click here for a pdf version of the official program

“Shifting Paradigms in Heart Development”
Locations
Presentations: BSB-202 2nd floor
Refreshments: Elevator Lobby BSB 6th floor
Wednesday March 19
10:30 – 12:15
11:30 – 12:15
REGISTRATION (in BSB 6th floor Lobby)
SPEAKERS LUNCH (in BSB656)
Session 1: Chairs Roger Markwald, Scott Argraves
12:30 – 01:15
01:15 – 02:15
GENERAL INTRODUCTION: Andy Wessels
and
DEDICATION OF THE MOLECULAR MORPHOLOGY & IMAGING CORE
TO THE MEMORY OF JOSH SPRUILL: Roger Markwald
CDBC Lecture: Fred Schoen Harvard Medical School
“Evolving Concepts of Cardiac Valve Dynamics: The Continuum of Development,
Functional Structure, Pathobiology and Tissue Engineering”
02:15 – 03:00 Jonathan Butcher Cornell University
“Mechanoregulation of Valvulogenesis: New Approaches for Old Ideas”
03:00 – 03:30 BREAK
03:30 – 04:15 Corey Mjaatvedt
MUSC
“Versican Splice Form Null Mice Exhibit Heart Defects That Correlate With
Altered Proteomic Profiles”
04:15 – 05:00 Bob Friesel Maine Medical Center Research Institute
“Sprouty Function in Vascular Development”
05:00 – 05:45 Bryan Toole MUSC
“Emmprin, Hyaluronan and CD44: Co-Regulators of Membrane Transporters”
06:30 – 10:00 CDBC RECEPTION: Wickliffe House
Thursday March 20
08:00 – 08:30 BREAKFAST
Session 2: Chairs Tim McQuinn, Rob Gourdie
08:30 – 09:00 Michael O’Quinn MUSC
“A Peptide Incorporating the Zo-1 Binding Domain of Cx43 Improves Recovery
of Cardiac Function Following Injury”
09:00 – 09:45 Vincent Christoffels University of Amsterdam
“T-box Transcription Factors Are Key Regulators of Pacemaker and
Conduction System Development”
09:45 – 10:30 Hans-Georg Simon Northwestern University
“Thinking Inside and Outside the Nucleus: New Roles for the Tbx5 Shuttling
Protein in Heart Development”
10:30 – 11:00 BREAK
11:00 – 11:30
Jennifer Krzmery Northwestern University
“The Role of the Tbx5 Interactor, Lmp4 During Mouse Embryogenesis”
11:30 – 12:15 Anne Moon University of Utah
“Identifying Cellular Targets of Fgf Signaling Required for Outflow Tract
Remodeling”
12:15 – 01:00 Paul Riley University College of London
“Prox1 Function in Cardiac Muscle Ultrastructure and the Developing Valves”
01:00 – 01:30 Loretta Hoover MUSC
“Retinoid Regulation of TGFb-Mediated Smad2 Phosphorylation and
Downstream Signaling”
01:30 - 02:30 Speakers Lunch at BLEND (invitation only)
Session 3: Chairs Steve Kubalak, Kyu-Ho Lee
02:45 – 03:45 Taber Lecture: Cliff Tabin Harvard Medical School
“Patterning and Organogenesis of the Heart and Gut”
(with introduction by Roger Markwald)
03:45 – 04:30 Maurice van den Hoff University of Amsterdam
“Cardiomyocyte Formation at the Inflow of the Heart”
04:30 – 05:00 BREAK
05:00 – 05:45 Steven Fisher Case Western Reserve School of Medicine
“Hypoxia and Apoptosis-Dependent Remodeling of the Cardiac Outflow Tract”
05:45 – 06:30 Ann Ramsdell MUSC
“Left-right Axis Determination and Cardiac Development”
06:45 – 09:30 TABER RECEPTION: Thomas Bennett House
Friday March 21
08:00 – 08:45 BREAKFAST
Session 4: Chairs Rick Visconti, Christi Kern
08:45 – 09:30 Brenda Rongish University of Kansas
“Computational Imaging of Early Avian Heart Development”
09:30 – 10:00 Brian Snarr MUSC
“The Dorsal Mesenchymal Protrusion, a Second Heart Field Derivative, Plays
an Important Role in AV Valvuloseptal Development”
10:00 – 10:45 Bob Anderson MUSC
“Further Findings Concerning the Development of the Outflow Tract”
10:45 – 11:15 BREAK
11:15 – 12:00 Jose Xavier-Neto University of Sao Paulo
“AP Patterning and the Evolutionary Origin of Cardiac Chambers”
12:00 – 12:45 Louis Polo-Parada University of Missouri
“The Extracellular Matrix Modulates Action Potential Phenotype During
Heart Development”
12:45 – 01:00 CLOSING REMARKS: Andy Wessels
01:00 – 02:00 LUNCH AND ADJOURN
Elsie Taber (1915-2000) graduated from the University of
South Carolina and obtained her master’s degree from Stanford
University. After teaching biology at Greenwood High School and
Lander College she undertook advanced studies at the University of
Chicago where she received the Doctor of Philosophy degree and
served on the faculty. In 1948, she joined the Anatomy Department
of the (then) Medical College of South Carolina, the first woman
to hold a full-time appointment in the medical school. Her career
included pioneering research in the field of growth and development
and endocrinology, her contributions to teaching included the
introduction of human genetics into the basic embryology course
for first year medical students at the College of Medicine. Elsie
Taber made numerous contributions to biomedical literature and
participated in many professional societies, including the American
Association of Anatomists and the American Society of Zoologists. She is listed in Who’s Who of
American Women, Outstanding Educators of America, and American Men and Women of Science.
She received many awards including the coveted Golden Apple Award, given by medical students
for excellence in teaching. The high point came in 1991 when she was awarded the Degree of
Doctor of Humane Letters. Her former students honored her with a portrait which hangs in the main
lobby of the Department of Cell Biology and Anatomy at MUSC, and The Elsie Taber Lectureship in
Human Development. It is a long-standing tradition that the Taber lecture is presented a distinguished
scientist. Past speakers include Dr. Elizabeth Hay (1983), Dr. Beatrice Mintz (1985), Dr. John Fallon
(1996), Dr. Don Fischman (1999), Dr. Antoon Moorman (2000), Dr. Nigel Brown (2001), Dr. Robert
H. Anderson (2002), Dr. Scott Baldwin (2003), Dr. Parker Antin (2005) and Dr. Ray Runyan (2007).
We are pleased and honored to have Dr. Cliff Tabin as our 2008 Taber Lecturer.
This year’s Taber Lecture will be presented by Dr. Cliff Tabin, the
George Jacob and Jacqueline Hazel Leder Professor of Genetics
and Head of the Department of Genetics at Harvard Medical
School. Following seminal work as a graduate student on activating
mutations of the ras oncogene in the laboratory of Robert Weinberg
at MIT and a postdoctoral fellowship in the laboratory of Doug
Melton at Harvard University, Dr. Tabin and his laboratory have
worked steadily to understand pattern formation in the developing
embryo. Starting from groundbreaking work on the role of sonic
hedgehog in determining limb patterning, Dr Tabin, his laboratory
and his trainees have made continuing and essential contributions
to the field of embryology. These include but are not limited to
major insights regarding left-right asymmetry, craniofacial and gut
development, cartilage and tendon formation, evolutionary biology,
and cardiovascular development and pathogenesis. In addition to his considerable research efforts,
Dr. Tabin has devoted a major portion of his time to teaching graduate and medical students, and
towards helping shape widespread educational reform at Harvard Medical School. Recently, Dr.
Tabin has offered his talents and experience on an international stage through his efforts to aid
in the development of a new medical school in Nepal. Dr. Tabin’s continuing contributions to the
fundamental understanding of developmental phenomena and its application to human disease, and
his commitment to the future of medical training and healthcare delivery exemplify in every way the
“Taber spirit.” The title of his Taber Lecture will be: “Patterning and Organogenesis of the Heart and
Gut.”
On February 10th, 2008, our good friend and colleague Josh Spruill passed
away in his sleep. The pain that this very unexpected loss has caused for his
family and close friends, as well as our Department and the MUSC community is
difficult to describe. It is fair to say that Josh was one of the most liked and loved
employees at MUSC. In addition to his many other duties and responsibilities
in the Department of Cell Biology and Anatomy, Josh was an important link in
the organization of the Cardiovascular Developmental Biology Center (CDBC)
Symposia. Not only was he always there to help our guests with computer-related
problems, of which there were many over the years, he also was the driver of the
CDBC Transport Van. During the CDBC Symposia, Josh was always busy picking up and dropping
off participants at the airport, hotels, and restaurants. For more than 12 years, Josh was, together
with his supervisor and friend, Tom Trusk, responsible for maintaining the departmental Molecular
Morphology and Imaging (MMI) core. This facility forms the beating heart of the department and his
efforts to keep it running smoothly for all these years are well recognized. With the above in mind,
it was decided that this year’s CDBC symposium would provide an excellent opportunity to officially
acknowledge everything that Josh has done for us over the years. During a short ceremony at the
opening of the 7th Annual CDBC Spring Symposium at 12:30 PM on Wednesday, March 19, we will
dedicate the Imaging Facility to his memory.