79th EAS CONGRESS
Transcription
79th EAS CONGRESS
FINAL PROGRAMME CONGRESS ORGANISERS The 79th EAS Annual Congress 1-3, rue du Chantepoulet; P.O. Box 1726 CH-1211 Geneva 1, Switzerland Tel: +41 22 908 0488; Fax: +41 22 906 9140 E-Mail: [email protected] Website: www.kenes.com/eas eas2011_final.indd 3 6/10/11 9:49 AM June 26-29, 2011 CONTENTS Welcoming Words V Committees VI Faculty List VII About EAS IX Acknowledgements XI About Gothenburg XIV The Anitschkow Award XVI XVII Young Investigator Awards General Information XIX Instruction for Oral Presenters XXII Instruction for Poster Presenters XXIII Overview of Moderated Poster Sessions XXIV Company Sponsored Educational Symposia & EBAC Accredited Educational Programme and Special Sessions XXVII XXIX Opening Ceremony XXX Social Programme Hall Name Eulogy of Distinguished Scientists XXXI List of Official Congress Hotels XXXIII Caring for the Environment XXXIV Venue Floor Plans XXXV Exhibition Floor Plan & Exhibitor List XXXVI Exhibitor & Sponsor Profiles XXXVII Scientific Programme 1 Sunday, 26 June, 2011 Monday, 27 June, 2011 7 Tuesday, 28 June, 2011 19 Wednesday, 29 June, 2011 31 Poster Presentations and Moderated Poster Sessions 37 149 Index IV eas2011_final.indd 4 6/10/11 9:49 AM FINAL PROGRAMME WELCOMING WORDS Dear Colleagues, Welcome to the 79th EAS Congress in Gothenburg, Sweden! The Congress is hosted by the Scandinavian Society for Atherosclerosis Research. All the Scandinavian countries are represented in the organising committee, and have worked together with the EAS Scientific Programme Committee to prepare a programme that includes the latest developments in the field of atherosclerosis, and timely reviews presented by outstanding plenary speakers. Although there have been considerable advances in our understanding of this disease in recent years, atherosclerosis remains the major cause of death in the industrialised world. The EAS has been, and continues to be, a major contributor to developments in the field. For EAS 2011 we have created a programme of interest both to junior and established basic scientists and to clinical researchers and practitioners. Our goal is to promote interaction between these different groups, to ensure that frontline basic research is translated into disease prevention and treatment. There is also a special focus on new treatment guidelines, and a major effort to present accessible, interesting and interactive poster sessions. You will find that the Gothenburg Convention Centre, located in the city centre within walking distance of the major hotels, offers convenient facilities, allowing you to select your favourite topics among the parallel sessions and visit the exhibitions. Gothenburg is Sweden’s second largest city and is at its most beautiful in June. It is located at the mouth of the Göta river on the west coast of southern Sweden and has many attractions, including the picturesque archipelago, the largest amusement park in Scandinavia, and numerous parklands and nature areas. On behalf of the organising committee, we welcome you to the Gothenburg 79th EAS Congress, 2011 - a stimulating meeting offering enjoyable and rewarding interactions between basic and clinical researchers in the field of atherosclerosis. Olov Wiklund Congress Chairperson Jan Borén Congress Co-Chairperson Petri Kovanen Chairman of the Scientific Programme Committee M. John Chapman EAS President V eas2011_final.indd 5 6/10/11 9:49 AM June 26-29, 2011 COMMITTEES CONGRESS CHAIRPERSON LOCAL ORGANISING COMMITTEE Olov Wiklund, Sweden Olov Wiklund, Sweden, Chair Bo Angelin, Stockholm, Sweden Jan Borén, Gothenburg, Sweden Ruth Frikke-Schmidt, Denmark Bente Halvorsen, Oslo, Norway Anders Hamsten, Stockholm, Sweden Eva Hurt-Camejo, Gothenburg, Sweden Petri Kovanen, Helsinki, Finland Lars-Bo Nielsen, Copenhagen, Denmark Terje R. Pedersen, Oslo, Norway Karl Swedberg, Gothenburg, Sweden Marja-Riitta Taskinen, Helsinki, Finland CONGRESS CO-CHAIRPERSON Jan Borén, Sweden EAS EXECUTIVE COMMITTEE M. John Chapman, President Lale Tokgözoglu, Vice President Jan Borén, Treasurer Petri Kovanen, Secretary, Scientific Committee Chair Alberico L. Catapano Olivier Descamps Luís Masana Rudolf Zechner SCIENTIFIC COMMITTEE POSTER AWARD COMMITTEE Petri Kovanen, Finland, Chair Ulrike Beisiegel, Germany John Betteridge, UK Jan Borén, Sweden Alberico Catapano, Italy M. John Chapman, France Fernando Civeira, Spain Göran Hansson, Sweden Andrew Newby, UK Gerard Pasterkamp, The Netherlands Arnold von Eckardstein, Switzerland Olov Wiklund, Sweden Rudolf Zechner, Austria Ruth Frikke-Schmidt, Denmark, Chair Martin Adiels, Sweden Marianne Benn, Denmark Francisco Blanco-Vaca, Spain Phillipe Costet, France Ewa Ehrenborg, Sweden Jörg Heeren, Germany Dimitris Kardassis, Greece Florian Kronenberg, Austria Monique Mulder, The Netherlands Guiseppe Norata, Italy APPRECIATION AND THANKS We would like to thank the reviewers of the submitted abstracts and The Young Investigator Award Jury for their valuable help and assistance. VI eas2011_final.indd 6 6/10/11 9:49 AM FINAL PROGRAMME FACULTY LIST M. Adiels, Sweden F. Andreotti, Italy B. Angelin, Sweden M. Bäck, Sweden F. Bäckhed, Sweden P. Barter, Australia U. Beisiegel, Germany M. Benn, Denmark C. Betsholtz, Sweden J. Betteridge, UK E.A. Biessen, The Netherlands F. Blanco-Vaca, Spain S. Blankenberg, Germany G. Bondjers, Sweden J. Borén, Sweden I. Bosaeus, Sweden B. Brewer, USA W.V. Brown, USA G. Camejo, Sweden A. Catapano, Italy M.J. Chapman, France Y. Chatzizisis, Greece R. Choudhury, UK F. Civeira, Spain P. Costet, France M. Daemen, The Netherlands G.M. Dallinga-Thie, The Netherlands N. Danchin, France G. De Backer, Belgium U. de Faire, Sweden P. de Groot, The Netherlands J. Defesche, The Netherlands E. Dennis, USA O. Descamps, Belgium M. Diamant, The Netherlands E. Ehrenborg, Sweden M. Eriksson, Sweden B. Fagerberg, Sweden E. Falk, Denmark Z.A. Fayad, USA R. Frikke-Schmidt, Denmark C. Glass, USA J.F.C. Glatz, The Netherlands L. Grip, Sweden H. Gylling, Finland J. Haeggström, Sweden B. Halvorsen, Norway A. Hamsten, Sweden G.K. Hansson, Sweden L. M. Havekes, The Netherlands J. Heeren, Germany J. W. Heinecke, USA M.L. Hellenius, Sweden H. Hobbs, USA M. Hofker, The Netherlands S. Humphries, UK E. Hurt-Camejo, Sweden E. Ikonen, Finland M. Jauhiainen, Finland C. Jern, Sweden L. Johansson, Sweden D. Kardassis, Greece M. Kaste, Finland S. Kathiresan, USA A. Kontush, France P. Kovanen, Finland F. Kronenberg, Austria E. Larose, Canada I. Larsson, Sweden N. Leitinger, USA M. Levin, Sweden P. Libby, USA T. LÜscher, Switzerland R. Marchioli, Italy L. Masana, Spain L. Mattsson Hultén, Sweden J. Mercer, UK M. Mulder, The Netherlands A. Newby, UK L.B. Nielsen, Denmark J. Nilsson, Sweden G. Norata, Italy B. Nordestgaard, Denmark V. Olkkonen, Finland S.O. Olofsson, Sweden A. Olsson, Sweden K. Öörni, Finland G. Pasterkamp, The Netherlands P. Pedersen, Norway J. Perk, Sweden S. Potteaux, France G. Randolph, USA Z. Reiner, Croatia G. Riccardi, Italy S. Romeo, Sweden E. Ros, Spain A. Rosengren, Sweden J. Rudd, UK B. Staels, France P. Stenvinkel, Sweden A. Steptoe, UK E. Stroes, The Netherlands K. Swedberg, Sweden I. Tabas, USA M.R. Taskinen, Finland T. Tholstrup, Denmark S.L. Tokgözoglu, Turkey S. Tsimikas, USA A. Tybjærg-Hansen, Denmark T. van Berkel, Norway A. von Eckardstein, Switzerland L. Wallentin, Sweden C. Weber, Germany P. Wester, Sweden O. Wiklund, Sweden J. Wikstrand, Sweden K.J. Williams, USA S. Young, USA R. Zechner, Austria VII eas2011_final.indd 7 6/10/11 9:49 AM June 26-29, 2011 EUROPEAN ATHEROSCLEROSIS SOCIETY Join the EAS and become a member of the society that connects European scientists and clinicians interested in atherosclerosis research. ...advancing and exchanging knowledge concerning the causes, natural history, treatment and prevention of atherosclerotic disease EAS membership has many benefits, including member-rate registration fee at EAS Congresses and educational activities, eligibility for EAS grants and awards, and on-line access to our journal, Atherosclerosis. You can find out more about the Society’s activities, and apply for membership, via our website: www.eas-society.org For more information contact Carmel Hayes or Josefine Harbrecht at the EAS Office (address below): European Atherosclerosis Society Kronhusgatan 11 SE-411 05, Gothenburg SWEDEN Tel: +46(0)31 724 27 95 Fax: +46(0)31 724 27 01 Email: [email protected] Web: www.eas-society.org VIII eas2011_final.indd 8 6/10/11 9:49 AM FINAL PROGRAMME ABOUT EAS EUROPEAN ATHEROSCLEROSIS SOCIETY The European Atherosclerosis Society was founded in 1964. Its goal is to promote understanding of atherosclerosis: advancing knowledge of its causes, natural history, treatment and prevention. An elected Executive Committee plans and runs a programme of activities – which include a large annual congress, smaller scientific workshops, advanced courses, and supported fellowships – all opportunities for professional interaction and education. Membership Membership is open to physicians and scientists who carry out research in both basic and clinical science, in Europe and in neighbouring countries. Corresponding members, active in atherosclerosis research, are accepted from around the world Supporting Young Scientists A major goal of the society is to support young scientists - their participation in EAS activities will bring new ideas for the future. EAS activities provide them with opportunities to meet and discuss with more-senior colleagues, and to present their own work. In selected cases, EAS offers financial support, in the form of awards and grants for travel. Advanced Courses To fulfill its aims to promote education and training in the prevention and care of atherosclerosis EAS has launched a series of Advanced Courses in Atherosclerosis. These courses will each highlight a different aspect of basic science and research or clinical prevention, diagnosis and treatment in the field of atherosclerotic vascular disease and its complications. The courses are run by recognised experts and distinguished specialists in the relevant research or clinical area, and are held in established centres of excellence throughout Europe. Consensus Position Paper Initiative The EAS Consensus Panel, comprised of 18 internationally renowned experts in atherosclerosis and cardiovascular disease, was convened in 2009 to consider the evidence for non-LDL lipids as risk factors for cardiovascular disease. The resulting articles, “Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management” and “Lipoprotein(a) as a cardiovascular risk factor: current status” are available as open access publications by European Heart Journal. IX eas2011_final.indd 9 6/10/11 9:49 AM June 26-29, 2011 ABOUT EAS (cont.) Collaborations The EAS collaborates with other European and international scientific societies on joint educational symposia, guidelines task forces and other projects of mutual interest within the field of cardiovascular research. Guidelines EAS has pioneered guidelines on the prevention of cardiovascular disease with panEuropean campaigns in 1987 and 1988. EAS joined forces with the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) to issue the first set of joint European Guidelines on Prevention of Coronary Artery Disease in 1994. The current revision of these Guidelines is available via the EAS website, www.eas-society.org. Specific Guidelines are also being developed between EAS and ESC on Management of Dyslipidemias. Publication is scheduled for June 2011, during EAS 2011, where they will be presented during a plenary session, and covered in detail at a post-Congress satellite meeting. These Guidelines will also be available at www.eas-society.org. Journal The society’s Journal ‘Atherosclerosis’ is a well-respected, monthly peer-reviewed journal, available online at : www.atherosclerosis-journal.com. Support EAS activities are supported by the membership fees of individual members. EAS actively includes companies in the society as corporate partners, who work with EAS to support research and educational programmes. For further information about EAS, visit our website: www.eas-society.org or contact the administrative executive, Dr Carmel Hayes, at the Society’s Administrative Office at the address below: Kronhusgatan 11, SE-411 05, Gothenburg, Sweden Tel: +46(0)31 724 27 95 Fax: +46(0)31 724 27 01 Email: [email protected] X eas2011_final.indd 10 6/10/11 9:49 AM FINAL PROGRAMME ACKNOWLEDGEMENTS CORPORATE PARTNERS The EAS Executive Committee would like to express its sincere appreciation to the following Corporate Partners for their continued support of the missions and activities of the European Atherosclerosis Society. The 79th EAS Congress would like to thank Volvo for providing a VIP Limousine car service. XI eas2011_final.indd 11 6/10/11 9:49 AM June 26-29, 2011 ACKNOWLEDGEMENTS The EAS Committee would like to express their sincere appreciation to the following organisations for their support in the 79th EAS Annual Congress. PLATINUM SPONSOR GOLD SPONSORS SILVER SPONSORS SUPPORTERS XII eas2011_final.indd 12 6/10/11 9:49 AM FINAL PROGRAMME EXHIBITORS XIII eas2011_final.indd 13 6/10/11 9:49 AM June 26-29, 2011 ABOUT GOTHENBURG Gothenburg is located on the beautiful west coast of Sweden, easily accessible from around the world. Being the second largest city in Sweden, Gothenburg blends a distinct feeling of charm with the pulse of modern urban life. Meeting venues, hotels, restaurants, shops and entertainment are all located within easy walking distance. The city’s spectacular surroundings, closeness to forests and the sea, with its stunning archipelago, guarantee a whole new meeting experience, far from that of traditional big-city meetings. Easily accessible from around the world, Gothenburg is an excellent venue for major events and meetings. Two international airports are located here and the city is a major Swedish railway network hub. Gothenburg has a reputation for being clean, safe and green with a relaxed and friendly atmosphere. The Gothenburg archipelago is an extraordinary experience. Thousands of islands lie scattered along the west coast all the way up to Oslo, Norway. You can find many untouched spots, and explore charming fishing villages. With a public transport ticket you can take the tram to the ferries, in 20 minutes, for a trip to the southern archipelago. Gothenburg is a city full of contrasts, where trendy glass and stainless steel bars stand beside beautiful 19th century buildings with splendid entrances, old wooden County Governor houses and beautiful parks. A number of city tours are available, for instance a dramatised city sightseeing walk with historically dressed guides. XIV eas2011_final.indd 14 6/10/11 9:49 AM FINAL PROGRAMME There are many attractions to choose from - Liseberg Amusement Park, the Göteborg Opera House, Gothenburg Symphony Orchestra - Sweden’s national orchestra, the Art Museum’s fascinating collections, Universeum Science Centre, the Museum of World Culture and a wide repertoire of entertaining shows, sports, cultural events, fairs and exhibitions. Gothenburg is a must for the gourmet as it is home to the highest number of first-class restaurants per capita in the whole of Scandinavia - some with stars in the Guide Michelin. The main culinary attraction in Gothenburg is the local seafood; prawns, lobster and a wideselection of fish, ranked amongst the finest in the world. The city also offers a considerable number of great restaurants offering cuisine from all over the world, at reasonable prices. In the heart of the city everything from fashionable boutiques and department stores, to picturesque markets selling crafts, souvenirs and antiquities are located within easy walking distance. Gothenburg offers an exiting mixture of modern warehouses and specialist shops, pedestrian areas, galleries and arcades - all guaranteed to make shopping a memorable experience. Gothenburg has a long and successful tradition of trade and industry, and some of Scandinavia’s best-known corporations such as Volvo, SKF, ESAB and Hasselblad have their origins and head offices here. A significant proportion of Sweden’s exports and imports pass through Gothenburg’s port, the largest in Scandinavia. XV eas2011_final.indd 15 6/10/11 9:49 AM June 26-29, 2011 THE ANITSCHKOW AWARD THE ANITSCHKOW AWARD IN ATHEROSCLEROSIS RESEARCH, 2011 Professor Philip Barter DIRECTOR OF THE HEART RESEARCH INSTITUTE IN SYDNEY, AUSTRALIA The EAS is delighted to announce that the recipient of the Society’s prestigious Anitschkow Award 2011 is Professor Philip Barter, Director of The Heart Research Institute in Sydney, Australia. Presentation of the Award and the Anitschkow Medal will take place at the Opening Ceremony of the 79th EAS Congress, Gothenburg, Sweden, June 26-29, 2011, where Professor Barter will present the Anitschkow Lecture. Professor Philip Barter Professor Barter is a dedicated and outstanding scientist who has made, and who continues to make, unique contributions to the advancement of atherosclerosis research by active clinical and basic research, teaching and national and international relations. He has a longstanding research interest in the diagnosis, pathogenesis and therapy of risk factors of atherosclerosis. By combining basic and clinical research he is an excellent example of a from-bench-to-bedside researcher. Since the 1970s he and his coworkers have repeatedly made pivotal and pioneering contributions to better understand the metabolism and function of plasma lipoproteins, notably HDL. His more than 250 original publications and more than 50 review papers have been cited about 15,000 times, and placing him in the top 1% of most frequently cited scientists in the field of clinical sciences. XVI eas2011_final.indd 16 6/10/11 9:49 AM FINAL PROGRAMME YOUNG INVESTIGATOR AWARDS Dr. Yiannis S. Chatzizisis, MD, PhD from the Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA Publication: Dr. Yiannis S. Chatzizisis Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation 2011;123:621-30 Award statement: This study explored the local hemodynamic and molecular mechanisms that determine the localized formation of thin-capped fibroatheromas in the coronary arteries of diabetic, hyperlipidemic swine. The study demonstrated that: (1) arterial areas with low preceding endothelial shear stress have reduced endothelial cell coverage and enhanced lipid accumulation and inflammation, (2) they exhibit increased expression of messenger RNAs encoding matrix metalloproteinase-2, -9, and -12 and cathepsins K and S relative to their endogenous inhibitors and increased elastolytic activity and (3) the expression of these enzymes correlates positively with the severity of internal elastic lamina fragmentation. These results provide new insight into the hemodynamic and molecular mechanisms of regional formation of plaques with thin fibrous cap and indicate that the in-vivo understanding of local endothelial shear stress may allow identification of a high-risk plaque in its early stages of development. Early identification of a high-risk plaque may provide a rationale for selective local coronary interventions, supplemented by an intensive systemic pharmacological approach, to avert future acute coronary events. XVII eas2011_final.indd 17 6/10/11 9:49 AM June 26-29, 2011 YOUNG INVESTIGATOR AWARDS (cont.) Dr. John Mercer at the Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK Publication: Dr. John Mercer Mercer, J, Cheng, KK, Figg, N, Gorenne, I, Mahmoudi, M, Griffin, J, Vidal-Puig, A, Logan, A, Murphy, MP, Bennett, MR. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome (2010). Circ Res ;107;1021-1031 Award Statement: Many studies have found that DNA damage is increased in atherosclerosis, but its role is unclear. Dr Mercer’s studies show that DNA damage directly promotes atherosclerosis and multiple features of the metabolic syndrome. He also identifies that damage to mitochondrial DNA and dysfunction may underlie both pathologies, by damage to the vessel wall cells and systemic metabolic disturbance. The study opens the way for agents that reduce mitochondrial reactive oxygen species and protect against mitochondrial damage and dysfunction as potential therapeutic agents in both diseases. XVIII eas2011_final.indd 18 6/10/11 9:49 AM FINAL PROGRAMME GENERAL INFORMATION VENUE The Swedish Exhibition Centre / Svenska Mässan Mässans Gata/Korsvägen, Sweden Postal address: SE-412 94. Gothenburg Tel: +46 31-708 80 00 Fax: +46 31-16 03 30 E-mail: [email protected] Website: www.svenskamassan.se DIALING CODES & IMPORTANT TELEPHONE NUMBERS The International dialing code for Sweden is +46 The Gothenburg area code is 31 Emergency numbers: Police - 112; Fire Brigade - 112; Ambulance - 112 REGISTRATION / INFORMATION / SECRETARIAT DESK The Registration Desk will be situated at Entrance 5, Congress Centre Sweden, for the duration of the congress and will be open as follows: OPENING HOURS Sunday, June 26, 2011 Monday, June 27, 2011 Tuesday, June 28, 2011 Wednesday, June 29, 2011 09:00 – 18:00 08:00 – 18:30 08:00 – 18:30 08:00 – 19:00 BADGES On registering you will receive your congress kit and name badge. You are kindly requested to wear your badge during all congress sessions and events. EXHIBITION HOURS Sunday, June 26, 2011 Monday, June 27, 2011 Tuesday, June 28, 2011 Wednesday, June 29, 2011 15:00 – 20:30 10:00 – 18:00 10:00 – 18:00 08:30 – 12:30 FOOD & BEVERAGE We wish to thank for sponsoring the coffee breaks on Monday 27th June and Tuesday 28th June, and for sponsoring the Welcome Reception. XIX eas2011_final.indd 19 6/10/11 9:49 AM June 26-29, 2011 CYBER CENTRE There will be a Cyber Centre equipped with workstations where attendees may check e-mails. ABSTRACT MEMORY STICK The congress abstracts will be published on a USB Memory Stick. You are welcome to visit the EAS booth and collect it. If you would like to print any of the abstracts while at the congress, please look for the printing stations in the exhibition area. CERTIFICATE OF ATTENDANCE The Certificate of Attendance may be printed from the self-service stations in the registration area from Tuesday, 28th June, 2011 CME ACCREDITATION An application for the CME accreditation has been made to the European Board for Accreditation in Cardiology (EBAC). The EBAC works in cooperation with the European Accreditation Council for Continuing Medical Education (EACCME) which is an institution of the European Union of Medical Specialists (UEMS) www.uems. net. Delegates are kindly requested to scan their name badge when they enter & leave the congress area. EBAC Desk will be situated in the registration area (Entrance 5). For more information please contact the information desk. BANKING & EXCHANGE The official currency is the Swedish Krona. Foreign currency may be changed at banks during normal banking hours, at hotels, at airports and in exchange offices. All major credit cards are acceptable in most hotels, restaurants and shops. MAIL / MESSAGES / MEDICAL ASSISTANCE / LOST & FOUND Please apply to the Information Desk. LANGUAGE English is the official language of the Congress. All presentations will be made in English. CLOTHING Clothing is informal for all occasions. MOBILE PHONES Please note that mobile phones must be switched off during all sessions. XX eas2011_final.indd 20 6/10/11 9:49 AM FINAL PROGRAMME SESSIONS Please make sure to be in session halls on time as all sessions will begin as per schedule. SMOKING POLICY Smoking is prohibited at all times in the meeting halls, exhibit halls and restrooms. Your compliance is appreciated. LIABILITY AND INSURANCE The Congress Secretariat and Organisers cannot accept liability for personal accidents or loss of or damage to private property of participants and accompanying persons. Participants are advised to take out their own personal travel and health insurance for their trip. SAFETY AND SECURITY Please do not leave bags or suitcases unattended at any time, whether inside or outside session halls. Hotels strongly recommend that you use their safety deposit boxes for your valuables. PRESS Journalists must register at the Registration Desk. Upon registration the journalists will receive a press kit including the detailed press briefing schedule. Press releases will be available to the journalists in association to the press briefings in the Press Briefing Room. PRESS ROOM HOURS Sunday, June 26, 2011 Monday, June 27, 2011 Tuesday, June 28, 2011 Wednesday, June 29, 2011 12:00 – 20:00 08:30 – 18:30 08:30 – 18:30 08:30 – 12:30 CONGRESS ORGANISERS The 79th EAS Congress 1-3, rue du Chantepoulet; P.O. Box 1726 CH-1211 Geneva 1, Switzerland Tel: +41 22 908 0488 Fax: +41 22 906 9140 E-Mail: [email protected] XXI eas2011_final.indd 21 6/10/11 9:49 AM June 26-29, 2011 INSTRUCTIONS FOR ORAL PRESENTERS SPEAKERS’ READY ROOM A Speakers’ Ready Room will be available every day throughout the Congress for speakers. If using a PowerPoint (or any other computer) presentation, please note you need to bring it on a CD, a DVD or on a “disk on key” memory stick (using the USB port in the computer) and load it on one of the congress’ computers in the Speakers’ Ready Room, at least 1 hour before the start of the session. You may supply your own laptop computer as a back-up. If combining video films with PowerPoint, please make sure to check it in the session hall where your lecture is taking place during a coffee or lunch break prior to your session, at least 30 minutes before the start of the session - even after checking it in the Speakers’ Ready Room. Please note that the Congress’ computers in the session halls are being supplied with Windows and Office 2007. Important Note for Macintosh Users In order to use MAC presentations on a PC compatible computer please note that you need to prepare it according to the instructions below, before bringing it to the Speakers’ Ready Room. • • • Use a common font, such as Arial, Times New Roman, Verdana, etc. (special fonts might be changed to a default font on a PowerPoint based PC). Insert pictures as JPG files (and not TIF, PNG or PICT - these images will not be visible on a PowerPoint based PC). Use a common movie format, such as AVI, MPG and WMV (MOV files from QuickTime will not be visible on a PowerPoint based PC). You may use your own Macintosh laptop computer as a back-up. In such a case please confirm that it has a VGA socket for external signal and come to check it first in the Speakers’ Ready Room as soon as you arrive and later on in the session hall where your lecture is taking place during the coffee or lunch break prior to your session, at least 30 minutes before the start of the session. Please note that VHS Video projection, 35 mm slide projection and Overhead projection (projection of transparencies) will not be available. XXII eas2011_final.indd 22 6/10/11 9:49 AM FINAL PROGRAMME INSTRUCTIONS FOR POSTER PRESENTERS Posters will be on display for the entire congress. Please check the Scientific Programme to see the exact poster board number, date, and time of the poster discussion groups.Posters may be mounted from Sunday, June 26th from 15:30. Presenters are requested to stand next to their posters during the exclusive poster sessions on Monday June 27th from 12:30 - 15:00 and Tuesday, June 28th from 12:30-15:00. The organisers are not responsible for any posters that have not been removed by the end of sessions on Wednesday, June 29th. MODERATED POSTER PRESENTATIONS EAS is proud to introduce moderated poster sessions, providing the unique opportunity for convivial scientific discussions and exchange. For further details please refer to the Overview of Moderated Poster Sessions on the following page. ACKNOWLEDGEMENT OF POSTER MODERATORS EAS is honoured and indebted to the distinguished scientists and clinicians who have accepted to participate in the Moderated Poster Sessions at the EAS Congress. MEET THE SPEAKER SESSIONS Take the opportunity to meet the plenary speakers. At the Meet the Speaker Table in the poster area the plenary speakers will be available for your questions: Monday June 27, 2011 Tuesday June 28, 2011 12:40-14:50 12:40-14:50 Detailed time schedule will be announced during the plenary sessions. XXIII eas2011_final.indd 23 6/10/11 9:49 AM June 26-29, 2011 OVERVIEW OF MODERATED POSTER SESSIONS Kindly note that abstracts marked with a have been selected for discussion during the Moderated Poster Sessions. Moderated Poster Sessions for the track “Lipids, Lipoproteins and Lipid Metabolism” Moderated Poster Session Workshop 1 Metabolism of Atherogenic Lipoproteins and their Role in Atherosclerosis Metabolism of Atherogenic Lipoproteins and their Role in Atherosclerosis Cellular Lipid Metabolism, from Uptake to Storage Cellular Lipid Metabolism, from Uptake to Storage 9 2 3 10 11 12 Day Time Posters Moderator Scientific Page No. Monday 13.50-14.50 1.01-1.07 Louis M. Havekes 37-38 Tuesday 12.40-13.40 1.73-1.79 Erik Biessen 47-48 Monday 13.50-14.50 1.49-1.56 Steven Humphries 43-44 Monday 13.50-14.50 1.97-1.103 Geesje M. Dallinga-Thie 50-51 Mechanisms for the Protective Tuesday 12.40-13.40 Role of HDL Mechanisms for the Protective Tuesday 12.40-13.40 Role of HDL Reactive Lipid Compounds and Tuesday 12.40-13.40 Modified Lipoproteins in Disease Processes 1.121-1.128 Theo van Berkel 53-54 1.146-1.152 Anatol Kontush 57-58 1.169-1.176 Eva Hurt-Camejo 60-61 XXIV eas2011_final.indd 24 6/10/11 9:49 AM FINAL PROGRAMME Moderated Poster Sessions for the track “From the Vulnerable Plaque to the Vulnerable Patient – Challenges for Translational Medicine” Moderated Poster Session Workshop Day 4 Mechanisms for the Progression and Regression of Atherosclerosis Mechanisms for the Progression and Regression of Atherosclerosis Mechanisms for the Progression and Regression of Atherosclerosis Consequences of Inflammation and Immune Response in Atherosclerosis Consequences of Inflammation and Immune Response in Atherosclerosis •Hypoxia and Angiogenesis in the Plaque Monday 13.50-14.50 2.01-2.07 Gerard Pasterkamp 69-70 Monday 13.50-14.50 2.25-2.31 Bente Halvorsen 72-73 Monday 13.50-14.50 2.49-2.55 Kevin J. Williams 75-76 Tuesday 12.40-13.40 2.73-2.80 Jan Nilsson 78-79 Tuesday 12.40-13.40 2.145-2.152 Matti Jauhiainen 87-88 Tuesday 12.40-13.40 2.157-2.158 German Camejo 89 5 6 13 14 15 Time •Nuclear Receptors at the Crossroad of Lipid Metabolism and Inflammation •Thrombogenic Risk Factors for Atherothrombosis and Acute Coronary Events Posters Moderator Scientific Page No. 2.160-2.161 89 3.197-3.199 116 XXV eas2011_final.indd 25 6/10/11 9:49 AM June 26-29, 2011 Moderated Poster Sessions for the track “Genetics, Risk Factors and Epidemiology- from Population to Patients” Moderated Poster Session 16 17 18 19 Workshop Day Time Posters Moderator Scientific Page No. Biomarkers - From Bench to Bedside Biomarkers - From Bench to Bedside Psychosocial, Socioeconomic and Life Style Factors as Determinants of Cardiovascular Disease Novel Genes Related to Atherogenesis and Lipid Metabolism – Do they Increase our Understanding of the Disease? Tuesday 12.40-13.40 3.25-3.32 John Betteridge 94-95 Tuesday 13.50-14.50 3.74-3.79 Luis Masana 99-100 Tuesday 13.50-14.50 3.121-3.128 Anders Olsson 105-106 Tuesday 13.50-14.50 3.146-3.152 Florian Kronenberg 108-109 Moderated Poster Sessions for the track “Diagnosis, Prevention and Treatment of Cardiovascular Disease” Moderated Poster Session Workshop Day Time 7 Healthy Diets and Functional Food A Road to Prevention Healthy Diets and Functional Food A Road to Prevention New Challenges and Targets of Cardiovascular Prevention and Treatment Imaging Techniques in Atherosclerosis, Diagnostics and Progress Monitoring Imaging Techniques in Atherosclerosis, Diagnostics and Progress Monitoring Monday 13.50-14.50 4.01-4.08 Lars Bo Nielsen 117-118 Monday 13.50-14.50 4.73-4.80 Helena Gylling 125-127 Tuesday 13.50-14.50 4.110-4.117 Terje R. Pedersen 130-132 Tuesday 13.50-14.50 4.168-4.175 Lale Tokgözuglu 138-139 Tuesday 13.50-14.50 4.176-4.182 Felicita Andreotti 139-140 8 20 21 22 Posters Moderator Scientific Page No. XXVI eas2011_final.indd 26 6/10/11 9:49 AM FINAL PROGRAMME COMPANY SPONSORED EDUCATIONAL SYMPOSIA, EBAC ACCREDITED EDUCATIONAL PROGRAMME AND SPECIAL SESSIONS SUNDAY, JUNE 26, 2011 COMPANY SPONSORED EDUCATIONAL SYMPOSIUM 14:00 – 15:30, E. Nikkilä Hall Atorvastatin, An Enduring Legacy COMPANY SPONSORED EDUCATIONAL SYMPOSIUM 16:00 – 17:30, E. Nikkilä Hall In Focus: Modifying CETP to Reduce Cardiovascular Risk? EBAC ACCREDITED EDUCATIONAL PROGRAMME 16:00 – 17:30, T. Svedberg Hall Effective Implementation of Evidence-Based Cardiovascular Disease Prevention MONDAY, JUNE 27, 2011 EBAC ACCREDITED EDUCATIONAL PROGRAMME 12:45 – 14:15, E. Nikkilä Hall Nutritional Behaviour and Reduction of Cardiovascular Risk: from Basic Science to Clinical Practice COMPANY SPONSORED EDUCATIONAL SYMPOSIUM 17:00 – 18:30, E. Nikkilä Hall New Advances in Cardiovascular Risk Reduction in High-Risk Patients XXVII eas2011_final.indd 27 6/10/11 9:49 AM June 26-29, 2011 COMPANY SPONSORED EDUCATIONAL SYMPOSIUM 17:00 – 18:30, T. Svedberg Hall Severe Familial Hypercholesterolemia, A Genetic Disease that Needs Aggressive Treatment TUESDAY, JUNE 28, 2011 SPECIAL LECTURE 13:50 – 14:30, C. Müller Hall The Role of MTP in Lipoprotein Assembly and in The Development of Novel Therapeutic Approaches SPECIAL LECTURE 15:00 – 15:40, C. Müller Hall C. Müller Hall CETP Inhibition: The Next Frontier In Cardiovascular Therapy EBAC ACCREDITED EDUCATIONAL PROGRAMME 17:00 – 18:30, E. Nikkilä Hall Novel Strategies for Raising HDL-C: Pitavastatin in Clinical Practice EDUCATIONAL SYMPOSIUM 17:00 – 18:30, T. Svedberg Hall The InterChol FH Symposium In appreciation of Roger Williams and MEDPED SPECIAL LECTURE 17:00 – 17:40, C. Müller Hall Cardiovascular Risk in Diabetes: New Therapeutic Approaches XXVIII eas2011_final.indd 28 6/10/11 9:49 AM FINAL PROGRAMME OPENING CEREMONY SUNDAY, JUNE 26, 2011, 18:00 N.N. Anitschkow Hall WELCOME Olov Wiklund Chairperson of the Congress M. John Chapman President of EAS WELCOMING WORDS Elisabet Rothenberg First Deputy Lord Mayor of The City of Gothenburg Conny Brännberg First Deputy President of the Regional Council of Västra Götaland WELCOME Ruth Frikke-Schmidt Scandinavian Society for Atherosclerosis Research MUSICAL PERFORMANCE GREETINGS W. Virgil Brown President of the International Society of Atherosclerosis M. John Chapman Introduction of the Anitschkow Prize Winner Philip Barter The Anitschkow Lecture MUSICAL PERFORMANCE Reception sponsored by Region Västra Götaland and the City of Gothenburg XXIX eas2011_final.indd 29 6/10/11 9:49 AM June 26-29, 2011 SOCIAL EVENTS PROGRAMME MONDAY, JUNE 27, 2011 FACULTY DINNER 20:00 The EAS Faculty are invited to a reception which will be held in the River Café restaurant. (By invitation only) TUESDAY, JUNE 28, 2011 CONGRESS PARTY 19:30 Light dinner will be served at the Gothenburg Opera with live entertainment and dancing. The Poster Awards will be presented to the 20 finalists of the Poster Competition. Ticket Price: €50 and €25 for students. Limited tickets are still available XXX eas2011_final.indd 30 6/10/11 9:49 AM FINAL PROGRAMME HALL NAME EULOGY OF DISTINGUISHED SCIENTISTS Nikolai N. Anitschkow (1885-1964) Professor of the Department of Pathological Physiology of the Military Medical Academy St. Petersburg, Russia In 1913, experimental pathologist Dr. Nikolai N. Anitschkow showed that simply feeding rabbits purified cholesterol dissolved in sunflower oil induced vascular lesions closely resembling those of human atherosclerosis, both grossly and microscopically. Controls fed only the sunflower oil showed no lesions. It is fair to say that this paper marked the beginning of the modern era of atherosclerosis research. Dr. Anitschkow was not only a keen-eyed structural pathologist and a careful experimentalist; he thought in terms of function and time-related pathogenesis. However, the landmark studies by Dr. Anitschkow were largely rejected at the time. An important reason for this was that the findings were inconsistent with the prevailing view of atherosclerosis. It was generally accepted to be an inevitable accompaniment of aging (the “senescence hypothesis”). If the full significance of his findings had been appreciated at the time, we might have saved more than 30 years in the long struggle to settle the cholesterol controversy. In honor of Dr. Nikolai N. Anitschkow, the “Anitschkow Prize in Atherosclerosis Research” by the EAS recognizes outstanding research in the field of atherosclerosis and linked metabolic disturbances. Carl Müller (1886-1983) Carl Müller presented his landmark paper, Angina Pectoris in hereditary Xanthomatosis before the Nordic Congress for Internal Medicine in 1937 and published in the Archives of Internal Medicine in 1939. He was the first to pull together the evidence linking familial hypercholesterolemia to coronary artery disease. XXXI eas2011_final.indd 31 6/10/11 9:49 AM June 26-29, 2011 Esko Nikkilä (1926-1986) Professor of Medicine and Head of Third Department of Medicine, University of Helsinki, Finland Esko Nikkilä was Professor of Medicine at the University of Helsinki from 1962 until his untimely death in 1986 in an automobile accident at the age of 60. Esko Nikkilä was an active, innovative member of the Finnish scientific community, a member of the Finnish Academy of Science and Letters, one of Finland’s leading scientists, and an internationally recognised expert on lipid metabolism and diabetes. He was one of the founding fathers of EAS and a regular participant in EAS meetings. He was a mentor and role model for numerous investigators who now populate major academic positions in Finland including the chairs of this EAS meeting. In 1953, Nikkilä presented his studies on the lipid-protein relationship in normal and pathological sera and the effect of heparin on serum lipoproteins”. He was a true pioneer discovering the role of lipoprotein lipase and reporting that “the amount of cholesterol found in 1 lipoprotein is considerably decreased in the majority of atherosclerotic sera”. These observations, from the start of his exceptional career, stand out as signs of his originality and excellence. HDL became the major focus of his interest and over the years he carried out studies that step-by-step established the detailed mechanisms of HDL metabolism in health and in disease. Esko’s career paralleled the major evolution of arteriosclerosis over more than 30 years. He described the fenotype of FCHL patients 1973 in the Lancet simultaneously with papers by Goldstein JL et al. and Rose HG et al. These basic discoveries made him one of the leading scientists in the field. He was a true pioneer in studies of lipoprotein metabolism in diabetes and atherosclerosis and became a figure of tremendous stature and great internationally respected eminence in lipidology, atherosclerosis and diabetes. He had an admirable facility for tackling his research questions at both the bench and the bedside. He was a valued friend and at meetings, he could always be counted on for warm, sharp humour and incisive perceptions. Theodor Svedberg (1884-1971) Theodor H. E. Svedberg was a Swedish chemist and Nobel laureate, active at Uppsala University. His work with colloids supported the theories of Brownian motion put forward by Einstein and the Polish geophysicist Marian Smoluchowski. During this work, he developed the technique of analytical ultracentrifugation, and demonstrated its utility in distinguishing pure proteins one from another. XXXII eas2011_final.indd 32 6/10/11 9:49 AM FINAL PROGRAMME LIST OF OFFICIAL CONGRESS HOTELS Best Western Hotel Eggers Drottningtorget, 404 25 Gothenburg +46-31 333 44 40 Lorensberg Hotel Berzeliigatan 15, 412 53 Gothenburg +46 31 81 06 00 Elite Park Avenue Kungsportsavenyn 36-38, 400 15 Gothenburg +46 31 727 10 00 Poseidon Hotel Storgatan 33, 411 38 Gothenburg +46 31 10 05 50 First G Hotel Nils Ericsonsplatsen 4, 411 03 Gothenburg +46 11 63 7242 Quality Panorama Hotel Eklandagatan 51-53, 400 22 Gothenburg +46 31 767 70 00 First Hotel Avalon Kungstorget 9, 411 17 Gothenburg + 46 31 751 02 01 Radisson Blu Scandinavia Södra Hamngatan 59-65, 401 24 Gothenburg +46 31 758 50 00 Flora Hotel Grönsakstorget 2, 411 17 Gothenburg +46 31 13 86 16 Royal Hotel Drottninggatan 67, 411 07 Gothenburg +46 31 700 11 70 Gothia Towers (Headquarters Mässans Gata 24, 402 26 Gothenburg +46 31 750 88 00 Scandic Opalen Hotel Engelbrektsgatan 73, 412 52 Gothenburg +46 31 751 53 00 Grand Hotel Opera Nils Ericsonsgatan 23, 404 26 Gothenburg +46 31 80 50 80 Scandic Rubinen Hotel Kungsportsavenyn 24, 411 36 Gothenburg +46 31 751 54 00 Liseberg Heden Hotel Sten Sturegatan 1, 411 39 Gothenburg +46 31 750 69 00 Vasa Hotel Hotel Viktoriagatan 6, 411 25 Gothenburg +46 31 17 36 30 XXXIII eas2011_final.indd 33 6/10/11 9:49 AM June 26-29, 2011 CARING FOR THE ENVIRONMENT EAS and Kenes International are committed to integrating responsible business practices into all of our operations not just by words but deeds. Responsibility to our clients, staff, environment and social issues are paramount to all of our decisions, policies and practices. It is our belief that by employing a Green Culture in the workplace we can duplicate this culture, and the responsibilities it entails, through our core business clients and onsite during our Meetings. As part of this ongoing learning process we wish to share with you the eco friendly conduct of EAS 2011. Green print - The print materials of this congress have been printed on paper made of 50 - 100% paper waste or paper that is FEFC approved. The FEFC is an organisation that certifies paper manufacturers which keep to sustainable forest management criteria. Reducing print - This year the book of abstracts will be published on a USB Stick as well as an online supplement of Atherosclerosis. If you wish to print any of the abstracts while at the Congress, please look for the printing stations in the exhibition area where you can print your choice of abstracts. In addition we have added blank pages at the end of the Final Programme, which you may use for your notes. Recycling - As part of our efforts we try to produce less waste. We will also recycle plastic, glass, cans and paper. Before leaving the congress, please don’t forget to place your badges in the recycle bin for badges. Organising green meetings all over the world is a real challenge, as green is not only the onsite conduct but the suppliers we are using, the source of the raw materials, the methods of production, management of waste, shipping vs. using local products and fair management of labour throughout the supply chain. EAS and Kenes International are committed to the process. XXXIV eas2011_final.indd 34 6/10/11 9:49 AM FINAL PROGRAMME VENUE FLOOR PLANS EAS 2011 G1 1 H2 H2 N.N. Anitschkow Hall G2 G2 22 220 20 285 285 5 Plenary G3 3 220 0 G G4 260 37 370 70 G H1 H1 24 245 45 F1 1 2 0 250 Passage to Focus shopping centre & parking F F2 260 2 60 F F3 220 22 20 First Floor F4 330 33 30 F F5 330 33 30 Post Congress Satellites J1 F6 6 R2 2 0 220 72 R9 R10 Bryggan R26 R21 R22 + R23 E. Nikkilä Hall R11 Press Centre R12 Expo Hall R7 R3 R25 + R24 R4 R5 + R6 Hotel Gothia Towers Meeting Rooms T. Svedberg Hall F Press Center Speakers’ Ready Room V Executive Lounge 320 500 C. Müller Hall Eat & Go Ground Floor 320 C Indoor passage to Plenary Indoor passage from Hotel Gothia Towers Ho te lR ec ep tio n Livingroom Entrance Eden Restaurant Hotel Lobby Hotel Gothia Towers Elevator to Heaven 23 Registration Exhibition & Posters XXXV eas2011_final.indd 35 6/10/11 9:49 AM June 26-29, 2011 EXHIBITION FLOOR PLAN EXHIBITOR LIST COMPANY BOOTH # AstraZeneca 33 Athera Biotechnologies AB 25 B. Braun Avitum AG 14 Cayman Chemical Company 12 Denka Seiken Co.,Ltd. 24 Elsevier 6A European Atherosclerosis Society 35 Fresenius Medical Care Deutschland GmbH 29 Genzyme Corporation 6 International Atherosclerosis Society 15 Kaneka Pharma Europe N.V. (KPE) 26 Kowa Pharmaceutical Europe Co Ltd. 34 Mercodia AB 21 MSD 32 Raisio Group, Benecol Division 8 Randox Laboratories 22 Roche 1 Wisepress Medical Bookshop 7 XXXVI eas2011_final.indd 36 6/10/11 9:49 AM FINAL PROGRAMME EXHIBITOR AND SPONSOR PROFILES AstraZeneca 2 Kingdom Street London W2 6BD UK www.astrazeneca.com AstraZeneca is a global, innovation-driven biopharmaceutical company focused on the discovery, development and commercialisation of medicines that bring benefit for patients and add value for society in important areas of healthcare, including neuroscience, cancer and heart disease. Athera Biotechnologies AB Fogdevreten 2 171 77 Stockholm Sweden www.athera.se Athera Biotechnologies AB was founded in 2002 to exploit breakthrough innovations in cardiovascular disease made at Karolinska Institute. The mission of Athera is to address the large unmet need for anti-inflammatory therapeutics in the prevention and treatment of atherosclerosis, cardiovascular disease (CVD) and premature death. Athera currently runs two pre-clinical biopharmaceutical programs aiming for future treatment of acute cardiovascular disease. In addition, Athera has developed a biomarker and companion diagnostic CVDefine® kit. The biomarker, anti-PC, is linked to increased risk for cardiovascular disease and could in the future be used for identification of patients that benefit from Athera’s novel therapeutics. XXXVII eas2011_final.indd 37 6/10/11 9:49 AM June 26-29, 2011 B. Braun Avitum AG Schwarzenberger Weg 73-79 34212 Melsungen Germany www.bbraun.com B. Braun Avitum concentrates on treatment systems for hemodialysis, acute dialysis and therapeutic apheresis. It provides new prospects for quality of life for patients with chronic renal or metabolic diseases. The expertise of B. Braun Avitum is comprehensive, embracing high-quality machine systems, consumables and a network of dialysis centres. Cayman Chemical Company 1180 East Ellsworth Road Ann Arbor, MI 48108 USA www.caymanchem.com High-quality biochemical research products are available from Cayman Chemical Company including an extensive line of assay kits for measuring lipid mediators, oxidative stress biomarkers, cyclic nucleotides, steroids, and nitric oxide metabolites. Products key to atherosclerosis research include various agonists, antagonists, proteins, and antibodies related to cholesterol trafficking, platelet aggregation, and inflammatory mediators. Danone 15, rue du Helder 75009 Paris Cedex France www.danone.com Danone is one of the largest healthy food companies worldwide with 4 expertise areas in dairy products, bottled waters, baby and medical nutrition. Its mission is to bring health through food to as many people as possible at all the ages of the life, in more than 120 countries. Danone and its 80,000 employees are entirely focused on this mission and R&D budget is dedicated to projects associated with nutrition and health. Its major research centres, Palaiseau (France) and Wageningen (Netherlands) have established more than 200 external scientific partnerships, to develop products with relevant, scientifically proven health XXXVIII eas2011_final.indd 38 6/10/11 9:49 AM FINAL PROGRAMME Denka Seiken Co.,Ltd. 3-4-2 Nihonbashi-kayabacho, Chuo-ku Tokyo, 103-0025 Japan www.denka-seiken.co.jp Denka Seiken manufactures clinical chemistry and latex-enhanced serum protein reagents for automated chemistry analyzers such as CRP, Lp(a), Myoglobin, HDL-C, LDL-C, etc. Denka Seiken currently features a reagent that can quantitatively determines small, dense low-density lipoproteins (small, dense LDL). The s LDL-EX “SEIKEN” is a homogeneous assay consisting of two ready-to-use liquid reagents to be used on automated chemistry analyzers. The test is fully automated and has within-run precisions of 1 – 2 %. Test result is available in 10 minutes. The assay methodology correlates well with the traditional ultracentrifugation method. Elsevier 32 Jamestown Road London NW1 7BY UK www.elsevier.com Elsevier delivers reliable, relevant content, tools and support across the entire health science curriculum in ways that help educators, their students and practitioners achieve high levels of success. Trust Elsevier to offer superior resources that expand your knowledge, foster communication, enable individual and collective advancement in the healthcare field. Visit the Elsevier stand 6A where complimentary journals will be available. Elsevier, building insights, breaking boundaries! XXXIX eas2011_final.indd 39 6/10/11 9:49 AM June 26-29, 2011 European Atherosclerosis Society Administrative Executive Office Kronhusgatan 11 SE-411 05 Gothenburg Sweden www.eas-society.org The European Atherosclerosis Society (EAS) affords medical professionals access to the latest knowledge in areas including myocardial infarction, cerebro- and peripheral vascular disease. EAS organises educational activities - including our annual Congress and Advanced Courses. The Society is also active in the development and publication of Guidelines and Consensus Position Papers on atherosclerosis-related topics. The Society’s journal, Atherosclerosis, brings together from all sources papers concerned with research and investigation on atherosclerosis. EAS also supports researchers and clinicians in the field of atherosclerosis with various grants, awards and fellowships. Fresenius Medical Care Deutschland GmbH Else-Kröner-Str. 1 Bad Homburg v.d.H. 061352 Germany www.fmc-ag.com Therapeutic Apheresis is a division of Fresenius Medical Care, the world’s largest fully integrated renal healthcare company. Therapeutic Apheresis offers the possibility to treat therapy refractory patients. In patients suffering from severe hypercholesterolaemia the only effective therapy option to reduce LDL cholesterol and to improve the prognosis is LDL apheresis with DALI or MONET. Pathogenic antibodies produced by the patient’s own body are involved in many diseases. Clinical settings in which such harmful antibodies occur are various autoimmune diseases or responses to transplanted organs. Immunosorba, GLOBAFFIN in general are mainly “placed” for the treatment of various autoimmune diseases and antibody mediated transplant rejections (e.g. DCM, Pemphigus, MG, GBS, SLE, AHR). XL eas2011_final.indd 40 6/10/11 9:49 AM FINAL PROGRAMME Genzyme Corporation 500 Kendall Street Cambridge, MA 02142 USA www.genzyme.com One of the world’s leading biotechnology companies, Genzyme is dedicated to making a major positive impact on the lives of people with serious diseases. Genzyme has extensive experience in the cardiovascular field, ranging from research in cell- and gene-therapy to the commercialization of Cholestagel® (colesevelam), a therapy designed to provide an additive reduction in LDL-C in adult patients with primary hypercholesterolaemia who are not adequately controlled with a statin alone. The company’s commitment to this field continues today with the development of a novel lipid-lowering therapy for patients with severe Familial Hypercholesterolemia. Genzyme is a Sanofi company. International Atherosclerosis Society 6535 Fannin, MS A-601, Suite A754 Houston, TX 77030 USA www.athero.org The International Atherosclerosis Society (IAS), incorporated in 1979, is a Federation of 62 national or regional societies, which promotes, at an international level, the advancement of science, research, and teaching in the field of atherosclerosis. The IAS endeavors to achieve these objectives by promoting the exchange of existing knowledge; encouraging new research ventures and interdisciplinary approaches; establishing visiting fellowships for young investigators; fostering the dissemination of knowledge by organizing international symposia, workshops, courses, and meetings; and through the association with a scientific journal. We encourage you to attend the XVI International Symposium on Atherosclerosis in Sydney, Australia from 25-29 March 2012. Please visit the Symposium website for more details – www.isa2012.com To know more on the IAS please visit the IAS website: www.athero.org XLI eas2011_final.indd 41 6/10/11 9:49 AM June 26-29, 2011 Kaneka Pharma Europe N.V. (KPE) Otto-von-Guericke-Ring 13 65205 Wiesbaden Germany www.kaneka.com Kaneka Corporation Japan is touching people’s lives by enhancing its key of highly innovative technology in producing building blocks for active pharmaceutical ingredients (API), macromolecules, fermentation and bioscience. One of the main businesses of the independent subsidiary KPE is LDL-apheresis, in which Kaneka is the pioneer. Our regeneration plasma adsorber convinces by minimum of extra-corporeal volume, even perfect for pediatric treatment, with maximum of possible effect. The direct hemoperfusion column pleases by easiest handling and reduction of treatment time up to half, while keeping performance on top-class. New branches: Kaneka introduced the world’s only Ubiquinol (Kaneka QHTM), the biological active form of Coenzyme Q10. Minimum invasive interventional cardiology device will be available on the European market shortly. Kowa Pharmaceutical Europe Co Ltd. 105 Wharfedale Road Winnersh Triangle, Wokingham Berkshire RG41 5RB UK www.kowapharmaceuticals.eu Kowa Pharmaceutical Europe Co Ltd (KPE) is a UK-based specialty pharmaceutical company part of the Japanese-based Kowa group of companies. This privately owned company concentrates its efforts on the research, acquisition, development, licensing and marketing of pharmaceutical products. Its primary area of focus is cardiometabolic disease and the first product to be launched by KPE in partnership with Recordati SpA and Algorithm SAL is Livazo® (pitavastatin), a potent HMG-CoA reductase inhibitor (statin) for the treatment of primary hyperlipidemia and combined (mixed) dyslipidemia. XLII eas2011_final.indd 42 6/10/11 9:49 AM FINAL PROGRAMME Mercodia AB Sylveniusgata 8a Uppsala 754 50 Sweden www.mercodia.se Mercodia AB is a Swedish biotech company focusing on the development of immunoassays for research within the field of metabolic disorders. Our assays are applicable to both animal and human models and are used for research ranging from basic scientific studies to large pre-clinical and clinical phase trials. The company was founded in 1991 and is today a world-leading supplier of products to all major international markets. More than ninety percent of our production is exported from our facilities in Uppsala to approximately 100 different countries around the world. Mercodia provides a professional scientific support system by collaborating with customers and institutions worldwide to develop novel applications for existing products and unique diagnostics for emerging markets. MSD One Merck Drive Whitehouse Station New Jersey 08889 USA www.msd.com Today’s MSD is a global healthcare leader working to help the world be well. MSD is known as Merck in the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through farreaching policies, programs and partnerships. MSD. Be well. For more information, visit www.msd.com XLIII eas2011_final.indd 43 6/10/11 9:49 AM June 26-29, 2011 Pfizer Ltd Walton Oaks Dorking Road, Tadworth Surrey KT20 7NS UK www.pfizer.co.uk Pfizer Inc.: Working together for a healthier world™ At Pfizer, we apply science and global resources to improve health and well-being. We strive to set the standard for quality, safety and value in the discovery, development and manufacturing of medicines for people and animals. Our diversified health care portfolio includes human and animal biologic and small molecule medicines and vaccines, as well as nutritional products and many best-known consumer products. Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatment and cures for the diseases of our time. Consistent with our responsibility as the world’s leading biopharmaceutical company, we also collaborate with health care providers, governments and local communities to support access to reliable, affordable health care. Raisio Group, Benecol Division P.O. Box 101 (Raisionkaari 55) FIN-21201 Raisio Finland www.raisio.com www.benecol.net Benecol® - proven to reduce cholesterol Benecol® is the expert brand in cholesterol reduction and pioneer in cholesterol lowering food category. The brand and the unique cholesterol lowering ingredient, Plant stanol ester, used in Benecol products are owned by Raisio Group. The Benecol products are manufactured and sold by the local food companies in 30 countries on five continents. Over 60 clinical studies support the use of Benecol products as an effective, easy and safe dietary solution to lower LDL-cholesterol. Furthermore, when Benecol products are combined with statin treatment, the effects are accumulated. Benecol is on a mission to lower the world’s cholesterol. XLIV eas2011_final.indd 44 6/10/11 9:49 AM FINAL PROGRAMME Randox Laboratories 55 Diamond Road Crumlin, BT29 4QY UK www.randox.com Randox is revolutionising the early detection of cardiovascular disease. The multiplexing Cardiac Biochip Array provides rapid detection of MI and ACS, showing 20% improvement on current tests using novel markers such as H-FABP. Using the Evidence Multistat analyser, results are obtained within 20 minutes. An H-FABP immunoturbidimetric assay is available for use with a wide range of clinical analysers and provides fully quantitative results in serum within 14 minutes. Randox also offer an automated assay for evaluation of Aspirin resistance – TxB Cardio. Measuring Thromboxane levels, it provides a direct detection of Aspirin effect in apparently healthy individuals post ingestion. Roche Grenzacherstrasse 124 Basel 4070 Switzerland www.roche.com Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. The Roche CardioMetabolism Franchise is committed to developing innovative medicines to change the future for people living with cardiovascular disease and diabetes. In 2010, Roche had over 80,000 employees worldwide and invested over 9 billion Swiss francs in R&D. The Group posted sales of 47.5 billion Swiss francs. Genentech, United States, is a wholly owned member of the Roche Group. Roche has a majority stake in Chugai Pharmaceutical, Japan. XLV eas2011_final.indd 45 6/10/11 9:49 AM June 26-29, 2011 Wisepress Medical Bookshop 25 High Path, Merton Abbey London SW19 2JL UK www.wisepress.com Wisepress.com, Europe’s leading conference bookseller, has a complete range of books and journals relevant to the themes of the meeting. Books can be purchased at the stand or, if you would rather not carry them, posted to you – Wisepress will deliver worldwide. In addition to attending 200 conferences per year, Wisepress has a comprehensive medical and scientific bookshop online with great offers. Zora Biosciences Oy Biologinkuja 1 Espoo 02150 Finland www.zora.fi Zora Biosciences Oy is a biotechnology company focusing on lipidomics. Zora lipidomics is based on mass spectrometry driven lipid biochemistry and advanced bioinformatic tools. The Zora toolkit includes a broad selection of state-of-the art Lipidomic platforms. Today we routinely measure over 2000 different molecular lipid species. Zora services have been applied to pharmaceutical research and development efforts in compound selection, toxicity studies, efficacy and safety assessment among many. Zora’s own research activities are geared toward biomarker and drug target identification, with a particular focus on atherosclerosis and dyslipidemia. XLVI eas2011_final.indd 46 6/10/11 9:49 AM FINAL PROGRAMME SCIENTIFIC PROGRAMME SUNDAY, JUNE 26, 2011 XLVII 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Sunday, June 26, 2011 12:00-13:30 T. Svedberg Hall Special Session EAS GENERAL ASSEMBLY EAS Members only The EAS members’ Assembly is an opportunity for EAS members to find out more about the Society’s activities - both ongoing and forthcoming - and to put their views and questions to the Society’s elected officers. All EAS members are welcome - come, and take an active part in shaping the Society’s future. 1 Sunday, June 26, 2011 14:00-15:30 E. Nikkilä Hall Pfizer Ltd. Sponsored Educational Symposium ATORVASTATIN, AN ENDURING LEGACY Chairpersons: Germano Di Sciascio, Italy Per Tornvall, Sweden 14:00 CHAIRMAN'S INTRODUCTION Per Tornvall Sweden 14:05 ATORVASTATIN: HISTORICAL PERSPECTIVE David Waters USA 14:25 ATORVASTATIN: IMPACT ON CURRENT PRACTICE John Betteridge UK 14:40 ATORVASTATIN: CHANGING THE FUTURE OF STATIN THERAPY Pierre Amarenco France 15:00 CKD: AN EMERGING RISK FACTOR FOR CVD? Philip Kalra UK 15:15 AUDIENCE Q & A 15:25 CLOSING REMARKS Germano Di Sciascio Italy 15:30 Coffee Break 2 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Sunday, June 26, 2011 16:00-17:30 E. Nikkilä Hall F. Hoffmann-La Roche Ltd Sponsored Symposium IN FOCUS: MODIFYING CETP TO REDUCE CARDIOVASCULAR RISK? Chairpersons: Wolfgang Koenig, Germany Chris Packard, UK 16:00 CHAIRMAN'S INTRODUCTION Wolfgang Koenig Germany 16:05 HDL FUNCTION AND REVERSE CHOLESTEROL TRANSPORT IN HUMANS: CAN THEY BE PROMOTED BY THERAPEUTIC INTERVENTION? Marina Cuchel USA 16:25 THE ROLE OF REDUCED CETP ACTIVITY AS A POTENTIAL THERAPEUTIC TARGET TO DECREASE CARDIOVASCULAR EVENTS Bryan Brewer USA 16:45 VASCULAR FUNCTION - THERAPEUTIC TARGET OR CARDIOVASCULAR RISK MARKER John Deanfield UK 17:05 DISCUSSION 17:25 SUMMARY AND CLOSE Chris Packard UK 3 Sunday, June 26, 2011 16:00-17:30 T. Svedberg Hall EBAC Accredited Educational Programme: EFFECTIVE IMPLEMENTATION OF EVIDENCE-BASED CARDIOVASCULAR DISEASE PREVENTION Supported by an unrestricted educational grant from AstraZeneca Chairpersons: Andrew Tonkin, Australia Olov Wiklund, Sweden 16:00 INTRODUCTION Olov Wiklund Sweden 16:05 CHALLENGES TO EFFECTIVE CARDIOVASCULAR RISK MANAGEMENT Alberto Zambon Italy 16:20 HOT TOPICS RELATING TO THE CHALLENGES FACED IN EFFECTIVE CARDIOVASCULAR RISK MANAGEMENT All Faculty 16:30 IMPLEMENTING EFFECTIVE CVD RISK MANAGEMENT IN CLINICAL PRACTICE David Wood UK 16:45 HOT TOPICS IN THE IMPLEMENTATION OF GUIDELINES IN CLINICAL PRACTICE All Faculty 16:55 NEW OPPORTUNITIES FOR CARDIOVASCULAR DISEASE PREVENTION Stephen Nicholls USA 17:15 HOT TOPICS IN TARGETED INTERVENTION OF CVD RISK All Faculty 17:25 CLOSE Andrew Tonkin Australia 4 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Sunday, June 26, 2011 18:00-20:00 N.N. Anitschkow Hall OPENING CEREMONY INCLUDING THE ANITSCHKOW LECTURE Chairpersons: M. John Chapman, France Olov Wiklund, Sweden WELCOMING FROM THE CONGRESS CHAIRPERSON Olov Wiklund Sweden WELCOMING FROM THE THE EAS PRESIDENT M. John Chapman France WELCOMING WORDS Conny Brännberg, Sweden, First Deputy President of the Regional Council Elisabet Rothenberg, Sweden, First Deputy Lord Mayor of The City of Gothenburg Ruth Frikke-Schmidt, Denmark, Scandinavian Society for Atherosclerosis Research Musical Performance IAS AND EAS WORKING TOGETHER W. Virgil Brown USA INTRODUCTION OF THE ANITSCHKOW PRIZE WINNER M. John Chapman France THE ANITSCHKOW LECTURE: CETP INHIBITION AS A STRATEGY TO REDUCE CARDIOVASCULAR RISK Philip Barter Australia Musical Performance Followed by a Welcome Reception 5 FINAL PROGRAMME SCIENTIFIC PROGRAMME MONDAY, JUNE 27, 2011 LV eas2011_final.indd 56 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Monday, June 27, 2011 08:30-10:30 N.N. Anitschkow Hall Plenary Session: PATHOPHYSIOLOGY AND TREATMENT OF DYSLIPDEMIAS Chairpersons: W. Virgil Brown, USA Olov Wiklund, Sweden 08:30 NEW INSIGHTS INTO THE ETIOLOGY AND PATHOPHYSIOLOGY OF HEREDITARY DYSLIPIDEMIAS Helen Hobbs USA 09:00 POST-PRANDIAL LIPID METABOLISM Stephen Young USA 09:30 THE GUT MICROBIOTA AS AN ENVIRONMENTAL FACTOR THAT REGULATES HOST PHYSIOLOGY AND METABOLISM Fredrik Bäckhed Sweden 10:00 DIVERSITY OF HDL PARTICLES - A CHALLENGE FOR TREATMENT M. John Chapman France 10:30 Coffee Break and Exhibition Visit 7 eas2011_final.indd 57 6/9/11 10:07 PM Monday, June 27, 2011 11:00-12:30 N.N. Anitschkow Hall Workshop: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Chairpersons: Erik A. Biessen, The Netherlands Eva Ehrenborg, Sweden 11:00 PLAQUE ADVENTITIA: SERVICE HATCH OR BATTLEGROUND? Erik A. Biessen The Netherlands 11:25 MONOCYTE SUBSET INFILTRATION INTO THE VESSEL WALL: CRITICAL ROLE IN ATHEROSCLEROSIS PROGRESSION AND REGRESSION Stephane Potteaux France 11:50 HUMAN BIGLYCAN EXPRESSION IN A MOUSE MODEL OF ATHEROSCLEROSIS TRIGGERS LIPID RETENTION Per Fogelstrand, C. Mogensen, K. Skålén, J. Borén Sweden 12:00 SMOOTH MUSCLE CELL APOPTOSIS PROMOTES VESSEL REMODELING, VIA ACTIVATION OF CELL MIGRATION, PROLIFERATION AND COLLAGEN SYNTHESIS Haixiang Yu, M. Clarke, N. Figg, T.D. Littlewood, M.R. Bennett UK 12:10 MAJOR ROLE OF PERICYTES IN THE CALCIFICATION OF ATHEROMATOUS ARTERIES Jimmy Davaine, R. Brion, M.F. Heymann, F. Hérisson, D. Heymann, Y. Goueffic, G. Lambert France 12:20 REGRESSION AND STABILIZATION OF ADVANCED MURINE ATHEROSCLEROTIC LESIONS: A COMPARISON OF LDL LOWERING AND HDL RAISING GENE TRANSFER STRATEGIES Eline Van Craeyveld, S.C. Gordts, E. Nefyodova, F. Jacobs, B. De Geest Belgium 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area 8 eas2011_final.indd 58 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 11:00-12:30 E. Nikkilä Hall Workshop: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS Chairpersons: Marja-Riitta Taskinen, Finland Bo Angelin, Sweden 11:00 REMNANT LIPOPROTEIN RECEPTORS AND THEIR DYSREGULATION BY DIABETES Kevin Jon Williams USA 11:25 MECHANISMS UNDERLYING THE ATHEROGENIC LIPID TRIAD IN INTRAABDOMINAL OBESITY AND INSULIN RESISTANCE Marja-Riitta Taskinen Finland 11:50 THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST EXENDIN-4 INHIBITS VLDL BIOSYNTHESIS AND SECRETION IN APOE*3-LEIDEN MICE Y. Wang, E.T. Parlevliet, J.J. Geerling, J.P. Schröder-Van der Elst, J.W.A. Smit, L.M. Havekes, J.A. Romijn, H. Pijl, Patrick C.N. Rensen The Netherlands 12:00 POSTPRANDIAL TRIGLYCERIDE METABOLISM IS IMPAIRED IN STATIN-TREATED TYPE 2 DIABETIC MEN H. Barrett, J. Pang, V. Tenneti, D. Chan, Gerald F. Watts Australia 12:10 ORP10, A NOVEL REGULATOR OF LIPOGENESIS AND APOB100 SECRETION Eija Nissilä, G. Liebisch, Y. Zhou, J. Perttilä, G. Schmitz, V.M. Olkkonen Finland 12:20 ALIPOGENE TIPARVOVEC GENE THERAPY ENHANCES POST-PRANDIAL CLEARANCE OF CHYLOMICRONS IN LIPOPROTEIN LIPASE DEFICIENT PATIENTS A.C. Carpentier, F. Frisch, S.M. Labbé, J. Méthot, C. Gagné, S. Déry, K. Tremblay, Janneke de Wal, J. Twisk, S. Greentree, N. van den Bulk, D. Brisson, D. Gaudet The Netherlands 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area Lipids, Lipoproteins and Lipid Metabolism Monday, June 27, 2011 9 eas2011_final.indd 59 6/9/11 10:07 PM Monday, June 27, 2011 11:00-12:30 T. Svedberg Hall Joint EAS - EACPR Workshop: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION Chairpersons: Helena Gylling, Finland Joep Perk, Sweden THE ROLE OF DIET COMPOSITION FOR PREVENTION OF CVD DISEASE WITH FOCUS ON DIETARY FATS Tine Tholstrup Denmark 11:20 PLANT STANOLS AND STEROLS: AN EXAMPLE OF FUNCTIONAL FOODS AND CARDIOVASCULAR DISEASE Helena Gylling Finland 11:40 DO WE NEED NEW CLINICAL TRIALS ON N3 PUFA IN CARDIOVASCULAR DISEASE? Roberto Marchioli Italy 12:00 HEALTHY DIET: WHAT DO THE NEW JOINT EUROPEAN GUIDELINES ON CVD PREVENTION SAY? Joep Perk Sweden 12:20 DISCUSSION 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area Diagnosis, Prevention and Treatment of Cardiovascular Disease 11:00 eas2011_final.indd 60 10 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Monday, June 27, 2011 11:00-12:30 C. Müller Hall Joint EAS-ESC Workshop: THROMBOGENIC RISK FACTORS FOR ATHEROTHROMBOSIS AND ACUTE CORONARY EVENTS Karl Swedberg, Sweden Lars Wallentin, Sweden 11:00 ANTIPHOSPHOLIPID ANTIBODIES, A RISK FACTOR FOR ATHEROTHROMBOSIS? Philip G. de Groot The Netherlands 11:20 GENETIC AND BIOMARKER RISK FACTORS IN ACUTE CORONARY SYNDROMES Lars Wallentin Sweden 11:40 NEW CHALLENGES IN TREATMENT OF ACUTE CORONARY SYNDROMES Nicolas Danchin France 12:00 ROLE OF CO-MORBIDITIES: ANAEMIA, RENAL DYSFUNCTION AND LOW GRADE INFLAMMATION Felicita Andreotti Italy 12:20 DISCUSSION 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area Genetics, Risk Factors and Epidemiology- from Population to Patients Chairpersons: 11 eas2011_final.indd 61 6/9/11 10:07 PM Monday, June 27, 2011 12:45-14:15 E. Nikkilä Hall EBAC Accredited Educational Programme: NUTRITIONAL BEHAVIOUR & REDUCTION OF CARDIOVASCULAR RISK: FROM BASIC SCIENCE TO CLINICAL PRACTICE Supported by an unrestricted educational grant from Danone Chairpersons: M. John Chapman, France John Deanfield, UK 12:45 INTRODUCTION: OBJECTIVES OF THE EDUCATIONAL SYMPOSIUM AND KEY QUESTIONS M. John Chapman, France John Deanfield, UK 12:50 NEW BASIC INSIGHTS IN TASTE BUD CELLS BIOLOGY: LIPID SENSING AND EATING BEHAVIOR Philippe Besnard France 13:10 WHAT TOOLS TO SUPPORT DIETARY MODIFICATION IN OUR PATIENTS? Eric Bruckert France 13:30 DIETARY ADVICE AS A DRIVER OF MODIFICATION IN NUTRITIONAL BEHAVIOUR: THE RECIPE STUDY Luis Masana Spain 13:50 LIFETIME CARDIOVASCULAR RISK: KEY COMPONENTS John Deanfield UK 14:10 PANEL DISCUSSION & CONCLUSION 12 eas2011_final.indd 62 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Monday, June 27, 2011 15:00-16:30 N.N. Anitschkow Hall Workshop: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS Bente Halvorsen, Norway Andrew Newby, UK 15:00 IMMUNE REGULATION OF MACROPHAGE PHENOTYPE Andrew Newby UK 15:25 CHEMOKINES IN ATHEROGENIC LEUKOCYTE RECRUITMENT AND HOMEOSTATIS Christian Weber Germany 15:50 LACK OF ANTIGEN PRESENTATION ON MHC CLASS II AGGRAVATES ATHEROSCLEROSIS IN APOE-/- MICE Maria Wigren, H. Björkbacka, G.N. Fredrikson, J. Nilsson Sweden 16:00 CD4+ NKT CELLS CONTRIBUTE TO ATHEROSCLEROSIS VIA PERFORIN- AND GRANZYME B-DEPENDENT CYTOTOXIC MECHANISMS K. To, Alexander Bobik, P. Tipping, B.H. Toh Australia 16:10 THE EXPRESSION OF TLR3 IS INCREASED IN ATHEROSCLEROSIS AND MEDIATES PROTECTION AGAINST LESION DEVELOPMENT AND WEIGHT GAIN IN APOE-/MICE Jennifer E. Cole, T. Navin, A.J. Cross, M.E. Goddard, L. Alexopoulou, A.T. Mitra, A.H. Davies, R.A. Flavell, M. Feldmann, C. Monaco UK 16:20 IDENTIFICATION OF A DANGER-ASSOCIATED PEPTIDE FROM APOLIPOPROTEIN B100 (APOBDS-1) THAT TRIGGERS INNATE PRO-ATHEROGENIC RESPONSES Daniel F.J. Ketelhuth, F.J. Rios, H. Liu, Y. Wang, M.E. Johansson, G.N. Fredrikson, M. Gidlund, J. Nilsson, G.K. Hansson, Z.Q. Yan Sweden 16:30 Coffee Break and Exhibition Visit From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Chairpersons: 13 eas2011_final.indd 63 6/9/11 10:07 PM Lipids, Lipoproteins and Lipid Metabolism Monday, June 27, 2011 15:00-16:30 E. Nikkilä Hall Workshop: CELLULAR LIPID, METABOLISM, FROM UPTAKE TO STORAGE Chairpersons: Jan Borén, Sweden Jan F.C. Glatz, The Netherlands 15:00 LIPID DROPLETS AND THEIR RELATION TO THE DEVELOPMENT OF INSULIN RESISTANCE Sven-Olof Olofsson Sweden 15:25 MEMBRANE FATTY ACID TRANSPORTERS REGULATE CELLULAR LIPID METABOLISM: IMPLICATIONS FOR METABOLIC DISEASE Jan F.C. Glatz The Netherlands 15:50 HOW BROWN ADIPOSE TISSUE CORRECTS HYPERLIPIDEMIA AND OBESITY: A ROLE FOR LIPOPROTEINS Alexander Bartelt, O.T. Bruns, H. Ittrich, A. Niemeier, M. Merkel, J. Heeren Germany 16:00 ROLE OF HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 (ANGPTL3) GLYCOSYLATION IN THE PROTEIN SECRETION AND STABILITY Maria Antonella Burza, C. Pirazzi, C. Maglio, A. Molinaro, S. Ginanni Corradini, S. Romeo UK, Italy 16:10 THE VLDL RECEPTOR PROMOTES LIPOTOXICITY AND INCREASES MORTALITY IN MICE FOLLOWING AN ACUTE MYOCARDIAL INFARCTION Jeanna Perman, J. Borén Sweden 16:20 SKELETAL-MUSCLE LIPOPROTEIN EXPRESSION IS REGULATED BY TRAINING AND TYPE 2 DIABETES IN HUMANS AND IMPROVES INSULIN SENSITIVITY IN OBESE MICE Emil Bartels, T. Ploug, J. Størling, T. Mandrup-Poulsen, F. Dela, L.B. Nielsen Denmark 16:30 Coffee Break and Exhibition Visit 14 eas2011_final.indd 64 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Monday, June 27, 2011 15:00-15:40 T. Svedberg Hall How To Session: HOW TO USE LIPIDOMICS IN ATHEROSCLEROTIC RESEARCH Chairperson: Magnus Bäck, Sweden HOW TO USE LIPIDOMICS IN ATHEROSCLEROTIC RESEARCH Edward Dennis USA 15:00-15:40 C. Müller Hall How To Session: HOW TO EVALUATE LIPOPROTEIN (a) IN THE CLINIC AND IN SCIENCE Chairperson: Børge Nordestgard, Denmark HOW TO EVALUATE LIPOPROTEIN(a) IN THE CLINIC AND IN SCIENCE Sotirios Tsimikas, USA Børge Nordestgaard, Denmark 15 eas2011_final.indd 65 6/9/11 10:07 PM Monday, June 27, 2011 15:45-16:30 T. Svedberg Hall How To Session: HOW TO MANAGE CARDIOVASCULAR RISK IN PATIENTS WITH CHRONIC KIDNEY DISEASE Chairperson: Lars-Bo Nielsen, Denmark CHRONIC KIDNEY DISEASE - A PUBLIC HEALTH PRIORITY AND HARBINGER OF PREMATURE CARDIOVASCULAR DISEASE Peter Stenvinkel Sweden 16:30 Coffee Break and Exhibition Visit 15:45-16:30 C. Müller Hall How To Session: How To Session: HOW TO DIAGNOSE AND SCREEN FOR FAMILIAL HYPERLIPIDEMIA Chairperson: Mats Eriksson, Sweden HOW TO DIAGNOSE AND SCREEN FOR FAMILIAL HYPERLIPIDEMIA Emilio Ros Spain THE IMPORTANCE OF A GENETIC DIAGNOSIS OF FAMILIAL HYOERCHOLESTEROLEMIA Joep Defesche The Netherlands 16:30 Coffee Break and Exhibition Visit 16 eas2011_final.indd 66 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Monday, June 27, 2011 17:00-18:30 E. Nikkilä Hall MSD Sponsored Educational Symposium: NEW ADVANCES IN CARDIOVASCULAR RISK REDUCTION IN HIGH-RISK PATIENTS Chairperson: Marja-Riitta Taskinen, Finland 17:00 WELCOME AND OPENING REMARKS Marja-Riitta Taskinen Finland 17:05 UNMET MEDICAL NEED IN TREATMENT OF HIGH-RISK PATIENT POPULATIONS Ronnie Willenheimer Sweden 17:20 EFFECTIVE TREATMENT OPTIONS WITH ADD-ODD OR COMBINATION THERAPY Michel Farnier France 17:45 INSIGHTS FROM SHARP STUDY RESULTS Martin Landray UK 18:10 PATIENT CASE STUDIES & PANEL DISCUSSION: THERAPEUTIC CHOICES IN HIGH RISK PATIENTS Anslem Gitt Germany 18:25 CLOSING REMARKS Marja-Riitta Taskinen Finland 17 eas2011_final.indd 67 6/9/11 10:07 PM Monday, June 27, 2011 17:00-18:30 T. Svedberg Hall Genzyme Sponsored Educational Symposium: SEVERE FAMILIAL HYPERCHOLESTEROLEMIA, A GENETIC DISEASE THAT NEEDS AGGRESSIVE TREATMENT Chairperson: Erik Stroes, The Netherlands 17:00 WELCOME, MEETING OBJECTIVES AND OPENING REMARKS Erik Stroes The Netherlands 17:05 SCREENING AND DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLEMIA WITH IDENTIFICATION OF PATIENTS WITH SEVERE FH Rodrigo Alonso Spain 17:25 LP(a) IN FAMILIAL HYPERCHOLESTEROLEMIA: IMPORTANCE OF LOOKING BEYOND LDL-C LOWERING Sotirios Tsimikas USA 17:50 CURRENT AND NEW TREATMENT MODALITIES FOR PATIENTS WITH SEVERE FH Klaus Parhofer Germany 18:10 PANEL DISCUSSION Faculty 18:25 TAKE-HOME MESSAGES AND CLOSING REMARKS Erik Stroes The Netherlands 18 eas2011_final.indd 68 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 SCIENTIFIC PROGRAMME TUESDAY, JUNE 28, 2011 eas2011_final.indd 69 6/9/11 10:07 PM June 26-29, 2011 LXX eas2011_final.indd 70 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Tuesday, June 28, 2011 08:30-10:30 N.N. Anitschkow Hall Plenary Session: HOW TO FIND AND TREAT THE VULNERABLE PLAQUE Chairpersons: Petri Kovanen, Finland Andrew Newby, UK 08:30 PATHOLOGY OF THE VULNERABLE PLAQUE: WHAT DOES IT LOOK LIKE? Erling Falk Denmark 09:00 THE CELLULAR BIOLOGY OF PLAQUE NECROSIS Ira Tabas USA 09:30 NEW IMAGING POSSIBILITIES IN ATHEROSCLEROSIS James Rudd UK 10:00 PHARMACOLOGICAL TREATMENT OF THE VULNERABLE PLAQUE Peter Libby USA 10:30 Coffee Break and Exhibition Visit 19 eas2011_final.indd 71 6/9/11 10:07 PM Lipids, Lipoproteins and Lipid Metabolism Tuesday, June 28, 2011 11:00-12:30 N.N. Anitschkow Hall Workshop: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL Chairpersons: Arnold von Eckardstein, Switzerland Ruth Frikke-Schmidt, Denmark 11:00 INFLAMMATORY REMODELLING GENERATES DYSFUNCTIONAL HDL Jay W. Heinecke USA 11:25 THE ENDOTHELIUM AS A BARRIER AND TARGET OF HDL'S ANTI-ATHEROGENICTY Arnold von Eckardstein Switzerland 11:50 THE PLASMA CONCENTRATION OF HDL-ASSOCIATED APOM IS CONTROLLED BY THE ACTIVITY OF THE LDL-RECEPTOR Christina Christoffersen, M. Benn, R. Frikke-Schmidt, A. Tybjaerg-Hansen, B. Dahlbäck, L.B. Nielsen Denmark 12:00 ROLE OF ENDOTHELIAL LIPASE IN HDL METABOLISM AND ATHEROSCLEROSIS IN HUMANS Tatsuro Ishida, T. Yasuda, L. Sun, K.-I. Hirata Japan 12:10 KRP-206, A SELECTIVE S1P(1) AGONIST INHIBITS DEVELOPMENT OF ATHEROSCLEROSIS IN LOW-DENSITY LIPOPROTEIN RECEPTOR-DEFICIENT MICE Sara Costa, F. Poti, V. Bergonzini, M. Galletti, H. Freise, G. Varga, M. Simoni, J.-R. Nofer Italy 12:20 LCAT, HDL CHOLESTEROL AND MYOCARDIAL INFARCTION - A MENDELIAN RANDOMIZATION STUDY OF HDL CHOLESTEROL IN 54,500 INDIVIDUALS Christiane L. Haase, A. Tybjærg-Hansen, A.A. Qayyum, J. Schou, B.G. Nordestgaard, R. Frikke-Schmidt Denmark 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area 20 eas2011_final.indd 72 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Tuesday, June 28, 2011 11:00-12:30 E. Nikkilä Hall Workshop: BIOMARKERS FROM BENCH TO BEDSIDE Gerard Pasterkamp, The Netherlands Anders Hamsten, Sweden 11:00 CARDIOVASCULAR BIOMARKERS FOR RISK STRATIFICATION AND THERAPY GUIDANCE Stefan Blankenberg Germany 11:25 INNOVATION IN BIOMARKER DISCOVERY Gerard Pasterkamp The Netherlands 11:50 COMPREHENSIVE METABOLIC PROFILING IMPROVES PREDICTION OF SUBCLINICAL ATHEROSCLEROSIS IN YOUNG ADULTS Peter Würtz, J. Raiko, C.G. Magnussen, P. Soininen, A.J. Kangas, T. Tynkkynen, R. Thomson, R. Laatikainen, M.J. Savolainen, A. Jula, J.S. Viikari, M. Kähönen, T. Lehtimäki, M. Juonala, M. Ala-Korpela, O.T. Raitakari Finland 12:00 BIOLOGICAL ROLES OF THE SECRETED SOLUBLE FORM OF LR11/SORLA Wolfgang Schneider, H. Bujo, M. Jiang, K. Ohwaki, Y. Saito Austria 12:10 GENETIC POLYMORPHISMS OF THE MAIN TRANSCRIPTION FACTORS FOR ADIPONECTIN GENE PROMOTER IN REGULATION OF PLASMA ADIPONECTIN LEVEL Lyudmyla Kedenko, C. Lamina, I. Kedenko, F. Kronenberg, B. Paulweber Austria 12:20 SENSITIVE BIOMARKER FOR STATIN-INDUCED MYOTOXICITY Reijo Laaksonen, K. Tarasov, D. Kauhanen, T. Sylvänne, M. Jänis, R. Hurme, K. Ekroos, G. Mombelli, C. Sirtori, J.C. Tardif Finland 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area Genetics, Risk Factors and Epidemiology- from Population to Patients Chairpersons: 21 eas2011_final.indd 73 6/9/11 10:07 PM Tuesday, June 28, 2011 11:00-12:30 T. Svedberg Hall Workshop: HYPOXIA AND ANGIOGENESIS IN THE PLAQUE From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Chairpersons: Mat Daemen, The Netherlands Lillemor Mattsson Hultén, Sweden 11:00 CELL-CELL SIGNALING IN THE REGULATION OF ANGIOGENESIS AND VASCULAR PERMEABILITY Christer Betsholtz Sweden 11:30 FROM THE VULNERABLE PLAQUE TO THE VULNERABLE PATIENT-CHALLENGES FOR TRANSATIONAL MEDICINE Mat Daemen The Netherlands 12:00 LACTATE AS AN ATHEROSCLEROTIC PLAQUE MARKER FOR HYPOXIA Sandra Margaretha Bovens, G. Zomer, A. Vink, G. Pasterkamp The Netherlands 12:10 ACIDITY INCREASES THE UPTAKE OF NATIVE LDL BY HUMAN MONOCYTEDERIVED MACROPHAGES Katariina Öörni, R. Plihtari, P.T. Kovanen Finland 12:20 POSITIVE CROSS-TALK BETWEEN HYPOXIA INDUCIBLE FACTOR-1Α AND LIVER X RECEPTOR Α INDUCES FORMATION OF TRIGLYCERIDE-LOADED FOAM CELLS Tae-Young Na, M.O. Lee Republic of Korea 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area 22 eas2011_final.indd 74 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Tuesday, June 28, 2011 11:00-12:30 C. Müller Hall Workshop: CEREBROVASCULAR AND CAROTID DISEASE –PREDICTION, PREVENTION AND TREATMENT Markku Kaste, Finland S. Lale Tokgözoglu, Turkey 11:00 DETECTION, EVALUATION AND TREATMENT OF CAROTID STENOSES Per Wester Sweden 11:25 HOW TO PREVENT AND TREAT STROKE Markku Kaste Finland 11:50 RISK FACTORS, BIOMARKERS AND PROGNOSIS IN DIFFERENT ETIOLOGIC SUBTYPES OF ISCHEMIC STROKE - RESULTS FROM THE SAHLGRENSKA ACADEMY STUDY IN ISCHEMIC STROKE (SAHLSIS) Christina Jern Sweden 12:10 DURATION OF TYPE 2 DIABETES STRONGLY PREDICTS ALL-CAUSE MORTALITY, CARDIOVASCULAR MORTALITY AND DEATH FROM STROKE IN SUBJECTS UNDERGOING CORONARY ANGIOGRAPHY Guenther Silbernagel, S. Rosinger, T.B. Grammer, B.R. Winkelmann, B.O. Boehm, W. März Germany 12:20 ASYMPTOMATIC CAROTID ARTERY DISEASE IN VALVULAR HEART SURGERY Amedeo Anselmi, M. Morelli, C. Pragliola, N. Pavone, V. Tsiopoulos, F. Glieca, M. Gaudino Italy 12:30 Poster Presentations and Light Buffet 12:40 Meet the Speaker Sessions in the Poster Area 23 eas2011_final.indd 75 Diagnosis, Prevention and Treatment of Cardiovascular Disease Chairpersons: 6/9/11 10:07 PM Tuesday, June 28, 2011 13:50-14:30 C. Müller Hall Special Lecture: Supported by an unrestricted educational grant from Aegerion Chairperson: 13:50 Sven-Olof Olofsson, Sweden THE ROLE OF MTP IN LIPOPROTEIN ASSEMBLY AND IN THE DEVELOPMENT OF NOVEL THERAPEUTIC APPROACHES Marina Cuchel USA 24 eas2011_final.indd 76 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Tuesday, June 28, 2011 15:00-16:30 N.N. Anitschkow Hall Joint EAS-ICCR Workshop: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT Thomas Lüscher, Switzerland Philip Barter, Australia 15:00 VASCULAR EFFECTS OF HDL: ROLE OF LIPOPROTEIN DYSFUNCTION Thomas Lüscher Switzerland 15:20 ANTISENSE THERAPY IN METABOLIC DYSLIPIDEMIA Erik Stroes The Netherlands 15:40 MOLECULAR IMAGING OF ARTERIAL INFLAMMATION Peter Libby USA 16:00 CARDIOMETABOLIC RISK AND SUBCLINICAL ATHEROSCLEROSIS IN YOUNG ADULTS Eric Larose Canada 16:20 DISCUSSION Philip Barter Australia 16:30 Coffee Break and Exhibition Visit 25 eas2011_final.indd 77 Diagnosis, Prevention and Treatment of Cardiovascular Disease Chairpersons: 6/9/11 10:07 PM Tuesday, June 28, 2011 15:00-16:30 E. Nikkilä Hall Special Session: LATE BREAKING SESSION Chairpersons: Alberico Catapano, Italy Andrew Newby, UK 15:00 LIPID-LOWERING EFFECTS OF THE THYROID HORMONE ANALOGUE EPROTIROME REQUIRES FUNCTIONAL LDL RECEPTORS: STUDIES IN A HOMOZYGOUS FH PATIENT Peter Benedek, B. Angelin, J. Kristensen, M. Rudling, M. Eriksson Sweden 15:12 NONFASTING GLUCOSE AND ISCHEMIC HEART DISEASE - A MENDELIAN RANDOMIZATION APPROACH Marianne Benn, A. Tybjærg-Hansen, M.I. McCarthy, G.B. Jensen, P. Grande, B.G. Nordestgaard Denmark 15:24 TRIGLYCERIDE-RICH LIPOPROTEINS AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN PATIENTS AT HIGH RISK OF CARDIOVASCULAR DISEASE: EVIDENCE AND GUIDANCE FOR MANAGEMENT M. John Chapman, H.N. Ginsberg, P. Amarenco, F. Andreotti, J. Borén, A. Catapano, O.S. Descamps, E. Fisher, P. Kovanen, J.A. Kuivenhoven, P. Lesnik, L. Masana, B.G. Nordestgaard, K. Ray, Z. Reiner, M.-R. Taskinen, L. Tokgözoglu, A. Tybjærg-Hansen, G.F. Watts, The European Atherosclerosis Society Consensus Panel France 15:36 PLANT STEROLS AND CARDIOVASCULAR DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS Winfried März, G. Silbernagel, G. De Backer, E. Bruckert, R. Carmena, J. Chapman, J. Deanfield, O.S. Descamps, E.R. Rietzschel, K.C. Dias, B. Genser Germany, Austria 15:48 APOLIPOPROTEIN AV INTERNALIZED IN HUMAN ADIPOCYTE MODULATES CELLULAR TRIGLYCERIDE ACCUMULATION X.-Y. Zheng, Shui-Ping Zhao, B.-L. Yu, C.-L. Wu, L. Liu China 16:00 ALIPOGENE TIPARVOVEC GENE THERAPY SIGNIFICANTLY REDUCES THE RISK OF PANCREATITIS IN LIPOPROTEIN LIPASE DEFICIENT PATIENTS Stephen Greentree, J. Méthot, S. Déry, K. Tremblay, J. de Wal, N. van den Bulk, G. Ruiterkamp, A. Freidig, D. Brisson, D. Gaudet The Netherlands 16:12 DISCUSSION 16:30 Coffee Break and Exhibition Visit 26 eas2011_final.indd 78 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Tuesday, June 28, 2011 15:00-16:30 T. Svedberg Hall Workshop: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFESTYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE Annika Rosengren, Sweden Göran Bondjers, Sweden 15:00 PSYCHOSOCIAL STRESS - A CASUAL FACTOR IN THE ETIOLOGY OF CVD? Annika Rosengren Sweden 15:30 LOW SOCIOECONOMIC STATUS AND STRESS-RELATED CARDIOVASCULAR AND INFLAMMATORY RESPONSES Andrew Steptoe UK 16:00 SOCIAL DISRUPTION STRESS ACCELERATES ATHEROSCLEROSIS IN APOE-/MICE Maria E. Johansson, E. Bernberg, M.A. Ulleryd, G.M. Bergström Sweden 16:10 DEPRESSION SCORES PREDICT ADHERENCE IN A DIETARY WEIGHT LOSS INTERVENTION TRIAL. Shawn Somerset, L. Graham, K. Markwell Australia 16:20 CAN SKINFOLD THICKNESS PREDICT CARDIO-VASCULAR RISK FACTORS IN YOUTHS? Peter Schwandt, E. Liepold, G.M. Haas Germany 16:30 Coffee Break and Exhibition Visit Genetics, Risk Factors and Epidemiology- from Population to Patients Chairpersons: 27 eas2011_final.indd 79 6/9/11 10:07 PM Tuesday, June 28, 2011 15:00-15:40 C. Müller Hall Special Lecture: Supported by an unrestricted educational grant from MSD Chairpersons: 15:00 Jan Borén, Sweden Olov Wiklund, Sweden CETP INHIBITION: THE NEXT FRONTIER IN CARDIOVASCULAR THERAPY Bryan Brewer USA 15:45-16:15 C. Müller Hall Special Session: YOUNG INVESTOR AWARD CEREMONY Chairpersons: Petri Kovanen, Finland Bart Staels, France 15:45 DNA DAMAGE LINKS MITOCHONDRIAL DYSFUNCTION TO ATHEROSCLEROSIS AND THE METABOLIC SYNDROME John Mercer UK 15:55 AUGMENTED EXPRESSION AND ACTIVITY OF EXTRACELLULAR MATRIXDEGRADING ENZYMES IN REGIONS OF LOW ENDOTHELIAL SHEAR STRESS COLOCALIZE WITH CORONARY ATHEROMATA WITH THIN FIBROUS CAPS IN PIGS Yiannis Chatzizisis USA 16:30 Coffee Break and Exhibition Visit 28 eas2011_final.indd 80 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Tuesday, June 28, 2011 17:00-18:30 E. Nikkilä Hall EBAC Accredited Educational Programme: NOVEL STRATEGIES FOR RAISING HDL-C: PITAVASTATIN IN CLINICAL PRACTICE Supported by an unrestricted educational grant from Kowa Pharmaceutical Europe Co Ltd. Chairpersons: Philip Barter, Australia Yasushi Saito, Japan 17:00 CO-CHAIR'S INTRODUCTION Philip Barter, Australia Yasushi Saito, Japan 17:05 HDL-C: ROLE AS A RISK MODIFIER Philip Barter Australia 17:25 PITAVASTATIN - AN OVERVIEW Yasushi Saito Japan 17:35 PITAVASTATIN: NOVEL EFFECTS ON LIPID PARAMETERS M. John Chapman France 17:55 PITAVASTATIN: CLINICAL EFFECTS FROM THE LIVES STUDY Tamio Teramoto Japan 18:15 AUDIENCE Q & A Philip Barter, Australia Yasushi Saito, Japan 18:30 SUMMARY Philip Barter Australia 29 eas2011_final.indd 81 6/9/11 10:07 PM Tuesday, June 28, 2011 17:00-18:30 T. Svedberg Hall InterCHol FH Symposium: WHAT’S NEW IN MANAGING CHILDREN WITH FH FRESH SCREENING METHODS AND OPTIONS In appreciation of Roger Williams and MEDPED Chairpersons: W. Virgil Brown, USA Joep Defesche, The Netherlands 17:00 WELCOME AND OPENING REMARKS W. Virgil Brown USA 17:10 NEW SCREENING METHODS AND TREATMENT OPTIONS FOR CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA. Albert Wiegman The Netherlands 17:35 DO CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA BENEFIT FROM DIET? Kurt Widhalm Austria 18:00 PEDIATRIC SCREENING FOR FAMILIAL HYPERCHOLESTERLEMIA IN EUROPE. Leiv Ose Norway 18:25 CONCLUSIONS AND CLOSE BY CHAIRMEN W. Virgil Brown, USA Joep Defesche, The Netherlands 17:00-17:40 C. Müller Hall Special Lecture: Supported by an unrestricted educational grant from Boehringer Ingelheim Chairperson: Marja-Riitta Taskinen, Finland CARDIOVASCULAR RISK IN DIABETES: NEW THERAPEUTIC APPROACHES Michaela Diamant The Netherlands 30 eas2011_final.indd 82 6/9/11 10:07 PM FINAL PROGRAMME SCIENTIFIC PROGRAMME WEDNESDAY, JUNE 29, 2011 LXXXIII eas2011_final.indd 83 6/9/11 10:07 PM June 26-29, 2011 LXXXIV eas2011_final.indd 84 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Wednesday, June 29, 2011 08:30-10:30 N.N. Anitschkow Hall Plenary Session: PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE Chairpersons: Terje Pedersen, Norway Zeljko Reiner, Croatia 08:30 THE ROLE OF INFLAMMATORY BIOMARKERS IN DAILY DECISION MAKING Børge Nordestgaard Denmark 09:00 IMMUNE MODULATION/VACCINATION TO TREAT AND PREVENT ATHEROSCLEROSIS Jan Nilsson Sweden 09:30 WHAT IS A HEALTHY DIET, AS DEFINED BY THE CRITERIA OF EVIDENCE-BASED MEDICINE? Gabriele Riccardi Italy 10:00 THE NEW EAS/ESC GUIDLINES TO TREAT DYSLIPIDEMIAS Alberico Catapano Italy 10:30 Coffee Break and Exhibition Visit 31 eas2011_final.indd 85 6/9/11 10:07 PM Wednesday, June 29, 2011 11:00-12:30 N.N. Anitschkow Hall Workshop: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING Chairpersons: Robin P. Choudhury, UK Lars Johansson, Sweden IMAGING AND TARGETED DRUG IN ATHEROSCLEROSIS Zahi A. Fayad USA 11:30 MOLECULAR MR IMAGING IN ATHEROSCLEROSIS Robin P. Choudhury UK 12:00 IMPACT OF OPTICAL COHERENCE TOMOGRAPHY (OCT), INTEGRATEDBACKSCATTER-IVUS (IB-IVUS), AND 64-SLICE MULTIDETECTOR CT (64-SLICE MDCT) ON ACS AND STABLE LESION CHARACTERISTICS Yukio Ozaki, M. Okumura, K. Hattori, H. Naruse, S.C. Kan, M. Ohota, H. Harigaya, H. Kawai, M. Ishikawa, T. Hashimoto, J. Ishii Japan 12:10 NON-INVASIVE MOLECULAR IMAGING USING CONTRAST ENHANCED ULTRASOUND FOR DETECTION OF ARTERIAL THROMBOSIS VIA SINGLE-CHAIN ANTIBODY-TARGETED MICROBUBBLES Xiaowei Wang, C.E. Hagemeyer, F. Jia, E. Leitner, I. Ahrens, K. Peter Australia 12:20 DISCUSSION Diagnosis, Prevention and Treatment of Cardiovascular Disease 11:00 eas2011_final.indd 86 32 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Wednesday, June 29, 2011 11:00-12:30 E. Nikkilä Hall Workshop: NOVEL GENES RELATED TO ATHEROGENESIS AND LIPID METABOLISM – DO THEY INCREASE OUR UNDERSTANDING OF THE DISEASE? Steve Humphries, UK Anne Tybjærg-Hansen, Denmark 11:00 A MULTI-LOCUS GENETIC RISK SCORE AND RISK FOR INCIDENT CORONARY HEART DISEASE Sekar Kathiresan USA 11:25 USING GENES TO DETERMINE CAUSALITY FOR ISCHEMIC HEART DISEASE Anne Tybjærg-Hansen Denmark 11:50 GENETIC VARIATION IN TRANSTHYRETIN, LIPID AND LIPOPROTEIN LEVELS, AND RISK OF ISCHEMIC VASCULAR DISEASE Louise Hornstrup, C.L. Haase, R. Frikke-Schmidt, A. Tybjærg-Hansen Denmark 12:00 IDENTIFICATION OF TWO NEW MUTATIONS OF GPIHBP1 IN SEVERE HYPERCHYLOMICRONEMIA Sybil Charriere, N. Peretti, S. Bernard, M. Charcosset, A. Sassolas, A. Lachaux, P. Moulin, C. Marçais France 12:10 NEW GAIN OF FUNCTIONS MUTATIONS IN PCSK9 AND THEIR IMPACT IN FAMILIAL HYPERCHOLESTEROLEMIA Marianne AbiFadel, J.P. Rabès, M. Guérin, V. Carreau, A. Carrié, M. Varret, M.E. Samson-Bouma, L. Tosolini, D. Erlich, P. Couvert, D. Bonnefont-Rousselot, E. Bruckert, A. Prat, N. Seidah, C. Boileau France , Lebanon 12:20 -203A/C POLYMORPHISM OF CHOLESTEROL 7- α HYDROXYLASE (CYP7A1) GENE AFFECTS CYP7A1 ACTIVITY AFTER SHORT-TERM TREATMENT WITH CHOLESTYRAMINE Jan Kovar, M. Zimolova, M. Lenicek, L. Vitek, M. Jirsa, R. Poledne Czech Republic Genetics, Risk Factors and Epidemiology- from Population to Patients Chairpersons: 33 eas2011_final.indd 87 6/9/11 10:07 PM Lipids, Lipoproteins and Lipid Metabolism Wednesday, June 29, 2011 11:00-12:30 T. Svedberg Hall Workshop: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES Chairpersons: Eva Hurt-Camejo, Sweden Norbert Leitinger, USA 11:00 OXIDIZED PHOSPHOLIPIDS AND MACROPHAGE PHENOTYPIC POLARIZATION Norbert Leitinger USA 11:25 LEUKOTRIENES IN CARDIOVASCULAR DISEASES Jesper Haeggström Sweden 11:50 ACYL CHAIN-DEPENDENT EFFECT OF LYSOPHOSPHATIDYLCHOLINES ON COX-2 EXPRESSION IN VASCULAR ENDOTHELIAL CELLS Lada Brkic, M. Riederer, R. Malli, W. Graier, S. Frank Austria 12:00 LIPID ALDEHYDE-MODIFIED AMINOPHOSPHOLIPIDS INDUCE ER STRESS AND ACTIVATE THE INFLAMMATORY RESPONSE OF ENDOTHELIAL CELLS Sean Stephen Davies, L. Guo, Z. Chen, B.E. Cox, V. Amarnath, R.F. Epand, R.M. Epand USA 12:10 ALOX15B IS THE MAJOR 15-LIPOXYGENASE IN HUMAN MACROPHAGES S. Wüst, M. Crucet, M. Herová, Martin Hersberger Switzerland 12:20 INHIBITION OF ALOX15B REDUCES INFLAMMATION IN ATHEROSCLEROSIS-PRONE MICE Lillemor Mattsson Hultén, A. Lundqvist, M.N. Karlsson, K. Skålén, O. Wiklund, L. Magnusson Sweden 34 eas2011_final.indd 88 6/9/11 10:07 PM 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Wednesday, June 29, 2011 11:00-12:30 C. Müller Hall Workshop: NUCLEAR RECEPTORS AT THE CROSSROAD OF LIPID METABOLISM AND INFLAMMATION Bart Staels, France Marten Hofker, The Netherlands 11:00 NUCLEAR RECEPTOR CONTROL OF MACROPHAGE FUNCTIONS Bart Staels France 11:25 STEROL AND OXYSTEROL CONTROL OF MACROPHAGE FOAM CELL FORMATION Christopher K. Glass USA 11:55 FARNESOID X RECEPTOR ACTIVATION INDUCES CHOLESTERYL ESTER TRANSFER PROTEIN EXPRESSION IN HUMANS AND TRANSGENIC MICE T. Gautier, W. de Haan, D. Ye, M.J. Bahr, T. Claudel, T.J.C. Van Berkel, J. Grober, L. Lagrost, F. Kuipers, M. Van Eck, P.C.N. Rensen, Uwe J.F. Tietge The Netherlands 12:05 PPARA ACTIVATION DIFFERENTLY AFFECTS MICROPARTICLE CONTENT IN ATHEROSCLEROTIC LESIONS AND LIVER OF A MOUSE MODEL OF ATHEROSCLEROSIS AND NASH Morgane Baron, A.S. Leroyer, Z. Majd, F. Lalloyer, E. Vallez, K. Bantubungi, G. Chinetti-Gbaguidi, P. Delerive, C.M. Boulanger, B. Staels, A. Tailleux France 12:15 C/EBPΒ CONTROLS EXERCISE-INDUCED CARDIAC GROWTH AND PROTECTS AGAINST PATHOLOGICAL CARDIAC REMODELING Pontus Boström, N. Mann, J. Wu, P.A. Quintero, E.R. Plovie, D.R. Panáková, R.K. Gupta, C.K. Xiao, C.A. MacRae, A. Rosenzweig, B.M. Spiegelman USA 12:25 DISCUSSION From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Chairpersons: 35 eas2011_final.indd 89 6/9/11 10:07 PM 36 eas2011_final.indd 90 6/9/11 10:07 PM FINAL PROGRAMME POSTER PRESENTATIONS AND MODERATED POSTER SESSIONS XCI June 26-29, 2011 XCII 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS Poster No 1.01 DUAL METABOLIC DEFECTS ARE REQUIRED TO PRODUCE HYPERTRIGLYCERIDEMIA IN OBESE SUBJECTS Martin Adiels, M.R. Taskinen, J. Westerbacka, S. Söderlund, J. Kahri, N. Lundbom, J. Lundbom, A. Hakkarainen, S.O. Olofsson, M. Ohro-Melander, J. Borén Sweden 1.02 DO INTAKES OF FATTY ACIDS MODIFY THE ASSOCIATION BETWEEN GENETIC VARIATION IN FADS-LOCUS AND LIPID CONCENTRATION? Sophie Hellstrand, E. Sonestedt, U. Ericson, B. Gullberg, E. Wirfält, M. Svensson, M. Orho-Melander Sweden 1.03 EFFECT OF ONE YEAR TREATMENT WITH INSULIN AND ORAL GLUCOSELOWERING AGENTS ON LIPID LEVELS IN NON-OBESE PATIENTS WITH TYPE 2DIABETES Søren Søgaard Lund, L. Tarnow, B. Nielsen, B. Hansen, M. Frandsen, O. Pedersen, H.H. Parving, A. Vaag Denmark 1.04 REGULATION OF BILE ACID AND CHOLESTEROL METABOLISM BY ENDOGENOUS THYROID HORMONE IN HUMANS Ylva Bonde, B. Angelin, M. Rudling Sweden 1.05 NONFASTING BLOOD CONCENTRATION OF LIPOPROTEIN SUBFRACTIONS AND RISK OF CORONARY HEART DISEASE IN A SWEDISH NESTED CASECONTROL STUDY Emily Sonestedt, S. Chiu, O. Melander, M. Orho-Melander, R.M. Krauss Sweden 1.06 MARINE N-3 FATTY ACIDS IN SERUM PHOSPHOLIPIDS AS BIOMARKERS OF INTAKE INFLUENCE LDL HETEROGENEITY IN SUBJECTS WITH FAMILIAL LIPOPROTEIN DISORDERS Aleix Sala-Vila, M. Cofán, R. Mateo-Gallego, A. Cenarro, F. Civeira, E. Ros Spain 37 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.07 CHANGES IN HUMAN LIPOPROTEIN COMPOSITION IN PATIENTS WITH ACUTE CORONARY SYNDROME Stefan Ljunggren, H. Karlsson, H. Mörtstedt, L. Hellström, J. Perk, C. Besler, U. Landmesser, A. von Eckardstein, M. Lindahl Sweden 1.08 THE MOLECULAR BASIS OF AUTOSOMAL DOMINANT HYPERCHOLESTEROLEMIA: ASSESSMENT IN A LARGE COHORT OF HYPERCHOLESTEROLEMIC CHILDREN A. van der Graaf, H.J. Avis, D.M. Kusters, M.N. Vissers, B.A. Hutten, J.C. Defesche, R. Huijgen, S.W. Fouchier, F.A. Wijburg, J.J. Kastelein, Albert Wiegman The Netherlands 1.09 LOW LIPOPROTEIN(a) CONCENTRATION IS ASSOCIATED WITH SHORTER SURVIVAL: A POPULATION-BASED COHORT STUDY (THE JMS COHORT STUDY) Motoji Sawabe, N. Tanaka, M.N. Mieno, S. Ishikawa, K. Kayaba, K. Nakahara, S. Matsushita, The JMS Cohort Study Group Japan 1.10 THE FUNCTION OF APOA5 IN THE METABOLISM OF TRIGLYCERIDE-RICH LIPOPROTEINS (TRL) PARTIALLY DEPENDS ON LRP1 Karoline Brügelmann, A. Bartelt, J. Heeren, M. Merkel Germany 1.11 HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA IN NORWAY, SWEDEN, DENMARK AND FINLAND- SUBSTANTIAL VARIATION IN FREQUENCY OF THE DIAGNOSIS A Græsdal, M.P. Bogsrud, Y. Stålstrøm, K. Retterstøl, G. Langslet, L. Ose Norway 1.12 A VARIANT NEAR THE MELANOCORTIN-4 RECEPTOR (MC4R) GENE REGULATE POSTPRANDIAL LIPID METABOLISM IN A HEALTHY CAUCASIAN POPULATION Pablo Perez-Martinez, J. Delgado-Lista, A. Garcia-Rios, N. Delgado-Casado, C. Marin, P. Gomez-Luna, F. Perez-Jimenez, J. Lopez-Miranda Spain 1.13 MOLECULAR DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLEMIA: THE UTILITY OF A COUNTRY SPECIFIC PROTOCOL Maria D'Agostino, M. Romano, M.D. Di Taranto, G. Marotta, M. Gentile, A. Iannuzzi, P. Rubba, G. Fortunato Italy 38 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.14 INSULIN RESISTANCE IS ASSOCIATED WITH THE METABOLIC SYNDROME BUT NOT WITH PERIPHERAL ARTERIAL DISEASE Alexander Vonbank, C.H. Saely, P. Rein, C. Boehnel, S. Greber, H. Drexel Austria, Liechtenstein 1.15 APOLIPOPROTEIN PROFILES IN ATHEROSCLEROTIC DISEASE Marilena Formato, A.J. Lepedda, E. Zinellu, A. Cigliano, F. Piredda, P.P. Bacciu, A. Guarino, R. Spirito Italy 1.16 SERUM INTESTINAL APOB-48 IS INCREASED IN PATIENTS WITH SEVERE HYPERTRIGLYCERIDEMIA A. Abed, P. Giral, R. Bittar, D. Bonnefont-Rousselot, Jean-Marc Lacorte France 1.17 EFFICACY OF EZETIMIBE/STATINS AND STATIN MONOTHERAPY AND FACTORS ASSOCIATED WITH TREATMENT RESPONSE: POOLED ANALYSIS OF >21,000 SUBJECTS FROM 27 TRIALS Peter P Toth, D. Morrone, W. Weintraub, M.E. Hanson, R.S. Lowe, J. Lin, A. Shah, A.M. Tershakovec USA 1.18 METABOLIC BENEFITS OF ECCENTRIC ENDURANCE EXERCISE IN OVERWEIGHT AND OBESE INDIVIDUALS P. Rein, C.H. Saely, A. Vonbank, S. Aczel, C. Boehnel, V. Kiene, Veronika Drexel, T. Bochdansky, H. Drexel Austria, Liechtenstein 1.19 EFFECTS OF EPA ON THE RISK OF CORONARY ARTERY DISEASE IN HYPERCHOLESTEROLEMIC PATIENTS IN RELATED WITH NONATTAINMENT THE LIPID MANAGEMENT GOALS FOR LDL-C OR NON HDL-C: SUB-ANALYSIS OF THE JELIS Jun Sasaki, M. Yokoyama, M. Matsuzaki, Y. Saito, H. Origasa, Y. Ishikawa, S. Oikawa, H. Itakura, H. Hishida, T. Kita, A. Kitabatake, N. Nakaya, T. Sakata, K. Shimada, K. Shirato, Y. Matsuzawa Japan 1.20 INFLUENCE OF APOE GENOTYPE IN THE PHENOTYPE OF CLINICAL DIAGNOSED PORTUGUESE FH PATIENTS Ana Margarida Medeiros, T. Santos, A.C. Alves, M. Bourbon, on behalf of the Investigators of the Portuguese FH Study Portugal 39 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.21 COMPARISON OF THE EFFECTS OF SIMVASTATIN VERSUS ROSUVASTATIN VERSUS SIMVASTATIN/EZETIMIBE ON PARAMETERS OF CARBOHYDRATE METABOLISM E. Moutzouri, E. Liberopoulos, M. Kostapanos, H. Milionis, Moses Elisaf Greece 1.22 CHANGES IN LDL-C LEVELS AND GOAL ATTAINMENT ASSOCIATED WITH ADDING EZETIMIBE ONTO SIMVASTATIN, ATORVASTATIN AND ROSUVASTATIN COMPARED WITH TITRATING STATINS J.M. Foody, Peter P Toth, S. Sajjan, D.R. Ramey, D.R. Neff, A.M. Tershakovec, H. Hu, J.E. Tomassini, K. Tunceli USA 1.23 TEMPORAL RESPONSES OF CHOLESTYRAMINE TREATMENT ON FGF19 LEVELS, BILE ACID AND CHOLESTEROL SYNTHESIS, SERUM TRIGLYCERIDES AND BILE ACID LEVELS Beatrice Sjöberg, S. Straniero, B. Angelin, M. Rudling Sweden 1.24 COMBINATION EZETIMIBE/SIMVASTATIN + EXTENDED-RELEASE NIACIN THERAPY IMPROVES ATTAINMENT OF RECOMMENDED LDL-C, NON-HDL-C AND APOB LEVELS IN HYPERLIPIDEMIC PATIENTS Sergio Fazio, J.R. Guyton, J. Lin, J.E. Tomassini, A. Shah, A.M. Tershakovec USA 1.25 SERUM LEVELS OF VASPIN AND CARDIOVASCULAR RISK FACTORS IN MORBID OBESE PATIENTS Atefeh Golpaie, Z. Karbaschian, N. Tajik, M.J. Hosseinzadeh-Attar Iran 1.26 PRO-ATHEROGENIC POSTPRANDIAL PROFILE: MEAL INDUCED CHANGES OF LIPOPROTEIN SUB-FRACTIONS AND INFLAMMATION MARKERS IN OBESE BOYS Alberto Zambon, L. Pinelli, M.G. Surano, M. Carlon, S. Cordioli, S. Gasperotti, D. Vianello, C. Maffeis Italy 1.27 RISK FACTORS FOR NON-ALCOHOLIC FATTY LIVER DISEASE IN RUSSIAN FEDERATION IN NATIONAL-WIDE DIREG-L-01903 STUDY Oxana M Drapkina, V.T. Ivashkin Russia 1.28 THE LIVER SIEVE IN CHOLESTEROL METABOLISM INFLUENCES BOTH LIFESTYLE AND FAMILIAL ATHEROSCLEROSIS Robin Fraser, B.R. Dobbs, V.C. Cogger, D.G. Le Couteur New Zealand 40 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.29 TOTAL CHOLESTEROL TO APOLIPOPROTEIN B100 RATIO IN ADVANCED STABLE ANGINA PATIENTS TREATED WITH STATINS Pawel Burchardt, B. Zuchowski, A. Palasz, J. Zurawski, H. Wysocki Poland 1.30 STUDY ON EFFECT OF COMBINING ORLISTATE - EZETIMIDE ON LIPIDEMIC PROFILE ON OBESE PATIENTS Stefanos Patiakas, C. Charalampous Greece 1.31 EXTENDED RELEASE NIACIN/LAROPIPRANT LOWERS ATHEROGENIC LIPIDS ACROSS PATIENT SUBGROUPS C.M. Ballantyne, H.E. Bays, A.K. Shah, C. Sisk, Q. Dong, Darbie Maccubbin USA 1.32 LIPID PARAMETERS IN ACUTE CORONARY SYNDROMES VERSUS STABLE CORONARY ARTERY DISEASE Alexander Vonbank, C.H. Saely, P. Rein, C. Boehnel, V. Jankovic, J. Breuss, H. Drexel Austria, Liechtenstein 1.33 OXIDATIVE STRESS AND ANTIOXIDANT PARAMETERS IN PATIENTS WITH HYPERLIPIDEMIA Odkhuu Enkhtaivan, M. Malchinkhuu, L. Tserenkhuu Mongolia 1.34 ROLE OF BLOOD CHOLESTEROL TRANSPORT SYSTEM DISTURBANCES IN ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS (RA) Tatiana Popkova, D. Novikova, A. Novikov, E. Alexandrova, E. Nasonov Russia 1.35 ASSOCIATIONS OF APOE POLYMORPHISMS WITH BASELINE LIPIDS AND RESPONSE TO ROSUVASTATIN VARY IN CHINESE PATIENTS WITH AND WITHOUT FAMILIAL HYPERCHOLESTEROLAEMIA Miao Hu, V.W.L. Mak, E.W.M. Poon, B. Tomlinson Hong Kong S.A.R. 1.36 MECHANISM OF HYPERCHOLESTEROLEMIA IN PHHC RAT Miluše Zimolová, M. Schmiedtová, M. Heczková, R. Poledne, M. Jirsa, J. Kovář Czech Republic 1.37 COMPARATIVE EFFECT OF APHERESIS VS ATORVASTATIN/APHERESIS ON MARKERS OF INFLAMMATION IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA Mariarita Puntoni, F. Sbrana, F. Bigazzi, F. Minichilli, T. Sampietro Italy 41 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.38 POLIDISTRECTUAL VASCULAR INVOLVEMENT IN FAMILIAL HYPERCHILOMICRONEMIA Francesco Sbrana, M. Puntoni, F. Bigazzi, M. Margelli, C. Petersen, R. Bonini, T. Sampietro Italy 1.39 AVERAGE LIPID PARAMETERS IN THREE CENTERS OF CENTRAL AND EASTERN EUROPE: HAPIEE PROJECT Ksenia Makarenkova, S. Malyutina, G. Simonova, M. Bobak, Y. Nikitin, HAPIEE Group Russia 1.40 SMOKING INTENSITY MAY HINDER THE BENEFICIAL EFFECT OF STATIN THERAPY ON CIRCULTING OXIDIZED LOW-DENSITY LIPOPROTEIN LEVELS AND CAROTID AHTEROMATOUS STENOSIS Sofoklis Kougialis, E. Skopelitis, D. Levisianou, A. Zervou, T. Gialernios, N. Kosmas, E. Mouka, A. Galanopoulou, H. Mpilinis, A. Polydorou Greece 1.41 OBESITY AND METABOLIC SYNDROME Pavol Hlubik, H. Stritecka, J. Hlubik Czech Republic 1.42 HOW IS LIPID PROFILE ALTERED AFTER CARDIAC SURGERY Renato Alves, D. Aguiar, B. Andrade, K. Nakiri Brazil 1.43 STUDY ON CHANGE OF VALUES OF CHOLESTEROL AND TRIGLYCERIDES IN HYPERLIPIDEMIC PATIENTS IN RELATION TO THE SEASON OF THE YEAR S.S. Patiakas, Charalampos C. Charalampous Greece 1.44 ATHEROGENIC INDEX OF PLASMA [=(LOG10TRIGLYCERIDES/HDL-CHOLESTEROL)] AND CRP DURING CHRONIC HEMODIALYSIS TREATMENT Vladimir Soska, D. Sobotova Czech Republic 1.45 LIPIDS AND INFLAMMATORY MARKERS IN THE ACUTE PHASE RESPONSE OF MYOCARDIAL INFARCTION Luis Bronze, J. Azevedo, M.J. Relvas, M.L. Andrade, I. Arroja, M. Mendes, M. Seabra, G. Morais, A. Aleixo Portugal 42 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.46 DISORDERS OF LIPIDS METABOLISM IN PATIENTS WITH RHEUMATOID ARTHRITIS Iryna Klymas Ukraine 1.47 ACUTE EXERCISE INCREASES REMNANT LIPOPROTEIN CHOLESTEROL IN TYPE 1 DIABETES (T1DM) Marta Gonzalez, L. Brugnara, S. Murillo, M. Guardiola, A. Novials, J. Ribalta Spain 1.48 EFFECT OF STANDARD COMBINATION OF VALSARTAN WITH EITHER AMLODIPINE OR HYDROCHLOROTHIAZIDE ON LDL SUBFRACTION PROFILE IN PATIENTS WITH HYPERTENSION Leonidas G. Christogiannis, M.S. Kostapanos, H.J. Milionis, Z. Mitrogianni, E. Moutzouri, A.D. Tselepis, M.S. Elisaf Greece WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE 1.49 ARAP2-INDUCED CHANGES IN SPHINGOLIPID BIOSYNTHESIS PROMOTE LIPID DROPLET FORMATION BY INCREASING GLUT1 LEVELS IN THE PLASMA MEMBRANE Lu Li, R. Mobini, E. Lu, M. Rutberg, M. Ståhlman, L. Håversen, B. Liu, T. Larsson, R. Perkins, L. Andersson, K. Koistinen, K. Ekroos, J. Borén, S.O. Olofsson Sweden 1.50 A NOVEL THREE-PROTEIN COMPLEX REGULATES IN VITRO VTV-GOLGI FUSION Shadab A Siddiqi, E. Nafi-Valencia, S. Siddiqi, A. Rahim USA 1.51 MURINE BONE MARROW-DERIVED MACROPHAGES DIFFERENTIATED WITH GM-CSF BECOME FOAM CELLS BY PI 3-KINASE GAMMA-DEPENDENT FLUIDPHASE PINOCYTOSIS OF NATIVE LDL J.J. Anzinger, J. Chang, Q. Xu, T. Bohnacker, M.P. Wymann, Howard S. Kruth USA 1.52 LIPID DROPLETS: STRUCTURE, PROTEIN ORGANIZATION AND BIOGENESIS Horst Robenek, N.J. Severs, G. Weissen-Plenz, A. Ruebel, I. Buers Germany 43 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE (contd.) Poster No 1.53 TRIACYLGLYCEROL-RICH LIPOPROTEINS INFLUENCE ON THE INACTIVATION OF LIPOPROTEIN LIPASE BY ANGPTL 3 AND ANGPTL 4 Stefan Nilsson, M. Larsson, E. Worrsjö, A. Lookene1, V. Suokonina, E. Makoveichuk, J. Heeren, G. Olivecrona Sweden 1.54 THE GAIN OF FUNCTION D374Y-PCSK9 MUTANT CAN BE FUNCTIONALLY INHIBITED IN VITRO BY AN EGF-A PEPTIDE Angelo B. Cefalu', D. Noto, E. Pinotti, V. Valenti, P. Tarugi, M.R. Averna Italy 1.55 PCSK9 IN FAMILIAL HYPERCHOLESTEROLEMIA (FH) Gilles Lambert, K.A. Rye, J. Burnett, P. Barter, D. Marais France, Australia 1.56 RIP2 LINKS IMMUNE SIGNALING AND SUBENDOTHELIAL LIPID ACCUMULATION BY REGULATING TLR4-DEPENDENT LIPID UPTAKE IN MACROPHAGES Malin Levin, P. Jirholt, M. Johansson, A. Wramstedt, A. Lundberg, M. Ståhlman, P. Fogelstrand, M. Brisslert, Z.Q. Yan, G. Hansson, H. Björkbacka, S.-O. Olofsson, J. Borén Sweden WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) 1.57 APOLIPOPROTEINS A1 AND B AND THE RISK OF CARDIOVASCULAR RECURRENCES IN ISCHEMIC STROKE PATIENTS Simone Vidale, A. Sampietro, L. Tancredi, M. Arnaboldi Italy 1.58 LDL SIZE DETERMINANTS DURING ANTIRETROVIRAL THERAPY INCLUDING PROTEASE INHIBITORS IN HIV-1 INFECTED PATIENTS Randa Bittar France 44 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.59 CARDIOVASCULAR RISK IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH OR WITHOUT METABOLIC SYNDROME Jesus Millan, C. Garcia Calzado, C. Recarte Spain 1.60 CONSTITUTIVE INHIBITION OF PLASMA CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) BY APOLIPOPROTEIN C1 IN NORMOLIPIDEMIC, BUT NOT IN HYPERLIPIDEMIC PATIENTS WITH CORONARY ARTERY DISEASE. CONSEQUENCES ON PLASMA CHOLESTEROL DISTRIBU X. Pillois, T. Gautier, J.-P. Pais de Barros, A. Jeannin, J. Bonnet, Laurent Lagrost France WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE (contd.) 1.61 CHOLESTEROL LOWERING DRUGS INHIBIT THE ABSORPTION OF CARDIOPROTECTIVE OMEGA-3 FATTY ACIDS David Blackwood, A. Al-Busaidi, R. La Vallee, D. Jassal, G. Pierce Canada 1.62 GROUP V SECRETORY PHOSPHOLIPASE A2 PROTECTS AGAINST CARDIAC FIBROSIS - A POSSIBLE TARGET FOR HEART FAILURE TREATMENT Boris Boyanovsky USA 1.63 LACK OF INVARIANT NATURAL KILLER T CELLS DOES NOT AFFECT ADIPOSE TISSUE INFLAMMATION AND METABOLIC DYSREGULATION IN DIET-INDUCED OBESE MICE Daniela Strodthoff, H.E. Agardh, A.M. Lundberg, G. Paulsson-Berne, G.K. Hansson, N. Gerdes Sweden 1.64 LIPID DROPLETS IN HUMAN MACROPHAGES RECRUIT CYTOSOLIC PHOSPHOLIPASE A2 AND PROMOTE SECRETION OF INFLAMMATORY MEDIATORS P. Boström, Y. Wickström, Lillemor Mattsson Hultén, R. Perkins, M. Ståhlman, O. Wiklund, S.O. Olofsson, J. Borén Sweden 1.65 REDUCED SYNTAXIN-5 IN SKELETAL MUSCLE OF PATIENTS WITH TYPE 2 DIABETES. A LINK BETWEEN LIPID STORAGE AND INSULIN RESISTANCE Linda Andersson, S. Myhre, P. Bostrom, M. Ståhlman, B. Vind, L. Håversen, J. Borén, K. Hojlund, S.O. Olofsson Sweden 45 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE (contd.) Poster No 1.66 SALVIANOLIC ACID B CAN INHIBIT MACROPHAGE UPTAKE OF MODIFIED-LDL BY DIRECTLY BINDING TO TYPE B SCAVENGER RECEPTOR CD36 Li Wang, Y. Bao, Y. Xu, Y. Yang, L. Wang, S. Si, S. Cho, B. Hong China 1.67 INHIBITION OF ENDOPLASMIC RETICULUM STRESS RECOVERS ABCA-1 EXPRESSION AND APO A-I-MEDIATED CHOLESTEROL EFFLUX IN MACROPHAGES SUBMITTED TO GLYCOXIDATION Gabriela Castilho, L.S. Okuda, E.R. Nakandakare, C.X.C. Santos, F.R.M. Laurindo, M. Passarelli Brazil 1.68 TG INTERACTING FACTOR ACTS AS A TRANSCRIPTIONAL REPRESSOR OF ACAT2 IN HUMAN Camilla Pramfalk, M. Eriksson, P. Parini Sweden 1.69 DIETARY SUGAR INCREASES LIVER CHOLESTEROL PARTLY THROUGH REDUCED BILIARY SECRETION OF CHOLESTEROL AND BY REDUCED SYNTHESIS OF BILE ACIDS Johanna Lundberg, L. Persson, C. Gälman, B. Angelin, M. Rudling Sweden 1.70 INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INCREASES LIPID ACCUMULATION IN MACROPHAGES Tuva Boerresdatter Dahl, T. Ranheim, S. Holm, P. Aukrust, B. Halvorsen Norway 1.71 ANTI-ARRHYTHMIC EFFECTS OF VERY LOW DENSITY LIPOPROTEINS Yangzhen Shao, A. Mijatovic, S. Gizurarson, T. Råmunddal, J. Borén, E. Omerovic Sweden 1.72 FATTY ACID BINDING PROTEIN 4 INDUCES ENDOTHELIAL DYSFUNCTION THROUGHT INSULIN-SIGNALING PATHWAY IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS Gemma Aragonès, J. Girona, I. Lázaro, A. Cabré, L. Masana Spain 46 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.73 RELATIONSHIPS BETWEEN HSCRP REDUTION AND LDL-C, NON-HDL-C, APOB AND HDL-C IN HYPERLIPIDEMIC PATIENTS TREATED WITH EZETIMIBE/SIMVASTATIN + EXTENDED-RELEASE NIACIN W Virgil Brown, S. Fazio, J.R. Guyton, Q. Dong, J.E. Tomassini, A. Shah, A.M. Tershakovec USA 1.74 COMPLETE SEQUENCING OF APOB GENE OF PATIENTS WITH CLINICAL DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLAEMIA Ana Catarina ALves, M. Bourbon Portugal 1.75 VARIABILITY OF DIURNAL TRIGLYCERIDE LEVELS IN MEN AND WOMEN Boudewijn Klop, A.J.H.H.M. van Oostrom, J.P.H. van Wijk, A. Alipour, E. Birnie, J.W.F. Elte, J.S. Cohn, M. Castro Cabezas The Netherlands 1.76 POST-PRANDIAL LIPIDEMIA IS REDUCED BY TREATMENT OF OBSTRUCTIVE SLEEP APNOEA: A RANDOMISED, PLACEBO CONTROLLED TRIAL OF CONTINUOUS POSITIVE AIRWAY PRESSURE David Richmond Sullivan, N. Lai, C. Phillips, R. Grunstein, B. Yee, P. Liu Australia 1.77 INFLUENCE OF THE GLUCOSE TOLERANCE TEST ON PRO-ATHEROGENIC MODIFICATION OF LDL AND ITS RELATION TO PARAOXONASE ACTIVITY Handrean Soran, V. Charlton-Menys, N. Younis, M. France, M. Bannerjee, K. Cruickshank, P. Durrington UK 1.78 SERUM LEVELS OF LIPIDS, OXIDATIVE STRESS AND HEPATIC HISTOLOGY IN OBESE PATIENTS UNDERGOING BARIATRIC SURGERY Osamah Amin Hussein, I. Shams, K. Abu Jabal, I. Dashkovsky, S. Szvalb, I. Waksman Israel 47 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.79 MILDER PHENOTYPE OF RELATIVES OF INDEX PATIENTS CAN MISDIAGNOSE FAMILIAL HYPERCHOLESTEROLEMIA Ana Margarida Medeiros, A.C. Alves, M. Bourbon, on behalf of the Investigators of the Portuguese FH Study Portugal 1.80 SEASONAL VARIATIONS IN TRANS-SIALIDASE ACTIVITY IN HUMAN BLOOD A.N. Orekhov, A.S. Feoktistov, E.A. Orekhova, V.A. Smutova, I.A. Sobenin, Alexey V. Pshezhetsky Canada 1.81 CHOLESTEROL METABOLISM IN PATIENTS WITH DIABETES MELLITUS TYPE 1 AND IMPACT OF WEIGHT REDUCTION Jana Lesná, V. Bláha, A. Tichá, R. Hyńpler, F. Musil, L. Sobotka, A. Ńmahelová Czech Republic 1.82 EZITIMIBE ALONE AND IN COMBINATION LOWERS CONCENTRATIONS OF SMALL, DENSE LOW DENSITY LIPOPROTEINS IN TYPE 2 DIABETES MELLITUS Karl Winkler, S. Jacob, T. Schewe, G. Putz, M.M. Hoffmann, T. Konrad Germany 1.83 LIPOPROTEIN(A) AND FAMILY HISTORY OF CARDIOVASCULAR DISEASE IN CHILDREN Ornella Guardamagna, F. Abello, P. Assandro, G. Anfossi, M. Pirro Italy 1.84 EZETIMIBE/SIMVASTATIN 10/40MG VERSUS ATORVASTATIN 40MG IN HIGH CARDIOVASCULAR RISK PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA: A RANDOMIZED, DOUBLE-BLIND, ACTIVE-CONTROLLED, MULTICENTER STUDY Fernando Civeira, A.G. Dan, P.L.K. Hing, M.E. Hanson, R. Massaad, C. Milardo, J. Triscari Spain 1.85 EZETIMIBE MONO-THERAPY AMELIORATES VASCULAR FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA THROUGH DECREASING OXIDATIVE STRESS Hirotsugu Kurobe, K.I. Aihara, Y. Hirata, T. Motoki, M. Sugano, T. Kanbara, T. Nakayama, T. Kitaichi, M. Akaike, M. Sata, T. Matsumoto, T. Kitagawa Japan 1.86 IMPROVED PLASMA LIPID PROFILE AND REDUCTION IN HEPATIC STEATOSIS WITH RIMONABANT THERAPY IN MORBIDLY OBESE PATIENTS Anthony S Wierzbicki, S. Pendleton, Z. MacMahon, A. Dar, M.A. Crook, A.J. Botha UK 48 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.87 UPDATE OF THE BIOCHEMICAL AND MOLECULAR RESULTS OF PORTUGUESE PATIENTS WITH FAMILIAL COMBINED HYPERLIPIDAEMIA T. Santos, Q. Rato, I.M. Gaspar, M.T. Rico, J.M. Silva, Mafalda Bourbon Portugal 1.88 THE EFFECTS OF COMBINING ROSUVASTATIN WITH SARTANS OF DIFFERENT PPARΓ ACTIVATING CAPACITY ON LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 C.V. Rizos, E.N. Liberopoulos, C.C. Tellis, M. Florentin, Moses S. Elisaf, A.D. Tselepis Greece 1.89 THE PRESENCE OF REMNANT LIPOPROTEINS IN THE FASTING PLASMA WITH TG LEVELS LESS THAN 150 MG/DL Katsuyuki Nakajima, T. Nakano, Y. Tokita, T. Nagamine, S. Yatsuzuka, Y. Shimomura, A. Tanaka Japan 1.90 HYPERLIPIDEMIA AND OXIDATIVE STRESS ARE THE MAIN DETERMINANTS OF INTIMA-MEDIA THICKNESS IN CHILDREN WITH CHRONIC KIDNEY DISEASE Slavica Spasic, J. Kotur-Stevuljevic, A. Peco-Antic, M. Kostic, D. Vasic, A. Stefanovic, A. Vujovic, Z. Jelic-Ivanovic, V. Spasojevic-Kalimanovska, D. Kornic Serbia 1.91 IN SILICO MODELLING OF HUMAN LIPOPROTEIN METABOLISM Martin Jansen, K. Winkler, G. Pütz, P. Pfaffelhuber Germany 1.92 ATORVASTATIN INCREASES CHOLESTEROL LEVELS IN APOE/LDLR-DEFICIENT MICE Martina Slanarova, E. Brcakova, L. Vecerova, Z. Strasky, J. Rathouska, R. Hyspler, A. Ticha, P. Nachtigal Czech Republic 1.93 DETERMINATION OF SDLDL PARTICLES IN PATIENTS WITH FAMILIAL HYERCHOLESTEROLAEMIA AND FAMILIAL COMBINED HYPERLIPIDAEMIA A. Gomes, T. Santos, Mafalda Bourbon Portugal 1.94 ACUTE STIMULATION OF ENDOGENOUS ESTROGEN IN WOMEN ALTERS CHOLESTEROL METABOLISM AND REDUCES PCSK9 AND LDL CHOLESTEROL LEVELS Lena Persson, P. Henriksson, E. Westerlund, O. Hovatta, B. Angelin, M. Rudling Sweden 49 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: METABOLISM OF ATHEROGENIC LIPOPROTEINS AND THEIR ROLE IN ATHEROSCLEROSIS (contd.) Poster No 1.95 TARGET LIPID LEVELS AND RESERVES IN HYPOLIPIDEMIC THERAPY IN THE PATIENTS AT VERY HIGH RISK OF CARDIOVASCULAR EVENTS Jozef Petrus, F. Málek, J. Dvořák, V. Skalníková, P. Neužil Czech Republic 1.96 OXIDIZED-LDL AND APO B48 IN DIABETIC KIDNEY DISEASE Nicola Fanton, T. Moreno, M.J. Alférez, M. Jiménez, I. Coca, D. Vianello, A. Zambon, P. ValdivielsoItaly Italy WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE (contd.) 1.97 REDUCED ATHEROSCLEROTIC PLAQUE FORMATION IN APOE-/- MICE LACKING PERILIPIN Prakash Krishnamurti Doddapattar, E. Aflaki, B. Radovic, N. Rathke, R.B. Gruenberger, D. Kratky Austria 1.98 DYNASORE, A DYNAMIN GTPASE INHIBITOR, BLOCKS LATE ENDOSOMAL/LYSOSOMAL CHOLESTEROL TRAFFICKING IN HUMAN MACROPHAGES Emmanuelle Girard, J.-L. Paul, P. Beaune, C. Lamaze, B. Védie France 1.99 CHOLESTEROL LOADING OF HUMAN MACROPHAGES REDUCES GROWTH FACTOR-INDUCED HETEROGENEITY OF GENE EXPRESSION INVOLVED IN FOAM CELL FORMATION Jani Lappalainen, N. Yeung, M. Jauhiainen, P.T. Kovanen, M. Lee-Rueckert Finland 1.100 LOW DENSITY LIPOPROTEIN ENHANCES C-REACTIVE PROTEIN-MEDIATED FCγ RECEPTOR SIGNAL TRANSDUCTION IN MACROPHAGES BUT NOT IN MONOCYTES Kefei Li, M. Radermacher, M. Kächele, C. Röcker, A. Pott, D. Manolov, W. Ito, U. Nienhaus, J. Torzewski, O. Zimmermann, J. Wiehe, M. Bienek-Ziolkowski, H. Ruland, K. Vogt Germany, China 50 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE (contd.) Poster No 1.101 IMPACT OF OMEGA 3 AND OMEGA 6 FATTY ACIDS MEMBRANE INCORPORATION ON CHOLESTEROL EFFLUX FROM CULTURED RAT CARDIOMYOCYTES Natalie Fournier, A. Reboulleau, V. Robert, B. Vedie, J.L. Paul , A. Grynberg France 1.102 NEW LMF1 VARIANTS IDENTIFIED IN HYPERTRIGLYCERIDEMIC PATIENTS Isabel De Castro-Orós, E. Ros, F. Civeira, M. Pocoví Spain 1.103 REGULATION OF LIVER AND ADIPOSE TISSUE LIPOGENESIS IN HUMAN OBESITY Joerg Heeren, M. Vossen, T. Scherer, L. Eissing, U. Knippschield, K. Toedter, C. Buettner, A. Wolf, L. Scheja Germany 1.104 SERUM LEVELS OF ANGIOPOIETIN-LIKE PROTEIN 4 (ANGPTL4) ARE INVERSELY CORRELATED WITH OBESITY IN HEALTHY YOUNG ADULT TWINS Marius Robert Robciuc, J. Naukkarinen, H. Tyynismaa, T. Raivio, A. Ortega-Alonso, A. Suomalainen, J. Kaprio, A. Rissanen, M. Jauhiainen, C. Ehnholm, K. Pietiläinen Finland 1.105 THE REDUCTION IN HDL RECEPTOR LEVELS IN MACROPHAGES IS RELATED TO ROS GENERATION INDUCED BY ADVANCED GLYCATED ALBUMIN Raphael Souza Pintio, B.A. Paim, G. Castilho, E.R. Nakandakare, A.E. Vercesi, M. Passarelli Brazil 1.106 AGE-ALBUMIN INDUCES INTRACELLULAR LIPID ACCUMULATION BY MODIFYING THE EXPRESSION OF GENES INVOLVED IN MACROPHAGE REVERSE CHOLESTEROL TRANSPORT AND CHOLESTEROL HOMEOSTASIS A. Machado-Lima, R.T. Iborra, R.S. Pinto, C.H. Sartori, E.R. Oliveira, J.T. Stefano, E.R. Nakandakare, D. Giannella-Neto, M.L. Corrêa-Giannella, Marisa Passarelli Brazil 1.107 INCREASED EXPRESSION OF LDLR AND ACCUMULATION OF CHOLESTEROL ESTERS IN RISK AND INFARCT AREA OF PIG HEARTS AFTER MYOCARDIAL INFARCTION L. Karlsson, Christina Olsson, M. Ståhlman, T. Larsson, J. Perman, L. Grip, J. Borén, S.O. Olofsson Sweden 51 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE (contd.) Poster No 1.108 EFFECTS OF THE COMBINATION OF SIMVASTATIN AND EZETIMIBE IN CHYLOMICRON KINETICS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE Otavio Celeste Mangili, R.D. dos Santos, R.C. Maranhão, A.C.M. Gagliardi, L.C. Mangili Brazil 1.109 PHOSPHOLIPIDOSIS IN STRESSED BY PRESENCE OF TNFA AND FATTY ACIDS (MIMICKING METABOLIC SYNDROMECONDITION) ENDOTHELIAL CELLS Beata Kiec-Wilk, U. Czech, A. Knapp, M. Awsiuk, J. Goralska, A. Sliwa, A. Gruca, H. Robenek, G. Schmitz, A. Dembinska-Kiec Poland 1.110 PANCREATITIS DUE TO MASSIVE HYPERTRIGLYCERIDAEMIA IN ALSTRÖM`S SYNDROM - A CASE REPORT Niels Gauer, E. Giannakidou-Jordan, E. Steinhagen-Thiessen, U. Kassner Germany 1.111 ADIPOSE TISSUE GENE EXPRESSION OF FACTORS RELATED TO LIPID PROCESSING IN OBESITY M. Clemente-Postigo, F.J. Tinahones, Fernando Cardona Spain 1.112 OLD MYTHS AND NEW INSIGHTS: INTERACTION OF LDL-SUBCLASSES WITH HUMAN FIBROBLASTS Gerhard Putz, K. Winkler Germany 1.113 ELEVATED APOLIPOPROTEIN C-III CONTENT IN RECONSTITUTED LOW-DENSITY LIPOPROTEIN EXACERBATED CELLULAR ATHEROSCLEROSIS AND NONENZYMATIC PROTEIN GLYCATION. Seong-Min Kim, K.H. Cho Republic of Korea 1.114 ADIPOPHILIN ACCUMULATED CELLULAR LIPID THROUGH ERK1/2-PPARΓ PATHWAY IN RAW264.7 CELLS Zhonghua Yuan, Q. Liu, Z. Liu, C. Tang, Z. Wang, G. Yi, Y. Yang China 1.115 WHAT CAN TEACH US CORRELATIONS BETWEEN MRNAS CONTENTS IN MACROPHAGES FROM MEN AND WOMEN? A. Smirnov, T.A. Shchelkunova, I.A. Morozov, P.M. Rubtsov, I.A. Sobenin, Alexander N. Orekhov, I.V. Andrianova, E.G. Rudymov Russia 52 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: CELLULAR LIPID METABOLISM, FROM UPTAKE TO STORAGE (contd.) Poster No 1.116 ESTIMATION OF THE CONTRIBUTION OF MACROPHAGE MRNAS TO THE OBSERVED CHANGES IN MRNAS LEVELS IN THE VESSEL INTIMA AT ATHEROGENESIS A. Smirnov, T.A. Shchelkunova, I.A. Morozov, P.M. Rubtsov, I.A. Sobenin, Alexander N. Orekhov, I.V. Andrianova Russia 1.117 ENHANCED BIOSYNTHESIS OF GANGLIOSIDE GM3 IN ATHEROSCLEROSIS Nelya N Samovilova, E.V. Gracheva, N.K. Golovanova, O. Kaliya, N.V. Prokazova Russia 1.118 POSSIBLE ROLE OF SPHINGOLIPIDS IN BETA-CAROTENE -INDUCED ENDOTHELIA PROANGIOGENIC ACTIVITY Anna Polus, B. Kiec-Wilk, M. Mikołajczyk, J. Hartwich, R. Goralczyk, A. Dembinska-Kiec Poland WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL 1.119 NOVEL ABCA1 MUTATIONS IN L PATIENTS WITH SEVERE HDL DEFICIENCY WITH OR WITHOUT CLASSIC MANIFESTATIONS OF TANGIER DISEASE Paolo Zanoni, T. Fasano, P.B. Deegan, A. Park, M.D. Feher, F. Gurakan, E. Favari, F. Bernini, S. Calandra Italy 1.120 SPHINGOSINE KINASE INHIBITION INDUCES BOTH PRO- AND ANTI-ATHEROGENIC EFFECTS IN LOW-DENSITY LIPOPROTEIN RECEPTOR-DEFICIENT MICE Sara Costa, F. Poti, M. Bot, V. Bergonzini, M. Galletti, L. Maynes, G. Varga, M. Simoni, J.R. Nofer Italy 1.121 MITOCHONDRIAL INHIBITORY FACTOR 1 (IF1) IS PRESENT IN HUMAN SERUM AND ITS LEVEL IS POSITIVELY ASSOCIATED TO HDL-C A. Genoux, V. Pons, M. Laffargue, G. Combes, J.B. Ruidavets, J. Ferrières, B. Perret, Laurent O Martinez France 1.122 HDL FUNCTION IS IMPAIRED IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION INDEPENDENT OF PLASMA HDL CHOLESTEROL LEVELS Wijtske Annema, H.M. Willemsen, R.A. Tio, U.J.F. Tietge The Netherlands 53 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.123 NIACIN, ATORVASTATIN AND FENOFIBRATE DECREASE PLASMA CETP BY REDUCTION OF THE HEPATIC MACROPHAGE CONTENT IN APOE*3-LEIDEN.CETP MICE Y. Wang, Z. Li, M. Hoekstra, V. Bieghs, R. Shiri-Sverdlov, T.J.C. Van Berkel, J.W.A. Smit, H.M.G. Princen, J.A. Romijn, L.M. Havekes, Patrick C.N. Rensen The Netherlands 1.124 PROTEOMIC ALTERATIONS OF HDL FROM HEMODIALYSIS PATIENTS ARE ASSOCIATED WITH IMPAIRED CHOLESTEROL EFFLUX CAPACITY Michael Holzer, R. Birner-Gruenberger, V. Binder, D. El-Gamal, G. Marsche Austria 1.125 PROTECTION OF HDL AGAINST SPHINGOMYELINASE-MODIFIED LDL AGGREGATION AT ACIDIC PH Su Duy Nguyen, K. Öörni, P.T. Kovanen Finland 1.126 THE INHIBITION OF HEPATIC ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE (ACAT) 2 POSITIVELY AFFECTS HDL METABOLISM AND FUNCTIONALITY IN MICE Matteo Pedrelli, P. Davoodpour, C. Degirolamo, M. Gomaraschi, L. Larsson, L.L. Rudel, L. Calabresi, J.Å. Gustafsson, K. Steffensen, M. Eriksson, P. Parini Sweden 1.127 ANTI-INFLAMMATORY EFFECTS OF A NOVEL INDUCER OF APOLIPOPROTEIN A-I SYNTHESIS: INSIGHTS FROM THE ASSERT STUDY Stephen J Nicholls, A. Gordon, J. Johansson, C.M. Ballantyne, J.J. Kastelein, N.C. Wong, M. Borgman, K. Wolski, S.E. Nissen USA 1.128 PROTEIN CARBAMYLATION RENDERS HIGH-DENSITY LIPOPROTEIN DYSFUNCTIONAL Gunther Marsche, M. Gauster, M. Holzer Austria 1.129 DIABETIC DYSLIPIDEMIA IS RESPONSIBLE FOR QUALITATIVE AND QUANTITATIVE CHANGES IN HDL LIPID COMPOSITION Marcus Ståhlman, A. Kontush, B. Fagerberg, K. Ekroos, J. Chapman, J. Borén Sweden 54 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.130 APOLIPOPROTEIN A-I STIMULATES BOTH APOLIPOPROTEIN E AND CHOLESTERYL ESTER TRANSFER PROTEIN SECRETION IN LIPID LOADED MACROPHAGES Loredan Stefan Niculescu, C.S. Stancu, M. Robciuc, A.V. Sima Romania 1.131 MAST CELL ACTIVATION IN VIVO IMPAIRS THE MACROPHAGE REVERSE CHOLESTEROL TRANSPORT PATHWAY IN THE MOUSE Reija Silvennoinen, M. Lee-Rueckert, N. Rotllan, I. Judstrom, F. Blanco-Vaca, M. Jauhiainen, J. Metso, J.C. Escola-Gil, P.T. Kovanen Finland 1.132 CELLULAR CHOLESTEROL EFFLUX CAPACITY AND ANTIOXIDATIVE ACTIVITY OF HDL SUBPOPULATIONS SHARE MAJOR COMPOSITIONAL AND STRUCTURAL DETERMINANTS: ARE COMMON MECHANISMS INVOLVED? Laurent Camont, M. Lhomme, S. Chantepie, F. Rached, R. Frigola, W. Le Goff, M.J. Chapman, A. Kontush France 1.133 AGE-ASSOCIATED DECREASE IN HDL AND PON-1 ANTI-INFLAMMATORY ACTIVITY AND EFFECT OF OLIVE OIL SUPPLEMENTATION Soumaya Loued, O. Helal, T. Saiid, A.J. Rouleau, H. Berrougui, A. Khalil Canada 1.134 COMPARISON OF THEORETICAL AND EXPERIMENTAL RELATIONSHIPS BETWEEN HDL SIZE AND THE RATIO OF HDL CHOLESTEROL (HDL-C) TO APOLIPOPROTEIN A-I (APOA-I) Norman A. Mazer, S. Mora Switzerland 1.135 HISTONE DEACETYLASE (HDAC) INHIBITORS UPREGULATE CLUSTERIN/APOLIPOPROTEIN J EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS (VSMCS) Frank M. Yatsu, K. Ranganna, O.P. Mathew USA 1.136 CHOLESTEROL EFFLUX POTENTIAL OF SERA FROM PATIENTS BEFORE AND AFTER LDL-APHERESIS Elda Favari, M.P. Adorni, F. Sbrana, M. Puntoni, F. Bigazzi, F. Zimetti, F. Bernini, T. Sampietro Italy 1.137 INCREASING CIRCULATING CONCENTRATION OF ALL HDL PARTICLE SUBCLASSES IN HYPER-RESPONDERS TO APOLIPOPROTEIN A-I INDUCTION: INSIGHTS FROM THE ASSERT STUDY Stephen J. Nicholls, A. Gordon, J. Johansson, C.M. Ballantyne, J.J. Kastelein, N.C. Wong, M. Borgman, K. Wolski, S.E. Nissen USA 55 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.138 LYCOPENE REDUCES INFLAMMATION AND IMPROVES HDL FUNCTIONALITY IN OVERWEIGHT INDIVIDUALS J. McEneny, Lauren Wade, A. Mcginty, I. Young, F. Thies UK 1.139 EFFECT OF DALCETRAPIB ON NON-CHOLESTEROL MARKERS OF CHOLESTEROL HOMEOSTASIS IN HEALTHY SUBJECTS Eric J Niesor, E. Chaput, A. Staempfli, M. Derks, D. Kallend Switzerland 1.140 CERAMIDE AS A POTENTIAL LIPIDOME BIOMARKER OF HDL FUNCTIONALITY: RELEVANCE TO POTENT ANTI-APOPTOTIC ACTIVITY IN SMALL, DENSE HDL3 Anatol Kontush, M. Stahlman, M. Lhomme, J. de Souza, J. Boren, M.J. Chapman France 1.141 ARE HDL PARTICLES DYSFUNCTIONAL IN ACUTE CORONARY SYNDROME PATIENTS WITH STEMI AND LOW HDL-CHOLESTEROL LEVELS: IMPACT OF STATIN? Fabiana Hanna Rached, C.V. Serrano Jr, L. Camont, A.L. Pinto, M. Barros, W. Goff, J. Chapman, A. Kontush France, Brazil 1.142 ATORVASTATIN AND HORMONE REPLACEMENT THERAPY AFFECT EXPRESSION OF GENES REGULATING THE REVERSE CHOLESTEROL TRANSPORT IN MONONUCLEAR CELLS FROM POSTMENOPAUSAL WOMEN Alvaro Cerda, F.D. Genvigir, C.B. Rohde, M. Issa, S.A. Cavalli, M.C. Bertolami, M.H. Hirata, R.D. Hirata Brazil 1.143 TANGIER DISEASE: A PLASMA PROTEOME APPROACH Mariarita Puntoni, C. Boccardi, F. Sbrana, S. Rocchiccioli, F. Bigazzi, L. Citti, T. Sampietro Italy 1.144 EFFECT OF EZETIMIBE ON COMPONENTS OF HDL SUBCLASS IN PATIENTS WITH END-STAGE RENAL DISEASE Yasuki Ito, T. Hirano, K. Nohtomi, N. Nakanishi, T. Watanabe, T. Hyodo, T. Taira Japan 1.145 GENE PROFILING ON THE EFFECTS OF HDL ON ACTIVATED HUMAN MONOCYTES Xiao Lei Moore, Y. Fu, I. Haviv, D. Sviridov, J. Chin-Dusting Australia 56 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.146 A NOVEL APOA-I MIMETICS, FAMP CONSTRUCTS PRE-BETA HDL IN VITRO AND IN VIVO Yoshinari Uehara, K. Oniki, H. Tanigawa, S. Abe, S. Ando, E. Yahiro, S.-I. Miura, K. Saku Japan 1.147 CORONARY ANGIOPLASTY CHANGES THE HDL PROTEOME OF PATIENTS WITH CORONARY DISEASE Elena Burillo, I. Jorge, E. Nuñez, R. Mateo-Gallego, P. Martin-Fuentes, A. Cenarro, J. Vazquez, F. Civeira Spain 1.148 ADDITIVE EFFECTS OF NIACIN ON TOP OF SIMVASTATIN TREATMENT IN REDUCING ATHEROSCLEROSIS IN APOE*3LEIDEN.CETP MICE Mieke Louwe, S. Kühnast, J. Smit, L. Havekes, P. Rensen, J. van der Hoorn, H. Princen, W. Jukema The Netherlands 1.149 DETERMINATION OF PARAOXONASE-3 CONCENTRATION IN HUMAN SERUM: METHOD EVALUATION, REFERENCE VALUES AND INFLUENCE OF GENOTYPES IN A POPULATION-BASED STUDY Jordi Camps, G. Aragonès, A. García, M. Barreda, J. Marsillach, R. Beltrán-Debón, A. Rull, B. Mackness, M. Mackness, J. Joven Spain 1.150 REGULAR EXERCISE INCREASED PLASMA PRE-BETA 1-HDL CONCENTRATION IN ADULT WOMEN WITH METABOLIC SYNDROME M. Rosety-Rodriguez, F.J. Ordoñez, I. Rosety, A. Diaz-Ordoñez, M.A. Rosety, A. Camacho, N. Garcia, J. Rosety, Gabriel Fornieles-Gonzalez Spain 1.151 HDL2 LEVELS REDUCE THE ASSOCIATION OF LDL WITH ARTERIAL PROTEOGLYCANS : A NOVEL ANTI-ATHEROSCLEROTIC ROLE OF HDL SUBCLASSES Germán Camejo, B. Rosengren, M. Umaerus, E. Hurt-Camejo Sweden 57 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.152 HDL MODULATES INSULIN SENSITIVITY AND SECRETION DURING ACUTE PHASE OF MYOCARDIAL INFARCTION Luiz Sérgio Fernandes De Carvalho, R.M.R. Cintra, A.L.R. Araújo, F.A. Moura, J.C.Q.E. Silva, O.R. Coelho, A.C. Sposito Brazil 1.153 OLIVE OIL CONSUMPTION EFFECT ON CHOLESTEROL EFFLUX AND INFLAMMATION MARKERS Olfa Helal, H. Berrougui, A. Khalil Canada 1.154 EFFECT OF CHRONIC RENAL FAILURE ON SERUM AND HDL CHOLESTEROL EFFLUX CAPACITY AND MACROPHAGE ABCA1/ABCG1 EXPRESSION Sabine Schreier, M. Hollaus, E. Pemberger, S. Fruhwürth, C. Röhrl, F. Liebscher, B. Englinger, J. Becker, A. Schmidt, H. Scharnagl, C. Aufricht, H. Stangl, W. Strobl Austria 1.155 SKIN AUTOFLUORESCENCE IS INVERSELY RELATED TO HDL ANTI-OXIDATIVE CAPACITY IN TYPE 2 DIABETES MELLITUS Douwe J. Mulder, J.F. De Boer, R. Graaff, R. De Vries, W. Annema, J.D. Lefrandt, A.J. Smit, U.J.F. Tietge, R.P.F. Dullaart The Netherlands 1.156 A HIGH-FAT CHOLESTEROL-CONTAINING DIET PROMOTES REVERSE CHOLESTEROL TRANSPORT FROM MACROPHAGES TO FECES IN VIVO THAT DEPENDS ON ABCG5/G8 Joan Carles Escolà-Gil, G. Llaverias, J. Julve, D. Santos, J. Méndez-González, F. Blanco-Vaca Spain 1.157 THE ANTIATHEROGENIC PROPERTIES OF HDL AFTER BARIATRIC SURGERY Osamah Amin Hussein, I. Shams, K. Abu Jabal, I. Waksman, I. Dashkovsky, S. Szvalb, N. Volkova, B. Fuhrman, M. Aviram Israel 1.158 GLYCOXIDATION IMPAIRS THE HDL-MEDIATED OXYSTEROLS EFFLUX AND INDUCES STEROL ACCUMULATION IN MACROPHAGES Rodrigo Tallada Iborra, A. Machado-Lima, G. Castilho, V.S. Nunes, E.R. Nakandakare, D.S. Abdalla, M. Passarelli Brazil 58 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.159 KEY ROLE OF LOW HDL CHOLESTEROL FOR THE ASSOCIATION OF METABOLIC SYNDROME WITH INFLAMMATION IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE Philipp Rein, J. Ortmann, C.H. Saely, C. Boehnel, S. Beer, A. Vonbank, I. Baumgartner, H. Drexel Austria, Liechtenstein 1.160 HDL LOSES ITS ANTI-INFLAMMATORY PROPERTY AND EVEN INDUCES MORE INFLAMMATION IN S100B OR LPS-STIMULATED MACROPHAGES PREVIOUSLY EXPOSED TO AGE-ALBUMIN Ligia Shimabukuro Okuda, G. Castilho, D.D.F.M. Rocco, E.R. Nakandakare, S. Catanozi, M. Passarelli Brazil 1.161 V156K-APOA-I IN LIPID-BOUND STATE IS MORE RESISTANT TO MODIFICATION OF FRUCTOSYLATION IN STRUCTURAL AND FUNCTIONAL PROPERTIES Jeong-Hye Yoon, K.H. Cho Republic of Korea 1.162 HDL - ASSOCIATED PARAOXONASE 1 (PON1) HYDROLYZING ACTIVITY AGAINST MACROPHAGE OXIDIZED LIPIDS PROTECTS AGAINST MACROPHAGE FOAM CELL FORMATION AND ATHEROGENESIS Michael Aviram Israel 1.163 SERUM PARAOXONASE ESTERASE AND LACTONASE ACTIVITIES CORRELATE WITH INTERMEDIATE SIZE HDL PARTICLES Alejandro Gugliucci, T. Menini, K. Kotani, R. Hermo, R. Caccavello USA 1.164 ROLE OF HOMOCYSTEINE THIOLACTONASE ACTIVITY AND ADMA LEVELS IN HEMODIALYZED AND RENAL TRANSPLANTED PATIENTS György Paragh, F. Sztanek, M. Harangi, L. Lőcsey, J.T. Padra, L. Asztalos, I. Seres Hungary 1.165 INTERRELATIONSHIP BETWEEN LIPID METABOLISM AND MACULAR PIGMENT OPTICAL DENSITY Sanne van der Made, E. Kelly, T. Berendschot, J. Plat, R.P. Mensink The Netherlands 1.166 IMPACT OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITION ON NUCLEAR MAGNETIC RESONANCE DERIVED LIPOPROTEIN PARTICLE PARAMETERS Nina Rashedi, D. Brennan, J.J. Kastelein, S.E. Nissen, S. Nicholls USA 59 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.167 SEX HORMONES MODULATE REVERSE CHOLESTEROL TRANSPORT IN HUMAN MACROPHAGES A.N. Smirnov, T.A. Shchelkunova, I.A. Morozov, P.M. Rubtsov, I.A. Sobenin, I.V. Adrianova, E.G. Rudymov, N.M. Mukhamedova, D.M. Martirosyan, Alexander N. Orekhov Russia 1.168 THE NASCENT HDL-LIKE PARTICLES CONTAINING APO A-I OR APO A-II ARE INDEPENDENTLY GENERATED DURING PHOSPHOLIPIDS MEDIATED HDL REMODELING Anna Wolska, M. Czyżewska, K. Wołoszyn, A. Szutowicz, M. Wróblewska Poland WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES 1.169 A RAPID EVALUATION MODEL FOR INFLAMMATORY DEATH USING ZEBRAFISH LARVAE BY OXIDIZED LOW-DENSITY LIPOPROTEIN AND DYSFUNCTIONAL HIGH-DENSITY LIPOPROTEINS J. Park, K.H. Park, Kyung-Hyun Chos Republic of Korea 1.170 APOLIPOPROTEIN M BINDS OXIDIZED PHOSPHOLIPIDS AND INCREASES THE ANTIOXIDANT EFFECT OF HDL Sara Elsoe Nielsen, J. Ahnström, C. Christoffersen, A.N. Hoofnagle, P. Plomgaard, J.W. Heinecke, H. Björkbacka, B. Dahlbäck, L.B. Nielsen Denmark 1.171 ANTI-ATHEROGENIC EFFECTS OF PERSIMMON (DIOSPYROS KAKI) PEEL IN LDLR-/--DEFICIENT MICE: PLAQUE REDUCTION, INHIBITION OF OXLDL/Β2GPI AUTOANTIGEN AND THROMBOXANE PLATELET ACTIVATION Eiji Matsuura, N. Quan, K. Kobayashi, Y. Matsunami, M. Ide, M. Makarova, L. Shen, S. Ohno, Y. Zheng, H. Kobayashi, L.R. Lopez Japan 1.172 VITAMIN K ROLE IN ARTERIAL STIFFNESS DURING METABOLIC SYNDROME IN RAT: DIRECT OR INDIRECT EFFECT VIA LIPID METABOLISM Léa Emonnot, N. Côté, P. Mathieu, É. Levy, P. Moreau Canada 60 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES (contd.) Poster No 1.173 OXIDIZED LDL TRIGGER ENDOPLASMIC RETICULUM STRESS AND AUTOPHAGY : PREVENTION BY HDL Cécile Vindis, C. Muller, R. Salvayre, A. Nègre-Salvayre France 1.174 PKC Γ IS INVOLVED IN OXIDIZED LDLS -INDUCED APOPTOSIS OF VASCULAR SMOOTH MUSCLE CELLS Cécile Ingueneau, P. Larroque, M.E. Reyland, R. Salvayre, A. Nègre-Salvayre, C. Vindis France, USA 1.175 PHOSPHATIDYLCHOLINE HYDROPEROXIDE-INDUCED RAC ACTIVATION: ITS INVOLVEMENT IN THP-1 CELL ADHESION TO ICAM-1 VIA ACTIN POLYMERIZATION Akira Asai, K. Nakagawa, F. Okajima, Y. Nakajima, M. Nagao, T. Miyazawa, S. Oikawa Japan 1.176 APOE*3LEIDEN.CETP TRANSGENIC MICE AS MODEL FOR THE METABOLIC SYNDROME A.M. van den Hoek, J.W.A. van der Hoorn, M.C.E. Maas, C.M. van den Hoogen, A. van Nieuwkoop, E.O. Offerman, E.J. Pieterman, L.M. Havekes, H.M.G. Princen The Netherlands WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) 1.177 DOES APO A-II CYCLE BETWEEN MATURE Α-HDL AND NASCENT PRE-Β HDL A-II PARTICLES? Anna Wolska, M. Czyżewska, K. Wołoszyn, A. Szutowicz, M. Wróblewska Poland 1.178 HDL FROM ELDERLY AND RECONSTITUTED HDL CONTAINING GLYCATED APOLIPOPROTEINS A-I SHARE PRO-ATHEROSCLEROTIC AND PRO-SENESCENT PROPERTIES WITH INCREASED CHOLESTEROL INFLUX K.H. Park, Kyung-Hyun Cho Republic of Korea 1.179 PARAOXONASE AND HOMOCYSTEINE THIOLACTONASE ACTIVITIES AND ASYMMETRIC DIMETHYL-ARGININE (ADMA) LEVEL IN HEMODIALYZED PATIENTS Ildikó Seres, F. Sztanek, L. Lőcsey, M. Harangi, G. Paragh Hungary 61 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.180 TRANSFER OF LIPIDS TO HDL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH AND WITHOUT CORONARY ARTERY DISEASE Marilia C.O. Sprandel, W.A. Hueb, A. Casella-Filho, C.A. Segre, F.R. Freitas, R.C. Maranhão Brazil 1.181 ITINERARY OF HIGH DENSITY LIPOPROTEINS AND APOLIPOPROTEIN A-I TRANSPORT THROUGH THE ENDOTHELIUM Damir Perisa, L. Rohrer, A. von Eckardstein Switzerland 1.182 MODIFIED APOLIPOPROTEIN (APO) A-I BY ARTIFICIAL SWEETENER CAUSES SEVERE PREMATURE CELLULAR SENESCENCE AND ATHEROSCLEROSIS Juyi Seo, K.H. Cho Republic of Korea 1.183 LOW HDL IN SOUTH ASIAN IMMIGRANTS: COULD DYSFUNCTIONAL HDL BE THE MISSING LINK? S. Dodani, Lei Dong, S. Reddy USA 1.184 REVERSE CHOLESTEROL TRANSPORT KEY PROTEINS AND ATHEROSCLEROSIS Ekaterina Demina, V. Miroshnikova, A. Denisenko, A. Schvarzman Russia 1.185 SERUM PARAOXONASE PHENOTYPE DISTRIBUTION IN EXUDATIVE AGE RELATED MACULAR DEGENERATION AND ITS RELATIONSHIP TO HOMOCYSTEINE AND OXIDIZED LOW DENSITY LIPOPROTEIN Amir Ghorbanihaghjo, A. Javadzadeh, E. Bahreini, N. Rashtchizadeh, H. Argani, S. Alizadeh Iran 1.186 UNFOLDING OF EXCHANGEABLE APOLIPOPROTEINS Alexander Dergunov Russia 1.187 CHANGES IN FUNCTION AND STRUCTURE OF HIGH-DENSITY LIPOPROTEIN IN OBESE PATIENTS COMPARED WITH HEALTHY CONTROLS Salam Hama, H. Soran, Y. Liu, V. Charlton-Menys, R. Zadeh, M. France, R. Yadav, M. Jeziorska, B. Ammori, P. Durrington UK 62 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: MECHANISMS FOR THE PROTECTIVE ROLE OF HDL (contd.) Poster No 1.188 ASSESSMENT OF 2 METHODS FOR ISOLATION OF HIGH-DENSITY LIPOPROTEIN (HDL) Salam Hama, H. Soran, V. Charlton-Menys, Y. Liu, R. Yadav, M. France, B. Ammori, P. Durrington UK 1.189 HDL CHOLESTEROL/ APOLIPOPROTEIN AI RATIO INVERSELY LINKED WITH ACUTE CORONARY SYNDROME, INDEPENDENT TO HDL CHOLESTEROL Sung Yoon Lim, H.-S. Seo, E.J. Kim, J.O. Na, C.U. Choi, H.E. Lim, S.W. Rha, C.G. Parl, D.J. Oh Republic of Korea 1.190 RELATIONSHIP BETWEEN ALBUMINURIA AND SERUM LIPIDS IN TYPE 1 DIABETES MELLITUS T. Bulum, Ingrid Prkačin, L. Duvnjak Croatia 1.191 IMPAIRED HIGH-DENSITY LIPOPROTEIN ANTIOXIDANT CAPACITY IN TYPE II DIABETES Raveenan Mingpakanee, N. Charoensa, Y. Phrawisat, W. Dahlan Thailand 1.192 CARDIOVASCULAR PARAMETERS IN HIV POSITIVE PATIENTS WITH CHRONIC PERIODONTITIS R.V. Orellana, Andrea Monteiro, M.A. Gidlund, A. Mantesso, Eduardo Ramos Samches, Henrique Fonseca Brazil 1.193 SPECIFIC AGONIST OF THE CONSTITUTIVE ANDROSTANE RECEPTOR IMPROVES REVERSE CHOLESTEROL TRANSPORT AND CHOLESTEROL HOMEOSTASIS IN HYPERLIPIDEMIC MICE D. Masson, A.L. Sberna, T. Gautier, J. Grober, A. Athias, M. Assem, L. Lagrost France WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES 1.194 SUBCLINICAL HYPOTHYROIDISM IS RELATED TO A SPECIFIC LIPID PROFILE INDEPENDENTLY OF TSH LEVELS Antonio Hernández-Mijares, A. Jover, C. Bañuls, M. Rocha, E. Solá, L. Bellod Spain 1.195 AMLODIPINE RESTORES ENDOTHELIAL FUNCTION ALTERED BY IRREVERSIBLY GLYCATED LOW DENSITY LIPOPROTEINS Laura Toma, C.S. Stancu, G.M. Sanda, A.V. Sima Romania 63 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES (contd.) Poster No 1.196 ANALYSIS OF EICOSANOIDS IN HUMAN LDL BEFORE AND AFTER CU-INDUCED OXIDATION Juliane Dorow, L. Kortz, S. Becker, J. Thiery, S. Hauschildt, U. Ceglarek Germany 1.197 A GENETIC VARIANT WITHIN CAVEOLIN-3 PROTECTS AGAINST STATIN-INDUCED MYOPATHY Eleni Giannakidou-Jordan, C. Gelsinger, U. Kassner, H. Knoblauch, S. Spuler, A. Busjahn, E. Steinhagen-Thiessen Germany 1.198 DIFFERENTIAL EFFECT OF ASPIRIN ON OXIDATIVE STRESS, THROMBOXANE, NITRIC OXIDE METABOLITES AND P-SELECTIN IN TYPE 2 DIABETES MELLITUS Luis R Lopez, I. Muncy, E. Matsuura, J. Batuca, A. Oregon-Miranda, I. Garcia De La Torre, P.R. Ames USA 1.199 LDL FROM PATIENTS WITH METABOLIC SYNDROME OR TYPE 2 DIABETES SHOW INCREASED LIPID PEROXIDATION AND ACTIVATE PLATELETS Catherine Calzada, R. Colas, M. Guichardant, A. Sassolas, C. Cugnet-Anceau, M. Moret, P. Moulin, M. Lagarde France 1.200 DO MTTP MUTATIONS OVERCOME HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA? SEGREGATION ANALYSIS IN A FAMILY WITH BOTH LDLR AND MTTP MUTATIONS Mathilde Di Filippo, N. Peretti, P. Moulin, C. Jacobs, S. Chebel, A. Lachaux, A. Sassolas France 1.201 PLAQUE OXYSTEROLS INDUCE IMBALANCED UP-REGULATION OF MMP-9 IN MACROPHAGIC CELLS THROUGH REDOX-SENSITIVE SIGNALING PATHWAYS Simona Gargiulo, P. Gamba, B. Sottero, G. Poli, G. Leonarduzzi Italy 1.202 SAFETY PROFILE OF STATINS ALONE OR COMBINED WITH EZETIMIBE: A POOLED ANALYSIS OF OVER 21,000 PATIENTS Peter P Toth, W. Weintraub, D. Morrone, M.E. Hanson, R.S. Lowe, J. Lin, A. Shah, A.M. Tershakovec USA 64 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES (contd.) Poster No 1.203 PITAVASTATIN HAS PLEIOTROPIC ANTI-OXIDATIVE AND ANTI-INFLAMMATORY BENEFITS IN PATIENTS WITH DYSLIPIDAEMIA: RESULTS FROM A PHASE III STUDY PROGRAMME Neil Hounslow UK 1.204 CORRELATION BETWEEN LP(A) AND PARAOXONASE IN PSORIASIS Gianna Ferretti, T. Bacchetti, A. Campanati, O. Simonetti, A. Offidani Italy 1.205 EFFECT OF EZETIMIBE ON MARKERS OF OXIDATIVE STRESS IN PATIENTS WITH HYPERCHOLESTEROLEMIA Michael S Kostapanos, A.T. Spyrou, C.C. Tellis, I.F. Gazi, A.D. Tselepis, E.N. Liberopoulos, M.S. Elisaf Greece 1.206 ASSOCIATION OF HYPERTENSION WITH SMALL, DENSE LOW-DENSITYLIPOPROTEIN IN PATIENTS WITHOUT METABOLIC SYNDROME Yun Kyung Kim, H.S. Seo, J.O. Na, C.U. Choi, H.E. Lim, E.J. Kim, S.W. Rha, C.G. Park, D.J. Oh Republic of Korea 1.207 LIPID PROFILE IN PATIENTS WITH INFLAMMATORY POLYARTHRITIS PRIOR TO THERAPY Awal Zaki Alhusain, S.M. Verstappen, H. Mirjafari, D. Symmons, V. Charlton-Menys, P. Durrington, D. Bunn, I.N. Bruce UK 1.208 PROTEIN DISULFIDE ISOMERASE INHIBITION BY 4-HYDROXYNONENAL-ADDUCTS CONTRIBUTES TO OXIDIZED LOW DENSITY LIPOPROTEIN-INDUCED APOPTOSIS C. Muller, J. Bandemer, C. Vindis, R. Salvayre, Anne Negre-Salvayre France 1.209 INDUCTION OF CYTOSKELETON REORGANISATION BY OX-LDL MEDIATES ID1DEPENDENT ANGIOGENESIS Juhui Qiu, G. Wang, J. Hu, Y. Zheng, Q. Peng, X. Luo, C. Tang China 1.210 THE CORRELATION BETWEEN APOLIPOPROTEINS B/A1 RATIO AND ARTERIAL STIFFNESS IN THE PATIENTS WITH HYPERTENSION Lucia Agoston-Coldea, S. Lupu, T. Mocan Romania 1.211 LDL-APHERESIS FOR PREVENTION OF RECURRENT HYPERTRIGLYCERIDEMIAINDUCED ACUTE PANCREATITIS, A CASE REPORT A. Saad, Patrick Moriarty USA 65 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES (contd.) Poster No 1.212 INCREASED LEVELS OF LOW-DENSITY LIPOPROTEIN S-HOMOCYSTEINYLATION IN CHRONIC KIDNEY DISEASE (CKD) Angelo Zinellu, G. Loriga, A.E. Satta, L. Deiana, C. Carru Italy 1.213 CHANGES OF PLASMA ADIPONECTIN LEVEL AND LIPID PROFILE IN SEVERELY OBESE PATIENTS BEFORE AND AFTER BARIATRIC SURGERY Mohammad Javad Hosseinzadeh-Attar, A. Golpaie, M. Hosseini, H. Darakhshanian, M. Talebpour Iran 1.214 INVESTIGATION OF THE PATHOGENESIS OF ATHEROSCLEROSIS: ASSOCIATION BETWEEN OXIDIZED LOW DENSITY LIPOPROTEINS AND ATHEROSCLEROSIS RISK FACTORS Zita Aušrelė Kučinskienė, L. Bagdonaite Lithuania 1.215 IRREVERSIBLY GLYCATED LDL INCREASE INTRACELLULAR FREE CALCIUM CONCENTRATION IN HUMAN VASCULAR SMOOTH MUSCLE CELLS Gabriela Maria Sanda, C.S. Stancu, A.V. Sima Romania 1.216 CLONING AND EXPRESSION OF A FLUOBODY RECOGNIZING MINIMALLY MODIFIED LOW-DENSITY LIPOPROTEIN Tanize Espírito Santo Faulin, V.R. Hering, M.J. Politi, D.S.P. Abdalla Brazil 1.217 THE EFFECT OF PITAVASTATIN AND PRAVASTATIN ON THE SERUM PHOSPHATIDYLCHOLINE HYDROPEROXIDE (PCOOH) CONCENTRATION Shinichi Oikawa, F. Okajima, A. Asai, Y. Ishigaki, Y. Oka, S. Kono, J. Sasaki, H. Sugihara, K. Nakagawa, T. Miyazawa Japan 1.218 THE ROLE OF CARDORIUM PLUS ON SERUM LIPIDS, INFLAMMATION AND OXIDATIVE STRESS IN HYPERLIPIDEMIC BROILER CHICKS Murty S S G P M V R Devarakonda, Rajesh Enjamoori India 1.219 MULTIPLEX MASSARRAY SPECTROMETRY ASSAY FOR DETECTING 36 FH MUTATIONS/POLYMORPHISMS IN GREEK AND CYPRIOT PATIENTS Evy Bashiardes, S. Xenophontos, G. Miltiadous, M. Elisaf, M. Cariolou Cyprus 66 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Area WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES (contd.) Poster No 1.220 OXIDIZED PHOSPHOLIPIDS (OXPLS) INDUCE PRODUCTION OF STEM CELL FACTOR (SCF) AND ACTIVATION OF ITS RECEPTOR C-KIT IN ENDOTHELIAL CELLS Taras Afonyushkin, O.V. Oskolkova, V.N. Bochkov Austria 1.221 METABOLIC SYNDROME IN SOUTH ASIAN IMMIGRANTS: MORE THAN LOW HDL REQUIRING AGGRESSIVE MANAGEMENT Sunita Dodani, M. Butler, J. Vacek, K. Gupta USA 1.222 LONG CHAIN N-3 POLYUNSATURATED FATTY ACIDS (LCN3PUFA), EICOSAPENTAENOIC ACID (EPA) AND DOCOSAHEXAENOIC ACID (DHA), MODULATE HUMAN THP-1 MACROPHAGE CHOLESTEROL LEVELS Sheila McCartan, A. McGinty, B. Green, C. Mercer, J. McEneny, L.A. Powell UK 1.223 APOLIPOPROTEIN B OF LOW-DENSITY LIPOPROTEIN REDUCES NITRIC OXIDEMEDIATED ENDOTHELIUM-DEPENDENT RELAXATION IN RAT MESENTERIC ARTERIES Cang-Bao Xu, W. Zhang, Y. Zhang, L. Edvinsson Sweden 1.224 HEALTH EFFECTS OF OXIDIZED COD LIVER OIL IN HEALTHY SUBJECTS: A RANDOMIZED CONTROLLED TRIAL Inger Ottestad, G. Vogt, M. Myhrstad, K. Retterstøl, A. Nilsson, J.E. Haugen, G. Ravn-Haren, K.W. Brønner, L.F. Andersen, K. Holven, S. Ulven Norway 1.225 PLASMA MALONDIALDEHYDE MEASUREMENT BY FIELD-AMPLIFIED SAMPLE STACKING (FASI) CAPILLARY ELECTROPHORESIS UV DETECTION A. Zinellu, B. Scanu, E. Pisanu, M. Sanna, V. De Murtas, M.A. Pinna, D. Cambedda, L. Deiana, Ciriaco Carru Italy 67 Lipids, Lipoproteins and Lipid Metabolism Poster Session Lipids, Lipoproteins and Lipid Metabolism Poster Session Poster Area WORKSHOP: REACTIVE LIPID COMPOUNDS AND MODIFIED LIPOPROTEINS IN DISEASE PROCESSES (contd.) Poster No 1.226 OX-LDL INHIBITS THE MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS VIA UP-REGULATION OF P53 EXPRESSION Jianjun Hu, G. Wang, J. Qiu, Y. Zheng, Y. Teng, H. Chen, C. Tang, T. Yin China 1.227 THE EFFECT OF OXIDATIVE STRESS UPON MEMBRANE AND CYTOPLASMIC LIPIDS PEROXIDATION IN ERYTHROCYTES FROM PATIENTS WITH CARDIOVASCULAR AND CEREBROVASCULAR PATHOLOGIES Cristian Romeo S. Revnic, C. Ginghina, F.G. Revnic, G. Prada, S. Prada, C. Pena, S. Botea Romania 1.228 YOUNGER PATIENTS WHO UNDERWENT MYOCARDIAL INFARCTION, HAD INCREASED LEVELS OF OXIDATION-SUSCEPTIBLE LIPIDS Pawel Burchardt, B. Zuchowski, H. Wysocki Poland 1.229 EFFECT OF N-3 FATTY ACIDS AND STATINS ON OXIDATIVE STRESS IN STATINTREATED HYPERCHOLESTORELEMIC AND NORMOCHOLESTEROLEMIC WOMEN M. Carrapeiro, M. Rogero, M. Bertolami, P. Botelho, N. Castro, Inar Castro Brazil 1.230 THE EFFECT (OF IDENTICAL TO THE TYPE AND DOSE) OF STATINS TREATMENT IN PATIENTS WITH CAD DEPENDS ON SMOKING Pawel Burchardt, B. Zuchowski, A. Palasz, H. Wysocki Poland 1.231 EZETIMIBE IMPROVES NAFLD AGGRAVATION INDUCED BY DIETARY CHOLESTEROL OXIDATION PRODUCTS IN NON-HUMAN PRIMATES Michiyo Deushi, K. Nakano, K. Osada, T. Kaizuka, K. Egashira, M. Yoshida Japan 68 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS 2.01 OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN (ORP8) - A NEW PROATHEROGENIC FACTOR? Olivier Beaslas, E. van Kampen, T. Vihervaara, G. Liebisch, R.B. Hildebrand, G. Schmitz, M. Van Eck, V.M. Olkkonen Finland 2.02 TARGETED GENE DELETION IN THE TGF-BETA SIGNALING PATHWAY AFFECTS ATHEROSCLEROSIS AND TH17 CELL DIFFERENTIATION IN HYPERCHOLESTEROLEMIC MICE Anton Gisterå, A.K. Robertson, J. Andersson, D.F.J. Ketelhuth, A.M. Lundberg, M.O. Li, R.A. Flavell, G.K. Hansson Sweden 2.03 NANO- AND MICRO-STRUCTURE OF CALCIFICATION IN HUMAN AORTIC VALVE, AORTA AND CORONARY WALL Sergio Bertazzo, K.L. Cloyd, E. Gentleman, I. El-Hamamsy, A.H. Chester, M.H. Yacoub, M.M. Stevens UK 2.04 OSTEOPONTIN IS IMPORTANT FOR DEVELOPMENT OF UREMIC ATHEROSCLEROSIS Tanja Xenia Pedersen, N. Junker, M. Madsen, S. Bro, A. Hultgaardh-Nilsson, L.B. Nielsen Denmark 2.05 SERINE PROTEASE INHIBITOR A3 INFLUENCES AORTIC ANEURYSM FORMATION BUT NOT ATHEROSCLEROSIS Dick Wågsäter, D. Johansson, X. Zhou, P. Eriksson Sweden 2.06 GLYCATED HEMOGLOBIN FOR THE DIAGNOSIS OF TYPE 2 DIABETES IN PERSONS UNDERGOING CORONARY ANGIOGRAPHY: THE LURIC STUDY Guenther Silbernagel, M.E. Kleber, T.B. Grammer, B.R. Winkelmann, B.O. Boehm, W. März Germany 69 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.07 SPONTANEOUS PLAQUE DISRUPTIONS, DISSECTION, EROSION AND INTRAPLAQUE HEMORRHAGE IN MURINE VEIN GRAFTS CAN BE ATTENUATED BY TIMP-1 OVEREXPRESSION Margreet R. de Vries, H.W.M. Niessen, C.W. Löwik, J.W. Jukema, P.H.A. Quax The Netherlands 2.08 THE INFLUENCE OF INTRACORONARY INJECTION OF MONONUCLEAR BONE MARROW CELLS ON PROTHROMBOTIC MARKERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Svein Solheim, I. Seljeflot, K. Lunde, S. Aakhus, V. Bratseth, K. Forfang, H. Arnesen Norway 2.09 SOLUBLE FORM OF THE ENDOTHELIAL ADHESION MOLECULE CD146 BINDS PREFERENTIALLY PROINFLAMMATORY-PROATHEROSCLEROTIC CD16+ MONOCYTE SUBSET Chiara Barisione, G. Ghigliotti, P. Fabbi, P. Altieri, C. Brunelli, P. Spallarossa, A. Barsotti, S. Garibaldi Italy 2.10 ISOPRENOID PATHWAY INHIBITORS BLOCK INNATE PATHWAYS OF IMPORTANCE FOR EARLY ATHEROGENESIS Harald Loppnow, M. Buerke, A. Schlitt, U. Müller-Werdan, K. Werdan Germany 2.11 INFLAMMATORY MARKERS AND DISEASE SEVERITY IN PATIENTS WITH CHRONIC HEART FAILURE. LIMITED EFFECTS OF EXERCISE TRAINING Rune Byrkjeland, B.B. Nilsson, A.S. Westheim, H. Arnesen, I. Seljeflot Norway 2.12 SPECIFIC LP(A) APHERESIS FOR CAROTID ATHEROSCLEROSIS STABILIZATION IN CHD PATIENTS WITH ELEVATED LP(A) LEVELS Maya Safarova, M. Ezhov, O. Afanasieva, T. Balakhonova, I. Adamova, G. Konavalov, S. Pokrovsky Russia 70 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) 2.13 CATECHOL-O-METHYLTRANSFERASE (COMT) IS DISPENSABLE FOR VASCULAR PROTECTION BY ESTRADIOL IN MICE Anna S. K. Wilhelmson, J. Bourghardt, P. Fogelstrand, J.A. Gogos, Å. Tivesten Sweden 2.14 LONG-TERM TREATMENT WITH LOW-DOSE METOPROLOL CR/XL IS ASSOCIATED WITH INCREASED PLAQUE ECHOGENICITY: THE BETA-BLOCKER CHOLESTEROLLOWERING ASYMPTOMATIC PLAQUE STUDY (BCAPS) Gerd Östling, I. Gonçalves, J. Wikstrand, G. Berglund, J. Nilsson, B. Hedblad Sweden 2.15 INFLAMMATION, LEUKOCYTE ACTIVATION, AND SURROGATE ATHEROSCLEROSIS MARKERS IN RHEUMATOID ARTHRITIS PATIENTS ARE RELATED TO MITOCHONDRIAL DEPOLARISATION AND OXIDATIVE STRESS Chary Lopez-Pedrera, C. Perez-Sanchez, P. Ruiz-Limón, M.A. Aguirre, R.M. Carretero, N. Barbarroja, A. Rodriguez-Ariza, E. Collantes-Estevez, J.M. Villalba, F. Velasco, M. Khamashta, M.J. Cuadrado Spain 2.16 IN VITRO DIFFERENTIATION OF BONE MARROW-DERIVED PORCINE MESENCHYMAL STEM CELLS INTO ENDOTHELIAL CELLS: POTENTIAL ROLE OF CANONICAL WNT SIGNALING PATHWAY Devendra K Agrawal, D. Pankajakshan, V. Kansal USA 2.17 EFFECTS OF LOW-DOSE TNF-Α-ADMINISTRATION ON OXIDATIVE/NITROSATIVE STRESS, THE AKT/ENOS/NO PATHWAY AND VIABILITY IN CARDIAC ENDOTHELIAL CELLS Hans Strijdom, A. Genis, M. Mudau, C. Westcott, A. Lochner South Africa 2.18 AN ASSOCIATION OF MUTATIONS OF MITOCHONDRIAL DNA WITH AORTIC ATHEROSCLEROTIC LESIONS Igor Sobenin M.A. Sazonova, A.Y. Postnov, A.N. Orekhov Russia 2.19 THE JAK2 INHIBITOR-TYRPHOSTIN AG490 DOWN-REGULATES NAPDH OXIDASE ACTIVITY AND EXPRESSION IN THE AORTA OF HYPERCHOLESTEROLEMIC APOEDEFICIENT MICE Monica Raicu, I.M. Fenyo, I.C. Florea, A. Manea Romania 71 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.20 RESISTIN UP- REGULATES FRACTALKINE AND CX3CR1 EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS BY MAPK - NF-KB PATHWAY Ana-Maria Gan, I. Manduteanu, V. Simion, D. Stan, M.M. Pirvulescu, M. Calin, E. Butoi, M. Simionescu Romania 2.21 RELATION OF EPICARDIAL ADIPOSE TISSUE TO CORONARY ATHEROSCLEROSIS IS REGION-SPECIFIC AND INDEPENDENT OF CONVENTIONAL RISK FACTORS AND INTRA-ABDOMINAL ADIPOSITY Tzung-Dau Wang, W.J. Lee, W.J. Chen, M.F. Chen Taiwan R.O.C. 2.22 PREDICTION OF LDL TRANSPORT AND PLAQUE FORMATION IN THE CAROTID ARTERY Nenad Filipovic, N. Meunier, M. Rosic, I. Tanaskovic, D. Fotiadis Serbia 2.23 A ROLE FOR OXIDATIVE STRESS IN CIGARETTE SMOKE-INDUCED ELEVATION OF OSTEOPONTIN IN CULTURED ENDOTHELIAL CELLS Emma Louise Bishop, I.M. Fearon UK 2.24 PLEIOTROPIC EFFECTS OF NIACIN THERAPY IN ADDITION TO ATORVASTATIN IN CORONARY HEART DISEASE PATIENTS WITH ELEVATED LIPOPROTEIN(A) LEVELS Maya Safarova, E. Trukhacheva, M. Ezhov, O. Afanasieva, M. Tripoten, S. Pokrovsky Russia 2.25 ATHEROPROTECTIVE EFFECTS OF ADIPONECTIN OVER-EXPRESSION IN A MODEL OF ANGII-ACCELERATED ATHEROSCLEROSIS C.M.W. van Stijn, J. Kim, D. Becerra, Rajendra K. Tangirala USA 2.26 CORONARY ARTERY CALCIFICATION AND DIABETES MELLITUS: SEXSPECIFIC IMPACT ON INCIDENCE OF CARDIOVASCULAR DISEASE - RESULTS OF THE HEINZ NIXDORF RECALL-STUDY Susanne Moebus, S. Möhlenkamp, N. Dragano, U. Slomiany, S. Pechlivanis, R. Erbel, K. Mann, K.H. Jöckel, Heinz Nixdorf Recall Study Group Germany 2.27 A POSSIBLE LINK BETWEEN ATHEROSCLEROTIC PLAQUE INFLAMMATION AND VISCERAL FAT INFLAMMATION Sung Eun Kim, E.J. Kim, J.S. Yeo, H.S. Seog Republic of Korea 72 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) 2.28 UROKINASE PLASMINOGEN ACTIVATOR (UPA) AND ATHEROSCLEROSIS Bianca Fuhrman, J. Khateeb, Y. Lati, M. Aviram Israel 2.29 ACCELERATED ATHEROSCLEROSIS IN FEMALE MICE LACKING THE ANDROGEN RECEPTOR Johan Bourghardt, A. Wilhelmson, C. Alexanderson, K. De Gendt, G. Verhoeven, A. Holmäng, A. Krettek, S.O. Olofsson, C. Ohlsson, Å. Tivesten Sweden 2.30 ATHEROSCLEROSIS REGRESSION IN A MOUSE MODEL WITH HUMAN-LIKE HYPERCHOLESTEROLEMIA J. Björkegren, S. Hägg, S. Maleki, M. Shang, T. Michoel, Josefin Skogsberg Sweden 2.31 TRANSCRIPTOMIC ANALYSIS OF MACROPHAGE POLARIZATION: ROLE OF PPARY IN ALTERNATIVE ACTIVATION Eleonora Derlindati, D. Ardigò, I. Zavaroni Italy 2.32 ENHANCED EXPRESSION OF SIRT1 IN ATHEROSCLEROTIC PLAQUES IS INVOLVED IN THE PATHOGENESIS OF ACUTE CORONARY SYNDROMES Kinta Hatakeyama, Y. Sato, T. Tsuruda, Y. Sekita, K. Nishihira, Y. Shibata, Y. Asada Japan 2.33 EXPOSURE OF HUMAN MACROPHAGES TO TOBACCO SMOKE INDUCES MMP14 EXPRESSION AND GENERATION OF PROTEOLYTICALLY ACTIVE MICROVESICLES C. Li, Y. Liu, D. Yu, K.J. Williams, Ming-Lin Liu USA 2.34 OVEREXPRESSION OF ABCA1 IN HUMAN PLAQUES EXPOSED TO HYPERCHOLESTEROLEMIA: ROLE OF MICRORNA MODULATION Claudia Mandolini, D. Santovito, F. Buttitta, V. De Nardis, A. Marchetti, L. Felicioni, M. Bucci, S. Ucchino, A. Mezzetti, F. Cipollone Italy 2.35 CHOLESTEROL CONTENT OF ERYTHROCYTE MEMBRANES IS ASSOCIATED WITH LIPID CORE SIZE IN ANIMAL MODEL OF ATHEROSCLEROSIS Dimitrios Tziakas, A. Kapelouzou, G. Chalikias, D. Stakos, S. Apostolakis, A. Agapaki, A. Kostakis, H. Boudoulas, S. Konstantinides Greece 2.36 THERAPEUTIC REGRESSION OF ATHEROSCLEROSIS Ahsan Ali, E. Grinevich, A. Mansharipova Kazakhstan 73 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.37 IMPACT OF LOWER LIMB REVASCULARIZATION ON AORTIC AUGMENTATION INDEX AND SUBENDOCARDIAL VIABILITY RATIO IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE Vincenzo Jacomella, A. Shenoy, K. Mosimann, M. Kohler, C. Thalhammer, B. Amann-Vesti, M. Husmann Switzerland 2.38 PHARMACOLOGICAL INHIBITION OF JAK/STAT SIGNALING PREVENTS HIGHGLUCOSE-INDUCED UP-REGULATION OF ENDOTHELIN-1 EXPRESSION IN HUMAN ENDOTHELIAL CELLS Simona Manea, A. Manea, C. Heltianu Romania 2.39 METOPROLOL REDUCES PRO-INFLAMMATORY CYTOKINES AND ATHEROSCLEROSIS IN APOE-/- MICE Maria E Johansson, E. Bernberg, M.A. Ulleryd, G. Bergström Sweden 2.40 THE LEGACY OF METABOLIC MEMORY AND THE ACTIVATION OF PROINFLAMMATORY GENES ARE ASSOCIATED WITH EPIGENETIC PERSISTENCE Assam El-Osta Australia 2.41 EARLY CHANGES IN VASCULAR SMOOTH MUSCLE CELLS GENE EXPRESSION PROFILE IN RESPONSE TO VASCULAR INJURY Anton Fedorov, A. Razuvaev, A. Kostareva, U. Hedin, J. Raud, J. Roy Russia, USA 2.42 KYNURENINE PATHWAY - A NEW LINK BETWEEN ENDOTHELIAL DYSFUNCTION AND CAROTID ATHEROSCLEROSIS IN CHRONIC KIDNEY DISEASE PATIENTS Krystyna Pawlak, M. Mysliwiec, D. Pawlak Poland 2.43 EXTRACORONARY ATHEROSCLEROSIS: RELATIONSHIP WITH VASCULAR ALTERATIONS AND LIPOPROTEIN (A) Rocio Toro, P. Gomez, M. Virseda, I. Tinoco, C. Rodriguez Leal, A. Mangas Spain 2.44 SUPPRESSOR OF CYTOKINE SIGNALING-3 AND INTIMAL HYPERPLASIA IN PORCINE CORONARY ARTERIES FOLLOWING CORONARY INTERVENTION Devendra K Agrawal, G.K. Gupta, M.G. DelCore, G.I. Hatzoudis USA 2.45 EFFECTS OF CIGARETTE SMOKE AND ITS INTERACTION WITH LDL IN A 3DIMENSIONAL COCULTURE MODEL OF PLAQUE DEVELOPMENT Yvonne Steffen, D. Weiss, S. Lebrun, K. Stolle, M. Lietz, J. Schueller, T. Wallerath Germany 74 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) 2.46 THE APOE-/- MOUSE AS A CIGARETTE SMOKE-RESPONSIVE ATHEROSCLEROSIS MODEL SHOWING REVERSIBILITY UPON SMOKING CESSATION Katrin Stolle, M. Lietz, Y. Steffen, H. Weiler, M. Möhring, A. Berges, S. Lebrun Germany 2.47 DOUBLE NEGATIVE T CELLS IN ANGIOTENSIN II DEPENDENT HYPERTENSION Tomasz Mikołajczyk, R. Nosalski, A. Sagan, D. Skiba, D. Ludew, P. Matusik, R. Korbut, T. Guzik Poland 2.48 PERIPHERAL ARTERIAL DISEASE IN METABOLIC SYNDROME (METS): PREDOMINANT LOCALIZATION OF ATHEROSCLEROSIS, HORMONE ABNORMALITY AND CARDIOVASCULAR COMORBIDITY Vladimir Andreev, V. Zelinsky Russia 2.49 DARBEPOETIN ENHANCES ENDOTHELIUM-DEPENDENT VASOMOTOR FUNCTION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE ONLY AFTER PRECEDING ISCHAEMIA-REPERFUSION Lindsey Tilling, J. Hunt, A. Donald, B. Clapp, P. Chowienczyk UK 2.50 RELATION OF MATRIX METALLOPROTEINASES (MMPS)-POSITIVE MACROPHAGES TO CORONARY PLAQUE FRAGILITY AND CORONARY ARTERIAL OUTWARD REMODELING T. Ito, S. Yamada, N. Hirayama-Kuniyoshi, Masashi Shiomi Japan 2.51 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2-INHIBITION PREVENTS ENDOTHELIAL SUSCEPTIBILITY TO TNF-Α UNDER CHRONIC NONUNIFORM SHEAR STRESS Katharina Urschel, W.G. Daniel, C.D. Garlichs, I. Cicha Germany 2.52 THE GUT MICROBIOTA MODULATES ATHEROSCLEROSIS PROGRESSION IN MALE APOE-/- MICE Frida Fåk, C. Reinhardt, F.P. Martin, F. Bäckhed Sweden 2.53 ALCOHOL INHIBITS NOTCH SIGNALING IN VASCULAR SMOOTH MUSCLE CELLS AT THE LEVEL OF γ-SECRETASE D. Morrow, J. Cullen, P. Cahill, Eileen Redmond USA 75 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.54 CB2 RECEPTOR SIGNALING DOES NOT MODULATE ATHEROGENESIS IN MICE Florian Willecke, K. Zeschky, D. Wolf, M. Moser, I. Hilgendorf, C. Bode, A. Zirlik Germany 2.55 MICRORNA 143-145 DEFICIENCY IS ASSOCIATED WITH IMPAIRED VASCULAR FUNCTION Giuseppe Danilo Norata, C. Pinna, F. Zappella, L. Elia, G. Condorelli, A. Catapano Italy 2.56 CARDIOVASCULAR RISK IN YOUNG WOMEN WITH PREMATURE OVARIAN FAILURE AND SURGICAL MENOPAUSE Natalia Sharashkina, O. Tkacheva, N. Latysheva, I. Novikova, L. Butoreva Russia 2.57 CROSS-TALK OF HOMOCYST(E)INE AND THIOREDOXIN IN CORONARY ARTERY DISEASE Liangwei Zhong, Y. Wu, L. Yang China 2.58 ROLE OF PERI-RENAL FAT(PRF) IN ASSOCIATION WITH RISK FACTORS FOR ATHEROSCLEROSIS: A NEW METHODOLOGY. Leonardo Borges Roever, E.S. Resende, N.P. Silva, A.D. Debs, L.H. Resende, Atherosclerosis Brazil 2.59 Β2-GLYCOPROTEIN I ENHANCES ENDOTHELIAL NITRIC OXIDE SYNTHASE EXPRESSION AND NITRIC OXIDE GENERATION IN HUMAN AORTIC ENDOTHELIAL CELLS An-Na Chiang, W.C. Chiu, W.H.H. Sheu, S.Y. Lin Taiwan R.O.C. 2.60 CORRELATION BETWEEN SERUM PARAOXONASE AND HOMOCYSTEINE THIOLACTONASE ACTIVITY , ADIPOKINES AND ASYMMETRIC DIMETHYLARGININE LEVELS IN RENAL TRANSPLANT PATIENTS Lajos Locsey, I. Seres, F. Sztanek, L. Szabo, L. Asztalos, G. Paragh Hungary 2.61 3-HYDROXYKYNURENINE - A NEW FACTOR ASSOCIATED WITH CAROTID ATHEROSCLEROSIS, OXIDATIVE STRESS AND INFLAMMATION IN URAEMIA Dariusz Pawlak, M. Mysliwiec, K. Pawlak Poland 2.62 LEPTIN TRIGGERS DISTURBED CA2+ TRANSPORT IN MONOCYTES OF OVERWEIGHT PATIENTS János Tamás Padra, I. Seres, G. Fóris, Z. Balogh, G. Kónya, Z. Karányi, G. Paragh Hungary 76 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) CHLOROGENIC ACID REDUCE PLASMA LIPIDS AND INFLAMMATORY-RELATED GENE EXPRESSION IN HYPERLIPIDEMIC RABBITS Ya-Mei Yu, W.C. Chang Taiwan R.O.C. 2.64 IMPACT OF CIGARETTE SMOKE ON THE TRANSMIGRATION OF MONOCYTES THROUGH AN ENDOTHELIAL CELL LAYER Inka Gallitz, R. Janssens, K. Stolle, Y. Steffen, S. Wagner, S. Lebrun, M. Lietz Germany 2.65 INVOLVEMENT OF PROTEIN TYROSINE PHOSPHATASE HYPERHOMOCYSTEINEMIA AND HYPERCHOLESTEROLEMIA INDUCED VASCULAR ENDOTHELIAL DYSFUNCTION Saurabh Sharma, M. Singh, P.L. Sharma India 2.66 VASOPROTECTIVE ACTIVITY OF SUPRAMOLECULAR SUPEROXIDE DISMUTASE CHONDROITIN SULFATE - CATALASE CONJUGATE Alexander V. Maksimenko, A.V. Vavaev, E.G. Tischenko Russia 2.67 CELL PROLIFERATION IN DIFFERENT ATHEROSCLEROTIC LESIONS OF HUMAN ARTERIES Alexander N. Orekhov, E.R. Andreeva, I.V. Adrianova, Y.V. Bobryshev Russia, Australia 2.68 DISTRIBUTION OF HLA-DR-EXPRESSING CELLS IN THE INTIMA OF HUMAN AORTA: POSSIBLE ROLE IN SURVEILLANCE AND MAINTENANCE OF VASCULAR HOMEOSTASIS Yuri V. Bobryshev, M.M. Moisenovich, O.L. Pustovalova, I.I. Agapov, A.N. Orekhov Russia, Australia 2.69 RELATIONSHIP BETWEEN INSULIN SENSITIVITY AND LIPID PROFILE IN EUTHYROID TYPE 1 DIABETIC PATIENTS T. Bulum, L. Duvnjak, Ingrid Prkačin Croatia 2.70 ASSOCIATION BETWEEN EXTRACELLULAR MATRIX PROTEINS AND MATRIX METALLOPROTEINASE ACTIVITY IN PATIENTS WITH ATHEROSCLEROTIC AND NON-ATHEROSCLEROTIC THORACIC AORTIC ANEURYSMS Olga Irtyuga, I. Voronkina, L. Smagina, V. Uspensky, N. Tsoy, E. Shlyakhto, O. Moiseeva Russia 77 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.63 Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.71 PURE TOCOTRIENOL ISOMERS REDUCE PROTEIN AND GENE EXPRESSION OF LPS-INDUCED INFLAMMATION AND ENDOTHELIAL ACTIVATION IN ENDOTHELIAL CELLS S. Muid, G.R.A. Froemming, Hapizah Nawawi Malaysia 2.72 RELATIONSHIP BETWEEN ENDOTHELIAL AND RENAL FUNCTION IN PATIENTS WITH CHRONIC HEART FAILURE AND PRESERVED EJECTION FRACTION Olga Mytrokhina, O. Kuryata, A. Miroshnichenko Ukraine WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS 2.73 RECOMBINANT ANTI-PHOSPHORYLCHOLINE IGG ANTIBODIES PREVENT POST-INTERVENTIONAL ACCELERATED ATHEROSCLEROTIC VASCULAR REMODELING Mark M Ewing, S.A. Karabina, M. Nordzell, J.C. Karper, R. Atout, M.R. de Vries, D. Sexton, H. Lettesjö, I. Dahlbom, O. Camber, J. Frostegard, E. Ninio, J.W. Jukema, K. Pettersson, P.H. Quax The Netherlands, France 2.74 THE NOVEL SPLEEN TYROSIN KINASE INHIBITOR FOSTAMATINIB DISODIUM ATTENUATES INFLAMMATION AND ATHEROGENESIS IN LOW DENSITY LIPOPROTEIN RECEPTOR DEFICIENT MICE I. Hilgendorf, I. Remer, S. Eisele, K. Zeschky, C. Colberg, N. Hoppe, C. Bode, A. Zirlik, Florian Willecke Germany 2.75 COMPLEMENT FACTOR C5A MODULATES VEIN GRAFT REMODELING AND ACCELERATED ATHEROSCLEROSIS VIA INTERFERENCE IN MAST CELL ACTIVATION Margreet R. de Vries, A. Wezel, A. Schepers, J. Kuiper, I. Bot, P.H.A. Quax The Netherlands 2.76 INTERLEUKIN 15 PLAYS AN IMPORTANT ROLE IN ATHEROGENESIS IN APOLIPOPROTEIN E KNOCKOUT MICE Omid Dadoo, A. Ashkar, C. Richards, B. Trigatti Canada 78 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) 2.77 NUMERICAL AND FUNCTIONAL DEFECTS OF CIRCULATING DENDRITIC CELLS IN PATIENTS WITH CORONARY ARTERY DISEASE Ilse Van Brussel, E.A. Van Vré, G.R. De Meyer, C.J. Vrints, J.M. Bosmans, H. Bult Belgium 2.78 LOSS OF PHOSPHOINOSITIDE 3-KINASE GAMMA ACTIVITY LEADS TO DECREASED NEOINTIMA FORMATION AFTER VASCULAR INJURY IN MICE Natalia Smirnova, N. Malet, S. Gayral, A.-P. Gadeau, M. Wymann, L. Martinez, M. Laffargue France 2.79 LTB4 PATHWAY ACTIVATION: ONE OF THE MECHANISMS UNDERLYING EARLY ATHEROSCLEROSIS IN OBSTRUCTIVE SLEEP APNEA SYNDROME F. Stanke-Labesque, J.L. Pépin, T. de Jouvencel, C. Arnaud, J.P. Baguet, R. Tamisier, J.F. Jourdil, P. Lévy, Magnus Bäck France, Sweden 2.80 SELECTIVE DEPLETION OF T REGULATORY CELLS IMPACTS EXPERIMENTAL ATHEROSCLEROSIS PROGRESSION AND VLDL METABOLISM R. Klingenberg, N. Gerdes, Robert M. Badeau, D. Ketelhuth, M. Rudling, D. Strodthoff, S.K. Nilsson, K. Öörni, M. Jauhiainen, C. Lohmann, T. Lüscher, K. Lahl, T. Sparwasser, G.K. Hansson Sweden WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) 2.81 EVALUATION OF ENDOTHELIAL PROGENITOR CELLS AND MICROPARTICLES AFTER HIPOLIPEMIANT TREATMENT IN PATIENTS WIHT SUBCLINICAL ATHEROSCLEROSIS Carolina Nunes França, C.E.S. Ferreira, M.C.O. Izar, F.A. Helfenstein Fonseca Brazil 2.82 CORONARY-HEART DISEASE (CHD), PERIPHERAL-VASCULAR DISEASE (PVD) OR BOTH (C&PD): PROGNOSTIC IMPLICATIONS FOR RECURRENT EVENTS. THE AIRVAG COHORT EXTENDED FOLLOW-UP M.L. Peralta, C. Aranda, A.I. Huelmos, I. Gonzalez Anglada, E. Puras, B. Herreros, C. Sanchez, V. Castilla, L. Lopez Bescos, Carlos Guijarro, The AIRVAG Investigators Spain 79 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: MECHANISMS FOR THE PROGRESSION AND REGRESSION OF ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.83 VISFATIN AND HSCRP IN RELATION TO ABDOMINAL OBESITY IN MORBID OBESE SUBJECTS Zohreh Karbaschian, A. Golpaie, M.J. Hosseinzadeh-Attar, M. Hosseiny, M. Talebpor, N. Karbaschian Iran 2.84 THE ROLE OF EXTRACELLULAR HYALURONAN IN DEVELOPMENT OF ATHEROSCLEROSIS AND ENGINEERED BEE HYALURONIDASE AS A POTENTIAL TOOL FOR THE TREATMENT Brigitte Greiderer-Kleinlercher, A. Iliás, S. Reitinger, G. Lepperdinger Austria 2.85 RELATIONSHIPS BETWEEN BLOOD PRESSURE AND LIPID MARKERS OF ATHEROSCLEROSIS Elena Vitalyevna Pello, S.K. Malyutina, G.I. Simonova, Y.P. Nikitin Russia 2.86 OSTEOCALCIN AND METABOLIC SYNDROME Paloma Diez Romero, M.A.A. Rodriguez, C.D. Romero, I.C. Estevanez, C.L. Paredes, F.D. Serrano, M.T. Valdeperez, J.S.F. Rubio, J.M. Nuñez-Cortes Spain 2.87 EFFECTS OF QUINAPRIL AND TELMISARTAN ON MATRIX METALLOPROTEINASE-2 AND ITS TISSUE INHIBITOR IN PATIENTS WITH CAD UNDERWENT PTCA Vladimir Naumov, A. Partigulova, Y. Kosenkov, E. Orlova, V. Kuharchuk, V. Masenko Russia 2.88 ATHEROGENIC LIPID PROFILE AND DEVELOPMENT OF MULTIVESSEL CORONARY ARTERY DISEASE IN WOMEN Ryuhei Saito, Y. Kawai, M. Watanabe, A. Motoyama, R. Ishida, M. Kitayama, K. Kajinami Japan 2.89 RELATIONSHIP BETWEEN THE NUMBER OF STENOSED CORONARY ARTERIES AND RENAL FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE Nataliia Bardachenko, O. Kuryata, L. Bardachenko Ukraine 2.90 HUMAN PLASMA PHOSPHOLIPID TRANSFER PROTEIN (PLTP) EXPRESSION IN TRANSGENIC RABBITS IS PROATHEROGENIC David Masson, V. Deckert, T. Gautier, A. Klein, C. Desrumaux, C. Viglietta, J.P. Pais de Barros, N. Le Guern, J. Grober, J. Labbé, F. Ménétrier, P.J. Ripoll, M. Leroux-Coyau, G. Jolivet, L.M. Houdebine, L. Lagrost France 80 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) 2.91 INFLUENCE OF INDUCIBLE NITRIC OXIDE SYNTHASE IN THE DEVELOPMENT OF ANEURYSMS IN THE ABDOMINAL AORTA OF RATS: NEW EXPERIMENTAL MODEL Paula Prudente, K. Mata, E. Floriano, J. Junior, S. Ramos Brazil 2.92 IMPORTANT CYTOKINES AND CHEMOATTRACTANTS FOR VULNERABLE ATHEROSCLEROTIC PLAQUE AND ACUTE CORONARY SYNDROME. RESULTS OF ARTERIAL WALL AND BLOOD STUDIES Yulia I. Ragino, A.M. Chernjavski, Y.V. Polonskaja, A.M. Volkov, E.V. Kashtanova Russia 2.93 ANNEXIN A5 PREVENTS REACTIVE STENOSIS IN A DOSE-DEPENDENT FASHION: POTENTIAL FOR CLINICAL APPLICATION Mark M. Ewing, K. Pettersson, J.C. Karper, M.R. de Vries, M.L. Sampietro, J.W. Jukema, P.H. Quax The Netherlands 2.94 SILENCING OF SOCS-3 GENE DUE TO HYPERMETHYLATION INDUCED BY BOTH TNF-Α AND IGF-1 IN HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS Kajari Dhar, D. Pankajakshan, D.K. Agrawal USA 2.95 CHLAMYDIA PNEUMONIAE INFECTION IMPAIRS ENDOTHELIAL FUNCTION IN THE ABSENCE OF A HOST IMMUNE RESPONSE Justin Deniset, E. Dibrov, G. Pierce Canada 2.96 ATORVASTATIN SUPPRESS OXIDIZED LOW DENSITY LIPOPROTEIN-INDUCED DENDRITIC CELL-LIKE DIFFERENTIATION OF RAW264.7 CELLS BY INACTIVATION OF THE P38 MAPK PATHWAY L. Hu, Linghong Shen, S. Jin, D. Li, H. Xiao, P. Nie, J. Yi, B. He China 2.97 NEW THIAZOLIDINE-2,4-DIONES IMPROVE LIPID PROFILE AND DOW-REGULATE PRO-INFLAMMATORY GENE EXPRESSION IN LDL RECEPTOR-DEFICIENT MICE F.A. César, M. Rudnicki, C.A.I. Saito, S.L. Galdino, M.C.A. Lima, I.R. Pitta, Dulcineia Saes Parra Abdalla Brazil 2.98 REDUCED NUMBER OF DENDRITIC CELLS IN ATHEROSCLEROTIC PLAQUES OF UREMIC PATIENTS Daniel Neureiter, V. Campean, D. Wachter, A. Yilmaz, K. Amann Austria 2.99 5,6-SECOSTEROL AFFECTS MACROPHAGE DIVERSITY AND INDUCES PROINFLAMMATORY MACROPHAGE ACTIVATION Brigitta Buttari, E. Profumo, R. Monticolo, L. Iuliano, R. Businaro, R. Riganò Italy 81 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.100 CHARACTERIZATION OF T CELLS INFILTRATING PERIVASCULAR CORONARY ADIPOSE TISSUE IN ATHEROSCLEROSIS. Dominik Ludew, K. Urbanski, B. Kapelak, T. Mikolajczyk, R. Nosalski, R. Korbut, T.J. Guzik Poland 2.101 CD137 ON CD4+T LYMPHOCYTES IN PATIENTS WITH ACUTE CORONARY SYNDROME MIGHT BE A MARKER FOR VASCULAR SMOOTH MUSCLE CELL DEATH J.E. Park, J.Y. Lee, J.Y. Kim, B.S. Kwon, Bok Soo Lee Republic of Korea 2.102 MYCOPHENOLIC ACID HAS ANTI-INFLAMMATORY CAPACITY BY INHIBITION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 PRODUCTION IN VASCULAR SMOOTH MUSCLE CELLS Mirjam Schuchardt, M. Tölle, J. Prüfer, S. Huber, W. Zidek, M. van der Giet Germany 2.103 TRIGLYCERIDE METABOLISM AND INTERLEUKIN-6 LEVELS ARE ALTERED IN CARRIERS OF THE MINOR ALLELE OF AN INTERLEUKIN-1B GENE VARIATION (1473G/C) Javier Delgado-Lista, P. Perez-Martinez, A. Garcia-Rios, J. Solivera, E.M. Yubero-Serrano, F. Fuentes, L.D. Parnell, J. Shen, P. Gomez, Y. Jimenez-Gomez, M.J. Gomez-Luna, C. Marin, S.E. Belisle, F. Rodriguez-Cantalejo, S.N. Meydani, J.M. Ordovas, F. Perez-Jimenez, J. Lopez-Miranda Spain 2.104 MANNOSE BINDING LECTIN AS CARDIOVASCULAR RISK FACTOR: A COHORT STUDY Boudewijn Klop, A. Alipour, A. Westzaan, E. Birnie, G.J.M. van de Geijn, T. Njo, J.W. Janssen, N. van der Meulen, J.W.F. Elte, A.P. Rietveld, M. Castro Cabezas The Netherlands 2.105 ASSOCIATION OF PERIODONTAL DISEASE WITH ISCHEMIC STROKE: A CASECONTROL STUDY Masatsune Ogura, H. Iwabuchi, M. Ishihara, H. Sato, Y. Sato, R. Tsukinoki-Murakami, K. Matsushita Japan 2.106 ROLE OF ROSUVASTATIN AND CLOPIDOGREL ALONE AND COMBINED IN ENDOTHELIAL PROGENITOR CELLS AND ENDOTHELIAL MICROPARTICLES Carolina Nunes França, L.F.M. Pinheiro, M.C.O. Izar, F.A. Helfenstein Fonseca Brazil 2.107 THE ROLES OF CHOLESTEROL AND INFLAMMATION IN THE FORMATION AND PROGRESSION OF ATHEROSCLEROSIS Hong Seog Seog, E.J. Kim, H.J. Baek, J.O. Na, C.U. Choi, H.E. Lim, S.W. Rha, C.G. Parl, D.J. Oh, B.W. Yeom Republic of Korea 82 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) 2.108 CIRCULATING SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 AND TRANSFORMING GROWTH FACTOR-BETA-1 IN PATIENTS WITH RECURRENT ISCHEMIA AFTER CORONARY ARTERY BYPASS GRAFTING SURGERY Karina V. Korzhenevskaya, N.A. Gavrisheva, A.V. Panov, T.P. Ses, G.A. Alekseeva, M.Z. Alugishvili, I.T. Abesadze, N.L. Lohovinina Russia 2.109 INVOLVEMENT OF TOLL LIKE RECEPTOR-4 IN INFLAMMATORY RESPONSES OF ENDOTHELIAL CELLS R. Menghini, M. Tesauro, V. Rovella, A. Marino, R. Lauro, M. Federici, Carmine Cardillo Italy 2.110 ATHEROGENIC IN VIVO LDL OXIDATION, THROMBOXANE-MEDIATED PLATELET ACTIVATION AND SIMULTANEOUS OCCURRENCE OF NATURAL IMMUNITY IN ATHEROSCLEROSIS-PRONE (LDLR-/- AND APOE-/-) MICE Eiji Matsuura, L. Shen, Y. Matsunami, N. Quan, K. Kobayashi, Y. Shoenfeld, K. Oguma, L.R. Lopez Japan 2.111 AN APPROACH BASED ON LIPID NANOPARTICULES TO DETERMINE THE ROLE OF MONOCYTES/MACROPHAGES IN THE DEVELOPMENT OF AORTIC VALVE ATHEROSCLEROTIC LESIONS Manuela Calin, I. Manduteanu, E. Butoi, D. Stan, E. Dragan, A.M. Gan, M. Simionescu Romania 2.112 ADVANCED ABDOMINAL AORTIC ANEURYSMS DISPLAY A SPECIFIC INFLAMMATORY-PROATHEROSCLEROTIC PROFILE WITH RENAL DYSFUNCTION, RAISED D-DIMER, EXPANDED CD14++CD16+-MONOCYTES HAVING HIGH CD143 Chiara Barisione, G. Ghigliotti, D. Palombo, D. Palmieri, G. Spinella, B. Pane, P. Fabbi, P. Altieri, P. Spallarossa, C. Brunelli, S. Garibaldi Italy 2.113 THE ROLE OF NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) IN ANTIINFLAMMATORY AND ANTI-ATHEROSCLEROTIC ACTION OF NICOTINIC ACID IN MOUSE MODEL OF ACCELERATED ATHEROSCLEROSIS Łukasz Mateuszuk, M. Sternak, M. Gajda, M. Szafarz, J. Szymura-Oleksiak, M. Franczyk-Żarów, R. Kostogrys, S. Chłopicki Poland 2.114 EVALUATION OF A DIABETIC RABBIT MODEL FOR IN-STENT RESTENOSIS P. W. Radke, A. Joost, A. Kaiser, M. Basler, M. Mandapathil, C. Weber, S. Yla-Herttuala, W. Ito Germany 2.115 RELATIONSHIPS BETWEEN MARKERS OF APOPTOSIS AND ANTIBODIES TO OXIDIZED LOW-DENSITY LIPOPROTEINS IN PROGRESSING ATHEROSCLEROSIS Victor Gurevich, L. Vasina, N. Petrischev, A. Lugovaya Russia 83 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.116 THE DELETERIOUS INFLUENCE OF TENOFOVIR-BASED THERAPIES ON THE PROGRESSION OF ATHEROSCLEROSIS IN HIV-INFECTED PATIENTS Gerard Aragones, P. Pardo, R. Beltrán-Debón, A. Rull, L. Fernández-Sender, J. Joven, C. Alonso-Villaverde Spain 2.117 DUFFY BLOOD ALLOANTIGEN SYSTEM INFLUENCES INFLAMMATORY CHEMOKINE CONCENTRATION IN SERUM BUT NOT PLASMA: GEOGRAPHIC DIFFERENTIATION AS AN ADDITIONAL CONFOUNDING FACTOR María Barreda, G. Aragones, A. Rull, R. Beltrán-Debón, J. Camps, J. Joven Spain 2.118 PLASMA CHEMERIN IS ASSOCIATED WITH MARKERS OF INFLAMMATION AND CORONARY ARTERY DISEASE IN PATIENTS NOT ON ASPIRIN M. Herová, M. Schmid, Martin Hersberger Switzerland 2.119 CHANGES OF ENDOGLIN LEVELS IN SERUM AND MICE AORTA WITH RESPECT TO CHOLESTEROL AND ATORVASTATIN Lenka Večeřová, Z. Strasky, J. Rathouska, M. Slanarova, E. Brcakova, P. Nachtigal Czech Republic 2.120 THE EFFECT OF PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY UPON MMP2,MMP9,TIMP1 AND NOX1 RELEASE IN PATIENTS WITH STABLE ANGINA C. Revnic, C. Ginghina, A. Mereuta, D. Gradinaru, Floarea Revnic Romania 2.121 A SHORT-TERM HIGH COMPLEX-CARBOHYDRATE DIET REDUCES THE BASELINE INFLAMMATORY PROFILE Itzhak Shapira, O. Rogowski, S. Berliner, O. Raz Israel 2.122 EFFECTS OF INTENSIVE LIPID-LOWERING ON PLATELET ACTIVATION & MARKERS OF SYSTEMIC INFLAMMATION IN PATIENTS AT ELEVATED CARDIOVASCULAR RISK Eleanor Catherine Wicks, P. Maciocia, S. Bournazos, R. Hilling-Smith, I. Dransfield, N. Uren UK 2.123 ERK SIGNALING IS INVOLVED IN INFLAMMATION AND VASCULAR REMODELING PROCESS IN PREMATURE CORONARY ARTERY DISEASE Veena Dhawan, N. Mahajan, O.M. Bhat, A. Bahl, I. Sharma India 2.124 OXIDATIVE STRESS MEDIATES APL-INDUCED THROMBOSIS AND ATHEROSCLEROSIS DEVELOPMENT IN ANTIPHOSPHOLIPID SYNDROME P. Ruiz-Limón, C. Perez-Sanchez, M.A. Aguirre, N. Barbarroja, R.M. Carretero, A. Rodriguez-Ariza, E. Collantes-Estevez, J.M. Villalba, F. Velasco, M. Khamashta, M.J. Cuadrado, Chary Lopez-Pedrera Spain 84 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) 2.125 MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND PARAOXONASE-1 IN PERIPHERAL ARTERIAL DISEASE: A MODEL OF INTERACTION BETWEEN DEFENSE AGAINST OXIDATIVE STRESS AND INFLAMMATION Anna Rull, R. García, L. Fernández-Sender, R. Beltrán-Debón, G. Aragonès, J.M. Alegret, C. Alonso-Villaverde, M. Mackness, J. Camps, V. Martin-Paredero, J. Joven Spain 2.126 TAQIB AND I405V CETP POLYMORPHISMS DO NOT MODIFY PLASMA INFLAMMATORY MARKERS: A STUDY IN A BRAZILIAN POPULATION SAMPLE Eliane Soler Parra, F.L. D'Alexandri, N.B. Panzoldo, D.B. Kaplan, E.C. de Faria Brazil 2.127 SOLUBLE CELLULAR ADHESION MOLECULES, MYELOPEROXIDASE, AND NEOPTERIN IN METABOLIC SYNDROME PATIENTS WITH STABLE AND UNSTABLE ANGINA PECTORIS Peteris Tretjakovs, A. Jurka, I. Bormane, I. Mikelsone, D. Reihmane, G. Krievina, K. Elksne, J. Verbovenko, G. Bahs, D. Fuchs Latvia 2.128 ENDOGLIN-RELATED PATHWAYS ARE NOT RELATED TO DISTINCT PREDISPOSITION TO ATHEROSCLEROSIS IN C57BL/6J AND C3H/HEJ MICE Jana Rathouska, Z. Strasky, L. Vecerova, E. Brcakova, M. Slanarova, P. Nachtigal Czech Republic 2.129 CORRELATIONS BETWEEN CLINICAL, IMMUNOLOGICAL AND METABOLIC CONTRIBUTORS AND ATHEROSCLEROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS Enrico Ammirati, R. Contri, E. Bozzolo, S. Tramontana, K. Garlaschelli, A. Palini, D. Cianflone, A.L. Catapano, M.G. Sabbadini, G.D. Norata Italy 2.130 EZETIMIBE INHIBITS PMA-INDUCED MONOCYTIC DIFFERENTIATION INTO MACROPHAGE-LIKE PHENOTYPE THROUGH THE MICRORNA PATHWAY Paloma Muñoz-Pacheco, A. Ortega-Hernández, A. Fernández-Cruz, D. Gómez-Garre Spain 2.131 ATHEROSCLEROSIS RISK FACTORS, INFLAMMATION AND DENTAL STATE IN PATIENTS WITH CARDIO-CEREBROVASCULAR DISEASE AND EXCESSIVE OBESITY (BMI OVER 40) FROM ROMANIA Ioan Axente Gutiu, L.I. Gutiu, F.S. Radulescu Romania 2.132 ASSESSMENT OF INSULIN RESISTANCE, DYSLIPIDEMIA, OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN MALE PATIENTS WITH ANGIOGRAPHICALLY PROVEN CORONARY ARTERY DISEASE Binita Goswami, D. Tayal, S. Tyagi, V. Mallika India 85 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.133 ASSOCIATION BETWEEN INFLAMMATION AND ATHEROSCLEROSIS IN METABOLIC SYNDROME PATIENTS: THE SAME IN ALL ARTERIAL BEDS? Philipp Rein, C.H. Saely, S. Beer, A. Vonbank, C. Boehnel, V. Drexel, V. Kiene, H. Drexel Austria, Liechtenstein, USA 2.134 STATE CELLULAR LEVEL OF IMMUNE RESPONSE IN PATIENTS WITH CHD, DEPENDING ON THE AVAILABILITY OF SIMPLE OR COMPLEX CORONARY STENOSIS Oleksandr Lomakovskyi Ukraine 2.135 CARDIOVASCULAR RISK FACTORS AND INFLAMMATORY MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS: GENDER DIFFERENCES Tatiana A Panafidina, T.V. Popkova, N.G. Klukvina, D.S. Novikova, E.N. Alexandrova, Z.S. Alekberova, E.L. Nasonov Russia 2.136 ASSOCIATION OF TNF-ALPHA AND ANTICARDIOLIPIN ANTIBODIES IN TYPE II DIABETES MELLITUS Mirjana Becarevic, J. Seferovic, S. Ignjatovic, N. Majkic-Singh Serbia 2.137 DECREASED TITERS OF ANTI-OXLDL ANTIBODIES AFTER ACUTE CORONARY SYNDROME IN PATIENTS WITH METABOLIC SYNDROME ARE ASSOCIATED WITH SEVERITY OF ATHEROSCLEROSIS Henrique A Fonseca, C.M. Monteiro, L.F. Pinheiro, F.A. Fonseca, S.A. Brandao, S.C. Fischer, A.O. Santos, M.A. Gidlund, A.M. Monteiro, A.M. Figueiredo Neto, M. Izar Brazil 2.138 PERIODONTAL TREATMENT INDUCES REDUCTION RISK MARKERS FOR ATHEROSCLEROSIS Andrea Moreira Monteiro, M. Jardini, S. Alves, A. Figueiredo Neto, M. Gidlund Brazil 2.139 HLA-G AND NPC1L1 GENE POLYMORPHISMS IN CAD PATIENTS WITH DIFFERENT LEVELS OF LDL Chiara Boiocchi, E. Maggioli, S. Bozzini, M. Cuccia, C. Falcone Italy 2.140 CRYPTOCOCCUS NEOFORMANS CAUSES LIPID PEROXIDATION; THEREFORE IT IS A POTENTIAL INDUCER OF ATHEROGENESIS Connie Jarrstrand Hall, U. Dizcfalusy, K. Sandstedt, L.R. Bouhafs Sweden 86 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) Poster No 2.141 LEVELS OF ADHESION MOLECULES (S-ICAM-1 AND S-VCAM-1) IN DIFFERENT DEGREE OF ISCHEMIC CHRONIC HEART FAILURE: CORRELATION WITH HS-CRP Slavica Radovanovic, D. Popovic-Lisulov, N. Ninkovic, A. Djokovic, S. Hinic, M. Krotin, T. Simic, A. Savic-Radojevic Serbia 2.142 HIGH ENDOTHELIAL SHEAR STRESS INDUCES RUPTURE-PRONE PLAQUES FORMATION DUE TO ANGIOGENESIS Guixue Wang, J. Qiu, J. Hu, H. Liu, L. Ye, Y. Zheng, Y. Teng, D. Zhang China 2.143 18 FDG-PET IMAGING AND GENE EXPRESSION OF MARKERS OF NEOANGIOGENESIS, MICRO VESSEL DENSITY AND VULNERABILITY IN ATHEROSCLEROTIC HUMAN CAROTID PLAQUES Sune Folke Pedersen, M. Græbe, A.M.F. Hag, L. Højgaard, H. Sillesen, A. Kjær Denmark 2.144 THE INFLUENCE OF MYOCARDIAL REVASCULARIZATION ON ANGIOGENIC GROWTH FACTORS IN CORONARY ARTERY DISEASE PATIENTS Igor V. Sergienko, E.V. Merculov, A.E. Semenova, V.P. Masenko Russia WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) 2.145 MACROPHAGE SUBSETS VARY IN THEIR ASSOCIATION WITH PLAQUE STABILITY Heather Jean Medbury, J. Ngo, V. James, K. Hitos, A.K. Guiffre, J.P. Fletcher Australia 2.146 IMPORTANCE OF VIMENTIN IN FOAM-CELL FORMATION AND ATHEROGENESIS Jeanna Perman, J. Borén Sweden 2.147 LEUKOTIENE-INDUCED CALCIFICATION AND OSTEOGENIC DIFFERENTIATION OF HUMAN AORTIC VALVE INTERSTITIAL CELLS Edit Nagy, D.C. Andersson, G.K. Hansson, M. Bäck Sweden 87 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine WORKSHOP: HYPOXIA AND ANGIOGENESIS IN THE PLAQUE (contd.) Poster Session Poster Area WORKSHOP: CONSEQUENCES OF INFLAMMATION AND IMMUNE RESPONSE IN ATHEROSCLEROSIS (contd.) From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No 2.148 INTERLEUKIN-6 REGULATES LXRΑ-RESPONSIVE EXPRESSION OF ABCA1 AND ABCG1 VIA A JAK/STAT SIGNALING PATHWAY-DEPENDENT WAY Chao-Ke Tang, J. Xiao, K. Yin China 2.149 EFFECTS OF TACROLIMUS-ELUTING STENTS IN A DIABETIC RABBIT MODEL OF IN-STENT RESTENOSIS P. W. Radke, A. Joost, A. Kaiser, M. Mandapathil, M. Basler, S. Yla-Herttuala, C. Weber, W. Ito Germany, Finland 2.150 IMPACT OF ANTI-TNFALPHA THERAPY ON SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH PSORIATIC ARTHRITIS Massimo Puato, M. Zanardo, R. Ramonda, E. Faggin, M. Zanon, G. Balbi, A. Lo Nigro, M. Rattazzi, A. Doria, P. Pauletto Italy 2.151 THE AKITA-LDLR-/- MOUSE AS A MODEL OF DIABETIC ATHEROSCLEROSIS Daniel Engelbertsen, F. To, P. Dunér, O. Kotova, I. Söderberg, R. Alm, M. Gomez, J. Nilsson, E. Bengtsson Sweden 2.152 EFFECTOR MEMORY T LYMPHOCYTES ARE ASSOCIATED WITH CARDIOVASCULAR DISEASE IN HUMANS AND AORTIC ATHEROSCLEROSIS IN APOE AND LDL-R KNOCK-OUT ANIMALS. Giuseppe Norata, E. Ammirati E, M. Banfi, V. Vacchio, S. Tramontana, K. Garlaschelli, F. Pelegatta, L. Grigore, D. Cianflone, A. Maseri, A. Catapano, A. Palini Italy WORKSHOP: HYPOXIA AND ANGIOGENESIS IN THE PLAQUE (contd.) 2.153 IS HYPOXIA THE COMMON TRIGGER FOR INFLAMMATION AND APOPTOSIS IN HUMAN CAROTID ATHEROSCLEROTIC PLAQUES? Alessandra Bitto, G. De Caridi, F. Spinelli, F. Squadrito Italy 2.154 POLYPHENOLS FROM RED PROPOLIS SUPPRESSES ANGIOGENESIS BY INDUCING VON HIPPEL-LINDAU-DEPENDENT HIF-1 ALPHA DEGRADATION J.B. Daleprene, M. Rudnicki, T.P. Ong, M. Ikegaki, H. Menrad, T. Geis, T. Schmid, N. Dehne, B. Bruene, Dulcineia Saes Parra Abdalla Brazil 88 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: HYPOXIA AND ANGIOGENESIS IN THE PLAQUE (contd.) 2.155 INTRA-PLAQUE VESSEL DENSITY, INFLAMMATORY CELLS AND EXISTENCE OF THROMBIN-CLEAVED FORM OF OSTEOPONTIN ARE THE RISK FACTORS FOR SYMPTOMATIC STROKE Mie Kurata, T. Okura, Y. Kumon, H. Watanabe, M. Tagawa, J. Higaki, M. Nose Japan 2.156 THE ROLE OF PRENATAL CHRONIC HYPOXIA ON MYOCARDIAL ISCHEMIA / REPERFUSION INJURY IN ADULT RABBITS OFFSPRING Ziyang Huang, Z. Wang, J. Yang China 2.157 THE IMPORTANCE OF DE NOVO LIPOGENESIS OF LIPID LOADING IN HUMAN MACROPHAGES L. Mattsson Hultén, B. Liu, M. Levin, E. Lu, L. Håversen, C. Ullström, S.O. Olofsson, Lu Li Sweden 2.158 HYPOXIC CELLS ARE ABUNDANT IN MURINE ATHEROSCLEROTIC LESIONS Nanna Junker, E.D. Bartels, T.X. Pedersen, C. Christoffersen, L.B. Nielsen Denmark 2.159 HIGH MAST CELL NUMBERS IN HUMAN CAROTID ATHEROSCLEROTIC PLAQUES HAVE PREDICTIVE VALUE FOR FUTURE CARDIOVASCULAR EVENTS Sanne Willems, A. Vink, I. Hoefer, P. Quax, G. Pasterkamp The Netherlands WORKSHOP: NUCLEAR RECEPTORS AT THE CROSSROAD OF LIPID METABOLISM AND INFLAMMATION 2.160 THE TRANSCRIPTION FACTOR HNF-4Α: A KEY ACTOR OF THE INTESTINAL UPTAKE OF FATTY ACIDS IN MOUSE V. Frochot, M. Alqub, A.-L. Cattin, V. Carrière, A. Houiller, L. Barbot, S. Saint-Just, A. Ribeiro-Pillet, P. Cardot, J. Chambaz, M. Rousset, Jean-Marc Lacorte France 2.161 ROLES OF LXRΑ AND LXRΒ IN THE REGULATION OF INTESINAL CHOLESTEROL ABSORPTION: DISTINCTIVE EFFECTS ON BILE ACID METABOLISM IN MICE X. Hu, K. Steffensen, Z.Y. Jiang, P. Parini, J.Å. Gustafsson, M. Gåfvels, Gösta Eggertsen Sweden 89 From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine Poster No Poster Session Poster Area WORKSHOP: HYPOXIA AND ANGIOGENESIS IN THE PLAQUE (contd.) Poster No 2.162 FAR INFRA-RED THERAPY PROMOTES ISCHEMIA-INDUCED ANGIOGENESIS IN DIABETIC MICE AND RESTORES HIGH GLUCOSE-SUPPRESSED ENDOTHELIAL PROGENITOR CELL FUNCTIONS Shing-Jong Lin, P.H. Huang, J.W. Chen Taiwan R.O.C From the Vulnerable Plaque to the Vulnerable Patient– Challenges for Translational Medicine WORKSHOP: NUCLEAR RECEPTORS AT THE CROSSROAD OF LIPID METABOLISM AND INFLAMMATION (contd.) 2.163 PPARA GENE LEVEL DIFFERENTLY AFFECTS LIPID METABOLISM AND INFLAMMATION IN APOLIPOPROTEIN E2 KNOCK-IN MICE Fanny Lalloyer, K. Wouters, E. Vallez, J. Vanhoutte, M. Baron, R. Shiri-Sverdlov, M. Hofker, B. Staels, A. Tailleux France 2.164 ATHEROSCLEROTIC LESION REMODELLING IN REV-ERBΑ-DEFICIENT MICE Eric Bauge, C. Comte, C. Duhem, J. Vanhoutte, B. Staels, H. Duez France 2.165 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS REGULATE NADPH OXIDASE EXPRESSION AND FUNCTION IN HUMAN AORTIC SMOOTH MUSCLE CELLS Adrian Manea, S.A. Manea, I.M. Fenyo, M. Raicu Romania 90 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: THROMBOGENIC RISK FACTORS FOR ATHEROTHROMBOSIS AND ACUTE CORONARY EVENTS 3.01 NADPH OXIDASE-RELATED OXIDATIVE STRESS ENHANCES PLATELET THROMBOXANE PRODUCTION IN ASPIRIN-TREATED PATIENTS UNDERGOING ELECTIVE PERCUTANEOUS CORONARY INTERVENTION Pasquale Pignatelli, S. Basili, G. Tanzilli, S. Di Santo, R. Carnevale, D. Pastori, M. Schillizzi, C. Calabrese, E. Mangeri, P. Ferroni, F. Violi Italy 3.02 TIMING AND DOSE OF STATIN THERAPY DEFINE ITS IMPACT ON INFLAMMATORY AND ENDOTHELIAL RESPONSES DURING MYOCARDIAL INFARCTION Luiza Pego, S.N. Santos, E.C. Faria, D.S.P. Abdalla, A.A. Sousa Soares, A.V.T. Japiassú, J.C. Quinaglia e Silva, J.A.F. Ramires, O.R. Coelho, A.C. Sposito, on behalf of the Brasilia Heart Study Group Brazil 3.03 PITAVASTATIN PROVIDES CONSISTENT LONG-TERM HDL-CHOLESTEROL IMPROVEMENTS IN A RANGE OF PATIENTS WITH DYSLIPIDAEMIA: RESULTS FROM A PHASE III STUDY PROGRAMME Neil Hounslow UK 3.04 INCIDENCE OF CORONARY EVENTS AND CASE-FATALITY RATES IN RELATION TO CONCENTRATIONS OF BLOOD LEUKOCYTES Samuel Adamsson Eryd, J.G. Smith, O. Melander, B. Hedblad, G. Engström Sweden 3.05 THE CLASS II PHOSPHOINOSITIDE 3-KINASE ISOFORM Β REGULATES PLATELET FUNCTION AND ARTERIAL THROMBOSIS IN MICE Gianpaolo Tibolla, S.S. Barbieri, S. Gianellini, L. Arnaboldi, A. Corsini, E. Tremoli, M. Falasca, G.D. Norata, A.L. Catapano Italy 3.06 THE IMPACT OF LOW DENSITY LIPOPROTEIN RECEPTOR(LDLR) GENE MUTATION ON CAROTID INTIMA MEDIA THICKNESS, IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA Vasiliki Metaxa, C. Pitsavos, I. Skoumas, A. Miliou, E. Oikonomou, K. Aznaouridis, K. Masoura, C. Stefanadis Greece 3.07 THE INFLUENCE OF TF AND TFPI POLYMORPHISMS ON THROMBIN GENERATION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE Trine Baur Opstad, A.Å. Pettersen, V. Bratseth, H. Arnesen, I. Seljeflot, Center for Clinical Heart Research Norway 3.08 THE EFFECT OF STATIN TYPE ON THE ACTIVITY OF ANTIPLATELET THERAPY : POST-HOC ANALYSIS OF CILON-T TRIAL Jung Won Suh, M.J. Cha, S.P. Lee, H.S. Kim, CILON-T Investigators Republic of Korea 91 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: THROMBOGENIC RISK FACTORS FOR ATHEROTHROMBOSIS AND ACUTE CORONARY EVENTS (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.09 HOMOCYSTEINE LOWERING AND GLUTATHIONE INCREASING EFFECTS OF NACETYLCYSTEINE IN ACUTE CORONARY SYNDROME I. Squellerio, G. Marenzi, F. Veglia, G. Falcucci, L. Boccotti, S. Eligini, E. Tremoli, Viviana Cavalca Italy 3.10 THE SEX-RELATED DIFFERENCES IN ASSOCIATIONS BETWEEN ACTIVITY OF FIBRINOLYSIS AND SOME CARDIOVASCULAR DISEASES IN MOSCOW RESIDENTS AGED 55+ Victoria A Metelskaya, L.A. Ratnikova, S.A. Shalnova, M.A. Shkolnikova, A.D. Deev Russia 3.11 INFLUENCE OF DAILY ALCOHOL CONSUMPTION ON SERUM ADIPONECTIN LEVELS IN MEN Shinji Makita, A. Abiko, M. Nagai, M. Nakamura Japan 3.12 ERECTILE DYSFUNCTION AS A SUBROGATE MARKER OF CORONARY ARTERY DISEASE Antonio Hernández-Mijares, A. Jover, E. Solá, C. Bañuls, K. García-Malpartida, M. Rocha, V.M. Víctor Spain 3.13 CHANGING ROLE OF THE “CARDIOVASCULAR RISK FACTOR PROFILE” IN ACUTE MYOCARDIAL INFARCTION Rahul Potluri UK 3.14 VARYING PROPORTIONS OF PERIPHERAL VASCULAR DISEASE INTERVENTIONS COMPARED WITH CORONARY VASCULAR DISEASE IN ENGLAND.IMPLICATIONS FOR THE AETIOPATHOLOGY OF ATHEROSCLEROSIS? Naseer Ahmad, C. Chan UK 3.15 ASSOCIATION OF THROMBOMODULIN GENE VARIANTS IN INDIAN PATIENTS WITH CORONARY ARTERY DISEASE (CAD) Tester Ashavaid, S. Shah, C. Ponde, R. Rajani, R. Mankeshwar India 3.16 IDENTIFICATION OF HAEMATOLOGICAL MARKERS ASSOCIATED WITH POOR OUTCOME IN PATIENTS WITH ACUTE CORONARY SYNDROME Oona Merono, C. Garcia, M. Cladellas, L. Recasens, V. Bazan, N. Ribas, G. Rivas, A. Sainz, E. Valles, J. Bruguera Spain 92 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: THROMBOGENIC RISK FACTORS FOR ATHEROTHROMBOSIS AND ACUTE CORONARY EVENTS (contd.) 3.17 REVERSIBLE MYOCARDIAL DYSFUNCTION AND LEFT VENTRICULAR DILATATION IN ACUTE MYOCARDIAL INFARCTION Anis Alavy Lutfullaevich, S. Kenjaev Rashidovich, M. Kenjaev Latipovich Uzbekistan 3.18 THE DECREASE OF MEAN PLATELET VOLUME AFTER EXTRACORPOREAL LDLCHOLESTEROL ELIMINATION IN PATIENTS WITH SEVERE FAMILIAL HYPERCHOLESTEROLEMIA M. Blaha, M. Lanska, Vladimir Blaha, I. Fatorova Czech Republic 3.19 PREVALENCE AND PROGNOSTIC FACTORS OF ANAEMIA IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Ioannis Kanonidis, G. Rompolas, K. Martiadou, C. Kagiadaki, G. Dadoush, G. Sakantamis Greece 3.20 DYSLIPIDAEMIA AND ITS COMPONENTS: PREVALENCE IN HEALTH CARE PROFESSIONALS AND IN THE REST OF THE WORKING POPULATION Pedro Valdivielso-Felices, E. Calvo-Bonacho, C. Catalina-Romero, M.Á. Sánchez-Chaparro, J.C. Sainz-Gutierrez, I. Romero-Mateos, L. Palacio-Olmos, M. Gálvez-Godoy, J.A. Gelpi-Méndez, L.M. Ruilope-Urioste Spain 3.21 PARAMETERS OF PLATELETS ACTIVATION AND METABOLISM OF CARDIOMYOCYTES IN ACUTE MYOCARDIAL INFARCTION. Alicja Polek, W. Sobiczewski, J. Matowicka-Karna Poland 3.22 ENDOTHELIAL DERIVATIVES AS THE POSSIBLE PREDICTORS OF THE CARDIOVASCULAR RISK IN RHEUMATOID ARTHRITIS PATIENTS (RA) WITH HYPERCHOLESTEROLEMIA Robert Rupinski, E. Walewska, A. Filipowicz-Sosnowska, P. Gluszko Poland 3.23 BACK TO THE FUTURE IN TREATMENT OF REFRACTORY NO-REFLOW AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION: INTRACORONARY EPINEPHRINE Tolga Aksu, A. Colak, M. Durukan, U. Guray, H. Kısacık Turkey 3.24 EFFECT OF QUERCETIN ON THE DYNAMICS OF THE LEVEL OF NT-PROBNP IN PATIENTS WITH ACUTE CORONARY SYNDROME Anis Alavy Lutfullaevich, S. Varisxanova, S. Kenjaev Uzbekistan 93 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.25 HIGH SERUM TESTOSTERONE IS ASSOCIATED WITH REDUCED RISK OF CARDIOVASCULAR EVENTS IN ELDERLY MEN C. Ohlsson, E. Barrett-Connor, S. Bhasin, E. Orwoll, F. Labrie, M.K. Karlsson, Ö. Ljunggren, L. Vandenput, D. Mellström, Åsa Tivesten Sweden 3.26 C-REACTIVE PROTEIN (CRP) AND LIPID LEVELS TO PREDICT THE RISK OF CORONARY HEART DISEASE IN STATIN-TREATED STABLE CORONARY PATIENTS Benoit J Arsenault, S.M. Boekholdt, P. Deedwania, D.A. DeMicco, W.H. Bao, G.M. Preston, D.D. Waters, J.C. LaRosa, P. Barter, J.J.P. Kastelein, the Treating to New Targets (TNT) Investigators The Netherlands 3.27 PREVALENCE OF ELEVATED C-REACTIVE PROTEIN LEVELS IN A PRIMARY CVD PREVENTION POPULATION IN EUROPE: THE EURIKA STUDY Julian Halcox, J.R. Banegas, J. Dallongeville, G.D. Backer, E. Guallar, E.L. Massó-González, J. Perk, F. Rodriguez Artalejo, P.G. Steg, F. Tubach, C. Borghi UK 3.28 DEVELOPMENT OF A NOVEL HOMOGENEOUS ASSAY FOR REMNANT LIKE PARTICLE CHOLESTEROL Yasuki Ito, Y. Hirao Japan 3.29 RELATION OF CENTRAL AND BRACHIAL BLOOD PRESSURE TO LEFT VENTRICULAR HYPERTROPHY. THE CZECH POST-MONICA STUDY Peter Wohlfahrt, D. Wichterle, J. Seidlerová, J. Filipovský, J. Bruthans, V. Adámková, R. Cífková Czech Republic 3.30 APOLIPOPROTEIN M (APOM) - A NOVEL BIOMARKER FOR ACUTE KIDNEY INJURY Eva Martha Madsen Svarrer, H.Ø. Andersen, M. Helvind, M.C.J. Slagman, G. Navis, R.P.F. Dullaart, B. Dahlbäck, L.B. Nielsen Denmark 3.31 TARGETED PHOSPHOLIPID METABOLITE PROFILING IN THE CLINICAL LABORATORY USING MALDI-QIT-TOF-MS/MS Gerald Stübiger, E. Aldover-Macasaet, W. Bicker, K. Pock, V. Bochkov, K. Widhalm, O. Belgacem Austria 94 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) Poster No 3.32 EFFICACY BIOMARKER FOR PCSK9 INHIBITORS Reijo Laaksonen, K. Koistinen, R. Huuhilo, K. Tarasov, R. Hurme, K. Ekroos, A. Prat, N. Seidah, M. Jänis Finland 3.33 THE IMPACT OF PERCUTANEOUS CORONARY INTERVENTION(PCI) WITH STENT IMPLANTATION UPON MMP9 AND INFLAMATORY MARKERS IN PATIENTS WITH ACUTE CORONARY SYNDROMES Floarea Revnic, C.R. Revnic, C. Ginghina, A. Mereuta, D. Gradinaru, G. Prada, S. Prada, C. Pena, C. Borsa, C. Ionescu Romania 3.34 ACUTE CORONARY SYNDROME AND LOW-HDL CHOLESTEROL. RELATIONSHIP WITH LIPOPROTEIN (A) R. Toro, P. Gomez, C. Rodriguez, I. Tinoco, D. Biedma, M. Virseda, Alipio Mangas Spain 3.35 IP-10 AND ACUTE MYOCARDIAL INFARCTION Ali Esmaeili Nadimi Iran 3.36 COLLAGEN MATRIX OF ATHEROSCLEROTIC PLAQUE AND LIPID SPECTRUM IN PATIENTS WITH MYOCARDIAL INFARCTION TREATED WITH ROZUVASTATIN DEPENDING ON REVASCULARIZATION METHOD Natalya A Koziolova, E. Malgina Russia 3.37 GLYCAEMIC CONTROL AND SECONDARY PREVENTION TREATMENT IN POSTINFARCTION PATIENTS REDUCE THE INTENSITY OF CARDIOVASCULAR RISK FACTORS CORRELATION Eleonora Vataman, S. Filimon, D. Lisii, O. Priscu, A. Grivenco Moldova 3.38 CLINICAL AND ECONOMIC IMPACT OF ANTITHROMBOTIC MANAGEMENT PATTERNS IN ACUTE CORONARY SYNDROMES: RATIONALE AND DESIGN OF THE EPICOR STUDY H. Bueno, F. Van de Werf, N. Danchin, M. Tafalla, C. Bernaud, L. Annemans Belgium 95 Genetics, Risk Factors and Epidemiology- from Population to Patients WORKSHOP: THROMBOGENIC RISK FACTORS FOR ATHEROTHROMBOSIS AND ACUTE CORONARY EVENTS (contd.) Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.39 MOLECULAR INSIGHTS INTO CARDIOMYOCYTE APOPTOSIS: TREATMENT WITH PIOGLITAZONE IN LOW-DOSE STREPTOZOTOCIN AND HIGH FAT DIET FED OBESITY IN MURINE MODEL Uma Bhandari, V. Kumar, C.D. Tripathi, G. Khanna, C. Hemantkumar, K.K. Pillai India 3.40 DEVELOPMENT OF A NOVEL HOMOGENEOUS ASSAY FOR SMALL HDL Maiko Higuchi, T. Hirano, Y. Ito Japan 3.41 ROLE OF MITOCHONDRIAL DNA DAMAGE IN ATHEROSCLEROSIS John Mercer, L. Hurst, M. Bennett UK 3.42 CIRCULATING CD4+CD25+FOXP3+ REGULATORY T CELLS DO NOT PREDICT RISK FOR ACUTE CARDIOVASCULAR EVENTS Maria Wigren, H. Björkbacka, B. Hedblad, G.N. Fredrikson, J. Nilsson Sweden 3.43 INFLAMMATION-SENSITIVE PROTEINS AND RISK OF ATRIAL FIBRILLATION: A POPULATION-BASED COHORT STUDY Samuel Adamsson Eryd, J.G. Smith, O. Melander, G. Engström, B. Hedblad Sweden 3.44 DECREASED PLASMA LEVELS OF SRAGE ARE ASSOCIATED TO CORONARY FIBRO-LIPIDIC WALL VOLUME IN PATIENTS WITH PROVEN OR SUSPECTED CAD Giuseppina Basta, S. Del Turco, T. Navarra, A. Mazzarisi, F. Cocci, M. Coceani, M. Bianchi, M. Schlueter, P. Marraccini Italy 3.45 ASSOCIATION OF BLOOD ACTIVE MATRIX METALLOPROTEINASE-3 WITH CAROTID PLAQUE SCORE IN MALE FROM A COMMUNITY POPULATION IN TAIWAN Li-Ming Lien, Y.C. Hsieh, C.H. Bai, W.H. Chen, H.C. Chiu, F.I. Hsieh, K.G. Shyu, H.Y. Chiou Taiwan R.O.C. 3.46 ASSOCIATION OF COPY NUMBER VARIATIONS AND SINGLE NUCLEOTIDE POLYMORPHISMS IN METALLOTHIONEIN GENES WITH PATHOGENESIS OF DIABETES AND CORONARY ARTERY DISEASE Rahila Kozarova, A. Postadzhiyan, B. Finkov, M. Apostolova Bulgaria 3.47 SMALL ARTERIES DILATION AND ENDOTHELIAL MARKERS IN CARDIOVASCULAR RISK PATIENTS Gemma Aragonès, R. Ferré, J. Girona, N. Plana, J. Merino, M. Heras, L. Masana Spain 96 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) 3.48 THE RELATIONSHIP BETWEEN HDL-CHOLESTEROL AND HDL FUNCTION Lauren Wade, M. Widdowson, A. Mcgown, J. Gibney, F. Thies, A. Mcginty, I. Young, J. McEneny UK 3.49 THE IMPACT OF PLASMA ADIPOCYTE FATTY ACID-BINDING PROTEIN ON RENAL INSUFFICIENCY AND CORONARY LESION SEVERITY IN DIABETIC PATIENTS Toru Miyoshi, M. Doi, K. Takeda, S. Usui, K. Nakamura, S. Kusachi, K. Kusano, H. Ito Japan 3.50 EVALUATION OF SERA BIOMARKERS FOR CORONARY ARTERY DISEASE AND DIABETES Nadya Ivanova, A. Postadzhiyan, B. Finkov, M. Apostolova Bulgaria 3.51 ASSOCIATION OF ANGIOTENSIN II TYPE 1 RECEPTOR +1166 A/C GENE POLYMORPHISM WITH HUMAN CAROTID PLAQUE VULNERABILITY Ana Kolakovic, M. Zivkovic, D. Radak, I. Koncar, T. Djuric, L. Davidovic, D. Alavantic, A. Stankovic Serbia 3.52 INCREASED PREGNANCY ASSOCIATED PROTEIN A (PAPP-A) PREDICTED EARLY SURVIVAL IN CHRONIC HEMODIALYSIS (HD) PATIENTS Vladimir Blaha, E. Mistrik, S. Dusilova-Sulkova, M. Kalousova, C. Andrys, M. Blaha, L. Sobotka Czech Republic 3.53 A COMPARISON OF SERUM ANDROGENS IN PRE-ECLAMPTIC AND NORMOTESIVE PREGNANT WOMEN DURING THE THIRD TRIMESTER OF PREGNANCY Maryam Kashanian, F. Sharifzadeh, F. Fatemi Iran 3.54 SIGNIFICANT LABORATORY BIOCHEMICAL BIOMARKERS FOR CORONARY ATHEROSCLEROSIS AND ITS COMPLICATION Yulia I. Ragino, A.M. Chernjavski, Y.V. Polonskaja, N.V. Eremenko, M.V. Ivanova, E.V. Kashtanova Russia 3.55 COMPARISON OF THE VARIOUS LIPID RATIOS AND INDICES FOR RISK ASSESSMENT IN PATIENTS OF MYOCARDIAL INFARCTION Binita Goswami, M. Rajappa, B. Singh, S. Kumar, V. Mallika India 3.56 PITAVASTATIN REDUCES ELEVATED SOLUBLE LECTIN-LIKE OXIDIZED LDL RECEPTOR-1 LEVELS IN SUBJECTS WITH HYPERCHOLESTEROLEMIA: SUBANALYSIS OF KISHIMEN MULTICENTER PROSPECTIVE STUDY Noriaki Kume, Y. Fujioka, A. Taniguchi, S. Kagimoto, Y. Nakamura, T. Yamamoto, S. Fujimoto, Y. Hamamoto, K.I. Hirata, H. Koshiyama, KISHIMEN Investigators Japan 97 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.57 VITAMIN D DEFICIENCY AND ANAEMIA IN OVERWEIGHT/OBESE SUBJECTS Christina Katsagoni, A. Evangelopoulos, A. Giotopoulou, M. Bonou, N. Vallianou, V. Bountziouka, P. Avgerinos, E. Vogiatzakis, J. Barbetseas, D.B. Panagiotakos Greece 3.58 NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN URINE CONCENTRATIONS MAY SERVE AS AN EARLY PROGNOSTIC MARKER FOR ACUTE KIDNEY INJURY IN MYOCARDIAL INFARCTION PATIENTS Dimitrios Tziakas, G. Chalikias, C. Tsigalou, S. Apostolakis, D. Stakos, A. Thomaidi, K. Mitrousi, P. Kikas, P. Kriki, T. Gioka, S. Panagoutsos, V. Vargemezis, S. Konstantinides Greece 3.59 BASIC EVALUATION AND CLINICAL APPLICATION OF BLOOD LIPIDS MEASUREMENT USING A POINT OF CARE TESTING AMONG JAPANESE Norio Tada, K. Ito, Y. Tomono, H. Yoshida, S. Hoshina Japan 3.60 RELATIONSHIP BETWEEN LYMPHOCYTE CASPASE-3 ACTIVITY AND ATHEROSCLEROTIC PLAQUE VULNERABILITY Tatjana Ristic, V. Cosic, P. Vlahovic, M. Deljanin Ilic, V. Djordjevic Serbia 3.61 SERUM THIOREDOXIN ACTIVITY IS NEGATIVELY ASSOCIATED WITH TOTAL HOMOCYSTEINE LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE Wu Yunfei, L. Yang, Z. Liangwei China 3.62 THE EFFECT OF ROSUVASTATIN TREATMENT ON D-DIMER LEVELS IN OBESE PATIENTS WITH PRIMARY DYSLIPIDEMIA Dimitris I. Agapakis, C. Savopoulos, K. Tziomalos, E.V. Massa, N. Katsiki, E. Satsoglou, A.I. Hatzitolios Greece 3.63 THE LINK BETWEEN CARDIAC AUTONOMIC FUNCTION AND MARKERS OF OXIDATIVE STRESS IN CORONAY ARTERY DISEASE (CAD) Slavica Radovanovic, L. Stojanovic, M. Zdravkovic, M. Krotin, B. Milovanovic Serbia 3.64 ISCHEMIA MODIFIED ALBUMIN (ΙΜΑ) IN POSTMENOPAUSAL WOMEN WITH OR WITHOUT CORONARY ARTERY DISEASE (CAD) IN RELATION TO BMI AND OGTT K. Kazanis, M. Dalamaga, E. Kassi, G. Merantzi, I. Vagionas, G. Jullien, Amalia Dionyssiou –Asteriou Greece 3.65 DISORDERS OF PURINE METABOLISM ENZYMES IN ATHEROSCLEROSIS Slavica Kundalic, B. Kundalic, T. Ristic, D. Stankovic-Ferlez Serbia 98 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) 3.66 PREDICTIVE VALUE OF INFLAMMATORY MARKERS ON CARDIOVASCULAR EVENTS IN PATIENTS WITH CHRONIC HEART FAILURE Slavica Radovanovic, L. Stojanovic, M. Krotin, A. Djokovic, A. Savic-Radojevic, S. V Dragan, T. Simic Serbia 3.67 A COMPARISON BETWEEN INSULIN RESISTANCE SCORES PARAMETERS IN IDENTIFYING METABOLIC SYNDROME (MS) PATIENTS Angela Cozma, A.V. Sitar-Taut, D. Pop, D.T. Zdrenghea Romania 3.68 ASSOCIATION OF SCLEROSTIN SERUM LEVELS WITH THE SEVERITY OF AORTIC VALVE CALCIFICATION Ralf Koos, A.H. Mahnken, N. Marx, V. Brandenburg Germany 3.69 PLASMA VISFATIN CONCENTRATION IS A MARKER OF AN ATHEROGENIC METABOLIC PROFILE Theodosios Filippatos, V. Tsimihodimos, C.S. Derdemezis, I.F. Gazi, V. Saougos, A.D. Tselepis, M.S. Elisaf Greece 3.70 CHARACTERISTICS AND PREDICTIVE BIOMARKERS OF IN-STENT RESTENOSIS WITHIN DRUG-ELUTING STENTS Sang-Hyun Kim, H.L. Lee, J.B. Seo, W.Y. Chung, J.H. Zo, H.S. Ahn, M.A. Kim Republic of Korea 3.71 GRAFT STENOSIS IS ASSOCIATED WITH LIPOPROTEIN(A) C REACTIVE PROTEIN AND PLASMINOGEN ACTIVATOR INHIBITOR-1 IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS SURGERY Syed Shahid Habib, A.G.M. Abdel Gader, M.I. Kurdi, Z.A. Aseri Saudi Arabia 3.72 HIGH HEART RATE AS A RISK FACTOR FOR INCREASED ATHEROSCLEROSIS IN CORONARY ARTERY DISEASE(CAD)PATIENTS, STRONGLY RELATED TO NEW CARDIOVASCULAR EVENTS S. Radovanovic, Aleksandra Djokovic, D. Simic, I. Zivanovic, S. Jelic, M. Krotin Serbia 3.73 ENDOTHELIAL PROGENITOR CELL MOBILIZATION IS ENHANCED IN HIGH PREFORMANCE ATHLETES Maria Cristina Izar, C.R. Bittencourt, C.N. Franca, H.R. Fonseca, H.T. Bianco, V.L. Schwerz, F.A. Fonseca Brazil 99 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.74 CIRCULATING MICRORNAS: POTENTIAL BIOMARKERS IN ARTHEROSCLEROSIS Dwi Setyowati Karolina, A. Armugam, K. Jeyaseelan Singapore 3.75 FACIAL WRINKLES, GREY HAIR AND BALDNESS PREDICT RISK OF ISCHEMIC HEART DISEASE AND ISCHEMIC CEREBROVASCULAR DISEASE INDEPENDENT OF CHRONOLOGICAL AGE Mette Christoffersen, R. Frikke-Schmidt, P. Schnohr, G.B. Jensen, B.G. Nordestgaard, A. Tybjærg-Hansen Denmark 3.76 FABP4 PREDICTS ATHEROGENIC DYSLIPIDEMIA DEVELOPMENT. THE PREDIMED STUDY A. Cabré, N. Babio, I. Lazaro, M. Bulló, A. Garcia-Arellano, Lluís Masana, J. Salas-Salvadó Spain 3.77 THE APPLICATION OF RESEQUENCING MICROARRAY IN THE SCREENING OF FAMILIAL HYPERCHOLESTEROLEMIA Min-Ji Charng, K.R. Chiou Taiwan R.O.C. 3.78 ASSOCIATION OF ANTIBODY AGAINST HEAT SHOCK PROTEIN-27 AND PROOXIDANT-ANTIOXIDANT BALANCE WITH THE SEVERITY OF CORONARY ARTERY DISEASE AND METABOLIC SYNDROME Majid Ghayour-Mobarhan, H. Pourghadamyari, M. Moohebati, S.M.R. Parizadeh, S. Tavallaie, A. Sahebkar, A. Rahsepar, R. Paydar, G. Ferns Iran 3.79 ARTIFICIAL NEURAL NETWORK SYSTEM PREDICTS 6-YEAR INCIDENCE OF METABOLIC SYNDROME USING SERUM MARKERS FOR ATHEROSCLEROSIS Hiroshi Hirose, T. Takayama, S. Hozawa, I. Saito Japan 3.80 BIOMARKERS OF INFLAMMATION AND OXIDATIVE STRESS INDEPENTLY PREDICT THE PROGRESSION OF SUBCLINICAL ATHEROSCLEROSIS Douwe J. Mulder, J.D. Lefrandt, E. Tremoli, D. Baldassarre, A.J. Smit, on behalf of the IMPROVE Study Group The Netherlands 100 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) 3.81 PLASMA 1-DEOXYSPHINGOID BASES AS BIOMARKERS IN METABOLIC SYNDROME Alaa Othman, M.F. Rütti, A. von Eckardstein, T. Hornemann Switzerland 3.82 LIPOPROTEIN(A) IS AN INDEPENDENT RISK FACTOR FOR RECURRENT CORONARY EVENTS IN CHD PATIENTS Marat Ezhov, M. Safarova, O. Afanasieva, A. Lyakishev, S. Pokrovsky Russia 3.83 ANEMIA AND IRON DEPLETION INDEPENDENTLY ASSOCIATED WITH ANGIOGRAPHIC CORONARY ARTERY DISEASE. (THE LUDWIGSHAFEN RISK AND CARDIOVASCULAR HEALTH STUDY) Tanja Grammer, G. Silbernagel, S. Pilz, M. Kleber, A. Tomaschitz, B. Boehm, B. Winkelmann, W. Maerz Germany 3.84 PERIPHERAL ARTERIAL DIASESE AND TYPE 2 DIABETES MELLITUS: ROLE OF INFLAMMATORY AND HEMATOLOGICAL PARAMETERS J. Mancera, J. Rioja, M.A. Sánchez-Chaparro, T. Moreno, M.R. Sánchez-Pérez, M.J. Ariza-Corbo, P. González-Santos, Pedro Valdivielso Spain 3.85 HIGH LIPOPROTEIN (A) IN CHILDREN OF PATIENTS WITH PREMATURE CORONARY HEART DISEASE. RELATION TO OWN AND PARENTAL RISK FACTORS Michael Konnov, L. Dobordzhginidze, A. Deev, N. Gratsiansky Russia 3.86 ETHNIC DIFFERENCES IN CIRCULATING MARKERS OF ANGIOGENESIS AND THEIR ASSOCIATION WITH CARDIOVASCULAR RISK FACTORS AND PERIPHERAL ARTERIAL DISEASE Philip Christopher Bennett, S.H. Silverman, P.S. Gill, A.D. Blann, G.Y. Lip UK 3.87 BIOMARKERS ASSOCIATED WITH LONG TERM CARDIOVASCULAR EVENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Henrique Tria Bianco, M.C. Izar, T. Helfenstein, H.R. Fonseca, S.C. Fischer, C.E. Ferreira, S.P. Barbosa, R.M. Povoa, F.A. Fonseca, Gold Investigators Brazil 3.88 LOW ANKLE-BRACHIAL INDEX IS ASSOCIATED WITH CHRONIC KIDNEY DISEASE Peter Wohlfahrt, J. Bruthans, V. Adámková, R. Cífková, The Czech post-MONICA Czech Republic 3.89 SMALL DENSE LDL-CHOLESTEROL IS SUPERIOR TO LDL-CHOLESTEROL FOR DETERMINING SEVERE CORONARY ATHEROSCLEROSIS Y Meguro, Y. Ito, S. Koba, Y. Yokota, T. Hirano, Y. Ban, F. Tsunoda, T. Sato, M. Shoji, H. Suzuki, E. Geshi, Y. Kobayashi, T. Katagiri Japan 101 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.90 FENOFIBRATE REDUCES C-REACTIVE PROTEIN IN NON-OBESE HYPERTRIGLYCERIDEMIC PATIENTS WITH HIGH RISKS Chee Jeong Kim, M.A. Kim Republic of Korea 3.91 CORRELATION OF THE LEPTIN:ADIPONECTIN RATIO WITH INSULIN RESISTANCERELATED FACTORS IN JAPANESE MEN Yukio Ikeda, N. Hisakawa, T. Ohguro, Y. Kumon Japan 3.92 PLASMA AMINOTHIOL PROFILE IN APPARENTLY HEALTHY SUBJECTS FROM THE AZORES ARCHIPELAGO, PORTUGAL Maria Leonor Pavão, A. Lima, R. Ferin, J. Baptista Portugal 3.93 DIFFERENTIAL INDICATORS ASSOCIATED WITH SUBCLINICAL CORONARY ATHEROSCLEROSIS IN SUBJECTS WITH OR WITHOUT METABOLIC SYNDROME T.Y. Chiu, C.I. Chern, S.Y. Chen, C.C. Soon, Jaw-Wen Chen Taiwan R.O.C. 3.94 EFFECT OF CYCLOOXYGENASE-1 POLYMORPHISMS ON URINARY 11DEHYDROTHROMBOXANE B2 LEVELS IN PATIENTS UNDERGOING STENT IMPLANTATION PRETREATED WITH ASPIRIN Gustavs Latkovskis, N. Licis, B. Krivmane, E. Liepins, M. Dambrova, I. Urtane, A. Knipse, M. Zabunova, M. Berzina, A. Erglis Latvia 3.95 RAPID AND EFFICIENT IMMUNOCHROMATOGRAPHIC FATTY ACID BINDING PROTEIN ASSAY FOR EARLY DIAGNOSIS OF MYOCARDIAL INFARCTION Mikhail Voevoda, V. Shulman, L. Polikarpov, O. Shtegman, K. Nikolaev Russia 3.96 THE IMPORTANCE OF INFLAMMATORY MARKERS FOR EARLY DIAGNOSTIC IN ADOLESCENTS WITH METABOLIC DISEASES Vasile Negrean, M. Adam, T. Alexescu, S. Tarmure, F. Tomesc, D. Sturzu, A. Nemes Romania WORKSHOP: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFE STYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE 3.97 INFLAMMATION AND CARDIOVASCULAR FITNESS IS GENDER AND BODY MASS INDEX DEPENDENT Itzhak Shapira, O. Rogowski, S. Berliner Israel 102 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFE STYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE (contd.) 3.98 A 12-WEEK CIRCUIT RESISTANCE PROGRAM IMPROVED ANTIOXIDANT ENZYME ACTIVITY IN YOUNG ADULTS WITH DOWN SYNDROME Francisco Javier Ordonez, I. Rosety, A. Camacho-Molina, M.A. Rosety, M. Rosety, G. Fornieles, N. Garcia, M. Rosety-Rodriguez, A.J. Diaz-Ordonez Spain 3.99 INCREASING INTENSITIES OF LEISURE-TIME PHYSICAL ACTIVITY ARE ASSOCIATED WITH LOWER LEVELS OF C-REACTIVE PROTEIN IN HEALTHY 58YEAR OLD MEN Caroline Schmidt, G. Bergström Sweden 3.100 WALKING THERAPY FOR PATIENTS WITH DIABETES MELLITUS AND PERIPHERAL ARTERIAL DISEASE WHO ARE LIMITED BY LEG PAIN AND/OR FATIGUE Tracie Collins USA 3.101 OBJECTIVELY MEASURED DAILY PHYSICAL ACTIVITY RELATED TO BODY FAT IN YOUNG CHILDREN Magnus Dencker, O. Thorsson, M.K. Karlsson, C. Lindén, L.B. Andersen Sweden 3.102 THE EFFECT OF AEROBIC EXERCISE TRAINING ON ENDOTHELIN-1 CONCENTRATION IN OLD WOMEN Vahdat Boghrabadi, S. Nejatpour, A. Baghi Iran 3.103 DEMANDS AND HEART RATE VARIABILITY IN DANISH WHITE-COLLAR WORKERS Nanna Eller, M. Blønd, M. Nielsen, J. Kristiansen, B. Netterstrøm Denmark 3.104 COST EFFICACY IN HOSPITALIZED PATIENTS WITH DIABETES IS RELATIVE TO TREATMENT DECISION MAKING AND CLINICAL OUTCOME Christina Voulgari, S. Paximadas, N. Tentolouris Greece 3.105 LOW BONE MINERAL DENSITY IS NOT ASSOCIATED WITH CORONARY ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES Stefan Beer, C.H. Saely, G. Hoefle, A. Vonbank, P. Rein, A. Muendlein, H. Drexel Austria, Liechtenstein 3.106 IMPACT OF ACCULTURATION ON CORONARY ARTERY DISEASE IN THE SOUTH ASIAN IMMIGRANTS- UNIQUE POPULATION WITH INCREASED RISK Sunita Dodani, L. Dong USA 103 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFE STYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.107 LIVING ALONE AND PERMANENT DISABILITY ARE ASSOCIATED WITH POOR PROGNOSIS AFTER ELECTIVE PCI O. Shakhmatova, Andrew Komarov, E. Panchenko Russia 3.108 TOTAL BODY FAT AND ABDOMINAL FAT RELATED TO COMPOSITE RISK FACTOR SCORE FOR CVD IN YOUNGER CHILDREN Magnus Dencker, O. Thorsson, M.K. Karlsson, C. Lindén, P. Wollmer, L.B. Andersen Sweden 3.109 BODY MASS INDEX AND WAIST CIRCUMFERENCE AS PREDICTORS OF THE INCIDENCE OF TYPE 2 DIABETES AMONG ANGIOGRAPHIED CORONARY PATIENTS Christoph H. Saely, P. Rein, A. Vonbank, S. Beer, C. Boehnel, S. Greber, H. Drexel Austria, Liechtenstein 3.110 SYMPATHETIC OUTFLOW TO BONE MARROW MEGAKARYOCYTES STIMULATES NEOINTIMA FORMATION VIA PLATELET-DERIVED NEUROPEPTIDE Y Ken Abe, S. Saadat, J. Fennessy, S. Dandamudi, J. Kitlinska, J. Tilan, C. Lu, M.K. Hellerstein, Z. Zukowska USA 3.111 SHORT ENDURANCE TRAINING PROGRAM IMPROVED ENDOTHELIAL DYSFUNCTION IN DIABETIC FATTY RATS Ignacio Rosety, F. Ordonez, M. Rosety-Rodriguez, A. Camacho-Molina, A. Diaz-Ordonez, G. Fornieles, N. Garcia, M. Rosety, M.A. Rosety Spain 3.112 ASSOCIATION BETWEEN PHYSICAL EXERCISE AND SUBCLINICAL CORONARY ATHEROSCLEROSIS - RESULTS OF THE HEINZ NIXDORF RECALL STUDY Silke Andrich, N. Dragano, S. Möhlenkamp, U. Slomiany, U. Roggenbuck, J. Siegrist, K.H. Jöckel, R. Erbel, S. Moebus Germany 3.113 INFLUENCE OF TRAUMA LIFE-THREATENING ON LIPID METABOLISM Natalia Klyueva, A. Denisenko, T. Avaliani, O. Fedotova, A. Pshenichnaya, S. Tsikunov Russia 3.114 INFLUENCE OF DEPRESSION ON THE RISK OF CARDIOVASCULAR DISEASES AT MEN AGED 25-64 DURING 14 YEARS IN RUSSIA Valery Gafarov, E. Gromova, A. Gafarova, I. Gagulin Russia 3.115 ROLE OF FAMILY MILIEU IN TOBACCO ADDICTION A. Aggarwal, Shridhar Dwivedi, N. Singh India 3.116 PROINFLAMMATION STATUS IN DEPRESSION AND ISCHEMIC HEART DISEASE Rudolf Poledne, A. Pilipcincova, M. Bobak, H. Pikhart, P. Stavek, J. Pitha Czech Republic 104 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFE STYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE (contd.) 3.117 THE PARAOXONASE POLYMORPHISMS (PON1 LEU55MET AND GLN192ARG; PON2 SER311CYS) ARE NOT RELATED TO ACUTE MYOCARDIAL INFARCTION IN THE TUNISIAN POPULATION Sounira Mehri, M. Hammami Tunisia 3.118 SOME POPULATIONAL PECULIARITIES OF ATHEROSCLEROSIS IN SIBERIA Yuri Nikitin, G. Simonova, S. Malyutina Russia 3.119 CVD SCREENING IN A FAITH BASED SETTING IMPROVES ACCESS Devaki Nair, A. Jain, J.W. Persaud, D. Harvey, L. Robertson, D.P. Mikhailidis UK 3.120 SLEEP QUALITY: RISK FOR DEVELOPING TYPE 2 DIABETES? D.B. Araujo, A. Bertolami, Y. Nakamura, H.P. Zatz, A.A. Faludi, Marcelo Bertolami Brazil 3.121 TYPE 2 DIABETES AND THE PROGRESSION OF VISUALIZED ATHEROSCLEROSIS TO CLINICAL CARDIOVASCULAR EVENTS C.H. Saely, P. Rein, A. Vonbank, K. Huber, Heinz Drexel Austria, Liechtenstein, USA 3.122 YOUTH WHOSE PARENTS SMOKED HAVE REDUCED FLOW-MEDIATED DILATATION AS YOUNG ADULTS M. Juonala, Costan G. Magnussen, A. Venn, J.S.A. Viikari, T. Dwyer, O.T. Raitakari Australia 3.123 ECCENTRIC ENDURANCE EXERCISE ECONOMICALLY IMPROVES GLUCOSE TOLERANCE Markus Zeppetzauer, C.H. Saely, P. Rein, A. Vonbank, H. Drexel Austria 3.124 EFFECT OF BODY MASS INDEX ON ISCHAEMIC HEART DISEASE RISK: OBSERVATIONAL AND CAUSAL ESTIMATES ON 76000 INDIVIDUALS Børge G Nordestgard, T.M. Palmer, M. Benn, J. Zacho, A. Tybjærg-Hansen, G. Davey Smith, N.J. Timpson Denmark 105 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFE STYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.125 EFFECT OF AN ADHERENCE PROGRAMME ON CARDIOVASCULAR EVENTS IN HIGH-RISK PATIENTS WITH HYPERCHOLESTEROLEMIA Jacqueline Müller-Nordhorn, H. Englert, K. Wegscheider, H. Völler, F. Sonntag, W. Meyer-Sabellek, E. Windler, H.A. Katus, S.N. Willich Germany 3.126 EFFECTS OF TREADMILL TRAINING ON WALKING DISTANCE AND ENDOTHELIAL FUNCTION IN PATIENTS WITH INTERMITTENT CLAUDICATION Rafał Adam Januszek, P. Mika, A. Konik, R. Nowobilski, R. Niżankowski, A. Szczeklik Poland 3.127 WAIST CIRCUNFERENCE AND VASCULAR ALTERATIONS IN YOUNG MEN R. Toro, D. Biedma, P. Gomez, I. Tinoco, C. Rodriguez, M. Virseda, Alipio Mangas Spain 3.128 THE RELATIONSHIP BETWEEN JOB STRESS AND DYSLIPIDEMIA Pedro Valdivielso, C. Catalina-Romero, A. González-Quintela, M.Á. Sánchez-Chaparro, J.C. Sainz-Gutiérrez, C. Sanz-Martín, F. Gutiérrez-González, E. Calvo, L.M. Ruilope Spain WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) 3.129 RED CELL DISTRIBUTION WIDTH AND INCIDENCE OF HEART FAILURE: A POPULATION-BASED COHORT STUDY Yan Borné, J.G. Smith, O. Melander, B. Hedblad, G. Engström Sweden WORKSHOP: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFE STYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE (contd.) 3.130 PREVALENCE OF DIABETES AND OF IMPAIRED GLUCOSE TOLERANCE IN PATIENTS WITH ATHEROSCLEROSIS: THE IMPORTANCE OF THE INVOLVED ARTERIAL BEDS Christoph H Saely, P. Rein, S. Beer , A. Vonbank, C. Boehnel, V. Jankovic, V. Drexel, V. Kiene, H. Drexel Austria, Liechtenstein, USA 106 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: PSYCHOSOCIAL, SOCIOECONOMIC AND LIFE STYLE FACTORS AS DETERMINANTS OF CARDIOVASCULAR DISEASE (contd.) 3.131 HIGH PREVALENCE OF IMPAIRED GLUCOSE METABOLISM IN OVERWEIGHT PATIENTS WITH PERIPHERAL ARTERIAL DISEASE P. Rein, J. Ortmann, C.H. Saely, S. Beer, A. Vonbank, Christian Boehnel, H. Drexel, I. Baumgartner Austria, Liechtenstein 3.132 PERSONAL ANXIETY AND RISK DEVELOPMENT OF CARDIOVASCULAR DISEASES AT POPULATION MEN 25-64 YEAR OLD DURING 24 YEARS (WHO “MONICA”) V. Gafarov, Elena Gromova, A. Gafarova, I. Gagulin Russia 3.133 IMPACT OF CIGARETTE SMOKING ON SERUM LIPIDS IN TYPE 1 DIABETES MELLITUS T. Bulum, L. Duvnjak, Ingrid Prkačin Croatia 3.134 PREVALENCE OF SEVERE PVD IN A HIGH-RISK URBAN POPULATION RECEIVING SELF-EXPANDING NITINOL (SUPERA) STENTS Jayanth Koneru, A. Samuel, A. Hamdan, F. Shamoon, M. Bikkina USA 3.135 METABOLIC ALTERATIONS RELATED TO THE INCREASED RISK FOR DIABETES IN A GROUP OF MEXICAN OBESE NON-DIABETIC WOMEN Jorge L Ble-Castillo, E. Lopez-Juarez, A.M. Nolasco-Coleman, R. Cordova-Uscanga, I.E. Juarez-Rojop, C. Cervantes-Toache, J.C. Diaz-Zagoya, M.A. Juarez-Oropeza Mexico 3.136 INTERPLAY BETWEEN NITRIC OXIDE AND SUPEROXIDE ANION RADICAL DURING PROGRESSIVE EXERCISE IN ELITE SOCCER PLAYERS M. Zlatkovic, V. Jakovljevic, O. Stanojlovic, Dragan Djuric Serbia 3.137 LIFESTYLE BEHAVIOR AND CARDIOVASCULAR RISK IN HYPERCHOLESTEROLEMIA: IMPACT OF CONSUMPTION OF PHYTOSTEROLSUPPLEMENTED YOGURT Lluís Masana, O. Descamps, E. Bosi, F.A. Allaert, M.J. Chapman, E. Bruckert Spain 3.138 OBJECTIVELY MEASURED PHYSICAL ACTIVITY RELATED TO COMPOSITE RISK FACTOR SCORE FOR CVD IN CHILDREN Magnus Dencker, O. Thorsson, M.K. Karlsson, C. Lindén, P. Wollmer, L.B. Andersen Sweden 107 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.139 INTERACTIONS OF T-786C POLYMORPHISM OF ENOS GENE WITH ATORVASTATIN ON PARAMETERS OF LIPID METABOLISM IN BRAZILIAN ADULTS Vanessa Helena de Souz Zago, J.E. Tanus-Santos, M.R.G. Danelon, R.M.M. da Silva, E.C. de Faria Brazil 3.140 ATHEROGENIC SUBFRACTIONAL BLOOD LIPOPROTEINS PROFILE AND ITS GENETIC MARKERS IN WEST SIBERIA Elena Shakhtshneider, Y. Ragino, Y. Polonskaya, E. Kashtanova, I. Kulikov, M. Voevoda Russia 3.141 MIR-21, MIR-210, MIR-34A, MIR-146A AND MIR-146B-5P ARE UP-REGULATED IN HUMAN ATHEROSCLEROTIC PLAQUES Emma Kristiina Raitoharju, L.P. Lyytikäinen, M. Levula, N. Oksala, A. Mennander, R. Laaksonen, T. Lehtimäki Finland 3.142 THE M62I GENE POLYMORPHISM IN P-SELECTIN GLYCOPROTEIN LIGAND (PSGL-1) WITH CAROTID ATHEROSCLEROSIS: A PRELIMINAR STUDY Ana Kolakovic, I. Koncar, O. Stančic, L. Davidovic, D. Alavantic, A. Stankovic, M. Zivkovic Serbia 3.143 LPLCHIP®, A NOVEL MOLECULAR DIAGNOSTICS TOOL FOR THE IDENTIFICATION OF MUTATIONS IN THE LPL GENE R. Rodrigues, M. Artieda, J. Räty, T. Ritsema, Diego Tejedor, A. Martínez Spain 3.144 CC GENOTYPE OF THE ANGIOTENSIN II TYPE I RECEPTOR GENE PREDICTS ACUTE MYOCARDIAL INFARCTION IN A TUNISIAN COHORT Sounira Mehri, S. Mahjoub, A. Zaroui, R. Mechmeche, B. Baudin, M. Hammami Tunisia 3.145 ASSOCIATION OF POLYMORPHIC MARKERS C3386A OF HMGCR GENE AND G(-198)A OF FDFT1 GENE WITH CORONARY ARTERY DISEASE Alexey Nikolaevich Brovkin, K.A. Blagodatskikh, D.A. Zateyshchikov, L.O. Minushkina, A.G. Nikitin, V.V. Nosikov Russia 3.146 GENETIC EVIDENCE THAT LIPOPROTEIN(A) CAUSES ATHEROSCLEROSIS RATHER THAN THROMBOSIS P.R. Kamstrup, A. Tybjærg-Hansen, Børge G. Nordestgaard Denmark 108 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? (contd.) 3.147 IN VITRO FUNCTIONAL CHARACTERIZATION OF NOVEL AMINO ACID SUBSTITUTIONS IN PCSK9 FOUND IN HYPOCHOLESTEROLEMIC SUBJECTS Elisa Pinotti, E. Di Leo, C. Valenti, B. Cefalù, D. Noto, D. Norata, A. Catapano, M. Averna, P. Tarugi Italy 3.148 FAMILIAL HYPERCHOLESTEROLEMIA IN MEXICO. AN APPROXIMATION TO THE MUTATIONAL DIVERSITY. Gerardo Vaca, A. Vàzquez, T. Magaña, L. Ramìrez, I. Dàvalos, B. Marìn, E. Martìnez, G. Carrillo Mexico 3.149 MUTATION SPECTRUM IN THE LDL RECEPTOR GENE IN PATIENTS FROM THE SOUTH-EASTERN PART OF POLAND Malgorzata Walus-Miarka, B. Idzior-Walus, M. Sanak, B. Katra, M. Malecki, J. Starzyk, M. Wojcik, S. Dziedzina Poland 3.150 NOVEL RARE VARIANTS OF APOA5 GENE IN PATIENTS WITH SEVERE HYPERTRIGLYCERIDEMIA. Livia Pisciotta, R. Fresa, V. Guido, A. Bellocchio, S. Calandra, S. Bertolini Italy 3.151 NOVEL MUTATIONS IN SAR1B AND MTP GENES IN CHYLOMICRON RETENTION DISEASE AND ABETALIPOPROTEINEMIA Tatiana Fancello, M. Najah, A.L. Magnolo, A. Jelassi, E. Di Leo, N. Slimene, P. Tarugi Italy 3.152 CORRELATION OF GENETIC VARIATIONS OF GENES INVOLVED IN LOW HIGH DENSITY LIPOPROTEINS CHOLESTEROL SYNTHESIS IN INDIANS Tester Ashavaid, A. Sawant, R. Mankeshwar India 109 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.153 COMBINING EXOME SEQUENCING WITH EXCLUSION LINKAGE ANALYSIS AS A TOOL TO UNRAVEL THE MOLECULAR BASIS OF A COMMON GENETIC DISEASE Mohammad Mahdi Motazacker, R. Huijgen, J. Peter, J.C. Defesche, J.J.P. Kastelein, G.K. Hovingh, S. Kathiresan, N. Zelcer, S.W. Fouchier The Netherlands, USA 3.154 REGULATION AND FUNCTIONAL ANALYSIS OF MRAS Jennifer Freyer, E. Alcolak, J.F.P. Berbeè, M. Behrensen, Z. Aherrahrou, P. Linsel-Nitschke, J.J. Zwaginga, H. Schunkert, J. Erdmann Germany 3.155 A MULTIGENIC MODEL TO PREDICT RISK OF ISCHEMIC STROKE IN SUBJECTS WITH TYPE 2 DIABETES Roberto Pola, C.H. Kimber, I. Giarretta, A. Doney, A.M. Morris, E. Gaetani, C.N. Palmer Italy, USA 3.156 ABC TRANSPORTER GENES AND RISK OF TYPE 2 DIABETES Jesper Schou, A. Tybjærg-Hansen, B.G. Nordestgaard, R. Frikke-Schmidt Denmark 3.157 APOLIPOPROTEIN E GENE MUTATIONS IN SUBJECTS WITH MIXED HYPERLIPOPROTEINEMIA AND A CLINICAL DIAGNOSIS OF FAMILIAL COMBINED HYPERLIPIDEMIA M. Solanas-Barca, I. de Castro-Orós, A.M. Bea, M. Cofán, N. Plana, E. Ros, L. Masana, M. Pocoví, F. Civeira, Ana Cenarro Spain 3.158 HYPOALPHA-HYPOBETALIPOPROTEINEMIA (FAMILIAL COMBINED HYPOLIPIDEMIA) CAUSED BY LOSS OF FUNCTION MUTATIONS OF ANGPTL3 GENE Livia Pisciotta, E. Di Leo, P. Tarugi, R. Fresa, I. Zavaroni, D. Ardigò, S. Bertolini, S. Calandra Italy 3.159 ASSOCIATION OF DIABETES-MELLITUS-RELATED GENETIC VARIANTS WITH CORONARY ARTERY CALCIFICATION Sonali Pechlivanis, A. Scherag, T.W. Mühleisen, S. Möhlenkamp, R. Erbel, K.H. Jöckel, M.M. Nöthen, S. Moebus, Heinz Nixdorf Recall Study Group Germany 3.160 ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE (ALCAM) AND PROGNOSIS IN ACUTE ISCHEMIC STROKE Linda Merete Smedbakken, J.K. Jensen, J. Hallén, D. Atar, J.L. Januzzi, B. Halvorsen, P. Aukrust, T. Ueland Norway 110 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? (contd.) 3.161 DEVELOPMENT OF GENDER PRESPECIFIED PREDICTION MODEL BASED ON BAYESIAN BELIEVE NETWORKS METHOD FOR RISK ESTIMATION AFTER ACUTE CORONARY SYNDROME Marina A Evdokimova, I.V. Uporov, I.N. Kurochkin, A.V. Sulimov, D.N. Vtyurina, V.V. Nosikov, D.A. Zateyshchikov Russia 3.162 OVEREXPRESSION OF Β2-GLYCOPROTEIN I THAT INHIBITS CELL MIGRATION IN HUMAN AORTIC ENDOTHELIAL CELLS Wen-Chin Chiu, W.H.H. Sheu, S.Y. Lin, A.N. Chiang Taiwan R.O.C. 3.163 THE PREVALENCE OF POLYMORPHISMS PROTROMBOGENIC FACTORS IN PATIENTS WITH CORONARY HEART DISEASE Galina Alexandrovna Chumakova, A.A. Kozarenko, N. Veselovskaya Russia 3.164 FATTY ACID BINDING PROTEIN 4 AS A BIOMARKER OF CAROTID ATHEROSCLEROSIS AND OUTCOME IN PATIENTS WITH ACUTE ISCHEMIC STROKE Sverre Holm, T. Ueland, T.B. Dahl, A.E. Michelsen, M. Skjelland, D. Russell, K. Krogh-Sørensen, O.P. Clausen, D. Atar, J.L. Januzzi, P. Aukrust, J.K. Jensen, B. Halvorsen Norway 3.165 GENOME ANALYSIS IS MORE EFFFECTIVE THAN SINGLE-GENE ANALYSIS IN IDENTIFYING SUBJECTS AT HIGH RISK FOR ATHEROTHROMBOSIS Alberto Izzotti Italy 3.166 RISK IMPACT OF 12 PRIOR GWAS CANDIDATE GENES/LOCI FOR CORONARY ARTERY DISEASES IN THE GENETIC ISOLATED NEWFOUNDLAND AND LABRADOR POPULATION Ya-Gang Xie, J. Cui, E. Randell, J. Renouf, S. Li, A. Pope, S. Sun, W. Gulliver, B. Sussex, F.Y. Han Canada 3.167 DAXX AS A NOVEL TARGET IN THE PREVENTION OF ATHEROSCLEROSIS Duanfang Liao, Q. Tuo, G. Xu, B. Su, Q. He, B. Zhu China 3.168 KV1.5 MODULATES OXLDL-INDUCED ENDOTHELIAL INJURY VIA MITOCHONDRIAL ROS Guan-Lei Wang, Y.Y. Guan, W.L. Chen China 111 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.169 GENETIC VARIANTS ASSOCIATED WITH PRIMARY HYPERTRIGLYCERIDEMIA María Solanas-Barca, E. Jarauta, P. Martín-Fuentes, M. Cofán, E. Ros, L. Masana, N. Plana, A. Cenarro, F. Civeira Spain 3.170 A POLYMORPHISM IN THE HEART SPECIFIC FATTY ACID TRANSPORT PROTEIN 6 IS ASSOCIATED WITH THE METABOLIC SYNDROME AND CARDIOVASCULAR DISEASE Annegret Auinger, U. Helwig, D. Rubin, M. de Vrese, M. Lüdde, T. Rausche, N. Elmoktari, N. Frey, J. Schrezenmeir Germany 3.171 GENETIC PREDISPOSITION AND ADHERENCE TO THE MEDITERRANEAN DIET IN CORONARY ARTERY DISEASE George Vassileios Dedoussis, E.V. Theodoraki, T. Nikopensius, J. Suhorutńenko, M. Yannakoulia, M. Dimitriou, V. Peppes, G. Kolovou, N. Zakopoulos, A. Metspalu Greece 3.172 CHILHOOD-ONSET CHYLOMICRONEMIA WITH REDUCED PLASMA LPL ACTIVITY AND MASS: IDENTIFICATION OF A NOVEL GPIHBP1 MUTATION Joelle Magne, I. Coca-Prieto, O. Kroupa, P. Gonzalez-Santos, G. Olivecrona, E. Ehrenborg, P. Valdivielso Sweden 3.173 DO THE DIFFERENT NUMBER OF CA REPEATS IN P1 PROMOTER OF IGF1 GENE MAY INFLUENCED PLASMA IGF1 LEVELS? Pawel Burchardt, A. Gozdzicka-Jozefiak, W. Nowak, T. Siminiak Poland 3.174 THE TRP719ARG VARIANT OF KIF6 AND CARDIOVASCULAR OUTCOMES IN STATIN-TREATED, CORONARY STABLE PATIENTS OF THE TNT AND IDEAL PROSPECTIVE STUDIES Benoit J Arsenault, S.M. Boekholdt, G.K. Hovingh, C.L. Hyde, D.A. DeMicco, A. Chatterjee, P. Barter, P. Deedwania, D.D. Waters, J.C. LaRosa, T.R. Pedersen, J.J.P. Kastelein, the Treating to New Targets (TNT) and the Incremental Decrease in End Points Through Aggressive Lipid-Lowering (IDEAL) Investigators The Netherlands 3.175 HIGH-DOSE ATORVASTATIN REDUCES APOLIPOPROTEIN E CONCENTRATION SIGNIFICANTLY AND THIS IS INFLUENCED BY THE APOLIPOPROTEIN E GENOTYPE Yifen Liu, H. Soran, V. Charlton-Menys, D. Bhatnagar, M. Rutter, S. Kwok, M. France, P. Durrington UK 112 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? (contd.) 3.176 APOA5 -1131 T>C POLYMORPHISM IS A DETERMINANT OF TRIGLYCERIDE LEVELS IN THE SOUTH ASIAN POPULATION Elizabeth A Hughes, J.V. Patel, P. Gill, J. Chackathayil, G.Y. Lip UK 3.177 SELECTED GENES POLYMORPHISMS AND ATHEROSCLEROTIC CHANGES DEVELOPMENT IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Katarzyna Fischer, A. Walecka, L. Ostanek, M. Ostanek, M. Sawicki, A. Bińczak-Kuleta, A. Ciechanowicz, M. Brzosko Poland 3.178 EVALUATION OF THE ASSOCIATION BETWEEN COMMON VARIANTS AT THE GCK, GCKR, MTNR1B, AND G6PC2 LOCI WITH ANGIOGRAPHICALLY CHARACTERIZED CORONARY ATHEROSCLEROSIS Axel Muendlein, C.H. Saely, N. Stark, K. Geiger, S. Geller-Rhomberg, P. Rein, A. Vonbank, H. Drexel Austria, Liechtenstein 3.179 ANTIRETROVIRAL TREATMENT-INDUCED DYSLIPIDEMIA IN HIV-INFECTED PATIENTS IS INFLUENCED BY THE APOC3-RELATED RS10892151 POLYMORPHISM Raúl Beltrán-Debón, G. Aragones, C. Alonso-Villaverde, A. Rull, E. Rodríguez, P. Pardo, J. Camps, J. Joven Spain 3.180 PHARMACOGENETICS OF STATIN TREATMENT EFFICACY: ANALYSIS OF GENETIC VARIATION AT EIGHT CANDIDATE GENE LOCI Michal Vrablik, J. Hubacek, V. Adamkova, M. Prusikova, L. Zlatohlavek, V. Lanska, R. Ceska Czech Republic 3.181 DIFFERENTIAL PERIPHERAL-BLOOD GENE EXPRESSION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND STABLE CORONARY DISEASE Sagi Nahum, Y. Drier, N. Avidan, E. Domani, E. Sprecher, D. Aronson Israel 3.182 HIGH FREQUENCY OF NPY POLYMORPHISM IN IRAN AND ITS ASSOCIATION WITH CORONARY ARTERY DISEASE Ali Masoudi Kazemabad, M. Ghayour Mobarhan, K. Jamialahmadi, M. Moohebati, M. Mojarrad, R. Dehghan manshadi, M.M. Forghanifard Iran 3.183 AHSG GENE POLYMORPHISM AFFECTS PLASMA LEVELS OF NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN CAUCASIANS Pavel Suchanek, J.A. Hubacek, I. Kralova Lesna, V. Adamkova Czech Republic 113 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? (contd.) Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No 3.184 GENDER DEPENDENT ASSOCIATION BETWEEN KIF6 POLYMORPHISM AND RISK OF UNFAVORABLE OUTCOME IN PATIENTS SURVIVED ACUTE CORONARY SYNDROME O.S. Koroleva, M.A. Evdokimova, A.A. Pushkov, K.A. Blagodatskich, V.V. Nosikov, Dmitry A. Zateyshchikov Russia 3.185 RENIN-ANGIOTENSIN SYSTEM AND ACUTE MYOCARDIAL INFARCTION IN TUNISIAN POPULATION S. Mehri, Mohamed Hammami Tunisia 3.186 THE MTRR GG GENOTYPE IS ASSOCIATED WITH RESTENOSIS AFTER ELECTIVE PCI Olga Shakhmatova, A. Komarov, E. Panchenko Russia 3.187 ASSOCIATION BETWEEN THE PRO198LEU POLYMORPHISM IN THE GLUTATHIONE PEROXIDASE 1 (GPX1) GENE AND MYOCARDIAL INFARCTION IN A TUNISIAN POPULATION Riadh Jemaa, A. Kallel, Y. Sediri, H. Khorchfi, M. Feki, S. Abdessalem, M.S. Mourali, R. Mechmeche, N. Kaabachi Tunisia 3.188 EFFECT OF APOLIPOPROTEIN E GENOTYPES ON THE EFFICACY OF EZETIMIBE MONOTHERAPY IN PATIENTS WITH STATIN INTOLERANCE Mariann Harangi, I. Seres, G. Béke, I. Balogh, J. Harangi, T. Köbling, G. Paragh Hungary 3.189 POLYMORPHIC MARKERS OF THBD AND PROC GENES AND GENETIC PREDISPOSITION TO UNFAVOURABLE OUTCOMES IN PATIENTS AFTER ACUTE CORONARY SYNDROME Alexander Alekseevich Pushkov, K.A. Blagodatskikh, A.G. Nikitin, M.A. Evdokimova, D.A. Zateyshchikov, V.V. Nosikov Russia 3.190 NPC1L1 GENE POLYMORPHISMS AFFECTING CHOLESTEROL ABSORPTION Tomomi Maeda, M. Numakura, Y. Mashimo, N. Yoshimura, J. Kusano, T. Ishikawa, K. Murata, M. Fujita, A. Honda, M. Kinoshita, Y. Matsuzaki, T. Teramoto Japan 3.191 OVERWEIGHT DETERMINES THE INFLUENCE OF THE ADIPONECTIN G276T POLYMORPHISM ON LIPID LEVELS IN HEALTHY ADOLESCENTS Pía Riestra, A. García-Anguita, M.A. Lasunción, A. Mangas, C. Garces Spain 114 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NOVEL GENES RELATED TO ATHEROGENESIS – DO THEY ADD TO RISK PREDICTION OR TREATMENT? (contd.) 3.192 TIMP-4 SINGLE NUCLEOTIDE POLYMORPHISM AND CARDIAC FUNCTION IN HEART FAILURE PATIENTS Alberto Alves, Y. Rivlin, U. Rosenschein, F. Ribeiro, J.A. Duarte, M. Sagiv, J. Oliveira, E. Goldhammer Portugal 3.193 CORRELATION BETWEEN ANGIOTENSIN II TYPE 1 RECEPTOR POLYMORPHISMS AND CORONARY ARTERY CALCIFICATION IN CORONARY ARTERY DISEASE Amir Hooshang Mohammadpour, J. Behravan, S. Nazemi, M. Foroughi, N. Milani Moghaddam, H. Hashemizadeh Iran 3.194 VARIATION IN PROMOTER REGIONS OF GENES FOR CC CHEMOKINES CCL19 AND CCL21 IN CZECH MYOCARDIAL INFARCTION PATIENTS Jana Petrkova, A. Stahelova, M. Taborsky, F. Mrazek, M. Petrek Czech Republic 3.195 MONOCYTE CHEMOATTRACTANT PROTEIN-1 -2518A>G GENE POLYMORHISM AND THE RISK OF ISCHAEMIC STROKE IN CAUCASIAN SUBJECTS Anna Tavridou, E. Giannakopoulou, G. Ragia, S. Marousi, J. Ellul, V.G. Manolopoulos Greece 3.196 A5237G POLYMORPHISM OF CRP GENE IS ASSOCIATED WITH UNFAVOURABLE OUTCOMES IN PATIENTS WITH AFTER CORONARY SYNDROME Konstantin Aleksandrovich Blagodatskikh, A.A. Pushkov, A.G. Nikitin, M.A. Evdokimova, V.S. Osmolovskaya, D.A. Zateyshchikov, V.V. Nosikov Russia WORKSHOP: THROMBOGENIC RISK FACTORS FOR ATHEROTHROMBOSIS AND ACUTE CORONARY EVENTS (contd.) 3.197 PLASMA PHOSPHOLIPID TRANSFER PROTEIN (PLTP) IS A PROCOAGULANT FACTOR IN VIVO Catherine Desrumaux, V. Deckert, S. Lemaire-Ewing, C. Mossiat, A. Athias, D. Vandroux, L. Dumont, S. Monier, J.P. Pais de Barros, A. Klein, E. De Maistre, D. Blache, A. Beley, C. Marie, P. Garnier, L. Lagrost France 115 Genetics, Risk Factors and Epidemiology- from Population to Patients Poster No Poster Session Poster Area WORKSHOP: THROMBOGENIC RISK FACTORS FOR ATHEROTHROMBOSIS AND ACUTE CORONARY EVENTS (contd.) Poster No 3.198 MICRORNAS 340* AND 624* ARE UPREGULATED IN PLATELETS IN PATIENTS WITH CORONARY ARTERY DISEASE Brigitte Marlene Sondermeijer, A. Bakker, A. Halliani, S. Maiwald, S. Sivapalaratnam, T.A. Mulders, M.W.J. de Ronde, A.J. Tijsen, J.A. Marquart, P.D. Moerland, M.D. Trip, J.C.M. Meijers, E.E. Creemers, S.J. Pinto-Sietsma The Netherlands 3.199 GENETIC VARIATIONS, MRNA EXPRESSION AND CIRCULATING LEVELS OF MATRIX METALLOPROTEINASE-9 IN PATIENTS WITH CORONARY ARTERY DISEASE Trine Baur Opstad, A.Å. Pettersen, S. Åkra, T. Weiss, H. Arnesen, I. Seljeflot, Center for Clinical Heart Research Norway WORKSHOP: BIOMARKERS - FROM BENCH TO BEDSIDE (contd.) LOW HDL-CHOLESTEROL OF WOMEN AT RISK PREDICTED PRE-DIABETES Ruth Maria Korth Germany Genetics, Risk Factors and Epidemiology- from Population to Patients 3.200 116 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION 4.01 THE EFFECTS OF FETAL UNDERNUTRITION ON THE GENE EXPRESSION OF WHITE ADIPOSE TISSUE IN RAT Meiju Saukko, E. Malo, M. Santaniemi, M. Hietaniemi, O. Ukkola, Y.A. Kesäniemi Finland 4.02 THE EFFECT OF FETAL UNDERNUTRITION ON GLUCOSE METABOLISM IN RAT OFFSPRING Elina Malo, M. Saukko, M. Santaniemi, M. Hietaniemi, O. Ukkola, Y.A. Kesäniemi Finland 4.03 ADDING SKIMMED MILK TO A HIGH-FAT MEAL AFFECTS POSTPRANDIAL MARKERS FOR INFLAMMATION AND ENDOTHELIAL ACTIVATION IN OVERWEIGHT MEN Christiaan J. Masson, L.E. van Meijl, R.P. Mensink The Netherlands 4.04 PLANT STEROLS DO EXERT A MODEST SERUM TRIGLYCERIDE LOWERING EFFECT: A META-ANALYSIS OF INDIVIDUAL SUBJECT DATA Isabelle Demonty, L. Meijer, H.C.M. van der Knaap, R.T. Ras, P.L. Zock, J.M. Geleijnse, E.A. Trautwein The Netherlands 4.05 THE ROLE OF SOLUBLE FIBER INTAKE IN PATIENTS UNDER HIGHLY EFFECTIVE LPID-LOWERING THERAPY S.C. Ramos, F.A. Fonseca, S.H. Kasmas, F.T. Moreira, T. Helfenstein, N.C. Borges, R.A. Moreno, V.M. Rezende, F.C. Silva, Maria Cristina Izar Brazil 4.06 SERUM AMYLOID A DECREASES FOLLOWING FRUIT AND VEGETABLE INTERVENTION Nida Nadeem, J. Woodside, I. Young, J. McEneny UK 4.07 POSTPRANDIAL SERUM SITOSTANOL AND NON-CHOLESTEROL STEROLS AFTER AN ACUTE DOSE OF PLANT STANOL ESTER ON ITS CHRONIC CONSUMPTION Piia Simonen, H. Miettinen, H. Gylling, M. Hallikainen, M. Nissinen, T.A. Miettinen Finland 117 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.08 BENEFICIAL EFFECTS OF ALTERNATE DIETARY REGIMEN ON LIVER INFLAMMATION, ATHEROSCLEROSIS AND RENAL ACTIVATION Peter Y. Wielinga, G.K. Yakala, P. Heeringa, R. Kleemann, T. Kooistra The Netherlands 4.09 IS THE OMEGA-3 FATTY ACIDS SUPPLEMENTATION JUSTIFIED TO MODIFY MAJOR CARDIOVASCULAR OUTCOMES? A META-ANALYSIS E.C. Rizos, E.E. Ntzani, E. Bika, M. Kostapanos, Moses C. Elisaf Greece 4.10 VITAMIN B6, B12 AND FOLIC ACID SUPPLEMENTATION AND LONG-TERM PROGNOSIS AFTER ELECTIVE PERCUTANEOUS CORONARY INTERVENTION Olga Shakhmatova, A. Komarov, E. Panchenko Russia 4.11 ALCOHOL AND STIMULANTS DIETARY PATTERN IN RELATION TO HAPTOGLOBIN LEVELS, AMONG APPARENTLY HEALTHY INDIVIDUALS Vassiliki Bountziouka, A. Evangelopoulos, A. Giotopoulou, M. Bonou, N. Vallianou, P. Avgerinos, E. Vogiatzakis, J. Barbetseas, D. Panagiotakos Greece 4.12 INFLUENCE OF DIETARY PATTERNS ON VASCULAR HEALTH AND ITS RISK FACTORS Julie Ann Lanigan, S. Low, M. Kokoreli, K. Northstone, J. Deanfield, A. Lucas, A. Singhal UK 4.13 DEALCOHOLISED RED AND WHITE WINES ATTENUATE ATHEROSCLEROSIS IN APOE-DEFICIENT MICE BY UP-REGULATING HEME OXYGENASE-1 Maria Teresa Mitjavila, B. Bonacasa, M.C. Zaragozá, R.C. Siow, G.E. Mann, N. Martinez Spain 4.14 REDUCED ATHEROSCLEROTIC LESION DEVELOPMENT IN APOLIPOPROTEIN EDEFICIENT MICE FED A WESTERN-TYPE DIET ENRICHED WITH OIL FROM CALANUS FINMARCHICUS Karl-Erik Eilertsen, H. Mæhre, I.J. Jensen, B. Østerud, E.O. Elvevoll Norway 4.15 EFFECTS OF LEAN RED MEAT OR LEAN WHITE MEAT INTAKE ON THE LIPID PROFILE IN WOMEN: A RANDOMIZED CROSSOVER STUDY Rocio Mateo-Gallego, S. Perez-Calahorra, A.M. Bea, E. Burillo, J. Horno, E. Ros, F. Civeira Spain 118 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) 4.16 EFFECT OF OLEIC ACID IN COMBINATION WITH VARIED LEVELS OF FISH OIL ON THE LIPID PROFILE OF HEALTHY MEN Omar Obeid, D. El-Bistami, M. Mattar, S. Halis Lebanon 4.17 ADHERENCE TO THE MEDITERRANEAN DIET IS ASSOCIATED WITH REDUCED URIC ACID METABOLISM AMONG SUBJECTS WITH METABOLIC SYNDROME Christina Katsagoni, A. Evangelopoulos, A. Giotopoulou, M. Bonou, N. Vallianou, V. Bountziouka, P. Avgerinos, E. Vogiatzakis, J. Barbetseas, D.B. Panagiotakos Greece 4.18 EFFECT OF MODERATE INTAKE OF DIFFERENT ALCOHOLIC DRINKS OVER THE PLASMATIC CONCENTRATION OF PRO-INFLAMMATORY MARKERS INDUCED BY A FAT-ENRICHED DIET Ana Torres, V. Cachofeiro, E. Bello, J. Millán, C. Recarte, V. Lahera, L.A. Alvarez-Sala Spain 4.19 DIETARY CARBOHYDRATE, FATS, AND CORONARY ATHEROSCLEROSIS IN ASYMPTOMATIC POSTMENOPAUSAL WOMEN Min-Kyung Kim, H.E. Park, S.Y. Choi Republic of Korea 4.20 POTENTIAL BENEFITS OF CHILLI PEPPER IN A MEAL AND A CAPSULE Madeleine Ball, K. Ahuja, N. Green, M. Adams, I. Robertson Australia 4.21 LYCOPENE SUPPRESSES CYCLIC STRAIN-INDUCED ENDOTHELIN-1 EXPRESSION VIA THE INDUCTION OF ACTIVATING TRANSCRIPTION FACTOR 3 IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS Tzu-Hurng Cheng, H.H. Chao, J.J. Chen, J.C. Liu Taiwan R.O.C. 4.22 OLEUROPEIN REDUCES ENDOTHELIAL PROGENITOR CELLS SENESCENCE AND PROTECTS AGAINST OXIDATIVE STRESS INDUCED BY ANGIOTENSIN II Andrzej Parzonko, M. Naruszewicz Poland 4.23 A COMPARATIVE STUDY OF THE EFFECTS OF OLEUROPEIN AND OLEACEIN ON HUMAN NEUTROPHIL OXIDATIVE BURSTS AND MONOCYTES NITRIC OXIDE PRODUCTION Monika Czerwińska, A.K. Kiss, M. Naruszewicz Poland 4.24 DIETARY INTAKE OF PLANT STEROL ESTER ENRICHED MARGARINE INCREASES THE SERUM CONCENTRATION OF 7Β-HYDROXYSITOSTEROL IN HUMANS Constanze Husche, O. Weingärtner, U. Laufs, D. Lutjohann Germany 119 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.25 TOCOTRIENOL-TOCOPHEROL MIXED FRACTION SUPPLEMENTATION PREVENTS INFLAMMATION IN ESTABLISHED ATHEROSCLEROSIS N. Aishah, Effat Omar, A. Thuhairah, H. Nawawi Malaysia 4.26 POTASSIUM CHANNELS ARE INVOLVED IN THE VASODILATATION OF HUMAN UMBILICAL VEIN BY RESVERATROL Dragana Protic, S. Spremovic-Radjenovic, N. Radunovic, V. Kanjuh, H. Heinle, L. Gojkovic-Bukarica Serbia 4.27 REDUCED SERUM CHOLESTEROL CONCENTRATION IN CRTITICALLY ILL PATIENTS PREDICTS REQUIREMENT FOR PARENTERAL NUTRITION William Gordon Simpson, W.J. Mutch, R. Peake, B.L. Croal, K.A. Deans, M. Rehan, D. Noble UK 4.28 ANTIATHEROGENICITY OF HYDROPHILIC EXTRACTS FROM H. INCRASSATA SEAWEED IN VITRO AND IN VIVO Ariadna Costa-Mugica, D. Mondejar, A.E. Batista, A. Samokhin, D. Bromme, Y. Soto, V. Britto, A.M. Vázquez, C. Zaldivar, A. Vidal Cuba 4.29 ISOENERGETIC REPLACEMENT OF DIETARY SATURATED WITH MONOUNSATURATED FAT VIA MACADAMIA NUTS CAN AFFECT CORONARY RISK IN OVERWEIGHT SUBJECTS Shawn Somerset, L. Graham, K. Markwell, D. Colquhoun Australia 4.30 PREVALENCE OF THE COMPONENTS OF THE METABOLIC SYNDROME AND LIFESTYLE IN GERMAN YOUTH PARTICIPATING IN THE PEP FAMILY HEART STUDY Gerda Maria Haas, E. Liepold, P. Schwandt Germany 4.31 “BENEFICIAL EFFECT OF BANANA RESISTANT STARCH TO REDUCE GLYCEMIA AND LIPIDS IN TWO ANIMAL MODELS WITH DISMETABOLIC DISORDERS” Jorge L Ble-Castillo, M.A. Aparicio-Trápala, V. Olvera-Hernandez, A. Rodriguez-Hernandez, I.E. Juarez-Rojop, H. Aguilar-Mariscal, M.P. Vázquez-Sanchez, J.C. Diaz-Zagoya Mexico 4.32 THE SHORT-TERM EFFECT OF MEDITERRANEAN-TYPE DIET ON SERUM INFLAMMATORY MARKERS IN SUBJECTS WITH ABDOMINAL OBESITY Loukianos S Rallidis, A. Kolomvotsou, J. Lekakis, P. Farajian, G. Vamvakou, G. Liakos, S. Efstathiou, M. Anastasiou-Nana, A. Zampelas Greece 120 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) 4.33 BOTH PUFA-ENRICHED AND PUFA-DEPRIVED DIETS COUNTERACT AGE-RELATED HYPERCHOLESTEROLEMIA IN RATS Sara Straniero, G. Cavallini, A. Donati, M. Rudling, E. Bergamini Sweden 4.34 EFFECTS OF CONSUMPTION OF HYPERCHOLESTEROLEMIC DIETS CONTAINING GLUCOMANNAN AND SPIRULIN-ENRICHED SQUID-SURIMI ON PLASMA LIPID CONCENTRATIONS IN ZUCKER FA-FA RATS Miguel Vázquez-Velasco, L. González-Torres, R. Olivero, S. Bastida, F.J. Sánchez-Muniz, M.I. Sánchez-Reus, M.J. González-Muñoz, J. Benedí Spain 4.35 INSULIN RESISTANCE/SENSIBILITY BIOMARKERS CHANGES IN ZUCKER FA/FA RATS FED DIABETOGENIC DIET ENRICHED IN SQUID SURIMI CONTAINING GLUCOMANNAN AND A MICROALGA Miguel Vázquez-Velasco, L. González-Torres, A. Schultz, S. Bastida, F.J. Sánchez-Muniz, M.I. Sánchez-Reus, M.J. González-Muñoz, J. Benedí Spain 4.36 THE EFFECT OF WINE POLYPHENOL RESVERATROL IN THE RAT RENAL ARTERY Ljiljana Gojkovic-Bukarica, J. Markovic-Lipkovski, S. Cirovic, R. Novakovic, V. Kanjuh, H. Heinle Serbia 4.37 INHIBITORY EFFECT OF SALVIA MILTIORRHIZA ON OXIDATIVE STRESS AND APOPTOSIS IN ANIMAL MODEL OF ATHEROSCLEROSIS Weng-Cheng Chang, Y.M. Yu Taiwan R.O.C. 4.38 HIGH FULL FAT DAIRY PRODUCTS INTAKE IS ASSOCIATED WITH INCREASED BLOOD GLUCOSE LEVELS, AMONG HYPERTENSIVE PEOPLE Natalia Vallianou, V. Bountziouka, A. Evangelopoulos, M. Bonou, C. Katsagoni, J. Barbetseas, P. Avgerinos, E. Vogiatzakis, D. Panagiotakos Greece 4.39 CONSUMPTION OF STARCHY FOODS AND LEGUMES IS ASSOCIATED WITH INCREASED SERUM ALBUMIN LEVELS, AMONG HEALTHY ADULTS Amalia Giotopoulou, V. Bountziouka, A. Evangelopoulos, N. Vallianou, M. Bonou, J. Barbetseas, E. Vogiatzakis, P. Avgerinos, D. Panagiotakos Greece 4.40 A SIMPLE METHOD OF COMPARING DIETARY APPROACHES THAT REDUCE SATURATES, IMPROVE FAT QUALITY AND INDICATES LIKELY EFFECT ON BLOOD CHOLESTEROL Janice Irene Harland UK 121 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.41 COMPLIANCE TO TREATMENTS AND LIFESTYLE MEASURES CORONARY HEART DISEASE PATIENTS IN THE BANJA LUKA REPUBLIC OF SRPSKA/BOSNIA AND HERZEGOVINA 2004-2005 Dusko Vulic, S. Loncar, L. Sormaz, B. Vulic, J. Marinkovic, M. Ostojic Bosnia-Herzegovina 4.42 ETHANOLIC EXTRACT OF SEEDS OF LINUM USSITATTIMUM (FLAX LIGNAN CONCENTRATE) PREVENTS DOXORUBICIN-INDUCED CARDIOTOXICITY IN RATS Anand Zanwar, M.V. Hegde, S.L. Bodhankar India 4.43 GENE-DIET INTERACTION EFFECTS ON OXIDATIVE STRESS LEVELS IN INDIVIDUALS WITH STATIN-CONTROLLED DYSLIPIDAEMIA P.B. Botelho, C.O. Fioratti, M.M. Rogero, L.P. Barroso, M.C. Bertolami, Inar Alves Castro Brazil 4.44 COMPARATIVE STUDY OF THE ATHEROSCLEROTIC PARAMETERS IN MONGOLIAN AND JAPANESE PATIENTS WITH HYPERTENSION AND DIABETES MELLITUS Uurtuya Shuumarjav, K. Kotani Mongolia 4.45 INVESTIGATING THE IMPACT OF DIETARY AND PHYSICAL ACTIVITY TARGET ACHIEVEMENT ON WEIGHT AND WAIST CIRCUMFERENCE IN CORONARY HEART DISEASE PATIENTS Rooshi Nathwani UK 4.46 PENTA-O-GALLOYL-Β-D-GLUCOSE INHIBITS NEUTRAL ENDOPEPTIDASE (NEP) ACTIVITY AND ROS PRODUCTION IN NEUTROPHILS ISOLATATES FROM HEALTHY SUBJECTS AND FROM PATIENTS WITH AMI Anna Kiss, A. Kapłon -Cieślicka, K. Filipiak, G. Opolski, M. Naruszewicz Poland 4.47 EFFECT OF THERAPEUTIC LIFESTYLE CHANGE ON HIGH DENSITY LIPOPROTEIN CHOLESTEROL IN PATIENTS WITH METABOLIC SYNDROME Sang Hyun Kim, H.L. Lee, J.B. Seo, W.Y. Chung, J.H. Zo, M.A. Kim Republic of Korea 4.48 INTERMITTENT FASTING: PHYSIOLOGICAL DATA REGARDING A NEW APPROACH FOR THE NUTRITIONAL PREVENTION OF ATHEROSCLEROSIS Edielle Santanna Melo, F. Reis de Azevedo, L.H. Monteiro, B. Caramelli Brazil 4.49 THE INFLUENCE OF DIET ON LEVEL OF ENDOGENOUS MELATONIN, VASCULAR INFLAMMATION AND LIPID PROFILE IN HYPERTENSIVE PATIENTS Corina Grigore, O. Grigore, L. Dawkins, D. Isacoff, I. Bruckner Romania 122 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) Poster No 4.50 DETERMINATION OF HOMOCYSTEINE VALUES ON OBESE PATIENTS ASSOCIATED WITH NUTRITION S. Patiakas, Charalampos Charalampous Greece 4.51 OMEGA-3 FATTY ACID ENRICHED EGGS ARE HEART FRIENDLY M.V. Hegde, Anand Arvind Zanwar, S.A. Khan, U.V. Wagh India 4.52 THE ROLE OF CERTAIN NATURAL POLYPHENOLS IN EXPERIMENTAL ARTERIAL HYPERTENSION Manuela Ciocoiu, A. Miron, C. Badescu, D. Tutunaru, M. Badescu Romania 4.53 THE BENEFICIAL EFFECTS OF NATURAL POLYPHENOLS ON THE DISLIPIDEMY AND EYE COMPLICATIONS IN THE EXPERIMENTAL DIABETES MELLITUS Magda Badescu, C. Badescu, D. Tutunaru, O. Badulescu, M. Ciocoiu Romania 4.54 MODES OF ACTION OF SOY CONSTITUENTS IN LDL MANAGEMENT Jan H. van Ee The Netherlands 4.55 CORRELATION OF ANTHROPOMETRIC INDICES LIKE ABDOMINAL CIRCUMFERENCE AND BODY MASS INDEX IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE(NAFLD) Ileana Pantea, O. Andreescu, L. Nedelcu, C. Scarneciu, M. Vâlcu, I. Brezean Romania 4.56 EXTENSIVE MANAGEMENT APPROACH IN THE TREATMENT OF OBESITY - FIRST RESULTS Ursula Kassner, A. Binder, A. Ahnis, M. Haupt, B. Klapp, E. Steinhagen-Thiessen, E. Giannakidou-Jordan Germany 4.57 CAROTID PLAQUE MEASUREMENT IS SUPERIOR TO IMT J. David Spence Canada 4.58 C-REACTIVE PROTEIN IS NOT ASSOCIATED WITH CAROTID TOTAL PLAQUE AREA OR STENOSIS J. David Spence Canada 123 Diagnosis, Prevention and Treatment of Cardiovascular Disease WORKSHOP: CEREBROVASCULAR DISEASE - PREVENTION AND TREATMENT Poster Session Poster Area WORKSHOP: CEREBROVASCULAR DISEASE - PREVENTION AND TREATMENT (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.59 CLOPIDOGREL VERSUS ASPIRIN TREATMENT ON ADMISSION IMPROVES 5-YEAR SURVIVAL AFTER A FIRST-EVER ACUTE ISCHEMIC STROKE Michael S Kostapanos, H.J. Milionis, G. Gerotziafas, A. Vemmou, P. Zis, K. Spengos, M.S. Elisaf, K.N. Vemmos Greece 4.60 MAJOR ADVERSE CARDIAC EVENTS AND MORTALITY IN PERIPARTUM LUPUS PATIENTS: A POPULATION-BASED STUDY Pao-Hsien Chu, C.H. Tang Taiwan R.O.C. 4.61 FORMONONETIN, A CLA1 UPREGULATOR, REDUCES ATHEROSCLEROTIC LESION FORMATION IN APOE-/- MICE Y. Xu, Q. Liu, P. Zhao, N. Li, F. Lai, Y. Xu, X. He, W. Jiang, B. Hong, Shuyi Si China 4.62 TOTAL SERUM B12 AND HOMOCYSTEINE LEVELS ARE ASSOCIATED WITH INCREASED RISK OF COGNITIVE DYSFUNCTION: A 4 YEARS PROSPECTIVE STUDY Christina Voulgari, S. Paximadas, P. Dilaveris, C. Stefanadis, N. Katsilambros, N. Tentolouris Greece 4.63 YKL-40 IN CAROTID ATHEROSCLEROSIS Annika Elisabet Michelsen, C.N. Rathcke, M. Skjelland, S. Holm, T. Ranheim, K. Krohg-Sørensen, M. Klingvall, F. Brosstad, E. Øie, H. Vestergaard, P. Aukrust, B. Halvorsen Norway 4.64 STRUCTURE AND CYTOKINE PATTERN OF CAROTID PLAQUES IN ELDERLY PATIENTS Helena Grufman, A. Edsfeldt, A. Persson, M. Nitulescu, M. Nilsson, J. Nilsson, I. Goncalves Sweden 4.65 COMPARISON OF THE NEW UNIFIED CRITERIA FOR METABOLIC SYNDROME WITH CONVENTIONAL IDF CRITERIA: RISK FOR DEVELOPING CARDIOVASCULAR DISEASE Jiro Suwa Japan 4.66 CEREBRAL MICROBLEEDS IS ASSOCIATED WITH ARTERIAL CALCIFICATION Kwang-Yeol Park, P.W. Chung Republic of Korea 124 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: CEREBROVASCULAR DISEASE - PREVENTION AND TREATMENT (contd.) Poster No 4.67 RELATIONSHIP BETWEEN PLASMA ADMA LEVELS AND CAROTID NARROWING DEGREE IN CAROTID ENDARTERECTOMY (CEA) PATIENTS A. Zinellu, M.A. Casu, F. Piredda, P. Porcu, L. Deiana, Ciriaco Carru Italy 4.68 COMPREHENSIVE METABOLIC PROFILING IN RISK STRATIFICATION OF HUMAN CAROTID ATHEROSCLEROSIS Joseph Shalhoub, P.A. Vorkas, C. Monaco, E.J. Want, M.R. Lewis, A.H. Davies, E. Holmes, J.K. Nicholson UK 4.69 EFFECT OF PHYSICAL ACTIVITY ON IMT OF CAROTID ARTERY IN SMOKERS Hiroyuki Katano, M. Ohno, K. Yamada Japan 4.70 CAROTID RESTENOSIS AFTER ENDARTERECTOMY: THE ROLE OF APOLIPOPROTEINS Simone Vidale, S. Bellocchi, P. Casiraghi, D. Trevisan, M. Arnaboldi, R. Caronno, A. Taborelli Italy 4.71 ENDOTHELIALIZATION AND IN-STENT RESTENOSIS OF GLYCOPROTEIN IIIA MONOCLONAL ANTIBODY ELUTING STENT Tieying Yin, G. Wang, D. Du, Z. Li, L. Luo, D. Zhang, Y. Wang, C. Ruan China 4.72 EVALUATION OF CHOLESTEROL LOWERING TREATMENT OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA. Vasiliki Metaxa, I. Skoumas, C. Pitsavos, E. Oikonomou, E. Tsetsekou, C. Chrysochoou, K. Masoura, C. Stefanadis Greece 4.73 PLANT STEROL AND STANOL ESTERS INDUCE DIFFERENTIAL EFFECTS ON OXIDATIVE STRESS, INFLAMMATION, LEUCOCYTES, VASCULAR FUNCTION AND TISSUE CONCENTRATIONS IN MICE Oliver Weingärtner, C. Ulrich, D. Lütjohann, K. Ismail, S.H. Schirmer, T. Vanmierlo, M. Böhm, U. Laufs Germany 125 Diagnosis, Prevention and Treatment of Cardiovascular Disease WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.74 HIGH SODIUM INTAKE INCREASES INFLAMMATORY ACTIVITY, CARDIAC PRESSURE OVERLOAD AND TOTAL MORTALITY AFTER MYOCARDIAL INFARCTION Guilherme Fernandes de Carvalho, A.P.R. Costa, U.C.P. Silva, J.M. Andrade, E.C. de Faria, D.S.P. Abdalla, O.L.R. de Almeida, S.N. Santos, J.C. Quinaglia e Silva, O.R. Coelho, A.C. Sposito, Brasília Heart Study Group Brazil 4.75 THE INFLUENCE OF DOCOSAHEXAENOIC ACID SUPPLEMENTATION ON VASCULAR FUNCTION: A DOUBLE-BLIND PLACEBO-CONTROLLED RANDOMISED TRIAL Atul Singhal, J.A. Lanigan, S. Low, A. Lucas, J. Deanfield UK 4.76 NON-FAT DAIRY PRODUCTS ARE ASSOCIATED WITH LOWER TRIGLYCERIDE CONCENTRATIONS IN A SPANISH HYPERTRIGLYCERIDAEMIC COHORT Jordi Merino, R. Mateo-Gallego, N. Plana, A.M. Bea, J. Ascaso, C. Lahoz, J.L. Aranda, on behalf of the Hypertriglyceridemia Registry of the Spanish Arteriosclerosis Society Spain 4.77 EFFECTS OF PLANT STEROL- OR STANOL-ENRICHED MARGARINE ON SERUM OXYPHYTOSTEROL CONCENTRATIONS IN HEALTHY SUBJECTS Sabine Baumgartner, R.P. Mensink, C. Husche, D. Lütjohann, J. Plat The Netherlands 4.78 SIMULTANEOUS INTAKE OF OAT BRAN AND ATORVASTATIN REDUCES THEIR EFFICACY TO LOWER TOTAL CHOLESTEROL AND ATHEROSCLEROSIS IN LDLRECEPTOR-DEFICIENT MICE Simone Eussen, C. Rompelberg, K. Andersson, O. Klungel, P. Hellstrand, R. Öste, J. Garssen The Netherlands 4.79 ADHERENCE TO THE MEDITERRANEAN DIET IS ASSOCIATED WITH DECREASED HAPTOGLOBIN LEVELS, AMONG APPARENTLY HEALTHY INDIVIDUALS Vassiliki Bountziouka, A. Evangelopoulos, C. Katsagoni, M. Bonou, N. Vallianou, P. Avgerinos, E. Vogiatzakis, D. Panagiotakos Greece 126 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: HEALTHY DIETS AND FUNCTIONAL FOOD – A ROAD TO PREVENTION (contd.) Poster No 4.80 LIPID RESPONSE TO PHYTOSTEROLS IN A HYPERCHOLESTEROLEMIC POPULATION IS NOT AFFECTED BY APOLIPOPROTEIN E POLYMORPHISM OR DIAMETER OF LOW-DENSITY LIPOPROTEIN Victor M Victor, C. Bañuls, L. Bellod, A. Jover, M. Rocha, A. Hernandez-Mijares Spain 4.81 CAROTID ARTERY PLAQUE: THE ROLE OF IL-8 AND PTX-3 IN ASYMPTOMATIC AND SYMPTOMATIC PATIENTS. Stefania Ferraro, L. Schembri, M. Tozzi, G. Piffaretti, F. Marino, P. Castelli Italy 4.82 THE ASSOCIATION OF CXCL16 A181V GENE POLYMORPHISM WITH CAROTID ATHEROSCLEROSIS IN PATIENTS SUBJECTED TO ENDATERECTOMY Maja Zivkovic, M. Popovic, L. Stojkovic, D. Radak, I. Koncar, L. Davidovic, A. Kolakovic, A. Stankovic, D. Alavantic Serbia 4.83 RELATIONSHIP BETWEEN ABDOMINAL OBESITY AND OTHER CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH SYMPTOMATIC CAROTID ATHEROSCLEROSIS Milos Maksimovic, H. Vlajinac, D. Radak, J. Marinkovic, J. Maksimovic, J. Jorga Serbia 4.84 DAILY CONSUMPTION OF VITAMIN D-FORTIFIED YOGURT DRINK BOTH IMPROVED GLYCEMIC CONTROL AND DECREASED SERUM CARDIAC MYEOLOPEROXIDASE IN TYPE 2 DIABETICS Tirang R Neyestani, B. Nikooyeh, H. Alavi-Majd, A. Gharavi, A. Kalayi, N. Shariatzadeh, S. Heravifard, N. Tayebinejad, S. Salekzamani, M. Zahedirad Iran 4.85 EVALUATION OF THE SELF-DESIGNED ULTRASONIC ATOMIZATION SPRAYING EQUIPMENT FOR INTRAVASCULAR STENTS Y. Chen, G. Wang, Y. Hou, Chiming Wei, T. Yin, L. Luo, H. Chen, C. Tang China 4.86 EFFECT OF QUERCETIN ON VIABLE MYOCARDIUM IN PATIENTS WITH ST ELEVATION ACUTE MYOCARDIAL INFARCTION A. Alavy Lutfullaevich, Sirojiddin Kenjaev Rashidovich, M. Kenjaev Latipovich Uzbekistan 127 Diagnosis, Prevention and Treatment of Cardiovascular Disease WORKSHOP: CEREBROVASCULAR DISEASE - PREVENTION AND TREATMENT (contd.) Poster Session Poster Area WORKSHOP: CEREBROVASCULAR DISEASE - PREVENTION AND TREATMENT (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.87 THE EFFECT OF NICOTINIC ACID/LAROPIPRANT ON LIPIDS, FASTING PLASMA GLUCOSE, GLYCOSYLATED HEMOGLOBIN AND URIC ACID IN PATIENTS WITH MIXED DYSLIPIDEMIA A. Kei, E. Liberopoulos, E. Moutzouri, C. Rizos, Moses Elisaf Greece 4.88 PREVALENCE OF ABDOMINAL AORTIC ANEURYSM BY MAGNETIC RESONANCE IMAGES (MRI) IN MEN OVER 50 YEARS WITH LOW BACK PAIN Moslem Shakeri Bavil Iran 4.89 TREATMENT OF DYSLIPIDEMIA IN PATIENTS WITH METABOLIC SYNDROME USING SIMVASTATIN AND URSODEOXYCHOLIC ACID Oxana M Drapkina, V.T. Ivashkin Russia 4.90 THE FEATURES OF CEREBRAL HEMODYNAMICS IN PATIENTS WITH CORONARY HEART DISEASE END DIABETES MELLITUS TYPE 2 Olga Sheludchenko Ukraine 4.91 NORPURPURINE, ALKALOID ISOLATED FROM THE LEAVES OF ANNONA INCONFORMIS, HAS ANTI-AGGREGATING EFFECTS ON HUMAN PLATELETS G. Sanchez, G. Acha, O. Estrada, A. Cardozo, M.C. Ruiz, A.Z. Fernandez, Claudia Pilar Alvarado-Castillo Venezuela 4.92 STRONG ASSOCIATION OF PERIODONTAL DISEASE WITH STROKE Leopoldo Penteado Nucci da Silva1,2, I.G. Pedron, J.L. Simone, C. Gun Brazil 4.93 GENDER DIFFERENCES IN THE DEVELOPMENT OF SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH EARLY SIGNS OF CEREBROVASCULAR INSUFFICIENCY Veronika Alexandrovna Myasoedova, I.A. Sobenin, D.M. Merculova, T.V. Kirichenko, U.A. Merculov, A.N. Orekhov Russia 4.94 PREVALENCE OF METABOLIC SYNDROME IN PATIENTS WITH OSTEOPOROSIS Dimitris Agapakis, E. Alexiou, I. Floudaras, S. Maraslis, C. Chatziathanasiadou, M. Damianidou, S. Sereti, E. Satsoglou Greece 128 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: CEREBROVASCULAR DISEASE - PREVENTION AND TREATMENT (contd.) 4.95 EFFECT OF CASPASE INHIBITOR AC-DEVD-CHO ON APOPTOSIS OF VASCULAR SMOOTH MUSCLE CELLS INDUCED BY ARTESUNATE J. Zhang, H. Chen, G. Wang, T. Yin, Y. Teng, Chaojun Tang China 4.96 INHIBITORY EFFECTS OF SAPPAN LIGNUM EXTRACT ON VASCULAR RESTENOSIS IN THE RAT CAROTID ARTERY BALLOON INJURY MODEL G. Wang, G. Long, B. Ling, C. Wei, H. Chen, L. Wu, T. Yin, Chaojun Tang China 4.97 THE IMPACT OF LOW DENSITY LIPOPROTEIN RECEPTOR(LDLR) GENE MUTATION ON INCIDENCE OF PREMATURE CARDIOVASCULAR DISEASE, IN FAMILIAL HYPERCHOLESTEROLEMIC PATIENTS Vasiliki Metaxa, C. Pitsavos, I. Skoumas, A. Miliou, E. Oikonomou, K. Masoura, C. Stefanadis Greece 4.98 ASSOCIATION OF MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR POLYMORPHISM WITH STROKE IN CAUCASIAN POPULATION OF SIBERIA M. Voevoda, Vladimir Maksimov, S. Shishkin, E. Shakhtshneider, A. Romaschenko Russia 4.99 EMBOLIC OCCLUSION OF THE MIDDLE AND INTERNAL CAROTIDE ARTERY. EMERGENT TREATMENT WITH RT-PA THROMBOLYTIC AGENT Apostolos Limuris, N. Fistas Greece 4.100 DETERMINANTS OF THE CEREBROVASCULARE REACTIVITY BY ELDERLY PATIENTS WITH CORONARY HEART DISEASES Gulnora Rozikhodjaeva Uzbekistan 4.101 INTIMA-MEDIA THICKNESS OF COMMON AND INTERNAL CAROTID ARTERIES IN PATIENTS WITH HEPATOSPLENIC SCHISTOSOMIASIS MANSONI Carlos Teixeira Brandt, A.V. Guimarães, Schistosomiasis Mansoni Brazil 4.102 AN ASSESSMENT OF POTENTIAL ANORECTIC, LIPOLYTIC AND WEIGHT REDUCING PROPERTIES OF KOLANUT (C.NITIDA) IN ADULT WISTER RATS Sunny Banjoko, O. Ogunleye, O. Babalola, A. Ayoka Nigeria 4.103 STATE OF SYSTEM METABOLISM IN PATIENTS AFTER MYOCARDIAL INFARCTION IN CONCOMITANT ARTERIAL HYPERTENSION Valentyn A. Shumakov, I. Malynovska, T. Talaeva, L. Tereshkevysh,, I. Gotenko, O. Yanus Ukraine 129 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: CEREBROVASCULAR DISEASE - PREVENTION AND TREATMENT (contd.) Poster No 4.104 THE ROLE OF OMACOR TREATMENT IN MORPHOLOGICAL CHANGES OF VENOUS GRAFTS IN PATIENTS AFTER SURGICAL MYOCARDIAL REVASCULARISATION A.V. Panov, L.B. Mitrofanova, M.Z. Alugishvili, Elena A. Usova Russia 4.105 INCREASING BIOLOGICAL EFFECTIVENESS OF ANTISENSE OLIGONUCLEOTIDES TARGETING APOB BY INTRODUCTION OF MISMATCHES Mikhail Voevoda, A. Dudarev, M. Ivanova, Y. Ragino Russia 4.106 ENDOTHELIAL FUNCTION, ANTICOAGULATIVE SYSTEM AND FIBRINOLYSIS FEATURES IN PATIENTS WITH ISCHEMIC STROKE, CAUSED BY ATHEROSCLEROSIS AND ARTERIAL HYPERTENSION Alla Anatolevna Shabalina, M.V. Kostyreva, M.Y. Maksimova, V.G. Ionova Russia 4.107 ARTERIAL HYPERTENSION AND ATHEROSCLEROSIS IN THE AGED WOMEN Nina K. Gorshunova, E.V. Tereshina, D.N. Ukraintzeva Russia 4.108 12- AND 15-LIPOXYGENASES IN HUMAN CAROTID ATHEROSCLEROTIC LESIONS: ASSOCIATIONS WITH CEREBROVASCULAR SYMPTOMS Karl Gertow, E. Nobili, L. Folkersen, J.W. Newman, T.L. Pedersen, J. Ekstrand, J. Swedenborg, H. Kühn, C.E. Wheelock, G.K. Hansson, U. Hedin, J.Z. Haeggström, A. Gabrielsen Sweden 4.109 EPIGENETIC CHANGES IN HUMAN ADVANCED CAROTID ARTERY LESIONS Jaroslav Pelisek, M. Culmes, R. Napieralski, H.H. Eckstein Germany WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT Diagnosis, Prevention and Treatment of Cardiovascular Disease 4.110 ETOPOSIDE ASSOCIATED WITH CHOLESTEROL-RICH NANOEMULSIONS REDUCE ATHEROSCLEROTIC LESIONS IN RABBITS Raul C. Maranhão, E.R. Tavares, F.R. Freitas, J. Diament Brazil 130 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) 4.111 BARIATRIC SURGERY AND PREVENTION OF MYOCARDIAL INFARCTION IN OBESE INDIVIDUALS WITH TYPE 2 DIABETES IN THE SWEDISH OBESITY SUBJECTS STUDY Cristina Maglio, C. Pirazzi, M.A. Burza, M. Peltonen, L. Sjöström, L.M. Carlsson, S. Romeo Sweden 4.112 THE RELATIONSHIP BETWEEN STATIN THERAPY AND PROGRESSION OF RENAL DAMAGE AMONG 10305 HYPERTENSIVE PATIENTS RANDOMISED IN THE ASCOT-LIPID-LOWERING ARM (LLA) Ajay Gupta, C.L. Chang, D. Collier, B. Dahlof, N.R. Poulter, P.S. Sever, on behalf of the ASCOT Investigators UK 4.113 PEPTIDE-BASED IMMUNIZATION AGAINST PCSK9 REDUCES TOTAL CHOLESTEROL IN MICE Gergana Galabova, G. Winsauer, B. Wanko, F. Mattner, W. Schmidt, S. Brunner Austria 4.114 MIPOMERSEN, AN APOB SYNTHESIS INHIBITOR, EVALUATION OF POTENTIAL TO REDUCE NECESSITY FOR LIPID-APHERESIS IN PATIENTS WITH HETEROZYGOUS FH AND CAD Klaus G. Parhofer, A. Vogt Germany 4.115 A RANDOMIZED TRIAL OF ATORVASTATIN PLUS ETIDRONATE COMBINATION THERAPY FOR ATHEROSCLEROTIC AORTIC PLAQUES Tetsuya Kawahara, M. Nishikawa, T. Furusawa, T. Inazu, G. Suzuki Japan 4.116 5-AMINOLEVULINIC ACID-DERIVED PROTOPORPHYRIN IX MEDIATED FLUORESCENCE DIAGNOSIS AND PHOTODYNAMIC THERAPY OF MACROPHAGES WITHIN THE ATHEROSCLEROTIC PLAQUE Ye Tian, C. Peng, X. Sun, J. Cheng, L. Yang, J. Wu, Z. Zhang, W. Cao China 131 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.117 EFFECT OF MIPOMERSEN ON LP(A) IN PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA; RESULTS FROM TWO PHASE 3 STUDIES Elisabeth Steinhagen-Thiessen, J.L. Witztum, S. Tsimikas, J.M. Donovan, W. Cromwell Germany 4.118 OCCURRENCE OF CORONARY HEART DISEASE IN A COHORT OF HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIC PATIENTS IN NORWAY Gisle Langslet, T. Dadd, A. Jarman, K. Retterstøl, L. Ose Norway 4.119 NITRIC OXIDE-DONATING STATINS EXERT BENEFICIAL EFFECTS ON ACUTE VASCULAR INFLAMMATION IN NORMOCHOLESTEROLEMIC RABBITS R. Baetta, A. Granata, L. Arnaboldi, N. Ferri, S. Bellosta, A. Bonomo, D. Miglietta, P. Pfister, Alberto Corsini Italy 4.120 LONG TERM COURSE IN PATIENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA UNDERGOING LIPID-APHERESIS Anja Vogt, C. Keller, N. Weiss Germany 4.121 EFFECTS OF VARIOUS LIPID-LOWERING DRUGS ON DIABETIC NEPHROPATHY IN DB/DB MICE Hidenori Arai, Y. Tamura, T. Murayama, M. Minami, M. Yokode Japan 4.122 CARDIOVASCULAR EVENT RATE IN STABLE CORONARY PATIENTS WITH CHRONIC KIDNEY DISEASE (CKD) INCREASED BY BEING OBESE IS REDUCED BY ATORVASTATIN Prakash Deedwania, J. Shepherd, D. Wilson, the Treating to New Targets (TNT) Investigators USA 4.123 ANTIATHEROSCLEROTIC POTENTIAL OF PHENOLIC COMPOUNDS: AN EXPERIMENTAL STUDY IN RABBITS Bassim Irheim Mohammad, N.R. Hadi, M. Sahlawi Iraq 4.124 METABOLIC SYNDROME IS ASSOCIATED WITH ELEVATED GLOMERULAR FILTRATION RATE AND INCREASED RENAL RESISTANCE INDEX Gustavo Giunta, A. Fava, G. Trentadue, P. Mendez, A. Hnatiuk, L. Chiaramonte, A. Pereyra, P. D'Angelo, L. Cuniberti, H. Baglivo, R. Sanchez Argentina 132 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) 4.125 CURRENT STATIN TREATMENT OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLAEMIA (FH): RESULTS FROM THE ROYAL COLLEGE OF PHYSICIANS UK NATIONAL AUDIT Mary Seed, M. Roughton, D. Nair, K. Pederson, T. Wang, A.H.W. Neil, S.E. Humphries UK 4.126 LOW CHOLESTEROL IN MIDLIFE PREVENTS MORTALITY AND PREDICTS SUCCESSFUL OLD AGE Laura Hyttinen, T.E. Strandberg, A.Y. Strandberg, V.V. Salomaa, K.H. Pitkälä, R.S. Tilvis, T.A. Miettinen Finland 4.127 ASYMPTOMATIC SUBJECTS WITH A POSITIVE FAMILY HISTORY FOR PREMATURE CORONARY ARTERY DISEASE BENEFIT FROM PREVENTIVE TREATMENT: A POSTHOC ANALYSIS T. Mulders, S. Sivapalaratnam, E. Stroes, A. Guerci, S. Pinto-Sietsma The Netherlands 4.128 DYSLIPIDEMIA REVEALED IN NEONATES - SIGNIFICANT ASPECTS OF GENETIC PREDISPOSES OF ATHEROSCLEROSIS Nodar N. Kipshidze, K.A. Nadaraia, A.T. Jabauri, T.A. Gegenava Georgia 4.129 DOES SARPOGRELATE TREATMENT REDUCE NEO-INTIMAL HYPERPLASIA IN PATIENTS UNDERWENT PERCUTANEOUS CORONARY INTERVENTION WITH DRUG-ELUTING STENTS? Jae-Hun Jung, P.K. Min, T.S. Kang, J.H. Seong, J.Y. Kim, B.K. Kim Republic of Korea 4.130 ENHANCING BAROREFLEX ACTIVITY AS A NOVEL TARGET FOR TREATING ATHEROSCLEROSIS DEPENDS ON CHOLINERGIC ANTI-INFLAMMATORY PATHWAY Guo-Jun Cai China 4.131 A PACLITAXEL DERIVATIVE (PACLITAXEL OLEATE) ASSOCIATED WITH A CHOLESTEROL-RICH NANOEMULSION DECREASES THE TRANSPLANT HEART VASCULAR DISEASE IN RABBIT GRAFT MODEL Raul Maranhão, D.D. Lourenço-Filho, C.A. Méndez-Contreras, E.R. Tavares, F.R. Freitas, N.A. Stolf Brazil 133 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.132 EFFECTIVITY OF COLESEVELAM IN STATIN INTOLERANT PATIENTS ± EZETIMIBE Stefanie Maierhofer, A. deCampo, T. Stojakovic, H. Jahnel, H. Toplak Austria 4.133 THE PROGNOSTIC SIGNIFICANCE OF THE FREQUENCY AND THE MORPHOLOGY OF PREMATURE VENTRICULAR CONTRACTIONS DURING AMBULATORY HOLTER MONITORING Georges Ephrem, M. Levine, P. Friedmann, P. Schweitzer USA 4.134 ACCURACY AND PRECISION OF POINT-OF-CARE TESTING FOR SERUM CHOLESTEROL, TRIGLYCERIDES AND HDL CHOLESTEROL J.V. Patel, G. Thorpe, L. Springer, Elizabeth A. Hughes UK 4.135 MORE AGGRESSIVE LDL-C AND NON-HDL-C TARGETS MUST BE ACHIEVED IN PATIENTS RECEIVING LIPID-LOWERING THERAPY TO NORMALIZE APOBCONTAINING LIPOPROTEINS John Betteridge, J.R. Guyton, M. Farnier, L.A. Leiter, J. Lin, A. Shah, A.O. Johnson-Levonas, P. Brudi UK 4.136 FAVOURABLE IMPACT ON LIPID LEVELS OF INCREASING STATIN DOSE IN HIGHRISK PATIENTS WITH VERY HIGH BASELINE LDL-C: RESULTS FROM VOYAGER P. Lundman, M.K. Palmer, B.W. Karlson, P.J. Barter, S.J. Nicholls Sweden 4.137 EFFECT OF ROSUVASTATIN AND ATORVASTATIN DOSE ON LDL-C < 70MG/DL GOAL ATTAINMENT IN PATIENTS WITH DIABETES MELLITUS: RESULTS FROM VOYAGER B. W. Karlson, P.J. Barter, M.K. Palmer, P. Lundman, S.J. Nicholls Sweden 4.138 INCREASED CARDIOVASCULAR EVENT RATE IN STABLE CORONARY PATIENTS WITH METABOLIC SYNDROME COMPLICATED BY CHRONIC KIDNEY DISEASE IS REDUCED BY ATORVASTATIN Prakash Deedwania, J. Shepherd, D. Wilson, the Treating to New Targets (TNT) Investigators USA 4.139 PREDICTION OF CARDIOVASCULAR EVENTS IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS Anne Grete Semb, T.K. Kvien, R. Fayyad, D. DeMicco, T.R. Pedersen, J.C. LaRosa, J. Betteridge, I. Holme Norway 134 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) 4.140 INFLUENCE OF OBESITY AND THE ONSET OF THE DISEASE ON EARLY ATHEROSCLEROSIS CHANGES IN CHILDREN WITH JUVENILE CHRONIC ARTHRITIS (JCA) Barbara Głowińska-Olszewska, E. Dobreńko, A. Hryniewicz, M. Wojciuk, B. Żelazowska-Rutkowska, W. Łuczyński, D. Piotrowska-Jastrzębska, A. Bossowski Poland 4.141 PREVALENCE OF LOW HDL AND HIGH TRIGLYCERIDES IN PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE IN EUROPE: THE EURIKA STUDY Julian Halcox, on behalf of the EURIKA Steering Committee UK 4.142 EFFECT OF INTENSIVE LIPID LOWERING ON CARDIOVASCULAR OUTCOME IN PATIENTS WITH AND WITHOUT INFLAMMATORY JOINT DISEASE Anne Grete Semb, T.K. Kvien, R. Fayyad, D. DeMicco, J.C. LaRosa, T.R. Pedersen, J. Betteridge, I. Holme Norway 4.143 EFFECT OF DOXYCYCLINE ON ATHEROSCLEROSIS PROGRESSION IN HYPERCHOLESTEROLEMIC RABBITS Najah Raiesh Hadi, B.I. Mohammad, H.A. Chassap Iraq 4.144 DIABETES: THE MAIN PREDICTOR OF EXTENSIVE CORONARY CALCIFICATION IN STABLE ANGINA? Rachel Nicoll, A. Magedanz, Y. Zhao, U. Wiklund, A. Schmermund, M. Henein Sweden 4.145 PHENOTYPIC DIFFERENCES OF PATIENTS WITH MOLECULARLY DEFINED APOB AND LDLR DEFECTIVE HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA Anja Vogt, C. Keller, C. Heigl, N. Weiss Germany 4.146 GENDER DIFFERENCES IN PREVALENCE AND CONTROL OF CARDIOVASCULAR DISEASE RISK FACTORS AMONG PATIENTS WITH TYPE 2 DIABETES: THE MIND.IT STUDY Laura Franzini, D. Ardigò, F. Cavalot, R. Miccoli, A. Rivellese, M. Trovati, I. Zavaroni, O. Vaccaro, MIND.IT Study Group Italy 4.147 COMPARISON OF DRUG-ELUTING STENT VERSUS BARE METAL STENT IN RENAL TRANSPLANT PATIENTS Jae-Hun Jung, P.K. Min, Y.G. Ko, D. Choi, Y. Jang, K.J. Lee, K.H. Park, M.K. Kim Republic of Korea 135 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.148 LONGITUDINAL ANALYSIS OF THE EFFECT OF HEART RATE SYNCHRONIZED LOCAL SOUND WAVE THERAPY FOR CIRCULATORY SYSTEM Ferenc Ihász, Z. Szabo, A. Széll, J. Rikk, Group of Sonoterapy Hungary 4.149 ASSOCIATION BETWEEN ARTERIAL STIFFNESS AND ESTIMATED GLOMERULAR FILTRATION RATE IN CHRONIC KIDNEY DISEASE PATIENTS Enkhtuvshin Enkhtamir, T. Ariunaa, E. Odkhuu, M. Munkhzol Mongolia 4.150 TREATMENT OF PATIENTS WITH HEART FAILURE WITH PRESERVED SYSTOLIC FUNCTION: INFLUENCE OF BETA-BLOCKER ON ENDOTHELIAL FUNCTION, ALBUMINURIA AND FIBRONECTINE Olena Soya, O. Kuryata, A. Miroshnichenko Ukraine 4.151 CORRELATION BETWEEN LDL-LOWERING BY STATINS AND HEMORHEOLOGICAL PROFILES: A SUBSTUDY OF THE PATROL TRIAL Keijiro Saku, B. Zhang, Y. Uehara, K. Noda Japan 4.152 THE EFFECT OF NICOTINIC ACID/LAROPIPRANT ADMINISTRATION ON THE LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) ACTIVITY IN PATIENTS WITH MIXED DYSLIPIDEMIA A. Kei, E. Liberopoulos, K. Tellis, C. Rizos, A. Tselepis, Moses Elisaf Greece 4.153 REGIONAL CORRECTION IN WAIST CIRCUMFERENCE EVALUATION NEEDED IN LATVIA Inga Stukena, A. Kalvelis, G. Bahs, I. Skuja, A. Lejnieks Latvia 4.154 BONE MARROW-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CRITICAL LIMB ISCHEMIA Evgeny Shlyakhto, V. Vavilov, A. Zaritskey, D. Polyntsev, P. Kruglyakov, A. Krylov, I. Senchik, A. Krutikov Russia 4.155 CARDIOVASCULAR RISK PROFILE IN NONOBESE AND OBESE HYPERTENSIVE ADOLESCENTS. STUDY BASED ON BIOMARKERS AND ULTRASONOGRAPHIC ASSESSMENT OF EARLY ATHEROSCLEROSIS Barbara Głowińska-Olszewska, W. Łuczyński, J. Tołwińska, A. Bossowski Poland 136 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) 4.156 SAFETY AND EFFICACY OF NCX 6560, A NITRIC OXIDE (NO)-DONATING ATORVASTATIN, IN A FIRST-INTO-MAN RANDOMISED, DOUBLE-BLIND, PLACEBOAND ACTIVE-CONTROLLED STUDY Pascal Pfister, J. Djian, T. Ferreira, R. Maucci, J. Croizier, P. Tocchetti, L. Gheyle, S. Mesens France 4.157 ADDITIONAL EFFECTIVENESS OF EZETIMIBE CO ADMINISTERED WITH ATORVASTATIN IN HIGH RISK PATIENTS WITH CORONARY HEART DISEASE AND HYPERCHOLESTEROLEMIA Kakha A. Nadaraia, N.N. Kipshidze, T.A. Gegenava Georgia 4.158 EPICARDIAL FAT AND A RISK OF CORONARY ATHEROSCLEROSIS Galina Chumakova, N. Veselovskaya, A. Kozarenko, O. Gritsenko Russia 4.159 CANNABINOID RECEPTOR 1 DOES NOT CORRELATE WITH PERIADVENTITIAL FAT ADIPONECTIN AND VISFATIN EXPRESSION IN AORTIC AND CORONARY ATHEROSCLEROTIC LESIONS Sofia G Spiroglou, C.G. Kostopoulos, P.P. Keryttopoulos, J.N. Varakis, H.H. Papadaki Greece 4.160 VALUE OF THE HYPERURICAEMIA IN PATIENTS WITH CHRONIC HEART FAILURE Vera Larina, B. Bart Russia 4.161 THE EFFECT OF ROSUVASTATIN ON NEOANGIOGENESIS, NITROSATIVE STRESS AND INFLAMMATION IN PATIENTS WITH MULTIFOCAL ARTERIAL DISEASE Y.V. Shchukin, E.I. Seleznev, Elena Alexandrovna Medvedeva Russia 4.162 CARDIOVASCULAR RISK FACTORS MANAGEMENT IN PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE IN THE RUSSIAN FEDERATION (THE EURIKA STUDY) Sergey Boytsov Russia 4.163 TOBACCO CESSATION CLINIC AND WHO'S MPOWER POLICIES A. Aggarwal, S. Dwivedi, Piyush Jain India 4.164 IMPACT OF ASPIRIN RESISTANCE ON ONE YEAR´S PROGNOSIS IN CHRONIC STABLE ANGINA IN SEMNAN - IRAN Rahimeh Eskandarian, M. Darabian Iran 137 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: NEW CHALLENGES AND TARGETS OF CARDIOVASCULAR PREVENTION AND TREATMENT (contd.) Poster No 4.165 PHARMACOLOGICAL CORRECTION OF THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME IN PATIENTS WITH ATHEROSCLEROSIS Ketevan Tamazi Kapanadze, M. Rogava, T. Bochorishvili, E. Berberashvili, G. Sukoyan, K. Bokuridze Georgia 4.166 REAL WORLD 12 MONTH EVALUATION OF VARENICLINE THERAPY J. Shand, Andrew Howe, N. Cinnamond, S. Hussey, I.B. Menown UK 4.167 PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA IN LDL APHERESIS HAVE FREQUENT SIDE EFFECTS ALTHOUGH PATIENT SATISFACTION IS HIGH Anders Hovland, T. Enebakk, R. Hardersen, T.E. Mollnes, K.T. Lappegård Norway Diagnosis, Prevention and Treatment of Cardiovascular Disease WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING 4.168 WESTERN TYPE DIET INDUCES ENDOTHELIAL DYSFUNCTION IN WILD-TYPE MICE: AN 18F-FDG PET STUDY OF THE MOUSE AORTA Anne Mette Fisker Hag, S.F. Pedersen, A. Kjaer Denmark 4.169 PERICARDIAL FAT INFLAMMATION IN PATIENTS WITH ACUTE CORONARY SYNDROME ASSESSED BY 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY Sungeun Kim, E.J. Kim, J.S. Yeo, H.S. Seog Republic of Korea 4.170 CHANGES OF CAROTID INTIMA-MEDIA THICKNESS (IMT) AFTER ADDING EZETIMIBE TO STATIN THERAPY. PROSPECTIVE EVALUATION IN A CLINICAL SETTING Emilio Ros, R. Gilabert, A. Sala-Vila, I. Núñez, M. Doménech, M. Cofán Spain 138 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) 4.171 ANGIOTENSIN CONVERTING ENZYME INHIBITORS EFFECT ON ENDOTHELIAL DYSFUCNTION: A META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS Yousef Shahin, J. Khan, N. Samuel, I. Chetter UK 4.172 GENDER SPECIFIC IMPACT OF INFLAMMATION AND OBESITY ON SUBCLINICAL ATHEROSCLEROSIS IN THE GENERAL POPULATION Suzanne Holewijn, M.D. Heijer, D. Swinkels, A. Stalenhoef, J.D. Graaf The Netherlands 4.173 LOW CAROTID CALCIUM SCORE IS ASSOCIATED WITH HIGHER LEVELS OF GLYCOSAMINOGLYCANS, TNF-ALPHA AND PTH IN HUMAN CAROTID PLAQUES Andreas Edsfeldt, N. Dias, B. Elmståhl, M.F. Müller, K. Berg, M. Nitulescu, A. Persson, O. Ekberg, I. Gonçalves Sweden 4.174 MICROALBUMINURIA, ANKLE-BRACHIAL INDEX (ABI) AND SYSTOLIC HYPERTENSION ARE THE STRONGEST PREDICTORS OF RECURRENT ATHEROSCLEROTIC EVENTS. THE AIRVAG COHORT EXTENDED FOLLOW-UP C. Aranda, M.L. Peralta, I. Gonzalez Anglada, A.I. Huelmos, C. Sanchez, E. Puras, M.L. Casas, L. Lopez Bescos, Carlos Guijarro, The AIRVAG Investigators Spain 4.175 THE ASSOCIATION OF TOBACCO SMOKE WITH SUBCLINICAL ATHEROSCLEROSIS AND ATHEROSCLEROSIS PROGRESSION IS STRONGER IN WOMEN THAN IN MEN Elena Tremoli, F. Veglia, M. Amato, A. Ravani, D. Sansaro, C. Tedesco, A. Discacciati, B. Frigerio, S. Castelnuovo, D. Baldassarre, on behalf of the IMPROVE Study Group Italy 4.176 NOVEL APPROACHES TO PREVENTION OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME Tea Gamezardashvili, N. Kipshidze Georgia 139 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.177 ASSOCIATION BETWEEN HOMEOSTASIS MODEL ASSESSMENT AND CORONARY ARTERY CALCIUM SCORE Hossein Fakhrzadeh, F. Sharifi, Z. Badamchizadeh, M. Ghaderpanahi, M. Mirarefin, A. Mostashfi Iran 4.178 SUBCLINIC ATHEROSCLEROSIS IN A WELL MOLECULAR DEFINED FAMILIAL HYPERCHOLESTEROLAEMIA POPULATION DETERMINED BY AORTIC MAGNETIC RESONANCE IMAGING Nelva Mata, R. Alonso, P. Caballero, P. Rosado, I. Rodriguez-San Pedro, L.J. Jiménez-Borreguero, P. Mata Spain 4.179 NEUROIMAGING ALTERATIONS IN TYPE 2 DIABETES MELLITUS: CORRELATIONS WITH BIOCHEMICAL AND ANTHROPOMETRIC PARAMETERS Natalia García-Casares, M.L. Berthier, J. Rioja, J.A. Garcia-Arnés, A. Gutiérrez, A. Nabrozidis, P. González-Santos Spain 4.180 SIMVASTATIN IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH CARDIOVASCULAR DISEASE BUT NOT IN PATIENTS WITH PERIPHERAL ARTERY DISEASE H. Froehlich, F. Hafner, J. Binder, K. Amrein, H. Scharnagl, M. Brodmann, Tatjana Stojakovic Austria 4.181 THORACIC AORTIC ATHEROSCLEROSIS IN PATIENTS WITH AORTIC REGURGITATION Sara Shimoni, L. Zilberman, S. Goland, O. Edry, J. George Israel 4.182 THE FASTEST PROGRESSION OF CAROTID INTIMA MEDIA THICKNESS IS ASSOCIATED WITH INCREASED VASCULAR EVENTS IN THE IMPROVE STUDY Damiano Baldassarre, F. Veglia, E. Tremoli, on behalf of the IMPROVE Studiy Group Italy 140 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) 4.183 IS FAT IN CARDIOMYOCYTES A COMPONENT OF THE METABOLIC SYNDROME? Marit A. Granér, R. Sirén, J. Lundbom, A. Hakkarainen, M.O. Pentikäinen, K. Nyman, N. Lundbom, M.S. Nieminen, M.R. Taskinen Finland 4.184 C-REACTIVE PROTEIN AS PREDICTOR OF CAROTID INTIMA-MEDIA THICKNESS IN HEALTHY ADOLESCENTS Egle Silva, G. Bermudez, J. Villasmil, L. Chacin, M. Bracho, C. Esis, S. Briceno Venezuela 4.185 ARTERIAL STIFFNESS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IS CORRELATED WITH IMT AND IS DEPENDENT OF TRIGLYCERIDES Sandra Parra, R. Ferré, G. Vives, J. Ribalta, F. Marimon, M. González, A. Castro Spain 4.186 INTIMA-MEDIA THICKNESS CORRELATES WITH FEATURES OF METABOLIC SYNDROME IN YOUNG PERSONS WITH CLINICAL DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLEMIA Barbara Idzior-Walus, M. Walus-Miarka, D. Czarnecka, M. Sanak, B. Katra, E. Wozniakiewicz, P. Miarka Poland 4.187 IMAGING OF NITRIC OXIDE DIRECTLY IN CELLS AND ARTERIES WITH A COPPER (II) FLUORESCENT PROBE AND TWO-PHOTON MICROSCOPY Mitrajit Ghosh, N.M.S.V.D. Akker, C. Weber, D.G.M. Molin, M.A.M.J.V. Zandvoort The Netherlands, Germany 4.188 INCREASING SPATIAL RESOLUTION ALTERS MEASUREMENT VARIABILITY OF CAROTID PLAQUES Diederik F van Wijk, R. Duivenvoorden, D.F. Enklaar, R.J. van der Geest, E. de Groot, E.S. Stroes, A.J. Nederveen The Netherlands 4.189 DEGRADATION OF SPIO INDUCED FERRITIN BY LYSOSOMAL CATHEPSINS, RELATED IMMUNE RESPONSE AND INTERACTION WITH ATHEROMA RELEVANT CELLS Amit Laskar, M. Ghosh, S.I. Khattak, W. Li, X. Yuan Sweden 4.190 FASTEST IMT PROGRESSION: A NOVEL MARKER TO ANALYZE THE EVOLUTION OF CAROTID INTIMA-MEDIA THICKNESS. Fabrizio Veglia, D. Baldassarre, M. Amato, A. Ravani, D. Sansaro, C.C. Tedesco, A. Discacciati, B. Frigerio, E. Tremoli, IMPROVE Study Group Italy 141 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.191 DUAL ENERGY COMPUTED TOMOGRAPHY IMAGING OF ATHEROSCLEROSIS IN A DIET-INDUCED ATHEROMA RABBIT MODEL Eric Lacoste, N. Amalric France 4.192 ASSESSMENT OF AORTIC ELASTIC PROPERTIES IN PATIENTS WITH SARCOIDOSIS Idris Ardic, M.G. Kaya, M. Yarlioglues, H. Buyukoglan, O. Dogdu, M. Akpek, A. Kanbay, C. Bol, I. Ozdogru Turkey 4.193 AMBULATORY BLOOD PRESSURE MONITORING AS PREDICTOR OF SUBCLINICAL ATHEROSCLEROSIS IN ADOLESCENTS Egle Silva, J. Villasmil, L. Chacin, G. Bermudez, A. Gonzalez, M. Bracho, C. Esis, S. Briceno Venezuela 4.194 IMPAIRED AORTIC ELASTIC PROPERTIES IN NORMOTENSIVE PATIENTS WITH PSORIASIS Idris Ardic, M.G. Kaya, M. Yarlioglues, Z. Karadag, A. Dogan, H. Yildiz, O. Dogdu, C. Zencir, E. Aktas, A. Ergin Turkey 4.195 COMPARATIVE EVALUATIONS OF HEART RATE VARIABILITY, QT INTERVAL, TRADITIONAL CARDIOVASCULAR RISK FACTORS AND DISEASE SEVERITY IN PATIENTS WITH RHEUMATOID ARTHRITIS Diana Novikova, T. Popkova, E. Udachkina, A. Volkov, A. Novikov, E. Alexandrova, E. Nasonov Russia 4.196 WIDE EXTENT OF CORONARY CALCIFICATIONS MAY BE COMMON IN CAD HIGHRISK PATIENTS DESPITE NORMAL CORONARY ANGIOGRAPHY Piotr Pysz, J. Dąbek, J. Głogowska-Ligus, M. Sosnowski, Z. Gąsior Poland 4.197 ASSESSMENT OF THE INTIMA-MEDIA THICKNESS OF THE FEMORAL ARTERY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Nelufar Djalilovna Akhmedova, F.A. Rozikhodjaeva, Z. Ikramova Uzbekistan 4.198 IRON STATUS OF CIRCULATING MONOCYTES IS ASSOCIATED WITH IMPAIRED CAROTID ELASTICITY AND ENDOTHELIAL DYSFUNCTION IN HEALTHY MEN OF PRIMARY PREVENTION Pavel J. Kraml, P. Syrovatka, K. Hulikova, J. Potockova, M. Andel Czech Republic 142 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) 4.199 FLOW CYTOMETRY-BASED FUNCTIONAL VALIDATION OF LDLR MUTATIONS FOR AN ACCURATE DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLEMIA A. Etxebarria, L. Palacios, M. Stef, Diego Tejedor, A. Oleaga, L. Irigoyen, B. Torres, H. Ostolaza, C. Martin Spain 4.200 ATRIAL REMODELING AND ARTERIAL STIFFNESS IN THE PATIENTS WITH HYPERTENSION Lucia Agoston-Coldea, T. Mocan, S. Lupu Romania 4.201 COMPARISON OF EFFECTS OF EZETIMIBE ON CAROTID ARTERIAL ELASTIC MODULUS AND C-REACTIVE PROTEIN WITH FLUVASTATIN IN PATIENTS WITH HYPERCHOLESTEROLEMIA Toshio Yamagishi, M. Kato, K. Omata, H. Hasegawa, H. Kanai Japan 4.202 RELATION BETWEEN SUBCLINICAL ATHEROSCLEROSIS AND COMPONENTS OF THE METABOLIC SYNDROME IN HYPERTENSIVE PATIENTS Corina Serban, S. Dragan, I. Mozos, L. Susan, R. Christodorescu, L. Noveanu, A. Pacurari, A. Caraba, R. Mateescu, I. Romosan Romania 4.203 AN ASSOCIATION OF INTIMA-MEDIA THICKENING OF COMMON CAROTID ARTERIES WITH SUBCLINICAL SIGNS OF INSUFFICIENCY OF CEREBRAL BLOOD FLOW T.V. Kirichenko, Veronica A. Myasoedova, D.M. Mironova, I.A. Sobenin Russia 4.204 RISK FACTORS OF CORONARY ARTERY CALCIFICATION IN PATIENTS WITH UNCOMPLICATED ARTERIAL HYPERTENSION SHOWING HIGH COMPLIANCE WITH TREATMENT Irina Shatunova, N.A. Koziolova, I. Lazarev Russia 4.205 AORTIC STIFFNESS IS A DETERMINANT OF CAROTID INTIMA MEDIA THICKNESS IN PATIENTS AT INTERMEDIATE CARDIOVASCULAR RISK Raimon Ferré, J. Merino, N. Plana, M. Heras, C. Buixadera, L. Masana Spain 143 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.206 CAROTID ARTERY DOPPLER IN PREOPERATIVE ASSESSMENT FOR CORONARY REVASCULARIZATION ASSOCIATION OF RISK FACTORS FOR ATHEROSCLEROTIC LESIONS AND CAROTID ARTERY STENOSIS Marzieh Motevalli Iran 4.207 ARTERIAL STIFFNESS IN FAMILIES WITH PREMATURE CORONARY ARTERY DISEASE T Mulders, B. vd Bogaard, A. Bakker, M. Trip, E. Stroes, B. vd Born, S. Pinto-Sietsma The Netherlands 4.208 DOES PRESENCE OF ANTIPHOSPHOLIPID SYNDROME IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS ACCELERATE CAROTID ARTERIES INTIMA MEDIA THICKNESS CHANGES? Aleksandra Djokovic, L. Stojanovich, V. Bisenic, S. Radovanovic, N. Ninkovic, M. Krotin Serbia 4.209 DIAGNOSTIC EVIDENCE OF ACCELERATED ATHEROSCLEROSIS IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME - THE ROLE OF 64 MULTI SLICED COMPUTED TOMOGRAPHY Aleksandra Djokovic, J. Saponjski, L. Stojanovich, D. Mrda, M. Krotin Serbia 4.210 QUANTITATIVE EVALUATION OF EPICARDIAL ADIPOSE TISSUE AFTER ACUTE MYOCARDIAL INFARCTION AND DURING EARLY POSTINFARCTION REMODELLING Margareta Scharin Täng, L. Grip, E. Omerovic Sweden 4.211 LOW-DOSE PRAVASTATIN PLUS EZETIMIBE VERUS STANDARD-DOSE PRAVASTATIN: THE EFFECT ON THE CAROTID ATHEROSCLEROSIS OF PATIENTS WITH HYPERCHOLESTEROLEMIA Yasunori Sawayama Japan 4.212 ELECTROCARDIOGRAM ABNORMALITIES AND CORONARY CALCIFICATION IN POSTMENOPAUSAL WOMEN Siamak Sabour, D.E. Grobbee, A. Rutten, M. Prokop, M.L. Bartelink, Y.T. van der Schouw, M.L. Bots Iran, The Netherlands 4.213 COLOR DOPPLER SONOGRAPHIC FINDINGS OF CAROTID ARTERIES IN RHEUMATOID ARTHRITIS PATIENTS TAKING MEDICAL TREATMENT Abolhassan Shakeri Bavil, A. Khabbazi, M. Babaei Bazzaz, M. Nemati, H. Nosratinia Iran 144 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) 4.214 SERUM LEVEL OF HOMOSYSTEINE IS ASSOCIATED WITH MAXIMUM CAROTID INTIMA MEDIA THICKNESS IN TYPE II DIABETES AND NON DIABETES SUBJECTS Hossein Fakhrzadeh, F. Sharifi, A. Mostashfi, Z. Badamchizade, M. Ghaderpanahi, M. Mirarefin Iran 4.215 THE EFFECT OF AGGRESSIVE CARDIOVASCULAR TREATMENT ON THE PROGRESSION OF CAROTID INTIMA-MEDIA THICKNESS: EXPERIENCE OF AN ATHEROSCLEROSIS PREVENTION CENTER Patrick M Moriarty, C.A. Gibson, J.M. Backes, D. Eldringhoff, S. Powell, J.F. Ruisinger USA 4.216 ACCURACY OF ANKLE-BRACHIAL INDEX MEASURED BY UPPER ARM AUTOMATED BLOOD PRESSURE DEVICES IN PATIENTS WITH DIABETES MELLITUS Javier Ena, T. Lozano, G. Verdu, C.R. Argente, V.L. Gonzalez Spain 4.217 PREVALENCE AND PREDICTORS OF RENAL ARTERY STENOSIS IN HYPERTENSIVE PATIENTS UNDERGOING CORONARY ANGIOGRAPHY Samad Ghaffari Iran 4.218 EVALUATION OF SOME MARKERS OF SUBCLINICAL ATHEROSCLEROSIS IN EGYPTIAN YOUNG ADULT MALES WITH ABDOMINAL OBESITY Manal Mohamed Mahmoud, A.S. Abdu, G.M. Magour Egypt 4.219 ORIGINAL METHOD OF EVALUATION OF ENDOTELIAL DYSFUNCTION BRACHIAL ARTERY Gulnora Rozikhodjaeva, A.M. Ashurmetov Uzbekistan 4.220 IS IT POSSIBLE TO ESTABLISH THE PATHOGENICITY OF MUTATIONS IN THE LDLR GENE WITHOUT FUNCTIONAL STUDIES? L. Palacios, Diego Tejedor, M. Stef Spain 4.221 CLINICAL AND ANGIOGRAPHIC CHARACTERISTICS OF CORONARY ATHEROSCLEROSIS IN INDIGENOUS POPULATIONS (NORTH - EASTERN PART OF SIBERIA) Natalya Makharova, M. Voevoda, L. Pavlov, V. Tarasova, L. Myarina, S. Petrova, M. Tomskij Russia 145 Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No Poster Session Poster Area WORKSHOP: IMAGING TECHNIQUES IN ATHEROSCLEROSIS, DIAGNOSTICS AND PROGRESS MONITORING (contd.) Diagnosis, Prevention and Treatment of Cardiovascular Disease Poster No 4.222 ALTERATIONS IN CUTANEOUS VASOMOTOR RESPONSES AND INFLAMMATORY STATE AFFECTED BY CHRONIC CIGARETTE SMOKING AND AGING Indra Mikelsone, I. Bormane, Z. Simsone, P. Tretjakovs Latvia 4.223 DEVELOPMENT OF GENDER PRESPECIFIED PREDICTIVE MODEL BASED ON BAYESIAN BELIEVE NETWORKS METHOD FOR UNFAVOURABLE OUTCOMES AFTER ACUTE CORONARY SYNDROME I. V. Uporov, I.N. Kurochkin, M.A. Evdokimova, V.V. Nosikov, D.A. Zateyshchikov Russia 4.224 CARDIOVASCULAR RISK FACTORS AND SPECIFIC CORONARY ARTERY CALCIFICATION IN POSTMENOPAUSAL WOMEN Siamak Sabour, M.L. Bartelink, A. Rutten, D.E. Grobbee, M. Prokop, Y.T. van der Schouw, M.L. Bots Iran, The Netherlands 4.225 ROLE OF INTIMA-MEDIA COMPLEX AND ANKLE-BRACHIAL INDEX IN THE EARLY DETECTION OF ATHEROSCLEROSIS IN HIV PATIENTS Carlos Teixeira Brandt, E.T. Godoi Brazil 4.226 NONINVASIVE ASSESSMENT OF LEFT INTERNAL MAMMARY ARTERY GRAFT PATENCY USING TRANSTHORACIC COLOR DOPPLER ECHOCARDIOGRAPHY BEFORE AND AFTER DIPYRIDAMOLE INFUSION Daryoosh Javidi, N. Saffarian Iran 146 79th EAS CONGRESS Gothenburg, Sweden, June 26-29, 2011 Poster Session Poster Area LATE-BREAKING POSTERS Poster No 5.01 ENDOTHELIAL LIPASE (EL) ALTERS CELLULAR LIPID COMPOSITION Monika Riederer, H. Köfeler, M. Lechleitner, M. Tritscher, S. Frank Austria 5.02 PATIENTS WITH ACUTE CORONARY SYNDROME SHOW OLIGOCLONAL T-CELL EXPANSION AND LESIONAL RECRUITMENT OF DIFFERENT T LYMPHOCYTE SUBTYPES Susanne Wangler, T.J. Dengler, J. Haas, B. Wildemann, D. Böckler, H.A. Katus, C. Erbel Germany 5.03 MICRORNA 302A IS A POTENTIAL MODULATOR OF CHOLESTEROL EFFLUX IN MACROPHAGES S. Meiler, E. Toulmin, K. Seng, E. Collier, William A. Boisvert USA 5.04 DECREASED CIRCULATING FIBROCYTE NUMBER CONTRIBUTES TO ATHEROSCLEROTIC PLAQUE INSTABILITY Lu Fang Australia 5.05 IN VIVO MRS ANALYSIS OF NON-ALCOHOLIC FATTY LIVER DISEASE IN A TRANSLATIONAL MODEL FOR THE METABOLIC SYNDROME José WA van der Hoorn, R.A. van de Molengraaf, R. Nachabe, J. Pikkemaat, M. Vlaming, C.F. Sio, R. Lamerichs, J. Degroot, O.C. Steinbach The Netherlands 5.06 PHYTOSTEROL SUPPLEMENTATION DOES NOT AFFECT PLASMA ANTIOXIDANT CAPACITY IN PATIENTS WITH METABOLIC SYNDROME Theodora-Eirini Sialvera, A.E. Koutelidakis, D.J. Richter, G. Yfanti, M. Kapsokefalou, G. Pounis, G. Goumas, E. Diamantopoulos, A. Zampelas Greece 5.07 EXPLORING THE CONTRIBUTION OF PLASMA CETP TO THE MODULATION OF HDL CHOLESTEROL DURING NIACIN ADMINISTRATION IN DIABETIC PATIENTS WITH DYSLIPIDEMIA Themistoklis Tzotzas, S. Karras, T. Gautier, V. Deckert, K. Tziomalos, T. Kaltsas, L. Lagrost Greece 147 June 26-29, 2011 CCIV FINAL PROGRAMME INDEX CCV Ahuja, K. Aihara, K.I. Aishah, N. Akaike, M. Akhmedova, N. Akker, N.M.S. Akpek, M. Åkra, S. Aksu, T. Aktas, E. Ala-Korpela, M. Alavantic, D. Alavi-Majd, H. Alavy, Lutfullaevich, A. Al-Busaidi, A. Alcolak, E. Aldover-Macasaet, E. Alegret, J.M. Aleixo, A. Alekberova, Z. Alekseeva, G. Alexanderson, C. Alexandrova, E. Alexescu, T. Alexiou, E. Alexopoulou, L. Alférez, M.J. Alhusain, A. Ali, A. Alipour, A. Alizadeh, S. Allaert, F.A. Alm, R. Alonso, R. Alonso-Villaverde, C. Alqub, M. Altieri, P. Alugishvili, M. Alvarado-Castillo, C. Alvarez-Sala, L.A. Alves, A. Alves, R. Alves, S. 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