SILICIUM ORGANIQUE - LLR-G5

SILICIUM ORGANIQUE
G5
®
®
THE SCIENCE
© LLR-G5 2013
1
SILICIUM ORGANIQUE G5®
ORGANIC SILICON G5
®
Established in 1999, LLR-G5 quickly took hold of the Organic Silicon market with its range
of Organic Silicon G5® supplements. LLR-G5 consistently invests in high calibre research
and development of their products. Collaboration with several groups of international
scientists have ensured the advancement of its worldwide reputation and expertise in
Organic Silicon and making LLR-G5 market leaders in Silicon Supplements.
Silicon in the Environment
Silicon is an element of the periodic table
that sits below carbon and has atomic
number 14. Silicon is always found with
oxygen. Together they are the most common
elements in our environment forming over
50% of the elements of the earth’s crust.
Silicon and Health: It’s all about
Connective Tissue Health
Silicon is one of the essential elements of
living materials and, after iron and zinc, is
the third most abundant trace element in
the human body. Silicon is found in all cells
and tissues but is especially prevalent in
connective tissues.
Connective tissue is a vital component
for the health of every organ throughout
the body. Connective tissue makes up
a variety of physical structures including
joints, cartilage, bones, skin (nails and
hair) and blood vessels including the heart.
Therefore, organs require silicon to restore
or conserve their health and equilibrium but
with the ageing process the concentration
of silicon present in the organs diminishes
in a seemingly irreversible manner.
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Dietary Silicon and Connective
Tissue Health
LA
SCU TU
RE
VA
RTILAGE
CA
and its smooth, elastic motion. Collagen
gives strength and flexibility to connective
tissue which, in turn, gives health and
wellbeing to all organs of the body from the
brain through to skin and bones.
Collagen fibres, collagen
structure - intertwined.
ND
IR A SK
IN
HA
BONES
JOINTS
NAILS
What is Silicon actually doing?
Silicon deficiency negatively affects organs
and tissues containing collagen. It’s still
not perfectly understood how or why this
occurs, but the silicon atom appears to
sit inside the collagen, perhaps acting as
‘glue’ for individual collagen fibres. Overall
the collagen structure, like the famous DNA
molecule, is coiled into a ‘spring’, giving
cells and organs their elasticity and easy
gliding movements. Silicon may therefore
be vital to the springy structure of collagen
Procollagen
Subunit
Tripple Helix
(collagen fibril)
Collagen fiber
(collagen bundle)
What real evidence is there to show
that Silicon helps the human body?
Silicon and skin
Scientists have published a great deal of
convincing evidence regarding silicon and
health over the past 50 years. A scientific
study has shown Silicium Organique G5®
© LLR-G5 2014
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SILICIUM ORGANIQUE G5®
gel significantly improves skin health in
®
66%
gel twice
78% of subjects after using G5
Improved
p
y
[1]
daily for 28 days . Specifically: hydration
84%
Improved
p
skin’s brightness
g
%
20
ed hydration
y
40
• The skin’s condition in terms of brightness
and firmness was enhanced82%
in over 80%
Improved
p
skin’s firmness
66%
of subjects.
60
80
100
Improved
p
hydration
y
%
validated skin health questionnaires after
66%
28 days of
regular application of Silicium
Improved
p
y
Organique G5®hydration
gel alongside their regular
84%
skin care regime. The results reported
p
g
above areImproved
all
toskin’s
a brightness
certainty
of greater than
99.9% (ie 82%
p < 0.001).
%
74%
74%
s firmness
s smoothness
84%
MPROVED SKIN’S
BRIGHTNESS
4
74% improved skin’s smoothness
Improved skin’s smoothness
74% improved
skin’s
suppleness
Volunteers
who
reported
improvement
66% improved appearance of skin’s blemishes
64% improvement of skin’s pores
78% overall improvement after using G5® gel
66% improved hydration
84% improved skin’s brightness
82% improved skin’s firmness
• The
pores and blemishes
74% improved skin’s smoothness
Improved skin’s smoothness
improved skin’s suppleness
were reduced in about74%two-thirds
of all
66% improved appearance of skin’s blemishes
64%
improvement
of
skin’s
pores
women.
78% overall improvement after using G5® gel
ed skin’s smoothness
s brightness
g
66% improved hydration
84% improved skin’s brightness
82% improved skin’s firmness
Improved
p
skin’s firmness
74%
skin’s
facial
ation
78% o
Improved
p
skin’s firmness
Improved skin’s smoothness
•66% of 84%
respondents noted
a marked
ed skin’s brightness
g
Improved
p
skin’s brightness
g
increase in the skin’s hydration and a
%
82%
further 74%
in smoothness.
ed skin’s firmness
7
66% im
The study tested the potential benefit of
Silicium Organique G5® gel on the skin
of healthy women. Sixty female subjects
IMPROVED
IMPROVED SKIN’S
IMPROVED SKIN’S
HYDRATION
between
the ages BRIGHTNESS
of 25 and 70FIRMNESS
years
old were studied and all had apparently
healthy skin. The study was designed in
conjunction with, and conducted by, a
global independent research organisation.
IMPROVED SKIN’S
IMPROVED SKIN’S
IMPROVED SKIN’S
FIRMNESS
SMOOTHNESS
SUPPLENESS to
The research
was conducted
according
the Colipa (Cosmetics Europe) guidelines
for the evaluation of the efficacy of
cosmetic products. The female volunteers
completed detailed and independently
66%
82%
84%
74%
82%
74%
66%
84%
82%
IMPROVED
HYDRATION
IMPROVED SKIN’S
BRIGHTNESS
IMPROVED SKIN’S
FIRMNESS
IMPROVED SKIN
SMOOTHNESS
74%
74%
66%
64%
IMPROVED SKIN’S
SMOOTHNESS
IMPROVED SKIN’S
SUPPLENESS
IMPROVED APPEARANCE
OF SKIN’S
BLEMISHES
66%
64%
78%
IMPROVED
LESSAPPEARANCE
VISIBLE
OF
SKIN’S
WRINKLES
BLEMISHES
IMPROVEMENT OF
SKIN’S PORES
OVERALL IMPROVEMENT
AFTER USING
G5® GEL
Ref.1 Allard, S. G5 gel efficacy claims study report. Ayton Global
Research, 2013; United Kingdom.
74%
IMPROVEMENT
SKIN’S PORES
Lassus showed that silicon supplementation
over 90 days of treatment led to a marked
increase in skin thickness and elasticity: i.e.
the skin became more elastic and younger
looking [2]
Again, like dietary silicon, organic silicon
proves beneficial to skin. A study from 2007
shows the elasticity of the skin, i.e. ‘the
youth of the skin’ is also increased when
using MMST compared to a placebo [3].
The study was of the forearms of 7 healthy
volunteers with moderate photoaged skin
using supplemental organic silicon over
10 weeks. An increase in the density of
collagen and elastin fibres in skin with
silicon treatment was shown.
The Relationship between Silicon and Skin
0.24
Epidermal thickness (mm)
Total Skin thickness (mm)
1.5
1.4
1.3
1.2
1.1
1.0
0.9
0.22
0.20
0.18
0.16
0.14
0.12
0
30
60
90
0
Treatment (days)
1.3
60
90
65
1.2
Elasticity Index (%)
Dermal thickness (mm)
30
Treatment (days)
1.1
1.0
0.9
60
55
50
0.8
0
30
60
Treatment (days)
90
0
30
60
90
Treatment (days)
Ref. 2: Lassus J Int Med Res 1993
© LLR-G5 2014
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0.9
0.1
0
30
60
90
Treatment (days)
SILICIUM ORGANIQUE G5®
40
Placebo
Si
20
Elastin Fibers (rel unit)
Collagen Fibers (rel unit)
1.2
1.1
Si
Placebo
0
116
0.9
0
30
112
60
90
Treatment (days)
108
104
100
0
5
10
15
20
25
30
Si intake (mg/day)
Ref. 3: Herreros et al., Arch Dermatol Res 2007
Silicon and Bone
Dietary Silicon Study
In 2004 the world’s top journal for research
into health and disease of bone (JBMR)
published a research article from Harvard
University, Cambridge (UK) and London
(UK) looking at the association between
dietary silicon intake and bone health in
several thousand people [4].
For men and for pre-menopausal women
a marked increase in the density (and
therefore health) of the bone that correlated
to their silicon intake was evident. For post
- menopausal women, there was no such
effect.
6
Men
6
5
5
0.8
96
Elasticity Index (%)
80
60
6
The relationship
between silicon intake and
1.0
bone mineral density
Adjusted BMD (g/cm2) at total HIP
Silicon and Skin health
Dermal thickness (mm)
1.3
Pre-menopausal women
Post-menopausal women
Ref. 4: Jugdaohsingh et al., Journal of Bone and Mineral
Research (JBMR) 2004
Data from Jugdaohsingh et al (JBMR 2004),
showing how the percentage increase in
the bone mineral of the hip (trochanter site)
varies with increasing units of ‘5 mg dietary
silicon’ per day [4].
The apparent ‘block’ for post menopausal
women had been overcome by organic
silicon supplementation in several
previous studies.
The reason for these differences, it turns
out, is due to the presence of the hormone
‘estrogen’. It’s very low levels in post
menopausal women seems to block the
effects of silicon. This study was carried out
using silicon from the diet, and a question
that the researchers have since asked
is whether higher levels of silicon could
overcome this block? In fact, as we shall
see a little later, doctors had already shown
that Organic Silicon did indeed overcome
this block and improved bone mineral
density in older women (and men).
Organic Silicon “MMST”
MMST
Voie orale
As for dietary silicon, strong effects have
been shown in the scientific literature for
the increase in bone density using Organic
Silicon, MMST [4]. Importantly, however,
these effects were also observed in postmenopausal women where dietary silicon
alone failed. Study 1 dates to 1979, which
showed that 70% of subjects increased
their hip bone volume with Organic Silicon
as opposed to a placebo[5].
Placebo
Study 2 also showed a marked increase in
the hip bone density and the vertebrae [6].
MMST
Voie intramusculaire
Increase in bone volume
% change in femoral BMD
5
68.7
3
4.7
2
1
0
-1
(% of patients)
26.7
4
-1.5
Placebo
71.4
Ref. 5: Schiano et al., Revue du Rhumatisme 1979
MMST
-2
Voie intramusculaire
Voie orale
Réf. 6: Eisinger & Clairet Magnesium Res 1993
© LLR-G5 2014
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SILICIUM ORGANIQUE G5®
Organic Silicon: What is it and why
is it special?
Organic Silicon is also commonly referred to
as MMST and is the active moiety of ‘G5®’.
MMST stands for ‘monomethylsilanetriol’.
In fact, the molecule looks very like natural,
dietary derived silicon (which is ‘orthosilicic
acid’) but with one small but important
difference. For Organic Silicon, a hydroxide
group (that is oxygen plus hydrogen) has
been replaced by a methyl group (that is
carbon plus three hydrogens). A simple
chemical representation of the molecule
can be seen below:
The Carbon (C)-Silicon (Si) linkage is
one of very, very high energy and it also
imparts some special characteristics to the
molecule. This can be observed when one
looks at the ‘electric charge’ or ‘energy’
surrounding the MMST molecule.
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On the right side of the above molecule,
the calculated energy field is a mixture of
red (negative charge), green (neutral) and
blue (positive charge): in other words with
varying polarity which makes it look like,
and behave like, water. On the left side of
the molecule, however, the area is all green
(neutral) which means that on this side it
behaves like a lipid (an oil). As a result, this
molecule travels in water and also through
lipid/oil, which is important in the body,
because each cell is made up of 2 things:
water and the lipid membranes around and
in the cell. MMST therefore has the ability to
pass into cells and travel around the body
and so acts as a really efficient delivery
system for silicon. This is referred to as an
‘amphiphilic molecule’*.
Organic Silicon: How well is it
assimilated by the human body?
*Amphiphilic is a term that refers to the ability of
a molecule to be both soluble (dissolved) in water
and oil. It is unusual and allows molecules to travel
through the water based blood stream of the body
but equally across the oil based membranes of cells.
400
Serum Si (µg/L)
However, in its natural environment, the
molecule is surrounded always by water;
the water molecule sits adjacent to the
MMST molecule: they pack together and
therefore the correct concentration and pH
is required to achieve the packing of the
water molecules. In homeopathic medicine,
memory is believed to be carried through
the medium in this fashion.
A comparative study on the absorption
of silicon published in the British Journal
of Nutrition, and carried out on human
volunteers at St. Thomas Hospital in
London, confirmed the very high bioavailability of Organic Silicon. This study
used Organic Silicon G5®, manufactured by
LLR-G5 and showed that absorption of Si
was high (circa 60% overall and up to 70%
in some individuals)- the variation perhaps
being related to individual’s requirements.
300
200
100
1
2
3
4
5
6
Time (h)
© LLR-G5 2014
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SILICIUM ORGANIQUE G5®
The absorption of Organic Silicon G5®, into
the blood stream, and as shown above, is
considerably higher than for other known
silicon supplements [7]. Indeed, the research
shows the human body assimilates Organic
Silicon G5® at least four times better than
other known supplemental forms. For
example, when Organic Silicon G5® is
compared to Colloidal (Choline Stabilised)
and mineral silica, they in comparison
are poorly absorbed in the body, as they
are made up of mineral particles that are
difficult to break down in the gut. Only
approximately 2% of Mineral Silica is
assimilated and 15% of Colloidal silica is
assimilated. There is also no evidence that
these forms are carried into cells, unlike for
Organic Silicon G5®.
The most recent research from the same
group has shown that Organic Silicon G5®
is not only very easily absorbed by the
body, but also metabolised to biological
silicon (‘orthosilicic acid’).
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Absorption by the human body
% Si absorption
1.2
16.5
64
Réf. 7: Sripanyakorn et al., Bri J Nutr 2009
Silice minérale
Silice colloïdale
LLR-G5
Prior to undertaking this research the
group confirmed the very high purity of
Organic Silicon G5® manufactured by
LLR-G5 Ireland[8]. These latest findings
were presented at the 11th International
Symposium on Metal Ions in Biology and
Medicine in Cambridge in 2011 and will be
published in full in the scientific literature.
References:
1. Allard, S. G5 gel efficacy claims study report.
Ayton Global Research, 2013; United Kingdom.
2. Lassus A. Colloidal silicic acid for oral and
topical treatment of aged skin, fragile hair and
brittle nails in females. Journal of International
Medical Research, 1993; 21(4):209-15.
3. Herreros F, Cintra M, Adam R, Machade de
Moraes A, Konradin M. Remodeling of the
human dermis after application of salicylate
silanol. Archives of Dermatological Research,
2007; 299:141-45.
4. Jugdaohsingh R, Tucker KL, Qiao N, Cupples
LA, Kiele DP, Powell JJ. Dietary silicon intake is
positively associated with bone mineral density
in men and pre-menopausal women of the
Framingham Offspring cohort. Journal of Bone
and Medical Research, 2004; 19:297-307.
5. Schiano A, Eisinger F, Detelle P, Laponche AM,
Brisou B, Eisinger J. Silicum, tissue osseux
et immunité. Revue du Rhumatisme, 1979;
46:483-486.
6. Eisinger J, Clairet D. Effects of silicon, fluoride,
etidronate and magnesium on bone mineral
density: a retrospective study. Magnesium
Research, 1993; 6:247-249.
7. Sripanyakom S, Jugdaosingh R, Dissayabutr
W, Anderson SHC, Thompson RPH, Powell
JJ. The comparative absorption of silicon from
different foods and food supplements. British
Jounal of Nutrition, 2009; 102:825-834.
8. Jugdaohsingh R. Assessment of the toxicology
and safety of chronic monomethyl silanetriol
administration in the rat. 11th International
Symposium on Metal Ions in Biology and
Medicine, 2011; Cambridge.
© LLR-G5 2014
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SILICIUM ORGANIQUE
G5
®
®
LLR-G5 Ltd.,
Golden Mile Ind. Park, Breaffy Rd.,
Castlebar, Co. Mayo, Ireland.
T: +353 94 902 8830 F: +353 94 902 1061
E: [email protected] W: www.llrg5.com
© LLR-G5 2013
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