1 List of Publications, Georg Feldmann MD (07/2014) Original

1 List of Publications, Georg Feldmann MD (07/2014) Original

List of Publications, Georg Feldmann MD
(07/2014)
Original articles, first- and last-authorships:
Schütte U, Bisht S, Heukamp LC, Kebschull M, Florin A, Haarmann J, Hoffmann P, Bendas G, Buettner R,
Brossart P, Feldmann G.
Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell
carcinoma.
Transl Oncol. 2014 Apr;7(2):309-21. doi: 10.1016/j.tranon.2014.02.005. Epub 2014 Mar 4.
Fendrich V, Oh E, Bang S, Karikari C, Ottenhof N, Bisht S, Lauth M, Brossart P, Katsanis N, Maitra A,
Feldmann G.
Ectopic overexpression of sonic hedgehog (Shh) induces stromal expansion and metaplasia in the adult
murine pancreas.
Neoplasia. 2011 Oct;13(10):923-30.
Feldmann G*, Mishra A*, Bisht S, Garrido-Laguna I, Rasheed Z, Ottenhof NA, Dadon T, Alvarez H,
Fendrich V, Rajeshkumar NV, Matsui W, Brossart P, Hidalgo M, Bannerji R, Maitra A, Nelkin BD. (* equal
contribution).
Cyclin-dependent kinase inhibitor SCH727965 inhibits pancreatic cancer growth and progression in
murine xenograft models.
Cancer Biol Ther. 2011 Oct 1;12(7):598-609.
Feldmann G, Karikari C, dal Molin M, Duringer S, Volkmann P, Bartsch DK, Bisht S, Koorstra JB, Brossart
P, Maitra A, Fendrich V. Inactivation of Brca2 Cooperates with Trp53R172H to Induce Invasive Pancreatic
Ductal Adenocarcinomas in Mice: A Mouse Model of Familial Pancreatic Cancer.
Cancer Biol Ther. 2011 Jun 1;11(11):959-68.
Feldmann G*, Mishra A*, Hong SM, Bisht S, Strock CJ, Ball DW, Goggins M, Maitra A, Nelkin BD. (* equal
contribution)
Cyclin-dependent kinase 5 (CDK5) promotes pancreatic cancer tumorigenicity and progression through
the Ral effector pathway: Therapeutic implications for Ras inhibition in cancer.
Cancer Res. 2010 Jun 1;70(11):4460-9.
Mullendore ME, Koorstra JM, Li Y, Offerhaus GJ, Fan X, Henderson CM, Matsui W, Eberhart CG, Maitra A,
Feldmann G.
Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic
cancer.
Clin Cancer Res. 2009 Apr 1;15(7):2291-301.
Bisht S*, Feldmann G*, Koorstra JM, Mullendore M, Alvarez H, Karikari C, Rudek MA, Lee CK, Maitra A,
Maitra A. (*equal contribution)
An orally bioavailable polymeric nanoparticle formulation of rapamycin (nanorapamycin) for systemic
cancer therapy.
Mol Cancer Ther. 2008 Dec;7(12):3878-88.
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Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, Koorstra JM, Habbe N, Karikari C,
Mullendore M, Gabrielson KL, Sharma R, Matsui W, Maitr A.
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and
metastasis in pancreatic cancer.
Mol Cancer Ther. 2008 Sep;7(9):2725-35.
Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C,
Bardeesy N, Oullette MM, Yu W, Maitra A.
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.
Gut. 2008 Oct;57(10):1420-30.
Fendrich V, Waldmann J, Esni F, Ramaswamy A, Mullendore M, Buchholz M, Maitra A, Feldmann G.
Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum.
Endocr Relat Cancer. 2007 Sep;14(3):865-74.
Feldmann G*, Dhara S*, Fendrich V, Bedja D, Beaty R, Mullendore M, Karikari C, Alvarez H, IacobuzioDonahue C, Jimeno A, Gabrielson KL, Matsui W, Maitra A. (*equal contribution)
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for
combination therapy in solid cancers.
Cancer Res. 2007 Mar 1;67(5):2187-96.
Kassauei K, Habbe N, Mullendore ME, Karikari CA, Maitra A, Feldmann G.
Mitochondrial DNA mutations in pancreatic cancer.
Int J Gastrointest Cancer. 2006;37(2-3):57-64.
Feldmann G*, Nischalke HD*, Nattermann J, Banas B, Berg T, Teschendorf C, Schmiegel W, Duhrsen U,
Halangk J, Iwan A, Sauerbruch T, Caselmann WH, Spengler U. (*equal contribution)
Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed
cryoglobulinemia and B-cell non-Hodgkin's lymphoma.
Clin Cancer Res. 2006 Aug 1;12(15):4491-8.
Feldmann G, Nattermann J, Nischalke HD, Gorschluter M, Kuntzen T, Ahlenstiel G, Gerhardt T, Wolff M,
Sauerbruch T, Spengler U, Dumoulin FL.
Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology
specimens from patients with bile duct cancer.
Endoscopy. 2006 Jun;38(6):604-9.
Original articles, co-authorships:
Meschenmoser K, Kim Y, Franken S, Nowak M, Feldmann G, Bendas G, Wolfgarten M, Messmer D,
Schmidt-Wolf I. Targeting Cancer with a bi-functional Peptide: In Vitro and In Vivo results.
In Vivo. 2013 Jul-Aug;27(4):431-42.
Kamiyama H, Rauenzahn S, Shim JS, Karikari CA, Feldmann G, Hua L, Kamiyama M, Schuler FW, Lin MT,
Beaty RM, Karanam B, Liang H, Mullendore ME, Mo G, Hidalgo M, Jaffee E, Hruban RH, Jinnah HA, Roden
RB, Jimeno A, Liu JO, Maitra A, Eshleman JR. Personalized chemotherapy profiling using cancer cell lines
from selectable mice.
Clin Cancer Res. 2013 Mar 1;19(5):1139-46.
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Bauer I, Grozio A, Lasiglie' D, Basile G, Sturla L, Magnone M, Sociali G, Soncini D, Caffa I, Poggi A, Zoppoli
G, Cea M, Feldmann G, Mostoslavsky R, Ballestrero A, Patrone F, Bruzzone S, Nencioni A.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in
pancreatic cancer cells by regulating Ca2+ responses.
J Biol Chem. 2012 Nov 30;287(49):40924-37. doi: 10.1074/jbc.M112.405837. Epub 2012 Oct 18.
Nischalke HD, Schmitz V, Luda C, Aldenhoff K, Berger C, Feldmann G, Sauerbruch T, Spengler U,
Nattermann J. Detection of IGF2BP3, HoxB7, and NEK2 mRNA expression in brush cytology specimens as
a new diagnostic tool in patients with biliary strictures.
PLoS One. 2012;7(8):e42141. doi: 10.1371/journal.pone.0042141. Epub 2012 Aug 7.
Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A,
Mendell JT.
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward
pathway.
Genes Dev. 2010 Dec 15;24(24):2754-9.
Alvarez H, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM,
Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa JC,
Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A.
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal
adenocarcinoma.
Cancer Biol Ther. 2010 Nov 29;10(10):1009-18. Epub 2010 Nov 15.
Bisht S, Mizuma M, Feldmann G, Ottenhof NA, Hong SM, Pramanik D, Chenna V, Karikari C, Sharma R,
Goggins MG, Rudek MA, Ravi R, Maitra A, Maitra A.
Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor
Growth and Metastases in Preclinical Models of Pancreatic Cancer.
Mol Cancer Ther. 2010 Aug;9(8):2255-64. Epub 2010 Jul 20.
Kamiyama M, Kamiyama H, Karikari C, Hong SM, Feldmann G, Lin MT, Shi C, Griffith M, Liang H,
Goggins M, Maitra A, Hruban RH, Eshleman JR.
In vivo and in vitro propagation of Intraductual Papillary Mucinous Neoplasms.
Lab Invest. 2010 May;90(5):665-73. Epub 2010 Mar 15.
Fendrich V*, Chen NM*, Neef M, Waldmann J, Buchholz M, Feldmann G, Slater EP, Maitra A, Bartsch DK.
(*equal contribution)
The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic
intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic
cancer.
Gut. 2010 May;59(5):630-7. Epub 2009 Nov 1.
Waldmann J, Slater EP, Langer P, Buchholz M, Ramaswamy A, Walz MK, Schmid KW, Feldmann G,
Bartsch DK, Fendrich V.
Expression of the transcription factor snail and its target gene twist are associated with malignancy in
pheochromocytomas.
Ann Surg Oncol. 2009 Jul;16(7):1997-2005. Epub 2009 May 2.
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Lee KH, Lottermann C, Karikari C, Omura N, Feldmann G, Habbe N, Goggins M, Mendell J, Maitra A.
Epigenetic Silencing of MicroRNA miR-107 Regulates Cyclin-dependent Kinase 6 (CDK6) Expression in
Pancreatic Cancer.
Pancreatology. 2009;9(3):293-301. Epub 2009 Apr 29.
Fendrich V, Waldmann J, Feldmann G, Schlosser K, Konig A, Ramaswamy A, Bartsch DK, Karakas E.
Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant
parathyroid neoplasia.
Eur J Endocrinol. 2009 Apr;160(4):695-703. Epub 2009 Jan 28.
Koorstra JM, Karikari C, Feldmann G, Bisht S, Leal-Rojas P, Offerhaus GJA, Alvarez H, Maitra A.
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and
represents a new therapeutic target.
Cancer Biol Ther. 2009 Apr;8(7):618-26. Epub 2009 Apr 22.
Jimeno A, Feldmann G, Suárez-Gauthier A, Rasheed Z, Solomon A, Zou GM, Rubio-Viqueira B, GarcíaGarcía E, López-Ríos F, Matsui W, Maitra A, Hidalgo M.
A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.
Mol Cancer Ther. 2009 Feb;8(2):310-4. Epub 2009 Jan 27.
Ahlenstiel G, Woitas RP, Iwan A, Nattermann J, Feldmann G, Rockstroh JK, Oldenburg J, Kupfer B,
Sauerbruch T, Spengler U.
Effects of the CCR5-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses in Patients with
Haemophilia.
Immunol Invest. 2009;38(1):1-13.
Habbe N, Koorstra JB, Mendell JT, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG, Hong
SM, Maitra A.
MicroRNA miR-155 is a biomarker of early pancreatic neoplasia.
Cancer Biol Ther. 2009 Feb;8(4):340-6. Epub 2009 Feb 3.
Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach
SD, Maitra A.
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting
of oncogenic Kras in adult mice.
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8. Epub 2008 Nov 21.
Waldmann J, Feldmann G, Slater EP, Langer P, Buchholz M, Ramaswamy A, Saeger W, Rothmund M,
Fendrich V.
Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with
decreased survival.
Br J Cancer. 2008 Dec 2;99(11):1900-7. Epub 2008 Nov 18.
Cheung W, Darfler MM, Alvarez H, Hood BL, Conrads TP, Habbe N, Krizman DB, Mollenhauer J,
Feldmann G, Maitra A.
Application of a Global Proteomic Approach to Archival Precursor Lesions: Deleted in Malignant Brain
Tumors 1 and Tissue Transglutaminase 2 Are Upregulated in Pancreatic Cancer Precursors.
Pancreatology. 2008 Oct 13;8(6):608-616.
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Fendrich V, Esni F, Garay MV, Feldmann G, Habbe N, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD,
Maitra A.
Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas.
Gastroenterology. 2008 Aug;135(2):621-31. Epub 2008 Apr 16.
Alvarez H, Corvalan A, Roa JC, Argani P, Murillo F, Edwards J, Beaty R, Feldmann G, Hong SM,
Mullendore M, Roa I, Ibañez L, Pimentel F, Diaz A, Riggins GJ, Maitra A.
Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic
biomarker in gallbladder cancer.
Clin Cancer Res. 2008 May 1;14(9):2631-8.
Kuntzen T, Tural C, Li B, Feldmann G, Kupfer B, Nischalke HD, Clotet B, Sauerbruch T, Rockstroh JK,
Spengler U.
Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells,
cytokines, and influence of HAART.
AIDS. 2008 Jan 11;22(2):203-10.
Tan AC, Fan JB, Karikari C, Bibikova M, Garcia EW, Zhou L, Barker D, Serre D, Feldmann G, Hruban RH,
Klein AP, Goggins M, Couch FJ, Hudson TJ, Winslow RL, Maitra A, Chakravarti A.
Allele-specific expression in the germline of patients with familial pancreatic cancer: An unbiased
approach to cancer gene discovery.
Cancer Biol Ther. 2007 Oct 19;7(1)
Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D.
Elucidation of a universal size-control mechanism in Drosophila and mammals.
Cell. 2007 Sep 21;130(6):1120-33.
Hofmann WP, Fernandez B, Herrmann E, Welsch C, Mihm U, Kronenberger B, Feldmann G, Spengler U,
Zeuzem S, Sarrazin C.
Somatic hypermutation and mRNA expression levels of the BCL-6 gene in patients with hepatitis C virusassociated lymphoproliferative diseases.
J Viral Hepat. 2007 Jul;14(7):484-91.
Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M,
Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT.
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.
Mol Cell. 2007 Jun 8;26(5):745-52.
Foss CA, Fox JJ, Feldmann G, Maitra A, Iacobuzio-Donohue C, Kern SE, Hruban R, Pomper MG.
Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of
pancreatic cancer.
Mol Imaging. 2007 Apr-Jun;6(2):131-9.
Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, Maitra A.
Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer
therapy.
J Nanobiotechnology. 2007 Apr 17;5:3.
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Karikari CA, Roy I, Tryggestad E, Feldmann G, Pinilla C, Welsh K, Reed JC, Armour EP, Wong J, Herman J,
Rakheja D, Maitra A.
Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the Xlinked inhibitor of apoptosis protein.
Mol Cancer Ther. 2007 Mar;6(3):957-66.
Gerhardt T, Milz S, Schepke M, Feldmann G, Wolff M, Sauerbruch T, Dumoulin FL.
C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma.
World J Gastroenterol. 2006 Sep 14;12(34):5495-500.
von Lilienfeld-Toal M, Nattermann J, Feldmann G, Sievers E, Frank S, Strehl J, Schmidt-Wolf IG.
Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show
cytotoxic activity against myeloma cells.
Clin Exp Immunol. 2006 Jun;144(3):528-33.
Sui G, Bonde P, Dhara S, Broor A, Wang J, Marti G, Feldmann G, Duncan M, Montgomery E, Maitra A,
Harmon JW.
Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells
from rat reflux model.
J Surg Res. 2006 Jul;134(1):1-9.
Nattermann J, Ahlenstiel G, Berg T, Feldmann G, Nischalke HD, Muller T, Rockstroh J, Woitas R,
Sauerbruch T, Spengler U.
The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection.
J Viral Hepat. 2006 Jan;13(1):42-6.
Nattermann J, Feldmann G, Ahlenstiel G, Langhans B, Sauerbruch T, Spengler U.
Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C.
Gut. 2006 Jun;55(6):869-77.
Nattermann J, Nischalke HD, Hofmeister V, Kupfer B, Ahlenstiel G, Feldmann G, Rockstroh J, Weiss EH,
Sauerbruch T, Spengler U.
HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.
Antivir Ther. 2005;10(1):95-107.
Nattermann J, Nischalke HD, Feldmann G, Ahlenstiel G, Sauerbruch T, Spengler U.
Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5.
J Viral Hepat. 2004 Nov;11(6):519-26.
Saller B, Feldmann G, Haupt K, Broecker M, Janssen OE, Roggendorf M, Mann K, Lu M.
RT-PCR-based detection of circulating calcitonin-producing cells in patients with advanced medullary
thyroid cancer.
J Clin Endocrinol Metab. 2002 Jan;87(1):292-6.
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Review articles:
Matthaei H, Feldmann G, Lingohr P, Kalff JC.
Molecular diagnostics of pancreatic cysts.
Langenbecks Arch Surg. 2013 Dec;398(8):1021-7. doi: 10.1007/s00423-013-1116-z. Epub 2013 Sep 26.
Bisht S, Feldmann G, Brossart P. Pharmacokinetics and pharmacodynamics of sunitinib for the treatment
of advanced pancreatic neuroendocrine tumors.
Expert Opin Drug Metab Toxicol. 2013 Jun;9(6):777-88. doi: 10.1517/17425255.2013.791281. Epub 2013
Apr 16. Review.
Feldmann G, Bisht S, Schütte U, Haarmann J, Brossart P.
Everolimus for the treatment of pancreatic neuroendocrine tumors.
Expert Opin Pharmacother. 2012 Oct;13(14):2073-84. doi: 10.1517/14656566.2012.713348. Epub 2012
Aug 8. Review.
Schütte U, Bisht S, Brossart P, Feldmann G.
Recent developments of transgenic and xenograft mouse models of pancreatic cancer for translational
research.
Exp Opinion Drug Disc 2011 January , Volume 6, Number 1.
Bisht S, Brossart P, Maitra A, Feldmann G.
Agents targeting the Hedgehog pathway for pancreatic cancer treatment.
Curr Opin Investig Drugs. 2010 Dec;11(12):1387-1398.
Feldmann G, Rauenzahn S, Maitra A.
In vitro models of pancreatic cancer for translational oncology research.
Expert Opin Drug Disc. 2009;4(4):429-43
Koorstra JB, Feldmann G, Habbe N, Maitra A.
Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs).
Langenbecks Arch Surg. 2008 Feb 19.
Feldmann G, Maitra A.
Molecular Genetics of Pancreatic Ductal Adenocarcinomas and Recent Implications for Translational
Efforts.
J Mol Diagn. 2008 Feb 7.
Feldmann G, Beaty R, Hruban RH, Maitra A.
Molecular genetics of pancreatic intraepithelial neoplasia.
J Hepatobiliary Pancreat Surg. 2007;14(3):224-32.
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Case reports:
Feldmann G, Brossart P, Zipfel M, von Lilienfeld-Toal M. Mixed response to ipilimumab in a melanoma
patient with brain metastases: case report and review of the literature.
Case Rep Oncol. 2013 Apr 20;6(1):229-35.
Feldmann G, Brossart P, von Lilienfeld-Toal M. Transient and fully reversible leukocytosis in a
myelodysplastic syndrome patient upon initiation of azacitidine treatment.
Ann Hematol. 2013 Apr 13.
Feldmann G, Nattermann J, Gerhardt T, Nähle CP, Spengler U, Woitas R.
Partial remission of a newly diagnosed diffuse large B-cell non-Hodgkin's lymphoma in a hemodialysis
patient after administration of immuno-chemotherapy with rituximab-CHOP.
Int J Lab Hematol. 2007 Dec;29(6):469-73.
Book chapters:
Feldmann G, Maitra A.
Methylation detection and epigenomics in pancreatic cancer; in: Drug Discovery in Pancreatic Cancer:
Models and Techniques. Editors-in-Chief: Han H, Grippo PJ.
2010, Springer; 1st Edition. edition (March 18, 2010); ISBN-10: 1441911596; ISBN-13: 978-1441911599
Feldmann G, Maitra A.
Molecular pathology of precursor lesions to pancreatic cancer: PanINs, IPMNs, mucinous cystic
neoplasms; in: Handbook of Pancreatic Cancer. Editors-in-Chief: Neoptolemus J, Buchler M,
Abbruzzese J, Urrutia R.
2009, Springer, Berlin; Auflage: 1; ISBN-10: 0387774998; ISBN-13: 978-0387774992
Patents:
Maitra A, Feldmann G, Bisht S.
Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart
polymeric nanoparticles.
United States patent application number 20080107749.
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Abstracts:
Feldmann G, Karikari C, dal Molin M, Duringer S, Volkmann P, Bartsch DK, Bisht S, Koorstra JB, Brossart
P, Maitra A, Fendrich V. Inactivation of Brca2 cooperates with Trp53(R172H) to induce invasive
pancreatic ductal adenocarcinomas in mice A mouse model of familial pancreatic cancer. ASCO Annual
Meeting 2011
Schütte U, Bisht S, Beckers A, Esch C, Heukamp LC, Zhou H, Buettner R, Brossart P, Feldmann G.
Expression of Yes-associated protein (YAP) in clear cell renal cell carcinoma. Onkologie 2010;33(Suppl.6),
128-128
Feldmann G, Rauenzahn S, Mullendore M, Bisht S, Karikari C, Iacobuzio-Donahue C, Fendrich V, Maitra
A. No evidence for somatic mutations within smoothened (SMO) or suppressor-of-fused (SuFu) in
pancreatic cancer by direct sequencing. Onkologie 2009;32(Suppl.4) P509
Feldmann G, Mishra A, Hong SM, Bisht S, Strock CJ, Ball DW, Goggins M, Maitra A, Nelkin BD. Activation
of cyclin-dependent kinase 5 (CDK5) mediates tumor initiation and progression in in vitro and in vivo
model systems of pancreatic cancer through interaction with the RALGDS/RAL signal transduction
pathway. Onkologie 2009;32(Suppl.4) V865
Feldmann G, Mishra A, Strock C, Ball D, Maitra A, Nelkin B. CDK5 INHIBITION DIMINISHES PANCREATIC
CANCER TUMORIGENESIS AND METASTASIS. Pancreas 2008;37(4),469-470
Habbe N, Koorstra JBM, Mendell JR, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG,
Hong SM, Maitra A. MICRORNA MIR-155 IS A BIOMARKER OF EARLY PANCREATIC NEOPLASIA. Pancreas
2008;37(4),473-473
Nischalke HD, Schmitz V, Aldenhoff K, Feldmann G, Sauerbruch T, Spengler U, Nattermann J.
VALIDATION OF IGF2BP3, HOXB7, AND NEK2 MRNA EXPRESSION IN BRUSH CYTOLOGY SPECIMENS AS
SPECIFIC AND SENSITIVE DIAGNOSTIC MARKERS FOR BILE DUCT CANCER. Hepatology 2008;48(4), 944A
Feldmann G, Strock CJ, Mishra A, Ball DW, Maitra A, Nelkin BD. CDK5 inhibition suppresses pancreatic
cancer tumorigenesis and metastasis. Mol Cancer Ther 2007;6(12): 3548S-3548S
Habbe N, Meguid RA, Fendrich V, Feldmann G, Hruban RH, Leach SD, Maitra A. Spontaneous
development of murine pancreatic intraepithelial neoplasia (MPanIN) in Ela-CreERT2; LSL-Kras(G12D)
mice: Insights into cellular origins of pancreatic cancer. Pancreas 2007;35(4):405-406
Fendrich V, Esni F, Feldmann G, Megiud R, Leach S, Maitra A. Hedgehog pathway activation in acute
injury and regeneration in adult mouse pancreas. Pancreas 2006:33(4):460-460
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Feldmann G, Dhara S, Beaty R, Alvarez H, Fendrich V, Rauenzahn S, Mullendore M, Karikari C, Maitra A.
The Hedgehog pathway as potential new therapeutic target in pancreatic cancer. Johns Hopkins
University Department of Pathology Yound Investigator Day 2006
Hofmann WP, Fernandez B, Hermann E, Mihm U, Feldmann G, Spengler U, Zeuzem S, Sarrazin C.
Mutational frequency and mRNA expression levels of the BCL-6 gene in patients with hepatitis C virusassociated mixed cryoglobulinemia and B cell non Hodgkin lymphoma. Hepatology 2005;42(4):552A
Suppl. 1.
Nattermann J, Feldmann G, Nischalke HD, Sauerbruch T, Spengler U. Expression and function of C-type
lectin-like receptors in chronic hepatitis C. Gastroenterology 2005;128(4):A712 Suppl. 2.
Nattermann J, Feldmann G, Nischalke HD, Sauerbruch T, Spengler U. Impact of viremic HCV infection on
surface expression of NK cell receptors and cytolytic function of NK cells. J Hepatology 2005;42:21 Suppl.
2.
Feldmann G, Nattermann J, Banasch B, Nischalke HD, Ahlenstiel G, Kuntzen T, Schulz M, Woitas R,
Teschendorf C, Schmiegel W, Sauerbruch T, Spengler U. Induction of interleukin-6 by HCV core protein in
patients with HCV-associated cryoglobulinemia and B-cell non-Hodgki ’s ly pho a. J Hepatology
2005;42:157 429 Suppl. 2.
Hofmann WP, Mihm U, Fernandez B, Kronenberger B, Spengler U, Feldmann G, Zeuzem S, Sarrazin C.
Mutational frequency of the BCL-6 genen in patients with hepatitis C virus-associated mixed
cryoglobulinemia and malignant B-cell Non-Hodgkin lymphoma. J Hepatol 2005;42:159 436 Suppl. 2.
Nattermann J, Feldmann G, Nischalke HD, Langhans B, Sauerbruch T, Spengler U. Enhanced intrahepatic
expression of HLA-E and NKG2A in chronic hepatitis C. J Hepatol 2005;42:163 448 Suppl. 2.
Feldmann G, Nischalke HD, Nattermann J, Gerhardt T, Gorschlüter M, Kuntzen T, Ahlenstiel G, Wolff M,
Sauerbruch T, Spengler U, Dumoulin FL. Nachweis von Aspartyl (asparaginyl) beta-hydroxylase- und
Homeo box B7-mRNA aus intraduktalen Bürstenabstrichen bei Patienten mit cholangiozellulären
Karzinomen. 179. Jahrestagung der Rheinisch-Westfälischen Gesellschaft für Innere Medizin.
Feldmann G, Nischalke HD, Nattermann J, Gerhardt T, Gorschlüter M, Kuntzen T, Ahlenstiel G, Wolff M,
Sauerbruch T, Spengler U, Dumoulin FL. Detection of human aspartyl (asparaginyl) beta-hydroxylase and
homeo box B7 mRNA in brush cytology specimens from patients with cholangiocellular carcinoma.
Hepatology 2004;40(4):301A Suppl. 1.
Nattermann J, Ahlenstiel G, Nischalke HD, Feldmann G, Kuntzen T, von Lilienfeld-Toal M, Langhans B,
Sauerbruch T, Spengler U. Reduced surface expression of natural cytotoxicity receptors (NKP46, NKP30
and NKP44) results in impaired NK cell cytolytic function in viremic HCV infection. Hepatology
2004;40(4):450A Suppl. 1.
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Nattermann J, Ahlenstiel G, Nischalke HD, Feldmann G, Kuntzen T, Sauerbruch T, Spengler U. Enhanced
expression of CD94/NKG2A on CD8+ T lymphocytes in viremic HCV patients is associated with an
impaired lytic function of CTL. Hepatology 2004;40(4):450A Suppl. 1.
Nattermann J, Nischalke HD, Ahlenstiel G, Feldmann G, Sauerbruch T, Spengler U. CD8+ lymphocytes are
an important source of RANTES secretion in hepatitis C virus infection. Gastroenterology
2004;126(4):A764 Suppl. 2.
von Lilienfeld-Toal M, Nattermann J, Feldmann G, Schmidt-Wolf IGH. Isolated  T cells express natural
cytotoxicity receptors. Cancer Immunotherapy 2nd Annual Meeting 2004.
von Lilienfeld-Toal M, Nattermann J, Feldmann G, Schmidt-Wolf IGH. Activated  T cells express the
natural cytotoxicity receptor Nkp44. 9th Congress of the European Hematology Association 2004.
Feldmann G, Nattermann J, Banas B, Nischalke HD, Ahlenstiel G, Kuntzen T, Schulz M, Woitas R,
Sauerbruch T, Spengler U. HCV core Protein-vermittelte Induktion von Interleukin-6 und Interleukin-8
bei HCV-assoziierten hepatozellulären Karzinomen, Kryoglobulinämien und B-Zell Non-HodgkinLymphomen. Deutsche Gesellschaft für Verdauung und Stoffwechsel. Z Gastroenterol 2004; abstract
P240.
Kuntzen T, Tural C, Feldmann G, Leifeld L, Wolff M, Dumoulin FL, Nischalke HD, Clotet B, Sauerbruch T,
Spengler U, Rockstroh JK. Increased RANTES steady state mRNA levels in liver biopsies of HIV/HCV
coinfected patients. J Hepatol 2004;40:119 401 Suppl. 1.
Nattermann J, Nischalke HD, Ahlenstiel G, Feldmann G, Sauerbruch T, Spengler U. Binding of the
hepatitis C virus envelope E2 protein to CD81 results in reduced responsivness of cd8+ lymphocytes to
CC chemokines. J Hepatol 2004;40:121 408 Suppl. 1.
Nattermann J, and Ahlenstiel G, Feldmann G, Nischalke HD, Berg T, Rockstroh J, Woitas R, Sauerbruch T,
Spengler U. The DC-SIGNR tandem-repeat polymorphism in hepatitis C virus infection. J Hepatol
2004;40:121 409 Suppl. 1.
Zimmermann H, Nattermann J, Leifeld L, Nischalke HD, Ahlenstiel G, Feldmann G, Sauerbruch T,
Spengler U. Reduced intrahepatic expression of DC-SIGNR in chronic hepatitis C virus infection. J Hepatol
2004;40:124 420 Suppl. 1.
Nattermann J, Ahlenstiel G, Nischalke HD, Feldmann G, Berg T, Rockstroh J, Woitas R, Sauerbruch T,
Spengler U. Die Bedeutung des DC-SIGNR Polymorphismus in der HCV-Infektion. Med Klin 2004.
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Nattermann J, Ahlenstiel G, Nischalke HD, Feldmann G, Berg T, Rockstroh J, Woitas R, Sauerbruch T,
Spengler U. Der Tandem-Repeat Polymorphismus des DC-SIGNR Gens in der HCV Infektion. Deutsche
Gesellschaft für Verdauung und Stoffwechsel. Z Gastroenterol 2004.
Nattermann J, Nischalke HD, Feldmann G, Hofmeister V, Rockstroh J, Weiss EH, Sauerbruch T,
Spengler U. The HIV T cell epitope p24 aa14-21 stabilizes HLA-E expression resulting in impaired
cytotoxic function of natural killer cells. 9th European Aids Conference (EACS) 2003; abstract 84.
Nattermann J, Nischalke HD, Feldmann G, Sauerbruch T, Spengler U. Enhanced expression of
CD94/NKG2A on CD8+ T lymphocytes from HCV-positive Patients. Hepatology 2003;38(4):446A 633
Suppl. 1.
Nattermann J, and Ahlenstiel G, Feldmann G, Nischalke HD, Vogel M, Berg T, Rockstroh J, Woitas R,
Sauerbruch T, Spengler U. The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection.
Hepatology 2003;38(4):466A 634 Suppl. 1.
Nattermann J, Nischalke HD, Feldmann G, Sauerbruch T, Spengler U. Die Bindung von HCV E2 an CD81
stimuliert die Freisetzung von RANTES und resultiert in einer Reduktion der CCR5
Oberflächenexpression. Z Gastroenterol 2003;36:4 abstract P 183.
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