Caudalie Scientific conference on Resveratrol, September 26, 2013

LIVE OLDER,
YOUNGER,
MORE THAN A DREAM, A REALITY
Resveratrol
is at the heart of many
research projects on aging
Scientific conference, September 26, 2013 - Paris
This brochure is environmentally friendly.
It is printed on paper which comes from sustainably managed forests (FSC*).
* Forest Stewardship Council
www.caudalie.com
LIVE OLDER, YOUNGER
1. RESVERATROL’S SECRET
OR THE POWER OF SIRTUIN GENES
 THE NEVER ENDING QUEST
FOR MORE TIME AND MORE LIFE
to begin to understand the role of these genes in
Improving health and prolonging life represent a fun-
Where does their name come from? SIRT or SIR2
damental desire of most human beings. With the tre-
stands for Silence Information Regulator Two. This fa-
mendous progress made in the past years relative to
mily of human Sirtuin genes, for which 7 different types
life-threatening diseases, the focus today is now also
have already been identified2, is widely expressed in
turning towards maintaining a healthy and youthful ap-
fetal and adult tissues and probably holds the keys to
pearance. Each time information is shared on a subs-
human health and longevity.
tance that may have anti-aging properties, it begins to
One of the most exciting findings about these proteins
receive massive attention. This was the case for the
is that their enzymatic activity requires the presence of
Mediterranean diet and the famous “French paradox”
a small molecule called NAD+ (Nicotinamide Ade-
concerning wine and resveratrol. Since then, resvera-
nine Dinucleotide), a co-enzyme found in living cells
trol continues to be the subject of intense research
and involved in many metabolic reactions. This asso-
and is beginning to show the world the breadth and
ciation between SIR2 and NAD helped scientists to
depth of its unique and amazing anti-aging properties.
gather further information on potential links between
 THE SURPRISING ROLE OF SIRTUINS
ON AGEING
While we know that part of our ageing process is related to lifestyle and disease prevention, the role of
specific genes that influence longevity is just beginning
to be analyzed more deeply. Discovered first in yeast
in 1984 and then in humans in the early ‘90s, research
on longevity genes or sirtuins is now part of today’s
fastest moving areas of science and biology. Thanks to
their publication of the cover article of the March ’06
issue of Scientific American on the secrets of sirtuin
genes, DA Sinclair and LP Guarente allowed the world
1
extending human lifespan1.
diet and aging as observed during calorie restriction3.
But their story is not limited to aging and calorie
restriction; sirtuins have in fact pleiotropic biological
properties4 that include free radical scavenging, metal
chelation, cell signaling modulation and the inhibition
of inflammatory mediators. Among the proteins that
have been identified as targets for sirtuins are some
that are known to control critical processes concerning cell reproduction. These proteins can either set a
threshold for apoptosis, also called programmed cell
death, or prompt cell repair by buying time for those
cells that may have been damaged or weakened, so
that they can function properly again. Sirtuin genes are
particular the cognitive decline linked to Alzheimer’s
even involved in the activities of the power houses of
disease, its inhibitory activities on cyclooxygenase and
cells or mitochondria that supply the energy cells need
pro-inflammatory mediators.
to carry out their functions.
Controversies exist relative to this agent. From them
More than 10,000 papers have been published on this
scientists are noting that resveratrol works better in
topic with an increasing number of human studies that
people who need it the most. Specifically, metabolic
are starting to shed light on what the future may hold
decline is significantly more reduced in people who do
for mankind. New objectives include finding ways to
not exercise, have elevated blood sugar levels or are
activate these longevity genes for therapeutic purposes.
old as if resveratrol were programmed to correct cer-
 THE UNRIVALED POWERS OF
RESVERATROL AS AN ACTIVATOR
OF SIRTUINS PRODUCTION
Resveratrol found in the skin of grapes and more particularly in vine stalks is a polyphenol antioxidant that
can increase the production of sirtuin genes. Resvera-
tain imbalances. Most importantly however, this amazing treasure that is abundantly found in grape vines
has even more to offer to those who are seeking to
look young because its bioavailability is proportionally
greater when used in cosmetic products vs. dietary
supplements.
trol is the best known natural compound that exerts
a stimulatory effect on these genes. It is also this activity that allows resveratrol to promote longer cell
life. Thus, we now know that it is scientifically possible
to delay the aging process, perhaps even reverse it.
Countless articles have been published on resveratrol’s cardiovascular benefits, its effects on neural
tissue to prevent neurodegenerative diseases and in
2
1. DA Sinclair, LP Guarente, Unlocking the Secrets of Longevity Genes, Scientific
American, 2006, 294/48-51, 54-57
2. B. Morris, Seven sirtuins for seven deadly diseases of aging, Free Radical
Biology and Medicine, March 2013, 56, 133–171
3. J Auwerx et al., The NAD+/Sirtuin Pathway Modulates Longevity through
Activation of Mitochondrial UPR and FOXO Signaling, Cell, 18 July 2013, 154,
Issue 2, 430-441
4. Joseph A. Baur, Zoltan Ungvari, Robin K. Minor, David G. Le Couteur & Rafael
de Cabo, Are sirtuins viable targets for improving healthspan and lifespan?,
Nature Reviews Drug Discovery, June 2012, 11, 443-461
LIVE OLDER, YOUNGER
2. THE SCIENCE BEHIND
CAUDALIE’S RESVERATROL
 THE EARLY DAYS
skin tightness and elasticity. Further research on Cau-
Everything started around the virtues of vines.
dalie’s stabilized Resveratrol has opened new doors
Caudalie began in 1993 to explore the exceptional
so that consumers can benefit from its many different
virtues of the family vineyards by extracting polyphe-
properties including its anti-glycation properties.
nols from the grape seeds, stabilizing them and using
them for their exceptional properties to protect the
skin from oxidation (4 out of 5 wrinkles are due to
oxidation). Indeed, grape polyphenols are considered
3
 NEW INSIGHTS INTO THE ROLE OF
RESVERATROL ON GLYCATION ARE
STRENGTHENING ITS UNIQUE PROMISES
TO CONSUMERS
to be among the most potent antioxidants available
Glycation is a chemical reaction that is similar to what
from plants.This led to the discovery of the benefits of
happens to foods that are subject to intense heat lea-
resveratrol on prolonging the lifespan of skin cells. The
ding to browning or burning. This reaction with foods
extensive research carried out by J.Vercauteren on the
is called the Maillard reaction. It is due to the fact that
biological properties of polyphenols, including their
sugars or starches become glycated and form what
anti-proliferative and pro-apoptotic effects1, allowed
is called Advanced Glycation End products (AGEs).
and continues to allow science to offer explanations
When this happens in the body, biomolecules no lon-
for the efficacy of Resveratrol in Caudalie’s wide range
ger function properly. In particular, glycation contri-
of skin care products.
butes to a breakdown in the skin of both collagen and
As of 1997, Caudalie was the first to use resveratrol in
elastin. This means that skin will start to lose its fir-
skincare products.The form of Resveratrol that is used
mness, become dry and form wrinkles. Scientists have
in Caudalie’s skin care products is extracted from vine
shown that resveratrol can counteract the mecha-
stalk, stabilized and patented. Its unique bioavailability
nisms triggered by AGE interaction on dendritic cells2.
properties allow it to be effective throughout the lifes-
Thanks to resveratrol, skin can now be protected from
pan of epidermal cells, to protect skin cells from free
these devastating effects as it has shown remarkable
radicals and get the skin fibroblasts to produce more
anti-glycation properties that prevent undesired che-
good quality collagen and elastin fibers for enhanced
mical reactions.
 NO OTHER AGENT THAN
RESVERATROL HAS GENERATED AS
MUCH HOPE AGAINST AGEING
ANTI-GLYCATION ACTIVITY
OF CAUDALIE’ STABILIZED RESVERATROL
The anti-glycation properties of resveratrol represent
a major component. The following potential medical
applications are listed only to highlight how important
resveratrol has become to help fight, not just the aesthetic problems linked to ageing skin, but also some of
the medical concerns that come with increasing age.
Articles have been published on the impact of glycation on bone quality in patients with diabetes, meaning that resveratrol may lead to compounds to fight
osteoporosis among these types of patients. Other
studies are looking into the impact of AGEs on atrial
fibrillation, pulmonary disorders and inflammation.
 RESULTS FROM RECENT STUDIES
CARRIED OUT ON CAUDALIE’S
RESVERATROL
Recent scientific studies conducted on Caudalie’s
Resveratrol have just provided additional factual information on why consumer observations that their appearance has improved are not just subjective. More
specifically, a test conducted on skin in vitro shows that
Caudalie’s Resveratrol can increase skin epidermis
density by up to +53% in just 3 days. Sirtuin activation
was also quantified in this test and showed a +556%
increase in the amount of sirtuin surface in the epidermis with a 31% decrease in the amount of wrinkles as
measured after 28 days2.
1. C Barjot, M Tournaire, C Castagnino, C Vigor, J Vercauteren, JF Rossi, Evaluation
of antitumor effects of two vine stalk oligomers of resveratrol on a panel of
lymphoid and myeloid cell lines: comparison with resveratrol Life Sci. 2007 Nov
30;81(23-24):1565-74
2. Brigitta Buttari et al, Resveratrol Prevents Dendritic Cell Maturation in Response to Advanced Glycation End Products, Oxidative Medicine and Cellular
Longevity Volume 2013, Article ID 574029, 12 pages
3. KI Tanaka ,T Yamaguchi ,H Kaji ,I Kanazawa, T Sugimoto, Advanced glycation
end products suppress osteoblastic differentiation of stromal cells by activating
endoplasmic reticulum stress, Biochem Biophys Res Commun. 2013 Aug 7w
4
In this experimental context we can observe an anti-glycation
activity of 57,6% for resveratrol
LIVE OLDER, YOUNGER
3. DERMATOLOGICAL
PROPERTIES OF RESVERATROL
 WHAT ARE THE CURRENT TRENDS
WITH REGARD TO THE ENHANCEMENT
OF SKIN BEAUTY?
Life expectancy is getting longer every day. According
to the latest United Nations report, this trend is global, unprecedented in the history of humanity and is
increasing. The number of people aged 60 and above
is expected to double between 2000 and 2050 to
reach a peak number of around 2 billion1. But the story about aging is not just about an increasing number
of people living longer, it is also about living longer
in good health and looking young. The desire to look
good as one gets older has led to a multibillion dollar
beauty industry.
Consumer demand for cosmetic surgery and other
aesthetic medicine procedures has never been so high
and continues to grow at exponential rates. They still
want to get rid of the sagging skin, wrinkles and many
other signs of aging but the final result has to be natural. New trends include less invasive rejuvenation
methods. Medical devices based on laser, ultra-sound,
Intense Pulsed Light (IPL) or infrared technologies are
offering such alternatives. As they claim various bene-
5
fits from facial rejuvenation to body shaping, the need
for dermo-cosmetic products after such treatments
has never been so great.
 IS IT POSSIBLE FOR RESVERATROL TO
BE CONSIDERED AN IDEAL SKIN ACTIVE
MOLECULE?
First of all, the anti-oxidant properties of this natural
compound are so powerful that there simply are no
other botanical agents that can provide the same benefits to the skin. R Baxter’s comprehensive literature
reviews2, research and observations on patients have
greatly contributed to a deeper understanding of the
anti-aging properties of resveratrol both in wine3 and
in skin care products.
Furthermore, resveratrol is at the origin of a host of
many other biological anti-ageing processes that help
to confirm its credibility. It not only protects the skin
against age related changes at molecular level but also
against the damaging Ultra Violet rays from exposure
to the sun. Its anti-oxidant activities last throughout
the 21 day average lifespan of skin cells before they
are naturally renewed.
 RESVERATROL OFFERS SPECIFIC
ADVANTAGES TO PEOPLE FROM VARIOUS
AGE GROUPS
 RESVERATROL AS A NEW SOLUTION
TO HYPERPIGMENTATION AND PHOTODAMAGE IN SKINS OF ALL COLORS
Resveratrol is effective in restoring the elasticity and
The effect of resveratrol in reducing post-acne hy-
natural beauty of youthful skin through its direct effect
perpigmentation or common pigmentation disorders
on fibroblasts responsible for the renewal of collagen
seen by dermatologists in skin of color4 is most likely
and elastin that determine the skin’s structure. These
linked to its anti-inflammatory properties. Its ability to
activities are even enhanced through the ability of res-
prevent UV induced skin photo-damage is related to
veratrol to stimulate sirtuin genes involved in various
a whole series of different types of activities that can
steps of the aging process. Caudalie’s stabilized Resve-
be attributed to polyphenols including the inhibition
ratrol has been shown to both be effective to correct
of certain cellular signaling pathways and mitogen acti-
wrinkles and preventing it. In 2012, Caudalie conduc-
vated protein kinases (MAPs).
ted a study (for 3 months with 25 volunteers) with the
department of Dermatology and the Department of
Genetic and Genomic Sciences at Mount Sinai Hospital in New York USA to determine the efficiency of
Caudalie anti-wrinkle products containing stabilized
Resveratrol.
6
1. http://www.who.int/ageing/about/facts/en/index.html - last accessed on 18
September 2013
2. RA Baxter, Anti-aging properties of resveratrol: review and report of a potent
new antioxidant skin care formulation, J Cosmet Dermatol, 2008 Mar, 7(1):2-7
3. RA Baxter, Age Gets Better With Wine – New Science for a Healthier, Better
& Longer Life, The Wine Appreciation Guild, ISBN: 978-1934259-24-5
4. S Konda, AN Geria, RM Halder, New Horizons in Treating Disorders of Hyperpigmentation in Skin of Color, Semin Cutan Med Surg, 31:133-139
LIVE OLDER, YOUNGER
THE PROSPECT OF LIVING TO THE AGE OF 100 AND
AWARENESS LEVELS OF RESVERATROL
in the USA1, Great Britain1, France2, Germany2, Italy2 and Spain2
Study conducted by IFOP and Harris Interactive for Caudalie
 PERSONAL PREDICTIONS ABOUT ONE’S LIFE EXPECTANCY
Question: Do you think you will live to be 100 years old?
NEARLY 1 OUT OF 4 PEOPLE THINK THEY WILL LIVE TO BE 100 YEARS OLD
7
1. Americans are more optimistic than Europeans!
3 out of 10 Americans think they will live up to 100 years (29%). The Spanish (27%) come next, followed by the
Italians (26%), the French (24%) and the English (19%). But the Germans are the most pessimistic about their
chances to live up to 100 years (17%).
2. The younger we are, the more we imagine we will be able to live up to 100 years old
In all six countries, younger adults aged 18-34 are more likely to think they will live to be 100 years.
• 44% in the USA, significantly more than those aged 35-44 (25%), 45-54 (23%) or 55+ (22%).
• 33% on average for France, Germany, Spain, Italy (4 consolidated countries), more than those aged 50-64 (19%).
The older you get, the less you imagine yourself as a centenarian. However, there is hope to age to 65 and older
(23%).
• 29% in Great Britain, more than those aged 45+ (16%).
3. Men are more optimistic than Women about their longevity
For all 6 countries, Men, especially younger adults (18-34), believe they are more likely to live up to 100 years old.
• In the USA, Men aged 18-34 (48%) are more likely to report this than men aged 35+ (25%). Women aged
18-34 (41%) are more likely to think they will live to be 100 years old than women aged 35+ (21%). Men are
more likely to indicate this than women (32% vs. 27%, respectively). Those who are single/never married (40%)
are more likely to think this than those who are married or divorced/separated/widowed (both 25%).
• 37% on average for France, Germany, Spain, Italy (4 consolidated countries), more than Women (31%)
• In Great Britain, Men are more likely to think they will live to be 100 than women (22% vs. 15%, respectively).
4. Interesting findings about European countries (France, Germany, Spain, Italy) :
• The more you are satisfied with your appearance, the more you imagine you will live to be old (41% extremely
satisfied, 24% quite satisfied, 17% not really satisfied, 15% extremely dissatisfied).
• The more you have a low body-mass index, the more you believe you will be a centenarian (31% thinness, 25%
normal body weight, 23 overweight, 16% obesity).
FOCUS ON FRANCE
The French still among the least optimistic in Europe but there’s an improvement!
In 8 years*, the optimism of the French increased regarding their longevity.
While in 2005 only 18% of the French imagined themselves centenarians,
they are almost 1 out of 4 French today (24%)!
Source IFOP - Evolution between 2005 and 2013 of the proportion of French who think they will live to be a hundred
8
 AWARENESS OF RESVERATROL:
Question: Have you ever heard of Resveratrol?
MORE THAN 8 OUT OF 10 PEOPLE DON’T KNOW WHAT RESVERATROL IS…
However, resveratrol is one of the molecules the most studied by researchers!
A MAJORITY OF AMERICANS AND EUROPEANS NEVER HEARD OF RESVERATROL
On average over the six countries, only 15% of people surveyed say they have heard of resveratrol, even with
a very low score of 5% in Great Britain. Spanish and Italians are champions all categories combined for their
knowledge of resveratrol, ahead of the United States. France is in third position in Europe. Interestingly, the three
European countries who know quite well resveratrol are Latin countries where the grape has a real cultural significance. Moreover, these are also the countries where we see the greatest longevity.
1. Paradoxically, the younger we are, the more we have heard about resveratrol…
• In Great Britain, those aged 18-24 (14%) or 45-54 (7%) are more likely to say that they have heard of resveratrol than those aged 55+ (2%). Those aged 18-24 are also more likely to have ever heard of resveratrol than
those ages 35-44 (3%).
• For the 4 other European countries, resveratrol has the best awareness levels among the under 35, especially
the 18-24 (19%).
2. … except in the USA
• Older individuals aged 55+ are more likely to have heard of resveratrol than those aged 18-44 (22% vs. 14%,
respectively). Those who live in the West of the USA (22%) are more likely to indicate that they have heard of
resveratrol than those who live in the South (15%).
FOCUS ON LIFE EXPECTANCY
(UNITED NATIONS – 2011):
Italy: 82 years ; Spain: 82 years ;
France: 82 years ; Great Britain: 80 years ;
United States: 79 years
9
3. Women know more about resveratrol
• In the USA interestingly, women aged 35+ (23%) are more likely to report this than women aged 18-34 (10%).
Those who are married (21%) or divorced/separated/widowed (22%) are more likely to have heard of resveratrol than those who are single/never married (11%).
• In Great Britain, households with children are more likely to report that they have never heard of resveratrol
than households without children (9% vs. 4%, respectively).
• For the 4 other European countries, resveratrol is known both by men and women, SPC+, with a very slight
advantage for women.
FOCUS
Focus on the detailed awareness of resveratrol in France, Italy, Spain and Germany
Among the people surveyed and who have heard about resveratrol (16%):
• Resveratrol is recognized first as a beneficial molecule derived from the vine and
grapes (59%)
• Resveratrol is also recognized as a component of wine with protective properties,
especially for the cardiovascular system (53%)
• And resveratrol is recognized as a natural cosmetic ingredient with anti-ageing
properties (47%)
METHODOLOGY:
1. For U.S. and Great Britain: Harris Interactive® for Caudalie
• United States - Survey Methodology: This survey was conducted online within the United States between from August 21st–23rd, 2013 among 2,034 adults ages
18 and older by Harris Interactive on behalf of Caudalie USA via its Quick Query omnibus product. Figures for age, sex, race/ethnicity, education, region and household
income were weighted where necessary to bring them into line with their actual proportions in the population. Propensity score weighting was used to adjust for
respondents’ propensity to be online.
• Great Britain - Survey Methodology: This study was conducted online by Harris Interactive on behalf of Caudalie USA among a total of 1,034 adults aged 18+
within Great Britain from August 20-23, 2013 via its Global Omnibus product. Figures for age, sex, education and region were weighted where necessary to bring
them into line with their actual proportions in the population. This data were weighted to reflect the composition of the general adult population.
2. For France, Germany, Italy and Spain: IFOP for Caudalie
• Sample: Sample of 4006 people representing people in France, Germany, Italy and Spain aged 18 and over.
The interviews were broken down as follows: 1002 interviews in France; 1000 interviews in Germany ; 1004 interviews in Italy ; 1000 interviews in Spain. Quotas
were used to ensure that the samples used were properly representative (sex, age and profession of the respondent) after stratification by region.
• Data collection method: The interviews were conducted using self-administered on-line questionnaires (CAWI - Computer Assisted Web Interviewing).
• Survey dates: 29 August to 4 September 2013
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LIVE OLDER, YOUNGER
QUESTIONS & ANSWERS
 HOW EFFECTIVE IS RESVERATROL IN SKIN CARE PRODUCTS COMPARED TO
RESVERATROL FROM DIETARY SUPPLEMENTS?
The benefits are complementary. Many scientific studies show the health benefits of drinking red wine. To obtain
a global effect without drinkring wine, dietary supplements are an interesting alternative. For a very targeted
effect on skin, the use of cosmetic creams containing Resveratrol will be very useful. Resveratrol reaches higher
concentrations when applied directly. Caudalie has several patents on its use of resveratrol (a unique stabilized
form) that has proven its efficiency on skin aging signs.
 ARE THERE OTHER COMPANIES THAT ARE USING RESVERATROL IN THEIR SKIN CARE
PRODUCTS AND IS THEIR ACTIVE INGREDIENT THE SAME AS CAUDALIE’S?
Other companies are using resveratrol in skin care products. However, Caudalie’s Resveratrol is unique thanks to
its form which is stabilized for an exceptional bio-availability. Caudalie’s stabilized Resveratrol is patented.
 WHAT ARE THE SCIENTIFIC DISCOVERIES ABOUT RESVERATROL THAT WERE
INITIALLY MADE BY CAUDALIE?
Caudalie’s first skin care products highlighted resveratrol’s unique ability to fight visible signs of skin aging including
wrinkles, thin and sagging skin. New properties that are being developed are linked to the recently discovered
anti-glycation activities of resveratrol. Glycation reduces the skin’s ability to regenerate the collagen fibers that
provide the underlying support to prevent wrinkles, looseness and dryness. This chemical process occurs when
sugar molecules attach themselves to proteins leading to irreversible bonds that can make the skin stiff and fragile.
Caudalie’s Reseratrol has shown that it has the ability to avert glycation induced damage to the skin’s structure.
11
 IS CAUDALIE STILL INVESTING IN RESEARCH ON RESVERATROL AND WHAT ARE THE
CURRENT SCIENTIFIC RESEARCH PROGRAMS?
All Resveratrol properties have not been fully explored yet. Caudalie is continuing to invest in research in general
and in the anti-glycation properties of its Resveratrol in particular. New highly potent molecules are in the pipeline.
 AT WHAT AGE SHOULD ONE START TO USE RESVERATROL-BASED SKIN CARE
PRODUCTS?
Some dermatologists and plastic surgeons will encourage patients to start taking care of their skin on a regular
basis as soon as they turn 20. Today, it is recognized that the earlier consumers start caring for their skin, the
better they will be able to prevent the signs of age over time. Caudalie’s products containing stabilized Resveratrol (Vinexpert and Premier Cru ranges) are adapted to women to correct the aging signs (lack of firmness,
wrinkles…). For younger women, Caudalie proposes other products in particular formulas concentrated in antioxidant grape seeds polyphenols or soothing, hydrating grape water.
 WHAT IMPACT DOES AGE HAVE ON HOW MUCH A USER OF A RESVERATROL-BASED
PRODUCT CAN EXPECT TO GAIN?
The evaluation of the efficacy of skin care products is both scientific and personal. Each consumer will make his
or her own judgment of the improvements in appearance that their use of Caudalie products has offered to
them. Scientific studies as well as consumer testimonials indicate that Caudalie’s stabilized Resveratrol can make
a visible positive difference in skin appearance (less visible wrinkles, more skin tonicity, tone and skin radiance…).
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LIVE OLDER, YOUNGER
GLOSSARY OF COMMON TERMS
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AGEs
Advanced Glycation End products. These products are formed when sugars or starches
are glycated or irreversibly bound to certain proteins during certain chemical reactions
such as the Maillard reaction.
APOPTOSIS
Naturally programmed cell death. Products that inhibit apoptosis prolong the life of cells
by preventing their natural death.
BIOAVAILABILITY
This term refers to how well and how fast a substance is absorbed in the body so that
it can be used by the target tissue. Regarding Caudalie’s stabilized Resveratrol, its lipid
soluble properties allow it to quickly penetrate the skin and remain there to exert antioxidant activities that prevent premature aging. For orally absorbed forms of resveratrol,
only a fraction gets into the blood stream from where it can be delivered to the site
where it is expected to release its specific benefits.
COLLAGEN
Specific fibrous proteins that are abundantly present in the extracellular matrix and
connective tissue. These proteins provide structure, firmness and elasticity to skin. With
age, collagen production decreases in quantity and in quality allowing wrinkles to form as
the skin becomes thinner, weaker and stiffer.
CYCLOOXYGENASE
An enzyme or a COX that can lead to the formation of biological mediators involved in
pain and inflammation. Products that inhibit these enzymes can also provide relief from
such symptoms.
DERMIS
This is the middle layer of the skin sometimes called the dermal layer. It contains the
blood vessels, nerves, hair follicles, sweat glands fibroblasts and collagen bundles. This
where the skin’s strength and elasticity are determined.
ELASTIN
This is a protein that is also produced by the fibroblast cells and directly responsible for
the level of skin elasticity.
EPIDERMIS
Outer layer of the skin consisting essentially of dead cells that have migrated up to the
surface of the skin where they form a protective shield preventing bacteria, excess water
and other elements from entering into the body.
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FIBROBLASTS
The most common cells of connective tissue in the body. Their shape can vary according
to their location but they are in general quite large and elongated cells.
They are important for the production of collagen which provides structure to the skin
and elastin which helps to keep the skin flexible.
GLYCATION
A reaction between proteins and sugars. The most well-known glycation reaction is the
Maillard reaction that accounts for the brown color that starts to form when foods are
overcooked. Glycation has a negative impact on skin in that it induces fibroblast apoptosis
or programmed cell death. This leads to thin, stiff and older looking skin.
GRAPE SEEDS
Grapes have been used for over a thousand years for various nutrition as well as medicinal
purposes. The fact that their seeds contain ingredients to help prevent diseases or treat
certain medical conditions has led to the production of products based on grape seed
extracts. Caudalie however derives its resveratrol from group stalks and not from grape
seed because the grape stalks Resveratrol has shown to be more potent for use in
dermo-cosmetic preparations.
GRAPE STALKS
It is known for its very high resveratrol content. Although resveratrol is quite present in
grape skin, it is in the grape stalks that one finds the highest concentrations and the type
that is used in Caudalie’s dermo-cosmetic products.
MAPs
Mitogen Activated Protein kinases are involved in cellular signal transduction pathways.
They play a role in directing certain biological functions such as cell growth, differentiation
and apoptosis.
METABOLISM
A process by which substances in the body undergo change. The process is a chemical
transformation or enzyme-catalyzed reaction in which organic matter is either being
broken down or constructed to generate nucleic acids and proteins.
MITOCHONDRIA
Also called the power houses of cells.This is where the energy, that allows a cell to divide,
move around, live and carry out specific functions, is located.
POLYPHENOLS
A clustering of large groups of phenol structures or phenolics that are chemical
compounds with a hydroxyl group (-OH) and a carbon group. Phenolics exist naturally in
plants and animals but can also be produced. Many plant polyphenols are powerful antioxidants that protect against oxidative stress.
RESVERATROL
A powerful anti-oxidant found mainly in plants and particularly in grape vines that also
activates sirtuins. Caudalie uses a patented form of Resveratrol that it extracts from
grape stalks. The efficacy of this active ingredient is related to its potent anti-oxidant
properties, its ability to avert glycation and activate sirtuin genes that slow down the
aging process in general.
SIRTUINS
Sirtuins Silent Information Regulator Two genes also written as SIRT or SIR2. They are
widely expressed in fetal and adult tissues and appear to hold the keys to human health
and longevity. Reveratrol has been shown to activate these genes thereby offering a
specific opportunity to fight ageing.
LIVE OLDER, YOUNGER
JOSEPH VERCAUTEREN
I studied at the Faculty of Pharmacy of Reims in France in 1977 and received my Master’s degree in Chemistry of Natural Substances in 1978, and then my PhD in 1979.
Both provided me with a mastery of the most modern analytical techniques including
MNR with the IEF located in Orsay, France and X-Ray diffraction from the ICSN located in Gif-sur-Yvette, France.
In 1979, I started a thesis, with the CNRS, on total synthesis of anti-leukemia alkaloids
and received my Post Doc degree in 1983. I then became a Research Fellow with the
CNRS following my thesis and a NATO scholarship allows me to do a one year Post
Doc internship (1983-1984) within the Department of Chemistry headed by Professor Trost at the University of Wisconsin, in Madison,Wisconsin, USA on the substitution
by phenols of the π-allyl palladium complex and total synthesis of complex alkaloids.
Professor of Pharmacognosia at the Faculty of Pharmacy of Bordeaux since 1988, I
developed for 15 years research on polyphenols (vines, cocoa, …). I installed the first
spectrometer MNR 500 MHz available for the South of France (1989) that allowed
us to develop 2D heteronuclear methods for the analysis of procyanidolic oligomers
(natural polyphenols).The quality of our work was recognized by the following awards
and prizes: thesis prize of the Division of Organic Chemistry of the SFC, Palaiseau in
2000 and 2 AOCS prizes of which the “Honored Student Award” and the “Manuchehr
Eijadi Award”, San Diego, 1999. Our partnership with the founders of Laboratoire
Caudalie started in 1995.
In Montpellier (2002), I have been orienting my research activities towards the study of
biological properties of polyphenols in cancer and metabolic disorders, neurodegenerative and cardiovascular diseases. In 2011, we integrated the department of bioactive
lipids of the IBMM, UMR CNRS # 5247 of Thierry Durand along with the INSERM
Unit of Dr C Hamel focusing on Stargardt’s disease.
Author of 27 patents and PCTs, 1120 international publications, I have been invited
to speak at 80 international and 57 national conferences. I have followed 18 university
doctoral students and 17 DEA and Master’s degree students.
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LIVE OLDER, YOUNGER
DAVID A. SINCLAIR
David Sinclair, Ph.D. is a Professor at Harvard Medical School in the Department
of Genetics and is co-Director of the Paul F. Glenn Laboratories for the Biological
Mechanisms of Aging.
At M.I.T., he worked with Lenny Guarente and co-discovered a cause of aging for
yeast and the role of Sir2 in epigenetic changes during aging that gave rise to a new
field called the “sirtuins”.
His lab at Harvard Medical School works primarily on understanding the basis of
aging and its reversibility, with interests in chromatin, energy metabolism, mitochondria, neurodegeneration, and cancer. His lab first showed that sirtuins are mediators
of calorie restriction’s benefits in mammals and contributed to the understanding
of how sirtuins are modulated by endogenous molecules such as nicotinamide and
NAD+. His lab also discovered that sirtuins can be activated by small molecules
such as resveratrol.
Dr. Sinclair is Co-Chief editor of the journal Aging and has received awards including
the Commonwealth Prize, a Helen Hay Whitney Postdoctoral Award, a Leukemia
Society Fellowship, a Ludwig Scholarship, a Harvard-Armenise Fellowship, an American Association for Aging Research Fellowship, The Nathan Shock Award from NIH,
Scholarships from The Ellison Medical Foundation, The Merck Prize, the Genzyme
Outstanding Achievement in Biomedical Science Award, a “Bio-Innovator award”.,
the David Murdock-Dole Lectureship, the Fisher Lectureship at UCLA, and a MERIT
Award from NIH.
He has co-founded a number of biotechnology companies including Sirtris (2005),
Genocea (2006), Cohbar (2010) and OvaScience (2012).
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LIVE OLDER, YOUNGER
RICHARD A. BAXTER
Dr. Baxter is a board-certified plastic surgeon who has been practicing in the Seattle area for 20 years. He has been recognized as an expert in plastic surgery and antiaging by local and national broadcast media. He serves on the Emerging Trends
Committee and the Spokespersons Network for the American Society of Plastic Surgeons, and the Innovative Procedures Committee of the Aesthetic Surgery
Research Foundation. Dr. Baxter is also a member of the International Society of
Aesthetic Plastic Surgery, and is a clinical educator for several cosmetic surgery and
nonsurgical products and procedures.
As the author of the award-winning book “Age Gets Better with Wine: New Science
for a Healthier, Better, and Longer Life”, Dr. Baxter has a thorough knowledge of the
exciting and sometimes controversial developments in anti-aging science based on
wine.
As former clinical faculty member of the University of Washington School of Medicine, Dr. Baxter has pioneered several new techniques and published extensively. His
articles have been cited more than 200 times and he has lectured on wine & health,
innovation, skin care, and plastic surgery around the world.
Dr. Baxter was the Founding Medical Director of Calidora Skin Clinics (now Skin
Spirit.)
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