presentation - Partnering For Cures

Identifying Experts:
Enlight Biosciences &
AstraZeneca launch KNODE
Baruch Harris, PhD
Chief Business Officer, Enlight Biosciences
David Tharp
Head of Business Development, KNODE, Inc.
Enlight Biosciences Pharma Syndicate
Developing Transformational Technologies
Abbott
Merck
Abbott
Pfizer
Lilly
Novo
Nordisk
NewCo 1
NewCo 2
J&J
NewCo 3
NewCo …
Transforming BioPharma R&D
Unmet Need
• Decreased funding for platform technologies
• Sub-optimal communication between entrepreneurs and pharma
• Opportunities for collaborative investment / development
Structure &
Mission
• Top tier pharma companies, innovators, entrepreneurs working together
• Partner to develop and commercialize – goal is to transform pharma R&D
Pharma
Member Role
• Inform areas of focus, guide development of science and technologies to
meet critical needs
• Invest in portfolio companies, ‘first-line’ strategic partners
FOCUS AREAS :
Clinically
Relevant Targets
Platforms for
Customized
Treatments
Drug Safety
Systems Biology
Delivery
New Chemistries
or Therapeutic
Modalities
How We Work:
Collaborative Venture Creation
Pharma Partners
Academic / Entrepreneur Network
Abbott
Merck
Abbott
Pfizer
Lilly
Novo
Nordisk
•
•
•
J&J
Identify critical needs & gaps
Invest and participate in NewCo
Balance near term value and long term
transformational impact
•
•
•
Maintain close relationships with
academic experts
Ensure scientific rigor
Access cutting edge technology
Collaboratively commercializing innovative technologies for drug discovery and development
PureTech & Enlight Leadership:
Translating Innovation
Bennett
Shapiro, MD
John
LaMattina,
PhD
Robert
Langer, ScD
Ron
Cape, PhD
John
Zabriskie,
PhD
Former EVP
Former President
of Global R&D
Institute CoProf. Founder
Former
CEO
Former
Pres.
Former CEO
Raju
Kucherlapati,
PhD
Founder Professor
Daphne
Zohar
PureTech Founder
Eric Elenko,
PhD
Former roles
Professor
Rakesh Jain,
PhD
Sanjiv
Gambhir, MD,
PhD
H. Robert
Horvitz, PhD
Frederick
Frank
Professor
Nobel
Laureate Professor
David
Steinberg
Former roles
Stephen
Muniz, JD
Former Partner
Vice Chairman
Baruch
Harris, PhD
Former roles
Key Benefits of Enlight Membership
• Immediate access to unmatched network of experts &
leading thinkers in healthcare space
• Equity ownership, strategic rights in NewCos
• Access to technology diligence database (2-250
opportunities / year)
• Focused sourcing / NewCo creation initiatives
• Integration into unique syndicate of innovative
pharmaceutical companies and academic entrepreneurs
KNODE is the latest portfolio company in
Enlight Biosciences pharma syndicate
Abbott
Merck
Abbott
Pfizer
Lilly
Novo
Nordisk
Endra
Entrega
J&J
NewCo 4
KNODE addresses challenge of identifying
top internal & external technical expertise
Key trends shaping the medical R&D landscape:
• Companies externalizing more & more ‘R’
• Universities looking to fill funding gaps
• Patient groups seen as active collaborators
KNODE
allows users to instantly:
• Identify top established & emerging researchers
• Assemble expert, cross-disciplinary project teams
Integrating high quality, expert scientific content
is the foundation of the KNODE platform
Aggregation
Automation
Access
Combines internal, external
data; crowd source feedback
Creates researcher expertise
profiles automatically
Open access with integration
across many destinations
Current Sources
Custom Sources
Proprietary Data
Web portals,
Microsoft SharePoint,
Research networking,
CRM Systems,
R&D directories
Enterprise social platforms,
and many more.…
KNODE’s platform automatically aggregates
scientific content into expertise profiles
Full scientific
content summary
Expertise tag cloud
via KNODE’s semantic
processing facilitates
search
Users can claim,
edit, & augment
their profile
Expert content relevant to
user search is automatically
returned & tabulated
As an Enlight partner, AstraZeneca will
collaborate on the development of KNODE
“…we expect KNODE will provide an efficient platform to access and mine a broad
range of data to
identify expert sources
relationships that provide our R&D scientists
across topics and
unique insight
into
emerging science and opportunities.” John Reynders, VP R&D Information
Companies & other research organizations can
enhance interactions with external experts
Quickly and easily track areas & people
of interest over time, worldwide
Technology licensing
& business
development
R&D
Collaborations
Research grants &
Open Innovation
Initiatives
*Screenshots are for example only
~6M expert profiles
Organization portals direct searches to
a sub-set of the full KNODE ecosystem
Portals promote researcher expertise & their content
on webpages, intranet sites, & conferences
search.knodeinc.com/louisville
Search
UofL Faculty,
Staff,
Clinicians, &
Researchers
Leverage internal knowledge &
collaborations for innovation initiatives
2
1
Internal Innovation
Initiative Topic
Matched with most
relevant internal
experts worldwide
Faster, higher quality
diligence & feedback
on initiative
Link to KNODE on home
or intranet page to search
internally, or across the
entire KNODE System
3
Integrate with
research workspaces
to share data & launch
new project teams
KNODE is changing R&D collaboration:
“…its who you don’t know”
A powerful platform for aggregating
content & identifying expertise…
…now a solution for accessing expert
scientific innovation & research
~6M expert profiles via
>14.5M pieces scientific content
Broad use by life sciences &
other co’s around complex
tasks, projects, & topics
Contact Information & Discussion
Contact:
Baruch Harris, PhD
Chief Business Officer
Enlight Biosciences
E: [email protected]
Contact:
David C. Tharp
Head of Business Development
KNODE, Inc.
E: [email protected]