pharmax trans-dermal pain management creams
Transcription
pharmax trans-dermal pain management creams
Where Nutritional Science Comes to Life. PHARMAX TRANS-DERMAL PAIN MANAGEMENT CREAMS REVOLUTIONARY SCIENCE FOR IMPROVED PATIENT RELIEF NEW NOW AVAILABLE New formats and pack sizes THE EVOLUTION OF TRANS-DERMAL TECHNOLOGY THE DELIVRA™ DIFFERENCE Delivra, a proprietary compound base topical delivery system, combines medicinal ingredients that deeply penetrate into the skin to target affected areas. This new pharma-based technology developed by leading Canadian Molecular Pharmacologist, Dr. Joseph Gabriele, draws on interactions between plant-product substances, human cellular and nerve tissues. Gabriele’s objective was to develop a new method to pain relief as an alternate to oral medications, and with the Delivra technology combining premium grade active ingredients that penetrate deep into the dermis layer; this revolutionary technology is shaping the way healthcare practitioners think about topical pain relief. 2 Joseph Gabriele PhD Joseph Gabriele PhD, is a Molecular Pharmacologist specializing in the field of signal transduction pathways in numerous disease states. His early experience focused on Psychiatry and Behavioural Neurosciences as a research scientist at McMaster University in Hamilton, Ontario. In 1981 Dr. Gabriele received his B.Sc. degree from the University of Toronto and in 2003 was awarded his Masters of Science and PhD degrees from McMaster University. In 2006, Dr. Gabriele received his postdoctoral training on the molecular pharmacological effects of antipsychotic medications in patients with schizophrenia at Queens University, Kingston, Ontario. Dr. Gabriele lectures across North America on molecular pharmacology, specifically, molecular pathways that are affected by pharmacological and natural molecules. His research discovered a revolutionary new technology for the trans-dermal delivery of a natural medication that has the potential to block 5 main pain pathways. A recent double-blind crossover clinical trial has proven both compelling and remarkable; clearly showing significant pain relief at the local level without the use of synthetic pharmacological drugs and avoiding adverse side effects such as gastrointestinal and cardiovascular complications. Dr. Gabriele continues his solid commitment to research in collaboration with an extensive research team developing this unique technology, providing physicians and healthcare practitioners with a powerful tool to deliver medications and natural molecules to the body. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, prevent any disease. The aim of this comprehensive product guide is to assist in building more effective and successful patient treatment strategies. The product guide is to be used as an adjunct to Seroyal Continuing Medical Education and is not intended to be utilized as a diagnostic tool nor replace any other required education. The remedies indicated in this product guide are potent medicines that can have profound therapeutic effects on patients. As with any intervention, the dosage may need to be adjusted for those with chronic conditions, very sensitive individuals and those taking multiple medications. Practitioners are solely responsible for the care and treatment provided to their own patients. The information provided by the speaker or speakers in the Seroyal Continuing Medical Education program together with any written material provided do not necessarily represent the views of Seroyal and are not intended as medical advice or an endorsement of any products. This information is for practitioner use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by the FDA. Copyright © 2014 Seroyal. All rights reserved. No part of this information may be used or reproduced in any form or by any means, or stored in a database or retrieval system, or be distributed or replicated without express permission of Seroyal. Making copies of any part of this information for any purposes other than your own personal use is a violation of copyright law. 2327. Version 6. THE EVOLUTION OF PAIN MANAGEMENT 6X STRONGER THAN COMPETITIVE TRANSPORT TECHNOLOGY Delivery Depth of Naproxen Delivra™ vs Competitor 80,000 73,500 At 24 hours, concentration of Delivra™ is DELIVRA™ COMPETITOR 10,700 10,000 CONCENTRATION (NG/ML) The Subdermal Trials – The Delivra™ base underwent rigorous testing for its depth of penetration as a trans-dermal carrier cream.* The base was mixed with Naproxen (the active ingredient in Aleve®, a drug used for pain relief) and tested for the depth of its reach under the many skin layers and into the active dermis layer. Delivery depth of Naproxen with Delivra compound in comparison to the leading competitor showed a greater pharmaceutical delivery depth of Naproxen to the underlying dermis layer. Delivra™ outperformed the competitor 6.8 to 1. * In vitro studies using reconstructed epidermis Epiderm™ 687% HIGHER 4,000 3,500 3,385 3,000 At 6 hours, concentration of Delivra™ is 123% HIGHER 2,760 2,500 2,000 At 3 hours, concentration of Delivra™ is 1,740 1,500 253% HIGHER 1,000 500 503 688 169 0 1 HR 3 HRS 6 HRS 24 HRS At 1 hour, concentration of Delivra™ is 297% HIGHER CONCENTRATION OF NAPROXEN (TIMED INTERVALS) FEATURE BENEFITS PURIFIED NATURALS INHIBIT 5 PAIN PATHWAYS • GMP/Protein Kinase G Pathway • Protein Kinase C Pathway • Nitric Oxide Pathway • Histamine Pathway • Arachidonic Pathway DERIVED FROM PUREST NATURAL ACTIVES An excellent alternative to wholly synthetic, emollient-based creams, Delivra delivers pure active ingredients processed using CO2 extration and purified by High-Pressure Liquid Chromatography; a technique that separates, identifies and quantifies each component in a mixture. NON-GREASY & NON-STICKY FORMULA Addition of amphiphilic molecules creates a smooth, silky topical cream that’s quickly absorbed • Pleasant odor • Paraben-free • Doesn’t contain solium lauryl sulfate (SLS) or petrolatum • Convenient airless pump extends shelf life and helps control consumption *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 3 ON THE GO? Introducing Pharmax™ Nerve and Pharmax™ Relief in convenient compact snap packs. NEW The transformative and effective pain relief found in Pharmax™ Nerve and Pharmax™ Relief are now available in a convenient new snap pack. Simply fold and squeeze the snap pack to release the amount of cream you need. Whether you release a little or a lot the sachet snaps back to its original shape, safely protecting the remaining contents for next time. Its painless to find relief wherever you are. 4 A Trusted Seroyal Brand 1-888-737-6925 www.seroyal.com/pharmax PHARMAX™ NERVE PHARMAX™ RELIEF Neuropathic pain relief Joint pain relief Temporary relief from symptoms associated with nerve pain, diabetic nerve pain and shingles pain Temporary relief of minor aches and pains associated with simple backaches, sprains and arthritis Natural oils and extracts include: •Capsaicin fruit rich in vitamin A and contains vitamins B6, E, C, riboflavin, potassium and manganese1 •Fenugreek seed assists in healing localized inflammation areas •Rutin an antioxidant and skin-conditioning agent •Acai fruit oil contains omega 3 fatty acids and antioxidants •Green tea leaf extract contains polyphenols, catechins and tannins •Lime oil regulates nerve channel Natural oils and extracts include: •Rutin antioxidant and skin-conditioning agent •Black currant seed oil rich in gamma linoleic acid •Raspberry seed oil includes omega-3 and omega-3 fatty acids •Argan kernel oil highly concentrated natural tocopherols and essential fatty acids •Blue lotus flower extract, Masterwort leaf extract and European elder extract are all rich in flavanoids Now available in a compact snap pack! 2 pack sizes to choose from. Now available in a compact snap pack! 2 pack sizes to choose from. DRUG FACTS Active ingredient Purpose Capsicum (Capsicum annuum L.) 2C . . . . . . . . . . . . . Topical Analgesic DRUG FACTS Active ingredient Purpose Rue (Ruta graveolens) 3X. . . . . . . . . . . . . . . . . . . . . . . . Topical Analgesic Uses Temporary relief from symptoms of n nerve pain n diabetic nerve pain n shingles pain, as per Homeopathic Materia Medica. Uses For the temporary relief of minor aches and pains associated with simple backaches, sprains and arthritis, as per Homeopathic Materia Medica. Warnings For external use only. Do not use n on wounds or damaged skin n with a heating pad When using this product n avoid contact with eyes or mucous membranes n do not bandage tightly n use only as directed Stop use and ask a doctor if n symptoms worsen n symptoms persist for more than 7 days or clear up and occur again within a few days n excessive skin irritation occurs If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Warnings For external use only. Do not use n on wounds or damaged skin n in large quantities, particularly over raw surfaces or blistered areas n with a heating pad n if you are allergic to the Astereae/ Compositae/Daisy family When using this product n avoid contact with eyes or mucous membranes n do not bandage tightly n use only as directed Stop use and ask a doctor if n symptoms worsen n symptoms persist for more than 7 days or clear up and occur again within a few days n excessive skin irritation occurs If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Directions (bottle) n apply a small amount on the affected area 1 to 4 times daily or as recommended by a doctor n children (2 and under): consult a doctor Directions (snap pack) n apply 1.5 g to the affected area n children (under 2 years of age): consult a doctor Inactive ingredients Beeswax, camellia sinensis leaf extract, cetearyl olivate, chlorphenesin,citrus aurantifolia (lime) oil, dromiceius oil, euterpe oleracea fruit oil, glycerin, isopropyl palmitate, leptospermum scoparium oil, peucedanum ostruthium leaf extract, polyacrylate-13, polyisobutene, polysorbate 20, angelica root oil, potassium citrate, purified water, rutin, sambucus nigra flower extract, sodium phytate, sorbitan olivate, xanthan gum Pack Size 2.5 oz (70 g) Cream NEW 14 x 0.05 oz (1.5 g) Snap Pack NEW 50 x 0.05 oz (1.5 g) Snap Pack Product Code TP01-70 TP01-14SACH TP01-50SACH Directions (bottle) n adults and children (2 years and older): apply a small amount on the affected area 1 to 4 times daily or as recommended by a doctor n children (under 2 years of age): consult a doctor Directions (snap pack) n apply 1.5 g to the affected area n children (under 2 years of age): consult a doctor Inactive ingredients Argania spinosa kernel oil, beeswax, benzoic acid, calendula officinalis flower extract, cetearyl olivate, dehydroacetic acid, dromiceius oil, ethoxydiglycol, glycerin, isopropyl palmitate, melaleuca alternifolia (tea tree) leaf oil, nymphaea caerulea flower extract, peucedanum osthruthium leaf extract, potassium citrate, purified water, ribes nigrum (black currant) seed oil, rubus idaeus (raspberry) seed oil, sambucus nigra flower extract, sodium hydroxide, sodium phytate, sorbitan olivate, xanthan gum Pack size 2.5 oz (70 g) Cream NEW 14 x 0.05 oz (1.5 g) Snap Pack NEW 50 0.05 oz (1.5 g) Snap Pack Product Code TP02-70 TP02-14SACH TP02-50SACH *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 5 NEW PHARMAX™ REBUILD Muscle and joint pain relief cream NEW PHARMAX™ FIBRO Muscle pain and fatigue relief cream NEW PHARMAX™ VARICOSE Varicose vein relief cream Temporarily relieves symptoms of arthritis including aching, soreness and minor pain Temporarily relieves symptoms of rheumatism including muscle and joint weakness, stiffness and fatigue Temporarily relieves symptoms associated with varicose veins including stinging, prickling and bruised soreness Natural oils and extracts include: •Rutin an antioxidant and skin-conditioning agent •Arnica flower helps with bruises, injuries of the joints and rheumatism2,3 •Phytosterols promotes protection of skin barrier function, epidermis repair and improving collagen synthesis •Glucosamine hydrochloride amino sugar and precursor to assist in the synthesis of proteins and lipids •Pomegranate pericarp extract an antioxidant and skin-conditioning agent Natural oils and extracts includes: •Capsaicin fruit rich in vitamin A and contains vitamins B6, E, C, riboflavin, potassium and manganese4 •Creatine skin conditioning agent naturally produced in the body from amino acids and assists in energy production of cells •D-Ribose a pentose sugar that assists in cellular energy production •Pomegranate pericarp extract a skin conditioning agent comprised of fatty acids and flavonols Natural oils and extracts include: •Witch Hazel bark used for venous congestion and varicose veins5, 6 •Horse Chestnut seed extract a skin conditioning agent containing anti-inflammatory and antioxidant compounds7 •Rutin an antioxidant and skin-conditioning agent DRUG FACTS Active ingredient Purpose Arnica montana L. 5C HPUS. . . . . . . Topical Analgesic The letters “HPUS” indicate that the component in this product is officially monographed in the Homoeopathic Pharmacopoeia of the United States. Uses Temporarily relieves symptoms of arthritis including aching, soreness and minor pain, as per Homeopathic Materia Medica. Warnings For external use only. Do not use n on wounds or damaged skin n with a heating pad n if you are allergic to plants of the Asteraceae/Compositae/Daisy family When using this product n avoid contact with eyes or mucous membranes n do not bandage tightly n use only as directed Stop use and ask a doctor if n symptoms worsen n symptoms persist for more than 7 days or clear up and occur again within a few days n excessive skin irritation occurs If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Directions n apply 2 pumps (0.08 oz) to the affected area two times daily or as recommended by a doctor n children (2 years and under): consult a doctor Inactive ingredients Butylene Glycol, Carthamus Tinctorius (Safflower) Oleosomes, Cetearyl Olivate, Cetyl Palmitate, Chlorphenesin, Dimethyl Isosorbide, Ethoxydiglycol, Ethylhexylglycerin, Glucosamine HCl, Glycerin, Lecithin, Phytosterols, Propylheptyl Caprylate, Punica Granatum Pericarp Extract, Rhus Verniciflua Peel Wax, Ribes Nigrum (Black Currant) Seed Oil, Rutin, Sambucus Nigra Flower Extract, Sodium Citrate, Sodium Stearoyl Glutamate, Sorbitan Olivate, Sorbitan Palmitate, Water, Xanthan Gum Pack Size 2.5 oz (70 g) Cream Product Code TP04H-70 DRUG FACTS Active ingredient Purpose Capsicum annuum L. 5C HPUS. . . . Topical Analgesic Kali phosphoricum 8X HPUS. . . . . . . Topical Analgesic Phosphorus 8X HPUS. . . . . . . . . . . . . Topical Analgesic The letters “HPUS” indicate that the component in this product is officially monographed in the Homoeopathic Pharmacopoeia of the United States. Uses Temporarily relieves symptoms of rheumatism including muscle and joint weakness, stiffness and fatigue, as per Homeopathic Materia Medica. Warnings For external use only. Do not use n on wounds or damaged skin n with a heating pad When using this product n avoid contact with eyes or mucous membranes n do not bandage tightly n use only as directed n transient skin irritation, burning, stinging or redness are part of the normal, expected actions and usually diminish after repeated application Stop use and ask a doctor if n symptoms worsen n symptoms persist for more than 7 days or clear up and occur again within a few days n excessive skin irritation occurs If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Directions n apply 2 pumps (0.08 oz) to the affected area four times daily or as recommended by a doctor n children (2 years and under): consult a doctor Inactive ingredients Butylene Glycol, Caprylyl Glycol, Capsicum Frutescens Fruit Extract, Cetearyl Olivate, Cetyl Palmitate, Chlorphenesin, Copernicia Cerifera (Carnauba) Wax, Creatine, Emu Oil, Ethoxydiglycol, Glycerin, Helianthus Annuus (Sunflower) Seed Oil, Inulin Lauryl Carbamate, Isopropyl Palmitate, Lecithin, Leptospermum Scoparium Branch/Leaf Oil, 1-Methylhydantoin-2-Imide, Peucedanum Ostruthium Leaf Extract, Potassium Citrate, Punica Granatum Pericarp Extract, Ribes Nigrum (Black Currant) Seed Oil, Ribose, Rutin, Sambucus Nigra Flower Extract, Sorbitan Olivate, Sorbitan Palmitate, Water, Xanthan Gum Pack Size 2.5 oz (70 g) Cream 6 DRUG FACTS Active ingredient Purpose Hamamelis virginiana L. 5C . . . . Topical Astringent HPUS The letters “HPUS” indicate that the component in this product is officially monographed in the Homoeopathic Pharmacopoeia of the United States. Uses Temporarily relieves symptoms associated with varicose veins including stinging, prickling and bruised soreness, as per Homeopathic Materia Medica. Warnings For external use only. Do not use n on wounds or damaged skin n with a heating pad When using this product n avoid contact with eyes or mucous membranes n do not bandage tightly n use only as directed n in rare cases some people may experience a skin rash Stop use and ask a doctor if n symptoms worsen n symptoms persist for more than 7 days or clear up and occur again within a few days n excessive skin irritation occurs If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Directions n apply 1 pump (0.04 oz) to the affected area once daily or as recommended by a doctor n children (2 years and under): consult a doctor Inactive ingredients Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Arnica Montana Flower Extract, Butylene Glycol, Cetearyl Olivate, Cetyl Palmitate, Chlorphenesin, Citrus Aurantifolia (Lime) Oil, Citrus Limon (Lemon) Fruit Extract, Copernicia Cerifera (Carnauba) Wax, Dicaprylyl Carbonate, Ethoxydiglycol, Glycerin, Lecithin, Peucedanum Ostruthium Leaf Extract, Polyacrylate-13, Polyisobutene, Polysorbate 20, Ribes Nigrum (Black Currant) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Rubus Idaeus (Raspberry) Seed Oil, Ruscus Aculeatus Root Extract, Rutin, Sambucus Nigra Flower Extract, Sodium Phytate, Solidago Virgaurea (Goldenrod) Extract, Sorbitan Olivate, Sorbitan Palmitate, Water, Xanthan Gum Pack size 2.5 oz (70 g) Cream Product Code TP05H-70 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Product Code TP06H-70 PHARMAX™ HEAL Wound healing cream NEW PHARMAX™ COMPOUND BASE Premium trans-dermal delivery system For the relief of wounds, cuts, scrapes, abrasions, minor burns and sunburns Natural oils and extracts include: •Calendula flower extract promotes healthy granulations and rapid healing8 •Rutin an antioxidant and skin-conditioning agent •Manuka branch/leaf oil appears to involve a post-synaptic spasmolytic effect •Sea buckthorn seed oil rich in linoleic and linolenic acid •Red alga extract contains copper sulphate DRUG FACTS Active ingredient Purpose Calendula (Calendula officinalis L.) 3C. . . . . . Antiseptic Uses Topical relief for n wounds n cuts, scrapes and abrasions n minor burns and sunburns, as per Homeopathic Materia Medica. Warnings For external use only. Do not use n in eyes n over large areas of body n longer than one week, unless directed by a doctor n if you are allergic to the Astereae/ Compositae/Daisy family Ask a doctor before use if you have deep or puncture wounds, animal bites or serious burns. Stop use and ask a doctor if n symptoms persist or worsen n a rash or other irritation develops If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Directions n clean the affected area n apply a small amount on the affected area 1 to 3 times daily or as recommended by a doctor n may be covered with a bandage Inactive ingredients Argania spinosa kernel oil, betula alba bark extract, cetearyl olivate, chlorphenesin, citric acid, copernicia cerifera (carnauba) wax, dromiceius oil, ethoxydiglycol, ethylhexylglycerin, glycerin, hippophae rhamnoides oil, isopropyl palmitate, leptospermum scoparium oil, porphyridium cruentum extract, potassium citrate, purified water, rutin, sambucus nigra flower extract, scrophularia nodosa extract, sodium hydroxide, sodium phytate, sorbitan olivate, xanthan gum Pack Size 2.5 oz (70 g) Cream Oil & water micelle formulation •Penetrates deep into the dermis layer Compound base includes •Polyphenols, rutin and its derivatives Compounding Instructions: For healthcare practitioners only. For compounding purposes only. Responsibility for safety, efficacy and quality of the compounded product is assumed by the healthcare practitioner. Base not for resale. Any blend intended for resale must be repackaged into separate container. Utilize the rule of 10: simply wet in solution (e.g. 5% vitamin C in 5% solvent). Once homogenized, add the solution to the 100 g Pharmax base and blend in with a hand blender or ungulator if one is available. Blend until the cream becomes homogenous. The product consistency will result in a finished cream similar to that of Pharmax™ Relief. Vitamins, minerals, melatonin, gaba, amino acids, dextrose – virtually any watersoluble or fat soluble molecules with the exception of large molecules like enzymes – can be blended. INGREDIENTS Sambucus Nigra Flower Extract, Sorbitan Olivate, Dromecius Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Rutin, Beeswax, Cetearyl Olivate, Benzoic Acid, Sodium Hydroxide n for healthcare professionals only Warnings For external use only. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Pack Size 3.4 oz (100 g) Cream 17 oz (500 g) Cream Product Code TP08-100 TP08-500 Product Code TP03-70 REFERENCES: 1. Boericke, W. Pocket Manual of Homeopathic Materia Medica and Repertory, B. Jain Publishers Pvt. LTD, Delhi India. 1995: 167-168. 2. Boericke 76. 3. Kent, JT. Materia Medica of Homeopathic Remedies, Homeopathic Book Service, London. 1989: 145. 4. Boericke 167-168. 5. Boericke 318. 6. Kent 564. 7. Wilkinson JA, Brown AM. Horse Chestnut - Aesculus Hippocastanum: Potential Applications in Cosmetic Skin-care Products. Int J Cosmet Sci. 1999 Dec;21(6):437-47. 8. Boericke 156. *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 7 Where Nutritional Science Comes to Life. To order, call: 1-888-737-6925 [email protected] For more information, visit: www.seroyal.com/pharmax