Plenary sessions - Belgian Brain Council

Belgian Brain Congress 2016 MICX Mons, October 8 INVITED SPEAKERS Alban de KERCHOVE d’EXAERDE Senior Research Associate FRS-­‐FNRS Lab of Neurophysiology, ULB Neuroscience Institute Université Libre de Bruxelles, Belgium [email protected] Education 1990-­‐1996 PhD, Lab. of Physiological Biochemistry under the supervision of André Goffeau, Université Catholique de Louvain (UCL), Belgium. 1997-­‐2000 Post-­‐doc at Lab. of Molecular Neurobiology, Pasteur Institute, under the direction of Professor Jean-­‐Pierre Changeux, Paris, France. 2000-­‐2002 Post-­‐doc at the Laboratory of Neurophysiology under the direction of Professor Serge Schiffmann, Faculty of Medecine, ULB. 2002-­‐2013 Research Associate, Fund for Scientific Research, FRS-­‐FNRS, at the Laboratory of Neurophysiology, Faculty of Medecine, ULB. Main areas of interest Basal ganglia, psychiatric diseases (Addiction, ADHD), Motor learning, operant behaviors, optogenetic, pharmacogenetic, mouse transgenesis. Selected Publications -­‐ R. Klink*, A. de Kerchove d’Exaerde*, M. Zoli, and J.-­‐P. Changeux (2001). Molecular and physiological diversity of nicotinic acethylcholine receptors in the midbrain dopaminergic nuclei. J. Neurosci. 21, 1452-­‐
1483. * Both authors contributed equally to this work. -­‐ A. de Kerchove d'Exaerde, J. Cartaud, A. Ravel-­‐Chapuis, T. Seroz, F. Pasteau, L.M. Angus, B.J. Jasmin, J.-­‐P. Changeux, and L. Schaeffer (2002). Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression, EMBO Rep. 3, 1075-­‐1081. 1 -­‐ P.F. Durieux, B. Bearzatto, S. Guiducci, T. Buch, A. Waisman, M. Zoli, S.N. Schiffmann and A. de Kerchove d’Exaerde (2009). D2R-­‐Striatopallidal neurons inhibit locomotor and drug reward processes. Nat. Neurosci. 12, 393-­‐395. -­‐P.F. Durieux, S.N. Schiffmann and A. de Kerchove d’Exaerde (2012). Cell-­‐type-­‐specific loss in the striatum reveals differential regulation of motor control and response to dopaminergic drugs by D1R-­‐ and D2R-­‐
neurons in distinct dorsal striatum subregions. EMBO J. 31, 640-­‐53. -­‐S.L. Ena, J.F. De Backer, S.N. Schiffmann and A. de Kerchove d’Exaerde (2013). FACS-­‐array profiling identifies Ecto-­‐5’ nucleotidase as a striatopallidal neuron-­‐specific gene involved in striatal-­‐dependent learning. J. Neurosci. 33, 8794-­‐8809. Bénédicte DUBOIS Head of the Laboratory for Neuroimmunology, KU Leuven
Acting Head of the Department of Neurology, University
Hospitals Leuven
[email protected]
Studies • Medical Doctor: University of Leuven, Belgium, 29-­‐06-­‐1994, Summacum Laude • Doctor in Medical Sciences: The disease-­‐promoting role of gelatinase B/MMP-­‐9 in inflammation of the central nervous system (November 2000) Stay abroad Honorary Clinical Assistant to Prof. A.J. Thompson, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, December 1, 2000-­‐September 30, 2001 Current clinical activities • Neurologist at the Department of Neurology, University Hospitals Leuven, Leuven, from October 1, 2001-­‐ ongoing; special interest for MS and other inflammatory diseases • Acting Head of the Department of Neurology, University Hospitals Leuven, Leuven, from December 1, 2013 Scientific work • Clinical trials in multiple sclerosis: Principal investigator of > 20 clinical trials, supported by the industry: administration and evaluation of new drugs • Publications: selected from > 85 articles Goris, A., Pauwels, I., Gustavsen, M.W., van Son, B., Hilven, K., Bos S.D., Celius, E.G., Berg-­‐Hansen, P., Aarseth, J., Myhr, K.M., D'Alfonso, S., Barizzone, N., Leone, M.A., Martinelli Boneschi, F., Sorosina, M., Liberatore, G., Kockum, I., Olsson, T., Hillert, J., Alfredsson, L., Bedri, S.K., Hemmer, B., Buck, D., Berthele, A., Knier, B., Biberacher, V., van Pesch, V., Sindic, C., Bang Oturai, A., Søndergaard, H.B., Sellebjerg, F., Jensen, P.E., Comabella, M., Montalban, X., Pérez-­‐Boza, J., Malhotra, S., Lechner-­‐Scott, J., Broadley, S., Slee, M., Taylor, B., Kermode, A.G., Gourraud, P.A.; International Multiple Sclerosis Genetics Consortium, Sawcer, S.J., Andreassen, B.K., Dubois, B., Harbo, H.F. (2015). 2 Genetic variants are major determinants of CSF antibody levels in multiple sclerosis. Brain, 138(3):632-­‐43. International Mutiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2 (2011). Genetic risk and a primary role for cell-­‐mediated immune mechanisms in multiple sclerosis. Nature, 476 (7359), 214-­‐219. Roxburgh, R., Seaman, S., Masterman, T., Hensiek, A., Sawcer, S., Vukusic, S., Achiti, I., Confavreux, C., Coustans, M., le Page, E., Edan, G., McDonnell, G., Hawkins, S., Trojano, M., Liguori, M., Cocco, E., Marrosu, M., Tesser, F., Leone, M., Weber, A., Zipp, F., Miterski, B., Epplen, J., Oturai, A., Sorensen, P., Celius, E., Lara, N., Montalban, X., Villoslada, P., Silva, A., Marta, M., Leite, I., Dubois, B., Rubio, J., Butzkueven, H., Kilpatrick, T., Mycko, M., Selmaj, K., Rio, M., Sa, M., Salemi, G., Savettieri, G., Hillert, J., Compston, D. (2005). Multiple sclerosis severity score -­‐ Using disability and disease duration to rate disease severity. Neurology, 64(7), 1144-­‐1151. Dubois, B., Leary, S., Nelissen, I., Opdenakker, G., Giovannoni, G., Thompson, A. (2003). Serum gelatinase B/MMP-­‐9 in primary progressive multiple sclerosis patients treated with interferon-­‐beta-­‐1a. Journal of neurology, 250(9), 1037-­‐1043. Dubois, B., Masure, S., Hurtenbach, U., Paemen, L., Heremans, H., van den Oord, J., Sciot, R., Meinhardt, T., Hämmerling, G., Opdenakker, G., Arnold, B. (1999). Resistance of young gelatinase B-­‐deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. Journal of Clinical Investigation, 104(11), 1507-­‐1515. PIERRE THOMAS Université de Lille Pôle de Psychiatrie CHRU de Lille SCAlab CNRS 9193 Lille, France pierre.thomas@chru-­‐lille.fr Pierre Thomas is Professor of Psychiatry at the School of Medicine, University of Lille, France, He is the Clinical Manager of the University Psychiatric Department in Lille. He is the scientific chairman of the Northern France Mental Health Research Federation. He is the Research Director of the “PsycHIC” in the SCALab in Lille. The current research interests of his team cover the neural an psychological processes involved in abnormal beliefs associated with hallucinations, illusion or ideations in psychiatric disorders. He is the president of the French National Academic College of Psychiatry. DemeulemeesterM ; KochmanF ; FligansB ; TabetAJ ; ThomasP ; Jardriet al. , Assessing early-­‐onset hallucinations in the touch-­‐screen generation., Br J Psychiatry, 2015, 206, 181-­‐3 ( IF: 7,9) AmellerA ; DereuxA ; DubertretC ; VaivaG ; ThomasP ; Pins et al. , 'What is more familiar than I? Self, other and familiarity in schizophrenia.,Schizophr.Res.,2015,161,501-­‐5 (IF:3,9) RollandB ; AmadA ; PouletE ; BordetR ; VignaudA , et al. , Resting-­‐state functional connectivity of the nucleus accumbens in auditory and visual hallucinations in schizophrenia., Schizophr Bull, 2015, 41, 291-­‐9 AmadA ; CachiaA ; GorwoodP ; PinsD ; DelmaireC ; Rollandet al. , The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations., Mol. Psychiatry, 2014, 19, 184-­‐91 Jardri, R ; Pouchet, A ; Pins, D ; Thomas, P , Cortical activations during auditory verbal hallucinations in schizophrenia: a coordinate-­‐based meta-­‐analysis., Am J Psychiatry, 2011, 168, 73-­‐81 3 Kees VAN HEERINGEN Director, Unit for Suicide Research Depatment of Psychiatry and Medical Psychology Ghent University, Belgium [email protected] Short CV Kees van Heeringen, MD PhD, is a full professor of psychiatry at the University of Ghent. He is the chair of the Department of Psychiatry and Medical Psychology at the Faculty of Medicine and Health Sciences, and Director of the Unit for Suicide Research at the University of Ghent. He is a fellow at the International Academy for Suicide Research and a member of national and international advisory boards, working groups and associations related to suicide research and prevention. He has published more than 150 scientific papers and 8 books. His research covers three areas in suicidology: epidemiology (e.g. monitoring of attempted suicide, survey studies), neurobiology (e.g. neuropsychology and neuroimaging) and prevention (development and testing of preventive interventions). Selection of 5 publications : 1) The neurobiology of suicide. van Heeringen K, Mann JJ. The Lancet Psychiatry. 2014 Jun;1(1):63-­‐72. Review. 2) Suicide Hawton K, van Heeringen K. The Lancet 2009;373: 1372-­‐1381. 3) Is there a neuroanatomical basis for the vulnerability to suicidal behavior? A coordinate-­‐based meta-­‐
analysis of structural and functional MRI studies. Van Heeringen K, Bijttebier S, Desmyter S, Vervaet M, Baeken C. Frontiers in Human Neuroscience 2014; 8:e824. 4) Suicidal brains: a systematic review of brain imaging studies in association with suicidal behaviour. Van Heeringen K, Bijttebier S, Godfrin K. Neuroscience and Biobehavioral Reviews 2011; 35: 688-­‐698. 5) Pharmacological interventions for self-­‐harm in adults. Hawton K, Witt K, Taylor Salisbury TL, Arensman E, Gunnell D, Hazell P, Townsend E, van Heeringen K. Cochrane Database Systematic Reviews 2015, Jul 6;7:CD011777. doi: 10.1002/14651858.CD011777. 4 Jean-­‐Pierre BOURGUIGNON Professor emeritus, Department of Pediatrics, CHU and Developmental Neuroendocrinology unit GIGA Neurosciences, University of Liège [email protected] RESEARCH INTERESTS
J-P. Bourguignon is a translational researcher with the neuroendocrine control of puberty as primary
focus. His work has contributed to deciphering some physiological neuroendocrine mechanisms of
sexual maturation. He has extended his studies to the role of endocrine disrupting chemicals. His
research projects aim at the effects of fetal and neonatal exposure to endocrine disrupters on
homeostasis of reproduction and energy balance. He is author or co-author of 135 publications in
internationalpeer-reviewed journals.
CLINICAL EXPERTISE AND OTHER ACTIVITIES
His clinical practice bears on pediatric endocrinology with special emphasis on disorders of puberty
and adolescence. J-P. Bourguignon is co-chair of an Endocrine Society task force advocating for
incorporation of the data from endocrine science into regulatory management of chemicals.
LIST OF 5 SELECTED PUBLICATIONS 1
2
3
4
Parent AS, Teilmann G, Juul A, Skakkebaek N, Toppari J, Bourguignon JP. The timing of normal puberty and the age limits of sexual precocity : variations around the world, secular trends and changes after migration. Endocr Rev, 2003, 24 (5): 668-­‐693 Diamanti-­‐Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC. Endocrine-­‐disrupting chemicals : an Endocrine Society scientific statement. Endocr Rev, 2009, 30:293-­‐342 Franssen D, Ioannou YS, Alvarez-­‐Real A, Gerard A, Mueller JK, Heger S, Bourguignon JP, Parent AS. Pubertal timing after neonatal diethylstilbestrol exposure in female rats: neuroendocrine versus peripheral effects and additive role of prenatal food restriction. Reprod Tox 2014;44:63-­‐72 Naveau E, Gérard A, Pinson A, Nguyen L, Thomé JP, Bourguignon JP, Parent AS. Alteration of rat fetal cerebral cortex development after prenatal exposure to polychlorinated biphenyls. PLoS One. 2014 Mar 18;9(3):e91903 Parent AS, Franssen D, Fudvoye J, Gérard A, Bourguignon JP. Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents. Front Neuroendocrinol 2015, 38 :12-­‐36 5 Claudio L. BASSETTI Full Professor and Chair, Neurology Department Inselspital University Hospital 3010 Bern, Switzerland [email protected] Curriculum 1985 Medical degree (MD), University of Basel 1985-­‐6 Research fellow (experimental neurophysiology), Physiology Dept., Basel 1988-­‐1992
Neurology residency, University Hospitals, Bern and Lausanne (FMH 1992) 1992-­‐2001
Attending physician, Neurology Dept., University Hospital (Inselspital), Bern 1995-­‐6 Research fellow (sleep), Neurology Dept., Michigan Un. Hospital, Ann Arbor-­‐MI (USA) 1997
Venia docendi (associate professor) in neurology, University of Bern 2001-­‐2009 Professor and Vice-­‐Chair, Neurology Dept., University Hospital, Zurich 2009-­‐2011
Founder/1st Director, Neurocenter of Southern Switzerland, Lugano 2012-­‐ Full Professor of Neurology and Chair, Neurology Dept., University Hospital, Bern Expertise Clinically general neurology, sleep, stroke, movement disorders Scientifically sleep, stroke, human and animal research Publications Articles: 360; Books: 8; Citation index: 9820; H-­‐Index: 52. Five representative publications
6 Massimo PANDOLFO Head of Neurology department at Erasmus University Hospital Université Libre de Bruxelles 1070 Bruxelles [email protected] EDUCATION/TRAINING
INSTITUTION AND LOCATION
DEGREE
FIELD OF STUDY
YEAR(s)
University of Milan, Italy
University of Milan, Italy
University of California, Irvine
MD
Residency
Post-Doc
1974-80
1980-84
1986-88
Medicine
Neurology
Molecular Genetics
Faculty positions:
2001 - Chief of Neurology, Erasme Hospital, and Professor of Neurology, Brussels Free University (ULB),
Brussels, Belgium
1996 - Adjunct Professor, McGill University, Department of Neurology and Neurosurgery, Montreal,
Canada.
1996 - 2001 Professeur Agrégé (Associate Professor), Université de Montréal, Department of Medicine,
Montreal, Canada.
1994 - 1996 Assistant Professor of Neurology, Baylor College of Medicine, Houston, TX.
1988 - 1993 Assistente Medico di Neurologia (Asssitant Professor), Division of Biochemistry and
Genetics of the Nervous System, National Neurological Institute “C. Besta”, Milan, Italy.
Distinctions
2015 - 2017
2014 2014 2013 - 2017
2012 - 2013
2006 -
Chair, Translational Neuroscience Subcommittee, American Academy of Neurology
Fellow of the American Academy of Neurology (FAAN)
Treasurer, Belgian Neurological Society
Chair, International Subcommittee, American Academy of Neurology
President, Belgian Neurological Society
Member, Science Committee, American Academy of Neurology
Main domain of research: M. Pandolfo’s carries out basic, translational and clinical research in
neurogenetics, focusing on inherited ataxias and epilepsy.
Publications:
208 peer-reviewed publication in international journals, h-index (Scopus) = 51.
7 Claudia BAGNI Professor Department of Human Genetics/ VIB, KUL, Leuven Department of Biomedicine & Prevention, Tor Vergata University, Rome Department of Fundamental Neuroscience, UNIL, Switzerland [email protected] 1995-­‐1999: Lecturer in Molecular Biology in the Department of Biology, University of Rome, Tor Vergata. 2002-­‐2007: Associate Professor Department of Biology, University of Rome, Tor Vergata. 2008 to now: Professor and Group leader (VIB) at the K University of Leuven, and University of Rome. 2012 to 2014: Director Neurogenetics program at the Center for Human Genetics, K University of Leuven. Fellowships and Awards: NIH-­‐Fogarty International, EMBO LTF and STF, ESF STF, EU Capital Mobility Fellowship, CNR, Queen Elisabeth Foundation Award, Baron van Gysel de Meise Price, Union Chimique Belge 2014, Honorary Member Italian Fragile X Association, EMBO Member. My laboratory aims at understanding the cellular and molecular mechanisms of neuronal synaptic plasticity and at identifying molecular pathways that are impaired in intellectual disabilities such as Fragile X Syndrome, Autism and Schizophrenia using mouse and (recently) fly models as well as patients’samples. 5 Selected publications 1) Pasciuto E, Ahmed T, Wahle T, Gardoni F, D’Andrea L, Pacini L, Jacquemont S, Tassone F, Balschu D, Dotti CG, Vegh Z, D’Hooge R, Müller U, Di Luca M, De Strooper B and Bagni C (2015). Dysregulated ADAM10-­‐
mediated processing of APP during a critical time-­‐window leads to synaptic deficits in fragile X syndrome. Neuron, 87: 382-­‐98. 2) La Fata G, Gärtner A, Domínguez-­‐Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG and Bagni C (2014). “The Fragile X Mental Retardation Protein regulates neuronal multipolar-­‐bipolar transition and affects cortical circuitry in the developing cortex” Nature Neurosci., 17:1693-700. 3) De Rubeis S, Pasciuto E, Li KW, Fernandez E, Di Marino D, Buzzi A, Ostroff LE, Zwartkruis F, Klann E, Komiyama NH, Grant S, Achsel T, Posthuma D, Smit AB and Bagni C (2013). CYFIP1 co-­‐ordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation. Neuron. 79 :1169-­‐82 4) Napoli I, Mercaldo V, PiloBoyl P, Eleuteri B, Zalfa F, DeRubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-­‐Mattioli M, Sonenberg N, Achsel T and Bagni C (2008). The Fragile X Mental Retardation Protein represses activity-­‐dependent translation through CYFIP1, a new 4E-­‐BP”. Cell, 134:1042-­‐54. 5) Zalfa F., Eleuteri B., Dickson K.S., Mercaldo V., Di Penta A., Ragnoni S, De Rubeis S, Tabolacci E, Chiurazzi P, Neri G, Grant SG and Bagni C. (2007) “Regulation of PSD-­‐95 mRNA stability: a new function for the Fragile X Mental Retardation Protein”. Nature Neurosci., 10: 578-­‐87. 8 Pieter HOEKSTRA Professor, Department of Child and Adolescent Psychiatry, University Medical Center Groningen, Netherlands [email protected] Dr. Hoekstra’s activities have been directed at neurodevelopmental disorders in children with Tourette
syndrome, attention-deficit/hyperactivity disorder, intellectual disability and/or autism spectrum disorders.
One line of activities concern treatment and clinical studies in this area, regarding psychosocial treatments
for children with behavioural problems, and investigating medication discontinuation and other trials
regarding psychotropic medication. A second line are more fundamental studies, related to the overall topic
of gene*environment interactions, genetics and immunology, mostly in the field of Tourette syndrome but
also childhood aggression as part of several ongoing large scale funded projects (NIMH funded TIC
genetics; EU FP7 funded EMTICS; FP7 Marie Curie ITN TS EUROTRAIN; MATRICS related to
aggression in children; FP7 AGGRESSOTYPE). In the field of ADHD his main line of interest lies in the
field of imaging genetics (NeuroIMAGE project).
Selected publications: 1: van Rooij D, Hartman CA, van Donkelaar MM, Bralten J, von Rhein D, Hakobjan M, Franke B, Heslenfeld DJ, Oosterlaan J, Rommelse N, Buitelaar JK, Hoekstra PJ. Variation in serotonin neurotransmission genes affects neural activation during response inhibition in adolescents and young adults with ADHD and healthy controls. World J Biol Psychiatry. 2015 Oct 1:1-­‐10. 2: Schweren LJ, Hartman CA, Heslenfeld DJ, van der Meer D, Franke B, Oosterlaan J, Buitelaar JK, Faraone SV, Hoekstra PJ. Thinner Medial Temporal Cortex in Adolescents With Attention-­‐
Deficit/Hyperactivity Disorder and the Effects of Stimulants. J Am Acad Child Adolesc Psychiatry. 2015 Aug;54(8):660-­‐7. 3: van Rooij D, Hartman CA, Mennes M, Oosterlaan J, Franke B, Rommelse N, Heslenfeld D, Faraone SV, Buitelaar JK, Hoekstra PJ. Altered neural connectivity during response inhibition in adolescents with attention-­‐deficit/hyperactivity disorder and their unaffected siblings. Neuroimage Clin. 2015 Jan 13;7:325-­‐35. 4: Schweren LJ, Hartman CA, Zwiers MP, Heslenfeld DJ, van der Meer D, Franke B, Oosterlaan J, Buitelaar JK, Hoekstra PJ. Combined stimulant and antipsychotic treatment in adolescents with attention-­‐deficit/hyperactivity disorder: a cross-­‐sectional observational structural MRI study. Eur Child Adolesc Psychiatry. 2015 Aug;24(8):959-­‐68. 5: van der Meer D, Hartman CA, Richards J, Bralten JB, Franke B, Oosterlaan J, Heslenfeld DJ, Faraone SV, Buitelaar JK, Hoekstra PJ. The serotonin transporter gene polymorphism 5-­‐HTTLPR moderates the effects of stress on attention-­‐deficit/hyperactivity disorder. J Child Psychol Psychiatry. 2014 Dec;55(12):1363-­‐71. 9