DIAGNOSIS

AUTOIMMUNE DISORDERS
- A Highly Variable Group...
Complex Manifestations...Periodic Episodes...Overlap Syndrome
DIAGNOSIS
Therefore is Challenging
Resolve the complexity with VIMTA's HEURISTICS
A Rational Approach
By
COMPREHENSIVE PANELS
For
Screening
Diagnosis
Confirmation
Monitoring
Risk Prediction
Indicating Extent of Overlap Syndrome
Accurate...Differential...Definitive...Diagnosis...
KEY HIGHLIGHTS
EXTENDED IMMUNE PROFILE PANEL
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Wide Spectrum of Range Offerings
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Highly specific markers combined to form Rational Panels
CD19, CD3, CD4, CD8, CD16+56
?
Panels offering advantages of diagnosing Overlap Syndrome
?
Enumeration of entire lymphocyte subsets by Flowcytometry: B cells, T cells (with
?
Intra and Inter Panel advantages
CD4/CD8 counts) and NK cells
?
Fast TAT
?
Useful assay in work up of patients born with congenital immunodeficiency states
?
Comprehensive and conclusive diagnosis in the backdrop of clinical history
?
Useful in patients suffering from secondary immunodeficiency states induced due to
immunosuppressive therapy or HIV infection
ANA BLOT CAPSULE I
ANA BLOT CAPSULE II
ANA, ds-DNA, SS-A, SS-B, RNP-G
SS-A, SS-B, RNP-G, SCL 70, JO1
?
Useful test for complete workup of suspected
SLE patients
COLLAGEN CAPSULE
ARTHRITIS CAPSULE
?
Useful panel to differentiate between SLE,
Scleroderma and Inflammatory Myopathies
(dermatomyositis and polymyositis)
?
To diagnose SLE, spontaneous SLE, annular
variety of subacute cutaneous SLE, Neonatal
Lupus Erythematosus
?
To help in diagnosis of mixed connective tissue
disorders having features of SLE, Scleroderma
and Polymyositis
?
SS-A, SS-B and RNP are more specifically
associated with SLE
?
SCL-70 is a common association with
Scleroderma
ANA, ds DNA, ANCA, C3, C5, CRP, RF, UA
?
To confirm diagnosis for Systemic Lupus
Erythematosus
Inflammatory Myopathies
?
Panel of Biochemical and Immunological
markers to screen for diseases affecting joints
?
To diagnose Vasculitis, Rheumatoid Arthritis and
?
JO-1 is almost exclusively associated with
ASO, ANA, C4, CRP, UA, Ca, RF, UR
Gout
?
Screening test for Autoimmune Disorders,
Rheumatoid Arthritis, Gout
?
Overlap Syndrome of Musculo-skeletal Disorders
SLE CAPSULE
Also Available : STAND ALONE TEST RANGE
CBP, ESR, Creatinine, RA, ASO, ds-DNA
?
To screen for SLE, Rheumatoid Arthritis and previous Streptococcus Pyogenes Infection
?
Also indicates extent of muscular and renal involvement
HLA B-27
tTG
AUTO HEP
?
Primarily ordered to help strengthen or confirm a
?
Less Invasive blood test for screening celiac
disease, other gluten-sensitive conditions
?
Anti-tissue Transglutaminase Antibody (tTG) :
IgA - Highly specific serologic markers for celiac
diseases and dermatitis herpetiformis
?
Anti-Gliadin Antibodies (AGA):
IgG - More sensitive for screening the patients at
risk for Celiac Disease and diagnosing gluten
sensitive enteropathies
IgA- monitoring patients on gluten free diets
CCP ANTIBODIES
ANA, AMA, ASMA, LKM-1
?
Overlap of Primary Biliary Cirrhosis and
Autoimmune Hepatitis
?
To diagnose Primary Biliary Cirrhosis
?
To distinguish Autoimmune Hepatitis from other
causes of liver injury or disorder
?
To screen for autoimmune diseases, chronic
active hepatitis,extra hepatic biliary
obstruction,non obstructive biliary tract
disease,viral hepatitis and cryptogenic cirrhosis
suspected diagnosis of seronegative
inflammatory arthropathies like Ankylozing
Spondylitis, Reiters Syndrome and Anterior Uveitis
?
Dignose and evaluate conditions causing arthritis
?
Predictive Marker for Risk Assessment
?
Advantage of performing the test both on PCR
and Flowcytometry
?
Disease specific autoantibody in early cases of
RA, where clinical symptoms are milder and nonspecific
?
Superior to IgM RF in predicting an erosive
disease course.
?
Valuable in providing diagnostic, prognostic and
therapeutic information in patients with
Rheumatoid Arthritis
?
95-98% Specificity
COMPREHENSIVE STAND ALONE TEST RANGE
TEST CODE
562
85
42
583
45
46
47
49
51
54
55
57
43
564
59
95
90
91
107
603
482
329
369
371
377
392
393
274
INVESTIGATION
Anti-Gliadin IgA, IgG Antibody
Acetyl Choline Receptor Antibody
Anti ds DNA Antibody-Qual, Quant
Anti Endomysial Antibody IgA, IgG
Anti Mitochondrial Antibody
Anti Mitochondrial Antibody Titre
Anti Neutrophill Cytoplasmic Antibody(p-ANCA/c-ANCA)-Qual,Quant
Anti Nuclear Antibody
Anti Nuclear Antibody -Qual, Quant
Anti Smooth Muscle Antibodies-Qual, Quant
Anti Sperm Antibodies
Anti Streptolysin O Titre
Anti TPO
Anti Transglutaminase IgA, IgG Antibodies
Anti Thyroglobulin Antibodies
c-ANCA
C3- Complement 3
C4- Complement 4
Cardiolipin Antibodies-IgA, IgG, IgM
CCP Antibodies
Circulating Immune Complex
P-ANCA
RF-IgA, IgG, IgM Antibodies
Rheumatoid Factor RA Test
Scl 70 IgG Antibodies
SS-A (Ro) IgG Antibodies
SS-B (La) IgG Antibodies
Jo-1 Antibodies
For more information on Sample Collection, contact at:
VIMTA LABS LTD.
®
Life Sciences Facility, CLINICAL REFERENCE LABORATORY
5, Alexandria Knowledge Park (Formerly S.P. Biotech Park),
Genome Valley, Hyderabad- 500 078, India.
Phone: +91-040-67404020, +91-040-67404040, +91-0120-2424086
URL: www.vimta.com, email: [email protected]