Collaborative Group of the Americas on Inherited Colorectal Cancer

10th Annual Meeting of the
Collaborative Group
of the Americas on
Inherited Colorectal Cancer
November 9-10, 2006
DoubleTree Hotel Nashville
315 4th Avenue North
Nashville, Tennessee
Photo: Barry M. Winiker
Preceding The National Society of Genetic Counselors (NSGC)
meeting held at the Gaylord Opryland Resort.
10th Annual Meeting of the
Collaborative Group of the Americas
on Inherited Colorectal Cancer
Goal
This program was developed in recognition of the need for clinicians and scientists
to keep abreast of current information in hereditary colorectal cancer research –
including its implications in the prevention, diagnosis and treatment of patients with
colorectal cancer. Increasing emphasis will be on awareness of and participation in
development of clinical and translational trials.
Educational Objectives
(per Accreditation Council for Continuing Medical
Education guidelines)
After attending the conference, participants should be able to
• review the molecular genetics of inherited colorectal cancer;
• describe clinical features of common inherited colorectal cancer syndromes;
• describe emerging research in hereditary colorectal cancer, including clinical, basic
science, and psychosocial issues;
• review chemoprevention treatment options for inherited colorectal cancer;
• identify and resolve difficult case management issues in the treatment of hereditary
colorectal cancer;
• discuss the role of genetic counseling and hereditary colorectal cancer registries in
providing patient education and promotion of interaction between patients and
researchers.
Learning Objectives
(per American Board of Genetic Counselors’ guidelines)
• Appreciate the ethical, legal, and psychosocial issues unique to hereditary colon
cancer risk identification, management, and documentation.
• Increase participants’ understanding of new screening, surgical, and research
options available to their high risk patients.
• Examine the impact of genetic evaluation, genetic counseling, and genetic testing
on clinical care of individuals and families.
Target Audience
This conference will be beneficial to colorectal surgeons, medical oncologists,
gastroenterologists, researchers, geneticists, nurses, colorectal cancer registry
coordinators, genetic counselors, and psychologists involved in hereditary colorectal
cancers.
Educational Methods
Lectures - Question and Answer Sessions - Panel Discussions - Case Presentations Exhibit Program
Evaluation
A course evaluation form will provide participants with the opportunity to review
each session and speaker, to identify future educational needs, and to comment on
any perceived commercial bias in the presentations.
Accreditation/Credit Designation
This activity has been planned and implemented in accordance with the Essential
Areas and Policies of the Accreditation Council for Continuing Medical Education
(ACCME) through this joint sponsorship of The University of Texas M. D.
Anderson Cancer Center and The Collaborative Group of the Americas on
Inherited Colorectal Cancer. The University of Texas M. D. Anderson Cancer
Center is accredited by the ACCME to provide continuing medical education for
physicians.
The University of Texas M. D. Anderson Cancer Center designates this educational
activity for a maximum of 11.75 AMA PRA Category 1 CreditsTM. Physicians should
only claim credit commensurate with the extent of their participation in the activity.
American Board of Genetic Counselors
The event is co-sponsored by the American Counseling Association (ACA). ACA
is approved by the National Board for Certified Counselors (NBCC) to offer up to
13.0 contact clock hours of continuing education credit. ACA adheres to NBCC
continuing education guidelines. NBCC approved contact hours will be provided by
ACA. ACA offers 10 contact clock hours for every (1) continuing education unit, as
approved by the American Board of Genetic Counseling. The credits offered are
Category 1 CEUs.
Call for Abstracts
Participants are encouraged to submit abstracts regarding clinical, basic science, and
psychosocial aspects of hereditary colorectal cancer. We are interested in abstracts
for both established projects with data to share and newly started projects. Our goal
is to provide a comprehensive update on the status of clinical research and to
stimulate collaborations, recruitment of subjects, and ideas for the development of
other studies.
Abstracts will only be accepted electronically and should be submitted to Larry
Rusin, MD, CGA-ICC Vice President, at [email protected]
The deadline for submission of abstracts is September 8, 2006. Acceptance of
abstracts will be acknowledged by e-mail. Authors will be notified by October 6,
2006. All communication will be with the submitting author only.
Limit abstracts to one page, typed in 12 point Times New Roman font, single-spaced
with one-inch margins and left justified. Organize the abstract into Background,
Methods, Results, and Conclusions. Define all abbreviations and provide three
keywords describing the nature and content of the abstract. Please include the name
of the conference, title of your presentation, full names of all authors, highest degree,
institutional affiliation, and full address at the top of the abstract. Also, please
indicate the presenting author by underlining the appropriate name. Abstracts will
be selected for poster/oral presentations based on scientific merit and content quality.
PROGRAM
Wednesday, November 8, 2006
2:00 - 6:00 pm
Registration/Poster Setup
Thursday, November 9, 2006
7:30 am
Registration/Continental Breakfast
8:25
Welcome
Miguel A. Rodriguez-Bigas, MD
Session: Who and How Do We Select for Mutational
Testing for HNPCC?
8:30
Identifying Patients with Lynch Syndrome
Heather Hampel, MS, CGC
8:45
Lab Diagnosis of Lynch Syndrome
Russell R. Broaddus, MD, PhD
9:00
Lemuel Herrera Memorial Lecture
Lynch Syndrome and Familial Colorectal Cancer Type X
Noralane M. Lindor, MD
9:30
Panel Discussion
10:00
Break
Session: Family History Documentation and Evaluation
10:30
Strategies To Obtain an Accurate Family History
Janet Shenal
10:45
Applying Family History Information to the Genetic
Evaluation
Thuy Vu, MS, CGC
11:00
Networking/Discussion
Angela Schwab, MS, CGC - Moderator
Noon
Box Lunch Pickup
12:30 pm
Working Groups (each concurrent session limited to 40 participants)
Resources for Patient and the Public and CGA Patient ID Tools
Lori Aro; Erin R. Dola, MS, CGC; Anna Leininger, MS, CGC;
Ellen McGannon, BSW
Rare Tumors in HNPCC/Lynch Syndrome
Scott Kuwada, MD and Katrina Lowstuter, MS, CGC
Polyposis Syndromes: Classifications and Genetic Factors
Marc Greenblatt, MD
FAP Chemoprevention
Patrick M. Lynch, MD, JD
1:30
Clinical Science Abstract Oral Presentations
James Church, MD - Moderator
2:30
Invited Lecture:
Dermatologic Findings in Hereditary Colon Cancer Syndromes
Marcus Bosenberg, MD, PhD
3:00
Break
3:30
Challenging Cases
4:45
Adjourn
4:50
Poster Session/Reception
6:30 pm
Dinner
Lifetime Achievement Award
“Growing Up With Henry Lynch”
Patrick M. Lynch, MD, JD
Friday, November 10, 2006
7:30 am
Registration/Continental Breakfast
Session: Diagnostic Challenges in Polyposis
8:30
MYH Missense Variants
Sheila S. David, MD
8:45
Variants of Uncertain Significance
Marc Greenblatt, MD
9:00
Prevalence of APC, MYH and HNPCC Mutations Based on
Polyp Number
Sapna Syngal, MD, PhD
PROGRAM
9:15
Hamartomatous Polyposis
Kevin Zbuk, MD
9:45
Panel Discussion
10:15
Break
10:45
Basic Science Abstract Presentations
11:45
Annual CGA Debate:
Oligopolyposis: Colectomy vs. Surveillance
Arguing for Colectomy: Lawrence Rusin, MD
Arguing for Surveillance: Patrick M. Lynch, MD, JD
12:30 pm
Business Meeting/Election/Buffet Lunch
Session: Updates on Psychosocial Research in
Hereditary Colon Cancer
1:30
Risk Perception/Communication
Suzanne O’Neil, MA, MS, PhD
1:55
Educating Primary Care Clinicians
Elena Stoffel, MD, MHP
2:20
Panel Discussion
Session ends
2:45
Presidential Address and Best Abstract Awards
Miguel A. Rodriguez-Bigas, MD
3:00
Break
3:15
Working Groups (each concurrent session limited to 40 participants)
Colon Stem Cells/Pathology
Bruce Boman, MD
Chemoprevention of Hamartomatous Polyposis Syndromes
Scott Kuwada, MD
Psychosocial Research/Working With Children
Susan K. Peterson, PhD, MPH and Wendy Kohlmann, MS, CGC
Desmoid Working Group
James Church, MD
5:00
Adjourn
6:00 pm
Transportation provided to Gaylord Opryland Resort for those
attending the National Society of Genetic Counselorss Meeting.
Organizing Committee
Miguel A. Rodriguez-Bigas, MD, Chair
M. D. Anderson
Houston, Texas
Susan K. Peterson, PhD, MPH
M. D. Anderson
Houston, Texas
James Church, MD
The Cleveland Clinic Foundation
Cleveland, Ohio
Lawrence Rusin, MD
Lahey Clinic Medical Center
Burlington, Massachusetts
Marc Greenblatt, MD
University of Vermont
Burlington, Vermont
Angela Schwab, MS, CGC
Huntsman Cancer Institute
Salt Lake City, Utah
Anna Leininger, MS, CGC
Minnesota Colorectal Cancer Initiative
Minneapolis, Minnesota
Thuy M. Vu, MS, CGC
M. D. Anderson
Houston, Texas
Katrina Lowstuter, MS, CGC
City of Hope
Duarte, California
Jennifer Anderson
M. D. Anderson
Houston, Texas
Patrick M. Lynch, MD, JD
M. D. Anderson
Houston, Texas
Sharon D. Jackson
M. D. Anderson
Houston, Texas
Ellen McGannon, BSW
The Cleveland Clinic Foundation
Cleveland, Ohio
Joan Schauer, CMP
M. D. Anderson
Houston, Texas
Bobbi J. McGivern, MS, CGC
M. D. Anderson
Houston, Texas
Faculty
Lori Aro
Myriad Genetic Laboratories, Inc.
Salt Lake City, Utah
Katrina Lowstuter, MS, CGC
City of Hope
Duarte, California
Marcus Bosenberg, MD, PhD
University of Vermont
Burlington, Vermont
Patrick M. Lynch, MD, JD
M. D. Anderson
Houston, Texas
Bruce Boman, MD
Thomas Jefferson University
Philadelphia, Pennsylvania
Ellen McGannon, BSW
The Cleveland Clinic Foundation
Cleveland, Ohio
Russell R. Broaddus, MD, PhD
M. D. Anderson
Houston, Texas
Suzanne O’Neil, MA, MS, PhD
Evanston Northwestern Health Care
Evanston, Illinois
James Church, MD
The Cleveland Clinic Foundation
Cleveland, Ohio
Susan K. Peterson, PhD, MPH
M. D. Anderson
Houston, Texas
Sheila S. David, MD
University of Utah
Salt Lake City, Utah
Miguel A. Rodriguez-Bigas, MD
M. D. Anderson
Houston, Texas
Erin R. Dola, MS, CGC
St. Luke’s Regional Medical Center
Boise, Idaho
Lawrence Rusin, MD
Lahey Clinic Medical Center
Burlington, Massachusetts
Marc Greenblatt, MD
University of Vermont
Burlington, Vermont
Angela Schwab, MS, CGC
Huntsman Cancer Institute
Salt Lake City, Utah
Heather Hampel, MS, CGC
The Ohio State University
Columbus, Ohio
Janet Shenal
The Cleveland Clinic Foundation
Cleveland, Ohio
Wendy Kohlmann, MS, CGC
Huntsman Cancer Institute
Salt Lake City, Utah
Elena Stoffel, MD, MHP
Brigham and Women’s Hospital
Boston, Massachusetts
Scott Kuwada, MD
Huntsman Cancer Institute
Salt Lake City, Utah
Sapna Syngal, MD, PhD
Dana-Farber Cancer Institute
Boston, Massachusetts
Anna Leininger, MS, CGC
Minnesota Colorectal Cancer
Initiative
Minneapolis, Minnesota
Thuy Vu, MS, CGC
M. D. Anderson
Houston, Texas
Noralane M. Lindor, MD
Mayo Clinic
Rochester, Minnesota
Kevin Zbuk, MD
The Cleveland Clinic Foundation
Cleveland, Ohio
Registration Information
On-site registration opens at 2:00 p.m. on Wednesday, November 8, 2006 in the
Ballroom Foyer. The opening session of the conference will begin at 8:25 a.m. on
Thursday, November 9, 2006, and the conference will adjourn at 5:00 p.m. on Friday,
November 10, 2006. Advance registration is encouraged as space and materials are
limited. Please see the registration form for applicable fees.
The deadline for advance registration is Friday, October 27, 2006.
There are four ways to register:
• Mail to Department of CME/Conference Services, Unit 1381, The University of
Texas M. D. Anderson Cancer Center, P.O. Box 301439, Houston, TX 77230-1439
• Fax to 713-794-1724
• E-mail to [email protected]
• On-line at www.mdanderson.org/conferences
We accept the following forms of payment:
• Check (payable through U.S. banks only)
• Money order
• Credit cards (MasterCard, VISA, and American Express)
• Cash (on-site registration only)
A receipt and confirmation letter will be sent to you within ten working days of
receipt of your registration. The conference registration fee includes the tuition,
final program syllabus, continental breakfasts, lunches, breaks, and dinner.
Refund/Cancellation Policy
The registration fee, minus a $50 administrative handling fee, is refundable if a
written request is received on or before October 27, 2006. No refunds will be
granted after that date. The request for a registration refund must include the tax
identification number of the company or institution if registration was paid by a
company or institution check. Although no refunds will be granted after October
27, 2006, you may transfer your registration to a colleague. For additional
information, contact CME/Conference Services at 713-792-2223 or toll free at
866-849-5866.
The Department of CME/Conference Services reserves the right to cancel activities
prior to the scheduled date, if low enrollment or other circumstances make it
necessary. Each registrant will be notified either by mail, e-mail, or at the phone
or fax numbers given on the registration form.
In case of activity cancellation, the liability of the Department of CME/Conference
Services is limited to the registration fee. CME/Conference Services will refund the
full registration fee. The Department of CME/Conference Services reserves the right
to limit the number of participants in a program and is not responsible for any
expenses incurred by an individual whose registration is not confirmed and for whom
space is not available.
Special Assistance
Contact the Department of CME/Conference Services at 713-792-2223 or toll free at
866-849-5866 if you have any special dietary or ADA accommodation needs.
Accommodations
• A block of rooms has been reserved for conference attendees at the DoubleTree
Hotel Nashville, 315 4th Avenue, Nashville, TN.
• Early hotel reservation is suggested.
• The hotel phone number is 615-244-8200.
• When you make reservations, be sure to mention the Collaborative Group of the
Americas Conference to be assured of receiving the special meeting rate of $139.00
single or $149.00 double occupancy. Please add 14.25% (Tennessee) state and local
taxes.
• Reservations and deposits received after October 11, 2006, will be confirmed if
space is available and at currently published hotel guest room rates.
Air Travel
The University of Texas M. D. Anderson Cancer Center has a program with
Continental Airlines for discounted air travel. For discounts, call your travel
professional or Continental's MeetingWorks toll free at 800-468-7022. Outside of
the United States, please call your local Continental Airlines Reservation Office.
Also, you may book online at www.continental.com. Enter your Z Code: ZKCS and
Agreement Code: 3L23GL in the Offer Code Box when searching for flights.
Lower fares may be available on the Internet or through your travel agency.
Ground Transportation (prices subject to change)
Taxicabs are available at an estimated cost of $25.00 from Nashville International
Airport to the DoubleTree Hotel.
The Gray Line Airport Express Shuttle services downtown Nashville hotels from
Nashville International Airport. The cost is $12.00 one-way or $18.00 roundtrip.
Service begins at 5:00 a.m. and runs until 11:00 p.m., with departures every 15-20
minutes. Reservations are not required for service from the airport. For further
information check the website at www.graylinenashville.com.
Please let us know what specific topics, issues or questions you wish to see addressed or
emphasized in this activity. Fax or e-mail CME/Conference Services. All responses will be
forwarded to the Program Chair for consideration.
Collaborative Group of the Americas on Inherited
Colorectal Cancer
In 1995, the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGAICC) was established to improve understanding of the basic science of inherited colorectal
cancer and the clinical management of affected families. Its broad aims are to enhance the
study of inherited colorectal cancer through
• education of physicians, allied health-care professionals, patients and their families;
• linkage to clinical and chemoprevention trials;
• integration of molecular and clinical research at local and national levels;
• resource for registry development and support of polyposis, inherited colorectal cancer,
and cancer genetics.
Included among CGA-ICC members are many of the most prestigious international
colorectal cancer registries and clinics. Individual members include colorectal surgeons,
medical oncologists, gastroenterologists, researchers, geneticists, nurses, colorectal cancer
registry coordinators, genetic counselors, and psychologists. Typically, attendance at the
annual meeting ranges from 150-200 individuals which serves to promote personal interactions and collaboration among the participants.
Photo: Randy Piland
Photo: Robin Hood
Photo: Gary Layda
REGISTRATION
10th Annual Meeting of the
Collaborative Group of the Americas on Inherited Colorectal Cancer
November 9-10, 2006
Please register by October 27, 2006
Last Name
First
Title (Mr./ Ms. )
MI
Personal Title (II, Jr.)
Degree
State
Zip
Specialty
Department
Hospital Affiliation
Address 1
Address 2
City
Phone
Cell
Fax
E-mail
Registration
$400.00 Physicians
$250.00 Genetic Counselors & Coordinators
$50.00 Late registration-after October 27, 2006
$40.00 for each additional dinner guest
Total enclosed
The University of Texas M. D. Anderson Cancer Center has implemented a process whereby everyone who is in a
position to control the content of an educational activity must disclose all relevant financial relationships with any commercial interest that could potentially affect the information presented. M. D. Anderson also requires that all faculty
disclose any unlabeled use or investigational use (not yet approved for any purpose) of pharmaceutical and medical
device products. Specific disclosure will be made to the participants prior to the educational activity.
Agendas are subject to change because we are always striving to improve the quality of your educational experience.
M. D. Anderson may substitute faculty with comparable expertise on rare occasions necessitated by illness, scheduling
conflicts, and so forth.
Audiotaping or videotaping is prohibited.