final_programme - Österreichische Gesellschaft für Allergologie
Transcription
final_programme - Österreichische Gesellschaft für Allergologie
Österreichische Gesellschaft für Allergologie und Immunologie & Deutsche Gesellschaft für Immunologie JOINT ANNUAL MEETING OF IMMUNOLOGY OF THE AUSTRIAN AND GERMAN SOCIETIES Lecture Centre of the Vienna General Hospital Vienna, Austria Wednesday, September 3 – Saturday, September 6, 2008 Final Programme www.medacad.org/oegai2008 ALLERGIE LAUF Sonntag, 7. September 2008 Schlosspark Schönbrunn Hiermit laden wir Sie ganz herzlich dazu ein, im Anschluss an den Kongress „Joint Annual Meeting of Immunology, Wien, 3.-6. September 2008“, am ALLERGIE LAUF am Sonntag, 7. September 2008 im SCHLOSSPARK SCHÖNBRUNN, einer der schönsten Parkanlagen Wiens, teilzunehmen. Nach dem Startschuss von Nobelpreisträger Peter Doherty geht es durch den Schlosspark Schönbrunn, durch Alleen mit barocker Gartenbaukunst, und vorbei am Schloss Schönbrunn, einem der bedeutendsten Kulturdenkmäler Österreichs, einst bewohnt von Kaiserin Sissi und heute ein beliebtes Ausflugsziel vieler Wiener und Wienbesucher. Sie können unter verschiedenen Distanzen wählen und auch im Team laufen. Das Tempo bleibt Ihnen überlassen: gemütlich oder mit sportlichem Ehrgeiz, dazu wird es eine exakte elektronische Zeitmessung geben. Ob Kongressteilnehmer oder nicht - es sind alle eingeladen, mit zu laufen. Im Anschluss an den Lauf folgen als Krönung des Tages und als Belohnung für Ihren sportlichen Einsatz und das tüchtige anfeuern Ihrer Fans, die After Running Party, die Siegerehrung, eine Tombola, ein Buffet reich an köstlichen typisch österreichischen Gerichten, und eine Musikshow. Es unterhalten Sie Harry Sonnek und der legendäre Dave Dee, der mit seinen besten Songs aus den 60ern aus London zu uns kommen wird und für die richtige Partystimmung sorgen wird. Zur After Running Party sind alle Läufer und deren Begleiter ganz herzlich eingeladen. Bitte nutzen Sie die Möglichkeit der Online-Anmeldung auf www.medacad.org/oegai2008 unter „Allergy Run“ sobald als möglich, damit Sie sich Ihr, in der Gebühr inkludiertes, Erinnerungs- T-Shirt in der richtigen Größe sichern. Auf der Homepage finden Sie auch alle mit dem Lauf verbundenen Informationen, sowie den vorläufigen Streckenplan. Wir freuen uns auf zahlreiche Anmeldungen! www.bundesgaerten.at Österreichische Gesellschaft für Allergologie und Immunologie & Deutsche Gesellschaft für Immunologie JOINT ANNUAL MEETING OF IMMUNOLOGY OF THE AUSTRIAN AND GERMAN SOCIETIES Lecture Centre of the Vienna General Hospital Vienna, Austria Wednesday, September 3 – Saturday, September 6, 2008 Final Programme www.medacad.org/oegai2008 Table of Contents 1 General Patronage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Welcome Addresses ......................................................... 3 Committees – Board – Organisation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Programme at a Glance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Scientific Programme - Wednesday, September 3, 2008 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 - Thursday, September 4, 2008 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 - Friday, September 5, 2008 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 - Saturday, September 6, 2008 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Poster Viewing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Business Meetings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 Satellite Lunch Symposia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Information on Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 Information for Speakers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 Information Congress Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Registration Fees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Venue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Social Events . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Underground Map . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 City Map . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Exhibition Exhibition – General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 List of Sponsors, Exhibitors and Advertisers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Patronage 2 Under the Patronage of Dr. Alfred Gusenbauer Federal Chancellor of the Federal Republic of Austria Dr. Johannes Hahn Federal Minister for Science and Research Dr. Andrea Kdolsky Federal Minister for Health, Family and Youth Mag. Sonja Wehsely Executive City Councillor for Public Health and Social Affairs Acknowledgements The Joint Annual Meeting of Immunology gratefully acknowledges the support of the following institutions, companies and organisations (list correct as per date of printing): Welcoming Addresses 3 Unquestionably a high level of health care is the core element of our modern welfare system as we know it. It is therefore our duty as politicians to secure the basis for its long-term financial stability. Furthermore, we must create an institutional and legal framework to guarantee universal and non-discriminatory access to all forms of treatment. Nobody should be excluded or left behind. Only under these conditions can health-care professionals fulfil their essential duty and live up to their oath i.e. helping people. Public opinion polls show the high satisfaction of Austrians with our national health care system. But no society can satisfy itself with self appreciation. Many challenges lie ahead of us. Some are institutional, financial, others are scientific. This congress will help to promote knowledge and hopefully inspire all working in your field. On behalf of the Austrian government it is my pleasure to welcome you here in Austria and in particular at this “Joint Annual Meeting of Immunology”. Dr. Alfred Gusenbauer Federal Chancellor of the Federal Republic of Austria More than 1000 participants at the „Joint Annual Meeting of lmmunology" give invigorating proof of the importance and international reputation of the Societies of Allergology and Immunology in Austria and Germany on the one hand and the Vienna Medical Academy in the fields of education/research as well as conference and association management – an organisation dedicated to serving the needs of the medical non-profit community - on the other. As minister of Science and Research it is good news for me that international experts are discussing such pressing topics as vaccination, infection and allergy just now in Austria. That means new incentives for the Scientific Community especially in our country and the opportunity to expand international networking. These issues are of great relevance for nearly all of us and the expectations are very high, if you only think of tumor immunology for example. May the meeting be a successful one with impressing results and congratulations on bringing together university professors of international reputation in this field in Vienna for the first time. In this way the meeting is a great recognition of Vienna as an important medical research place. Dr. Johannes Hahn Federal Minister for Science and Research Welcoming Addresses 4 Dear colleagues and scientific friends, It is our great pleasure to welcome you to the Joint Annual Meeting of the Austrian and the German Societies of Immunology in Vienna. The annual conferences of our societies allow for an exchange of thoughts and information on cutting edge developments taking place in the immunological laboratories worldwide. The format of a joint annual conference allows for an expansion of this exchange into a neighbouring country and likewise fosters new and/or permits to renew longstanding scientific and social relationships. With this meeting we are aiming to delineate the latest progress in our field, focusing on matters arising not only in basic innate and adaptive immunity, but also clinical immunology including novel therapeutic approaches. The scientific committee has invited outstanding scientists to present their thinking and to summarize data on their advances in plenary sessions and introductions to workshops. Within workshops and during the poster sessions, there will be ample opportunity especially for students and postdoctoral fellows to present their newest research results and thus a broad array of work which is performed in the realm of the hosting societies and beyond. We have made all efforts to create a scientific program that meets your expectations. In addition you shall enjoy Vienna´s ambience and hospitality, the unique culture and spirit which so few other cities have to offer. With best wishes for a scientifically exciting and stimulating meeting and mit herzlichen Grüßen, Yours Stefan Meuer & Josef Smolen Committees – Board – Organisation Congress Committee Stefan C.W. Meuer Andreas Radbruch Reinhold E. Schmidt Josef Smolen Marcus Säemann Local Organising Committee Irmgard Förster Beatrix Grubeck-Loebenstein Erika Jensen-Jarolim Stefan C.W. Meuer Winfried Pickl Andreas Radbruch Marcus Säemann Reinhold Schmidt Josef Smolen Hannes Stockinger Rudolf Valenta Gerhard Zlabinger ÖGAI Executive Committee Josef Smolen (President) Rudolf Valenta (President Elect) Beatrix Grubeck-Loebenstein (Past President) Marcus Säemann (Secretary General) Winfried Pickl (Deputy Secretary) Tamara Kopp (Secretary Protocol) Barbara Bohle (Treasurer) Gernot Achatz (Board Member) Hans-Peter Brezinsek (Board Member) Roswitha Gruber-Sgonc (Board Member) Erika Jensen-Jarolim (Board Member) Johannes Stöckl (Board Member) Martin Thurnher (Board Member) Othmar Förster (Honorary President) DGfI Executive Committee Stefan C.W. Meuer (President) Andreas Radbruch (President Elect) Reinhold E. Schmidt (Past President) Werner Solbach (Secretary General) Christian Bogdan (Board Member) Barbara Bröker (Board Member) Stefan Ehlers (Board Member) Irmgard Förster (Board Member) Reinhold Förster (Board Member) Stefan H. E. Kaufmann (Board Member) Heidrun Moll (Board Member) Yvonne Samstag (Board Member) Burkhart Schraven (Board Member) Hans Dieter Volk (Board Member) Hans-Martin Jäck (Board Member) Conference Organisation, Abstract Management, Sponsoring Vienna Medical Academy Ms. Marieke Hodel Alser Strasse 4, 1090 Vienna, Austria Phone: +43 1 405 1383-10; Fax: +43 1 407 8274 E-mail: [email protected] Exhibition Management Hotel Accomodation Medizinische Ausstellungs- und Werbegesellschaft MAW Freyung 6 A-1010 Vienna, Austria Phone: +43 1 536 630 Fax: +43 1 535 60 16 E-mail: [email protected] Mondial Congress & Events Operngasse 20b 1040 Vienna Phone: +43 1 58804-0 Fax: +43 1 58804-185 Email: [email protected] Congress Venue Lecture Centre of the Vienna General Hospital (Allgemeines Krankenhaus - AKH) Währinger Gürtel 18-20 1090 Vienna, Austria 5 Workshops Parallel Symposium 2: In vivo imaging Parallel Symposium 2: Vaccination Parallel Symposium Vaccines & Adjuvants Autoimmunity I NK cells Immunomodulation Lecture Hall 4 Welcome Reception at the Vienna City Hall Parallel Symposium 2: Immunomodulation Break & Poster Viewing Signal Transduction Tumor Immunology Break & Poster Viewing Parallel Symposium 1: Tumor Immunology Lecture Hall 3 Satellite Lunch Symposium Lecture Hall 2 Parallel Symposium 1: Innate Immunity: Antigen-PresentingCells T-Lymphocytes II Satellite Lunch Symposium: B cell: Promising target in autoimmune diseases (Roche) Plenary Session 19.00 14.00 – 15.30 15.30 – 16.30 16.45 – 18.00 12.15 – 13.45 T-Lymphocytes I Parallel Symposium 1: T-Cell Signaling 08.15 – 09.30 09.30 – 10.30 10.30 – 12.15 Lecture Hall 1 Time Thursday, September 4, 2008 Followed by Welcome Drinks Opening by Wolfgang Schütz (Rector of the Medical University of Vienna) Vienna Philharmonic Keynote Lecture: Nobel Laureate Peter Doherty Vienna Philharmonic Awarding of the Landsteiner Medal of the ÖGAI to Ron Germain Awarding of the Landsteiner Price of the DGfI to Max Cooper Karl Landsteiner (1868-1943) - An Austrian Immuno-Pathologist (G. Schmidt-Wyklicky) Welcome and Opening Stefan Meuer, President DGfI Josef Smolen, President ÖGAI 15.00 – 15.10 15.10 – 15.25 15.25 – 15.45 15.45 – 16.05 16.05 – 16.20 16.20 – 16.50 16.50 – 17.00 17.00 – 17.15 Lecture Hall 1 Time Wednesday, September 3, 2008 Programme at a Glance Veterinary Immunology Innate Immunity: Antigen-Presenting Cells Lecture Hall 5 6 Regulatory Lymphocytes I Allergy I Parallel Symposium Best Poster Awards Klinische Fälle aus der Allergologie: Wie hätten Sie entschieden? Workshops General Assembly ÖGAI Autoimmunity II Satellite Lunch Symposium: Vom rekombinanten Allergen zu neuen Allergietherapien (Phadia) Break Lecture Hall 2 Parallel Symposium 1: Inflammation Lecture Hall 1 Parallel Symposium 1: Autoimmunity Plenary Session Time 08.45 – 10.00 10.00 – 10.30 10.30 – 12.15 12.15 – 12.45 12.45 – 13.00 13.00 – 13.45 14.00 – 14.30 15.00 Parallel Symposium 2: Adaptive Immunity: B-Cells Break & Poster Viewing Regulatory Lymphocytes II Alloimmunity & Tolerance Break & Poster Viewing Lecture Hall 3 Parallel Symposium 1: Transplantation Mucosal Immunity Pattern Recognition Receptors & Myeloid Cells Lecture Hall 4 Satellite Lunch Symposium Infection II Break Lecture Hall 3 Parallel Symposium 1: Allergy Break Complement System Lecture Hall 4 Departure with buses to the Viennese “Heuriger” Fuhrgassl-Huber Parallel Symposium 2: Adaptive Immunity: Regulation Parallel Symposium 2: Infection General Assembly DGfI Allergy II Infection I Satellite Lunch Symposium: Immune modulation with intravenous Drittmittelförderung der DFG: Kriterien immunoglobulin: the established and the advances (Octapharma) für eine erfolgreiche Antragstellung Lecture Hall 2 Parallel Symposium 1: Mucosal Inflammation Lecture Hall 1 Parallel Symposium 1: Innate Immunity: Regulation Saturday, September 6, 2008 Time 08.15 – 09.30 09.30 – 10.30 10.30 – 12.15 12.15 – 13.00 13.00 – 13.45 14.00 – 15.30 15.30 – 16.30 16.45 – 18.00 18.00 – 19.30 19.30 Friday, September 5, 2008 Programme at a Glance Cytokines, Chemokines & their receptors Lecture Hall 5 B-Lymphocytes Innate Immunity: Regulation Lecture Hall 5 7 Scientific Programme – Wednesday, September 3, 2008 Time Lecture Hall 1 15.00 15.10 Welcome Chair: S. Meuer, J. Smolen Welcoming addresses by Stefan Meuer, President DGfI Josef Smolen, President ÖGAI 15.10 15.25 Karl Landsteiner (1868-1943) - An Austrian Immuno-Pathologist Gabriela Schmidt-Wyklicky 15.25 15.45 Awarding of the Landsteiner Price of the DGfI to Max Cooper Laudatio: Andreas Radbruch Award Lecture: Max Cooper 15.45 16.05 Awarding of the Landsteiner Medal of the ÖGAI to Ron Germain Laudatio: Clemens Scheinecker Award Lecture: Ron Germain 16.05 16.20 Rainer Honeck, Concert Master of the The Vienna Philharmonic Orchestra: J.S. Bach 16.20 16.50 Keynote Lecture: Nobel laureate Peter Doherty 16.50 17.00 Rainer Honeck, Concert Master of the Vienna Philharmonic Orchestra: F. Kreisler 17.00 17.15 Opening by Wolfgang Schütz (Rector of the Medical University of Vienna) 17.15 Welcome Drinks 8 Scientific Programme – Thursday, September 4, 2008 Time 08.15 09.30 09.30 10.30 Lecture Hall 1 Lecture Hall 2 9 Lecture Hall 3 Parallel Symposium 1: T-Cell Signaling Chair: W. Pickl, D. Kabelitz Parallel Symposium 1: Innate Immunity: Antigen-PresentingCells Chair: G. Stingl, B. Broeker Parallel Symposium 1: Tumor Immunology Chair: E. Jensen-Jarolim, G. Riethmüller Molecular determinants of Inside-out signaling in T-cells B. Schraven DC dependent maintenance of peripheral regulatory T-cells S. Beissert Human Self/Tumor Antigens and Tumor Immunosurveillance O.J. Finn From T cell activation signals to signaling control of anti-cancer immunity J. Penninger Role of antimicrobial peptides in triggering The immune response to sporadic cancer autoimmunity T. Blankenstein M. Gilliet Deciphering TCR ligand discrimination by combining experiments, computer modeling, and predictive simulations R. Germain TLR-activated dendritic cells as effector cells of the immune response G. Stingl Coffee Break / Poster Viewing / Exhibition Development of DNA vaccination strategies for pediatric cancers H.N. Lode Scientific Programme – Thursday, September 4, 2008 Time 10.30 12.15 Lecture Hall 1 Lecture Hall 2 Lecture Hall 3 Lecture Hall 4 10 Lecture Hall 5 T-Lymphocytes I Chair: G. Schütz, H. Wolf Autoimmunity I Chair: H. Strobl, G. Beilhack Tumor Immunology Chair: J. Singer, T. Weichhart Immunomodulation Chair: K. Loser, W. Berger Innate Immunity: Antigen-Presenting Cells Chair: N. Romani, H. Schild 1. Increased Th17 and decreased CD4+FoxP3+ T regulatory cells in third trimester pregnancies with pre-eclampsia B. Santner-Nanan, M. Peek, L. Richarts, R. Khanam, E. Zhu, B. Fazekas de St. Groth, R. K. Nanan 9. The role of B cells in tissue draining lymphnodes for the development of collagen induced arthritis (CIA) C. Scheinecker, A. Rapp, M. Bonelli, A. Savitskaya, J. S. Smolen 17. Higher avidity of TCR-gene-modified T cells by using parts of the murine constant TCR regions D. Sommermeyer, W. Uckert 25. Regulation of homing receptor expression in CD4+ T cells B. A. Ratsch, C. Doebis, S. Jennrich, S. Floess, A. Hamann, U. Syrbe 33. Targeting of Haemagglutinin antigen to C-type Lectins on human Dendritic Cells elicits different T cell responses in vitro G. F. Heidkamp, F. Nimmerjahn, A. Piperno, H. Zebroski, R. M. Steinman, M. C. Nussenzweig, D. Dudziak 2. Blockade of inducible costimulator (ICOS) inhibits accumulation of polyfunctional Th1/Th17cCells and prevents autoimmune arthritis O. Frey, J. Meisel, L. Bruns, A. Hutloff, L. Morawietz, T. Kamradt 10. T helper cells only induce acute inflammation but B cells are necessary for the induction of chronic Antigen-induced Arthritis M. Janke, T. Hohnstein, L. Morawietz, A. Scheffold 18. Reprogramming T cells to become MHC independent - electroporation of RNA encoding chimeric antigen receptors N. Schaft, T. Schunder, C. Krug, S. Reuter, D. Kosmides, H. Abken, M. Kershaw, E. Kämpgen, G. Schuler, J. Dörrie 26. Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases J. Pruessmeyer, R. Koenen, L. Fraemohs, O. Soehnlein, C. Weber, A. Ludwig 34. PPARgamma enhances uptake and cross-presentation of soluble antigen in dendritic cells S. Hucke, J. Floßdorf, I. Dani, D. Thimm, A. Kautz, C. Kurts, P. Knolle, L. Klotz, S. Burgdorf 3. IRF4 is essential for IL-21-mediated induction, amplification and stabilization of the Th17 phenotype M. Huber, A. Brüstle, A. Guralnik, A. Mahiny, E. von Löw, M. Lohoff 11. Crucial role of CCR4 in the development of experimental CNS autoimmune disease by modulation of Treg cell compartimentalization J. Alferink, D. M. Otte, K. Poppensieker, Ö. Yilmaz, A. Mildner, M. Prinz, W. Maier, A. Zimmer 19. Memory CD8+ T-cell mediated tumor rejection is impaired in NKG2Ddysfunctional mice M. C. Banerjea, D. Sigurdardottir, B. Pömmerl, H. Rammensee, A. Steinle 27. Ontogeny of Langerhans cells in prenatal human skin C. Schuster, C. Vaculik, C. Fiala, W. Eppel, S. Meindl, M. Imhof, A. Elbe-Bürger 35. Genomic RNA of human rhinovirus - a ”semi-danger-signal” for dendritic cells C. Schrauf, S. Kirchberger, O. Majdic, J. Seipelt, J. Stöckl 4. Acid sphingomyelinase is a critical regulator of cytotoxic granule secretion by primary T lymphocytes J. Herz, J. Pardo, H. Kashkar, M. Schramm, E. Kuzmenkina, E. Bos, K. Wiegmann, R. Wallich, P. J. Peters, S. Herzig, E. Schmelzer, M. Krönke, M. M. Simon, O. Utermöhlen 12. Antigen-specific TGF -induced Treg suppress Th17-mediated autoimmune disease E. N. Huter, G. H. Stummvoll, E. M. Shevach 20. Rejection of established cancer: Lack of IFN- , TNF- and Fas-ligand but not perforin by effector CD8+ T cells allows cancer to progress J. J. Listopad, G. Willimsky, B. Silkenstedt, T. Kammertöns, T. Blankenstein 28. Requirement of CCL17 for progression of atopic dermatitis and contact hypersensitivity in mice S. Stutte, N. Gerbitzki, I. Förster 36. Antagonism between GATA-1 and vitamin D3 receptor in myelopoisis and dendritic cell subset differentiation S. Taschner-Mandl, F. Göbel, M. Kumerz, J. Jurkin, C. Vaculik, S. Richter, C. Bieglmayer, A. Elbe-Bürger, H. Strobl 5. Adenosine regulates CD8 T cell priming by inhibition of membraneproximal T cell receptor signaling D. Stabenow, C. Linnemann, F. A. Schildberg, A. Schurich, S. I. Hegenbarth, L. Diehl, E. Endl, S. Lacher, C. E. Müller, J. Frey, L. Simeoni, L. Simeoni, B. Schraven, P. A. Knolle 13. The pathogenic role of HnRNP-A2 in Pristane-induced arthritis M. H. Hoffmann, C. Baumann, B. Meyer, G. Steiner 21. Defects of the antigen processing machinery leading to T cell resistance of melanoma cells M. Keller, F. Ebstein, A. Paschen, E. Bürger, D. Schadendorf, P. M. Kloetzel, U. Seifert 29. Acid sphingomyelinase is required for efficient phago-lysosomal fusion M. Schramm, U. Karow, A. Haas, M. Krönke, O. Utermöhlen 37. Function of hypoxiainducible factor (HIF)-1 in dendritic cells T. Köhler, R. S. Johnson, H. Weighardt, I. Förster 6. pSMAC formation in human peripheral blood T-cells requires localization of the actin-bundling protein L-plastin to the immunological synapse G. Wabnitz, P. Lohneis, H. Kirchgessner, Y. Samstag 14. The autoimmune regulator Roquin-a cofactor for miRNA function? E. Glasmacher, K. P. Höfig, E. Kremmer, V. Heissmeyer 22. Tumor-specific T helper cells regulate tumor dormancy or progress multistage carcinogenesis through T cell cytokines H. Braumueller, T. Wieder, N. Bauer, M. Rocken 30. Phenotypic and molecular analysis of an HLA Class II deficient patient reveals a homozygous nonsense mutation in the CIITA gene at amino acid position 381 K. G. Schmetterer, M. G. Seidel, U. Körmöczi, K. Schwarz, S. MatthesMartin, P. Steinberger, W. F. Pickl 38. Distinct mechanism of antigen routing and cross-presentation in LSEC A. K. Schurich, J. Böttcher, S. Burgdorf, P. Penzler, S. Hegenbarth, D. Stabenow, A. Dolf, E. Endl, C. Kurts, P. A. Knolle Scientific Programme – Thursday, September 4, 2008 (continued) 11 Lecture Hall 1 Lecture Hall 2 Lecture Hall 3 Lecture Hall 4 Lecture Hall 5 7. The effect of thymectomy in early childhood on the naive T cell compartment in later life M. Prelog, M. Keller, R. Geiger, A. Brandstaetter, R. Würzner, B. Grubeck-Loebenstein, L. B. Zimmerhackl 15. OSCAR, a key costimulation molecule for osteoclasts, is induced in patients with rheumatoid arthritis S. Herman, G. Krönke, R. Müller, J. Zwerina, K. Redlich, G. Schett 23. Identification of tumor antigens using antibodies induced by dendritic cell (DC) based vaccines J. Leitner, A. Stift, J. Friedl, R. Pfranger, P. Steinberger, K. Pfistershammer 31. Different mechanisms of immunosuppression caused by Cyclosporine A (CsA) and FK506 T. Giese, C. Sommerer, C. Jacobi, M. Zeier, S. Meuer 39. Skin dendritic cells present lipid antigens to natural killer T cells P. Stoitzner, I. F. Hermans, N. Romani 8. Clonal evolution of the 16. Imaging immuneeffector T cell repertoire neuronal interactions in D. Zehn, M. J. Bevan experimental autoimmune encephalomyelitis using intravital two-photon microscopy V. Siffrin, J. Herz, T. Leuenberger, A. U. Brandt, H. Radbruch, R. Niesner, C. Infante-Duarte, F. Zipp 24. Serological relationship between cutaneous human papillomavirus types 5, 8 and 92 A. Handisurya, C. Schellenbacher, R. Gambhira, S. Shafti-Keramat, O. Forslund, M. Favre, R. Kirnbauer 32. Identification of three novel genes as biomarker for monitoring anti-TGFbeta therapy S. Classen, C. Muth, D. Eggle, M. Beyer, T. Zander, A. Staratschek-Jox, J. L. Schultze Time Lecture Hall 1 12.15 13.45 Satellite Lunch Symposium - Roche B cell: Promising target in autoimmune diseases Chair: J. Smolen The biology of the B cell in autoimmune diseases A. Radbruch Clinical experiences with B cell therapies T. Dörner Safety: Experiences with Rituximab H-P. Brezinsek Scientific Programme – Thursday, September 4, 2008 Time 14.00 15.30 Lecture Hall 1 Lecture Hall 4 12 Lecture Hall 2 Lecture Hall 3 Lecture Hall 5 T-Lymphocytes II Chair: M. Lohoff, A. Thiel Vaccines & Adjuvants Chair: B. Grubeck, S. Weiss Signal Transduction Chair: T. Bürckstürmer, T. Stulnig NK cells Chair: C. Watzl, M. Fischer Veterinary Immunology Chair: A. Saalmüller, M. Müller 40. Stability and flexibility of CD4 T cell differentiation programs in vitro and in vivo A. N. Hegazy, H. Hengartner, R. M. Zinkernagel, A. Radbruch, M. Löhning 48. Improvement of the Immunogenicity of a HIV-1 Clade C Candidate Vaccine increasing Gag, Pol, Nef and Env Specific T-Cell Responses J. Wild, J. Koestler, S. Bredl, K. Boeckl, R. Wagner 56. Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions M. Klemke, G. Wabnitz, F. Funke, B. Funk, H. Kirchgessner, Y. Samstag 64. The stress-inducible endogenous danger signals HSP70 and MICA synergistically activate the cytotoxic effector functions of human NK cells L. Elsner, P. F. Flügge, J. Lozano, V. Muppala, S. Y. Demiroglu, D. Malzahn, H. Bickeböller, G. Multhoff, L. Walter, R. Dressel 72. Charakterization of the chicken CD40CD40L system unsing the RCAS retroviral gene transfer technology K. Schenk-Weibhauser, J. Young, B. Kaspers, S. Kothlow 41. On the role of adipokines in Th2 lymphocyte polarization A. Batra, B. Okur, J. Ihbe, T. Stroh, R. Glauben, I. Fedke, M. Zeitz, B. Siegmund 49. Safety and immunogenicity in a phase I dose-escalation BPV-1 VLP vaccine trial in horses R. Kirnbauer, S. Brandt, S. Shafti-Keramat, E. K. Hainisch 57. The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development B. Reis, D. Finkenstaedt, D. K. Finlay, D. A. Cantrell, K. Pfeffer, S. Beer 65. Regulation of NK cell activity through extracellular HLA-B-Associated Transcript 3 E. Pogge von Strandmann, V. Simhadri, K. S. Reiners, H. P. Hansen, A. Engert 73. Analysis of potential antiviral MX activity in the chicken B. Schusser, N. Penski, A. Reuter, G. Kochs, P. Staeheli, B. Kaspers, S. Kothlow 42. In vivo generated Th17 cells have a stable memory for IL-17 expression M. H. Lexberg, I. Albrecht, A. Förster, A. Richter, A. Radbruch, H. D. Chang 50. Characterisation of effects on growth of Staphylococcus aureus mediated by specific IgGs B. Tosetti, E. Glowalla, M. Krönke, O. Krut 58. Micropatterning of CD4 in the live cell plasma membrane reveals novel binding mechanisms to Lck M. Schwarzenbacher, M. Kaltenbrunner, M. Brameshuber, C. Hesch, W. Paster, J. Weghuber, B. Heise, A. Sonnleitner, H. Stokkinger, G. J. Schütz 66. Natural killer cell’s activation by Immunomodulin for treatment strategy of recurrent genital herpes V. Garib, U. Djabborov, Y. Rasul-Zade 74. MHC typing in swine: SLA class I and class IIallele distribution in Austrian Large White, Landrace, and Pietrain breeding stocks S. E. Hammer, J. Deutsch, B. C. Rütgen, S. Groiß, W. Gerner, S. Müller, A. Saalmüller 43. Role of HDAC in T helper cell development R. Glauben, E. Sonnenberg, I. Fedke, P. Mascagni, M. Zeitz, B. Siegmund 51. Analysis of the mechanisms mediating dendritic cell-based vaccination against Leishmania major J. K. Schnitzer, C. Hambrecht, M. Fajardo-Moser, K. A. Remer, H. Moll 59. Stat3 serine 727 phosphorylation upon activated TLR binding promotes via MyD88/TRIF safekeeping of IL-1beta S. Dreher, F. Schmitz, R. Ferstl, S. Spiller, J. Marges, A. Heit, I. Förster, R. Lang, H. Wagner, C. J. Kirschning 67. Decision making in NK cells D. Urlaub, S. Mesecke, H. Busch, R. Eils, C. Watzl 75. Porcine coccidiosis adaptive immune response mechanisms against Isospora suis H. L. Worliczek, W. Gerner, A. Saalmüller, A. Joachim 44. Human CD4+CD25+Foxp3+ regulatory T cells efficiently inhibit GvHD induction in a humanized mouse model C. Becker, J. Kubach, C. Taube, C. Becker, K. Michel, K. Reifenberg, H. Jonuleit 52. Virus-like particles: A cell-free antigen-presenting platform modulating lymphocyte activation in vitro and in vivo H. J. Kueng, V. M. Leb, D. Haiderer, G. Raposo, C. Thery, S. V. Derdak, K. G. Schmetterer, A. Neunkirchner, C. Sillaber, B. Seed, W. F. Pickl 60. Carma1/Bcl10/Malt1 Complexes Transmit ITAM-coupled NK Cell Receptor Signals for NFB and MAPK Activation O. Groß, C. Grupp, C. Steinberg, S. Zimmermann, D. Strasser, N. Hannesschläger, W. Reindl, C. Peschel, A. Krug, J. Ruland 68. Natural killer cells are modulated in patients with neuroimmunologic disorders in response to treatment with intravenous immunoglobulin C. Jacobi, M. Claus, B. Wildemann, J. Römisch, C. Watzl, S. Meuer, T. Giese 76. Potential diagnostic markers for subclinical endometritis in cows: TNF-alpha, IL-1 alpha, IL-1 beta, and IL-8 C. Gabler, M. Drillich, C. Fischer, C. Holder, W. Heuwieser, R. Einspanier 45. Mathematical modeling of the diversity of the immunological synapse M. T. Figge, M. Meyer-Hermann 53. Priming and boosting of melanA-specific T cells - in vitro studies on the importance of antigen-presentation density J. Dörrie, N. Schaft, V. Wellner, C. Wohn, T. Schunder, I. Müller, E. Kämpgen, G. Schuler 61. Functional analysis of the riboflavin kinase and its role in TNF-induced signalling B. Yazdanpanah, C. Pongratz, K. Wiegmann, H. Kashkar, M. Krönke 69. Myeloid-Derived “Suppressor” Cells express Rae-1 and activate NK cells A. Cerwenka, E. Schlecker, I. Galani, N. Nausch 77. Toll-like receptor expression and bacterial strain dependent chemokine response in a primary bovine colonic epithelial cell culture model P. S. Bridger, M. Mohr, J. Fröhlich, H. Metcalfe, D. Werling, G. Baljer, C. Menge Scientific Programme – Thursday, September 4, 2008 (continued) 13 Time 15.30 16.30 Lecture Hall 1 Lecture Hall 2 Lecture Hall 3 Lecture Hall 4 46. The role of the zinc finger protein MAZR in CD4/CD8 cell fate decisions during thymocyte development S. Sakaguchi, I. Bilic, M. Hombauer, A. Schebesta, W. Ellmeier 54. Propagation-deficient LCMV-derived vaccine vector efficiently targets dendritic cells to induce potent T and B cell responses against immunogens of choice L. Flatz, A. N. Hegazy, A. Verschoor, A. Bergthaler, M. Löhning, D. D. Pinschewer 62. The DEAD-box helicase DDX3X is a critical component of the TANKbinding kinase 1-dependent innate immune response D. Soulat, T. Buerckstuemmer, S. Westermayer, A. Goncalves, A. Bauch, A. Stefanovic, O. Hantschel, K. L. Bennett, T. Decker, G. Superti-Furga 70. Characterization of a novel, RORgt-expressing mucosal NK cell population S. L. Sanos, A. Mortha, V. Bui, K. Oberle, A. Diefenbach 78. Analysis of CD28 in horses and application of a polyclonal Ab to induce co-stimulation S. Ibrahim, E. Abd El-Gawad, F. Steinbach 47. 2D-DIGE analysis of enriched secretory lysosomes of human T and NK cells H. Schmidt, C. Gelhaus, M. Lettau, M. Nebendahl, M. Leippe, O. Janssen 55. Vaccination with MHC class II-heterologous dendritic cells induces protective immunity against Leishmania major K. A. Remer, H. Moll 63. Post-transcriptional regulation of FasL expression: Molecular insights into storage, activation-induced mobilization and shedding of a prototypic death factor M. Lettau, O. Janssen 71. Specificity of interaction between killer cell immunoglobulin-like receptors (KIR) and MHC class I molecules of the rhesus macaque (Macaca mulatta) P. Kruse, C. Rosner, M. Hermes, L. Walter 79. Species-specific generation of immune regulatory molecules by host pathogen coevolution R. Kammerer, T. Popp, S. Haertle, B. B. Singer, E. Travanty, Z. Qian, K. V. Holmes, W. Zimmermann Coffee Break / Poster Viewing / Exhibition Lecture Hall 5 Scientific Programme – Thursday, September 4, 2008 Time Lecture Hall 1 16.45 18.00 Parallel Symposium 2: Vaccination Chair: M. Müller, H.J. Schild Parallel Symposium 2: In Vivo Imaging Chair: C. Scheinecker, C. Berek Parallel Symposium 2: Immunomodulation Chair: W. Ellmeier, E. Schmitt Delineation of plasmablast characteristics generated in steady-state and in systemic immune responses H. Mei The In Situ Dynamics of Innate and Adaptive Immune Cell Behaviour Revealed By Intravital Multiphotometry Microscopy R. Germain Probing Dendritic cell In vivo Functions S. Jung Towards a coronavirus- based multigene vaccine platform B. Ludewig In vivo imaging of Germinal Center B Cells Tec kinases in T cell activation and A.E. Hauser function L. Berg Modulating Vaccine Responses with Innate Immunity B. Pulendran Non-invasive imaging of inflammation the quest for specificity A. Wunder 19.00 Lecture Hall 2 14 Lecture Hall 3 Inducible Foxp3-dependent or -independent human CD4+ regulatory T Cells. R. Bacchetta Welcome Reception at the Vienna City Hall NUDIST COLONIES. CD-1-nude • NMRI-nude • BALB/c-nude We’ve improved the availability of our nude mouse strains. For more information, please contact us at: Call: +49 (0) 9761/ 406-0 • +31 (0) 43 40 77 310 E-mail: [email protected] • [email protected] [email protected] Scientific Programme – Friday, September 5, 2008 Time 08.15 09.30 09.30 10.30 Lecture Hall 1 Lecture Hall 2 15 Lecture Hall 3 Parallel Symposium 1: Innate Immunity: Regulation Chair: M. Säemann, W. Solbach Parallel Symposium 1: Mucosal Inflammation Chair: B. Bohle, D. Männel Parallel Symposium 1: Transplantation Chair: T. Wekerle, R. Schmidt Innate resistance, inflammation, and cancer G. Trinchieri Role of epithelial barrier function in allergy P. Brandtzaeg Antibody-mediated transplant rejection G. Böhmig Interferon regulatory factors and innate immunity in early life M. Goldman A prominent role for mucosal cystine/cysteine metabolism in intestinal immunoregulation S. Meuer Immune monitoring and therapy in transplantation - from bench-to -bedside H.D. Volk The mammalian target of rapamycin and innate immunity T. Weichhart Tumor Necrosis Factor and the consequences of its ablation in vivo S. Nedospasov Tolerance through mixed chimerism: how close to clinical application is it? T. Wekerle Coffee Break / Poster Viewing / Exhibition Scientific Programme – Friday, September 5, 2008 Time 10.30 12.15 Lecture Hall 1 Lecture Hall 2 Lecture Hall 3 Lecture Hall 4 16 Lecture Hall 5 Allergy I Chair: H. Renz, F. Horak Regulatory Lymphocytes I Chair: L. Klein, T. Wekerle Alloimmunity & Tolerance Chair: B. Arnold, H. Ankersmit Pattern Recognition Receptors & Myeloid Cells Chair: S. Bauer, C. Bogdan Innate Immunity: Regulation Chair: M. Zeyda, K. Pfeffer 80. Tracing antigen signatures in the human IgE repertoire K. Marth, M. Novatchkova, M. Focke-Tejkl, S. Jenisch, S. Jäger, D. Kabelitz, R. Valenta 88. Analyses of a novel regulatory T cell subset in patients with Systemic Lupus Erythematosus (SLE) M. Bonelli, A. Savitskaya, E. Feierl, S. S. Smolen, C. Scheinecker 96. Role of IL-2 in induction of CD8 T cell tolerance by LSEC A. K. Schurich, M. Berg, A. Limmer, H. J. Schild, L. Diehl, P. A. Knolle 104. Influence of viral infection on recognition of self RNA T. von Thülen, M. Nain, S. Bauer 112. Suppression of adaptive immune responses by Toll-like receptor ligands B. Schumak, M. Brock, F. Jüngerkes, G. Hartmann, T. Tüting, P. Knolle, R. Zawatzky, S. Bauer, A. Limmer 81. Stable dust challenge inhibits allergic airway reactivity through TLRs 2, 3, 4, 7, 9 and/or other PRRs/TLRs R. Ferstl, S. Spiller, S. Dreher, H. Garn, H. Fehrenbach, E. Von Mutius, H. Renz, H. Wagner, C. J. Kirschning 89. CD4+ CD25high regulatory T cells suppress T helper 1 but not T helper 2 cytokines T. Bollinger, A. Bollinger, W. Solbach 97. Proliferation of CD8positive T cells in the Lumina of Rat Renal Allograft Blood Vessels V. Grau, G. Fuchs-Moll, W. Padberg 105. TLR7-dependent recognition of transfer RNA Y. Zhao, A. Kaufmann, K. Steinbach, S. Bauer 113. The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells S. Kirchberger, O. Majdic, S. Blüml, C. Schrauf, J. Leitner, C. Gerner, W. Paster, N. Gundacker, M. Sibilia, J. Stöckl 82. Composition of B cell receptor classic antigen-binding site regulates allergic airway inflammation in a murine model of experimental asthma S. Kerzel, J. Wagner, T. Rogosch, A. Yildirim, H. Fehrenbach, H. Garn, R. F. Maier, H. W. Schroeder Jr., M. Zemlin 90. Induction of CD25Foxp3- regulatory T cells by chronic antigen stimulation in vivo W. Hansen, A. M. Westendorf, J. Buer 98. Dickkopf 3, a novel modulator of T cell responses M. Papatriantafyllou, G. Moldenhauer, H. J. Gröne, C. Niehrs, G. J. Hämmerling, T. Oelert, B. Arnold 106. Intrabody mediated retention of TLR2 and TLR9 in the ER to inhibit chronic inflammation T. Böldicke, S. Dreher, S. Somplatzki, L. Grosse-Hovest, B. Maaß, W. Lindenmaier, H. Wagner, C. Kirschning 114. Molecular mechanisms of Staphylococcus aureus-induced autophagy K. Sabel, D. Grumme, S. A. Leggio, A. Schnaith, M. Krönke, O. Krut 83. High expression of inflammatory cytokines, chemokines and their receptors in lungs of mice during allergic asthma remission underlies the persistence of chronic lung inflammation R. Bankoti, L. El-Housseiny, G. Dekan, O. Hoffmann, G. Stingl, M. M. Epstein 91. Transfer of in vitro expanded human CD45RA+CD4+CD25hig h regulatory T cells inhibits early expansion of conventional T cells in immunodeficient Rag2-/c-/- mice T. J. Boeld, J. Albrecht, K. Doser, R. Eder, J. Stahl, E. Typlt, E. Obermann, R. Andreesen, P. Hoffmann, M. Edinger 99. Toag-1 enables prediction of CMV mediated transplant tolerance abrogation W. Gong, M. Klöpfel, K. Vogt, S. Haase, A. Reutzel-Selke, H. Volk, A. Pascher, B. Sawitzki 107. Analysis of Toll-like receptor 7 and Toll-like receptor 9 chimeric molecules J. Willemsen, P. Yu, S. Bauer 115. 12/15-lipoxygenase is involved in the limitation of inflammation and tissue damage in murine arthritis G. Krönke, J. Katzenbeisser, S. Uderhardt, W. Baum, R. Axmann, J. Zwerina, G. Schett 84. Antigen -specific immunotherapy inhibited Th2 via GATA-3 and Th17 cells in an allergic asthma model. N. Zhivkova, R. Karwot, J. H. Maxeiner, P. Scholtes, K. Soo, S. Finotto 92. Long-term vaccination efficiency is independent of regulatory T cells G. Gasteiger, W. Kastenmuller, L. Stross, D. H. Busch, T. Sparwasser, I. Drexler 100. Mutated CYLD affects the functional state of dendritic cells M. Bros, N. Wiechmann, V. Besche, N. Hövelmeyer, S. Reissig, S. Grabbe, A. Waisman, A. B. Reske-Kunz 108. The divergent role of the mammalian target of rapamycin (mTOR) in dendritic cells subtypes M. Haidinger, T. Weichhart, M. Poglitsch, M. Hecking, M. Zeyda, R. Geyeregger, J. Werzowa, W. H. Hörl, M. D. Säemann 116. Promoter methylation status is changed with altered DEFB1 gene expression in COPD E. Andresen, J. Bullwinkel, C. Lange, H. Heine 85. Selective depletion of Foxp3+ cells in DEREG mice allows functional analysis of regulatory T cells during experimental allergic airway inflammation A. Hartl, K. Lahl, H. Hamad, A. Ö. Yildirim, H. Fehrenbach, R. Teich, H. Garn, H. Renz, B. Lambrecht, T. Sparwasser 93. Retrovirally transduced, antigen-specific T cells for therapy of type 1 diabetes N. Mpofu, N. Saal, M. Hardtke-Wolenski, M. P. Manns, E. Jaeckel 101. Enhanced nuclear export of NFATc1 and impaired translocation of NFATc2 is observed in anergic iTreg generated by tolerogenic DC H. S. Adler, R. Orth, K. Streck, E. Graulich, K. Steinbrink 109. Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells F. Schmitz, A. Heit, S. Dreher, K. Tittel, J. Mages, T. Haas, A. Krug, K. Janssen, C. V. Kirschning, H. Wagner 117. Macrophage phosphoproteome dynamics after LPS-stimulation and its shaping by the MAPK-Phosphatase DUSP1: a SILAC-based approach G. Weintz, J. Olsen, J. Mages, M. Mann, R. Lang Scientific Programme – Friday, September 5, 2008 (continued) Time Lecture Hall 1 Lecture Hall 2 86. Molecular and functional analysis of the antigen receptor of Bet v 1-specific helper T lymphocytes A. Neunkirchner, V. M. Leb, K. G. Schmetterer, H. J. Kueng, D. Haiderer, S. Mutschlechner, B. Bohle, W. F. Pickl 94. BAC-transgenic mice for depletion of Foxp3+ regulatory T cells: Homeostatic expansion of Tregs J. Suffner, K. Hochweller, N. Garbi, G. Hämmerling 87. Cloning, expression and mapping of allergenic determinants of alphaS1-casein, a major cow’s milk allergen U. Schulmeister, H. Hochwallner, I. Swoboda, M. FockeTejkl, M. Nystrand, A. Harlin, J. Thalhamer, S. Scheiblhofer, W. Keller, B. Niggemann, S. Quirce, C. Ebner, A. Mari, G. Pauli, B. Geller, U. Herz, R. Valenta, S. Spitzauer 95. Lack of Foxp3 Treglinage marker expression in mouse epithelial cells C. T. Mayer, K. Lahl, C. Loddenkemper, T. D. Sparwasser Lecture Hall 3 17 Lecture Hall 4 Lecture Hall 5 102. Allogeneic disparities in the surface molecule immunoglobulin-like transcript 5 (ILT-5) induce potent antibody responses in stem cell transplanted patients K. Pfistershammer,, A. Lawitschka, J. Leitner, C. Klauser, R. Weigl, G. Böhmig, G. F. Fischer, M. Heemskerk, O. Majdic, W. F. Pickl, H. Greinix, P. Steinberger 110. Hsp60 modulates neutrophil functions A. Osterloh, M. Piedavent, F. Geisinger, B. Fleischer, N. Brattig, M. Breloer 118. Prophylactic blockade of TLR4 or therapeutic blockade of both TLR2 and TLR4 protects mice from Gram-negative infection and subsequent antibiotic therapy induced fatal septic shock C. J. Kirschning, G. Elson, R. Ferstl, S. Dreher, T. Müller, M. Freudenberg, B. Daubeuf, H. Wagner, S. Spiller 103. Dendritic cell-activated, endothelial cellspecific CTL recognizing a minor histocompatibility antigen rapidly induce transplant vasculopathy B. B. Bolinger, D. Engeler, P. Krebs, S. Miller, B. Ludewig, M. Hoffmann, P. Clavien, Y. Tian 111. Spatial separation of cross-presentation and endogenous antigen presentation S. Burgdorf, C. Schölz, A. Kautz, R. Tampé, C. Kurts 119. Biological characterization of mouse beta defensin 14 - an orthologue of human beta defensin 3 J. Röhrl, T. Hehlgans Time Lecture Hall 2 12.15 13.45 Satellite Lunch Symposium - Octapharma Immune modulation with intravenous immunoglobulin: the established and the advances Chair: S. Meuer Immunthrombocytopenia as the first model for biological treatment with IVIG in chronic inflammatory and autoimmune diseases P. Imbach Intravenous Immunoglobulins: mechanisms of action and options for improvement of therapeutic efficacy F. Nimmerjahn Basic research in human immunology creates new therapeutic options S. Meuer Discussion and wrap-up Time Lecture Hall 1 13.00 13.45 Drittmittelförderung der DFG: Kriterien für eine erfolgreiche Antragstellung Chair: Y. Samstag A. Strecker Scientific Programme – Friday, September 5, 2008 Time 14.00 15.30 Lecture Hall 1 Lecture Hall 2 Lecture Hall 3 Lecture Hall 4 18 Lecture Hall 5 Infection I Chair: F. Schmitz, S. Ehlers Allergy II Chair: B. Linhart, G. Stary Regulatory Lymphocytes II Chair: A. Rosenkranz, H. Schulze-Koops Mucosal Immunity Chair: R. Förster, M. Pasparakis B-Lymphocytes Chair: V. Sexl, T. Winkler 120. Restricted B cell receptor diversity converts acute into chronic viral infection A. Bergthaler, L. Flatz, A. Verschoor, A. N. Hegazy, E. Horvath, M. Holdener, K. Fink, B. Odermatt, D. D. Pinschewer 128. HLA-classII/peptide-TCR interactions of the single immunodominant T cell epitope of Art v 1, the major mugwort pollen allergen B. Jahn-Schmid, B. Maillere, V. Leb, W. Pickl, G. Gadermaier, F. Ferreira, B. Bohle 136. Generation of induced CD8+Foxp3+ regulatory T cells in vitro C. Mayer, K. Lahl, D. Dittlein, V. Wenzel, O. Gassner, J. Stephani, C. Loddenkemper, T. Sparwasser 144. Role of the transcription factor PU.1 in human lamina propria macrophages F. A. Lasitschka, A. Heidtmann, T. Giese, G. Wabnitz, A. Schrödter, J. Winter, A. Ulrich, S. C. Meuer, J. Schröder-Braunstein 152. Swiprosin 1 - positive regulator of BCR induced calcium flux C. Kroczek, C. Lang, A. Avramidou, L. Nitschke, A. Elter, H. M. Jäck, D. Mielenz 121. Interleukin 18 is essential for protective immunity against M. tuberculosis. B. Schneider, D. Korbel, K. Hagens, M. Koch, S. H. Kaufmann, H. Mittruecker, U. E. Schaible 129. Proteomic analysis and mass-spectrometric identification of differentially regulated proteins in primary human keratinocytes by allergens S. Ohnesorge, L. Dietz, P. Pankert, M. Schnoelzer, H. Thierse 137. CD8+CD38+ T-cells: A competent regulatory T-cell population A. Bollinger, H. Fehrenbach, T. Bollinger, T. Bollinger, Z. Orinska, S. Bulfone-Paus 145. Role of eosinophils in TGF-beta expression in human intestine F. Ulmer, S. C. Bischoff, A. Lorentz 153. Engagement of CD83 on B cells augments IgG1 response in vivo B. Kretschmer, K. Lüthje, S. Schneider, B. Fleischer, M. Breloer 122. Wnt/Frizzled signaling in infectious diseases: Deciphering the role of FZD1 in mycobacterial infections N. Reiling, T. Endermann, S. Ehlers, J. Neumann 130. Immunosuppression and allergy in organ transplant recipients: evidence for insufficient control of allergen specific responses T. Eiwegger, S. Gruber, C. Geiger, E. Dehlink, T. Frischer, P. Jaksch, W. Klepetko, Z. Szépfalusi 138. Tolerogenic potential of lentivirally transduced murine DC overexpressing antiinflammatory molecules V. Besche, N. Wiechmann, S. Trojandt, S. Grabbe, A. B. Reske-Kunz, M. Bros 146. CD4+ Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells A. M. Westendorf, D. Fleissner, S. Jung, A. D. Gruber, W. Hansen, J. Buer 154. The analysis of intravital two-photon imaging of germinal centres implies a novel lymphocyte migration and affinity maturation model M. Meyer-Hermann, M. Figge 123. Cavity formation in tuberculosis is mediated by interleukin-4 receptor-alpha-dependent mechanisms L. Heitmann, T. Schreiber, T. Thye, A. N. McKenzie, A. Cutler, F. Brombacher, R. D. Horstmann, C. G. Meyer, S. Ehlers, C. Hoelscher 131. Long-term tolerance in IgE-mediated allergy through molecular hematopoietic chimerism in a murine model U. Baranyi, B. Linhart, N. Pilat, M. Gattringer, C. Klaus, E. Schwaiger, F. Muehlbacher, J. Iacomini, R. Valenta, T. Wekerle 139. IL-27 inhibits the development of regulatory T cells via STAT3 M. Huber, V. Steinwald, A. Guralnik, A. Brüstle, P. Kleemann, C. Rosenplänter, T. Decker, M. Lohoff 147. Split tolerance after oral vaccination of mice with recombinant Escherichia coli Nissle 1917 expressing fimbrial adhesin K88 K. A. Remer, M. Bartrow, H. Moll, T. A. Oelschläger 155. Proapoptotic BH3only proteins Bim and Puma are essential for apoptosis of germinal center-derived memory B cells and antibodyforming cells S. Fischer,, D. Tarlinton, A. Strasser 124. Immunological inhibition of gC1qR/p33, a receptor for C1q, decreases adherence of Staphylococcus aureus to microvascular endothelium S. Sethi, M. W. Laschke, J. Roller, L. von Mueller, E. Peerschke, B. Ghebrehiwet, I. Bajric, M. D. Menger, M. Herrmann 132. Generation of an IgE knock-in mouse and its use in systemic anaphylaxis in vivo P. Yu, W. Lübben, S. Bauer 140. Development of “would-be” regulatory T cells and defective control of Th2-cytokine production in natural scurfy mutant mice K. I. Lahl, C. T. Mayer, J. Huehn, C. Loddenkemper, G. Eberl, J. Buer, T. Sparwasser 148. The role of IL-23/IL17 in Toxoplasma gondii induced small intestinal immunopatology M. L. Munoz-Roldan, D. Struck, M. Heimesaat, C. Hoelscher, U. Mueller, Y. Iwakura, N. Ghilardi, O. Liesenfeld 156. Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma U. E. Höpken, I. Anagnostopoulos, M. Broemer, C. Scheidereit, K. Joehrens, M. Hübler, H. Stein, M. Lipp, B. Dörken, A. Rehm 125. The fibrin-derived peptide B 15-42 (FX06) for treatment of capillary leak M. Gröger, W. Pasteiner, G. Ignatyev, U. Matt, S. Knapp, P. Friedl, D. Zinkl, K. Zacharowski, R. Hofer-Warbinek, P. Petzelbauer, S. Reingruber 133. Murine plasma and non-plasma B cells express different IgE repertoires T. Rogosch, S. Kerzel, L. Sikula, R. Maier, M. Zemlin 141. TLR2 ligands act directly on Treg to abrogate suppression of CD4+CD25- T cells H. Oberg, M. Juricke, S. Ussat, H. Ly, D. Kabelitz, D. Wesch 149. The mesenteric lymph node regulates the amplitude of IgA secretion in the drained area: potential role of the spleen in the immune response against orally applied cholera toxin A. Hahn, N. Thiessen, R. Pabst, M. Ahrendt, U. Bode 157. The adapter protein SLy2 represents a newly identified regulator of cytoskeletal rearrangements M. L. von Holleben Scientific Programme – Friday, September 5, 2008 (continued) Time Lecture Hall 1 Lecture Hall 2 Lecture Hall 3 Lecture Hall 4 Lecture Hall 5 175. Immunopathological basis of lymphocytic choriomeningitis virusinduced chorioretinitis and keratitis M. Zinkernagel, P. Krebs, B. Bolinger, S. Miller, B. Ludewig 134. Induced ablation of mast cells in adult mice: Slow recovery of mast cell populations in the tissues. J. Scholten, A. Gerbaulet, B. Hiller, W. Muller, T. Krieg, T. Buch, A. Waisman, K. Hartmann, A. Roers 142. Influence of CD4+CD25+ regulatory T cells on the transendothelial migration of CD4+CD25- T cells T. Bedke, M. Kretz, K. Mahnke, A. H. Enk 150. The role of CXCR5 in antigen-independent development and antigen-dependent maturation of nose-associated lymphoid tissue (NALT) J. Krege, S. Seth, S. Hardtke, A. Marques Davalos-Misslitz, R. Förster 158. Antigen receptor tail clue of class-switched memory B cells N. Engels, C. Heemann, L. König, T. Tsubata, S. Griep, V. Schrader, J. Wienands 127. CD8 T cell-mediated immune responses against cross-presenting liver sinusoidal endothelial cells leads to hepatitis D. Stabenow, K. Gärtner, M. Svorcova, M. Odenthal, H. Dienes, U. Protzer, P. A. Knolle 135. Timothy grass pollen major allergen Phl p 1 - a protease? K. Röschmann, P. König, A. J. Ulmer, A. Petersen 143. Expansion of immune-suppressive V 9V 2 T cells as a novel regulatory mechanism of IL-12 secreting dendritic cells M. W. Traxlmayr, A. M. Dohnal, D. Wesch, D. Kabelitz, T. Felzmann 151. T cell-specific deletion of gp130 renders the highly susceptible Interleukin-10 deficient mouse mutant resistant to intestinal nematode infection N. Fasnacht, M. C. Greweling, M. Bollati-Fogolin,, A. Schippers,, W. Müller, 159. Role of basophils in immunological memory responses A. J. Denzel, U. Maus, M. Rodriguez Gomez, M. Niedermeier, Y. Talke, N. Göbel, M. Mack 15.30 16.30 Time 16.45 18.00 19 Coffee Break / Poster Viewing / Exhibition Lecture Hall 1 Parallel Symposium 2: Infection Chair: S. Knapp, I. Förster Lecture Hall 2 Parallel Symposium 2: Adaptive Immunity: Regulation Chair: H. Stockinger, L. Klein Lecture Hall 3 Parallel Symposium 2: Adaptive Immunity: B-Cells Chair: G. Zlabinger, H-M. Jäck Origin of CD8+ effector and memory T cell Innate and adaptive IL-17 in the control of subsets immune responses D.H. Busch B. Stockinger Transcriptional control of B cell development M. Busslinger Mutual host pathogen reactions in tuberculosis U. Schaible Memory B cell sub-populations J.C. Weill Autoregulatory circuits in inflammatory T cell responses A. Scheffold Innate immune response to pneumococcal Innate Immunity in regulation of antibody pneumonia mediated inflammation S. Knapp R.E. Schmidt Time Lecture Hall 2 18.00 19.30 General Assembly DGfI Chair: S. Meuer 19.30 Departure with buses to the Viennese “Heuriger” Fuhrgassl-Huber Plasma cell memory A. Radbruch Scientific Programme – Saturday, September 6, 2008 Time 08.45 10.00 Lecture Hall 1 Lecture Hall 2 20 Lecture Hall 3 Parallel Symposium 1: Autoimmunity Chair: J. Smolen, H. Schulze-Koops Parallel Symposium 1: Inflammation Chair: J. Stöckl, K. Pfeffer Parallel Symposium 1: Allergy Chair: R. Valenta, J. Kalden The life history of an autoimmune driver clone E. Sercarz Mechanisms of inflammatory bone destruction K. Redlich Human Th17 cells S. Romagnani Immunopathogenesis of rheumatoid arthri- Novel cytokines in inflammatory diseases tis: induction of arthritogenic autoimmune F. Liew reactions by proinflammatory stimuli G. Steiner New facets in mast cell activation S. Bulfone-Paus Modeling multiple sclerosis: autoimmune T and B cells in the pathogenesis of the brain inflammatory disease H. Wekerle From allergens to vaccines R. Valenta 10.00 10.30 IL-17 and kynurenines in pathogenic inflammation L. Romani Coffee Break / Exhibition Your Power for Health Moderne Antikörper-Analyse Immunologische Produkte von Greiner Bio-One Gleichbleibende und reproduzierbare Bindung von Proteinen Geeignet für Transmissions-, Fluoreszenzund Lumineszenzmessungen Konstante, einheitliche Bindungseigenschaften Vielfältiges Spektrum an Microplatten und Streifen-Platten Kompatibel mit automatisierten Systemen Greiner Bio-One GmbH | Bad Haller Straße 32 | A-4550 Kremsmünster | Phone: (+43) 75 83 67 91-0 | Fax: (+43) 75 83 63 18 | E-Mail: offi[email protected] www.gbo.com/preanalytics Scientific Programme – Saturday, September 6, 2008 Time 10.30 12.15 Lecture Hall 2 Lecture Hall 3 Lecture Hall 4 21 Lecture Hall 5 Autoimmunity II Chair: R. Schwinzer, G. Staffler Infection II Chair: V. Leksa, O. Sharif Complement System Chair: M. Kirschfink, M. Wahrmann Cytokines, Chemokines & their receptors Chair: U. Höpken, M. Sibilia 160. CCR7 is essential for regulatory T cell function in antiGBM glomerulonephritis K. Hochegger, A. Rosenkranz, A. Rot 168. Immunemodulation by Siglec-E during Trypanosoma cruzi infection H. Erdmann, P. R. Crocker, B. Fleischer, T. Jacobs 176. Human factor H-related protein 4 (CFHR4) recruits Creactive protein to the surface of necrotic cells M. Mihlan, M. Hebecker, M. Huber-Lang, R. Dahse, P. F. Zipfel, M. Józsi 183. gp130 on macrophages/neutrophils negatively regulates Th17 development during experimental tuberculosis J. Sodenkamp, I. Foerster, W. Mueller, C. Hoelscher 161. The nuclear receptor PPARgamma serves as an intrinsic regulator of Th17 cell differentiation L. Klotz,, I. Dani, S. Burgdorf, A. Waisman, G. Eberl, J. Alferink, B. Langhans, T. Klockgether, P. Knolle 169. A novel Leishmania major amastigote culture system U. A. Wenzel, S. Möller, M. Klinger, S. Liebau, T. Laskay, G. van Zandbergen 177. Regulation of mouse ficolin-B expression in immune competent cells V. L. Runza, J. Kürchner, D. Weber-Steffens, D. N. Männel 184. The role of optineurin (FIP2) in adenovirus E3-14.7Kmediated inhibition of TNFR1 apoptosis L. Klingseisen, G. Knoll, W. Schneider-Brachert 162. Spontaneous CD8+ T Cell Mediated Liver Inflammation in a Transgenic Mouse Model of Autoimmune Hepatitis M. Zierden, E. Kühnen, M. Odenthal, H. P. Dienes 170. The elimination of Anaplasma phagocytophilum in vivo requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms K. Birkner, Y. Kern, B. Steiner, C. Bogdan, F. D. von Loewenich 178. Functional analyses indicate pathogenic role of factor H autoantibodies in atypical hemolytic uremic syndrome S. Strobel, P. F. Hoyer, C. J. Mache, E. Sulyok, P. F. Zipfel, M. Józsi 185. Overlapping functions of IL-7 and TSLP in lymphoid development D. Finke, L. Flueck, A. G. Farr, A. G. Rolink, S. Chappaz 163. Peripheral T cells are the therapeutic targets of highdose glucocorticoids in experimental autoimmune encephalomyelitis S. Wüst, J. van den Brandt, J. P. Tuckermann, R. Gold, H. M. Reichardt, F. Lühder 171. Oxidized phospholipids inhibit phagocytosis via a PKA dependent mechanism U. Matt, O. Sharif, T. Furtner, K. Stich, A. Zivkovic, S. Knapp 179. A dual role of the C5a receptor (C5aR) in acute and chronic dextran sulphate induced models of inflammatory bowel disease K. Johswich, M. Martin, A. Bleich, M. Kracht, O. Dittrich-Breiholz, E. Gessner, S. Suerbaum, C. Rheinheimer, A. Klos 186. Organ-specific suppression of CCL17 production through InterferonT. Globisch, S. Stutte, V. Lukacs-Kornek, C. Kurts, I. Förster 164. The proteasome inhibitor bortezomib depletes plasma cells and protects lupus mice from nephritis K. Neubert, S. Meister, K. Moser, F. Weisel, D. Maseda, K. Amann, T. H. Winkler, J. R. Kalden, R. E. Voll 172. Control of Persistent HBV Infection by Hepatitis B Core Antigen-activated NK cells: A Possible Mechanism for the HBV Persistence L. Huang, P. Chen, P. Knolle 180. Candida albicans CaHGT1 and its role in complement inhibition and modulation of other virulence factors I. Lesiak, G. Vogl, T. Schwarzmüller, M. P. Dierich, K. Kuchler, R. Würzner 187. Down-regulation of IFNduring HPV-induced carcinogenesis B. Rincon-Orozco, F. Rösl 165. CD8 T cells specific for a glomerular antigen induce renal inflammation in a CD4 help dependent fashion and may cause progressing Glomerulonephritis F. Heymann, E. E. HamiltonWilliams, I. Ludwig-Portugall, S. Quaggin, J. Flöge, H. Gröne, C. Kurts 173. Acute infection with a single hepatitis C virus strain in dialysis patients: analysis of adaptive immune response and its impact on viral sequence evolution L. Weseslindtner, C. Neumann-Haefelin, S. Viazov, A. Haberstroh, J. Kletzmayr, J. H. Aberle, J. Timm, S. R. Ross, R. Klauser-Braun, T. F. Baumert, M. Roggendorf, R. Thimme, H. Holzmann P419. Characterization of factor H binding to neutrophil granulocytes J. Losse, P.F. Zipfel, M. Józsi 188. An IFN reporter mouse model for the visualization of the initiation of the Type I interferon response in vivo P. Dresing, S. Scheu, R. M. Locksley 166. A new model for inflammatory bowel disease: A transgenic mouse expressing a crossreactive T cell receptor recognizing murine and bacterial HSP60 N. Schmidt, T. Joeris, U. Steinhoff 174. Type I Interferons as virulence-determining factors in Listeria monocytogenes infections B. Reutterer, S. Stockinger, A. Pilz, D. Soulat, R. Kastner, S. Westermayer, T. Rülicke, M. Müller, T. Decker 182. Rituximab-induced ADCC of tumour cells is variably modified by complement iC3b A. Dörr, C. Watzl, M. Kirschfink 189. Chemokine receptor CCR7 contributes to a rapid and efficient clearance of lytic MHV-68 from the lung while bronchusassociated lymphoid tissue harbors virus during latency J. R. Kocks, H. Adler, H. Danzer, K. Hoffmann, D. Jonigk, U. Lehmann, R. Förster 167. NAADP/Ca2+ signaling: a new therapeutic target for T cell mediated autoimmune disease F. Odoardi, C. Cordiglieri, W. Dammermann, B. Zhang, M. Hohenegger, B. V. Potter, A. Guse, A. Flügel 126. Yersinia enterocolitica differently affects DC subpopulations in vivo S. E. Autenrieth, T. Linzer, P. Warnke, S. Schmitz, I. B. Autenrieth 190. IL-27 acts as a Priming Signal on Human Keratinocytes and Antigen- Presenting Cells J. Zeitvogel, T. Werfel, M. Wittmann Immunity for Life Immunology for Health September 13 – 16, 2009 Berlin, Germany 2nd European Congress of Immunology www.eci-berlin2009.com Venue Congress President Congress Secretariat International Congress Center Berlin (ICC Berlin) Prof. Dr. med. Reinhold E. Schmidt K.I.T. GmbH Association & Conference Neue Kantstraße / Ecke Messedamm Medizinische Hochschule Hannover Management Group & Co. KG 14057 Berlin, Germany Klinik für Immunologie und Rheumatologie Kurfürstendamm 71 www.icc-berlin.de Carl-Neuberg-Straße 1 10709 Berlin, Germany 30625 Hannover, Germany Phone: +49 (0)30 – 246 03-0 Under the auspices of EFIS Phone: +49 (0)511– 532-6656 Fax: +49 (0)30 – 246 03-200 Fax: +49 (0)511– 532-9067 E-Mail: [email protected] E-Mail: [email protected] www.kit-group.org Scientific Programme – Saturday, September 6, 2008 Time Lecture Hall 1 10.30 12.45 Satellite Lunch Symposium - Phadia Vom rekombinanten Allergen zu neuen Allergietherapien Chair: R. Valenta, N. Reider Rekombinante Allergene: Vom Beginn zur Gegenwart H. Breiteneder Rekombinante Nahrungsmittelallergene K. Hoffmann-Sommergruber Klinische Anwendungen für rekombinante Allergene P. Schmid-Grendelmeier Klinische Erfahrungen mit Allergenchips J. M. Baron Die Komplexitaet von zellulären Allergietesten J. Kleine-Tebbe Immuntherapie und Verlaufkontrolle mit rekombinanten Allergenen G. Pauli 12.45 13.00 Pause (mit Snack) Time Lecture Hall 1 13.00 13.45 Klinische Fälle aus der Allergologie: Wie hätten Sie entschieden? Chair: Z. Szepfalusi, G. Pauli Werner Aberer, Reinhart Jarisch, Felix Wantke und Stefan Wöhrl präsentieren klinische Fälle aus der Allergologie 14.00 14.30 Best Poster Awards Chair: J. Smolen, S. Meuer Time Lecture Hall 2 15.00 General Assembly ÖGAI Chair: J. Smolen, M. Säemann 23 Warum soll ich in die Ferne schweifen, wenn mir ein Diagnostikunternehmen alles bietet, was ich brauche? Siemens Healthcare Diagnostics. Das Engagement, um Ihren individuellen Bedürfnissen auf den Grund zu gehen. Oberste Priorität hat für Sie eine optimale Patientenbetreuung, und für uns, Ihnen dabei zu helfen, dieses Ziel zu erreichen. Dazu bietet Ihnen Siemens ein beachtliches Portfolio leistungsorientierter Systeme, ein umfangreiches Testmenü sowie innovative IT- und Servicelösungen an. Sprechen Sie mit unserem Expertenteam über Ihre Vorstellungen – gemeinsam finden wir die optimale Lösung für Sie. Treten Sie näher: www.siemens.com/customer-first Answers for life. A91DX-0701169-A1-0000 © 2008 Siemens Healthcare Diagnostics Inc. All rights reserved. Poster Viewing 25 Thursday, September 4, 2008 Friday, September 5, 2008 09.30 – 10.30 hrs 09.30 – 10.30 hrs T-Lymphocytes I Chair: B. Jahn-Schmid, C. Scheinecker P001 – P028 Alloimmunity & Tolerance Chair: G. Böhmig, M. Säemann P209 - P233 T-Lymphocytes II Chair: W. Pickl, H. Stockinger P029 – P056 Allergy Chair: B. Bohle, S. Bulfone-Paus P234 - P264 Innate Immunity: Antigen-Presenting Cells Chair: T. Weichhart, M. Gilliet P057 - P075 Infection Chair: U. Schaible, S. Knapp P265 - P296 Signal Transduction Chair: L.J. Berg, W. Ellmeier P076 - P094 Mucosal Immunity Chair: S. Meuer, P. Brandtzaeg P297 - P308 Tumor Immunology Chair: O.J. Finn, T. Blankenstein P095 - P117 Friday, September 5, 2008 15.30 – 16.30 hrs Thursday, September 4, 2008 15.30 – 16.30 hrs Autoimmunity I Chair: R. Germain, E. Sercarz P309 - P329 Innate Immunity: Regulation Chair: M. Zeyda, S. Beissert P118 - P134 Autoimmunity II Chair: G. Steiner, J. Kalden P330 - P352 Pattern Recognition Receptors & Myeloid Cells Chair: F. Schmitz, J. Stöckl P135 - P151 Complement System and B-Lymphocytes Chair: F. Melchers, A. Radbruch P420 and P353 - P360 NK Cells Chair: C. Watzl, V. Sexl P152 - P164 Regulatory Lymphocytes Chair: L. Klein, R. Bacchetta P361 - P383 Vaccines & Adjuvants Chair: H. Lassmann, T. Weichhart P165 - P187 Cytokines, Chemokines & their receptors Chair: F.Y. Liew, L. Romani P384 - P404 Immunomodulation Chair: M. Fischer, G. Zlabinger P188 - P208 Veterinary Immunology Chair: B. Kaspers, A. Saalmüller P405 - P418 Business Meetings 26 As per date of printing Closed Business Meetings Wednesday, September 3, 2008 10.00 – 12.00 hrs Steering Committee Meeting ECI 2009 12.00 – 14.30 hrs Vorstandssitzung DGfI Lecture Room 25 / Level 8 Hotel Regina – Salon Makart Thursday, September 4, 2008 11.00 – 13.00 hrs Promotion Committee Meeting des ECI 2009 12.30 – 14.00 hrs Sitzung der DGfI Kommission “Fachimmunologe” Lecture Room 25 / Level 8 Lecture Room 13 / Level 7 Friday, September 5, 2008 12.00 – 14.00 hrs Arbeitskreise der DGfI Lecture Room 25 / Level 8 Saturday, September 6, 2008 09.00 – 11.00 hrs DGfI Educational Committee Lecture Room 25 / Level 8 Satellite Lunch Symposia Thursday, September 4, 2008, 12.15 – 13.45 hrs, Lecture Hall 1 B cell: Promising target in autoimmune diseases Chair: J. Smolen The biology of the B cell in autoimmune diseases A. Radbruch Clinical experiences with B cell therapies T. Dörner Safety: Experiences with Rituximab H-P. Brezinsek Friday, September 5, 2008, 12.15 – 13.45 hrs, Lecture Hall 2 Immune modulation with intravenous immunoglobulin: the established and the advances Chair: S. Meuer Introduction S. Meuer Immunthrombocytopenia as the first model for biological treatment with IVIG in chronic inflammatory and autoimmune diseases P. Imbach Intravenous Immunoglobulins: mechanisms of action and options for improvement of therapeutic efficacy F. Nimmerjahn Basic research in human immunology creates new therapeutic options S. Meuer Discussion and wrap-up Saturday, September 6, 2008, 10.30 – 12.45 hrs, Lecture Hall 1 Vom rekombinanten Allergen zu neuen Allergietherapien Chairs: R. Valenta, N. Reider Rekombinante Allergene: Vom Beginn zur Gegenwart H. Breiteneder Rekombinante Nahrungsmittelallergene K. Hoffmann-Sommergruber Klinische Anwendungen für rekombinante Allergene P. Schmid-Grendelmeier Klinische Erfahrungen mit Allergenchips J.M. Baron Die Komplexitaet von zellulaeren Allergietesten J. Kleine-Tebbe Immuntherapie und Verlaufkontrolle mit rekombinanten Allergenen G. Pauli 12.45 - 13.00 Pause (mit Snack) 13.00 - 13.45 Klinische Fälle aus der Allergologie: „Wie hätten Sie entschieden” 27 Information on Posters 28 Poster Topics P01 T-Lymphocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P02 Innate Immunity: Antigen-Presenting Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P03 Signal Transduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P04 Tumor Immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P05 Innate Immunity: Regulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P06 Pattern Recognition Receptors & Myeloid Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P07 NK cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P08 Vaccines & Adjuvants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P09 Immunomodulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P10 Alloimmunity & Tolerance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P11 Allergy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P12 Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P13 Mucosal Immunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P14 Autoimmunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P15 B-Lymphocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P16 Regulatory Lymphocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P17 Cytokines, Chemokines & their receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P18 Veterinary Immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P19 Complement system . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P001 – P056 P057 – P075 P076 – P094 P095 – P117 P118 – P134 P135 – P151 P152 – P164 P165 – P187 P188 – P208 P209 – P233 P234 – P264 P265 – P296 P297 – P308 P309 – P352 P353 – P360 P361 – P383 P384 – P404 P405 – P418 P420 – P420 • Posters will be on display from Wednesday, September 3, (15.00 hrs) to Saturday, September 6, 2008, (15.00 hrs). • Poster mounting will be possible on: Wednesday, September 3, 2008 from 10:00 - 15:00. • Removal will be possible on: Saturday, September 6, 2008 from 14:30 - 15:30. Please note that posters not removed by then, will be taken down by conference staff and will not be stored or forwarded to the authors after the meeting. • You will find your poster board number in the author index at the end of the abstract book. Presence at Posters In order to enable discussion and interaction with other participants, we request you or another member of your group to be at your poster board at the following times: • Thursday, September 4, 2008, 09.30 – 10.30 hrs T-Lymphocytes-1 P001 - P028 T-Lymphocytes-2 P029 - P056 Innate Immunity: Antigen-Presenting Cells P057 - P075 Signal Transduction P076 - P094 Tumor Immunology P095 - P117 • • • Thursday, September 4, 2008, 15.30 – 16.30 hrs Innate Immunity: Regulation Pattern Recognition Receptors & Myeloid Cells NK Cells Vaccines & Adjuvants Immunomodulation P118 - P134 P135 - P151 P152 - P164 P165 - P187 P188 - P208 Friday, September 5, 2008, 09.30 – 10.30 hrs Alloimmunity & Tolerance Allergy Infection Mucosal Immunity P209 - P233 P234 - P264 P265 - P296 P297 - P308 Friday, September 5, 2008 15.30 – 16.30 hrs Autoimmunity-1 Autoimmunity-2 B-Lymphocytes Regulatory Lymphocytes Cytokines, Chemokines & their receptors Veterinary Immunology Complement System P309 - P329 P330 - P352 P353 - P360 P361 - P383 P384 - P404 P405 - P418 P420 If this is not possible, please leave a note on your poster board detailing the times when you will be present at the board. Information for Speakers 29 Projection and Technical Setting • All rooms will be equipped with data- and overhead projection (no slides). • It is essential that you load and view your presentation in the slide preview room preferably in the morning of the day your talk is scheduled, but no later than 2 hours in advance. • The lecture rooms are exclusively equipped with Windows-PCs (no Macintosh machines). In case you absolutely need to use your own laptop or notebook, please contact the preview center well in advance of your talk. • Please bring a USB-stick or CD-ROM, all formatted for Windows® (PC). You may want to carry a second disk/CD as a back-up in case there is any unsolvable technical problem. • File Format: Microsoft® Power Point™ presentation formatted for Windows® (PC) only. (Operating system: Windows XP®) • Preferred Resolution: XGA (1024 x 768 pixel) Preview Room The Speaker’s Preview will be located in Room Nr. 11 on Level 7. Equipment for a final check of the sequence of your presentation is available in the preview room. All presenters should bring their electronic presentation to the preview room preferably in the morning of the day of the talk, but no later than 2 hours before the start of the session. For sessions starting at 08.15 hrs, the PowerPoint presentations should be handed in the previous day. Opening hours of the preview room: Wednesday, September 3, 2008 12.00 – 18.00 Thursday, September 4, 2008 07.30 – 18.00 Friday, September 5, 2008 07.30 – 18.00 Saturday, September 6, 2008 08.15 – 15.00 Programme Changes The organisers cannot assume any liability for changes in the programme due to external or unforeseen circumstances. Congress Information 30 Abstract Books You will find an Abstract Book in your conference bag. Accreditation The Joint Annual Meeting of Immunology has applied for credits at the European Accreditation Council for Continuing Medical Education, Institution of the UEMS. The number of credits (which will be announced after the meeting) will figure on the respective confirmation, which will also be sent after the meeting. The rules of the EACCME state that participants are kindly asked to fill in the feedback (evaluation) form included in the conference bag. It can be returned to the registration desk. Participants applying for EACCME Credits will have to have their badge scanned daily at the registration desk before entering the conference. The confirmation will be mailed after the conference at the end of September. Die österreichische Akademie der Ärzte hat an diese Veranstaltung 41 Diplomfortbildungspunkte vergeben. Admission to Lecture Halls Participants are requested to enter the lecture halls via Level 8 only. Badges Participants will receive their name badges from the conference registration desk. Since only registered participants will be permitted to attend scientific sessions, the exhibition and poster areas, you are kindly asked to wear your badge when entering the congress venue. Please note that admission to scientific sessions is strictly restricted to participants wearing their badges. Exhibitors and accompanying persons are not entitled to attend the scientific sessions. Lost badges can be replaced at the registration desk. However, a handling fee of € 20,- will be charged. The following badge-colours are used at the Congress: White Yellow Green Red Participants Accompanying Persons Exhibitors Staff Cancellations and Refunds Notice of cancellation must be made in writing by registered letter or fax to the Congress Office. The policy for refunding registration fees is as follows: Written cancellation received: - before July 31, 2008: 75% refund - after July 31, 2008: no refund The date of the postmark or fax ID is the basis for considering refunds. Refunds will be made after the congress. Cash Bar Snacks and drinks may be purchased at the cash bar on Level 8 during congress hours. Certificate of Attendance Confirmations of attendance will be issued at the registration desk. City Tour The city tour “Classical Vienna – A City Stroll” will take place on Thursday, September 4, 2008. It is free of charge for accompanying persons, however, registration in advance is mandatory. Coffee Breaks During the session breaks, refreshments will be served free of charge to participants wearing name badges. Exhibition Opening Hours Wednesday, September 3, 2008 Thursday, September 4, 2008 Friday, September 5, 2008 Saturday, September 6, 2008 15.00 – 17.00 hrs 08.15 – 17.00 hrs 08.15 – 17.00 hrs 08.45 – 15.00 hrs Hotel and Tours Desk Mondial, the official travel agency of the meeting, will be present at the conference on Wednesday, September 3, 2008 from 14.30 – 17.30 hrs and on Thursday, September 4, 2008 from 07.30 – 09.30 hrs. If you have any questions regarding your hotel booking or the city tour, please approach Mondial. They will be located near the registration desk. Internet A few internet stations will be available at the conference. Please ask at the registration desk. You may also find small internet cafés throughout the city. Congress Information 31 Message Board A Message Board and notice of the daily programme are available on Level 7 and Level 8. Poster Mounting and Removal There are four poster sessions: Thursday and Friday from 09.30 – 10.30 hrs and from 15.30 – 16.30 hrs. Poster mounting will be possible on Wednesday, September 3, 2008 from 10.00 – 15.00 hrs. Poster removal will be possible on Saturday, September 6, 2008 from 14.30 – 15.30 hrs. Please note that the organisers cannot assume any liability for loss or damage of posters displayed in the poster area. Posters that are not removed by 15.30 hrs on Saturday, September 6, 2008 will be removed by staff and will not be stored or forwarded to the author after the meeting. Preview Room The Speaker’s Preview will be located in Room Nr. 11 on Level 7. Equipment for a final check of the sequence of your presentation is available in the preview room. All presenters should bring their electronic presentation to the preview room preferably in the morning of the day of the talk, but not later than 2 hours before the start of the session. For sessions starting at 08.15 hrs, the PowerPoint presentations should be handed in the previous day. Following are the opening hours of the preview room: Wednesday, September 3, 2008 12.00 – 18.00 Thursday, September 4, 2008 07.30 – 18.00 Friday, September 5, 2008 07.30 – 18.00 Saturday, September 6, 2008 08.15 – 15.00 Public Transport Registered congress participants receive a 4-days-ticket when picking up their registration materials. This ticket is valid for all public transport within Vienna from Wednesday, September 3, 2008 to Saturday, September 6, 2008. This ticket is not valid for going to the airport, since the airport is out of town. Congress participants are kindly requested to return their ticket if it is not needed. Registration Desk opening hours Wednesday, September 3, 2008 Thursday, September 4, 2008 Friday, September 5, 2008 Saturday, September 6, 2008 10.00 – 18.00 07.30 – 18.00 07.30 – 18.00 08.15 – 15.00 Smoking Policy The Joint Annual Meeting of Immunology is a “No-smoking-Conference”. Please note that smoking is banned from all public buildings. Restaurants and bars may, depending on size, be declared either as “smoking” or “no-smoking” locations or have separate areas and ventilation systems. Staff Should you have any questions, congress staff, recognizable by a blue t-shirt and red badge, will be pleased to help you. Registration Fees 32 Onsite registration Wednesday, September 3, 2008 Thursday, September 4, 2008 Friday, September 5, 2008 Saturday, September 6, 2008 10.00 – 18.00 07.30 – 18.00 07.30 – 18.00 08.15 – 15.00 Payment received before June 15, 2008 after June 15, 2008 and on-site Members EUR 190.— EUR 300.— Student Members* EUR 95.— EUR 135.— Non-Members EUR 280.— EUR 390.— Student Non-Members* EUR 140.— EUR 180.— Accompanying Persons EUR 60.— EUR 60.— Day Ticktet Member EUR 140,— Day Ticket Non-Member EUR 180,— * please provide a copy of an ID together with your registration What is covered by the registration fee? Participants • • • • • • • Admission to all scientific sessions Access to the exhibition Coffee breaks Welcome reception at the City Hall Thursday, September 4, 2008, 19.00 hrs Abstract book Programme 4-days public transport ticket Accompanying persons • • • Admission to the welcome reception at the City Hall Thursday, September 4, 2008, 19.00 hrs Classical Vienna City Tour*, Thursday, September 4, 2008, 09.00 hrs Access to the exhibition and coffee breaks (no admission to lectures) *Please note that the classical city tour is not available for on site registrations of accompanying persons. Payment of registration fees may be made in cash (Euros only), by maestro debit card, or by the following credit cards: Diners Club, Mastercard, Visa. Please note that the reduced registration fee is only applicable if it has been credited to the congress account before the deadline. Registering without performing an actual payment is not sufficient to benefit from the reduction. Pre-registration without payment of the registration fee is possible. The full fee is to be paid at the registration desk. Cancellations and refunds: Notice of cancellation must be made in writing by registered letter or fax to the Congress Office. Notice of cancellation must be made in writing by registered letter or fax to the Congress Office. The policy for refunding registration fees is as follows: Written cancellation received: - before July 31, 2008: 75% refund - after July 31, 2008: no refund The date of the postmark or fax ID is the basis for considering refunds. Refunds will be made after the congress. General Information 33 Bank services - Money matters Banks are open from 8.30 – 12:30 and from 13:30 – 15:00, Monday to Friday. Some banks are also open on Thursday afternoons until 17:30 hrs. Cash machines (ATMs), which accept all major international bank cards, are available throughout the city. There is a cash machine in the main entrance of the Vienna General Hospital. The currency of Austria is the Euro (€). Major credit cards are widely accepted, but please always check beforehand. Car Parking The Vienna General Hospital has approximately 800 car parking spaces available for visitors in an underground car park. The entrance is at Währinger Gürtel. Eating out in Vienna Vienna has a broad variety of local and international restaurants, many of them located in the old city and in the vicinity of the conference venue. Emergency services The phone number to dial for emergencies is 112. GSM cell phone roaming GSM cell/mobile phone roaming is available without any problems for all major international providers. It is advisable to inquire beforehand at your provider which roaming company in Austria offers the cheapest tariffs. Insurance In registering for the Joint Annual Meeting of Immunology 2008 participants agree that neither the organising committee nor the congress office assume any liability whatsoever. Participants are requested to make their own arrangements for health and travel insurance. Internet and printing facilities A few internet stations will be available at the conference. Please ask at the registration desk. You may also find small internet cafés throughout the city. Language The official language of the congress will be English (no simultaneous translation). Medical care The Austrian National Health Service may be used by all persons from European Union countries who have the E111 Form (EHICard). This form/card should be obtained at the health service or post office of the visitor’s home country before travelling to Austria. It is advisable for participants from countries outside the European Union to take out medical insurance before reaching Austria, since they will be charged for access to the national health system. Pharmacies Medicines that do not require a medical prescription may be purchased over the counter. If you need advice, do not hesitate to ask the pharmacist. If you usually take medication, it is advisable to bring a sufficient amount with you for your trip. Pharmacies in the vicinity of the conference venue are on Zimmermannplatz 1, 1090 Vienna. There are duty pharmacies open 24 hours a day. Outside each pharmacy there is a list of the nearest duty pharmacies, or you may ask at your hotel reception for more information. Safety - Crime Visitor safety is generally adequate. Like in any other major European city, you can walk everywhere using common sense. Pick pocketing in heavily visited tourist zones or in public transport lines might be a concern. Unfortunately experience has shown that some basic precautionary measures should always be kept in mind in any city: - Do not carry important items like flight tickets, passports etc. with you when visiting the conference or strolling through the city; leave them in the hotel safe during your stay. Rather carry a photocopy of your passport or an identity card with you. - Try not to carry all documents, money, credit cards and other essential items and valuables in one bag. If it gets lost or stolen, everything will be gone and might be difficult to replace on short notice, especially passports and visa to return to your country of residence. - Take off your name badge when leaving the conference centre. Shops Shops in Vienna are generally open between 09.00 and 18.00 hrs Mon-Fri, and between 09.00 and 12.00 on Saturdays. Some shops are open until 19.00 Mon-Fri and until 17.00 on Saturdays. Shops are usually closed on Sundays, except for a few establishments with special permits. Taxis There are Taxi ranks throughout the city, but calling is often your best option. Please address your hotel reception or the registration desk of the conference venue. A taxi station can be found in front of the main entrance at Level 5 and at Lazarettgasse (exit on Level 4). Tipping Tips are not obligatory in Austria, although people usually tip approximately 10% at restaurants, cafés and bars. Hotel and airport porters will accept tips, depending on the luggage. General Information 34 Travelling within Vienna Registered congress participants receive a 4-days-ticket when picking up their registration materials. This ticket is valid for all public transport within Vienna from Wednesday, September 3, 2008 to Saturday, September 6, 2008. This ticket is not valid for going to the airport, since it is out of town. Congress participants are kindly requested to return their ticket if it is not needed. For accompanying persons and exhibitors tickets are available from machines at underground stations (maestro debit cards accepted), at news agents’, or at Vienna Transport Authority’s ticket offices. Tickets bought in advance are cheaper and must be punched in a blue ticket cancelling machine on the tram or bus, or at the barrier before boarding the underground train. Single trip tickets can be used for any single trip within Vienna. You may change lines (and switch between bus, tram, underground, or urban train), but you may not interrupt your journey. Ticket price: EUR 1.70 when bought in advance; EUR 2.20 when bought in the means of transport. The 24-hour pass is valid throughout Vienna for exactly 24 hours from the time it is punched. Price: EUR 5.70 The 72-hour pass is valid throughout Vienna for exactly 72 hours from the time it is punched. Price: EUR 13.60 The 8-day ticket is valid for any eight days, not necessarily eight consecutive days. It is a rover ticket, which means you can travel all around Vienna. You can also use the ticket for several people travelling together. Simply punch one strip for each person in the group. Price: EUR 27.20 Week-pass valid from Monday to Monday, 09.00 hrs. Price: EUR 14.00 A taxi is the most comfortable way of getting around the city but also the most expensive. They are identifiable by their roof-sign which is lit when available. Prices must be displayed inside the cab and meters (which are compulsory in all cabs) will indicate the fare. Travelling from and to the Airport Vienna International Airport is located 13 kilometres south east of Vienna. City Airport Train (CAT) The train service between the airport and the city centre (City Air Terminal – Station ‘Wien Mitte’) is every 30 minutes and takes 16 minutes. It is covered from 6:05 hrs to 00:05 hrs (Airport to City) and from 5:38 hrs to 23:38 hrs (City to Airport). Tickets may be purchased online (EUR 8.00 single or EUR 15.00 return), from ticket machines at the airport/station (EUR 9.00 single or EUR 16.00 return) or on board (EUR 10.00 single). From ‘Wien Mitte’ you can take the green line (U4) direction Heiligenstadt and get off at ‘Spittelau’ (five stops) and then take the brown line (U6) direction Siebenhirten and get off at Michelbeuern-Allgemeines Krankenhaus. Taxi fares to the conference venue are about EUR 35.00 and take around 25 minutes. There is a taxi rank outside the airport terminal. Night-time fees are slightly higher. Travelling to the Vienna General Hospital by Public Transportation The Vienna General Hospital (the congress venue) is easily reachable by taking the subway line U6 (the brown line) and getting off at Michelbeuern – Allgemeines Krankenhaus. Furthermore, it can be reached by tramway 42, tramways 5 and 33 (stop Lazarettgasse) as well as tramways 43 and 44 (stop Alser Straße). Vienna Vienna, the capital of Austria, 2 million inhabitants, is situated on the banks of the Danube. Vienna is a dream city for anyone with an interest in history. Narrow, medieval alleyways and grand boulevards lead to historic sights such as the Imperial Palace (Hofburg), Belvedere Palace, Burgtheater, the Spanish Riding School, St. Stephen’s Cathedral, the Opera House, Karlskirche, or Schönbrunn Palace. Vienna has been synonymous with music for centuries, and was home to Mozart, Beethoven, Schubert and Johann Strauss. The Vienna Philharmonic Orchestra is one of the world’s top orchestras; the Vienna Boys’ Choir is triumphantly successful wherever it tours. Vienna possesses a lively and vast array of cultural attractions, from classical or experimental theatre, film or dance festivals, opera or operetta, to exhibitions and concerts. The Museum of Fine Arts is one of the world’s largest and most distinguished museums, housing priceless works of art. Art accompanies you wherever you go in Vienna - even some of its underground stations are listed properties on account of their elegant, ornamental Jugendstil (Art Nouveau) style designed by Otto Wagner. For more information about Vienna, please see www.aboutvienna.org. Venue 35 Location of the Vienna General Hospital and the Lecture Centre HÖRSAALZENTRUM EBENE 07/08 GENERAL INFORMATION Congress venue Vienna General Hospital Allgemeines Krankenhaus Wien Lecture Hall Centre Hörsaalzentrum Währinger Gürtel 18-20 A-1090 Vienna, Austria Public transportation in Vienna The Vienna General Hospital (the congress venue) is easily reachable by taking the subway line U6 and getting off at the station ”Michelbeuern – Allgemeines Krankenhaus”. Furthermore it can be reached with the tramway 42, the tramway 5 and 33 (station ”Lazarettgasse”) as well as the tramways 43 and 44 (station ”Alser Strasse”) Venue 36 Level 7 Access from main entrance No entrance to Lecture Halls. Please use the doors on Level 8. Escalators to main entrance Red Elevators Green Elevators to main entrance Lecture Hall 4 ? ? ? ? ? ? Exhibition Exhibition Lecture Hall 5 Lecture Hall 3 Lecture Hall 1 Exhibition Lecture Hall 2 ?? ?? Coffee ?? Registration Coffee Coffee Cloakroom Meeting Room 13 Preview Room Level 8 Access to Lecture Halls Entrance to Lecture Halls Escalators to main entrance Green Elevators to main entrance Red Elevators ?? ?? Posters ? ?? Lecture Hall 3 Posters Posters Lecture Hall 1 Lecture Hall 2 ?? Lecture Hall 5 ? ? ? Posters ? and ? Exhibition Posters ? ? Lecture Hall 4 Cash Bar ? Coffee Posters Meeting Room 25 Social Events 37 Thursday, September 4, 2008, 19.00 hrs Welcome Reception by the Mayor of Vienna at the Vienna City Hall The mayor of the city of Vienna is pleased to invite you to a Welcome Reception. Meet your colleagues at this event. Enjoy the evening with a Buffet and live music. Dress code: business attire Attendance is free for registered participants and accompanying persons. Those who have registered prior to the congress should have received their ticket with the congress material. Please remember to bring your ticket. Please note that attendance is limited and advance registration is mandatory in order to receive a ticket! A limited number of tickets will still be available for onsite bookings. Venue: Vienna City Hall, Lichtenfelsgasse 2, 1010 Vienna Directions: From the conference venue take the brown underground line U6 (direction Siebenhirten) one stop and get off at Alser Strasse. Take the tram 43 (direction Schottentor) and get off at Landesgerichtsstrasse. From there you can walk along Landesgerichtsstrasse until you reach the city hall on your left hand side. Walk past the city hall and turn left into Lichtenfelsgasse. The entrance to the reception is on your left. Alternatively you can take the brown underground line U6 (direction ‘Floridsdorf’) three stops and get off at ‘Spittelau’. Take the green underground line U4 (direction ‘Hütteldorf’) three stops and get off at ‘Schottenring’. Take the purple underground line U2 (direction ‘Karlsplatz’) two stops and get off at ‘Rathaus’. Take the exit towards the front of the train and turn left and cross the street. This is Lichtenfelsgasse. The entrance to the Reception is on the left hand side. Friday, September 5, 2008, 19.30 hrs. Dinner at a Viennese “Heuriger” An evening spent in typical Austrian wine taverns in Vienna. You will be served a delicious Austrian buffet and excellent local wines while enjoying the atmosphere of a traditionally decorated restaurant. “Heuriger” could be translated with “of this year” and means a young crisp wine produced during the current wine season. Only wine producers serving their own product, grown in the vineyards of Vienna, may call their tavern “Heuriger”. Dress code: casual Venue: Weingut Fuhrgassl Huber Neustift/Walde 68 1190 Vienna Buses depart from the main entrance on Level 5 of the Vienna General Hospital, at 19.30 hrs and return in the late evening. Price per ticket including transport, music, food and beverages: EUR 45.– Please note that advance registration is mandatory in order to receive a ticket! A limited number of tickets will still be available for onsite bookings. Underground Map 38 Congress venue Welcome Reception 9 City Map 39 ;TRcdaT2T]caT^UcWT EXT]]P6T]TaP[7^b_XcP[ " $ ! & ! ( # " ' % 1) Lecture Centre of the Vienna General Hospital (AKH) 2) City Hall (Welcome Reception) 3) Arcotel Boltzmann 4) Mercure Josefshof 5) Hotel & Palais Strudlhof 6) Carlton Opera 7) Wandl 8) Atlas 9) Academia 10) Pension Ani Falstaff 11) Pension Ani 12) Regina 13) Royal Exhibition – General Information 40 Exhibiton Organiser: Name Address MAW – Medizinische Ausstellungs- und Werbegesellschaft Freyung 6 1010 Vienna, Austria Telephone Ms. Ingrid Winkler: Ms. May-Britt Ernst: +43 1 535 6016 [email protected] Fax E-mail +43 664 441 8285 +43 664 105 2018 Exhibition Dates & Opening hours: Wednesday, September 3, 2008 Thursday, September 4, 2008 Friday, September 5, 2008 Saturday, September 6, 2008 15.00 – 17.00 hrs 08.15 – 17.00 hrs 08.15 – 17.00 hrs 08.45 – 15.00 hrs Poster Mounting, Poster Viewing, Poster Removal Hours Wednesday, September 3, 2008 – poster mounting Wednesday, September 3, 2008 – poster viewing Thursday, September 4, 2008 – poster viewing Friday, September 5, 2008 – poster viewing Saturday, September 6, 2008 – poster viewing Saturday, September 6, 2008 – poster removal 10.00 – 15.00 hrs 15.00 – 18.00 hrs 08.15 – 18.00 hrs 08.15 – 18.00 hrs 08.45 – 14.30 hrs 14.30 – 15.30 hrs Location Venue Exhibition Areas Address Lecture Centre of the Vienna General Hospital Level 7 and Level 8 Währinger Gürtel 18-20, 1090 Vienna, Austria List of Sponsors, Exhibitors and Advertisers* 41 Ärztezentrale Adressen- und Drucksortenverlag, Vienna, Austria Abd Serotec- Endeavour House, Oxon, United Kingdom Acris Antibodies, Hiddenhausen, Germany Active Motif Europe, Rixensart, Belgium Aesca Pharma, Traiskirchen, Austria Alk Abello Allergie – Service GmbH, Linz, Austria Allergopharma, Vienna, Austria AstraZeneca Österreich, Vienna, Austria Becton Dickinson Austria, Schwechat, Austria Bencard Allergie, Vienna, Austria Bender Medsystems, Vienna, Austria Biomedica, Vienna, Austria Bio-Rad Laboratories, Munich, Germany Biotest AG, Dreieich, Germany Biozym Biotech Trading, Vienna, Austria Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany CellGenix Technologie Transfer, Freiburg, Germany Cell Kinetice, Lod, Israel 2nd European Congress of Immunology – ECI 2009 eubio, Vienna, Austria Fermentas, St. Leon-Rot, Germany GE Healthcare Europe, Vienna, Austria Greiner Bio – One, Kremsmünster, Austria Hal Allergy, Vienna, Austria *(as per printing date) List of Sponsors, Exhibitors and Advertisers* 42 Invitrogen, Karlsruhe, Germany Jackson ImmunoResearch Europe Ltd., Suffolk, United Kingdom LaVision BioTec, Bielefeld, Germany Mabtech AB, Nacka Strand, Sweden Ferdinand Menzl Medizintechnik, Vienna, Austria Miltenyi Biotec, Bergisch Gladbach, Germany NatuTec, Frankfurt am Main, Germany New England Biolabs, Frankfurt am Main, Germany Novartis Pharma, Vienna, Austria Octapharma, Lachen, Switzerland Partec, Görlitz, Germany PeproTech, Hamburg, Germany Phadia Austria, Vienna, Austria Porsche Austria ProFas, Regensburg, Germany Charles River Consulting, Sulzfeld, Germany Roche Austria, Vienna, Austria R + D Systems, Wiesbaden, Germany Siemens Medical Solutions Diagnostics, Vienna, Austria Stallergenes France, Antony Cedex, France Stemcell Technologies, Grenoble, France tebu – bio, Offenbach, Germany THP Medical Products, Vienna, Austria Werfen Austria, Vienna, Austria Wiley Blackwell, Weinheim, Germany Yakult Deutschland, Neuss Germany *(as per printing date) Notes Printed in Austria by: ROBIDRUCK, 1200 Vienna – www.robidruck.co.at Das Immunglobulin in seiner natürlichen Form Natur weitergeben Zusammensetzung: 1 ml Intratect® enthält 50 mg Plasmaproteine vom Menschen, davon mind. 96 % IgG (57,2 % IgG1, 37,2 % IgG2, 3,1 % IgG3, 3,0 % IgG4). Höchstgehalt an IgA: 2 mg/ml. Hilfsstoffe: Glycin, Wasser zur Injektion. Anwendungsgebiete: Substitutionstherapie bei primären Immunmangelsyndromen, sekundärer Hypogammaglobulinämie und rezidivierenden bakteriellen Infektionen bei CLL und multiplem Myelom, Kinder mit angeborenem AIDS und rezidivierenden Infektionen. Immunmodulation bei ITP bei Kindern oder Erwachsenen mit einem hohen Blutungsrisiko oder vor chirurgischen Eingriffen zur Korrektur der Thrombozytenzahl, Guillain-Barré-Syndrom und Kawasaki-Syndrom. Allogene Knochenmarktransplantation. Art der Anwendung, Dosierung: Intratect® wird intravenös verabreicht. Dosierung und Intervalle der Infusionen richten sich nach der Indikation. Gegenanzeigen: Überempfindlichkeit gegen jegliche Bestandteile des Präparates. Überempfindlichkeit gegen homologe Immunglobuline, insbesondere in den sehr seltenen Fällen von IgA-Mangel, wenn der Patient Antikörper gegen IgA aufweist. Spezielle Hinweise: Bestimmte schwere unerwünschte Nebenwirkungen können im Zusammenhang mit der Infusionsgeschwindigkeit stehen. Es ist die in der Gebrauchsinformation beschriebene Infusionsgeschwindigkeit zu beachten. Die Patienten müssen während der gesamten Dauer der Infusion kontrolliert und auf Symptome unerwünschter Wirkungen beobachtet werden. Bestimmte unerwünschte Nebenwirkungen können bei einer hohen Infusionsgeschwindigkeit häufiger auftreten, bei Patienten mit Hypo- oder Agammaglobulinämie mit oder ohne IgA-Mangel, bei Patienten, die zum ersten Mal Immunglobulin vom Menschen erhalten oder, in seltenen Fällen, bei einem Wechsel des Immunglobulin-Präparates oder nach einer längeren Behandlungspause. Nebenwirkungen: Gelegentlich können Schüttelfrost, Kopfschmerzen, Fieber, Übelkeit und Erbrechen, allergische Reaktionen, niedriger Blutdruck, Gelenkschmerzen und leichte Rückenschmerzen. Selten: plötzlicher Blutdruckabfall, vorrübergehende Hautreaktionen, Anstieg des Serumkreatinin-Spiegels, akutes Nierenversagen, thromboembolische Komplikationen. In Einzelfällen: anaphylaktischer Schock, reversible aseptische Meningitis, reversible hämolytische Anämie/Hämolyse. Wechselwirkungen: Die Gabe von Immunglobulin kann für eine Dauer von mindestens 6 Wochen und bis zu 3 Monaten die Wirksamkeit von attenuierten Lebendimpfstoffen wie Masern-, Röteln-, Mumps- und Windpockenimpfstoffen beeinträchtigen. Nach der Gabe dieses Präparates ist vor der Impfung mit attenuierten Lebendimpfstoffen eine Wartezeit von 3 Monaten einzuhalten. Bei Masernimpfung kann diese Beeinträchtigung bis zu einem Jahr fortbestehen. Daher sollte bei Patienten, die Masernimpfstoff erhalten, der Antikörperstatus überprüft werden. Handelsformen: Gebrauchsfertige Lösung zur intravenösen Infusion in Durchstichflaschen aus Glas zu 20 ml (1,0 g), 50 ml (2,5 g), 100 ml (5,0 g) und 200 ml (10,0 g). Biotest Pharma GmbH · Postfach 10 20 40 · D-63266 Dreieich · www.biotest.de Intratect_DGN.260706.indd 1 01.08.2006 11:41:20 Uhr