Winter Focus-2003/final - Diabetes Research Institute

Calendar
For information on the events or to make reservations,
please call one of the DRI Foundation offices listed below.
Children’s Best Hope For
New York
A Cure Dinner
March 7, 2003
For the second year, this annual dinner includes
dinner, dancing, silent auction and the Man of
the Year presentation.
Lanie’s Lanes
New York
March 9, 2003
An annual bowl-a-thon held in memory of
Helaine White.
On Target
Florida
March 11, 2003
To be held at the Great House of Quayside, this
dinner reception includes an equipment auction
for the Institute.
DRI Research Update
California
March 12, 2003
To be held at the Radisson Valley Center Hotel
in Sherman Oaks, this free event will feature
presentations by Norma S. Kenyon, Ph.D.
and Ken Bernstein, one of the DRI’s islet cell
transplant recipients.
Party with the Stars
April 5, 2003
Florida
This new Palm Beach County event, featuring
an exciting Hollywood trivia treasure hunt, will
be held at Creations in Delray Beach.
“Donate and Create” Seminar
April 11, 2003
Florida
Join best-selling author and talk show host
Barry Kaye to learn about his unique estate
maximizing techniques at the Renaissance
Boca Raton Hotel.
Crystal Ball
New York
April 12, 2003
To be held at the Garden City Hotel, this
black tie event will have cocktails, dinner
and dancing with live and silent auctions of
extraordinary items.
DRIfocus
Diabetes Research Institute
National Foundation Office
3440 Hollywood Blvd.
Suite 100
Hollywood, FL 33021
www.drinet.org
DRI Research Update
Connecticut
April 13, 2003
DRI scientists will discuss the latest scientific
advancements at this event, to be hosted by
Jed Ringel and his family in Fairfield County.
Cook for the Cure
Alabama
May 2, 2003
Hosted by John Saint and The Mitchell
Company, guests will enjoy a silent auction,
some of the South’s best barbecue and live
entertainment.
Don Strock Diabetes
Florida
Golf Classic
May 21, 2003
Former Miami Dolphin and Head Coach of
the FIU Golden Panthers, Don Strock hosts
this 18-hole golf classic, followed by a cocktail
reception, dinner, and auction at the Miccosukee
Golf and Country Club.
Nationwide
DAD’s Day
June 13 -15, 2003
Spearheaded by the Building and Construction
Trades Department of the AFL-CIO, participants
collect contributions for the DRI through various
fundraising events.
DRI Golf Classic
New York
June 16, 2003
Golf tournament to be held at Fenway Golf Club
in Scarsdale.
Florida
Feast Among the Grapes
June 21, 2003
South Florida’s premier wine and food festival
will be held at the soon-to-open Parrot Jungle
Island. A VIP champagne reception, in honor
of wine connoisseurs and longtime friends of
the DRI Sue and Doug Gallagher, will precede
the main event.
DRIfocus
is a publication of the
Diabetes Research Institute Foundation.
Winter 2003 / Volume 31, Issue 2
Editor Lori Weintraub, APR
Contributors Lauren Schreier, Mitra Zehtab, M.D.
Design Franz Franc Design Group Inc.
Photography Tom Stepp, Pyramid Photographics,
Claude Zick, Foundation Staff & Volunteers
The Diabetes Research Institute Foundation supports
the Diabetes Research Institute at the University of
Miami School of Medicine, whose mission is to
develop and rapidly apply the most promising research
to treat and cure those now living with diabetes.
To obtain additional information or request copies
of DRIfocus, please call (800) 321-3437 or
e-mail [email protected].
Diabetes Research Institute Foundation Offices
National Office
3440 Hollywood Boulevard, Suite 100
Hollywood, FL 33021
Phone: (954) 964-4040 Fax: (954) 964-7036
Northeast Regional Office
11 Penn Plaza, 20th Floor
New York, NY 10001
Phone: (212) 239-2783
Long Island Regional Office
45 Glen Cove Road
Greenvale, NY 11548
Phone: (516) 621-8804 Fax: (516) 621-8501
California Regional Office
3760 Motor Avenue, Suite 314
Los Angeles, CA 90034
Phone: (310) 202-0080 Fax: (310) 202-0081
Alabama Regional Office
3280 Dauphin Street, Suite B127
Mobile, AL 36606
Phone: (251) 479-9961 Fax: (251) 479-6441
Non-Profit
US Postage
PAID
Diabetes Research
Institute Foundation
DRIfocus
Diabetes Research Institute Foundation
Winter 2003 / Volume 31, Issue 2
www.drinet.org
Miami • New York • Long Island • California • Alabama • Washington, D.C.
Researchers, Transplant Patients Inspire Hope
at New York Research Update
“Now I really, truly feel that there
will be a cure after hearing everything
today,” said Laura Billetdeaux of
Children With Diabetes, who traveled
from Manchester, Michigan, to
Manhattan for the DRI Foundation’s
third New York Research Conference.
The scientific advances made in the
last year were also apparent to 27-yearold Benjamin Hatz of Great Neck, New
York, who was diagnosed with Type 1
diabetes at age 10. “The presentations
were very broad-based, and the scientists made it clear that they are really
on the threshold of a number of discoveries, and that this isn’t just hope.”
Billetdeaux and Hatz were among
the 350 people who gathered in the
ballroom of the Grand Hyatt Hotel last
October to hear encouraging updates
from the researchers on hand from the
DRI and other institutions, as well as
a poignant address by one of the DRI’s
transplant patients.
Empire
Ball
Raises a Record $1 Million
story on page 14
address service requested
Comedian Ray Romano offers his support
to the Diabetes Research Institute.
(l-r) Massimo Trucco, M.D., Juan Dominguez-Bendala, Ph.D., Camillo Ricordi, M.D., Norma S. Kenyon, Ph.D., Jay Skyler, M.D.,
and F. Charles Brunicardi, M.D., presented encouraging updates on the progress being made toward a cure.
After a warm welcome by Dr. Denise
Stern, who co-chaired the conference
together with her husband, Thomas Stern,
and Esther and Marc Goodman, each of the
six presenters described the exciting work
underway in their respective disciplines.
Dr. Jay Skyler, professor of medicine,
pediatrics and psychology and director of
the Division of Endocrinology, Diabetes
and Metabolism at the University of Miami,
opened the program with an overview of
autoimmunity, intervention strategies and
new therapies. Dr. Skyler, who also serves as
associate director for academic programs at
the DRI, described a number of intervention strategies that are directed at halting
the complete destruction of beta cells both
prior to and immediately after clinical onset
of the disease. He also explained the
approaches now underway to identify those
at risk for developing Type 1 diabetes with
the goal of preventing the disease.
F. Charles Brunicardi, M.D., the
DeBakey/Bard professor and chairman
of the Michael E. DeBakey Department
of Surgery at Baylor College of Medicine
in Houston, Texas, discussed pathways,
building blocks and new communications
within the pancreas. After providing a
brief history of what has been learned
about the pancreas during the past 100
years, Dr. Brunicardi remarked about
how the development of the Ricordi
Chamber revolutionized the field of islet
cell research.
Much of the progress being made
today, he said, is the result of being part
of a team. Last year, the DRI assisted
Dr. Brunicardi and his colleagues with
the first successful state-to-state islet
transplant. “Through our collaboration,
we have now transplanted five patients,
four of which are off insulin. This is a
remarkable achievement that would
not have been possible without Camillo
Ricordi and the DRI.”
Continued on page 9
Inside focus
Richard H. Kline Leaves a Legacy
3
Foundation Donors Recognized
3
Ramon Poo Recognized for
Outstanding Contributions
4
Focused and Passionate, Jed Ringel
is Just Getting Started
5
Young of Age, Young at Heart,
Wise Beyond Years
6
Silver Ridge Turkey Trot Takes on
a New Tradition
6
Empowering Families at Whats Up Doc?
7
Preview Party Offers a Hint of Things to Come
8
Around the DRI
10
Under the Microscope
With Ricardo Pastori, Ph.D.
11
Alabama Strides for a Cure
12
New York’s Fall Into Fashion
Reaches New Heights
13
Empire Ball Raises a Record $1 Million
14
DRI Golf Classic Swings Another Success
15
Annual DRI Golf Classic
Pays Tribute to Harold Kart
16
A Night to Treasure Bedazzles Broward Set
17
Poker Run Proves it’s All in the Cards
17
A Gift of Love, A Gift of Hope
Honors a Dear Friend
18
Serving Up a Spoonful of Success
18
“Help Find a Cure” Through Internet Connection
19
Foundation Opens
California Regional Office
Richard H. Kline Leaves a Legacy
The DRI Foundation, currently a strong presence in the eastern
U.S. with offices in New York, Alabama, Washington, D.C. and the
national headquarters in Florida, has recently expanded westward.
The newest office, located at 3760 Motor Avenue, Suite 314 in
Los Angeles, opened in November of 2002. Taking the helm,
Mitchell Glickman has been named regional director of the
California branch.
Richard H. Kline was a modest and caring
man with dreams that will continue well
beyond his lifetime. Born in Chicago in
1923, Kline, who was an only child, moved
to Florida at the age of 10 after his mother
and stepfather lost everything during the
depression years. When he was 16, Kline
dropped out of high school and joined
the Navy. He served in World War II and
continued in the service until he developed
diabetes at the age of 29, at which time he
received an honorable discharge.
California Regional Director
Mitchell Glickman
“We have a growing base of supporters, as well as some board
members, on the West Coast. We felt it was necessary to open a regional office in order
to service our many donors there, and attract new people to our organization,” stated
Robert A. Pearlman, president and COO of the DRI Foundation. “Mitchell’s experience
in the nonprofit sector made him a natural fit.”
With over 17 years of experience in nonprofit management, Glickman has a penchant
for starting organizations at the ground level and building them into successful ventures.
Glickman, a graduate of Oberlin College in Ohio, was formerly the executive director of
the Henry Mancini Institute, a pre-profession summer educational program for aspiring
musicians in California. He and partner Jack Elliott developed the company from an idea in
1997 into the thriving entity it is today.
“It was very inspirational to hear how a group of South Florida parents with a common
goal helped build the Diabetes Research Institute into a world leader,” stated Glickman,
who was born and raised in Miami, Florida. “I hope to use my knowledge and experience to
strengthen the infrastructure and make sure the battle to find a cure for diabetes is won.”
Prior to his stint at the Henry Mancini Institute, Glickman served as executive director of
American Jazz Philharmonic and associate director of the New American Orchestra. He
holds a number of record and concert producing credits and has composed and arranged for
a variety of film and television series, including Cheers, Night Court and the Grammy
Awards, among others.
To garner interest, a kick off meeting was held recently at the home of Sandy Fox, member
of the national board of directors. Those individuals who would like to get involved can call
310-202-0080. Once it is completely appointed, the California board of directors will work
with Glickman to develop plans for numerous fundraising events and other activities.
Deborah L. Chodrow Selected to Lead Foundation’s Major Gifts Program
As the DRI continues its
significant progress in islet
transplantation while
launching new programs
focused on the emerging
scientific disciplines of
stem-cell research, signal
transduction and molecular
biology, among others, it is
more critical than ever for
the Foundation to raise the
increased funds necessary to support these cuttingedge initiatives.
Central to meeting its financial obligation is the
Foundation’s ability to attract new donors, and
particularly those who can make a major contribution.
The key to its continued success, and in fulfilling the
DRI’s mission to cure this disease, will be in sustaining
this growth going forward.
In order to effectively carry out its future plans, the
Foundation is pleased to announce the appointment of
Deborah L. Chodrow to the newly-created position of
Vice President of Major Gifts. She will be based out of
the Foundation’s national office in Florida, and will
spearhead the organization’s efforts to identify, inform
and involve those individuals who can participate in the
Foundation’s mission through major contributions.
“I am looking forward to working with this
extraordinary group of people, who are so close to
discovering the cure for this disease,” said Chodrow.
“It is our responsibility to assure these researchers
that funds are available so they can pursue their
important work.”
Chodrow has more than 20 years of high-level
fundraising experience, having spent the last 17 years
in senior management positions at the American
Friends of the Hebrew University, supervising major gifts
2
programs’ regional operations from the national office
in New York, as well as directing fundraising and leadership development activities in the Southeast. During
her tenure, she was professionally responsible for the
American Friends’ major gifts portion of The Hebrew
University’s International Capital Campaign, which
raised over $600 million two years ahead of plan.
The manner in which Kline came into the
pet store business is a heart-warming story,
according to his cousin, Rosalie Metcoff.
Kline was in the VA Hospital as a result
of complications from diabetes. A man
terminally ill with cancer lay in the bed next
to him. The man spoke to Kline about his
concerns for his wife’s welfare and the future
of his pet shop after he was gone. Kline
reassured his roommate that there was no
need to worry. Making good on his promise,
Kline purchased the pet store and provided
for his friend’s wife for the duration of her life.
The pet shop, located in Miami, thrived
under Kline’s ownership, and he shared his
good fortune with numerous philanthropic
organizations. He could never say “no” to a
good cause. After selling the business and
retiring, he moved to Wynmoor Village, a
retirement community in Coconut Creek,
Florida. Having never married, he realized
that plans needed to be made for the distribution of his estate upon his death. He visited
his family in Chicago to determine if any of
his relatives were in need of his support.
Finding that everyone was well taken care of,
he decided to direct his assets to a cause
that was close to his heart – the Diabetes
Research Institute Foundation.
Kline knew all too well about the toll that
diabetes can take on one’s life. He
suffered with heart disease, which led to
bypass surgery, neuropathy in his feet,
making it difficult to walk, and retinopathy,
causing a loss of vision. Before he lost his
battle with this relentless disease in July
2001, Kline discussed his charitable intentions with the DRI Foundation. He became
a member of the DRI Heritage Society,
which recognizes those who make provisions
for the Institute through their wills, trusts or
other deferred giving vehicles.
“Because of his suffering, he hoped that
he could keep others from having to endure
what he went through,” explained Metcoff.
“He wanted to make an impact by contributing the assets he has accumulated to the
DRI so that a cure could be found.”
Richard H. Kline became a member of the
DRI Heritage Society.
Foundation Donors Recognized
For those who were unable to attend the Cycle of Discovery Donor Appreciation Dinner
last spring, awards were presented to those contributors who have joined the Heritage
Society or donated a major gift during the 2001-2002 fiscal year. Deepest appreciation is
extended to all DRI supporters.
Prior to that, she served in various positions
with the National United Jewish Appeal, and the
Women’s Division at the Springfield, Massachusetts,
Jewish Federation.
“I have had the pleasure of working with Debbie
in both my capacity as executive vice president of the
American Friends of Hebrew University, as well as when
I was the vice president of major gifts for the United
Jewish Appeal. I am well aware of her skills in this area,
and I know she will be a great addition to our DRI family,” said Robert A. Pearlman.
The faculty and staff of the Institute and
Foundation were saddened to learn of the
passing of this truly special person, who
spread good will to others throughout and
beyond his life. The Foundation has subsequently received more than $1,130,000 from
this kind and generous man.
2.
1.
Representative Eleanor Sobel, Florida House of Representatives,
graciously presents a check in the amount of $1,000 for the DRI
to Robert A. Pearlman.
1. Barbara and Shelly Singer present “Exploration,” which is awarded
for a gift of $100,000 or more, to Lisette Ackerberg for a recent contribution she made with husband Norman (not pictured).
2. With husband Kenneth at her side, JoAnn Rifkind accepts a plaque
for becoming a member of the Heritage Society, which acknowledges
individuals who have made a planned gift or have provided for the
DRI in their will.
3. Marvin Meyerson, trustee for the Retirement Research Foundation,
and his wife, Janice, accept “Hypothesis,” which is awarded for a gift
of $50,000 or more.
3
3.
Ramon Poo
Recognized for
Outstanding Contributions
to separate the insulin-producing islet
cells from a donor pancreas, as well
as other equipment for donor bone
marrow processing. Poo has standardized, manufactured and distributed
hundreds of pieces of equipment to
centers worldwide, often for free, or just
recovering some of the material costs,
to help further research toward a cure.
Prior to the development of the
Ricordi Chamber, it wasn’t possible
to separate and maintain enough viable
islet cells to successfully transplant
patients. Because of the success
demonstrated in clinical trials both at
the DRI and other facilities using the
equipment provided by Poo, numerous
islet transplant centers have been set
up around the world.
Ramon Poo, with Dr. Camillo Ricordi by his side, accepts a check for $25,000 from the Health Foundation of South Florida.
Poo was the winner of the 2002 Concern Award for his assistance with developing the Ricordi Chamber and other scientific equipment.
Ramon Poo has recently joined the
ranks of some of South Florida’s most
revered philanthropists. A member
of the DRI Foundation’s board of
directors and, together with his wife
Tina, one of its major contributors,
Poo was presented with the Health
Foundation of South Florida’s 2002
Concern Award, earning him not
only a much-deserved honor, but a
much-welcomed $25,000 grant for the
DRI’s ongoing research. Selected as
the winner among three finalists,
Poo received the award at the
Health Foundation’s annual
luncheon, held November 7 at Florida
International University.
The Concern Award was instituted
by the Health Foundation of South
Florida to recognize an individual who
has made special contributions in the
community. In this particular case,
Poo’s contribution goes well beyond
the confines of South Florida.
For the past 17 years, he has
devoted himself to helping fulfill the
DRI’s mission to find a cure. He and
Tina first contacted the DRI when their
then four-year-old daughter, Cristina,
was diagnosed with Type 1 diabetes.
Together, they became involved with the
Foundation and participated in its many
fundraising events.
In fact, this is not the first time
Poo has received such a distinction.
In 1991, President George Bush
recognized him as one of the Daily
Points of Light stating, “Your efforts on
behalf of those suffering from diabetes
illustrates how each of us can make a
difference in the lives of others, and
how each of us can be a shining
‘Point of Light’ in our community.”
While running Miami-based Altira, Inc.,
a successful plastic bottle manufacturing
company, this family man and father of
three decided to use his engineering talents
to assist the scientists in
developing the critical
equipment they needed
to move research
forward. He has since
spent countless hours
watching scientists work,
understanding the
concepts they envision
and translating their
needs and ideas into
functioning equipment.
Over the years, he has
worked with Dr. Ricordi
to develop the Ricordi
Chamber, the
technology used
throughout the world
4
Ramon and Tina Poo surrounded by their family at the Health Foundation of South Florida’s
award luncheon.
Focused and Passionate,
Jed Ringel is Just Getting Started
For Jed Ringel, life is not a spectator
sport. A man committed to taking action,
he has spent the past few decades coming
off the sidelines for a number of issues
and causes.
During his early college years he had
a keen interest in sculpting, and went on
to pursue the study of art. An enterprising
young man, he supported himself by
driving a taxicab around New York City.
Though he struggled to maintain his own
sculpture studio in Brooklyn, he still
found time to teach his trade at various
settlement houses on Henry Street and
other places.
Soon after, he came to realize another
calling and enrolled in law school,
graduating magna cum laude from New
York University School of Law. While
there, he was awarded a Civil Liberties
Fellowship, and spent some time working
at the American Civil Liberties Union.
He later used his legal background to
perform several years of pro bono service
for Haitian refugees.
After spending almost a decade as a
litigator with Stroock & Stroock & Lavan,
he built and ran a successful legal auditing
firm, Law Auditing Services (now called
Allegient Systems), which he sold two years
ago. Today, however, Ringel is anything but
retired. He devotes much of his time to
various charities, raising funds, serving on
committees, and even designing and maintaining gardens around homeless shelters.
To say Ringel is driven by a desire to
“right the wrong” is an understatement.
So when one of his twin daughters, Jamie,
15, was diagnosed with Type 1 diabetes
three years ago, it came as no surprise
that he would passionately pursue her
cause, as well.
The Ringels learned of Jamie’s diagnosis
when she began experiencing the typical
symptoms that accompany the onset of
diabetes. After suffering with acute
headaches and constant urination and
thirst, she was rushed to the hospital and
spent three days there while the doctors
normalized her blood sugar levels.
“It was difficult for Jamie to comprehend
the scope of this disease, and exactly what
having diabetes meant. After she left the
hospital, she thought that it was over,” he
recalls. “She had no idea that the management of the disease would become her life’s
ritual.” At the time, he didn’t realize that
finding a cure would also become his.
Gary Kleiman, DRI executive director of medical development, with
Jed Ringel and his wife, Cindy Epstein.
Within a few months, Ringel began
publishing a newsletter for the families and
patients of the medical facility where Jamie
received her care, and formed a parent’s
support group. He also educated himself
about diabetes research, and came to
understand that a cure for the disease
touched on many areas of basic science.
Together with his wife, Cindy Epstein,
he launched a local fundraising effort in
Connecticut with the goal of supporting
research toward a cure. “What we were
trying to find was a facility that would
pull all of these disciplines together to
concentrate on curing this disease, and all
that would be needed was the funding,”
said Ringel, who soon found himself on an
odyssey to find such an institution.
Wanting to know more, he attended
the DRI Foundation’s New York Research
Update two years ago. “I didn’t know what
the DRI was, but I went and listened to
Dr. Ricordi, Dr. Kenyon and Dr. Edlund,
and I walked away with a pretty comfortable
understanding about what areas of science
5
were the remaining issues,” he remembers, and was eager to learn more about
the DRI’s work.
Over the next year, he visited a
number of research facilities, eventually
coming to the DRI in March of last
year. “My visit there really opened my
eyes about the world of diabetes
research, and it left a number of
impressions on me, most significantly
that 1) a proper research facility in the
area of diabetes needs to combine
basic, pre-clinical and clinical research,
all of which is at the DRI; 2) the pace
of research is dependent upon a
number of factors, including a willingness to be open with other researchers;
3) in the two critical areas remaining
in islet cell transplantation – supply
and tolerance – many, many of these
avenues are being pursued at the DRI;
and 4) in the history of this disease,
there had been virtually no research
for 50 years since the discovery of
insulin in 1929. Yet, many of the
powers that be in the diabetes world
had viewed islet transplantation
skeptically, and therefore, the
significant portion of funds raised
for diabetes were not going for
cure-related research.”
Armed with a solid base of
information, Ringel, who recently made
a $100,000 gift, has augmented his
fundraising efforts in Fairfield County,
Connecticut, on behalf of the DRI,
reaching out to more and more families
who he feels share his passion for
curing this disease. “I want people to
know that the notion of a cure is not a
‘pipe dream,’” he says. “I want to share
what I’ve learned with them, and in
turn, have them join me in supporting
the DRI’s mission. So far, the response
has been positive. Everyone has been
grateful to learn more, and I’m just
getting started.”
Young of Age,
Young at Heart,
Silver Ridge Turkey Trot
Taking a break from their weekend ritual of
sports activities, movies and arcade games,
three enterprising elementary students, Jesse
Greene, 10, Daniel Alon, 9, and Garrett
Abrams, 9, of Jericho, New York, put their
heads together and worked out a plan to raise
money to help find a cure for Type 1 diabetes.
Armed with a photo of their close friend,
Bryan Joachim, who was diagnosed with the
disease at the age of two, and with compassion in their hearts, the boys set out to reach
their objective. Tirelessly walking the streets of
their neighborhoods, knocking on each and
every door, they told of their mission to raise
money to help their friend and countless others affected by the disease.
“I had no idea that so many kids had diabetes just like me,” exclaimed Amber Roach,
6, who joined more than 120 other guests
in becoming scientists for a day at What’s Up
Doc?, an interactive tour of the DRI for
children with diabetes and their families.
Held Saturday, November 9th, during National
Diabetes Awareness Month, the free event
featured hands-on demonstrations by the
scientists who are actively searching for a cure,
plus an inspirational speech by Olympic gold
medalist Gary Hall, Jr., hailed the fastest
swimmer in the world.
“When I was diagnosed with diabetes in
1999, two doctors told me that my swimming
career was over,” Hall informed the intent
crowd. “But, this is what life is all about –
challenges and working to overcome those
challenges. Needless to say, I found a new
doctor, and one year later, I went on to
compete in the 2000 Olympics.”
(l-r) Silver Ridge Elementary Principal Marion Gundling, physical education teacher Becky Griffin, and second grade team leader Vickie
Mooney with third graders Gabriela Gallo and Eddie Calderin, kindergartener Juan Carlo Gallo and fourth grader Morgan Mooney.
“One summer day I decided I was going to
collect money for charity. I thought about
which charity to pick. Then I thought about my
good friend Bryan Joachim, who has diabetes,” wrote Jesse. “I thought it would be
great if doctors could find a cure so that
Bryan could be healthy like everyone else.”
Thankful for their own blessings, more than 1,000 students, parents and teachers of
Silver Ridge Elementary School in Davie, Florida, wanted to give something back to the
community this past Thanksgiving holiday. They decided to turn their annual Turkey
Trot run/walk, held on Wednesday, November 27, into an event that provides hope to
millions of people affected by diabetes.
Jesse concluded, “From this experience
we learned no matter how young you are,
if you care, you can make a difference in
this world.”
The mile-long Turkey Trot began 15 years ago and was conceived by the school’s
physical education teacher Becky Griffin as a fun way to promote physical fitness.
This year, they chose to conduct the walk with a cause in mind, raising more than $5,600
for the DRI.
“Diabetes affects so many families we know. So, choosing the Diabetes
Research Institute as the first and only beneficiary of this event was received with
great enthusiasm,” said Vicki Mooney, first grade teacher and walk coordinator.
Myriad drawings decorated the hallways of the school prior to the event, expressing
the students’ eagerness to assist those affected by this disease. A variety of sentiments
scribbled on posters communicated the children’s desire to do their part in raising
much-needed funds to help find a cure. Their enthusiasm was also displayed proudly
on the school’s marquis for all to see.
(l-r) Daniel Alon, Jesse Greene and Garrett Abrams went door
to door to raise money for the DRI.
What’s Up Doc?
Takes on a New Tradition
Wise Beyond Years
With each house visited, the boys
expressed themselves with confidence and
kindness, showing Bryan’s picture to each
homeowner, who, in turn, rewarded them with
generous donations. They were astounded
with the results of their endeavor. They raised
$4,200, by far surpassing their original goal.
In a letter to the DRI, Jesse, who spearheaded
the project and enlisted the help of friends
Daniel and Garrett, explained why they set out
to help the DRI.
Empowering Families at
One by one, teachers led parents and students, grades kindergarten through fifth,
to the starting line, where they waved signs bearing the names of their classes. Under
the direction of Principal Marion Gundling, the higher grades started the walk with the
lower grades not far behind. At the finish line, the children cheered victoriously, giving
numbing high-fives as they headed to the school’s pavilion for their traditional
Thanksgiving lunch.
6
“Bugs Bunny” poses with (l-r) Robert A. Pearlman and DRI faculty: Dr. Camillo Ricordi, Dr. Alberto Pugliese, Dr. Elizabeth Fenjves, and Dr.
Ricardo Pastori.
The program concluded with a healthy lunch and closing
remarks by Gary Kleiman, who was the recipient of the Institute’s
most recent islet cell transplant.
Following breakfast and opening remarks, families were split into
four guided tour groups as they began making the rounds from lab
to lab. One stop, titled Genetic Park, was led by Dr. Alberto Pugliese
and his 13-year-old “lab assistant,” Jaimie Rotman. The seventh
grader, who was diagnosed with diabetes three years ago, was
fulfilling a mitzvah project, or a
“good deed,” for her upcoming bat
mitzvah. Her time spent at the
Institute taught her all about islet
cell transplantation, a procedure
aimed at reversing diabetes.
“How are you going to find
enough islet cells to cure all people
living with diabetes?” Rotman
asked during her initial training
session. She learned that the DRI
is a pioneer in islet cell transplantation and much of the research
currently underway is aimed at
answering her exact question.
On the day of the
event, Rotman
was able to relay
this information
to the other kids,
who just like her
discovered why
the Diabetes
Research Institute
is the best hope
for a cure.
“The dream of the families that started this place is for you.
Eight days ago I got to be a part of this dream. I haven’t needed
any insulin for the first time in almost 43 years,” he stated as the
crowd applauded, joining in the thrill of his good fortune.
He finished with a few encouraging words, “There will be good
things in the future.”
1.
3.
1) Sporting an Olympic gold medal, five-year-old Austin Burns, who was
diagnosed early last year, gets pumped up with Gary Hall, Jr.
2) A young scientist for a day examines a penny under a microscope.
3) “Lab assistant” Jaimie Rotman, seated, instructs some participants in
the Gene Therapy Lab.
2.
7
Preview Party Offers a Hint of Things to Come
Following Singer’s poignant speech, a
blanket of silence enveloped the audience,
many of whom knew Debbie personally,
many of whom have children of their own
suffering with diabetes. Her words of a
parent’s love struck a solemn chord in all
that were present. The next speaker offered
words of hope.
Continued from cover story
“After living with diabetes for 47 years, I
am happy to report that I am now insulin
1.
2.
Embodied by the spirit of giving, the
29th Annual Preview Party recently kicked
off the charitable season of Love and
Hope. The elegant soiree, held at the
distinguished Diplomat Country Club, is
exactly as its name suggests, a preview of
festivities to come – namely the Love and
Hope Ball. Underscoring the evening’s
benevolent mood, guests contributed more
than $607,000 for the DRI.
Chairmen of the 29th Annual Ball.
Additionally, unlike any year before it, the
Ball will have two honorees: Love Honorees
Luis and Norma Quintero and Hope
Honorees Helene Westreich and Seymour
Rosenblatt. Perennial Silver Star Florence
Frank, a Distinguished Humanitarian in the
Foundation’s Cycle of Discovery program,
was graciously thanked for her longtime
3.
independent,” stated Ken Bernstein, lovingly
referred to as “Number 13,” for becoming
the 13th islet cell transplant recipient as
part of the ongoing clinical trials at the DRI.
“I looked up the word ‘hero’ in the
dictionary, but I’ve come up with my
own definition. To me, you are all heroes,
because you have put your time, energy
and money into curing this disease.”
4.
5.
“When my family helped start the DRI,
my daughter, Debbie was just two years
old, and I truly believed that if I put my
life into it, she would be spared,” said
Barbara Singer, director of administration
for the DRI Foundation. “After 31 years
with diabetes – and struggling for more
than 10 years with every complication
of this devastating disease – our beloved
involvement in the organization and her
continued generosity.
6.
7.
daughter lost the battle, and our hearts
were broken.”
Continuing the program, Life Chairman
Sonja Zuckerman and Executive Chairman
Sandra Levy thanked Isabel May for
underwriting the Preview Party. Deepest
gratitude was also extended to sponsor
Cartier, which showcased several glamorous
pieces, donned by their Signature Panther
Models, during the cocktail reception.
Noleen Stewart, longtime friend of
International Chairmen Linda and Barry
Gibb, entertained guests before dinner with
her beautiful singing voice.
An announcement was made, declaring
Barry and Carole Kaye as the Honorary
8
New York
Research Update…
Those who also made a significant gift
that evening were Barry and Carole Kaye,
Helene Westreich, Sue and Doug Gallagher,
Sherman Simon, Isabel May, Luis and
Norma Quintero, Florence Frank, Roberta
and Harvey Chaplin, Linda and Barry Gibb,
Penny and Robert A. Pearlman, Kathy
Chesler and Steve Posner, Louis Nieweg,
Mark Rubin, Barbara and Sam Herzberg,
Barbara and Sheldon Singer, Carol and
Morton Blumberg, Cindy Carr, Anne Gache,
Fran and Mel Harris, Sylvia Kwasha, Ruth
Rosenberg, Jacci and Floyd Seskin, and
Sandra Smith.
1. Isabel May, who underwrote the Preview Party, with Susan Pullin,
manager of Cartier/Bal Harbour, with the Signature Panther Models.
2. Life Chairman Sonja Zuckerman with Honorary Chairmen Carole
and Barry Kaye.
3. Perennial Silver Star Florence Frank with Hope Honorees Helene
Westreich and Seymour Rosenblatt.
4. Love Honorees Luis and Norma Quintero
5. International Chairman Linda Gibb with her daughter-in-law,
Therese Gibb.
Dr. Brunicardi went on to present an
overview of his work in the molecular
engineering of islet cells and the study
of cell-to-cell communication within the
pancreas in order to determine which
signals are responsible for triggering
the production of insulin. Using a mouse
model, he and his team were able to
identify the particular cell within an
islet (delta cell) that is responsible for
turning “on” and “off” the production
of insulin in response to changes in blood
sugar levels. Further areas of study will
use molecular engineering techniques
in an attempt to create better islets
for transplantation.
After an introduction that roused a
standing ovation, Dr. Camillo Ricordi,
Stacy Joy Goodman professor of surgery
and medicine and scientific director of
the DRI, discussed islet transplantation
and the future. He recounted the story of
when, as a young researcher in 1986, he
asked permission to retrieve a discarded
pancreas to test his “crazy” idea for islet
separation. After successfully removing
the insulin-producing cells, it took but a
mere two weeks before Dr. Ricordi’s
method of islet isolation would replace
all other procedures.
Dr. Ricordi presented some encouraging
statistics on the success rate of islet
transplantation, noting that a high
percentage of transplant patients remain
insulin independent up to two years
post-transplant. He also reported that
the DRI has continued to improve upon
current transplant protocols with new
preservation agents that have now become
the standard for islet transplantation today.
The challenges going forward, he said,
remain the same as they were five years
ago – to determine safer
methods to induce transplant tolerance
and to develop an unlimited supply of
islets for transplantation.
Addressing the latter issue, Juan
Dominguez-Bendala, Ph.D., a member
of the DRI’s Pancreatic Stem Cell
Development Laboratory, discussed the
work underway in the isolation and study
of pancreatic stem cells. Dr. Bendala
reported that since it has been difficult
to determine just how to make islet cells
regenerate, scientists have turned their
attention to stem cells, which are the
unique cells that have the potential to
become any type of tissue in the body.
By investigating various molecular signals,
scientists are aiming to direct the growth
of stem cells into islets. Another avenue
of work involves the use of
pancreatic progenitors, which are the
cells that have already been committed
to developing into either pancreatic
endocrine or exocrine tissue. By understanding the signals that turn these early
cells into insulin-producing cells,
researchers hope to guide them down the
path to become islets.
Dr. Massimo Trucco, the Hillman
professor of pediatric immunology, and
head of the Division of Immunogenetics
at the University of Pittsburgh,
discussed islet cell regeneration within
the pancreas. Since Type 1 diabetes is
an autoimmune condition, the patient’s
own immune system attacks the insulinproducing beta cells. It has been shown
that these particular pancreactic cells
have regenerative properties. Dr. Trucco
and his team have demonstrated, in a
mouse model, that once the autoimmune
process is halted, it is possible to allow
the regeneration of these cells in the
pancreas and restore normal blood
sugar levels. Dr. Trucco shared his
findings from this study and how this
promising work may be valid for use in
patients with diabetes.
Dr. Norma Sue Kenyon, associate
director of research and program
development, discussed some of the new
therapies that are being tested at the
pre-clinical level with the ultimate goal of
eliminating the need for immunosuppression in islet transplant patients. Currently,
these patients must take anti-rejection
drugs for life to maintain the functionality of
their transplants. Avenues of research
now being pursued focus on identifying
some of the key signaling pathways that
cause rejection, and blocking these signals before the process begins. The safer
approaches toward achieving transplant
tolerance that are now under investigation at the DRI include using high doses
of donor bone marrow to achieve
macrochimerism as well as novel
immuneintervention strategies.
Topping off a morning of optimistic
research reports, attendees were treated
to an inspiring talk by Ken Bernstein,
who lived with diabetes for 47 years
before receiving his islet transplant at the
DRI in the spring of last year. Bernstein
recounted the challenges of life with the
disease, which was all too familiar to
those in the room, and how he first
learned about islet transplantation and
Dr. Ricordi back in 1987.
6. Life Trustee Eleanor Kosow with Sherman Simon, who will be
underwriting the cocktail reception at the upcoming gala.
7. Executive Chairmen Sandra and Sid Levy
9
“Little did I know that 15 years later
the same Camillo Ricordi would be
holding my hand as he transplanted me
with islet cells that would produce insulin
in my liver,” he said.
After receiving his first transplant in
March, Bernstein was transplanted again
at the end of May. “Since that wonderful
day 148 days ago, after 17,333 days
on insulin and over 60,000 insulin
injections, I have not had the need to
squirt one more drop of insulin into my
unyielding body, and my blood sugars
have been spectacular. I am free at last
and miracles do happen.”
Also during lunch, a surprise guest was
honored with a plaque of appreciation
for accomplishing an incredible feat.
Jim McCord of Kentucky, who has a
daughter with diabetes, completed a
cross-country run from San Diego to
Washington, D.C., to raise awareness
about the need for increased government
funding of diabetes research.
Other speakers who participated in
the afternoon breakout sessions were
Dr. Holly Schachner of the Naomi
Berrie Diabetes Center, and Stephanie
Schwartz, RN, MPH, CDE, of Children
With Diabetes.
1.
2.
3.
1. Robert A. Pearlman thanks N.Y. Research Update Co-Chairs Marc
and Esther Goodman, and Dr. Denise and Thomas Stern.
2. Ken Bernstein together with the other DRI islet transplant patients
who attended the conference, Rita Hart (left) and Rachel Harris.
3. Dr. Camillo Ricordi with Rowland Schaefer, one of the
Foundation’s largest supporters, and Donna Shalala, president of
the University of Miami, at the dinner held the evening before the
research update.
Under the Microscope
DRI
With Ricardo Pastori, Ph.D.
Around the DRI
What is Signal Transduction?
New Frontiers of Study
Gene Therapy Moves Forward
at the DRI
In the last 10 years, significant advances have
been made in understanding how cells communicate with each other. Cell-to-cell and environmentto-cell communication has become increasingly
important to understanding both the cause and
development of many human diseases. A key element of this communication network is the transmission of signals into the cell and eventually to its
nucleus, or command center. This cascading relay
of information is called signal transduction, and
lies at the heart of how our bodies function and
maintain good health.
Dr. Per-Olof Berggren,
from the renowned
Karolinska Institute in
Sweden, is the DRI’s
newest faculty member
and the director of the
new cell biology and
signal transduction
efforts. Dr. Bergrren is
known for his important
contributions in unraveling the insulin signaling
system in mouse beta cells, the specific cells within
islets responsible for insulin secretion. During the
last months, human islets isolated at the DRI have
been shipped to Dr. Berggren’s lab in Stockholm
to determine, in part, if the structural differences
between mouse and human islets also have physiological consequences. This first series of collaborative experiments will help define parameters which
can be used in clinical laboratories for islet quality
control and improved transplantation outcomes.
Elizabeth Fenjves,
Ph.D, has just been
awarded a grant from
the American Diabetes
Association to investigate if the gene therapybased modifications she
has been working on
can be used to enhance
islet survivability and further improve the results of islet transplantation.
How exactly is it that molecular messages
from outside a cell, for example, can produce an
intra-cellular response within the cells? We know
that glucose is a trigger for insulin release, but we
know little about the mechanism. What role does
abnormal “signal transduction pathways” play
in the development of diabetes, and how can
scientists harness these intricate pathways to
prevent disease?
Scientists already know that abnormal signaling
plays a role in the onset of diabetes and other
metabolic disorders, but much of that information
comes from bench work in the lab or from studying small animal models as opposed to human
cells and living tissues. But there are differences
in the structure of mouse islet cells as opposed to
human islets that could well represent significantly
different routes of communication between cells.
Thus studying signal transduction as it exists in
human islets, both in vitro and in vivo, is an
important basic step in understanding the onset
and evolution of complex diseases such as
diabetes. Understanding which mechanisms
outside the cell can produce responses within the
cell, and how they do so, will allow scientists to be
able to modify or block the cascade of events that
lead to disease through the use of new drugs or
novel interventions. This cell biology based
approach, is in fact, being pursued by scientists
across many research disciplines, and is at the
core of the DRI’s newest research initiative.
In addition, a new grant has been submitted
by the DRI to study the role that calcium may play
in controlling both the secretion of insulin and
triggered cell death in human islets, where very
little is known. The experiments will require stateof-the art techniques in signal transduction pathway
studies and the genetic engineering of islets with
fluorescent proteins so that changes in signal
transduction pathways can be visualized easily (the
cells will “glow” when modified and their images
captured readily).
The addition of a signal transduction laboratory
under an internationally-recognized expert such as
Dr. Berggren maintains the DRI at the forefront of
biomedical research. Combining this new initiative
with existing DRI expertise in human cellular isolation and clinical islet trials offers an opportunity to
establish islet guidelines that exists nowhere else.
The measurement of calcium signaling, glucose
metabolism, insulin secretion, and cell death in
human beta cells, supported by state-of the-art
methods of imaging and electrophysiology, will help
shed light on factors which affect islet quality, at
both the pre- and post-transplantation stages. The
DRI will again play a leading role in translating
promising research findings from basic, small
animal models to more relevant human cellular
systems with greater patient applicability.
10
Islet transplantation has made important strides
in the last five years and is now the treatment of
hope for Type 1 diabetes, but the premature death
of islet cells once they’ve been transplanted
remains a major obstacle that needs to be
overcome. Ensuring that virtually all of the
transplanted islets survive will eliminate the current
need for multiple donors to reverse diabetes in
each patient. This is especially important since
there is a large discrepancy between the number
of people who could benefit from the procedure
and the number of available organs for transplant.
Every islet counts.
Until now, gene-based strategies have been
hampered by the lack of appropriate “vectors”,
or carriers that serve to insert genetic material into
islets. In the past two years, Dr. Fenjves’ laboratory
has been able to successfully introduce genes into
islets in a safe and efficient manner using a new
generation of a vector called FIV. Using this delivery
system, Fenjves and her team will modify islets
prior to transplantation by introducing genes that
specifically block the destructive pathways
encountered by islets once they’re transplanted.
The overall goal will be to improve islet survival
and thus reduce the number of cells needed per
transplant. Ultimately, this work will contribute to
new therapeutic approaches that may improve the
success rate of clinical islet transplants, and the
quality of life for an increasing number of Type 1
diabetic patients.
A section of beta cells transduced with a Protein
Transduction Domain, or PTD, from the TAT protein one of the proteins believed to block cell death.
The fluorescence (bright spots) indicates the
presence of the PTD inside the cells.
Over the years, Ricardo Pastori, Ph.D., director of the DRI’s molecular
biology laboratory and research associate professor of medicine at the
University of Miami School of Medicine, has applied his expertise in molecular
biology to the development of key technologies that assist the Institute’s efforts to cure diabetes through islet
transplantation. One of the remaining challenges is to obtain a sufficient amount of these insulin-producing
cells, which comprise only one to two percent of the total pancreas. Dr. Pastori’s work aims to
eliminate this challenge.
Dr. Pastori and his team have recently embarked on a new initiative to increase the number of healthy
yield and viability of islets obtained from a donor pancreas. During the isolation process, the clusters of
insulin-producing cells known as islets are put through a series of mechanical, chemical and organic stresses
that can trigger a natural process known as apoptosis or “cell death.” Researchers believe that this is one of
the major factors that leads to islet cell loss after a single donor transplant, and it’s the reason a second or
third infusion is needed for the recipient to become insulin-independent. By minimizing islet loss caused by
the isolation process, the increased number of islets should be sufficient to reverse diabetes with a single
infusion and, perhaps provide enough islets for more than one donor. The results of this work were
published in the journal, Diabetes.
Q. What is your area of research at the DRI?
A. I’m working on the generation and application of molecular strategies to achieve both improvement of
pancreatic islet viability and the ability to create or “induce” a state of tolerance to transplanted islet cells.
Q. How do you aim to increase the viability of islet cells?
A. The concept of cytoprotection implies that islet cells are somewhat treated or modified to be resistant to
diverse events that will assure they maintain their effectiveness. These events occur during isolation in culture
and subsequently in transplantation.
For example, the process of isolating the islets, which are embedded in the pancreas, triggers a
biochemical response that will induce cell death in a high proportion of islets. Theoretically, it is possible
to interfere with this cell death signal by introducing peptides or proteins that will block this biochemical
pathway into the islets.
Q. How are these protective proteins delivered to the islet cell in order to prevent cell death?
A. With a few rare exceptions, nucleic acids and proteins are unable to cross cell membranes, thus
impeding successful therapies through their direct use. It is possible to deliver proteins/peptides to cells
by fusing them to Protein Transduction Domains (PTD). PTDs are small peptides that have the capability to
freely cross cell membranes. We are investigating the possibility of delivering different cytoprotective
PTD-proteins to improve islet transplantation at different stages. Protective-fused proteins could be delivered
to the pancreas prior to islet isolation to block or inhibit cell death induced by the process of islet purification.
Protein transduction also can be used to improve viability during islet culturing, a critical step that affects
islet functionality. This approach could also be used during the organ retrieval process to prevent cell or
tissue damage.
Q. What experiences inspired you to pursue a career in science?
A. In my case, affinity rather than a set of experiences was the determinant in choosing a scientific career. As
with any other job, I thoroughly enjoy when a hypothesis proves to be correct and things are done with results
as expected.
Q. What led you to work at the DRI?
A. I received my Ph.D. in chemistry from the University of Buenos Aires, Argentina. Then, I went on
to pursue further research at the University of Rochester in New York and at the Chemistry Institute of the
University of Saõ Paulo, Brazil. In 1992, Dr. Mintz, former director of the DRI and scientific director emeritus,
recruited me.
11
New York’s Fall Into Fashion
Alabama Makes Strides For a Cure
Reaches New Heights
event co-chairperson, remarked, “It’s
always fun to see the new fall fashions on
display at this luncheon, and we have a
good time with friends while raising funds
for a worthy cause.”
With sneakers on and laces tied tightly, more
than 500 people turned out at Hank Aaron
Stadium for the First Annual Dollars Against
Diabetes (D.A.D.) Walkathon, held in Mobile on
November 9th. Participants made great strides for
the DRI as they took off on a 5K walk, side-by-side
with San Diego Padres pitcher Jake Peavey, who
led the charge of families, sponsors and volunteers
from the front of the stadium to home plate.
Raising more than $60,000 for the DRI,
the D.A.D. Walkathon was the first scheduled
fundraising event for the newly opened Foundation
office, headed by Alabama Regional Director
Madeline Culpepper. Participants enjoyed a variety
of activities, such as face painting and “tattoos,”
plus all had the opportunity to win wonderful
prizes. Attendees who raised $1,500 or more were
placed in a drawing for a 27” color TV; those who
raised $200 or more received a DRIF T-shirt; and
walkers who raise $100 or more received a
colorful collectible Snoopy lapel pin.
Apropos of the ballpark location, attendees
replenished with delicious hot dogs provided by
title sponsor Mobile Gas. Corporate Recruitment
Chairman John Davis, president & CEO of Mobile
Gas, was proud to announce that his corporate
team and Springhill Medical Center were the top
winners. Winning family teams included Chad’s
Champions and the Gilley Family Team. Williams’
Walkers, headed by captain Florence Williams, was
the top new family team. Monroe County Hospital
won the design-your-own T-shirt contest with their
spirited submission: “Somewhere over the rainbow, there’s a cure for diabetes.”
1.
2.
The heartwarming “Hope & Cure” pin is elegantly
encrusted with diamonds, representing the donor’s
involvement with the DRI. With a contribution of $1,000
the donor receives a pin adorned with a center of diamonds
(top). For another $1,000 donation, the top ribbon of the
pin becomes decorated with diamonds (middle). The pin
is completely covered in diamonds for a total pledge of
$6,000 (bottom).
3.
Additional sponsors included Buffalo Rock
Pepsi Cola, Hank Aaron Stadium, Pilot
Catastrophe Services, Inc., Providence Hospital
and Colonial Bank.
Furthermore, various local schools raised funds
for the Institute, including Dodge Elementary,
Robert E. Lee Elementary, McGill Toolen High, Saint
Ignatius, Saint Mary’s, Nan Gray Davis Elementary,
and Baker High.
4.
Picture this – you walk into a posh
restaurant for a fashionable luncheon.
You’re seated next to the most elegant and
stylish women you have come across in
quite some time. You are offered an entrée
selection so tempting that you forget about
your diet. The models start to saunter down
the runway. But wait! You recognize them.
Aren’t those fashionably clad ladies the
cast members from the hit Broadway show,
Thoroughly Modern Millie? “Where am I,
anyway,” you ask. “Paris, Milan?”
While hobnobbing with the Honorary
Chairs Roxane Barlow and Amy Higgins,
dancers in the cast of the show, the crowd
delighted in a sweepstakes drawing of nearly
100 fabulous prizes. Prior to the event,
sponsor Saks Fifth Avenue/Garden City
drew droves of people to the store entrance
with sweepstakes ticket sales. Fabulous
grand prizes included a Michael Kors fur
scarf and a Judith Ripka Necklace, both
valued at $1,500, plus a weekend at
Great Neck Inn, Leslie Green earrings, and
a Mark of Excellence dinner party for six.
Additional items included a trip to California
and lunch with the cast of Everybody Loves
Raymond, tickets to Broadway shows, and a
day of beauty at Saks’ Red Door, among
others. The ladies also got a glimpse of the
DRI’s new “Hope & Cure” pin, which made
its debut at the luncheon.
Priscilla Kleinberg and her two daughters,
Susan Kleinberg Bushell and Addy
Kleinberg Fritzhand, who was diagnosed
with Type 1 diabetes as a small child, were
this year’s event honorees and sponsors. The
Kleinberg women continue to be active volunteers and support a number of the DRI
Foundation’s events throughout the year.
1.
2.
3.
1) Chairpersons Ileen Joachim (center) and Jody Greenbaum
(left) join Bobbie Krieger of Saks Fifth Avenue at the podium.
2) Ileen and Jody flank Honorary Chairpersons Amy Higgins
and Roxane Barlow, with Long Island’s Assistant Director
Shelley Kaplan (right).
3) The Kleinberg family, luncheon sponsor, gather for a group photo.
4) The 2002 Fall into Fashion committee.
Sincere gratitude is extended to the entire
committee for their tireless efforts and continued support in the search for a cure.
But, no, you’re not. You’re in New York
at the Annual Fall into Fashion Luncheon,
held on November 7th at Carlyle on the
Green in Bethpage State Park. The event,
showcasing only the most chic apparel
from Saks Fifth Avenue/Garden City, welcomed more than 500 guests and raised
more than $188,000, a record amount
since the luncheon’s inception.
1) Chris Dyas, chairman of the Alabama board of directors, with
his son Adam (right) meet John Davis (left) at the finish line.
2) Padres pitcher Jake Peavey (left) lines up at the starting line next
to his good friend and stadium operations assistant Wade Vadakin
(right), who has diabetes.
3) Fourth and fifth graders from Robert E. Lee Elementary raised
more than $700.
4) Megan Robertson and Dane Bishop, who both have diabetes,
helped to raise $520 at Nan Gray Davis Elementary School.
5) Dodge Elementary School held their own walkathon for the DRI,
raising more than $4,000.
Ileen Joachim, a committed and
dedicated supporter of the DRI and
5.
12
4.
13
Empire Ball
DRI Golf Classic Swings Another Success
Raises a Record $1 Million
The prestigious Trump International Golf Club hosted more than
100 golfers and sports celebrities on January 6th for the Third Annual
DRI Golf Classic. Senior PGA member and golf legend Raymond Floyd
again served as Honorary Chairman for the event. According to Cochairmen Michael Singer and Ronald Kochman, the tournament raised
$200,000 for the DRI.
1.
2.
4
3.
5.
6.
1. James Migliore accepts his award from last year’s Honoree John Santora, Cushman & Wakefield. 2. Michael Perrette with last year’s Humanitarian Award recipient Jay Koven, Ambassador Construction.
3. Dr. Camillo Ricordi and Robert A. Pearlman enjoy the success of the evening. 4. Standing (l-r): Carole Campolo; Mary Ann Alfano, Creative Events; Rene Checchia, Kaufman Organ. Seated (l-r): Elsie Jones, Pat McGillen,
ABM. 5. Mr. and Mrs. Paul Incorvaia with Mr. and Mrs. Charles Rizzo. 6. Peter DiCapua and Migliore with Dinner Co-chair Frank Freda, Cushman & Wakefield.
At the Fourth Annual Empire Ball, where New
York’s real estate industry unites, the evening’s proceeds surpassed the one million-dollar mark. It is the
first event outside of Florida to achieve this distinction. The black-tie affair, held at the Grand Hyatt
Hotel in early December, paid tribute to Honoree
James Migliore, chief operating officer of The Durst
Organization, and Michael Perrette, vice president of
Prudential Financial, who received the Camillo
Ricordi Humanitarian Award.
Migliore, a native New Yorker and 30-year veteran
of commercial real estate and engineering, oversees
day-to-day operations of one of the city’s oldest and
largest owner/developer firms, with a portfolio of
more than 7.5 million square feet of office retail
space. The Durst Organization is widely recognized
as a world leader in the development of technologically advanced and environmentally responsible
commercial property. Migliore, who is extensively
involved in civic and social initiatives, sits on the
board of directors of the Real Estate Board of New
York’s management division and the Realty Advisory
Board on Labor Relations, and is a member of the
President’s Council of the Real Estate Roundtable.
Perrette is the recipient of this year’s Camillo
Ricordi Humanitarian Award, named after the
DRI’s scientific director. Formerly of Chase
Manhattan Bank, Perrette currently oversees
operations, engineering functions, and alterations to
the company’s workplace. He has been involved,
both personally and professionally, in a host of
charitable organizations.
Attracting 1,300 guests, the evening was hosted
by sportscaster Sal Marciano and included a special
guest presentation by comedian Ray Romano
via videotape.
“Tonight, you are honoring two men who had the
opportunity to witness, first hand, a scientific miracle
that you helped make happen,” stated Romano, star
of the hit television show, Everybody Loves
Raymond. “James Migliore and Michael Perrette
made a trip to Miami and arrived on a day when DRI
scientists changed the life of a man who suffered
with diabetes for 42 years. This man received an
islet cell transplant, and for the first time in four
decades, he no longer needs insulin shots.”
Romano’s inspirational words spread applause
amongst the crowd, which included Empire Ball
Chairman Peter L. DiCapua, Committees Chair John
C. Santora, who is also a past honoree, Committee
Co-chair Charles Rizzo, and Advertising and Public
Relations Chairman Gerald D. Schein, among others.
“Previously, only owners attended the event,” said
DiCapua of ATCO Properties & Management, Inc.
“It has now become an integrated event,
encompassing many parts of the industry, including
owners, brokers, management companies, corporate
owners, facility people, consultants and contractors.”
Rizzo of Charles Rizzo & Associates added,
“This year’s event was the best we’ve had.
Everything ran smoothly and efficiently, and
everyone had the opportunity to interact with
people from the whole industry.”
Guests played side-by-side with famous sports figures, such as NBA
Hall of Famers Dave DeBusschere, Richie Guerin, and John Havlicek;
NFL and three-time Pro Bowl player Leonard Marshall; Olympic
swimmer and gold-medalist Gary Hall, Jr.; and LPGA Tour member
Michelle McGann. Additionally, Grand Funk Railroad’s Don Brewer
joined the sports celebrities and other enthusiastic golfers on the green.
1.
Following the tournament, guests delighted in an evening at the
renowned Mar-a-Lago Club, where they enjoyed cocktails, sumptuous
gourmet fare and musical entertainment by Rachael Baylee and Frank
Licari. During dinner, CBS sportscaster Pat Murphy, acting as auctioneer, led an exciting bidding war for a bevy of exclusive items, including
a week-long South African Safari package, provided by Zulu Nyala
Vacations, and a Locman lady’s watch with beveled diamonds, provided
by Mayors Premier Jewelers. Other items included signed basketballs
from the participating former NBA players, who were personally on
hand to autograph them, plus music memorabilia donated by Brewer,
who spontaneously treated the crowd to an a cappella rendition of his
group’s classic hit, “Some Kind of Wonderful.”
2.
At the dinner reception, the top winning foursome, made up of Barry
Brodsky, Doug Fields, Sergio Rok and Steve Sager, was presented with
awards. They were closely followed by three other teams: Chris
Anderson, Doug Gallagher, Andrew Gallagher and Alexander Vara, who
played with Michelle McGann; Gary Cohn, Andrew Brock, Ron
Kochman and Andy Seltzer; and Steve Hayworth, Livan Hernandez,
Javier Holtz and Brad Hopkins.
Many organizations and individuals lent their support to this successful event. Serving as the event’s Title Sponsor was the Building
and Construction Trades Department of the AFL-CIO and its affiliates.
Also lending generous support as a Gold Sponsor was Union Labor
Life Insurance Company (ULLICO). Participating as the Sterling
Sponsors were The Estate of Mabel B. Conklin, Mercedes-Benz of
Palm Beach and Stanford Financial Group; and serving as Bronze
Sponsors were Comiter & Singer, LLC, Gibraltar Bank, International
Association of Heat and Frost Insulators and Asbestos Workers, J. Ira
and Nicki Harris, Javier and Andria Holtz, Kochman and Braun, PLC,
Mayors Premier Jewelers, Subway, Union Planters Bank, and
Wilmington Trust.
1. Celebrity golfers: Gary Hall, Jr., Dave DeBusschere, Michelle McGann, Richie Guerin and John Havlicek.
2. Ed Sullivan, Martin Maddaloni, and Jim Grogran, leaders of the Building and Construction Trades Department
of the AFL-CIO, at the cocktail reception.
3. Committee Co-chairmen Ronald Kochman and Michael Singer accept awards for their generous participation.
4. Gibraltar Bank Putting Contest winner Gary Fujawa of the International Association of Heat and Frost
Insulators and Asbestos Workers shows off his new golf clubs.
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3.
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4.
A N N U A L D R I G O L F C L A S S I C PAY S T R I B U T E T O
A Night to Treasure
Harold Kart
Poker Run Proves
It’s All in the Cards
Bedazzles Broward Set
Upon arrival at the Museum of Art, Fort Lauderdale, guests of A Night to Treasure,
“Raiders of the Lost Art,” a unique cocktail party featuring live music, hors d’oeuvres and a
silent auction, were handed a sealed envelope and instructed not to peek inside until the race
began. Although dashing through a museum might sound unusual, it was the main objective
at this November event. The anticipation grew steadily as approximately 200 adventurers
awaited the evening’s main draw, an exciting hunt for hidden treasure. According to event
chairpersons, Pam Bernstein and Holli Rovenger, the event raised more than $43,000.
1) The entire committee united on stage to present the day’s
proceeds to Robert A. Pearlman.
2) Committee member Allen Jacobson (right) introduces Harold
Kart’s wife and son, Tina and Darren.
3) For the second year, Donna and Jerry Weiss took home the
award for Couple’s First Place.
4) Committee Co-chairman Jeff Zane (right) with his
winning foursome.
1.
“In your possession, everyone should have a clue card, containing four riddled clues and
the game rules,” said Colleen Rossano, treasure hunt chairperson. “You might run into a
snafu along the way to throw you off the trail, but the first team to match all of their clues
with the respective art pieces will win the grand prize. Let the sleuthing begin!”
Contestants flooded the stairwell and elevators on their way to the many featured exhibits,
including Pablo Picasso’s prized ceramic works. First, second and third prizes were awarded
to the quickest teams that found all clues successfully. Additionally, two consolation prizes
were extended through a random drawing. The program concluded with a few words by
Robert A. Pearlman.
“The Institute has achieved many milestones that only a few years ago were thought impossible. In fact, I am happy to report that today we have a number of people who have battled
diabetes for decades living insulin-free due to the latest protocol at the DRI,” he said. “Our
work can continue thanks to your generosity.”
As the committee for the Fourth Annual DRI Golf Classic began planning for the
upcoming tournament, they were dealt some horrible news. One of their most dedicated and hard-working members, Harold Kart, had passed away. In honor and memory of
their beloved friend, Co-chairmen Gary Studley and Jeffrey Zane and the rest of the
committee decided this year to rename the event the Harold Kart Memorial Golf
Classic. Featuring friendly competition on the greens of the Weston Hills Country Club,
followed by a touching dinner presentation, the November event raised more than
$140,000.
“The DRI was a cause very near and dear to Harold’s heart, and it warms mine to
2.
see you all here today,” said Kart’s wife, Tina, at the awards dinner. “On behalf of my
husband and myself, I sincerely thank you for being here.”
The day began with a hearty brunch at the Country Club. Guests passed through the
club’s beautiful atrium for morning registration and to purchase tickets for the money
board, which offered chances to win a variety of prizes. Eager golfers arrived early to
1.
practice their swings on the driving range, but at 12:30 p.m., all 180 participants
headed out to the course for a shotgun start. After the tournament, guests reconvened
at the club for cocktails and awards dinner.
Many generous individuals and companies lent their support to this tournament,
3.
including Marilyn and Gary Studley, The Estate of Mabel B. Conklin, Mutual of America,
2.
Debbie and Lou Steiner, Autohaus Pompano Mercedes-Benz, JM Lexus, Wendy and Avron
Fogelman, Graphics Illustrated, Myra and Allen Jacobson, and Rochelle and Gary Katz.
year’s event such a success. Proceeds from the 2002 tournament by far exceeded last
1) Committee members (l-r): Bonnie Gaines, Toni Nieves, Elyce
Weiner, Carolyn Brewer-Davila, Mari Blumstein, Holli Rovenger,
Pam Bernstein, Colleen Rossano, and Gale Goldstein Tucker.
Not pictured: Margaret Alperstein, Wendy Berman, Susan
Canarick, Robert Damigella, Audrey Dunn, Marc Morris
and Gina Stelnik.
year’s results of $85,000.
2) Committee chairpersons Pam Bernstein and Holli Rovenger
flank Carol Guzzo, of Citrix Systems, Benefactor Sponsor.
A special thanks is extended to all the committee members who helped make this
3) Roy Ripak, of Walgreens, Presenting Sponsor,
with his wife, Nancy.
3.
4.
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1.
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2.
1)Founder Phil Peterson (center) enjoys the weekend festivities
with his sons Drew (left) and Dirk (right).
2) Volunteer Morty Blumberg sells T-shirts to cyclists at Harley
Davidson South.
With poker faces on and engines revved,
approximately 10,000 motorcyclists jumped on
their hogs and headed from Miami to Key West
for the 30th Annual Harley Davidson Poker Run.
Some traveled in packs, some were lone riders,
but all made their way along the same scenic
strip of US 1 with the hope of being dealt a winning hand. This year’s event raised more than
$25,000 for the DRI.
“The first year, we had 46 participants,” said
Poker Run founder Phil Peterson, owner of Phil
Peterson Harley Davidson. Since its inception,
the Run has raised more than a million dollars
for a variety of local charities. “The second year,
we had 200 participants, and the following year
that number doubled.”
Continuing to gain in popularity, the Poker
Run is an exciting, rolling card game, where riders stop at local establishments along the route
to draw what they hope will be a winning poker
hand. The annual pilgrimage, which began on
Friday, September 20th, kicked off three days of
festivities, which included bike shows, celebrations and a Sunday morning “blessing of the
bikes” on Mallory Square. Throughout the weekend, the event attracted leather-clad bikers from
across South Florida and occupied eight blocks
of Key West’s famous Duval Street, which was
closed to outside traffic.
For the first time this year, bikers had the
opportunity to win a Harley of their choice or
$20,000. A poker hand of three-of-a-kind or
better gained participants a roll of the dice and a
chance to win the coveted prize.
A Gift of Love, A Gift of Hope
Honors a Dear Friend
“Help Find A Cure” Through New Internet Connection
More than 100 women filled Boynton Beach’s Benvenuto banquet hall, decked with an
array of shopping boutiques, to purchase their last minute holiday gifts and to raise money for
a very worthy cause. On Monday, December 9th, the Palm Beach County Auxiliary, a fundraising group for the Diabetes Research Institute Foundation, presented the fourth annual A Gift
of Love…A Gift of Hope Luncheon, in memory of founding member Estelle Nemery. The
afternoon event also included a delightful lunch, raffle
drawings and card playing.
Robert A. Pearlman presents thank you gifts to Luncheon Co-chairpersons (l-r) Sylvia Zemel and Ethel Kapner, and Auxiliary
Chairperson Renee Aronin.
1) Are you currently connected to the Internet? Check Below
Yes_____ No______ Are you planning to in the near future? Yes_____ No_____
2) Who is your current Internet Service Provider?
AOL____ EarthLink _____MSN____ Other_______ None_______
“Estelle was a dear friend of mine, and I know how much this cause meant to her,” said
Ethel Kapner, luncheon co-chairperson who began the program by reading a poignant letter,
written by Nemery’s daughter, Dr. Robin Nemery, a nationally known pediatric endocrinologist
affiliated with the Institute. “‘My mother was a very compassionate person, and I thank you all
for being here, in her honor and in support of the DRI,’” she read.
3) How do you connect to the Internet?
Dial-up_____ DSL______ Cable TV_______ Satellite_____ Other______
Co-chairperson Sylvia
Zemel continued the program by introducing Robert A. Pearlman.
“For the past four years, I’ve come to this luncheon to tell you about
the dream of islet cell transplantation. This dream is now becoming a
reality for many,” stated Pearlman. “Because of this amazing scientific
breakthrough, we have a number people off insulin.”
Boutique merchants included The Perfect Answer, Star Gems,
Bejeweled, Fashion Concepts, Personally Yours, Must Have
Accessories, Echo Jewelry, and Design Studio-Art Jewelry by Elaine.
Raffle prizes included jewelry, gift certificates, and more. Following
the program and lunch, the ladies enjoyed playing card games, such
as canasta, mah-jongg, and pan.
The ladies of the Palm Beach Auxiliary, pictured left to right: Shirley Lippsett, Judi Platt, Mariana
Sherman, Mona Posner, Sylvia Zemel, Ethel Kapner, Theda Handler, Sandy Schaeffer, Phyllis Braun,
and Shirley Zarider. Not pictured: Cynthia Kushlin, Renee Aronin, and Shirley Zarider.
Serving Up a Spoonful of Success
“If I could go one day without being a
diabetic, it would all be worth it. That’s what
I used to say,” stated Craig Menke, a loving
father of four, a devoted husband to wife
Natasha and owner of The Serving Spoon
restaurant in Sarasota, Florida. The phrase
is something he used to say before receiving
new islet cells as part of the DRI’s ongoing
clinical trials. Although at the time he was
still awaiting another transfusion of cells,
Menke, who was diagnosed with Type 1
diabetes in 1990 at the age of 21, enjoyed
multiple days off insulin. “Now, I hope to
raise awareness and funds and help others
attain that same dream.”
The Serving Spoon owner Craig Menke (center)
and his parents, Linda and Frank Menke, prepare
to greet the brunch bunch.
Following through on that initiative, the
novice fundraiser held a $100 per plate
brunch at The Serving Spoon, one of two
popular neighborhood restaurants with a
loyal clientele. The event, held Sunday,
December 1st, attracted more than 100
diners, who noshed on a delectable array of
house specialties, including stuffed salmon
benedict and fluffy buttermilk biscuits.
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Thanks to
good friends
and sponsors,
the inaugural
event raised
more than
$15,000.
Menke generFrank Menke, longtime DRI supously donated
porter Nate Esformes and Robert
A. Pearlman enjoy the restaurant’s
100 percent
turnout.
of the day’s
profits to the DRI. Due to the event’s
tremendous success, he plans on making it
an annual affair at both of his local eateries.
“After discovering the Institute on the
Internet, I realized that it is the best
hope for a cure,” said Menke. “Every single
person involved – from the physicians,
scientists and researchers to those working
at the Foundation – is doing everything they
possibly can to cure this horrible disease.”
If you’re like most people today,
you use the Internet for just about
everything. Now, you can log on and
help fund the DRI, too, through a new
Internet Service Provider (ISP).
The Diabetes Research Institute
Foundation is considering offering our
supporters who use the Internet the
opportunity of switching from their
current ISP, such as AOL, MSN,
Earthlink, etc., to an alternative
service provider.
The advantage to our donors is that
they could purchase a comparable
service to the one they currently use at
a less expensive monthly fee of $19.99.
The advantage to the DRI Foundation
is that we would receive up to 20
percent of the monthly fees paid by
the subscribers.
Before deciding to proceed,
we would appreciate receiving your
feedback. Please assist us by taking a
few moments to complete the following
survey and return it to the
DRI Foundation either by fax at
954-964-7036, in the business reply
envelope provided, or visit
www.drinet.org/survey.
4) If you had the option to receive the same features and benefits that your current Internet
Service Provider offers today, and pay less for the service, knowing up to 20 percent of
your payment would go to a good cause like the Diabetes Research Institute Foundation,
would you be willing try a comparable DRI Internet service?
Definitely______ Most Likely_____ Likely _____ Not Likely_____ No_____
5) How frequently do you use the Internet to communicate via email?
Daily_____ 2-3 times a week_____ Monthly_____ Never_____
6) How often do you use the Internet to find information, make reservations, on-line
purchasing etc.?
Daily_____ Two-three times a week_____ Monthly________ Never_______
7) Would it be important to you, if you knew you were supporting the DRI, by simply
purchasing your Internet Service through the DRI, knowing it was reliable, with more
features and would cost less than you are pay today?
Yes__________ No_____________
8) What are the most important features of your Internet Service or email to you?
Content____ Reliability_____ email space_____ Speed______ Customer Service_____
Name: _______________________________________________________________________
Address: _____________________________________________________________________
City: ________________________________ State: _________________ Zip:______________
Phone: _____________________________ E-mail: __________________________________
Thank you!
Thank you!
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