. Toxicology Section, CINVESTAVZacatenco, Mexico D.F., Mexico.
#1185
1:50
THIOREDOXIN-MEDIATED AIRWAY
EPITHELIAL CELL PROTECTION FROM
SMOKE THROUGH THE SUPPRESSION OF
JNK PATHWAY. Y. Lee, C. Chuang, P. Lee, J.
Lee, R. Harper and R. Wu. Center for Comparative
Respiratory Biology and Medicine, University of
California at Davis, Davis, CA. Sponsor: J. Last.
#1186
#1187
#1188
#1189
2:10
2:30
2:50
3:10
ANTIOXIDANTS RESCUE HYPEROXIAINDUCED SUPPRESSION OF MACROPHAGE
PHAGOCYTOSIS OF PSEUDOMONAS
AERUGINOSA. L. Mantell1, 2, D. M. Morrow2, 1
and T. Entezari Zaher1, 2. 1Pharmaceutical Sciences,
St Johns University College of Pharmacy, Queens,
NY and 2Cardiopulmonary Research, Institute
for Medical Research at North Shore-LIJ Health
System, Manhasset, NY.
PRO-OXIDANT IMPACT OF DIESEL ENGINE
EMISSIONS ACCORDING TO FUEL AND
AFTER-TREATMENT STRATEGIES:
IN VITRO AND IN VIVO BIOLOGICAL
EVIDENCES FOR NEW POTENTIAL
HEALTH CONCERNS. J. MORIN1, D. Preterre1,
M. Isabelle1, A. Bion1, 2, M. Fall1 and F. Dionnet2.
1
U644, INSERM, ROUEN, France and 2CERTAM,
Saint Etienne du Rouvray, France. Sponsor: R.
Forster.
Tuesday, March 7
1:30 PM to 4:30 PM
Room 5A
PLATFORM SESSION: PARTICULATE MATTER: EFFECTS AND
MECHANISMS
Chairperson(s): JeanClare Seagrave, Lovelace Respiratory Research
Institute, Albuquerque, NM and Ian Gilmour, U.S. EPA, Research Triangle
Park, NC.
PARAQUAT STIMULATES CYANIDEINSENSITIVE RESPIRATION AND NADPH
OXIDASE ACTIVITY IN MURINE LUNG
EPITHELIAL CELLS. J. P. Gray1, V. M. Mishin1,
P. J. Smith2, M. Thiruchelvam3, D. A. Cory-Slechta3,
D. E. Heck1 and J. D. Laskin3. 1Pharmacology and
Toxicology, Rutgers University, Piscataway, NJ,
2
Biocurrents Research Center, Marine Biological
Laboratory, Woods Hole, MA and 3Environmental
& Occupational Medicine, UMDNJ-RWJMS,
Piscataway, NJ.
OXIDATION OF NAD(P)H BY
HYPOCHLOROUS ACID AND
PEROXYNITRITE (± CO2): A COMPARATIVE
STUDY. R. M. Uppu, V. Rangan, C. R. Sparrow and
T. E. Perumal. Environmental Toxicology and Health
Research Center, Southern University and A&M
College, Baton Rouge, LA.
155
#1193
1:30
BIOLOGICAL RESPONSES TO
PARTICULATE MATTER IN COMPROMISED
RATS: THE ROLE OF TRANSITION
METAL AND POLYCYCLIC AROMATIC
HYDROCARBON CONTENTS. M. GerlofsNijland1, J. Boere1, D. Leseman1, R. Salonen2, M.
Sillanpaa4, R. Duffin3, 5, R. Schins3, P. Borm3 and F.
Cassee1. 1National Institute for Public Health and
the Environment, Bilthoven, Netherlands, 2National
Public Health Institute, Kuopio, Finland, 3Insitut
fur Umweltmedizinische Forschung, Dusseldorf,
Germany, 4Finnish Meteorological Institute,
Helsinki, Finland and 5University of Edinburgh,
Scotland, United Kingdom.
#1194
1:50
COMPARISON OF CARDIOPULMONARY
RESPONSES OF WISTAR KYOTO (WKY)
AND STROKE PRONE SPONTANEOUSLY
HYPERTENSIVE RATS (SHRSP) TO
PARTICULATE MATTER (PM) EXPOSURE.
J. G. Wallenborn1, M. C. Schladweiler2, A. D.
Ledbetter2, A. Nyska3, J. Johnson3, R. F. Thomas2,
R. Jaskot2, J. H. Richards2 and Universtiy of.
P. Kodavanti2. 1Environmental Sciences and
Engineering, University of North Carolina at Chapel
Hill, Chapel Hill, NC, 2NHEERL/ETD, U.S. EPA,
Research Triangle Park, NC and 3NIEHS, Research
Triangle Park, NC.
TUESDAY
#1184
45th Annual
Meeting & ToxExpo
#1195
#1196
#1197
#1198
2:10
2:30
2:50
3:10
A NEW APPROACH IN HEART RATE
VARIABILITY (HRV) ANALYSIS TO ASSESS
THE RISK OF HEART FAILURE IN MICE
EXPOSED TO AIRBORNE PARTICULATE
MATTER (PM). Q. LI1, J. Hwang2, M. Lippmann1
and L. Chen1. 1Nelson Institute of Environmental
Medicine, Tuxedo Park, NY and 2Statistics Institute,
Academia Sinica, Taipei, Taiwan.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
ANGIOTENSIN II POTENTIATE
CONCENTRATED AMBIENT PARTICULATE
MATTER (CAPS) INDUCED HYPERTENSION
AND VASCULAR DYSFUNCTION IN RATS.
C. Quan1, Q. Sun2, X. Jin1, Q. Li1, M. Zhong1,
S. Rajagopalan2 and L. Chen1. 1Environmental
Medicine, New York University, Tuxedo Park, NY
and 2Mount Sinai School of Medicine, New York.
POSTER SESSION: PESTICIDES
Chairperson(s): Marion Ehrich, VA MD Regional College of Vet. Med.,
Blacksburg, VA and Derek Gammon, CA EPA, Sacramento, CA.
AMBIENT PARTICULATE MATTER
EXPOSURE ACCELERATES
ATHEROSCLEROSIS AND VASCULAR
INFLAMMATION. L. Chen1, Q. Sun2, A. Wang2,
X. Jin1, M. Zhong1, Q. Li1, R. Kirk2, A. Schecter2, M.
Lippmann1 and S. Rajagopalan2. 1Env Med., NYU
SOM, Tuxedo, NY and 2Wiener Cardiovascular
Institute, Mt Sinai SOM, NY, NY.
IN VIVO TOXIC POTENCY OF AMBIENT
COARSE AND FINE PARTICULATE MATTER
SAMPLED ACROSS EUROPE. F. Cassee1,
M. Gerlofs-Nijland1, D. Leseman1, J. Boere1, I.
Mudway2, K. Donaldson5, C. Guastadisegni6, H.
Bloemen1, N. Janssen4, 1, T. Sandstrom3 and L. van
Bree1. 1National Institute for Public Health and
the Environment, Bilthoven, Netherlands, 2King’s
College London, London, United Kingdom,
3
University Hospital Umea, Umea, Sweden,
4
Institute for Risk Assessment Sciences, Utrecht,
Netherlands, 5University of Edinburgh, Edinburgh,
United Kingdom and 6Instituto Superiore di Sanita,
Rome, Italy.
3:30
EFFECTS OF AMBIENT PM ON CYTOKINE
PRODUCTION IN MOUSE MACROPHAGES
AND EPITHELIAL CELLS. R. Boyles1, I.
Gilmour3 and I. Jaspers2, 1. 1Environmental Science
and Engineering, University of North Carolina at
Chapel Hill, Chapel Hill, NC, 2Pediatrics, University
of North Carolina at Chapel Hill, Chapel Hill, NC
and 3U.S. EPA, Research Triangle Park, NC.
#1200
3:50
EFFECTS OF DIESEL EXHAUST ON TLR3
EXPRESSION AND SIGNALING IN MICE.
J. M. Ciencewicki1, K. Gowdy2, I. Gilmour3, 1, 2 and
I. Jaspers1. 1Curriculum of Toxicology, University
of North Carolina, Chapel Hill, NC, 2Immunology,
North Carolina State University, Raleigh, NC and
3
NHEERL, Environmental Protection Agency,
#1201
4:10
DIFFERENTIATED PRIMARY HUMAN
LUNG EPITHELIAL CELLS EXPOSED TO
DIESEL EXHAUST (DE) AT AN AIR-LIQUID
INTERFACE. J. Seagrave1, J. D. McDonald1,
S. Dunaway1, P. Hayden2, C. Stidley3 and J. L.
Mauderly1. 1Lovelace Respiratory Research Institute,
Albuquerque, NM, 2MatTek Corp., Ashland, MA
and 3Universtiy of. New Mexico, Albuquerque, NM.
TUESDAY
#1199
156
#1202
SPECIES DIFFERENCES IN THE
METABOLISM OF PYRETHROID
PESTICIDES IN RAT AND HUMAN LIVER
MICROSOMES. S. J. Godin1, M. F. Hughes2,
M. J. DeVito2 and M. K. Ross3. 1Curriculum in
Toxicology, University of North Carolina, Chapel
Hill, NC, 2NHEERL, U.S. EPA, Research Triangle
Park, NC and 3CEHS, Mississippi State University,
#1203
CUMULATIVE RISK OF PYRETHROIDS:
TESTING ADDITIVTY OF THE ACUTE
MOTOR EFFECTS OF ELEVEN
PYRETHROIDS. M. J. Wolansky2, C. Gennings3
and K. M. Crofton1. 1U.S. EPA, Research Triangle
Park, NC, 2National Research Council, Research
Triangle Park, NC and 3Department of Biostatistics,
VCU, Richmond, VA.
#1204
INHIBITION OF CYTOCHROME P450
2B1 BY THE CONAZOLE PESTICIDES
MYCLOBUTANIL AND TRIADIMEFON.
J. P. Stanko1 and H. A. Barton2. 1Curriculum in
Toxicology, University of North Carolina at Chapel
Hill, Chapel Hill, NC and 2National Center for
Computational Toxicology Environmental Protection
Agency, Research Triangle Park, NC.
#1205
ASSESSMENT AND EXAMINATION OF
MITOCHONDRIAL DNA SEQUENCE
CHANGES IN PRIMARY HUMAN
HEPATOCYTES FOLLOWING IN VITRO
EXPOSURE TO FOUR DIFFERENT
CONAZOLES. J. Jakupciak1, B. Roop2 and
S. Hester2. 1National Institute of Standards and
Technologies, Gaithersburg, MD and 2U.S. EPA,
Durham, NC. Sponsor: M. DeVito.
#1206
ALTERATIONS IN mRNA GENE
EXPRESSION ASSOCIATED WITH
CHOLESTEROL METABOLISM, CELL
CYCLE, AND OXIDATIVE STRESS INDUCED
BY TRIAZOLE CONTAINING CONAZOLES
IN RAT LIVER. S. Nesnow, B. Roop, S. Thai, D.
C. Wolf, C. Jones, G. Nelson and S. Hester. U.S.
EPA, Durham, NC.
#1207
UTILIZING HUMAN CYTOCHROME P450
SPECIFIC CONTENT AND ACTIVITY
TO BETTER MODEL PARATHION AND
CHLORPYRIFOS METABOLISM IN
INFANTS, CHILDREN, AND ADULTS. R. J.
Foxenberg, J. B. Knaak, B. P. McGarrigle, P. J.
Kostyniak and J. R. Olson. Pharmacology and
Toxicology, SUNY at Buffalo, Buffalo, NY.
45th Annual
Meeting & ToxExpo
#1208
IN VITRO METABOLISM OF TRIADIMEFON
BY RAT LIVER MICROSOMES. Y. M. sey. U.S.
#1209
FIPRONIL INDUCES CYP3A4 CYP2B6
AND CYP1A1 GENE EXPRESSION AND
APOPTOSIS IN HUMAN HEPATOCYTES. P. C.
Das1, N. Cherrington2, Y. Cao1, E. Hodgson1 and R.
L. Rose1. 1Environmental & Molecular Toxicology,
North Carolina State University, Raleigh, North
Carolina, NC and 2College of Pharmacy, University
of Arizona, Tucson, AZ.
#1210
THE USE OF ZEBRAFISH TO ELUCIDATE
THE MECHANISM OF DITHIOCARBAMATE
DEVELOPMENTAL TOXICITY. F. Tilton,
J. K. La Du, N. Alzarban and R. L. Tanguay.
Environmental and Molecular Toxicology, MFBSC,
EHSC, Oregon State University, Corvallis, OR.
#1211
CHLORPYRIFOS AND ITS METABOLITES
INDUCE APOPTOSIS IN PLACENTAL
CHORIOCARCINOMA CELLS. M. D.
Saulsbury, S. O. Heyliger, D. Round, Q. Chen, K.
Wang, J. Morse and D. J. Johnson. Pharmaceutical
Sciences, Hampton University, Hampton, VA.
#1212
DEVELOPMENTAL EXPOSURE TO
ENVIRONMENTALLY RELEVANT
CONCENTRATIONS OF DIELDRIN IN BABL/
C MICE DOES NOT AFFECT MAMMARY
GLAND DEVELOPMENT. W. G. Foster, P.
Mirshokraei, S. Bulk and A. C. Holloway. OBS/
GYN, McMaster University, Hamilton, ON, Canada.
#1213
BEHAVIOR OF FENTHION AFTER
CHLORINATION TREATMENT AND EFFECT
OF ITS PRODUCTS ON CHOLINESTERASE
ACTIVITY. T. Nishimura1, M. Tahara1, R. Kubota1,
K. Shimizu1, M. Ema2 and H. Tokunaga1. 1Division
of Environmental Chemistry, National Institute of
Health Sciences, Tokyo, Japan and 2Division of Risk
Assessment, Biological Safety Research Center,
#1214
REACTIVE OXYGEN SPECIES
INVOLVEMENT IN THE PESTICIDESINDUCED CYTOTOXICITY IN NEURONAL
CELLS (SH-SY5Y), IN VITRO. Z. Jia1 and H.
Misra1, 2. 1Department of Biomedical Sciences
and Pathobiology, Virginia Tech, Blacksburg, VA
and 2Edward via Virginia College of Osteopathic
Medicine, Blacksburg, VA.
#1215
THE USE OF THE INHIBITORY RATE
CONSTANT KI TO CHARACTERIZE
INHIBITION OF ACETYLCHOLINESTERASE
BY ORGANOPHOSPHATES. C. Rosenfeld1 and
L. G. Sultatos2. 1Schering-Plough Research Institute,
Lafayette, NJ and 2Pharmacology & Physiology,
UMD New Jersey Medical School, Newark, NJ.
157
#1216
METHOXYCHLOR-INDUCED INDUCIBLE
NITRIC OXIDE SYNTHASE AND
PROINFLAMMATORY CYTOKINES
EXPRESSION IN MACROPHAGES : MAPKS
AND NF-κB AS POTENTIAL MOLECULAR
TARGETS. J. Kim1, 2, K. Oh1, 2, E. Han1, 2, H. Kim2,
Y. Hwang1, 2, D. Kim3 and H. Jeong1, 2. 1Pharmacy,
Chosun University, Kwangju, South Korea,
2
University, Kwangju, South Korea and 3Pathology,
College of Oriental Medicine, Daejeon University,
Daejeon, South Korea.
#1217
IDENTIFICATION OF A NOVEL
HEMOGLOBIN ADDUCT IN SPRAGUEDAWLEY RATS EXPOSED TO ATRAZINE.
G. Dooley1, J. Prenni2, B. Cranmer1, P. Prentiss1,
M. Andersen3 and J. Tessari1. 1Environmental and
Radiological Health Sciences, Colorado State
University, Fort Collins, CO., 2Macromolecular
Resources, Colorado State University, Fort Collins,
CO and 3Chemical Industrial Institute of Toxicology,
#1218
UP-REGULATION OF CYCLOOXYGENASE2 GENE EXPRESSION BY ALPHA- AND
BETA-ENDOSULFAN IN MACROPHAGES.
K. N. Oh1, 2, J. Y. Kim1 and H. Jeong1, 2. 1Pharmacy,
2
#1219
USE OF EXPOSURE RELATED DOSE
ESTIMATING MODEL (ERDEM) TO
CONSTRUCT A PBPK/PD MODEL FOR
CARBOFURAN WITH THE REPORTED
EXPERIMENTAL DATA IN THE RAT. X.
Zhang1, M. S. Okino2, F. W. Power2, J. B. Knaak3, A.
M. Tsang1, L. S. Harrison1, C. B. Thompson1 and
C. C. Dary2. 1Anteon Corporation, Las Vegas, NV,
2
NERL, U.S. EPA, Las Vegas, NV and 3Department
of Pharmacology and Toxicology, SUNYAB,
Buffalo, NY.
#1220
THE ROLE OF 4-METHYLPYRAZOLE AS
THE ANTIDOTE FOR 2-CHLOROETHANOL
INTOXICATION. D. Hung, Y. Chen and C. Hsu.
Emergency Toxicology, Taichung Veterans General
Hospital, Taichung, Taiwan. Sponsor: S. Lin-Shiau.
TUESDAY
45th Annual
Meeting & ToxExpo
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
#1225
EFFECT OF ALCOHOL ON OXIDATIVE
STRESS AND DNA DAMAGE IN MOUSE
LIVER EXPRESSING HEPATITIS C VIRAL
CORE PROTEIN. C. L. Powell1, 2, O. Kosyk2,
L. A. Showalter3, S. A. Weinman3 and I. Rusyn1,
2 1
. Curriculum in Toxicology, University of
North Carolina at Chapel Hill, Chapel Hill,
NC, 2Department Environmental Sciences &
Hill, Chapel Hill, NC and 3Center for Hepatitis
Research, University of Texas Medical Branch,
Galveston, TX.
#1226
PHENOBARBITAL INDUCES UNIQUE TIME
DEPENDENT PATTERNS OF GC-RICH AND
GENE-SPECIFIC ALTERED METHYLATION
IN THE LIVER OF TUMOR-PRONE B6C3F1
(B6) MICE. J. I. Goodman and A. N. Bachman.
Pharmacology and Toxicology, Michigan State
#1227
MECHANISM OF AFLATOXIN B1-INDUCED
HEPATIC TUMOR PROMOTION BY THE
DIETARY PHYTOCHEMICAL 3, 3, ’DIINDOLYLMETHANE: A TOXICOGENOMIC
APPROACH. S. C. Tilton1, 2, J. D. Hendricks1, C.
B. Pereira3, G. S. Bailey1, 2 and D. E. Williams1, 2.
1
Environmental and Molecular Toxicology, Oregon
State University, Corvallis, OR, 2Linus Pauling
Institute, Oregon State University, Corvallis, OR and
3
Department of Statistics, Oregon State University,
Corvallis, OR.
#1228
DOSE-DEPENDENCE OF PROMOTION
OF 2-AMINO-3, 8-DIMETHYLIMIDAZO[4,
5-F]QUINOXALINE -INDUCED RAT
HEPATOCARCINOGENESIS BY ETHANOL;
EVIDENCE FOR A THRESHOLD. M. Kushida1,
2
, H. Wanibuchi2, A. Kinoshita2, J. Kang2, R.
Puatanachokchai2, M. Wei2, T. Sukata1, 2, S.
Uwagawa1, 2 and S. Fukushima2. 1Environmental
Health Science Laboratory, Sumitomo Chemical
Co., Ltd., Osaka, Japan and 2Department of
Pathology, Osaka City University Medical School,
Osaka, Japan.
#1229
COMPARISON OF GENE EXPRESSION
PROFILES FROM MICE FED THREE
TOXICOLOGICALLY DIFFERENT
TRIAZOLE-BASED CONAZOLES. W. Ward,
S. Hester, S. Thai, B. Roop, J. Allen, C. Jones, D.
Wolf, S. Nesnow and D. Delker. Environmental
Carcinogenesis Division, U.S. EPA, Research
Triangle Park, NC.
#1230
INDUCTION OF GLUTATHIONE STRANSFERASE IN IGF TYPE I RECEPTOR
OVEREXPRESSED HEPATOMA CELLS. K.
Kang1, J. Lee1 and S. Kim2. 1College of Pharmacy,
Chosun University, Gwangju, South Korea and
2
College of Pharmacy, Seoul National University,
Seoul, South Korea.
POSTER SESSION: HEPATOCARCINOGENESIS
Chairperson(s): Ammie Bachman, Michigan State University, East
Lansing, MI.
#1221
#1222
#1223
TUESDAY
#1224
EFFECT OF THE DELETION OF
THE P50 SUBUNIT OF NF-κB ON
HEPATOCARCINOGENESIS IN MICE
RECEIVING DIETHYLNITROSAMINE AND
POLYCHLORINATED BIPHENYLS. J. C.
Tharappel1, B. T. Spear1, H. Lehmler3, E. Y. Lee4, L.
W. Robertson4 and H. P. Glauert1. 1Graduate Center
for Nutritional Sciences, University of Kentucky,
Lexington, KY, 2Microbiology/Immunology and
Molecular Genetics, University of Kentucky,
Lexington, KY, 3Department of Occupational and
Environmental Health, University of Iowa, Iowa
City, IA and 4Pathology and Laboratory Medicine,
University of Kentucky, Lexington, KY.
MOLECULAR MECHANISMS ASSOCIATED
WITH ABERRANT LIVER GROWTH AND
CARCINOGENESIS IN F344 RATS TREATED
WITH NONGENOTOXIC CARCINOGENS. R.
Currie, J. Dow, R. Lee, L. Cottrell, C. Sadler, F. Lim,
A. Hargreaves, J. Wright, C. Waterfield, J. Ashby, I.
Kimber, G. Orphanides and J. G. Moggs. Syngenta
CTL, Macclesfield, Cheshire, United Kingdom.
IMMUNOHISTOCHEMICAL
CHARACTERIZATION OF PRENEOPLASTIC LESIONS OBSERVED
IN A LONG-TERM CLOFIBRIC
ACID-INDUCED NON-GENOTOXIC
HEPATOCARCINOGENESIS STUDY IN THE
RAT. C. Michel1, C. Desdouets2, K. R. Isaacs3, R. R.
Roberts4 and E. Boitier1. 1Drug Safety Evaluation,
sanofi aventis, Vitry-sur-Seine, France, 2INSERM
U370, Paris, France, 3CITP, Harrogate, United
Kingdom and 4Safety Assessment, AstraZeneca,
Cheshire, United Kingdom.
ORPHAN NUCLEAR RECEPTOR
CONSTITUTIVE ACTIVE/ANDROSTANE
RECEPTOR (CAR)-MEDIATED
ALTERATIONS IN DNA METHYLATION
DURING PHENOBARBITAL (PB)
PROMOTION OF LIVER TUMORIGENESIS.
J. M. Phillips1, Y. Yamamoto2, M. Negishi2, R.
R. Maronpot3 and J. I. Goodman4. 1Biochem.
& Mol. Biol., Mich. State Universtiy of., East
Lansing, MI, 2Reproductive and Developmental
Toxicology, NIEHS, NIH, Research Triangle
Park, NC, 3Experimental Pathology, NIEHS, NIH,
Research Triangle Park, NC and 4Pharmacology
and Toxicology, Mich. State Universtiy of., East
Lansing, MI.
158
45th Annual
Meeting & ToxExpo
#1231
COMPARATIVE LIVER EFFECTS OF
CYPROCONAZOLE AND PHENOBARBITAL
IN THREE STRAINS OF MICE. R. C. Peffer1, T.
Pastoor1, G. Millburn2, J. Wright2, H. Eyton-Jones2,
J. Harris2, J. Kilgour2, F. Waechter3 and J. Moggs2.
1
Global Human Safety, Syngenta Crop Protection,
Inc., Greensboro, NC, 2Central Toxicology
Laboratory, Syngenta Ltd., Macclesfield, United
Kingdom and 3Syngenta AG, Basel, Switzerland.
#1237
ATRAZINE DISPOSITION IN PREGNANT
AND LACTATING LONG-EVANS RATS. J. L.
Rayner1, 3, E. P. Hines3, R. Barbee3, J. V. Nguyen2,
P. Panuwet2, D. B. Barr2, R. D. Whitehead2 and S.
E. Fenton3. 1DESE, UNC-Chapel Hill, Chapel Hill,
NC, 2Division Laboratory Sciences, NCEH, CDC,
Atlanta, GA and 3RTD, NHEERL, ORD, U.S. EPA,
#1238
GENE EXPRESSION PROFILING SUGGESTS
A CONSERVED INITIAL MECHANISM
FOR FETAL AND PUBERTAL PHTHALATE
TESTICULAR INJURY. K. Johnson, D. Wallace
and S. Lahousse. CIIT Centers for Health Research,
Research Triangle Park, NC. Sponsor: K. Gaido.
#1239
AN INHALATION F1 GENERATION
REPRODUCTIVE TOXICITY STUDY OF OCT
AMETHYLCYCLOTETRASILOXANE (D4) IN
FEMALE RATS. W. H. SIDDIQUI1, D. G. Stump2,
J. F. Holson2, D. T. Kirkpatrick2 and K. P. Plotzke1.
1
Health and Environmental Sciences, Dow Corning
Corporation, Midland, MI and 2Developmental
and Reproductive Toxicology, WIL Research
Laboratories, LLC, Ashland, OH.
#1240
28-DAY GAVAGE AND REPRODUCTIVE/
DEVELOPMENTAL SCREENING TOXICITY
STUDIES OF DODECAMETHYLCYCLOHE
XASILOXANE (D6) IN SPRAGUE-DAWLEY
RATS. B. Carlton1, W. H. SIDDIQUI2, L. Meeker2,
J. Crissman2, J. Knochel2, S. Crofoot2 and K.
Plotzke2. 1Toxicology, Rhodia Inc., Raleigh, NC and
2
Corporation, Midland, MI.
#1241
THE REPRODUCTIVE TOXICITY OF
SODIUM TUNGSTATE IN THE SPRAGUEDAWLEY RAT. E. W. Johnson, H. J. Boeckman,
D. P. Arfsten, B. L. Steele, M. J. Thompson, K. W.
Reilly, S. L. Prues, M. R. Varney, J. R. Cunningham,
A. M. Lear, M. Giesige, D. Thompson, T. L.
Naylor and E. R. Wilfong. Naval Health Research
Center Detachment Environmental Health Effects
Laboratory, Wright-Patterson AFB, OH.
#1242
TWO-GENERATION STUDY OF DIETARY
17β-ESTRADIOL (E2) IN CD-1® SWISS MICE.
R. W. Tyl1, C. B. Myers1, M. C. Marr1, C. S. Sloan1,
N. P. Castillo1, M. M. Veselica1, J. C. Seely2, S. S.
Dimond3, J. P. Van Miller4, G. D. Stropp5 and J. M.
Waechter6. 1RTI International, Research Triangle
Park, NC, 2EPL, Inc., Research Triangle Park, NC,
3
GE Advanced Materials, Plastics, Pittsfield, MA,
4
Toxicology/Regulatory Services, Charlottesville,
VA, 5Bayer HealthCare AG, Wuppertal, Germany
and 6Dow Chemical Co., Midland, MI.
#1243
SEX RATIO OF THE OFFSPRING OF
SPRAGUE-DAWLEY RATS EXPOSED TO
TCDD IN UTERO AND LACTATIONALLY IN
A THREE-GENERATION STUDY. J. Rowlands1,
R. A. Budinsky1, L. L. Aylward2 and E. W. Carney1.
1
The Dow Chemical Company, Midland, MI and
2
Exponent, Inc., Alexandria, VA.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: MULTIGENERATION REPRODUCTIVE
TOXICITY EVALUATIONS
Chairperson(s): Rochelle Tyl, RTI International, Research Triangle Park,
NC and Barbara Neal, The Weinberg Group, Washington, DC.
#1232
#1233
#1234
THE EFFECTS OF INHALED VAPORS OF
ACRYLONITRILE ON RAT REPRODUCTION
OVER TWO SUCCESSIVE GENERATIONS.
M. D. Nemec1, D. T. Kirkpatrick1, J. Sherman1, J.
Van Miller2 and D. E. Strother3. 1WIL Research
Laboratories, LLC, Ashland, OH, 2Toxicology/
Regulatory Services, Inc., Charlottesville, VA and
3
Innovene, Chicago, IL.
THE HERBICIDE LINURON REDUCES
FETAL TESTOSTERONE PRODUCTION
DURING BOTH IN UTERO AND IN VITRO
EXPOSURES. C. Lambright1, J. Furr1, K.
Howdeshell2, L. Gray1 and V. Wilson1. 1ORD/RTD,
U.S. EPA, Research Triangle Park, NC and 2U.S.
EPA, NCSU Cooperative Training Agreement,
Raleigh, NC.
A TWO-GENERATION
REPRODUCTION STUDY WITH
PERFLUOROBUTANESULFONATE IN RATS.
J. Butenhoff and P. Lieder. 3M Company, St. Paul,
MN.
#1235
ACRYLONITRILE: EVALUATION OF
REPRODUCTIVE AND DEVELOPMENTAL
TOXICITY. B. Neal1, D. E. Strother2, J. J. Collins3
and J. C. Lamb1. 1The Weinberg Group, Washington,
DC, 2Innovene, Chicago, IL and 3The Dow Chemical
#1236
A TWO-GENERATION REPRODUCTIVE
TOXICITY STUDY OF DAG
(DIACYLGLYCEROL) ADMINISTERED
ORALLY BY GAVAGE IN RATS. B. J. Varsho1, J.
F. Knapp1, M. D. Nemec1, D. G. Stump1, O. Morita2,
Y. Tamaki2 and H. Suzuki2. 1DART, WIL Research
Laboratories, LLC, Ashland, OH and 2Safety and
Environmental Research, Kao Corporation, Haga
Tochigi, Japan.
159
TUESDAY
45th Annual
Meeting & ToxExpo
#1244
TWO-GENERATION REPRODUCTIVE
TOXICITY STUDY OF RESORCINOL IN
RATS. F. Welsch1, M. D. Nemec2 and W. B.
Lawrence2. 1Orbitox, Santa Fe, NM and 2WIL
Research Laboratories, LLC, Ashland, OH.
#1245
MULTIGENERATIONAL REPRODUCTIVE
ASSESSMENT OF AZT/3TC ADMINISTERED
TO CD-1® MICE BY GAVAGE. B. Muir1, J.
Bishop2, L. Murphy1, S. Pepperl1 and G. Wolfe1.
1
Gene Logic, Gaithersburg, MD and 2NTP, NIEHS,
#1250
MEASUREMENT OF EXPOSURE TO
COMPLEX MIXTURES OF POLYCYCLIC
AROMATIC HYDROCARBONS IN HUMAN
POPULATIONS. R. A. Lingenfelter1, L. Cizmas1,
Z. S. Naufel1, C. Naspinski1, L. He1, G. Zhou1,
T. McDonald1, G. Denoux1, R. Autenrieth1, A.
Mekhtiev2, A. Islamzadeh3 and K. C. Donnelly1.
1
Texas A&M University, College Station, TX,
2
Institute of Physiology n.a. A.I. Karaev, Baku,
Azerbaijan and 3Sumgayit Centre for Environmental
Rehabilitation, Sumgayit, Azerbaijan.
#1251
ESTIMATION OF GENOTOXIC EXPOSURES
IN CHILDREN WITH NEURAL TUBE
DEFECTS IN SHANXI, CHINA. Z. S. Naufal1, R.
H. Finnell1, G. Zhou1, T. J. McDonald1, Z. Li2, Z. Li2,
L. Pei2 and K. C. Donnelly1. 1Texas A&M University,
College Station, TX and 2Institute of Reproductive
and Child Health, Beijing, China.
#1252
EXPOSURE AND GENOTOXIC EFFECTS IN
MASTIC ASPHALT WORKERS EXPOSED
TO FUMES AND AEROSOLS OF BITUMEN.
B. Marczynski1, M. Raulf-Heimsoth1, R. Preuss2,
M. Kappler1, H. Kaefferlein1, K. Schott3, B. Pesch1,
G. Zoubek3, J. Hahn4, T. Mensing1, J. Angerer2 and
T. Bruening1. 1BGFA, Ruhr University of Bochum,
Bochum, Germany, 2IPASUM, University of
Erlangen, Erlangen, Germany, 3Bau-BG, Muenchen/
Neuwied, Germany and 4BGIA, Sankt Augustin,
Germany.
#1253
HIGH BACKGROUND LEVELS OF URINARY
BENZENE METABOLITES FOUND IN
VOLUNTEER STUDY. S. H. Gaffney and D. J.
Paustenbach. ChemRisk, Inc., San Francisco, CA.
#1254
EVALUATION OF PCDD/F AND DIOXIN-LIKE
PCB SERUM CONCENTRATION DATA FROM
THE 2001-2002 NATIONAL HEALTH AND
NUTRITION EXAMINATION SURVEY IN
THE UNITED STATES. M. A. Harris1, L. Ferriby1,
J. Knutsen2, P. Nony3, K. Unice4, D. Paustenbach5
and P. Scott4. 1ChemRisk, Inc., Houston, TX,
2
ChemRisk, Boulder, CO., 3Center for Toxicology
and Environmental Health, Little Rock, AR,
4
ChemRisk, Pittsburgh, PA and 5ChemRisk, San
Francisco, CA.
#1255
URINARY ARSENIC, PORPHYRINS AND
MALONDIALDEHYDE IN A POPULATION
16 YEARS AFTER ARSENIC MITIGATION
PROGRAM IN XINJIANG, CHINA. J. C. Ng1, F.
F. Liu1, J. Wang1, R. Maddelena1 and M. R. Moore1,
2 1
. National Research Centre for Environmental
Toxicology, The University of Queensland, Brisbane,
QLD, Australia and 2Queensland Health Scientific
Services, Queensland Health, Brisbane, QLD,
Australia. Sponsor: M. Hughes.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: BIOMONITORING
Chairperson(s): Teresa Dodd-Butera, San Diego State University, San
Diego, CA and Cecelia Tan, CIIT Centers for Health Research, Research
Triangle Park, NC.
#1246
TOXICOLOGICAL ANALYSES OF
MISSISSIPPI COASTAL WATER AND
SEDIMENT SAMPLES FOLLOWING
HURRICANE KATRINA. K. Argote1, A.
Chaudhary1, J. Weston1, S. Khan2 and K. L. Willett1.
1
Pharmacology and Environmental Toxicology,
2
Natural Product Center, University of Mississippi,
University, MS.
TUESDAY
#1247
FACTORS AFFECTING ACCURACY
IN EXPOSURE ESTIMATIONS FROM
BISPHENOL A (BPA) BIOMONITORING
STUDIES. J. M. Waechter, Jr.1, D. A. Markham1,
D. Beyer2 and R. N. Shiotsuka3. 1Toxicology and
Environmental Research and Consulting, The
Dow Chemical Company, Midland, MI, 2Bayer
HealthCare AG, Wuppertal, Germany and 3Bayer
CropScience, Stilwell, KS.
#1248
BIOMONITORING IMPLICATIONS
OF CHLORPYRIFOS (CPF) BLOOD
PARTITIONING DURING GESTATION
AND LACTATION. M. S. Marty1, D. L. Rick1,
J. M. Grundy1, M. J. Bartels1 and J. L. Mattsson2.
1
Toxicology & Environmental Research, The
Dow Chemical Company, Midland, MI and 2Dow
AgroSciences LLC, Indianapolis, IN.
#1249
PYRETHROID EXPOSURE IN THE INDOOR
ENVIRONMENT FOLLOWING USE OF
CYPERMETHRIN FOGGERS. J. J. Keenan1, R.
S. Gold2, G. Leng3, X. Zhang1 and R. I. Krieger1.
1
Entomology, University of California, Riverside,
CA, 2Brigham Young University-Hawaii, Laie, HI
and 3Bayer Industry Services, Leverkusen, Germany.
160
45th Annual
Meeting & ToxExpo
#1256
RELATION OF URINARY METABOLITES
OF INORGANIC ARSENIC WITH
TRANSFORMING GROWTH FACTOR
ALPHA CONCENTRATION IN BLADDER
UROTHELIAL CELLS FROM A POPULATION
ENVIRONMENTALLY EXPOSED TO
INORGANIC ARSENIC. O. L. Valenzuela1, D. R.
Germolec2, E. A. Garcia-Montalvo1, L. C. SanchezPena1, A. Hernandez-Zavala1, 3 and L. M. Del Razo1.
1
Toxicology, Cinvestav, Mexico D.F., Mexico,
2
NIEH, Research Triangle Park, NC and 3INSP,
Cuernavaca, Mexico.
#1257
BIOMARKERS OF AIR POLLUTION
EXPOSURE - STUDY IN POLICEMEN IN
PRAGUE. J. Topinka, B. Binkova, O. Sevastyanova,
I. Chvatalova, A. Milcova, Z. Lnenickova, Z.
Suchankova, I. Solansky and R. J. Sram. Genetic
Ecotoxicology, Institute of Experimental Medicine
AS CR, Prague 4, Czech Republic. Sponsor: H.
Autrup.
#1258
PATTERNS OF URINARY EXCRETION OF
ARSENIC METABOLITES IN A POPULATION
WITH LOW ARSENIC EXPOSURE. R. S.
Kaetzel1, M. R. Edwards1, Y. W. Lowney2 and J. S.
Tsuji1. 1Exponent, Bellevue, WA and 2Exponent,
Boulder, CO.
#1259
#1263
PREDICTING GC/MS TEQ FROM XDSCALUX® DETERMINATIONS OF DIOXIN
CONTAMINATION IN SOIL. G. C. Clark1, J.
Orelien2, J. D. Gordon1, A. C. Chu1, M. D. Chu3,
D. J. Brown4 and M. S. Denison5. 1Xenobiotic
Detection Systems, Inc., Durham, NC, 2SciMetrika,
LLC., Research Triangle Park, NC, 3Analytical
Perspectives, Wilmington, NC, 4Marietta College,
Marietta, OH and 5Department of Environmental
CA.
#1264
DNA-PROTEIN CROSSLINKS AS
A POTENTIAL BIOMONITOR OF
HEXAVALENT CHROMIUM EXPOSURE
IN RAINBOW TROUT. K. N. Mellinger1, J.
R. Kuykendall1, K. L. Miller1, A. V. Cain1, B. L.
Finley2 and D. J. Paustenbach2. 1Raabe College of
Pharmacy, Ohio Northern University, Ada, OH and
2
ChemRisk, San Francisco, CA.
#1265
COMPARISON OF NICKEL-INDUCED
DNA-PROTEIN CROSSLINKS IN SEVERAL
FRESHWATER FISH SPECIES AFTER ACUTE
EXPOSURE. A. V. Cain, K. N. Mellinger, K. L.
Miller, M. W. Mullen and J. R. Kuykendall. Raabe
College of Pharmacy, Ohio Northern University,
Ada, OH. Sponsor: B. Finley.
STUDYING THE CYTO-GENETIC EFFECTS
IN WORKERS OCCUPATIONALLY EXPOSED
TO VINCRISTINE WITH FOUR GENETIC
TESTS. H. Jiliang, D. Hongping, Z. Meibian, W.
Wei, J. Lifen, Z. Wei, L. Jianlin and W. Baohong.
Institute of Occupational and Environmental Health,
Medical College, Zhejiang University, Hangzhou,
Zhejiang, China.
#1266
PERSISTENCE OF DNA-PROTEIN CROSSLINKS IN ERYTHROCYTES OF CHANNEL
CATFISH AFTER ACUTE HEXAVALENT
CHROMIUM EXPOSURE. M. W. Perry1, J. R.
Kuykendall1, K. L. Miller1, K. N. Mellinger1, A. V.
Cain1, B. L. Finley2 and D. J. Paustenbach2. 1Raabe
College of Pharmacy, Ohio Northern University,
Ada, OH and 2ChemRisk, San Francisco, CA.
#1260
DIETHYL PHTHALATE: A
BIOMONITORING-BASED RISK
ASSESSMENT. S. W. Robison, W. J. Greggs, A.
E. Hochwalt, K. A. Kohrman, K. Kosemund, D.
A. McMillan and J. M. Naciff. Procter & Gamble,
Cincinnati, OH.
#1267
#1261
CONSERVATISM OF THE PESTICIDE
HANDLERS EXPOSURE DATABASE: A
COMPARISON WITH BIOMONITORING
DATA FOR SIMILAR WORK TASKS. J. H.
Ross1 and J. H. Driver2. 1infoscientific.com, Inc.,
Carmichael, CA and 2infoscientific.com, Inc.,
Manassas, VA.
DIETARY HEXAVALENT CHROMIUM
EXPOSURE CAUSES DNA-PROTEIN
CROSSLINK FORMATION IN
ERYTHROCYTES OF LARGEMOUTH BASS.
K. L. Miller, K. N. Mellinger, A. V. Cain and J. R.
Kuykendall. Raabe College of Pharmacy, Ohio
Northern University, Ada, OH. Sponsor: B. Finley.
#1262
PLACENTAL GLUTATHIONE-STRANSFERASE: ASSOCIATION OF
GENOTYPE, ACTIVITY AND MATERNAL
NUTRITION IN A MEXICAN OBSTETRIC
POPULATION. T. Dodd-Butera1, P. Quintana1,
M. Ramirez-Zetina2, M. Sierra1, C. Shaputnic1, S.
Hull1, S. Ingmanson1 and A. C. Batista3. 1Graduate
School of Public Health, SDSU, San Diego, CA,
2
Instituto Mexicano de Seguro Social, Tijuana,
Baja California, Mexico and 3Centros des Estudios
Xochicalco, Tijuana, Baja California, Mexico.
Sponsor: A. dePeyster.
161
TUESDAY
45th Annual
Meeting & ToxExpo
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
#1274
A PHYSIOLOGICALLY BASED
PHARMACOKINETIC MODEL OF
TRIHALOMETHANES IN THE PREGNANT
RAT: IDENTIFICATION OF KEY DATA
NEEDS. M. H. Lumpkin1, G. L. Diamond1, G.
L. Kedderis2, M. A. Odin1, J. R. White1, L. K.
Teuschler3, G. E. Rice3, J. B. Reid3 and J. C.
Lipscomb3. 1Environmental Science Center, Syracuse
Research Corporation, Syracuse, NY, 2Private
Consultant, Chapel Hill, NC and 3ORD, NCEA, U.S.
EPA, Cincinnati, OH.
#1275
CANCER DOSE-RESPONSE ANALYSIS FOR
2-CHLORO-1, 3-BUTADIENE: COMPARISON
OF RODENT AND HUMAN EXPOSURE
OUTCOMES USING PHYSIOLOGICALLY
BASED MODELING. M. W. Himmelstein, R.
C. Leonard and R. Valentine. DuPont Haskell
Laboratory for Health and Environmental Sciences,
Newark, DE.
#1276
USING DOSE METRICS TO BETTER
IDENTIFY RELEVANT EXPOSURES WHEN
ASSESSING IMPACTS FROM EXOGENOUS
CHEMICALS. J. N. Blancato1, F. W. Power2, M. V.
Evans1, M. S. Okino2 and C. C. Dary2. 1U.S. EPA,
Research Triangle Park, NC and 2U.S. EPA, LV, NV.
#1277
TRICHLOROETHYLENE CANCER
SLOPE FACTOR ESTIMATES USING A
HARMONIZED PBPK MODEL. E. Hack1, R.
Thompson2 and J. Zhao1. 1Toxicology Excellence
for Risk Assessment, Cincinnati, OH and 2Indiana
Department of Environmental Management,
Indianapolis, IN.
#1278
APPLICATION OF PBPK MODELING IN
SUPPORT OF THE RISK ASSESSMENT OF 1,
1, 1-TRICHLOROETHANE. J. E. Dennison, Y.
Lu, M. Lohitnavy and R. S. Yang. Quantitative and
Computational Toxicology Group, Environmental
& Radiological Health Sciences, Colorado State
University, Ft. Collins, CO.
POSTER SESSION: PHYSIOLOGICALLY-BASED MODELS:
APPLICATIONS
Chairperson(s): Teresa Leavens, CIIT, Research Triangle Park, NC and
Matthew Himmelstein, DuPont, Newark, DE.
#1268
#1269
#1270
THE EFFECT OF UNCERTAINTY FACTOR
PLACEMENT IN A PHYSIOLOGICALLYBASED PHARMACOKINETIC (PBPK)
MODEL OF TRICHLOROETHYLENE (TCE)
FOR ACUTE EXPOSURE GUIDELINE
LEVELS (AEGL). C. R. Eklund1, W. K. Boyes2,
J. E. Simmons1 and M. V. Evans1. 1Experimental
Toxicology Division, U.S. EPA, Research Triangle
Park, NC and 2Neurotoxicology Division, U.S. EPA,
DERIVATION OF REFERENCE
CONCENTRATION (RFC) FROM DOSERESPONSE (D-R) ANALYSIS FOR CHEMICAL
MIXTURES USING PHYSIOLOGICALLY
BASED TOXICOKINETIC (PBTK) MODEL. G.
Balagopal and D. Manca. Standards Development
Branch, Ontario Ministry of the Environment,
Toronto, ON, Canada.
USING A PBPK MODEL TO EXPLORE
MECHANISMS OF OBSERVED
PHARMOCOKINETIC DIFFERENCES OF
PHTHALATES ACROSS LIFE-STAGES IN
RATS. R. A. Clewell1, 2, J. Kremer2, M. Andersen2
and S. Borghoff2. 1Environmental Sciences and
Hill, Chapel Hill, NC and 2CIIT Centers for Health
RECONSTRUCTING HUMAN
TRIHALOMETHANES EXPOSURE
FROM BIOMONITORING DATA
WITH PHYSIOLOGICALLY BASED
PHARMACOKINETIC MODELS. A. M. Mason2,
H. J. Clewell1, K. H. Liao1 and Y. Tan1. 1Center for
Human Health Assessment, CIIT Centers for Health
Research, Research Triangle Park, NC and 2Chlorine
Chemistry Council, Arlington, VA.
#1279
USING HUMAN LIFE STAGE PBPK/PD
MODEL PREDICTIONS OF PERCHLORATEINDUCED IODIDE INHIBITION TO
INFORM RISK ASSESSMENT IN SENSITIVE
POPULATIONS. D. R. Mattie1, T. R. Sterner2, E.
A. Merrill3 and R. A. Clewell4. 1AFRL, WrightPatterson AFB, OH, 2HJF, Wright-Patterson AFB,
OH, 3Geo-Centers/Alion, Wright-Patterson AFB,
OH and 4CIIT-CHR, Research Triangle Park, NC.
#1272
ROUTE EXTRAPOLATION OF MTBE
PHARMACOKINETICS IN RATS. T. Leavens
and S. Borghoff. CIIT Centers for Health Research,
#1280
#1273
THE USE OF A PHYSIOLOGICALLYBASED MODELING APPROACH FOR
ASSESSING THE MECHANISMS OF P-TERTOCTYLPHENOL TOXICOKINETICS IN
THE RAT. S. Haddad1, T. Peyret1, G. Hamelin2, K.
Krishnan2 and R. Tardif2. 1TOXEN, Montréal, QC,
Canada and 2GRIS, Montréal, QC, Canada.
ISSUES IN USING MARKOV CHAIN MONTE
CARLO ANALYSIS TO CALIBRATE A PBPK
MODEL FOR USE IN RISK ASSESSMENT:
CASE STUDIES WITH DICHLOROMETHANE
AND PERCHLOROETHYLENE. T. R.
Covington1, P. Gentry1, C. B. Van Landingham1
and H. J. Clewell2. 1ENVIRON International
Corporation, Ruston, LA and 2CIIT Centers for
Health Research, Research Triangle Park, NC.
TUESDAY
#1271
162
45th Annual
Meeting & ToxExpo
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
#1288
SHORT-TERM EEG RECORDING IN
CONSCIOUS MONKEYS: COMPARISON
OF NEEDLE ELECTRODES TO SURFACE
ELECTRODES EMBEDDED IN A CAP. K.
Beard, M. Vezina and C. Copeman. Toxicology,
#1289
COMPARISON OF SHORT-TERM EEG
RECORDINGS IN CONSCIOUS DOGS AND
NON-HUMAN PRIMATES. K. Tenneson, M.
Vezina and C. Copeman. Toxicology, Charles River
Laboratories Preclinical Montréal, Senneville, QC,
Canada.
#1290
TWO EXPERIMENTAL SCREENING
MODELS OF RETINAL DEGENERATION IN
THE LONG EVANS RAT. M. Vezina, A. Patel and
C. Copeman. Toxicology, Charles River Laboratories
Preclinical Montréal, Senneville, QC, Canada.
#1291
MULTIPLE-ENDPOINT CYTOTOXICITY
AND GENOTOXICITY ASSAY IN MOUSE
L5178Y CELLS WITH LIMITED COMPOUND
REQUIREMENTS. L. Recio1, M. Kehl1, J.
Winters1, C. Baldetti1, E. Livanos1 and P. Richter2.
1
Genetic Toxicology, ILS, Research Triangle Park,
NC and 2Office on Smoking and Health, CDC,
Atlanta, GA.
#1292
INTRANASAL ADMINISTRATION
TECHNIQUES FOR RODENTS AND LARGE
ANIMALS. W. Lee, A. Viau and C. Banks.
#1293
METHOD FOR REPEATED
INTRAVESICULAR INSTILLATION OF
TEST ARTICLE IN TOXICOLOGY STUDIES.
W. Ruddock, S. Vachon and G. Washer. ITR
Laboratories Canada Inc., Baie d’Urfe, QC, Canada.
#1294
5-BROMO-2’-DEOXYURIDINE DELIVERY
METHOD INFLUENCES LABELING OF RAT
NASAL EPITHELIUM CELLS. M. F. Struve,
S. A. Bumgardner, E. A. Gross and D. C. Dorman.
Biological Sciences, CIIT Centers for Health
#1295
ASSESSMENT OF LIVER TOXICITY FOR
REGULATORY PURPOSES. J. Schulze2 and C.
Siegers1. 1Department of Experimental and Clinical
Pharmacology and Toxicology, Luebeck, Germany
and 2Office of the Dean, Frankfurt/Main, Germany.
#1296
TACRINE HEPATOTOXICITY IN RODENT
MODELS. D. Evans1, A. Dahly-Vernon1, N.
Cozzi1, S. Nye1, Y. Harrington1, J. O’Connor1,
A. Wittenburg1, S. Korb1, H. Vernon1, J. Baye1,
L. Lapczynski1, R. Roman1, 2 and H. Jacob1, 2.
1
PhysioGenix, Milwaukee, WI and 2Medical College
of Wisconsin, Milwaukee, WI.
POSTER SESSION: SAFETY ASSESSMENT—METHODS AND
MODELS
Chairperson(s): Dave McCormick, IIT Research Institute, Chicago, IL and
David C. Dorman, CIIT Centers for Health Research, Research Triangle
Park, NC.
#1281
THE INFLUENCE OF DISEASE ON THE
TOXICOLOGICAL RESPONSE: ‘DISEASE
MODEL TOXICOLOGY’ M. Foster, S. W. Ernst,
K. Hickling, G. J. Oliver and M. Graham. Global
Safety Assessment, AstraZeneca R&D Charnwood,
Charnwood, United Kingdom.
#1282
SAFETY STRATEGIES IN DRUG DISCOVERY
SUPPORT. S. W. Ernst, M. Graham, M. Foster, S. C.
Boyer and G. J. Oliver. Global Safety Assessment,
AstraZeneca R&D Moelndal, Moelndal, Sweden.
#1283
ASSESSMENT OF THE POTENTIAL HEALTH
RISK OF HUMAN PHARMACEUTICALS IN
THE ENVIRONMENT. S. P. Binks1, M. J. Olson2
and V. L. Cunningham3. 1Corporate Environment,
Health & Safety, GlaxoSmithKline, Ware,
Hertfordshire, United Kingdom, 2GlaxoSmithKline,
Research Triangle Park, NC and 3GlaxoSmithKline,
King of Prussia, PA.
#1284
#1285
FEASIBILITY OF A TIERED APPROACH TO
THE STANDARD 28-DAY TOXICITY STUDY
FOR PHARMACEUTICAL INTERMEDIATES.
B. K. Shipp1, D. W. Moore2 and C. S. Schwartz1.
1
Pfizer Global Environment, Health & Safety,
Occupational Toxicology & Hazard Assessment,
Pfizer Inc., New York and 2PGRD Global
Environment, Health & Safety, Pfizer Global
Research & Development, Pfizer Inc., New London,
CT.
THE USE OF PROTON AND CARBON13 NMR TO IDENTIFY AND QUANTIFY
COMPOUNDS FOR HIGH THROUGHPUT
TOXICITY SCREENING. S. Graves1, C. Smith2, J.
Caffmeyer1 and W. Black1. 1Battelle, Columbus, OH
and 2NIEHS, Research Triangle Park, NC.
#1286
CONTAMINATION OF CONTROL ANIMALS
DURING REGULATORY TOXICOLOGY
STUDIES: AVOIDANCE, ASSESSMENT AND
CONSEQUENCES. L. K. Earl and S. Crome.
Huntingdon Life Sciences, Huntingdon, United
Kingdom. Sponsor: C. Hardy.
#1287
CEREBROSPINAL FLUID
PHARMACOKINETIC: FLUOROSCOPYGUIDED INTRATHECAL CATHETERS
FOR REPEATED SAMPLING IN BEAGLE
DOGS. I. Dean1, S. Authier1, 2 and E. Troncy2.
1
LAB. Preclinical Research, Laval, QC, Canada
and 2School of Veterinary Medicine, University of
Montréal, St-Hyacinthe, QC, Canada.
163
TUESDAY
45th Annual
Meeting & ToxExpo
#1297
NORMAL PHYSIOLOGICAL AND
PATHOLOGICAL VALUES FOR THE
SINCLAIR MINIATURE SWINE. H. J. Peeper1,
J. Liu Ph.D1, L. Brown DVM, Ph.D1, B. MacPherson
Ph.D2, E. Lynch Ph.D2, J. Kil MD2 and G. F.
Bouchard DVM MS DACT1. 1Sinclair Research
Center, Auxvasse, MO and 2Sound Pharmaceuticals
Inc., Seattle, WA.
#1298
GENETICALLY DIVERSE RATS DETECT
CLOFIBRATE TOXICITY. J. O’Connor1, N.
Cozzi1, Y. Harrington1, S. Nye1, A. Dahly-Vernon1,
D. Evans1, A. Wittenburg1, S. Korb1, H. Vernon1, J.
Baye1, L. Lapczynski1, R. Roman1, 2 and H. Jacob1, 2.
1
PhysioGenix, Milwaukee, WI and 2Medical College
of Wisconsin, Milwaukee, WI.
#1299
OCCUPATIONAL HAZARD
DETERMINATION: MUTAGENICITY OF
ISOLATED INTERMEDIATES IN DRUG
SYNTHESES. M. J. Olson1, F. J. Guerriero2 and
C. W. Seaman3. 1Corporate Environment Health
and Safety (CEHS), GlaxoSmithKline, Research
Triangle Park, NC, 2CEHS, GlaxoSmithKline, King
of Prussia, PA and 3CEHS, GlaxoSmithKline, Ware,
Hertfordshire, United Kingdom.
TUESDAY
#1300
UTILITY OF TOXICOGENOMICS IN THE
ELUCIDATION OF THE HEPATOTOXIC
MECHANISM OF A DISCONTINUED DRUG
CANDIDATE. C. Thompson and A. Roberts. DSE,
Sanofi-Aventis Pharmaceuticals, Bridgewater, NJ.
#1301
VALIDATION OF A NEUROLOGICAL
ASSESSMENT PANEL, INCLUDING
THE MODIFIED IRWIN TEST AND THE
FUNCTIONAL OBSERVATIONAL BATTERY
(FOB) IN SPRAGUE-DAWLEY RATS. C. PetitTurcotte, S. Authier, S. Fournier, F. Chaurand, A.
Zerouala and I. Dean. LAB. Pre-Clinical Research
International Inc., Laval, QC, Canada.
#1302
VALIDATION OF METHOD FOR ASSESSING
LOCAL TOLERANCE OF INTRAVENOUSLY
ADMINISTERED PHARMACEUTICAL
AGENTS FOLLOWING FIVE DAILY ONE
HOUR INFUSIONS IN RABBITS. S. Goel,
C. Moore, E. Chacon and L. Carter. Covance
Laboratories Inc., Vienna, VA.
#1303
VALIDATION OF A SURGICALLY
CANNULATED MOUSE INTRAVENOUS
INFUSION MODEL. O. P. Green, D. Patten and A.
Camacho. Toxicology, Huntingdon Life Sciences,
#1304
#1305
VALIDATION OF THE MEASUREMENT
OF RESISTANCE AND COMPLIANCE IN
THE CONSCIOUS RAT. M. J. Stonerook, S. A.
Behringer and J. P. Smith. Safety Pharmacology,
Battelle, Columbus, OH. Sponsor: M. Hejtmancik.
A VALIDATION FOR RESPIRATORY
SAFETY PHARMACOLOGY ASSESSMENT
IN ANESTHETIZED RATS. J. Bassett, J.
Johnson, R. D. Jones and F. Lucas. Toxicology and
Pharmacology, Ricerca Biosciences, LLC, Concord,
OH.
164
#1306
VALIDATION OF AN AUTOMATED IN-VITRO
MICRONUCLEUS ASSAY IN CHO-K1 CELLS.
D. Diaz. Toxicology, Cerep, Redmond, WA.
#1307
DETECTION OF HBV, HCV AND HIV
NUCLEIC ACIDS IN TISSUE SAMPLES. B.
Anekella, L. Tran, J. Wu, Y. Zhang, S. Hickman,
D. Steen and M. Manak. SeraCare BioServices,
Gaithersburg, MD. Sponsor: S. Manetz.
#1308
USE OF THE VIVOMETRICS LIFESHIRTâ
FOR AMBULATORY RESPIRATORY DATA
COLLECTION IN THE DOG AND MONKEY.
S. Mason1, H. Penton1, K. Norton1, C. Banks1 and A.
Derchak2. 1Toxicology, Charles River Laboratories
Preclinical Montréal, Senneville, QC, Canada and
2
VivoMetrics, Ventura, CA.
#1309
A GRAPHICAL EVALUATION METHOD
OF HEMATOLOGICAL AND SERUM
BIOCHEMICAL PARAMETERS FOR NONSTATISTICIANS. T. Koga, A. Yoneyama, H.
Okatani, T. Yamada, S. Nagayama and R. Nagata.
SNBL, Kagoshima, Japan.
#1310
LONG TERM (9-MONTH) CONTINUOUS
INTRAVENOUS INFUSION IN THE BEAGLE
DOG. L. Armer, A. Patel, C. Bosse, T. Gillis, C.
Copeman and M. Vezina. Toxicology, Charles River
Canada.
#1311
SCREENING STUDIES WITH OILY
VEHICLES FOR ORAL DRUG DELIVERY IN
THE MARMOSET (CALLITHRIX JACCHUS)
AND THE CYNOMOLGUS (MACACA
FASCICULARIS) MONKEY. S. H. Korte1,
D. Eastman2, Universtiy of. Zuehlke1 and G. F.
Weinbauer1. 1Covance, Muenster, Germany and
2
Procter & Gamble Pharmaceuticals Inc., Cincinnati,
OH.
#1312
MOLECULAR DETERMINANTS FOR
DETECTION OF HUMAN EYE IRRITATION
FROM HOMOLOGOUS CHEMICAL VAPORS
IN ACUTE EXPOSURES. J. E. Cometto-Muniz1,
W. S. Cain1 and M. H. Abraham2. 1Chemosensory
Perception Laboratory, Department of Surgery
(Otolaryngology), University of California, San
Diego, La Jolla, CA and 2Department of Chemistry,
University College London, London, United
Kingdom.
#1313
HISTAMINE RESPONSES AND MAXIMUM
TOLERATED DOSE ENDPOINTS IN DOGS
USED ON TOXICITY STUDIES. A. Lucock and
D. Everett. Covance Laboratories Ltd., Harrogate,
United Kingdom.
#1314
METABONOMIC PROFILING CORRELATES
WITH PPAR-MEDIATED MUSCLE TOXICITY
BUT NOT PERIPHERAL EDEMA. W. W.
Collette1, K. Palacio1, A. Deese2, G. J. Stevens1 and
H. S. Younis1. 1Worldwide Safety Sciences, Pfizer
Inc., La Jolla, CA and 2Analytical Research and
Development, Pfizer Inc., La Jolla, CA.
45th Annual
Meeting & ToxExpo
#1316
CORRELATION AMONG
CLINICOPATHOLOGICAL PARAMETERS
FOR MYOCARDIAL DAMAGE IN RATS
TREATED WITH ISOPROTERENOL. M.
Kurata, Y. Sasayama, T. Iidaka, T. Fukushima, M.
Sakimura and N. Shirai. Worldwide Safety Sciences,
Pfizer Global Research & Development, Nagoya
Laboratories, Pfizer Inc., Aichi, Japan.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
CLINICAL PATHOLOGY VARIATIONS
BETWEEN TWO ORIGINS IN CYNOMOLGUS
MONKEYS. H. Okatani, T. Koga, K. Nakama, H.
Kadokura, T. Yamada, S. Nagayama, H. Tokado,
K. Fukuzaki, G. Kito and R. Nagata. Drug Safety
Resarch Laboratories, Shin Nippon Biomedical
Laboratories, Kagoshima, Japan.
#1317
EXTERNAL TELEMETRY INVESTIGATION
OF ECG PARAMETERS FOR GROUP
HOUSED NON-RODENT TOXICITY STUDIES.
G. Froget, A. Baleydier, A. Betat, P. Lainee and R.
Forster. CIT, Evreux, France.
#1318
COMPARATIVE ANALYSIS OF
CLINICAL PATHOLOGY DATA IN AGED
OVARIECTOMIZED/INTACT AND YOUNG
ADULT FEMALE CYNOMOLGUS MONKEYS
OF MAURITIAN ORIGIN. Universtiy of. Zuehlke
and G. F. Weinbauer. Covance Laboratories GmbH,
Muenster, Germany.
#1319
PREDICTIVE IN VITRO STEM CELL
HEMOTOXICOLOGY USING THE HALO
PLATFORM FOR EARLY DRUG SCREENING
AND ESTIMATING PRE-CLINICAL AND
CLINICAL TRIAL DOSING. I. N. Rich and K.
M. Hall. HemoGenix Inc., Colorado Springs, CO.
Sponsor: A. Vickers.
#1320
DETECTION OF INCREASED SENSITIVITY
TO MULTIPLE DOSING AND RESIDUAL
GROWTH POTENTIAL OF STEM CELLS
AFTER IN VITRO DRUG ADMINISTRATION
USING THE HALO PREDICTIVE
PLATFORM. I. N. Rich and K. M. Hall.
HemoGenix Inc., Colorado Springs, CO. Sponsor:
A. Vickers.
POSTER SESSION: NUCLEAR RECEPTORS
Chairperson(s): William Baldwin, University of Texas at El Paso, El Paso,
TX and Ruth Roberts, AstraZeneca UK, Macclesfield, United Kingdom.
165
#1321
ENHANCED ACETAMINOPHEN TOXICITY
BY ACTIVATION OF THE PREGNANE X
RECEPTOR. G. L. guo2, 1, J. S. Moffit3, C. J. Nicol1,
J. M. Ward4, L. A. Aleksunes3, S. A. Kliewer5, J.
E. Manauto3 and F. J. Gonzalez1. 11.
Laboratory of Metabolism, NCI, NIH, Bethesda,
MD, 2Pharmacology, Toxicology and Therapeutics,
KS, 32.
Department of Pharmaceutical Sciences,
University of Connecticut, Storrs, CT, 43.
Veterinary and Tumor Pathology Section, NCI,
Frederick, MD and 5Pharmacology, University of
Texas Southwestern Medical Center, Dallas, TX.
#1322
ROLE OF NF-κB IN REGULATION OF
PXR TRANSCRIPTIONAL ACTIVITY: A
MECHANISM FOR THE SUPPRESSION OF
PXR-MEDIATED CYTOCHROMES P450
EXPRESSION BY PROINFLAMMATORY
AGENTS. X. Gu1, T. Sheng2, S. Ke1, L. J.
Dangott3, P. E. Thomas4, M. A. Gallo4, W. Xie5 and
Y. Tian1. 1Department of Veterinary Physiology
and Pharmacology, Texas A&M University,
College Station, TX, 2The University of Texas
Medical Branch, Galveston, TX, 3Department of
Biochemistry & Biophysics, Texas A&M University,
College Station, TX, 4EOHSI, Rutgers University,
Piscataway, NJ and 5University of Pittsburgh,
Pittsburgh, PA.
#1323
HORMONAL CONTROL SUPPORTS
XENOBIOTIC RECEPTOR MEDIATED
INDUCTION OF UGT1A1 IN TRANSGENIC
MICE. S. CHEN, D. Beaton, K. SenekeoEffenberger and R. H. Tukey. Laboratory of
Environmental Toxicology, Departments of
Pharmacology and Chemistry & Biochemistry,
University of California, San Diego, La Jolla, CA.
#1324
LIGAND-DEPENDENT ACTIVATION OF
DAX-1 SILENCES ANDROGEN RECEPTORMEDIATED TRANSACTIVATION IN
PROSTATE CANCER CELLS. S. Papineni1,
S. Chintharlapalli2, E. Lalli3 and S. Safe1, 2,
4 1
. Department of Veterinary Physiology and
Pharmacology, Texas A&M University, College
STation, TX, 2Department of Biochemistry and
Biophysics, Texas A&M University, College
STation, TX, 3Institut de Pharmacologie Moleculaire
et Cellulaire, Texas A&M University, Sophia
Antipolis, Valbonne, France and 4Institute of
Biosciences and Technology, Texas A&M University
Health Science Center, Houston, TX.
TUESDAY
#1315
45th Annual
Meeting & ToxExpo
#1325
A MIXED PREGNANE X RECEPTOR AND
ESTROGEN RECEPTOR ALPHA AGONIST
ALTERED HEPATIC CHOLESTEROL
HOMEOSTASIS AND INCREASED
PLASMA HIGH DENSITY LIPOPROTEIN
APOLIPOPROTEIN A1 IN MICE. J. Lee and
L. R. Curtis. Department of Environmental and
Corvallis, OR.
#1326
THE NUCLEAR RECEPTOR CAR
REGULATES DIO1 AND ALTERS THYROID
HORMONE ACTIVITY IN REGENERATING
LIVER. E. Tien, M. Negishi, K. Matsui and R.
Moore. National Institute of Environmental Health
Sciences, Research Triangle Park, NC.
#1327
NONYLPHENOL IS A CONSTITUTIVE
ANDROSTANE RECEPTOR (CAR)
ACTIVATOR. L. M. Chapman1, J. P. Hernandez1,
X. C. Kretschmer1, W. Huang2, D. D. Moore2 and
W. S. Baldwin1. 1Biological Sciences, University
of Texas at El Paso, El Paso, TX and 2Molecular
and Cellular Biology, Baylor College of Medicine,
Houston, TX.
#1328
UNIQUE TRANSCRIPTION START SITES
FOR PXR.1 AND PXR.2 IN HUMAN LIVER.
L. M. Tompkins, B. A. Wasilak and A. D. Wallace.
Environmental and Molecular Toxicology, North
#1329
MECHANISM OF P38 MITOGEN-ACTIVATED
PROTEIN KINASE INVOLVED IN THE
CONSTITUTIVE ANDROSTANE RECEPTOR
SIGNALING PATHWAY. F. Zhang1 and L. You2.
1
CIIT, Research Triangle Park, NC and 2CIIT,
#1330
TUESDAY
#1331
REGULATION OF TRANSCRIPTIONAL
ACTIVITY OF HUMAN PREGNANE X
RECEPTOR BY PROTEIN ARGININE
METHYLTRANSFERASE(S). Y. Xie1, X. Gu1, S.
Ke1, W. Xie3, M. Bedford2 and Y. Tian1. 1VTPP, Texas
A&M University, College Station, TX, 2Department
of Carcinogenesis, The University of Texas M.D.
Anderson Cancer Center, Smithville, TX and
3
PXR-DEPENDENT INDUCTION OF CYP3A4
GENE EXPRESSION BY O, P’-DDT IN HEPG2
CELLS. I. M. Medina-Diaz1, G. Elizondo1, A.
Sierra-Santoyo1, M. Bermudez2 and B. CisnerosVega2. 1Toxicology Section, Cinvestav, Mexico,
DF, Mexico and 2Genetic and Molecular Biology
Department, Cinvestav, Mexico, DF, Mexico.
#1332
GLUCOCORTICOID REGULATION OF
PXR INFLUENCES CYP3A4 INDUCTION
BY DEHP. B. A. Wasilak and A. D. Wallace.
Environmental and Molecular Toxicology, North
#1333
ANALYSIS OF THE TRANSCRIPTIONAL
REGULATORY REGION OF THE HUMAN
PXR (NR1I2) GENE. R. Hasegawa, K. Kurose,
S. Ikeda, S. Koyano, M. Tohkin and J. Sawada.
Sponsor: M. Ema.
166
#1334
ACTIVATION OF NUCLEAR RECEPTORS
CAR AND NRF2 BY GARLIC AND GARLIC
CONSTITUENTS. C. fisher1, L. M. Augustine1, S.
Bejati1, J. Maher2, D. M. Nelson3, C. D. Klaassen2,
L. Lehman-McKeeman3 and N. J. Cherrington1.
1
Pharmacology/Toxicology, University of Arizona,
Tucson, AZ, 2Department of Pharmacology,
Toxicology and Therapeutics Center, University
of Kansas Medical Center, Kansas City, KS and
3
Department of Metabolism and Pharmacokinetics,
Bristol-Myers Squibb Company, Wallingford, CT.
#1335
RAPID ESTROGEN-INDUCED SERINE
PHOSPHORYLATION OF NRF-1 AND ITS
IMPLICATIONS IN THE GROWTH OF
BREAST CANCER CELLS. Y. Zou, Q. Felty and
D. Roy. Environmental & Occupational Health,
Florida International University, Miami, FL.
#1336
PROMOTER ANALYSIS OF ESTROGEN
RESPONSIVE GENES. D. Humes, J. Burt,
L. Burgoon and T. Zacharewski. Biochemistry
and Molecular Biology, Center for Integrative
Toxicology, and NFSTC, Michigan State University,
East Lansing, MI.
#1337
TIME DEPENDENT MICROARRAY
ANALYSIS OF 17β-ESTRADIOL ELICITED
CHANGES IN MOUSE HEPA-1C1C7 GENE
EXPRESSION. Y. Tan, C. J. Fong, L. D. Burgoon
and T. R. Zacharewski. Department of Biochemistry
and Molecular Biology, Center for Integrative
Toxicology, National Food Safety and Toxicology
Center, Michigan State University, East Lansing,
MI.
#1338
TAMOXIFEN-INDUCED CHANGES IN
HEPATIC GENE EXPRESSION: AGONIST
AND ANTAGONIST ACTIVITIES OF THIS
SELECTIVE ESTROGEN RECEPTOR
MODULATOR (SERM). A. D. Benninghoff
and D. E. Williams. Environmental and Molecular
Toxicology, Oregon State University, Corvallis, OR.
#1339
ESTROGEN RECEPTOR-INDEPENDENT
INHIBITION OF TUMOR NECROSIS
FACTOR-α GENE EXPRESSION BY
PHYTOESTROGEN EQUOL IS MEDIATED
BY BLOCKING NUCLEAR FACTOR-κB
ACTIVATION IN MOUSE MACROPHAGES. J.
Kang, Y. Yoon, M. Han, S. Han, S. Park and H. Kim.
Bioevaluation Center, Korea Research Institute of
Bioscience and Biotechnology, Taejon, South Korea.
#1340
TEMPORAL AND DOSE-RESPONSE
UTERINE GENE EXPRESSION ANALYSIS OF
TAMOXIFEN TREATED C57BL/6 MICE BY
CDNA MICROARRAY. C. J. Fong, L. D. Burgoon
and T. R. Zacharewski. Biochemistry and Molecular
Biology, Center for Integrative Toxicolocy, National
Food Safety and Toxicology Center, Michigan State
45th Annual
Meeting & ToxExpo
#1341
PUTATIVE ROLE OF THE STEROID AND
XENOBIOTIC RECEPTOR (SXR) IN THE
MECHANISM OF HLA-DRα INDUCTION BY
RIFAMPICIN. E. Fuentes-Mattei1, 3, L. Quattrochi2,
J. Barwick2, P. S. Guzelian2 and B. D. Jimenez1, 3.
1
Biochemistry, UPR Medical Sciences Campus,
San Juan, Puerto Rico, 2Gastroenterology/Medical
Toxicology, University of Colorado Health Sciences
Center, Denver, CO and 3Center for Environmental
And Toxicological Research, UPR Medical Sciences
Campus, San Juan, Puerto Rico.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
#1347
THE TRANSCRIPTION FACTOR NRF2
CONTROLS THE EXPRESSION OF HEME
OXYGENASE-1 AND PHASE II-RELATED
GENES IN CELLS EXPOSED TO AQUEOUS
EXTRACTS OF CIGARETTE SMOKE. A.
Hengstermann1, C. Knoerr-Wittmann1, S. Gebel1, J.
Alam2 and T. Mueller1. 1PHILIP MORRIS Research
Laboratories GmbH, Cologne, Germany and
2
Department of Molecular Genetics, Alton Ochsner
Clinic Foundation, New Orleans, LA. Sponsor: H.
Haussmann.
#1348
MOUSE EMBRYONIC FIBROBLASTS
FROM NRF2-DEFICIENT MICE DISPLAY
INCREASED OXIDATIVE DAMAGE
FOLLOWING EXPOSURE TO DIQUAT.
W. O. Osburn1, N. Wakabayashi1, T. Nilles2, V.
Misra1, S. Biswal1, M. A. Trush1 and T. W. Kensler1.
1
Environmental Health Sciences, Johns Hopkins
University Bloomberg School of Public Health,
Baltimore, MD and 2Molecular Microbiology and
Immunology, Johns Hopkins University Bloomberg
School of Public Health, Baltimore, MD.
#1349
INDUCTION OF RENAL HEME
OXYGENASE-1 (HO-1) VIA NF-E2-RELATED
FACTOR 2 (NRF2) IN A RAT AND MOUSE
MODEL OF HEPATIC ISCHEMIAREPERFUSION INJURY. Y. Tanaka, J. M.
Maher, C. Chen and C. D. Klaassen. Pharmacology,
KS.
#1350
REGULATION OF METALLOTHIONEINIII GENE EXPRESSION BY PHYSICAL
INTERACTION OF P53 WITH P300. H. G. Kim1,
2
and H. Jeong1, 2. 1Pharmacy, Chosun University,
Kwangju, South Korea and 2Research Center for
Proteineous Materials, Chosun University, Kwangju,
South Korea.
#1351
METALLOTHIONEIN-III UPREGULATES
HEME OXYGENASE-1 EXPRESSION VIA
ACTIVATION OF NF-E2-RELATED FACTOR
2 IN NEURO2A CELLS. Y. Hwang1 and H.
South Korea and 2Research Center for Proteineous
Materials, Chosun University, Kwangju, South
Korea.
#1352
REGULATION OF THE STEROIDOGENIC
ACUTE REGULATORY PROTEIN (STAR) BY
CYCLIC ADENOSINE MONOPHOSPHATE
(CAMP) AND TRANSFORMING GROWTH
FACTOR-BETA (TGF-β) IN LARGEMOUTH
BASS. M. S. Prucha1, R. J. Kocerha2 and N. D.
Denslow3. 1Pharmacology, University of Florida,
Gainesville, FL, 2Scripps Research Institute, West
Palm Beach, FL and 3Physiological Sciences,
#1353
THE IDENTIFICATION OF HSF1DEPENDENT GENE TRANSCRIPTION IN
RESPONSE TO PROTEOTOXIC STRESS. T.
Page1, L. Yang1, L. Pluta1, R. Wolfinger2 and R.
Thomas1. 1CIIT, Research Triangle Park, NC and
2
SAS Institute, Cary, NC.
POSTER SESSION: GENE REGULATION I
Chairperson(s): Rao Uppu, Southern University, Baton Rouge, LA and
Edward Puzas, University of Rochester School of Medicine, Rochester, NY.
#1342
ARNT1 HAS A ROLE IN THE INNATE
IMMUNE RESPONSE IN HUMAN
KERATINOCYTES. K. N. De Abrew1, A. L.
Gibson2 and B. Allen-Hoffmann1, 2. 1Molecular
and Environmental Toxicology Center, University
of Wisconsin, Madison, WI and 2Pathology and
Laboratory Medicine, University of Wisconsin,
Madison, WI.
#1343
BETA-TUBULIN INHIBITS THE HYPOXIA
INDUCIBLE FACTOR-1ALPHA SIGNALING
IN MCF7 CELLS. X. Wang, K. A. Jensen and W.
K. Chan. Thomas J. Long School of Pharmacy and
Health Sciences, University of the Pacific, Stockton,
CA.
#1344
MODULATION OF HYPOXIA-INDUCIBLE
FACTOR MEDIATED GENE EXPRESSIONS
BY FLAVONOIDS. A. Lulla, L. Muppana and S.
Park. St. John’s University, Queens, NY.
#1345
HYPOXIA-INDUCIBLE FACTOR-1ALPHA
ACTIVATION BY METALLOTHIONEIN
IN THE HUMAN ENDOTHELIAL-LIKE
ECV304 CELL LINE UNDER NORMOXIC
CONDITIONS. H. Kim1, 2 and H. Jeong1, 2.
1
Pharmacy, Chosun University, Kwangju, South
Korea and 2Research Center for Proteineous
Korea.
#1346
HNF4ALPHA DYSFUNCTION IN DRUGINDUCED LIVER TOXICITY. J. Borlak and
M. Niehof. Fraunhofer Institut of Toxicology and
167
TUESDAY
45th Annual
Meeting & ToxExpo
#1354
#1355
#1356
P53 PROTEIN EXPRESSION IN HUMAN
LYMPHOCYTES. A. Salazar1, M. Sordo1, E.
Miranda-Gonzalez1, 2 and P. Ostrosky-Wegman1.
1
Instituto de Investigaciones Biomedicas,
Universidad Nacional Autonoma de Mexico,
Mexico, D.F., Mexico and 2Posgrado de la Facultad
de Quimica, Universidad Nacional Autonoma de
Mexico, Mexico D.F., Mexico. Sponsor: J. States.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: GENE REGULATION II
Chairperson(s): Kevin Gaido, CIIT Centers for Health Research, Research
Triangle Park, NC and Alvaro Puga, University of Cincinnati, Cincinnati,
OH.
PROTECTIVE ROLE OF CAFFEIC
ACID PHENETHYL ESTER (CAPE) ON
BI-FUNCTIONAL ALKYLATING AGENTINDUCED TOXICITY IN KERATINOCYTES
VIA MODULATION OF NF-KB, P53 AND
ARE/EPRE SIGNALING. G. D. Minsavage and
J. F. Dillman. Cell and Molecular Biology Branch,
INHIBITION OF P65 NUCLEAR
TRANSLOCATION BY RADICICOL,
HSP90 INHIBITOR. Y. J. Jeon1 and K. Y. Lee2.
1
Pharmacology, Chosun University, Kwangju, South
Korea and 2Bionano Center, KRIBB, Taejeon, South
Korea. Sponsor: H. Kim.
#1357
CROCIDOLITE EXPOSURE INCREASES NFκB DNA BINDING ON THE INOS PROMOTER
IN A549 CELLS. L. Buelow and A. E. Aust.
Chemistry and Biochemistry, Utah State University,
Logan, UT. Sponsor: J. Veranth.
#1358
RELATIONSHIP BETWEEN DRUGINDUCED INOS-2 GENE INDUCTION AND
P450 GENE REPRESSION: MECHANISTIC
DIFFERENCES AMONG DRUG CLASSES.
B. Ganter1, A. Vladimirova1 and R. D. Snyder2.
1
Chemogenomics and Toxicology, Iconix
Pharmaceuticals, Mountain View, CA and 2ScheringPlough Research Institute, Lafayette, NJ.
TUESDAY
#1359
GLABRIDIN SUPPRESSES INTERCELLULAR
ADHESION MOLECULE-1 EXPRESSION IN
TNF-α-STIMULATED HUMAN UMBILICAL
VEIN ENDOTHELIAL CELLS BY BLOCKING
NF-κB/REL ACTIVATION. J. Kang, Y. Yoon, M.
Han, S. Han, S. Park and H. Kim. Bioevaluation
Center, Korea Research Institute of Bioscience and
Biotechnology, Taejon, South Korea.
#1360
THIOREDOXIN-2 OXIDATION BY TUMOR
NECROSIS FACTOR-ALPHA STIMULATION.
J. Hansen1, H. Zhang2 and D. P. Jones2. 1Department
of Pediatrics, Emory University, Atlanta, GA and
2
Department of Medicine, Emory University,
Atlanta, GA.
168
#1361
GENDER-DEPENDENT mRNA
EXPRESSION OF MOUSE UDPGLUCURONOSYLTRANSFERASES (UGTS):
REGULATION BY ANDROGENS AND
MALE-PATTERN GROWTH HORMONE
SECRETION. D. B. Buckley, J. M. Maher, X.
Cheng and C. D. Klaassen. University of Kansas
Medical Center, Kansas City, KS.
#1362
UVB-INDUCES C/EBP ALPHA THROUGH A
P53-INDEPENDENT PATHWAY INVOLVING
C/EBP BETA IN PRIMARY FIBROBLASTS. R.
Ranjan1, K. Yoon2 and R. C. Smart1. 1Cell Signaling
and Cancer Group, Department of Environmental
and Molecular Toxicology, North Carolina
State University, Raleigh, NC and 2Center for
Environmental and Genetic Medicine, Institute of
Biosciences and Technology, Houston, TX.
#1363
TISSUE DISTRIBUTION, ONTOGENIC
EXPRESSION AND REGULATION OF
SULFOTRANSFERASES BY PROTOTYPICAL
MICROSOMAL INDUCERS IN MICE. Y.
M. Alnouti and C. D. Klaassen. Pharmacology,
Toxicology & Therapeutics, University of Kansas
#1364
USING IN VIVO FOOTPRINTING TO
DETERMINE ALTERED TRANSCRIPTION
FACTOR BINDING AFTER PHTHALATE
TREATMENT. A. Kuhl, S. Ross and K. Gaido.
CIIT Centers for Health Research, Research Triangle
Park, NC.
#1365
REGULATION BY NUCLEAR FACTOR I OF
THE LYSYL OXIDASE GENE EXPRESSION
IN RAT LUNG FIBROBLASTS IN RESPONSE
TO ENVIRONMENTAL FACTORS. S. Gao1,
Y. Zhao1, I. Chou2, P. Toselli1, P. Stone1 and W.
Li1. 1Biochemistry, Boston University School of
Medicine, Boston, MA and 2Microbiology, Boston
#1366
EARLY GROWTH RESPONSE FACTOR-1
IS CRITICAL FOR CHOLESTATIC LIVER
INJURY. B. Copple1, A. Slitt1 and N. Kim1, 2.
1
Pharmacology, Toxicology, and Therapeutics,
KS and 2Department of Pharmacy, Pusan Nation
University, Busan, South Korea.
#1367
UP-REGULATION OF NAD(P)H QUINONE
OXIDOREDUCTASE 1 DURING HUMAN
LIVER INJURY. M. Goedken, L. M. Aleksunes
and J. E. Manautou. Department Pharmacology
Sciences., University of Connecticut, Storrs, CT.
45th Annual
Meeting & ToxExpo
#1368
#1369
#1370
#1371
ETHANOL INDUCES AND INSULIN
INHIBITS ALCOHOL DEHYDROGENASE
CLASS 1 IN FGC-4 CELLS: BOTH APPEAR
TO WORK THROUGH SREBP-1. L. He1, 3, F.
A. Simmen1, 3, M. J. Ronis2, 3 and T. M. Badger1,
3 1
. Physiology & Biophysics, University of
Arkansas for Medical Sciences, Little Rock,
AR, 2Pharmacology & Toxicology, University of
Arkansas for Medical Sciences, Little Rock, AR and
3
Arkansas Children’s Nutrition Center, Little Rock,
AR.
3, 3-DIINDOLYLMETHANE (DIM) DOWNREGULATES THE CHEMOKINE, CXCL12,
AND ITS RECEPTOR, CXCR4, IN BREAST
AND OVARIAN CANCER CELLS. E. L. Hsu, R.
C. Aarnaes, S. Fawcett and O. Hankinson. Molecular
Toxicology, UCLA, Los Angeles, CA.
FUNCTIONAL PROPERTIES OF
AN ALTERNATIVE, TISSUESPECIFIC PROMOTER FOR THE
N-ACETYLTRANSFERASE-1 GENE, NAT1.
D. F. Barker, A. Husain, J. R. Neale, B. D. Martini,
X. Zhang, M. A. Doll, J. States and D. W. Hein.
Department of Pharmacology & Toxicology and
Brown Cancer Center, University of Louisville,
Louisville, KY.
INDUCTION OF HEME OXYGENASE-1
EXPRESSION BY THE ISOFLAVONOIDS
ISOLATED FROM PUERARIA RADIX. C.
Choi1, J. Kim2, 3, K. Oh2, 3, E. Han2, 3, Y. Hwang2, 3,
D. Kim4 and H. Jeong2, 3. 1Division of Food Science,
Chinju International University, Chinju, South
Korea, 2Pharmacy, Chosun University, Kwangju,
South Korea, 3Research Center for Proteineous
Korea and 4Pathology, College of Oriental Medicine,
Daejeon University, Daejeon, South Korea.
#1372
INDUCTION OF CYCLOOXYGENASE2 BY GLUCOCORTICOIDS IN
CARDIOMYOCYTES. H. Sun. Pharmacology,
#1373
THE EFFECT OF CIGARETTE SMOKE
CONDENSATE ON RESPIRATORY
SYNCYTIAL VIRUS INDUCED
INFLAMMATORY CHEMOKINES. S. Castro1, 2,
A. Casola2 and R. P. Garofalo2. 1Pharmacology and
Toxicology, University of Texas Medical Branch,
Galveston, TX and 2Pediatrics, University of Texas
Medical Branch, Galveston, TX. Sponsor: M.
Treinen-Moslen.
#1374
N27 DOPAMINERGIC CELL LINE: A USEFUL
MODEL FOR STUDYING THE MECHANISMS
OF ACTION OF FUNCTIONALLY
SELECTIVE DOPAMINERGIC COMPOUNDS.
J. D. Urban1, J. Jin2 and R. B. Mailman3, 1.
1
Curriculum in Toxicology, UNC Chapel Hill,
Chapel Hill, NC, 2Bioinformatics, UNC Chapel Hill,
Chapel Hill, NC and 3Psychiatry, UNC Chapel Hill,
Chapel Hill, NC.
169
#1375
METAL INDUCED ACTIVATION OF
METALLOTHIONEIN GENE EXPRESSION. E.
S. Craft and J. H. Freedman. Nicholas School, Duke
#1376
PB EXPOSURE REGULATES A COMPLEX
INTERPLAY OF SIGNALING PATHWAYS
IN ARTICULAR CHONDROCYTES
THAT ULTIMATELY LEADS TO
PHENOTYPIC CHANGES RESEMBLING
OSTEOARTHRITIS. M. J. Zuscik, E. Puzas, R.
J. O’Keefe, T. Sheu, J. D. Holz, E. M. Schwarz, R.
N. Rosier and R. Ubayawardena. Department of
Orthopaedics, University of Rochester School of
Medicine, Rochester, NY.
#1377
EFFECTS OF CHROMIUM ON THE
BENZO[A]PYRENE-INDUCE GENE
EXPRESSION IN MOUSE HEPATOMA
HEPA-1 CELLS. M. Schnekenburger and A. Puga.
Department of Environmental Health, University of
Cincinnati, College of Medicine, Cincinnati, OH.
#1378
A CLEARANCE SYSTEM PROPOSED
FOR PARAQUAT-INDUCED PULMONARY
FIBROSIS IN RATS. Y. Satomi1, 2, W. Tsuchiya1, K.
Mihara2, M. Kobayashi1, T. Kobayashi1, Y. Kasahara1
and F. Akahori2. 1Teijin Institute for Bio-medical
Research, TEIJIN PHARMA LIMITED, Tokyo,
Japan and 2School of Veterinary Medicine, Azabu
University, Kanagawa, Japan.
#1379
MODULATION OF CALCINEURIN ACTIVITY
BY ZINC IN ADRIAMYCIN-TREATED
H9C2 RAT CARDIAC MUSCLE CELLS.
K. E. Merten1, Y. Jiang2, W. Feng2 and Y. Kang1,
2 1
. Pharmacology and Toxicology, University
of Louisville, Louisville, KY and 2Medicine,
#1380
EFFECTS OF OXIDATIVE STRESS ON
G-PROTEIN-RECEPTOR-KINASE 2
DEGRADATION. K. Hoffman, D. A. Jackson and
D. M. Shepherd. Biomedical and Pharmaceutical
Sciences, University of Montana, Missoula, MT.
#1381
HISTONE H3 PHOSPHORYLATION
PATTERNS IN RESPONSE TO DNADAMAGING AGENTS. R. Xie, S. S. Lau and T. J.
Monks. Pharmacology and Toxicolocy, University of
Arizona Health Sciences Center, Tucson, AZ.
#1382
REDOX SIGNALING AND SPATIAL REARRANGEMENT OF VE-CADHERIN,
ICAM-1, AND CD11B ADHESION
MOLECULES ASSOCIATED WITH
ALVEOLAR IRON CYCLING IN A MODEL
OF HEMORRHAGIC LUNG INJURY. N. V.
Gorbunov1, D. K. Das2 and J. L. Atkins1. 1MCR,
Walter Reed Army Institute of Research, Silver
Spring, MD and 2School of Medicine, University of
Connecticut, Farmington, CT.
#1383
CHANGES IN CA2+ OSCILLATIONS
IN HUMAN MYOMETRIAL CELLS
ASSOCIATED WITH TOXICANT EXPOSURE.
R. Barhoumi, I. Awooda and R. C. Burghardt.
Veterinary Integrative Biosciences, Texas A&M
TUESDAY
45th Annual
Meeting & ToxExpo
#1384
CHOLESTEROL SECOALDEHYDE INDUCES
APOPTOTIC SIGNALING THROUGH
MITOCHONDRIAL PATHWAY IN H9C2
CARDIOMYOBLASTS. K. Sathishkumar and R.
M. Uppu. Environmental Toxicology and Health
Research Center, Southern University and A&M
College, Baton Rouge, LA.
#1385
CHARACTERIZATION OF TRPM8
RECEPTORS IN HUMAN RESPIRATORY
EPITHELIAL CELLS. A. S. Sabnis, G. S. Yost and
C. A. Reilly. Pharmacology & Toxicology, University
of Utah, Salt Lake City, UT.
#1386
#1390
INDUCTION OF NECROSIS BY SAUROPUS
ANDROGYNOUS IN NIH3T3 FIBROBLASTS.
S. Yu1 and Y. Chen1, 2, 3. 1Pharmacy, College of
Medicine, National Taiwan University, Taipei,
Taiwan, 2Clinical Pharmacy, College of Medicine,
National Taiwan University, Taipei, Taiwan and
3
Pharmacy, National Taiwan University Hospital,
Taipei, Taiwan. Sponsor: T. Ueng.
#1391
IMMUNOSTIMULATORY HERBAL
EXTRACTS INHIBIT B16/F10 LUNG COLONY
FORMATION IN IMMUNOCOMPETANT
C57BL/6 MICE BUT NOT IN MICE
SELECTIVELY DEPLETED OF NK CELLS
OR PERIPHERAL MACROPHAGES. S.
Groom1, 2 and T. Johns2. 1Toxicology, Charles River
Laboratories Preclinical Montréal, Senneville,
QC, Canada and 2School of Dietetics and Human
Nutrition University of McGill, Montréal, QC,
Canada. Sponsor: M. Vezina.
#1392
INVESTIGATION OF THE MECHANISM OF
RUBRATOXIN B-INDUCED INTERLEUKIN-6
SECRETION. H. Nagashima, H. Nakagawa and K.
Iwashita. National Food Research Institute, Tsukuba,
Ibaraki, Japan. Sponsor: M. Fukayama.
#1393
ACTEOSIDE INHIBITS PHORBOL
ESTER-INDUCED CYCLOOXYGENASE-2
EXPRESSION THROUGH BLOCKING OF NFκB AND AP-1 ACTIVATION. E. Woo1, 2, E. Han1, 2,
J. Kim1, K. Oh1, 2, H. Kim2, 1, D. Kim3 and H. Jeong1,
2 1
. Pharmacy, Chosun University, Kwangju, South
Korea, 2Research Center for Proteineous Materials,
3
Pathology, College of Oriental Medicine, Daejeon
University, Daejeon, South Korea.
#1394
FUMONISIN MODULATES CYTOKINE
EXPRESSION AND DIFFERENTIALLY
ACTIVATES MITOGEN-ACTIVATED
PROTEIN KINASES IN MOUSE LIVER.
H. Suzuki, Q. He, N. Sharma and R. P. Sharma.
Physiology & Pharmacology, The University of
Georgia, Athens, GA.
#1395
DELETION OF INTERLEUKIN-12 GENE
IN MICE ABROGATES FUMONISIN
B1-INDUCED HEPATIC CYTOKINE
ALTERATIONS WITHOUT REDUCING
HEPATOTOXICITY. R. P. Sharma, Q. He, N.
Sharma and H. Suzuki. Physiology & Pharmacology,
University of Georgia, Athens, GA.
#1396
DIFFERENTIAL RELEASE OF TNFALPHA AND TGF-BETA 1 BY RAT
MICROGLIA EXPOSED TO E. COLI
LIPOPOLYSACCHARIDE AND THE MARINE
TOXIN DOMOIC ACID. A. M. Mayer1, R.
L. Peksa1, M. L. Hall1 and P. B. Jacobson2.
1
Pharmacology, Midwestern University, Downers
Grove, IL and 2Metabolic Disease Research, Abbott
GENE EXPRESSION AND PROTEIN
PRENYLATION CHANGES DURING STATININDUCED MUSCLE TOXICITY IN THE RAT.
J. E. Sidaway, P. D. Glaves, K. Lowry, F. Westwood,
A. M. Marsden, T. C. Orton and R. C. Scott. Safety
Assessment, AstraZeneca, Macclefield, Cheshire,
United Kingdom.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: NATURAL PRODUCTS
Chairperson(s): Rhonda Rosengren, University of Otago, Dunedin, New
Zealand and Edmond Creppy, University of Bordeaux, Bordeaux, France.
#1387
TUESDAY
#1388
#1389
COMPARATIVE STUDY OF CYTOTOXICITY
AND OXIDATIVE STRESS INDUCED BY
DEOXYNIVALENOL, ZEARALENONE
OR FUMONISIN B1 IN CACO-2 CELLS.
E. E. Creppy1, J. H. Kouadio1, T. A. Mobio1, I.
Baudrimont1, S. Moukha2, 1 and S. D. Dano3.
1
Toxicology, University Bordeaux 2, Bordeaux,
France, 2UPR 1264 MycSA, INRA, Villenave
d’Ornon, France and 3Faculty of Pharmacy,
University of Abidjan, Abidjan, France.
ANTAGONISTIC AND SYNERGISTIC
EFFECTS OF ZEARALENONE AND
FUMONISIN B1 IN HUMAN INTESTINAL
CACO-2 CELLS LINE. E. E. Creppy1, J.
H. Kouadio1, S. Moukha2, 1 and S. D. Dano3.
1
Toxicology, University Bordeaux 2, Bordeaux,
France, 2UPR 1264 MycSA, INRA, Villenave
d’Ornon, France and 3Faculty of Pharmacy,
University of Abidjan, Abidjan Cote d’Ivoire,
France.
ANTI-OXIDATIVE EFFECTS OF
QUERCETIN-GLYCOSIDES ISOLATED
FROM THE FLOWER BUDS OF TUSSILAGO
FARFARA L. K. Kang1, J. Yang1, M. Kim2, Q.
Liu1, E. Woo1, 2 and S. Kim3. 1College of Pharmacy,
Chosun University, Gwangju, South Korea,
2
University, Gwangju, South Korea and 3College
of Pharmacy and Research Center for Transgenic
Cloned Pigs, Chungnam National University,
Daejun, South Korea. Sponsor: H. Jeong.
170
45th Annual
Meeting & ToxExpo
#1397
NOTOGINSENG REDUCES LPS-INDUCED
PRO-INFLAMMATORY MEDIATORS AND
LDL UPTAKE IN MURINE BONE MARROWDERIVED DENDRITIC CELLS. A. Rhule2, J. R.
Smith2 and D. M. Shepherd1, 2. 1CEHS, University
of Montana, Missoula, MT and 2Biomedical &
Pharmaceutical Sciences, University of Montana,
Missoula, MT.
#1404
EFFECT OF FESCUE TOXICOSIS ON
HEPATIC GENE EXPRESSION. R. S. Settivari1,
T. Evans2, E. Antoniou1, C. S. Reddy3 and D. E.
Spiers1. 1Animal Sciences, University of Missouri,
Columbia, MO, 2Veterinary Medical Diagnostic
Laboratory, University of Missouri, Columbia, MO
and 3Veterinary Biomedical Sciences, University of
Missouri, Columbia, MO.
#1398
A NUTRIENT MIXTURE ATTENUATES
ACETAMINOPHEN HEPATIC AND RENAL
TOXICITY IN ICR MICE. M. Roomi, V. Ivanov,
A. Niedzwiecki and M. Rath. Dr. Rath Research
Institute, Santa Clara, CA.
#1405
#1399
THE COMBINATION OF CURCUMIN
AND EPIGALLOCATECHIN GALLATE
SYNERGISTICALLY ELICITS G2 ARREST
IN MDA-MB-231 HUMAN BREAST CANCER
CELLS. R. J. Rosengren and T. Somers-Edgar.
Pharmacology & Toxicology, Univeristy of Otago,
Dunedin, New Zealand.
THE ADDED EFFECTS OF HEAT STRESS ON
ALTERATIONS IN MURINE HEPATIC GENE
EXPRESSION ASSOCIATED WITH FESCUE
TOXICOSIS. S. S. Bhusari1, L. B. Hearne2, D.
E. Spiers1, W. R. Lamberson1 and E. Antoniou1.
1
Animal Science Research Center, University of
Missouri, Columbia, MO and 2Statistics, University
of Missouri, Columbia, MO. Sponsor: T. Evans.
#1406
IDENTIFICATION OF ERGOTOXINS
PRODUCED FROM ENDOPHYTE-INFECTED
TALL FESCUE AND PERENNIAL RYEGRASS.
J. M. Duringer1, A. F. Lehner2, C. T. Estill3 and A.
Craig3. 1Environmental and Molecular Toxicology,
Oregon State University, Corvallis, OR, 2College
of Agriculture, Livestock Disease and Diagnostic
Center, University of Kentucky, Lexington, KY
and 3College of Veterinary Medicine, Oregon State
University, Corvallis, OR.
#1407
INHIBITORY EFFECT OF THE SAPONINS
DERIVED FROM ROOTS OF PLATYCODON
GRANDIFLORUM ON CARRAGEENANINDUCED INFLAMMATION. S. Yang3, J.
Kim1, D. Kim3, Y. Hwang1, 2, K. Oh1, 2, Y. Chung4,
S. Roh5 and H. Jeong1, 2. 1Pharmacy, Chosun
University, Kwangju, South Korea, 2Research Center
Kwangju, South Korea, 3Pathology, College of
Oriental Medicine, Daejeon University, Daejeon,
South Korea, 4Division of Food Science, Chinju
International University, Chinju, South Korea
and 5Jangsaeng Doraji Research Institute of
Biotechnology, Jangsaeng Doraji Co., Ltd., Chinju,
South Korea.
#1408
INHIBITORY EFFECT OF THE
COFFEE DITERPENE KAHWEOL ON
CARRAGEENAN-INDUCED INFLAMMATION
IN RATS. D. Kim1, J. Kim2 and H. Jeong2.
1
#1409
THE COFFEE DITERPENE KAHWEOL
INHIBITS TUMOR NECROSIS FACTORα-INDUCED EXPRESSION OF CELL
ADHESION MOLECULES IN ENDOTHELIAL
CELLS. D. Lim1, J. Choi1, 2, D. Kim3, J. Kim1,
H. Kim1, 2, Y. Hwang1, 2, K. Lee1 and H. Jeong1, 2.
1
Korea, 2College of Pharmacy, Research Center for
South Korea and 3Pathology, College of Oriental
Medicine, Daejeon University, Daejeon, South
Korea.
#1400
TUNGTUNGMADIC ACID, A NOVEL
ANTIOXIDANT, FROM SALICORNIA
HERBACEA. Y. Chung1, H. Chun2, J. Kim3, K.
Oh3, Y. Hwang3, Y. Kho2 and H. Jeong3. 1Division
of Food Science, Chinju International University,
Chinju, South Korea, 2Korea Research Institute of
Bioscience and Biotechnology, Taejon, South Korea
and 3Pharmacy, Chosun University, Kwangju, South
Korea.
#1401
FRACTIONATION OF THE AQUEOUS
EXTRACTS OF MEXICAN STRAIN
OF LENTINUS LEPIDEUS WITH
IMMUNOMODULATING ACTIVITY. L. GarzaOcanas1, R. Xochitl S.1, G. Fortunato2, A. Yolanda1,
S. Mario Cesar3 and T. Oscar1. 1Farmacologia
y Toxicologia, Facultad de Medicina, UANL,
Monterrey, Nuevo Leon, Mexico, 2Silvicultura,
Facultad de Ciencias Forestales UANL, Monterrey,
Nuevo Leon, Mexico and 3Inmunologia, Facultad de
Medicina UANL, Monterrey, Nuevo Leon, Mexico.
#1402
STRUCTURE-ACTVITY STUDY OF
FLAVONOIDS WITH MITOCHONDRIAL
ENERGETIC PROCESS. D. Dorta, A. F. CalgaroHelena, S. C. Antonio and C. Curti. University
of Sao Paulo, Ribeirao Preto, Brazil. Sponsor: K.
Wallace.
#1403
18-β GLYCYRRHETINIC ACIDINDUCED HEPATIC EXPRESSION OF
METALLOTHIONEIN IS MEDIATED BY
CYTOKINES. H. Kim1, K. Oh1, 2, H. Kim1, 2, J.
Kim1, 2, E. Han1, 2, Y. Hwang1, 2, D. Kim3 and H.
171
TUESDAY
45th Annual
Meeting & ToxExpo
#1410
#1411
#1412
TUESDAY
#1413
SUPPRESSIVE EFFECTS OF THE SAPONINS
DERIVED FROM ROOTS OF PLATYCODON
GRANDIFLORUM ON EXPRESSION OF
ADHESION MOLECULES IN HUMAN
ENDOTHELIAL CELLS. Y. Cho1, J. Y. Kim1,
Y. Hwang1, 2, D. Kim3, Y. Chung4, S. Roh5 and H.
Korea, 3Pathology, College of Oriental Medicine,
Daejeon University, Daejeon, South Korea, 4Division
of Food Science, Chinju International University,
Chinju, South Korea and 5Jangsaeng Doraji
Research Institute of Biotechnology, Jangsaeng
Doraji Co., Ltd., Chinju, South Korea.
INHIBITORY EFFECTS OF THE
POLYSACCHARIDES ISOLATED FROM THE
RADIX OF PLATYCODON GRANDIFLORUM
ON TUMOR INVASION AND METASTASIS.
H. Jeong1, 2, J. Kim1, K. Lee1, H. Kim1, 2, J. Choi1,
2
, Y. Chung3 and S. Roh4. 1Pharmacy, Chosun
University, Kwangju, South Korea, 2Research Center
Kwangju, South Korea, 3Division of Food Science,
Chinju International University, Chinju, South
Korea and 4Jangsaeng Doraji Research Institute of
Biotechnology, Jangsaeng Doraji Co., Ltd., Chinju,
South Korea.
PREVENTIVE EFFECT OF SAPONINS
DERIVED FROM ROOTS OF
PLATYCODON GRANDIFLORUM
ON 4-(METHYLNITROSAMINO)-1-(3PYRIDYL)-1-BUTANONE-INDUCED LUNG
TUMORIGENESIS IN A/J MICE. S. Roh1, J.
Choi2, 3, J. Kim2, K. Lee2, Y. Hwang2, 3, Y. Chung4 and
H. Jeong2, 3. 1Jangsaeng Doraji Research Institute
of Biotechnology, Jangsaeng Doraji Co., Ltd.,
Chinju, South Korea, 2Pharmacy, Chosun University,
Kwangju, South Korea, 3Research Center for
South Korea and 4Division of Food Science, Chinju
International University, Chinju, South Korea.
ANTIMUTAGENIC, ANTIOXIDATIVE, AND
ANTICARCINOGEGNIC EFFECTS OF
KOREAN PEARS. M. Yang1, C. Park2 and D. Kim3.
1
Department of Toxicology, Sookmyung Women’s
University College of Pharmacy, Seoul, South
Korea, 2Department of Microbiology, Hanyang
University College of Medicine, Seoul, South Korea
and 3College of Veterinary Medicine & Research
Institute of Veterinary Medicine, Chungbuk National
University, Cheongju, South Korea.
#1414
MOLECULAR MANIFESTATIONS OF BORIC
ACID-INDUCED TOXICITY IN DU-145
PROSTATE CANCER CELLS. W. T. Barranco
and C. D. Eckhert. Molecular Toxicology, UCLA,
Los Angeles, CA.
#1415
BORIC ACID INDUCES ER STRESS IN
DU-145 AND LNCAP PROSTATE CANCER
CELL LINES. K. A. Henderson1 and C. Eckhert2.
1
Molecular Toxicology IDP, UCLA, Los Angeles,
CA and 2Environmental Health Sciences, UCLA,
Los Angeles, CA.
172
#1416
BIOMARKER PROFILES OF ECHINACEA
SPECIES USING PRESSURE CYCLING
TECHNOLOGY AND MALDI-TOF MASS
SPECTROMETRY. R. Harris, D. Gray, J. Guthrie,
L. Greene and S. Schwartz. Midwest Research
Institute, Kansas City, MO. Sponsor: B. Astroff.
#1417
COLLABORATIVE LABORATORY STUDY
OF A METHOD TO DETERMINE FLAVONOL
AGLYCONES IN GINKGO BILOBA DIETARY
SUPPLEMENT CRUDE MATERIALS AND
FINISHED PRODUCTS. D. Gray1, R. Harris1, L.
Kerri2, M. Pan2 and E. Waysek3. 1Midwest Research
Institute, Kansas City, MO, 2NSF International,
Ann Arbor, MI and 3Caravan Products, Totawa, NJ.
Sponsor: B. Astroff.
#1418
IN VITRO TOXICITY IN CHO CELLS
OF HERBS COMMONLY USED BY
POSTMENOPAUSAL WOMEN. D. N.
Sujjavanich and J. E. Gibson. Pharmacology and
Toxicology, The Brody School of Medicine at East
Carolina University, Greenville, NC.
#1419
EFFECTS OF COMMERCIAL DIGESTIVE
AIDS AND ACARBOSE ON STARCH
FEEDING IN MICE. K. T. Knecht1, S. A. Gerten2
and M. M. Knecht3. 1Pharmaceutical Sciences, Loma
Linda University, Loma Linda, CA, 2Columbus
Grove High School, Columbus Grove, OH and
3
Xenium Roundtable, Loma Linda, CA. Sponsor: M.
Kadiiska.
#1420
LONG TERM SAFETY AND
TOXICOLOGICAL EVALUATION OF NOVEL
NIACIN-BOUND CHROMIUM. M. Shara, A.
Kincaid, A. Limpach, R. Sandstrom and D. Bagchi.
Pharmacy Science, Creighton University, Omaha,
NE.
#1421
A FIFTY-TWO WEEK ORAL TOXICITY
STUDY OF PURPLE SWEET POTATO COLOR
IN F344 RATS. T. Ichihara1, 2, K. Nabae1, 2, A.
Hagiwara1, N. Imai1, S. Tamano1, Y. Shibahara3,
Y. Tsushima3, T. Koda3, M. Nakamura3 and T.
Shirai2. 1DIMS Institute of Medical Science, Inc.,
Ichinomiya, Japan, 2Department of Experimental
Pathology and Tumor Biology, Nagoya City
University Graduate School of Medical Sciences,
Nagoya, Japan and 3San-Ei Gen F.F.I., Inc.,
Toyonaka, Japan.
#1422
SUBCHRONIC TOXICITY OF β-MYRCENE
IN ADMINSTERED BY GAVAGE TO FISCHER
344 RATS AND B6C3F1 MICE. D. F. Gerken1,
M. J. Ryan1, D. Y. Vasconcelos1, S. W. Graves1, M.
R. Hejtmancik1, D. Orzech2 and P. Chan2. 1TOXBC,
Battelle Science and Technology, Inc., Columbus,
OH and 2NIEHS, Research Triangle Park, NC.
45th Annual
Meeting & ToxExpo
#1423
LACK OF EFFECTS OF A TOMATO
LYCOPENE PRODUCT, A NATURAL FOOD
COLOR, IN A 28-DAY ORAL TOXICITY
STUDY IN WISTAR RATS. Y. Doi1, 2, A.
Hagiwara1, M. Kawabe1, Y. Toda1, T. Ichihara1, 2, N.
Inada3, A. Nishida3, Y. Sasaki3 and T. Shirai2. 1DIMS
Institute of Medical Science, Inc., Ichinomiya,
Japan, 2Department of Experimental Pathology and
Tumor Biology, Nagoya City University Graduate
School of Medical Sciences, Nagoya, Japan and
3
San-Ei Gen F.F.I., Inc., Toyonaka, Japan.
#1428
A RETROSPECTIVE REVIEW OF
DEVELOPMENTAL NEUROTOXICITY
STUDIES UTILIZING GAVAGE DOSING OF
PRE-WEANING RATS DEMONSTRATES NO
ADVERSE CONSEQUENCES OF DOSING
PROCEDURES ON BRAIN MORPHOMETRY.
S. L. Makris1, K. M. Crofton2, J. Doherty3, K.
C. Raffaele3, E. Mendez3 and K. Schumacher3.
1
ORD/NCEA, U.S. EPA, Washington, DC, 2ORD/
NHEERL, U.S. EPA, Research Triangle Park, NC
and 3OPP, U.S. EPA, Washington, DC.
#1424
SCREENING OF NIGERIAN SHELLFISH
FOR “DIARRHETIC” TYPE SHELLFISH
POISONING (DSP). I. Universtiy of. Asuzu and O.
O. Igboeli. Veterinary Physiology & Pharmacology,
University of Nigeria, Nsukka, Nsukka, Enugu,
Nigeria.
#1429
ON THE USE OF NEURO-2A
NEUROBLASTOMA CELLS VERSUS INTACT
NEURONS IN PRIMARY CULTURE FOR
NEUROTOXICITY STUDIES. K. T. LePage1, W.
H. Gerwick2, R. W. Dickey3, E. L. Jester3 and T. F.
Murray1. 1Physiology and Pharmacology, University
of Georgia, Athens, GA, 2Oregon State University,
Corvallis, OR and 3FDA Gulf Coast Seafood
Laboratory, Dauphin Island, AL.
#1430
ONTOGENY OF PROTEINS ASSOCIATED
WITH NEURITE GROWTH AND
SYNAPTOGENESIS IN CEREBELLAR
GRANULE CELLS IN VITRO. W. R. Mundy, T. M.
Freudenrich, B. L. Robinette and C. A. Rothermund.
Neurotoxicology Division, U.S. EPA, Research
Triangle Park, NC.
#1431
EVALUATION OF LEARNING AND
MEMORY IN DEVELOPMENTAL
NEUROTOXICITY STUDIES: COMPARISON
OF SINGLE-CHOICE WATER MAZE
ACROSS LABORATORIES. K. Raffaele1, M.
Gilbert2, K. Crofton2, E. Mendez1, J. Doherty1, K.
Schumacher1, W. Sette3 and S. Makris4. 1OPP, U.S.
EPA, Washington, DC, 2ORD, U.S. EPA, Research
Triangle Park, NC, 3OSA, U.S. EPA, Washington,
DC and 4ORD, U.S. EPA, Washington, DC.
AGE-DEPENDENT HEPATIC AND PLASMA
METABOLISM OF DELTAMETHRIN IN
VITRO: ROLE IN ACUTE NEUROTOXICITY.
S. S. Anand1, K. Kim1, S. Padilla3, S. Muralidhara1,
H. J. Kim1, J. W. Fisher2 and J. V. Bruckner1.
1
Department Pharmacology and Biom. Sciences.,
University Georgia, Athens, GA, 2Department
Environment Health Sciences., University Georgia,
Athens, GA and 3Neurotox. Division, Universtiy
of.S.EPA, Research Triangle Park, NC.
#1432
APPLICATION OF MAGNETIC RESONANCE
IMAGING IN DEVELOPMENTAL
NEUROTOXICITY TESTING: A PILOT
STUDY. K. Johnson1, L. Ryan2, J. Davis3, A.
Elmore3, B. Guenther2, J. Marcus1 and R. R.
Maronpot1. 1Laboratory of Experimental Pathology,
NIEHS/NIH/DHHS, Research Triangle Park, NC,
2
MRPath, Durham, NC and 3Integrated Laboratory
Systems, Research Triangle Park, NC.
EFFECTS OF 6-PROPYL-2-THIOURACIL
(PTU) ON THYROID GLAND MORPHOLOGY
AND THYROID HORMONE LEVELS IN
WISTAR RATS AND THEIR OFFSPRING. S.
Schneider1, W. Kaufmann1, B. van Ravenzwaay1, F.
Hess2 and C. Hastings2. 1Experimental Toxicology
and Ecology, BASF AG, Ludwigshafen, Germany
and 2Toxicology and Ecotoxicology, BASF
Corporation, Research Triangle Park, NC.
#1433
GENOMIC ANALYSIS OF PTU-INDUCED
HYPOTHYROIDISM IN THE RAT
HIPPOCAMPUS. J. E. Royland and M. E. Gilbert.
Neurotoxicology Division, U.S. EPA, Durham, NC.
#1434
DIFFERENT MECHANISMS IN
PROSTAGLANDIN H SYNTHASE
(PHS)-CATALYZED OXIDATION OF
CATECHOLAMINE NEUROTRANSMITTERS
VS. 3, 4-METHYLENEDIOXYMETHAMPH
ETAMINE AND METHAMPHETAMINE TO
FREE RADICAL INTERMEDIATES. G. P.
McCallum1 and P. G. Wells1, 2. 1Faculty of Pharmacy,
University of Toronto, Toronto, ON, Canada and
2
Department of Pharmacology, University of
Toronto, Toronto, ON, Canada.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL
Chairperson(s): Susan Makris, U.S. EPA, Washington, DC and Henrik
Viberg, Uppsala University, Uppsala, Sweden.
#1425
#1426
#1427
HISTOLOGICAL STUDY FOCUSING ON
THE FETAL BRAIN: EVALUATION OF A RAT
AUTISM MODEL INDUCED BY VALPROATE
AND THALIDOMIDE. T. Ogawa1, M. Kuwagata2, 1
and S. Shioda1. 1Anatomy, Showa University School
of Medicine, Shinagawa-ku, Japan and 2Pathology,
Hatano Research Institute, FDSC, Kanagawa, Japan.
173
TUESDAY
45th Annual
Meeting & ToxExpo
#1435
THE ROLE OF OXIDATIVE DNA DAMAGE
AND REPAIR IN METHAMPHETAMINEINITIATED NEURODEVELOPMENTAL
DEFICITS. A. W. Wong1 and P. G. Wells1, 2. 1Faculty
of Pharmacy, University of Toronto, Toronto,
ON, Canada and 2Department of Pharmacology,
University of Toronto, Toronto, ON, Canada.
#1436
DOWNREGULATION OF DEVELOPMENTAL
mRNA EXPRESSION OF IONOTROPHIC
GLUTAMATE RECEPTOR SUBUNITS
FOLLOWING GESTATIONAL EXPOSURE
TO BENZO(A)PYRENE IN F1 GENERATION
RATS. L. A. Brown and D. B. Hood. Department
of Biomedical Sciences, Division of Neurobiology
and Neurotoxicology, Center for Molecular and
Behavioral Neuroscience, Meharry Medical College,
Nashville, TN.
#1437
#1438
USE OF PROTEOMIC APPROACHES FOR
THE IDENTIFICATION OF CHANGES IN
ASTROCYTE SECRETION FOLLOWING
ETHANOL EXPOSURE. N. Moore1, M.
Guizzetti1, B. Gallis2, S. Shaffer2, D. R. Goodlett2
and L. G. Costa1. 1Department of Environmental
& Occupational Health Sciences, University of
Washington, Seattle, WA and 2Department of
Medicinal Chemistry, University of Washington,
Seattle, WA.
EFFECT OF ETHANOL ON CARBACHOLINDUCED NEURITE OUTGROWTH IN
PRENATAL HIPPOCAMPAL NEURONS.
K. L. VanDeMark, M. Guizzetti, G. Giordano
and L. G. Costa. Department of Environmental
TUESDAY
#1439
COMPARATIVE DEVELOPMENTAL
NEUROTOXICITY OF
ORGANOPHOSPHATES IN VITRO AND IN
VIVO. F. J. Seidler, E. D. Levin and T. A. Slotkin.
Superfund Basic Research Center, Duke University
Med. Ctr, Durham, NC.
#1440
CHLORPYRIFOS AFFECTS NEURONOTYPIC
CELL REPLICATION AND PHENOTYPIC
OUTCOMES DURING SPECIFIC CRITICAL
PERIODS. R. R. Jameson, F. J. Seidler, D. Qiao
and T. A. Slotkin. Pharmacol/Cancer Biol, Duke
Universtiy of Med. Ctr, Durham, NC.
#1441
CHLORPYRIFOS INHIBITS AXON
OUTGROWTH VIA DISRUPTION OF
THE MORPHOGENIC ACTIVITY OF
ACETYLCHOLINESTERASE. P. Lein1, 2, D.
Yang1, A. Howard2 and D. Bruun1. 1Center for
Research on Occupational and Environmental
Toxicology, Oregon Health & Science University,
Portland, OR and 2Environmental Health Sciences,
Johns Hopkins University Bloomberg School of
Public Health, Baltimore, MD.
174
#1442
CHRONIC DEVELOPMENTAL EXPOSURE
TO ORGANOPHOSPHATES ELEVATES
DOPAMINE LEVELS AND ALTERS
NICOTINIC ACETYLCHOLINE SUBUNIT
RNA EXPRESSION. J. B. Eells and T. Brown.
Center for Environmental Health Sciences, College
of Veterinary Medince, Mississippi State University,
Mississippi State, MS. Sponsor: J. Chambers.
#1443
EFFECTS OF REPEATED POSTNATAL
EXPOSURE TO CHLORPYRIFOS AND
METHYL PARATHION ON BDNF LEVELS
IN THE CORTEX AND HIPPOCAMPUS.
A. M. Betancourt and R. L. Carr. Center for
University, MS State, MS.
#1444
EFFECTS OF THE ORGANOPHOSPHOROUS
INSECTICIDES CHLORPYRIFOS AND
METHYL PARATHION ON MUSCARINIC
ACETYLCHOLINE RECEPTOR BINDING
IN BRAIN REGIONS OF POSTNATALLY
TREATED RATS. S. X. Guo-Ross, R. L. Carr and
J. E. Chambers. Center for Environmental Health
State, MS.
#1445
EFFECTS OF REPEATED POSTNATAL
EXPOSURE TO CHLORPYRIFOS OR
METHYL PARATHION IN THE ELEVATED
PLUS-MAZE MODEL OF ANXIETY. F. O.
Johnson, J. E. Chambers and R. L. Carr. Center For
University, Starkville, MS.
#1446
MODULATION OF LOW-LEVEL
ORGANOPHOSPHATE TOXICITY
BY HUMAN PON1, AS ASSESSED BY
MICROARRAY ANALYSIS. T. B. Cole1, 2, 3, C.
Pettan-Brewer1, 3, A. Forbes2, S. Proll4, J. Furlong4, L.
G. Costa2 and C. E. Furlong1, 3, 2. 1Medicine, Division
of Medical Genetics, University of Washington,
Seattle, WA, 2Environmental and Occupational
Health Sciences, University of Washington, Seattle,
WA, 3Genome Sciences, University of Washington,
Seattle, WA and 4Microbiology, University of
#1447
PERSISTENT NEUROBEHAVIORAL
DEFICITS AND NEUROPATHOLOGICAL
ALTERATIONS IN THE CEREBELLUM
OF ADULT OFFSPRING FOLLOWING
MATERNAL EXPOSURE TO NICOTINE
AND CHLORPYRIFOS ALONE AND IN
COMBINATION. M. B. Abou-Donia, A. AbdelRahman, A. Dechkovskaia, L. B. Goldstein, S.
Bullman and W. Khan. Pharmacology and Cancer
Biology, Duke University Medical Center, Durham,
NC.
45th Annual
Meeting & ToxExpo
#1448
EFFECTS OF GESTATIONAL TCDD
EXPOSURE ON NMDA/AMPA-DEPENDENT
SINGLE CELL RESPONSES IN ADULT RAT
SENSORY CORTEX. D. B. Hood1, L. Woods2,
S. Johnson1 and F. F. Ebner2. 1Department of
Biomedical Sciences, Division of Neurobiology
and Neurotoxicology, Center for Molecular and
Behavioral Neuroscience, Meharry Medical College,
Nashville, TN and 2Department of Psychology,
Vanderbilt University, Nashville, TN.
#1449
PRENATAL DIOXIN EXPOSURE DISRUPTS
COCHLEAR FUNCTION IN MICE. T. M. Safe1,
L. A. Opanashuk2 and A. E. Luebke1, 3. 1Biomedical
Engineering, University of Rochester Medical
Center, Rochester, NY, 2Environmental Medicine,
University of Rochester Medical Center, Rochester,
NY and 3Neurobiology & Anatomy, University of
Rochester Medical Center, Rochester, NY.
#1450
DEVELOPMENTAL EXPOSURE TO
AROCLOR 1254 IMPAIRS DENDRITIC
PLASTICITY AND FUNCTIONAL
EXPRESSION OF RYANODINE RECEPTORS
IN WEANLING RATS. D. Yang1, K. Kim2, A.
Phimister2, I. Pessah2 and P. Lein1. 1Center for
Research on Occupational and Environmental
Toxicology, Oregon Health & Science University,
Portland, OR and 2Department of VM: Molecular
Biosciences and Center for Childrens Environmental
Health, University of California at Davis, Davis,
CA.
#1451
#1452
#1453
EFFECTS OF PERINATAL EXPOSURE TO
LOW DOSES OF PCB 153 ON THE BRAIN
NEUROTRANSMITTERS OF FEMALE
OFFSPRING AND MATERNAL RATS. T.
Honma1, 3, M. Miyagawa1, R. Wang2, M. Suda3 and
K. Kobayashi3. 1Department of Research Planning,
National Institute of Industrial Health, Kawasaki,
Japan, 2Department of Hazard Assessment, National
Institute of Industrial Health, Kawasaki, Japan and
3
Department of Health Effect Research, National
Institute of Industrial Health, Kawasaki, Japan.
Sponsor: M. Chiba.
NANOMOLAR PCB 95 ALTERS IN
VITRO NEUROPLASTICITY IN THE RAT
HIPPOCAMPAL SLICE PREPARATION
AND LACTATIONAL EXPOSURE IN VIVO
ENHANCES SEIZURE SUSCEPTIBILITY. K.
Kim1, S. Y. Inan2, R. F. Berman2 and I. N. Pessah1.
1
Center for Children s Environmental Health,
Department of Molecular Biosciences: VM,
Universtiy of.C. Davis, Davis, CA and 2Department
of Neurological Surgery, UC Davis, Davis, CA.
AUDITORY IMPAIRMENTS IN
RATS EXPOSED TO PCBs DURING
DEVELOPMENT. B. E. Powers1, J. J. Widholm2,
R. E. Lasky3, D. M. Gooler1 and S. L. Schantz1.
1
Neuroscience, University of Illinois Universtiy ofC, Urbana, IL, 2Psychology, College of Charleston,
Charleston, SC and 3Health Science Center,
University of Texas, Houston, TX.
175
#1454
BEHAVIORAL EFFECTS OF PERINATAL
EXPOSURE TO PCB126 AND METHYL
MERCURY, ALONE AND IN ASSOCIATION.
A. Vitalone1, A. Catalani2, V. Chiodi2, C. Cinque2, V.
Fattori1, A. Giacomi2, P. Matteucci2, A. Zuena2 and L.
Costa3, 4. 1University of Bari, Bari, Italy, 2University
of Rome “La Sapienza”, Rome, Italy, 3University of
Washington, Seattle, WA and 4University of Parma,
Parma, Italy.
#1455
ENHANCED DEVELOPMENTAL
NEUROBEHAVIORAL DEFECTS IN MICE
NEONATALLY CO-EXPOSED TO AN ORHTOSUBSTITUTED PCB (PCB 153), CO-PLANAR
PCB (PCB 126), OR A BROMINATED FLAME
RETARDANT (PBDE 99) IN ADDITION TO
METHYLMERCURY. C. Fischer, A. Fredriksson
and P. Eriksson. Department of Environmental
Toxicology, Uppsala University, Uppsala, Sweden.
#1456
DECABROMINATED DIPHENYL ETHER
(PBDE 209) INDUCES NEUROTOXIC
EFFECTS IN THE NEONATAL AND ADULT
MOUSE AFTER NEONATAL EXPOSURE. H.
Viberg1, N. Johansson1, A. Fredriksson1, J. Eriksson2
and P. Eriksson1. 1Department of Environmental
Toxicology, Uppsala University, Uppsala, Sweden
and 2Department of Environmental Chemistry,
Stockholm University, Stockholm, Sweden.
#1457
ALTERED SYNAPTIC PLASTICITY
IN C57BL/6 MICE AFTER NEONATAL
EXPOSURE TO BDE-47. M. Dingemans1, G.
Ramakers2, R. Westerink1, M. van den Berg1 and H.
Vijverberg1. 1Institute for Risk Assessment Sciences,
Utrecht University, Utrecht, Netherlands and 2Rudolf
Magnus Institute of Neuroscience, University
Medical Center Utrecht, Utrecht, Netherlands.
#1458
NEONATAL EXPOSURE TO
PERFLUOROOCTANE SULFONATE (PFOS)
AND PERFLUOROOCTANOIC ACID (PFOA)
CAUSE DERANGED BEHAVIOUR AND
INCREASED SUSCEPTIBILITY OF THE
CHOLINERGIC SYSTEM IN ADULT MICE.
N. Johansson, A. Fredriksson and P. Eriksson.
Department of Environmental Toxicology, Uppsala
University, Uppsala, Sweden.
#1459
EFFECTS OF CHRONIC, LOW-DOSE
ACRYLAMIDE TREATMENT ON SPATIAL
LEARNING AND NEURODEVELOPMENT IN
FISCHER 344 RATS. J. Garey, S. A. Ferguson and
M. G. Paule. Neurotoxicology, National Center for
Toxicological Research/U.S. FDA, Jefferson, AR.
#1460
HYPERACTIVITY INDUCED BY EXPOSURE
TO A PRENATAL GENOTOXIC AGENT,
BRDU, ACROSS RODENT SPECIES, STRAINS
AND GENDER. M. Kuwagata1, 2, H. Ohmukai1,
T. Ogawa2, S. Shioda2 and T. Nagata1. 1Toxicology,
Hatano Research Institute, Kanagawa, Japan and
2
Anatomy I, Showa University, School of Medicine,
Tokyo, Japan.
TUESDAY
45th Annual
Meeting & ToxExpo
#1461
EVALUATION OF CHANGES IN
HIPPOCAMPAL GENE EXPRESSION
ASSOCIATED WITH THE BEHAVIORAL
TOXICITY CAUSED BY CHRONIC
DEVELOPMENTAL KETAMINE OR
REMACEMIDE TREATMENT IN RATS.
L. K. Wright2, 1, T. A. Patterson1, E. Pearson3, T.
G. Hammond3 and M. G. Paule1, 2. 1Division of
Neurotoxicology, National Center for Toxicological
Research, Jefferson, AR, 2Department of
Arkansas for Medical Sciences, Little Rock, AR
and 3Safety Assessment, AstraZeneca, Leics, United
Kingdom.
Tuesday, March 7
1:30 PM to 4:30 PM
Exhibit Hall
#1467
DELAYED NEUROTOXICITY IN CHICKENS:
90-DAY STUDY WITH MOBIL JET OIL 254.
W. C. Daughtrey1, R. W. Biles1, B. S. Jortner2 and M.
F. Ehrich2. 1Toxicology & Environmental Sciences,
ExxonMobil Biomedical Sciences, Annandale,
NJ and 2VA MD Regional College of Vet. Med.,
Virginia Tech, Blacksburg, VA.
#1468
TRANSFER AND ACTIVATION OF
MALATHION THROUGH AN IN VITRO
BLOOD-BRAIN BARRIER SYSTEM. M.
Ehrich1, Y. Lee1, K. Fuhrman1, D. Parran1, B.
Meldrum1 and B. Rzigalinski2. 1Virginia-Maryland
Regional College of Veterinary Medicine, Virginia
Tech, Blacksburg, VA and 2Via College of
Osteopathic Medicine, Blacksburg, VA.
#1469
CHLORPYRIFOS INDUCES BBB
DISRUPTION THROUGH UP-REGULATION
OF PRO-INFLAMMATORY MEDIATORS IN
BRAIN MICROVASCULAR ENDOTHELIAL
CELLS. Y. Lee1, 2, A. A. Hirani1 and M. Ehrich2.
1
Biomedical Engineering and Sciences, Virginia
Tech, Blacksburg, VA and 2Biomedical Sciences and
#1470
EARLY INTRACELLULAR SIGNALING IN
SH-SY5Y CELLS AFTER EXPOSURE TO
NEUROPATHIC AND NON-NEUROPATHIC
ORGANOPHOSPHATES. M. J. Pomeroy-Black1,
B. S. Jortner2 and M. F. Ehrich2. 1Department
of Biology, LaGrange College, LaGrange, GA
and 2Department of Biomedical Science and
#1471
CHANGES IN BDNF AND NGF GENE
EXPRESSION IN ORGANOTYPIC SLICES
OF THE CORTEX AND HIPPOCAMPUS
EXPOSED TO CHLORPYRIFOS AND
CHLORPYRIFOS-OXON. R. L. Carr and A.
M. Betancourt. Center for Environmental Health
State, MS.
#1472
REACTIVE OXYGEN SPECIES MEDIATE
THE NEUROTOXICITY INDUCED BY
ORGANOPHOSPHORUS INSECTICIDES IN
MOUSE CEREBELLAR GRANULE CELLS.
G. Giordano1, Z. Afsharinejad1, T. Kavanagh1 and L.
Costa1, 2. 1Environmental and Occupational Health
Sciences, University of Washington, Seattle, WA
and 2Human Anatomy, Pharmacology and Forensic
Medicine, University of Parma Medical School,
Parma, Italy.
#1473
EFFECTS OF CHLORPYRIFOS ON
CHOLINESTERASE ACTIVITY AND IN
VIVO ACETYLCHOLINE ACCUMULATION
IN STRIATUM OF ADULT RATS. S. Karanth,
N. Mirajkar, A. Ray, J. Liu and C. Pope. Center
for Veterinary Health Sciences, Oklahoma State
University, Stillwater, OK.
POSTER SESSION: NEUROTOXICITY: PESTICIDES
Chairperson(s): Jean Claude Mwanza, U.S. EPA, Research Triangle Park
and Russell Carr, Mississippi State University, Mississippi State, MS.
MODELING THE CYCLIC NUCLEOTIDE
BINDING DOMAINS OF NEUROPATHY
TARGET ESTERASE (NTE). F. Nasser1, S. J.
Wijeyesakere1, J. A. Stuckey2 and R. J. Richardson1.
1
Toxicology Program, University of Michigan, Ann
Arbor, MI and 2Life Sciences Institute, University of
Michigan, Ann Arbor, MI.
#1463
MODELING THE PATATIN DOMAIN OF
NEUROPATHY TARGET ESTERASE. S.
Wijeyesakere1, F. A. Nasser1, J. A. Stuckey2 and R.
J. Richardson1. 1Toxicology Program, University
of Michigan, Ann Arbor, MI and 2Life Sciences
Institute, University of Michigan, Ann Arbor, MI.
#1464
MOLECULAR MECHANISMS IN OPIDN:
DIFFERENTIAL EXPRESSION OF βTUBULIN SUBTYPES IN THE CENTRAL
NERVOUS SYSTEM OF HENS TREATED
WITH DIISOPROPYLPHOSPHOROFLUO
RIDATE (DFP). T. V. Damodaran1, 2 and M. B.
Abou-Donia2. 1Pediatrics, Duke University Medical
Center, Durham, NC, NC and 2Pharmacology and
Cancer Biology and Pediatrics, Duke University
Medical Center, Durham, NC.
#1465
PHENYL BENZOATE ESTERASES AND
PROMOTION OF ORGANOPHOSPHATE
DELAYED POLYNEUROPATHY (OPIDP). A.
Nicolli, M. Lotti and A. Moretto. Environmental
Medicine and Public Health, Universita’ di Padova,
Padova, Italy.
#1466
AXONAL DYSTROPHY AND WALLERIANLIKE DEGENERATION. TWO MYELINATED
NERVE FIBER LESIONS OF MULTIEXPOSURE ORGANOPHOSPHATE-INDUCED
DELAYED NEUROTOXICITY IN RATS. B. S.
Jortner, S. Hancock, J. Hinckley, J. Carter and M.
F. Ehrich. Laboratory for Neurotoxicity Studies,
Virginia Tech, Blacksburg, VA.
TUESDAY
#1462
176
45th Annual
Meeting & ToxExpo
#1474
PARATHION-INDUCED CHANGES IN RAT
BRAIN REGIONAL CITRULLINE AND
HIGH-ENERGY PHOSPHATE LEVELS
ARE ENHANCED BY SUGAR FEEDING. J.
Liu1, C. Pope1, S. Karanth1 and R. Gupta2. 1Center
for Veterinary Health Sciences, Oklahoma State
University, Stillwater, OK and 2Murray State
University, Hopkinsville, KY.
#1475
CHLORPYRIFOS AND 3, 5, 6 TRICHLORO2-PYRIDINOL DISTRIBUTION IN RAT
BLOOD AND BRAIN DURING CHRONIC
DIETARY AND REPEATED HIGH-LEVEL
ACUTE EXPOSURE TO CHLORPYRIFOS.
D. L. Hunter1, R. S. Marshall1, E. Reynolds2 and S.
Padilla1. 1NTD, U.S. EPA, Research Triangle Park,
NC and 2St. Margaret’s School, Tappahannock, VA.
#1476
AGE-RELATED DIFFERENCES OF
DETOXICATION AND INHIBITION
FROM TWELVE ORGANOPHOSPHATE
COMPOUNDS. E. C. Meek1, R. Carr1, H.
Chambers2, A. Coban1, B. Hurley1, J. Wagner1, J.
Pittman1, K. White1 and C. Janice1. 1Center for
University, Mississippi State, MS and 2Department
of Entomology, Mississippi State University,
#1477
A SIMPLE HPLC METHOD FOR
DETECTING CARBARYL AND 1-NAPHTHOL
IN BIOLOGICAL TISSUES. J. E. Graff, C. L.
Spivey and D. W. Herr. NTD/NHEERL/ORD, U.S.
#1478
RELATIONSHIPS BETWEEN TISSUE
LEVELS OF CARBARYL, A PROTOTYPICAL
N-METHYL CARBAMATE PESTICIDE,
AND CHOLINESTERASE INHIBITION IN
LONG EVANS RATS. D. W. Herr1, J. E. Graff1, R.
S. Marshall1, A. B. Lowit2 and S. Padilla1. 1NTD/
NHEERL/ORD, U.S. EPA, Research Triangle Park,
NC and 2HED/OPP/OPPTS, U.S. EPA, Washington,
DC.
#1479
#1480
#1481
INHIBITION OF BRAIN CHOLINESTERASE
AND THE PHOTIC AFTER DISCHARGE OF
FLASH EVOKED POTENTIALS PRODUCED
BY CARBARYL IN LONG EVANS RATS. J. K.
Mwanza2, J. E. Graff1, C. L. Spivey1 and D. W. Herr1.
1
NTD/NHEERL/ORD, U.S. EPA, Research Triangle
Park, NC and 2NRC, Washington, DC.
DELTAMETHRIN AND PERMETHRIN
DECREASE SPONTANEOUS NETWORK
ACTIVITY IN VITRO. S. Rijal1, G. W. Gross1 and
T. J. Shafer2. 1Department of Biological Sciences
and Center for Network Neuroscience, University
of North Texas, Denton, TX and 2Neurotoxicology
Division, NHEERL, ORD, U.S. EPA, Research
Triangle Park, NC.
DIFFERENTIAL SENSITIVITY TO
PYRETHROIDS OF SODIUM CHANNEL
NaV1.2/β1 EXPRESSED IN XENOPUS
OOCYTES. C. A. Meacham1, J. A. Watkins2 and T.
J. Shafer1. 1Neurotoxicology, U.S. EPA, Durham, NC
and 2Biochemistry, North Carolina State University,
Raleigh, NC.
177
#1482
THE MOLECULAR BASIS OF
DIFFERENTIAL SENSITIVITY OF
COCKROACH VOLTAGE-SENSITIVE
SODIUM CHANNELS TO INHIBITION BY
INDOXACARB. K. Silver, Y. Nomura and K.
Dong. Entomology, Michigan State University, East
Lansing, MI.
#1483
PYRETHROID INDUCED ALTERATIONS
IN TRANSCRIPTION OF CALCIUM
RESPONSIVE AND IMMEDIATE EARLY
GENES IN VIVO. J. A. Harrill1 and K. M. Crofton2,
1 1
. Curriculum in Toxicology, University of North
Carolina at Chapel Hill, Chapel Hill, NC and
2
Triangle Park, NC.
#1484
THE ROLE OF OXIDATIVE STRESS IN
THE NEUROTOXICITY OF MANCOZEB
AND MANEB. L. M. Domico1, G. D. Zeevalk2, B.
Buckley3, B. Winnik3, M. J. Thiruchelvam1 and K.
R. Cooper1. 1Joint Graduate Program in Toxicology,
Rutgers University, Piscataway, NJ, 2Neurology,
UMDNJ, Piscataway, NJ and 3Environmental &
Occupational Health Sciences Institute, Rutgers/
UMDNJ, Piscataway, NJ.
#1485
THE PROTECTIVE EFFECT OF BHT
AGAINST MANCOZEB (MANGANESE-ZINC
ETHYLENEBIS DITHIOCARBAMATE)
INDUCED CYTOTOXICITY IN ASTROCYTES.
M. Tsang and L. D. Trombetta. Pharmaceutical
Sciences, St. John’s University, Jamaica, NY.
#1486
EFFECTS ON STRIATAL
NEUROCHEMISTRY OF CHRONIC
ATRAZINE EXPOSURE INTERPHASED
WITH SHORT-TERM EXPOSURE TO
MANEB. N. M. Filipov, A. B. Norwood, A.
Coban and S. C. Sistrunk. CEHS, Basic Sciences,
Mississippi State University, Mississippi State, MS.
#1487
CHRONIC EXPOSURE TO ATRAZINE
MODULATES THE DOPAMINERGIC
TOXICITY OF MPTP. A. B. Norwood, A. Coban,
S. C. Sistrunk and N. M. Filipov. CEHS, Basic
State, MS.
#1488
MECHANISMS OF ATRAZINE’S EFFECTS
ON BRAIN MONOAMINE FUNCTION. V. M.
Rodriguez, M. Thiruchelvam, J. K. Kochar and D.
A. Cory-Slechta. Environmental and Community
Medicine, Environmental and Occupational Health
Sciences Institute, The University of Medicine and
Dentistry of New Jersey and Rutgers, Piscataway,
NJ.
#1489
INCREASE OF DOPAMINE AND 5-HT
LEVELS AFTER AMITRAZ TREATMENT.
M. A. Martinez, J. Del Pino, M. Marta, M. J.
Diaz, V. Caballero, M. R. Martinez-Larranaga
and A. Anadon. Department of Toxicology and
Pharmacology, Complutense University, Madrid,
Spain.
TUESDAY
45th Annual
Meeting & ToxExpo
Tuesday Evening
FIPRONIL AND PICROTOXININ BLOCK
GABAA RECEPTORS BY DIFFERENTIAL
MECHANISMS. X. Zhao, J. Z. Yeh and T.
Narahashi. Molecular Pharmacology and Biological
Chemistry, Northwestern University, Chicago, IL.
#1490
COMPARISON OF NICOTINIC
ANTAGONISTS IN BLOCKING THE EFFECT
OF ANATOXIN-A AND NICOTINE ON THE
MOTOR ACTIVITY OF RATS. R. C. MacPhail,
J. D. Farmer and K. A. Jarema. NHEERL, U.S. EPA,
#1491
Tuesday, March 7
6:00 PM to 7:30 PM
See Events Calendar on page 2–6 for Room Listings
SPECIALTY SECTION MEETINGS/RECEPTIONS: FOOD
SAFETY, IN VITRO, METALS, MOLECULAR BIOLOGY,
REPRODUCTIVE AND DEVELOPMENTAL, TOXICOLOGIC
AND EXPLORATORY PATHOLOGY, WOMEN IN TOXICOLOGY
Tuesday, March 7
2:45 PM to 3:45 PM
Room 11A
Tuesday, March 7
6:00 PM to 7:30 PM
See Events Calendar on page 2–6 for Room Listings
INFORMATIONAL SESSION: APPLICATIONS OF GENECHIP®
TECHNOLOGY FOR TOXICOGENOMICS—PART TWO
REGIONAL CHAPTER MEETINGS/RECEPTIONS
Presented by Affymetrix
Customers will describe the use of GeneChip® microarray technology in
their toxicological research. Affymetrix offers both RNA and DNA products on a single platform in multiple formats. Automation tools enable
standardization and labor cost reduction. Find out how leading-edge scientists are streamlining and powering up their toxicogenomic workflow with
Affymetrix.
Many of the Regional Chapters meet during the SOT Annual Meeting.
Details for these Regional Chapter receptions and meetings are listed in the
Events Calendar.
Tuesday, March 7
6:00 PM to 8:30 PM
Marina Ballroom D
AFRICAN SOCIETY OF TOXICOLOGICAL SCIENCES
Tuesday, March 7
2:45 PM to 3:45 PM
Room 11B
Tuesday, March 7
6:00 PM to 7:30 PM
Room 10
INFORMATIONAL SESSION: EXPERT SERVICES AND CUSTOM
SOLUTIONS
WOMEN IN TOXICOLOGY SPECIALTY SECTION MEETING/
RECEPTION
Presented by Dow Corning
Are you challenged by materials that are difficult to test? Need a laboratory
that can develop and validate methods? Or do you need regulatory compliance reviews for materials? Come find out how Dow Corning EH&S
experts and services can help keep your business moving forward.
TUESDAY
Tuesday, March 7
4:30 PM to 6:00 PM
Room 5B
Women in Toxicology Members and friends are cordially invited to a
reception and talk with special guest speaker Joanne DeRitis ”Communicating with Confidence.” Joanne is a Senior Training Consultant for
Novations Group Inc, and has provided training and personalized coaching
to executives, leaders, sales teams, and technical professionals across the
United States, Europe, and Asia. Ms. DeRitis will show you how confident
communicators connect with their audience and get results. Learn the three
most impactful skills that lead to openness, acceptance, and action. Identify
and minimize the common mistakes that can hold you back.
SOT ANNUAL BUSINESS MEETING
Chairperson(s): Kendall Wallace, SOT President
SOT Members Only.
Members are invited and encouraged to attend the 45th Annual SOT
Business Meeting. If you have long-range planning ideas that you would
like added to the agenda, please send them to Shawn Lamb at SOT Headquarters. The agenda includes a discussion of the Council 2006 strategic
planning session, financial summary, a review of the 2005–2006 activities,
and plans for the future.
178
45th Annual
Meeting & ToxExpo
Wednesday Morning
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 6B
Wednesday, March 8
8:00 AM to 8:50 AM
Room 6A
SYMPOSIUM SESSION: GENE-NUTRIENT-ENVIRONMENTINTERACTIONS AS RISK FACTORS FOR BIRTH DEFECTS:
FUMONISIN, FOLATE, GENETIC VARIATION AND NEURAL
TUBE DEFECTS
SOT/EUROTOX DEBATE: ‘OMICS’ RESEARCH DOES NOT
ADD SUBSTANTIALLY TO THE SAFETY ASSESSMENT OF
CHEMICALS
Chairperson(s): Janee Gelineau-van Waes, University of Nebraska
Medical Center, Omaha, NE and Ronald Riley, USDA, Athens, GA.
Motion: ‘Omics’ Research Does Not Add Substantially to the Safety
Assessment of Chemicals
Endorsed by:
Food Safety SS*
Mechanisms SS
Reproductive and Developmental Toxicology SS
Debaters:
(Pro) EUROTOX: Alan Boobis, Imperial College London, London, United
Kingdom.
(Con) SOT: Dan Nebert, University of Cincinnati, Cincinnati, OH.
The 2006 Eurotox debate continues a very informative series in which
the points and respective counterpoints on a given topic are addressed by
well known toxicologists. Dr. Daniel W. Nebert and Prof. Alan R. Boobis
will present differing views on the contribution of ‘omic’ technologies for
assessing chemical safety as it applies to assessing human risk.
Wednesday, March 8
8:30 AM to 9:30 AM
Room 11B
INFORMATIONAL SESSION: CARDIAC SAFETY—CURRENT
THINKING WHEN APPROACHING SAFETY ASSESSMENT
STUDIES
Presented by Covance
Adverse effects on cardiac safety have been responsible for several highprofile withdrawals, denied regulatory approvals and adverse labeling in
human pharmaceuticals in recent years. This session will present current
thinking on the electrophysiology of drug-induced QT prolongation, and a
rational approach to the pre-clinical assessment of drugs for their potential
to produce this unwanted, and potentially dangerous, side effect.
The second most common birth defect is neural tube defects (NTDs). In
Guatemala, parts of China and Africa, NTD risk is estimated to be higher
than that observed in the USA. The etiology of NTD in these areas is
complex. Increased risk has been associated with genetic predisposition,
dietary exposure to environmental contaminants, and reduced intake of
folate and other vitamins/nutrients. Human clinical and epidemiological
studies show folate supplementation reduces the risk for NTDs. Fumonisins are carcinogenic mycotoxins that cause farm animal diseases. They
commonly contaminate maize and are suspected, but not proven, to cause
human disease. Their mode of action involves inhibition of the enzyme
(ceramide synthase) that controls the formation of sphingolipids; important
regulators of pathways involved in cell death and survival. Sphingolipids
are needed for the proper function of receptors associated with lipid rafts;
for example, the folate-binding protein (Folbp1). Fumonisin disruption of
folate transport via Folbp1 interferes with neural tube closure in animal
models in vitro and can be prevented by folate supplementation. In vivo
studies in LM/Bc and CD1 mouse strains have found that maternal fumonisin administration during pregnancy increases the frequency of NTD
in exposed embryos. Supplementation with folate or ganglioside GM1 is
protective, suggesting altered sphingolipid-dependent lipid raft function. In
addition, altered expression of cytokines, inducible nitric oxide synthase,
and several genes involved in redox homeostasis are observed in affected
embryos. While there is no direct evidence for fumonisin as a cause of
NTD in humans, the incidence of NTD is higher where maize consumption
is high and both fumonisin exposure and folate deficient diets are likely.
Epidemiological studies and further experimentation with animal models
will be necessary to assess the teratogenic potential and impact of fumonisin as a human health hazard.
#1492
9:00
GENE-NUTRIENT-ENVIRONMENT
INTERACTIONS AS RISK FACTORS FOR
BIRTH DEFECTS: FUMONISIN, FOLATE,
GENETIC VARIATION AND NEURAL TUBE
DEFECTS. J. Gelineau-van Waes1 and R. T. Riley2.
1
Center for Human Molecular Genetics, Nebraska
Medical Center, Omaha, NE and 2Toxicology and
Mycotoxin Research Unit, USDA-ARS-SAA,
Athens, GA.
#1493
9:10
THE RELATIONSHIP BETWEEN FOLATE
DEFICIENCY, MAIZE CONSUMPTION,
FUMONISIN INTAKE, AND GENETIC
FACTORS ON NTD INCIDENCE
WORLDWIDE. M. Speer, A. Wise, J. R. Gilbert
and J. Freedman. Duke University Medical Center,
Durham, NC. Sponsor: J. Gelineau-van Waes.
Wednesday, March 8
8:30 AM to 9:30 AM
Room 11A
INFORMATIONAL SESSION: MORPHOLINO ANTISENSE
OLIGOS FOR BLOCKING TRANSLATION AND MODIFYING
SPLICING
Presented by Gene Tools
Morpholino antisense oligos knockdown genes by halting the initiation complex, preventing translation. Morpholinos can block pre-mRNA
splicing, producing messengers with introns included or exons missing.
We will compare Morpholinos with other antisense (including siRNA),
explain their mechanism of action, discuss delivery to the cytosol and show
examples of their use.
179
WEDNESDAY
Endorsed by:
Society of Toxicology (SOT)
European Societies of Toxicology (EUROTOX)
45th Annual
Meeting & ToxExpo
#1494
#1495
#1496
9:50
10:30
11:10
FUMONISIN DISRUPTION OF
SPHINGOLIPID METABOLISM AND ITS
IMPLICATIONS IN HUMAN AND ANIMAL
DISEASE. K. A. Voss and R. T. Riley. Toxicology
and Mycotoxin Research Unit, USDA-ARS-SAA,
Athens, GA.
#1498
9:10
PATHOGENESIS OF OCCUPATIONAL
ASTHMA. D. I. Bernstein. Division of
Immunology-Allergy, University of Cincinnati,
Cincinnati, OH. Sponsor: J. Regal.
#1499
9:40
FUMONISIN B1-INDUCED INHIBITION OF
FOLATE RECEPTOR-MEDIATED VITAMIN
UPTAKE. V. L. Stevens. Epidemiology and
Surveillance Research, American Cancer Society,
Atlanta, GA. Sponsor: R. Riley.
USING MURINE MODELS TO UNDERSTAND
THE IMMUNOLOGIC BASIS OF TOLUENE
DIISOCYANATE ASTHMA. V. J. Johnson and
M. I. Luster. Toxicology and Molecular Biology
Branch, NIOSH/CDC, Morgantown, WV.
#1500
10:10
DIFFERENTIAL GENE EXPRESSION AND
EFFECTOR MECHANISMS IN MURINE
MODELS OF TRIMELLITIC ANHYDRIDE
AND OVALBUMIN-INDUCED ASTHMA. J.
F. Regal1, A. L. Greene1, M. Rutherford3, R. R.
Regal2, C. Giulivi4, M. Mohrman1, G. Flickinger3
and J. Hendrickson3. 1Biochemistry & Molecular
Biology, University of Minnesota Medical School
Duluth, Duluth, MN, 2Mathematics & Statistics,
University of Minnesota, Duluth, MN, 3Veterinary &
Biomedical Sciences, University of Minnesota, St.
Paul, MN and 4Molecular Biosciences, University of
California-Davis, Davis, CA.
#1501
10:40
THE ROLE OF OXIDATIVE STRESS IN
THE EXACERBATION OF ASTHMA BY
PARTICULATE AIR POLLUTION. A. E. Nel.
Medicine, UCLA, Los Angeles, CA. Sponsor: J.
Regal.
#1502
11:10
GENETIC SUSCEPTIBILITY AND OZONE
EXACERBATION OF ALLERGIC ASTHMA. S.
R. Kleeberger. Laboratory of Respiratory Biology,
NIH/NIEHS, Research Triangle Park, NC.
MATERNAL FUMONISIN EXPOSURE AND
NEURAL TUBE DEFECTS: MECHANISMS
IN A MOUSE MODEL. J. B. Gelineau-van Waes1,
J. Maddox1, J. Wilberding1, L. Bauer1, K. Voss2
and R. Riley2. 1Genetics, Cell Biology & Anatomy,
Nebraska Medical Center, Omaha, NE and 2USDAARS Toxicology & Mycotoxin Research Unit,
Athens, GA.
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 6F
SYMPOSIUM SESSION: MODELS AND MECHANISMS OF
OCCUPATIONAL/ENVIRONMENTAL ASTHMA
Chairperson(s): Jean Regal, University of Minnesota, Duluth, MN and
Michael Luster, CDC-NIOSH, Morgantown, WV.
Endorsed by:
Inhalation SS
Occupational asthma is defined as variable airflow limitation and bronchial
hyperresponsiveness due to causes and conditions encountered in a workplace environment. A myriad of substances are responsible for occupational
asthma, including low molecular weight chemicals and protein allergens.
Though asthma is treated as a single lung disorder, it is increasingly clear
that the pathophysiology of asthma may differ substantially depending on
the allergen, exposure conditions and environmental triggers. Diagnostic,
immunologic and genetic factors associated with disease development are
being actively investigated. Animal models for occupational asthma are
being developed to define mechanisms of this lung disorder and determine
more effective methods for prevention, diagnosis and treatment of occupational asthma. Both toluene diisocyanate and trimellitic anhydride are
prototype low molecular weight chemicals that cause asthma in the workplace, and studies defining the effector mechanisms for these allergens are
being investigated. Environmental factors such as ozone and particulate
air pollution can exacerbate existing asthma and profoundly influence the
pathophysiology and clinical outcome. Understanding the interactions of
environmental and genetic factors is also important to define potential
populations at risk. Continued studies in the workplace and in animal
models are needed to more clearly diagnose, define the pathophysiology
and triggers, and effectively treat this important public health problem.
WEDNESDAY
#1497
9:00
MODELS AND MECHANISMS OF
OCCUPATIONAL/ENVIRONMENTAL
ASTHMA. M. I. Luster1 and J. F. Regal2.
1
Toxicology & Molecular Biology Branch, NIOSH,
Morgantown, WV and 2Biochemistry & Molecular
Biology, University of Minnesota Medical School
Duluth, Duluth, MN.
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 6C
SYMPOSIUM SESSION: OBESITY AS A MODULATOR OF
CHEMICAL TOXICITY
Chairperson(s): Chris Corton, U.S. EPA, Chapel Hill, NC.
Endorsed by:
Mechanisms SS*
Obesity as a Modulator of Chemical Toxicity In the last few decades
the overweight and obese in the US have grown from a relatively minor
subpopulation to ~60% of all adults. Even more alarming is the dramatic
increase in the number of overweight and obese children. This obesity
epidemic is linked to increases in the incidences in cardiovascular disease,
diabetes mellitus and certain forms of cancer. Adipose tissue is no longer
considered a static depot of excess energy reserves but an endocrineactive tissue. Increases in adipose tissue, particularly abdominal fat lead
to features of insulin resistance syndrome, also referred to as metabolic
syndrome X. This syndrome consists of a clustering of metabolic abnormalities that increase the risk for type 2 diabetes and cardiovascular
disease. Adipose tissue also secretes a number of cytokines leading to a
low inflammatory state in the obese. Additionally, obesity is associated
with higher levels of insulin, insulin-like growth factor I and oxidative
stress that are mechanistically linked to carcinogenesis. Given that chemical toxicity is often dependent on the same factors that are at increased
levels in the obese, obesity may lead to an environment of increased sensitivity to chemical-induced toxicity. In this symposium, the physiological,
biochemical and molecular mechanisms that lead to metabolic syndrome X
and changes in growth factors and cytokine secretion in the obese will be
180
45th Annual
Meeting & ToxExpo
#1503
9:00
OBESITY AS A MODULATOR OF CHEMICAL
TOXICITY. J. C. Corton. NHEERL, U.S. EPA,
#1504
9:05
OBESITY AS A MODIFIER OF CHEMICAL
TOXICITY - HISTORICAL PERSPECTIVE.
G. Corcoran1 and C. Corton2. 1Department of
Detroit, MI and 2NHEERL, U.S. EPA, Research
Triangle Park, NC.
#1505
#1506
#1507
#1508
9:40
10:15
10:50
11:25
two talks will address activation of MAPKs in response to metal exposure
irrespective of changes in redox state, as observed with Zn and Cr(VI) in
human airway epithelium. Zn induces activation of ERK1/2, JNK and p38
and the tyrosine kinase receptor, EGFR. Modulation of ERK1/2 and EGFR
involves multiple levels of activation, including EGFR transactivation by
Src and metalloprotease activation. Finally, other studies on airway epithelium have examined signaling pathways by which Cr(VI), at non-cytotoxic
concentrations, selectively induces and silences genes. Cr stimulates Src
family kinases (SFK) Lck and Fyn, but not Src or Yes, and stimulation of
SFKs leads to selective activation of JNK. However, although Cr induces
ROS generation, SFK-dependent JNK activation occurs independent of
metal-induced oxidative stress.
OBESITY, METABOLIC SYNDROME X AND
INFLAMMATION. P. Dandona. SUNY-Buffalo,
Buffalo, NY. Sponsor: C. Corton.
DIET-INDUCED DIABETES AS A
MODULATOR OF CHEMICAL TOXICITY
IN THE LIVER. H. Mehendale. Department of
Toxicology, University of Louisiana, Monroe, LA.
OBESITY AND INCREASED
SUSCEPTIBILITY TO CHEMICALLYINDUCED NEURODEGENERATION. J.
O’Callaghan. CDC-NIOSH, Morgantown, WV.
DIET, OBESITY AND CHEMICAL
CARCINOGENESIS: EXPERIMENTAL
APPROACHES. S. Hursting. NCI, Rockville, MD.
Sponsor: C. Corton.
#1509
9:00
THE ROLE OF MAP KINASES IN METAL
TOXICITY. A. R. Villalobos. Environmental
Medicine, University of Rochester, Rochester, NY.
#1510
9:05
MAP KINASE SIGNALING CASCADES. M.
H. Cobb. Pharmacology, The University of Texas
Southwestern Medical Center at Dallas, Dallas, TX.
Sponsor: A. Villalobos.
#1511
9:40
MAP KINASE ACTIVATION AND METALS:
ALTERED REDOX STATE OR ENZYME
MODIFICATION? H. J. Forman. UC Merced,
Merced, CA. Sponsor: A. Villalobos.
#1512
10:15
METAL-INDUCED OXIDATIVE STRESS AND
CELLULAR RESPONSES. X. Shi. NIOSH,
Morgantown, WV. Sponsor: A. Villalobos.
#1513
10:50
ZN2+-INDUCED MAPK AND EGFR
ACTIVATION IN HUMAN AIRWAY
EPITHELIAL CELLS (HAEC) ARE
MEDIATED BY PHOSPHATASE INHIBITION.
J. M. Samet1, 3, Y. Kim2, T. Tal3, P. Bromberg2,
W. Wu2 and L. M. Graves2, 3. 1Human Studies
Division, U.S. EPA, Chapel Hill, NC, 2Center
for Environmental Medicine and Lung Biology,
University of North Carolina, Chapel Hill, NC and
3
Curriculum in Toxicology, University of North
Carolina, Chapel Hill, NC. Sponsor: A. Villalobos.
#1514
11:25
JNK ACTIVATION BY CHROMIUM IN
THE LUNG. A. Barchowsky. Department of
of Pittsburgh Graduate School of Public Health,
Pittsburgh, PA.
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 7B
SYMPOSIUM SESSION: THE ROLE OF MAP KINASES IN
METAL TOXICITY
Chairperson(s): Alice Villalobos, University of Rochester, Rochester, NY
and Aaron Barchowsky, University of Pittsburgh, Graduate School of
Public Health, Pittsburgh, PA.
Endorsed by:
Inhalation SS
Mechanisms SS
Metals SS*
Mitogen-activated protein kinases (MAPKs) may mediate the cytotoxic
responses and cytoprotective mechanisms elicited by metals, such as Zn,
Cd, Cr, and As. The session will open with a review of the common and
unique biochemical properties of MAPK family members, ERK1/2, ERK5,
JNKs, and p38 proteins, activation of each MAPK cascade by selective
stimuli, and the respective down stream targets in the context of their
physiological function. A common cellular response to exposure to various
metals is an altered redox state. The second talk will address direct activation of MAPKs by oxidants, such as hydrogen peroxide, and electrophiles,
such as 4-hydroxy-2-nonenal (HNE), an end product of lipid peroxidation.
A highlighted example of MAPKs as mediators of cytoprotective mechanisms recruited in response to oxidative stress will be HNE-induction of
g-glutamyl transpeptidase via ERK1/2 and p38 and of glutamate-cysteine
ligase via JNK, two responses critical to adaptive increases in GSH. The
third talk will address MAPKs as mediators of cytotoxic responses triggered specifically by metal-induced oxidative stress. For example, Cr(VI)
at toxic concentrations, via ERK1/2 and p38, upregulates p21 and cdc2 and
causes degradation of cdc25C, leading to growth arrest at G2/M. The last
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 15A
WORKSHOP SESSION: ADVANCED TECHNOLOGIES
AND APPROACHES FOR QUANTITATIVE BIOLOGICAL
MONITORING AND MODELING FOR CHEMICAL EXPOSURES
Chairperson(s): Charles Timchalk, Pacific Northwest National Laboratory,
Richland, WA and Karla Thrall, Battelle Pacific Northwest Laboratories,
Richland, WA.
Endorsed by:
There is a need to develop sensitive and novel approaches that can be used
for biological monitoring of both occupational and environmental exposures to a broad-range of chemical agents, and to rapidly determine the
potential implications of these exposures to human health. This symposium
181
WEDNESDAY
discussed. A number of examples in rodent models will be given, in which
obesity clearly alters chemical toxicity in a number of tissues. The information presented in this symposium will highlight the fact that the obese
should be evaluated as a sensitive population.
45th Annual
Meeting & ToxExpo
will highlight technology that focuses on the application of bio-analytical
chemistry for assessing low level chemical exposure, coupled to the
development of sensitive, selective, rapid, and cost-effective sensors for
toxicity screening, biomonitoring, and development of field deployable
platforms. These approaches can be applied to identify novel biomarkers in
experimental animal model systems and in humans using a range of readily
obtainable biological matrices. Finally, through the application of advanced
computational modeling it may be possible to quantitatively determine
dosimetry. The first speaker will focus on approaches for quantifying
biomarkers of low-level chemical exposures in biological samples obtained
from epidemiology studies using mass spectrometry isotope dilution. The
second and third speakers will highlight ongoing research focused on the
development of cost-effective toxicity screening methods, and the application of immunoassay based biosensor platforms for biomonitoring. The
final two speakers will highlight the potential application of these high
resolution analytical approaches and sensor technologies to assess chemical exposures in real-time through the direct analysis of exhaled breath
or saliva for a range of agents including organic solvents, heavy metals,
insecticides, and the application of physiologically based pharmacokinetic
models to assess total exposure and internal target tissue dosimetry. The
presentations in this symposium will provide important insight on the value
of integrating quantitative sensor technology with traditional biological
monitoring approaches to advance our capabilities for chemical exposure
biological monitoring and modeling.
#1515
9:00
ADVANCED TECHNOLOGIES AND
APPROACHES FOR QUANTITATIVE
BIOMONITORING FOR CHEMICAL
EXPOSURES. C. Timchalk and T. Karla. Pacific
#1516
9:10
A COMPREHENSIVE BIOMONITORING
APPROACH TO ASSESS EXPOSURES TO
NONPERSISTENT ORGANIC TOXICANT
APPLICATION TO GENERAL EXPOSURE
AND HEALTH EFFECTS STUDIES. D. B.
Barr. NCEH/DLS, CDC, Atlanta, GA. Sponsor: C.
Timchalk.
#1517
9:45
SCREENING HAZARDOUS INDUSTRIAL
CHEMICALS FOR TOXICITY AND
GENOTOXICITY. K. R. Rogers and S. Kailasam.
NERL-LV, U.S. EPA, Las Vegas, NV. Sponsor: C.
Timchalk.
#1518
10:20
APPLICATION OF IMMUNOASSAYS
IN HUMAN AND ENVIRONMENTAL
MONITORING. B. D. Hammock, K. Ahn, S.
J. Gee, A. Gonzalez, H. Kim, M. Koivunen, M.
Nichkova-Dosev, E. Park and D. Stoutamire.
University of Californai, Davis, CA.
#1519
10:55
BIOLOGICAL MONITORING USING A
COMBINATION OF EXHALED BREATH
ANALYSIS AND PBPK MODELING. K. D.
Thrall. Battelle, Pacific Northwest Division,
Richland, WA.
#1520
11:30
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 6E
WORKSHOP SESSION: THERMOREGULATION AND ITS
INFLUENCE ON TOXICITY ASSESSMENT
Chairperson(s): Jon Hotchkiss, The Dow Chemical Company, Midland, MI
and Christopher Gordon, U.S. Environmental Protection Agency, Research
Triangle Park, NC.
Endorsed by:
Carcinogenesis SS
Inhalation SS
Neurotoxicology SS
Risk Assessment SS*
Temperature is a fundamental factor influencing all aspects of biological
systems. Perhaps because of its simplicity and ubiquitous nature, changes
in body temperature are often overlooked, or minimized, when assessing
the toxicity of chemicals, air pollutants, toxins and pharmacologic agents.
Rodents in particular can respond to acute xenobiotic exposure with a
regulated reduction in core body temperature (hypothermia) which can
have a major impact on physiological and biochemical processes of the
organism. This acute response is generally beneficial to the animal because
supportive measures to prevent the drop in core body temperature can
decrease survival. The impact of toxicant-induced hypothermia is not
limited to acute toxicologic endpoints. Micronucleus formation is routinely
used to establish the potential mutagenicity of a test material. However,
hypothermia alone can increase micronucleus formation, confounding the
interpretation of the mutagenic activity attributed directly to the toxicant
from that of the toxicant-induced adaptive hypothermic response. While
hypothermia is the predominant thermoregulatory response to toxicantexposure in rodents, hyperthermia is a frequent observation in humans
following acute exposure to a variety of toxicants. Because humans do
not respond similarly to exposure to toxic agents data extrapolation can
be confounded, increasing the uncertainty of the risk assessment process.
Given the complexity and divergence of these physiologic responses,
toxicity data derived from exposures in rodents should be considered in
the context of any chemical-induced effects on thermoregulation in order
to improve predictions of potential human toxicity. This workshop should
be of interest to experimental toxicologists in all disciplines, as well as
individuals involved with pharmaceutical development, human risk assessment, and product regulation and registration.
WEDNESDAY
NON-INVASIVE BIOMONITORING
APPROACHES TO DETERMINE DOSIMETRY
AND RISK FOLLOWING CHEMICAL
EXPOSURE: ANALYSIS OF LEAD AND
ORGANOPHOSPHATE INSECTICIDE IN
SALIVA. C. Timchalk, W. Yantasee, G. Liu and Y.
Lin. Battelle, Pacific Northwest Division, Richland,
WA.
182
#1521
9:00
THERMOREGULATION AND ITS
INFLUENCE ON TOXICITY ASSESSMENT.
J. A. Hotchkiss1 and C. J. Gordon2. 1Toxicology and
Environmental Research and Consulting (TERC),
The Dow Chemical Company, Midland, MI and
2
Triangle Park, NC.
#1522
9:05
INTEGRATED THERMOREGULATORY
RESPONSES TO TOXICANTS. C. J. Gordon.
Triangle Park, NC. Sponsor: J. Hotchkiss.
#1523
9:40
BODY TEMPERATURE CHANGES
IN RODENT INHALATION STUDIES:
INDICATOR OF ADVERSE EFFECT OR
RODENT-SPECIFIC ADAPTIVE RESPONSE?
J. Pauluhn. Toxicology Section of Inhalation, Bayer
Healthcare AG, Wuppertal, Germany.
45th Annual
Meeting & ToxExpo
10:15
THERMOREGULATION: A KEY VARIABLE
FOR INTERPRETING RESULTS FROM THE
MOUSE MICRONUCLEUS TEST. P. J. Spencer,
J. M. Grundy, J. M. Waechter and B. Gollapudi.
Toxicology & Environmental Research and
Consulting, The Dow Chemical Company, Midland,
MI.
#1525
10:50
TEMPERATURE AND NEUROTOXICITY
- LESSONS FROM THE AMPHETAMINES. D.
B. Miller. Toxicology & Molecular Biology Branch,
CDC-NIOSH, Morgantown, WV.
#1526
11:25
#1531
10:20
NALTREXONE HYDROCHLORIDE: A
CARDIOVASCULAR TELEMETRY STUDY
IN THE UNRESTRAINED NAÏVE MALE
CYNOMOLGUS MONKEY. J. C. Tigner1, H.
Penton2, H. Ibrahim1 and N. Leblond2. 1Purdue
Pharma, Ardsley, NY and 2Toxicology, Charles River
Canada.
#1532
10:40
EVALUATION OF THE USE OF TIMESYNCHRONIZED VIDEO RECORDING IN
DRUG SAFETY ASSESSMENT: APPLICATION
TO QT PROLONGATION STUDIES. E. L.
Bijaoui, V. Benadava, P. Hua, D. Dreptate, S.
Lascu, Y. Del Sindaco, V. Ripoll, O. Cochelin, M.
Lemanissier, J. Darche, H. Moutot and P. Zitoun.
NOTOCORD Systems, Croissy sur Seine, France.
Sponsor: L. Kinter.
#1533
11:00
APPLICATION OF A NON-INVASIVE
TELEMETRY SYSTEM FOR
ELECTROCARDIOGRAM ASSESSMENT IN
A DOG TOXICOLOGY STUDY. J. Schofield,
N. McMahon, M. Coulson, T. Hammond and J.
Valentin. Safety Assessment, AstraZeneca R&D,
Macclesfield, United Kingdom.
#1534
11:20
ASSESSMENT OF THE IMPACT OF
CARDIOTOXICITY DIAGNOSIS BY
TROPONIN AND GENOMICS MEASURES.
R. Dunn, P. Nordone, S. Thukral, L. Healy, E.
Galambos, P. Sabitsana, A. Fosdick, J. Urgino,
R. Hu, M. Cosenza and C. Afshari. Comparative
Biology and Safety Sciences, Amgen, Thousand
Oaks, CA.
#1535
11:40
ZEBRAFISH: A PREDICTIVE MODEL FOR
ASSESSING CARDIOTOXICITY OF DRUG
CANDIDATES. C. Ton, C. Willett, N. Roy, Y. Lin,
C. Parng and P. McGrath. Phylonix Pharmaceuticals,
Inc., Cambridge, MA. Sponsor: L. Costa.
IMPACT OF THERMOREGULATION ON
PHARMACOKINETIC PARAMETERS AND
IMPLICATIONS FOR HUMAN TOXICITY
ASSESSMENT. P. M. Hinderliter and R. A. Corley.
Biological Monitoring and Modeling, Pacific
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 2
PLATFORM SESSION: CARDIOVASCULAR SAFETY
ASSESSMENT
Chairperson(s): Betty Ann Petterson, Pfizer Global Research &
Development, Groton, CT and Lewis Kinter, AstraZeneca Pharmaceuticals
LP, Wilmington, DE.
#1527
#1528
#1529
#1530
9:00
9:20
9:40
10:00
THE RAT H9C2 EMBRYONIC VENTRICULAR
MYOCYTE CELL LINE: AN IN VITRO
MODEL FOR EXAMINING STRIATED
MUSCLE TOXICITY. G. H. Searfoss, B. W.
Halstead, R. A. Jolly, T. K. Baker, H. Gao, M. A.
Higgins and T. P. Ryan. Investigative Toxicology,
Lilly Research laboratories, Greenfield, IN. Sponsor:
C. Thomas.
INTERPRETATION OF QT INTERVAL USING
HEART RATE CORRECTION FORMULA IN
PRE-CLINICAL TOXICOLOGY STUDIES.
D. Dandekar, L. P. Sheets, S. Ensley, K. Willard,
J. Applegate, D. Phipps, P. McKinney, J. Stroup,
S. Fontana and W. Bomann. Bayer CropScience,
Stilwell, KS, KS.
USE OF A FAILING RABBIT HEART AS A
MODEL TO PREDICT TORSADOGENICITY.
A. Kijtawornrat1, Y. Nishijima1, 2, B. Roche2,
B. Keene2, 3 and R. Hamlin1, 2. 1Department of
Veterinary Biosciences, The Ohio State University,
Columbus, OH, 2QTest Labs, Inc., Columbus, OH
and 3Department of Veterinary Clinical Sciences,
North Carolina State University, Raleigh, NC.
Sponsor: M. Hejtmancik.
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 1B
PLATFORM SESSION: DIOXINS, PCBS AND PBDES
Chairperson(s): Linda Birnbaum, U.S. EPA, Research Triangle Park, NC
and Dennis Paustenbach, ChemRisk Inc., San Francisco, CA.
RELIABILITY OF TELEMETRY IN
COMMON MARMOSETS FOR EVALUATION
OF DRUG-INDUCED QT INTERVAL
PROLONGATION. T. Hara, S. Sone, N.
Shishido, S. Kuramoto, K. Nakano, H. Onodera,
M. Tabo, K. Kimura and K. Kobayashi. CHUGAI
Pharmaceutical Co., Ltd., Kamakura shi, Kanagawa,
Japan. Sponsor: T. Sugimoto.
183
#1536
9:00
DIOXIN AND DIABETES: DOES THE
CURRENT WEIGHT OF EVIDENCE
DEMONSTRATE A RELATIONSHIP? M.
Gough3, D. J. Paustenbach4, B. D. Kerger1, H.
Leung2, P. Scott6 and M. Harris5. 1HSRI, Inc.,
Tallahassee, FL, 2Consultant, Danbury, CT,
3
Consultant, Bethesda, MD, 4ChemRisk, San
Francisco, CA, 5ChemRisk, Houston, TX and
6
ChemRisk, Pittsburgh, PA.
#1537
9:20
ALTERATION IN CARCINOGENIC
POTENCY OF PCB126 BY PCB153
FOLLOWING CHRONIC EXPOSURE IN
FEMALE RATS. N. J. Walker1, M. E. Wyde1, M.
Easterling2, A. Nyska1, C. R. Portier1 and J. R.
Bucher1. 1Environmental Toxicology Program,
NIEHS, Research Triangle Park, NC and 2Constella
Group, Research Triangle Park, NC.
WEDNESDAY
#1524
45th Annual
Meeting & ToxExpo
#1538
9:40
RELATIVE CARCINOGENIC POTENCY
OF PCB 126 AND PECDF IN DERMALLY
EXPOSED FEMALE TG.AC MICE. M. E.
Wyde1, A. Nyska1, M. Vallant1, L. M. Fomby2, M.
Hejtmancik2, M. Easterling3, J. R. Bucher1 and N.
J. Walker1. 1NIEHS, Research Triangle Park, NC,
2
Battelle, Columbus, OH and 3Constella Group,
#1539
10:00
DISRUPTION OF SALT-HANDLING IN
THE DEVELOPING MOUSE KIDNEY
AS A POSSIBLE CAUSE OF 2, 3, 7,
8-TETRACHLORODIBENZO-P-DIOXININDCUD HYDRONEPHROSIS. N. Nishimura1,
2
, J. Yonemoto1, H. Nishimura3, C. F. Vogel2, F.
Matsumura2 and C. Tohyama4. 1Nat’l Institute for
Environment Studies, Tsukuba, Ibaraki, Japan,
2
Center for Environmental Health Sciences,
University of California, Davis, Davis, CA, 3Aichi
Mizuho University, Toyota, Japan and 4Graduate
School of Medicine, University of Tokyo, Tokyo,
Japan.
#1544
PLATFORM SESSION: MALE AND FEMALE REPRODUCTIVE
SYSTEM
Chairperson(s): Kathila Rajapaksa, University of Arizona, Tucson, AZ and
Ulrike Luderer, University of California Irvine, Irvine, CA.
10:20
CHARACTERIZATION OF HUMAN
HEPATOCYTE RESPONSES TO TCDD,
PCB 126, AND AROCLOR 1254 USING DNA
MICROARRAYS. K. Illouz1, J. Silkworth1, A.
Koganti2, A. Possolo1, T. R. Sutter3, S. Goodwin3 and
S. B. Hamilton4. 1Global Research Center, General
Electric, Niskayuna, NY, 2In Vitro Technologies,
Inc., Baltimore, MD, 3Feinstone Center for Genomic
Research, University of Memphis, Memphis, TN
and 4Corporate Environmental Programs, General
Electric, Fairfield, CT.
#1541
10:40
DEVELOPMENT OF MORE APPROPRIATE
PCB AND DIOXIN RISK TEF VALUES BY
USING FRESH HUMAN AND ANIMAL
HEPATOCYTES. J. Silkworth1, A. Koganti2, K.
Illouz1, A. Possolo1, M. Zhao1 and S. B. Hamilton3.
1
Global Research Center, General Electric,
Niskayuna, NY, 2In Vitro Technologies, Inc.,
Baltimore, MD and 3Corporate Environmental
Programs, General Electric, Fairfield, CT.
11:00
EFEECTS OF POLYBROMINATED
DIPHENYL ETHERS ON PROSTATE CELL
LINES. R. Garcia Boy, L. Robertson and G.
Ludewig. Occupational and Environmental Health,
University of Iowa, Iowa City, IA.
#1543
11:20
(PBDES) ANTAGONIZE TCDD INDUCED
CYP1A1 ACTIVITY IN VARIOUS IN VITRO
SYSTEMS. A. K. Peters1, S. Nijmeijer1, B. Zhao2,
A. Bergman3, T. Sanderson1, 2, M. Denison2 and
M. van den Berg1. 1IRAS, University of Utrecht,
Utrecht, Netherlands, 2University of California
Davis, Davis, CA and 3University of Stockholm,
Stockholm, Sweden.
(PBDES) IN THE USA: ADULT AND FETAL
HUMAN TISSUE LEVELS, FOOD LEVELS,
MILK AND BLOOD PARTITIONING, AND
ENVIRONMENTAL SAMPLING. A. J. Schecter1,
O. Paepke2, K. Tung1 and J. Ryan3. 1Environmental
Sciences, University of Texas School of Public
Health, Dallas, TX, 2Eurofins ERGO Laboratory,
Hamburg, Germany and 3Health Canada, Ottawa,
ON, Canada.
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 8
#1540
#1542
11:40
WEDNESDAY
184
#1545
9:00
DI(N-BUTYL) PHTHALATE AND
DIETHYLHEXYL PHTHALATE IN
COMBINATION ALTER SEXUAL
DIFFERENTIATION IN A CUMULATIVE
MANNER AS A RESULT OF DEPRESSED
FETAL TESTOSTERONE PRODUCTION AND
INSL3 GENE EXPRESSION IN MALE RATS.
K. L. Howdeshell1, 2, J. Furr2, C. R. Lambright2, V. S.
Wilson2 and L. Gray2. 1NCSU/U.S. EPA Cooperative
Training Agreement CT826512010, North Carolina
State University, Raleigh, NC and 2Reproductive
#1546
9:20
ROLE OF CYTOCHROME P450C17α
IN DIBROMOACETIC ACID-INDUCED
TESTICULAR TOXICITY IN RATS. E. Blomme,
R. Ciurlionis, I. Milicic, T. Carr, K. Whitney, T.
Miller, J. Baranowski, J. Waring and M. Strakhova.
Abbott Labs, Abbott Park, IL.
#1547
9:40
ESTROGEN DIRECTLY ENHANCES
RECOVERY FROM RADIATION-INDUCED
SPERMATOGONIAL ARREST IN RAT
TESTES. K. Porter, G. Shetty, G. A. Shuttlesworth
and M. L. Meistrich. Experimental Radiation
Oncology, Universtiy of.T. M.D. Anderson Cancer
Center, Houston, TX.
#1548
10:00
FK506, AN INHIBITOR TO CALCINEURIN,
AMELIORATES TESTICULAR DAMAGE
DUE TO CADMIUM IN MICE. L. Martin1, H.
Chen1, H. Allayee3, X. Liao1, D. Shih2, G. Lee1,
D. Hovland4, R. Hess5, K. Carnes5, R. Cantor2, 6,
J. Lusis2 and M. Collins1. 1Molecular Toxicology,
UCLA, Los Angeles, CA, 2Human Genetics, UCLA,
Los Angeles, CA, 3USC, Los Angeles, CA, 4Amgen,
Thousand Oaks, CA, 5Veterinary Biosciences,
University of Illinois, Urbana, IL and 6Pediatrics,
UCLA, Los Angeles, CA.
45th Annual
Meeting & ToxExpo
#1549
10:20
OPPOSING EFFECTS OF GLUTATHIONE
(GSH) DEPLETION AND FOLLICLE
STIMULATING HORMONE (FSH) ON
APOPTOSIS AND REACTIVE OXYGEN
SPECIES (ROS) IN CULTURED ANTRAL
FOLLICLES. M. M. Tsai-Turton1 and Universtiy
of. Luderer2, 1. 1Community and Environmental
Medicine, University of California, Irvine, CA and
2
Medicine, University of California, Irvine, CA.
#1550
10:40
OVOTOXICITY INDUCED BY 7, 12DIMETHYLBENZ[A]ANTHRACENE IN
A B6C3F1 MOUSE OVARIAN CULTURE
SYSTEM. K. Rajapaksa1, I. Sipes2 and P. B. Hoyer1.
1
2
Pharmacology, University of Arizona, Tucson, AZ.
#1551
11:00
TEMPORAL RESPONSE OF GENE
EXPRESSION TO ACUTE EXPOSURE
TO 17 α-ETHYNYL ESTRADIOL IN THE
IMMATURE RAT UTERUS. J. M. Naciff, G.
J. Overman, S. M. Torontali, G. J. Carr, L. M.
Foertsch, Z. S. Khambatta, J. P. Tiesman and G. P.
Daston. Central Product Safety, Procter & Gamble
Company, Cincinnati, OH.
#1552
#1553
11:20
11:40
CULTURED MAMMARY EPITHELIAL
CELLS DISPLAY IMPAIRED
DIFFERENTIATION AND ENHANCED
PROLIFERATION WHEN EXPOSED TO
(AHR) AGONIST TCDD. B. Lawrence1, 2 and
B. A. Vorderstrasse1, 2. 1Pharmaceutical Sciences,
Washington State University, Pullman, WA and
2
Center for Reproductive Biology, Washington State
University, Pullman, WA.
STIMULATE THE RELEASE OF PROINFLAMMATORY CYTOKINES FROM TERM
HUMAN GESTATIONAL MEMBRANES.
K. A. Brant, N. W. Thiex and R. Loch Caruso.
Environmental Health Sciences, University of
Michigan, Ann Arbor, MI.
#1555
9:20
RELATIONSHIP BETWEEN PULMONARY
EXPOSURE TO MULTIPLE DOSES OF
SINGLE WALL CARBON NANOTUBES AND
ATHEROSCLEROSIS IN APOE-/- MOUSE
MODEL. Z. J. Li, R. Chapman, T. Hulderman,
R. Salmen, A. Shvedova, M. I. Luster and P. P.
Simeonova. HELD/TMBB, NIOSH, Morgantown,
WV.
#1556
9:40
SINGLE WALL CARBON NANOTUBES
INDUCE OXIDATIVE STRESS, ACUTE
INFLAMMATION, AND PROGRESSIVE
PULMONARY FIBROSIS. E. Kisin1, A. R.
Murray2, V. Castranova1, V. E. Kagan3 and A. A.
Shvedova1. 1PPRB, NIOSH, Morgantown, WV,
2
WVU, Morgantown, WV and 3University of
#1557
10:00
OXIDATIVE INTERACTIONS OF SINGLE
WALLED CARBON NANOTUBES WITH RAW
264.7 MACROPHAGES: ROLE OF IRON. A.
A. Shvedova1, A. I. Potapovich2, A. N. Osipov2,
Y. Y. Tyurina2, E. Kisin1, D. Schwegler-Berry1, R.
Mercer1, V. Castranova1 and V. E. Kagan2. 1PPRB,
NIOSH, Morgantown, WV and 2University of
#1558
10:20
THE CYTOTOXICITY AND CYTOTOXIC
MECHANISMS OF CERIUM OXIDE
NANOPARTICLES AGAINST LUNG CANCER
CELLS. Y. Ma1, W. Lin1, Y. Huang2, X. Zhou3
and P. Nam1. 1Department of Chemistry and
Environmental Research Center for Emerging
Contaminants, University of Missouri-Rolla,
Rolla, MO, 2Department of Biological Sciences
and Environmental Research Center for Emerging
Contaminants, University of Missouri-Rolla, Rolla,
MO and 3Pacific Northwest National Laboratory,
Ricjland, WA.
#1559
10:40
ASSESSMENT OF MANGANESE
NANOPARTICLE (MN-40NM) IN PC12 CELLS.
A. Javorina1, 3, H. Duhart2, S. F. Ali2, J. J. Schlager1
and S. M. Hussain1. 1Applied Biotechnology
Branch, Human Effectiveness Directorate, Air Force
Research Laboratory, Wright-Patterson AFB, OH,
2
Division of Neurotoxicology, National Center for
Toxicological Research, Jefferson, AR and 3Oak
Ridge Institute for Science and Education, Oak
Ridge, TN.
#1560
11:00
EFFECTS OF NANOPARTICLES ON IMMUNE
RESPONSE TO PROTEIN ANTIGEN. V. J.
Tomazic-Jezic, T. H. Umbreit and M. E. Stratmeyer.
OSEL, USFDA/CDRH, Rockville, MD.
#1561
11:20
IMPACT OF NANO- TO MICRON-SIZED
PARTICLE CHARACTERISTICS ON IN
VITRO ALUMINUM PARTICLE TOXICITY.
M. Palazuelos1, 2, G. Erdos3, D. A. Moraga3, M.
Popp3, B. M. Moudgil2, 4 and K. W. Powers2.
1
Department of Chemical Engineering, University
of Florida, Gainesville, FL, 2Particle Engineering
Research Center, University of Florida, Gainesville,
FL, 3Interdisciplinary Center for Biotechnology
Research, University of Florida, Gainesville, FL and
4
Department of Materials Science and Engineering,
University of Florida, Gainesville, FL. Sponsor: S.
Roberts.
Wednesday, March 8
9:00 AM to 12:00 NOON
Room 5A
PLATFORM SESSION: NANOPARTICLE-INDUCED TOXICITY
Chairperson(s): Lung Chi Chen, NYU School of Medicine, Tuxedo, NY.
#1554
9:00
NANO-TIO2 ANATASE PARTICLES VS.
RUTILE PARTICLES: A CYTOTOXICITY
AND INFLAMMATORY RESPONSE STUDY
WITH HUMAN DERMAL FIBROBLASTS
AND HUMAN LUNG EPITHELIAL CELLS. C.
M. Sayes1, D. B. Warheit2, K. D. Ausman1 and V. L.
Colvin1. 1Chemistry, Rice University, Houston, TX
and 2DuPont Haskell lab, DuPont, Newark, DE.
185
WEDNESDAY
45th Annual
Meeting & ToxExpo
#1562
11:40
ASSESSING THE IN VITRO TOXICITY OF
FUNCTIONALIZED AMORPHOUS SILICA
NANOPARTICLES. D. Dutta1, S. Santra2, S.
Roberts3 and B. M. Moudgil1. 1Materials Science
and Engineering and Particle Engineering Research
Center, University of Florida, Gainesville, FL,
2
Nanoscience Technology Center, Department
of Chemistry and Biomolecular Science Center,
University of Central Florida, Orlando, FL and
3
Center for Environmental and Human Toxicology
and College of Veterinary Medicine, University of
#1566
EFFECTS OF ATRAZINE ON BRAIN AND
GONAD AROMATASE ACTIVITY AND
REPRODUCTIVE PARAMETERS IN A
MARINE FISH. L. J. Mills1, R. E. Gutjahr-Gobell1,
S. C. Laws2, S. Jayaraman1 and G. E. Zaroogian1.
1
Atlantic Ecology Division, U.S. EPA, NHEERL,
Narragansett, RI and 2Reproductive Toxicology
Division, U.S. EPA, NHEERL, Research Triangle
Park, NC.
#1567
CHEMICAL STRESS FROM FUEL OIL
CAUSES ADRENAL HYPERTROPHY
WITHOUT CHANGING GLUCOCORTICOID
RELEASE. F. C. Mohr1, B. Lasley2 and S. Bursian3.
1
Vet. Med.: Pathol., Microbiol. and Immunol.,
University of California, Davis, CA, 2Vet. Med.:
Pop. Health and Reproduction, University of
California, Davis, CA and 3Department of Animal
Sciences., Michigan State University, East Lansing,
MI.
#1568
ANDROGEN AGONISTS EFFECTS ON
ESTROGEN-RESPONSIVE PLASMA
PEPTIDE EXPRESSION IN THE
SHEEPSHEAD MINNOW. M. J. Hemmer, K. A.
Salinas, P. S. Harris, J. Watts, L. L. Dobbins and C.
C. Walker. U.S. EPA, ORD, NHEERL, GED, Gulf
Breeze, FL. Sponsor: W. Benson.
#1569
THE EFFECTS OF P’, P’-DDE ON
REPRODUCTIVE SUCCESS OF THE
FATHEAD MINNOW (PIMEPHALES
PROMELAS). E. J. Ray1 and D. S. Barber2. 1School
of Natural Resources and Environment, University
of Florida, Gainesville, FL and 2Center for
Environmental and Human Toxicology, University of
#1570
INHIBITION OF GERMINAL VESICLE
BREAKDOWN IN XENOPUS OOCYTES IN
VITRO BY POLYBROMINATED DIPHENYL
ETHERS. D. J. Fort1, R. L. Rogers1, G. D.
Anderson1, P. D. Guiney2 and J. A. Weeks2. 1Fort
Environmental Laboratories, Stillwater, OK and 2SC
Johnson & Son, Racine, WI.
#1571
ENDOCRINE DISRUPTION BY ATRAZINE
AND OTHER ENVIRONMENTAL
CONTAMINANTS ON NATIVE NEW JERSEY
FROGS. M. Gutierrez1, T. Ledoux2, K. R. Cooper1
and M. G. Robson3. 1Joint Graduate Program in
Toxicology, Rutgers University, Piscataway, NJ,
2
Division of Science, Research and Technology, New
Jersey Department of Environmental Protection,
Trenton, NJ and 3School of Public Health, UMDNJ
- Robert Wood Johnson Medical School, Piscataway,
NJ.
#1572
TIME AND DOSE-DEPENDENT THYROID
HORMONE RELEASE FROM XENOPUS
THYROID GLAND CULTURES IN RESPONSE
TO THYROID STIMULATING HORMONE
AND INHIBITION BY METHIMAZOLE. M.
W. Hornung1, S. J. Degitz1, K. R. Thoemke2, J. J.
Korte1, L. M. Korte3, M. E. Bugge3 and J. E. Tietge1.
1
NHEERL, MED., U.S. EPA, Duluth, MN, 2National
Research Council, Duluth, MN and 3Student
Services Contractor, U.S. EPA, Duluth, MN.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: ECOTOXICOLOGY
Chairperson(s): Louis Trombetta, St. Johns University, Jamaica, NY.
#1563
#1564
#1565
MUMMICHOG CDNA ARRAYS AS A
TOOL FOR MONITORING CHROMIUM
REMEDIATION AT AN ESTUARINE
SUPERFUND SITE. J. A. Roling1, P. B. Key2, J.
Gardea-Torresdey3, L. J. Bain1 and W. S. Baldwin1.
1
Biological Sciences, University of Texas-El Paso, El
Paso, TX, 2Center for Coastal Environmental Health,
NOAA, Charleston, SC and 3Chemistry, University
of Texas-El Paso, El Paso, TX.
DAPHNIA MAGNA ECOTOXICOGENOMICS
REVEALS UNIQUE EXPRESSION PROFILES
FOR METALS AND ORDNANCE RELATED
CHEMICALS. H. C. Poynton1, J. R. Varshavsky1,
A. Kennedy2, X. Guan2, J. Steevens3, B. Chang1, S.
Chan1, P. S. Holman1, A. V. Loguinov1, D. Bauer4,
J. K. Colbourne4, E. J. Perkins3 and C. D. Vulpe1.
1
Nutri. Sciences. and Toxicology, UC Berkeley,
Berkeley, CA, 2Analytical Services Inc., Vicksburg,
MS, 3Environmental Laboratory, Engineer
Research and Development Center, U.S. Army
Corps of Engineers, Vicksburg, MS and 4Center for
Genomics and Bioinformatics, Indiana University,
Bloomington, IN.
WEDNESDAY
QUANTITATIVE RT-PCR ASSAYS FOR
FATHEAD MINNOW STAR AND CYP11A AND
EFFECTS OF KETOCONAZOLE ON THEIR
EXPRESSION IN VIVO. D. L. Villeneuve1, E. F.
Orlando2, K. J. Greene1, L. S. Blake1, K. M. Jensen1,
M. D. Kahl1, E. A. Makynen1, E. J. Durhan1, A. L.
Linnum1, A. L. Miracle3 and G. T. Ankley1. 1U.S.
EPA Mid-Continent Ecology Division, Duluth,
MN, 2HBOI, Florida Atlantic University, Ft. Pierce,
FL and 3Pacific Northwest National Laboratory,
Richland, WA. Sponsor: J. Mata.
186
45th Annual
Meeting & ToxExpo
#1573
THE PITUITARY RESPONSE TO CHEMICAL
THYROID AXIS DISRUPTION IN X. LAEVIS.
K. R. Thoemke1, J. J. Korte2, M. W. Hornung2, M. E.
Bugge3, L. M. Korte3, G. W. Holcombe2, J. E. Tietge2
and S. J. Degitz2. 1National Research Council,
Duluth, MN, 2NHEERL, MED., U.S. EPA, Duluth,
MN and 3Student Services Contractor, U.S. EPA,
Duluth, MN.
#1574
EFFECTS OF P, P’-DDE ON BONE TISSUE
IN ADULT MALE COMMON FROGS. P. Lind1,
R. Lundberg1, M. Ronn2, C. Hernhag2, A. Leiva
Presa3, B. M. Jenssen3 and J. Orberg2. 1Division of
Biochemical Toxicology, Institute of Environmental
Medicine, Karolinska Institutet, Stockholm, Sweden,
2
Department of Environmental Toxicology, Uppsala
University, Uppsala, Sweden and 3Department of
Biology, Norwegian University of Science and
Technology, Trondheim, Norway.
#1575
DO EDCS EFFECT BONE TISSUE IN GREAT
LAKES HERRING GULLS? R. Lundberg1, G.
A. Fox2 and M. P. Lind1. 1Division of Biochemical
Toxicology, Institute of Environmental Medicine,
Karolinska Institutet, Stockholm, Sweden and
2
National Wildlife Research Centre, Canadian
Wildlife Service, Ottawa, ON, Canada.
#1576
COMPARATIVE EFFECTS OF CARBOFURAN
AND DIAZINON ON TIME OF FLIGHT IN
PIGEONS (COLUMBA LIvia): POTENTIAL
FOR AGROCHEMICAL EFFECTS ON
MIGRATION. J. M. Brasel and C. A. Pritsos.
Nutrition, University of Nevada, Reno, NV.
#1577
TOXIN BINDING ABILITY OF SOILS
CONSUMED BY PARROTS IN THE PERUviaN
AMAZON. J. F. Taylor1, D. Brightsmith2, H.
Huebner1 and T. Phillips1. 1Veterinary Integrative
Biosciences, Texas A&M, College Station, TX and
2
Biology, Duke University, Durham, NC.
#1578
TOXICOPATHOLOGICAL ANALYSIS OF
THE IMPACT OF SODIUM ARSENATE
(NA2HASO4. 7H2O) ON SKIN OF THE
CATFISH CLARIAS BATRACHUS (LINN). A.
K. Singh, I. Chatterjee and T. K. Banerjee. Zoology,
Banaras Hindu University, Varanasi, Uttar Pradesh,
India.
#1579
TRIBUTYLTIN INDUCED NEUROTOXICITY
FOLLOWING CHRONIC EXPOSURE IN THE
STINGRAY UROLOPHUS JAMAICENSIS
(YELLOW STINGRAY). J. Dwivedi1 and L.
D. Trombetta2, 1. 1Biological Sciences, St. John’s
University, New York and 2Pharmaceutical Sciences,
St. John’s University, Jamaica, NY.
#1580
SUBCHRONIC TOXIC EFFECTS AND
ACCUMULATION OF HEXAHYDRO-1, 3,
5-TRINITRO-1, 3, 5-TRIAZINE (RDX) IN
ZEBRAFISH (DANIO RERIO). S. mukhi1 and
R. Patino2. 1Environmental Toxicology, Texas Tech
University, Lubbock, TX and 2US Geological Survey
Texas Cooperative Fish & Wildlife Research Unit,
Texas Tech University, Lubbock, TX.
187
#1581
EVALUATION OF BROMINATED FLAME
RETARDANTS IN RELATIONSHIP TO
BOTTLENOSE DOLPHIN IMMUNITY. J.
Stuckey1, T. Romano2, 6, C. Rice3, 6, J. EuDaly6, G.
Mitchum5, G. Bossart4, 6, P. Fair5, 6 and M. PedenAdams6, 2. 1College of Charleston, Charleston, SC,
2
Mystic Aquarium, Mystic, CT, 3Clemson University,
Clemson, SC, 4Harbor Branch Oceanographic
Institute, Ft. Pierce, FL, 5NOS/NOAA, Charleston,
SC and 6MUSC, Charleston, SC.
#1582
VALIDATION OF AN EUKARYOTIC
GENOTOXICITY SCREENING ASSAY FOR
ENVIRONMENTAL MONITORING. A. Knight1,
P. Cahill1 and R. Walmsley2. 1Gentronix Ltd.,
Manchester, United Kingdom and 2Faculty of Life
Sciences, University of Manchester, Manchester,
United Kingdom. Sponsor: S. Dean.
#1583
INVESTIGATING ENANTIOMERSPECIFIC EFFECTS OF THE CHIRAL
PHARMACEUTICAL POLLUTANTS
PROPRANOLOL (β-BLOCKER),
FLUOXETINE (SSRI), AND IBUPROFEN
(ANALGESIC) TO MODEL AQUATIC
ORGANISMS. J. K. Stanley1, A. J. Ramirez2, M.
Mottaleb2, C. K. Chambliss2 and B. W. Brooks3.
1
Biology, Baylor University, Waco, TX, 2Chemistry
and Biochemistry, Baylor University, Waco, TX and
3
Environmental Studies, Baylor University, Waco,
TX.
#1584
RAPID ENVIRONMENTAL IMPACT
SCREENING OF REACTIVE NANO-IRON
PARTICLES (RNIP) USING DAPHNIA AND
FATHEAD MINNOWS. E. Oberdorster1, P. Larkin2
and D. Rejeski3. 1Biology, Southern Methodist
University, Dallas, TX, 2EcoArray, Inc., Alachua,
FL and 3Woodrow Wilson Center for International
Scholars, Washington, DC.
#1585
USING BLOOD PLASMA AS A
NONDESTRUCTIVE MEANS FOR
MONITORING PERSISTENT ORGANIC
POLLUTANTS IN WHITE STURGEON
FROM THE COLUMBIA RIVER BASIN. D.
Gundersen1, J. Schleier1, E. Bredeweg1, M. Webb2,
E. Foster3 and B. Cady4. 1Environmental Science
Program, Pacific University, Forest Grove, OR,
2
US Fish and Wildlife Service, Bozeman, MT,
3
Department of Environmental Quality, Portland, OR
and 4Washington Department of Fish and Wildlife,
Vancouver, WA.
#1586
MOVEMENT OF MERCURY FROM
CONTAMINATED SOIL INTO AN AQUATIC
FOOD CHAIN. A. C. Nichols, D. A. Steffy and C.
R. Kohute. Physical and Earth Sciences, Jacksonville
State University, Jacksonville, AL.
#1587
TRIVOREX: SAFETY AND EFFICACY OF
A NEUTRALIZER AND ABSORBENT FOR
CHEMICAL SPREADING AND TREATMENT
OF CHEMICAL WASTES. F. Burgher1, C.
Godard1, H. Coudouel1, A. H. Hall2 and L. Mathieu1.
1
Scientific researches, Prevor Laboratory, Paris,
France and 2Toxicology, TCMTS, Elk Mountain,
WY.
WEDNESDAY
45th Annual
Meeting & ToxExpo
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
#1595
APPLICATION OF HISTOLOGICAL
EVALUATION TO ENHANCE THE BOVINE
CORNEAL OPACITY AND PERMEABILITY
(BCOP) ASSAY. J. W. Harbell, G. Mun and R.
D. Curren. Institute for In Vitro Sciences, Inc.,
Gaithersburg, MD.
#1596
A NEW IN VITRO TECHNIQUE TO COMPARE
THE TOXICITIES OF SURFACTANTS IN
ISOLATED RABBIT AND HUMAN CORNEAS.
G. Holley1, D. Ghate1, D. Bagley2, M. Blazka2 and H.
F. Edelhauser1. 1Ophthalmology, Emory University
Eye Center, ATlanta, GA and 2Research and
Development, Colgate- Palmolive Co., Piscataway,
NJ.
#1597
EVALUATING THE PRECISION,
SENSITIVITY AND CORRELATION OF THE
HEN’S EGG TEST – CHORIOALLANTONIC
MEMBRANE METHOD (HET-CAM) FOR
THE ASSESSMENT OF EYE IRRITATION
POTENTIAL OF FORMULATED PERSONAL
RINSE-OFF PRODUCTS. X. Yan1, C. Piterski1 and
S. Nitka2. 1Playtex Products, Inc., Allendale, NJ and
2
Consumer Product Testing Co., Fairfield, NJ.
#1598
EVALUATION OF THE OCULAR IRRITATION
POTENCY OF SHAMPOOS USING THE SLUG
MUCOSAL IRRITATION TEST. E. Adriaens1,
B. De Wever2 and J. Remon1. 1Lab. Pharmaceutical
Technology, Ghent University, Gent, Belgium
and 2De Wever Consulting bvba, Oud-Turnhout,
Belgium.
#1599
FRAGRANCE IMPACT ON MARKETED AIR
FRESHENER PRODUCTS BY BCOP ASSAY
AND HISTOLOGY. K. Cater1, C. Reyes2 and J.
Harbell2. 1The Dial Corporation, Scottsdale, AZ and
2
IIVS, Gaithersburg, MD.
#1600
DETECTION OF EYE IRRITATION
POTENTIAL OF HAIR DYES WITH A
RECONSTITUTED HUMAN CORNEAL
EPITHELIUM MODEL. C. Faller1, M. Bracher1,
P. Aeby1, J. Rolle1 and C. Goebel2. 1Toxicology,
Cosmital SA (WELLA AG), Marly, Switzerland and
2
Product Safety, WELLA AG, Darmstadt, Germany.
Sponsor: F. Gerberick.
#1601
A HUMAN CORNEAL EPITHELIAL
CULTURE MODEL FOR EVALUATION
OF OCULAR IRRITATION. L. Amenuvor, P.
Zeigler, S. A. Hauber, K. N. Roberts and M. J.
Powers. Cambrex Bio Science Walkersville, Inc.,
Walkersville, MD.
POSTER SESSION: ALTERNATIVE MODELS FOR ASSESSMENT
OF OCULAR AND DERMAL TOXICITY
Chairperson(s): R. J. Babu, Auburn University, Auburn, AL and John
Harbell, Institute for In Vitro Sciences, Inc., Gaithersburg, MD.
#1588
IN VITRO MODELS TO PREDICT THE IN
VIVO METABOLISM OF AROMATIC AMINES
IN THE SKIN. C. Goebel2, H. J. Beck1 and H.
Scheffler2. 1TOXICOLOGY, Cosmital SA, Marly,
Switzerland and 2product safety, Toxicology,
Darmstadt, Germany. Sponsor: F. Gerberick.
#1589
REGISTRATION OF CHEMICALS IN
EUROPE: IN VITRO DERMAL PENETRATION
STUDIES. A. B. McEwen, A. Strong and K.
Dummer. BioDynamics Research Limited, Rushden,
United Kingdom. Sponsor: R. Harling.
#1590
DEVELOPMENT OF A METABOLISMBASED PEPTIDE REACTIVITY ASSAY FOR
SCREENING THE SKIN SENSITIZATION
POTENTIAL OF PROHAPTENS. J. D. Vassallo1,
F. G. Gerberick1, P. Riley1, M. Quijano1, R. L.
Dobson1 and J. Lepoittevin2. 1Central Product Safety,
Procter & Gamble, Cincinnati, OH and 2Laboratorie
de Dermatochimie, Universite Louis Pasteur,
Strasbourg, France.
#1591
#1592
EVALUATION OF EPIDERM AS A MODEL
TO STUDY IRRITATION AFTER EXPOSURE
TO VARIOUS ALIPHATIC HYDROCARBONS
FOUND IN JET FUELS. M. Singh1, R. Babu2,
A. Chatterjee1, S. Fulzele1, M. Klausner3 and J.
Kubilus3. 1Auburn University, Auburn, AL, 2College
of Pharmacy, Florida A&M University, Tallahassee,
FL and 3MatTek Corporation, Ashland, MA.
INTEGRATION OF THE 3R’S IN CHEMICAL
TOXICITY TESTING. L. Waterson, S. Wilkins,
P. Rees and M. Wing. Huntingdon Life Sciences,
Cambridgeshire, United Kingdom. Sponsor: E.
Moore.
WEDNESDAY
#1593
DEVELOPMENT OF AN IMPROVED
EPIOCULAR TEST PROTOCOL FOR
SCREENING OF SEVERE OCULAR
IRRITANTS. G. R. Jackson, P. Hayden, J. Kubilus,
Y. Kaluzhny and M. Klausner. R & D, MatTek
Corporation, Ashland, MA.
#1594
EYE IRRITANCY TESTING OF HOUSEHOLD
CLEANING PRODUCTS IN THE IN VITRO
ISOLATED CHICKEN EYE (ICE) ASSAY. K.
Schutte1 and M. K. Prinsen2. 1Product Safety &
Regulatory Affairs, Procter & Gamble Eurocor,
Strombeek-Bever, Belgium and 2Toxicology &
Applied Pharmacology, TNO Quality of Life, Zeist,
Netherlands.
188
45th Annual
Meeting & ToxExpo
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
#1609
A TWO-TIER APPROACH FOR EVALUATING
THE RELEVANCE OF MULTIROUTE
EXPOSURES IN ESTABLISHING DRINKING
WATER GOALS FOR VOLATILE ORGANIC
CHEMICALS. R. Carrier2 and K. Krishnan1.
1
SEST, University of Montréal, Montréal, QC,
Canada and 2Water Quality and Health Bureau,
Health Canada, Ottawa, ON, Canada.
#1610
PROBABILISTIC MODEL FOR MICROBIAL
RISK ASSESSMENT IN RECREATIONAL
WATERS. J. K. Tolson1, 2, C. P. Villaroman2, E.
M. Tufariello1, S. R. Custance2, R. Lanyon3, T.
C. Granato3, J. Zmuta3 and C. J. Petropoulou2.
1
GeoSyntec Consultants, Tampa, FL, 2GeoSyntec
Consultants, Baton Rouge, LA and 3Metropolitan
Water Reclamation District of Greater Chicago,
Chicago, IL.
#1611
RISK OF CRYPTOSPORIDIUM INFECTION
AMONG BALTIMORE URBAN ANGLERS.
J. D. Roberts1, 2, E. K. Silbergeld2 and T. Graczyk3.
1
ChemRisk, Inc., San Francisco, CA, 2Department
of Environmental Health Sciences, Johns Hopkins
University, Bloomberg School of Public Health,
Baltimore, MD and 3Department of Molecular
Microbiology and Immunology, Johns Hopkins
University, Bloomberg School of Public Health,
Baltimore, MD.
#1612
ASSESSMENT OF LA SEWAGE SPILLS ON
SANTA MONICA BAY BEACHES. S. Hong1, D.
Proctor1 and B. Finley2. 1Exponent, Irvine, CA and
2
ChemRisk, SanFrancisco, CA.
#1613
HEALTH RISK ASSESSMENT OF
CHLOROBENZENEDIAMINE IN DRINKING
WATER. V. S. Bhat, G. L. Ball, C. J. McLellan and
C. D. Gillilland. NSF International, Ann Arbor, MI.
Sponsor: M. Dourson.
#1614
MEASUREMENT OF BLOOD IGE
IN INDIVIDUALS EXPOSED TO
FORMALDEHYDE. K. OHMICHI1, M.
Komiyama1, 2, 3, Y. Matsuno1, 2, 3, Y. Sawabe4,
H. Miyaso1, E. Todaka1, 2, 3, H. Fukata1, 2, M.
Ohmichi5, T. Kadota1, 2, F. Nomura4 and C. Mori1,
2, 3 1
. Department of Bioenvironmental Medicine,
Chiba, Japan, 2Center of Environmental Health
Science for Future Generations (NPO), Chiba,
Japan, 3Center for Environment, Health and
Field Sciences, Chiba University, Kasiwa, Japan,
4
Department of Molecular Diagnosis, Graduate
School of Medicine, Chiba University, Chiba, Japan
and 5Chiba City Social Welfare Administrative
Office, Chiba, Japan.
#1615
NON-CYTOTOXIC CELL PROLIFERATION
AS A SUBCOMPONENT OF THE MODE OF
ACTION FOR FORMALDEHYDE-INDUCED
CARCINOGENESIS. C. Thompson1 and R. C.
Grafstrom2. 1ORD/NCEA-W, U.S. EPA, Washington,
DC and 2Institute of Environmental Medicine,
Karolinska Institutet, Stockholm, Sweden. Sponsor:
S. Barone.
POSTER SESSION: RISK ASSESSMENT I
Chairperson(s): George Alexeeff, CAL EPA, Oakland, CA and David
Mattie, AFRL, Wright Patterson Air Force Base, OH.
#1602
RISK ASSESSMENT FOR PCBs IN DRINKING
WATER. J. Avalos1, R. A. Howd2 and R. Brodberg1.
1
OEHHA, Cal/EPA, Sacramento, CA and 2OEHHA,
Cal/EPA, Oakland, CA.
#1603
PREDICTION OF THE HEALTH EFFECTS
OF POLYCHLORINATED BIPHENYLS
(PCBs) AND THEIR METABOLITES USING
QUANTITATIVE STRUCTURE TOXICITY
RELATIONSHIP (QSTR). P. Ruiz, O. Faroon, H.
Hansen and M. Mumtaz. CDC/ATSDR, Atlanta, GA.
#1604
DEVELOPMENTAL EFFECTS ASSOCIATED
WITH ENVIRONMENTAL PCB EXPOSURE:
A REANALYSIS THROUGH EXPOSURE
STANDARDIZATION AND SYSTEMATIC
APPLICATION OF CAUSALITY CRITERIA.
N. El Majidi1, M. Bouchard2, 1, N. Gosselin1,
D. Schoen3 and G. Carrier1, 2. 1Occupational &
Environmental Health, Universite de Montréal,
Montréal, QC, Canada, 2Institut national de sante
publique du Quebec, Montréal, QC, Canada and
3
Health Canada, Longueuil, QC, Canada.
#1605
PCB CONGENER-SPECIFIC RISK
ASSESSMENT. J. Yang and A. G. Salmon.
OEHHA, Cal/EPA, Oakland, CA.
#1606
DERIVATION OF A DRINKING WATER
ACTION LEVEL FOR TRIETHYL
PHOSPHATE. C. J. Inhof1, M. H. Whittaker1,
A. Gebhart2 and F. Hammer2. 1ToxServices,
Washington, DC and 2Underwriters Laboratories,
Inc., Northbrook, IL.
#1607
CLASS-BASED DRINKING WATER ACTION
LEVEL FOR ISOBORNYL ACRYLATE
ISOMERS. M. H. Whittaker1, A. Gebhart2 and F.
Hammer2. 1ToxServices, Washington, D.C., DC and
2
Underwriters Laboratories, Northbrook, IL.
#1608
DEVELOPMENT OF A HUMAN
HEALTH-BASED DRINKING WATER
MAXIMUM CONTAMINANT LEVEL FOR
PERCHLORATE. G. B. Post1 and P. Cohn2.
1
Science, Research, and Technology, New Jersey
Department of Environmental Protection, Trenton,
NJ and 2Environmental Health Service, NJ
Department of Health and Senior Services, Trenton,
NJ.
189
WEDNESDAY
45th Annual
Meeting & ToxExpo
#1616
#1617
#1618
#1619
#1620
#1621
TIME AND DOSE-DEPENDENT FACTORS
IN GENETIC SUSCEPTIBILITY TO
ACETAMINOPHEN HEPATOTOXICITY. A.
Hege1, 2, P. Ross2, L. Balletta3, B. Bradford2, G.
Boorman4, R. Tennant4, 1, M. Bogue5, K. Paigen5,
D. Threadgill3, 1 and I. Rusyn2, 1. 1Curriculum in
Toxicology, UNC-Chapel Hill, Chapel Hill, NC,
2
Environmental Sciences and Engineering, UNCChapel Hill, Chapel Hill, NC, 3Department of
Genetics, UNC-Chapel Hill, Chapel Hill, NC,
4
NIEHS, Research Triangle Park, NC and 5The
Jackson Laboratory, Bar Harbor, ME.
DRUG TOXICITY SIGNATURES FOR
ACETAMINOPHEN USING THE
PHARMGENIX PANEL OF RATS. S. H. Nye1, D.
Evans1, J. Baye1, H. Vernon1, M. Hessner2, X. Wang2,
R. J. Roman2, 1 and H. J. Jacob2, 1. 1PhysioGenix, Inc.,
Milwaukee, WI and 2Medical College of Wisconsin,
Milwaukee, WI. Sponsor: Y. Dragan.
EVALUATION OF THE DRUG INTERACTION
BETWEEN DESIPRAMINE ADMINISTERED
ORALLY AND MORPHINE ADMINISTERED
SUBCUTANEOUSLY: EFFECTS ON
ANTINOCICEPTIVE RESPONSE AND
LETHALITY IN RATS. E. Zahalka and H. Seung.
Gene Logic, Inc., Gaithersburg, MD.
EVALUATION OF THE DRAG INTERACTION
BETWEEN DESIPRAMINE ADMINISTERED
ORALLY AND COCAINE ADMINISTERED
INTRAPERITONEALLY: EFFECTS ON
LETHALITY IN RATS. H. Seung and E. Zahalka.
Gene Logic, Inc., Gaithersburg, MD.
TOXICOGENOMICS APPROACHES TO
DRUG-INDUCED PHOSPHOLIPIDOSIS:
ESTABLISHMENT OF IN VITRO SCREENING
SYSTEM AND IDENTIFICATION OF
CANDIDATE BLOOD BIOMARKERS. H.
Sawada, K. Taniguchi, I. Mori, T. Iwachido, Y.
Nakashita and K. Takami. Pharmaceutical Research
Division, Takeda Pharmaceutical Company Limited,
Osaka, Japan.
RISK ASSESSMENT OF HUMAN
MYELOTOXICITY BY ANTICANCER
DRUGS: A PREDICTIVE MODEL USING
FIVE CAMPTOTHECIN DERIVATIVES AND
THE IN VITRO COLONY FORMING UNIT
GRANULOCYTE/MACROPHAGE (CFU-GM)
ASSAY. N. Masubuchi1, R. D. May2, R. Atsumi1,
O. Okazaki1 and K. Sudo1. 1Daiichi Pharmaceutical
Co., Ltd., Tokyo, Japan and 2Southern Research
Institute, Birmingham, AL.
WEDNESDAY
#1622
SUBCHRONIC ORAL TOXICITY OF RDX IN
FISCHER 344 RATS. G. leach. Toxicty Evaluation
program, U.S. Army Center for Health Promotion
and Preventive Medicine, Aberdeen Proving Ground,
MD.
#1623
NORDIC EXPERT GROUP: EVALUATION OF
HEALTH RISKS OF AMMONIA. G. Johanson1,
2
, A. Alexandrie2, J. Jarnberg2 and J. Liesivuori3.
1
Karolinska Institute, Stockholm, Sweden, 2National
Institute for Working Life, Stockholm, Sweden and
3
University of Kuopio, Kuopio, Finland.
190
#1624
ACUTE EXPOSURE GUIDELINE LEVELS
(AEGLS) FOR TETRANITROMETHANE
(TNM). S. Milanez1 and K. Blackman2. 1Oak
Ridge National Laboratory, Oak Ridge, TN and
2
Department of Homeland Security, FEMA,
Washington, DC.
#1625
RISK ASSESSMENT: AMMONIUM
BIFLUORIDE IN INDUSTRIAL CLEANING
APPLICATIONS. D. A. Daggett1, J. B. Leikin2, B.
D. Bradshaw1, A. M. Carrao1, F. A. Heitfeld1, K. E.
Long1, S. Ren1 and J. D. Hamilton1. 1Global Product
Safety, JohnsonDiversey, Inc., Sturtevant, WI and
2
Evanston Northwestern Healthcare - OMEGA,
Glenview, IL.
#1626
RISK ASSESSMENT OF VOLATILE
CONTAMINANT EMISSIONS FROM AIR
FRESHENERS. T. Petry1, A. Jespers2, F. J.
Joachim3, R. A. Mascarenhas4, A. R. Speed4 and
Universtiy of. Vedula3. 1The Weinberg Group LLC,
Brussels, Belgium, 2Sara Lee HBCR, The Hague,
Netherlands, 3S.C. Johnson, Racine, WI and 4Reckitt
Benckiser, Hull, United Kingdom.
#1627
EMPIRICAL EVALUATION OF SUFFICIENT
SIMILARITY IN DOSE-RESPONSIVENESS
FOR MIXTURES OF MANY CHEMICALS.
L. G. Stork1, C. Gennings1, W. Carter, Jr.1, L.
Teuschler2 and E. Carney3. 1Biostatistics, Virginia
Commonwealth University, Richmond, VA, 2U.S.
EPA, Cincinnati, OH and 3The Dow Chemical
#1628
ASSESSMENT OF CHEMICAL MIXTURES
OF SIMILAR AND DISSIMILAR
MECHANISMS OF TOXICITY. M. Mumtaz, H.
Hansen, H. Hicks, P. Ruiz and C. De Rosa. CDC/
ATSDR, Atlanta, GA.
#1629
AN OVERVIEW OF CYANIDE TOXICITY.
J. B. Taylor1, N. Roney1, C. Harper1, M. Fransen2
and B. A. Fowler1. 1Agency for Toxic Substances
and Disease Registry, Atlanta, GA and 2Syracuse
Research Corp, Syracuse, NY.
#1630
A VALIDATION STUDY OF THE PKA-CLOGP
IN SILICO MODEL FOR PREDICTING
PHOSPHOLIPIDOSIS-INDUCING
POTENTIAL. D. Pelletier and N. Greene.
Molecular & Investigative Toxicology, Pfizer Global
Research & Development, Groton, CT.
#1631
STATISTICAL METHODS FOR HANDLING
CENSORED DIOXIN/FURAN CONGENER
DATA. C. J. Saranko1, J. K. Tolson2, 1, R. Budinsky3,
B. Landenberger3, S. M. Roberts4 and K. M. Portier4.
1
GeoSyntec Consultants, Tampa, FL, 2GeoSyntec
Consultants, Baton Rouge, LA, 3The Dow Chemical
Company, Midland, MI and 4University of Florida,
Gainesville, FL.
#1632
ORAL BIOACCESSIBILITY OF DIOXINS/
FURANS FROM INDUSTRIAL SOILS USING
A SIMULATED HUMAN G.I. TRACT. J.
Warmerdam, B. Finley and K. Fehling. ChemRisk,
San Francisco, CA.
45th Annual
Meeting & ToxExpo
#1633
THE ABSORPTION AND METABOLISM
OF INHALED BENZO(A)PYRENE IN THE
ISOLATED AND PERFUSED RAT LUNG
DOES NOT INCREASE LINEARLY WITH
INCREASING EXPOSURES. P. Ewing, A.
Ryrfeldt and P. Gerde. Environmental medicine,
Karolinska Institutet, Stockholm, Sweden.
#1634
EXPOSURE AND RISK ASSESSMENT FOR
PERFLUOROOCTANOATE (PFOA) IN
APPAREL AND CARPETING. T. Roth1, W.
Knaup2, C. Ho3, R. Jung1 and H. Panke4. 1CPS
Toxicology, Clariant GmbH, Sulzbach a.T.,
Germany, 2R&D Fluorotelomers, Clariant GmbH,
Burgkirchen, Germany, 3Corporation Analysis
Laboratory, Clariant Corporation, Charlotte, NC and
4
TLP, Claraint GmbH, Frankfurt, Germany. Sponsor:
G. Kennedy.
AN EVALUATION OF THE MUTAGENIC
MODE OF ACTION FOR FOUR
ENVIRONMENTAL CARCINOGENS. N.
Keshava, G. M. Woodall, S. Rice, B. Sonawane
and I. Cote. Office of Research and Development,
Environmental Protection Agency, Washington, DC.
#1636
PUSHING THE ENVELOPE: PRELIMINARY
METHODOLOGY FOR INCIDENT-BASED
RISK ASSESSMENT FOR BIOTHREAT
AGENTS. T. Nichols1, I. Baumel1, C. SonichMullin1, T. Bill2, T. Negley2, S. Massulik2, M.
Odin2, P. McClure2, P. Coleman2, D. A. Gray2 and
P. McGinnis2. 1U.S. EPA, Cincinnati, OH and
2
Syracuse Research Corporation, Syracuse, NY.
#1637
QUICK REFERENCE LIST OF TOXINS AND
POTENTIAL CLINICAL MANIFESTATIONS.
M. J. Stratton1, 2. 1Moxie Jean Stratton, Touro
University College of Osteopathic Medicine, Napa,
CA and 2Undergraduate Degree in Liberal Arts ‘99,
Sarah Lawrence College, Bronxville, NY.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: CARCINOGENESIS—MODULATION
Chairperson(s): Samuel Cohen, University of Nebraska Medical Center,
Omaha, NE and Robert Schiestl, University of California Los Angeles, Los
Angeles, CA.
#1638
ESTABLISHING “SAFE DRUG CARRYOVER
LEVELS” (SDCLS) IN MEDICATED ANIMAL
FEEDS. E. R. Nestmann and B. S. Lynch. CANTOX
Health Sciences Intl., Mississauga, ON, Canada.
#1639
USE OF MULTI-CRITERIA DECISION
ANALYSIS TOOLS TO FACILITATE WEIGHTOF-EVIDENCE EVALUATION IN HUMAN
HEALTH RISK ASSESSMENT. I. Linkov1, K. F.
Satterstrom1, L. Green1, G. Kiker2 and T. Bridges3.
1
Cambridge Environmental Inc., Cambridge,
MA, 2University of Florida, Gainesville, FL and
3
Engineer Research and Development Center, U.S.
Army Corps of Engineers, Vicksburg, MS.
#1640
USE OF BMC MODELING AND
CATEGORICAL REGRESSION TO
EVALUATE ACUTE SENSORY IRRITATION
FROM CHLOROPICRIN VAPOR. L. T. Haber, E.
Hack and M. L. Dourson. TERA, Cincinnati, OH.
SYSTEMS BIOLOGY MODELS FOR
INTEGRATION OF DIVERSE STUDIES OF
THE DEVELOPING NEOCORTEX AFTER
EXPOSURE TO LOW DOSE RADIATION
FROM EXTERNAL AND INTERNAL
SOURCES. W. C. Griffith, N. M. DeFrank, J.
M. Gohlke, E. J. Gribble and E. M. Faustman.
191
#1642
CHEMOPREVENTION OF EARLY STAGE
PROSTATE CARCINOGENESIS BY GAMMATOCOPHEROL IN PROBASIN/SV40 T
ANTIGEN TRANSGENIC RATS. K. takeshita1,
S. Takahashi1, S. Azman1, S. Sugiura1, M. Tang1, K.
Abe2 and T. Shirai1. 1Experimental Pathology and
Tumor Biology, Nagoya City University Graduate
School of Medical Sciences, Nagoya, Japan and
2
Eisai Co., Ltd., Tokyo, Japan.
#1643
ANTIOXIDANT N-ACETYL CYSTEINE
PREVENTS LYMPHOMA IN ATM DEFICIENT
MICE. R. H. Schiestl and R. Reliene. UCLA, Los
Angeles, CA.
#1644
EFFECT OF CELECOXIB ON
CYTOCHROME P450 EXPRESSION IN A RAT
HEPATOCARCINOGENESIS MODEL. M. E.
Salcido-Neyoy1, A. Sierra-Santoyo2, L. MarquezRosado1 and S. Villa-Trevino1. 1Cell Biology
Department, CINVESTAV-IPN, Mexico City, D.F.,
Mexico and 2Toxicology Section, CINVESTAV-IPN,
Mexico City, D.F., Mexico.
#1645
DEVELOPMENT OF NOVEL NITRATES FOR
COLON CANCER CHEMOPREVENTION.
G. K. Hagos1, V. Toader1, Q. Li1, D. D. Lantvit1,
S. Swanson1, R. E. Carroll2 and G. R. Thatcher1.
1
Medicinal chemistry and Pharmacognosy,
University of Illinois, chicago, IL and 2Chicago
Veterans Administration Medical center, chicago, IL.
#1646
ALTERATIONS IN POLYCYCLIC AROMATIC
HYDROCARBON INDUCED PHASE I AND II
ENZYME ACTIVITIES IN FEMALE MICE:
ROLE OF CHEMOPREVENTIVE AGENTS. S.
R. Kondraganti, L. Wang, W. Jiang, K. Muthiah and
B. Moorthy. Pediatrics, Baylor College of Medicine,
Houston, TX.
WEDNESDAY
#1635
#1641
45th Annual
Meeting & ToxExpo
#1647
USE OF GENE EXPRESSION PROFILING
TO STUDY MECHANISM OF SELENIUM
CHEMOPREVENTION OF RAT MAMMARY
CARCINOGENESIS. X. Zhang1, 2, K. Serikawa3,
R. Bumbgarner3 and H. Zarbl1, 2. 1Human Biology,
Fred Hutchinson Cancer Research Center, Seattle,
WA, 2Environmental and Occupational Health
Sciences, University of Washington, Seattle, WA and
3
Microbiology, University of Washington, Seattle,
WA.
#1648
ORAL CANCER CHEMOPREVENTION BY
BLACK RASPBERRIES. C. M. Weghorst, B. C.
Casto, C. L. Sardo, G. D. Stoner, E. Pearson and T.
J. Knobloch. The Ohio State University, Columbus,
OH.
#1649
PREVENTION OF IN VIVO AFLATOXIN B1INDUCED 8-HYDROXYDEOXYGUANOSINE
FORMATION IN MOUSE LUNG CELLS BY
PRE-TREATMENT WITH POLYETHYLENE
GLYCOL-CONJUGATED CATALASE. K.
A. Guindon, L. L. Bedard and T. E. Massey.
Pharmacology and Toxicology, Queen’s University,
#1650
#1651
#1652
#1653
EFFECTS OF ACUTE EXPOSURE
OF SELENAZOLIDINE PRODRUGS
OF L-SELENOCYSTEINE ON
CHEMOPREVENTIVE ENZYMES IN MICE
AND HEPA1C1C7 CELLS. W. M. El Sayed1, T.
Aboul Fadl1, J. G. Lamb1, J. C. Roberts2 and M. R.
Franklin1. 1University of Utah, Salt Lake City, UT
and 2University of Wisconsin, Madison, WI.
REDUCTION IN BASAL ARYL
HYDROCARBON RECEPTOR EXPRESSION
AND CYTOCHROME P450-1A1 INDUCTION
BY SOY CONSUMPTION. R. Singhal1, M.
Fergusson3, M. J. Ronis1, 3 and T. M. Badger2, 3.
1
Pharmacology/ Toxicology, University of Arkansas
for Medical Sciences, Little Rock, AR, 2Physiol/
Biophys, University of Arkansas for Medical
Sciences, Little Rock, AR and 3Arkansas Children’s
Nutrition Center, Little Rock, AR.
LONG-TERM TREATMENT WITH
BROMOCRIPTINE INHIBITS RAT UTERINE
ADENOCARCINOMA DEVELOPMENT. M.
Yoshida1, G. Watanabe2, T. Tanimoto1, K. Taya2 and
A. Maekawa1. 1Pathology, Sasaki Institute, Tokyo,
Japan and 2Veterinary Physiology, Tokyo University
of Agriculture and Technology, Tokyo, Japan.
Sponsor: C. Tohyama.
#1654
THE INDUCTION OF SUPEROXIDE
DISMUTASE AND INHIBITION OF
DIETHYLSTILBESTEROL INDUCED DNA
STRAND BREAKS BY DIALLY SULFIDE IN
MCF10A CELLS. M. L. McCaskill, C. Wilson, A.
Aboyade-Cole, L. Russel, A. Tucker and R. Thomas.
Florida A&M University, Tallahassee, FL.
#1655
EFFECT OF TRANSPLACENTAL AND
POSTNATAL EXPOSURE OF ZIDOVUDINE
(AZT) AND LAMIVUDINE (3TC) ON
MITOCHONDRIAL GENE EXPRESSION IN
C3B6F1trp53(+/-) TRANSGENIC MICE. F. W.
Lee1, S. M. Lewis1, L. H. Williams1, J. K. Dunnick2,
W. T. Allaben1 and J. E. Leakey1. 1Scientific
Coordination, NCTR, Jefferson, AR and 2NTP,
NIEHS, Reseach Triangle Park, NC.
#1656
ULTRAVIOLET RADIATION-INDUCED NONMELANOMA SKIN CANCER IN THE SKH:
HR HAIRLESS MOUSE: AUGMENTATION
OF TUMOR MULTIPLICITY BY
CHLOROPHYLLIN AND PROTECTION BY
INDOLE-3-CARBINOL. R. Cope1, 2, B. Stang1, C.
Loehr1 and N. Kerkvliet2. 1Veterinary Biosciences,
Oregon State University, Corvallis, OR and
2
Environmental and Molecular Toxicology, Oregon
State University, Corvallis, OR.
#1657
EFFECTS OF MELATONIN ON
DIMETHYLARSINIC ACID (DMA)-INDUCED
CYTOTOXICITY AND PROLIFERATION OF
THE BLADDER EPITHELIUM OF FEMALE
F344 RATS. T. Ohnishi, L. L. Arnold, M. Cano,
N. Clark and S. M. Cohen. University of Nebraska
Medical Center, Omaha, NE.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: DISEASE AND TOXICITY BIOMARKERS
Chairperson(s): Kyeonghee Lee, Battelle, Richland, WA and Peter Goering,
USFDA, Rockville, MD.
WEDNESDAY
CONSTITUTIVE AND ACTIVATIONINDUCIBLE CYCLOOXYGENASE-2
ACTIVITY PROMOTES SURVIVAL
OF PRIMARY HUMAN CHRONIC
LYMPHOCYTIC LEUKEMIA B CELLS. E. P.
Ryan1, S. H. Bernsetin2, N. Chiorazzi3, R. E. Felgar4
and R. P. Phipps1, 2, 4. 1Environmental Medicine,
University of Rochester, Rochester, NY, 2James P.
Wilmot Cancer Center, University of Rochester,
Rochester, NY, 3North Shore-LIJ Health System,
Institute for Medical Research, Manhasset, NY and
4
Pathology and Laboratory Medicine, University of
192
#1658
SYNTHESIS OF FATTY ACID ETHYL
ESTERS AS BIOLOGICAL MARKERS FOR
THE DIAGNOSIS OF FETAL ALCOHOL
SYNDROME. H. Kim1, 2, E. S. Roberts-Kirchhoff3,
1
, V. Hornik-Rosinski3, A. Ignagni1, E. E. Cole1,
K. Fleischmann1 and Y. Yuan1. 1Detroit R&D, Inc.,
Detroit, MI, 2Institute of Environmental Health
Sciences, Wayne State University, Detroit, MI
and 3Department of Chemistry and Biochemistry,
University of Detroit Mercy, Detroit, MI.
#1659
SEARCH FOR DISEASE BIOMARKERS IN
SERUM OF MICE WITH HEPATOCELLULAR
CARCINOMA. G. Gazzana and J. Borlak.
Fraunhofer Institut of Toxicology and Experimental
Medicine, Hannover, Germany.
45th Annual
Meeting & ToxExpo
#1660
DISCOVERY OF CYSTATIN C AS A
BIOMARKER OF CARDIAC CELL TYPE
SPECIFIC OXIDATIVE INJURY WITH
SHOTGUN PROTEOMICS. L. Xie, Y. Lin and Q.
Chen. University of Arizona, Tucson, AZ.
#1661
PULMONARY RESPONSES OF AKR/J MICE
EXPOSED TO CIGARETTE SMOKE AND/
OR LPS FOR 3-WEEK VIA NOSE-ONLY
INHALATION. K. M. Lee, R. A. Renne, S. J. Harbo,
J. C. Blessing, M. L. Clark, R. E. Johnson and K. M.
Gideon. Toxicology NW, Battelle, Richland, WA.
#1662
VALIDATION OF AN
ELECTROCHEMILUMINESCENCEBASED ASSAY FOR CARDIAC TROPONIN
T AND ITS KINETICS IN RAT SERUM
FOLLOWING EXPOSURE TO VARIOUS
CARDIOTOXICANTS. P. Nordone, R. Dunn, C.
Afshari and S. Thukral. Amgen, Thousand Oaks,
CA.
#1663
KIDNEY INJURY MOLECULE-1 (KIM-1) AS
AN EARLY BIOMARKER OF CADMIUM
(CD) NEPHROTOXICITY. W. C. Prozialeck1,
V. S. Vaidya2, A. Johnson2, J. Liu3, M. P. Waalkes3,
J. R. Edwards1, E. Diamantakos1, P. C. Lamar1, J.
Theusch4 and J. V. Bonventre2. 1Pharmacology,
Midwestern Universtiy of., Downers Grove, IL,
2
Brigham and Woman’s Hospital, Harvard Medical
School, MA, 3NCI, Research Triangle Park, NC and
4
Animal Resources, University of Chicago, Chicago,
IL.
EXAMINATION OF HFE C282Y/H63D
HETEROZYGOTES AS A POTENTIAL
HUMAN MODELING SYSTEM FOR LOW
LEVEL LIVER DAMAGE. N. H. Johnson, C.
Mauzy, D. Todd, J. Boyer, T. Minnick and S. Stevens.
Air Force Research Laboratory, Wright-Patterson
AFB OH, OH.
#1665
CYTOCHROME C: A NON-INVASIVE
BIOMARKER OF DRUG-INDUCED LIVER
TOXICITY. T. J. Miller, P. Espandiari, J. Zhang,
A. Knapton, J. L. Weaver, E. H. Herman and J. P.
Hanig. CDER, USFDA, Silver Spring, MD.
#1666
AGE- AND DOSE-RELATED SENSITIVITY IN
2-BUTOXYETHANOL F344 RAT MODEL OF
HEMOLYTIC ANEMIA AND DISSEMINATED
THROMBOSIS. Y. Ramot1, D. A. Lewis2, T. L.
Ortel2, M. Streicker3, G. Moser3, S. Elmore3, S.
Ward4, S. Peddada5 and A. Nyska4. 1Hadassah
Medical Center, Hebrew University, Jerusalem,
Israel, 2Division of Hematology, Duke University
Medical Center, Durham, NC, 3ILS, Research
Triangle Park, NC, 4Laboratory of Experimental
Pathology, NIEHS, Research Triangle Park, NC and
5
Biostatistics Branch, NIEHS, Research Triangle
Park, NC.
KIDNEY INJURY MOLECULE-1 (KIM-1)
EXPRESSION IN KIDNEY AND URINE
FOLLOWING ACUTE EXPOSURE TO
GENTAMICIN AND MERCURY. P. L. Goering1,
V. S. Vaidya3, R. P. Brown1, Z. Vakili1, B. A.
Rosenzweig2, A. M. Johnson3, K. L. Thompson2 and
J. V. Bonventre3. 1CDRH, USFDA, Silver Spring,
MD, 2CDER, USFDA, Silver Spring, MD and
3
Brigham and Women’s Hospital, Harvard Medical
School, Boston, MA.
#1668
BIO-FLUIDS, THE DYNAMIC RANGE OF
ABUNDANCES, AND THE APPROACH
TOWARDS TOXICITY BIOMARKERS BY
PROTEOMICS OF RAT URINARY PROTEINS.
M. S. Mondal1, I. Tcholakov1, P. Dinsmoor1, A.
Que2, M. Cabonce2, G. Stevens1 and S. Beushausen2.
1
Worldwide Safety Sciences, Pfizer, Inc., La Jolla,
CA and 2Worldwide Safety Sciences, Pfizer, Inc., St.
Louis, MO.
#1669
IDENTIFICATION OF EARLY BIOMARKERS
OF TUBULAR TOXICITY IN SPECIFIC
RENAL SEGMENTS AND IN URINE IN A RAT
MODEL OF NEPHROTOXICITY. A. Yang1, B.
Jessen1, C. Fuentealba2, O. Illanes2 and F. RamiroIbanez1. 1Pfizer Global Research & Development,
La Jolla Laboratories, San Diego, CA and 2Western
University of Health Sciences, Pomona, CA.
Sponsor: G. Stevens.
#1670
BIOMARKERS FOR DETECTING
MYOCARDIAL DAMAGE IN CYNOMOLGUS
MONKEY. K. Nakama, H. Minomo, H. Kadokura,
H. Uchino, Y. Torikai, K. Fukuzaki and R. Nagata.
Shin Nippon Biomedical Laboratries, Kagoshima,
Japan.
#1671
IS THERE A THRESHOLD LEVEL FOR
ALTERATIONS IN THYROID HORMONE
CONCENTRATIONS IN THE PRODUCTION
OF THYROID TUMORS IN F344/N RATS? G.
Travlos1, G. Pearse1, L. Betz3, M. Hooth2 and E.
Harvey3. 1Laboratory of Experimental Pathology,
NIEHS, Durham, NC, 2Toxicology Operations
Branch, NIEHS, Durham, NC and 3Constella Health
Sciences, Durham, NC. Sponsor: T. Brock.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: SAFETY ASSESSMENT—
PHARMACEUTICALS 2 (ONCOLOGY, ANTIINFLAMMATORY,
ANTIINFECTIVES, EXCIPIENTS, NATURAL PRODUCTS)
Chairperson(s): Virginia Pinney, Engineering Systems Inc., The
Woodlands, TX.
#1672
193
INFLUENCE OF EXPOSURE SCENARIOS ON
RESPONSE OF HUMAN GLIOMA CELLS TO
PACLITAXEL. J. M. Padowski1, E. M. Leslie2 and
G. M. Pollack2. 1Curriculum in Toxicology, UNC,
Chapel Hill, NC and 2Division of Pharmacotherapy,
UNC, Chapel Hill, NC. Sponsor: D. Holbrook.
WEDNESDAY
#1664
#1667
45th Annual
Meeting & ToxExpo
#1673
A UNIQUE LIPOSOMAL DOCETAXEL
FORMULATION (LE-DT) EXHIBITS
IMPROVED SAFETY, COMPARABLE
PHARMACOKINETICS AND THERAPEUTIC
EFFICACY TO TAXOTERE® S. Khan, A. Ahmad,
J. Anwer, P. Chen, C. Dudkowski, J. Ayoub, J.
Zang and I. Ahmad. Pharmacokinetics, Safety and
Efficacy, NeoPharm Inc., Waukegan, IL.
#1674
SUBCHRONIC TOXICITY EVALUATION OF
TAMOXIFEN + TARGRETIN IN FEMALE
RATS. T. L. Horn1, W. D. Johnson1, C. J. Detrisac2,
I. M. Kapetanovic3, J. A. Crowell3 and D. L.
McCormick1. 1IIT Research Institute, Chicago, IL,
2
Pathology Associates, Chicago, IL and 3National
Cancer Institute, Bethesda, MD.
#1675
#1676
#1677
THE TOXICITY ASSESSMENT OF TWO
ANTI-ANGIOGENIC SMALL MOLECULES
IN SPRAGUE-DAWLEY RATS AND BEAGLE
DOGS. M. D. Todd1, I. Hayward3, R. Willis1, C.
Zimmermann1, T. Polverino4, J. Engelhardt3, M.
Consenza1 and S. Wolford2. 1Toxicology, Amgen,
Inc., Thousand Oaks, CA, 2Covance Laboratories,
Inc., Madison, WI, 3Toxicologic Pathology, Amgen,
Inc., Thousand Oaks, CA and 4Cancer Biology,
Amgen, Inc., Thousand Oaks, CA.
DIFFERENTIAL HEPATIC EXPRESSION OF
GENES REGULATING DRUG AND LIPID
METABOLISM IN RATS EXPOSED TO
TARGRETIN. J. Naylor1, K. Torres1, T. L. Horn1, I.
M. Kapetanovic2, R. A. Lubet2, J. A. Crowell2 and D.
L. McCormick1. 1IIT Research Institute, Chicago, IL
and 2National Cancer Institute, Bethesda, MD.
THIRTEEN WEEK ORAL (GAVAGE)
TOXICITY STUDY OF L-SEMETHYLSELENOCYSTEINE (SEMC) IN
RATS. Y. Chen1, I. Kapetanovic2, J. Crowell2, C.
Ip3, R. Morrissey4 and A. Lyubimov1. 1Toxicology
Research Laboratory, University of Illinois
at Chicago, Chicago, IL, 2Division of Cancer
Prevention, National Cancer Institute, Bethesda,
MD, 3Roswell Park Cancer Institute, Buffalo, NY
and 4Pathology Associates Division, Charles River
Laboratories, Chicago, IL.
WEDNESDAY
#1678
RENAL TOXICITY AND
HYPERBILIRUBINEMIA OF A NOVEL
MATRIX METALLOPROTEINASE (MMP)
INHIBITOR IN CYNOMOLGUS MONKEYS.
K. Datta, R. Guzman, W. E. Maier, F. A. Grzemski
and D. G. Robertson. Worldwide Safety Sciences,
Pfizer Global R&D, Ann Arbor, MI.
#1679
PATTERNS OF LIVER-FUNCTION TEST
LEVELS DURING A LONG-TERM TRIAL
OF ACETAMINOPHEN IN SUBJECTS WITH
OA PAIN. A. Temple1, K. Cooper1 and G. Benson2.
1
McNeil Consumer & Specialty Pharmaceuticals,
Fort Washington, PA and 2Robert Wood Johnson
Medical School, Camden, NJ. Sponsor: M. Yuschak.
194
#1680
THE EFFECTS OF A DISSOCIATED
GLUCOCORTICOID RECEPTOR LIGAND
AND DEXAMETHASONE ON OSTEOCLAST
DIFFERENTIATION AND BONE
RESORPTION IN VITRO. H. Jarvelainen1, 2, K.
Nelo3, J. Ilvesaro3 and J. Tuukkanen3. 1AstraZeneca
R&D, Lund, Sweden, 2Department of Food and
Environmental Hygiene, University of Helsinki,
Helsinki, Finland and 3Department of Anatomy and
Cell Biology, University of Oulu, Oulu, Finland.
#1681
THERAPEUTIC EFFICACY AND SAFETY
OF UC-II, (-)-HYDROXYCITRIC ACID-SX,
HYDROXYCITRIC- GL, AND CHROMEMATE
IN ARTHRITIC DOGS. A. Peal1, R. C. Gupta1, A.
Curtsinger1, M. Alvey1, C. Simms1, M. D’Altilio1,
J. Goad1, T. Canerdy1, M. Bagchi2 and D. Bagchi2.
1
KY and 2InterHealth Nutraceuticals, Inc., Benicia,
CA.
#1682
SAFETY AND THERAPEUTIC EFFICAY
OF UNDENATURED TYPE II COLLAGEN
ALONE, AND IN COMBINATION WITH
GLUCOSAMINE AND CHONDROITIN IN
ARTHRITIC DOGS. M. D’Altilio1, R. C. Gupta1,
A. Peal1, A. Curtsinger1, M. Alvey1, C. Simms1,
T. Canerdy1, J. Goad1, M. Bagchi2 and D. Bagchi2.
1
KY and 2InterHealth Nutraceuticals Inc., Benicia,
CA.
#1683
SAFETY EVALUATION OF INTRAARTICULARLY INJECTED AMG 108 AND
KINERET IN NEW ZEALAND WHITE
RABBIT. A. Ndifor1, A. Nguyen1, T. Sun1, M.
Cosenza1, A. LaRochelle2 and J. Pletcher2. 1Amgen
Inc., Thousand Oaks, CA and 2Charles River
Laboratories, Worcester, MA.
#1684
THE HEPATIC EFFECTS OF SHORT TERM
DEXAMETHASONE ADMINISTRATION
IN RATS. E. R. Jackson, C. Kilroy, L. Correia,
B. Parzych, D. Joslin, I. Pruimboom-Brees, S.
Schomaker and D. Amacher. Safety Sciences, Pfizer,
Inc., Groton, CT.
#1685
DEPLETION OF MITOCHONDRIAL DNA IN
CARDIAC AND SKELETAL MUSCLE AFTER
IN UTERO EXPOSURE OF MICE TO AZT AND
AZT-CONTAINING COMBINATION ANTIRETROVIRAL THERAPIES. M. Myers1, 2, L. Von
Tungeln2, F. Beland2, 1 and R. Heflich2, 1. 1University
of Arkansas for Medical Sciences, Little Rock, AR
and 2National Center for Toxicological Research,
Jefferson, AR.
#1686
EFFECTS OF KETOCONAZOLE ON
MULTIDRUG RESISTANT-MEDIATED
TRANSPORT IN CACO-2 AND MDCKII-MDR1
DRUG TRANSPORT MODELS. Y. Fan1 and R.
R. Proteau1, 2. 1Pharmaceutical Sciences, Oregon
State University, Corvallis, OR and 2Enviromental
Corvallis, OR.
45th Annual
Meeting & ToxExpo
EVALUATION OF THE ANTIMICROBIAL
AND ANTIFUNGAL PROPERTIES OF
EBSELEN. G. Chan, D. Hardej and B. Billack.
Department of Pharmaceutical Sciences, St. John’s
University, Queens, NY.
#1688
EVALUATION OF PLURONIC®F127BASED VEHICLES FOR DRUG DELIVERY
BY ASSESSING STIMULATION AND
INHIBITION OF HEMATOPOIETIC
PROGENITOR PROLIFERATION WITH IN
VITRO COLONY ASSAYS. J. M. Blonder1, W.
Schauer1, A. Samaniego1, J. Damen2, E. Clarke2 and
G. J. Rosenthal1. 1RxKinetix, Louisville, CO and
2
StemCell Technologies, Vancouver, BC, Canada.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: INHALATION METHODS AND DOSIMETRY
Chairperson(s): Owen Moss, CIIT Centers for Health Research, Research
Triangle Park, NC.
#1689
DIETARY SUBCHRONIC TOXICITY AND
TERATOLOGY STUDIES AVICEL CL-611®
IN SPRAGUE-DAWLEY RATS. D. Nuber1, C.
Freeman2 and M. Weiner1. 1FMC Corporation,
Princeton, NJ and 2Formerly of FMC Corporation,
Princeton, NJ.
#1690
REPEATED SUBCUTANEOUS DOSE
TOXICITY STUDY OF DM401 IN MICE. W. S.
Koh1, W. H. Choi1, Y. B. Kim1, C. S. Ha1, H. Lee2,
Y. D. Kwon3, O. M. Choi3, K. A. Cheong3 and Y. J.
Lee3. 1Korea Institute of Toxicology, Daejeon, South
Korea, 2Samsung Medical Center, Seoul, South
Korea and 3MEDIPOST, Seoul, South Korea.
#1691
SYSTEMIC EFFECT OF VACUUM-ASSISTED
CLOSURE (V.A.C.®) THERAPY FOR 8 DAYS
IN SWINE WITH CUTANEOUS WOUNDS.
K. C. Norbury1, M. Piacente2, R. Zirl3, B. Stouch1
and K. Kieswetter1. 1Kinetic Concepts, Inc., San
Antonio, TX, 2Biological Test Center, Irvine, CA and
3
Tejas Pathology, Tomball, TX.
#1692
INVESTIGATION OF THE HEPATOTOXICITY
OF USNIC ACID USING A COMPENDIUM OF
RAT LIVER GENE EXPRESSION PROFILES.
P. D. Cornwell1, A. T. De Souza1, G. Slatter1, J. C.
Rockett1, M. J. Caguyong1, O. Cheng2, X. Dai2, Y.
D. He2 and R. G. Ulrich1. 1Preclinical Molecular
Profiling, Rosetta Inpharmatics LLC (a wholly
owned subsidiary of Merck & Co. Inc.), Seattle,
WA and 2Bioinformatics, Rosetta Inpharmatics LLC
(a wholly owned subsidiary of Merck & Co. Inc.),
Seattle, WA.
#1693
#1694
NON-INVASIVE ASSESSMENT OF
PULMONARY DISORDER USING
COMPUTED TOMOGRAPHY (CT)-IMAGING
IN A NON-HUMAN PRIMATE. N. Horai1, T.
Bando1, H. Kasai1, S. Nagayama1, H. Tokado1, K.
Fukuzaki1, K. Abeyama2 and R. Nagata1. 1Shin
Nippon Biomedical Laboratories, Ltd., Kagoshima,
Japan and 2Department of Preventive Medicine,
Kagoshima University Graduated School of
Medicine and Dental Science, Kagoshima, Japan.
#1695
THE ASSESSMENT OF RESPIRATORY
PARAMETERS IN DOGS USING A NON–
INVASIVE SPIROMETRY SYSTEM. H.
Campbell, D. Poulin, A. Viau and C. Banks.
#1696
MEASUREMENT AND PREDICTION
OF JUVENILE BEAGLE RESPIRATORY
PARAMETERS FOR USE IN INHALATION
DOSIMETRY ESTIMATES. J. Weinberg and D.
T. Kirkpatrick. WIL Research Laboratories, LLC,
Ashland, OH.
#1697
THREE MINUTE INHALATION OF
METHACHOLINE BY B6C3F1 OR BALB/C
FEMALE MICE PRODUCES NO CHANGE IN
PRESSURE DROP ACROSS THE ISOLATED
UPPER RESPIRATORY TRACT. O. R. Moss
and E. W. Tewksbury. Computational Biology, CIIT
Centers for Health Resesrch, Research Triangle
Park, NC.
#1698
PARTICLE DEPOSITION IN
SPONTANEOUSLY HYPERTENSIVE
(SH) RATS EXPOSED VIA WHOLE-BODY
INHALATION: MEASURED VS. ESTIMATED
DOSE. L. B. Wichers1, W. H. Rowan2, J. P. Nolan2,
A. D. Ledbetter2, J. K. McGee2, D. L. Costa2 and
W. P. Watkinson2. 1Environmental Sciences and
Hill, NC and 2ORD/NHEERL/ETD/PTB, U.S. EPA,
#1699
RABBIT EMBRYO-FOETAL INHALATION
STUDIES - MAXIMISING OF DOSING
POTENTIAL. S. A. Moore and C. J. Hardy.
Inhalation Toxicology, Huntingdon Life Sciences
Ltd., Huntingdon, United Kingdom.
#1700
A REFINED METHOD OF RESTRAINT FOR
DOGS USED IN INHALATION STUDIES. M.
M. Hussain, A. C. Leach and C. J. Hardy. Inhalation
Toxicology, Huntingdon Life Sciences Ltd.,
EFFECTS OF HERBA AGRIMONIA ON
CHEMICAL-INDUCED LIVER TUMOR IN
RATS. J. W. Ho and J. Song. Biochemistry, The
Chinese University of Hong Kong, HK, Hong Kong.
195
WEDNESDAY
#1687
45th Annual
Meeting & ToxExpo
#1701
SATURATION OF AIRWAY EPITHELIUM
AFTER MODERATE EXPOSURES TO
LIPOPHILIC CARCINOGENS: ONE
CULPRIT BEHIND NEGATIVE INHALATION
EXPOSURES IN LABORATORY ANIMALS?
P. Gerde. NIEM, Karolinska Institutet, Stockholm,
Sweden.
#1702
ELECTROSTATIC PRECIPITATION AS AN
ALTERNATIVE METHOD FOR IN VITRO
EXPOSURES TO MIXTURES OF GASES
AND PARTICLES. K. de Bruijne1, S. Lake1, K. G.
Sexton1, M. Doyle1, S. Ebersviller1, H. Jeffries1, D.
Leith1 and I. Jaspers2, 1. 1ENVR, UNC-CH, Chapel
Hill, NC and 2CEMALB, UNC-CH, Chapel Hill,
NC.
#1703
DEVELOPMENT OF NOVEL DIESEL
EXHAUST PARTICLE AEROSOL
GENERATION AND DEPOSITION METHODS
FOR IN VITRO TOXICOLOGY STUDIES.
D. Cooney1 and A. J. Hickey2, 1. 1Biomedical
Hill, NC and 2School of Pharmacy, University of
#1704
INTRATRACHEAL INSTILLATION OF
BLEOMYCIN TO CONSCIOUS MICE VIA
TRACHEOTOMY TUBE. H. Goto1, T. Senba1, H.
Ueda1, Y. Shimomura1, N. Ishiharada1, T. Tahara1,
N. Takahashi1, K. Morishita1 and L. L. Lanning2.
1
Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan
and 2Otsuka Maryland Research Institute, Rockvill,
MD.
#1705
A HIGHLY SENSITIVE AND ROBUST
METHOD FOR THE DETERMINATION
OF ACROLEIN AND OTHER TOXIC
CARBONYLS IN AIR. V. Seaman1 and T. M.
Cahill1. 1Environmental Toxicology, UC Davis,
Davis, CA and 2Environmental Toxicology, UC
Davis, Davis, CA.
#1707
INHIBITION OF ACUTE
LIPOPOLYSACCHARIDE TOXICITIES IN
RATS BY 3<IH>, -1, 2-DITHIOLE-3-THIONE.
A. R. Karuri1. 1Biology, University of Memphis,
Memphis, TN, 5Pharmacology and Toxicology,
Dartmouth Medical school, Hanover, NH,
6
Environmental Health Sciences, John Hopkins
Bloomber School of Public Health, Baltimore, MD
and 7Biology, University of Memphis, Memphis, TN.
Sponsor: T. Sutter.
#1708
LPS COTREATED RATS AS A MODEL
FOR TROVAFLOXACIN-INDUCED
IDIOSYNCRATIC HEPATOTOXICITY. J.
F. Waring1, M. J. Liguori1, J. P. Luyendyk2, J. F.
Maddox2, P. E. Ganey2, R. F. Stachlewitz1, C. North2,
E. A. Blomme1 and R. A. Roth2. 1Cellular and
Molecular Toxicology, Abbott Laboratories, Abbott
Park, IL and 2Department of Pharmacology and
Toxicology, Michigan State University, Lansing, MI.
#1709
ANALYSIS OF LPS/TNF SIGNAL IN
THE HEPATOTOXICITY OF VARIOUS
CHEMICALS IN THE DATABASE OF
TOXICOGENOMICS PROJECT IN JAPAN.
Y. Mizukawa1, 2, A. Ono2, T. Miyagishima2, T.
Urushidani1, 2 and T. Nagao3. 1Department of
Pathophysiology, Faculty of Pharmaceutical
Sciences, Doshisha Women’s College, Kyoto, Japan,
2
Toxicogenomics Project, National Institute of
Biomedical Innovation, Osaka, Japan and 3National
Institute of Health Sciences, Tokyo, Japan. Sponsor:
T. Inoue.
#1710
COAGULATION-DEPENDENT GENE
EXPRESSION AND INJURY IN LIVERS OF
RATS GIVEN LIPOPOLYSACCHARIDE WITH
RANITIDINE BUT NOT WITH FAMOTIDINE.
J. P. Luyendyk1, L. D. Lehman-McKeeman2, D.
M. Nelson2, V. M. Bhaskaran2, T. P. Reilly3, B. D.
Car2, G. H. Cantor2, J. F. Maddox1, P. E. Ganey1
and R. A. Roth1. 1Department of Pharmacology and
Toxicology, National Food Safety and Toxicology
Center, Center for Integrative Toxicology, Michigan
State University, East Lansing, MI, 2Discovery
Toxicology, Bristol-Myers Squibb, Princeton, NJ
and 3Drug Safety Evaluation, Bristol-Myers Squibb,
Syracuse, NY.
#1711
MODEST INFLAMMATION ENHANCES
DICLOFENAC HEPATOTOXICITY IN RATS:
A POTENTIAL ANIMAL MODEL FOR
IDIOSYNCRATIC DRUG REACTION. X. Deng1,
R. F. Stachlewitz2, M. J. Liguori3, E. A. Blomme3, J. F.
Waring3, J. P. Luyendyk1, J. F. Maddox1, P. E. Ganey1
and R. A. Roth1. 1Department of Biochemistry and
Molecular Biology, Department of Pharmacology
Lansing, MI, 2Department of Discovery Safety,
Metabolism and Pharmacokinetics, Abbott
Bioresearch Center, Worcester, MA and 3Department
of Molecular and Cellular Toxicology, Abbott
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: LIVER I
Chairperson(s): Jeffrey Laskin, University of Medicine and Dentistry of
New Jersey, Piscataway, NJ and Brian Day, National Jewish Medical &
Research Center, Denver, CO.
#1706
WEDNESDAY
REGULATION OF INFLAMMATORY
MEDIATOR PRODUCTION IN THE LIVER
DURING ACUTE ENDOTOXEMIA. L. C.
Chen, D. L. Laskin and J. D. Laskin. Joint Graduate
Program in Toxicology, Rutgers University and
UMDNJ-Robert Wood Johnson Medical School,
Piscataway, NJ.
196
45th Annual
Meeting & ToxExpo
#1713
#1714
#1715
#1716
#1717
LEFLUNOMIDE IS A POTENT INHIBITOR
OF THE MITOCHONDRIAL PERMEABILITY
TRANSITION PORE IN HEPATOCYTES. C.
Latchoumycandane1, Q. Seah1, J. Sattabongkot2,
W. Beerheide3 and Universtiy of. A. Boelsterli1,
4 1
. Pharmacology, NUS, Singapore, Singapore,
2
AFRIMS, Bangkok, Thailand, 3Siam Life Science,
Pathumthani, Thailand and 4Pharmacy, NUS,
Singapore, Singapore.
MITOCHONDRIAL ADENINE NUCLEOTIDE
TRANSLOCATOR EXPRESSION IS
DECREASED IN LIVER CELLS OF ZUCKER
FATTY RATS: RELEVANCE FOR ALTERED
MITOCHONDRIAL BIOENERGETICS IN
STEATOSIS. J. Teodoro, A. P. Rolo, P. J. Oliveira
and C. M. Palmeira. Center for Neurosciences and
Cell Biology, Department of Zoology, University of
Coimbra, Coimbra, Portugal.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: IN VITRO IMMUNOTOXICITY
Chairperson(s): Stephen Bloom, Cornell, Ithaca, NY and Emanuela
Corsini, University of Milan, Milan, Italy.
MITOCHONDRIAL ANTIOXIDANT
STATUS AND NUCLEOSIDE REVERSE
TRANSCRIPTASE INHIBITOR (NRTI)
ASSOCIATED TOXICITY. H. Leitner1, 2 and B.
Day2, 1. 1Toxicology, UCHSC, SOP, Denver, CO and
2
Medicine, NJMRC, Denver, CO.
GOVERNING GLOBAL MITOCHONDRIAL
FUNCTION THROUGH REGULATION OF
VOLTAGE-DEPENDENT ANION CHANNELS
(VDAC): IMPLICATIONS FOR PHYSIOLOGY
AND TOXICOLOGY. J. J. Lemasters and E. L.
Holmuhamedov. Cell & Developmental Biology,
University of North Carolina at ChapelHill, Chapel
Hill, NC.
MITOCHONDRIAL F1-ATP SYNTHASE:
NO FUNCTIONAL CONSEQUENCES
OF RNA INTERFERENCE-MEDIATED
GENE SILENCING IN HEPG2. C. Strupp1, F.
Straube1, O. Grenet1, W. E. Trommer2 and A. Wolf1.
1
Biomarker Development, Novartis Pharma AG,
Basel, Switzerland and 2Department of Chemistry,
University of Kaiserslautern, Kaiserslautern,
Germany.
MITOCHIP: AN OLIGONUCLEOTIDE
MICROARRAY AS A GENOMIC TOOL
TO UNDERSTAND NRTI-INDUCED
MITOCHONDRIAL DYSFUNCTION IN THE
MOUSE LIVER. V. Desai1, C. L. Moland1, W.
S. Branham1, T. Lee2, R. R. Delongchamp2, J. E.
Leakey3 and J. C. Fuscoe1. 1Center for Functional
Genomics, Division of Systems Toxicology, NCTR,
Jefferson, AR, 2Division of Biometry and Risk
Assessment, NCTR, Jefferson, AR and 3Office of
Scientific Co-ordination, NCTR, Jefferson, AR.
197
#1718
KUPFFER CELL/HEPATOCYTE
COCULTURE AS A MODEL TO ASSESS
XENOBIOTIC-INFLAMMATION
INTERACTIONS. F. F. Tukov1, J. F. Maddox1,
D. E. Amacher2, R. A. Roth1 and P. E. Ganey1.
1
Pharmacology & Toxicology, Michigan State
University, East Lansing, MI and 2Safety Sciences
Groton, Pfizer Inc., Groton, CT.
#1719
SUPPRESSION OF NITRIC OXIDE
PRODUCTION AND INDUCIBLE NITRIC
OXIDE SYNTHASE EXPRESSION BY
NATURALLY OCCURRING SMALL
MOLECULES IN LPS-STIMULATED
RAW264.7 CELLS. S. Yea1, 2, C. Choi1, 2, D. Seog1
and Y. Park1. 1Department of Biochemistry, College
of Medicine, Inje University, Busan, Korea, South
Korea and 2Biohealth Product Research Center, Inje
University, Busan, Korea, South Korea. Sponsor: H.
Kim.
#1720
INHIBITION OF LIPOPOLYSACCHARIDE
STIMULATED PHAGOCYTIC ACTIVITY
OF RAT PERITONEAL MACROPHAGES BY
METHYL PAMITATE. S. sarkar, M. Khan, B. S.
Khaphalia and S. G. Ansari. Pathology, University of
Texas of Medical Branch, Galveston, TX.
#1721
IN VITRO PRO-INFLAMMATORY EFFECTS
OF NICOTINE AND A TOBACCO-SPECIFIC
NITROSAMINE ON HUMAN LUNG
ALVEOLAR CELL LINE A549 AND HUMAN
MACROPHAGE CELL LINE U937. S. F. Yee
and R. D. Leverette. Lorillard Tobacco Company,
Greensboro, NC.
#1722
IN VITRO INHIBITION OF SUBSTANCE P
ON IL-1 RELEASE FROM ALVEOAR CELLS
IN RESPONSE TO JP-8 JET FUEL. N. N. Sun,
C. Nardi, S. S. Wong and M. L. Witten. Pediatrics,
#1723
IN VITRO TOXICOLOGY OF ALUMINUM
NANOPARTICLES IN RAT LUNG
MACROPHAGES. A. J. Wagner1, 2, S. Hussain2,
K. Hess3, C. Bleckmann1, E. England1 and J.
J. Schlager2. 1Air Force Institue of Technology,
Wright-Patterson AFB, OH, 2Applied Biotechnology
Branch, Human Effectiveness Directorate, Air Force
Research Laboratory, Wright-Patterson AFB, OH
and 3Geo-Center Inc., Wright-Patterson AFB, OH.
WEDNESDAY
#1712
45th Annual
Meeting & ToxExpo
#1724
ARSENIC IDUCED GROWTH ARREST AND
APOPTOSIS IN MOUSE B CELL LINES. S.
C. Pelsue, D. Swett, A. Curtis and C. Sczymczuk.
Maine Center of Toxicology & Environmental
Health, University of Southern Maine, Portland, ME.
Sponsor: J. Wise.
#1725
MODULATION OF THE 3’
IMMUNOGLOBULIN HEAVY CHAIN
REGULATORY REGION BY REACTIVE
OXYGEN SPECIES. E. J. Romer, D. C. Ranatunga
and C. E. Sulentic. Pharmacology & Toxicology,
Wright State University, Dayton, OH.
#1726
GW7845, A PPARγ AGONIST, INDUCES
CALCIUM-DEPENDENT MAP KINASE
ACTIVATION AND APOPTOSIS IN PRO/PREB CELLS. J. Schlezinger, S. Bissonnette and D. H.
Sherr. Environmental Health, Boston University
School of Public Health, Boston, MA.
#1727
BYPASS OF BCL-2-MEDIATED DRUG
RESISTANCE IN A NEWLY DERIVED
HUMAN B-LYMPHOID CELL LINE. S. E.
Bloom and D. E. Muscarella. Microbiology and
Immunology, Cornell University, Ithaca, NY.
#1728
DIFFERENTIAL ADHESION OF HUMAN BCELL LINES TO FOLLICULAR DENDRITIC
CELLS AND SUBSEQUENT MODULATION
OF CHEMICALLY INDUCED APOPTOSIS.
D. Muscarella and S. Bloom. Microbiology and
Immunology, Cornell University, Ithaca, NY.
#1729
#1734
IL-12 PRODUCTION BY DCS ACTIVATED
WITH NISO4. S. Kerdine-Roemer, D. Antonios, A.
Larange, D. Lecoeuche and M. Pallardy. INSERM
UMR-S 461, Faculty of Pharmacy, ChatenayMalabry, France.
#1735
IMMUNOTOXIC POTENTIAL OF
ACRYLONITRILE IN HUMAN LEUKOCYTES
AND T84 HUMAN COLONIC EPITHELIAL
CELLS - IN VITRO STUDIES. M. Y. Farooqui1,
A. R. Abd-Allah2 and A. E. Ahmed3. 1Biology,
University of Texas Pan American, Edinburg, TX,
2
Pharmacology and Toxicology, Al-Azhar University,
Cairo, Egypt and 3Pathology, University of Texas
Medical Branch, Galveston, TX.
#1736
IMMUNOMODULATION OF MURRAY
COD (MACCULLOCHELLA PEELI)
HEAD KIDNEY CELL FUNCTIONS BY
CYLINDROSPERMOPSIN. P. F. Wright1, A. J.
Harford1, C. Haskard2 and K. O’Halloran3. 1Key
Centre for Toxicology, RMIT-University, Bundoora,
Melbourne, VIC, Australia, 2Australian Water
Quality Centre, Bolivar, Adelaide, SA, Australia
and 3CENTOX, Landcare Research, Lincoln, New
Zealand. Sponsor: P. Di Marco.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: METHODS IN IMMUNOTOXICITY
EFFECTS OF TCDD ON LPS-INDUCED
CHANGES IN MARKERS OF B CELL
DIFFERENTIATION. D. Shnaider and N. E.
Kaminski. Center for Integrative Toxicology and
the Department of Pharmacology and Toxicology,
Chairperson(s): Thomas Kawabata, Pfizer, Groton, CT and Lynne
LeSauteur, CTBR, Senneville, QC, Canada.
#1730
PROTEIN INTERACTIONS AT THE DRE
AND κB MOTIFS WITHIN THE 3’ IgH
REGULATORY REGION. C. E. Sulentic, E.
J. Romer and D. C. Ranatunga. Pharmacology &
Toxicology, Wright State University, Dayton, OH.
#1731
MODULATION OF THE 3’IgH REGULATORY
REGION BY STRUCTURALLY DIVERSE
CHEMICALS THAT ACTIVATE THE AHR
SIGNALING PATHWAY. R. A. Henseler and C. E.
Sulentic. Pharmacology & Toxicology, Wright State
WEDNESDAY
#1732
CHARACTERIZATION OF THE
IMMUNOSUPPRESSIVE ACTIVITY OF
THE PLANT-DERIVED CANNABINOID,
CANNABIDIOL. B. L. Kaplan and N. E. Kaminski.
Center for Integrative Toxicology and Department
of Pharmacology and Toxicology, Michigan State
#1733
BETAIN PREVENTS 4-HYDROXYNONENALINDUCED CYTOTOXICITY IN CD4+ T
LYMPHOCYTES. W. Chang1, S. S. Barve2, 1, C.
J. McClain2 and T. S. Chen1. 1Pharmacology &
Toxicology, University of Louisville, Louisville, KY
and 2Medicine, University of Louisville, Louisville,
KY.
198
#1737
EVALUATION OF INTER-ANIMAL
VARIABILITY IN THE T-CELL DEPENDENT
ANTIBODY RESPONSE IN RATS. J. R. Piccotti1,
J. D. Alvey1, R. M. Slim1, D. L. Morris2 and T. T.
Kawabata3. 1Worldwide Safety Sciences, Pfizer
Inc., Ann Arbor, MI, 2Worldwide Safety Sciences,
Pfizer Inc., Chesterfield, MO and 3Worldwide Safety
Sciences, Pfizer Inc., Groton, CT.
#1738
DETERMINATION OF OPTIMUM
NUMBER OF RATS NEEDED TO
ASSESS IMMUNE COMPETENCE
BY PRODUCTION OF ANTIBODY TO
KEYHOLE LIMPET HEMOCYANIN
FOLLOWING ORAL ADMINISTRATION
OF CYCLOPHOSPHAMIDE. H. V. Ratajczak,
B. Jin, K. Blanchard and S. Jayadev. Toxicology,
Boehringer Ingelheim Pharmaceuticals, Inc.,
Ridgefield, CT.
#1739
VALIDATION OF A T-CELL DEPENDENT
ANTIBODY RESPONSE IN CYNOMOLGUS
MONKEYS (INDONESIAN ORIGIN) USING
KEYHOLE LIMPET HEMOCYANIN (KLH). J.
De Gagne, N. Rouleau, N. Cristiano, S. A. Kirk and
L. LeSauteur. Immunology, Laboratory Sciences,
45th Annual
Meeting & ToxExpo
#1740
A VALIDATION STUDY OF AN IN VIVO
DELAYED-TYPE HYPERSENSITIVITY
(DTH) MODEL IN RHESUS MONKEYS. C.
M. Satterwhite1, C. M. Brodmerkel2, K. Vaddi2,
L. E. Black1 and P. B. Lappin1. 1Charles River
Laboratories, Preclinical Services, Sparks, NV and
2
Incyte Corporation, Wilmington, DE.
#1741
OPTIMIZATION OF AN IN VITRO NATURAL
KILLER (NK) CELL ACTIVITY ASSAY IN
CYNOMOLGUS MONKEYS. E. Rechetnik, C.
M. Satterwhite, L. E. Black and P. B. Lappin. Charles
River Laboratories, Preclinical Services, Sparks, NV.
#1742
ASSESSMENT OF NK CELL ACTIVITY
IN THE RAT USING FLOW CYTOMETRY.
F. Condevaux1, J. Guichard1, F. Horand1 and J.
Descotes2. 1MDS Pharma Services, St Germain s/
L’Arbresle, France and 2Poison Center, Lyon, France.
#1743
ANALYTICAL VALIDATION
OF A PERIPHERAL BLOOD
IMMUNOPHENOTYPING ASSAY FOR RATS.
R. Caldwell, J. Fishel and P. Marshall. Toxicology,
Covance Laboratories, Madison, WI.
#1750
GENE EXPRESSION ALTERATIONS IN
IMMUNE SYSTEM PATHWAYS FOLLOWING
EXPOSURE TO IMMUNOSUPPRESSIVE
CHEMICALS. R. Patterson1, N. Walker1, K. White,
Jr.2, R. Brown2, D. Musgrove2, S. Harrison1 and D.
Germolec1. 1NIEHS, Research Triangle Park, NC
and 2Virginia Commonwealth University, Richmond,
VA.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: NEUROTOXICITY: METALS—MANGANESE
Chairperson(s): Donald Smith, University of California - Santa Cruz,
Santa Cruz, CA and Ronald Tjalkens, Colorado State University, Fort
Collins, CO.
BIOMARKERS FOR DRUG-INDUCED
STRESS: CORTICOSTERONE-INDUCED
CHANGES IN GENE EXPRESSION IN
WHOLE BLOOD. P. Hebert1, S. B. Pruett1, M.
Lawton2, J. Lapointe2 and K. T. Thomas2. 1Cellular
Shreveport, LA and 2Safety Sciences, Pfizer, Inc.,
Groton, CT.
#1745
MEASUREMENT OF EX VIVO CYTOKINE
RELEASE BY HUMAN AND CYNOMOLGUS
MONKEY WHOLE BLOOD CULTURES
USING CYTOKINE BEAD ARRAYS. M. Wing,
D. Lanham, A. Michel and S. Watts. Experimental
Biology, Huntingdon Life Sciences Ltd., Cambs,
United Kingdom. Sponsor: D. Steve.
#1746
EVALUATION OF DRUG-INDUCED
ALTERATIONS IN LYMPHOID TISSUES
BY LASER SCANNING CYTOMETRY. J. A.
Wijsman, L. A. Obert, J. R. Piccotti, R. E. Guzman
and R. W. Dunstan. Safety Sciences Michigan,
Pfizer, Ann Arbor, MI.
#1747
CRYO TISSUE MICRO ARRAYS – A NOVEL
APPROACH TO HIGH THROUGHPUT
THERAPEUTIC BIOPHARMACEUTICAL
SCREENING. A. Postoyalko. Covance Laboratories
Ltd., Harrogate, United Kingdom. Sponsor: D.
Everett.
#1748
VALIDATION OF A SEMI-QUANTITATIVE
BIOASSAY WITH AN ELISA ENDPOINT
FOR THE DETECTION OF NEUTRALIZING
ANTI-PROTEIN-X ANTIBODIES IN HUMAN
SERUM. G. Pinard1, M. Poirier1, B. Ruelland1,
H. Harouchi1, L. LeSauteur1, D. Finco-Kent2, X.
Guo2 and T. Kawabata2. 1Immunology Laboratory
Sciences, Charles River Laboratories Preclinical
Montréal, Senneville, QC, Canada and 2Safety
Sciences, Immunotoxicology Laboratory, Pfizer
Global R&D, Groton, CT.
DISTINCTIVE GENE EXPRESSION
PATTERNS IN THYMUSES EXPOSED TO
ATROPHY-INDUCING CHEMICALS. K.
Nohara1, K. Ao1, Y. Miyamoto1, C. Tohyama2, T.
Kobayashi1, H. Sato3 and T. Ito1. 1National Institute
for Environmental Studies, Tsukuba, Japan,
2
CDBIM, University of Tokyo, Tokyo, Japan and
3
IMMD, Tokyo, Japan.
199
#1751
OLFACTORY TRANSPORT OF MANGANESE
TO THE BRAIN IS ENHANCED BY ANEMIA
AND INVOLVES DIVALENT METAL
TRANSPORTER-1. K. Thompson1, 2, R. Molina2,
T. Donaghey2, J. Brain2 and M. Wessling-Resnick1.
1
Genetics and Complex Diseases, Harvard School
of Public Health, Boston, MA and 2Environmental
Health, Harvard School of Public Health, Boston,
MA.
#1752
TISSUE DISTRIBUTION OF MANGANESE
IN IRON SUFFICIENT OR IRON DEFICIENT
RATS AFTER STAINLESS STEEL WELDINGFUME EXPOSURE. J. D. Park1, E. S. Park2, K. Y.
Kim1, D. W. Kim1, S. J. Choi1, Y. H. Chung3, J. H.
Sung3, J. H. Han3, J. S. Lee3 and I. J. Yu3. 1Preventive
Medicine, Chung-Ang University, Seoul, South
Korea, 2Pathology, Chung-Ang University, Seoul,
South Korea and 3Laboratory of Occupational
Toxicology, Chemical Safety & Health Research
Center, Occupational Safety & Health Research
Institute, KOSHA, Daejeon, South Korea.
#1753
EFFECT OF DOPAMINE TRANSPORTER
BLOCKADE ON DIETARY IRON/
MANGANESE INTERACTIONS IN THE
DEVELOPING MALE RAT BRAIN. K. Erikson
and J. Anderson. Nutrition, The University of North
Carolina Greensboro, Greensboro, NC.
WEDNESDAY
#1744
#1749
45th Annual
Meeting & ToxExpo
#1754
SUBCELLULAR REDISTRIBUTION OF IRON
RESPONSE ELEMENT (IRE)-CONTAINING
TRANSPORTERS IN INTACT RAT CHOROID
PLEXUS FOLLOWING EXPOSURE TO
INORGANIC Mn OR Fe. X. Wang1, D. S. Miller2
and W. Zheng1. 1Health Sciences, Purdue University,
West Lafayette, IN and 2NIH/NIEHS, Research
Triangle Park, NC.
#1755
DETERMINATION OF BRAIN MANGANESE
ACCUMULATION USING MAGNETIC
RESONANCE IMAGING (MRI) AND ATOMIC
ABSORPTION SPECTROSCOPY. N. Zhang1,
V. A. Fitsanakis2, J. G. Anderson3, K. M. Erikson3,
J. C. Gore1, 5, M. J. Avison1 and M. Aschner2, 4,
5 1
. Radiology, Vanderbilt University Institute of
Imaging Science, Nashville, TN, 2Pediatrics,
Vanderbilt University Med. Ctr, Nashville,
TN, 3Nutrition, University of North CarolinaGreensboro, Greensboro, NC, 4Pharmacology,
Vanderbilt University Med. Ctr, Nashville, TN
and 5Kennedy Ctr, Vanderbilt University Med. Ctr,
Nashville, TN.
#1756
#1757
OXIDATIVE STRESS AND IMPAIRED
ENERGY METABOLISM AFTER EXPOSURE
TO MANGANESE. V. A. Fitsanakis1, D. Milatovic1,
R. C. Gupta2 and M. Aschner1, 3, 4. 1Pediatrics,
Vanderbilt University Medical Center, Nashville,
TN, 2Murray State University, Hopkinsville, KY,
3
Pharmacology, Vanderbilt University Med. Ctr,
Nashville, TN and 4The Kennedy Center, Vanderbilt
University Med. Ctr, Nashville, TN.
MN SELECTIVELY ALTERS THE
EXPRESSION OF A SUBSET OF GENES LIKE
THOSE ENCODING PROINFLAMMATORY
FUNCTIONS IN PRIMARY HUMAN
ASTROCYTES. S. M. Mense1, C. Lan1, A.
Sengupta1, M. Zhou1, G. Bentsman2, D. J. Volsky2, J.
H. Graziano1 and L. Zhang1. 1Environmental Health
Sciences, Columbia University, New York and
2
Molecular Virology Division, Columbia University,
New York.
WEDNESDAY
#1758
TIME COURSE OF P38-ALPHA
PHOSPHORYLATION IN N9 MICROGLIAL
CELLS FOLLOWING EXPOSURE TO
MANGANESE IN VITRO. P. L. Crittenden and N.
M. Filipov. CEHS, Basic Sciences, Mississippi State
University, Mississippi State, MS.
#1759
MANGANESE POTENTIATES NFκBDEPENDENT EXPRESSION OF INOS
THROUGH ACTIVATION OF β1 INTEGRIN
AND ERK. J. A. Buffington, W. Liu and R. B.
Tjalkens. Environmental and Radiological Health
Sciences, Colorado State University, Ft. Collins, CO.
#1760
ASTROGLIOSIS AND OVEREXPRESSION
OF INDUCIBLE NITRIC OXIDE SYNTHASE
(NOS2) CORRELATE WITH NEURONAL
INJURY IN A MOUSE MODEL OF
MANGANESE NEUROTOXICITY. K. A.
Sullivan1, X. Liu2 and R. B. Tjalkens1. 1Colorado
State University, Fort Collins, CO and 2Texas A&M
200
#1761
MANGANESE SUPPRESSES THE
PROPAGATION OF INTERCELLULAR
CALCIUM WAVES IN ASTROCYTE
NETWORKS THROUGH ALTERATION OF
MITOCHONDRIAL CALCIUM DYNAMICS.
B. Mohl1, R. Mouneimne2, M. Zoran3 and R.
B. Tjalkens1. 1Environmental and Radiological
Health Sciences, Colorado State University, Ft.
Collins, CO., 2Integrative Biosciences, Texas A&M
University, College Station, TX and 3Biology, Texas
#1762
EFFECT OF PB, MN AND PB/MN METAL
MIXTURES ON RAT HIPPOCAMPAL
NEURON viaBILITY. R. R. Reams1 and A.
P. Stephenson1. 1College Of Pharmacy, Florida
A&M University, Tallahassee, FL and 2College of
Pharmacy, Florida A&M University, Tallahassee, FL.
#1763
EFFECTS OF MANGANESE CHLORIDE
ON 3 ISOFORMS OF DIVALENT METAL
TRANSPORTER KNOCKOUTS IN
CAENORHABDITIS ELEGANS. C. Au1, J.
G. Anderson2, K. M. Erikson2, R. Nass3 and M.
Aschner4. 1Center of Molecular Neuroscience,
Vanderbilt University Med. Ctr., Nashville, TN,
2
Department of Nutrition, University of North
Carolina-Greensboro, Greensboro, NC, 3Department
of Anaesthesiology, Vanderbilt University, Nashville,
TN and 4Department of Pediatrics, Vanderbilt
University Med. Ctr., Nashville, TN.
#1764
DISRUPTION OF TRANSFERRIN RECEPTOR
PROCESSING BY LOW LEVEL MANGANESE
EXPOSURE. M. Braun-Sommargren, D. Crooks
and D. R. Smith. Environmental Toxicology,
University of California, Santa Cruz, CA.
#1765
NEUROTOXICITY OF NEONATAL
MANGANESE EXPOSURE: PERSISTENCE
OF EFFECTS AND SUSCEPTIBILITY TO
OTHER AGENTS. C. Kern, R. Gwiazda and D.
Smith. ETOX, UCSC, Santa Cruz, CA.
#1766
EFFECT OF DIVALENT METALS
MANGANESE AND CADMIUM ON
UBIQUITIN-PROTEASOME FUNCTION
AND PROTEIN AGGREGATION IN CELL
CULTURE MODELS OF PRION DISEASE:
POSSIBLE ROLE OF METALS IN PRION
DISEASE PATHOGENESIS. C. J. Choi, V.
Anantharam, A. Kanthasamy and A. G. Kanthasamy.
Biomedical Sciences, Iowa State University, Ames,
IA.
45th Annual
Meeting & ToxExpo
#1767
EFFECTIVE TREATMENT OF MANGANESEINDUCED OCCUPATIONAL PARKINSONISM
WITH P-AMINOSALICYLIC ACID (PAS-NA):
A CASE OF 17-YEAR FOLLOW-UP STUDY.
Y. Jiang1, X. Mo2, F. Du2, H. Gao3, J. Xie4, F. Lia4,
E. Pira5 and W. Zheng6. 1Department Occup Health
Toxicol, Guangxi Medical University, Nanning,
Guangxi, China, 2Department of Neurology,
Guangxi Medical University, Nanning, Guangxi,
China, 3Wuzhou Center for Disease Prevention
and Control, Wuzhou, Guangxi, China, 4Wuzhou
Worker’s Hospital, Wuzhou, Guangxi, China,
5
Department of T.O. & Occup Health, University of
Turin, Turin, Italy and 6School of Health Sciences,
Purdue University, West Lafayette, IN.
#1772
ZINC ATTENUATES CADMIUM-INDUCED
MODULATION OF CHOLINE TRANSPORT
IN CULTURED CHOROID PLEXUS. A. R.
Villalobos and J. Tay. University of Rochester,
Rochester, NY.
#1773
BRAIN TRANSPORT AND DISTRIBUTION
OF COPPER AS AFFECTED BY SYSTEMIC
IRON STATUS. B. Choi1 and W. Zheng2. 1College
of Medicine, Chung-Ang University, Seoul, South
Korea and 2School of Health Sciences, Purdue
#1774
THE EFFECTS OF CUPRIC
DIMETHYLDITHIOCARBAMATE ON
MATERNAL AND FETAL LONG-EVANS
RATS. B. Scharf1 and L. D. Trombetta2, 1. 1Biological
Sciences, St. John’s University, New York and
2
Pharmaceutical Sciences, St. John’s University,
Jamaica, NY.
#1775
METHYLMERCURY ALTERS GLUTAMINE
HOMEOSTASIS IN ASTROCYTES. M. Aschner1,
Z. Yin1, O. Soldin2 and T. Syversen3. 1Pediatrics,
TN, 2Medicine, Georgetown University, Washington,
DC and 3Clinical Neuroscience, Norwegian
University of Science and Technology, Trondheim,
Norway.
#1776
METHYLMERCURY EXPOSURE IN VITRO
INCREASES SOLUBLE gp130 RECEPTOR, A
MODULATORY FACTOR OF IL-6 FUNCTION,
IN ORGANOTYPIC CULTURES OF MOUSE
CEREBELLUM. D. Arias-Salvatierra1, L. C.
Acosta-Saavedra1, P. C. Conde-Moo1, E. K.
Silbergeld2 and E. S. Calderon-Aranda1. 1Toxicology,
Cinvestav, Mexico, DF, Mexico and 2Bloomberg
School of Public Health, Johns Hopkins University,
Baltimore, MD.
#1777
MULTIPLE SOURCES MAY CONTRIBUTE
TO METHYLMERCURY-INDUCED
INCREASES IN [CA2+]I IN RAT CEREBELLAR
SLICES. Y. Yuan and W. D. Atchison. Pharml/
Toxicology, Mich State University East Lansing, MI.
#1778
EFFECTS OF ACTIVATION AND
INHIBITION OF GROUP I METABOTROPIC
GLUTAMATE RECEPTOR 1 SUBTYPE IN
METHYLMERCURY-INDUCED CALCIUM
DYSREGULATION OF RAT CEREBELLAR
GRANULE CELLS. A. Segarra-Arroyo2, 1, D.
K. Atchison1 and W. D. Atchison1. 1Department
Pharmacology/Toxicology, Mich State University
East Lansing, MI and 2Research Initiative for
Student Enhancement, University of Puerto Rico at
Cayey, Cayey, Puerto Rico.
#1779
EFFECTS OF METHYLMERCURY (MEHG)
ON GABAA RECEPTOR-MEDIATED
CURRENTS IN HEK-293 CELLS ARE NOT
ALTERED BY THE PRESENCE OF THE α6
SUBUNIT. C. J. Herden1, R. K. Hajela2, 1, Y. Yuan2
and W. D. Atchison2, 1. 1Neurosci. Progrm, Michigan
State University, East Lansing, MI and 2Department
of Pharmacology/Toxicology, Michigan State
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: NEUROTOXICITY: METALS—GENERAL
Chairperson(s): Stephen Lasley, Universtiy of Illinois, Peoria, IL and
Ginger Moser, U.S. EPA, Research Triangle Park, NC.
#1768
GENDER DIFFERENCES IN
AUTOANTIBODIES TO NERVOUS
SYSTEM PROTEINS RESULTING FROM
OCCUPATIONAL EXPOSURES TO LEAD OR
MERCURY. N. M. El-Fawal1, A. M. Musa2, M.
Y. Shamy2 and H. N. El-Fawal1. 1Neurotoxicology
Laboratory, Mercy College, Dobbs Ferry, NY and
2
Institute of Public Health, University of Alexandria,
Alexandria, Egypt. Sponsor: J. O’Callaghan.
#1769
DIMETHYLARSENIC IS THE MOST
ABUNDANT ARSENITE METABOLITE IN
MOUSE BRAIN. J. H. Limon1, M. E. Gonsebatt1,
V. M. Rodriguez5, E. Uribe-Querol3, G. GutierrezOspina3, M. Giordano4, L. C. Sanchez-Pena2 and
L. M. Del Razo2. 1Med. Genomica y Toxicology
Ambiental, Inst. de Invest Biomedicas, UNAM,
Mexico, DF, Mexico, 2Seccion de Toxicologia,
CINVESTAV, Mexico, DF, Mexico, 3Biologia
Celular y Fisiologia, Inst. de Invest Biomedicas,
UNAM, Mexico, DF, Mexico, 4Inst. de
Neurobiologia, UNAM, Queretaro, Qro, Mexico
and 5Environmental and Comunity Medicine, The
University of Medicine and Dentistry of New Jersey
and Rutgers, Piscataway, NJ.
#1770
#1771
MERCURY AND SELENIUM IN BRAIN
AND BLOOD AFTER CHRONIC, LOWLEVEL METHYLMERCURY EXPOSURE.
M. C. Newland and M. Reed. Psychology, Auburn
University, Auburn, AL.
LEAD ALTERS THE ABILITY OF THE
CHOROID PLEXUS (CP) TO SEQUESTER
BETA-AMYLOID FROM CEREBROSPINAL
FLUID (CSF). J. S. Crossgrove and W. Zheng.
School of Health Sciences, Purdue University, West
Lafayette, IN.
201
WEDNESDAY
45th Annual
Meeting & ToxExpo
#1780
DIFFERENTIAL VULNERABILITY OF
CORTICAL AND CEREBELLAR NEURONS
TOWARDS METHYLMERCURY INDUCED
NEUROTOXICITY. P. Kaur1, M. Aschner2 and T.
Syversen1. 1Department of Neuroscience, Norwegian
Norway and 2Department of Pediatrics, Vanderbilt
University Medical Center, Nashville, TN.
#1781
ALZHEIMER BETA-AMYLOID PEPTIDES
MODERATE METHYLMERCURY TOXICITY
IN YOUNG DROSOPHILA. K. R. Reuhl2, 3,
T. Gangi1, A. Halladay2, B. Buckley3 and M.
Konsolaki1. 1Department of Genetics, Rutgers
University, Piscataway, NJ, 2Pharmacology &
Toxicology, Rutgers University, Piscataway, NJ and
3
EOHSI, Rutgers University, Piscataway, NJ.
#1782
#1783
#1784
#1785
#1786
MERCURY COMPOUNDS AFFECT
INTRACELLULAR MOLECULAR SYSTEMS
AND CELLULAR MORPHOLOGY OF SHSY5Y CELLS. K. A. Thuett, M. E. Miller, E.
Tiffany-Castiglioni and L. C. Abbott. Veterinary
Integrative Biosciences, Texas A&M University,
College of Veterinary Medicine, College Station,
TX.
ORGANOMERCURIC COMPOUNDS
SELECTIVELY ALTER NEUROGENESIS IN
THE NEONATAL RAT HIPPOCAMPUS. A.
Falluel-Morel1, X. Zhou1, E. Smith1, A. Litterman1,
K. R. Reuhl2 and E. DiCicco-Bloom1. 1Neuroscience
& Cell Biology, UMDNJ, Piscataway, NJ and
2
Pharmacology & Toxicology, Rutgers University,
Piscataway, NJ.
A ROLE FOR P53 IN MOUSE MIDBRAIN
NEURAL PRECURSOR CELL (NPC) CELL
CYCLE ARREST AND PREMATURE
NEURONAL DIFFERENTIATION
FOLLOWING METHYLMERCURY
EXPOSURE. E. J. Gribble, X. Yu, S. Hong and
E. M. Faustman. Department of Environmental
THE EFFECT OF ETHYL MERCURY ON
WILDTYPE AND METALLOTHIONEIN-2
KNOCKOUT CAENORHABDITIS ELEGANS.
K. J. Helmcke1, 2, L. Evje3, T. Syversen3, R. Nass1
and M. Aschner4, 1, 2. 1Department of Pharmacology,
TN, 2Center in Molecular Toxicology, Vanderbilt
University Medical Center, Nashville, TN,
3
Department of Neuromedicine, Norwegian
Norway and 4Department of Pediatrics, Vanderbilt
University Medical Center, Nashville, TN.
WEDNESDAY
NEUROTOXICITY STUDIES OF DEPLETED
URANIUM. G. C. Jiang1, 2, K. Loveless2, B.
McLaughlin2, R. Nass3 and M. Aschner4, 2.
1
Physiology and Pharmacology, Wake Forest
University, Winston-Salem, NC, 2Pharmacology,
Vanderbilt University, Nashville, TN,
3
Anesthesiology, Vanderbilt University, Nashville,
TN and 4Pediatrics, Vanderbilt University, Nashville,
TN.
202
#1787
NEUROTOXIC EFFECTS OF LEAD ON
HUMAN NEUROBLASTOMA CELLS IN
CULTURE. C. S. Chetty1, M. C. Vemuri2, K.
Campbell1 and C. Suresh3. 1Natural Sciences and
Mathematics, Savannah State University, Savannah,
GA, 2Department of Surgery, Childrens’ Hospital of
Philadelphia, Philadelphia, PA and 3Biochemistry,
National Institute of India, Hyderabad, Andhra
Pradesh, India.
#1788
MODULATION OF CA2+-INDEPENDENT,
PB2+-INDUCED EXOCYTOSIS FROM
RAT PC12 CELLS BY CAM KINASE II. R.
Westerink and H. Vijverberg. Cellular and Molecular
Toxicology, Institute for Risk Assessment Sciences
- Utrecht University, Utrecht, Netherlands. Sponsor:
M. van den Berg.
#1789
CHRONIC LEAD REDUCES ELECTRICALLY
STIMULATED HIPPOCAMPAL BRAINDERIVED NEUROTROPHIC FACTOR
(BDNF) RELEASE. S. M. Lasley and L. C. Wang.
Biomedical & Therapeutic Sciences, University of
Illinois College of Medicine, Peoria, IL.
#1790
GESTATIONAL LEAD EXPOSURE
SWITCHES CELL FATE AND INCREASES
PROLIFERATION OF RETINAL
PROGENITOR CELLS IN DEVELOPING
MOUSE RETINA. A. Giddabasappa, J. E.
Johnson, W. Xiao, S. Chaney, Q. Chen and D. A. Fox.
University.Houston, Houston, TX.
#1791
BCL-XL OVEREXPRESSION PROTECTS
ROD PHOTORECEPTOR SYNAPTIC
TERMINAL MITOCHONDRIA FROM LEADINDUCED PERMEABILITY TRANSITION.
G. A. Perkins2, J. Brown2, P. Lahsaei2, S.
Ghassemzadeh2, M. H. Ellisman2, J. E. Johnson1 and
D. A. Fox1. 1University of Houston, Houston, TX and
2
University of California, San Diego, CA.
#1792
EVALUATION OF ZINC TOXICITY USING
NEURONAL NETWORKS CULTURED ON
MICROELECTRODE ARRAYS. M. Parviz1,
C. J. Fredrickson2 and G. W. Gross1. 1Biological
Sciences, University of North Texas, Denton, TX
and 2Departments of Anatomy and Neuroscience,
The University of Texas Medical School, Galveston,
TX. Sponsor: T. Shafer.
#1793
MODERATE PERINATAL ARSENIC
EXPOSURE ELEVATES MARKERS OF
SEROTONERGIC NEUROTRANSMISSION IN
DORSAL HIPPOCAMPAL FORMATION OF
ADULT MICE. E. J. Martinez, D. D. Savage and
A. M. Allan. University of New Mexico School of
Medicine, Albuquerque, NM.
#1794
NEUROTOXICITY OF ALUMIUM IN MOUSE
BRAIN. M. Hwang, S. Kim, Y. Yum, J. Ko, S.
Kim, J. Kim, C. Song, J. Kim and D. Jang. General
Toxicology, National Instititue of Toxicological
Research, Seoul, South Korea. Sponsor: J. Chung.
45th Annual
Meeting & ToxExpo
#1796
STRIATAL CFOS EXPRESSION DURING
POSTNATAL DEVELOPMENT IN THE
RAT: EFFECTS OF INORGANIC LEAD
(PB) EXPOSURE AND AMPHETAMINE
CHALLENGE. Q. Cai and D. K. Pitts.
Detroit, MI.
Wednesday, March 8
9:00 AM to 12:00 NOON
Exhibit Hall
POSTER SESSION: P450 EXPRESSION AND REGULATION
Chairperson(s): Roger Couloumbe, Utah State University, Logan, UT and
Juan Hernandez, University Texas at El Paso, El Paso, TX.
C-FOS EXPRESSION IS DIFFERENTIALLY
ACTIVATED BY METHYLMERCURIC
CHLORIDE AND PSYCHOGENIC
STRESSORS IN THE MURINE BRAIN. J. F.
Cooper. Toxicology, Rutgers University/ UMDNJ,
Piscataway, NJ.
#1797
PROTEOMIC ANALYSIS OF PB2+ EXPOSURE
ON PROTEINS IN THE AUDITORY
BRAINSTEM. J. Prins and D. I. Lurie. Biomedical
and Pharmaceutical Sciences and Center for
Environmental Health Sciences, University of
Montana, Missoula, MT. Sponsor: A. Holian.
#1798
EFFECT OF SUBCHRONIC ARSENITE
EXPOSURE ON SENSORY SURAL NERVES
OF RATS. E. Garcia-Chavez1, B. Segura2, H.
Merchant3, L. C. Sanchez-Pena1, I. Jimenez4 and
L. M. Del Razo1. 1Toxicology, Cinvestav, Mexico
D.F., Mexico, 2FES-Iztacala, UNAM, Mexico D.F.,
Mexico, 3IIB-UNAM, Mexico D.F., Mexico and
4
Physiology & Biophysics, Cinvestav, Mexico D.F.,
Mexico.
#1799
NEUROTOXICITY EVALUATION OF
DIBUTYLTIN IN ADULT RATS. V. C. Moser, P.
M. Phillips and K. L. McDaniel. NTD/NHEERL,
#1800
STRESS AND DEPLETED URANIUM
EXPOSURE ALTER HIPPOCAMPAL
DENDRITIC MORPHOLOGY IN THE RAT. R.
F. Mervis1, 4, D. S. Barber2, M. Ehrich3, S. Hancock3,
J. Hinckley3, J. Kotick1, 5, M. Shah1, T. Amato5 and B.
S. Jortner3. 1Neurostructural Research Laboratories,
Tampa, FL, 2Center for Environmental and Human
Toxicology, University of Florida, Gainesville, FL,
3
Laboratory for Neurotoxicity Studies, Virginia
Tech, Blacksburg, VA, 4Center for Aging & Brain
Repair, University of South Florida, Tampa, FL and
5
The Honors College, University of South Florida,
Tampa, FL.
#1801
#1802
NEUROLOGICAL EFFECTS OF CHRONIC
URANIUM AND STRESS EXPOSURE. D.
S. Barber1, S. K. Hancock2, J. Hinckley2, K.
Zimmerman3, M. F. Ehrich2 and B. S. Jortner2.
1
Center for Environmental and Human Toxicology,
University of Florida, Gainesville, FL, 2Laboratory
for Neurotoxicity Studies, Virginia Tech,
Blacksburg, VA and 3Biomedical Science, Virginia
Tech, Blacksburg, VA.
LONG-TERM BEHAVIORAL
CONSEQUENCES OF MATERNAL LEAD
(PB) AND STRESS: PREFERENTIAL
VULNERABILITY OF FEMALES. M. Virgolini,
D. D. Weston, R. Lisek, M. Thiruchelvam and D.
A. Cory-Slechta. Environmental and Occupational
Health Sciences Institute, Robert Wood Johnson
Medical School, UMDNJ, Piscataway, NJ.
203
#1803
INDUCTIVE EFFECT OF PYRIDAZINE
(PZ) ON CYTOCHROME P4502E1
(CYP2E1) ALTERS THE METABOLISM OF
TRICHLOROETHYLENE (TCE). S. Lee, C.
A. White, S. Muralidhara, S. S. Anand and J. V.
Bruckner. Department of Pharmaceutical and
Biomedical Sciences/Interdisciplinary Program in
Toxicology, University of Georgia, Athens, GA.
#1804
TERTIARY AMYL METHYL ETHER
(TAME) INCREASES HEPATIC TOXICITY
PARAMETERS AND ALTERS XENOBIOTIC
METABOLIZING ACTIVITY IN HEPATIC
AND RESPIRATORY TISSUES FOLLOWING
AN ACUTE ORAL EXPOSURE. J. L. Weissert
and R. A. Schatz. Toxicology, Northeastern
University, Boston, MA.
#1805
MECHANISM OF INACTIVATION IN HUMAN
CYP2A6 GENETIC VARIANTS CYP2A6*2
AND CYP2A6*5. K. George1, X. He1, W. Hu1 and
J. Hong1, 2. 1Joint program in Toxicology, Rutgers
University and UMDNJ, Piscataway, NJ and 2School
of Public health/Environmental and Occupational
Health Sciences Institute, University of Medicine
and Dentistry of New Jersey, Piscataway, NJ.
#1806
EFFECT OF AGE AND GENDER ON IN
VITRO S-MEPHENYTOIN HYDROXYLASE
ACTIVITY AND CYTOCHROME 2C19
PROTEIN EXPRESSION. S. M. Bandiera,
A. Mirfazaelian and J. Sebelova. Faculty of
Pharmaceutical Sciences, University of British
Columbia, Vancouver, BC, Canada.
#1807
CYP1A1-GFP TRANSGENIC MOUSE
MODEL: FLUORESCENT BIOMARKER
OF TOXICANT EXPOSURE. T. N. Operana1,
2
, N. Nguyen1, 2, S. Chen1, 2, D. Beaton1, 2 and R. H.
Tukey1, 2. 1Pharmacology, University of California,
San Diego, La Jolla, CA and 2Chemistry &
Biochemistry, University of California, San Diego,
La Jolla, CA.
#1808
EVALUATION OF A RAPID ASSESSMENT
FOR MEASURING ENZYMATIC P450
ACTIVITY IN THE IMMORTALIZED HUMAN
HEPATOCYTE CELL LINE FA2N-4. R. de
Guzman2, L. D. Marroquin1, A. de Peyster2, G.
Stevens1 and Y. Will1. 1Safety Sciences, Pfizer, San
Diego, CA and 2Graduate School of Public Health,
San Diego State University, San Diego, CA.
WEDNESDAY
#1795
45th Annual
Meeting & ToxExpo
#1809
CHARACTERIZATION OF KNOCK-IN MICE
EXPRESSING SUBCELLULAR ORGANELLESPECIFIC CYP1A1 PROTEIN. H. Dong, T. P.
Dalton and D. W. Nebert. University of Cincinnati
#1810
CYP1A1 IN LIVER AND INTESTINE
PROTECTS, WHILE CYP1B1 IN IMMUNE
CELLS POTENTIATES, IN ORAL
BENZO[a]PYRENE-INDUCED DISEASE.
N. Dragin1, S. Uno2, T. P. Dalton1, S. Derkenne1,
C. P. Curran1, M. L. Miller1, H. G. Shertzer1, F.
J. Gonzalez3 and D. W. Nebert1. 1University of
Cincinnati Medical Center, Cincinnati, OH, 2Nihon
University, Tokyo, Japan and 3National Cancer
Institute, Bethesda, MD.
#1811
#1812
#1813
#1814
#1815
MICE LACKING THE GENE FOR
CYTOCHROME P450 (CYP)1A1
OR 1A2 DISPLAY DIFFERENTIAL
SUSCEPTIBILITIES TO HYPEROXIC LUNG
INJURY. B. Moorthy, L. Wang, K. Muthiah, X. I.
Couroucli, S. Kondraganti and W. Jiang. Pediatrics,
Baylor College of Medicine, Houston, TX.
ATTENUATION OF OXYGEN-INDUCED
ABNORMAL LUNG MATURATION IN RATS
BY RETINOIC ACID: POSSIBLE ROLE
OF CYTOCHROME P4501A ENZYMES. X.
Couroucli1, Y. Wei1, W. Jiang1, R. Barrios2 and B.
Moorthy1. 1Pediatrics, Baylor College of Medicine,
Houston, TX and 2Pathology, The Methodist
Hospital, Houston, TX.
EFFECTS OF 3’, 4’, 3, 5, 7-O-METHYLATED
EPICATECHIN ON THE ARYL
HYDROCARBON RECEPTOR AND CYP 1A1
IN MCF-7 HUMAN BREAST CARCINOMA
CELLS. E. Han1, 2, J. Kim1, 2, K. Oh1, 2, Y. Hwang1,
2
, T. Jeong3, E. Lee3 and H. Jeong1, 2. 1Pharmacy,
Chosun University, Kwangju, South Korea, 2College
of Pharmacy, Research Center for Proteineous
Korea and 3College of Pharmacy, Yeungnam
University, Kyungsan, South Korea.
COMPARATIVE ANALYSIS OF GENE
EXPRESSION BY POLYCYCLIC AROMATIC
HYDROCARBONS IN THREE HUMAN
CELL LINES: HEPG2, JURKAT AND A549
CELLS. F. Castorena-Torres1, M. Bermudez de
Leon2, O. Zapata-Perez3, B. Cisneros2, J. E. Salinas4
and A. Albores1. 1TOXICOLOGY, CINVESTAVIPN, Mexico City, D.F., Mexico, 2GENETICS,
CINVESTAV-IPN, Mexico City, D.F., Mexico,
3
MARINE SCIENCES, CINVESTAV-IPN, Merida,
Yucatan, Mexico and 4SECRETARIA DE SALUD,
CINVESTAV-IPN, Sabinas, Coahuila, Mexico.
WEDNESDAY
DOWN-REGULATION OF CYP3A4 IN
HUMAN PRIMARY HEPATOCYTES AND
HUMAN LS180 COLORECTAL CARCINOMA
CELLS BY SULFORAPHANE. K. GrossSteinmeyer1, C. Zhu2, P. L. Stapelton1, J. H. Tracy1,
T. Bammler1, S. C. Strom3, K. E. Thummel2 and D.
L. Eaton1. 1Env. Occup. Health Sciences, University
Washington, Seattle, WA, 2Pharmaceutics,
University Washington, Seattle, WA and 3Pathology,
University Pittsburgh, Pittsburgh, PA.
204
#1816
INDUCTION OF CYTOCHROME P450 1A ON
EXPOSURE TO DIBENZO[A, L]PYRENE IN
ZEBRAFISH (Danio rerio). G. E. Corley-Smith1,
2
, B. Mahadevan1, E. Brooks1, J. Wang-Buhler1, W.
M. Baird1, 4 and D. R. Buhler1, 3, 4. 1Environmental
Corvallis, OR, 2Center for Genome Research and
Biocomputing, Oregon State University, Corvallis,
OR, 3Marine and Freshwater Biomedical Science
4
Environmental Health Sciences Center, Oregon
State University, Corvallis, OR.
#1817
EFFECTS OF SIX POLYCYCLIC AROMATIC
HYDROCARBONS ON ACTIVITIES OF
HEPATIC AND PULMONARY CYTOCHROME
P450S IN MALE SPRAGUE-DAWLEY RATS.
C. Jin1, T. Jeon1, S. Lee1, G. Kim1, I. Jun1, D. Lee1,
H. Jeong2 and T. Jeong1. 1College of Pharmacy,
Yeungnam University, Gyeongsan, South Korea and
2
College of Pharmacy, Chosun University, Gwangju,
South Korea.
#1818
DISRUPTION OF CYP1A2 GENE
MODULATES 3-METHYLCHOLANTHRENEMEDIATED REGULATION OF HEPATIC
AND PULMONARY CYP1A1 EXPRESSION IN
MICE. W. Jiang, S. R. Kondraganti, K. Muthiah, L.
Wang and B. Moorthy. Pediatrics, Baylor College of
Medicine, Houston, TX.
#1819
A CYP3A4 INDUCTION DATABASE
CORRELATING IN VITRO INDUCTION
ASSAYS WITH CLINICAL INDUCTION. C.
Healan-Greenberg, E. L. Feucht, B. P. Murray, E.
A. Blomme and J. F. Waring. Abbott Laboratories,
Abbott Park, IL.
#1820
INDUCTION OF CYTOCHROMES P450 1A1,
2B AND 3A IN RAT LIVER BY BITERTANOL.
T. Ueng, P. Chan, Y. Tsai and C. Wei. Institute of
Toxicology, National Taiwan University, Taipei,
Taiwan.
#1821
EFFECT OF FIPRONIL ON THE HEPATIC
MICROSOMAL CYTOCHROME P450
ENZYMES. M. R. Martinez-Larranaga1, V.
Caballero1, M. J. Diaz1, M. A. Martinez1, M.
Martinez1, J. del Pino1 and A. Anadon1. 1Department
of Toxicology and Pharmacology, Complutense
University, Madrid, Spain and 2Department of
Toxicology and Pharmacology, Complutense
University, Madrid, Spain.
#1822
EFFECT OF DDT ON EXPRESSION
OF HEPATIC CYTOCHROME P450 IN
OVARIECTOMIZED RATS. A. Garcia-Jimenez,
L. M. Lopez-Gonzalez, A. Sierra-Santoyo and M.
E. Cebrián. Toxicology, CINVESTAV-IPN, Mexico
City, D.F., Mexico.
#1823
THE EFFECT OF DIISOPROPYL ETHER
(DIPE) ON CYTOCHROME P450 ISOZYMES
IN RESPIRATORY AND HEPATIC
TISSUES AFTER ACUTE AND SUB-ACUTE
INHALATION EXPOSURE. E. M. Stagliola and
R. A. Schatz. Toxicology, Northeastern University,
Boston, MA.
45th Annual
Meeting & ToxExpo
BUTHIONINE SULFOXIMINE (BSO)
MODULATES CYP1A ACTIVITY. M. E.
Gonsebatt, G. Zamora and J. Espinosa Aguirre.
Medicina Genomica y Toxicologia Ambiental,
Instituto de Investigaciones Biomedicas, UNAM,
Mexico, DF, Mexico.
#1825
EFFECTS OF DIELDRIN AND
PHENOBARBITAL ON THE LEVELS OF
MESSENGER RNA OF TOXICOLOGICALLY
IMPORTANT GENES. M. Dail1, 2, S. Burgess2,
1
, M. K. Ross1, 2 and J. Chambers1, 2. 1Center for
Environmental Health, Mississippi State, Mississippi
State, MS and 2Basic Science, Mississippi State,
#1826
#1827
COMPARATIVE STUDY OF THE EFFECTS
OF SPIRONOLACTONE, PREGNENOLONE
16 ALPHA-CARBONITRILE AND
DEXAMETHASONE ON MOUSE HEPATIC
DRUG METABOLIZING AND OTHER
CHEMOPROTECTIVE ENZYMES. M. R.
Franklin and W. M. El Sayed. Pharmacology and
Toxicology, University of Utah, Salt Lake City, UT.
ACTIVATION OF PREGNANE X RECEPTOR
(PXR) AND CONSTITUTIVE ANDROSTANE
RECEPTOR (CAR) BY OCTAMETHYLCYCL
OTETRASILOXANE (D4) AND DECAMETHY
LCYCLOPENTASILOXANE (D5) IN VITRO. P.
A. Jean1, J. A. Arthurton1, L. You2 and K. P. Plotzke1.
1
Dow Corning Corporation, Midland, MI and 2CIIT,
#1828
ST. JOHN’S WORT REDUCES
TRIBROMOETHANOL-INDUCED SLEEP
TIMES IN SXR TRANSGENIC MICE. S. E.
Lacher, L. M. Oko, A. C. Protain, H. J. Protain, C.
S. Gardiner and G. DeKrey. School of Biological
Sciences, University of Northern Colorado, Greeley,
CO.
#1829
INDUCTION OF HEPATIC ENZYME
EXPRESSION BY P-NONYLPHENOL (NP)IS
MODULATED BY DIET IN MALE SPRAGUEDAWLEY RATS. X. Fu, S. M. Cooper and K. B.
Delclos. National Center for Toxicological Research,
Jefferson, AR.
#1830
#1831
NONYLPHENOL INDUCES P450S IN A
GENDER-SPECIFIC MANNER. J. P. Hernandez,
L. M. Chapman, X. C. Kretschmer and W. S.
Baldwin. Biological Sciences, University of Texas at
El Paso, El Paso, TX.
14-WEEK ORAL TOXICITY
STUDIES OF KAVA IN F344 RATS:
IMMUNOHISTOCHEMICAL ANALYSIS OF
EXPRESSIONS OF HEPATIC CYTOCHROME
P450. N. P. Clayton1, K. Yoshizawa2, G. Kissling1,
P. Chan1, L. T. Burka1 and A. Nyska1. 1NIEHS,
Research Triangle Park, NC and 2Astellas Pharma,
Osaka, Japan.
#1832
CLONING, EXPRESSION AND PARTIAL
CHARACTERIZATION OF A NOVEL
CYTOCHROME P450 FROM TURKEY LIVER
THAT CATALYZES EPOXIDATION OF
AFLATOXIN B1. R. A. Coulombe and S. S. Yip.
Graduate Toxicology Program and Department of
Veterinary Sciences, Utah State University, Logan,
UT.
#1833
GENERATION AND CHARACTERIZATION
OF A CYP2A13 TRANSGENIC MOUSE
MODEL. Y. Wei1, 2, X. Zhou1, 2, G. Ling1, X.
Zhang1, J. D’Agostino1, 2, J. Gu1, K. Kluetzman1, 2
and X. Ding1, 2. 1Wadsworth Center, New York State
Department of Health, Albany, NY and 2School
of Public Health, State University of New York at
Albany, Albany, NY.
#1834
ZEBRAFISH CYTOCHROME P450 3C1:
CLONING, DEVELOPMENTAL EXPRESSION,
PHYLOGENETIC AND IN SILICO GENE
ANALYSIS. J. Wang-Buhler1, H. Tseng4, C. Hu4,
H. Su4, G. E. Corley-Smith1 and D. R. Buhler1, 2, 3.
1
Environment & Molec. Toxicology, Oregon State
University, Corvallis, OR, 2Marine and Freshwater
Biomedical Sciences Center, Oregon State
University, Corvallis, OR, 3Environmental Health
Sciences Center, Oregon State University, Corvallis,
OR and 4Institute of Bioscience and Biotechnology,
National Taiwan Ocean University, Keelung, Taiwan.
#1835
FUNCTIONAL CHARACTERIZATION OF
HUMAN AND MOUSE CYTOCHROME
P450 2S1 PROTEINS USING A BACTERIAL
RECOMBINANT EXPRESSION SYSTEM. P.
H. Bui1, 2 and O. Hankinson1, 2, 3. 1UCLA Molecular
Toxicology I.D.P., University of California-Los
Angeles, Los Angeles, CA, 2Pathology and
Laboratoty Medicine, University of CaliforniaLos Angeles, Los Angeles, CA and 3Molecular
Biology Institute, and Johsson Comprehensive
Cancer Center, David Geffen School of Medicine,
University of California-Los Angeles, Los Angeles,
CA.
Wednesday, March 8
9:45 AM to 10:45 AM
Room 11A
INFORMATIONAL SESSION: CREATE BIBLIOGRAPHIES
INSTANTLY WITH ENDNOTE AND DISCOVER NEW
REFERENCE TOOLS
Presented by Thomson ResearchSoft
EndNote is used by millions of scientists worldwide to organize reference literature and create bibliographies instantly. Learn about EndNote
9 and three new software products that simplify research and publishing:
Onfolio™—organize Web pages and synchronize reference data with
EndNote, RefViz™—explore references visually, and sciPROOF™—
streamline scientific proofreading.
205
WEDNESDAY
#1824
45th Annual
Meeting & ToxExpo
Wednesday, March 8
9:45 AM to 10:45 AM
Room 11B
Wednesday, March 8
12:00 NOON to 1:30 PM
Room 6D
INFORMATIONAL SESSION: EXPANDING ROLE OF
TELEMETRY IN TOXICOLOGY
SPECIAL SESSION: MEET THE DIRECTORS SESSION: AN
UPDATE OF ACTIVITIES AT GOVERNMENT AGENCIES
Presented by Data Sciences International
Speakers: David A. Schwartz, National Institute of Environmental
Health Sciences, Research Triangle Park, NC; George Gray, U.S. EPA,
Washington, DC; and Anna D. Barker, National Cancer Institute, Bethesda,
MD.
Advances in implantable technology and computerized data collection and
analysis have enabled new applications in physiology, pharmacology, safety
assessment and toxicology. This session will review the traditional application of telemetry to research as well as cover recent application and product
developments facilitating applications in Toxicology.
Wednesday, March 8
11:00 AM to 12:00 NOON
Room 11A
INFORMATIONAL SESSION: INTEGRATION OF IN-LIFE
PARAMETERS WITH TOXICOGENOMICS
In this session, leaders of several major federal agencies will engage in a
panel discussion of emerging trends in toxicology research and its funding.
Attendees will gain a better understanding of the toxicology research activities sponsored by the agencies, will hear about changes of direction and
new initiatives concerning toxicology. Speakers will identify opportunities
where non-agency toxicologists may be able to participate in initiatives of
their agencies and will answer questions of attendees.
Wednesday, March 8
12:15 PM to 1:15 PM
Room 11A
A case study example of mechanistic analysis using cardiac gene expression data integrated with classical in-life parameters indicative of cardiac
toxicity. Examples will be given of how the analysis can include crosscompound comparisons, and identify prognostic and diagnostic markers
of toxicity, i.e., those precedent and coincident with classical measures,
respectively.
Wednesday, March 8
11:00 AM to 12:00 NOON
Room 11B
INFORMATIONAL SESSION: ADVANCES IN INTEGRATED
MICROARRAY ANALYSIS
Presented by Agilent
An Agilent sponsored event on advances in gene expression profiling,
other emerging microarray applications including aCGH, ChiP-on-Chip,
splice variant analysis, as well as proteomic analysis. The talks will include
discussions on Agilent’s higher density microarrays, multi-array slide
formats and integration of data sets from multiple microarray applications.
Wednesday, March 8
1:30 PM to 2:30 PM
Room 11B
INFORMATIONAL SESSION: THE FUTURE OF
HEMATOPOIETIC TESTING
Presented by StemCell Technologies, Inc.
Bone marrow CFU assays are currently the standard for in vitro hematopoietic testing and utilized in late drug toxicity screening. We will discuss
miniaturization of the assay amenable for potential automation to allow
implementation in late discovery/early pre-clinical phase. Discussion will
follow addressing various assays designed for screening potential cytokines.
Wednesday Afternoon
INFORMATIONAL SESSION: NOVEL BD GENTEST™ ADME/
TOX TECHNOLOGIES FOR METABOLISM AND TOXICITY
Presented by BD Biosciences
BD Biosciences is the leader in ADME/Tox products and services
providing a large range of reagents, plastic consumables, instruments, and
contract research services. We have recently developed several novel technologies to study and predict in vitro toxicity parameters for drug discovery
and development. Products include BD Gentest™ Transporter Systems,
BD GentestSM Contract Research Services, BD Gentest™ Serum Binding
System, BD Gentest Hepatocytes, and toxicity biomarker test kits.
WEDNESDAY
Wednesday, March 8
12:00 NOON to 1:30 PM
Exhibit Hall
Wednesday, March 8
1:30 PM to 2:30 PM
Room 11A
INFORMATIONAL SESSION: USING HISTOLOGICAL
EVALUATION TO ENHANCE THE BOVINE CORNEA
OPACITY AND PERMEABILITY (BCOP) ASSAY FOR OCULAR
IRRITATION
Hall on-site.
Presented by Institute for In Vitro Sciences
The BCOP is widely used to assess ocular irritation. Although the standard
end points are generally predictive, damage caused through certain modes
of action is sometimes missed. Histological evaluation aids predictions by
allowing direct measure of depth and area of injury, and a characterization
of the specific lesions induced.
206
45th Annual
Meeting & ToxExpo
Wednesday, March 8
1:30 PM to 4:30 PM
Room 6E
Wednesday, March 8
1:30 PM to 4:30 PM
Room 6A
SYMPOSIUM SESSION: THE BASES FOR INTER-INDIVIDUAL
DIFFERENCES IN SUSCEPTIBILITY TO ALLERGIC DISEASE
SYMPOSIUM SESSION: DETERMINANTS OF MANGANESE
NEUROTOXICITY: FROM WORMS TO MAN
Chairperson(s): G. Frank Gerberick, Procter & Gamble Company,
Cincinnati, OH.
Chairperson(s): Tomas Guilarte, Johns Hopkins University, Baltimore, MD
and Michael Aschner, Vanderbilt University Medical Center, Nashville, TN.
Endorsed by:
Endorsed by:
Neurotoxicology SS*
Mechanisms SS
Metals SS
#1836
1:30
THE BASES FOR INTER-INDIVIDUAL
DIFFERENCES IN SUSCEPTIBILITY TO
ALLERGIC DISEASE. I. Kimber1 and F.
Gerberick2. 1Syngenta, Macclesfield, United
Kingdom and 2Procter & Gamble, Cincinatti, OH.
#1837
1:35
CHEMICAL AND PROTEIN ALLERGY:
IMMUNOLOGICAL MECHANISMS AND
CLINICAL CHARACTERISTICS. I. Kimber.
Syngenta, Macclesfield, United Kingdom.
#1838
2:10
HERITABLE AND ACQUIRED FACTORS
INFLUENCING SUSCEPTIBILITY TO
ALLERGIC CONTACT DERMATITIS. G.
Gerberick. Procter & Gamble, Cincinnati, OH.
#1839
2:45
HERITABLE AND ACQUIRED FACTORS
INFLUENCING SUSCEPTIBILITY TO
CHEMICAL RESPIRATORY ALLERGY. S. M.
Tarlo1, 2. 1Medicine, University of Toronto, Toronto,
ON, Canada and 2Medicine, Respiratory Division,
Toronto Western Hospital, Toronto, ON, Canada.
Sponsor: I. Kimber.
#1840
3:20
CHEMICAL POLLUTION, GENETIC
FACTORS AND THE CHANGING
PREVALENCE OF ATOPIC ALLERGY AND
ASTHMA. B. Nemery2 and I. Kimber1. 1Syngenta,
Macclesfield, United Kingdom and 2Laboratory
of Pneumology, K.Universtiy of. Leuven, Leuven,
Belgium.
#1841
3:55
FACTORS GOVERNING THE ACQUISITION
OF FOOD ALLERGY. R. J. Dearman and I.
Kimber. Syngenta, Macclesfield, United Kingdom.
Manganese is essential for normal physiological function in humans.
However, occupational or environmental exposures to excess levels of
manganese are associated with adverse effects on the central nervous
system. Human exposure to manganese varies depending on geographical
location, urban or rural environment, diet, and importantly, occupational
settings. Furthermore, acute or chronic exposure to different chemical
forms of manganese may occur at different life-stages. These factors along
with diverse genetic composition are likely to impart differential sensitivity
of individuals to manganese neurotoxicity. This symposium is meant to
identify the contribution of modifiers such as age, nutritional status and
genetics, to the vulnerability of individuals to manganese neurotoxicity.
Speakers will detail advantages offered by invertebrate animal models in
deciphering the mechanisms and genetics of manganese neurotoxicity. The
role of diet in particular iron deficiency will be discussed in relation to
manganese transport into cultured brain endothelial cells and regional brain
distribution. Behavioral, neuroimaging and pathological endpoints will be
described in a non-human primate model of chronic manganese exposure.
These studies are prospective in nature and follow in parallel the effects of
manganese exposure on cognitive and motor function and neurochemical
changes in the living brain. Finally, biomarkers for the human diagnosis of
early manganese exposure will be highlighted. The multidisciplinary nature
of the symposium, bringing together scientists with expertise in behavioral, molecular, brain imaging and human population studies, is aimed at
providing a comprehensive state-of-the-art account of recent advances in
the fast-paced research area on manganese neurotoxicity.
207
#1842
1:30
DETERMINANTS OF MANGANESE
NEUROTOXICITY: FROM WORMS TO MEN.
T. R. Guilarte1 and M. Aschner2. 1Envir Health
Sciences, Johns Hopkins Public Health, Baltimore,
MD and 2Pediatrics, Vanderbilt University,
Nashville, TN.
#1843
1:35
MANGANESE-INDUCED DOPAMINE
NEURODEGENERATION IN C. ELEGANS:
PHARMACOGENETIC ANALYSIS IN A
NOVEL MODEL OF MANGANISM. R. M.
Nass1, 2, M. Fullard1, 2, K. Fallen1, 2, J. Andresen1, 2,
C. McManus1, 2 and M. Marvanova1, 2. 1Department,
of Anesthesiology, Vanderbilt University Medical
Center, Nashville, TN and 2Pharmacology,
TN.
#1844
2:10
DIETARY IRON MODULATES MANGANESE
NEUROTOXICITY. M. Aschner1, V. Fitsanakis1
and K. Erikson2. 1Department of Pediatrics,
Vanderbilt University Medical Center, Nashville, TN
and 2Department of Nutrition, University of North
Carolina, Greensboro, NC.
WEDNESDAY
Allergy is a diverse family of diseases that continues to provide important
and substantial challenges for toxicology and occupational and environmental medicine. Skin sensitization, resulting in allergic contact dermatitis,
represents the most common manifestation of immunotoxicity in humans,
and the prevalence of atopic allergy has increased significantly in the
USA and Europe. In recent years there have been impressive advances
made in the identification and characterization of chemicals and proteins
that have the potential to cause allergic sensitization, and in the development of improved approaches to risk assessment. However, there remains
considerable uncertainty about the factors that determine well-documented
inter-individual differences in susceptibility to chemical and protein allergy.
The purpose of this Symposium is to review new and emerging information on the cellular and molecular mechanisms responsible for heritable
and acquired differences in susceptibility to allergic diseases.
45th Annual
Meeting & ToxExpo
#1845
#1846
#1847
2:45
3:20
3:55
COGNITIVE AND MOTOR EFFECTS OF
CHRONIC MANGANESE EXPOSURE IN
NON-HUMAN PRIMATES. J. Schneider1, E.
Decamp1, S. Fritz1, A. Schultz1, H. Emberger1
and T. R. Guilarte2. 1Pathol., Anatomy and Cell
Biol., Thomas Jefferson University, Phila., PA and
2
Environment Health Sciences., Johns Hopkins
inhaled PSP. This data, in turn, significantly impacts the setting of international exposure standards for PSP.
NEUROIMAGING AND
NEUROPATHOLOGICAL CHANGES IN
THE NON-HUMAN PRIMATE BRAIN
FOLLOWING MANGANESE EXPOSURE.
T. R. Guilarte1, M. Chen1, J. L. McGlothan1, D. F.
Wong2, Y. Zhou2, M. Alexander2, P. Barker2, M.
Degaonkar2, C. A. Rohde3, T. Syversen4 and J. S.
Schneider5. 1Env Health Sciences, Johns Hopkins
Public Health, Baltimore, MD, 2Radiology, Johns
Hopkins Medicine, Baltimore, MD, 3Biostatistics,
Johns Hopkins Public Health, Baltimore, MD,
4
Neuroscience, Norwegian University Sciences Tech,
Trondheim, Norway and 5Pathol Anat & Cell Biol,
Thomas Jefferson University Philadelphia, PA.
DISCOVERY OF BIOMARKERS OF
MANGANESE EXPOSURE IN HUMANS. W.
Zheng. Purdue University, West Lafayette, IN.
#1848
1:30
MECHANISMS OF LOW SOLUBILITY
PARTICLE-INDUCED LUNG TUMORS. A.
Elder. Environmental Medicine, University of
#1849
1:50
MECHANISMS OF PSP TOXICITY:
PARTICLE SURFACE AREA AND SIZE. G.
Oberdorster. Environmental Medicine, University of
#1850
2:20
A MECHANISTIC EVALUATION OF SPECIES
DIFFERENCES IN PARTICLE-INDUCED
PULMONARY INFLAMMATION. K. Driscoll
and J. Carter. Procter & Gamble, Mason, OH.
#1851
2:50
A SPECIES COMPARISON OF THE
MECHANISMS UNDERLYING THE
PULMONARY OXIDANT/ANTIOXIDANT
RESPONSE AFTER INHALATION OF
POORLY-SOLUBLE PARTICLES (PSP). J.
Carter. Central Product Safety, Procter & Gamble
Co., Cincinnati, OH.
#1852
3:20
NASAL TOXICITY OF INHALED POORLY
SOLUBLE PARTICLES: EPITHELIAL AND
INFLAMMATORY RESPONSES TO INHALED
ULTRAFINE CARBON BLACK PARTICLES
IN RODENT NASAL AIRWAYS. J. R. Harkema1,
P. Santhanam1, J. Wagner1, A. Elder2, J. Carter3
and G. Oberdorster2. 1Pathobiology, Michigan
State University, East Lansing, MI, 2Environmental
Medicine, University of Rochester, Rochester, NY
and 3Procter & Gamble Co., Cincinnati, OH.
#1853
3:50
INHALATION OF POORLY SOLUBLE
PARTICLES AND LUNG CANCER:
PARADIGMS AND RISK ASSESSMENT. P.
Borm1 and J. Carter2. 1Centre of Expertise in Life
Sciences, Heerlen, Netherlands and 2Procter &
Gamble, Cincinnati, OH.
Wednesday, March 8
1:30 PM to 4:30 PM
Room 1B
SYMPOSIUM SESSION: MECHANISMS OF LOW SOLUBILITY
PARTICLE-INDUCED LUNG TUMORS
Chairperson(s): Janet Carter, Procter & Gamble Company, Cincinnati,
OH and Alison Elder, University of Rochester, Rochester, NY.
Endorsed by:
WEDNESDAY
Although our understanding of the processes underlying the pathogenesis
of particle-induced lung disease has greatly improved over the years, questions still remain regarding the issues of species differences in response
to inhaled particles, the mechanisms underlying these differences, and
their impact on human hazard evaluation and risk assessment processes.
Poorly-soluble particles (PSP) have several common characteristics:
they are low in solubility, have low toxicity, and are non-mutagenic and
non-genotoxic. Numerous inhalation studies in rodent species have been
conducted to assess the dose-related toxicity of these PSP (e.g. carbon
black, titanium dioxide, talc, and coal and shale dusts). Studies conducted
in rats have demonstrated that chronic inhalation of high doses of these
materials results in increased pulmonary inflammation, fibrosis, epithelial
hyperplasia, and, in some cases, adenomas and carcinomas in the peripheral rat lung. This response is generally referred to as an overload response
or threshold effect. The hypothesis that a threshold effect is relevant to
the tumor response in rats is supported by data from numerous studies
indicating that at exposure levels below that which causes a persistent
inflammatory response, tumors are not produced. Substantial data also
indicates the involvement of secondary processes, such as inflammation
and inflammatory-induced oxidative stress, as possible mechanisms for
the rat lung tumor response. Furthermore, recent studies have highlighted
the impact of particle size and surface area on these processes. Along with
the effects observed in the lower respiratory tract, it has recently become
apparent that nasal tissue is also an important target for particle-induced
toxicity. The current information regarding the roles of particle surface
area, tissue retention, and chronic inflammation in response has contributed
to an improved mechanistic understanding of the rat lung tumor response to
Wednesday, March 8
1:30 PM to 4:30 PM
Room 6C
SYMPOSIUM SESSION: THE PATH FOR ASSESSING HUMAN
RELEVANCE AND ADVANCING NEW SAFETY BIOMARKERS
FOR DRUG-INDUCED VASCULAR INJURY
Chairperson(s): Denise Robinson, Pfizer Global Research &
Development, New London, CT and Frank Sistare, Merck & Co Inc., West
Point, PA.
Endorsed by:
Mechanisms SS
Risk Assessment SS
Treatment related vascular injury is a significant pre-clinical safety issue
for the pharmaceutical industry. Noninvasive methods for early detection
in animal studies and for monitoring patients to assess in clinical trials
the human relevance of pre-clinical findings remain a vital unmet need.
The observation of vascular injury during toxicity testing in animals,
may stop or delay compound development and/or limit the allowable
clinical dose range, thereby limiting the development or the therapeutic uses of a product. The clinical advance of compounds that produce
208
45th Annual
Meeting & ToxExpo
vascular injury pre-clinically has also been slowed by the lack of clear
regulatory guidance. Sensitive and specific biomarkers as well as experimental approaches that provide a better understanding of the mechanisms
that produce vascular injury in pre-clinical models, are needed to assess
relevance for human risk, to manage the risk rationally, and ensure
clinical trial safety. Just as important as the science is the process for
gaining scientific and regulatory acceptance around the validity and
appropriate clinical investigative application of any such new biomarkers. This session will highlight the latest advances in our mechanistic
understanding of the pathways of vascular injury in various pre-clinical
models, and introduce novel approaches to assessing and monitoring
vascular compromise. The focus will be on what we can do with what
we know now, given the regulatory impetus to drive the qualification
and application of new biomarker technologies for safety assessment.
1:30
THE PATH FOR ASSESSING HUMAN
RELEVANCE AND ADVANCING NEW
SAFETY BIOMARKERS FOR DRUG
INDUCED VASCULAR INJURY. D. Robinson1
and F. Sistare2. 1Worldwide Safety Sciences, Pfizer,
New London, CT and 2Laboratory Sciences and
Investigative Toxicology, Merck & Co., Inc., West
Point, PA.
#1855
1:35
PATHWAYS FOR DAMAGE TO THE
VASCULATURE. J. R. Bender1 and B. Enerson2,
1 1
. Medicine, Yale University, new haven, CT and
2
Pfizer Pharmaceuticals, Groton, CT.
#1856
2:05
DRUG-INDUCED VASCULITIS: FDA’S
PERSPECTIVE AND THE PATH FORWARD.
T. Papoian and F. Goodsaid. U.S. Food and Drug
Administration, Rockville, MD. Sponsor: D.
Robinson-Gravatt.
#1857
#1858
#1859
2:40
3:00
3:20
SYMPOSIUM SESSION: ROLE OF EPIGENETICS IN THE FETAL
BASIS OF ADULT DISEASE
Chairperson(s): Jerrold Heindel, NIEHS, Research Triangle Park, NC and
Retha Newbold, NIEHS, Research Triangle Park, NC.
Endorsed by:
Carcinogenesis SS
Mechanisms SS
Reproductive and Development SS*
There is increasing evidence that some environmental agents, especially
those with endocrine agonist or antagonist activity, may alter developmental programming via alteration in gene expression that do not result
in malformations but in functional deficits. These functional deficits in
tissue potential are expressed later in life as increased susceptibility to
disease/dysfunction. In some cases the functional deficits have been shown
to be transmitted to the next generations(s). The mechanism proposed
for this phenomenon, termed the fetal basis of adult disease, is believed
to be epigenetic alterations in gene expression probably via altered DNA
methylation. The talks in this session will highlight examples of in utero
exposures resulting in increased diseases later in life. In some instances
transgenerational effects due to in utero exposures to environmental agents
can be shown. An overview of epigenetics with an emphasis on how it
might contribute to the adult diseaases and the transgenerational effects of
these in utero exposures will also be presented.
NOVEL BIOMARKERS OF DRUG-INDUCED
VASCULAR INJURY. C. S. Louden1, D.
Brott1, S. Gould1, A. Katein1, T. Kelley1 and
H. Jones1. 1Safety Assessment, AstraZeneca
Pharmaceuticals, Merside, Alderley Park, United
Kingdom, 2Safety Assessment, Astrazeneca
Pharmaceuticals, Wilmington DE, DE, 3Safety
Assessment, Astrazeneca Pharmaceuticals, Merside,
Alderley, United Kingdom, 4Safety Assessment,
Astrazeneca Pharmaceuticals, Wilmington, DE,
5
Safety Assessment, Astrazeneca Pharmaceuticals,
Wilmington DE, DE and 6Safety Assessment,
Astrazeneca Pharmaceuticals, Merside, Alderley
Park, United Kingdom.
TOWARD AN UNDERSTANDING OF
DRUG-INDUCED VASCULAR INJURY:
HISTOPATHOLOGICAL AND GENE
EXPRESSION CORRELATES. R. D. Snyder1 and
J. Zhang2. 1Investigative and Molecular Toxicology,
Schering-Plough Research Institute, Lafayette, NJ
and 2CDER, USFDA, Silver Spring, MD.
A SYSTEMS BIOLOGY APPROACH TO
UNDERSTAND MECHANISMS OF DRUGINDUCED VASCULAR INJURY. E. Floyd1,
J. Pollard2, O. Beckonert1, S. Beushausen1, S.
Chevalier1, F. Clemo1, N. Dagues1, B. Duckworth2,
G. Hanton1, W. Ladd2, M. Neuberg2, V. Pawlowski1,
D. Pratt2, M. Reily1, D. Robertson1, D. Robinson1, T.
Slater1, C. Sobry1 and M. Lawton1. 1Pfizer, Inc., New
London, CT and 2Genstruct, Inc., Cambridge, MA.
209
#1860
1:30
ROLE OF EPIGENETICS IN THE FETAL
BASIS OF ADULT DISEASE. J. J. heindel1, R.
Newbold1, T. K. Archer1, M. Skinner2, C. Walker4 and
R. Jirtle3. 1NIEHS/NIH/DHHS, Research Triangle
Park, NC, 2Washington State University, Pullman,
WA, 3Duke University, Durham, NC and 4University
of Texas MD Anderson Cancer Center, Smithville,
TX.
#1861
1:40
REGULATING THE GENOME WITH
CHROMATIN AND EPIGENETIC CHANGES.
T. Archer. NIEHS/NIH, Research Triangle Park, NC.
Sponsor: J. Heindel.
#1862
2:30
EPIGENETIC TRANSGENERATIONAL
EFFECTS OF ENDOCRINE DISRUPTORS ON
MALE FERTILITY AND OTHER DISEASES.
M. Skinner. Washington State University, Pullman,
WA. Sponsor: J. Heindel.
#1863
3:10
DEVELOPMENTAL PROGRAMMING:
UNDERSTANDING HOW EARLY LIFE
ENVIRONMENTAL EXPOSURES
DETERMINE CANCER INCIDENCE IN
ADULTS. C. Walker. Carcinogenesis, MD Anderson
Cancer Center, Smithville, TX.
#1864
3:50
EPIGENETIC TARGETS LINKING
PRENATAL NUTRITION WITH ADULT
DISEASE SUSCEPTIBILITY. R. Jirtle. Duke
University, Durham, NC. Sponsor: J. heindel.
WEDNESDAY
#1854
Wednesday, March 8
1:30 PM to 4:30 PM
Room 5A
45th Annual
Meeting & ToxExpo
Wednesday, March 8
1:30 PM to 4:30 PM
Room 8
WORKSHOP SESSION: HORMESIS: A CHALLENGE TO THE
LINEAR DOSE-RESPONSE MODEL, AND ITS IMPLICATIONS IN
RISK ASSESSMENT, REGULATORY POLICY, AND BIOMEDICAL
RESEARCH
#1868
2:50
REGULATORY AND LEGAL IMPLICATIONS
OF HORMESIS. G. E. Marchant. College of Law,
Arizona State University, Tempe, AZ.
#1869
3:25
WHAT ARE THE CLINICAL IMPLICATIONS
OF HORMESIS? W. B. Jonas. Samueli Institute,
Alexandria, VA. Sponsor: E. Calabrese.
#1870
4:00
MAINSTREAMING HORMESIS. D.
Paustenbach and J. S. Pierce. ChemRisk, San
Francisco, CA.
Chairperson(s): Dennis Paustenbach, ChemRisk Inc., San Francisco, CA
and Jennifer Pierce, ChemRisk Inc., San Francisco, CA.
Wednesday, March 8
1:30 PM to 4:30 PM
Room 7A
Endorsed by:
Risk Assessment SS
Hormesis remains a controversial topic in the fields of toxicology and risk
assessment. The reason, is that if the phenomenon generally exists for all
toxic effects and all chemicals, this would put current approaches to regulating chemicals into question. For carcinogens, there would need to be
a re-evaluation of the current view that the linear dose-response relationship is most appropriate, and instead, a biphasic model would probably be
considered most appropriate (with inclusion of a threshold). In addition,
some chemicals with carcinogenic effects might reduce risk for cancer at
certain exposure levels. For the chemicals whose most sensitive adverse
effects are not cancer, a change in the approach for identifying the No
Adverse Effect Level (NOAEL) would be necessary. This symposium will
provide a comprehensive overview of hormesis, and its potential impacts
on risk assessment and regulatory policy, as well as its impact on chemotherapeutics. The legal hurdles to implementing such an approach will be
discussed. In addition, the various changes in toxicology testing protocols
that would be necessary to insure that hormesis is incorporated into regulatory decision making will be discussed. The practical consequences of
adopting the concept of hormesis, specifically with respect to the remediation of contaminated sites, setting of drinking water standards, and
other regulatory risk criteria will be described. A physician will discuss the
impact of hormesis on future biomedical and clinical research. The goal of
this symposium is to bring together perspectives on this topic from various
fields, and initiate a dialogue between those in support of and against the
adoption of the hormetic dose-response model. Further, it will provide the
toxicology community with the knowledge of one of the most contemporary, yet historically rooted debates among the scientific community.
#1865
1:30
HORMESIS: A CHALLENGE TO THE
LINEAR DOSE-RESPONSE MODEL, AND
ITS IMPLICATIONS IN RISK ASSESSMENT,
REGULATORY POLICY, AND BIOMEDICAL
RESEARCH. D. J. Paustenbach1, E. Calabrese2, K.
Bogen3, G. Marchant4 and W. Jonas5. 1ChemRisk,
San Francisco, CA, 2Environmental Health Sciences,
University of Massachusetts Amherst School of
Public Health, Amherst, MA, 3Lawrence Livermore
National Laboratory, Livermore, CA, 4Center
for Law, Science, & Technology, Arizona State
University College of Law, Tempe, AZ and 5Samueli
Institute, Alexandria, VA.
WEDNESDAY
#1866
1:35
HORMESIS: SCIENTIFIC FOUNDATIONS.
E. J. Calabrese. Public Health, University of
Massachusetts, Amherst, MA.
#1867
2:15
CANCER RISK AND HORMESIS:
PLAUSIBILITY AND IMPLICATIONS.
K. T. Bogen. Energy & Environment L-396,
Lawrence Livermore National. Laboratory/
University California, Livermore, CA. Sponsor: D.
Paustenbach.
WORKSHOP SESSION: INTEGRATING BIOMONITORING INTO
EPIDEMIOLOGY AND TOXICOLOGY RESEARCH
Chairperson(s): James Bus, Dow Chemical Company, Midland, MI and
Leonard Ritter, Canadian Network of Toxicology Centres, Guelph, ON,
Canada.
Endorsed by:
Epidemiology has well established methods for conducting research using
questionnaires on self-reported exposure. Categories of exposure and
intensity algorithms have been developed to determine the dose response
of the putative health effect. Toxicology has also developed sophisticated
pharmacokinetic models and dosing methods by which to evaluate hazards
of specific chemicals or pesticides. Between the two disciplines epidemiology and toxicology, however, lies a growing body of biomonitoring data
capturing real-world human exposures. Emerging data from both the CDC
National Exposure Report and other similar studies presents an opportunity to better integrate complex exposure/dose metrics into improved
evaluations of human health risks. The objectives of this workshop will
examine several key questions addressing this task. A critical weakness
in modern epidemiology is the lack of validation of exposure. Can survey
methodology in agricultural epidemiology studies be improved from information obtained from recent exposure biomonitoring studies of farmers?
How can detected levels of chemicals in the human population be better
corresponded to dose/exposure metrics in animal toxicology studies so that
findings of biomonitoring studies can be better related to potential adverse
health outcomes? Lastly, how can biomonitoring, epidemiology and pharmacokinetic tools be improved to better link traditional external exposure
measures to actual measures of internal tissue doses?
210
#1871
1:30
INTEGRATING BIOMONITORING INTO
EPIDEMIOLOGY AND TOXICOLOGY
RESEARCH. J. S. Bus1, C. Burns1 and L. Ritter2.
1
Toxicology & Environmental Research and
Consulting, Dow Chemical Company, Midland,
MI and 2Canadian Network of Toxicology Centres,
University of Guelph, Guelph, ON, Canada.
#1872
2:05
TOXICOLOGY STUDY DESIGN AND
DOSIMETRY AS IT RELATED TO
BIOMONTORING AND EPIDEMIOLOGY
STUDIES. A. J. Tobia. Toxicology, Bayer
CropSceince, Research Triangle Park, NC.
#1873
2:40
BIOMARKERS OF EXPOSURE TO
CHEMICALS: LESSONS LEARNT FROM
EPIDEMIOLOGY. T. E. Arbuckle. Biostatistics
and Epidemiology Division, Health Canada, Ottawa,
ON, Canada. Sponsor: L. Ritter.
45th Annual
Meeting & ToxExpo
#1874
3:15
STRENGTHS AND WEAKNESSES OF
COLLECTING EXPOSURE DATA FROM
QUESTIONNAIRES. P. Buffler2 and C. J. Burns1.
1
Epidemiology, The Dow Chemical Company,
Midland, MI and 2School of Public Health,
University California, Berkeley, Berkeley, CA.
#1881
3:10
3-METHYLINDOLE-INDUCED DNA
DAMAGE LEADS TO CYTOTOXICITY
AND P53 NUCLEAR LOCALIZATION. J. M.
Weems, N. S. Cutler, W. K. Nichols and G. S. Yost.
Pharmacology and Toxicology, University of Utah,
Salt Lake City, UT.
#1875
3:50
USE OF PHYSIOLOGICALLY BASED
PHARMACOKINETIC MODELING TO
CHARACTERIZE EXPOSURES ASSOCIATED
WITH BIOMONITORING DATA. R. Conolly1,
K. H. Liao2 and Y. Tan2. 1National Center for
Computational Toxicology, U.S. EPA, Research
Triangle Park, NC and 2Center for Human Health
Assessment, CIIT Centers for Health Research,
#1882
3:30
DIFFERENTIAL FORMATION OF
ESTROGEN AND ESTRADIOL BY
PLACENTAL AROMATASE. J. Schulze2,
M. Schulze1 and C. Siegers1. 1Department of
Experimental and Clinical Pharmacology and
Toxicology, Luebeck, Germany and 2Office of the
Dean, Frankfurt/Main, Germany.
#1883
3:50
DONG QUAI INHIBITS HUMAN
CYTOCHROMES P450 IN VITRO. H. E. Kleiner1,
2
and A. Keller3, 1. 1Pharmacology, Toxicology,
& Neuroscience, Louisiana State UniversityHealth Sciences Center, Shreveport, LA, 2Cancer
Prevention & Control, Feist-Weiller Cancer Center,
Shreveport, LA and 3Caddo Magnet High School,
Shreveport, LA.
#1884
4:10
THE TOXICOLOGICAL MECHANISM OF
STYRENE IN CYP2E1 TRANSGENIC CELLS.
J. Chung, W. Yuan and J. Zheng. Pharmaceutical
Sciences, Northeastern University, Boston, MA.
Wednesday, March 8
1:30 PM to 4:30 PM
Room 7B
PLATFORM SESSION: BIOTRANSFORMATION
Chairperson(s): Garold Yost, University of Utah, Salt Lake City, UT
and Mary Beth Genter, University of Cincinnati, Environmental Health,
Cincinnati, OH.
1:30
ROLE OF THE ARYL HYDROCARBON
RECEPTOR PATHWAY IN THE
SYNERGISTIC DEVELOPMENTAL
TOXICITY OF POLYCYCLIC AROMATIC
HYDROCARBONS IN ZEBRAFISH. R.
Di Giulio1, S. Billiard1, A. Timme-Laragy1, D.
Wassenberg2, C. Cockman1 and E. Linney2,
1 1
. Nicholas School of the Environment, Duke
University, Durham, NC and 2Department of
Molecular Genetics and Microbiology, Duke
#1877
1:50
ROLE OF AHR AND CYP1A1 IN
NAPHTHALENE BIOACTIVATION. M. Genter,
J. Marlowe, N. Dragin, J. K. Kerzee, A. Puga, D.
W. Nebert and T. P. Dalton. Environmental Health,
#1878
2:10
STUDIES OF THE MECHANISMS OF
TOXICITY OF POLYBROMINATED
DIPHENYL ETHERS (PBDEs). J. M. Sanders1,
2
, L. Chen1, E. H. Lebetkin1, M. L. Cunningham1
and L. T. Burka1. 1Laboratory of Pharmacology and
Chemistry, NIEHS, Research Triangle Park, NC and
2
Department of Toxicology, NC State University,
Raleigh, NC.
#1879
#1880
2:30
2:50
Wednesday, March 8
1:30 PM to 4:30 PM
Room 15A
PLATFORM SESSION: BIOINFORMATICS AND BIOLOGICAL
MODELING
Chairperson(s): Charles Wang, University of California - Los Angeles, Los
Angeles, CA and Harvey Clewell, CIIT, Research Triangle Park, NC.
CYP1C1 mRNA EXPRESSION IN FUNDULUS
FOLLOWING BAP EXPOSURE. L. Wang1, B.
E. Scheffler2, W. Dong1, A. Ford1 and K. L. Willett1.
1
Pharmacology and Environmental Toxicology,
2
MSA Genomics Laboratory, USDA-ARS-CGRU,
Stoneville, MS.
IN VIVO MUTAGENICITY OF VINYL
CARBAMATE IN LUNG AND VARIOUS
TISSUES. L. G. Hernandez and P. Forkert. Anatomy
and Cell Biology, Queen’s University, Kingston, ON,
Canada.
211
#1885
1:30
EVALUATION OF THE TUMOR DOSERESPONSE FOR PROPYLENE OXIDE
USING CFD MODELING AND THE 2-STAGE
CLONAL GROWTH MODEL. Y. Tan, J. S.
Kimbell, R. B. Conolly and H. J. Clewell. CIIT
Park, NC.
#1886
1:52
DEVELOPMENT OF A REVERSE
DOSIMETRY SCREENING APPROACH
FOR THE INTERPRETATION OF
BIOMONITORING DATA ON VOLATILE
ORGANIC COMPOUNDS. H. J. Clewell, Y.
Tan and K. H. Liao. Center for Human Health
Assessment, CIIT Centers for Health Research,
#1887
2:14
TOXICITY PREDICTION TOOLS FOR
ENDOCRINE DISRUPTION. M. A. Pasquinelli,
S. B. Little and J. R. Rabinowitz. National Center
for Computational Toxicology, U.S. EPA, Research
Triangle Park, NC.
WEDNESDAY
#1876
45th Annual
Meeting & ToxExpo
#1888
#1889
#1890
2:36
2:58
3:20
INTEGRATING TRANSCRIPTOMICS WITH
CYTOTOXICITY FOR IDENTIFICATION
OF BIOMARKERS IN PRIMARY RAT
HEPATOCYTES EXPOSED TO CADMIUM.
C. Wang1, 2, Y. Tan1, J. Xu1, L. Shi3, S. M. Hussain4
and J. M. Frazier4. 1Cedars-Sinai Research Institute,
Cedars-Sinai Medical Center, Los Angeles, CA,
2
Department of Medicine, UCLA, Los Angeles, CA,
3
Center for Toxicoinformatics, National Center for
Toxicological Research, Jefferson, AR and 4Applied
Biotechnology, U.S. Air Force Research Laboratory,
Wright-Patterson AFB, OH.
A SMALL NUMBER OF GENES ARE
SUFFICIENT TO CLASSIFY A LARGE
NUMBER OF UNIQUE TOXICOLOGICAL
AND PHARMACOLOGICAL END-POINTS
USING GENE EXPRESSION. G. Natsoulis,
A. Tolley, J. Retief, B. Ganter, A. Engelberg, R.
Brennan and K. Jarnagin. Iconix Pharmaceuticals,
Mountain View, CA.
ELUCIDATION OF A GENE REGULATORY
NETWORK FOR FOREBRAIN
DEVELOPMENT USING BIOINFORMATICS
APPROACHES FOR THE ANALYSIS OF
COMPILED MICROARRAY DATASETS. J.
M. Gohlke1, F. M. Parham1, J. S. Parker2, M. V.
Smith2 and C. J. Portier1. 1Laboratory of Molecular
Toxicology, NIEHS, Research Triangle Park, NC
and 2Constella Health Sciences, Durham, NC.
#1891
3:42
COMMON GENE NETWORKS AT MOUSE
LIVER EXPOSED TO CARCINOGENS. H.
Toyoshiba and H. Sone. NIES, Tsukuba, Japan.
#1892
4:04
SYSTEMS BIOLOGY APPROACH FOR
ELUCIDATING MECHANISM OF TOXICITY.
G. Apic1 and R. Russell2. 1Cambridge Cell Networks
Ltd., Cambridge, United Kingdom and 2European
Molecular Biology Laboratory, Heidelberg,
Germany. Sponsor: S. Boyer.
Wednesday, March 8
1:30 PM to 4:30 PM
Room 5B
#1894
1:50
SYNERGISTIC EFFECT OF BACTERIAL
LIPOPOLYSACCHARIDE ON
ACETAMINOPHEN-INDUCED PRODUCTION
OF CYTOKINES IN THE RAW 264.7 MOUSE
MACROPHAGE CELL LINE. S. Lacour1, 2, J.
Gautier1 and M. Pallardy2. 1Drug Safety Evaluation,
sanofi aventis, Alfortville, France and 2Faculte
de Pharmacie, INSERM UMR-S 461, ChatenayMalabry, France.
#1895
2:10
2, 3, 7, 8-TETRACHLORODIBENZO-pDIOXIN (TCDD) REQUIRES THE HELP
OF DENDRITIC CELLS OR MITOGEN TO
INDUCE APOPTOSIS IN PRIMARY T CELLS
AND ESTABLISHED T CELL LINE IN VITRO.
N. P. Singh, M. Nagarkatti and P. Nagarkatti.
Pathology & Microbiology, University of South
Carolina, Columbia, SC.
#1896
2:30
MICROARRAY ANALYSIS OF BIS(TRIN-BUTYLTIN)OXIDE (TBTO) INDUCED
IMMUNOTOXICITY. K. Baken1, 2, J. Pennings2,
H. van Steeg2, 3 and H. van Loveren2, 1. 1Health Risk
Analysis and Toxicology, Maastricht University,
Maastricht, Netherlands, 2Toxicology, Pathology
and Genetics, RIVM, Bilthoven, Netherlands and
3
Toxicogenetics, LUMC, Leiden, Netherlands.
#1897
2:50
IMMUNE FUNCTION IN RATS
DEVELOPMENTALLY EXPOSED TO
DIBUTYLTIN DICHLORIDE. J. DeWitt1,
C. Copeland2 and R. Luebke2. 1Curriculum in
Toxicology, UNC, Chapel Hill, NC and 2ORD/
NHEERL/ETD/ITB, U.S. EPA, Research Triangle
Park, NC.
#1898
3:10
THE LUNG, NOT THE IMMUNE SYSTEM,
IS THE TARGET OF AHR-MEDIATED
EVENTS THAT ENHANCE INNATE IMMUNE
RESPONSES TO RESPIRATORY VIRAL
INFECTION. S. Teske, H. Neff-LaFord and B.
Lawrence. Pharmaceutical Sciences, Washington
State University, Pullman, WA.
#1899
3:30
IMMUNOTOXICITY OF A PESTICIDE
MIXTURE: MECHANISM OF GREATER
THAN ADDITIVE INHIBITION OF
CYTOKINE PRODUCTION. S. B. Pruett, C.
Schwab, Q. Zheng and R. Fan. Cellular BIology &
Anatomy, LSU Health Sciences Center, Shreveport,
LA.
#1900
3:50
EXAMINATION OF A POTENTIAL
ESTROGENIC MODE OF ACTION FOR
CHLORDECONE ACCELERATION OF
AUTOIMMUNITY IN NZBXNZW/F1 MICE. F.
Wang, S. M. Roberts and E. S. Sobel. University of
#1901
4:10
ENVIRONMENTAL CONTAMINANT
TRICHLOROETHYLENE PROMOTES
AUTOIMMUNE DISEASE AND INHIBITS
T CELL APOPTOSIS. K. Gilbert1, N. Pumford2
and S. Blossom1. 1Microbiology and Immunology,
University of Arkansas for Medical Sciences/
Arkansas Children’s Hospital Research Institute,
Little Rock, AR and 2Cell and Molecular Biology
Program, University of Arkansas, Fayetteville, AR.
PLATFORM SESSION: IMMUNOTOXICITY
Chairperson(s): Kathleen Gilbert, University of Arkansas for Medical
Sciences, Little Rock, AR and Robert Luebke, U.S. EPA, Research Triangle
Park, NC.
#1893
1:30
WEDNESDAY
ETHANOL DIMINISHES LPS-INDUCED
TLR4/CD14 RECEPTOR CLUSTERING AND
ASSOCIATED CHANGES IN THE ACTIN
CYTOSKELETON AND ACCUMULATION
OF MEMBRANE BOUND AND SECRETED
TNF-ALPHA. Q. Dai and S. B. Pruett. Cellular
Shreveport, LA.
212
45th Annual
Meeting & ToxExpo
Wednesday, March 8
1:30 PM to 4:30 PM
Room 2
#1908
3:42
HIGH THROUGHPUT SCREENING OF
MITOCHONDRIAL RESPIRATION USING
OXYGEN SENSING FLUORESCENCE
PROBES. L. D. Marroquin1, K. Christiansen1, J.
Hynes2, D. Papkovsky2, G. Stevens1 and Y. Will1.
1
Safety Sciences, Pfizer, San Diego, CA and
2
Luxcel, Cork, Ireland.
#1909
4:04
MITOCHONDRIAL DYSFUNCTION CAN
EASILY BE DETECTED IN GALACTOSE
GROWN CELLS USING OXYGEN SENSING
FLUORESCENCE PROBES. L. D. Marroquin1,
J. Hynes2, D. Papkovsky2, G. Stevens1 and Y. Will1.
1
Safety Sciences, Pfizer, San Diego, CA and
2
Luxcel, Cork, Ireland.
PLATFORM SESSION: PREDICTING COMPOUND TOXICITY
Chairperson(s): William Brock, Brock Scientific Consulting LLC,
Montgomery Village, MD and Douglas A. Keller, sanofi-aventis, Malvern,
PA.
1:30
EFFECT BASED CLASSIFICATION SCHEME
FOR IN VITRO DATA TO PREDICT ACUTE
RODENT TOXICITY. A. Freidig, S. Dekkers,
J. Bessems, M. Verwei and H. van de Sandt. TNO
Quality of Life, Zeist, Netherlands.
#1903
1:52
DEVELOPING KNOWLEDGE OF
STRUCTURE-ACTIVITY RELATIONSHIPS
IN TOXICITY. N. Greene1, B. Acar-Chiaradia2,
C. McKay2, C. A. Marchant2, R. R. Note2 and M.
L. Patel2. 1Safety Sciences - Groton, Pfizer Global
Research & Development, Groton, CT and 2Lhasa
Limited, Leeds, United Kingdom.
#1904
#1905
#1906
#1907
2:14
2:36
2:58
3:20
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: CHEMICAL-BIOLOGICAL WEAPONS II
Chairperson(s): Richard Gordon, Walter Reed Army Institute of Research,
Silver Spring, MD.
MODELING AND INFORMATICS SUPPORT
FOR SAFETY STUDIES IN EARLY DRUG
DISCOVERY PROJECTS. S. C. Boyer, S.
W. Ernst, M. Graham and G. J. Oliver. Global
Safety Assessment, AstraZeneca R&D Moelndal,
Moelndal, Sweden.
THREE DISTINCT PHARMACOLOGIC
AGENTS ASSOCIATED WITH HUMAN
IDIOSYNCRATIC HEPATOTOXICITY
DISPLAY COMMONALITIES IN GENE
EXPRESSION PROFILES IN LPS COTREATED RATS. M. J. Liguori1, J. F. Waring1, J.
P. Luyendyk2, X. Deng2, J. F. Maddox2, P. E. Ganey2,
R. F. Stachlewitz1, E. A. Blomme1, W. B. Mattes3, G.
N. Cosma3 and R. A. Roth2. 1Department of Cellular
and Molecular Toxicology, Abbott Laboratories,
Abbott Park, IL, 2Department of Pharmacology
Lansing, MI and 3Pharmacia, Inc., Skokie, IL.
THE POSSIBILITY OF CHEMICAL
COMPUTATION APPROACHES TO DRUDS
PHOTOSAFETY EVALUATION. Y. Zhou1, H.
Yamada1, M. Sakimura1, M. Fujikawa1, I. Horii1
and A. Ishibashi2. 1Safety Sciences, Pfizer Global
Reseach & Development, Nagoya Laboratory,
Taketoyo, Aichi, Japan and 2Computational
Chemistry and Structural Sciences, Pfizer Global
Reseach & Development, Nagoya Laboratory,
Taketoyo, Aichi, Japan.
HUMAN PBMCS AS AN IN VITRO MODEL
FOR PREDICTING COMPOUND TOXICITY.
N. Patil1, L. Brady1, S. Brown1, N. Faravashi1, E.
A. Blomme2, J. F. Waring2, Y. Yang2, S. J. Abel2, B.
Eynon1, S. Fujimoto1, K. Kolaja1, D. N. Halbert1 and
G. Day1. 1Iconix Pharmaceuticals, Inc., Mountain
View, CA and 2Abbott Laboratories, Abbott Park,
IL.
213
#1910
PROTECTIVE EFFECT OF A SMALL
PEPTIDE AGAINST SULFUR MUSTARDINDUCED LESIONS. Universtiy of. Wormser,
Y. Schussheim, A. Rosengarten, I. Shapira and B.
Brodsky. Pharmacology, The Hebrew University,
Jerusalem, Israel.
#1911
THE DETECTION OF FREE RADICAL
FORMATION FROM THE INTERACTION
OF SULFUR MUSTARD WITH NADPH
- CYTOCHROME P450 REDUCTASE. A. A.
Brimfield1, M. J. Novak2, A. M. Mancebo1, B. S.
Gallagher1 and C. M. Arroyo1. 1pharmacology
branch, U.S. Army Medical Research Institute of
Chemical Defense, APG/EA, MD and 2Chemistry,
Florida Institute of Technology, Melbourn, FL.
#1912
INTERACTION OF SULFUR MUSTARD WITH
NADPH-CYTOCHROME P450 REDUCTASE
AND CYTOCHROME P450 ISOFORMS. A.
M. Mancebo and A. A. Brimfield. Pharmacology
Branch, U.S. Army Medical Research Institute of
Chemical Defense, APG/EA, MD.
#1913
REDUCTION OF MECHLORETHAMINE
CYTOTOXICITY BY EBSELEN IN
NORMAL AND TUMOR-DERIVED CELL
LINES. D. Hardej and B. Billack. Department of
Pharmaceutical Sciences, St. John’s University,
Queens, NY.
#1914
ENDOTHELIAL CELL ALTERATIONS
FOLLOWING IN VITRO EXPOSURE
TO SULFUR MUSTARD OR PLATELET
ACTIVATING FACTOR. O. E. Clark, E. W.
Nealley, K. Leiter, A. L. Miller, J. D. Nicholson
and W. J. Smith. Research Division, USAMRICD,
WEDNESDAY
#1902
45th Annual
Meeting & ToxExpo
#1915
UPREGULATION OF THE GAMMA-2 CHAIN
OF LAMININ-332 (LAMININ-5) IN SULFUR
MUSTARD TREATED MOUSE SKIN. D. R.
Gerecke, R. A. Hahn, M. K. Gordon and Y. Chang.
Joint Graduate Program in Toxicology, Ernest Mario
School of Pharmacy, Rutgers University, Piscataway,
NJ.
#1922
AFFECT OF TEMPERATURE AND
RELATIVE HUMIDITY ON THE TEMPORAL
INACTIVATION OF RICIN ON INDOOR
SURFACE MATERIALS. E. Marsh1, J. Rogers1, H.
Stone1, B. Martin2 and S. Ryan2. 1Battelle Memorial
Institute, Columbus, OH and 2U.S. Environmental
Protection Agency, Research Triangle Park, NC.
#1916
PULMONARY BIOCHEMICAL
ALTERATIONS INDUCED BY SYSTEMIC
ADMINISTRATION OF NITROGEN
MUSTARD. N. Elsayed1, 2 and S. Omaye3.
1
Scientific Affairs, Hurley Consulting Associates,
Chatham, NJ, 2Anatomy and Cell Biology, SUNY
Downstate Medical Center, Brooklyn, NY and
3
Nutrition, University of Nevada, Reno, NV.
#1923
SUPERFICIAL DERMAL CHEMICAL BURN
MODEL IN THE WEANLING PIG. F. Reid1, J.
Graham1, N. Niemuth1, M. Matthews1, T. Hoffman1,
B. Hart1, D. Vasconcelos1 and R. Casillas1. 1Battelle
Memorial Institute, Columbus, OH and 2Medical
Toxicology Branch, Analytical Toxicology Division,
U.S. Army Medical Research Institute of Chemical
Defense, Aberdeen Proving Ground, MD.
#1917
CYTOSKELETAL TARGETS AND PATHWAYS
DAMAGED BY SULFUR MUSTARD. R. J.
Werrlein, C. R. Braue, C. S. Phillips and J. F.
Dillman. Cell and Molecular Biology Branch,
#1924
#1918
FEASIBILITY OF USING THE CYANIDE
METABOLITE 2-AMINOTHIZOLINE-4CARBOXYLIC ACID AS A RETROSPECTIVE
MARKER OF CYANIDE EXPOSURE. W.
Maserek-Ruud1, G. A. Rockwood2, S. I. Baskin2,
G. E. Platoff2 and B. A. Logue1. 1Chemistry and
Biochemistry, South Dakota State University,
Brookings, SD and 2US Army Medical Research
Institute of Chemical Defense, Aberdeen Proving
Ground, MD.
CHEMICAL WARFARE AGENTS
(ORGANOPHOSPHATES AND VESICANT)
AND BIOLOGICAL DECONTAMINATION
AND DETOXIFICATION USING
POLYURETHANE SPONGES. R. Gordon1, K.
Baker1, L. Askins1, R. Ratcliffe1, D. Lindsay1, R.
Owens1, B. Doctor1, E. Clarkson2, L. Mitcheltree2,
S. Schulz2, M. Shutz2, A. Douglas2, C. Kelleher2,
K. Newkirk2, N. Washington2 and R. Railer2.
1
Division of Biochemistry, Department Biochemical
Pharmacology, Walter Reed Army Institute of
Research, Silver Spring, MD and 2US Army Medical
Research Institute of Chemical Defense, Aberdeen
Proving Ground, MD. Sponsor: M. Nambiar.
#1925
CHEMICAL WARFARE AGENT TOXICITY
ESTIMATES FOR THE GENERAL
POPULATION. D. R. Sommerville1, S. A. Reutter1,
R. B. Crosier1, E. E. Shockley1 and J. J. Bray2. 1US
Army Edgewood CB Center, Aberdeen Proving
Ground, MD and 2Optimetrics, Inc., Bel Air, MD.
#1926
EVALUATING THE VISUAL SAMPLING PLAN
STATISTICAL TESTS FOR DETECTING
THE PRESENCE OF BIOTHREAT AGENTS:
CONSIDERING THE EFFECTS OF
POSITIVELY-SKEWED DISTRIBUTIONS
AND SPATIAL AUTOCORRELATION ON
NOMINAL TYPE I AND II ERROR RATES.
W. Thayer1, T. Negley1, P. Coleman1, P. McGinnis1,
D. A. Gray1, T. Nichols2 and C. Sonich-Mullin2.
1
Environmental Science Center, Syracuse Research
Corp, Syracuse, NY and 2National Homeland
Security Research Center, Environmental Protection
Agency, Cincinnati, OH.
#1927
EMERGENCY RESPONSE: THE ACTIVE
AND CRUCIAL ROLE OF TOXICOLOGISTS.
S. B. DuTeaux and C. A. Caraway. Office of
Environmental Health Hazard Assessment, Cal EPA,
Sacramento, CA.
#1919
#1920
#1921
EFFECTS OF HEAVY METALS ON
CYANIDES. S. E. Czerwinski1, 3 and S. I. Baskin2.
1
Directorate of Laboratory Sciences, U.S. Army
Center for Health Promotion and Preventive
Medicine, Aberdeen Proving Ground, MD,
2
Pharmacology Division, U.S. Army Medical
Research Institute of Chemical Defense, Aberdeen
Proving Ground, MD and 3Department of
Pharmacology, University of Maryland, Baltimore,
Baltimore, MD.
ACUTE RDX EXPOSURE AND GENE
EXPRESSION IN THE RAT BRAIN. D. I.
Bannon1, J. F. Dillman2, E. J. Perkins3, W. Bao4, R. D.
Wolfinger4, T. Chu4 and C. S. Phillips2. 1Directorate
of Toxicology Army Center for Health Promotion
MD, 2Applied Pharmocology and Neurotoxicology
Branches Army Medical Research Institute of
Chemical Defense, Aberdeen Proving Ground,
MD, 3Molecular Ecology Team, Environmental
Laboratory Army Engineering Research and
Development Center, Vicksburg, MS and 4SAS
Institute Inc., Cary, NC.
WEDNESDAY
FLOW CYTOMETRIC ANALYSIS OF
PROTECTIVE ANTIGEN-STIMULATED
T CELL CYTOKINE PRODUCTION AND
PROLIFERATION IN RHESUS MACAQUES
CHALLENGED WITH AEROSOLIZED
BACILLUS ANTHRACIS SPORES. S. Casbohm,
E. B. Delpit, J. P. Long, P. H. Olson, R. E. Barnewall,
R. E. Hunt, R. D. LeClaire, J. E. Estep, P. J. Sabourin
and C. L. Sabourin. Battelle Memorial Institute,
Columbus, OH.
214
45th Annual
Meeting & ToxExpo
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
#1934
IN-VIVO ESTROGENIC AND
ANTIESTROGENIC EFFECTS OF THE PBDE
MIXTURE DE-71. M. Mercado Feliciano1 and R.
M. Bigsby2. 1Pharmacology and Toxicology, Indiana
University, Indianapolis, IN and 2Obstetrics and
Gynecology, Indiana University, Indianapolis, IN.
#1935
TRANSCRIPTIONAL CONTROL OF
LARGEMOUTH BASS (LMB) ESTROGEN
RECEPTORS ALPHA, BETA-A AND BETAB BY METHOXYCHLOR (MXC) AND
ITS METABOLITES, MONO- AND BISHYDROXYMETHOXYCHLOR IN HEPG2
CELLS. J. L. Blum1, L. D. Stuchal2, M. O.
James2 and N. D. Desnlow3. 1Pharmacology and
Therapeutics, University of Florida, Gainesville,
FL, 2Medicinal Chemistry, University of Florida,
Gainesville, FL and 3Physiological Sciences,
#1936
DEVELOPMENT OF AN ENDOCRINE
DISRUPTOR BIOASSAY USING
INDUCTION OF VITELLOGENIN IN
CALIFORNIA HALIBUT (PARALYCHTHYS
CALIFORNICUS). A. Palumbo1, M. Koivunen2
and R. S. Tjeerdema1. 1Environmental Toxicology,
University of California, Davis, Davis, CA and
2
Entomology, University of California, Davis, Davis,
CA.
#1937
HERSHBERGER ASSAY: CODED AGONIST
AND ANTAGONIST STUDIES. E. L. Moore, L.
A. Waterson and S. Ruckman. Huntingdon Life
Sciences Ltd., Huntingdon, United Kingdom.
#1938
EFFECTS OF DI(N-BUTYL)PHTHALATE
ON GENE EXPRESSION OF THE MALE
REPRODUCTIVE ORGANS. T. Kang, H. Kang,
T. Kim, H. Moon, I. Kang, Y. Jun, E. Choi, I. Kim, S.
Han and J. Hong. KFDA/NITR, Seoul, South Korea.
#1939
CUMULATIVE EFFECTS OF IN UTERO
ADMINISTRATION OF A MIXTURE OF
SEVEN ANTIANDROGENS ON MALE RAT
REPRODUCTIVE DEVELOPMENT. L. E. Gray
and J. Furr. ORD, NHEERL, RTD, EB, U.S. EPA,
#1940
IN VITRO EVALUATION OF OCTAMETHY
LCYCLOTETRASILOXANE (D4) AND DEC
AMETHYLCYCLOPENTASILOXANE (D5)
AS PROGESTERONE RECEPTOR LIGAND.
K. P. Plotzke, P. A. Jean, J. A. Arthurton and S. D.
Crofoot. Dow Corning Corporation, Midland, MI.
#1941
2DPAGE AND ITRAQ LABELING:
COMPLEMENTARY TOOLS FOR IN-VIVO
ASSESSMENT/DIAGNOSIS OF AMPHIBIAN
THYROID AXIS-DISRUPTING CHEMICALS.
J. Serrano1, 2, B. Withuhn2, L. Higgings2, J. Korte1,
G. Holcombe1, P. Kosian1, J. Tietge1 and S. Degitz1.
1
NHEERL- MED. Duluth, U.S. EPA, Duluth,
MN and 2Biochemistry and Molecular Biology,
University of MN, St Paul, MN. Sponsor: J. Nichols.
POSTER SESSION: ENDOCRINE DISRUPTORS
Chairperson(s): Raphael Witorsch, Virginia Commonwealth University,
Richmond, VA and Xiaojuan Wang, CIIT Centers for Health Research,
#1928
#1929
#1930
#1931
#1932
#1933
NUCLEAR RECEPTOR COREGULATORS
AND ESTROGEN SENSITIVITY IN
REPRODUCTIVE ORGANS AND BRAIN
AFTER DEVELOPMENTAL EXPOSURE
TO AN ENDOCRINE DISRUPTER, 4METHYLBENZYLIDENE CAMPHOR. W.
Lichtensteiger, S. Durrer, C. Ehnes, M. Fuetsch,
M. Henseler, K. Maerkel and M. Schlumpf.
GREEN Toxicology, University of Zurich, Zurich,
Switzerland. Sponsor: R. Peterson.
ESTROUS CYCLICITY OF THE FISCHER 344
RAT FOLLOWING INHALATION EXPOSURE
WITH OCTAMETHYLCYCLOTETRASILOX
ANE (D4). A. L. Quinn, J. M. Regan, B. J. Marinik,
J. M. Tobin, S. D. Crofoot and K. P. Plotzke.
Corporation, Auburn, MI.
ESTROGENIC POTENCY OF MANY
POPULAR SUNCREENS AND LOTION
COMPONENTS DETECTED USING THE
LUMI-CELL® ER BIOASSAY. J. D. Gordon1,
A. C. Chu1, M. D. Chu2, C. Matherly1, M. S.
Denison3, G. Grune4 and G. C. Clark1. 1Xenobiotic
Detection Systems, Inc., Durham, NC, 2Analytical
Perspectives, Wilmington, NC, 3Department of
Davis, Davis, CA and 4ePatentmanager.com, VA
Beach, VA.
IDENTIFICATION OF CIRCADIAN RHYTHM
REGULATORS AS EARLY ESTROGENRESPONSIVE GENES IN THE IMMATURE
MOUSE UTERUS. J. G. Moggs, R. Stuckey, H.
Tinwell, D. Moore, F. Lim, I. Kimber, J. Ashby,
G. Orphanides and R. Currie. Syngenta CTL,
Macclesfield, Cheshire, United Kingdom.
NATURE OF BINDING INTERACTION
OF SELECTED CHEMICALS WITH RAT
ESTROGEN RECEPTORS. J. Eldridge1,
S. Yavanhxay1, R. Cooper2 and S. Laws2.
1
Physiol-Pharmacology, Wake Forest University
Winston-Salem, NC and 2Repro Toxicology
Division, NHEERL, U.S. EPA, Res Tri Park, NC.
ESTROGEN-MEDIATED GENE EXPRESSION
OF REDOX SENSITIVE CELL SIGNALING
PROTEINS. K. Triff, Q. Felty and D. Roy.
Environmental & Occupational Health, Florida
International University, Miami, FL.
215
WEDNESDAY
45th Annual
Meeting & ToxExpo
#1942
#1943
#1944
DEIODINASE TYPE I, II, AND III
EXPRESSION IN AMPHIBIAN PITUITARY,
THYROID, AND LIMB BUD AT KEY
STAGES OF DEVELOPMENT AND AFTER
EXPOSURE TO THE THYROID HORMONE
MODULATORS: METHIMAZOLE,
PERCHLORATE AND PROPYLTHIOURACIL.
J. J. Korte, H. M. Kerr, M. E. Bugge, L. M. Korte,
P. A. Kosian, G. W. Holcombe, J. E. Tietge and S. J.
Degitz. MED., NHEERL, ORD, U.S. EPA, Duluth,
MN. Sponsor: M. Hornung.
CONFIRMATION OF AMMONIUM
PERCHLORATE-INDUCED DIFFUSE
PATHOLOGIC HYPERPLASIA OF THYROID
FOLLICULAR EPITHELIUM IN THE RAT
USING ANTIBODY TO KI-67. J. R. Latendresse1,
L. Muskhelishvili1 and D. R. Doerge2. 1Toxicologic
Pathology Associates, Inc., Jefferson, AR and
2
Biochemical Toxicology, NCTR, Jefferson, AR.
ACTION AND TOXICITY OF VITAMIN D
ANALOGS ON BONE METABOLISM. C. I.
Nduaka1, C. Andresen2, E. Olson2, R. Pero2, R.
Lariviere2, N. Hanson2 and C. Bagi2. 1World Wide
Safety Sciences, Pfizer Inc., Groton, CT and
2
Comparative Physiology and Medicine, Pfizer Inc.,
Groton, CT.
WEDNESDAY
#1945
DIETHYLHEXYL PHTHALATE ALTERS
THE EXPRESSION OF STEROIDOGENIC
FACTOR-1 AND PPARγ IN FETAL RAT
TESTIS. A. Vinggaard1, J. Borch1, S. B. Metzdorff1,
L. Brokken2 and M. Dalgaard1. 1Department of
Toxicology and Risk Assessment, Danish Institute
for Food and Veterinary Research, Soborg, Denmark
and 2Department of Physiology, Institute of
Biomedicine, University of Turku, Turku, Finland.
Sponsor: E. Gray.
#1946
ATRAZINE STIMULATES THE RELEASE OF
ACTH AND ADRENAL STEROIDS IN MALE
WISTAR RATS. S. Laws, J. Ferrell, D. Best, A.
Buckalew, A. Murr and R. Cooper. RTD, NHEERL,
ORD, U.S. EPA, Research Triangle Park, NC.
#1947
CHLOROTRIAZINE-INDUCED
ALTERATIONS OF CELLULAR CALCIUM
SIGNALING AND LH RELEASE IN
ANTERIOR PITUITARY CELLS. T. A. Nichols,
W. H. Hanneman and R. B. Tjalkens. Department of
Environmental and Radiological Health, Colorado
State University, Fort Collins, CO.
#1948
POTENTIAL ROLE OF TUBEROINFUNDIBULAR DOPAMINERGIC NEURONS
IN THE DISRUPTION OF PITUITARY
HORMONE SECRETION BY ATRAZINE.
R. L. Cooper, A. Buckalew, S. Laws, A. Murr and
T. Stoker. EB, RTD, NHEERL, ORD, Research
Triangle Park, NC.
216
#1949
ASSESSMENT OF THE EFFECTS OF
CHEMICALS ON STEROIDOGENESIS
USING HUMAN H295R CELLS BY
SIMULTANEOUSLY MEASUREMENT OF A
DOZEN STEROID HORMONES. N. Terasaki,
M. Yamazaki, T. Hamano, Y. Ikeda and N. Tsutsui.
Toxicology Laboratory, Mitsubishi Pharma
Corporation, Chiba, Japan. Sponsor: J. Sugimoto.
#1950
MICROASSAY FOR THE DETECTION OF
GLUCOCORTICOID AGONIST/ANTAGONIST
ACTIVITY IN ENVIRONMENTAL
CHEMICALS. R. J. Witorsch, J. K. Taylor and
C. S. Jones. Physiology, Virginia Commonwealth
University, Richmond, VA.
#1951
CYTOCHROME P450 17 (CYP17), A
POTENTIAL TARGET FOR CANCER
CHEMOPREVENTION. M. B. van Duursen1,
R. Fernandez Canton1, P. van Binsbergen1, F. E.
Daamen1, S. Ruchirawat2 and M. van den Berg1.
1
Institute for Risk Assessment Sciences (IRAS),
Utrecht University, Utrecht, Netherlands and
2
Laboratory of Medicinal Chemistry, Chulabhorn
Research Institute, Bangkok, Thailand.
#1952
EFFECTS OF NEONATAL EXPOSURE TO
DIETHYLSTILBESTROL ON AQUAPORIN
GENE EXPRESSION LEVELS IN MOUSE
EPIDIDYMIS. Y. Yanagisawa1, K. Yamazaki1, C.
Mori1, 2, 3 and M. Komiyama1, 2, 3. 1Department of
Bioenvironmental Medicine, Graduate School
of Medicine, Chiba University, Chiba, Japan,
2
Environmental Health Science Project for Future
Generations, Graduate School of Medicine,
Chiba University, Chiba, Japan and 3Center for
Environment, Health and Field Sciences, Chiba
University, Kawasaki, Japan.
#1953
DEVELOPMENTAL TOXICITY OF
NITRATES: IS THERE A MECHANISTIC
LINK TO NITRIC OXIDE PRODUCTION?
B. S. Reeves and G. A. LeBlanc. Environmental
and Molecular Toxicology, North Carolina State
#1954
IDENTIFYING ADVERSE HEALTH IMPACTS
IN VULNERABLE POPULATIONS EXPOSED
TO CONTAMINANTS IN THE Universtiy of.S.
GREAT LAKES REGION: AN OVERVIEW.
H. Hicks, A. Ashizawa and C. De Rosa. ATSDR,
Atlanta, GA. Sponsor: B. Fowler.
45th Annual
Meeting & ToxExpo
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
#1962
DEMONSTRATION OF DIFFERENTIAL
TOXICITY INDUCED BY AMINOFLAVONE
PRODRUG IN HUMAN AND RAT PRECISION
CUT LUNG SLICES. H. Behrsing1, C. Ip2, T. Le2,
J. Tomaszewski3, C. Green2, C. Tyson2 and K. Amin2.
1
HepaHope, Inc., Irvine, CA, 2Biosciences Division,
SRI International, Menlo Park, CA and 3National
Cancer Institute, Rockville, MD.
#1963
HUMAN AND RAT LUNG TISSUE
EXHIBIT DIFFERENTIAL SENSITIVITY
TO PHORTRESS TOXICITY : USE OF
PRECISION-CUT LUNG SLICES. K. Amin1,
C. Ip1, T. Le1, J. Tomaszewski2, C. Green1, C. Tyson1
and H. Behrsing3. 1Biosciences Division, SRI
International, Menlo Park, CA, 2National Cancer
Institute, Rockville, MD and 3HepaHope Inc.,
Irvine, CA.
#1964
ASSESSMENT OF HUMAN
HEMATOPOIETIC PROGENITOR
PROLIFERATION IN A HIGH-THROUGHPUT
ASSAY. C. Pereira1, J. Damen1, A. Eaves1, 2 and E.
Clarke1. 1StemCell Technologies, Vancouver, BC,
Canada and 2Terry Fox Laboratory, Vancouver, BC,
Canada. Sponsor: R. MacFarland.
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS
Chairperson(s): Albert Li, Advanced Pharmaceutical Sciences, Columbia,
MD and Frank Barile, St. John’s University, Jamaica, NY.
#1955
NON INVASIVE IN VIVO IMAGING OF
HEPATOBILIARY STRUCTURE, FUNCTION
AND XENOBIOTIC RESPONSE IN A
TRANSPARENT FISH MODEL, THE SEETHROUGH MEDAKA (ORYZIAS LATIPES).
R. Hardman, D. Hinton and S. Kullman. Nicholas
School of the Environment and Earth Sciences,
Duke University, Durham, NC.
#1956
COMPARATIVE PROTEOMIC ANALYSIS OF
RAT LIVER BIOPSIES AND DERIVATIVE 3-D
LIVER CELL CULTURES. A. Wallington, W. M.
Purcell, J. T. Hancock, J. Hancock, J. Xu and N. D.
Avent. Faculty of Applied Sciences, University of
the West of England, Bristol, United Kingdom.
#1965
#1957
VALIDATION OF THE INTEGRATED
MULTIPLE ORGAN CO-CULTURE
(IDMOC) ASSAY FOR MULTIPLE ORGAN
CYTOTOXICITY. A. P. LI1, 2 and N. M. Li2.
1
Advanced Pharmaceutical Sciences, Columbia, MD
and 2In Vitro ADMET Laboratories, The ADMET
Group LLC, Rockville, MD.
IN VITRO TOXICITY OF LOWER IGNITION
PROPENSITY (LIP) AND CONVENTIONAL
CIGARETTES. G. Lulham1, J. Miller2, W. S.
Rickert3 and A. Trivedi3. 1JTI-Macdonald Corp.,
Toronto, ON, Canada, 2JT International SA, Geneva,
Switzerland and 3Labstat International, Kitchener,
ON, Canada.
#1966
FUNCTIONAL CHARACTERIZATION OF
A HUMAN RENAL EPITHELIAL CULTURE
MODEL. M. J. Powers1, S. Damian1, S. Hauber1,
P. Zeigler1, K. Mou2, J. Lee2, J. Li2 and I. J.
Hidalgo2. 1Cambrex Bio Science Walkersville, Inc.,
Walkersville, MD and 2Absorption Systems, LP,
Exton, PA.
#1967
CHARACTERIZATION OF A CYNOMOLGUS
MONKEY KIDNEY-DERIVED CELL LINE,
JTC-12, FOR SUITABILITY IN TOXICITY
EVALUATIONS. D. D. Baker, S. Sawant, M.
Cosenza, C. Afshari and R. Dunn. Amgen, Thousand
Oaks, CA.
#1968
REDUCING ANIMAL USE IN ACUTE
SYSTEMIC TOXICITY TESTING BY USING
IN VITRO CYTOTOXICITY ASSAYS FOR
ESTIMATING STARTING DOSES. J. A.
Strickland1, 2, M. W. Paris1, 2, S. Casati3, R. R. Tice2,
W. S. Stokes2, R. Lee4, E. Harvey4, J. Haseman5,
H. Raabe6, C. Cao7, R. Clothier8, G. Mun4, A.
Sizemore6, G. Moyer6, J. Madren-Whalley6, C.
Krishna7, M. Owen8, N. Bourne9, N. Wenk9 and M.
Vallant10. 1Integrated Laboratory Systems, Inc.,
Research Triangle Park, NC, 2NICEATM, NIEHS/
NIH/DHHS, Research Triangle Park, NC, 3ECVAM,
JRC, Ispra, Italy, 4Constella Group, Durham, NC,
5
Consultant, Raleigh, NC, 6IIVS, Gaithersburg, MD,
7
US Army ECBC, Aberdeen Proving Ground, MD,
8
University of Nottingham, Nottingham, United
Kingdom, 9BioReliance Corp., Rockville, MD and
10
NIEHS, NIEHS/NIH/DHHS, Research Triangle
Park, NC.
#1958
#1959
USE OF AN ADENOSINE TRIPHOSPHATE
CYTOTOXICITY (ATP) ASSAY IN NORMAL
HUMAN EPIDERMAL KERATINOCYTES TO
PREDICT SYSTEMIC TOXICITY IN VITRO.
E. Choi1, C. Danilo1, I. Rybina1, R. Samia1, H. A.
Raabe2, G. O. Moyer2 and J. W. Harbell2. 1Cambrex
Corporation, North Brunswick, NJ and 2Institute for
In Vitro Sciences, Inc., Gaithersburg, MD.
IN-2001 IS A NOVEL HISTONE
DEACETYLASE INHIBITOR WITH POTENT
ANTITUMOR ACTIVITY AGAINST BREAST
CANCER IN VITRO AND IN VIVO. K. N. Min,
K. E. Jeong, Y. W. Kim, K. Y. Kim, J. H. Kim, D.
Kim and Y. Y. Sheen. Pharmacy, Ewha Womans
University, Seoul, seoul, South Korea.
#1960
AUTOMATED MEASUREMENT OF
ANGIOGENIC TUBE FORMATION USING
A QUANTITATIVE, CELL-BASED IMAGING
ASSAY. R. N. Ghosh, L. E. Grove and O. Lapets.
Cellomics, Inc., Pittsburgh, PA. Sponsor: A.
Barchowsky.
#1961
A GLOBAL GENE EXPRESSION
COMPARISON OF MOUSE LUNG CELLS IN
VIVO AND IN VITRO. L. Berndt1, A. Williams2, P.
A. White1, J. Gingerich1, G. R. Douglas1 and C. L.
Yauk1. 1Mutagenesis Section, Safe Environments
Programme, Health Canada, Ottawa, ON, Canada
and 2Biostatistics and Epidemiology Division, Safe
Environments Programme, Health Canada, Ottawa,
ON, Canada.
217
WEDNESDAY
45th Annual
Meeting & ToxExpo
#1969
THE USE OF MOUSE FIBROBLAST (3T3)
AND NORMAL HUMAN EPIDERMAL
KERATINOCYES (NHK) CYTOTOXICITY
ASSAYS FOR ESTIMATING ACUTE ORAL
TOXICITY OF FORMULATIONS AND
MIXTURES. J. Charles1, J. Strickland1, M. Paris1,
R. Tice2 and W. Stokes2. 1Intergrated Laboratory
Systems, Inc., Research Triangle Park, NC and
2
NICEATM, NIEHS/NIH/DHHS, Research Triangle
Park, NC.
#1975
USE OF CRYOPRESERVED PRIMARY
NEURONAL CELLS FOR TOXICITY
SCREENING IN MULTIWELL CELL
CULTURE. A. Krantis1, 2, B. Tinner3, S.
VandenHoek3 and W. A. Staines1. 1Cellular&
Molecular Medicine, University Ottawa,
Ottawa, ON, Canada, 2Centre for Research in
Biopharmaceutics & Biotechnology, University
of Ottawa, Ottawa, ON, Canada and 3QBM Cell
Science, Ottawa, ON, Canada. Sponsor: M. Aschner.
#1970
REPRODUCIBILITY ANALYSES FOR IN
VITRO NEUTRAL RED UPTAKE METHODS
FROM A VALIDATION STUDY TO EVALUATE
IN VITRO CYTOTOXICITY ASSAYS FOR
ESTIMATING RODENT ACUTE SYSTEMIC
TOXICITY. M. Paris1, 2, J. Strickland1, 2, S. Casati3,
R. Tice2, W. Stokes2, H. Raabe4, C. Cao5, R. Clothier6,
J. Harbell4, G. Mun4, A. Sizemore4, G. O. Moyer4,
J. Madren-Whalley5, C. Krishna5, M. Owen6, N.
Bourne6, E. Harvey8, R. Lee8, J. Haseman7, P.
Crockett8, M. Wenk9 and M. Vallant10. 1Integrated
Laboratory Systems, Inc., Research Triangle Park,
NC, 2NICEATM, DHHS/NIH/NIEHS, Research
Triangle Park, NC, 3ECVAM, JRC, Ispra, Italy,
4
IIVS, Gaithersburg, MD, 5US Army ECBC,
Aberdeen Proving Ground, MD, 6University of
Nottingham, Nottingham, United Kingdom,
7
Private Consultant, Raleigh, NC, 8Constella Group,
Durham, NC, 9BioReliance Corp., Rockville, MD
and 10NIEHS, DHHS/NIH, Research Triangle Park,
NC.
#1976
FURTHER VALIDATION OF AN IN VITRO
NEUROTOXICITY DATABASE. A. D. Weissman.
NovaScreen Biosciences, Caliper Life Sciences,
Hanover, MD.
#1971
#1972
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: FOOD SAFETY AND NUTRITION
Chairperson(s): Jay Vodela, U.S. Department of Agriculture, Washington,
DC and Roger A. Coulombe, Jr., Utah State University, Logan, UT.
AN INTEGRATED TESTING APPROACH
FOR THE SAFETY EVALUATION OF NEW
AND EXISTING CHEMICALS. I. Gubbels1, B.
Blaauboer2, I. Meerts1, H. Barentsen1, M. Hoitink1
and J. v.d. Hoeven1. 1Regulatory Affairs, NOTOX
B.V., ‘s-Hertrogenbosch, Netherlands and 2Institute
for Risk Assessment Sciences, Utrecht University,
Utrecht, Netherlands.
EFFECT OF SUBACUTE DAILY REPEATED
EXPOSURE TO 18 CHEMICALS ON
CULTURED IMMORTAL HUMAN
INTESTINAL EPITHELIAL CELL viaBILITY.
S. J. Pai and F. A. Barile. Pharmaceutical Sciences,
St. John’s University College of Pharmacy, Jamaica,
NY.
WEDNESDAY
#1973
CORRELATION OF IN VITRO
CYTOTOXICITY WITH PARACELLULAR
PERMEABILITY IN MORTAL RAT
INTESTINAL CELLS. R. Konsoula and F.
A. Barile. Pharmaceutical Sciences, St. John’s
University College of Pharmacy, Jamaica, NY.
#1974
EFFECT OF TRACE METALS ON β-ACTIN
EXPRESSION AND NEWLY SYNTHESIZED
PROTEINS IN CULTURED HUMAN
INTESTINAL EPITHELIAL CELLS. A. R.
Calabro and F. A. Barile. Pharmaceutical Sciences,
St. John’s University College of Pharmacy, Jamaica,
NY.
218
#1977
TOXICITY RISK ASSESSMENT OF CARICA
PAPAYA LEAVES AQUEOUS EXTRACT IN
ALBINO RATS (RATTUS NOVEGICUS). E.
B. Tungla1 and H. M. Lantum2. 1Department of
Biochemistry, University of Yaounde I, Yaounde,
Cameroon and 2African Society for Toxicological
Sciences (ASTS), Rochester, NY.
#1978
CHEMOPROTECTIVE POTENTIAL OF
NARINGENIN, A NATURALLY OCCURRING
CITRUS FLAVANONE, IN DOXORUBICIN
INDUCED CLASTOGENICITY. S. M. Nataraj,
R. Reddy, E. Kannan and S. Bhojraj. Pharmacology
and Toxicology, J.S.S. College of Pharmacy,
Ootacamund, Tamilnadu, India. Sponsor: P. Bommu.
#1979
LONG-TERM EXPOSURE EFFECTS
OF A NOVEL PHYTOCHEMICALNUTRACEUTICAL MIXTURE (METABOLIC
NUTRITION SYSTEM-PLATINUM)
ON SERUM BIOCHEMISTRY AND
HISTOPATHOLOGY OF SEVEN VITAL
TARGET ORGANS OF B6C3F1 MICE.
S. D. Ray1, S. Patel1, J. Rathod1, N. Patel1, E.
Bulku1, D. Zinkovsky1, R. M. Hackman2 and S. J.
Stohs3. 1Divi. of Pharmacology Scs., Long Island
University, Brooklyn, NY, 2Department of Nutrition,
University of California, Davis, CA and 3AdvoCare
International, Carrolton, TX.
#1980
SAFETY EVALUATION OF AN ALPHA
AMYLASE (EBS-2) PRODUCED FROM
BACILLUS LICHENIFORMIS. Q. Q. Bui1,
C. N. Edwards2 and A. Christensen2. 1Genencor
International Inc., Palo Alto, CA and 2Scantox A/S,
Lille Skensved, Denmark.
45th Annual
Meeting & ToxExpo
#1981
SUBACUTE ORAL TOXICITY OF PHASE
2 STARCH NEUTRALIZER™ (PHASE 2®),
A STANDARDIZED WHITE KIDNEY BEAN
(PHASEOLUS VULGARIS) EXTRACT IN RATS.
D. H. Bechtel1, K. Vega1 and M. Skop2. 1CANTOX
U.S. Inc., Bridgewater, NJ and 2Pharmachem
Laboratories, Inc., Kearny, NJ.
#1988
DOCOSAHEXAENOIC ACID DEFICIENCY
AND SUPPLEMENTATION DISTINCTLY
ALTER HEPATIC mRNA EXPRESSION OF
UPTAKE AND EFFLUX TRANSPORTERS
IN RATS. H. Lu, M. Ozias, X. Lei, B. Levant and
C. Klaassen. Pharmacology and Toxicology, KU
#1982
CHRONIC TOXICITY EVALUATION OF
A CHARACTERIZED SOY ISOFLAVONE
MIXTURE IN RATS. W. D. Johnson1, T. L. Horn1,
R. L. Morrissey2, I. M. Kapetanovic3, J. A. Crowell3
and D. L. McCormick1. 1IIT Research Institute,
Chicago, IL, 2Pathology Associates, Chicago, IL and
3
#1989
#1983
CHRONIC TOXICITY EVALUATION OF
A CHARACTERIZED SOY ISOFLAVONE
MIXTURE IN DOGS. J. Harder1, W. D. Johnson1,
R. L. Morrissey2, I. M. Kapetanovic3, J. A. Crowell3
and D. L. McCormick1. 1IIT Research Institute,
Chicago, IL, 2Pathology Associates, Chicago, IL and
3
N-3 PUFA DOCOSAHEXAENOIC ACID
INHIBITION OF DEOXYNVALENOLINDUCED CREB PHOSPHORYLATION
CORRELATES WITH DECREASED
UPSTREAM AKT1 KINASE ACTIVITY. Y. Shi1,
2
and J. J. Pestka1, 2, 3. 1Food Science and Human
Nutrition, Michigan State University, East Lansing,
MI, 2Food Science and Human Nutrition, Michigan
State University, East Lansing, MI and 3Center for
East Lansing, MI.
#1990
DOCOSAHEXAENOIC ACID CONSUMPTION
MODULATES HOST RESPONSE TO
ENTERIC REOVIRUS INFECTION IN THE
MOUSE. E. Beli1, M. Li1, 3, 2, C. Cuff4 and J. Pestka1,
3, 2 1
. Food Science and Human Nutrition, Michigan
State University, East Lansing, MI, 2Department of
Microbiology and Molecular Genetics, Michigan
State University, East Lansing, MI, 3Center for
East Lansing, MI and 4Department of Microbiology
and Immunology, West Virginia University,
Morgantown, WV.
#1991
BUTYLATED HYDROXYTOLUENE
CHEMOPREVENTION OF AFLATOXICOSIS
IN TURKEYS IS DOSE-RELATED. J. A.
Guarisco, J. O. Hall and R. A. Coulombe. Graduate
Toxicology Program and Department of Veterinary
Sciences, Utah State University, Logan, UT.
#1992
INDUCTION OF NEURAL TUBE DEFECTS
IN CD1 MICE BY INTRAPERITONEAL
EXPOSURE TO FUMONISIN B1 T. D. Burns1,
2
, R. T. Riley2, J. B. Gelineau-van Waes3 and K. A.
Voss2. 1Pharmaceutical and Biomedical Sciences,
University of Georgia, Athens, GA, 2Toxicology and
Mycotoxin Research, USDA-ARS, Athens, GA and
3
Genetics, Cell Biology and Anatomy, University of
Nebraska Medical Center, Omaha, NE.
#1993
EVIDENCE FOR INCREASED SPHINGOID
BASE 1-PHOSPHATE LYASE ACTIVITY IN
CORN SEEDLINGS AFTER PROLONGED
EXPOSURE TO FUMONISIN. L. D. Williams1,
2
, A. E. Glenn2, C. W. Bacon2, M. A. Smith1 and
R. T. Riley2, 1. 1Environmental Health Sciences,
University of Georgia, Athens, GA and 2Toxicology
and Mycotoxin Research Unit, USDA-ARS, Athens,
GA.
#1994
RNAI – MECHANISMS AND TOOLS FOR
TOXIN CONTROL IN ASPERGILLUS
SPECIES. E. A. Bolterstein1 and N. P. Keller2, 1.
1
METC, University of Wisconsin, Madison, WI and
2
Plant Pathology, University of Wisconsin, Madison,
WI. Sponsor: J. Johnson.
#1984
#1985
#1986
#1987
EFFECTS OF SYNEPHRINE AND
CAFFEINE ON PHYSIOLOGICAL AND
CARDIOVASCULAR VARIABLES IN FEMALE
SPRAGUE-DAWLEY RATS. P. Duffy1, G. White1,
K. Wall1, S. Appana1, L. Pellicore2 and D. Hansen1.
1
Division of Genetic and Reproductive Toxicology,
National Center for Toxicological Research,
Jefferson, AR and 2Division of Dietary Supplement
Programs and Compliance, Center for Food Safety
and Applied Nutrition, College Park, MD. Sponsor:
M. Moore.
EFFECT OF PHYLLANTHUS
MADERASPATENSIS, A DIETARY
SUPPLEMENT ON CISPLATIN INDUCED
CLASTOGENICITY IN CULTURED HUMAN
LYMPHOCYTES. P. Bommu, M. Nanjan, M.
Chandrasekar and B. Suresh. TIFAC CORE
in Herbal Drugs, J.S.S College of Pharmacy,
Ootacamund, Tamilnadu, India.
THE ANTHOCYANIDIN DELPHINIDIN
ACTS AS A CATALYTIC TOPOISOMERASE
I AND II INHIBITOR, SUPPRESSING
THE DNA-DAMAGING PROPERTIES OF
TOPOISOMERASE POISONS IN-VITRO. D.
Marko and J. Fritz. Institute of Applied Biosciences,
University of Karlsruhe, Karlsruhe, Germany.
Sponsor: M. Metzler.
THE COMBINED EFFECT OF ISOFLAVONE
AND E2 ON VAGINAL OPENING OF FEMALE
MICE. K. Takashima-Sasaki1, 2, H. Fukata1, 2, C.
Mori1, 2 and M. Komiyama1, 2, 3. 1Bioenvironmental
Medecine, Graduate School of Medicine, Chiba
University, Chiba, Japan, 2Environmental Health
Science Project for Future Generations, Graduate
School of Medicine, Chiba University, Chiba, Japan
and 3Center for Environment, Health and Field
Sciences, Chiba University, Kashiwa, Japan.
219
WEDNESDAY
45th Annual
Meeting & ToxExpo
#1995
#1996
LEAD AND CADMIUM EXPOSURES FROM
CANNED AND NON-CANNED BEVERAGES
IN NIGERIA: A PUBLIC HEALTH CONCERN.
O. E. Orisakwe2 and J. M. Maduabuchi2. 1Health and
Environmental Laboratories, Eastman Kodak Co.,
Rochester, NY and 2Toxicology Unit, Department of
Pharmacology, Nnamdi Azikiwe University, Nnewi,
Nigeria. Sponsor: H. Lantum.
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
INHIBITORY EFFECTS OF ANTIOXIDANTS
AND PHASE II-ENZYME INDUCERS ON
ACRYLAMIDE-INDUCED RAT MAMMARY
CARCINOGENESIS. T. Imai, S. Takami, Y. Cho,
M. Hasumura and M. Hirose. National Institute of
Health Sciences, Tokyo, Japan. Sponsor: M. Ema.
#1997
THE FLAVORING AGENT
DIHYDROCOUMARIN IS AN EPIGENETIC
TOXICANT THAT INHIBITS SIRTUIN
DEACETYLASES. A. J. Olaharski1, J. Rine2, B.
Marshall3, J. Babiarz2, L. Zhang1, E. Verdin3 and M.
T. Smith1. 1School of Public Health, UC Berkeley,
Berkeley, CA, 2MCB, UC Berkeley, Berkeley, CA
and 3Gladstone Institute, UCSF, San Francisco, CA.
#1998
ASSESSMENT OF THE RISKS AND
BENEFITS OF A METHYLMERCURYCONTAMINATED SEAFOOD DIET
USING AN INTEGRATED FUNCTIONAL
TOXICOGENOMIC APPROACH IN A
MAMMALIAN MODEL. C. Glover1, C.
Hogstrand2, D. Zheng2, G. Sales2 and A. Lundebye1.
1
NIFES, Bergen, Norway and 2King’s College
London, London, United Kingdom. Sponsor: D. St.
Clair.
#1999
#2000
#2001
POSTER SESSION: CELL DEATH/APOPTOSIS
Chairperson(s): Anumantha Kanthasamy, Iowa State University, Ames, IA
and John Richburg, University of Texas at Austin, Austin, TX.
FAST IDENTIFICATION OF FIFTEEN FOODMEAT SPECIES BY ELECTROCHEMICAL
LIQUID CHROMATOGRAPHIC PROFILING.
C. Chou1, J. A. Lin1, K. Tung1, C. Mao1 and J.
Zen2. 1Veterinary Medicine, National Chung-Hsing
University, Taichung, Taiwan and 2Chemistry,
National Chung Hsing University, Taichung, Taiwan.
THE NATIONAL RESIDUE PROGRAM
(NRP)AS A FOOD SAFETY TOOL. J. Vodela1,
P. Zervos1, C. Deyrup1, R. Sutton1, M. O’Keefe1, D.
Pagan1 and H. Walker1. 1Residue Branch, USDA/
FSIS, Washington DC, DC, 2USDA, Washington
DC, DC, 3USDA, Washington DC, DC, 4USDA,
Washington DC, DC, 5USDA, Washington DC, DC,
6
USDA, Washington DC, DC, 7USDA, Washington
DC, DC and 8USDA, Washington DC, DC.
HEALTH HAZARD ASSESSMENT FOR EGG
ALLERGY. S. Assimon and P. M. Bolger. CFSAN,
USFDA, College Park, MD.
WEDNESDAY
220
#2002
MITOCHONDRIAL TARGETING OF
HEMIGRAMICIDIN S-PEPTIDYLNITROXIDES PROTECTS AGAINST
CARDIOLIPIN OXIDATION AND APOPTOSIS
IN MOUSE EMBRYONIC CELLS. J. Jiang1, N.
A. Belikova1, V. A. Tyurin1, Q. Zhao1, J. Xiao2, M.
P. Fink3, P. Wipf2 and V. E. Kagan1. 1Center for Free
Radical and Antioxidant Health, Department of
of Pittsburgh, Pittsburgh, PA, 2Department of
Chemistry, University of Pittsburgh, Pittsburgh,
PA and 3Department of Critical Care Medicine,
#2003
LYSOCARDIOLIPINS IN APOPTOSIOS:
INTERACTIONS WITH CYTOCHROME C,
TBID AND ASYMMETRY OF DISTRIBITION
IN MITOCHONDRIA. V. A. Tyurin1, A. N.
Osipov1, Y. Y. Tyurina1, H. Bayir1, L. V. Basova1, N.
A. Belikova1, A. A. Kapralov1, Q. Zhao1, J. Jiang1,
P. K. Gill2, D. H. Waldeck2 and V. E. Kagan1.
1
EOH, Center for Free Radical and Antioxidant
Health University of Pittsburgh, Pittsburgh, PA and
2
Chemistry, University of Pittsburgh, Pittsburgh, PA.
#2004
PEROXIDASE ACTIVITY AND UNFOLDING
OF CYTOCHROME C INDUCED BY
CARDIOLIPIN: ROLE IN APOPTOTIC
SUGNALING. N. A. Belikova, Y. A. Vladimirov,
A. N. Osipov, A. A. Kapralov, L. V. Basova, I. V.
Kurnikov and V. E. Kagan. Center for Free Radical
and Antioxidant Health, University of Pittsburgh,
Pittsburgh, PA.
#2005
A NEW BIOMARKER OF EARLY APOPTOSIS
IN THE BRAIN: CARDIOLIPIN OXIDATION.
H. Bayir3, 2, V. Tyurin1, Y. Tyurina1, J. Jiang1, V.
Ritov1, X. Zhang1, Q. Zhao1, P. Kochanek3, R. Clark3,
S. DeKosky2 and V. Kagan1. 1Ctr for Free Radical &
Antioxidant Health, Env Occup Health, Universtiy
of Pitt, Pgh, PA, 2Neurology, Universtiy of Pitt, Pgh,
PA and 3Crit Care Med., Universtiy of Pitt, Pgh, PA.
#2006
LOW CONCENTRATION OF DOMOIC
ACID (DA) INDUCES MITOCHONDRIALLY
MEDIATED APOPTOTIC DEATH IN MOUSE
CEREBELLAR GRANULE CELLS. G.
Giordano1, C. White1, T. Kavanagh1 and L. Costa1, 2.
1
University of Washington, Seattle, WA and 2Human
Anatomy, Pharmacology and Forensic Medicine,
University of Parma Medical School, Parma, Italy.
45th Annual
Meeting & ToxExpo
LENTIVIRAL MEDIATED EXPRESSION
OF THE CATALYTIC FRAGMENT OF
PKC DELTA IN THE SUBSTANTIA
NIGRA PROMOTES DOPAMINERGIC
DEGENERATION: EVIDENCE FOR
PROAPOPTOTIC FUNCTION OF THE
OXIDATIVE STRESS SENSITIVE KINASE
PKC DELTA IN PARKINSON’S DISEASE. H.
Saminathan, Y. Yang, D. Zhang, V. Ananthram, A.
Kanthasamy and A. G. Kanthasamy. Department of
Biomedical Sciences, Iowa State University, Ames,
IA.
#2014
Z-VAD-FMK AND Z-FA-FMK RESCUE RAT
PLEURAL MESOTHELIAL CELL FROM
CADMIUM CHLORIDE INDUCE APOPTOSIS.
K. Mirchandani and J. M. Cerreta. PHS, St. John’s
University College of Pharmacy and Allied Health
Professions, Jamaica, NY. Sponsor: L. Trombetta.
#2015
CADMIUM INDUCES APOPTOSIS IN HUMAN
OSTEOSARCOMA CELLS. K. G. Coonse, A. J.
Coonts, E. V. Morrison and S. J. Heggland. Biology,
Albertson College of Idaho, Caldwell, ID. Sponsor:
V. Garry.
#2008
PROTEASOME INHIBITOR-INDUCED
APOPTOSIS IN DOPAMINERGIC NEURONAL
CELLS IS MEDIATED BY A FEEDBACK
AMPLIFICATION OF MITOCHONDRIAL
CASPASE CASCADE BY PKC DELTA. F. Sun,
V. Anantharam, Y. Yang, A. Kanthasamy and A. G.
Kanthasamy. Iowa State Universuty, Ames, IA.
#2016
THE DEVELOPMENT OF AN IN VITRO
MODEL FOR THE DETECTION AND
EVALUATION OF DRUG-INDUCED
MYOPATHY. S. Boldt1, E. Wu2, S. Schomaker1, G.
Boucher1, A. Jakowski1, R. Valdez1 and D. Amacher1.
1
WWSS, Pfizer, Inc., Groton, CT and 2Pharmacy,
Rutgers State University, Princeton, NJ.
#2009
ROLE OF CASPASE-2 IN ETOPOSIDERESISTANT APAF1 KNOCKDOWN JURKAT
T-CELLS. P. Bu, E. E. Franklin and J. D. Robertson.
Pharmacology, Toxicology and Therapeutics, MS
1018, University of Kansas Medical Center, Kansas
City, KS.
#2017
CHEMICALLY-INDUCED APOPTOSIS
IN FRESHLY-ISOLATED HUMAN
HEPATOCYTES. D. Amacher2, G. Chen1 and P.
Silber1. 1In Vitro Technologies, Inc., Baltimore, MD
and 2Pfizer, Groton, CT.
#2018
#2010
DMBA-INDUCED APOPTOSIS OF BONE
MARROW B CELLS IS LIKELY INITIATED
THROUGH A METABOLITE-DRIVEN,
MITOCHONDRIAL PATHWAY. J. K. Emberley1,
J. J. Schlezinger2, H. Ryu2 and D. H. Sherr2.
1
Microbiology, Boston University School of
Medicine, Boston, MA and 2Environmental Health,
Boston University School of Public Health, Boston,
MA.
INVOLVEMENT OF NUR77 AND CELL
SIGNALING PATHWAYS IN TRIBUTYLTININDUCED APOPTOSIS IN MOUSE
TESTICULAR CELLS. K. Lee3, 1 and H. Jeong1,
2 1
. Pharmacy, Chosun University, Kwangju, South
Korea, 2Research Center for Proteineous Materials,
3
Laboratory of Cell Biology, NHLBI, NIH,
Bethesda, MD.
#2019
#2011
IDENTIFICATION OF MITOCHONDRIAL
PROTEIN TARGETS OF APOPTOSISINDUCING ELECTROPHILES. H. L. Wong and
D. C. Liebler. Biochemistry, Vanderbilt University,
Nashville, TN.
#2012
MITOCHONDRIA MEDIATED APOPTOSIS
AND CELL CYCLE ARREST IN RAW264.7
CELLS WERE INDUCED BY THE
CYTOSTATIC COMPOUND PRODUCED
DURING CO-CULTIVATION OF TWO
INDOOR AIR MICROBES. P. Penttinen1, 2,
J. Pelkonen2, 3, K. Huttunen1 and M. Hirvonen1.
1
Department of Environmental Health, National
Public Health institute, Kuopio, Finland, 2University
of Kuopio, Kuopio, Finland and 3Kuopio University
Hospital, Kuopio, Finland. Sponsor: M. Viluksela.
ACTIVATION OF P53 IN TESTICULAR
SPERMATOCYTES CONTRIBUTES TO
THEIR SENSITIVITY TO UNDERGO FASMEDIATED APOPTOSIS. C. M. McKee1 and J.
H. Richburg2. 1Cell and Molecular Biology Graduate
Program, The University of Texas at Austin, Austin,
TX and 2College of Pharmacy, The University of
Texas at Austin, Austin, TX.
#2020
CHARACTERIZATION OF TRAIL-INDUCED
TESTICULAR GERM CELL APOPTOSIS. J.
H. Richburg and Y. Ye. College of Pharmacy, The
University of Texas at Austin, Austin, TX.
#2021
THE EFFECT OF POST MORTEM DELAY ON
MARKERS OF APOPTOSIS IN THE RAT. C.
Scudamore and A. Scott. Covance Laboratories Ltd.,
Harrogate, United Kingdom. Sponsor: D. Everett.
#2013
AEROSOL DELIVERY OF GLUCOSYLATED
POLYTHEYLENIMINE/PROGRAMMED
CELL DEATH 4 (PDCD4) COMPLEX
REGULATED APOPTOSIS, CELL CYCLE
AN IN LUNGS OF AP-1 LUCIFERASE MICE.
S. Hwang and M. Cho. Laboratory of Toxicology,
College of Veterinary Medicine, Seoul National
WEDNESDAY
#2007
221
45th Annual
Meeting & ToxExpo
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
#2028
GLUTATHIONE (GSH) HOMEOSTASIS
AND CADMIUM-INDUCED CELL INJURY
IN RAT LUNG FIBROBLASTS. D. Chou1, X.
Du1, W. Li2, Y. Zhao2 and I. Chou1. 1Microbiology,
Boston University School of Medicine, Boston, MA
and 2Biochemistry, Boston University School of
Medicine, Boston, MA.
#2029
CHARACTERIZATION OF TRANSPORT
PROPERTIES AND SUBCELLULAR
LOCALIZATION OF ZIP8, AN IMPORTANT
ROGUE TRANSPORTER OF CADMIUM. J.
M. Reed, L. He, S. Girigashanker, T. P. Dalton and
D. W. Nebert. Environmental Health, University of
Cincinnati Medical Center, Cincinnati, OH.
#2030
BACTERIAL ARTIFICIAL CHROMOSOME
(BAC) TRANSGENESIS CONFIRMS THAT
Slc39a8 IS THE Cdm GENE CONFERRING
SENSITIVITY TO CADMIUM. B. Wang, T. P.
Dalton, L. He and D. W. Nebert. Environmental
Health, University of Cincinnati Medical Center,
Cincinnati, OH.
#2031
ACUTE EXPOSURE TO CADMIUM INDUCES
PRODUCTION OF GRANULOCYTE
COLONY-STIMULATING FACTOR ALONG
WITH NEUTROPHILIA IN MICE. H.
Horiguchi, E. Oguma, H. Uno and F. Kayama.
Division of Environmental Medicine, Center for
Community Medicine, Jichi Medical School,
Tochigi, Japan. Sponsor: T. Yoshida.
#2032
INHIBITORY EFFECT OF THIONEIN
ON RIBONUCLEASE A ACTIVITY. E. M.
Brambila1, K. Rubin1, B. Leon-Chavez1 and W. E.
Achanzar2. 1Labortorio de Investigaciones Quimico
Clinicas, University of Puebla, Puebla, Mexico and
2
Toxicology, Bristol-Myers Squibb Pharmaceutical
Research Institute, New Brunswick, NJ.
#2033
THE RWPE-1 CELL LINE AS A MODEL
SYSTEM FOR PROSTATE EPITHELIUM. R.
K. Singh, S. Somji, X. Zhou, A. Albrecht, M. Sens,
D. A. Sens and S. H. Garrett. Pathology, University
of North Dakota, Grand Forks, ND.
#2034
HIF1α -/- MOUSE EMBRYONIC
FIBROBLAST CELLS SHOW INCREASED
SUSCEPTIBILITY TO CADMIUM-INDUCED
TOXICITY. A. Vengellur2 and J. LaPres1, 3.
1
Biochemistry, Michigan State University, East
Lansing, MI, 2Graduate Program in Genetics,
3
National Food Safety and Toxicology Center,
#2035
INTRACELLULAR SIGNALLING MAPKS
PATHWAYS IN CDCL2 TREATED HEPG2
CELLS. C. Escobar, V. Souza, E. Hernandez, L.
E. Gómez-Quiroz, L. Bucio and M. GutierrezRuiz. Health Science, Universidad Autonoma
Meropolitana, Mexico, D.F., Mexico.
POSTER SESSION: CD TOXICITY, ZINC, AND
METALLOTHIONEIN
Chairperson(s): Michael Waalkes, NIEHS, Research Triangle Park, NC
and Scott Garrett, University of North Dakota, Grand Forks, ND.
#2022
CADMIUM-INDUCED DISRUPTION OF
PROXIMAL TUBULE CELL ADHESION IS
ASSOCIATED WITH REDISTRIBUTION OF
CELL ADHESION MOLECULES AND LOSS
OF EPITHELIAL POLARITY. J. Edwards1, P. C.
Lamar1, E. Diamantakos1, J. D. Peuler1, J. Liu2, M.
P. Waalkes2 and W. C. Prozialeck1. 1Pharmacology,
Midwestern University, Downers Grove, IL and
2
National Cancer Institute, NIEHS, Research
Triangle Park, NC.
#2023
GENE EXPRESSION PROFILES
OF CADMIUM-RESISTANT
METALLOTHIONEIN NULL CELLS. H.
Fujishiro1, M. Satoh2 and S. Himeno1. 1Fac. of
Pharmaceutical Sciences, Tokushima Bunri
University, Tokushima, Japan and 2Department of
Hygienics, Gifu Pharmaceutical University, Gifu,
Japan.
#2024
Slc39a8 GENE OVEREXPRESSION
SENSITIZES MICE TO CADMIUM-INDUCED
RENAL DYSFUNCTION. S. N. Schneider,
B. Wang, L. He, T. P. Dalton and D. W. Nebert.
#2025
PRONOUNCED INTERACTION BETWEEN
CADMIUM AND ZINC ON TESTICULAR
PROSTAGLANDIN F2ALPHA (PGF2) LEVELS
– MECHANISM RELATED TO EFFECTS OF
CADMIUM ON REPRODUCTIVE TISSUES.
G. F. Nordberg1, D. Gunnarsson2, M. Svensson1
and G. Selstam2. 1Environmental medicine, Umea
University, Umea, Sweden and 2Molecular Biology,
Umea University, Umea, Sweden.
WEDNESDAY
#2026
GENOMIC ANALYSIS OF
HEPATOPROTECTIVE ZINC EXPOSURE IN
MICE AND RATS. J. Liu1, J. Boos1, W. Zhang2
Triangle Park, NC and 2LPC, NIEHS, Research
Triangle Park, NC.
#2027
APOPTOTIC RESISTANCE IN CADMIUMTRANSFORMED HUMAN PROSTATE
EPITHELIAL CELLS. W. Qu1, H. Ke2, D.
Broderick1, J. E. French2, M. M. Webber3 and M. P.
Waalkes1. 1LCC, NCI at NIEHS, Research Triangle
Park, NC, 2NIEHS, Research Triangle Park, NC and
3
222
45th Annual
Meeting & ToxExpo
#2037
MICROARRAY ANALYSIS OF CADMIUM
RESPONSIVE TRANSCRIPTION IN
CAENORHABDITIS ELEGANS. Y. Cui1, W.
A. Boyd2, S. J. McBride1 and J. H. Freedman1, 2.
1
Nicholas School of the Environment and Earth
Sciences, Duke University, Durham, NC and
2
Laboratory of Molecular Toxicology, ETP, DIR,
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
SELECTIVE OVER-EXPRESSION
OF DNMT3B IS SUFFICIENT FOR
GLOBAL AND GENE SPECIFIC DNA
HYPERMETHYLATION DURING CADMIUMINDUCED MALIGNANT TRANSFORMATION.
L. Benbrahim-Tallaa1, J. Coppin1, M. M. Webber2
Triangle Park, NC and 2Michigan State University,
East Lansing, MI.
POSTER SESSION: METALS TOXICOLOGY II
Chairperson(s): Steve Roberts, University of Florida, Gainesville, FL and
Iih-Nan Chou, Boston University, Boston, MA.
#2038
THE UNIQUE N-TERMINAL SEQUENCE OF
MT-3 IS REQUIRED FOR THE APOPTOTIC
TO NECROTIC SHIFT IN RESPONSE TO
CADMIUM IN MT-3 TRANSFECTED CELLS.
D. A. Sens, S. Somji, M. Sens and S. H. Garrett.
Pathology, University of North Dakota, Grand Forks,
ND.
#2039
EXPRESSION OF METALLOTHIONEINS IN
HUMAN PROSTATE TUMORS: EVIDENCE
OF POST-TRANSCRIPTIONAL CONTROL.
S. H. Garrett, R. K. Singh, X. Zhou, M. Sens, S.
Somji and D. A. Sens. Pathology, University of North
Dakota, Grand Forks, ND.
#2040
STUDIES ON BLOOD METALLOTHIONEIN
AS A BIOMARKER OF TISSUE
METALLOTHIONEIN EXPRESSION. J. Shen,
J. Liu and M. P. Waalkes. LCC, NCI at NIEHS,
#2041
DOWN REGULATION OF MT-3 EXPRESSION
IN HUMAN PROXIMAL TUBULE CELLS
DECREASES DOME FORMATION AND
ATTENUATES APOPTOSIS. S. Somji, S.
H. Garrett, M. Sens and D. A. Sens. Pathology,
University of North Dakota, Grand Forks, ND.
#2042
OVER EXPRESSION OF
METALLOTHIONEIN IN HUMAN BLADDER
CANCER IS CORRELATED TO POOR
PROGNOSIS. X. Zhou, M. Sens, S. Somji, S. H.
Garrett and D. A. Sens. Pathology, University of
North Dakota, Grand Forks, ND.
223
#2043
BEHAVIOR OF BISMUTH ADMINISTERED
INTRATRACHEALLY TO RATS. A. Shinohara1,
M. Chiba1, H. Sato2, K. Omae3, M. Okamoto4,
K. Serizawa4 and Y. Inaba1. 1Department of
Epidemiology and Environmental Health, Juntendo
University School of Medicine, Tokyo, Japan,
2
Environmetal Health Science, Tohoku University
Graduate School of Medicine, Sendai, Japan,
3
Department of Preventive Medicine and Public
Health, Keio University, School of medicine,
Tokyo, Japan and 4Production Engineering Research
Laboratory, Hitachi Ltd., Yokohama, Japan.
#2044
UBIQUITINATION AND DEGRADATION OF
EUKARYOTIC TRANSLATION INITIATION
FACTOR 4E RESULT IN TOXICITY AND
DEATH IN HELA CELLS EXPOSED TO
POTASSIUM DICHROMATE. S. Othumpangat
and P. Joseph. Health Effects Laboratory Division,
NIOSH, Morgantown, WV.
#2045
ALPHA-TOCOPHEROL PREVENTS
CHANGES ON THE CLAUDIN-2
AND OCCLUDIN EXPRESSION AND
LOCALIZATION PATTERN, INDUCED BY
POTASSIUM DICHROMATE IN MURINE
KIDNEY. L. Arreola-Mendoza1, J. L. Reyes2, M. E.
Mendoza-Garrido2, D. Martin2, M. C. Namorado2,
E. I. Sanchez2, B. Reyes2 and L. M. Del Razo1.
1
Toxicology, Cinvestav, Mexico D.F., Mexico and
2
Physiology & Biophysics, Cinvestav, Mexico D.F.,
Mexico.
#2046
CHROMIUM (VI) INDUCES ANTIOXIDANT
GENE HO-1 BY ACTIVATING THE CNC BZIP
TRANSCRIPTION FACTOR NRF2. X. He1,
G. Lin1, J. Zhang2 and Q. Ma1. 1Receptor Biology
Laboratory/TMBB, NIOSH, Morgantown, WV and
2
Harvard University, Boston, MA.
#2047
CHROMIUM(VI) REQUIRES HISTONE
DEACETYLASE TO INDUCE INTERFERONSTIMULATED GENES. A. A. Nemec, K.
A. O’Hara, L. R. Klei, R. J. Vaghjiani and A.
Barchowsky. Environmental and Occupational
Health, University of Pittsburgh, Pittsburgh, PA.
#2048
COMET ASSAY ANALYSIS OF DNA DAMAGE
INDUCED BY CHROMIUM PICOLINATE.
A. Lencinas, C. S. Asplund, V. H. Coryell and D.
M. Stearns. Department of Chemistry, Northern
Arizona University, Flagstaff, AZ.
WEDNESDAY
#2036
45th Annual
Meeting & ToxExpo
#2049
LOSS OF REV3 PROTECTS AGAINST
CR(VI) MUTAGENESIS IN S. CEREVISIAE.
T. J. O’Brien, J. L. Fornsaglio and S. R. Patierno.
Pharmacology and Physiology, The George
Washington University Medical Center, Washington,
DC.
#2055
STUDIES ON THE ROLE OF
METALLOTHIONEIN AND SYNUCLEIN
IN LEAD-INDUCED INCLUSION BODY
FORMATION. P. Zuo, W. Qu, R. Cooper, R. A.
Goyer and M. P. Waalkes. LCC, NCI at NIEHS,
#2050
ACTIVATION OF MAP KINASES BY
HEXAVALENT CHROMIUM, MANGANESE
AND NICKEL IN HUMAN LUNG
EPITHELIAL CELLS. D. M. Tessier1 and L. E.
Pascal2. 1School of Public Health, University of
Illinois Chicago, Chicago, IL and 2Institute for
Systems Biology, University of Washington, Seattle,
WA.
#2056
ELEVATED AND PROLONGED LEAD
EXPOSURE IN FISHER 344 RATS LEADS
TO MARKED HEPATIC DIFFERENTIALLY
EXPRESSED GENES. W. E. Gato and J. C.
Means. Chemistry, Western Michigan University,
Kalamazoo, MI.
#2057
LEAD ALTERATION ON SPERM
CHROMATIN AT EJACULATION. I.
Hernandez-Ochoa, G. Martinez-Aguilar and B.
Quintanilla-Vega. Toxicology Section, CINVESTAV,
Mexico City, D.F., Mexico.
#2058
EFFECTS OF LEAD ON L-TYPE CALCIUM
CHANNEL FUNCTION IN A7R5 SMOOTH
MUSCLE CELLS. D. K. Atchison, P. J. Cobbett,
R. K. Hajela, G. D. Fink and W. D. Atchison.
Department Pharmacology/Toxicology, Mich State
University East Lansing, MI.
#2059
LEAD IN URBAN ROADWAY GRIT: A NOVEL
SOURCE AND ITS IMPLICATION. A. L. Weiss1,
2
, J. Caravanos3 and R. J. Jaeger1, 2. 1Environmental
Medicine Inc., Westwood, NJ, 2Environmental
Medicine, New York University, New York and
3
School of Health Sciences, Hunter College CUNY,
New York.
#2060
PRE-KATRINA NEW ORLEANS:
ACCUMULATION AND SYNERGY OF LEAD
AND MERCURY AND CHILDREN’S HEALTH.
H. Mielke, E. Powell, S. Alston, J. Manuel and C.
Gonzales. Basic Pharmaceutical Sciences, Xavier
University, New Orleans, LA.
#2061
MOTOR IMPAIRMENT AND CELL DEATH
IN SUBSTANTIA NIGRA COMPACTA AND
CORPUS STRIATUM AFTER MANGANESE
INHALATION. M. Avila-Costa2, 1, J. Ordonez L2, A.
Gutierrez V.2, L. Colin-Barenque2, P. Aley2, E. Jesus2,
P. Mussali1, V. Rodriguez-Lara1, G. Pinon-Zarate1,
M. Rojas-Lemus1, P. Diaz-Bech1, G. MartinezLevy1, V. Delgado1 and T. I. Fortoul1. 1Biologia
Celular y Tisular, UNAM, Mexico, D.F., Mexico and
2
Neurociencias, UNAM, Mexico, Edo Mex, Mexico.
#2062
EFFECTS OF MANGANESE ON ACONITASE
AND IRON REGULATION IN A GABAERGIC
CELL MODEL. D. R. Crooks1, M. C. Ghosh2,
T. A. Rouault2 and D. R. Smith1. 1Environmental
Toxicology, UC Santa Cruz, Santa Cruz, CA and
2
Cell Biology and Metabolism Branch, NICHD,
Bethesda, MD.
#2051
#2052
FITNESS PROFILING IN YEAST USING
PARALLEL DELETION ANALYSIS
IDENTIFIES GENES INVOLVED IN THE
RESPONSE AGAINST COPPER AND IRONINDUCED TOXICITY. W. J. Jo1, L. Alex1, G.
Guri2, C. Vulpe1 and A. Adam3. 1Nutritional Sciences
and Toxicology, University of California, Berkeley,
Berkeley, CA, 2Biochemistry, Stanford University
School of Medicine, Stanford, CA and 3LBNL,
Berkeley, CA.
COPPER, ZINC, IRON AND PROTEIN
MARKERS IN CEREBROSPINAL FLUID IN
ALZHEIMER’S DISEASE AND NORMAL
COGNITION. M. M. Nordberg1, K. Blennow2,
N. Johansson3, M. Eriksdotter-Jonhagen4 and H.
Basun5. 1Inst. Env. Med., Karolinska Institutet,
Stockholm, Sweden, 2Department Clinical
Neuroscience/Experimental Neuroscience,
Sahlgrenska Academy/university Gothenborg,
Gothenborg, Sweden, 3Inst.Env.Med., Karolinska
Institutet, Stockholm, Sweden, 4Department
Neurotec/Clinical Geriatrics, Karolinska Institutet,
Stockholm, Sweden and 5Department.Public Health/
Geriatrics, University Uppsala, Uppsala, Sweden.
WEDNESDAY
#2053
CELLULAR UPTAKE OF MAGNETIC
NANOPARTICLE IS MEDIATED THROUGH
ENERGY-DEPENDENT ENDOCYTOSIS IN
A549 CELLS. K. yu1, J. Kim1, M. Cho1, S. Park2
and J. Lee3. 1Laboratory of Toxicology, College of
Veterinary Medicine, Seoul National University,
Seoul, South Korea, 2Chemical Biology Laboratory,
School of Chemistry, Seoul National University,
Seoul, South Korea and 3Materials Chemistry
Laboratory, School of Chemistry, Seoul National
#2054
LEAD ENHANCED PROCOAGULANT
ACTIVITY MEDIATED THROUGH
PHOSPHATIDYLSERINE EXPOSURE
IN HUMAN ERYTHROCYTES:
A CONTRIBUTING FACTOR TO
CARDIOVASCULAR DISEASE. J. Noh, J. Shin,
S. Chung, O. Bae, K. Lim and J. Chung. College of
Pharmacy, Seoul National University, Seoul, South
Korea.
224
45th Annual
Meeting & ToxExpo
#2063
#2064
#2065
#2066
FINE-PARTICLE MN AND OTHER METALS
LINKED TO THE INTRODUCTION OF MMT
INTO GASOLINE IN SYDNEY, AUSTRALIA:
RESULTS OF A NATURAL EXPERIMENT.
D. Cohen2, B. Gulson1, M. Davis3, E. Stelcer2, D.
Garton2, O. Hawas2 and A. Taylor1. 1Graduate School
of the Environment, Macquarie University, Sydney,
NSW, Australia, 2ANSTO, Sydney, NSW, Australia,
3
4
Psychology, Macquarie University, Sydney, NSW,
Australia.
MANGANESE DISTRIBUTION IN PRIMATE
TISSUES AFTER WELDING FUME
EXPOSURE. I. Yu1, J. Sung1, C. Kim2, S. Yang3,
H. Chung4, H. Khang3, J. Park5, E. Park4, J. Heo2,
Y. Chung1, J. Han1 and J. Lee1. 1Laboratory
of Occupational Toxicology, OSRHI/Korean
OSHA, Daejeon, South Korea, 2Korea Institute of
Toxicology, Daejeon, South Korea, 3Department
of Radiology, Eulji University, Daejeon, South
Korea, 4Department of Preventive Medicine, Sung
Kyun Kwan University, Suwon, South Korea and
5
Department of Preventive Medicne, Chung Ang
CHANGES IN MN AND PB IN THE
ENVIRONMENT AND YOUNG CHILDREN
ASSOCIATED WITH THE INTRODUCTION
OF MMT IN GASOLINE. B. Gulson1, K. Mizon1,
M. Korsch2, H. Louie5, M. Wu5, J. Stauber3, J. Davis4
and A. Taylor1. 1Grad School of Environment,
Macquarie University, Sydney, NSW, Australia,
2
CSIRO, Sydney, NSW, Australia, 3CSIRO, Sydney,
NSW, Australia, 4EPA, Research Triangle Park, NC
and 5AGAL, Sydney, NSW, Australia.
DEMETHYLATION OF METHYLMERCURY
IN PRIMARY CULTURES OF CEREBELLAR
NEURONS AND ASTROCYTES. T. Syversen1,
E. Kummeneje1 and M. Aschner2. 1Department of
Neuroscience, Norwegian University of Science and
Technology, Trondheim, Norway and 2Department
of Pediatrics, Vanderbilt University Medical Center,
Nashville, TN.
#2067
ACCELERATED URINARY EXCRETION
OF METHYLMERCURY FOLLOWING
ADMINISTRATION OF ITS ANTIDOTE NACETYLCYSTEINE REQUIRES Mrp2/Abcc2,
THE APICAL MULTIDRUG RESISTANCEASSOCIATED PROTEIN. M. S. Madejczyk, T. A.
Simmons-Willis and N. Ballatori. Environmental
Medicine, University of Rochester School of
Medicine, Rochester, NY.
#2068
INTERFERENCE OF NICKEL ON IRON
HOMEOSTASIS. H. Chen, T. L. Davidson, G.
Kang and M. Costa. Department of Environmental
Medicine, New York University, Tuxedo, NY.
#2069
CARCINOGENIC AND TOXICOLOGICAL
EFFECTS OF EMBEDDED TUNGSTEN AND
TUNGSTEN ALLOYS. L. E. Roszell, B. Paulus
and G. J. Leach. U.S. Army CHPPM, Aberdeen
Proving Ground, MD.
225
#2070
90-DAY ORAL TOXICITY OF SODIUM
TUNGSTATE IN SPRAGUE-DAWLEY RATS.
G. A. Parker1, 2, P. A. Beall3 and W. C. McCain3.
1
Biotechnics, Inc., Hillsborough, NC, 2Pathology,
WIL Research Laboratories, Ashland, OH and
3
Toxicology, U.S. Army Center for Health Promotion
MD.
#2071
BLOOD URANIUM CONCENTRATION AS
A BIOMARKER OF HUMAN EXPOSURE
TO DEPLETED URANIUM (DU) IN GULF
WAR I VETERANS WITH EMBEDDED
FRAGMENTS. K. S. Squibb1, T. Todorov2, J.
Centeno2, S. Engelhardt1 and M. McDiarmid1.
1
University of Maryland School of Medicine,
Baltimore, MD and 2Armed Forces Institute of
Pathology, Washington, DC.
#2072
INDICATIONS FOR SURGICAL REMOVAL
OF DEPLETED URANIUM (DU) SHRAPNEL
IN GULF WAR I VETERANS. M. McDiarmid1,
2
, S. Engelhardt1 and K. S. Squibb2. 1Department of
Veterans’ Affairs Medical Center, Baltimore, MD
and 2UM School of Medicine, Baltimore, MD.
#2073
EFFECT OF ORGANIC ACID LIGANDS
ON URANIUM(VI) TOXICITY. C. J. Kuehl1,
V. H. Coryell1, R. C. Lantz2 and D. M. Stearns1.
1
Department of Chemistry, Northern Arizona
University, Flagstaff, AZ and 2Cell Biology and
Anatomy, University of Arizona, Tucson, AZ.
#2074
URANIUM INHIBITS THE BINDING OF
TRANSCRIPTIONAL REGULATORS TO
DNA. R. Lantz1, D. J. Segal2 and D. M. Stearns3.
1
Cell Biology and Anatomy, University of
Arizona, Tucson, AZ, 2Medical Pharmacology and
Toxicology, UC Davis, Davis, CA and 3Chemistry
and Biochemistry, Northern Arizona University,
Flagstaff, AZ.
#2075
DETERMINATION OF VANADIUM TISSUE
CONCENTRATIONS IN BRAIN, KIDNEY,
LIVER, LUNG, TEETH AND TESTES AFTER
DIFFERENT EXPOSURE TIMES. T. I. Fortoul1,
M. Avila-Costa2, L. Saldivar3, G. Espejel-Maya3, L.
Coli-Barenque2, P. Bizarro-Nevarez1, P. MussaliGalante1, V. Rodriguez-Lara1, G. Pinon-Zarate1, G.
Martinez-Levy1, M. Rojas-Lemus1 and V. Delgado1.
1
Biologia Celular y Tisular, Facultad de Medicina,
UNAM, Mexico City, Mexico, 2NEUROCIENCIAS,
FES IZTACALA, EDO. MEXICO, Mexico and
3
FAC. QUIMICA, UNAM, MEXICO CITY, Mexico.
#2076
GENOTOXIC POTENTIAL OF INHALED
VANADIUM ON MOUSE TESTES. P. mussali1,
M. Avila-Costa2, L. Colin-Barenque2, P. BizarroNevares1, T. Fortoul1 and E. Tovar-Sanchez3.
1
Biologia celular y tisular, Universidad Nacional
Autonoma de Mexico, Mexico City, Mexico,
2
Departamento de Neurociencias, Universidad
Nacional Autonoma de Mexico, Mexico City,
Mexico and 3Centro de educacion ambiental e
investigacion Sierra de Huautla, Universidad
Autonoma de Estado de Morelos, Cuernavaca,
Morelos, Mexico.
WEDNESDAY
45th Annual
Meeting & ToxExpo
#2077
#2078
COMPARISON OF METALS IN HUMAN
MILK AND URINE USING TRACE
MULTIELEMENT ANALYSES. S. E. Fenton1,
J. L. Rayner3, B. Heidenfelder2, A. M. Levine4, L.
Iordanidis4, J. E. Gallagher2 and E. P. Hines1. 1ORD/
NHEERL, Reproductive Toxicology Division, U.S.
EPA, Research Triangle Park, NC, 2ORD/NHEERL,
Human Studies Division, U.S. EPA, Chapel Hill,
NC, 3DESE, UNC, Chapel Hill, NC and 4RJ Lee
Group, Monroeville, PA.
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
AN ASSAY FOR TOXIC EVALUATION
OF BIOAVAILABLE TOXICANTS (E.G.
ARSENIC AND URANIUM) USING THE A
LUMINESCENT BACTERIAL BIOSENSOR.
C. K. Begay1, M. Yellowhair1, J. W. Neilson2, R.
M. Maier2 and A. J. Gandolfi1. 1Department of
Pharmacology & Toxicology, University of Arizona,
Tucson, AZ and 2Department of Soil, Water and
Environmental Science, University of Arizona,
Tucson, AZ.
POSTER SESSION: CARCINOGENESIS BIOASSAY
Chairperson(s): Gary Williams, New York Medical College, Valhalla, NY
and Joseph Landolph, University of Southern California, Los Angeles, CA.
#2079
HEAVY METALS REGULATE THE NAD(P)H:
QUINONE OXIDOREDUCTASE 1 (NQO1)
GENE EXPRESSION THROUGH BOTH AHRAND NRF2-MEDIATED TRANSCRIPTIONAL
MECHANISMS. H. M. Korashy and A. O. El-Kadi.
Faculty of Pharmacy & Pharmaceutical Sciences,
University of Alberta, Edmonton, AB, Canada.
#2080
TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL MECHANISMS
INVOLVED IN THE MODULATION OF
Cyp1a1 BY As3+, Cd2+, AND Cr6+. R. H. Elbekai
and A. O. El-Kadi. University of Alberta, Edmonton,
AB, Canada.
#2081
THE EFFECT OF ARSENITE AND CADMIUM
ON UROTSA CELLS TRANSFORMED WITH
ARSENITE OR CADMIUM. M. Sens, S. Somji, S.
H. Garrett and D. A. Sens. pathology, University of
north dakota, Grand Forks, ND.
#2082
IN VITRO EFFECTS OF METAL MIXTURES
ON RAW 264.7 MONOCYTES. P. A. Potnis, R.
J. Mitkus, J. L. Powell, K. S. Squibb and K. Strauss.
UM School of Medicine, Baltimore, MD.
WEDNESDAY
226
#2083
MULTICENTER CLINICAL STUDY TO
ASSESS THE POTENTIAL RISK OF
EXPOSURE TO LIPID PEROXIDATION
PRODUCTS IN SOYA BEAN OIL FROM
TRILUCENT BREAST IMPLANTS. G.
Williams1, J. Caldwell2, D. Armstrong3, R. Bevan4, J.
Chipman5, M. J. Iatropoulos1, A. Jeffrey1, J. Lunec4,
J. Nair6, D. Page7, B. Reeves8, A. Richardson9
and D. Williams2. 1NY Medical Coll., Valhalla,
NY, 2Universtiy of. Liverpool, Liverpool, United
Kingdom, 3Universtiy of. Florida, Gainesville,
FL, 4Universtiy of. Leicester, Leicester, United
Kingdom, 5Universtiy of. Birmingham, B’ham,
United Kingdom, 6German Cancer Center,
Heidelberg, Germany, 7Vanderbilt University,
Vanderbilt, TN, 8London School of Hygiene,
London, United Kingdom and 9AEI, Inc., London,
United Kingdom.
#2084
EVALUATION OF INDUCTION OF
ABERRANT FOCI CRYPT IN THE COLON OF
RATS TREATED WITH THE COMMERCIAL
DYE PRODUCT CI DISPERSE BLUE 291.
F. Pinheiro1, S. B. Barros1 and G. A. Umbuzeiro2.
1
Clinical and Toxicological Analyses, University of
Sao Paulo, Sao Paulo, SP, Brazil and 2CETESB_Cia.
Tecnologia de Saneamento Ambiental, Sao Paulo,
SP, Brazil.
#2085
GENOTOXICITIES OF NICKEL REFINERY
SAMPLES IN 10T1/2 MOUSE EMBRYO
CELLS. J. R. Landolph1, 2, 3, A. Andrade1, A.
Hamirani1, H. Vekaria1, M. Scheiner1, D. Castillo1
and S. Norhadian1. 1Department of Molecular
Microbiology and Immunology, University of
Southern California, Los Angeles, CA, 2Department
of Pathology, University of Southern California,
Los Angeles, CA and 3Department of Molecular
Southern California, Los Angeles, CA.
#2086
MONOMETHYLARSONOUS ACID
(MMAIII) IS CARCINOGENIC IN MICE. M.
Krishnamohan, A. A. Seawright and J. C. Ng. The
University of Queensland, National Research Centre
for Environmental Toxicology, Brisbane, QLD,
Australia. Sponsor: M. Hughes.
#2087
HISTOPATHOLOGIC CHARACTERISTICS
OF VISUALLY IDENTIFIED SKIN TUMORS
IN UVR-IRRADIATED HAIRLESS MICE. P. D.
Forbes1, C. P. Sambuco1, D. B. Learn1, M. Arocena1
and A. M. Hoberman2. 1Center for Photobiology,
Charles River Laboratories Preclinical Services,
Horsham, PA and 2Charles River Laboratories
Preclinical Services, Horsham, PA.
45th Annual
Meeting & ToxExpo
HEMANGIOSARCOMAS INDUCED IN MICE
BY N-(4-HYDROXYPHENYL) RETINAMIDE.
J. A. Crowell1 and E. I. Goldenthal2. 1Division
of Cancer Prevention, National Cancer Institute,
Bethesda, MD and 2MPI Research, Mattawan, MI.
#2089
PRELIMINARY EVIDENCE OF
UROLITHIASIS WITH MURAGLITAZARRELATED URINARY BLADDER
CARCINOGENESIS IN MALE RATS. S.
Tannehill-Gregg1, M. Cano2, L. Tomlinson1,
S. Cohen2, T. Sanderson1, B. Schilling1 and M.
Dominick1. 1Bristol-Myers Squibb, Mt. Vernon,
IN and 2University of Nebraska Medical Center,
Omaha, NE.
#2090
#2095
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: MALE REPRODUCTIVE TOXICITY
EVALUATIONS
Chairperson(s): Aramandla Ramesh, Meharry Medical College, Nashville,
TN and Paul Foster, NIEHS, Research Triangle Park, NC.
RESULTS OF 2-YEAR CARCINOGENICITY
EVALUATIONS OF PRAMLINTIDE IN MICE
AND RATS. R. Hiles1, 2. 1CRHiles Consulting,
Butler, TN and 2Amylin Pharmaceuticals, Inc., San
Diego, CA.
#2091
CARCINOGENICITY VARIATION OF PCRESIDINE WHILE USED AS A POSITIVE
CONTROL CHEMICAL IN THE P53 MOUSE
SHORT-TERM CARCINOGENICITY TEST
MODEL. Y. Wang1, P. Miller1, B. Bassett1, S.
Manetz1, G. Wolfe1 and A. Purmal2. 1Gene Logic Inc.,
Gaithersburg, MD and 2Panacos Pharmaceuticals,
134 Coolidge Avenue, MA.
#2092
ALTERNATIVE METHODS FOR
CARCINOGENICITY TESTING: VALIDATION
OF THE P53 +/- MODEL. C. Banks, A. Adamou
and L. Chouinard. Toxicology, Charles River
Canada.
#2093
#2094
A TRANSOMIC BIOMARKER COMPARISON
FOR PREDICTING TWO-YEAR RODENT
CANCER BIOASSAYS. R. S. Thomas1, L. J. Pluta1,
T. J. Page1, J. M. MacDonald2, J. Winnike2 and R.
D. Wolfinger3. 1CIIT Centers for Health Research,
Research Triangle Park, NC, 2University of North
Carolina, Chapel Hill, NC and 3SAS Institute, Cary,
NC.
A DATA-BASED ASSESSMENT OF
ALTERNATIVE STRATEGIES FOR
IDENTIFICATION OF POTENTIAL HUMAN
CANCER HAZARDS. N. Doerrer4, A. Boobis1,
J. Bucher2, S. Cohen3, D. Jacobson Kram5, J.
MacDonald6 and D. Wolf7. 1Imperial College
London, London, United Kingdom, 2NIEHS
National Toxicology Program, Research Triangle
Park, NC, 3University of Nebraska Medical Center,
Omaha, NE, 4ILSI Health and Environmental
Sciences Institute, Washington, DC, 5FDA Center
for Drug Evaluation and Research, Rockville, MD,
6
Schering-Plough Research Institute, Kenilworth,
NJ and 7EPA National Health and Environmental
Effects Research Laboratory, Research Triangle
Park, NC.
CARCINOGENICITY STUDIES OF
MURAGLITAZAR, A DUAL PPAR ALPHA
AND GAMMA AGONIST, IN MICE AND RATS.
T. Sanderson1, M. Dominick1, B. Schilling1, C. R.
Waites1, D. Minnema2, R. Voelker2 and B. Ulland2.
1
Bristol-Myers Squibb, Mt. Vernon, IN and 2Covance
Laboratories, Vienna, VA.
227
#2096
INFLUENCE OF SUBCHRONIC INHALED
BENZO(A)PYRENE ON MALE FERTILITY
INDICES OF F-344 RATS. A. RAMESH1, D.
Lunstra2, M. S. Niaz3, F. Inyang3, D. B. Hood1 and
A. E. Archibong3. 1Biomedical Sciences, Meharry
Medical College, Nashville, TN, 2Meat Animal
Research Center, USDA, Nebraska and 3Obstetrics
& Gynecology, Meharry Medical College,
Nashville, TN.
#2097
DIISOBUTYL PHTHALATE HAS
COMPARABLE ANTI-ANDROGENIC
EFFECTS IN RAT FETAL TESTIS TO
DIBUTYL PHTHALATE. M. Dalgaard, J. Borch,
M. Petersen and A. Vinggaard. Department of
Toxicology, Danish Institute for Food and Veterinary
Research, Soeborg, Denmark. Sponsor: E. Gray.
#2098
NF-κB ACTIVATION ELICITED BY IONIZING
RADIATION IS PRO-APOPTOTIC IN TESTIS.
R. Rasoulpour and K. Boekelheide. Brown
University, Providence, RI.
#2099
AKT1 SUPPRESSES RADIATION-INDUCED
GERM CELL APOPTOSIS IN VIVO. T.
Rasoulpour1, K. DiPalma2, B. Kolvek1 and M.
Hixon1. 1Pathology, Brown University, Providence,
RI and 2Biology, Providence College, Providence,
RI.
#2100
EFFECT OF ESTROGENIC EXOGENOUS
CHEMICALS EXPOSURE ON CORTACTIN
PROTEIN EXPRESSION IN MOUSE TESTIS.
M. Yoshida1, R. Anahara1, M. Kai2, F. Ishino2 and C.
Mori1, 3. 1Department of Bioenvironmental medicine,
Chiba, Japan, 2Department of Epigenetics, Tokyo
Medical & Dental University, Tokyo, Japan and
3
Dnvironmental Health Science Project for Future
Generation, Graduate School of Medicine, Chiba
University, Chiba, Japan.
WEDNESDAY
#2088
45th Annual
Meeting & ToxExpo
#2101
DETERMINATION OF THE DI-(2ETHYLHEXYL)PHTHALATE (DEHP) NOAEL
FOR REPRODUCTIVE DEVELOPMENT IN
THE RAT: IMPORTANCE OF RETENTION OF
EXTRA F1 ANIMALS. P. M. Foster1, J. Bishop1,
R. E. Chapin2, G. E. Kissling1 and G. W. Wolfe3.
1
NIEHS, Research Triangle Park, NC, 2Pfizer,
Groton, CT and 3Gene Logic, Gaithersburg, MD.
#2102
THE CONCOMITANT IN VIVO EXPOSURE
OF YOUNG MALE ADULT RATS TO THE
PESTICIDE METHOXYCHLOR (M) AND
THE ANTIESTROGEN ICI 182, 780 (ICI)
DOES NOT ALTER THE DECLINES IN
SEMINAL VESICLE (SV) WEIGHT, SERUM
TESTOSTERONE (T) LEVEL, EX VIVO
LEYDIG CELL (LC) T FORMATION, OR
EX VIVO LC P450 CHOLESTEROL SIDECHAIN CLEAVAGE (P450SCC) ACTIVITY
EXERTED BY TREAMENT WITH M ALONE.
E. P. Murono1, 2, R. C. Derk1 and Y. Akgul2, 1.
1
Pathology and Physiology Research Branch,
NIOSH, Morgantown, WV and 2Physiology and
Pharmacology, West Virginia University School
of Medicine, Morgantown, WV. Sponsor: V.
Castronova.
#2103
HYPOSPERMATOGENESIS AND
CHARACTERISATION OF KEY STAGES OF
SPERMATOGENESIS IN THE TESTIS OF THE
BEAGLE DOG – A CASE STUDY. A. Shaha.
Covance Laboratories Ltd., Harrogate, United
Kingdom. Sponsor: D. Everett.
WEDNESDAY
#2104
MALE SEXUAL MATURITY AND ADVERSE
EFFECTS IN TESTES OF MACACA
FASCICULARIS. O. Foulon, P. Desert, M. Attia and
R. Forster. CIT, Evreux, France.
#2105
COMPARISON OF PRECISION AND
ACCURACY OF PROSTATE AND
TESTIS ULTRASONOGRAPHY IN THE
CYNOMOLGUS MONKEY. G. F. Weinbauer1, M.
Niehaus1 and A. Kamischke2. 1Covance, Muenster,
Germany and 2St Barbara Clinic Heessen, Hamm,
Germany.
#2106
NON-INVASIVE UROFLOW ANALYSIS IN
THE CYNOMOLGUS MONKEY. M. Niehaus
and G. F. Weinbauer. Covance, Muenster, Germany.
#2107
EFFECTS OF ENVIRONMENTAL TOBACCO
SMOKE ON RHESUS MONKEY SPERM
FUNCTION. P. Hung1, 2, M. G. Miller3 and C.
A. VandeVoort1, 2. 1California National Primate
Research Center, UC Davis, Davis, CA, 2Molecular,
Cellular, and Integrative Physiology, UC Davis,
Davis, CA and 3Environmental Toxicology, UC
Davis, Davis, CA.
#2108
METHYL-PARATHION INDUCES SPERM
DNA DAMAGE IN MICE. B. Pina-Guzman, M.
Solis-Heredia, E. Rojas-Garcia and B. QuintanillaVega. Toxicology Section, CINVESTAV, Mexico
City, D.F., Mexico.
228
#2109
BIOCHEMICAL ANALYSIS OF ETHYLENE
GLYCOL MONOETHYL ETHER INDUCED
CELL DEATH IN THE TESTES OF RAT. R.
Wang1, M. Suda1, N. Jia2, X. Gao2 and T. Honma1.
1
National Institute of Industrial Health, Kawasaki,
Japan and 2Beijing Diseases Control and Prevention
Center, Beijing, China. Sponsor: X. Yu.
#2110
IDENTIFICATION AND
CHARACTERIZATION OF NOVEL AND
UNKNOWN GENES AND EFFECTS OF
NEONATAL DIETHYLSTILBESTROL
TREATMENT ON THESE GENES
EXPRESSION LEVELS IN MOUSE
EPIDIDYMIS. K. Yamazaki1, 2, T. Adachi3, K.
Sato1, 2, Y. Yanagisawa1, 2, H. Fukata1, 2, N. Seki4,
C. Mori1, 2, 5 and M. Komiyama1, 2, 5. 1Department
of Bioenvironmental Medicine, Graduate School
of Medicine, Chiba University, chiba, Japan,
2
Environmental Health Science Project for Future
Generations, Graduate School of Medicine, Chiba
University, chiba, Japan, 3Department of Genomic
Drug Discovery Science, Graduate School of
Pharmaceutical Sciences, Kyoto University, kyoto,
Japan, 4Department of Functional Genomics,
chiba, Japan and 5Center for Environment, Health
and Field Sciences, Chiba University, kashiwa,
chiba, Japan.
#2111
IDENTIFICATION OF PROTEIN ADDUCTS
AND GENE EXPRESSION CHANGES AFTER
THE TESTICULAR TOXICANT MOLINATE.
A. Rodriguez1, A. R. Campbell1, W. T. Jewell2, J.
L. Spearow1 and M. G. Miller1. 1Environmental
Toxicology, UC Davis, Davis, CA and 2Molecular
Structure Facility, UC Davis, Davis, CA.
#2112
INTER-SPECIES COMPARISION OF
LIVER AND TESTICULAR MICROSOMAL
METABOLISM OF BENZO(A)PYRENE.
A. E. Archibong1, J. J. Ford2 and A. RAMESH3.
1
Obstetrics & Gynecology, Meharry Medical
College, Nashville, TN, 2Meat Animal Research
Center, USDA, Nebraska and 3Biomedical Sciences,
Meharry Medical College, Nashville, TN.
#2113
EXTRAPOLATION OF TOXIC HEALTH
OUTCOMES IN RODENTS DOSED WITH
DI(2-ETHYLHEXYL)PHTHALATE TO
SELECTED HUMAN POPULATIONS. M.
J. Silva1, E. L. Gray2, L. L. Needham1 and A. M.
Calafat1. 1National Center for Environmental Health,
Centers for Disease Control and Prevention, Atlanta,
GA and 2National Health and Environmental Effects
Research Laboratory, U.S. EPA, Research Triangle
Park, NC.
#2114
INDUCTION OF PC3 CELL DEATH AND DNA
STRAND BREAKS BY BENZO[A]PYRENE7, 8-DIOL-9, 10-EPOXIDE (BPDE). O. F.
Nwagbara1, S. F. Darling-Reed2, R. D. Thomas2 and
R. D. Gragg1. 1Environmental Sciences Institute,
Florida A&M University, Tallahassee, FL and
2
College of Pharmacy and Pharmaceutical Sciences,
Florida A&M University, Tallahassee, FL.
45th Annual
Meeting & ToxExpo
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
#2121
VALIDATION OF THE NQO1 ACTIVE SITE
MODEL BY DOCKING STUDIES AND
MECHANISTIC STUDIES OF SELECTIVE
TOXICITY OF GOOD LAVENDAMYCIN
SUBSTRATES OF NQO1. M. Hassani1, W. Cai2,
J. Gerdes1, M. Behforouz2 and H. Beall1. 1The
University of Montana, Missoula, MT and 2Ball
State University, Muncie, IN.
#2122
ADDUCTION OF CYTOCHROME C BY
BENZOQUINONE AND (GLUTATHION-SYL)-1, 4-BENZOQUINONE CAUSES A LOSS
OF PROTEIN FUNCTION. A. A. Fisher1,
M. T. Labenski1, V. Gokhale1, S. B. Bratton2,
T. J. Monks1 and S. S. Lau1. 1Pharmacology/
Toxicology, University of Arizona, Tucson, AZ and
2
Pharmacology/Toxicology, University of Texas,
Austin, TX.
#2123
PROMOTION OF LIVER GST-P FOCI
BY A CHEMICAL MIXTURE OF
HEXACHLOROBENZENE (HCB) AND
3, 3’, 4, 4’, 5-PENTACHLOROBIPHENYL
(PCB126): INTEGRATION OF COMPUTER
MODELING AND BIOLOGY OF CLONAL
GROWTH. Y. LU1, M. Lohitnavy1, M. Reddy1, O.
Lohitnavy1, E. Eickman1, A. Ashley1, Y. Xu2 and
R. Yang1. 1Environmental & Radiological Health
Sciences, Colorado State University, Ft Collins,
CO and 2McArdle Laboratory for Cancer Research,
University of Wisconsin, Madison, WI.
#2124
STOCHASTIC SIMULATION TO OBTAIN
THE EXACT SOLUTION OF THE TWOSTAGE CLONAL GROWTH MODEL. R.
Conolly1, K. S. Crump2 and H. J. Clewell3. 1National
Center for Computational Toxicology, U.S. EPA,
Research Triangle Park, NC, 2Environ Health
Sciences Institute, Ruston, LA and 3Center for
Human Health Assessment, CIIT, Centers for Health
#2125
DEVELOPMENT OF A PHARMACOKINETICDRIVEN COMPUTATIONAL FLUID
DYNAMICS MODEL TO PREDICT NASAL
EXTRACTION OF HYDROGEN SULFIDE IN
RATS. J. D. Schroeter, J. S. Kimbell, M. E. Andersen
and D. C. Dorman. CIIT Centers for Health
#2126
ONGOING DEVELOPMENT OF BIOTRANS:
A TOOL FOR PREDICTIVE XENOBIOTIC
METABOLOMICS OF CHEMICAL
MIXTURES. A. N. Mayeno1, R. Yang1 and B.
Reisfeld1, 2. 1Environmental & Radiological Health
Sciences, Colorado State University, Fort Collins,
CO and 2Chemical & Biological Engineering,
Colorado State University, Fort Collins, CO.
#2127
AN EXPLORATORY PARTICOKINETIC
MODEL FOR ADDRESSING THE UNIQUE
CHALLENGES OF NANOPARTICLE
DOSIMETRY IN VITRO. J. G. Teeguarden, P. M.
Hinderliter and J. G. Pounds. Biological Monitoring
and Modeling, Pacific Northwest National
Laboratory, Richland, WA.
POSTER SESSION: COMPUTATIONAL TOXICOLOGY
Chairperson(s): Rory Conolly, U.S. EPA, Research Triangle Park, NC and
Elizabeth Gross, CIIT, Research Triangle Park, NC.
#2115
A HOLISTIC APPROACH TO HAZARD
IDENTIFICATION BASED ON STRUCTUREACTIVITY RELATIONSHIPS – FROM DATA
TO MODELS. R. A. Kemper1, J. B. Majeska1,
C. Yang2 and J. Archer2. 1Toxicology and Safety
Assessment, Boehringer-Ingelheim Pharmaceuticals
Inc., Ridgefield, CT and 2Leadscope Inc., Columbus,
OH.
#2116
DYNAMICS OF EXTRACELLULAR SIGNALREGULATED KINASE (ERK) ACTIVATION
IN DEVELOPING CEREBELLAR GRANULE
CELLS (CGC): A SYSTEMS BIOLOGYORIENTED STUDY. Q. Zhang1, W. Mundy2
and R. Conolly2. 1Centers for Health Research,
CIIT, Research Triangle Park, NC and 2U.S. EPA,
#2117
A THREE-DIMENSIONAL ANATOMICAL
MAP OF THE MAJOR EPITHELIAL TYPES
IN THE B6C3F1 MOUSE NASAL PASSAGES.
E. A. Gross1, D. R. Joyner1, 2, A. M. Jarabek1,
3
and J. S. Kimbell1. 1CIIT Centers for Health
Research, Research Triangle Park, NC, 2Currently,
UNC, Chapel Hill, NC and 3National Center for
Environmental Assessment, U.S. EPA, Washington,
DC.
#2118
CHEMICALLY-INDUCED SKIN IRRITATION:
COMPUTATIONAL MODEL OF
INTRACELLULAR SIGNALING PATHWAYS
THAT MEDIATE INFLAMMATORY
RESPONSE. M. S. Breen1, Y. Zeng2, Q. Zhang3, J.
N. McDougal4, P. Shi4 and R. B. Conolly1. 1NCCT,
U.S. EPA, Research Triangle Park, NC, 2Purdue
University, West Lafayette, IN, 3CIIT Centers for
Health Research, Research Triangle Park, NC and
4
Wright State University, Dayton, OH.
#2119
PARTICLE DEPOSITION IN THE LUNG
CENTRAL AIRWAYS. B. Asgharian, S. Gudi and
B. A. Wong. Division of Computational Biology,
CIIT Centers for Health Research, Research Triangle
Park, NC.
#2120
NON-SPECIFIC TOXICITY REDUCTION
BY ENCAPSULATING TOXINS IN
NANOLIPOSOMES: A THEORETICAL
MODEL. D. Dimitrov and I. A. Sidorov. NCI, NIH,
Frederick, MD. Sponsor: L. Anderson.
229
WEDNESDAY
45th Annual
Meeting & ToxExpo
#2128
NETWORK ANALYSIS FOR TOXICITY
PREDICTION OF ENDOCRINE DISRUPTORS
USING KEYMOLNET. H. Sato1, J. Kanno2, A.
Takagi2, A. Ono2, R. Taniguchi1, M. Ogura1 and
A. Itai1. 1Bioinformatics, Institute of Medicinal
Molecular Design, Inc. (IMMD), Tokyo, Japan and
2
Cellular & Molecular Toxicology Division, National
Institute of Health Sciences, Tokyo, Japan. Sponsor:
T. Inoue.
#2133
DEVELOPMENT OF PHOSPHOLIPIDOSIS
ASSAYS IN RAT HEPATOCYTES AND HEPG2
CELLS USING PHOSPHOLIPID PROBE NBDPE OR NILE RED STAIN. N. Bhandari, D. J.
Figueroa, J. W. Lawrence and D. L. Gerhold. Merck
Research Laboratories, West Point, PA.
#2134
INVOLVEMENT OF TRANS-4-HYDROXY-2NONENAL-MODIFIED PROTEINS IN LEC
RAT HEPATIC LESIONS. A. Nishikawa1, T.
Imazawa1, 2, K. Kanki1, Y. Kuroiwa1 and M. Hirose1.
1
Pathology, National Institute of Health Sciences,
Tokyo, Japan and 2National Institute of Biomedical
Innovation, Osaka, Japan.
#2135
MODULATION OF BILE ACID EFFLUX IN
RAT HEPATOCYTES:A NOVEL METHOD
FOR QUANTIFICATION OF TRANSPORTER
INHIBITION. J. Hopwood, C. Summers, G.
Barrett, K. Jones and G. Kenna. Safety Assessment,
AstraZeneca, Cheshire, United Kingdom. Sponsor:
F. Pognan.
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: LIVER II
Chairperson(s): Glenn Sipes, University of Arizona, Tucson, AZ and Lei
Guo, USFDA-NCTR, Jefferson, AR.
WEDNESDAY
#2129
TWENTY EIGHT DAYS OF ORAL
ISOTRETINOIN (13-CIS-RETINOIC ACID)
TREATMENT INDUCES EPIGENETIC
CHANGES IN ADULT SPRAGUE-DAWLEY
RATS. F. J. Cisneros1, S. A. Ferguson2, C. K. Wise3
and L. A. Poirier3. 1Preclinical Services, Charles
River Laboratories, Horsham, PA, 2Division of
Neurotoxicology, National Center for Toxicological
Research/U.S. FDA, Jefferson, AR and 3Division
of Molecular Epidemiology, National Center for
Toxicological Research/U.S. FDA, Jefferson, AR.
#2136
DIFFERENTIAL COVALENT ADDUCT
BIODISTRIBUTION OF DICLOFENAC AND
A DICLOFENAC SULFURATED ESTER IN
RAT LIVER AND SMALL INTESTINE. M. M.
Ong1, A. Sparatore2, P. del Soldato3, P. K. Moore1,
M. Treinen-Moslen4 and Universtiy of. A. Boelsterli1,
5 1
. Pharmacology, NUS, Singapore, Singapore,
2
University of Milan, Milan, Italy, 3CTG Pharma,
Milan, Italy, 4University of Texas Medical Branch,
Galveston, TX and 5Pharmacy, NUS, Singapore,
Singapore.
#2130
DIETARY VITAMIN E SUPPLEMENTATION
ENRICHES HEPATIC MITOCHONDRIA
WITH PROTECTIVE LEVELS OF ALPHA
TOCOPHEROL. T. Rhim2, J. Zhang1, S. K.
Sivaraman1 and M. W. Fariss1. 1Pharmaceutical
Sciences, University of Colorado Health Sciences
Center, Denver, CO and 2Biotechnology, Sangji
University, Wonju, Kangwon-do, South Korea.
#2137
INHIBITED TISSUE REPAIR IS THE
MECHANISM OF POTENTIATION
OF THIOACETAMIDE-INDUCED
HEPATOTOXICITY IN DIABETIC RATS. S. S.
Devi, B. K. Philip and H. M. Mehendale. Toxicology,
The University of Louisiana at Monroe, Monroe,
LA.
#2138
#2131
4-HYDROXYACETOPHENONE-INDUCED
CHOLERESIS IN RATS IS MEDIATED BY AN
MRP2- AND GLUTATHIONE-DEPENDENT
MECHANISM. C. Mahagita1, 2, K. Tanphichai1,
N. Ballatori2 and P. Piyachaturawat1. 1Physiology
Department, Mahidol University, Bangkok, Thailand
and 2Environmental Medicine, University of
#2132
HEPATIC GENE EXPRESSION CHANGES
ASSOCIATED WITH LIPID METABOLISM
WITH AGE IN THE FISCHER RAT. K. Mori1,
2
, J. S. Parker3, E. K. Lobenhofer4, E. Ney2, J.
H. Roycroft2, D. P. Orzech2, P. E. Blackshear5,
R. D. Irwin2 and G. A. Boorman2. 1Drug Safety
Research Laboratory, Daiichi Pharmaceutical Co.,
Ltd., Edogawa-ku, Tokyo, Japan, 2Environmental
Toxicology Program, National Institute of
Environmental Health Sciences, Research Triangle
Park, NC, 3Constella Group, Inc., Research Triangle
Park, NC, 4Paradigm Array Labs, A service unit
of Icoria, Inc., Research Triangle Park, NC and
5
Integrated Laboratory Systems, Inc., Research
Triangle Park, NC.
INHIBITION OF HEPATOBILIARY
TRANSPORT AS A PREDICTIVE METHOD
FOR CLINICAL HEPATOTOXICITY OF
NEFAZODONE. V. Kostrubsky1, S. Strom2,
A. Kalgutkar3, S. Kulkarni1, J. Atherton4, R.
Mireles3, R. Kubik1, J. Hanson1, E. Urda1 and A.
Mutlib4. 1Safety Sciences, Pfizer, Ann Arbor, MI,
2
Pathology, University of Pittsburgh, Pittsburgh, PA,
3
Metabolism, Pfizer, Groton, CT and 4Metabolism,
Pfizer, Ann Arbor, MI. Sponsor: M. Bleavins.
#2139
METHYLENEDIANILINE INJURY TO
LIVERS OF TR- [LIVER CANALICULAR
MRP2 TRANSPORTER-DEFICIENT] RATS
IS CORRELATED WITH ALTERATIONS
IN LIPID METABOLISM. M. F. Kanz, B.
Ramasubramanian, Y. Chen and M. Treinen-Moslen.
Pathology, University of Texas Medical Branch,
Galveston, TX.
230
45th Annual
Meeting & ToxExpo
ENVIRONMENTAL FACTORS OUTWEIGH
DRUG-RESPONSE FACTORS AT EARLY
TIME POINTS IN TOXICOGENOMIC
EXPERIMENTS. D. Mulhern1, S. Yokokawa1,
Y. Ohshima1, Y. Adachi1, A. Kohara2, T. Suzuki3,
N. Miyata4, S. Ninomiya1 and T. Sudo1. 1ADME/
TOXICOLOGY Research Institute, Daiichi Pure
Chemicals Co., Ltd., Tokaimura, Japan, 2Division
of Genetics and Mutagenesis, National Institute of
Health Sciences, Tokyo, Japan, 3Division of Cellular
& Gene Therapy Products, National Institute of
Health Sciences, Tokyo, Japan and 4Division of
Organic Chemistry, National Institute of Health
Sciences, Tokyo, Japan. Sponsor: T. Inoue.
#2141
THE USE OF RAT LIVER SLICES IN
COMPOUND SELECTION. A. Reising1, R.
Bruno1, E. Cruz1, A. Garami2, S. Mangialaio2, A.
Wolf2 and K. Rose1. 1Biomarker Development,
Novartis Pharmaceuticals, East Hanover, NJ and
2
Novartis Pharma AG, Basel, Switzerland.
#2142
INTEGRATED OMIC ANALYSIS OF HEPATIC
TUMOR PROMOTERS EFFECTS IN RAT
LIVER. A. Naito1, L. Schnackenberg1, R. Holland1,
L. Muskhelishvili2, D. Morris3, R. Baillie3, S.
Dial1, C. Melvin1, J. Fuscoe1, H. Fang1, W. Tong1,
R. Beger1, R. Edmondson1 and Y. Dragan1.
1
Division of systems Toxicology, NCTR, Jefferson,
AR, 2Toxicologic Pathology Associates, NCTR,
Jefferson, AR and 3Lipomics Technologies, Inc.,
West Sacramento, CA.
#2143
#2144
#2145
#2146
IN SILICO EVALUATION OF
HEPATOTOXICITY USING DEREK FOR
WINDOWS. R. R. Note1, M. L. Patel1, C. A.
Marchant1 and N. Greene2. 1Lhasa Limited, Leeds,
United Kingdom and 2Safety Sciences - Groton,
Pfizer Global Research & Development, Groton,
CT.
CHARACTERIZATION OF A THREEDIMENSIONAL HUMAN LIVER
BIOREACTOR. M. A. Christie1, K. M. Young1,
J. W. Ludlow1, S. O. Sherwood1, M. B. Johnston1,
G. L. Kedderis1, N. G. Hentz1, C. M. Seagle2,
J. H. Winnike2 and J. M. Macdonald2. 1Admet
Technologies, Durham, NC and 2Biomedical
Hill, NC.
ALTERED BILIARY CLEARANCE OF
THYROXINE (T4) AND T4-GLUCURONIDE
(T4-G) IN MRP2-DEFICIENT RATS: EFFECTS
OF PHENOBARBITAL (PB) AND DPC-904. L.
W. LeCureux1, M. Z. Dieter2, H. Wong3, B. Gemzik1,
B. D. Car1, C. D. Klaassen2 and L. D. LehmanMcKeeman1. 1Bristol Myers Squibb, Princeton, NJ,
2
KS and 3Genentech, South San Francisco, CA.
#2148
HYPOXIA POTENTIATES
HEPATOCELLULAR KILLING BY
NEUTROPHIL MEDIATORS IN VITRO. P. J.
Shaw1, 2, 3, J. P. Luyendyk1, 2, 3, P. E. Ganey1, 2, 3 and R.
A. Roth1, 2, 3. 1Pharmacology & Toxicology, Michigan
State University, East Lansing, MI, 2National
Food Safety & Toxicology Center, Michigan State
East Lansing, MI.
#2149
PREDICTION OF METABOLIC CLEARANCE
OF BISPHENOL A USING CRYOPRESERVED
HUMAN HEPATOCYTES. R. Kuester and G.
Sipes. Pharmacology, The University of Arizona,
Tucson, AZ.
#2150
INVESTIGATION OF BIOLOGICAL
MEDIATORS DERIVED FROM ACTIVATED
RAT LIVER CELL MIXTURE USING
MOLECULAR APPROACHES. R. Hu, S. Taylor,
D. Wen, S. Patterson, M. Davis, M. Hayashi, M.
Damore, P. McDonagh and C. Afshari. Amgen Inc.,
Thousand Oaks, CA.
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: CARDIOVASCULAR SYSTEM:
CARDIOTOXICITY
Chairperson(s): Richard Peterson, University of Wisconsin Madison,
Madison, WI and Phil Kopf, University of New Mexico, Albuquerque, NM.
OVEREXPRESSION OF CALPASTATIN
IN HEPATOCYTES PROLIFERATING IN
CULTURE MAKES THEM RESILIENT TO
CALPAIN-MEDIATED INJURY. V. S. Bhave, S.
Donthamsetty and H. M. Mehendale. Toxicology,
University of Louisiana at Monroe, Monroe, LA.
NONALCOHOLIC STEATOHEPATITIS
(NASH): MECHANISMS OF HEPATOTOXIC
SENSITIVITY. S. Donthamsetty1, V. Bhave1,
M. Mitra1, J. Latendresse2 and H. Mehendale1.
1
university of louisiana, monroe, LA and 2NCTR,
jefferson, AR.
#2147
231
#2151
ERBB2 PROTEIN IS INCREASED IN
DOXORUBICIN CARDIAC TOXICITY. K. L.
Gabrielson, N. Muratore, S. Pin, L. Wachtman and
D. Bedja. Comparative Medicine, Johns Hopkins
#2152
COPPER SUPPLEMENTATION INHIBITS
AORTIC BANDING-INDUCED HEART
HYPERTROPHY IN A MOUSE MODEL.
C. L. Reynolds1, Y. Jiang2, W. Rodriguez1, K.
Merten2, X. Sun2 and Y. Kang3, 2, 1. 1Physiology/
Biophysics, University of Louisville, Louisville, KY,
2
Pharmacology/Toxicology, University of Louisville,
Louisville, KY and 3Medicine, University of
WEDNESDAY
#2140
45th Annual
Meeting & ToxExpo
#2153
#2154
#2155
A STUDY INVESTIGATING SERUM
TROPONIN LEVELS IN ISOPROTERENOLINDUCED CARDIOMYOCYTE INJURY. S.
Brady1, M. York2, C. Scudamore3, S. Jamalfar1, I.
Roman2, C. Stamp2, A. Swain2, T. Williams2, W.
Griffiths1 and J. Turton1. 1School of Pharmacy,
London, United Kingdom, 2GlaxoSmithKline,
Ware, Hertfordshire, United Kingdom and 3Covance
Laboratories Ltd., Harrogate, North Yorkshire,
United Kingdom. Sponsor: J. Ferguson.
AHR2 AND ARNT1 MEDIATE THE CARDIAC
TOXICITY OF TCDD IN EMBRYONIC
ZEBRAFISH. D. S. Antkiewicz1, R. E. Peterson2
and W. Heideman2. 1Molecular and Environmental
Toxicology Center, University of Wisconsin,
Madison, WI and 2School of Pharmacy, University
of Wisconsin, Madison, WI.
#2161
THE EFFECT OF CGP12177 ON THE
CARDIOVASCULAR SYSTEM IN NONHUMAN PRIMATES, AS NEW CONCEPT OF
β3-ADRENOCEPTOR. Y. Torikai, H. Magotani,
A. Suzuki, T. Shigeyama, H. Yonamine, M. Hijioka,
K. Kuwano, K. Fukuzaki, R. Nagata and G. Kito.
Drug Safety Research Laboratories, Shin Nippon
Biomedical Laboratories, Ltd (SNBL), kagoshima,
Japan.
INDUCTION OF MITOCHONDRIAL TRNA
GENE MUTATIONS IN HIV-NEGATIVE
CHILDREN EXPOSED IN UTERO TO AZT3TC. D. Cook, J. Meng, S. Torres, M. Carter,
D. Walker and V. Walker. Lovelace Respiratory
Research Institute, Albuquerque, NM.
#2162
NUCLEOSIDE REVERSE TRANSCRIPTASE
INHIBITORS (NRTI) INHIBIT CAMPDEPENDANT PHOSPHOREGULATION OF
COMPLEX I IN RAT HEART. K. C. Lund and K.
B. Wallace. Biochemistry and Molecular Biology,
Toxicology Graduate Program, University of
Minnesota Medical School, Duluth, MN.
METABOLIFE AND ITS CONSTITUENTS
INCREASE ATYPICAL CARDIAC CELLS, AN
EFFECT EXACERBATED BY NICOTINE. A.
A. Grippo1, C. E. Brown1, S. Trauth1, R. S. Grippo1
and B. J. Gurley2. 1Biological Sciences, Arkansas
State University, State University, AR and 2College
of Pharmacy, University of Arkansas for Medical
Sciences, Little Rock, AR. Sponsor: D. Schlenk.
#2163
ALDH2 AND GTN BIOACTIVATION TO NO. I.
Kastrati and G. R. Thatcher. Medicinal Chemistry,
University of IL at Chicago, Chicago, IL.
#2164
TCDD STIMULATES L-TYPE CA2+ CURRENT
VIA A PROTEIN KINASE C SIGNALING
PATHWAY IN GUINEA PIG VENTRICULAR
MYOCYTES. D. Wang1, A. Xie3 and N. Walker2.
1
College of Pharmacy, University of South Carolina,
Columbia, SC, 2NIEHS, Research Triangle Park, NC
and 3University of Chicago, Chicago, IL.
#2165
BIOMARKERS OF ISOPROTERENOLINDUCED CARDIAC DAMAGE. T. P. O’Neill1,
P. Tarantino2, C. P. Chengelis1, M. Herberth1 and M.
Lee2. 1WIL Research Laboratories LLC, Ashland,
OH and 2Sepracor Inc., Marlborough, MA.
#2166
TIMECOURSE ANALYSIS OF THE INTRARENAL AORTIC BANDING–INDUCED LEFT
VENTRICULAR HYPERTROPHY IN MICE. H.
Higashiyama, H. Inoue, M. Sugai, H. Kushida, M.
Kinoshita and S. Asano. Pharmacology Department,
GlaxoSmithKline, Tsukuba Research laboratories,
Ibaraki, Japan.
#2167
ECTOPIC EPITHELIAL STRUCTURES IN
THE HEART OF CYNOMOLGUS MONKEY
(MACACA FASCICULARIS). J. Kaspareit, S.
Friderichs-Gromoll, E. Buse and G. Habermann.
Covance Laboratories GmbH, Muenster, Germany.
Sponsor: F. Vogel.
#2168
DOSE-RESPONSE-BASED, MYOCARDIAL
AND CORONARY ARTERIAL INJURY
SEPARATION DUE TO POTASSIUM
CHANNEL OPENER ZD6169. H. B. Jones1, S.
Gould1, C. Louden1, J. Schofield1 and D. Brott2.
1
safety assessment, astrazeneca pharmaceuticals,
MACCLESFIELD, United Kingdom and 2Safety
Assessment, Astrazeneca Pharmaceuticals,
WILMINGTON, DE.
#2156
METALLOTHIONEIN PREVENTS
ANGIOTENSIN-INDUCED CARDIAC CELL
DEATH THROUGH SUPPRESSION OF
NADPH OXIDASE ACTIVATION. G. Zhou,
Y. Kang and L. Cai. University of Louisville,
Louisville, KY.
#2157
UPREGULATED STAT3, HIGHER
CATALASE, AND ENERGY LEVELS
PROTECT DIET-RESTRICTED RATS
FROM DOXORUBICIN-INDUCED
CARDIOTOXICITY. M. S. Mitra1, S.
Donthamsetty1, J. R. Latendresse2 and H. M.
Mehendale1. 1University of Louisiana at Monroe,
Monroe, LA and 2NCTR, Jefferson, AR.
#2158
#2159
WEDNESDAY
#2160
BIOENERGETIC PHENOTYPE OF
NRTI-INDUCED MITOCHONDRIAL
CARDIOMYOPATHY. A. P. Rolo, L. Peterson,
J. A. Bjork, J. Berthiaume and K. B. Wallace.
Department of Biochemistry & Molecular Biology,
University of Minnesota Medical School, Duluth,
MN.
ZINC PRETREATMENT PROTECTION
AGAINST DOXORUBICIN-INDUCED
CARDIOTOXICITY DEPENDS ON THE
LEVELS OF CARDIAC METALLOTHIONEIN.
S. Peng1, 2, J. Guo1, 2, M. Liu1, 2, C. Yan1, 2, H. Yang1, 2
and G. Wang1, 2. 1Beijing Institute of Pharmacology
and Toxicology, Beijing, China and 2National
Beijing Center for Drug Safety Evaluation and
Research, Beijing, China.
232
45th Annual
Meeting & ToxExpo
SPECIES DIFFERENCES IN
CARDIOVASCULAR EFFECTS FOLLOWING
INTRAVENOUS ADMINISTRATION OF
COCAINE AND METHAMPHETAMINE IN
TELEMETERIZED BEAGLE DOGS AND
CYNOMOLGUS MONKEYS. M. P. Benson, J. A.
Dalton, J. R. May and P. E. Newton. MPI Research,
Mattawan, MI.
#2170
2, 3, 7, 8-TETRACHLORODIBENZO-PDIOXIN (TCDD) EXPOSURE DURING FETAL
DEVELOPMENT PREDISPOSES MALE
OFFSPRING TO CARDIAC DYSFUNCTION
IN ADULTHOOD. A. C. Aragon1, P. G. Kopf1, B.
Goens2 and M. K. Walker1. 1College of Pharmacy,
University of New Mexico, Albuquerque, NM and
2
Pediatrics, University of New Mexico School of
Medicine, Albuquerque, NM.
#2171
SUB-CHRONIC, LOW LEVEL EXPOSURE
OF ADULT MALE MICE TO 2, 3, 7, 8TETRACHLORODIBENZO-P-DIOXIN (TCDD)
INDUCES OBESITY AND HYPERTENSION.
P. G. Kopf, A. K. Lund and M. K. Walker. College of
Pharmacy, University of New Mexico, Albuquerque,
NM.
#2172
TRANSCRIPTIONAL RESPONSE TO 2, 3, 7,
8-TETRACHLORODIBENZO-P-DIOXIN IN
ZEBRAFISH LARVA HEARTS. S. A. Carney1, J.
Chen1, C. Burns2, 3, K. M. Xiong1, R. E. Peterson1
and W. Heideman1. 1University of Wisconsin,
Madison, WI, 2Massachusetts General Hospital,
Charlestown, MA and 3Harvard Medical School,
Boston, MA.
#2173
#2174
#2175
DIFFERENCES IN CARDIOVASCULAR
RESPONSE TO PM EXPOSURE BETWEEN
SPONTANEOUSLY HYPERTENSIVE
STROKE-PRONE (SHSP) AND WISTARKYOTO (WKY) RATS. A. P. Carll1, W. H. Rowan2,
J. Wallenborn3, D. W. Winsett2, M. Schladweiler2,
L. B. Wichers3, D. L. Costa2, Universtiy of. P.
Kodavanti2 and W. P. Watkinson2. 1Student Contractor
ORD/NHEERL/ETD/PTB, U.S. EPA, Research
Triangle Park, NC, 2ORD/NHEERL/ETD/PTB,
3
Environmental Sciences and Engineering, UNC
School of Public Health, Chapel Hill, NC.
CARDIOVASCULAR SAFETY
PHARMACOLOGY EVALUATIONS DURING
EXERCISE STRESS IN DOGS. C. R. Hassler1,
M. Coffee1, M. Ellinger1, M. Hawk1, R. Lordo1, M.
Stonerook1, T. Vinci1, B. Wood1 and R. Hamlin2.
1
Battelle, Columbus, OH and 2The Ohio State
University, Columbus, OH. Sponsor: M. Hejtmancik.
#2177
CARDIOVASCULAR SAFETY
PHARMACOLOGY EVALUATION IN NONHUMAN PRIMATES: COMPARISON OF
CONSCIOUS AND UNCONSCIOUS MODELS.
M. Ouellet1, 2, S. Authier1, 2, A. Nelson1 and A.
Abedian1. 1LAB. Preclinical Research, Laval,
QC, Canada and 2School of Veterinary Medicine,
University of Montréal, St-Hyacinthe, QC, Canada.
Sponsor: I. Dean.
#2178
KNOWLEDGE OF CARDIOVASCULAR
RISK FACTORS IN KOSOVO: A STUDENT
PROJECT. J. M. Donohue1, A. Cocaj2, O. Gjergji3,
T. Kalefi3, M. Kashari4 and Q. Sinanaj2. 1Health and
Ecological Criteria Division, U.S. EPA, Washington,
DC, 2Biology, University of Pristina, Pristina,
Kosovo, Yugoslavia, 3Medicine, University of Tirana,
Tirana, Albania and 4Natural Sciences, University of
Tirana, Tirana, Albania. Sponsor: E. Ohanian.
#2179
DIFFUSION AND PERCEPTION OF
MERCURY RISK INFORMATION. D. D.
Petersen1, 2. 1Research & Development, U.S. EPA,
Cincinnati, OH and 2Biology and Horticulture,
Wednesday, March 8
1:30 PM to 4:30 PM
Exhibit Hall
POSTER SESSION: RISK ASSESSMENT—METALS
Chairperson(s): Lisa Yost, Exponent, Bellevue, WA.
ULTRASONIC ANALYSIS, A TOOL FOR
EARLY DETECTION OF CARDIOTOXIC
LESIONS: PRELIMINARY FINDINGS. J.
Dunnick1, D. Rouse2, P. Myers2, C. Vanderklok3,
A. Nyska3, J. Johnson3, J. Horton3, W. Lieuallen4,
D. Malarkey3, R. R. Maronpot3 and K. Johnson3.
1
Toxicology Operations Branch, NIEHS/NIH/
DHHS, Research Triangle Park, NC, 2Comparative
Medicine Branch, NIEHS/NIH/DHHS, Research
Triangle Park, NC, 3Laboratory of Experimental
Pathology, NIEHS/NIH/DHHS, Research Triangle
Park, NC and 4Pathology Associates International,
Cary, NC.
INHALATION OF FINE PARTICLES
MODIFIES CARDIOVASCULAR FUNCTION
IN AGED RATS. M. T. Kleinman, A. Hamade and
D. Meacher. Community and Env. Med., University
California, Irvine, Irvine, CA.
#2176
233
#2180
IMPLICATIONS OF CHANGES IN THE
ARSENIC CANCER SLOPE FACTOR FOR
RISK COMMUNICATION. L. Yost1, J. S. Tsuji2,
C. G. Scrafford3, L. M. Barraj3 and P. J. Mink3.
1
Exponent, Saint Paul, MN, 2Exponent, Bellevue,
WA and 3Exponent, Washington, DC.
#2181
DEVELOPING RECOMMENDED EXPOSURE
LEVELS FOR AIRBORNE ARSENIC. M. Seeley
and T. S. Bowers. Gradient Corporation, Cambridge,
MA.
#2182
INTEGRATION OF THE AVAILABLE
GENOMIC DATA FOR INORGANIC ARSENIC
SPECIES TO SUPPORT THE DEVELOPMENT
OF A NONLINEAR CANCER DOSERESPONSE MODELING APPROACH. P. R.
Gentry1, T. McDonald1, D. Sullivan1, J. Yager2, K. S.
Crump1 and H. J. Clewell3. 1ENVIRON International
Corp., Ruston, LA, 2EPRI, Palo Alto, CA and 3CIIT,
WEDNESDAY
#2169
45th Annual
Meeting & ToxExpo
#2183
IS INORGANIC ARSENIC A CANCER RISK
AT LOW DOSES? K. G. Brown. KBinc, Chapel
Hill, NC. Sponsor: J. Tsuji.
#2184
META-ANALYSIS OF

Annual Meeting Program - Society of Toxicology

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