The AlloSource Way

The AlloSource Way
AlloSource makes the commitment to never
compromise integrity for gain and expediency.
Doing things “The AlloSource Way” means
driving our decisions from a philosophy of
respecting our donors, understanding the needs
of our doctors and providing the best tissue
for our recipients. Our filter of integrity means
our commitment is working with our customers
to doing it right, not just getting it done.
AlloSource
6278 S Troy Cir
Centennial, CO 80111
main
fax
720. 873. 0213
720 .873. 0212
allosource.org
© AlloSource 2012
M1S0946.00 09/2012
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T HE
A L L OSO UR CE
WAY
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DONAT ION
•An unwavering focus on
integrity in all we do
•The only tissue processor and
distributor founded by Organ
Procurement Organizations
(OPOs) for the purpose of
supporting local communities
•Devoted, committed,
humane employees
•Most tissue processed at
AlloSource received from OPOs
•Knowledgeable, technicallyastute processors steadfast
in their drive to produce
quality tissue
•Strict donor criteria developed
by renowned AlloSource Medical
Advisory Board
•A deep respect for our
donors, our customers
and our recipients
•Stringent screening
procedures include:
-- A respectful and in-depth
medical social history
-- Extensive serology testing
•A non-profit organization
that works for the community
– not the shareholders
FROM
DONOR
THE
ALLOSOURCE
WAY
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IN IT IAL T IS S U E
P R O C E S S ING
•Initial physical inspection
and debridement to remove
visibly defective tissue
•Rigorous tissue inspection
to eliminate substandard
tissue and ensure suitability
of tissue to be processed
•Only Sterile or USP 24 Grade
Water used in processing
•ISO Class 5 to 7 clean rooms
•Continuous environmental
monitoring to detect
potential contaminants
-- Physical assessment
DONATION
INITIAL
TISSUE
PROCESSING
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P R E PAR AT IO N
FO R AlloTru e™
C L E A N S IN G
PROCESS
•AlloTrue technology’s
customized cleansing and
reagent administration
based on specific tissue
type and weight
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TH E A l l oTr ue™
C LEA N SI N G
P R OC ESS
P OST
TR EATM EN T/
EX TR A C TI ON
•Reduces bioburden of
the processed tissue
•Utilizes low dose (10-13 kGy),
low temperature irradiation
•Utilizes a combination of treatments
of antibiotics, alcohol, peroxide (cut
tissue only) and multiple water rinses
•Irradiation process gives
tissue a Sterility Assurance
Level (SAL) of 10-6
•Accurate weights obtained
through sophisticated
centrifugation process
•Deep penetrating cleansing with
minimal tissue manipulation
results in microbial inactivation
•AlloTrue’s technology
prevents overexposure to
solutions and temperature
• The process includes:
•Tissue aseptically placed in
air tight ultrasonic canisters,
thereby reducing the risk
of tissue contamination
PREPARATION FOR
ALLOTRUE CUSTOM
CLEANING
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-- Sonication for loosening of bloods and lipids
-- Rotation for even and dynamic distribution of reagents and rinses
-- Temperature control to reduce
the risk of tissue damage
THE ALLOTRUE
CLEANSING
PROCESS
•ISO 11137 Method 2B used
for sterility validation
•Low dose radiation (15kGy)
does not compromise the
mechanical integrity of the allograft tissue1 •Full water immersion extraction
taken, as opposed to batch
swab, to increase accuracy of
microbial presence reading
POST
TREATMENT/
EXTRACTION
TO
RECIPIENT
K.C. McGivray et al. Cell Tissue Bank.
DOI 10.1007/510561-010—9170-2.2009
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