Challenges facing 21st Century Health Care Delivery in the UK

Solving public sector problems
SBRI – a case study led by the Eastern AHSN
March 2015
Academic Health Science
Networks
“Other actions require new
partnerships with local
communities, local
authorities and employers.”
Academia
Business
Clinician
NHS service
Accelerating Innovation
Small Business Research
Initiative – SBRI Healthcare
Accelerating Innovation
Myth – how Science &
technology businesses start up
12
10
8
Define product
idea
6
4
2
Write the
business plan
Raise venture
capital
Develop and
market product
0
-2
-4
-6
-8
Accelerating Innovation
1
2
3
4
5
6
7
8
9
10
11
12
© David Connell
University of
Cambridge
The evidence base –
start up models in Cambridge
• One of Europe’s leading science and
technology clusters
• University has had 88 Nobel Prize
winners – more than any other
university in the world
• Other research labs include – Microsoft,
Intel, Hitachi, Toshiba, Rolls Royce,
Pfizer, GSK, Unilever, Philips GSK and
the Wellcome Trust Sanger Institute
• 1400 hi-tech firms; 53,000 employees
Accelerating Innovation
© David Connell
University of
Cambridge
The alternative ‘ soft start
up’
12
CUMULATIVE
CASH FLOW
10
MYTH 1: VC funding is the
successful model
8
6
4
2
YEARS
MYTH 2: Academic IP is the
key source of ideas
0
-2
1
2
3
4
-4
-6
-8
$m MANY
5
6
7
8
9
10
11
12
Myth 3 - Government
stimulate innovation by cofunding multi-partner
collaborative R&D projects
THE KEY DRIVER OF INNOVATION IS SOLVING CUSTOMER
© David Connell
PROBLEMS THOUGH R&D CONTRACTS
University of
Cambridge
Accelerating Innovation
The US Government – ‘procurement based’ innovation
policies
• DARPA - $3 billion per annum
• Small Business Innovation Research
(SBIR)- $2.5 billion per annum :
• $150k for Phase I
• $1m for Phase II
• Contracts: 100% funded -up-front
• Companies get IP
© David Connell
University of
Cambridge
Accelerating Innovation
UK SBRI key features
 Helping the Public Sector address
challenges
• Using innovation to achieve a
step change
 Accelerating technology
commercialisation
• Providing a route to market
 Support and the development of
Innovative companies
• Providing a lead customer/R&D
partner
• Providing funding and credibility
for fund raising
•
•
•
 100% funded R&D
 Operate under procurement rules
rather than state aid rules
 UK implementation of EU PreCommercial Procurement
 Deliverable based rather than
hours worked or costs incurred
Contract with Prime Supplier
 Who may choose to sub contract
but remains accountable
IP rests with Supplier
 Certain usage rights with Public
Sector – Companies encouraged
to exploit IP
Light touch Reporting & payments
quarterly & up front
www.sbrihealthcare.co.uk
Accelerating Innovation
Competition process
Typically
undertaken by
clinicians –
service driven
Problem
Identification
Workshops with
industry to support
understanding
Open call to
Industry
Typically 6
months – max
of £100k
Feasibility
Testing
Due diligence & contracts
www.sbrihealthcare.co.uk
Accelerating Innovation
Typically 18 months
– milestones agreed
& monitored
Prototype
development
Case study:
Diabetes is the most common cause of preventable adult blindness
in the developed world. Treating it costs the NHS about £1bn a
year. Currently treatment costs of as much as £10,000 per patient
for each eye.
The PolyPhotonix bio-photonic research and development company
has developed a light therapy sleep mask costs £250 for 12 weeks’
treatment
Trials have shown that eye disease can be reversed with significant
results after as little as six months. Approximately 30 clinics around
the country are trialling the product including Moorfields eye
hospital. It is anticipated that Noctura 400 will receive NICE
approval by the end of 2015.
•
“There is no contest that I would
choose the mask over the laser
treatment. It is easy to use and
removes any traumatic
experience that occurred when
having my eyes lasered.”
£1,458,158 awarded
Estimated savings at £1 billion per annum
Product available now
60 employees directly created as a result of SBRI funding.
Approximately £2 million of additional investment has also been secured by the company.
Accelerating Innovation
Case study:
An estimated 5.3 million people suffer from chronic pain in England which has a major
impact on sufferers’ lives, with 24% reporting a diagnosis of depression and 26%
reporting an impact on employment.
Self-help digital products to support people with chronic pain. The technology will
enable both patient and practitioner to have a balanced step-wise process to selfassess, self-manage, and self-monitor changes in pain.
Pathways through Chronic Pain is being developed as a cost-effective Cognitive
Behavioural Therapy (CBT)-based pain management programme without the need for
direct involvement by a therapist or clinician.
“As a pain specialist
physiotherapist familiar with
the pain plan I think this app is
excellent. I have set goals and
goal alerts and look forward to
being reminded about them. It
is easy to use so far.”
“One of things I really loved about it was that I got quite
poorly for a few days and I started struggling with my
activity goals, and kept recording ‘I struggled, I struggled’.
After a couple of times the app flashed up and said ‘are you
sure this goal isn’t too high for you – do you want to adjust
your goal’. I thought this is brilliant and so I changed it and
started meeting it again and that was so much better than
keeping failing.”
£885,970.00 awarded
Estimated savings to NHS at £20 million per annum – 4 jobs created currently
Product available: summer 2015
Accelerating Innovation
Case study:
Mental health problems affect one in four people and this is
rising. The economic and social costs of mental health problems
are also increasing; they were estimated to be over £100bn in
2010, an increase of 36% over the period 2003-101.
ProReal gives people a tool to create a visual representation of
their world, or a specific situation, and then explain it to others.
This interactive landscape can be viewed from their perspective
or that of any other individuals represented there. This can be
used to clarify understanding, share ideas, identify problems and
consider options for change and development.
Currently in use with HM Prison Service – early evidence shows
they are reaching this hard to access community. ProReal have
been funded to take this intervention into young people services
“After many years of work in the
field of remote and online
coaching, I think the ProReal
toolset has the potential to
radically improve how this is
done. I’m very excited to be part
of the team steering its
development.”
£1,069,870 awarded
Products available now
Estimated savings – not possible to show as yet
Building evidence of improved outcomes with no additional cost
Accelerating Innovation
Ideas delivered - outcomes
NHS funded, AHSN led programme, with national clinical and industry engagement and the potential to deliver substantial NHS
efficiency saving and health benefits
£35m
invested
since 2012
138 contracts
24 clinically
led
challenges
during annual
cycle of 2
challenges
7m patients
helped
93 feasibility
contracts (phase 1)
Total Possible Annual Savings, £434m**
37 development
contracts (phase 2)
8 implementation
contracts (phase 3)
£1.5bn in
efficiency savings*
Economic dividends & targets
60
50
40
30
20
10
0
57
Turnover
Company Size
40
30
28
20
5
7
10
0
Company Status
33
36
40
21
15
30
19
8
20
25
19
17
10
0
Start-Up 1-5 yrs 5-10 yrs >10 yrs
Accelerating Innovation
150 jobs, 31
patents/TMs,
£10m+
VC/investor
funds
leveraged
[email protected]
March 2015