Axsun Swept Laser Engine

Axsun Technologies Inc.
Swept Laser based OCT Subsystems
May 2012
Outline
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Axsun Overview
Axsun Technology and Manufacturing
Axsun Swept Laser Engine products
Product Roadmap
Images
Summary
Axsun Technologies Inc.
AXSUN MODULE ASSEMBLY FACILITY
Optical Engine
•
A wholly owned subsidiary of Volcano
Corporation (Nasdaq: VOLC)
•
Founded in 1998, located in Billerica, MA
•
Producing more than ten thousand
optical engines annually into Telecom,
Industrial Spectroscopy and Medical
Imaging applications
•
Unique tunable MEMS and optical
integration technology
•
Telecom and Industrial products have
strong synergy with Medical Imaging
•
115 employees
•
104 Issued Patents
MEMs Technology and
Manufacturing Platform
High Capacity, Automated
Manufacturing
5
The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices
Optical Bench
Optical Engine
Module
Complete Subsystem
The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices
Optical Bench
Optical Engine
Module
Complete Subsystem
The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices
Optical Bench
Optical Engine
Module
Complete Subsystem
The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices
Optical Bench
Optical Engine
Module
Complete Subsystem
Swept Source OCT
Axsun Swept Laser Technology
and Performance
10
Optical Coherence Tomography
SSOCT
OCT Techniques
1. Time-domain OCT
2. Frequency-domain OCT
• Spectral-domain OCT
• Swept-source OCT
Swept-Source OCT advantages
– Enables balanced and polarization diverse detection
schemes
– Longer Wavelengths, such as 1060 and 1300 nm, enable
deeper penetration into tissue
– Increased imaging depth range from slower signal roll-off
– High SNR and Resolution in a compact, rugged package
#11
Axsun MEMs External Cavity Tunable Laser
Tunable FP Filter
Lens Gain Lens
SOA
Laser Cavity
14 mm
#12
Fiber
Reflector
Output
Optical
Fiber
Micro-Electro-Mechanical System
(MEMS) Tunable Filter
MEMS Fabry-Perot Filter Structure
Wafer Scale Processing
Si
HR Coated
Flat Mirror
Optical Cavity
HR Coated Curved
Mirror on Tethered
Membrane
V
Filter Assembly
Electrode Gap
Tethered
Membrane
#13
Micro-Optical Bench Packaging Platform
MEMS tunable filter
Si micro lens
LIGA alignment structure
Output Fiber pigtail
Micro-optical bench
y
x
z
SOA gain chip
Enables the most compact, highest
speed tunable laser for OCT
#14
Microlens

fiber
Axsun Swept Laser
Performance
Axsun Laser Tuning Range (Bandwidth)
BW > 110 nm
BW > 100 nm
#16
Axsun Laser Coherence Length
Operating conditions:
– l ~ 1060 nm
– 110 nm tuning
range
– 100 kHz scan rate
Axsun’s slow signal rolloff enables longer imaging depth
range than competitive swept lasers and Spectral Domain
OCT systems
#17
SNR over Imaging Depth
 Slow SNR rolloff enables
longer imaging depth
range
1060 47kHz
InGaAs Camera
850nm 91kHz
CMOS Camera
#18
Ref:
Benjamin Potsaid, Bernhard Baumann,
David Huang, Scott Barry, Alex E. Cable,
Joel S. Schuman, Jay S. Duker, and
James G. Fujimoto, "Ultrahigh speed
1050nm swept source / Fourier domain
OCT retinal and anterior segment imaging
at 100,000 to 400,000 axial scans per
second," Opt. Express 18, 20029-20048
(2010)
Axsun 1060nm
100kHz Engine
Axsun OCT Engine
Current products
OCT system with Axsun SS Laser +
Axsun Data Acquisition Board
Clock
DAQ Board
Signal
Clock interferometer
Sweep
Trigger
Swept Laser
10
90
Probe
20
80
Balanced
Receiver
50
50
Variable Delay
1060 nm OCT “Engine”
#21
Axsun OCT products
Axsun Swept Laser OEM Engine
Axsun Swept Laser Benchtop
Engine
#22
Axsun Camera Link DAQ Board
Axsun Swept Laser Engine with
integrated DAQ
Axsun OCT Engine Specifications
1310 Swept
Source
Output Power
(Average) (mW)
1060 Swept
Source
Highlights:
•
High output power (15-18 mW with
back trace blanking)
•
> 100 nm tuning range (for imaging
resolution < 8 µm (1060) or 15 µm
(1310) )
18
15
1250-1360
980 – 1100 nm
Sweep Rate (kHz)
50
100
Coherence Length (Round
Trip PL, mm)
13
10
•
> 10 mm long coherence length (for
imaging depth > 5 mm)
K-Clock Depth (Std, mm)
5
3.7
•
K-Clock Frequency (MHz)
130
330
50–100 kHz scan rates (for fast data
acquisition)
Optional
Optional
•
Demonstrated Sensitivity *
(dB)
Compact, reliable, and massmanufacturable
105
102
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Low noise (RIN < 120dBc/Hz)
Power Supply (vDC)
+12
+12
114 x 177 x 58
114 x 177 x 58
lTuning Range (nm)
Balanced Detector
Size (OEM, mm)
#23
OCT System Performance
Sensitivity for 2.5 mW sample power
120
100
Noise
Operating conditions:
Signal
– l ~ 1060 nm
– 110 nm tuning range
– 100 kHz scan rate
– System includes
Axsun BD and DAQ
SNR
80
SNR + Loss
60
dB
40
20
 Shot Noise Limited
sensitivity of 102dB .
0
-20
-40
-60
0.001
0.01
0.1
1
10
Reference Power (uW)
#24
100
1000
10000
Axsun OCT Product
Roadmap
Product Plans
• Axsun’s Core Technology provides distinct advantages in
size, speed, imaging depth range and reliability for our OCT
Engine Products
• In 2012 and beyond, Axsun will build on our technology lead
in Swept Laser Subsystems
– Higher speed, wider bandwidth Swept Laser Engines
– Data Acquisition/Image Processing
• Our value added subsystem products will speed TTM and
allow our OEM customers to focus on their applications
26
Confidential
OCT Product Roadmap – Next Gen Lasers
• 150nm 100kHz 1310nm Engine
– High resolution Anterior segment
imaging
– Endoscopic cancer detection
– Enables higher resolution and
speed
– Targeting similar coherence length
to our 100nm 50kHz 1310 laser (1215mm)
– We can provide equivalent resolution
at 4X speed and 3x Imaging depth of
our competitors
Wider Tuning BW
100nm
150nm
（10kHz)
27
Confidential
Possibilities for Swept Laser
• In addition to higher speed and wider
bandwidth we can provide other
variations on our swept laser
• Longer coherence length for deep
imaging
– May require some tradeoffs in speed and
resolution
OCT Product Roadmap- System Capabilities
• 2 Channel PCIe based DAQ Board
– Specifically designed to work seamlessly
with Axsun 100 and future 200kHz sources
– 2 Channel 500MSPS 12-bit DAQ
– 1024-2048 samples per A scan
– Xlinx Virtex 6 FPGA gives added signal
processing capability
– Image processing (FFT, Pol. Mixing Windowing)
– Image compression
500MSPS PCI DAQ
– Multiple high speed data interfaces
– Ethernet, GBE, RS232, PCI
Standoff
Mtg Hole
(on Engine
and heatsink)
– In house expertise to provide custom
algorithms
– Quick turn customization capability will be
a differentiator and speed TTM for our
customers
7.000”
Engine PCB Outline
0.124
J14
JTAG J12
LED
4.376”
Bracket Cutout region (end view)
ANALOG
VOLTAGE
REGULATORS
(6V, 5VA, 3.3VA
-5V)
SATA
J1
Maxim
ADC
TI ADC
J13
AUX
J15
FAN
J16
PHY
Flash
PHY
DSP
SDRAM
Hand-piece
J11
TI ADC
FRAM
SMA
J10
SATA
J2
Power
J3
USB
J4
CLOCK LOGIC
1Gb
PHY
12V SUPPLY FILTER,
DIGITAL VOLTAGE
REGULATORS
(5VD, 3.3VD, 2.5V,
1V)
Virtex-6
Xilinx
XC6VLX130T1FFG784C
+ Aavid
374324B60023G
(27x27x10mm)
spring-clip
MB
J5
anchor
8 GTXs
RJ-45
J9
(R/A)
Module
F/O
J8
QSFP cage
Molex 0747500021
4
GTXs
JTAG1 J6
Avago
AFBR-79Q4Z
COM
J7
x8 PCIe
Bracket
Mtg Hole
PCB Bracket
Confidential
Strut
Strut
Mtg Hole
29
Customer Input for DAQ
• Preferred interface (PCIEx)
• Signal Processing
– FFTs, Windowing, Filtering, other signal
processing commands
– Does customer want to program their
algorithms
• Other needs
Axsun OCT Real World
Imaging Examples
Enhanced Depth Imaging with Axsun SL
Engine
• SSOCT Imaging of the
entire Anterior Segment,
Kitasato University
showing dynamic
accomodation(1)
12mm
• Full Anterior Segment
Imaging using fast
Optical Switching – Univ.
of Luebeck (2)
1. Biomedical Optics Express Vol 1, Issue 5, Nov. 2010
2. ARVO Meeting, May 2011
32
OCT Images of Anterior Segment at 1310 nm
Images courtesy of Nicolaus Copernicus University, Torun, Poland
OCT image of
an eye after
corneal
transplantation
OCT image of anterior
eye chamber after
corneal transplantation
#33
World Class Retinal Imaging
Image Courtesy of
Topcon
(Healthy Subject)
#34
Retinal Images with 1060nm Axsun
Swept Laser Engine
Images published by Kyoto University and Tokyo Medical and Dental University
#35
Retinal/AS Images with 1060nm
Axsun Swept Laser Engine
Images Generated by Massachusetts Institute of Technology RLE
1
Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to
400,000 axial scans per second 13 September 2010 / Vol. 18, No. 19 / OPTICS EXPRESS 20029
#36
Cornea displacement and ONH Imaging
• Eye displacement with
Swept Laser OCT
– Sample data from NCU
Poland using OCT to
measure Intraocular
pressure with an air puff
system (1)
Dynamic
measurement of
corneal
displacement
from an air-puff
(NCU- Optics
Express)
• Volumetric Optic Nerve
Head Imaging with High
Speed OCT
– Simon Fraser University (2)
1. Optics Express Vol 19, Issue 15, July 2011
2. Biomedical Optics Express Vol.2, #9 August, 2011
Real Time High Speed Volumetric Imaging using
Compressive Sampling OCT (High Speed Optic
Nerve Head Imaging with the Axsun 1060nm Swept
Laser) – Simon Fraser University
37
Doppler Imaging with Axsun SL Engine
• Retinal Blood flow with
200kHz Axsun SSOCT
demonstrated by MIT(1)
• Doppler OCT blood flow
measurement data from
Duke University (2)
MIT Retinal Blood Flow with 200kHz Doppler OCT
– Axsun 1060nm SSOCT
demonstrated a more
than 60% improvement in
Doppler dynamic range
over SDOCT
1. Biomedical Optics Express Vol 2, Issue 6, May 2011
2. Biomedical Optics Express Vol.2, #8 August, 2011
High Velocity Doppler OCT retinal blood flow
comparison of Axsun 1060 SSOCT vs 830nm SDOCT
38
Summary
• Axsun’s Core Technology provides distinct
advantages in size, speed, imaging depth range
and reliability for our OCT Engine Products
• Researchers and OEMs are building a large body
of impressive clinical data showing advantages
from the use of Swept Laser OCT
• Axsun’s Swept Laser OCT Engine products are
leading the way in the next generation of OCT
imaging systems