2012 Annual Report

Transcription

2012 Annual Report

ARMI Stakeholders
Extending internationally
01 01 12
04
31 12 12
ARMI Annual Report 2012
Acknowledgements
Australian Regenerative Medicine Institute
2012 Annual Report
editorial team
laura Crilley
Silvio tiziani
Melissa trudinger, Science in Public
Margie Beilharz, Science in Public
design
linda Cerkvenik, outsource Design
photography
David Russell, David Russell Photography
Printed on 100% recycled paper
trademark – Australian Regenerative Medicine
Institute 2012
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ARMI AnnuAl RePoRt 2012
Contents
Introduction
Director’s Report
About the Australian Regenerative Medicine Institute (ARMI)
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3
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Research
2012 Highlights
Appointments
ARMI Scientific Retreat
eMBl Australia
SBI Australia
Rosenthal Group
Currie Group
Barberi Group
Bourne Group
Heng Group
Hobbs Group
Kaslin Group
lieschke Group
Marcelle Group
McGlinn Group
Plachta Group
Polo Group
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Core Research Facilities
FishCore
Gene Recombineering
eS Cell Genetics Services
ARMIRat
FlowCore
Micromon
Monash Micro Imaging
Structural Biology
Monash Gene targeting Facility
Monash Antibody technologies Facility
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Governance
Committees
ARMI team
nationalities
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Financials
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Activities
Visitors
events
ARMI in the news
external Seminar Series
Internal Seminar Series
Research Activities
BioeYeS outreach Program
Publications
How to donate to ARMI
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Introduction
“
Looking outwards,
strong national
and international
linkages are a
key strategy for
continuing to improve
our scientific
outputs.
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Director’s Report
I am pLeased to report that 2012 has been another year of successfuL
growth and deveLopment for the austraLIan regeneratIve medIcIne
InstItute (armI).
Highlights from our fourth year of operation include
the ARMI Scientific Retreat, held at Silverwater
Resort near Phillip Island, which gave our research
staff the opportunity to review and discuss their
research programs with their peers. We were
delighted that Professor Peter Rigby and Professor
Dame Kay Davies, both eminent members of
our newly established Scientific Advisory Board,
attended the retreat and welcomed the feedback
and recommendations they generously provided.
our Institute grew by almost 50% with the addition
of new postdocs, PhD and undergraduate students
and technical staff. At the end of 2012 we had 12
research groups.
two key indicators of successful research are
the number of grants awarded to support the
continuation of the research and number of
research papers published. on both of these
indicators, the Institute has had a successful year.
twelve out of 32 grant applications submitted to
the national Health and Medical Research Council
(nHMRC) and the Australian Research Council
(ARC) were successful. this 38% success rate is
well above the national average of around 20%.
In 2012, ARMI scientists published almost double
their 2011 output, an indication that our research
programs are maturing. It was exciting to see that
the number of papers published in high impact
journals including Cell and Science also increased
significantly.
We have also recognised one of our group leaders,
James Bourne, for his outstanding achievements
both as a researcher and also through his efforts to
develop our accredited Higher Degree by Research
(HDR) program by promoting him to Associate
Professor.
nanotechnology in Queensland is an internationally
renowned expert in bioengineering tissue scaffolds
and smart surfaces, and his appointment will add
a new dimension to our regeneration research.
Professor Stewart, at BioInnovationsZentrum,
technische universitaet Dresden in Germany, has
played a role in developing many of the recombinant
DnA technologies we use at ARMI and has recently
begun to focus on systems biology. We welcome
them both to ARMI and hope their visits prove
fruitful for all of us.
eMBl Australia, which is headquartered here
at ARMI, is continuing to grow and develop its
programs, with the launch this year of a suite of
student travel grants and programs, and plans for
a new node at the new South Australian Health and
Medical Research Institute well underway.
our newest initiative is SBI Australia, the first
international node of Japan’s Systems Biology
Institute. SBI Director, Hiroaki Kitano, was
appointed Sir louis Matheson Distinguished Visiting
Professor at Monash university last year, with
an adjunct appointment at ARMI, and is already
collaborating with several groups here. With our
new links through SBI Australia, we are looking
forward to a long and fruitful association with SBI.
through SBI Australia and our close association
with eMBl Australia, we are showcasing Australia’s
life sciences research to the world.
All of our successes over the last year would not
have been possible without the hard work of our
ARMI research teams, staff and students. In the
coming year, our focus will be on strategic planning
to maintain our trajectory for sustained leadership
in the global regenerative medicine landscape.
our student programs have continued to expand,
with 11 students enrolled in higher degrees and six
in Honours. And all six PhD students from our first
HDR cohort achieved candidature in 2012.
looking outwards, strong national and international
linkages are a key strategy for continuing to
improve our scientific outputs. In 2012 we appointed
two new adjunct professors: Justin Cooper-White
and Francis Stewart. Professor Cooper-White at
the Australian Institute for Bioengineering and
Professor Nadia Rosenthal
Founding Director
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Introduction
About the Australian Regenerative
Medicine Institute (ARMI)
Central to ARMI is the attraction and development
of future scientific leaders, recruited through the
EMBL Australia Group Leader pipeline. These
young researchers of high potential are provided
guaranteed research funding for a defined period
to accelerate their careers and nurture their talent.
Expert mentoring, combined with state-of-the-art
core research infrastructure and facilities, provides
a rich and inspirational research environment.
The practice of Group Leaders moving on to other
institutes after a flying start enhances ARMI’s
flexibility and disseminates this dynamic research
culture to other institutions.
Through a joint venture
between Monash University, the
Government of Victoria and the
Federal Government, ARMI has
been established as a state-ofthe-art regenerative medicine
research facility at the Clayton
campus of Monash University
in Melbourne. Building on the
University’s existing strengths in
biomedical and stem cell research,
critical infrastructure (including
laboratories and core equipment)
has been assembled to deliver
the next generation of research
outcomes in regenerative medicine.
Australia’s first regenerative
medicine research centre is
a timely response to capture
new opportunities in a rapidly
expanding sector of biomedical
research. The Institute boasts a
cross-disciplinary, highly focused
approach to the science of
regeneration, designed to seed and
foster collaboration, and to pursue
rapid translation of basic research
into clinical treatments.
ARMI scientists are devoted to addressing
questions in regenerative biology that provide
the knowledge base to move beyond current
therapies into combination therapy paradigms.
The Institute’s Faculty members, recruited from
around the world, represent a broad range of
disciplines that contribute to a shared vision for the
development of regenerative therapies, capturing
new opportunities for international collaboration.
The functional integration of key research platforms
at each level of enquiry—molecular genetics, stem
cell biology, and animal modelling—aims to deliver
technologies with medium-to-long term application
for treatment of diseases of social, medical and
economic importance to Australia; and promises to
redefine how regenerative medicine is approached
worldwide.
ARMI could not have been established without
significant financial contributions from both
Monash University and government. Monash
University’s capital investment of $103 million
for the construction and fit-out of new state-ofthe-art laboratory facilities was augmented by a
contribution of $50 million from the Victorian and
Federal Government for additional ARMI laboratory
fit-out and the acquisition of critical research
equipment. The capital cost of the $100 million
ARMI project included provision for the construction
of the nearby Buildings 76 and 77 to house the
research laboratories of the Faculty of Medicine’s
School of Biomedical Sciences.
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vision
themes
the Australian Regenerative Medicine Institute at
Monash university is a globally oriented research
organisation committed to discoveries and
therapeutic strategies that lead to restoring health
and normal function, repairing damaged tissues
and regenerating the ageing body.
Regenerative Medicine: Regenerative Medicine
seeks to repair, replace, restore and regenerate
tissues and organs damaged by age, injury, and
genetic and degenerative conditions. It represents
a revolution in human health, and has the potential
to reverse tissue damage, repair traumatic injuries
and improve the health of an ageing population.
mission
Outstanding Science: ARMI actively recruits young,
creative scientists from all corners of the world,
to share and inspire differing approaches to some
of the most perplexing biological questions of our
time. they are highly motivated, nurtured in a
collaborative working environment and approach
complex biological problems with ingenuity and
passion.
ARMI’s mission is to:
• promote Australia as a global leader in
regenerative medicine and assist Melbourne to
become one of five major biotechnology centres
in the world
• foster and develop an ethos of collaboration
across Melbourne to link areas of existing
excellence and accelerate clinical results
• enhance research excellence by building
linkages with research users and providers
against the backdrop of Monash stem cell
science and biomedical research, enhancing
international collaborative endeavours
• contribute to undergraduate teaching programs
and establish a major site for postgraduate
training.
Internationalism: ARMI’s standing as secretariat
and headquarters of the esteemed european
Molecular Biology laboratory (eMBl) Australia
makes the Institute a portal to the global
international community; providing researchers
unique access to the best science in europe and
a new way of approaching scientific endeavour.
SBI Australia, the first international node of the
renowned Systems Biology Institute in Japan, is
also being hosted by ARMI and provides valuable
links to Japan.
Research Ecosystem: As a global biotech life
science centre situated at Monash university, ARMI
is an integral presence in the broader Melbourne
research and medical ecosystem. Its state-ofthe-art core scientific facilities are maintained by
outstanding infrastructure and technology.
Community: ARMI is a significant part of the fabric
of Melbourne through its outreach programs and
engagement with community.
Passport: Working side by side with research
groups from eMBl Australia enriches scientific
development and fosters new international
research collaboration.
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RESEARCH
“
Our Institute grew
by almost 50% with
the addition of new
postdocs, PhD and
undergraduate
students and
technical staff. At the
end of 2012 we had 12
research groups.
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2012 Highlights
• At 31 December 2012, ARMI has 146 people,
comprising researchers, students, affiliates,
core facility support and administrative
personnel.
Australian Institute of Bioengineering and
nanotechnology and Professor Francis Stewart
from the BioInnovationsZentrum, technische
universitaet Dresden, Germany.
• ARMI’s grant application success rate of 38% for
the year was higher than the national average
of just over 20%. total income from grants was
more than $4.8 million, an increase of 18% over
the previous year.
• ARMI’s international linkages were further
strengthened by the Systems Biology Institute’s
decision to open its first international node
at Monash university. SBI Australia is hosted
at ARMI.
• ARMI researchers published 53 papers (up from
26 in 2011) as well as four book chapters and
one book. Highlights include papers in the high
impact journals Cell and Science.
• the Institute held a scientific retreat at
Silverwater Resort near Phillip Island in May,
attended by all staff members as well as the
Scientific Advisory Board, to review research
programs.
• the number of students enrolled in ARMI’s
programs increased significantly. there are
now 11 PhD Students enrolled in the ARMI
Higher Degree by Research (HDR) program,
up from six. In addition, the Institute had six
Honours students and six undergraduate
students through the undergraduate Research
opportunities Program (uRoP).
• two new adjunct professors joined ARMI’s
professorial group: Professor Justin CooperWhite from the university of Queensland’s
• eMBl Australia continued to grow and develop,
launching a student travel grants program,
and establishing the Australian Bioinformatics
network, in partnership with CSIRo and
BioPlatforms Australia. Plans to develop a new
node in South Australia were also announced.
• Plans for the construction of a new aquatics
facility to house axolotls and sharks progressed
well with completion and commissioning of the
new facility expected to be mid-2013.
Dec–08
Dec–09
affiliate
student
technical
academic
admin
Dec–10
Dec–11
Dec–12
admin
academic
technical
student
affiliate
total
armI staff, students and affiliates
Dec-08
4
4
3
0
0
11
Jun-09
6
12
12
6
0
36
Dec-09
8
25
15
7
1
56
Jun-10
8
25
16
13
2
64
Dec-10
10
29
25
13
1
78
Jun-11
8
31
30
18
3
90
Dec-11
7
34
39
15
5
100
Jun-12
7
39
42
25
13
126
Dec-12
8
46
46
32
14
146
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research
grants success rate
2009
2010
2011
funding
source
4.831
4. 090
1. 363
1.192
competitive grant income ($ million)
number of
number
applications successful
success
rate
nHMRC
22
9
41%
ARC
10
3
30%
total
32
12
38%
2012
publications in journals of different
impact factor
publications
2011
2012
journal papers
25
53
book chapters
2
4
books
0
1
total no of publications
27
58
papers in journals
with impact factor > 5
48.0%
45.8%
papers in journals
28.0%
16.7%
papers in journals
4.0%
10.4%
>20
10–20
5–10
<5
academic staff
34
46
journal papers per
academic
0.7
1.0
journal papers with an
impact factor > 10 per
academic
0.4
0.5
2011
2012
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Appointments
promotion
ARMI team leader James Bourne was promoted
to Associate Professor in December 2012. this
promotion arises from James’s steady research
output, student supervision and the development
and coordination of the Institute’s Higher Degree by
Research (HDR) program.
James, who has been at ARMI since 2008, has an
international reputation for his research in the
field of development and regeneration of the visual
system. He is particularly interested in teasing
out the molecular processes of degeneration and
regeneration of the primate neocortex.
His research takes a “cell-to-system” approach,
looking at the pathways, mechanisms and factors
underlying how the human brain processes the
rich visual environment it perceives; at the cellular
level as well as within the system as a whole.
It’s an approach that has granted James and his
team great insights into how the primate visual
cortex has evolved, as well as mechanisms of
neuroplasticity in the developing brain.
ultimately, he hopes to leverage this knowledge into
therapies for injured brains that assist or enable
better repair and greater functional recovery.
study raises hope for stroke treatment
therapy to mend parts of the brain damaged by
strokes has moved a step closer, thanks to
research performed by Associate Professor James
Bourne and his team in collaboration with scientists
from at the Florey Institute of neuroscience and
Mental Health.
James, with ARMI’s Dr Jihane Homman-ludiye and
Dr tobias Merson of the Florey, have discovered
precursor cells, in the visual processing region of
the brains of young marmoset monkeys, that can
form new brain cells in a culture dish.
the work, which was published in April 2012 in
the journal PloS one, raises the possibility of
new therapies for victims of brain injuries such
as stroke.
the team exposed cells obtained from biopsy
samples to various combinations of growth
factors—proteins that promote cell proliferation—
to see if they would multiply and form neurons in
the culture dish.
When treated with two specific growth factors,
some of the cells started to multiply to form
clusters of cells called neurospheres, which are
the forerunners of mature brain cells and thus in a
class of cells called neural progenitors. like stem
cells, these cells can convert into specialist cells to
form various tissues.
the results suggest that precursor cells with the
ability to form new neurons after birth are much
more widespread in the brain than previously
thought. the cells under investigation in this latest
research were isolated from the primary visual
cortex, the brain structure at the back of the head
involved in the processing of stimuli from the eyes.
It’s an area of the brain that is often affected by
brain injury, such as the damage caused by an
ischemic stroke.
Further research is underway to see if the
production of new neurons after birth occurs
naturally in the primary visual cortex, and whether
the mechanism can be activated after injury.
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RESEARCH
Adjunct appointments
In 2012, we continued our program to develop
strong international linkages with leading
researchers. Two new highly ranked international
researchers agreed to adjunct appointments to
the Institute.
Professor Justin Cooper-White
Group Leader, Australian Institute of
Bioengineering and Nanotechnology
Professor Justin Cooper-White is a global
leader in using engineering to solve problems in
biology. He currently holds positions of Associate
Dean (Research) of the Faculty of Engineering,
Architecture and IT; Professor in the School of
Chemical Engineering and Group Leader within
the Australian Institute for Bioengineering
and Nanotechnology—all at the University of
Queensland. He is also Director of the Queensland
Node of the Australian National Fabrication Facility.
Justin’s current research interests include the
development of smart surfaces, scaffolds and
diagnostic microdevices for stem cell expansion,
tissue engineering and early disease detection.
He has published more than 250 research papers,
book chapters and presentations and has seven
international patents in the areas of formulation
design for agriproducts, microbioreactors, particle
synthesis using microfluidic devices and tissue
engineering scaffolds.
Justin is the past President of both The
Australasian Society for Biomaterials and Tissue
Engineering and The Australian Society of
Rheology; a consultant for a number of national
and international companies; associate editor of
the Korean-Australian Rheology Journal; on the
editorial boards of Soft Materials, Biomicrofluidics
and Rheologica Acta; and a reviewer for major
international journals in his fields of expertise.
Justin is developing several collaborative projects
with ARMI Director Nadia Rosenthal.
Professor Francis Stewart
Professor of Genomics, BioInnovationsZentrum,
Technische Universitaet Dresden, Germany
Francis Stewart has held his position as Professor
of Genomics at BIOTEC interdisciplinary research
centre at the Technische Universitaet, Dresden,
since 2001. After completing his undergraduate and
postgraduate studies at the University of New South
Wales, and postdoctoral studies at the German
Cancer Research Centre, he spent nine years as a
Group Leader at EMBL Heidelberg.
Since moving to Dresden he has been highly
influential by developing high-throughput
recombineering in genome-scale applications.
His innovative protein tagging approaches for
systems biology have been the basis of the EU 7th
Framework integrated project SyBoSS (Systems
Biology of Stem Cells and Reprogramming,
www.syboss.eu) which he coordinates. Francis was
made an EMBO Fellow in 2007 and was awarded
the International Society for Transgenic Technology
Prize in 2010. He has also a held a guest Group
Leader position at the Max Planck Institute for Cell
Biology and Genetics in Dresden.
Francis is an internationally recognised scientist
with breakthroughs in the epigenetic mechanisms
in mammalian embryogenesis and in developing
innovative methods to modify gene expression in
mice. He has recently initiated a systems biology
approach to understand the stem cell transitions
focusing on neural stem cells. In future, he will
focus on epigenetic regulators to define the
circuitry of each stem cell state and to infer how
the transitions are accomplished. In particular,
Francis will now focus on the role of epigenetic
mechanisms in the establishment of, and exit from,
naïve pluripotency. After ten productive years in
Dresden, Francis is looking for new challenges
while maintaining continuity and building on his
current activities, and would like to strengthen his
relationship with Australian bioresearch through
this appointment.
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ARMI Scientific Retreat
In late May 2012, students, postdocs, team leaders,
core facility and support staff gathered at the
Silverwater Resort near Philip Island for the threeday retreat. the retreat was also attended by two
members of ARMI’s newly established Scientific
Advisory Board: Professor Peter Rigby (the Institute
of Cancer Research, Royal Cancer Hospital,
london) and Professor Dame Kay Davies (oxford
university). Professors Rigby and Davies provided
valuable feedback to group leaders and researchers
on the direction and progress of their research
programs.
over the three days of the retreat, research
programs were presented, discussed and dissected
in a series of presentations by group leaders and
team members.
In a report to ARMI’s senior management team,
Professor Rigby and Professor Davies commended
the scientists for their novel research programs,
use of the available core facilities and services and
willingness to collaborate. they noted that “overall,
the Institute has made an excellent foundation
on which to build for the future. there are real
opportunities arising from the state-of-the-art
zebrafish facility and the access to marmosets.”
they recommended that future growth at ARMI
proceed in a sustainable fashion, and suggested
that targeted clinical links and recruitment be
considered as the Institute grows.
the next retreat will be held in 2014.
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RESEARCH
EMBL Australia
ARMI is a founding participant and the
headquarters for EMBL Australia, as well as the
host for EMBL Australia’s first research node, the
Victorian node.
EMBL Australia’s key focus to date has been to
develop programs that support Australia’s young
researchers and give them a flying start as they
pursue careers in the life sciences. EMBL Australia
offers talented young scientists up to nine years of
secure funding in state-of-the-art facilities, giving
them the opportunity to take some risks and really
prove themselves. It’s a model that has proven
successful at EMBL in Europe in attracting and
retaining high calibre scientists.
Dr Nicolas Plachta and Dr Edwina McGlinn, the
two ARMI-based group leaders, are now entering
their second and third years, respectively, at EMBL
Australia and their hard work is starting to bear
fruit in the form of publications and additional
research grants. And in partnership with the South
Australian Health and Medical Research Institute
(SAHMRI), EMBL Australia is establishing a new
node in Adelaide, funded by the three main South
Australian universities and the State Government,
to underpin their biomedical informatics
capabilities.
At the other end of the career ladder, EMBL
Australia is providing opportunities for PhD
students to travel overseas to conferences and
training courses at EMBL, exposing them to new
ideas and technologies, and allowing them to begin
building their own network of contacts, a valuable
resource for their future.
EMBL Australia is also focused on building
up Australia’s capabilities, through its unique
collection of resources and alliances, including the
Bioinformatics Resource Australia (BRAEMBL,
formerly known as the EMBL Australia
Bioinformatics Resource), located at the University
of Queensland, and the Australian Bioinformatics
Network, which was formed in partnership with
CSIRO and Bioplatforms Australia. In mid-2012,
Graham Cameron, formerly head of EMBL’s
European Bioinformatics Institute, joined BRAEMBL
as its Director. Through BRAEMBL and the
Australian Bioinformatics Network, we hope that
the local bioinformatics community will flourish.
EMBL Australia’s newest initiative is SBI Australia,
the first international node of Japan’s Systems
Biology Institute. Both EMBL and EMBL Australia
have had a long association with SBI Director,
Professor Hiroaki Kitano, and we are looking
forward to a long and fruitful association. Through
this initiative and others EMBL Australia is
showcasing Australia’s life sciences research
to the world.
About EMBL Australia
EMBL Australia is a joint venture between the
Group of Eight universities and CSIRO, supported by
the Australian Government’s science infrastructure
investments.
EMBL Australia:
• links Australian researchers to international
powerhouses of life science research
• gives early-career researchers secure, longterm research funding which enables them to
take risks and ask big questions
• gives Australia’s best PhD students the chance
to develop international networks and alliances
and “calibrate” their work via EMBL’s European
programs, workshops and conferences
• provides training programs for PhD students
in Australia—giving them a head start in their
science careers
• creates and shares life science resources with
the Australian life science community.
EMBL (the European Molecular Biology
Laboratory)
EMBL is Europe’s flagship for the life sciences. Its
founders had a vision of a supranational research
centre to redress the imbalance caused by US
domination of molecular biology.
EMBL was founded in 1974 and is funded by
contributions from its 20 European member states.
Australia is the first and the only Associate Member.
With nodes in Hinxton (near Cambridge, UK),
Grenoble (France), Heidelberg and Hamburg
(Germany), and Monterotondo (near Rome, Italy),
EMBL comprises about 85 independent research
groups and more than 1,400 people from
60 nations.
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Among its many features are:
• nine years of funding security for research
leaders (subject to performance), after which
they move on
• training for young researchers—over 3,000
per year
• highly sought postdoctoral positions
• internationalising research networks across
europe and around the world
• a culture that focuses on young scientists and
builds strong research alliances.
•
eMBl achieves goals beyond the reach of individual
member states.
•
membership of embL
•
Australia joined eMBl as an Associate Member in
2008. Australia’s Associate Member status runs
until 2014.
Australia’s membership is managed by the
Commonwealth Department of Industry, Innovation,
Climate Change, Science, Research and tertiary
education (now called the Department of Industry).
eMBl Australia maximises the benefits of
Australia’s associate membership of eMBl via
research support, infrastructure development and
training opportunities across Australia.
In 2013, Australia’s status as an Associate
Member of eMBl will be considered for renewal
by both the Australian Government and eMBl’s
executive Council.
embL australia’s core program in 2013
eMBl Australia’s core program consists of the
following research nodes, initiatives and activities:
• Dr edwina McGlinn and her team, at ARMI, are
working to understand skeleton formation—how
do cells in a limb bud know for example whether
to form fingers or an upper arm bone?
• Dr nicolas Plachta and his team, also at ARMI,
can track the movement of proteins as they turn
genes on and off inside living cells—revealing
how individual cells in an embryo change as
they turn into specialised cells such as bone,
nerves or skin.
• the nSW node at the university of Sydney
comprises a single research group, headed by
Dr Marcus Heisler. Marcus is currently based
at eMBl in Heidelberg through the Faculty
•
•
Development Program, supported by the
university of Sydney and the Australia Research
Council, and is due to return to Australia in
2015 or 2016. there are plans for two further
research groups.
the South Australian node comprises three
research groups being created at SAHMRI
(the new South Australian Health and Medical
Research Institute, which is a collaboration
between Flinders university and the universities
of Adelaide and South Australia) focusing on
biomedical informatics. these three groups are
expected to be established in late 2013–2014.
A node will be developed at uWA as funds and
opportunities arise.
the Queensland node hosts the Bioinformatics
Resource Australia (BRAeMBl) at the Institute
of Molecular Biosciences at the university of
Queensland. It provides access to international
and Australian life science data enabling
Australian researchers to access more data
faster. In addition, a research group is likely to
be co-located with the Bioinformatics Resource
at the university of Queensland, subject to
funding arrangements.
the Australian Bioinformatics network is
helping Australian scientists learn how to
work smarter with bioinformatics, and helping
Australian bioinformaticians share information
and ideas. It supports a wide range of activities
across Australia. It is based at CSIRo in
Canberra and funded by eMBl Australia, CSIRo
and Bioplatforms Australia.
SBI Australia, an initiative based at Monash
university, is introducing systems biology to
Australian researchers via direct research,
training and communication. It enables life
scientists to harness computing technology and
engineering methods to simulate complex life
systems—the heart, the immune system, and
whole organisms.
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RESEARCH
2012 Highlights
2013 Outlook
In 2012 EMBL Australia:
• developed and implemented a communications
strategy to spread the word about EMBL
Australia, including monthly newsletters to
interested stakeholders
• launched two student programs to send PhD
students to EMBL for conferences and training
programs
• launched the EMBL Australia alumni group
for former EMBL and EMBL Australia students
and staff
• established the Australian Bioinformatics
Network, as a joint program with CSIRO and
Bioplatforms Australia
• appointed Dr David Lovell as Director of the
Australian Bioinformatics Network
• appointed Mr Graham Cameron as the
Director of Bioinformatics Resource Australia
(BRAEMBL—formerly known as the EMBL
Australia Mirror of the EMBL-EBI)
• appointed Professor Peter Currie as the Head of
EMBL Australia’s Victorian node
• with funding from the University of New
South Wales, sent Simone Li to study at
EMBL’s pre-doctoral program. She is the first
Australian student to study at EMBL through the
International PhD Program
• undertook a Mid-term Review of EMBL
Australia and Australia’s status as an Associate
Member of EMBL
• agreed to host the Australian node of Japan’s
Systems Biology Institute, SBI Australia, at
EMBL Australia’s Victorian node, based at ARMI
• established the South Australian node at
SAHMRI and commenced recruitment for group
leaders
• developed and launched the EMBL Australia
PhD Course, a two-week residential program
for first and second year PhD students.
During 2013 EMBL Australia will:
• recruit up to three new group leaders for the
new node at SAHMRI
• review and develop the EMBL Australia
governance model and develop guidelines for
establishment of new groups and nodes
• establish a senior leadership team to oversee
the further growth of EMBL Australia
• further develop the alumni group and hold
events around Australia
• via the Bioinformatics Resource Australia,
survey bioinformatics users around Australia to
assess scientific needs and concerns
• review services and operations at BRAEMBL,
and develop a clear strategy for the future of
the Resource
• pursue relationships between BRAEMBL and
related Australian projects to mutually enhance
capabilities
• consolidate the role of the Australian
Bioinformatics Network in the Australian
bioinformatics landscape
• increase the number of networking, training
and education events through the Australian
Bioinformatics Network
• continue to progress the student grant
programs to facilitate greater student exchange
• continue to develop and then run the first PhD
Course in July 2013
• examine the viability of an EMBL Australia
PhD program
• build on the current communications strategy
and it expand to encompass all of EMBL
Australia’s nodes and initiatives
• develop SBI Australia as a critical resource for
EMBL Australia
• continue to lead planning and promotion for
the 15th International Conference on Systems
Biology (ICSB 2014), to be held in Melbourne
from 13 to 19 September 2014.
Page
15
SBI Australia
Japan’s renowned Systems Biology Institute (SBI)
has established a node of the Institute in Australia,
allowing it to expand into the Australian scientific
landscape. the headquarters of the new node,
known as SBI Australia, are hosted at ARMI.
SBI Australia is an initiative of eMBl Australia, in
partnership with both ARMI and Monash university.
It will connect Japanese and Australian research
and industry partners, and facilitate the sharing
of scientific technology, resources and expertise,
in order to promote transnational systems biology
research, and deliver tangible benefits to research
and development in both countries.
At the centre of the initiative is the relationship
between ARMI, eMBl Australia and the President
of SBI, Professor Hiroaki Kitano. In March 2012,
eMBl Australia and SBI signed a Memorandum
of understanding to support Australian life
science research through joint activities including
collaboration and sharing of expertise via
workshops, training and other opportunities that
will enhance researchers’ understanding of the
capabilities of genomics and bioinformatics.
the agreement to establish SBI Australia as the
first international node of the Systems Biology
Institute was signed by Monash university Provost
and Senior Vice-President, Professor edwina
Cornish, in tokyo in october.
SBI Australia will develop and support Australian
systems biology capacity through research, training
and outreach, and will provide the platform to
connect and promote Australian research to the
international systems biology community.
the current direction of the SBI Australia research
program includes:
• characterising the systems that control the
development of the first few cells in an embryo,
with applications to improved IVF technologies
• understanding the different heart cell
populations, especially non-myocyte cells
(that is, cells other than muscle cells), to
improve understanding of the normal and
ageing adult heart
• investigating the robustness and fragility of
coral reefs, which are affected by environmental
perturbations, to develop countermeasures for
coral bleaching that is a threat to the survival of
coral reefs globally.
• facilitating access to Australia’s highperformance computing capacity, to support
systems biology research through the provision
of computing power
• facilitating access to software platforms and
resources such as the Garuda Alliance, which
is developing an open standard for sharing
systems biology data and information, and
Flint, which provides the interface to highperformance computing resources.
SBI Australia also offers training to undergraduate
and postgraduate students, and to postdoctoral
researchers, in all relevant disciplines including
biology, mathematics, computer science, physics,
engineering, and chemistry.
2012 highlights
• Dr Sarah Boyd was appointed Developer,
Systems Biology Research Platform, to lead the
development of SBI Australia.
• SBI Australia was established at a signing
ceremony on 17 october 2012 at the
Ambassador’s Residence, Australian embassy,
tokyo.
• the Australia-Japan Workshop on Biomedical
Breakthroughs and Systems Biology was held
on 16 october 2012 at the Japan Science and
technology Agency tokyo Headquarters 2.
• An ARC Discovery Project Grant “Systems
modelling of the cardiac fibroblast” was
awarded ($270,000 over three years).
• the SBI Australia Steering Committee was
established.
• Professor Hiroaki Kitano was appointed
Sir louis Matheson Distinguished Visiting
Professor.
• Dr Samik Ghosh was appointed an Adjunct
Research Fellow.
• Dr Yukiko Matsuoka was appointed an Adjunct
Research Associate.
systems biology conference
In late 2011, a consortium led by eMBl Australia
successfully bid to host the 15th International
Conference on Systems Biology (ICSB) in
Melbourne from 13 to 19 September, 2014, at the
Melbourne Convention and exhibition Centre.
eMBl Australia and SBI Australia will use the
opportunity of hosting the conference to boost the
profile of systems biology in Australia.
Preparations for the conference got underway
during 2012, with confirmation of the dates
and location as well as convening of the event
management team to start developing the program.
the activities associated with eMBl Australia and
SBI Australia place ARMI on a firm national and
international footing, and support the thematic
approach of the Institute to progress outstanding
science and pursue national and international
collaborations.
Page
16
research
Rosenthal Group
the rosenthaL group’s research
concentrates on heart deveLopment,
Immune and stem ceLL-drIven repaIr
of neuromuscuLar and cardIac
tIssue, and LImb regeneratIon,
usIng the mouse and saLamander
as modeLs for human response to
damage and dIsease.
Page
17
the Group is defining the factors that lead to a
regenerative response and how these factors differ
in a fibrotic response to injury, comparing the
roles played by blood cell lineages in controlling
inflammation and promoting tissue repair in
mammals and urodele amphibians. their research
is exploring the exciting possibility of replacing
damaged body parts through the new field of
regenerative medicine using gene therapy, cell
transplantation and the induction of regeneration
from the body’s own cells by altering the injury
environment.
2012 highlights
• Dr ekaterina Salimova joined the laboratory
as a Research Fellow.
• Dr Alex Pinto published “An abundant tissue
macrophage population in the adult murine
heart with a distinct alternatively-activated
macrophage profile” in PloS one.
• nicholas lam published “nerve growth
factor stimulates cardiac regeneration via
cardiomyocyte proliferation in experimental
heart failure” in PloS one.
group members
group Leader
Professor nadia Rosenthal
research fellows
Dr Minna-liisa Anko (until May)
Dr Mauro Costa
Dr Milena Furtado
Dr James Godwin
Dr Alex Pinto
Dr lina Wang
Dr ekaterina Salimova
research assistant
Anjana Chandran
Mr Drew Kuraitis (visiting from September)
phd student
nicholas lam
honours student
Ryan Debuque
adjunct
Dr Minna-liisa Anko (from May)
collaborations
Growth factors and cardiac stem cells
Professor Richard Harvey, Victor Chang Cardiac
Research Institute, Sydney, Australia
Stem cell delivery in cardiovascular disease
Dr Keith Mclean, CSIRo, Australia
Heart regeneration in zebrafish
Professor David Kaye, Baker Heart Institute,
Melbourne, Australia
Macrophages in lung disease
Professor Gary Anderson, university of Melbourne,
Australia
IGF-1 in muscle regeneration
Professor Miranda Grounds, university of Western
Australia, Perth, Australia
Molecular mechanisms of cardiac recovery
Professor Michael Schneider, Imperial College
london, uK
Tissue factor and heart repair
Professor Dorian Haskard, Imperial College
london, uK
Role of IGF- l in countering muscle disease
Associate Professor Antonio Musaro, university of
Rome la Sapienza, Italy
Role of PWI in cardiac development and stem cell
function
Dr David Sassoon, université Paris VI/Pierre et
Marie Curie, France
Page
18
research
Currie Group
research In the currIe Laboratory
focuses on attempts to understand
how the ceLLs of the vertebrate
myotome are specIfIed to become
IndIvIduaL muscLe ceLLs Later In
deveLopment. we concentrate
on two dIfferent popuLatIons of
dIfferentIatIng muscLes, those that
form the muscLes of the axIs and
those that generate the muscLes
of the fIns. we are Interested In
the moLecuLar mechanIsms that
make muscLes grow and the stem
ceLL popuLatIons that are used to
coordInate thIs process In normaL
growth and regeneratIon. we are
aLso Interested In how thIs process
has evoLved throughout vertebrate
specIes, and examIne the embryos of
numerous LIvIng fIshes In an attempt
to answer thIs questIon.
We are also are intrigued by zebrafish mutations
that fail to undergo or retain the normal pattern
of muscle differentiation within the embryo. We
are particularly intrigued by mutations that mirror
the onset of human muscular dystrophy and have
developed zebrafish models of common muscular
dystrophies. Muscular dystrophies are musclewasting diseases and among the most common
genetic diseases of the newborn. they inflict
debilitating symptoms, are often fatal, and there
are no effective cures.
the Currie Group has developed models of
dystrophies in zebrafish and discovered that muscle
cells detach during contraction. using the visually
transparent nature of zebrafish in combination with
nanofabrication, the Group is testing a new method
to re-build damaged muscle attachment sites to
allow muscles to survive. the Group was the first
to investigate zebrafish as a model for muscular
dystrophy, a critical discovery for modelling human
muscle pathology and among the first reports of a
zebrafish model of a human disease.
the Group provides resources and tools for the
international zebrafish community and have
developed novel imaging techniques, including
optical projection tomography and X-ray
tomography, to generate detailed 3D anatomical
maps of zebrafish. the group has also developed an
online anatomical resource for zebrafish—the first
embryo-to-adult atlas of any species in 3D.
www.fishnet.org.au
2012 highlights
• Group members published 14 peer-reviewed
papers.
• Group members were awarded two nHMRC
grants, “Modelling laminin mediated adhesion
and congenital muscular dystrophy in zebrafish”
and “Molecular mechanisms that generate and
activate muscle stem cells during growth and
disease”.
• Group members were awarded an ARC grant.
• Group members received an ARC linkage
Grant “Generation of a mutational resource in
Zebrafish”.
• Dr Patricia Jusuf was awarded a prestigious
ARC DeCRA Fellowship “Role of intrinsic versus
extrinsic cues in cell type determination during
development and regeneration”.
Page
19
research publication
highlights 2012
group members
Goldshmit Y, Sztal TE, Jusuf PR, Hall TE, NguyenChi M, Currie PD. Fgf-dependent glial cell bridges
facilitate spinal cord regeneration in zebrafish. J
neurosci. 2012 May 30;32(22):7477-92.
Professor Peter Currie, Deputy Director, ARMI
understanding how the spinal cord of zebrafish
can regenerate so effectively was a new research
direction for the Group in 2012. A major goal of
this research direction is to understand the signals
and processes that zebrafish use to undergo
regeneration and why they differ to the nonregenerative context of mammalian spinal cord
injury. Amazingly, after a full spinal cord resection
zebrafish can fully regenerate nerves and their
connections in the spinal cord to generate full
locomotor recovery. this exciting paper describes
the molecular signal and cellular behaviours that
zebrafish use to regenerate their spinal cord.
Nguyen-Chi ME, Bryson-Richardson R, Sonntag
C, Hall TE, Gibson A, Sztal T, Chua W, Schilling
tF, Currie PD. Morphogenesis and cell fate
determination within the adaxial cell equivalence
group of the zebrafish myotome. PloS Genet.
2012;8(10):e1003014.
one of the core interests of the Currie Group is to
understand how muscle cells arise in the early
embryo. this paper reveals that an intruiging
interplay of signals and cell movements generate
the early muscle of the zebrafish embryo that gives
a window on how different cells are programmed to
make different muscle types.
Sztal TE, Sonntag C, Hall TE, Currie PD. epistatic
dissection of laminin-receptor interactions in
dystrophic zebrafish muscle. Hum Mol Genet. 2012
nov 1;21(21):4718-31.
one of the focuses of the Currie Group is to use
the zebrafish model to understand how the loss
of certain genes leads to the onset of muscular
dystrophy. this paper examines zebrafish models of
two of the most common forms of human muscular
dystrophy, Duchenne muscular dystrophy and
congenital muscular dystrophy, and examine how
the genes mutated in these disorders coordinate
muscle cell integrity in living muscle tissue.
group Leader
research fellows
Dr Joachim Berger
Dr Catherine Boisvert
Dr thomas Hall (until January)
Dr Patricia Jusuf
Dr Yona Goldshmit
Dr Ivana Mirkovic (from September)
Dr Ashley Siegel
research assistants
Ms Carmen Sontag
Ms Silke Berger
Ms Fruszina Fenyes (from August)
Ms lei Mei
phd students
Ms ophelia erhlich
Mr David Gurevich
Mr Wouter Masselink
Mr Phong nguyen
Mr Zhenhua li
collaborations
Nano particle and tube for in vivo ECM assembly in
zebrafish
Dr Patrick Hartley, Dr Richard Williams, Dr Keith
Mclean, CSIRo, Australia
Muscle attachment in the zebrafish embryo
Professor tom Schilling, university of California,
Irvine, uSA
Testing muscle disease models in zebrafish
Professor Christina Mitchell, Monash university,
Mutants affecting muscle formation in zebrafish
Professor Didier Stainier, university of California,
San Francisco, uSA
The role of Lbxl in development
Dr Christine thisse, Institute de Génétique et de
Biologie Moléculaire, Strasbourg, France
Generating a mutation resource in zebrafish
Professor Graham lieschke, ARMI
Heart regeneration in zebrafish
Professor nadia Rosenthal, ARMI
Page
20
research
Barberi Group
stem ceLL bIoLogy offers great
promIse for fIndIng new treatments
for degeneratIve dIseases and
cancer. stem ceLL dIfferentIatIon
studIes are aLso heLpIng to reveaL
ceLLuLar and moLecuLar mechanIsms
governIng ceLL fate and tIssue
specIfIcatIon.
Page
21
the Barberi Group is researching methods to
isolate specific stem/precursor cells originating
from human embryonic stem cells (heSC) that
may have therapeutic applications. using heSC
as a research tool, the Group also aims to address
fundamental questions in development, such as
how pluripotent cells undergo lineage restriction
and fate specification. In particular, the Group is
interested in the development and differentiation
of striated skeletal muscle cells, the development
and differentiation of the retina, and neural crest
and cranial placode specification during early
neurulation.
group members
the Group is also studying neural development
using mutant mouse eSC lines. they are examining
how misexpression of Wnt-l could affect the neural
differentiation potential of eSCs, and analysing
the role of the transcription factor SCl/tall during
neural development using specific gain of-function
and lack-of-function SCl/tall mutant eSC lines.
Ms Bianca Borchin
group Leader
Associate Professor tiziano Barberi
research fellows
Dr Isabella Mengarelli (until September)
Dr Joly Kwek
research assistant
Mr Joseph Chen (from March)
phd student
collaborations
Dr Jose Polo, Monash Immunology and Stem
Cell laboratories, Monash university, Melbourne,
Australia
Professor Giovanni Morrone, university of
Catanzaro, Italy
Professor Jonathon Crowston, Centre for eye
Research Australia (CeRA), Melbourne, Australia
Page
22
research
Bourne Group
damage or trauma to the braIn has
profound Impact on IndIvIduaLs,
theIr famILIes and the heaLth care
system. these types of InjurIes
occur as a resuLt of, for exampLe,
a car accIdent or stroke. no current
treatments wILL effectIveLy repaIr
or promote the regrowth of
damaged braIn tIssue.
Page
23
the Bourne Group is addressing the molecular
processes of degeneration and regeneration of cells
in a region of the brain known as the neocortex of
the primate. examining how this region responds
at different ages is a key step to understanding why
the young brain has a remarkable capacity to repair
itself following an injury, while the adult brain does
not. the Bourne Group is trying to elucidate the key
mechanisms of repair in the infant brain in order
to attempt to recapitulate the process in the adult
following an injury.
the Group is tackling these questions from a
cell-to-system approach, looking at how cells in
culture respond to certain molecules through to
observing physiological and anatomical changes
in the animal model.
2012 highlights
• Group leader James Bourne was promoted to
Associate Professor.
• Associate Professor James Bourne was
awarded an nHMRC Project Grant for
“A role for the pulvinar nucleus in visual cortical
development and plasticity”.
• Group members published six papers in
internationally renowned journals.
• Group members gave presentations at leading
overseas meetings.
• the first demonstration of the existence of
neural precursor cells in the visual cortex of the
non-human primate.
• Faculty of 1000 recommended the journal
article: Warner, C.E., W.C. Kwan, and J.A.
Bourne, the early Maturation of Visual Cortical
Area Mt is Dependent on Input from the
Retinorecipient Medial Portion of the Inferior
Pulvinar. J neurosci, 2012. 32(48)17073-17085.
this work demonstrated the importance of
the pulvinar nucleus in the development of the
visual cortex.
• Associate Professor James Bourne participated
on the nHMRC Project Grant Review Panel.
group members
group Leader
Associate Professor James Bourne
research fellow
Dr Jihane Homman-ludiye
research assistant
Mr William Kwan
phd students
Mr leon teo
Ms Claire Warner
affiliates
Dr tobias Merson
Dr Julie thacker (from June)
Professor Anita Hendrickson
honours/urop students
Ms Skye Kinder
Mr Anthony Boghdadi
collaborations
Stem cells and repair in the injured nonhuman
primate visual cortex
Dr toby Merson, Professor trevor Kilpatrick, Florey
neurosciences Institute, Melbourne, Australia
The role of Eph/ephrins in brain development
and repair
Dr Jennifer Rodger, School of Zoology, university of
Western Australia, Perth, Australia
Developmental plasticity in the nonhuman primate
visual cortex
Dr Samuel Solomon, Department of Physiology,
university of Sydney, Australia
Novel conjugated biomaterials in the treatment of
neurotrauma and neurodegeneration
Professor Jeffrey Rosenfeld, Alfred Hospital,
Melbourne; Dr Pat Hartley, Dr Keith Mclean,
Biomedical Materials, CSIRo, Australia
Hydrogels for the treatment of brain injury
Dr John Forsythe, Dr David nisbet, Department
of Materials engineering, Monash university,
Distribution of molecular guidance molecules
in the primary sensory fields of the developing
marmoset monkey
Dr Zoltan Molnar, Department of Physiology,
Anatomy and Genetics, university of oxford, uK
Diffusion imaging of the nonhuman primate visual
system following lesions of the neocortex
Professor Gary egan, Dr leigh Johnston,
Dr Scott Kolbe, Florey neuroscience Institute,
Page
24
research
Heng Group
the heng group joIned armI In june
2010 wIth the appoIntment of dr
juLIan heng foLLowed by members of
hIs team. the heng group InvestIgates
the moLecuLar and ceLLuLar
mechanIsms that controL nerve ceLL
productIon and maturatIon wIthIn
the mammaLIan braIn. the group uses
moLecuLar technIques to study the
bIrth and deveLopment of cerebraL
cortIcaL neurons wIthIn the foetaL
mouse braIn In vIvo as weLL as In
vItro. these studIes are combIned
wIth bIoInformatIcs approaches
to IdentIfy, then characterIse,
genes responsIbLe for aspects of
the maturatIon of newborn nerve
ceLLs. uLtImateLy, the goaL of our
research Is to use our fIndIngs to
dIrect the productIon of specIfIc
neuraL ceLL types from donor stem/
progenItor ceLLs, and to deveLop
these as noveL substrates for braIn
transpLantatIon and repaIr In braIn
Injury or dIsease.
Page
25
In a parallel approach, the Heng Group investigates
the genetic basis for structural brain disorders
(such as microcephaly) in humans. these studies
have led to the identification of novel genes which,
when mutated, cause brain developmental defects.
one important goal from this work is to identify
novel genetic markers for diagnostic testing of
patients with brain developmental disorder. In the
future, these studies could eventually lead to the
development of new treatments, gene therapies
or patient-specific clinical interventions for the
treatment of their neurodevelopmental disorders.
2012 highlights
• Group members were awarded an ARC
Discovery Project Grant “Subcellular
recruitment of a RhoA ubiquitination complex
by Rnd proteins”.
group members
group Leader
Dr Julian Heng
research fellows
Dr Matilda Haas
Dr lieven Huang
research assistants
Mr Zhengdong Qu
Ms Shanshan li
Ms linh ngo
phd student
Mr Ivan ng
honours student
Ms Stephanie Houston
collaborations
Transcriptional control of neural development
Dr Haruo okado, Dr Chiaki ohtaka-Maruyama,
tokyo Metropolitan Institute for neuroscience,
Japan; Professor Masataka Kasai, national
Institute of Infectious Diseases, Japan; Dr Francois
Guillemot, the national Institute for Medical
Research, uK
The genetics of mammalian brain development
Professor Seong-Seng tan, the Florey Institute of
neuroscience and Mental Health, Australia
The effects of prenatal drug exposure in brain
patterning and function
Dr Christopher Reid, the Florey Institute of
neuroscience and Mental Health, Australia
The genetics of brain developmental disorders
in humans
Dr David Keays, Institute of Molecular Pathology,
Austria
Page
26
research
Hobbs Group
dr robIn hobbs reLocated from
beth IsraeL deaconess medIcaL
center assocIated wIth harvard
medIcaL schooL In boston In earLy
2012 and has a joInt appoIntment
wIth the department of anatomy and
deveLopmentaL bIoLogy at monash
unIversIty.
Page
27
the main focus of the Hobbs Group is to define
critical mechanisms underlying adult stem cell
function through use of germline stem cells from
the mouse testis as a model. Maintenance of a wide
array of adult tissues is dependent on a resident
population of stem cells that must self-renew
and generate differentiating daughter cells. the
appropriate control of stem cell self-renewal and
differentiation is critical for tissue homeostasis
while disruption of the balance between these
processes can contribute to tissue degeneration
or cancer.
the adult testis contains a population of germline
stem/progenitor cells (known as spermatogonial
progenitor cells or SPCs) that are required for
life-long production of differentiating germ cells
and spermatozoa. A handful of cell intrinsic factors
are known to be involved in SPC maintenance,
foremost among which is the transcription factor
Promyelocytic leukaemia Zinc Finger (PlZF).
A major focus of the Hobbs Group is to define
downstream targets of PlZF in SPCs and their
role in SPC function. this is achieved by using a
combination of mouse genetics, flow cytometry
analysis and in vitro culture techniques. the
principal aim of this research is to identify and
characterise molecular mechanisms underlying
adult stem cell function. this work has particular
relevance for our understanding of male infertility
and can suggest novel therapeutic approaches
aimed at improving adult stem cell function and
tissue repair following injury.
2012 highlights
• Dr Robin Hobbs was awarded a Monash
university larkins Fellowship to establish his
laboratory at ARMI.
• Dr Hobbs started as a group leader at ARMI in
February, having relocated from the Beth Israel
Deaconess Medical Center, associated with
Harvard Medical School, uSA.
• Dr Hobbs published a high-profile first author
paper in the Cell Stem Cell journal and a cosecond author paper in Cell.
• Dr Hobbs was invited to present his work
at the annual conference of the Society for
Reproductive Biology and endocrine Society
of Australia.
• Dr Hobbs was awarded an nHMRC Project
grant “Role of PlZF – SAll4 interactions in
germline progenitor function and development”.
group members
group Leader
Dr Robin Hobbs
research assistant
Ms Mia de Seram (from June)
collaborations
Role of the GILZ gene in male germline stem cell
maintenance and fertility
Professor eric Morand, Department of Medicine,
Centre for Inflammatory Diseases, Monash Medical
Centre, Monash university, Melbourne, Australia
Characterising the role of Activin signalling in
postnatal testis development
Professor Kate loveland, Department of
Biochemistry & Molecular Biology, Monash
university, Melbourne, Australia
Generation and characterisation of germline stem
cell-derived pluripotent stem cells
Professor Fiorella Altruda, Molecular Biotechnology
Center, university of turin, Italy
Page
28
research
Kaslin Group
the kasLIn group focuses on
understandIng the moLecuLar and
ceLLuLar mechanIsms that controL
ceLLuLar pLastIcIty In the Intact and
Injured vertebrate braIn.
Page
29
neural stem cells and brain regeneration have been
mostly studied in vertebrates (rodents) that have
very limited neurogenic potential. In contrast, we
have found that zebrafish exhibit widespread adult
neurogenesis and are able to regenerate parts of
their central nervous system. these features make
it possible to tackle questions in the zebrafish that
are not possible in mammalian models. our overall
aim is to understand the underlying molecular
and cellular mechanisms that allow/limit cellular
plasticity in the vertebrate brain.
the group uses high-resolution in vivo imaging,
novel genetic tools and cellular reprogramming
to study how neuronal stem cell niches and tissue
permissiveness arise and are being maintained.
using high-throughput sequencing we want to get
a comprehensive understanding of the genetic
networks that regulate cellular plasticity during
homeostasis and regeneration. the elucidation
of the mechanisms that govern cellular plasticity
in vivo is essential for successful central nervous
system therapies in the future.
group members
group Leader
Dr Jan Kaslin
research assistants
Ms Krutika Wikhe (until June)
Ms Jean tang
Mr Raphael Park Chae
Mr Sunil Kumar (from August)
phd student
Ms Frisca Frisca
urop students
Mr Daniel Colquhoun
Ms Celia Vandestadt
collaborations
Development & regeneration of hypothalamic
circuits
Dr Gil lewkowitz, Weizmann Institute, Israel
Wnt signalling & regeneration
Dr Gilbert Weidinger, university of ulm, Germany
Genome-wide analysis of brain regeneration in
zebrafish
Dr Michael Brand, Center of Regenerative
therapies Dresden, Germany
Tools for studying signalling pathway activity in
zebrafish
Dr Francesco Argenton, university of Padua, Italy
Page
30
research
lieschke Group
the LIeschke group joIned armI
In november 2010, transferrIng
from the cancer and haematoLogy
dIvIsIon of the waLter and eLIZa
haLL InstItute of medIcaL research,
meLbourne. the group studIes bLood
deveLopment and functIon usIng
ZebrafIsh and was one of the fIrst
groups In the worLd to use the
genetIc fLexIbILIty and LIve ImagIng
capacIty of ZebrafIsh for whIte
bLood ceLL research. the group has
aLso deveLoped an InfectIon modeL
to InvestIgate the roLe of whIte
bLood ceLLs (Leukocytes) In the hostpathogen response.
Page
31
the haemopoietic system makes blood cells and
is a prolifically regenerative tissue, constantly
supplying blood cells throughout life. It is capable of
large bursts of replenishment following injuries and
interventions such as chemotherapy. leukocytes
are key cellular players in host defence and as
effectors of inflammation. their function plays a
major role in determining the balance between
ongoing tissue injury, scarring, healing and
regeneration.
Professor lieschke is internationally recognised
for his research into blood disorders and cancer
using zebrafish and mice. He is also a clinical
haematologist at the Royal Melbourne Hospital,
where he treats patients with leukaemia and
lymphoma.
2012 highlights
• Group members identified a way that white
blood cells turn off the signal that first attracts
them to a site of inflammation, published in
Current Biology.
• Many researchers around the world are using
transgenic macrophage reporter zebrafish lines
recently developed in the lab.
group members
group Leader
Professor Graham lieschke
research fellows
Dr Cristina Keightley
Dr Felix ellett
Dr Chieh-Huei Wang (from october)
senior research assistant
Ms Sony Varma
phd students
Mr Sultan Alasmari
Mr Vahid Pazhakh
urop student
Ms emily Scott
visiting student
Mr Johannes Wittig
collaborations
An in vivo model of infection with the opportunistic
human pathogen Penicillium marneffei
Associate Professor Alex Andrianopoulos,
Department of Genetics, university of Melbourne,
Australia
Characterisation of a novel BTB-ZF transcription
factor
Professor Stephen Jane, Bone Marrow Research
laboratories, Royal Melbourne Hospital,
Live imaging and quantification of leukocyte
migration in vivo
Dr Stephen Renshaw, university of Sheffield, uK
Cloning and characterisation of zebrafish mutants
with defects of intestinal development
Associate Professor Joan Heath, ludwig Institute
for Cancer Research, Melbourne, Australia
Tools for studying leukocyte behaviours in
zebrafish
Professor Phil Crosier, university of Auckland,
new Zealand
Building an Australian zebrafish TILLING library
Associate Professor Joan Heath, ludwig Institute
for Cancer Research, Melbourne, Australia;
Professor Peter Currie, ARMI
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32
research
Marcelle Group
the marceLLe group Is Interested
In understandIng how functIonaL
skeLetaL muscLe arIses from a
group of unspecIaLIsed mesodermaL
ceLLs. to achIeve thIs, crucIaL ceLL
fate decIsIons, extensIve mIgratIon,
tIghtLy reguLated ceLL dIvIsIons
take pLace In just a few days of
embryonIc deveLopment. we want
to understand the ceLLuLar and
moLecuLar processes that underLIe
thIs compLex process.
Page
33
the animal models on which we perform our
experiments are the mouse and chick embryos.
the first aim of our research is to observe the
complex cellular events that take place during
muscle formation, using cutting-edge in vivo
imaging technologies. the second aim is to
understand the molecular mechanisms underlying
muscle fusion. Finally, we want to identify gene
networks implicated in the maintenance and
differentiation of muscle stem cells.
Professor Christophe Marcelle is a world leader
in the application of developmental biology to the
study of muscle growth and regeneration. His
work has illuminated key aspects of how muscle
precursor cells form in the early embryo and how
they contribute to muscle growth throughout life.
Christophe’s work at ARMI continues his focus
on muscle development and stem cell biology,
with the ultimate aim being to understand how
the muscle organ system forms. Before joining
ARMI, Christophe led a research group at the
Developmental Biology Institute of Marseilleluminy (IBDMl) at the university of Marseille
in France.
research themes
muscle stem cells
We utilise an integrated systemic approach to
define a core gene network governing “stemcellness” in muscle. A first part of the project
involves the generation of new mouse lines.
Isolated stem cells from these lines are then
used to perform microarray, and ChIP-seq
analyses. Functional analyses are performed
in the chick embryo.
myoblast fusion
Skeletal muscle-fibres are plurinucleated.
this occurs through multiple rounds of myoblast
fusion, taking place during development and during
muscle regeneration and repair in the adult.
A whole genome screen has been made to identify
putative candidate genes important in fusion.
We are now performing functional analyses in the
chick and mouse embryos.
morphogenesis of skeletal muscles
Muscle tissue is extremely well organised, fibres
are aligned in a precise direction, and their
attachment points are well defined. How this
process is regulated at a cellular and molecular
level is unknown. High-end imaging technologies
are used to address this question in live chick
embryos.
2012 highlights
• Cyril Picard published his PhD thesis.
• Group members published six papers.
• Group members were awarded two nHMRC
grants.
• Professor Christophe Marcelle attended four
international conferences and was keynote
speaker at the Israel Society for Development
Biology Conference.
group members
group Leader
Professor Christophe Marcelle
research fellows
Dr olivier Serralbo
Dr Claire Hirst (from September)
Dr Frederico Calhabeu (from May)
Dr Ashvind Prahahran (until September)
research assistants
Mr Cyril Picard (until December)
Ms nadege Veron
phd student
Mr Daniel Sieiro Mosti
honours student
Jeremy ng Chi Kei
urop student
Mr Mark Sedrak
adjunct/affiliates
Dr David Salgado
Dr Manuel Pele
Page
34
research
McGlinn Group
the mcgLInn group uses the
deveLopIng LImb bud and axIaL
skeLeton to understand genetIc
hIerarchIes governIng patternIng
mechanIsms.
Page
35
the reiterative use of key signalling pathways
across multiple organs has meant that the limb,
with its advantages of ease of manipulation and lack
of requirement for embryonic survival, has provided
fundamental contributions to our understanding of
broader developmental processes.
More recently, it has become clear that a
comprehensive understanding of these processes
requires integration of all levels of gene regulation,
including both protein-coding and non-proteincoding mechanisms.
For this reason, we have pioneered a novel
approach to investigate the role of microRnAs
in development.
We aim to build a more complete molecular
roadmap of how the size, shape and number of
bones form within the early vertebrate embryo.
group members
group Leader
Dr edwina McGlinn
research fellow
Dr Alysha Heimberg
Dr Jesus Casanova (from July)
research assistant
Ms lisa Wong
phd student
Mr eamon Coughlin
affiliate
Mr Janus Jacobsen (from January to July)
collaborations
2012 highlights
• Dr Jesus Casanova joined the McGlinn Group in
July 2012. Jesus received his PhD at the CnIC,
Madrid, Spain, and is interested in the regulation
of vertebral number by microRnAs.
• Dr edwina McGlinn was awarded a nHMRC
project grant “elucidating the role of miR-196 in
formation of the axial skeleton”.
• Group members published one research
article in the high impact journal Genes and
Development and two review articles.
A role for miR-196 in patterning the vertebrate
embryo
Professor Clifford tabin, Harvard Medical School,
uSA; Professor David Bartel, Whitehead Institute,
MIt, uSA
The microRNA repertoire of the King Cobra,
Ophiophagus hannah
Professor Michael Richardson, leiden university,
the netherlands
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36
research
Plachta Group
reveaLIng the dynamIc mechanIsms
that pattern a mammaLIan embryo Is
key to understandIng human bIoLogy
and dIsease, yet few experImentaL
systems permIt the study of dynamIc
physIcaL aspects of ceLLs and
moLecuLes In LIvIng mammaLIan
embryos.
Page
37
the Plachta Group combines single-cell imaging
and quantitative methods to discover how the
dynamic behaviour of DnA-binding molecules
controls the development of the first specialised
cells in living mouse embryos. the Group recently
established new experimental assays to visualise
the movement of transcription factors, which
are key regulatory molecules controlling gene
expression, in four dimensions (x, y, z and time).
2012 highlights
the Group undertakes in imaging in real time at
the single-cell level in intact embryos. this
approach allows them to probe biochemical events
typically studied in fixed specimens or in cell
homogenates often lacking the spatiotemporal
dynamics of in vivo systems.
Dr nicolas Plachta
Group members extend these studies by comparing
pluripotent cells in the embryo to several stem cell
lines cultured in vitro, which are derived from the
actual embryo (such as embryonic stem cells) or
that are reprogrammed from somatic cell lineages
(induced pluripotent stem cells). In addition, the
Group has developed live imaging tools to study the
cellular mechanisms governing the formation of
the first tissue-like structures in the embryo, with a
particular focus on cell movements and formation
of the central nervous system.
• Dr nicolas Plachta was awarded an nHMRC
grant “Revealing how transcription factors
search the DnA to control preimplantation
development in mammals”.
group members
group Leader
research fellows
Dr Gurpreet Kaur
Dr Juan Carlos Fierro-Gonzalez (from March)
Dr Melanie White (from May)
Dr Jennifer Zenker (from December)
research assistant
Mr Juan Silva
affiliate
Mr tim Hast (from September)
collaborations
Imaging the dynamics of cell reprogramming
Dr Jose Polo, MISCl, Monash university,
Analysing gastrulation in mammals
Dr Samuel ojosnegros, California Institute of
technology, uSA
Designing new tools for single-cell imaging
Dr Sarah Boyd, School of Mathematics, Monash
university, Australia
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38
research
Polo Group
the group Is Interested In the
transcrIptIonaL and epIgenetIc
mechanIsms that govern ceLL
IdentIty, In partIcuLar pLurIpotency
and the reprogrammIng of somatIc
ceLLs Into Induced pLurIpotent stem
(Ips) ceLLs.
Page
39
Being able to reprogram any specific mature
cellular program into a pluripotent state, and
from there back into any other particular cellular
program, provides a unique tool to dissect the
molecular and cellular events that permit the
conversion of one cell type to another. Moreover,
iPS cells and the reprogramming technology are
of great interest in pharmaceutical and clinical
settings. the technology can be used to generate
animal and cellular models for the study of various
diseases and may in the future provide cells tailormade for a specific patient to be used in cellular
replacement therapies. However, despite being
one of the major growing research fields, very little
is known about the epigenetic and transcriptional
changes occurring during this process.
understanding the events leading to the generation
of iPS cells is a necessary step to ultimately using
iPS cell technology for therapeutic purposes. By
using a broad array of approaches through the use
of mouse models and a combination of different
molecular, biochemical, cellular techniques and
genome wide approaches, our lab aims to dissect
the nature and dynamics of such events.
We are particularly interested in the following
aspects:
• the kinetics and universality of the epigenetic
and genomic changes occurring during
reprogramming
• the composition and assembly kinetics of
transcriptional regulation complexes at
pluripotency genes
• how the cell of origin influences the in vitro and
in vivo plasticity potential of cells generated
during the reprogramming process
• the epigenetic changes occurring in adult stem
cells as a consequence of changes in their
environment.
2012 highlights
• Dr Jose Polo became a nHMRC Career
Development Fellow in January 2012.
• Dr Polo was awarded two nHMRC project
grants to start in 2013.
• the Group published a paper in the journal
Cell: Polo, J.M., e. Anderssen, R.M. Walsh,
B.A. Schwarz, C.M. Nefzger, S.M. Lim, M.
Borkent, e. Apostolou, S. Alaei, J. Cloutier,
o. Bar-nur, S. Cheloufi, M. Stadtfeld, M.e.
Figueroa, D. Robinton, S. natesan, A. Melnick,
J. Zhu, S. Ramaswamy, and K. Hochedlinger,
“A Molecular Roadmap of Reprogramming
Somatic Cells into iPS Cells”.
• Dr Polo published a paper in Cell Reports.
group members
Dr Susie nilsson, CSIRo
Dr Stefan White, Monash Institute of Medical
Research
Professor ed Stanley, Monash university
Professor Andrew elefanty, Monash university
Dr Helen Abud, Monash university
Dr nicolas Plachta, ARMI
Associate Professor tiziano Barberi, ARMI
collaborations
group Leader
Dr Jose Polo
research fellows
Dr Sue Mei lim
Dr Christian nefzger
phd student
Sara Alaei
undergraduate student
Jaber Firas
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40
“
High-end core research
facilities are integral
to the ARMI research
program and to enabling
our researchers to
maximise their research
output and quality. Along
with Monash University
and with the support
from the Victorian and
Australian governments,
the Institute has invested
significantly in these very
important assets.
Page
41
FishCore
FishCore is the largest zebrafish facility of its kind
in the southern hemisphere. It includes 1,000
quarantine and 5,200 non-quarantine tanks.
In 2010, the FishCore team grew the number of
zebrafish strains to 29. the facility is now operating
at 85% capacity, servicing ARMI research groups
and an external research team. through an
alliance with Box Hill tAFe, animal husbandry
students have gained work experience at FishCore.
two students from this program have gone on
to be engaged as casual employees. FishCore is
undergoing an expansion to also house axolotls
and sharks. Design of the facility is underway, with
construction expected to commence in 2013.
As part of this expansion, the team, in collaboration
with ARMI researchers, has established pilot
axolotl and shark facilities. using these facilities,
research programs using these models have been
established in the lead-up to the construction of the
AquaCore facility.
facilities
•
•
•
•
PC2 zebrafish housing facilities
PC2 research microinjection facilities
AQIS-approved oAP zebrafish quarantine facility
Recirculation and filtration systems to ensure
optimal environmental conditions
• Specialised aquatic animal husbandry staff
capabilities and services
• training in the use of zebrafish as a research
model
• Purchasing and agistment of zebrafish strains
• Zebrafish wild type, transgenic, and mutant
embryo production
• International and interstate importation and
AQIS-approved quarantining of zebrafish strains
• exportation of mutant and transgenic strains of
zebrafish
• Cryogenic freezing and rederivation of zebrafish
strains
staff
facility manager
Mr Julian Cocks
technicians
Mr eren Yilgor
Mr Rodney Glanvill
Mr Pitra Yudhyantara
Mr Maik Fiedel
Ms emma Carlos
Ms Jamie Mihelakos
Ms olivia Ferraro
Ms tanya Hynes
Ms natalie Bien-Izowski
Ms natalie Wong
www.monash.edu/research/infrastructure/
platforms/fishcore.html
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42
core research facILItIes
Gene Recombineering
the ARMI Gene Recombineering Facility provides
specialised modification of genomic material from
multiple organisms. Most constructs made are
targeting constructs and transgenic constructs.
Homologous recombination is used for construct
assembly. this enables the position of a DnA
construct to be altered, without having to rely on
restriction endonucleases.
the ARMI Gene Recombineering group works
closely with eS Cell Services and Monash Animal
Research Platform to offer a comprehensive design
and screening service.
• Construct design
• Southern screening strategy design (including
design of the southern probes)
• Shaving of BAC clones
• Subcloning pieces of BAC clones into high copy
plasmids
• BAC constructs (FlP lines, Cre lines, reporter
lines)
• Conditional knock out constructs
• Knock in constructs
• Promoter fusion constructs
• Introduction of point mutations
• Humanising animal models
• Construct cloning
staff
director
Ms Jeanette Rientjes
research assistants
Ms Margareta Go
Ms Susan thomas
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43
eS Cell Genetics Services
the ARMI Mouse embryonic Stem Cell Core
produces mouse eS cells with specific gene
modifications. the facility offers a range of
services, from electroporation of DnA constructs
into eS cells, to the identification of correctly
targeted clones.
Working closely with Monash Gene targeting
Facility (MGtF), the facility prepares eS cells for
microinjection and organises screening of the
chimeric mice generated, as well as analysis of
germ line transmission.
the facility collaborates with the Australian
Phenomics network in the production of chimeras
from eS cells obtained from the International
Knockout Mouse Consortium (IKMC).
•
•
•
•
electroporation of DnA constructs into eS cells
Screening the selected clones by Southern blot
thawing and expanding of the positive clones
Re-confirming by Southern blot the positive
clone and sequencing of important sites of
the mutated locus, such as loxPs, FRts and
eventual mutation knocked-in to the gene
• Preparation of eS cells for microinjection
• Screening of chimeric mice and germ line
transmission by PCR analysis
staff
manager
Dr Arianna nenci
research fellows
Dr Melissa Cooney
Dr Dirk truman
technical staff
Ms Wendy Chua
Page
44
ARMIRat
Researchers at the University of Southern
California (USC) recently demonstrated the only
proven and authentic germline competent rat
ES cell enabling technology that can use rats for
human disease modelling via precise genetic
engineering [Cell 2008: 135,1287; Nature 2010: 467,
211]. ARMIRat is an academic collaboration linking
the USC technology with advanced conditional
mutagenesis and animal modelling at ARMI.
It combines expertise in rat animal husbandry
and embryo manipulation (Monash Transgenic
Rodent Services), molecular biology and genetic
engineering (ARMI Gene Recombineering Core),
ES cell technology and expertise and broad
experience in derivation, maintenance and
manipulation of mammalian embryonic and
tissue-specific stem cells, and their differentiated
derivatives (ARMI and USC).
The outcome will be a platform with expertise
and capacity to provide transgenic rat services to
the life sciences community. It will be operated as
a service provided by ARMI on a fee-for-service
basis. The last two decades of life science has
witnessed a technological explosion in mouse
genetics and genomics, which promises to yield
a wealth of information on mammalian gene
function in ageing and disease. However, this
has shifted attention away from other valuable
mammalian models such as the rat. The larger
size and metabolic similarity to humans have
long made rats a preferred reference animal for
surgical interventions, physiological research and
pharmaceutical development. The initial rat models
generated will focus on two clinically relevant
models: hypertension and cardiac disease. Once
the technology is established, collaboration with
other groups will lead to new rat models to study
other diseases (for example, for diabetes and
atherosclerosis). The ARMIRat project commenced
in 2010 with technical expertise provided by
Jeanette Rientjes (Gene Recombineering), Dr
Arianna Nenci (ES Cell Services) and Dr Jose
Gonzalez (MGTF). Dr Nenci and Dr Gonzalez trained
with the USC team, Dr Qi-Long Ying and Dr Chang
Tong, on techniques to be adopted in the Transgenic
Rat Platform.
Support for the ARMIRat Project is provided by
the Victorian Department of Business and
Innovation and the Australian Department of
Health and Ageing.
Page
45
FlowCore
FlowCore is a purpose-built core facility providing
flow cytometry services to researchers from ARMI,
Monash university, the Australian Stem Cell Centre,
and the wider scientific community.
Flow cytometry is a high-speed laser-based
technology for analysing the characteristics of
cells, organisms and particles. Researchers tag
their samples with fluorescent probes, dyes or
proteins before running the samples through
multiple laser beams, exciting these probes.
the cytometer measures the light scatter and
fluorescence of the cells or particles, rapidly
generating multi-parametric data about the
size, complexity, protein expression and cellular
processes within the sample, on a cell-by-cell
basis. Samples can be sorted into sub-populations
based on these parameters, allowing researchers
to conduct experiments on pure populations of
cells or particles.
Flowcore is a PC2 certified facility run by four
full-time staff who provide quality controlled flow
cytometry experiments and expert advice, allowing
for better reproducibility of results and high quality
research. FlowCore also houses Australia’s first
five-laser cell sorter and seven-laser analyser,
allowing greater flexibility for researchers.
facilities
•
•
•
•
•
5 laser BD Influx cell sorter
4 laser BD Influx cell sorter
3 laser BD FACSVantage DiVA cell sorter
4 laser BD lSRII analyser
7 laser BD lSRII analyser
•
•
•
•
High-speed cell sorting
High-throughput flow cytometric analysis
training and education
Data analysis software
www.monash.edu/research/infrastructure/
platforms/flowcore.html
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46
Micromon
The Micromon High Next-Generation Sequencing
(NGS) Facility is the second longest running
Illumina NGS facility in Australia, offering
sequencing, bioinformatics, quantitative realtime PCR, acoustic shearing and nucleic acid
quantitation services. Utilising Illumina Genome
Analyzer GAllx, HiSeq and MiSeq sequencing
instruments, the facility can produce sequencing
data at up to approximately 16Gb per day. Micromon
can carry out a diverse range of applications
aside from standard DNA sequencing, such
as transcriptomics (RNA sequencing) for both
prokaryotic and eukaryotic organisms, small RNA
sequencing and discovery, DNA-protein interaction
studies, DNA methylation analysis, custom
amplicon sequencing and custom exome capture.
In addition to our sequencing capacity, we also
provide a nucleic acid, cell and tissue fragmentation
service based on the closed-vessel Covaris focused
acoustic shearing. Our nucleic acid quantitation
service is based on the the Agilent Bioanalyzer 2100
and Invitrogen Qubit system. Micromon services the
research needs of local, national and international
researchers.
In 2012 the team introduced new sequencing
instrumentation, capabilities and services based on
the Illumina HiSeq and MiSeq technology platforms.
This will improve sample throughput, decrease
sequencing costs, improve sample turn-around
time and increase data quality. Our quantitative
real-time PCR service also commenced in 2012
and this operates as a stand-alone service and also
as a complementary service to our RNA-seq NGS
application.
Micromon is involved with the Victorian Platform
Technologies Network, and was represented at
trade and scientific meetings to promote the service
to the broader scientific community.
Facilities
•
•
•
•
•
•
Illumina GAllx Genome Analyzer
Illumina MiSeq
Illumina HiSeq (outsourced)
Illumina Cluster Station
Covaris S2 focused acoustic shearing system
Agilent Bioanalyzer 2100
Capabilities and services
• Project scoping and pricing
• Sequencing library preparation
•Transcriptomics (mRNA sequencing, both
eukaryotic and prokaryotic)
• Small RNA sequencing and discovery
• DNA-protein interaction studies (ChIP-seq)
• Methylation analysis (Bisulphite sequencing)
• Bioinformatics
• Closed-cell nucleic acid, cell and tissue
shearing
• Quantitative real-time PCR
www.micromon.monash.org
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47
MMI is a core facility supporting research in the
life and biomedical sciences in all faculties and
associated research institutes at three Monash
university research precincts. there are four main
units: the Advanced optical Imaging Facility and
the BioeM Facility at the main Clayton campus,
and smaller advanced optical imaging nodes at
Monash Health translation Precinct (Clayton)
and the AMReP (Prahran). the Advanced optical
Imaging Facility is one of the largest in Australia
and is specially designed to support live cell and
functional imaging. In 2012, the BioeM Facility was
expanded to include a new CryoteM Ramaciotti
Centre for Structural Biology and it will bring
significant research capacity to cell and structural
biology for Monash university and other Victorian
universities.
facilities
• optical brightfield and fluorescence microscopy,
including polarisation microscopy
• Stereo /dissection microscope imaging in
brightfield and fluorescence modes
• large area imaging/whole slide scanning for
both brightfield and fluorescence
• Automated widefield optical microscopy, with
cell incubation capabilities for time-lapse
and live cell imaging. live cell microscopy is
supported further by an in-house tissue
culture facility
• Deconvolution microscopy
• Confocal microscopy; based on upright and
invert configurations, these systems have either
normal galvo scanning, or high-speed resonant
or spinning disk scanning, as well as xy and z
stage scanning
• Multiphoton microscopy: several instruments,
with upright configuration and heating
chambers are available for cell, tissue and small
animal work
• Fluorescence quantitation and imaging;
including specialised fluorescence
analytical techniques such as FRAP, FRet,
FCS, photoactivation, cell tracking and
multiparameter imaging (5D microscopy)
• Fluorescecence correlation spectroscopy
(FCS); FCS with sensitive single molecule
detection is coupled with a confocal/multiphoton
instrument, and cell incubation chamber
• Image analysis and visualisation laboratory;
providing a comprehensive range of 2D and
3D software including Imaris, Volocity and
MetaMorph
• transmission and Scanning electron
Microscopy; with associated specimen
preparation for resin sectioning and
ultramicrotomy, as well as Cryo-techniques
(high pressure freezing, freeze substitution, and
cryo- ultramicrotomy)
• ImmunoeM, and correlative microscopy,
including immuno-detection
• Imaging workshops for all of microscopy
modalities and image analysis
• Microscopy training in instrument operation,
research methods and analysis
• Provision of optical and electron Microscopes,
including operator training to self-use, for the
functional and structural analysis of living and
fixed tissues in two or more dimensions
• Planning and supervision of projects, including
general methodological approaches or specific
protocols and applications
• expertise and support in advanced optical
microscopy, including widefield fluorescence
and confocal microscopy, multiphoton
microscopy, automated and time-lapse imaging,
microscopy of live cells and tissues
• Correlative microscopy (extending optical
microscopy to the level of the eM for structure
or molecular localisation and identification)
• optimisation of specimen preparation,
immunolabelling, and staining for study by
optical and electron Microscopy
• live Cell Imaging expertise
• Image analysis, image reconstruction and
visualisation
• Research collaboration
www.microimaging.monash.org
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48
Structural Biology
Monash’s Structural Biology Platform
comprises two facilities: a state-of-the-art highthroughput protein crystallisation facility, and the
Macromolecular X-ray Diffraction Facility. Crystal
structures determined in the Facility can form the
basis of a wide range of biomedical science from
basic biology to the design of new pharmaceuticals.
During 2012 the Structural Biology Platform
was heavily used by structural biology research
laboratories within Monash University. This resulted
in a record number of crystals being grown, and the
determination of the crystal structures of targeted
biomedical macromolecules.
The Rigaku CrystalMation Robot system is a
fully integrated platform for macromolecular
crystallisation. Experiments are designed and
controlled using the sophisticated CrystalTrak
software package that also provides image analysis
tools. Two liquid-handling robots allow automated
preparation of custom crystallisation formulations
and setting-up of crystallisation trials. The plates
are subsequently transferred to temperaturecontrolled incubators where crystallisation drops
are automatically inspected for crystals and
photographed according to allocated schedules.
The researchers can access their results remotely
via a web-based interface.
This high-throughput crystallisation facility can
perform hundreds of crystallisation trials in a very
short time frame, using 96-well plate format, noncontact nano-dispensing and as little as 100 nL of
protein per plate. More than 5000 crystallisation
plates can be incubated simultaneously in 8
incubators. High quality crystals produced in the
Protein Crystallisation Facility can then be pipelined
into the Macromolecular X-ray Diffraction Facility.
Facilities
• Rigaku Crystalmation system
• Access to data analysis
• High flux microfocus X-ray generators each
equipped with confocal optics, cryocooling and
image plate detectors, all under computer
control
Capabilities and Services
• Automated screening of crystallisation
conditions
• Design of optimisation experiments
• Custom screen making and optimisation of
crystallisation experiments
• Crystal screening
• X-ray diffraction data collection
• Image storage and analysis
• Crystal structure determination
www.bioplatforms.monash.edu/bioplatforms/
structural-biology.html
Page
49
Monash Gene targeting Facility
the Monash Gene targeting Facility (MGtF) has
a proven capability in the creation of transgenic
rodent models through eS cell transfection and
DnA injection techniques including the use of BAC,
YAC and viral transgenesis. the facility is able to
provide additional advanced reproductive services
including Intracytoplasmic Sperm Injection (ICSI)
and in vitro fertilisation (IVF) procedures.
located within the facilities of the Monash Animal
Research Platform (MARP), MGtF conducts the
oocytes and blastocysts microinjections, embryo
transfer to foster mothers and breeding of progeny
to confirmed germ line transmission.
the Monash Gene targeting Facility works closely
with both the ARMI Gene Recombineering and the
Murine embryonic Stem Cell Services to provide a
comprehensive transgenic rodent production and
delivery service.
• Mouse eS cell injection into blastocysts and
breeding of pups to chimera or heterozygous
stage
• embryo pronuclear injection of DnA and rearing
of progeny to tg founders or germ line.
• Pronuclear injection of BAC or YAC (hybrid or
inbred strains) and rearing of tg founders to
germ line
• ICSI-sperm-mediated transgenesis oocyte
injection and rearing of tg founders to germ line
• ICSI and in vitro fertilisation and breeding of
progeny
group members
manager
Dr Jose Gonzalez
scientific officer
Dr Zhongtao Du
technical staff
Ms Jessica trollope (from october)
Page
50
core research facILItIes
Monash Antibody technologies Facility
Monash Antibody technologies Facility [MAtF)
uses advanced robotic platforms to produce
custom made, high quality, high affinity mouse or
rat monoclonal antibodies. using this technology,
MAtF has the capacity to provide thousands of
novel antibodies every year to a global clientele.
Primary screening is by MAtF’s proprietary
Antigen-MicroArray (AMA) technology, allowing
specific selection of IgG secreting clones. AMA
also enables screening against multiple proteins to
identify specific binding patterns, while significantly
reducing the amount of antigen required compared
with traditional methods.
facilities
•
•
•
•
•
•
10 tecan robotic platforms
Genetix ClonePixFl
Remp robotic freezer
BioRad Profiinia Purification System
ArrayJet Microarray Spotter
tecan Microarray Scanner
•
•
•
•
•
•
Custom monoclonal antibody generation
Cell line cloning and stabilisation
Antibody purification
Western blot
SPR analysis
elISA development
https://platforms.monash.edu/matf/
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51
Page
52
Governance
Page
53
Committees
Leadership advisory board
the ARMI leadership Advisory Board
(ARMIlAB) has an important role in helping the
Institute succeed in achieving its objectives and
strategic goals.
the lAB plays a supportive role in enhancing the
reputation and positioning of the Institute with key
stakeholders including business, government,
media and the broader community
Specifically, ARMIlAB works closely with senior
management to:
• promote the vision, role and accomplishments
of the Institute among business, government,
media and the broader community
• assist in the development of new ideas and
initiatives to support the objectives of the
Institute
• provide the Director and any steering bodies
with feedback from an external perspective of
the Institute.
the focus of ARMIlAB on contributing to
the Institute achieving its objectives will be
accomplished through:
• advocacy
• contributing experience and insight
• supporting and, where appropriate, mentoring
the Institute’s Director and its leadership
• supporting the Institute’s fundraising objectives
by assisting the Institute and Monash external
Relations, Development and Alumni (eRDA)
to build key philanthropic, donor and funding
relationships.
board members
Dr Janine Kirk, AM (Chair)
Dr Kirk, AM, is the lead Partner,
Government & Public Sector at
ernst & Young. Janine is also a
member of the ernst & Young
Area Advisory Board and Asia
Pacific Area Council, a director
of the ernst & Young Foundation and was recently
appointed leader, Community with responsibility
for eY’s community and social responsible activities
across Australia and new Zealand.
The Hon. Dr Kay Patterson
(Deputy Chair)
Dr Patterson was a Senator
for Victoria for 21 years. Prior
to entering the Senate, Dr
Patterson managed a small
business before attending
university and attaining a PhD in Psychology. She
taught at Sydney and Monash universities and held
senior academic positions, including Chairman of
the School of Behavioural Sciences at the lincoln
Institute of Health Sciences (now at la trobe
university).
The Hon. John Brumby
the Hon. John Brumby was
Premier of Victoria from 2007
to 2010 and has immense
experience in public life. He
served for more than ten
years as treasurer and then
Premier of Victoria, six years as leader of the
Victorian opposition and seven years as Federal
MHR for Bendigo during the period of the Hawke
Government.
Mr Andrew Dyer
Mr Dyer is Chairman of the
telecommunications Industry
ombudsman Council and ItSS,
and serves on the boards of the
transport Accident Commission,
BrightSource energy Australia,
the American Australian Association, the Australian
Solar energy Society and the Good Foundation.
Page
54
Governance
Ms Elizabeth Matthews
Ms Matthews has retired from
a 20-year legal career with
Corrs Chambers Westgarth,
where she spent most of her
years as a commercial litigator
before progressing into internal
management positions. For the two years prior
to her retirement, Ms Matthews was the National
Manager of Legal Support. Ms Matthews now
works in a volunteer capacity in the Melbourne
County Court with Court Network.
Mr Tim Murphy
Mr Murphy has held senior roles
across a range of industries in
the public and private sectors
from the Federal Government
to pharmaceutical, medical
research and biotechnology to
higher education, arts and tourism.
Dr Zita Unger
Dr Unger has a distinguished
career spanning 15 years
as an evaluator, educator
and entrepreneur, drawing
on extensive knowledge of
organisational development,
business acumen and governance to bring valuable
contributions at the board level. She gained her
doctorate in Sociology of Education at the University
of Melbourne.
(Executive Member)
Professor Rosenthal is the
founding director of ARMI.
Professor Rosenthal was
previously Head of the European
Molecular Biology Laboratory in
Monterotondo (Rome) Italy, where she directed the
EMBL Mouse Biology Program. She also holds a
visiting professorship at the University of Western
Australia. She has served on numerous study
sections, advisory panels and editorial boards
including the New England Journal of Medicine,
where she was Consultant of Molecular Medicine.
Mr Michael Spiegel
(Executive Secretary)
Mr Spiegel is the Head, Strategic
Development, and Executive
Secretary of the Leadership
Advisory Board for ARMI
and director and founder of
Mirrorcone Pty Ltd. Mr Spiegel joined ARMI in
September of 2009 after co-founding and running
the Monash Antibody Technologies Facility, one
of the world’s most sophisticated and automated
novel antibody facilities.
Group Leaders (ARMI Faculty)
Committee Membership
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Dr James Bourne
Professor Peter Currie
Associate Professor Tiziano Barberi
Dr Julian Heng (Deputy Chair)
Dr Jan Kaslin
Professor Graham Lieschke (Chair)
Professor Christophe Marcelle
Dr Edwina McGlinn
Dr Nicolas Plachta
Mr Silvio Tiziani
Dr Claude Bernard (from Sept 2012)
Dr Jose Polo (from April 2012)
Dr Robin Hobbs (from Feb 2012)
Meeting Dates
24 February
30 March
27 April
25 May
29 June
27 July
31 August
28 September
26 October
7 December
Page
55
safety committee
scientific services committee
committee membership
•
•
•
•
•
•
• Ms Renae Hayle (Chair), Manager, Resources
and Scientific Services
• Ms Barb Bethune, technical officer, Scientific
Services
• Ms Simone Heane, Secretary
• Dr Gurpreet Kaur
• Mr William Kwan
• Dr Joly Kwek (until March 2012)
• Mr Joseph Chen (from June 2012)
• Dr olivier Serralbo
• Ms Carmen Sonntag
• Mr Zhengdong Qu
• Ms Sony Varma
• Dr lina Wang
• Ms Krutika Wikhe (until June)
• Ms lisa Wong
• Ms Mia De Seram (from August)
• Ms Jean tang (from August)
• Dr Melissa Cooney, eS Cell Services (alternate)
• Ms Jeanette Rientjes, Gene Recombineering
(alternate)
•
•
•
•
•
Ms Renae Hayle (Chair)
Ms Simone Heane (Secretary)
Dr lina Wang, Biosafety officer
Mr William Kwan, First Aid Coordinator
Dr Arianna nenci, Radiation Safety officer
Dr Dirk truman, Alternate Radiation Safety
officer
Mr Silvio tiziani, Chief operating officer
Mr Julian Cocks, Aquarium Manager
Mr David Hurst, Faculty oHS consultant
Mr Wouter Masselink, Student representative
(until April 2012)
Mr Ivan ng, Student representative
(from July 2012)
terms of reference
the committee helps implement new safety
regulations handed down by the Monash
occupational Health and Safety group and tries to
ensure a safe working environment at ARMI. the
Safety Committee comprises a critical element
of ARMI’s Safety System, helping to ensure the
Institute has a safe working environment and
complies with relevant university and legislative
requirements.
2012 highlights
the committee focused this year on the university’s
oHS Strategic Plan, which involved providing
training of all new staff and post graduate
students in:
• Biosafety Module 1 (Microbiology)
• Biosafety Module 2 (oGtR/AQIS).
the committee also organised training for new
fire wardens and the flu vaccination for staff. two
laboratory safety computers were also installed
to enable ARMI staff and students to find safety
documentation quickly and without having to leave
the lab area.
meeting dates
21 February
20 March
24 April
24 July
18 September
20 november
terms of reference
the role of this committee is to discuss matters
including equipment requirements, laboratory
issues, purchasing of laboratory consumables and
reagents, and to determine ways to put into practice
any new scientific requirements.
2012 highlights
throughout the year the committee was involved
in the purchase and maintenance of shared
laboratory equipment. they also set new guidelines
for the use of communal areas and helped with the
integration of a new lab group into the north shared
laboratory space.
they were integral in updating the chemical
database of each lab group and with the help of the
workshop, developed a safer way to use a new piece
of laboratory equipment.
lastly, the committee was vital in helping to
maintain the laboratory equipment through a
system of shared responsibility.
meeting dates
7 February
28 March
6 June
15 August
10 october
Page
56
Governance
Scientific Advisory Committee
Meeting Dates
Professor Dame Kay Davies, DBE, FMedSci, FRS,
University of Oxford
19 January
16 February
Professor Sir Magdi Yacoub, FRCS, FRS, Imperial
College London and Harefield Heart Science Centre
The composition of the FishCore Management
Committee was changed during the year to
incorporate more feedback from the users of the
facility. The committee is now called the FishCore
User Group.
Professor Peter Rigby, FRS, FMedSci, The Institute
of Cancer Research, UK
Professor Eric Olson, University of Texas
Southwestern Medical Center, Dallas, USA
Professor Nadia Rosenthal, ARMI and EMBL
Australia
Mr Silvio Tiziani, ARMI and EMBL Australia
Terms of Reference
The Committee provides advice to the Director, in
particular with regard to scientific proposals and
on the preparation and realisation of the scientific
programme of the Institute. It performs its task
in due cooperation and in consultation with the
Director, seeking the advice of experts where
appropriate.
Highlights
Members of the Committee met for the first time
as a group during the Scientific Retreat in May
to review progress with the Institute and make
recommendations on future scientific directions
including recruitment.
FishCore Management Committee/
FishCore User Group
FishCore Management Committee
Membership
•
•
•
•
•
•
Professor Graham Lieschke (Chair)
Professor Peter Currie
Mr Julian Cocks
Dr Jan Kaslin
Dr Heather Verkade (Faculty of Science)
Dr Robert Bryson-Richardson (Faculty of
Science)
Terms of Reference
The Committee is responsible for overseeing the
facility. It works with management to ensure a
technically proficient and sustainable facility that
meets the needs of researchers.
FishCore User Group Membership
• Mr Julian Cocks (Chair)
• Mr Rodney Glanvill
• Ms Kym Grundy (until July)
• Mr Pitra Yudhyantara
• Ms Sony Varma
•Evelyn Yip
• Aminah Griousoh
• Raquel Vaz
• Mo Zhao
• Ms Carmen Sonntag
• Brendan Wilding
• Mr Eren Yilgor
• Dr Milena Furtado
• Dr Jan Kaslin
• Mr Wade Moore
• Dr Patricia Jusuf
Meeting Dates
17 August
12 October
9 November
7 December
2012 Highlights
• A new meeting format led to improved
communication and synergy between FishCore
staff and researchers.
• Incentives were introduced to reduce labour,
energy and water waste through a conscious
strategy to use appropriately sized fish holding
tanks for individual research projects.
• FishCore management and procedures were
simplified to provide researchers with better
services.
Page
57
higher degree by research (hdr)
committee
the HDR program has continued to develop since
its inception in 2011. PhD student enrolments rose
from six to eleven.
In 2012, ARMI continued to attract Honours
students with six students enrolling.
undergraduate students had the opportunity to
undertake research projects as either vacation
scholarships students or via the “research in
action” unit, highlighting ARMI’s commitment to
contribute to undergraduate teaching.
the HDR Committee continues to provide support
to the students and information and advice to the
ARMI Faculty.
• Associate Professor James Bourne, HDR
Coordinator (Chair)
• Ms Jane McCausland, Student Programs
Coordinator
• Professor Graham lieschke, Faculty member
• Dr edwina McGlinn, eMBl Australia Group
leader
• Dr Mauro Da Costa, Honours representative
• Dr Cristina Keightley, uRoP Coordinator
• Mr Wouter Masselink, PhD student
representative
• Mr Silvio tiziani, Chief operating officer
executive hdr committee membership
• Associate Professor James Bourne, HDR
Coordinator (Chair)
• Ms Jane McCausland, Student Programs
Coordinator
• Professor Graham lieschke, Faculty member
• Dr edwina McGlinn, eMBl Australia Group
leader
terms of reference
the role of the ARMI HDR Committee is to provide
independent guidance, support and mentoring to
research students, supervisors and members of
the institute.
the role of the executive committee is to handle
issues pertaining to the recruitment of students,
ranking of scholarship applications, progress of
students and issues of a confidential nature in
relation to HDR coordination.
2012 highlights
All students participated in the ARMI Scientific
retreat held in May with a poster presentation of
their research.
the students in ARMI’s inaugural PhD cohort
all successfully achieved their confirmation of
candidature.
All the Honours students achieved an H1, with
special mention to linh ngo who received an
award from the Department of Anatomy and
Developmental Biology as the top overall BMS and
Science Honours student.
A student lunch was held to celebrate the launch of
the student committee.
meeting dates
9 February
1 March
10 May
31 May (Student meeting)
5 July
3 August (Individual meeting with HDR Coordinator)
4 october
19 november (executive HDR Committee)
Page
58
governance
ARMI team
office of the director
Mr Silvio tiziani, Chief operating officer
Ms Barbara Bethune, technical officer, Scientific
Services
Ms laura Crilley, executive officer
Ms Renae Hayle, Manager, Resources and Scientific
Services
Ms Simone Heane, Administrative Assistant
Ms Penny Rowlett, Finance officer
Ms lisa Ryan, executive Assistant, eMBl Australia
(until June)
Ms Jane McCausland, Student Program
Coordinator
Mr Mike Spiegel, Head of Strategic Development
Ms Michelle Ahlquist, executive Assistant
(from August)
core facilities
es cell genetics services
Dr Arianna nenci, Manager
Ms Wendy Chua, Research Assistant
Dr Melissa Cooney, Research Assistant
Dr Dirk truman, Research Fellow
fishcore
Mr Julian Cocks, Aquarium Manager
Mr eren Yilgor, Aquarium technician
Mr Rodney Glanvill, Aquarium technician
Mr Pitra Yudhyantara, Aquarium technician
Ms Kim Grundy (until August)
Mr Maik Fiedel
Ms emma Carlos
Ms Jamie Mihelakos
Ms olivia Ferraro
Ms tanya Hynes
Ms natalie Bien-Izowski
Ms natalie Wong
gene recombineering
Ms Jeanette Rientjes, Director
Ms Margareta Go, Research Assistant
Ms Susan thomas, Research Assistant
research groups
barberi group
Associate Professor tiziano Barberi, Group leader
Dr Isabella Mengarelli, Research Fellow
(until September)
Ms Bianca Borchin, PhD student (from January)
Mr Joseph Chen, Research Assistant (from March)
bourne group
Dr James Bourne, Group leader
Dr Jihane Homman-ludiye, Research Fellow
Mr William Kwan, Research Assistant
Mr leon teo, PhD student
Ms Claire Warner, PhD student
Ms Skye Kinder, Honours student
Dr tobias Merson, ARMI affiliate
Professor Anita Hendricksen, ARMI affiliate
Dr Julie thacker, ARMI affiliate (from June 2012)
currie group
Professor Peter Currie, Deputy Director,
Group leader
Dr Joachim Berger, Research Fellow
Ms Silke Berger, Research Assistant
Dr Catherine Boisvert, Research Fellow
Ms ophelia ehrlich, PhD student
Dr Yona Goldshmit, Research Fellow
Mr David Gurevich, PhD student
Dr tom Hall, Research Fellow (until January)
Dr Patricia Jusuf, Research Fellow
Mr Zhenhua li, PhD student (from March)
Mr Wouter Masselink, PhD student
Mr Phong nguyen, PhD student
Ms Carmen Sonntag, Research Assistant
Page
59
heng group
Dr Julian Heng, Group leader
Dr Matilda Haas, Research Fellow
Mr Ivan ng, PhD student
Mr Zhengdong Qu, Research Assistant
Ms Shanshan li, Research Fellow
Ms linh ngo, Honours student
hobbs group
Dr Robin Hobbs, Group leader
Ms Mia De Seram, Research Assistant (from June)
Lieschke group
Professor Graham lieschke, Group leader
Dr Felix ellett, Research Fellow
Dr Cristina Keightley, Research Fellow
Ms Sony Varma, Senior Research Assistant
Mr Sultan Alasmari, PhD student (from october)
Mr Vahid Pazhakh, PhD student (from november)
Ms emily Scott, uRoP student (from July)
Dr Chieh-Huei Wang, Research Fellow
(from october)
Mr Johannes Wittig, Visiting student (from August)
kaslin group
Dr Jan Kaslin, Group leader
Ms Krutika Wikhe, Research Assistant (until June)
Ms Frisca Frisca, Visiting PhD student
(from September)
Ms Jean tang, Research Assistant
Mr Sunil Kumar, Casual Research Assistant
(from August)
Mr Raphael Park Chae, Casual Research Assistant
(from January)
Ms Celia Vandestadt, uRoP student (from January)
marcelle group
Professor Christophe Marcelle, Group leader
Dr David Salgado, adjunct Research Fellow
(from August)
Dr olivier Serralbo, Research Fellow
Mr Cyril Picard, PhD student/Research Assistant
(from october)
Dr Manuel Pele, Adjunct Research Fellow
(from July)
Dr Anne Rios, Research Fellow/ARMI Affiliate
Mr Daniel Seiero Mosti, PhD student
Dr Ashvind Prabahran, Research Fellow/ARMI
Affiliate (until September)
Mr Jeremy ng Chi Kei, Honours student
Ms nadege Veron, Research Assistant
Mr Mark Sedrak, uRoP student
Dr Federico Calhabeu, Research Fellow (from April)
Dr Claire Hirst, Research Fellow (from September)
mcglinn group
Dr edwina McGlinn, Group leader
Dr Alysha Heimberg, Research Fellow
Ms lisa Wong, Research Assistant
Mr eamon Coughlin, PhD student
Dr Jesus Casanova, Research Fellow (from July)
Mr Janus Jacobsen, ARMI affiliate
(from January to July)
plachta group
Dr nicolas Plachta, Group leader
Dr Gurpreet Kaur, Research Fellow
Mr Juan Silva, Research Assistant
Dr Juan Gonzalez, Research Fellow (from March)
Dr Melanie White, Research Fellow (from May)
Dr Jennifer Zenker, Research Fellow
(from December)
polo group
Dr Jose Polo, Group leader
Dr Sue Mei lim, Research Fellow
Dr Christian nefzger, Research Fellow
Sara Alaei, PhD student
Jaber Firas, undergraduate student
rosenthal group
Professor nadia Rosenthal, Group leader/Director,
ARMI
Dr Minna-liisa Anko, Research Fellow/ARMI
Affiliate
Dr Mauro Costa, Research Fellow
Dr Milena Furtado, Research Fellow
Dr James Godwin, Research Fellow
Mr nicholas lam, Research Fellow/ARMI Affiliate
Dr ekaterina Salimova, Research Fellow (from July)
Dr Alex Pinto, Research Fellow
Ms Joelle Perera, Honours student
Dr lina Wang, Research Fellow
Mr Drew Kuraitis, visiting student/ARMI Affiliate
(from September)
Ms Anjana Chandran, Research Assistant
Page
60
governance
nationalities
AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTIN
AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SING
ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRA
SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH
ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGL
INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLAD
BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZE
CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GER
ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MA
GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN
MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE A
AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTI
TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAY
IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI S
SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CH
SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND
JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN DANISH HUN
ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SI
CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLA
SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH USA ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN
HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRAL
MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA
AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH ISRAELI M
JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN ISRA
IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SE
TAIWAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH
TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAY
JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANI
ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREA
HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWE
BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAME
ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN B
BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAM
SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH A
VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA F
AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTI
TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK BRAZIL ENGLAND ISRAE
ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISR
MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BR
BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAME
IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENC
VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRAN
GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANI
BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIW
IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SE
SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CH
RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK
CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CU
ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN B
BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAM
SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH A
VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRAN
STAFF AND STUDENTS IN 2012 CONSISTED OF
32 DIFFERENT NATIONALITIES…
…AND WERE RECRUITED FROM
19 DIFFERENT COUNTRIES
Page
61
NIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN
GAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN IT
AELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DE
H INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CA
LADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALA
DESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GE
EALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN M
RMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIA
ALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRAL
N AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FI
AUSTRALIA USA FRANCE SWEDEN ITALY JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN
INIAN FINNISH INDONESIAN DENMARK IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI M
YSIA SINGAPORE SPAIN TAIWAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH
SERBIAN TAIWANESE HOLLAND AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND
HINESE JAPANESE ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNG
ISRAEL MALAYSIA DENMARK GERMANY SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRI
NGARIAN UK ISRAELI MALAYSIAN SWITZERLAND RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN
SINGAPOREAN HOLLAND DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VI
LAND ENGLAND SWEDEN UK GERMANY BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN FRENCH A
MEXICAN VIETNAMESE SWITZERLAND CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FR
LIAN SAUDI FRANCE AMERICAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDO
A USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA JAPAN SWITZERLAND TAIWA
MALAYSIAN IRANIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE A
AELI SPAIN AUSTRALIAN ITALY FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH
ERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAY
H ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI M
YSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER TAIWAN INDIAN SINGAPOREAN BRI
ISH HUNGARIAN ISRAELI MALAYSIAN RUSSIANSERBIAN IRAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN U
AN BRITISH DUTCH INDIAN ITALIAN ISRAEL JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BAN
EDEN UK BANGLADESH DENMARK ENGLAND MALAYSIA SINGAPORE BANGLADESH SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERM
ESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN
BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BAN
EDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERM
MESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRA
AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IR
FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK SINGAPORE ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN
INIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN MALAYSIA CUBAN DANISH HUNGARIAN ISRAELI M
EL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN I
RAELI MALAYSIAN RUSSIAN SAUDI SERBIAN ISRAELI TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANG
RITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANG
ESE BANGLADESHI CANADIAN CUBAN DANISH SERBIAN HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITAL
CH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IR
NCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIW
IAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWA
WAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH
ERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL NEW Z
HINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BANGLADESHI CANADIAN CUBAN DAN
K ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWAN AUSTRALIAN AUSTRALIAN FRENCH AMERICAN GERMAN NEW ZEALANDER SINGAPOR
UBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN
BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IRANIAN ISRAELI MALAYSIAN MEXICAN VIETNAMESE BAN
MESE BANGLADESHI CANADIAN CUBAN DANISH HUNGARIAN ISRAELI MALAYSIAN RUSSIAN SAUDI SERBIAN TAIWANESE AUSTRALIA USA FRANCE ITALY BRA
AMERICAN GERMAN NEW ZEALANDER SINGAPOREAN BRITISH DUTCH INDIAN ITALIAN CHINESE JAPANESE SPANISH ARGENTINIAN FINNISH INDONESIAN IR
NCE ITALY BRAZIL JAPAN GERMANY HOLLAND IRAN SWEDEN UK BANGLADESH DENMARK ENGLAND ISRAEL MALAYSIA SINGAPORE SPAIN SWITZERLAND TAIWA
Page
62
Financials
Page
63
ARMI Financial Report 2012
2012
2011
2010
2009
($,000)
($,000)
($,000)
($,000)
4,831
4,090
1,363
1,192
307
398
318
349
1,205
861
581
620
308
0
0
0
2,885
4,047
3,432
2,404
70
67
332
196
9,607
9,464
6,409
4,761
7,193
6,353
4,939
3,267
note
Income
Research Grants
Donations
Fee-for-service
IGS/RIBG & research support
teaching
FMnHS & DVC(R) contribution
1
DVC(R) Advance on 2011
other Income
total Income
383
Salary Expenditure
total Salary expenditure
Non-salary Expenditure
1
Capital expenditure
88
20
44
66
Book & library
17
9
14
5
-25
-12
59
22
Communications Related
77
73
145
154
Computer Related
35
39
86
78
equipment Related
73
122
-31
56
Finance & Admin
29
21
21
9
1,502
921
810
721
5
9
9
9
54
90
72
58
Building & Property
lab & operating
Motor Vehicle
Print & Stationery
Staff Related
73
-77
4
214
Student Scholarship
232
158
31
7
travel Related
360
318
245
187
other expenses
111
68
-31
81
2,630
1,757
1,477
1,667
9,823
8,110
6,416
4,934
Net Operating Result
-216
1354
-8
-172
Previous Year Carry forward
1133
-221
-213
137
917
1133
-221
-36
total non-salary expenditure
Total Expenditure
Closing Balance
notes
1 Does not include central services overheads (e.g. HR, Finance, It and space/rental)
2 Cost recoveries
3 2010 Carry forward adjusted from 2009 close
2
2
2
2
3
Page
64
Activities
Page
65
visitors
ARMI hosted visitors from international and
Australian organisations. ARMI also welcomed
many visitors who presented seminars during
2012—see external Seminar Series (below).
february
Professor Hiroaki Kitano visited 12–13 March 2012,
during his visit for the signing of an Mou with eMBl
Australia, and met with ARMI researchers from the
Rosenthal and Plachta Groups to discuss potential
collaborations.
june
A delegation from King Abdulaziz university, Saudi
Arabia, visited and toured ARMI, hosted by Mr
Silvio tiziani. the delegation included Professor
Abdulmonem Al-Hayani, Secretary Medical Deans
Committee and Vice Dean for Basic Medical
Sciences.
july
A delegation from the Monash university Medical
Foundation (MuMF) visited and toured ARMI, hosted
by Professor Peter Currie. the delegation included:
• Dr lara Grollo
• Mr Jeremy nestel
• Mr lewis Johnston.
A delegation by Southeast university China (Monash
university’s Graduate School in China) visited ARMI,
hosted by Professor Peter Currie.
Dr Silke Schumacher of eMBl, Heidelberg,
visited the eMBl Australia secretariat office at
ARMI and met with Mr Silvio tiziani, executive
Director, and Group leaders Dr nico Plachta and
Dr eddy McGlinn.
A delegation from underworks Pty ltd and executive
Compass Management Consultants visited and
toured ARMI, hosted by Professor Peter Currie. the
delegation included:
• Mr Sam, Managing Director, underworks Pty ltd
• Dr Dan evans, Founder and Principal, executive
Compass Management Consultants.
A delegation from the university of Warwick,
uK, visited and toured ARMI, hosted by
Mr Michael Spiegel.
the delegation included:
• Sir George Cox, Pro Chancellor, university of
Warwick
• Professor tim Jones, Pro Vice-Chancellor,
Knowledge transfer and Business engagement
and Research (Science and Medicine)
• Professor Peter Winstanley, Dean of Medicine.
august
Dr Matthias Hentze, Associate Director, eMBl
hosted by Mr Silvio tiziani, visited and toured ARMI
& eMBl Australia.
A delegation from technion, Israel Institute of
technology, visited and toured ARMI, hosted by
Professor Peter Currie. the delegation included
Professor Peretz lavie, President, technion, Israel
Institute of techology.
Professor Jussi Helppi, Head of Biomedical Servies
and Facilities, Max Planck Institute of Molecular
Cell Biology and Genetics, Germany, visited and
toured ARMI. He also gave a presentation (see
external Seminars).
september
A delegation from the national Research
Foundation, uAe, visited and toured ARMI. the
delegation included:
• Dr Ahmed Alosi, Research Program Manager
• Dr Husam Sultan Al-ulama, Director.
october
A delegation from Dammam university, Saudi
Arabia, visited and toured ARMI and FishCore,
hosted by Mr Silvio tiziani. the delegation included:
• Alsultan, Ali Ibrahim, Dean of the College of
Medicine
• Motabagani, Mohamedakram Hassan,
Chairman of Curriculum Committee, Anatomy
• Al elq, Abdulmohsen Habib, Member of
Curriculum Committee, Internal Medicine
• Sebiany, Abdulaziz Mohammed, Member of
Curriculum Committee, Family and Community
Medicine
• Alshaikh, Mona Hammoud, Member of
Curriculum Committee, Physiology.
Page
66
Activities
Events
February
August
John Brumby, former Victorian Premier and
ARMI board member, published an opinion piece
“Zebrafish help put us ahead of pack” in The Age 28
March (http://www.theage.com.au/federal-politics/
society-and-culture/zebrafish-help-put-us-aheadof-pack-20120327-1vwfa.html).
ARMI hosted a Next-Generation Sequencing
Bioinformatics Workshop, which was organised
by AGRF and EMBL Australia. The workshop gave
biologists who are new to analysing Next-Gen
Sequencing data a snapshot of bioinformatics and
data analysis.
March
Monash IVF, ARMI and the Systems Biology
Institute Workshop. Researchers from ARMI and
Monash IVF explored collaborative opportunities
arising from the research conducted by Dr Nico
Plachta and Professor Hiroaki Kitano.
A Memorandum of Understanding (MOU) was
signed with SBI and Monash University by Professor
Hiroaki Kitano (SBI) and Professor Richard Larkins
(Monash University) at the Melbourne Convention
and Exhibition Centre.
April
Mr Silvio Tiziani and Dr Sarah Boyd gave a
presentation to the Defence Science and Technology
Organisation (DSTO) at Fisherman’s Bend.
They explained the background to SBI Australia
and EMBL Australia and discussed possible
collaborations and linkages with DSTO.
May–June
ARMI research staff attended a Scientific Retreat at
Silverwater Resort, near Phillip Island.
The retreat was attended by two members of the
ARMI Scientific Advisory Committee, Professor
Peter Rigby, Royal Cancer Hospital, London, and
Professor Dame Kay Davies, University of Oxford.
July
ARMI hosted a TEAM VIC (Tissue Engineering and
Matrix Group of Victoria) seminar on Cell Therapy,
supported by CSIRO and the Small Technologies
Cluster:
• Dr David James, Senior Director, Life Sciences
and Pharmaceutical, Invetech Pty Ltd, spoke on
“Cell Therapy: Commercialisation—Creating a
Roadmap for Success”.
• Dr Ray Wood, Managing Director, Cell Therapies
Pty Ltd, spoke on “Research Translation: from
Bench to Clinic and Beyond—the regulatory and
cGMP requirements”.
October
A delegation from Monash/ARMI visited Japan for
signing of agreement with SBI. Delegates included:
• Professor Edwina Cornish, Senior Deputy
Vice-Chancellor and DVC (Research) , Monash
University
• Dr Sarah Boyd, ARMI
• Mr Silvio Tiziani, ARMI
• Professor Paul Bonnington, Director,
e-Research, Monash University
• Mr Steve Quenette, Maths, Monash University
• Professor Kerry Hourigan, Director, Division of
Biological Engineering, Monash University
• Professor Nadia Rosenthal, Director, ARMI.
November
ARMI hosted a TEAM VIC (Tissue Engineering and
Matrix Group of Victoria) seminar on Neural Repair,
supported by Monash University and the Small
Technologies Cluster. Speakers included:
• Dr James Bourne, Group Leader ARMI, Monash
University, on “Models of Injury in the Non
Human Primate: A new Era for Treatment
Strategies”
• Associate Professor John Forsythe, Department
of Engineering, Monash University, on “Neural
Engineering Solutions for Brain Repair”
• Professor Jeffrey Rosenfeld, Department
of Surgery, Central Clinical School, Monash
University, on “Bringing New Brain Injury
Treatments to the Clinic”.
Page
67
armI in the news
Page
68
actIvItIes
external seminar series
january
june
Professor Patrick tam, embryology unit, Sydney
Medical School, university of Sydney: “Intersection
of transcriptional and signalling activity for tissue
morphogenesis in mouse embryos”
Professor John Mattick, executive Director,
the Garvan Institute of Medical Research, Sydney:
“RnA at the epicentre of human development”
march
Professor Greg Stuart, the John Curtin School of
Medical Research, Canberra: “How input from the
eyes is processed by the brain”
Professor Justin Cooper-White, Australian Institute
for Bioengineering and nanotechnology, university
of Queensland: “tailored surfaces, scaffolds and
diagnostic cell-based microfluidic platforms for
small molecule screening, stem cell expansion and
controlled tissue genesis”
Professor Francis Stewart, tu Dresden, Germany:
“Reprogramming of the epigenome during early
mouse development”
Dr James Briscoe, Division of Development
neurobiology, national Institute for Medical
Research, london: “the Gene Regulatory logic of
Sonic Hedgehog Morphogen Signalling”
may
july
august
Professor Hiroaki Kitano, the Systems Biology
Institute, tokyo, Japan: “Act Beyond Borders”
Professor Melissa little, IMB Kidney Research
laboratory, the university of Queensland: “the
Kidney from morphogenesis to regeneration and
back again”
Dr Jussi Helppi, Head of Biomedical Services,
Max Planck Institute of Molecular Cell Biology and
Genetics: “Centralised core services and facilities is
the key for success”
Dr Sam Wormald, Cell and Molecular Biology
laboratory, WeHI Systems Biology & Personalised
Medicine: “Systematic mapping of genetic
interaction networks governing embryonic stem
cell self-renewal”
september
Dr Judith Anderson, Professor and Head of
Department of Biological Sciences, university of
Manitoba, Canada: “Muscle Regeneration from
Finish to Start, and Back”
Associate Professor Gary Hime, Dept of Anatomy
& neuroscience, university of Melbourne: “Genetic
analysis of the regulation of stem cell differentiation
by transcriptional and translational repressors”
Dr Karina Yaniv, Weizmann Institute, Israel:
“Fishing for novel Regulators of Developmental
Angiogenesis”
Professor eldad tzahor, Weizmann Institute,
Israel: “Head & Heart Muscle Development and
Regeneration”
Dr Vladimi Korzh, Institute of Molecular and Cell
Biology, A*StAR, Singapore: “Mechanisms of
late neurulation as reflected by the roof plate
development”
Dr natasha Harvey, Centre for Cancer Biology,
lymphatic Development lab, SA Pathology:
“lymphatic Vascular Morphogenesis—From
Progenitor Cells to Functional Vessels”
october
Professor Miranda Grounds, School of Anatomy and
Human Biology, university of Western Australia:
“From Symbiosis to Sarcopenia: around 40 years of
Skeletal Muscle Research”
november
Dr Karuna Sampath, Dept of Biological Sciences,
national university of Singapore, Singapore:
“Maternal Control of embryogenesis”
Page
69
Internal seminar series
For 2012 the ARMI external Speaker Series was expanded to include presenters from other units located
in Building 75, including the Monash Immunology and Stem Cell laboratories (MISCl), as well as CSIRo.
these groups include close colleagues and collaborators to ARMI and their inclusion in the seminar series
helped to identify additional collaborative opportunities.
Presenter
Designation
Seminar Date
Presentation Title
Professor Francis
Stewart
Special Speaker
7 March
Reprogramming of the epigenome during
early mouse development
Dr Juan Carlos
Fierro-Gonzalez
Research Fellow
14 March
How tRX-1 contributes to maintaining
survival in Caenorhabditis elegans
Dr Joachim Berger
Postdoctoral
Fellow
14 March
Identification and Characterisation of a
Zebrafish Chaperonin Mutant
Dr Cristina Keightley
Research Fellow
4 April
unravelling the role of ZBtB11 in
haematopoiesis
Dr Robin Hobbs
Group leader
11 April
transcription factor networks underlying
germline development, maintenance and
cancer
Dr Julian Heng
Group leader
18 April
understanding the neurobiology of
intellectual disability to improve neuroregenerative medicine
Dr James Godwin
Senior Research
Fellow
2 May
Adult salamander regeneration is
immunologically regulated
Dr Graham lieschke
Group leader
9 May
Imaging inflammation in vivo in zebrafish
Professor nadia
Rosenthal
Group leader
16 May
Immune modulation of regeneration
Dr Matilda Haas
Research Fellow
23 May
Genetic control of cerebral cortex
development and maturation
Dr Scott Coutts
Genomic
Sequencing
23 May
Micromon, the Monash university DnA
Sequencing Core Facility: Services,
Applications and Access
Dr James Bourne
Group leader
6 June
Mapping neuroplasticity in the visual
system
Dr Mauro da Costa
Research Fellow
20 June
of mice and man: deciphering nKX2-5
function in cardiomyopathy
Dr edwina McGlinn
Group leader
27 June
lineage specific regulation of Hox output by
microRnAs
Ms Jessica Morison
PhD Student
4 July
the immunogenicity of stem cells and
thymus-based strategies to minimise
immune rejection.
Dr Roland (Runzhe)
Shu
Research Fellow
18 July
APP biology in neural stem cell
differentiation and AD pathology
Dr nicolas Plachta
Group leader
25 July
Imaging mammalian development
Professor Peter
Currie
Group leader
1 August
Modelling muscle disease and regeneration
in zebrafish
Page
70
Activities
Internal Seminar Series (cont)
Presenter
Designation
Seminar Date
Presentation Title
Dr Chris Siatskas
Research Fellow
8 August
MSCs, the good the bad and the ugly
Dr Mauro Costa
Research Fellow
8 August
Generation and characterisation of human
embryonic set cell-derived endothelial cells
(hESC-ECs)
Dr Catherine Boivert
Research Fellow
15 August
Evolution of myogenesis in vertebrates:
Insights from the Elephant shark
Dr Tracy Heng
Research Fellow
29 August
How do multipotent mesenchymal
stromal cells inhibit allergic airway
hyperresponsiveness?
Dr Andrew Holland
Research Fellow
29 August
Pathways to Pancreas
Associate Professor
Tiziano Barberi
Group Leader
5 September
The directed differentiation of human
pluripotent stem cells.
Dr Yona Goldshmit
Research Fellow
12 September
Blocking Lysophosphatidic acid (LPA) after
spinal cord injury improves outcome
Professor Sharon
Ricardo
Group Leader
12 September
Cellular-based therapies for kidney
regeneration and repair
Dr Jose Polo
Group Leader
26 September
Unveiling the reprogramming process
Dr Patricia Jusuf
Research Fellow
3 October
Neuronal subtype specification and lineages
within the developing zebrafish retina
Dr Jihanne Homman- Research Fellow
Ludiye
10 October
Guidance molecules contribute to
patterning visual cortical areas
Dr David Elliott
Research Fellow
17 October
Building the human cardiac cell lineage
tree: identifying the initial shoots.
Dr Cyril Picard
Research
Assistant
24 October
Two distinct muscle progenitor populations
coexist throughout amniote development
Associate Professor
Ann Chidgey
Deputy Group
Leader
24 October
Limitations and strategies for thymic
epithelial cell regeneration
Dr Gurpreet Kaur
Research Fellow
31 October
Searching for DNA targets in the mouse
embryo
Dr Alex Pinto
Research Fellow
7 November
Immunological basis for cardiac
senescence
Dr Milena Furtado
Senior Research
Fellow
14 November
Insights into cardiac fibroblast identity
Professor Claude
Bernard
Group Leader
14 November
Neural differentiation of multiple sclerosisspecific induced pluripotent stem cells as a
novel approach for disease modelling and
drug discovery
Dr Alex Pinto
Research Fellow
28 November
Immunological basis for cardiac
senescence
Dr Martin Short
PhD Student
28 November
Paracrine signalling by Mesenchymal Stem
Cells and Amnion Epithelial Cells
Professor Christophe
Marcelle
Group Leader
5 December
Unorthodox Notch and Wnt signalling in
early myogenesis
Page
71
research activities
editorial boards
ARMI Rep
Publication
Role
Since
nadia Rosenthal
Developmental Biology
editorial board
2001
BioMednet (mouse models of
diseases reviews)
Guest editor
2001
Developmental Dynamics
editorial Board
2003
Rejuvenation Research
editorial Board
2004
Disease Models and Mechanisms
Founding editor
2007
Stem Cell Research and therapy
editorial Board
2010
Differentiation
editor-in-Chief
2012
Development
editorial advisory board
2006
editorial advisory board
2011
Member, editorial Board
2002
Member, editorial Board
2007
nature
Peer reviewer/guest
2010
Peer reviewer/guest
2010
Peer reviewer/guest
2010
Gene expression Patterns
Peer reviewer/guest
2009
Journal of Molecular Histology
Peer reviewer/guest
2011
Plant Molecular Biology
Peer reviewer/guest
2012
Mechanisms of Development
Peer reviewer/guest
2008
Current Genomics
Peer reviewer/guest
2012
open Journal of Cell Biology
Peer reviewer/guest
2012
Journal of experimental Medicine
Ad hoc reviewer
2005
Stem Cells
Ad hoc reviewer
2006
BMC Developmental Biology
Ad hoc reviewer
2009
Stem Cell Research
Ad hoc reviewer
2009
translational neuroscience
Associate editor
2011
experimental Brain Research
Co-editor
2010
early Human Development
editorial Board
2007
the open Zoology Journal
editorial Board
2007
Peter Currie
Christophe Marcelle
edwina McGlinn
Julian Heng
tiziano Barberi
James Bourne
Page
72
Activities
Advisory Boards and Committees
Name
Organisation
Board/C’ttee name
Role
Since
Nadia Rosenthal
Scientific Advisory Committee,
Genethon, Paris
Scientific Advisory
Committee
Member
2000
Scientific Advisory Board,
Scientific Advisory
Harefield Research Foundation, Committee
London
Member
2001
EMBL representative, European
Life Sciences Forum (ELSF)
EMBL
representative
2001
International Mouse
Mutagenesis Consortium
Member
2002
European Group on Life
Sciences (EGLS)
Member
2002
International Society of
Differentiation
President-elect
2002
Peter Currie
Institute of Advanced Studies,
University of Western Australia
Scientific Advisory
Board
Member
2005
Keystone Symposia
Scientific Advisory
Board
Member
2005
Center for Molecular Medicine,
Vienna
Scientific Advisory
Board
Member
2007
Institute of Molecular Biology
and Biotechnology, Heraklion,
Crete
Scientific Advisory
Board
Member
2008
Max Planck Institute
Scientific Advisory
Board
Member
2012
Development
Editorial advisory
board
Member
2006
45th meeting of the Japanese
Society for Developmental
Biology
Advisory Committee
Member
2012
Global Facioscapulohumeral
Scientific Advisory
Muscular Dystrophy Association Board
Member
2008
Human Frontiers Science
Member
2005
Founding
member
2007
International
fellowship committee
International steering
committee on zebrafish
research
James Bourne
Neurosciences Victoria Ltd
Scientific Advisory
Committee
Member
2008
Christophe
Marcelle
Scientific Advisory
Board
Member
2011
Robin Hobbs
Monash Early-Career
Researcher
Steering Committee
Member
2012
Page
73
conference organising committees
Name
Conference
Role
Peter Currie
10th International Zebrafish Meeting, Madison
Wisconsin, uSA, 2012.
organising Committee
45th meeting of the Japanese Society for
Developmental Biology May 2012, Kobe Convention
Center Japan
Advisory Committee
Fifth Melbourne Cell and Developmental Biology
meeting of the Australia and new Zealand Society for
Cell and Developmental Biology
organiser
ARMI external Seminar Series
Chair
Professor ed Manser (IMB, Singapore), speaker for
the Monash Developmental Biology eminent Speakers
Program
organiser and host
Symposia on neural Development, ComBio 2012,
Adelaide, Australia
organiser
Julian Heng
memberships
Name
Society
Role
Since
nadia Rosenthal
American Society for Biochemistry and Molecular
Biology
Member
1988
American Society for Cell Biology
Member
1992
Society for Developmental Biology
Member
1994
Board of trustees
1996
northeastern
Representative
1997
Australia and new Zealand Society for Cell and
Member
2001
International Society of Differentiation
Member
2002
european Molecular Biology organization (eMBo)
Member
2002
Australian and new Zealand Society of Cell and
Developmental Biologists
Member
2003
ARC/nHMRC Research network in Genes and
environment in Development
Founding member
2004
Society for Muscle Biology
Member
International steering committee on zebrafish
research
Member
2007
Australian and new Zealand Society for Cell and
Member
2012
Peter Currie
edwina McGlinn
Page
74
Activities
Memberships (cont)
Name
Society
Role
Since
Christophe
Marcelle
Editorial
Board Member
2002
Editorial
Board Member
2007
Monash Micro Imaging Scientific
Advisory Board
Member
2010
Robin Hobbs
Society for Reproductive Biology
Member
2012
Graham Lieschke
Haematology Society of Australia & New Zealand
Member
1991
Medical Oncology Group of Australia
Member
1991
Clinical Oncology Society of Australia
Member
1992
American Society of Hematology
Member
1992
Australian Medical Association (AMA)
Member
1997
Australian and New Zealand Society for Cell and
Developmental Biology Inc (ANZSCDBI)
(President 9/2004-9/2006)
Member
1997
Member
2003
National Association of Research Fellows
Member
2009
EuFishBioMed (COST action BM0804)
Member
2010
Julian Heng
Tiziano Barberi
James Bourne
Jan Kaslin
International Society of Experimental Hematology
Member
2010
Research Translation Faculty, The National Health
and Medical Research Council of Australia
Member
2012
International Society for Neurochemistry
Member
2011
The Australian and New Zealand Society for Cell
and Developmental Biology (ANZSCDB)
Member
2008
Australian Neuroscience Society (ANS)
Member
2008
New York Academy of Sciences
Member
International Society for Stem Cell Research
Member
The Science Advisory Board
Member
International Society for Developmental
Neuroscience
Member
2006
Australian Society for Medical Research
Member
2004
Society for Neuroscience, US
Member
2001
Australian Neuroscience Society
Member
2000
Biochemical Society, UK
Member
1995
Royal College of Science, UK
Member
1994
Society for Neuroscience
Member
2001
Federation of European Neuroscience Societies
Member
2011
Brain Research Society of Finland
Member
2011
Australian Neuroscience Society
Member
2011
German Neuroscience Society
Member
2010
Page
75
awards / honours / prizes & travel awards
Name
Awarded By
Award
Value
Yona Goldshmit
ARMI
travel Grant
$1,000
Christina Keightley
ARMI
travel Grant
$1,000
Robin Hobbs
erasmus Mundus, eu
erasmus Mundus
Invited Scholar
€2,500
Monash university
larkins Fellowship
teaching
Name
Program
Since
Julian Heng, lecturer, Monash
university
DeV3990 Action in Developmental biology
research project
2011–2012
Gen3990 Genetics in Action Research Project
MeD4101 Honours Degree in Bachelor of
Medical Science
DeV3032 Stem cells and the foundations of life
DeV3022 Developmental pathways to health and
disease
edwina McGlinn, Guest lecturer,
Monash university
Dev3011 Fundamentals of developmental
processes
Dev2011 early human development from cells
to tissues
2011–2012
Page
76
Activities
Conferences and Seminars
Name
Name of Meeting
Location
Role
Edwina
McGlinn
Combio 2012
Adelaide,
South Australia
Invited speaker
COST Action Meeting – Hox and
Tale Transcription Factors in
Development and Disease
Barcelona, Spain
Invited speaker
Lorne Genome meeting
Lorne, Victoria
Invited speaker
Nicolas
Plachta
Hunter Meeting
Hunter Valley, NSW
Invited speaker
Christophe
Marcelle
Frontiers in Muscle Biology
New York, USA
Invited speaker
Israeli Society for Developmental
Biology
Israel
Keynote speaker
The 12th Hunter Meeting
Hunter Valley, NSW
Invited speaker
Robin Hobbs
The Annual Scientific Meeting of
the Endocrine Society of Australia
and the Society for Reproductive
Biology
Queensland
Invited speaker
Graham
Lieschke
Dr von Haunersches Kinderspital,
19 March, “Acute inflammation
in a myeloperoxidase-deficient
zebrafish mutant”
Munich, Germany
Grand Rounds Seminar
2nd European Zebrafish PI
Meeting (EZPM 2012), 21–13
March, “Leukocyte development
and function in vivo—studies in
zebrafish”.
Karlsruhe, Germany
Invited speaker
ZDM5 “Fishing for answers:
zebrafish models of human
development and disease” (5th
Zebrafish Disease Modelling
Workshop, a Cold Spring Harbor
Asia meeting), 16–20 April,
“Learning about leukocytes in
inflammation and infection using
zebrafish models”.
Suzhou, China
Invited speaker
10th International Conference
on Zebrafish Development and
Genetics, 20–24 June, Hematology
and Immunology Concurrent
Session.
Madison, Wisconsin,
USA
Chairperson
Page
77
Name
Name of Meeting
Location
Julian Heng
BRIMS neuroscience Symposium
2012
Kuala lumpur, Malaysia Invited speaker
the Kunming Institute of Zoology
Kunming, China
Invited speaker
ComBio 2012
Adelaide, South
Australia
Invited plenary speaker
James
Bourne
Role
Melbourne, Victoria
Fifth Melbourne Cell and
Developmental Biology meeting
of the Australia and new Zealand
Society for Cell and Developmental
Biology
Conference convenor
Gordon Research Conference on
neural Development
Rhode Island, uSA
Invited speaker
Department of Surgery, the
university of Melbourne
Melbourne, Victoria
Invited presentation
32nd Annual Meeting of the
Australian neuroscience Society
Gold Coast, Queensland
Speaker
31st Australian neuroscience
Society meeting
Gold Coast, Queensland
Invited speaker
Regenerative Medicine, university
of Western Australia
Perth, Western Australia Invited speaker
Monash Biomedical Imaging
opening Symposium
Monash university,
Melbourne, Victoria
Invited speaker
Queensland Brain Institute
Brisbane, Queensland
Invited speaker
Baker IDI Institute
Melbourne, Victoria
Invited speaker
Monash Medical Centre Clinical
neurology
Melbourne, Victoria
Invited speaker
teAM VIC Regenerative Medicine
Symposium
Monash university,
Melbourne, Victoria
Invited speaker
nation trauma Research
Institute—Plenary Speaker at
national Symposium
Melbourne, Victoria
Invited speaker
Marmoset Research International
(Sfn Satellite)
new orleans, uSA
Invited speaker
Japanese Society for Medical
Research—Speaker at annual
meeting
tokyo, Japan
Invited speaker
Second Indian ocean Rim Muscle
Colloquium, February 6–7
Bangalore, India
Invited speaker
Page
78
Activities
Conferences and Seminars (cont)
Name
Name of Meeting
Location
Role
Peter Currie
“Frontiers in Muscle Biology”
sponsored by the International
Society for Muscle Biology
New York, USA
Invited speaker
5th Annual Zebrafish Disease
Models Meeting Fishing for
Answers: Zebrafish Models of
Human Development and Disease,
16–20 April, Cold Spring Harbor
Asia Conference
Suzhou, China
Invited speaker
Australian and New Zealand
Society of Cell and Developmental
Biology
NSW
Keynote speaker
Centre for Cancer Biology
South Australia
Invited speaker
Southern Health Research Week
Melbourne, Victoria
Keynote speaker
Infrafrontier—European mouse
resources
Germany
Plenary speaker
Keystone Cardiovascular
Development and Regeneration
Symposium
Taos, New Mexico
Plenary speaker
Everett Symposium, Charleston
Charleston, USA
Keynote speaker
3rd Australasian Wound & Tissue
Repair Society Meeting, “Repair
and Regeneration”, 22–24 May
Sydney, NSW
Keynote speaker
9th World Biomaterials congress
Chengdu, China
Plenary speaker
Australia-China Symposium on
Healthy Ageing, 22–24 July
Canberra, ACT
Invited speaker
Joint meeting of the International
Society of Differentiation and
the Netherlands Institute of
Regeneration, 5–8 November
Amsterdam,
The Netherlands
Invited speaker
Creative Innovation 2012
Melbourne, Victoria
Keynote speaker
Nadia
Rosenthal
Page
79
students
higher degree by research (phd) students
PhD Student
Supervisor
Project
Scholarship
Bianca Borchin
tiziano Barberi
Derivation of skeletal muscle
progenitors from human
embryonic stem cells
Australian Rotary Health
Scholarships
leon teo
James Bourne
novel conjugated
biomaterials in the treatment
of neurotrauma and
neurodegeneration
SMARt Scholarship and ARMI
Department Scholarship
ophelia ehrlich
Peter Currie
nanomedicine based
therapies for extracellular
matrix diseases
SMARt Scholarship
Zhenhua li
Peter Currie
Investigating muscle
regeneration in zebrafish
muscular dystrophy mutants
Monash Graduate Scholarship and
Monash International Postgraduate
Research Scholarship
Wouter
Masselink
Peter Currie
Cellular interplay of pectoral
fin myogenic progenitor cells
ARMI Department Scholarship
Phong nguyen
Peter Currie
origins and genetic control
of progenitor and stem cells
from zebrafish
Australian Postgraduate Award
Ivan ng
Julian Heng
Genetic analysis of
neocortical development in
mice
Sultan
Alasmari
Graham
lieschke
Studies of neutrophil
behaviour and function in vivo
Sponsored by the Saudi Arabian
Cultural Mission
Vahid Pazhakh
Graham
lieschke
Regulation of leukocyte
behaviour during
inflammation in vivo
eamon
Coughlan
edwina McGlinn
miR-196 in the development
of the CnS
Australian Postgraduate Award
Daniel Sieiro
Mosti
Christophe
Marcelle
Molecular pathways involved
in vertebrate myoblast fusion
Faculty of Medicine International
Postgraduate Research
Scholarship
Page
80
Activities
Honours Students
Honours Student
Supervisor
Project
Skye Kinder
James Bourne
The role of Ephrins A2 and A5 in the development of
the mammalian visual cortex
Linh Ngo
Julian Heng
The role of the cytoskeleton in the pathogenesis of
microcephaly and mental retardation
Jeremy Ng
Christophe Marcelle
Expression Analysis and Functional Study of
Candidate Genes for Muscle Fusion
Tegan Strait
Nadia Rosenthal (Milena
Furtado)
Understanding cardiac regeneration in mammals
Joelle Perera
Nadia Rosenthal (Mauro
Da Costa)
Developing Mouse Models for Nkx2-5 derived dilated
cardiomyopathy
Ryan Debuque
Nadia Rosenthal (Mauro
Da Costa)
Generation of MES cells as a platform for the study
of transcriptional networks and signalling events
in cardiomyocyte specification, homeostasis and
regeneration.
Undergraduate Research Opportunities Program (UROP) Students
ARMI hosted six Undergraduate Research Opportunities Program (UROP) students in 2012, three of which
went on to pursue Honours (one at ARMI) and all of which were excellent students.
UROP provides high calibre undergraduate students with an opportunity to gain experience in a research
environment. The selection process is highly competitive and prospective students are matched to specific
projects/supervisors. The program is run through the Bio21 Cluster. Bio21 Cluster, a not-for-profit public
company, is the governing body of a collaborative cluster of 22 Melbourne institutions, encompassing
universities, tertiary health services, medical research institutes, CSIRO and other member-based
organisations. The program is a paid employment scheme and is open to any undergraduate student
enrolled in a Victorian tertiary institution.
UROP Student
Group
Supervisor
Project
Andrew Giang
Currie
Patricia Jusuf
Genetic control of generating visual nerve
cells during development
Ibrahim Yousef
Currie
Yona Goldshmit
Pro-regenerative mechanisms involve in
zebrafish spinal cord regeneration.
Caroline Roberts
Heng
Julian Heng
Understanding the genetic mechanisms for
cell migration during brain development
Daniel
Colquhoun
Kaslin
Jan Kaslin
The role of HMG proteins and splicing factors
in developmental neurogenesis and adult
regeneration
Emily Scott
Lieschke
Cristina Keightley
Investigation of ZBTB11 protein-protein
interactions.
Mark Sedrak
Marcelle
David Salgado
Compare data management system and
application creation
Page
81
undergraduate students
Undergraduate Student
Research Group
Program
Anthony Boghdadi
Bourne
Summer Vacation Scholarship /
Research in Action
Dylan Fox
Bourne
Summer Vacation Scholarship
Chloe Hammond
Bourne
Research in Action
Gopika Krishnamurthy
Bourne
Winter Vacation Scholarship /
Research in Action
Stephanie Houston
Heng
Winter Vacation Scholarship /
Research in Action
Sophia Mah
Heng
Winter Vacation Scholarship
Felicity Barnes
Hobbs
Summer Vacation Scholarship
Daniel Colquhoun
Kaslin
Research in Action
Ismath elias
Marcelle
Research in Action
John Jordan
McGlinn
Research in Action
Glenda Caruso
McGlinn
Research in Action
Shuk-Yin tsang
McGlinn
Research in Action
Alice Wookey
Rosenthal
Research in Action
International visiting students
Visiting Student
Institute of Origin
Group
Project title
Denis Azabdaftari
university of Applied
Sciences Berlin,
Germany
lieschke
new transgenic tools for
studying inflammation
in zebrafish
Johannes Wittig
university of Applied
Science HS-lausitz,
Germany
lieschke
transgenic zebrafish for
studying leukocytes
Page
82
Activities
Postdoctoral Research Staff
Postdoctoral
Researcher
Supervisor
Project
Yona Goldshmit
Peter Currie
Mechanisms involved in central nervous
system injuries
Joachim Berger
Peter Currie
Modelling human myopathies in zebrafish
Catherine Boisvert
Peter Currie
Skeletal evolution in early gnathostomes
Patricia Jusuf
Peter Currie
Developmental fate determination of neural NHMRC
subtypes in the zebrafish retina
CJ Martin
fellowship
Ashley Siegel
Peter Currie
Generating a targeted mutation resource in
zebrafish
Ivana Mirkovic
Peter Currie
Role of the scube gene family during
vertebrate muscle development
James Godwin
Nadia Rosenthal
The immunological regulation of
salamander regeneration
Alex Pinto
Nadia Rosenthal
Biology of macrophages in the injured and
uninjured mammalian health
Mauro Da Costa
Nadia Rosenthal
Role of the cardiac transcription factors in
homeostasis and disease
Milena Furtado
Nadia Rosenthal
Understanding the role of cardiac
transcriptional networks in the nonmyocardial component in homeostasis and
regeneration
Ekaterina
Salimova
Nadia Rosenthal
Dissecting roles of pro-regenerative factors
IGF-1 and Relaxin in promoting cardiac
repair and regeneration
Stem Cells
Australia
Lina Wang
Nadia Rosenthal
Differentiation of cardiomyocytes and
skeletal myocytes from embryonic stem
cells
Stem Cells
Australia
Olivier Serralbo
Christophe
Marcelle
Genetic control of the myoblast
differentiation
David Salgado
Christophe
Marcelle
Compare/Myobase multiorganism
database for muscle biology and muscular
disease
Frederico
Calhabeu
Christophe
Marcelle
Characterisation of muscle progenitor
populations during embryogenesis
Claire Hirst
Christophe
Marcelle
The generation and use of reporters to
delineate the molecular pathways involved
in myogenesis
Felix Ellett
Graham Lieschke
Analysis of leukocyte behaviours in
response to P. marneffei infection
Fellowship
Human
Frontiers
ARC Linkage
project
Page
83
Postdoctoral
Researcher
Supervisor
Project
Cristina Keightley
Graham lieschke
Investigating the roles of novel transcription
factor, Zbtb11, in myelopoiesis and liver
development in health and disease
Chieh-Huei Wang
Graham lieschke
Study of leukocyte response to redox
signals during inflammation
Isabella Mengarelli tiziano Barberi
Generation of neural crest cells from
human eS Cells
Joly Kwek
tiziano Barberi
Role of prominin-1 in human embryonic
stem cell differentiation
Jihane Hommanludiye
James Bourne
Molecular patterning of the primate visual
cortex.
Gurpreet Kaur
nicolas Plachta
transcription factor diffusion dynamics in
the developing mouse embryo
Juan Carlos
Fierro-Gonzalez
nicholas Plachta
Combining single-cell imaging and
quantitative methods to study the
molecular mechanisms regulating
the adaptive capacity of cells in living
mammalian embryos.
Melanie White
nicholas Plachta
Imaging the early events patterning
mammalian embryos
Alysha Heimberg
edwina McGlinn
the evolution of Hox-embedded microRnA
genes and the animal body plan
Jesus Casanova
edwina McGlinn
microRnA control of vertebral number and
identity
Fellowship
Wenner-Gren
Foundations
(WGS), and
Swedish
Society for
Medical
Research
(SSMF)
Postdoctoral
Fellowships
Page
84
Activities
BioEYES Outreach Program
BioEYES Australia is an innovative, hands-on
approach to teaching primary and secondary
students about developmental biology, stem cells
and regeneration. Over the course of a week,
students watch the transparent eggs of zebrafish
change from a single-celled zygote to a larval fish.
Through school incursions facilitated by University
lecturers and researchers, students study the
lifespan and development of zebrafish anatomy,
habitat and genetics.
BioEYES Mission
• Excite children about the thrill of scientific
discovery
• Encourage students to develop their critical
thinking skills, perform
• Collaborate on experiments with classmates
studying anatomy, circulation, respiration,
genetics and habitat
• Enhance research excellence by building
linkages with research users and providers
against the backdrop of Monash stem cell
science and biomedical research, enhancing
international collaborative endeavours
• Capture the inherent enthusiasm and
excitement that students have for science;
open their eyes to possible and fulfilling futures
in research
This year BioEyes has continued to reach students
from schools across the greater Melbourne
metropolitan area. Additional schools are signing
up as we go to press.
In 2011, the Department of Innovation, Industry,
Science and Research (DIISR) provided a small
grant to BioEYES which was critical in seeking
further funding, in particular, from Schools
Connect, an independent organisation focused
on facilitating partnerships between education,
business and philanthropy. BioEYES Australia was
selected as one of five recipients for funding from
Schools Connect.
With additional funding, we have been able to
employ Anmei Vuong as our primary outreach
educator. Anmei has been an invaluable participant
in the program and works closely with both
students and teachers on delivery of BioEYES.
Further information about BioEYES Australia
including booking an event for primary school
students is available from Sharon Flecknoe at
[email protected].
Page
85
Publications
1. Asharani, P.V., K. Keupp, o. Semler, W. Wang, Y. li, H. thiele, G. Yigit, e. Pohl, J. Becker, P. Frommolt, C.
Sonntag, J. Altmuller, K. Zimmermann, D.S. Greenspan, n.A. Akarsu, C. netzer, e. Schonau, R. Wirth,
M. Hammerschmidt, P. nurnberg, B. Wollnik, and t.J. Carney, Attenuated BMP1 function compromises
osteogenesis, leading to bone fragility in humans and zebrafish. Am J Hum Genet, 2012. 90(4): 661-674
Category: Genetics & Heredity Impact Factor: 10.603 Ranking: 8/157
2. Benard, e.l., A.M. van der Sar, F. Ellett, G.J. Lieschke, H.P. Spaink, and A.H. Meijer, VIDeo: Infection of
zebrafish embryos with intracellular bacterial pathogens. J Vis exp, 2012. 61(e3781): 1-8
3. Berger, J. and P.D. Currie, Zebrafish models flex their muscles to shed light on muscular dystrophies.
Dis Model Mech, 2012. 5(6): 726-732 Category: Cell Biology Impact Factor: 4.937 Ranking: 54/181
4. Berger, J., T. Sztal, and P.D. Currie, Quantification of birefringence readily measures the level of muscle
damage in zebrafish. Biochem Biophys Res Commun, 2012. 423(4): 785-788 Category: Biochemistry &
Molecular Biology Impact Factor: 2.484 Ranking: 173/289
5. Bogoyevitch, M.A, Y.Y. Yeap, Z. Qu, K.R. ngoei, Y.Y. Yip, t.t. Zhao, J.I. Heng, and D.C. ng, WD40-repeat
protein 62is a JnK-phosphorylated spindle pole protein required for spindle maintenance and timely
mitotic progression. J Cell Sci, 2012. nov 1;125(Pt 21): 5096-109
6. Breuss, M., J.I. Heng, K. Poirier, G. tian, X.H. Jaglin, Z. Qu, A. Braun, t. Gstrein, l. ngo, M. Haas, n.
Bahi-Buisson, M.l. Moutard, S. Passemard, A. Verloes, P. Gressens, Y. Xie, K.J. Robson, D.S. Rani, K.
thangaraj, t. Clausen, J. Chelly, n.J. Cowan, and D.A. Keays, Mutations in the Ð-tubulin gene tuBB5
cause microcephaly with structural brain abnormalities. Cell Rep, 2012. Dec 27;2(6):1554-62
7. Bryson-Richardson, R.J., S. Berger, and P.D. Currie, Atlas of Zebrafish Development. 1st ed, ed. R.
Bryson-Richardson. Vol. 1. 2012, uK: Academic Press. 238 [ARMI,SOBS]
8. Cai, H., F.S. Santiago, l. Prado-lourenco, B. Wang, M. Patrikakis, M.P. Davenport, G.J. Maghzal,
R. Stocker, C.R. Parish, B.H. Chong, G.J. Lieschke, t.W. Wong, C.n. Chesterman, D.J. Francis, F.J.
Moloney, R.S. Barnetson, G.M. Halliday, and l.M. Khachigian, DnAzyme targeting c-jun Suppresses
Skin Cancer Growth. Sci transl Med, 2012. 4(139): 139ra82.1-12 Category: Cell Biology Impact Factor:
7.804 ranking: 26/180
9. Chandras, C., M. Zouberakis, e. Salimova, D. Smedley, n. Rosenthal, and V. Aidinis, CreZoo--the
european virtual repository of Cre and other targeted conditional driver strains. Database (oxford),
2012. 2012(bas029.): 1-5 Category: Mathemathics & Computational Biology Impact Factor: 2.071
Ranking: 15/47
10. da Silva, M.G., e. Mattos, J. Camacho-Pereira, t. Domitrovic, A. Galina, M.W. [da] Costa, and e.
Kurtenbach, Cardiac systolic dysfunction in doxorubicin-challenged rats is associated with upregulation
of MuRF2 and MuRF3 ligases. exp Clin Card, 2012. 17(3): 101-109 Category: Cardiac & Cardiovascular
Systems Impact Factor: 0.576 Ranking: 109/117
11. Dworkin, S., C. Darido, S.R. Georgy, t. Wilanowski, S. Srivastava, F. Ellett, L. Pase, Y. Han, A. Meng,
J.K. Heath, G.J. lieschke, and S.M. Jane, Midbrain-hindbrain boundary patterning and morphogenesis
are regulated by diverse grainy head-like 2-dependent pathways. Development, 2012. 139(3): 525-536
Category: Developmental Biology Impact Factor: 6.596 Ranking: 5/40
12. Ellett, F. and G.J. Lieschke, Computational Quantification of fluorescent leukocyte numbers in
Zebrafish embryos, in Methods in enzymology – Imaging and Spectroscopic Analysis of living
CellsImaging live Cells in Health and Disease, P. Conn, editor. 2012, Academic Press: uSA. 425-435
Book Chapter
Page
86
Activities
13.Frisca, F., R.A. Sabbadini, Y. Goldshmit, and A. Pebay, Biological effects of lysophosphatidic acid in the
nervous system. Int Rev Cell Mol Biol, 2012. 296: 273-322 Category: Biochemistry & Molecular Biology
Impact Factor: 4.481 Ranking: 70/289
14.Frugier, T., A. Conquest, C. McLean, P. Currie, D. Moses, and Y. Goldshmit, Expression and activation
of EphA4 in the human brain after traumatic injury. J Neuropathol Exp Neurol, 2012. 71(3): 242-250
Category: Clinical Neurology Impact Factor: 4.258 Ranking: 26/191
15.Ganz, J., J. Kaslin, D. Freudenreich, A. Machate, M. Geffarth, and M. Brand, Subdivisions of the adult
zebrafish subpallium by molecular marker analysis. J Comp Neurol, 2012. 520(3):633-55
16.Garcia-Cao, I., M.S. Song, R.M. Hobbs, G. Laurent, C. Giorgi, V.C. de Boer, D. Anastasiou, K. Ito, A.T.
Sasaki, L. Rameh, A. Carracedo, M.G. Vander Heiden, L.C. Cantley, P. Pinton, M.C. Haigis, and P.P.
Pandolfi, Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell, 2012. 149(1):
49-62 Category: Biochemistry & Molecular Biology Impact Factor: 32.403 Ranking: 2/290
17.Garcia-Moreno, F., N.A. Vasistha, N. Trevia, J.A. Bourne, and Z. Molnar, Compartmentalization of
cerebral cortical germinal zones in a lissencephalic primate and gyrencephalic rodent. Cereb Cortex,
2012. 22(2): 482-492 Category: Neurosciences Impact Factor: 6.544 Ranking: 22/243
18.Goldshmit, Y., R. Matteo, T. Sztal, F. Ellett, F. Frisca, K. Moreno, D. Crombie, G.J. Lieschke, P.D. Currie,
R.A. Sabbadini, and A. Pebay, Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury
Outcomes. Am J Pathol, 2012. 181(3): 978-992 Category: Pathology Impact Factor: 4.890 Ranking: 6/78
19.Goldshmit, Y., T.E. Sztal, P.R. Jusuf, T.E. Hall, M. Nguyen-Chi, and P.D. Currie, Fgf-dependent glial cell
bridges facilitate spinal cord regeneration in zebrafish. J Neurosci, 2012. 32(22): 7477-7492 Category:
Neurosciences Impact Factor: 7.115 Ranking: 19/243
20.Hansson, J., M. Reza Rafiee, S. Reiland, J.M. Polo, J. Gehring, S. Okawa, W. Huber, K. Hochedlinger,
and J. Krijgsveld, Highly coordinated proteome dynamics during reprogramming of somatic cells to
pluripotency, Cell Reports, 2012. 2(6):1579-1592
21.Hede, M.S., E. Salimova, A. Piszczek, E. Perlas, N. Winn, T. Nastasi, and N. Rosenthal, E-peptides
control bioavailability of IGF-1. PLoS One, 2012. 7(12): e51152.1-11 Category: Biology Impact Factor:
4.092 Ranking: 12/85
22.Heimberg, A. and E. McGlinn, Building a robust A-P Axis. Curr Genomics, 2012. 13(4): 278-288
Category: Genetics & Heredity Impact Factor: 2.408 Ranking: 89/158
23.Hobbs, R.M., S. Fagoonee, A. Papa, K. Webster, F. Altruda, R. Nishinakamura, L. Chai, and P.P. Pandolfi,
Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell, 2012.
10(3): 284-298 Category: Cell Biology Impact Factor: 25.421 Ranking: 4/181 [ARMI,MISCL]
24.Hochmann, S., J. Kaslin, S. Hans, A. Weber, A. Machate, M. Geffarth, R.H. Funk, and M. Brand, Fgf
signaling is required for photoreceptor maintenance in the adult zebrafish retina. PLoS One, 2012. 7(1):
e30365.1-12 Category: Biology Impact Factor: 4.092 Ranking: 12/85
25.Homman-Ludiye, J., T.D. Merson, and J.A. Bourne, The early postnatal nonhuman primate neocortex
contains self-renewing multipotent neural progenitor cells. PLoS One, 2012. 7(3): e34383 Category:
Biology Impact Factor: 4.092 Ranking: 12/85
26.Hu, J.K., E. McGlinn, B.D. Harfe, G. Kardon, and C.J. Tabin, Autonomous and nonautonomous roles of
Hedgehog signaling in regulating limb muscle formation. Genes Dev, 2012. 26(18): 2088-2102 Category:
Cell Biology Impact Factor: 11.659 Ranking: 3/40
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87
27. Johnson, J.l., T.E. Hall, J.M. Dyson, C. Sonntag, K. Ayers, S. Berger, P. Gautier, C. Mitchell, G.e.
Hollway, and P.D. Currie, Scube activity is necessary for Hedgehog signal transduction in vivo. Dev
Biol, 2012. 368(2): 193-202 Category: Developmental Biology Impact Factor: 4.069 Ranking: 7/40
[ARMI,BCH]
28. Jusuf, P.R., S. Albadri, A. Paolini, P.D. Currie, F. Argenton, S. Higashijima, W.A. Harris, and l. Poggi,
Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2. J neurosci, 2012. 32(40):
13929-13944 Category: neurosciences Impact Factor: 7.115 Ranking: 19/244
29. Kaslin, J. and M. Brand, Cerebellar development and neurogenesis in zebrafish. In Handbook of the
Cerebellum and Cerebellar Disorders, M. Manto, D. Gruol, J. Schmahmann, n. Koibuchi, and F. Rossi,
editors, 2012, Springer: new York, Berlin, Heidelberg
30. Kizil, C.#, J. Kaslin#, V. Kroehne, and M. Brand, Adult neurogenesis and brain regeneration in
zebrafish. Dev neurobiol, 2012. Mar;72(3):429-61 (# these authors contributed equally to the work)
31. Kizil, C., n. Kyritsis, S. Dudczig, V. Kroehne, D. Freudenreich, J. Kaslin, and M. Brand, Regenerative
neurogenesis from neural Progenitor Cells Requires Injury-Induced expression of Gata3. Dev Cell,
2012. 23: 1-8 Category: Cell Biology Impact Factor: 14.030 Ranking: 9/181
32. Krallinger, M., F. leitner, M. Vazquez, D. Salgado, C. Marcelle, M. tyers, A. Valencia, and A. Chatraryamontri, How to link ontologies and protein-protein interactions to literature: text-mining
approaches and the BioCreative experience. Database (oxford), 2012. 2012(Article bas017): 1-12
Category: Mathematical & Computational Biology Impact Factor: 2.071 Ranking: 15/47
33. Kyritsis, n., C. Kizil, S. Zocher, V. Kroehne, J. Kaslin, D. Freudenreich, A. Iltzsche, and M. Brand,
RePoRt: Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain.
Science, 2012. 338(6112): 1353-1356 Category: Multidisciplinary Sciences Impact Factor: 31.201
Ranking: 2/56
34. lam, n.t., P.D. Currie, G.J. Lieschke, N.A. Rosenthal, and D.M. Kaye, nerve growth factor stimulates
cardiac regeneration via cardiomyocyte proliferation in experimental heart failure. PloS one, 2012.
7(12): e53210.1-9 Category: Biology Impact Factor: 4.092 Ranking: 12/85
35. Lui, L.L., A.E. Dobiecki, J.A. Bourne, and M.G. Rosa, Breaking camouflage: responses of neurons in
the middle temporal area to stimuli defined by coherent motion. eur J neurosci, 2012. 36(1): 2063-2076
Category: neurosciences Impact Factor: 3.631 Ranking: 80/243 [ARMI,PHY]
36. Macheda, M.l., W.W. Sun, K. Kugathasan, B.M. Hogan, n.I. Bower, M.M. Halford, Y.F. Zhang, B.e.
Jacques, G.J. Lieschke, A. Dabdoub, and S.A. Stacker, the Wnt Receptor Ryk Plays a Role in
Mammalian Planar Cell Polarity Signaling. J Biol Chem, 2012. 287(35): 29312-29323 Category:
Biochemistry & Molecular Biology Impact Factor: 4.773 Ranking: 66/289
37. Mansfield, J.H. and E. McGlinn, evolution, expression, and developmental function of Hox-embedded
miRnAs, in Curr top Dev Biol, PM Wasserman and o. Pourquie, editors. 2012, Academic Press: uSA.
31-57 Category: Developmental Biology Impact Factor: 6.000 Ranking: 6/40
38. Martin, K.R., A. Corlett, D. Dubach, t. Mustafa, H.A. Coleman, H.C. Parkington, t.D. Merson, J.A.
Bourne, S. Porta, M.l. Arbones, D.I. Finkelstein, and M.A. Pritchard, over-expression of RCAn1 causes
Down syndrome-like hippocampal deficits that alter learning and memory. Hum Mol Genet, 2012. 21(3):
3025-3041 Category: Genetics & Heredity Impact Factor: 7.636 Ranking: 13/157 [BCH,PHY,ARMI]
39. Nguyen-Chi, M.E., R. Bryson-Richardson, C. Sonntag, T.E. Hall, A. Gibson, T. Sztal, W. Chua, t.F.
Schilling, and P.D. Currie, Morphogenesis and Cell Fate Determination within the Adaxial Cell
equivalence Group of the Zebrafish Myotome. PloS Genet, 2012. 8(10): e1003014.1-16 Category:
Genetics & Heredity Impact Factor: 8.694 Ranking: 11/158
Page
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Activities
40.Nicholls, C., A.R. Pinto, H. Li, L. Li, L. Wang, R. Simpson, and J.P. Liu, Glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA
component. Proc Natl Acad Sci U S A, 2012. 109(33): 13308-13313 Category: Multidisciplinary Sciences
41.Pase, L., J.E. Layton, C. Wittmann, F. Ellett, C.J. Nowell, C.C. Reyes-Aldasoro, S. Varma, K.L. Rogers,
C.J. Hall, M.C. Keightley, P.S. Crosier, C. Grabher, J.K. Heath, S.A. Renshaw, and G.J. Lieschke,
Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding
in zebrafish. Curr Biol, 2012. 22(19): 1818-1824 Category: Biochemistry & Molecular Biology Impact
Factor: 9.647 Ranking: 18/290
42.Pase, L., C.J. Nowell, and G.J. Lieschke, In Vivo Real-Time Visualization of Leukocytes and Intracellular
Hydrogen Peroxide Levels During a Zebrafish Acute Inflammation Assay, in Methods in Enzymology –
Imaging and Spectroscopic Analysis of Living CellsImaging Live Cells in Health and Disease, P. Conn,
Editor. 2012, Academic Press: USA. 135-156 Book Chapter
43.Pinto, A.R., R. Paolicelli, E. Salimova, J. Gospocic, E. Slonimsky, D. Bilbao-Cortes, J.W. Godwin, and
N.A. Rosenthal, An abundant tissue macrophage population in the adult murine heart with a distinct
alternatively-activated macrophage profile. PLoS One, 2012. 7(5): e36814.1-11 Category: Biology Impact
Factor: 4.092 Ranking: 12/84
44.Polo, J.M., E. Anderssen, R.M. Walsh, B.A. Schwarz, C.M. Nefzger, S.M. Lim, M. Borkent, E. Apostolou,
S. Alaei, J. Cloutier, O. Bar-Nur, S. Cheloufi, M. Stadtfeld, M.E. Figueroa, D. Robinton, S. Natesan,
A. Melnick, J. Zhu, S. Ramaswamy, and K. Hochedlinger, A Molecular Roadmap of Reprogramming
Somatic Cells into iPS Cells. Cell, 2012. 151(7): 1617-1632 Category: Biochemistry & Molecular Biology
Impact Factor: 32.403 Ranking: 2/290 [MISCL,ARMI]
45.Rios, A.C. and C. Marcelle, A tale of stolen kiss in muscle. Med Sci (Paris), 2012. 28(3): 264-266
Category: Medicine, Research & Experimental Impact Factor: 0.516 Ranking: 94/111
46.Rios, A.C., C. Marcelle, and O. Serralbo, Gene loss-of-function and live imaging in chick embryos, in
Methods Mol Biol, K. Turksen, Editor. 2012, Humana Press: USA. 105-117
47.Rosenthal, N. and C. Stewart, EDITORIAL: In search of a wide-angle perspective. Differentiation, 2012.
83(3): iii-iv (3-4) Category: Cell Biology Impact Factor: 2.807 Ranking: 106/180
48.Ruparelia, A.A., M. Zhao, P.D. Currie, and R.J. Bryson-Richardson, Characterization and Investigation
of zebrafish models of Filamin related myofibrillar myopathy. Hum Mol Genet, 2012. 21(18): 4073-4083
Category: Biochemistry & Molecular Biology Impact Factor: 7.636 Ranking: 31/289
49.Salgado, D., M. Krallinger, M. Depaule, E. Drula, A. Tendulkar, F. Leitner, A. Valencia, and C. Marcelle,
MyMiner: a web application for computer-assisted biocuration and text annotation. Bioinformatics,
2012. 28(17): 2285-2287 Category: Mathematical & Computational Biology Impact Factor: 5.468
Ranking: 1/47
50.Salgado, D., C. Marcelle, P.D. Currie, and R.J. Bryson-Richardson, The Zebrafish Anatomy Portal:
A novel integrated resource to facilitate zebrafish research. Dev Biol, 2012. 372(1): 1-4 Category:
Developmental Biology Impact Factor: 4.069 Ranking: 7/40
51.Santini, M.P. and N. Rosenthal, Myocardial Regenerative Properties of Macrophage Populations and
Stem Cells. J Cardiovasc Transl Res, 2012. 5(5): 700-712 Category: Cardiac & Cardiovascular Systems
52.Sztal, T., H. Chung, S. Berger, P.D. Currie, P. Batterham, and P.J. Daborn, A cytochrome p450
conserved in insects is involved in cuticle formation. PLoS One, 2012. 7(5): e36544.1-9 Category: Biology
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53. Sztal, T.E., C. Sonntag, T.E. Hall, and P.D. Currie, epistatic dissection of laminin-receptor interactions
in dystrophic zebrafish muscle. Hum Mol Genet, 2012. 21(21): 4718-4731 Category: Biochemistry &
Molecular Biology Impact Factor: 7.636 Ranking: 31/289
54. Teo, L., J. Homman-Ludiye, J. Rodger, and J.A. Bourne, Discrete ephrin-B1 expression by specific
layers of the primate retinogeniculostriate system continues throughout postnatal and adult life. J
Comp neurol, 2012. 520(13): 2941-2956 Category: neurosciences Impact Factor: 3.808 Ranking:
69/243
55. Teo, L., J.V. Rosenfeld, and J.A. Bourne, ReVIeW: Models of CnS injury in the nonhuman primate: a
new era for treatment strategies. trans neuroscience, 2012. 3(2): 181-195
56. touvron, M., B. escoubet, M. Mericskay, A. Angelini, l. lamotte, M.P. Santini, N. Rosenthal, D.
Daegelen, D. tuil, and J.F. Decaux, locally expressed IGF1 propeptide improves mouse heart function
in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CtGF induction.
Dis Model Mech, 2012. 5(4): 481-491 Category: Cell Biology Impact Factor: 4.937 Ranking: 54/180
57. Warner, C.E., W.C. Kwan, and J.A. Bourne, the early Maturation of Visual Cortical Area Mt is
Dependent on Input from the Retinorecipient Medial Portion of the Inferior Pulvinar. J neurosci, 2012.
32(48): 17073-17085 Category: neurosciences Impact Factor: 7.115 Ranking: 19/244
58. Wittmann, C., P. Chockley, S.K. Singh, L. Pase, G.J. Lieschke, and C. Grabher, ReVIeW: Hydrogen
peroxide in inflammation: messenger, guide, and assassin. Adv Hematol, 2012. 2012: 541471.1-6
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How to donate to ARMI
ARMI researches the basic mechanisms behind the
process of regeneration, seeking to find effective
treatments for a range of diseases. Your donation
can help fund our research projects.
Donors can choose to support the Australian
Regenerative Medicine Institute in a variety of ways:
1. For an online gifts please go to
https://community.monash.edu.au/givetoarmi
2. If it is more convenient to donate by cheque or
money order, donations can be mailed to:
Monash University Advancement
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4. Make a gift by phone
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2012 Annual Report

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