annual report 2013-2014

Transcription

Moving with the Nation
NATIONAL INSTITUTE OF
MENTAL HEALTH AND NEURO SCIENCES
An Institute of National Importance
BANGALORE - 560 029
ANNUAL REPORT
2013-2014
NIMHANS
An Institute of National Importance
T
he National Institute of Mental Health and Neuro
Sciences (NIMHANS) is a multidisciplinary Institute for
patient care and academic pursuit in the field of mental health
and neurosciences.
NIMHANS is synonymous with providing high standards
of clinical care, quality training and cutting-edge research in
frontier areas of the brain and mind. The Institute, with its
philosophical underpinning of an integrated and multidisciplinary
approach and its cognizance of societal needs, has prioritised its
objectives as providing comprehensive patient care, manpower
development and research. At the institute, advances in
genomics, computational neuroscience, mathematical modelling,
neuroimaging, molecular biology and a host of new disciplines
including public health are being translated to help society and
also promote the growth of knowledge. Ever since its inception,
a special feature of this Institute is combining research and
training with promotive, preventive and curative aspects of
clinical services in Mental Health and Neurosciences. This
ethos continues to the present day. NIMHANS represents a
unique model of a successful partnership between the Union and
State Governments (Ministry of Health and Family Welfare,
Prof. M.V. Govindaswamy
Founder Director
1954 - 1961
Government of India and the Government of Karnataka).
The manpower development programmes at NIMHANS
reflect the extent to which the Institute has succeeded in
integrating and nurturing disciplines such as behavioural
sciences, neurosciences, basic biological sciences and ancient
health systems under one roof. The Institute frequently
provides advice to the Central and State Governments in
the matter of policies and strategies for mental health care,
evolving the national programme for mental health and
improving psychiatric facilities in the country. The Institute
has also emerged as the nodal centre for evolving national
policies in the field of mental health, neurosciences and injury.
NIMHANS is today a centre for excellence in the country
for mental health and neuroscience. The institute has produced
more than 1,000 Psychiatrists, about 600 Clinical Psychologists
and Psychiatric Nurses so far. Alumni from NIMHANS are
spread across the country and the world.
Recognising its eminent academic position, and the growth in
size and stature, the central government declared NIMHANS
a ‘Deemed University’ in 1994 and in 2012 NIMHANS has
become an ‘Institute of National Importance’.
Vision
To be a world leader in The
area of MenTal healTh and neurosciences and
evolve sTaTe-of-The-arT approaches To paTienT care
Through TranslaTional research
Mission

Establish the highest standards of evidence-based
care for psychiatric and neurological disorders and
rehabilitation

Develop expertise and set standards of care for
diseases of public health relevance in the developing
world

Work with the government and provide consultancy
services for policy planning and monitoring
strategies in the field of Mental Health and
Neurosciences and facilitate execution of national
health programme.

Human resource capacity building by training
in diverse fields related to Mental Health and
Neurosciences.


Develop and strengthen inter-disciplinary, interinstitutional and international collaboration with
universities and research institutes across the globe
to foster scientific research, training in advanced
technology and exchange of ideas in the areas of
Mental Health and Neurosciences.
Strive to enhance equitable accessibility of primary
care in Mental Health and Neurological Disorders
to all sections of society and ages including the
vulnerable population

Evolve and monitor the strategies for disaster
management and psycho-social rehabilitation in
different cultural and ethnic groups.

Promote Mental Health literacy and eliminate the
stigma attached to the Mental and Neurological
illnesses by taking the measures and the delivery
system to the centres of primary health care
honouring the human rights and dignity

Integrate allopathic and oriental medicine into health
care delivery and promote evidence-based research

Integrate physical and metaphysical aspects of
Neuroscience research to promote yoga and its
application to positive mental health.

Participate in broad field of Neuroscience and
Behavioral Research applicable to human ethics,
organ transplantation, stem cell research, space
science, and nuclear science.
Special
Officer
Biostatistics
Neurophysiology
Biophysics
Neuromicrobiology
Psychopharmacology
Psychiatric Social Work
Psychiatry
Health Education Clinical Psychology
Neurovirology
AAO
(DP&NR)
Neurosurgery
Child & Adolescent Psychiatry
Nursing Psychiatric & Neurological
Rehabilitation
Neuropathology
Neurology
Casualty
Medical
Officer
Speech Pathology
& Audiology
NI & IR
AAO
(OPD)
AAO
(Hospital)
Medical
Superintendent
Hospital Services
Resident
Medical Officer
Neuroanaesthesia
Neuro Sciences
Epidemiology
Behavioural
Sciences
Deans
Academics
Neurochemistry
Basic Sciences
Human
Genetics
AAO
AAO
AAO
AAO
(Stores) (Personnel) (Coordination) (Projects)
Administrative
Officer
Registrar
Administration
DIRECTOR / VICE-CHANCELLOR
Organogram
AAO
AAO
(Accounts) (Claims)
Accounts
Officer
DFA
FA & CAO
Finance &
Accounts
National Institute of Mental Health and Neuro Sciences
Internal
Audit
The members of the new Institute body during their first meeting on 5 February 2014
From the Director’s Desk........................................................................................................... 9
Awards, Honours and Key Assignments ............................................................................. 29
Visitors to NIMHANS................................................................................................................ 39
Patient Care Activities............................................................................................................... 45
Human Resource Development.............................................................................................. 64
Conference /Symposia/Workshops
I.
Scientific Programs Organised at NIMHANS ............................................................... 74
A. International.......................................................................................................... 74
B. National ................................................................................................................. 74
II. Scientific Programs Organised Outside NIMHANS...................................................... 83
A. International..........................................................................................................83
B. National .................................................................................................................83
III. Specific Training Underwent by Faculty / Staff.............................................................89
Central Facilities..........................................................................................................................91
Research Activities
Biophysics............................................................................................................................. 106
Biostatistics............................................................................................................................110
Child and Adolescent Psychiatry ...........................................................................................111
Clinical Neurosciences........................................................................................................... 113
Clinical Psychology................................................................................................................114
Epidemiology.........................................................................................................................133
Human Genetics ....................................................................................................................136
Neuroanaesthesia...................................................................................................................137
Neurochemistry......................................................................................................................139
Neuro Imaging and Interventional Radiology (NIIR)..........................................................146
Neurological Rehabilitation.................................................................................................. 148
Neurology...............................................................................................................................149
Neuromicrobiology................................................................................................................154
Neuropathology.....................................................................................................................154
Neurophysiology ...................................................................................................................161
Neurosurgery.........................................................................................................................177
Neurovirology........................................................................................................................179
Nursing ............................................................................................................................. 182
Psychiatry ..............................................................................................................................185
PsychiatricSocialWork ........................................................................................................195
Psychopharmacology ............................................................................................................197
SpeechPathologyandAudiology ........................................................................................ 198
Ayurveda ............................................................................................................................. 198
Publications
A. InternationalJournals ................................................................................................. 201
B. NationalJournals .........................................................................................................217
C. BookChapters/ConferenceProceedings..................................................................... 226
D. Monographs/Manuals/Reports .................................................................................. 233
E. Newsletters/Souvenirs ................................................................................................ 234
F. ArticlesforGeneralPublic/IECMaterials ................................................................ 235
G. BooksPublished .......................................................................................................... 237
Contributions to Scientific Deliberations
A. PresentationsinInternationalConferences ............................................................... 239
B. PresentationsinNationalConferences .......................................................................248
C. ResourcePersons ......................................................................................................... 277
D. Radio/TV/Phone-inProgrammes ...............................................................................282
Public Lectures .........................................................................................................................284
Statutory Bodies .......................................................................................................................288
Faculty and Staff ......................................................................................................................302
Finance and Accounts..............................................................................................................311
Homage
............................................................................................................................. 345
From The Director’s Desk
NIMHANS, as a multidisciplinary Institute in the field of mental
health and neurosciences, has three guiding principles±p atient care,
manpower development and research, and we have been following these with
commitment and passion. The Institute continues to figure prominently in
public discourse and policy advice at the national and international levels.
NIMHANS was declared an Institute of National Importance by an act
of Parliament. After Presidential assent, the NIMHANS bill was gazetted
in September 2012. The first Institute Body meeting was convened on 5
February 2014 and was presided over by Shri. Ghulam Nabi Azad, Hon’ble
Union Minister for Health and Family Welfare, Government of India.
With the formation of the Institute Body and other statutory committees,
NIMHANS is making sincere efforts to live up to the mandate given to
it. With high standards of clinical care, quality training and cutting-edge
research, NIMHANS is poised to deliver a more vibrant healthcare delivery
system in the years to come.
I am glad to present the Annual Report of NIMHANS and the audited
statement of accounts for the year 2013±2014.
Dr. P. Satish Chandra
Director/Vice-Chancellor
Annual Report
2013-14
1. PATIENT CARE SERVICES
NIMHANScontinuedtoprovidecomprehensivequalitypatient
care services, guided by knowledge and enabled by skill, in
thefieldsofmentalhealthandneurosciences.Duringtheyear
2013-14, nearly 4.7 lakh patients from various parts of the
countryandacrossthe globereceivedmedicalcare.
The patient care services primarily reach out to the needy
(Below Poverty Line) and under-privileged sections of our
society.Aboutthree-fourthsofthepatientswereprovidedwith
qualityservicesatnocostorathighlysubsidizedrate.Specialist
clinics and various rehabilitation services and programmes
were offered to render focused and targeted specialty care
duringtheyearunderreview.
Particulars
Screening
Registrations
Follow-ups
Admissions
Discharges
Casualty&EmergencyCare
Deaths
Extension Services*
Total
2012-13
1,01,816
54,850
2,08,978
15,397
13,877
28,368
720
27,394
436,803
2013-14
1,06,227
56,606
2,18,596
16,631
15,048
38,516
741
30,041
466,617
*= Gunjur – 2185, Gowribidanur – 5876, Maddur- 2937, Kanakapura- 2831, Madhugiri3431, Sakalawara- 12232, Turuvekere- 549
2. HUMAN RESOURCES DEVELOPMENT
2.1 Academic programmes
NIMHANS has always been known for its academic zeal,
innovations in training in the fields of mental health and
neuroscienceanditsresearchoutput.Duringtheyear,16medical
professionalscompletedPost-DoctoralFellowshipindifferent
specialities (Child & Adolescent Psychiatry-1, Acute Care
and Emergency Psychiatry-1, Addiction Medicine-3, Clinical
Neurosciences&TherapeuticsinSchizophrenia-1,Community
MentalHealth-1,ConsultationLiaisonPsychiatry-2,Obsessive
CompulsiveDisorder&RelatedDisorders-1,Neuroinfections-1,
Neurology
(Movement
Disorders)-1,
Neurological
Rehabilitation-2, Neuropathology-2), and 36 completed
PhD (Clinical Psychology-9, Neurochemistry-4, Neurological
Rehabilitation-1,
Neurophysiology-6,
Neurovirology-2,
Nursing-2, Psychiatric Social Work-8, Psychiatry-3, Speech
Pathology & Audiology-1); 160 candidates were declared
qualified to receive degrees in various specialties: DM
(Neurology),MCh(Neurosurgery),DM(Neuroradiology),MD/
Diploma(Psychiatry),MPhil,MSc,BScDegreesandDiplomain
Nursing.Atotalof3795studentsfromvariousotherinstitutes
- from India and abroad - visited NIMHANS and underwent
trainingduringtheyear.
Sl.
No.
Course
Postgraduate degree/diploma and
undergraduate
a) Joined the Institute during the year
2013-14
b) Completed and declared qualified
duringtheyear2013-14
Ph.D.
a) Joined the Institute during the year
2013-14
b) Completed and declared qualified
duringtheyear2013-14
Post-Doctoral Fellows
Short-term training (from outside
institutions)
Total No.
of
Students
247
160
42
36
16
3795
NIMHANS has signed a Memorandum of Understanding with
UniversityofLiverpoolfordualPh.Dprogramme.Tobeginwith,
acandidatefromtheUniversityofLiverpoolhasbeenselected
andregisteredunderthenewprogramme.Toincreasethepublic
healthcompetenciesofmedicalofficers,atwo-year‘Mastersin
PublicHealth’(MPH)hasbeenstartedfromtheacademicyear
2013-14andFellowshipinDisasterManagement&Psychosocial
Rehabilitation—a first of its kind in the country—has been
initiated,inwhicheightcandidatesfromalloverthecountrywill
betrainedeveryyear.
2.2 Capacity building and strengthening human
resource development
The mandate of NIMHANS is to catalyse, facilitate capacity
building and strengthen human resource development in
different health care delivery systems. NIMHANS is actively
committed to imparting advanced technical knowledge to
medical, para-medical and nursing professionals to promote
skills and evolve employable manpower to meet the needs of
thenation.Inadditiontotheshort-termtrainingprogrammes,
facultyandstaffatNIMHANSroutinelyparticipateinseminars,
workshops, conferences and other academic endeavours both
withinandoutsidetheInstitute.
During the year, NIMHANS hosted several international and
national scientific conferences. The faculty of the Institute
10 / National Institute of Mental Health and Neuro Sciences
Annual Report
organised 339 educational/ resourceful events (workshops
/ symposia / conferences: 212 at NIMHANS and 127 outside
the Institute). A total of 24 faculty members have undergone
focusedtrainingtoexpandtheirknowledgehorizon.NIMHANS
hosted various international and national scientific events
including7thCongressofAsianSocietyforChildandAdolescent
Psychiatry & Allied Professions and 12th Biennial Conference
ofIndianAssociationforChildandAdolescentMentalHealth
(27 September 2013), 3rd International Annual Conference
of the Society for Mitochondrial Research and Medicine-
MitochondriainHealthandMedicine(19-20December2013),
International Colloquium on Drug Resistant Epilepsy (16-18
August2013),MDS-sponsoredParkinson’sDiseaseEducation
Program 2014 on Understanding Parkinson’s Disease: From
Clinics to Basics (5-7 March 2014). The details of the other
scientific deliberations and conferences organised by the
Instituteareprovidedseparatelyintherespectivesection.
Several of the research initiatives at NIMHANS have been
inter-institutionalandmulti-disciplinaryinnature.Thethrust
areas of research continue to be: a) unraveling the molecular
and sub-cellular mechanisms for disease process, b) linking
clinicalstatuswithstructural,biochemical,immunologicaland
serologicalabnormalitiessearchingforbiomarkers,c)exploring
genetic basis for disease causation, d) developing prognostic
andclinicalpredictorsanddiagnosticinventory/checklists.
4. NEW INITIATIVES – NEW FACILITIES
4.1 Memorandum of Understanding (MoU)
1.
NIMHANSrenewedtheMemorandumofUnderstanding
with ‘Institute of Bioinformatics’, Bangalore, on 12 July
2013topromotejointresearchandacademicactivitiesin
theareasofmutualinterestbetweentheinstitutionsfora
furtherperiodofthreeyears.
2.
Led by Prof. P. Satish Chandra, Director/ViceChancellor, the NIMHANS team consisting of Dr. V.
Ravi, Registrar, Dr. Vivek Benegal, Prof of Psychiatry
andDr.AnitaDesai,Addl.Prof.ofNeurovirologyvisited
the University of Liverpool (3-7 September 2013) and
signed a Memorandum of Understanding for dual PhD
programme.
3.
The Memorandum of Understanding with Richmond
Fellowship Society (RFS) India has been renewed. Dr.
Kalyanasundaram, Chief Executive Officer, RFS - India
visited NIMHANS and signed the document on 15
October2013.
4.
TheDirectorofCBIandtheDIGvisitedNIMHANSand
signedaMOUwiththeInstituteon26November2013.
TheMOUenvisagesprovidingtrainingtothestaffofCBI
bytheDepartmentofClinicalPsychology,NIMHANSin
the process of interrogating the accused and witnesses
usingpsychologicalprinciples.
3. RESEARCH
Facilitatinghigh-qualityandtranslatableresearchandproviding
leadership for national policy have been the hallmarks of
NIMHANS.Duringtheyear2013-14,NIMHANSsteppedupits
researchactivitieswithvariousnewprojectsandinitiatives.A
totalof767scientificarticles/communicationswerepublished
(357articlesinInternationalJournals,216inNationalJournals,
and 194 other publications including monographs, manuals,
chaptersinbooks,articlesinnewspapers,etc.).
900
Other Publicaons
Naonal Journals
800
Internaonal Journals
700
600
566
534
500
457
214
400
300
142
626
582
118
119
203
197
199
227
2007-08
2008-09
2009-10
2010-11
216
183
200
100
194
208
194
164
117
767
174
191
248
Total
742
PUBLICATIONS
340
357
2012-13
2013-14
269
0
80
Total amount (INR crores)
70
2011-12
Amount Per annum (INR crores)
Total no. of projects
289
RESEARCH PROJECTS
60
30
128
57
0
32
93
48
42
200
199
136
137
20
10
300
250
50
40
350
115
150
69
60
100
9
10
10
14
16
21
26
07-08
08-09
09-10
10-11
11-12
12-13
13-14
25
50
0
2013-14
4.2 Enhanced Patient Care Services
1.
NIMHANShassuccessfullyimplementedacomprehensive
computerizedon-linee-HospitalSolutionincollaboration
with National Informatics Centre, Bangalore. Apart
from online activities (like ordering of investigations,
generation of laboratory reports, generation of case
summary,etc.),thee-Hospitalofferspatientregistration
andbillingmodules(integratedwithprescriptionmodule
National Institute of Mental Health and Neuro Sciences / 11
Annual Report
2013-14
on26December2013.Prof.P.SatishChandra,Director/
Vice-Chancellor,NIMHANS,inauguratedtheoutlet.This
outletisforsellingtheconsumablesusedinthevarious
DepartmentsofClinicalNeurosciences.Theoutletwould
provide these items at affordable price to the needy
patients.
andpharmacyoperations)makingitthefirstofitskindin
amedicalinstitutioninthepublicsector.
2.
3.
4.
The Department of Neurovirology and the Department
of Neurochemistry have successfully obtained the
NABL accreditation (ISO 15189) for the scope of their
variousdiagnosticservicesin2013.TheDepartmentsof
NeuromicrobiologyandNeuropathologyhavecompleted
theprocessofapplicationandassessmentbyNABLandare
awaitingaccreditation.Thisisasignificantachievement
forNIMHANSasthese aretheonlylaboratoriesamong
the other Institutes of National Importance to have
securedtheNABLaccreditation.
To cater to elderly CGHS beneficiaries with cognitive
deficits and for further evaluation and intervention,
NIMHANShasstartedascreeningprogrammeatthe10
CGHSWellnessCentresacrossBangalore.
New premises of the Department of Speech Pathology
& Audiology (approximately 9200 sq.ft. in area) was
inauguratedbyShri.S.K.Srivastav,AdditionalSecretary
and Financial Advisor, Ministry of Health & Family
Welfare, Government of India, on 20 June 2013. The
Department now has two sound-proof rooms for
audiometric evaluation and separate labs for Evoked
Potential,OtoacousticEmissionandImpedanceStudies.
Thisisinadditiontoindividualofficespaceforeachofthe
facultymembers.Thisfacilityhas14roomsforevaluation
and management services. Group-therapy Program for
stutterers has been initiated from 1 March 2014 and is
heldoneverySaturday(intheafternoon).
5.
A new ‘Step-Down Ward’ with 12 beds on the first floor
of Ashwini Block, NIMHANS was inaugurated by Dr.
Sharanaprakash R. Patil, Honourable Minister of State
for Medical Education, Govt. of Karnataka and VicePresident,NIMHANS,Bangalore,on8October2013.
6.
The Community Psychiatry Team started the TelePsychiatry/Tele-MedicineservicesalongwiththeCentral
Relief Committee (CRC), Bangalore from October 2013.
The CRC is primarily a protected shelter home for the
homeless people. With Tele-Psychiatry services, the
Community Psychiatry Team attends to about 20-25
patients/week. So far, about 250 patients have received
mentalhealthcarethroughthisportal.
7.
8.
Thestate-of-the-artMagneto-Encephalo-Graphy(MEG),
suppliedbyMs.ElectaofSweden,hasbeeninstalledand
isreadyforinauguration. Thisisthe firstofitskindin
thecountry,withaprovisionforco-registrationofMRI,
CT,PETScandataalongwithEEG/VideoEEGdataand
the MEG data. This would significantly facilitate the
comprehensiveepilepsysurgeryprogrammeandresearch
inNeuroPsychiatryatNIMHANS.
9.
To improve the quality of services to the patients,
the Department of Neuroimaging and Interventional
Radiology has acquired 16 Slice CT scanner GE Optima
540 and is being effectively utilised for increasing the
diagnostic throughput of the department. Molecular
imaging simultaneously with structural imaging is
being increasingly utilised for the diagnosis of various
neurologicalconditionsinitsearlystages.Thedepartment
in collaboration with Department of Neurosurgery is
involved in carrying out spinal injection procedures
for back ache and trigeminal rhizotomy procedures for
patientswithtrigeminalneuralgia.
10.
The Sakalwara Community Mental Health Centre
remodelled and renovated completely as ‘Centre for
Community Mental Health’ was inaugurated on 29
January 2014 by Ms. Sujaya Krishnan, Joint Secretary,
Ministry of Health and Family Welfare, Government of
India. The Centre has 22 cottages with kitchenette and
bathrooms,OPD,andtrainingandrehabilitationcentres
(wherechronicmentallyillpatientsandtheircaregivers
couldstayfor2-3months—prolongedstay—andundergo
rehabilitation).
11.
TheDepartmentofPsychiatricSocialWorkhasinitiated
individualandgroupservicesintheInfosysDharmasala
forthefamiliesofthepatientsadmittedtothehospital.
TheDepartmentcoordinatestheFreeLegalAidServices
for the Neurological, Neurosurgical and Psychiatric
patientsandtheirfamiliestoaddresstheirlegalproblems.
12.
Electric Drills, Portable CT, Leica OH5 Microscope
have been added to improve the intraoperative surgical
servicesoftheDepartmentofNeurosurgery.TheGamma
HLLLifeCareLtd(AGovt.ofIndiaEnterprise)opened
aretailoutletaboveJanathaBazaarintheOPDpremises
Annual Report
13.
Knifehasbeenre-loadedoftheCobaltsourcetofacilitate
treatmentofbraintumours.
19.
Automated Immunohematology Analyzer with high
throughput has been obtained for the Transfusion
MedicineCentreforrapidandaccurateBloodGrouping
andCrossMatchingofseveralsamplessimultaneously.A
newhigh-endHematologyAnalyzer(5partdifferential)is
beingintroducedwhichhashigherthroughputandgives
reliableautomateddifferentialWBCcountinadditionto
otherregularhematologicalparameters.AutomatedESR
testing, which avoids direct handling of infected blood
samplesandreduceshumanerror,hasalsobeenaddedto
theClinicalHaematologyFacility.
4.3 Outreach / Public Education and Extension
Activities / Awareness Programmes
14.
Real Time PCR machine has been installed in the
Department of Human Genetics, which helps in rapid
gene expression analysis, genotyping and HRM studies
forbothresearchanddiagnosisofgeneticdisorders.
15.
Hydrocollator Unit and Height Adjustable Couch have
beeninstalledatthePhysiotherapySection,andRobotic
Hand Rehabilitation equipment in the Occupational
TherapySectionoftheInstitute.
16.
Noninvasivecardiacoutputmonitors(NICOM)havebeen
installedatOTandICUtoevaluatethechangesinvarious
neurological disorders. Portable ultrasound machine is
being used in the operation theatre and neurointensive
care for diagnostic procedures especially central
venous cannulation, transthoracic echocardiography,
transcranial doppler, peripheral vascular doppler and
abdominal ultrasound. Heart rate variability (HRV)
monitors for autonomic nervous system are also being
used in the OT and ICU. Near infrared spectroscopy
(NIRS)forcerebraloxygenationisusedasamonitoring
device in carotid endarterectomy and other surgical
procedures.
17.
DigitalslidescannerhasbeeninstalledinHistopathology
sectionoftheDepartmentofNeuropathology.Thismajor
developmentwillfacilitatedigitizingthewholemicroscopic
slideandmakingitaccessibledigitallytoseveralusersin
far off places also. The intended use is for teaching and
trainingofpathologists,andforsharingofcasestudies.
18.
2013-14
AComputerlaboratorywith30computersystems,LAN
andinternetfacilityhasbeensetupattheDepartmentof
Biostatisticsduringtheyear.
Mother Dairy’s ‘Safal’ fruits and vegetable outlet was
inauguratedon21June2013.
1.
Centre for Public Health (CPH): One of the key
activitiesundertakenthisyearbytheCentreisthestartof
apublichealthobservatoryinKolardistrict(Government
of Karnataka circular ref:N.HFW30CGE2013 dated
30/1/2013) to field test public health approaches
and strategies for strengthening response to Mental,
Neurological, and Substance Use Disorders (MNSUDs),
Traumatic Injuries and other Non-Communicable
Diseases. A baseline assessment of health and human
resources for mental health, health management
informationsystems,mentalhealtheducationandhealth
caresystemsformanagementofMNSUDswasconducted
atKolarbytheCPHteam.Training,systemdevelopment
and health promotion initiatives are being developed to
integrate mental health components in various health
programmes. Further, the Karnataka State component
of the National Mental Health survey is being currently
undertakeninKolardistrict.
2.
NIMHANS Centre for Well-Being (NCWB):
‘TraumaRecoveryClinic’wasinauguratedon11December
2013 at NCWB, to provide brief psychological and social
interventions to adolescents (>16 years of age) and adult
survivors of psychological trauma through one-to-one
and/or group counseling and psychotherapy formats to
alleviatesymptomsandpavethewayforholistichealingand
psychologicalrecovery.Theclinichasbeenstartedtoprovide
a platform to enhance awareness about psychological
trauma, discuss its consequences and thus overcome the
trauma through effective strategies like workshops in
groups for subjects and caregivers. A workshop to teach
skillstoreduceburnoutandsecondarytraumaamongthe
counselorswasconductedaspartoftheclinicactivities.
Thecentrealsoinitiatedtwoothernewclinics:Awakeclinic
andSHUT(ServiceforHealthyUseofTechnology)clinic.
Awake clinic offers counseling and support to address
psychologicalproblems,particularlyrelatedtoabuseand
violenceathomefront.SHUTclinicprovidesscreeningfor
problematicusageoftechnologyandconductsawareness
and skill building and training workshops for counselors
attheCentreaswellasinthecommunity(school,colleges,
corporateoffices,etc).
Annual Report
3.
2013-14
Neuropathology Brain Museum:TheNeuropathology
Brain Museum (Human Brain Museum), the only one
of its kind in the country, is located in the Neurobiology
ResearchCentre.Thisuniquefacilityhasbecomeacentre
ofattractionforschoolandcollegestudents,servingasa
valuablesourceofNeuroscienceeducation.Thenumberof
visitors to the museum has increased significantly (3208
visitors)duringtheyear.
in the field of Mental Health and Neurosciences,
Department of Health Research (DHR and ICMR)
decidedtoestablishtheCentreforAdvancedResearch
for Innovation of Mental Health and Neurosciences
and it was inaugurated on 26th March 2014 by Dr.
V.M. Katoch, Director General of Indian Council of
MedicalResearch,NewDelhi.ThevisionoftheCentre
is “to be a leader in the field of mental health and
neuroscienceandevolvethestate-of-the-arttechnology
and innovation for translational research and develop
criticalmassofmanpowertomeetthenationalneedsby
scientific collaboration and co-operation”. The centre
has a dual component of manpower development to
achieveacriticalmassoftechnicalpersonnelandpropel
translationalresearchtotakescientificinvestigationto
thebedsidemedicine.
4.4 Academic
1.
To enhance the public health competencies of medical
officers,atwo-year‘MastersinPublicHealth’(MPH)has
beeninitiatedwithfiveseatsfromtheacademicyear201314.TheMPHcourseisconductedinaseriesofconcurrent
modules covering general public health concepts. During
thefirstyear,thetraineesgaincorecompetency,followed
byfocusedtrainingonMental,Neurological,andSubstance
UseDisorders(MNSUDs)andinjuriesinthesecondyear.
Attheendofthecourse,thecapacitytomanageMNSUDs
and accidental injuries from a public health perspective
will be strengthened, thus enhancing the availability of
trainedmanpowerintime.
2.
A one-month full time Certificate Course for
postgraduates of Clinical and Social Psychology
called “Positive Psychology Perspective: Research,
Education and Communication for Health” (P3Reach)
has been launched. It aims at strengthening skills in
conceptualizing and conducting research grounded in
positive psychological perspective and building capacity
tocarryouteducationalandcommunicationactivitiesfor
mental health promotion in the community. The course
announcementhasreceivedanenthusiasticresponseand
thefirstbatchwouldbecompletingthecourseinAugust
2014.
3.
A six-month certificate course in Cognitive Behavioural
Therapy (CBT) has been started, from December
2013. Three candidates have joined the course and are
undergoing training. The course is designed to equip
clinical psychologists with skills in the practice of CBT
usinghandsontrainingintheBehaviouralMedicineUnit
oftheDepartmentofClinicalPsychology.
Inauguration of Centre for Advanced Research for Innovation of Mental Health
and Neurosciences by Dr. V.M. Katoch, Director General of Indian Council of
Medical Research, New Delhi
2.
5. AWARDS AND RECOGNITIONS
5.1 Awards
1.
4.5 New Initiatives
1.
Complete automation of Library Circulation Services
(includingOPAC)andtherenovatedcirculationcounter
wasinauguratedbytheDirector,NIMHANSon3March
2014.Bar-codedlibrarymembershipcards(smartcards)
werealsoissuedontheoccasion.
In January 2011, realizing the leadership potential
shown and the rapid progress made by NIMHANS
Dr. Sailaxmi Gandhi, Assistant Professor of
Nursing, received the prestigious National
Florence Nightingale Award for the year 2014 from
the Hon’ble President of India at the Rashtrapati
Bhavan, New Delhi for meritorious service in the
field of nursing.
Annual Report
Dr. Sailaxmi Gandhi, Assistant Professor of Nursing, receiving the National
Florence Nightingale Award for the year 2014 from the Hon’ble President of
India Shri. Pranab Mukherjee
2.
Mrs. H. Dorothy Paripoornam, Staff Nurse,
received the State Florence Nightingale Award
from the Hon’ble Chief Minister of Karnataka at
Vidhana Soudha, Bangalore on the occasion of
Nurses Day 2014.
5.
Dr. T.R. Raju, Professor & Head of Neurophysiology,
received Fellowship Award at the Annual Meeting of
IndianAcademyofNeurosciences(IAN),Allahabad,2527October2013.
6.
Dr. G. Venkatasubramanian, Additional Professor of
Psychiatryreceived(a)VidyaSagarAward(byICMR)for
theyear2010,24September2013(b)ProfessorRaguram
Distinguished Young Teacher Award from the Indian
PsychiatricSociety(KarnatakaChapter)fortheyear2013.
7.
Dr.SriganeshK.,AssociateProfessor,Neuroanaesthesia
receivedBestMetroBranchAwardforIndianSocietyof
Anaesthesiologists(ISA),BangaloreattheISACON2013
(alsoelectedasSecretaryofISA,BangaloreBranch).
8.
Dr. Subasree R., Assistant Professor, Neurology received
YoungInvestigators/ScientistBursaryattheWorldCongress
ofNeurology,Vienna,Austria,21-26September2013.
9.
Dr. B.S. Shankaranarayana Rao, Additional Professor,
Neurophysiology, (i) Best Cited Paper: Dölen G,
Osterweil E, Shankaranarayana Rao BS, Smith GB,
AuerbachBDChattarjiSandBearMF(2007)Correction
of fragile X syndrome in mice. Neuron 56 (6):955-962.
(ii) Most popular article: Veena J, Shankaranarayana
Rao BS and Srikumar BN (2011) Regulation of adult
neurogenesisinthehippocampusbystress,acetylcholine
and dopamine. Journal of Natural Science, Biology and
Medicine. 2(1): 26-37. (iii) Most-read Paper. Hayashi
ML,ShankaranarayanaRaoBS,SeoJS,ChoiHS,Dolan
BM,ChoiSY,ChattarjiS,TonegawaS(2007).Inhibition
of p21-activated kinase rescues symptoms of fragile X
syndrome in mice. Proceedings of National Academy of
Sciences(USA)104(27):11489-94.
10.
Dr.MehulModi,M.Ch.,NeurosurgeryResident,received
the“BestPosterAward”,for“ValueofIndocyaninegreen
dyevideoangiographyinintracranialaneurysmsurgery–
Aperspectivefromatertiarymedicalcentreinadeveloping
country”, Neurovascon – 2013, Cerebrovascular Society
ofIndia,Hyderabad,September2013.
11.
Dr.PraveenkumarSaligoudar,SeniorResident,Department
of Neurosurgery, received The Best Paper Award in
Neurosurgery for “Cortical Reorganisation in Patients with
Cervical Spondylotic Myelopathy Following Surgery—
An fMRI Study”, at the 62nd Annual Conference of the
NeurologicalSocietyofIndia,Mumbai,12-15December2013
Mrs. H. Dorothy Paripoornam, Staff Nurse, receiving the State Florence
Nightingale Award from the Hon’ble Chief Minister of Karnataka Shri.
Siddaramaiah
3.
4.
Dr. P. Satish Chandra, Director/Vice-Chancellor,
NIMHANS, & Sr. Professor of Neurology received (a)
the Distinguished Alumnus of BMC Award, Bangalore
Medical College Alumnus Association, Bangalore, on 15
August2013(b)theprestigious‘BasantiDeviAmirChand
PrizeforBiomedicalScientistfortheyear2010’,during
theICMR(theIndianCouncilofMedicalResearch)held
inNewDelhi,24September2013.
Dr. V. Ravi, Registrar, NIMHANS, and Professor &
Head of Neurovirology received Excellence in Virology
AwardfromtheIndianVirologySocietyforoutstanding
contributions to Medical Virology at the Asia Pacific
CongressofVirologyheldatAmityUniversity,NewDelhi,
16-20December2013.
2013-14
Annual Report
12.
13.
2013-14
Dr. Raman Mohan Sharma, Senior Resident,
Department of Neurosurgery, received The Best
Poster Award for “Tubercular meningitis with
hydrocephalus with HIV co-infection –Role of CSF
diversion procedure” at the 62nd Annual Conference
of the Neurological Society of India, Mumbai, 12-15
December2013
Dr. Anisya Vasanth Memorial Oration
Dr. Giriraj Ratan Chandak, Principal Scientist and Group
Leader,CentreforCellularandMolecularBiology,Hyderabad,
deliveredDr.AnisyaVasanthMemorialOrationon11September
2013. The topic of the oration was “Journey from Simple to
Complex Genetic Disorders: Neuromuscular Disorders as
Model”.
Dr. H.S. Arun, PhD Scholar in Clinical Neurosciences,
Department of Neuropathology, received Herbet
Krause Award for the paper in Neuro-oncology titled
‘ImmunohistochemicalExpressionofNovelAstrocytoma
Moleculart Markers—Value in Aiding Histopathological
Grading and Prognosis’ at the 62nd Annual Conference
of the Neurological Society of India, Mumbai, 12-15
December2013.
5.2 Oration by NIMHANS Faculty
Dr.ShankarSK,EmeritusProfessorofNeuropathology,delivered
(i) Shobha Arjundas Oration, “Pathology of Epilepsy – Does it
giveakeytopathogenesis?”,ECON2014,Kolkata,February2014
(ii)TropicalNeurologyOration,“BiologyofNeurocysticercosis”,
Tropicon2014,Chennai,March2014.
6. ACTIVITIES AND EVENTS AT NIMHANS
6.1 Orations
Dr. D.N. Prasad Oration
Dr.D.N.PrasadOrationwasdeliveredbyProf.SubrataSinha,
Director, National Brain Research Centre (NBRC), Manesar,
Gurgaon, on 20 April 2013 at NIMHANS. The topic of the
orationwas“InflammationandGlioma:ANewLink”.
Dr. Giriraj Ratan Chandak, Principal Scientist and Group Leader, Centre for
Cellular and Molecular Biology, Hyderabad being felicitated after delivering Dr.
Anisya Vasanth Memorial Oration
Dr. Ramachandra N Moorthy Oration 2014
The 11th Dr. Ramachandra N Moorthy Oration 2014 was
heldon9January2014.TheOrationon“MentalHealthfor
Changing India” was delivered by Professor R. Srinivasa
Murthy, Patron Member, Association for the Mentally
Challenged (AMC), Ex Dean & Head Department of
PsychiatryNIMHANS.
6.2 Events
World Parkinson’s Day
TheDepartmentsofNeurologyandNeurosurgery,NIMHANS
in collaboration with the Parkinsons Disease Society
of Karnataka organised a programme for patients with
Parkinson’s disease to commemorate the World Parkinson’s
Dayon7April2013.
Prof. Subrata Sinha, Director, National Brain Research Centre (NBRC), Gurgaon
delivered Dr. D.N. Prasad Oration
Topics covering various aspects of Parkinson’s disease—
medical,surgicalandneuro-rehabilitation—werediscussedat
the event. A panel of experts answered individual questions
fromtheaudienceonaone-to-onebasisaftertheprogramme.
Annual Report
2013-14
World Parkinson’s Day
International Nurses Day 2013 celebrations
Dr. B.R. Ambedkar Jayanti
BharatRatnaDr.B.R.AmbedkarJayantiwascelebratedon23
April2013atNIMHANS.
Dr. Mudnakudu Chinnaswamy, noted litterateur and Chief
AccountsOfficer-cum-FinancialAdvisor,BMTC,wasthechief
guest. Venerable Bhante Vinayarakhita Thero, Vipassana
Acharya, Chief Abbot, Spoorthi Dhama Vihara, Bangalore,
wastheGuestofHonour.Buddhavandana,Yakshaganadance
performancebyatroupefromKarnatakaKalakshetra,andskits
on untouchability, right to education and domestic violence
markedDr.Ambedkar’s122ndbirthanniversarycelebrations.
Awards for Best Staff Nurse and Best Wards (Psychiatric and
Neuro Centre) were presented on the occasion. Staff nurses
Smt.AVimalaMonicaandSri.PrasannaKumarGfromStroke
Ward&CentreforAddictionMedicinebaggedtheBestNurses
Awardfor2012-13.TheBestWardAwardwassecuredbyPV.III
andEICU.BestNurseAwardinstitutedbyC.KrishnaiahChetty
&SonsFoundation,BangalorewasgiventoMrs.M.R.Bhanu,
StaffNurseatCasualty.Mrs.FloraThangam,WardSupervisor,
whoreceivedtheprestigiousFlorenceNightingaleAwardfrom
the President of India Shri. Pranabh Mukherjee, was also
honoured.
SPICMACAY – NIMHANS - Santoor Recital
SPICMACAY-NIMHANSchapterinassociationwithNIMHANS
Gymkhana organised a santoor recital by Padma Vibhushan
Pandit Shivkumar Sharma at NIMHANS Convention Centre
on22July2013.Theaudiencewereenthralledandtreatedto
the best of santoor performance at the 90-minute concert by
the maestro. Pandit Shivkumar Sharma was accompanied by
Shri. Ramkumar Mishra on the tabla and Shri Takahiro Arai
ontanpura.
Dr. B.R. Ambedkar’s 122nd birth anniversary celebrations
International Nurses Day 2013
TheInternationalNursesDaywascelebratedon15May2013
under the theme “Closing the Gap: Millennium Development
Goals—CountdownStarts”.
Dr.A.Chandramukhi,formerProfessor&Head,Departmentof
Neuromicrobiology,NIMHANSwastheChiefGuest.
Santoor exponent Pandit Shivkumar Sharma performing at a concert organised
by SPICMACAY-NIMHANS chapter
Annual Report
2013-14
Independence Day
Colourful cultural programmes marked Independence Day celebrations
Independence Day was celebrated with patriotic fervour at
NIMHANS on 15 August 2013. The unfurling of the National
Flag by Dr. P. Satish Chandra, Director/Vice-Chancellor was
followed by colourful cultural programmes by the students of
NIMHANSCollegeofNursingandinmatesofvariouswardsof
thehospital.
Teacher’s Day
Teacher’sDaywascelebratedon10September2013.Keeping
with the Teacher’s Day tradition, senior faculty members of
NIMHANSwerehonouredfortheirsignificantachievementsin
their respective specializations and outstanding contributions
tothegrowthoftheInstitute.
TheChiefGuestofthefunction,Dr.B.V.Subbarayappa,former
president, International Union of History and Philosophy of
Science (an affiliate of UNESCO) delivered a special talk on
‘Science, Spirituality and Humanism: The Vital Tripod for
SustainableCivilisation’.
Dr. Sharanprakash R. Patil, Hon’ble Minister of State for Medical Education,
Government of Karnataka releasing mental health awareness and educational
materials at an event organised to celebrate World Mental Health Day
Dr. Sharanprakash R. Patil, Hon’ble Minister of State for
Medical Education, Government of Karnataka was the Chief
Guest. The minister, in his special address, highlighted the
importanceoflookingatthementalhealthissuesexperienced
byseniorcitizensintheircommunitiesandprovidingnecessary
support and services. He released various mental health
awareness and educational materials. Prof. Srikala Bharath,
DepartmentofPsychiatryandConsultant–GeriatricClinic&
Services,NIMHANSpresentedthereportofvariousactivities
conductedbythemultidisciplinaryteamoftheGeriatricClinic
toaddressmentalhealthissuesintheelderly.
Vigilance Awareness Week
The Vigilance Awareness Week was observed by NIMHANS
under the theme “ Promoting Good Governance—Positive
ContributionofVigilance”from28October2013to2November
2013. Valedictory function of the week-long programme was
heldon4November2013.
Teacher’s Day celebrations
World Mental Health Day
WorldMentalHealthDaycelebration,underthetheme“Mental
HealthandOlderAdults”,washeldon8October2013.
Shri. P.S. Rajagopal, Senior Advocate, Karnataka High Court, at the valedictory
function of the Vigilance Awareness Week
Annual Report
2013-14
AspartoftheVigilanceAwarenessWeek,NIMHANSorganised
variousactivitiesincludingworkshopsanddisplayofbanners
andpostersatprimelocationsintheInstitute.
Shri. P.S Rajagopal, Senior Advocate, Karnataka High Court,
wasthechiefguestattheevent.
Prof. V. Ravi, Registrar, NIMHANS, administered pledge
to the faculty and staff of NIMHANS for eradication of
corruption in accordance with the instructions of the
GovernmentofIndia.
Children’s Day
Schoolchildren at the exhibition held as part of the National Epilepsy Day
celebrations
Karnataka Rajyotsava
Children’s Day was celebrated with enthusiasm by the
DepartmentofChildandAdolescentPsychiatryon13November
2013.Variousculturaleventswereheldinwhichchildrenfrom
Psychiatrywardshowcasedtheirtalent.
Kannada Rajyotsava was celebrated with great zeal on
30 November 2013. Noted poet and humourist Shri. H
Dundiraj, was the Chief Guest. He enthralled the audience
withhismeaningfulhumourandcaptivatingspeech.Cultural
programmeattheeventturnedouttobeaspellbindingshow
withthelightmusicbyVinay,SupriyaAcharyaandteam.The
eventgeneratedasenseofprideinthemindsoftheaudience
forbeingapartofaculturethatissorichandvibrant.
Children’s Day celebrations
NIMHANS Gymkhana celebrated Children’s Day on 14
November2013.Prizestothewinnersofvariouscompetitions
held as part of the Children’s Day celebrations were handed
over by Prof. P. Satish Chandra, Director/Vice-Chancellor,
NIMHANS and Prof. V. Ravi, Registrar, NIMHANS on the
occasion.
National Epilepsy Day
Noted poet and humourist Shri. H. Dundiraj at Karnataka Rajyotsava celebrations.
NIMHANS in association with Indian Epilepsy Association
(IEA), Bangalore Chapter jointly organised Epilepsy Day
celebrationson16-17November2013attheNIMHANSCollege
ofNursing.
Lamp Lighting Ceremony
Dr.V.B.Patil,Commissioner,DepartmentofHealthandFamily
Welfare,GovernmentofKarnatakawastheChiefGuest.Mr.S.
Venkateshwar,AdditionalDirectorGeneral,PressInformation
BureauwastheGuestofHonour.Morethan700studentsfrom
various schools visited the exhibition held to raise awareness
aboutepilepsy.
The College of Nursing, NIMHANS, celebrated its 8th Lamp
Lighting Ceremony on 4 December 2013. Shri. CK Mishra,
Additional Secretary, Ministry of Health & Family Welfare,
Government of India was the Chief Guest. Dr. K Reddemma,
former dean and HoD, Nursing, NIMHANS was the Guest of
Honour.MeritoriousstudentsreceivedawardsfromtheChief
Guestandotherdignitaries.Studentsandtraineeslitthelamp
symbolisingtheirdedicationtotheprofession,andtookanoath
toservehumanitywithcompassionandempathy.
Annual Report
2013-14
AposterexhibitiontomarktheobservanceofWorldAIDSDay
wasalsoorganisedontheoccasion.
Prof.P.SatishChandra,Director/Vice-Chancellor,NIMHANS,
presented a detailed report highlighting the various
developmentsandachievementsoftheInstituteduringthepast
year.
Institute Day Celebrations
Shri. C.K. Mishra, Additional Secretary, Ministry of Health & Family Welfare,
Government of India at the 8th Lamp Lighting Ceremony
NIMHANS celebrated its 40th Institute Day, the first after
securingthestatusofanInstituteofNationalImportance(INI)
on 14 February, 2014. The Chief Guest for the event was Mr.
Nandan Nilekani, Chairman, Unique Identification Authority
ofIndia[UIDAI],PlanningCommission,GovernmentofIndia.
Director P. Satish Chandra announced on the occasion the
launchofonlineregistrationserviceswiththeaimofreducing
thewaitingtimeforout-patientsontheoccasion.
Republic Day
The65thRepublicDaywascelebratedwithgaietyandfervour
on 26 January 2014. Flag hoisting by the Director/ViceChancellor, NIMHANS was followed by colourful cultural
eventsandprizedistribution.
18th Convocation of NIMHANS
Mr. Nandan Nilekani, Chairman, Unique Identification Authority of India
[UIDAI], Planning Commission, Government of India at the 40th Institute Day
celebrations
7. INFRASTRUCTURE/BUILDINGS
Shri. Ghulam Nabi Azad, Honourable Union Minister for Health & Family
Welfare, Government of India and Mrs. Kiran Mazumdar Shaw, Chairman &
Managing Director, Biocon Limited, Bangalore and Dr. Sharanprakash R. Patil,
Hon’ble Minister of State for Medical Education, Government of Karnataka at
the 18th Convocation of NIMHANS
1.
Existing Nursing Student Hostel and Cauvery Ladies
Hostel have been expanded by adding one more floor
to accommodate the increased intake of nurses and
postgraduatestudents.
2.
Livinguptothephilosophyofagreenenvironmentand
conservationofwater,treatedandpurifiedwaterfromthe
sewageplantisbeingprovidedtothehostelsforflushing
toilets apart from using it for gardening. Similarly, a
one-tonbiodegradableorganicwasteconverterhasbeen
installedintheInstitutetohandlealltheorganicwaste,
excluding biomedical waste, to convert it in to compost
manureforgardeningpurposes.
3.
Old heritage building earlier named as ‘Children’s
Pavilion’ in 1940’s has been modified retaining its
The18thConvocationofNIMHANSwasheldon5February2013
at the Convention Centre of the Institute. Shri. Ghulam Nabi
Azad,HonourableUnionMinisterforHealth&familyWelfare,
Government of India and President, NIMHANS declared the
convocationopenandaddressedthegathering.
ChiefGuestMrs.KiranMazumdarShaw,Chairman&Managing
Director,BioconLimited,Bangalore,deliveredtheconvocation
address.
Annual Report
heritage architecture to house the NIMHANS History
Museum on the ground floor. First floor of the same
buildingwouldhousea‘ScienceGallery’onmentalhealth
and neurosciences to create awareness among school
and college students and general public. The interior of
this building has been remodeled to depict the history
andevolutionofNIMHANSfromtheMentalAsylumof
1868 under the British,to the present day NIMHANS.
Thebuildingwillbeinauguratedandthrownopentothe
public,thenextyear.
4.
AnofficeforthePresidentoftheInstituteBodyhasbeen
constructed with a scenic view of eucalyptus trees. This
spacewillalsobeusedforvideoconferencingwhenever
itisavailable
5.
BhoomiPoojafortheconstructionofthenewAdolescent
PsychiatryBlockwasperformedon17February2014.
2013-14
8.2 Government of India Reservation Policy
NIMHANSfunctionsundertheMinistryofHealthandFamily
Welfare,GovernmentofIndiaandfollowsthereservationpolicy
aslaiddownbytheCentralGovernmentforfacultyrecruitment
andstudentadmission.
8.3
Persons with Disabilities Act
Reservation to Persons with Disabilities is provided by
NIMHANS in line with the provisions of the Persons with
Disabilities (Equal Opportunities, Protection of Rights and
Full Participation) Act, 1995 in various posts and services of
the Institute. NIMHANS is also involved in various activities
initiated to remedy the exclusion of persons with disabilities
byfocusingonpromotingtheaccessibility,aswellasremoving
differenttypesofbarriersintheInstitute.
8.4 Official Language Policy
8. POLICY IMPLEMENTATION
8.1 Implementation of Right to Information Act
NIMHANS has implemented the Right to Information Act
2005 as per the directions of Central Information Commission,
Government of India, and the Ministry of Health and Family
Welfare, Government of India. A team of Central Public
Information Officers headed by the Registrar of the Institute—
who is the Appellate Authority—is responsible for providing
information to a person who seeks information under the RTI
Act. The Public Relations Officer serves as the liaison officer
andhandlescorrespondencewiththeauthoritiesconcerned.On
average,theInstitutereceives15-20RTIapplications,andreplies
tothequeriesaresentwithinthestipulatedtime.Quarterlyreturns
pertainingtoRTIarefiledandsubmittedtoCentralInformation
Commissiononlineaspertheprescribedguidelines.
The Official Language Implementation policies and
Constitutionalprovisions(OfficialLanguagesAct,1963andthe
OfficialLanguagesRule,1976)arebeingstrictlyimplemented
atNIMHANSundertheguidanceoftheDepartmentofOfficial
Language, Union Ministry of Health and Family Welfare,
Government of India. Advertisements, notifications, name
boards, and sign boards are in Hindi and English. Hindi
courses/classes, Hindi typing and stenography training are
offeredregularly.
8.5 Results Framework Document
NIMHANS received excellent rating from the Union Ministry
ofHealthandFamilyWelfare,GovernmentofIndiafortimely
submission of the Results Framework Document (RFD).
NIMHANSisthefirstmedicalinstitutiontodrafttheRFD.
Annual Report
2013-14
NIMHANS
The way forward...
F
ollowing the declaration of our National Institute
of Mental Health and Neurosciences (NIMHANS)
as an ‘Institute of National Importance’, the institute
has moved one more step forward with the gazette
notification on 29th November 2013, by the Ministry
of Health and Family Welfare. Various administrative
and academic bodies have been constituted and thus
completing the procedure for the parliamentary act
implementation.
NIMHANS has made a name for excellent patient
care and uncompromising academic standards and is
looked up to be a trend setter in all domains.To facilitate
efficient and advanced diagnostic facilities, a new and
state-of-the-art Digital Subtraction Angiographic
facility has been commissioned. The construction work
for establishing a synchronous, state-of-the-art PETMRI facility along with a cyclotron to develop much
needed ultra short acting radio-pharmaceuticals for
the PET has been going on in full swing. We expect
the PET-MRI to be ready by March 2015. Once
commissioned, NIMHANS will be able to collaborate
and share the materials and technology with the sister
institutions in the state and thus evolve a network with
the hospitals for patient care.
A new and relatively comprehensive
Subspecialty Block for Neurosciences is envisaged
and planned next to the Neuro Centre of the
Institute with 125 hospital beds, special diagnostic
facilities and two OTs along with Helipad. Expected
to be operational in the later part of 2015 or early
2016, this optimises the use of facilities by proximity
and planned logistics.
In the field of Academics, NIMHANS has
planned to start two super speciality courses, DM in
Neuropathology and DM in Addiction Medicine, from
the next academic year.These new and specialised courses
will augment the manpower of pre-existing Post Doctoral
Fellows in various subspecialties in both clinical and
preclinical branches and develop highly trained medical
specialists for the country. Our Institute has extended
the MOU with Maastricht University, Netherland and
University of Liverpool (UK) for exchange of scientific
knowledge and pursuit of Dual PhD courses for medical
graduates and non-medical students. We are actively
pursuing the process of networking with various other
foreign universities across the globe in the field of Mental
Health and Neurosciences.
Recognising the leadership shown by
NIMHANS, Department of Health Research
(DHR-ICMR) has established the ‘Centre for
Advanced Research’ for innovations in Mental Health
and Neurosciences: Manpower Development and
Translational Research. This was inaugurated on 26th
March 2014. NIMHANS has been given the onerous
responsibility to plan and conduct a National Mental
Health Survey to arrive at a nationally representative
estimate of mental health problems in the country.
The pilot study has been completed in the district of
Kolar, Karnataka, at the Public Health Observatory of
the Centre for Public Health at NIMHANS. These
estimates,the first of its kind in post-independent India,
will guide in better implementation of the National
Mental health programme (NMHP) and the District
Mental Health programme. The Centre for Public
Health (CPH) will continue to play a prominent role
in policy planning for the government in the field of
mental health with special emphasis on substance
use disorders, neuro trauma and non-communicable
diseases, which is the need of the hour. The unique
and proactive initiative with long-term implications
to the affected and their family is the ‘Trauma
Recovery Clinic’ at the NIMHANS Centre for Well
Being (NCWB) which provides psychotherapy and
counselling, facilitating holistic healing. In addition,
the NCWB has started two special clinics relevant to
Annual Report
the present day social problems like violence and abuse
of women and a SHUT Clinic (Service for Healthy
Use of Technology). SHUT Clinic is envisaged to
moderate the use or avoid addiction to the present
day gadgets and technology. All these issues addressed
by NIMHANS have futuristic implications in social
psychology and mental health as advocated by the
Government of India.
The construction work of the ‘Northern
Campus of NIMHANS’, located at the junction of
three highways to establish a state-of-the-art ‘Poly
Trauma Centre’ with ‘air ambulance’ facility to lift
the injured is going to be initiated shortly.
2013-14
NIMHANS has moved forward with its
declared vision in sight and mission in mind, to
actively serve the people, enhance public awareness
about preventable social and medical maladies and
pursue translational research. We are prioritising
the areas to be addressed and striving to achieve the
stated goals within the stipulated timelines. Let us
develop a human network involving the public, the
technocrats and politicians with mutual respect, in
our vision for a brighter, pragmatic tomorrow.
Come let us all join hands and work together for this
glorious institute and our country.
Prof. P. Satish Chandra
Director/Vice-Chancellor, NIMHANS
EXPRESS-ION: A piece of artwork made by a child for a drawing competition organised by the Department of
Psychiatric Rehabilitation Services.
Annual Report
Smt. P Chandra
AAO
DOJ:04.10.1980
DOR:30-04-2013
(VRS)
2013-14
Sri. Nataraja A
PhotoCopying
Operator
DOJ:15.03.1979
DOR:30-04-2013
Smt. BV Geetha Devi
WardSupervisor
DOJ:06.09.1979
DOR:31-05-2013
Sri. C Sathya Prasad
Manager
DOJ:18.12.1981
DOR:31-05-2013
Sri. Perumal M
MultiTaskingStaff
DOJ:20.02.1989
DOR:31-05-2013
Staff who served
NIMHANS
(Retired / Superannuated)
Sri. Danial Y
HospitalAssistant
DOJ:16.02.1983
DOR:31-05-2013
Dr. KV Kishore
Kumar
Psychiatrist
(SpecialGrade)
DOJ:21.10.1986
DOR:06-05-2013
(VRS)
Ms. Kantha
Manager
DOJ:25.09.1982
DOR:05-06-2013
(VRS)
Smt. Ramanamma
HospitalAssistant
DOJ:30.11.1983
DOR:06-06-2013
(VRS)
Dr. K Reddemma
Sr.Prof.ofNursing
DOJ:11.04.1974
DOR:30-06-2013
Dr. CR Chandrashekar
Sr.Prof.ofPsychiatry
DOJ:01.08.1979
DOR:30-06-2013
DOJ:DateofJoining,DOR:DateofRetirement
24 / National Institute of Mental Health
and Neuro Sciences
Sri. Shambappa S
OfficeAssistant
DOJ:15.03.1979
DOR:30-06-2013
Annual Report
Sri. Hanumanthappa
MultiTaskingStaff
DOJ:21.02.1989
DOR:30-06-2013
Sri. Jayaramu TM
OfficeAssistant
DOJ:29.05.1986
DOR:30-06-2013
Dr. HS Siddamallaiah
PL&IO
DOJ:15.02.1985
DOR:31-07-2013
Smt. Jayalakshmi
HospitalAssistant
DOJ:17.12.1981
DOR:31-07-2013
Sri. Loghanathan R
HospitalAssistant
DOJ:12.02.1982
DOR:30-06-2013
Smt. Rangamma H
HospitalAssistant
DOJ:21.11.1980
DOR:31-07-2013
Dr. TS Devaragudi
Addl.Prof.of
Neuroanaesthesia
DOJ:08.10.1997
DOR:01.08.2013
(VRS)
Smt. Sharada Vasudev
Hervatta
StaffNurse
DOJ:01.06.1983
DOR:31-08-2013
Smt. SD Joy Chandra
Manager
DOJ:02.05.1984
DOR:31-08-2013
2013-14
Sri. SP Meshram
Sr.OccupationalTherapist
DOJ:26.02.1979
DOR:31.08.2013
Sri. V Shekar
Manager
DOJ:06.10.1982
DOR:31-08-2013
Sri. Gopinath Prabhu
UDC
DOJ:16.09.1994
DOR:31-08-2013
Sri. Kempanna KV
HospitalAssistant
DOJ:01.02.1982
DOR:31-08-2013
Annual Report
2013-14
Smt. Natarajan V
OfficeAssistant
DOJ:10.10.1983
DOR:31-08-2013
Sri. KN Vishwanath
AAO
DOJ:07.11.1979
DOR:30-09-2013
Smt. Yeshodha
HospitalAssistant
DOJ:28.10.1980
DOR:30-09-2013
Sri. Narasimhaiah N
HospitalAssistant
DOJ:15.03.1979
DOR:31-10-2013
Smt. G Vanaja Devi
Manager
DOJ:29.08.1985
DOR:31-10-2013
Sri. OS Santhosh
InstructorGr–I
DOJ:12.09.1980
DOR:30-11-2013
Dr. Nagarajaiah
Addl.Prof.ofNursing
DOJ:06.09.1976
DOR:30-11-2013
Sri. Hemanna
HospitalAssistant
DOJ:10.10.1983
DOR:31-10-2013
Smt. Sampath Kumari A
HospitalAssistant
DOJ:11.01.1982
DOR:30-11-2013
Sri. M A Irudaya Raj
Asst.Inst,(Fitter)
DOJ:21.05.1982
DOR:30-11-2013
Smt. Sampathkumari G
HospitalAssistant
DOJ:25.03.1982
DOR:30-11-2013
Smt. Lakshmamma B
HospitalAssistant
DOJ:05.11.1980
DOR:31-12-2013
Sri. Chandran G
HospitalAssistant
DOJ:27.07.1981
DOR:31-12-2013
Annual Report
Dr. M Venkataswamy
Reddy
Addl.Prof.ofBiostatistics
DOJ:15.03.1973
DOR:31-01-2014
Sri. HC Venkateshaiah
AAO
DOJ:12.03.1979
DOR:31-01-2014
Sri. Suryanarayana
UDC
DOJ:22.01.1982
DOR:31-01-2014
Smt. SR Suvarna Bai
AAO
DOJ:21.01.1974
DOR:28-02-2014
Sri. K Mannulingam
Manager
DOJ:15.03.1979
DOR:31-01-2014
Smt. Shanthamma
HospitalAssistant
DOJ:13.07.1981
DOR:31-01-2014
Sri. R Chandrashekar
Manager
DOJ:29.09.1982
DOR:28-02-2014
Sri. JS Xavier
Manager
DOJ:08.04.1983
DOR:28-02-2014
Sri. Venkataramana
OfficeAssistant
DOJ:22.09.1981
DOR:28-02-2014
Sri. Lakshmana N
OfficeAssistant
DOJ:31.10.1983
DOR:28-02-2014
2013-14
Sri. Paneer Selvam V
HospitalAssistant
DOJ:05.10.1983
DOR:28-02-2014
Smt. Velliamma
HospitalAssistant
DOJ:22.03.1989
DOR:28-02-2014
Smt. VA Rani
Manager
DOJ:29.01.1981
DOR:31-03-2014
Annual Report
2013-14
Research Collaborations
National
International
Lifting The
Burden
in Official Relation with the
World Health Organization
The Global Campaign against
Headache
Awards, Honours and
Annual Report
2013-14
Key Assignments
Biophysics
Dr. Preeti Joshi, Professor & Head, Member, Department of
BiotechnologyTaskforceonNeuroscience.
Child&LawNLSIU,Delhi,UNICEFandNationalCommission
for protection of right as of the child (iii) Secretary General,
RichmondFellowship,NationalBoard(iv)Chairperson,House
CommitteeandAdmissionCommittee,AshaHouseRichmond
Fellowship,Bangalore.
Biostatistics
Dr.DK Subbakrishna,Professor & Head (i) President,Indian
Society for Medical Statistics (ii) Member, Executive Council,
InternationalBiometricSocietyIndianRegion.
Dr. K Thennarasu, Professor, Member, Executive Council,
IndianSocietyforMedicalStatistics.
Dr. P Marimuthu, Additional Professor, General Secretary,
InternationalBiometricSocietyIndianRegion.
Child and Adolescent Psychiatry
Dr. Satish Chandra Girimaji, Professor & Head, Member,
NationalTrusttaskgrouponearlyinterventioninautism.
Dr.ShobaSrinath,Professor,(i)Member(a)GoverningCouncil,
Dr.SRCInstituteofSpeechandHearing,Bangalore,14August
2013 (ii) Temporary Advisor, WHO Consultation on Autism
Spectrum Disorders and other Development Disorders: From
awareness raising to capacity building, Geneva, Switzerland,
16-18September.
Dr.ShekharSeshadri,Professor,(i)Member(a)Committeeto
draft sexual assault assessment protocol, Ministry of Health
& Family Welfare, Govt. of India (b) Technical Resource
Group, NUHM, Ministry of Health & Family Welfare, Govt.
of India (c) UGC Committee against ragging (d) Advisory
Boardonemotionalsafetyatschools,TeachersFoundation(e)
ManagementCommitteeRichmondFellowship-PGCollege(f)
Governing Council, Richmond Fellowship Bangalore Branch
(g) Adoption Recommendation Committee, Department
of Women and Child Development, Govt. of Karnataka (h)
Working Group on Railway Children, National Commission
for Protection of Child Rights (i) Selection Panel for Juvenile
JusticeBoard,DepartmentofWomenandChildDevelopment,
Govt. of Karnataka (j) Board of Directors, Christel House
Learning Centre, Bangalore (k) Advisory Board, Cambridge
School,HSRLayout,Bangalore(l)AdvisoryBoard,RAHIDelhi
(ii)Invitee,NationalconsultationonJuvenileJusticeCentrefor
Dr.JohnVijaySagar,AssociateProfessor,(i)AssociateEditor
of Frontiers in Child and Neurodevelopmental Psychiatry
(ii) Member, Editorial Board, Andhra Pradesh Journal of
PsychologicalMedicine(APJPsycholMed).
Clinical Neurosciences
Dr.VikasDhiman,PhDScholar(i)received(a)ICGEBAward
to attend 2nd Post EURASNET symposium on Alternate
RNA splicing, Trieste, Italy, 18-20 November 2013 (b) ILAE
Educational Bursary Award to attend online VIREPA course
on Genetics of Epilepsy, October 2013 - April 2014 (c) ICMR
Travel Award to attend 30th International Epilepsy Congress,
Montréal,Canada,23-27June2013(ii)selectedastheStudent
Ambassador of International Journal of Medical Students
(IJMS)fortheAsia-Pacificregion.
Dr.AshokMunivenkatappa,PhDScholar,received(i)Travel
Grant Scholarship, Council of Scientific and Industrial
Research (CSIR), July 2013 (ii) Travel Grant Award, World
FederationofNeurosurgicalSocieties(WFNS)TrustofIndia
(iii) Travel Award, International Neuro Trauma Society
(INTS)2014.
Dr. Ketaki Swapnil Bhalsing, PhD Scholar, received Travel
Grant for 17th International Congress on Parkinson’s Disease
andMovementdisorders,MovementDisorderSociety(MDS).
Dr. Shivkumar, PhD Scholar, received Travel Grant to attend
SIRS 2014, Schizophrenia International Research Society,
Florence,Italy,5-9April2014.
Dr. Rakesh Balachandar, PhD Scholar, received International
Travel Award from Department of Bio-Technology to attend
28th International Conference of Alzheimer’s Disease, 18-20
April2013.
Dr. Velmurugan J, PhD Scholar, received International
Federation of Clinical Neurophysiology (IFCN) Award and
Fellowship-2014.
Annual Report
2013-14
Clinical Psychology
Dr.AnishaShah,Professor&Head,(i)NationalBoardMember,
RichmondFellowshipSocietyofIndia(ii)Inviteddiscussantfor
biannualseminaronmaritalargumentsandchallengesofdual
career Institute of Social and Economic Change, Bangalore,
July2013(iii)EditorialBoardMember,InternationalJournal
of Applied Psychology and Psychotherapy February 2014 (iv)
Mentor, International Family Therapy Association Training
Division(SkypePals)January2014.
Dr. Uma Hirisave, Professor, (i) Guest Editor, International
JournalofPsychologicalStudies(ii)Member(a)Rehabilitation
Council of India (b) BOS of NIMH, Secunderabad (c) BOS,
Dept. of Psychology, Kuvempu University, Shimoga (d) BOS,
Dept. of Psychology, JN College, Bangalore (iii) Honorary
Consultant-IMRC(JHMRC).
Dr. MP Sharma, Professor, Hon. President, Karnataka
AssociationofClinicalPsychologists.
Dr. LN Suman, Professor, (i) Coordinator for developing and
implementing a training programme for CBI Investigating
Officers(IOs)on‘ScientificInterviewingMethods’(ii)Honorary
Consultant, ‘Abalashrama’, a home for destitute women (iii)
Member (a) House Committee of ‘Asha House’, a RFS halfwayhomeforchronicpsychiatricpatients(b)EditorialBoard,
International Journal of Biosciences and Technology (iv)
Reviewer (a) Journal of Addictive Behaviors, Therapy and
Rehabilitation(b)InternationalResearchJournalofPublicand
EnvironmentalHealth.
Dr. Seema Mehrotra, Additional Professor, (i) Reviewer for
International and national journals: Journal of Community
and Applied Social Psychology, Psychology and Developing
Societies,AsianJournalofPsychiatry,SocialScienceIndicators,
Psychological Studies, Journal of Indian Academy of Applied
Psychology (ii) Social Scientist External Member, Institute
EthicsCommittee,OxfordCollegeofPhysiotherapy.
Dr. Jamuna Rajeswaran, Additional Professor, (i) Article
Rajeswaran J, Nalini A (2013) Neuropsychological deficits in
amyotrophiclateralsclerosis(ALS):ASouthIndiaexperience,
Neuropsychological Trends 13/2013, was selected as the
most significant research paper in all areas of Psychology (ii)
Member(a)ICMRTaskGroup,Vascularcognitiveimpairment
(iii) Member, Editorial Board for International Journal of
PsychosocialResearch.
Dr. Paulomi M Sudhir, Additional Professor, (i) Member (a)
Regional Advisory Board, Kendriya Vidyalaya Sanghathan
(KVS) (b) Data Monitoring and Safety Committee (DMSC),
Premium randomized controlled trials of lay counsellor
delivered psychological treatments for depressive disorders
andharmfuldrinkinginprimarycare.
Dr.KeshavKumar,AdditionalProfessor,(i)Member,Boardof
Studies(a)BangaloreUniversity(b)UniversityofMysore.
Dr.PoornimaBhola,AssociateProfessor,(i)EditorialCommittee
Member, The Journal of Psychosocial Rehabilitation and
Mental Health (ii) Reviewer: (a) Asian Journal of Psychiatry,
(b)InternationalJournalofSocialPsychiatry(c)Psychological
Studies(iii)FellowofIndianAssociationofClinicalPsychology
andtheIndianAssociationofSocialPsychiatry(iv)Honorary
Positions in Professional Organisations: (a) International
- Coordinator of the All-India CRN Study Group of the
InternationalSocietyforPsychotherapyResearchCollaborative
Research Network, U.S.A. (b) National - Member of the
Ethics Sub-committee of the Indian Association of Clinical
Psychologists.
Dr. BN Roopesh, Assistant Professor, (i) Treasurer, Indian
Association of Clinical Psychologists (ii) Executive Member,
NeuropsychologicalSocietyofIndia.
Dr. Shantala Hegde, Assistant Professor, (i) Reviewer of
scientificpapers14thInternationalSocietyforMusicInformation
RetrievalConference,Curitiba,PR,Brazil,4-8November2013
(ii) Reviewer (ad-hoc) for Journals (a) Neuroscience Letters
(b) Music Perception (c) Asian Journal of Psychiatry (d)
InternationalJournalofYoga.
Epidemiology
Dr.GururajG,Professor&Head,(i)ExpertAdvisor(a)Road
Safety 10, monitoring and evaluation meeting of 10 country
investigators, Baltimore, USA, 8-11 April 2013 (b) Road
Safety 10 partners meeting, New Delhi, 8-9 May 2013 (c)
World International Summit on Health, Doha, Qatar, 10-11
December 2013 (ii) Resource person (a) Technical Advisory
Group meeting for Establishing Burns Registries in India,
Ministry of Health & Family Welfare and Centres for Disease
Controls, USA, 20 November 2013 (b) World Health day
celebrations,WorldHealthOrganisation,IndiaCountryOffice,
New Delhi 4 April 2013 (iii) Member, Technical Advisory
Group meeting of Research Advisory Council of the George
InstituteofHealth,Hyderabad,18May2013(iv)Member(a)
Annual Report
Expert Review Committee for Mid Term Review of Country
Cooperation Strategy (CCS) on Road Safety, Report entitled
‘MidTermReviewofRoadSafetycomponentsunderThailand
Country Cooperation Strategy’, Ministry of Health and WHO
country Office, Thailand, 24 June-July 5 2013 (b) World
Health Organization, Global Road Safety Status Report 2013,
Geneva(c)SteeringCommittee,ICMRTaskForcemeetingon
DisabilityinIndia,NewDelhi,23July2013(v)Expertforthe
Internationalworkinggrouponspinalcordinjurydatasystems
(vi)TechnicaladvisorfortheKSHDRPprojectsonPrevention
andControlofNon-communicableDiseasesandRoadTraffic
Injuries(vii)MonitoringandEvaluationconsultationmeeting
to review progress of data collection activities under RS-10
Project,India,Hyderabad,4March2013(viii)Expertmember:
(a)TaskForceMeetingforInjury,ShockandEmergenciesby
ICMR,NewDelhi,5April2013(b)NationalNon-communicable
DiseaseTechnicalAdvisoryGroupMeetingonPreventionand
Control of Life Style Diseases, Ministry of Health and Family
Welfare, New Delhi, 7 May 2013 (c) RS-10 Stakeholders
Meetingonmonitoringandevaluationtoreviewprogresssofar
andthewayforward,NewDelhi,29May2013.
Dr. Girish N Rao, Additional Professor (i) Founder-member,
GeriatricHealthForum,IndiaunderHelpageIndia(ii)Invitee,
KarnatakaStateMentalHealthAuthority.
2013-14
Development Reforms Project (KHSDRP), Government of
Karnataka(b)SpecificationVettingCommitteeforFunctional
Infrared Brain Imaging with High Density Optical Mapping,
JIPMER,Puducherry(ii)ExpertforAppraisalofPost-Doctoral
FellowshipinNeuroanaesthesia,KIMS,Hyderabad.
Dr. Sriganesh K, Associate Professor, received Best Metro
Branch Award for ISA, Bangalore during ISACON 2013
(acceptedasSecretaryofISA,Bangalore).
Neurochemistry
Dr. Rita Christopher, Professor & Head, (i) Member (a)
Peer Review Committee, XII Five Year Plan Programme on
Facilitating Performance in Military Environment by System
Biology Approach, Defence Institute of Physiology and Allied
Sciences, Delhi (b) ICMR National task force on ‘Inborn
Metabolic Disorders’ (c) Editorial Board, (i) Journal of Basic
Medical and Allied Sciences (ii) International Journal of BioEngineeringandTechnology(iii)InternationalJournalofBioEngineering, (iv) Cardio-Pulmonary Sciences and Technology
(v) International Journal of Bio-Sciences (vi) Psychiatry and
Technology (e) Advisory Board, International Journal of
Innovation.
Dr. Sarada Subramanian, Additional Professor, Member (a)
Executive Committee, Society for Neurochemists of India
(SNCI)(b)DoctoralCommittee,VITUniversity,Vellore.
Human Genetics
Dr. GK Chetan, Additional Professor, Member, European
SocietyofHumanGenetics2013.
Mental Health Education
Dr.JayashreeRamakrishna,Professor,(i)Chairperson,Ethics
Committee of the Foundation of Health Systems Research
(ii) Member, Team 2013 of Swiss Tropical and Public Health
Institute, Basel, Switzerland (iii) Senior Research Consultant,
QualitativeResearchfortheProjecttheDELIVER(Delivering
mEntalheaLthcareinIndiaVianon-spEcialisthEalthwoRkers)
study for Sangath/ London School of Tropical Medicine and
Hygiene (iv) Member, Ethics Committee, Rajeev Gandhi
UniversityofHealthSciences,Bangalore.
Neuroanaesthesia
Dr. V Bhadrinarayan, Professor, (i) Member (a) Core Group
for establishing Guidelines for Essential Trauma Care in
Karnataka under the aegis of Karnataka Health System
Dr. Srinivas Bharath, Additional Professor, Member (a)
Institutional Biosafety Committee (IBSC), Kemwell Pharma,
Nelamangala, Bangalore (b) Board of Studies (BOS), Dept.
of Biochemistry, University of Mysore (c) Ethics Committee,
RangadoraiMemorialHospital,Bangalore.
Neurological Rehabilitation
Dr.AnupamGupta,AdditionalProfessor,Member(a)National
ExecutiveCommittee,IndianAssociationofPhysicalMedicine
and Rehabilitation (b) National Executive Committee, IFNR-
IndianFederationofNeuro-Rehabilitation.
Neurology
Dr. P Satish Chandra, Professor, Director/Vice-Chancellor (i)
received(a)DistinguishedAlumnusofBMCAward,Bangalore
Medical College Alumnus Association, Bangalore, 15 August
2013 (b) Saadaka Ratna Award, by Saheli Foundation,
Bangalore, 15 October 2013 (ii) Chairman (a) South East
Annual Report
2013-14
Regional Committee, International Bureau for Epilepsy (IBE)
(b) Zonal Coordination Committee, Organ Transplantation,
Government of Karnataka (c) Academic Committee, AIIMS,
Bhubaneshwar (d) Colloquium of Epilepsy Conference on
Drug Resistant Epilepsy Classification in Psychiatry DSM-V,
16-18 April 2013 (iii) Member (a) Board of Management,
MGMInstituteofHealthSciences,Navi,Mumbai(b)Working
Group on Equivalence, Medical Council of India, Delhi
(c) Finance Committee, Jayadeva Institute of Cardiology,
Bangalore (d) Scientific Advisory Group (SAG), Division of
Non-communicable Disease, ICMR, New Delhi (e) Governing
Council, Sri. Venkateshwara Institute of Medical Sciences,
Tirupathi(f)TaskForce,IndianCouncilforMedicalResearch
(ICMR)(g)AdvisoryBoardfortheNationalDementiaSummit,
New Delhi 2010 (h) Selection Committee for the post of
Director, Postgraduate Institute of Medical Education and
Research,Chandigarh(i)StandingCommitteeonScienceand
Technology and related matters, constituted by the Ministry
ofHomeAffairs,Govt.ofIndiafromNovember2011forthree
years(j)AdvisoryCommittee,GulbenkianGlobalMentalHealth
Platform, Lisboa, Portugal (k) Scientific Advisory Committee,
National Centre for Disease Informatics and Research,
National Cancer Registry Programme, Department of Health
Research,MinistryofHealthandFamilyWelfare,Government
ofIndia(l)ResearchAdvisoryCouncil,AIIMS,NewDelhi(m)
NationalAdvisoryBoard,JAPI(n)ExecutiveCouncil,Institute
ofHumanBehaviourandAlliedSciences,NewDelhi(o)Indian
CouncilforCulturalRelations(ICCR),NewDelhi(p)Academic
Council,SwamiVivekanandaYogaAnusandhanaSamasthana,
Bangalore (q) Advisory Committee, Bhopal Memorial
Hospital and Research Centre, Bhopal (r) National Advisory
Group, Ministry of Health and Family Welfare, Government
of India, New Delhi (s) MGM Journal of Medical Sciences,
MGM Institute of Health Sciences, Navi Mumbai (t) Genetics
Commission, International League Against Epilepsy, (ILAE)
USA (u) Advisory Committee, Bhopal Memorial Hospital and
ResearchCentre,Bhopal(v)NationalAdvisoryGroup,Ministry
of Health and Family Welfare, Government of India, New
Delhi (w) Special Expert Committee, Department of Health
Research,Delhi(x)ScientificAdvisoryCommittee-Partnership
Programme established by DBT, New Delhi for Advance
Research in Biological Science & Engineering, Department of
Biological Sciences (DBS), IISc,Bangalore (y) NationalThink
Tank (India Backbone Implementation Network–IBIN)-
Planning Commission, Government of India (Secretariat,
Bangalore Baptist Hospital) (z) Standing Finance Committee,
All India Institute of Medical Sciences, Bhubaneswar (iv)
Member(a)AdvisoryCommitteeandInternationalForumon
Innovation on Mental Health. Lisbon. Annual Meeting of the
GulbenkianPlatform’s,Portugal,2-5October2013(b)Editorial
Board,InternationalJournalofEpilepsy(IJEP)(c)HighLevel
AdvisoryCommitteeonNationalPolicyonUniversalElectronic
accessibility constituted by Government of India, Ministry of
Communications and Information Technology, New Delhi,
March2014(c)GoverningBody,JSSMedicalCollege,Mysore
(v) Expert Member, Advisory Panel, National Academy of
Medical Sciences, New Delhi (vi) Co-Chairman, Screening
Committee on Initiative of Neuroclinical Research Education
(INCRE),DepartmentofBiotechnology,GovernmentofIndia,
NewDelhi.
Dr. Veerendra Kumar M, Professor, National Delegate
representing Indian Academy of Neurology to International
FederationofClinicalNeurophysiology.
Dr.SRChandra,Professor,(i)Sectioneditor,Neurologysection
of the sixth edition of Prof. KVK textbook of Medicine (ii)
Reviewer and programme committee member, International
Conference on Neurosciences and Neurobiology Research,
Singapore18-19November2013.
Dr. Pramod K Pal, Professor, (i) Nominated and elected as a
member (a) Education Committee for World Federation of
Neurology-AssociationofParkinsonismandRelatedDisorders
(WFN-APRD) (b) Education Committee, The Movement
DisorderSociety-AsianandOceanianSection(MDS-AOS).
Dr. Subasree R, Assistant Professor, received Young
Investigators/Scientistbursary,WorldCongressofNeurology,
Austria,Vienna,21-26September2013.
Neuromicrobiology
Dr. R. Ravikumar, Professor & Head, (i) External Expert (a)
Institutional Bio-safety Committee Meeting, Institute of Bioinformatics, Bangalore, 30 May 2013 (b) DBT Nominated,
Institutional Bio-safety Committee Meeting, Institute of Bioinformatics, Bangalore, 19 November 2013 (c) to review the
progress of JRF, Institute of Bioinformatics, Bangalore, 23
December 2013 (ii) Master Trainer, Karnataka State AIDS
Prevention Society – Training for Staff Nurses on RTI/STI,
SIHFW, Leprosy Hospital, Bangalore, 16-17 July 2013 (iii)
Mentors for Supportive Supervision-2013, Karnataka State
AIDS Prevention Society, Inspection of KC General Hospital,
Bangalore,3September2013andBangaloreUrbanandRural,
20September2013(iv)Won1stPrizeinQuiz,SEPSISCongress
2013,NewDelhi,4-5December2013(v)Won1stprizeinQuiz,
BalajiInstituteofTropicalMedicine,18January2014.
Annual Report
Dr. Shripad A Patil, Professor, (i) Executive Member, Indian
Immunology Society, 2012-2014. (ii) Scientific expert (a)
Microbiology Department, Gulbarga University, Gulbarga,
2013-14 (b) Microbiology Department, Karnataka University,
Dharwad,2013-14.
Dr. Veenakumari HB, Additional Professor, MCI Assessor,
Govt.MedicalCollege,Azamgarh,2-3May2013.
Neuropathology
Dr.VaniSantosh,Professor,(i)Member,ExecutiveCommittee
for Neurological Society of India (NSI) (ii) External Board
Member, Academic Council and Board of Studies, SCTIMST,
Trivandrum(iii)ExpertMember,VisionGroup-Departmentof
ScienceandTechnology,Govt.ofKarnataka(iv)Externalexpert,
SeniorStaffSelectionCommittee,Sree.ChitraTirunalInstitute
for Medical Sciences and Technology, Thiruvananthapuram,
2013-2014.
Dr.SundarPeriyavan,Professor,(i)Member,TechnicalResource
Group,NACO(ii)Expertmember(a)KarnatakaStateDrugLogistics
and Warehouse Society (b) Karnataka State Blood Transfusion
Council (iii) Co-ordinator, training for blood bank officers, blood
banktechniciansandnursingstaffofbloodbanksinKarnataka.
Dr.GayathriN,Professor(i)Member(a)DoctoralCommittee,
VIT, Vellore (b) Board of Studies, Mount Carmel College,
Bangalore.
Neurophysiology
Dr. TR Raju, Sr. Professor & Head, (i) Elected as Fellow of
Indian Academy of Neurosciences and awarded fellowship,
31st Annual Meeting of Indian Academy of Neurosciences,
Allahabad,25-27October2013(ii)Member(a)ProjectReview
Committee Meeting National Institute of Medical Statistics
(NIMS), Ansari Nagar, ICMR, New Delhi, 8-9 April 2013 (b)
ProjectReviewCommitteeMeeting,ICMRHeadquarters,New
Delhi, 12 November 2013 (c) ICMR – BMBF Meeting, ICMR
Headquarters,NewDelhi,10January2014(d)ExpertGroup,
LawCommissiononJuvenileJusticeSystem,LawCommission
ofIndia,NewDelhiMinistryofLawandJuvenile,Government
of India, New Delhi, 24 January 2014 (iii) Chairman, PRC
Committee, ICMR Headquarters, New Delhi, 26 August 2013
(iv) Chaired (a) ICMR Mentor-Mentee Workshop,Agartala
Government Medical College, Agartala, 3-5 June 2013 (b)
ScientificSessions,3rdICAPSWorkshopAIIMS,NewDelhi,2224December2013(v)InvitedMembertoattendtheTeachings
2013-14
oftheFoundationonThirtySevenpracticesofaBodhisattvaand
Eight verses for training the Mind, Foundation for Universal
ResponsibilityofHHTheDalaiLama,LodiRoad,NewDelhi,
21-23March2014.
Dr. BS Shankaranarayana Rao, Additional Professor, (i)
received(a)ValmikiAwardfortheoutstandingcontributions
and excellence in the field of Medical Sciences, 20 October
2013 (b) Karnataka Padmabhushana Award for outstanding
contributionsandexcellenceinthefieldofNeuromedicineand
forextraordinaryachievementandyeomanservicesrendered
to the country, Karnataka State Mandahaasa Organization,
Bangalore,28April2013(ii)ChairpersonandJudgeforbest
oral and poster presentation competitive session for young
scientists, International Conference on Neurochemistry of
Ageing Brain, CSIR-Indian Institute of Chemical Biology,
Kolkata, 31 January - 1 February 2014 (iii) Resource Person
and Panellist, The Third Bangalore Cognition Workshop:
Where minds meet the brain. Centre for Neuroscience,
Indian Institute of Science, Bangalore, 8-21 December 2013
(iv)ChairpersonofPlenaryLecturesSession,Symposiumon
Medical Physiology and Molecular Genetics, Judge for best
oral presentation competitive session for young scientists.
5th Congress of Federation of Indian Physiological Societies
(FIPS)onPhysiology,Ethnopharmacology,Biotechnologyand
HealthTherapeutics.SriVenkateshwaraUniversity,Tirupati,
India.17-19December2013(v)MemberandResourcePerson,
Indian National Node for Neuroinformatics (INNI) (vi)
MemberofInternationalAdvisoryCommittee,Chairpersonof
PlenaryLecture,andJudge,YoungInvestigatorscompetitive
session. International Conference on Neurosciences: Brain
PlasticityandNeurologicalDisorders.RevenshawUniversity,
Cuttack, 9-11 November 2013 (vii) Member, Conference
Organizing Committee, Chairperson of Symposium (a)
Analytical, Pharmaceutical and Medical Biotechnology and
(b) Nanobiotechnology, Bioinformatics and Bioengineering,
First International and Third National Conference of
Biotechnology, Bioinformatics and Bioengineering. Tirupati,
India, 28-29 June 2013 (viii) Subject expert, Selection of
Researchstaff,DepartmentofZoology,BangaloreUniversity,
Bangalore (ix) Expert member, Peer Review meeting of
DIPAS 12th Five Year Plan on Facilitating Performance in
Military Environment: Systems Biology Approach. Defence
Institute of Physiology and Allied Sciences (DIPAS), Govt.
of India, Ministry of Defence, Research and Development
Organization, Delhi, India (x) Member (a) Board of Studies,
Dr. Ambedkar Institute of Technology, Bangalore, India (b)
Planning Committee, DST-SERB Neuroscience Schools,
DepartmentofScienceandTechnology,GovernmentofIndia
Annual Report
2013-14
(2012–tilldate) (c)InstitutionalEthics Committee, Institute
of Ayurveda and Integrative Medicine (I-AIM), Bangalore
(xi) Secretary, Indian Academy of Neurosciences (IAN) –
Bangalore Branch (xii) Treasurer, Society for Neuroscience
(SFN)–Bangalorebranch(2008–tilldate)(xiii)Reviewer(a)
CSIR,ICMR,DBT,IUSSTFandDSTprojects(b)theAnnual
review of Neuroscience and Pearson’s Biopsychology Book
(xiv)Reviewerforjournals(a)Neuroscience(b)Neuroscience
Letters (c) Pharmacological Research (d) Pharmaceutical
Biology (e) Indian Journal of Medical Research (f) Journal
of Neuroscience Research (g) Neurochemistry International
(h) Brain Research (i) Neurochemical Research (j)
Psychopharmacology(k)MolecularCellularBiochemistry(l)
Physiology and Behavior (m) Pharmacology and Pharmacy
(n)LearningandMemoryand(o)TheInternationalJournal
of Neuropsychopharmacology (xv) Editorial Board Member,
(a) and Editor, Prudence Journal of Medicine and Medical
Sciences (b) Metabolic Brain Disease (c) Journal of Natural
Science Biology and Medicine (d) International Journal of
ModernandAlternativeMedicineResearch(e)Neuroscience
Research Letters (f) Journal of Pharmaceutical and
BiologicalSciences(g)TrendsinBiotechnologyResearch(h)
InternationalJournalofMolecularBiologyandBiochemistry.
Dr. Bindu M Kutty Professor, (i) Member (a) PAC, Health
Sciences, SERB, New Delhi (b) Indian Board for certification
of Sleep Medicine (c) Expert Committee Translational
Neurosciences, ICMR (d) Expert committee of DST- Cognitive
ScienceResearchInitiative(CSI-PDF)forpostdoctoralfellowship
(ii)EditorialBoardMember(a)InternationalJournalofClinical
ExperimentalPhysiology(b)NationalJournalofBasicMedical
Sciences (c) Journal of clinical and Biological Sciences (iii)
TeachingFaculty,NSMC(NationalSleepMedicineCourse–An
IndoUSVenturetopropagatesleepeducation)since2006(iv)
GeneralSecretary,ISSR(IndianSocietyforSleepResearch)(v)
Mentor, ICMR mentor-mentee workshop, ICAP (vi) Reviewer,
CSIR,ICMR,DBT,IJMR,IJEBandDSTprojects.
Dr. TN Sathyaprabha, Additional Professor (i) Member
(a) Doctoral Committee, JIPMER, Pondicherry (b) Ethics
CommitteeatNationalInstituteofUnaniMedicine(c)Scientific
AdvisoryCommitteeandEthicCommittee,JNI,Bangalore(ii)
Secretary, SfN, Bangalore Chapter (iii) Reviewer of Journals:
Hypertension, Acta Scandinavia Neurolgia, Indian Journal of
PhysiologistandPharmacologistofIndia.
Dr.LaxmiTRao,AssociateProfessor(i)Nominatedmember,
University Grant Commission (UGC) for the advisory
committee of Center with Potential for Excellence in a
ParticularArea(CPEPA)ofUniversity ofCalcutta (ii)Elected
ExecutiveMember(a)IndianAcademyofNeuroscience(IAN)
(b)IndianSocietyforSleepResearch(ISSR),India(c)Society
for Neuroscience (SfN) – Bangalore Chapter (iii) Member,
Society for Neuroscience (SfN), USA (iv) Reviewer, Journal
of Neuroscience Research, Brain Research Bulletin, Medical
Hypothesis, J. Bioscience, Brain Research, J Neuroscience
Research,CurrentScience,Ind.JExp.Biology(v)Chairperson,
Symposium on Environment, Nutrition and Brain Function,
31st International Annual Conference of Indian Academy of
Neurosciences (IAN) on Emerging trends and Challenges in
Neuroscience,Allahabad,UttarPradesh,India,25-27October
2013.
Dr. Phalguni Anand Alladi, Sr. Scientific Officer, received
funding of US$5000 from the International Parkinson and
MovementDisordersSociety(USA)toconducttheParkinson’s
Disease Education Program titled Understanding Parkinson’s
Disease: From Clinics to Basics, 5-7 March 2014 under the
DWEPScheme.
Mr.VidyadharaDJandMr.VijayakumarKreceived2ndPrize
in Quiz competition, 59th Annual National Conference of
Association of Physiologists and Pharmacologists of India
on Decades of Research in Physiology and Pharmacology:
Reminderstorememberandfocus.
Mr. Vidyadhara DJ and Mr. Vijayakumar K
Neurovirology
Dr.VRavi,Professor&Head,(i)receivedExcellenceinVirology
Award,IndianVirologySociety,foroutstandingcontributions
to Medical Virology, Asia Pacific Congress of Virology, Amity
University, New Delhi, 16-20 December 2013. (ii) Member,
InstituteBody,AcademicCouncil,StandingFinanceCommittee,
StandingSectionCommitteeofAIIMS,Raipur.
Annual Report
Dr. V Ravi, receiving the “Excellence in Virology” Award from the Chancellor of
Amity University
Dr. Anita Desai, Additional Professor, (i) invited by (a)
Department of Communicable Diseases, World Health
Organization,andRegionalOfficeforSouthEastAsiatoassess
the Public Health Laboratories, Male, Maldives, 11-17 August
2013 (b) WHO SEARO as faculty on the HIV - Point of Care
Diagnosticsworkshop,NARI,Pune,20-24August2013.
Nursing
Dr. K Lalitha, Professor & Head, (i) Chief Guest (a) Nurses’
Week Valedictory Function, St. John’s National Academy of
Health Sciences, College of Nursing, Bangalore, 10 May 2013
(b) International Conference on Group Dynamics, Krishna
Institute of Nursing Sciences, Nellore, Andhra Pradesh, 26
July2013(c)NationalNursingConference,GangaInstituteof
HealthSciences,Coimbatore,14September2013(d)National
Conference, Dhanalakshmi Srinivasan College of Nursing,
Perambalur, Tamil Nadu, 12 October 2013 (e) Lamp Lighting
Ceremonyof12thBatchofGNMStudentsand11thBatchofBSc
Nursing Students, Narayana Hrudayalaya College of Nursing,
Bangalore, 20 December 2013 (f) Lamp Lighting Ceremony,
Kempegowda Institute of Nursing Sciences, Bangalore, 6
March2014(ii)GuestofHonour,National-levelWorkshopon
BuildingontheBest:AccentuatingYourExpertiseinResearch
andStatisticsforthebenefitofnursingpersonnel,Continuing
EducationDepartment,JSSCollegeofNursing,MysoreandI
and II year M.Sc. students, 16 December 2013 (iii) Member,
SchoolofHealthSciences,IGNOU,NewDelhi(iv)Member(a)
SNEHProject,ShareIndia(b)GoverningBodyofRVSInstitute
of Health Sciences, Coimbatore, (c) Board of Studies Mother
Theresa Post Graduate and Research Institute of Health
Sciences, Puducherry (d) PhD Committee, School of Health
Sciences,IGNOU,NewDelhi(e)WorkingCommitteeKHSDRP
HealthandFamilyWelfareDepartmentGovt.ofKarnataka,(f)
GoverningCouncilforNursing,PIMS,Pondicherry(g)Boardof
StudiesofPIMS,PondicherryforUG/PG(h)GoverningCouncil
Member of R.V.S Educational Trust, Coimbatore (i) Advisory
BoardofGoverningBody,InstituteofNursingScienceStudies
andResearch(INSSR),Gwalior,MadhyaPradesh(j)Boardof
2013-14
StudiesinNursingforframingofsyllabusforvariousNursing
CoursesofSri.BalajiVidyapeethUniversity,Pillaiyarkuppam,
Pondicherry (k) Peer Review Committee, TNAI Editorial
Advisory Board (EAB) (l) Reviewer, NITTE Nursing Journal
(m) Editorial Board, Journal of Krishna Institute of Medical
Sciences University (n) Editorial Board, Nursing Journal of
India(o)EditorialBoard,Prism’sNursingPracticeJournalof
ClinicalNursingEducation,TrainingandCareerDevelopment.
(iv) Chaired session on ‘Innovation in Psychiatric Nursing
Rehabilitation Services’, National Conference on Psychiatric
Rehabilitation: Focus on Recovery, NIMHANS, Bangalore, 8
March,2014.
Dr.K.Reddemma,SeniorProfessor,(i)invitee(a)Emergency
General Body Meeting, Indian Nursing Council, New Delhi,
22 June 2013 (b) Third Meeting of the National Council for
ClinicalEstablishment,MinistryofHealthandFamilyWelfare
(MHWF), Resource Centre, Nirman Bhavan, New Delhi, 24
June2013.
Dr. Ramachandra, Additional Professor, (i) Guest of Honour
(a) “Deepaloka” and “Padavidharotsava”, IKON Nursing
College, Bidadi, 12 July 2013 (b) Annual Day Function,
Jupiter College of Nursing, Bangalore, 28 February 2014 (ii)
Chief Guest (a) Inaugural Programme, Session on Glance
on Complementary and Alternative Therapies, State-level
Conference on Complementary and Alternative Therapies in
Psychiatry, Nursing Delegates, Laxmi Memorial College of
Nursing, Mangalore, 28 November 2013 (b) Lamp Lighting
CeremonyfortheBScNursing2013Batchstudents,JIPMER,
Pondicherry, 31 January 2014 (iii) Member, Core Group
Committee, Core Group of National Consortium for PhD in
Nursing,IndianNursingCouncil,NewDelhi.
Dr. Sailaxmi Gandhi, Assistant Professor, receiving the prestigious National
Florence Nightingale Award from the Hon’ble President of India Shri. Pranab
Mukherjee at the Rashtrapati Bhavan, New Delhi
Dr. Sailaxmi Gandhi, Assistant Professor, (i) received the
prestigious National Florence Nightingale Award from
the Hon’ble President of India attheRashtrapatiBhavan,
Annual Report
2013-14
NewDelhiontheoccasionofNursesDay2014 (ii)ChiefGuest,
Valedictory Function, Workshop on Nursing Informatics,
Narayana Hrudayalaya College of Nursing, Bangalore, 27
November 2013 (iii) Associate Editor, Journal of RGUHS
NursingsciencespublishedbyRGUHS,Bangalore(iv)Specialty
fieldeditor,IndianJournalofPsychiatricNursing(v)Member
(a)AdvisoryBoardfortheIndianJournalofContinuingNursing
Education published by CMC College of Nursing, Vellore (b)
Local Editorial Board, Journal of Psychosocial Rehabilitation
andMentalHealth(vi)Reviewer,SageOpenJournals.
Dr. Prasanthi Nattala, Assistant Professor, Winner of ‘Teach
OutoftheBox’CompetitiononInnovativeTeachingMethods,
2ndJointConferenceoftheNationalInstituteofMentalHealth
andNeuroSciences,India,andRoyalCollegeofPsychiatrists,
UK(NIMRCPSYCON),TeachingMethodpresented:Integrated
audio visual aided interactive relapse prevention intervention
forindividualswithalcoholdependence,8March2014.
Mr. S Shankaraiah, Sr. Nursing Tutor, felicitated at the
12thNationalConferenceofISPN,St.John’sCollegeofNursing,
Bangalore.
Smt.AVimalaMonicaandSri.PrasannaKumarG,StaffNurses,
awarded‘BestNurses’fortheyear2012-13ontheoccasionof
InternationalNursesDay,15May2013.
Psychiatry
Dr. Mathew Varghese, Professor & Head, (i) Member (a)
Technical Advisory Committee, Longitudinal Ageing Study in
India (LASI), International Institute for Population Studies,
Mumbai(b)WHOConsultationGroupontheClassificationof
Behavioural and Psychological Symptoms in Neurocognitive
Disorders for ICD-11, WHO, Geneva (c) Executive Board,
InternationalNeuropsychiatricAssociation.
Dr. SK Chaturvedi, Professor, (i) Member (a) Committee
constituted to look into the structure and system of CIP
Ranchi, under the Chairmanship of Ms. Sujaya Krishnan,
Joint Secretary, Ministry of Health & Family Welfare, Govt.
of India, New Delhi (b) International Advisory Board,
International Journal of Social Psychiatry, UK (c) Editorial
Board,InternationalPsychiatry,RoyalCollegeofPsychiatrists,
UK (ii) Expert Core Group member, MOHFW, IPS and PHFI
on Training Programme for Primary Care Doctors on Mental
Disorders (iii) Chairperson, PG Training Taskforce, Indian
PsychiatricSociety(iv)Editor-in-Chief,JournalofPsychosocial
Rehabilitation&MentalHealth,SpringerVerlag,2014.
Dr. Prabha S Chandra, Professor, Fellow of the National
AcademyofMedicalSciences–FAMSawardedin2013.
Mrs. H. Dorothy Paripoornam, Staff Nurse, receiving the State Florence
Nightingale Award from the Hon’ble Chief Minister of Karnataka Shri.
Siddaramaiah
Dr. Pratima Murthy, Professor, (i) Member (a) IRB, Karuna
Trust(b)ICMRtaskforceondrugabuseinPunjab,ICMR,New
Delhi (c) Local Editorial Board, the Journal of Psychosocial
RehabilitationandMentalHealth(ii)Adhocreviewer:IndianJ
Psychiatry;SubstanceAbuseTreatment,Prevention,andPolicy;
IndianJMedicalResearch,JournalforIndianAssociationfor
ChildandAdolescentPsychiatry.
Mrs.H.DorothyParipoornam,StaffNurse,receivedthe State
Florence Nightingale Award from the Hon’ble Chief
Minister of Karnataka at VidhanaSoudha,Bangaloreonthe
occasionofNursesDay2014
Dr. YC Janardhan Reddy, Professor, Member, WHO
International Advisory Group for Revision of ICD-10 Mental
andBehavioralDisorders:WorkingGroupontheClassification
ofObsessive-CompulsiveandRelatedDisorders.
Smt. Bhanu MR, Staff Nurse, received ‘Florence Nightingale
Award’,institutedbyC.KrishniahChetty&SonsFoundation,
Bangalore,ontheoccasionofInternationalNursesDay2013,
15May2013.
Dr.VivekBenegal,Professor,(i)Member(a)TechnicalAdvisory
Group on Alcohol Control, Government of India, (2013–till
date)(b)NationalCommitteeofExpertsonHarmReduction,
MinistryofFinance,GovernmentofIndia(c)FacultySelection
Annual Report
2013-14
Committee,LGBRegionalInstituteofMentalHealth,Tezpur,
Assam, (2012–till date) (d) Screening Committee, National
AwardsforOutstandingServicesinPreventionofAlcoholand
DrugAbuse,2013.
(iii) Felicitated by School of Social Work, Roshni Nilaya,
Mangalore and Roshini Alumini Association, in recognition
ofhisprofessionalcontributioninSocialWork,CenturyClub,
Bangalore,19October2013.
Dr. G Venkatasubramanian, Additional Professor, received
Professor Raguram Distinguished Young Teacher Award,
IndianPsychiatricSociety(KarnatakaChapter).
Dr. R Dhanashekara Pandian, Additional Professor, (i)
Honorary Board Member (a) International Alcohol and Drug
Counselor’sCertificationTrustforIndia(IADCC)(b)Academic
Council, Madurai Institute of Social Sciences, Madurai (ii)
Honorary Treasurer, Indian Society of Professional Social
Work(ISPSW),22January2014
Dr. CN Janardhanan, Assistant Professor, Editorial Board
Member,WorldJournalofClinicalCaseReports.
Dr. K Sekar, Professor & Head, (i) President, Indian Society
ofProfessionalSocialWork(ii)Treasurer,IndianAssociation
of Social Work Educators, TISS, Mumbai (iii) Member (a)
Board of Exam in Punjab University, Patiala (b) Board of
Appointment, Examination, Central University of Karnataka,
Gulburga (c) Board of Studies and Examination, LGBRIMH,
GauhatiUniversity,Tezpur(iv) Coregroupmember,National
Guidelines on Minimal Standards in provision of relief for
women and children in disaster. NDMA, Ministry of Home
Affairs, Govt. of India (v) Board Member, Institute for Youth
Development,Bangalore.
Dr. N Krishna Reddy, Additional Professor, (i) Honoured for
special contribution in De-Addiction services in Bangalore,
People’s Awareness programme, Federation of De-Addiction
and Rehabilitation Centres for Chemical Substance Abuses
(FEDRCSA), Ravindra Kalakshethra, Bangalore, 8 January
2014 (ii) Re-elected as Vice President, ISPSW, 2014-2015
Dr. Ameer Hamza, Associate Professor, (i) Chairperson, 32nd
ANC, ISPSW Conference, Bijapur, Karnataka (ii) General
Secretary,IndianSocietyofProfessionalSocialWork(iii)Ethics
CommitteeMember,NationalInstituteofUnaniMedicine.
Psychopharmacology
Dr. Chittaranjan Andrade, Professor, (i) Chairperson, Indian
PsychiatricSocietyTaskForceonPositionStatements(ii)Member,
EditorialBoard,JournalofClinicalPsychiatry(iii)AdvisoryBoard
Member,IndianAssociationofPrivatePsychiatry.
Speech Pathology and Audiology
Dr.NShivashankar,Professor&Head,Chairperson,Seva-inAction,Bangalore.
Dr.MJayaram,Sr.Professor,(i)Member(a)AcademicCouncil,
AYJNationalInstitutefortheHearingHandicapped,Mumbai
(b)ExpertCommittee,RCIInspections.
Annual Report
2013-14
Photo:Dr.GautamK,Prof.BNGangadhar,Dept.ofPsychiatry,NIMHANS
Visitors to NIMHANS
1.
Prof. Narinder Kapur, Visiting Professor of
Neuropsychology,ResearchDept.ofClinical,Educational
and Health Psychology, University College London,
visited the Dept. of Clinical Psychology, and spoke on
‘Penetratingheadinjuryandmemory’,4April2013.
2.
Dr. Thomas H Bak, Lecturer, Human Cognitive
Neuroscience(HCN)andCenterforCognitiveAgingand
CognitiveEpidemiology(CCACE),SchoolofPhilosophy,
Psychology and Language (PPLS), University of
Edinburgh,visitedtheDept.ofClinicalPsychologyand
spoke on ‘Impact of linguistic diversity on aphasia and
cognition’,4April2013.
3.
Dr.JNathan,Neurophysician,Mumbai,visitedtheDept.
ofNeurologyanddeliveredaguestlectureon‘Ketogenic
dietindifficulttotreatepilepsy’,27April2013.
4.
Dr. Bontha V Babu, Scientist-E (Deputy Director
General), ICMR, New Delhi, visited the Dept. of
PsychiatricSocialWork,andspokeon‘Writingproposal
forResearchGrants’,4May2013.
5.
Prof. S Prasad, Biochemistry and Molecular Biology
Laboratory, Department of Zoology, Banaras
Hindu University, Varanasi, visited the Dept. of
Neurophysiology,andspokeon‘Cellularandmolecular
basisofdiabetesmellitusinducedlearningandmemory
impairmentandneuro-protectiveroleofbrahmiextract
inmice’,13May2013.
6.
Dr. Devashish Sengupta, Assistant Professor, Dept. of
Organic Chemistry, Assam University, Silchar, Assam,
visitedtheDept.ofNeurochemistry,andspokeon‘Nanoassistedorganicphotosensitizers:Theirdesign,synthesis,
characterizationandbothlightactivatedand/ornon-light
activatedbiologicalapplications’,29May2013.
7.
Dr. Mohan Issac, Professor of Psychiatry, University of
Western Australia, visited the Dept. of Epidemiology,
andspokeon(a)‘IntegrationofNMHP&DHPatdistrict
levelDHPBellarymodel’,31May2013(b)‘Community
MentalHealthProgramme’,19December2013.
8.
Dr. Arthi Kanthasamy, Associate Professor, Dept. of
BiomedicalSciences,IowaStateUniversity,Ames,USA
Annual Report
2013-14
visited the Dept. of Neurochemistry, and delivered a
lecture on ‘Histone modification and dopaminergic
neurodegeneration: Relevance to etiopathogenesis of
Parkinson’sdisease’,24June2013.
9.
Dr.AnumanthaKanthasamy,Professor&Chair,Dept.of
BiomedicalSciences,IowaStateUniversity,Ames,USA
visitedtheDept.ofNeurochemistry,24June2013.
10.
Dr. Monica Vavilala, Professor of Anesthesiology and
Pediatrics, University of Washington, Seattle, WA, USA
visitedtheDept.ofNeuroanaesthesia,anddeliveredalecture
on‘Managementofthepediatricheadinjuries’,29June2013.
11.
Prof.MKUnnikrishnan,ManipalCollegeofPharmaSciences,
Manipal University, visited the Dept. of Neurophysiology,
andspokeon‘Theexceptionreportmodeloffacerecognition:
Theevolutionarylinkbetweenperceptionofbeautyandthe
recognitionofindividuality’,29June2013.
12.
Dr. C Shamasundar, Retd. Professor of Psychiatry,
NIMHANS, Bangalore, visited the Dept. of
Neurophysiology, and spoke on ‘Science & Religion in
India:AHistoricalPerspective’,1July2013.
13.
Dr. Aravindan Natarajan, Assistant Professor of Social
Work,UniversityofToledo,Ohio,USA,visitedtheDept.
ofPsychiatricSocialWork,andspokeon‘Exploringuse
ofartsinqualitativeresearch’,3July2013.
Dr. Robert D Stevens and Dr. Akhilesh Pandey from Johns Hopkins University
with the Director/Vice-Chancellor, NIMHANS
14.
AdelegationfromJohnsHopkinsUniversity,USAledby
Dr.RobertDStevens,AssociateProfessor,Departments
of Anesthesiology/Critical Care Medicine, Neurology,
Annual Report
2013-14
Neurosurgery and Radiology, Dr. Akhilesh Pandey,
Professor of Biological Chemistry and Mr. Dominic
SeraphinvisitedNIMHANS,11-12July2013.
15.
Dr.PruthvishS,ProfessorofCommunityMedicine,MS
Ramaiah Medical College, Bangalore, visited the Dept.
ofEpidemiologyanddeliveredalectureon‘Community
based rehabilitation of persons with disability’, 30 July
2013.
16.
Dr.ArunAngeloPatil,Prof.ofSurgery,NebraskaMedical
Centre, Omaha, NE visited the Dept. of Neurology,
and spoke on ‘Long term outcome of Hippocampal
transactionforrefractoryepilepsy’,8August2013.
17.
A delegation of Government Officials from Sri Lanka:
Mr. Sanjeev Tanpatta, National Hospital of Sri Lanka,
Colombo;Dr.SriromiMDeSilvaMaduwage,Consultant,
Community Practice, Ministry of Health, Colombo,
Mr. Subhabrata Samal, Rehabilitation Coordinator,
Handicap International; Dr. P Karthikeyan, Regional
Director of Health, Kilinochchi; Dr. SHM De Silva,
HeadofRehabilitationDepartment,NationalChildren’s
Hospital, Colombo; Ms. SC Koralagama, Manager,
P&O Dept., National Children’s Hospital, Colombo;
Dr. WLLUC Kumarathilake, Director, Disability and
DisplacedPersons,MinistryofHealth,Colombo;Dr.LM
Navaratnarajah, Deputy Director, Teaching Hospital,
Batticaloa;Mr.RSSelvaretnam,Manager,Rehabilitation
Centre, Teaching Hospital, Batticaloa; Mr. Nadaraj
Thileepan, General Secretary, National Occupational
Therapy Association; Mr. HPU Mihiran, Executive
Member, National P&O Society; Mr. TMU Sanjeewa
Tunpattu, General Secretary, National Physiotherapy
Association,visitedtheDept.ofPsychiatricRehabilitation
Service,8August2013.
18.
Prof. Tom Solomon and his team of faculty from the
UniversityofLiverpool,UKvisitedNIMHANSon12-14
August2013.
A team of faculty from the University of Liverpool led by Prof. Tom Solomon
19.
Prof. Shu Leong HO, Henry G Leong Professor
in Neurology and Chief of Division in Neurology,
DepartmentofMedicine,TheUniversityofHongKong,
delivered a lecture on ‘Disease progress modification
in Parkinson’s disease’. Prof. LEE Tatia Mei-chun,
May Professor in Neuropsychology and Chair Prof.
of Psychology, Honorary Professor, Department
of Psychiatry and Department of Medicine, The
University of Hong Kong delivered a lecture on
‘SocialAffectiveNeuroscience:Emotionrecognitation
and regulation’. Prof. Li-Hai TAN, Professor of
Linguistics and Brain and Cognitive Sciences, School
of Humanities (Linguistics), Founder and Director,
StateKeyLaboratoryofBrainandCognitiveSciences,
‘The University of Hong Kong delivered a lecture on
Brain mechanism of language: Universal or culture–
specific?’,20August2013.
20.
Prof. Dinesh Bhugra, Professor of Mental Health and
CulturalDiversity,InstituteofPsychiatry(KCL),London,
President–Elect, World Psychiatric Association, visited
theDepartmentofPsychiatry,NIMHANS,anddelivered
a lecture on “Prevention of Mental Disorders” on 23
August2013.
21.
Dr. David Clifford, Professor of Neurology, St Louis
School of Medicine, Washington University, USA, and
Dr. Avindra Nath, Clinical Director of NINDS, Chief,
Section of Infections of Nervous System, NIH, USA
visitedNIMHANSon29August2013.
A delegation of Government Officials from Sri Lanka
Annual Report
2013-14
Transitions in Potassium Channels during Gating’, 24
September2013.
28.
Dr. Tanya Machado, Professor of Clinical Psychology,
and Dr. Vijaya Raman, Associate Professor of Clinical
Psychology, Dr. Vidya Sathyanarayanan, Associate
Professor of Clinical Psychology, St. John’s Medical
College & Hospital, Bangalore, visited the Dept. of
ClinicalPsychology,andspokeon‘ClinicalPsychologyin
ConsultationLiasonSetting’,29September2013.
29.
Dr. Meenakshi Venkataraman, USA, visited the Dept.
of Psychiatric Social Work, and spoke on ‘Social work
theories: positives, problems and specified’, 10 and 17
October2013.
30.
Ms. Stuti Kacker, Secretary to GOI, Dept. of Disability
Affairs, Ministry of Social Justice and Empowerment
and Mr. KVS Rao, Director, Dept. of Disability Affairs,
MinistryofSocialJusticeandEmpowermentvisitedthe
Dept. of Psychiatric Rehabilitation Service, 24 October
2013.
Dr. David Clifford, Professor of Neurology, St Louis School of Medicine,
Washington University, USA
22.
Dr. Sudhakar Subramani, Associate Professor of
Anaesthesiology, Iowa State University, Ames, USA,
visited the Dept. of Neuroanaesthesia, and spoke on
‘Hemodynamic assessment using echocardiography’, 2
September2013.
23.
Dr. Chetan Rao, Assistant Professor of Neurocritical
Care, and Director of Neurocritical Care, Bayer College
of Medicine, Houston, Texas, USA visited the Dept. of
Neuroanaesthesia, and spoke on ‘Evidence based acute
managementofischemicstrokeandneurocriticalcare’,
3September2013.
24.
Dr. Rajasekaran, San Diego Healthcare System, CA,
US,visitedtheDept.ofNeurophysiology,andspokeon
‘Experimental models for evaluation of genito-urinary
andpelvicfloordisorders’,3September2013.
25.
Dr.RajanGurukkalSoundararajan,Chairperson,Centre
for Contemporary Studies, IISc, Bangalore, visited the
Dept. of Psychiatric Social Work, and spoke on ‘Social
theoryofknowledgeproduction’,18September2013.
26.
27.
Prof. Waltraud Ernst, Professor, History of Medicine,
Oxford Brookes University, visited NIMHANS and
presented a paper on History of Psychiatry in India at
a seminar on “Institutional mortality rates, long-term
confinement and causes of death in an Indian Mental
Hospitalduringtheearlytwentiethcentury”,Department
ofPsychiatry,12September2013.
Raghuraman H, Scientist, Department of Biochemistry
andMolecularBiology,TheUniversityofChicago,USA,
visitedtheDept.ofBiophysicsandspokeon‘Dynamics
Ms. Stuti Kacker, Secretary to GOI, Dept. of Disability Affairs, Ministry of Social
Justice and Empowerment and Mr. KVS Rao, Director, Dept. of Disability Affairs,
Ministry of Social Justice and Empowerment
31.
Dr. Narendranath, Professor & Head of Hospital
Administration, MS Ramaiah Medical College,
Bangalore, visited the Dept. of Epidemiology, and
spokeon‘Introductiontomanagementofinventoryand
HumanResourcemanagement’,29October2013.
32.
Mr.ParassinrajTS,SeniorExecutivePWD;Ms.Nelufer
B,CenterCo-OrdinatorPWD;Reddy’sFoundation;Ms.
Sangeeta K, Assistant Manager/Operations, Dr. Reddy
FoundationvisitedtheDept.ofPsychiatricRehabilitation
Service,30October2013.
Annual Report
2013-14
33.
Prof.NancyReynolds,YaleUniversity,visitedtheDept.
of Psychiatry, and spoke on ‘Medication Adherence in
themedicallyill’,31October2013.
34.
A team of faculty from Deakin University, Melbourne,
Australia visited NIMHANS and discussed possible
collaborations with the Department of Clinical
Psychologyon18-19November2013.
37.
Prof. Thomas Metzinger, Professor of Theoretical
Philosophy, Johannes Gutenberg University Mainz,
visitedtheDept.ofPsychiatry,anddeliveredalectureon
thetopic‘FromNeuroethicstoConsciousnessEthics’,3
December2013.
38.
Mr.CKMishra,AdditionalSecretary,MinistryofHealth
& Family Welfare, GOI, visited the Dept. of Psychiatric
RehabilitationService,4December2013.
39.
Dr.RobertK.Shepherd,Director,BionicsInstituteand
Professor of Medical Bionics, University of Melbourne,
AustraliavisitedNBRCandtheDept.ofNeurophysiology,
and delivered a lecture on ‘Medical bionics: Neural
interfacesfordamagednerves’,5December2013.
40.
Dr. DM McLaughlin, TCD, Ireland, visited the Dept. of
PsychiatricRehabilitationservice,6December2013
41.
Prof. Harry Steinbusch, Director of Clinical
Neurosciences, Maastricht University, Netherlands,
visitedNIMHANSanddeliveredalectureon“Brainstem
DysfunctioninNeurodevelopmentandNeuropsychiatric
Disorders—MovingfromForebraintotheBrainstem”,7
December2013.
A team of faculty from Deakin University, Melbourne, Australia
35.
Dr.UpendraBhojani,Faculty,InstituteofPublicHealth,
BangalorevisitedtheDept.ofEpidemiology,andspoke
on‘Healthpromotion’,16November2013.
36.
Prof.Dr.HabilUlrikeM.Ludtke,DepartmentofSpeech
and Language Pedagogy & Therapy, Leibniz University
of Hannover, Germany visited the Dept. of Speech
Pathology and Audiology, and spoke on ‘Early child
languagedevelopmentlab’,19November2013.
Prof. Harry Steinbusch, Director of Clinical Neurosciences, Maastricht University,
Netherlands
42.
Dr.JogiVPattisapu,PaediatricNeurosurgeon,Flordia,
USAvisitedtheDept.ofNeurosurgeryandgavealecture
demonstration,9December2013.
43.
Dr. Jean Louis Lamboray, Founder & Chairperson,
Constellation for Community Life Competence, visited
the Dept. of Psychiatric Social Work, and spoke on
Prof. Thomas Metzinger, Professor of Theoretical Philosophy, Johannes
Gutenberg University Mainz
Annual Report
‘Strengthbasedapproachtocommunitydevelopment’,9
December2013.
44.
Dr.SiyaramPandey,Professor,DepartmentofChemistry
and Biochemistry, University of Windsor Essex Hall,
Ontario, Canada, visited the Dept. of Neurochemistry,
and delivered a lecture on ‘Halting Progression of
Neurodegeneration by Water-Soluble CoQ10 in Rat
andMouseModelsofSporadicandGeneticParkision’s
Disease’,11December2013.
45.
Dr. Anita Jain, Editor (India), British Medical Journal
India visited the Dept. of Epidemiology, and spoke on
‘Ethics and quality of medical research in India’, 18
December2013.
46.
Ms. Achla Singh, Director (SW), Department of Social
Welfare, Govt. of NCT of Delhi with Mr. N Agarwal,
Dr. BS Banerjee, Mr. V Kapur, Govt. of NCT of Delhi,
visitedtheDept.ofPsychiatricRehabilitationService,18
December2013.
47.
2013-14
50.
Dr.RMubarakAli,Faculty,Dept.ofSocialWork,Flinder’s
University, Adelaide, visited to the Dept. of Psychiatric
Social Work, and spoke on ‘Internet technology – use
and abuse: role of mental health professionals’, 13
January2014.
51.
Prof. Mathias Berger. Director of Psychiatry and
Psychotherapy,UniversityHospitalFreiburg,Germany,
visited the Dept. of Clinical Psychology and spoke on
‘Cognitivetherapyfordepression’,15January2014.
52.
Prof. Lakshmi N Yatham, Director, Mood Disorders
Clinical Research Unit, The University of British
Columbia, visited the Dept. of Psychiatry, and spoke
on ‘Recent advances in diagnosis and management of
bipolardisorder’,16January2014.
53.
Dr.AntonyGuyMarsonfromtheUniversityofLiverpool
visitedtheDept.ofNeurology,andspokeon‘Predicting
seizure outcome following a first seizure and new
epilepsy’,17January2014.
Dr. Finsterer J, Professor of Neurology, University
of Vienna, Austria, visited the Dept. of Neurology,
and delivered a lecture on Phenotypic Features of
MitochondrialDisorders,on21December2013.
Dr. Antony Guy Marson, University of Liverpool
54.
Dr. T Hemanth, Professor of Community Medicine,
MS Ramaiah Medical College, visited the Dept. of
Epidemiology, and spoke on ‘Dioxins and furans from
biomedical waste and its health impacts’, 20 January
2014.
55.
Dr. Surendra VHH, Joint Director, Dept. of Factories,
Boilers, Industrial Safety and Health, Government of
KarnatakavisitedtheDept.ofEpidemiology,andspoke
on‘TheIndianfactoriesactincontextofmentalhealth’,
21January2014.
56.
Dr. Govindaiah, Scientist, University of Louisville,
Kentucky, USA, visited the Dept. of Neurophysiology,
andspokeon‘Optogeneticsapproachesinneuroscience’,
28January2014.
Dr. Finsterer J, Professor of Neurology, University of Vienna, Austria
48.
Dr. Mohan Issac, Professor of Psychiatry, University of
Western Australia, visited the Dept. of Psychiatry, and
spokeon‘CommunityPsychiatry’,16-23December2013.
49.
Dr.ChitraDMandyam,AssociateProfessor,Committee
on Neurobiuology of Addicitive Disorders, The Scripps
ResearchInstitute,LaJolla,CA,USA,visitedtheDept.
ofNeurophysiology,andspokeon‘Relationshipbetween
hippocampal neurogenesis and methamphetamine
dependence:HopeorHype?,on27December2013.
Annual Report
57.
2013-14
Prof.SanjeevArora,DirectorofProjectECHO(Extension
for Community Healthcare Outcomes), University
of New Mexico Health Sciences Center (UNMHSC),
Albuquerque, USA visited the Dept. of Psychiatry and
spoke on ‘Project ECHO (Extension of Community
Healthcare Outcome) model and its replication efforts
acrossdifferentpartsoftheworld’,10February2014.
Prof. Sanjeev Arora, Director of Project ECHO (Extension for Community
Healthcare Outcomes), University of New Mexico Health Sciences Center
(UNMHSC), USA
58.
Dr.BrigitteSebastia,Anthropologist,FrenchInstituteof
Pondicherry,visitedtheDept.ofPsychiatryandspokeon
‘Filmscreeninganddiscussion’,18February2014.
59.
Dr.MSKeshavan,StanleyCobbProfessorofPsychiatry,Beth
Israel Deaconess Medical Center, Harvard, Boston, visited
theDept.ofPsychiatryandspokeon‘Currentperspectives
onPsychiatricclassification’,20February2014.
60.
Bernadette Abela, Team leader, Neglected Zoonotic
Diseases,WHO,Geneva,andGyanendraGongal,Disease
Surveillance&Epidemiology,WHOSEARO,NewDelhi,
visitedtheDept.ofNeurovirology,22February2014.
61.
Prof. Dr. Be-Hazir Ahmed,Disease Control, DGHS,
Bangladesh, visited the Dept. of Neurovirology, 22
February2014.
62.
Dr. Plavi Mittal, President and CEO, Jain Foundation,
USA, visited the Dept. of Neurology, and spoke on
‘EndingthediagnosticOdysseyforLGMDpatients’,28
February2014.
63.
Dr.SrinivasBabu,ProfessorofClinicalNeurophysiology,
CMC, Vellore, Tamil Nadu, visited the Dept. of
Neuroanaesthesia and spoke on ‘Intraoperative
neurophysiologymonitoring’,1March2014.
64.
AteamoffacultyfromUniversityofLiverpoolheadedby
Dr.RobertSHydermanvisitedtheDept.ofNeurovirology
and the Dept. of Psychiatry, and spoke on ‘Bacterial
MeningitisinAfrica:newinsightsintooldproblem’,14
March2014.
65.
Prof. Neil French, Dept. of Clinical Infection, Royal
Liverpool & Broadgreen University Hospital Trust,
visitedtheDept.ofPsychiatry,andspokeon‘Adjuvant
therapiesandVaccinesinbacterialmeningitis’,14March
2014
66.
Dr. Lisa FP, University of Liverpool, visited the Dept.
of Neurovirology, and spoke on Chikungunya virus
infections-immunologicalaspects’,17March2014.
67.
Dr. Andrew Amos Channon, Senior Lecturer and Dr.
ClaireBailey,Lecturer,DivisionofSocialStatistics and
Demography, University of Southampton, UK with a
groupofstudents(12)visitedtheDept.ofMentalHealth
Education, and delivered a lecture on ‘Importance of
qualitative methods in ethical research on culturally
sensitivehealthissues’,25March2014.
A team of faculty and students from Division of Social Statistics and Demography,
University of Southampton, UK
2013-14
Annual Report
Patient Care Activities
REGISTRATIONS
PSYCHIATRY
CHILD PSYCHIATRY
NEUROLOGY
NEUROSURGERY
25000
NO. OF PATIENTS
20000
SCREENING
15000
10000
120000
5000
08-09
09-10
10-11
11-12
12-13
NO. OF PATIENTS
0
100000
13-14
YEARS
80000
60000
40000
20000
0
08-09
09-10
10-11
11-12
12-13
13-14
YEARS
EMERGENCIES (CASUALTY)
PSYCHIATRY
CHILD PSYCHIATRY
NEUROLOGY
NEUROSURGERY
20000
18000
16000
ADMISSIONS
12000
10000
PSYCHIATRY
8000
CHILD PSYCHIATRY
NEUROLOGY
NEUROSURGERY
7000
6000
4000
6000
2000
5000
0
08-09
09-10
10-11
11-12
YEARS
12-13
13-14
NO. OF PATIENTS
NO. OF PATIENTS
14000
4000
3000
2000
1000
0
08-09
09-10
10-11
11-12
12-13
13-14
YEARS
Annual Report
2013-14
DISCHARGES
PSYCHIATRY
CHILD PSYCHIATRY
NEUROLOGY
NEUROSURGERY
6000
4000
FOLLOW-UPS
3000
PSYCHIATRY
2000
140000
1000
120000
0
08-09
09-10
10-11
11-12
12-13
13-14
YEARS
NO. OF PATIENTS
NO. OF PATIENTS
5000
CHILD PSYCHIATRY
NEUROLOGY
NEUROSURGERY
100000
80000
60000
40000
20000
0
09-10
10-11
11-12
12-13
13-14
YEARS
DEATHS
PSYCHIATRY
CHILD PSYCHIATRY
NEUROLOGY
NEUROSURGERY
600
NO. OF PATIENTS
500
EXTENSION SERVICES
400
GUNJUR
GOWRIBIDANUR
MADDUR
KANAKAPURA MADHUGIRI SAKALAWARA TURUVEKERE
300
14000
200
12000
100
08-09
09-10
10-11
11-12
YEARS
12-13
10000
13-14
NO. OF PEOPLE
0
8000
6000
4000
2000
0
08-09
09-10
10-11
11-12
YEARS
12-13
13-14
Annual Report
I. MENTAL HEALTH SERVICES
Perinatal Psychiatry Clinic:
Newregistrations
Follow-ups
Mother-BabyUnitinpatientadmissions
PSYCHIATRY
A.
Clinical Services
Facilities provided
General Adult Psychiatry Services
Screening
Registrations
EmergencyServices
Follow-ups
Admissions*
Discharges
Deaths
Extension Services
Sakalawara
Gunjur
Gowribidanur
Maddur
Kanakapura
Madhugiri
Thuruvekere
Centre for Addiction Medicine
Newcases
Follow-ups
Admissions
Tele-consultations
Psychiatric Rehabilitation Services
Day-boarders-averagedailyattendanceto
allsections
In-patientreferralstoPRS
SERWICEpatientsconsultations(outpatientservices)
In-patientadmissions(Psychotherapy)
Electro-Convulsive Therapy (ECT)
services:
Newcases
Obsessive-Compulsive
(OCD) Clinic:
Newcases
Follow-ups
Schizophrenia Clinic
Totalcases
Geriatric Clinic
No.ofelderlyscreened
No.ofdetailedevaluation
No. of patients /
cases
2012-13 2013-14
101816
11883
2028
91240
5675
5234
07
217883
106227
12915
2330
95715
5850
5402
06
228445
5016
21564
12232
2185
5876
2937
2831
3431
549
30041
2516
9782
1107
8900
22305
2668
10218
1091
4837
18814
59
618
578
29
59
935
738
27
61
1345
44
1803
756
5779
6535
882
6512
7394
342
1536
430
1541
1878
1971
1521
1823
3200
375
3575
2986
517
3503
16548
Disorder
2013-14
Metabolic Clinic in Psychiatry
Totalcases
Telemedicine services:
Grand Total
B.
114
471
76
661
109
496
69
674
532
162
277961
469
671
295608
Diagnostic Services
Facilities provided
Toxicology services (Centre for Addiction
Medicine)
HPTLC-basedtests
GC-MS-basedtests
Cassette-basedtests
C.
Specialist Clinic Services
1.
Centre for Addiction Medicine
No. of patients /
cases
2012-13 2013-14
4593
6083
The Centre for Addiction Medicine (CAM) has completed
more than two decades of clinical service, training and
research in the area of addiction. During the year 2013-14,
the CAM registered 2668 new patients, and followed up
10218 patients face-to-face and 4837 via telephone. A total
of 1091 patients were admitted to the CAM inpatient ward
fortreatment.
The Centre offers a comprehensive inpatient programme
encompassing individual and family assessment, individually
tailoredtreatmentswhichinvolvepharmacologicaltreatments
forwithdrawalandlong-termpreventionofrelapse,individual
and group counselling, family counselling and intensive
aftercare.
Annual Report
2013-14
In response to the growing public demand for patient care,
public awareness, community activity, research and policy,
severalnewinitiativeswereinitiated,duringtheyearunder
review.The20-beddedinpatientfacilityforsubstance-using
women,thefirstofitskindinthe country,isalmostcomplete
andtheservicesareexpectedtostartfromJune2014.
Thedrug-toxicologylaboratory,whichtestedmorethan6083
samples for drugs and alcohol in urine and blood in the year
2013-14, has added one more e-machine for testing samples
tokeepupwiththegrowingdemand.Thelaboratoryhasbeen
receivingrequestsfromoutsideagenciesfortoxicologytests,as
itistheonlylabwiththisfacilityintheregion.
The CAM conducted several research studies on behavioral
addictions such as pathological gambling, internet and cell
phone addiction, etc. Various services for treating behavioral
addictionshavebeenstarted,basedontheresearchfindings.
Thegymfacility,startedlastyear,receivedgoodresponseand
isusedbypatientsonaregularbasis.
days. Facilities for altering the stimulus parameters are also
available. EEG monitored ECT is done in select cases, where
specificallyindicated.
3.
The Family Psychiatry Centre offers both outpatient and
inpatient family therapy services. The major services include
family therapy, marital therapy, and family intervention for
different psychiatric disorders. The centre conducts training
programmesfortraineesfromNIMHANSandotherinstitutes
across the country in the field of psychiatry, psychology,
psychiatry social work and nursing. Basic orientation course
andadvancedcourseinfamilytherapyarealsoofferedbythe
Centre. The faculty of the Centre were involved in organising
variousprogrammesonfamilytherapyindifferentpartsofthe
country.
Duringtheyear2013-14,atotalof441newfamilieswereseen
andmanymorecasesfromthepreviousyearwerefollowedup.
4.
CommunitysocialworkersoftheCAMteamcontinuedtoplay
avitalroleintheprocessofeducatingandbringingawareness
about addiction and recovery in the community. They were
alsoactivelyinvolvedinorganizingsubstanceabusecounselling
programmesandprovidingtreatmentfortheneedy.
“The Centre for Addiction Medicine, NIMHANS is doing
extraordinary service to substance users, by way of
combining knowledge with services, and research with
action. The centre has not limited itself to deliver quality
services, but also has developed into a centre of excellence,
having components of research, trainings, advocacy,
innovations and community outreach.”
– External evaluation of the Centre for Addiction Medicine
by Voluntary Health Association of India on behalf of the
Ministry of Health and Family Welfare, Govt. of India.
2.
Electroconvulsive Therapy (ECT) services
NIMHANS has a state-of-the-art, purpose built
Electroconvulsive Therapy (ECT) suite.The ECT multidisciplinaryteamconsistsofpsychiatrists,anesthetists,nurses,
and other dedicated staff members. During the year 2013-14,
a total of 882 new patients received ECTs. Total number of
ECTs received stood at 6512. Each patient undergoes a preECTevaluation.ECTservicesareprovidedonallOPDworking
Family Psychiatry Centre
Geriatric Clinic & Services
The elderly—above the age of 60 years—who register with
the screening outpatient service unit are screened for
neuropsychiatric disorders by the Geriatric Group of the
Department of Psychiatry. This is mainly to enable the
elderly to avail appropriate services and get referrals at a
faster pace. Approximately 15 to 20 elderly are screened
everyday.
GeriatricClinicisrunasaspecialmultidisciplinaryclinicinthe
DepartmentofPsychiatryonSaturdays,from2to5.30pm.The
team includes psychiatrists, neurologists, neuropsychologists,
social workers, residents, and trainees. On average, 8-10
new cases go through brief evaluation, and 4-5 elderly are
evaluated in detail—and about 10-15 follow-up patients are
seen—everyweek.Intheyearunderreview,272newcaseswere
registeredintheGeriatricClinic.Caregiversareprovidedwith
necessary support both as individual families and also as a
groupdiscussioneveryweek.
TheGeriatricGroupalongwiththeDepartmentofEpidemiology
is actively engaged in the sensitization programmes and
training of BBMP physicians in Bangalore. The Geriatric
GroupcollaborateswiththeNIMHANSCentreforWellBeing
to provide counselling for the needy elderly and necessary
assistance through the Elderly Helpline that was initiated in
2012.TheGeriatricGroupalsoworksactivelywiththeSenior
Annual Report
Citizen Forum in South Bangalore in promoting positive and
healthyageing.
5.
Obsessive-Compulsive Disorder (OCD) Clinic
The OCD clinic was started in 1997 with the objectives of
providing high quality clinical service, training mental health
professionals and facilitating research in the area of OCD.
Severely ill and/or treatment resistant patients with OCD are
routinelyadmittedtothewardsforintensivepharmacological
andpsychosocialintervention.
In the year 2013-14, a total of 430 new cases were registered
intheclinicandnumberoffollow-upvisitswas1541.Sixtysix
patients were admitted for treatment. Patients from various
parts of the country are often referred to the OCD clinic for
expertopinionandtreatment.
ThespecialtyOCDcliniciswidelyknowninthecountryforits
researchactivities.
6.
Schizophrenia Clinic
SchizophreniaClinicaimsatprovidingcomprehensivecarefor
schizophrenia patients. In addition to the ongoing services, a
new programme– ORACLES – Objective Risk Assessment
Care & Liaison for Early Schizophrenia has been initiated in
Schizophrenia Clinic with the support from the Wellcome
Trust / DBT India Alliance Senior Fellowship Grant with the
following objectives: Focussed early intervention services;
betterdelineationofcourseandprognosis;understandingthe
clinicalmarkersofmedicationresponse;identifyingthefamily
members at risk for close monitoring and care; identification
ofprodromalsymptomsandinterventionstopreventpsychosis
conversion; initiating early rehabilitation strategies and
individualtherapy;involvementoffamiliesintothetreatment/
careinadditiontoreductionofstigmaandexpressedemotions
byeducation/familybasedtherapies.
Intheyear2013-14,atotalof1823patientswereassessedand
treatedattheclinic.
7.
2013-14
Neurosurgery, Neuro-rehabilitation and other clinical
departments) and outpatients (referred from Neurology and
Neurosurgery departments) who availed the services stood at
265and252respectively.
The CLP has initiated two new outpatient services to attend
toreferralsandenhanceawarenessofmentalillnessamongst
patients with chronic chest diseases and diabetes—one at the
SDS Tuberculosis & Rajiv Gandhi Institute of Chest Disease,
Bangalore(where117referralswereattendedto),andtheother
attheNGO-fundedJnanaSanjeevaniMedicalCentre(Diabetes
clinic, where 96 referrals were attended to). Psychiatric care
wasalsoprovidedtopatientsfromNIMHANSCentreforWell
BeingbytheCLPteam.
CLPconductedseveraljointneuropsychiatriccasediscussions
in collaboration with the Dept. of Neurology. Between April
2013 and March 2014, the CLP Team has been involved in
various academic programs. Workshops were conducted to
enhance awareness of Mental illness and its role in physical
illness and well-being in SDS Tuberculosis & Rajiv Gandhi
Institute of Chest Disease, Bangalore and Jnana Sanjeevani
Medicalcentre.Additionally,aworkshopwasconductedbythe
CLP team on Breaking Bad News and Communication Skills
atNIMHANSforvariousMedicine,NeurologyandPsychiatry
residentspostedtotheCLPservice.
8.
Emergency Psychiatry and Acute Care (EPAC)
Services
TheEmergencyPsychiatryandAcuteCare(EPAC)servicesunit
provides24-hourcareforpatientspresentingwithpsychiatric
symptoms in emergencies. EPAC services were utilized by
6252patientsatanaverageof521patientspermonth,inthe
year under review. Structural modifications to the ward were
made to enhance patient care, safety and improve workplace
conditions. Identifying the need for care for specific patients,
EPAC has been involved in the planning, implementation
and initiation of a Priority Wards—SAFER Ward (Safety and
Facilitate Early Recovery) and ASIST Ward (Applied Suicide
Intervention, Support and Treatment)—to manage patients
withhighrisktoselfandothers.
Consultation Liaison Psychiatry Services
TheConsultationLiaisonPsychiatry(CLP)Serviceshaveseen
a significant increase in referrals, indicative of the enhanced
service and care offered by the CLP team to patients. In
2013-14, the number of inpatients (referred from Neurology,
The EPAC team has developed two separate risk monitoring
forms-RisktoSelfandRisktoothersandmodifiedtheCritical
IncidentReportingFormandCriticalIncidentReportingSOP
tofacilitateimprovementsinoverallqualitycareandminimize
thelikelihoodofadverseevents.
Annual Report
9.
2013-14
Community Psychiatry Services
The extension out-patient department/camp services of
Community Psychiatry NIMHANS was first started in 1978
at Sakalawara (Bangalore Rural) with the primary goal of
identifying mentalmorbidityandtreatingthemwiththehelp
ofprimarycarephysiciansworkingatcommunityhealthcare
centres.Itwasalsodonetoencouragecommunityparticipation
whichinturnwouldhelpinthereductionofstigmaassociated
withmentalillness.
has initiated revised special clinical assessment protocols
namely–METASCAN(METAbolicAssessmentinpsychoseS:
ClinicalAssessment&Neurobiology)withbaselineandfollowup versions with further optimizations. These protocols add
ontothetrainingandassessmentinputstotheresidentsand
enhancethefocusofclinicalapproach.
Number of patients assessed and treated at the Clinic during
theyear2013-14was469.
11.
In the decades that followed, many primary care physicians
weretrainedbyNIMHANSwiththegoalofintegratingcareof
thementallyillattheprimary/communitycarelevel.Extension
camps/clinics were opened in eight other places of the State,
takingthetotaltonine(Anekal,Gowribidanur,Gunjur,Jigani,
Kanakapura,Marsur,Maddur,MadhugiriandSakalawara).At
present, six extension camps are functioning with Jigani and
Marsurhavingbeenwithdrawn.
The team of Community Mental Health from NIMHANS,
consistingofpsychiatrists,clinicalpsychologists,psychiatricsocial
workersandnurses,havebeenprovidingthefollowingservices:
1.
2.
3.
4.
5.
6.
7.
8.
Consultationformentallyillpatientstoprovidediagnosis,
drug treatment and follow-up management of different
mentaldisorders.
Consultation for patients with epilepsy to provide
diagnosis,drugtreatmentandfollow-upmanagementof
differentseizuredisorders.
Referralservicesfordifficulttotreatortreatmentresistant
patientstoeitherNIMHANSoranyothernearbytertiary
carehospital.
IEC activities for the patient, family members and the
generalpublic.
Familyinterventionandhomevisits.
Behaviouralinterventions.
Disability assessment for mentally ill and mentally
retarded individuals (IQ assessment & Disability
Certification).
Training of other medical and nursing professionals in
theTalukhospitals
About2000patientsattendedinallthesixextensionclinicsper
month.
10.
The Metabolic Clinic in Psychiatry:
Continuing the focus on evaluating and treating metabolic
abnormalitiesinpsychiatry,theMetabolicClinicinPsychiatry
Genetic Counseling and Testing Clinic (GCAT)
The diagnosis of Ataxias and Huntington’s disease has a major
impact on people with the illness and on their families. An
accurate diagnosis is important so that the patient can be given
appropriate treatment. The GCAT team is involved in the pregeneticcounselling,genetictestingandpost-geneticcounsellingof
the patients whose neurological examination has been done by a
neurologistandconfirmedtoshowsymptomsofthedisease.Pre-
Genetic Counselling involves educating and counselling about the
implicationsofthetesting.Genetictestingundertakeninourlabis
accurate and reliable. Most people get a result which is definitely
normal or definitely abnormal. However, a small number of
peoplefallintoa“greyarea”betweenthenormalandtheabnormal
range.Post-geneticcounselinginvolvesdisclosureofresultsbythe
cliniciankeepinginmindthesensitivenatureoftheissue.About100
individualsandtheirfamiliesavailedtheservicesduringtheyear.
NIMHANS CENTRE FOR WELL BEING
Facilities provided
ConsultationLiaisonPsychiatry
MaritalEnrichmentServices
PreventiveServicesforAddiction
Family Enrichment Services, Premarital
Counselling,StressManagementforChildren
andAdolescents,ParentingTraining
StressManagementandLifestyleClinic
PositiveMentalHealthClinic
PsychologyClinic
Asare(ParentSupportgroup)
Grand Total
No. of patients/
cases
2012-13 2013-14
186
223
34
42
24
35
102
74
49
40
62
10
507
55
41
80
57
607
A. Clinical Services
i.
FLOURISH Clinic
TheClinicoffersone-to-oneconsultationservicetoadultsfor
enhancingtheirwell-beingandself-development.Itisrunona
Annual Report
weeklybasisbythePositivePsychologyUnitatNIMHANS.In
theyearunderreview, 42newclientshavebeenregisteredfor
receivingconsultationservices,andthenumberofsessionsper
clientrangedbetweenthreeandsixasusual.
ii.
Marital Enrichment Services
Atotalof57clientssoughtconsultationattheclinic.
iii.
Asare Services, NCWB
GroupSessionsforparentswereorganizedatAsare.Intheyear
underreview,62parentsparticipatedin18groupsessions.
iv.
Psychology Care Clinic, NCWB
About80newclientssoughthelpandwereprovidedwiththe
necessaryservicesattheclinic.
CHILD & ADOLESCENT PSYCHIATRY
A.
Clinical Services
Facilities provided
ChildandAdolescentPsychiatrycases
screened
Newfilesregistered
Follow-ups
Admissions
Causality&emergency
Grand Total
No. of patients/
cases
2012-13 2013-14
6489
7063
2453
15402
624
24968
2992
15240
509
57
25861
CLINICAL PSYCHOLOGY
A.
Clinical Services
Behaviouralmedicineintake
Behaviouralmedicinetherapy
Mentalhandicapcounselling
CAPcounseling,remediationandtherapy
Adultpsychotherapyandcounseling
Familyandmaritaltherapy
Psychosocialrehabilitationtherapy
CAMtherapies
Neuropsychologicalrehabilitationcognitiveretraining
Neurofeedbacktherapy
New services
Communitymentalhealthevaluation
Community mental health evaluation
(disabilitycertificate)
Communitytherapy
TBIevidenceinthecourt
DPNRevaluation
DPNRfollow-up
Generalhospitalassessment
Generalhospitalintake
Generalhospitaltherapyandcounselling
Grand Total
B.
Facilities provided
Evaluationofadultcases
Evaluationofaddictioncases
Follow-upofaddictioncases
AdultPsychiatryfollow-up
Follow-up:ChildandAdolescentsandMR
clinic
EvaluationofCAPcases
Evaluation of children and adolescents
withmentalretardation
Therapy/Interventions
997
89
380
5509
460
1100
175
410
7848
390
337
230
240
184
672
440
346
458
881
417
61
180
87
743
409
215
300
1159
382
69
195
105
140
86
153
-
321
195
108
9
290
112
5
231
86
12678
321
7
252
204
3
228
144
15685
Diagnostic Services
Facilities provided
2012-13 2013-14
PsychoDiagnosticAssessment
506
854
CAMassessment
72
60
Evaluationofchildandadolescentscases
337
392
Childandadolescentsassessment
400
392
Evaluationofmentalhandicapscases
391
184
Psychological assessment of Mental
500
601
Handicapcases
DPNRAssessment
34
27
Neuropsychologicalassessment
1803
1954
Communitymentalhealthassessment
187
354
AssessmentatJHMRC
16
15
Grand Total
4246
4833
C.
No. of patients /
cases
2012-13 2013-14
2013-14
Stress Management and Lifestyle ClinicattheNIMHANS
Centre for Well Being (NCWB) began its services in 2011. The
services are run by the Behavioural Medicine Unit and are
operationalonallFridayafternoons.Itisaimedatofferingstress
management services to people from different walks of life as
well as for those who require help in maintaining or achieving
healthier lifestyles. The services offered include suggestions for
stressmanagementssuchasrelaxation,identifyingandhandling
stressfulthoughts,lifestylechangeswithrespecttostress.Aseries
of workshops were conducted on academic stress, managing
interpersonal relationships, understanding social anxiety and
Annual Report
2013-14
work stress for the urban community at the NCWB. A total of
55clientssoughtconsultationattheclinicduringtheyearunder
review.
II. NEUROSCIENCES SERVICES
NEUROLOGY
A.
PSYCHIATRIC SOCIAL WORK
Facilities provided
TheDepartmentinitiatedapilotprogrammeofpsychosocial
services for the clients and families referred by the Child
Welfare Committee, which has resulted in a long-term
project with the Department of Women and Child Welfare
as a specific service to be carried out by the Department
of Psychiatric Social Work. About 67 clients were provided
withtheservicesofcounsellingandfamilyinterventionand
a few were referred back to the Department of Child and
Adolescent Psychiatry for further management of mental
healthproblems.
Facilities provided
No. of patients /
cases
2012-13
2013-14
CasehistoriesandMSE
6431
7713
Follow-upservices
15418
18515
Individual
6321
7586
Family
7985
9588
Groupinterventions
1862
1862
Rehabilitationandplacementservices
987
1184
Home/Agencyvisits
229
198
14581
17497
501
613
Schoolvisits
6
8
Extensionservicesandcamps
50
60
Otherpsychosocialrehabilitationservices
197
237
Psycho-educationservices
Correspondence
Disabilityassessment
1408
1689
Pre-dischargecounseling
961
1153
Supportiveintervention
6001
7203
Psychosocialassessment
5495
9180
Collateralcontact
1297
1557
Activityscheduling
836
6557
Presurgicalcounseling
142
152
Postsurgicalcounseling
168
180
12
3
Psychiatricsocialworkservicesincasualty
295
303
NIMHANSCenterforWellBeing
102
185
Freelegalaidservices
155
180
Schoolmentalhealthprogramme
Clinical Services
Registration
Follow-up
Admission
Discharge
Casualty(Emergency)
Deaths
Grand Total
B.
Diagnostic Services
Facilities provided
DigitalElectroencephalography(EEG)
VisualEvokedPotential(VEP)
BrainStemAuditoryEvokedResponse
(BAER)
SomatoSensoryEvokedPotential(SSEP)
VideoEEG(VEEG)
Polysomnography(PSG)
Electroneuromyography(ENMG)
Electrocardiogram(ECG)
Electrocorticography
Grand Total
C.
No. of patients/
cases
2012-13 2013-14
18665
20356
63809
68193
3599
4102
3288
3731
12367
19026
200
195
101928 115603
No. of patients/
cases
2012-13 2013-14
2832
3386
1032
1232
985
1195
1042
352
45
2376
1976
28
10668
1206
450
106
2483
2103
36
12197
Facilities provided
NeuroMuscular
Epilepsy
MovementDisorder
Dementia(intheGeriatricOPD)
Strokeward
Grand Total
No. of patients /
cases
2012-13 2013-14
673
743
610
458
231
203
140
495
38
1654
1937
Neuromuscular Disorders Clinic is a multidisciplinary
specialtyclinicrunonthefourthSaturdayofeverymonth.About
60-80patientswithvariousneuromusculardisordersvisitthis
clinic.GeneticanalysisforDuchenneMusculardystrophyand
SpinalmuscularatrophywithGeneticcounsellingisoffered.
Annual Report
Movement Disorders Clinic is held on the first and the third
Saturdaysofeverymonthandabout10to15patientsareseenon
thesedays.Deepbrainstimulation(DBS)isalsoofferedbytheClinic.
Geriatric ClinicisconductedonallSaturdaysexceptsecond
Saturday and about 10 patients with dementias of varying
aetiologyaswellastheircaregiversareseenandmanagedina
multidisciplinaryway.
CranialSupratentorial
Infratentorial
Spinal
Peripheralnerve
Cranial
Spinal
CranialAcute
CranialDelayed
CVJ
Spinal
Tumours
Infections
Trauma
Stroke ward encompasses five ICUs, five step-down and three
specialwards,whereasizeablenumberofpatientswitharterial,
venousstrokeareadmittedandmanagedthroughthrombolysis,
decompressivecraniotomyandotherprocedures.
Functionalsurgery
NEUROSURGERY
A.
Clinical Services
Facilities provided
Registration
Follow-up
Admission
Discharge
Casualty(Emergency)
Deaths
Grand Total
No. of patients/
cases
2012-13 2013-14
21649
20343
38527
39448
5499
6170
4817
5445
*13973
17103
513
540
71005
89049
* Daily OPD started from July 2012
B.
No. of cases
Vascularsurgery
Congenitalanomalies
Cranial
Spinal
Cranial
CVJ
Spinal
Peripheralnervesurgery
Chronicsubduralhematoma
DBS&Thalamotomy
Epilepsysurgery
MVDfortrigeminal
neuralgia
Radiofrequency
lesioningfor
trigeminalneuralgia
Drez
Endoscopicsurgery
StereotacticBiopsy
Brainbiopsy
Biopsy
Shunt
Craniotomyforstroke
Spinaldegenerativedisorder
GKRS
Miscellaneous(boneflap
replacement,cranioplasty,etc)
Emergencyproceduresdone
onbedsidelike(external
ventriculardrainage,twist
drilltapping,tracheostomy)
EpiduralSteroidInjection
Grand Total
2013-14
358
7
7
87
36
2013-14
888
300
127
6
111
23
444
25
3
115
60
270
19
51
39
49
1
41
94
4
525
97
348
280
309
1621
45
6390
NEUROANAESTHESIA
A.
Clinical Services
Facilities provided
Diagnostic Services
Type of surgery
No. of cases
Type of surgery
Epilepsy Clinic: About 20 to 30 patients with refractory
epilepsyareseenintheEpilepsyClinic,whichisheldonfirst
andthirdSaturdayofeverymonth.Treatmentplansaremade
for the patient; in addition, education regarding marriage,
employment, and free legal aid is provided. Free drugs are
distributedtodeservingpatients.
Aprotocolforacuteischemicstrokethrombolysisandvenous
stroke management has been prepared and is being utilized.
Patienteducationrelatedactivitiesandtrainingofparamedical
staffregardingtriageofacutestrokeisdone.
2013-14
Anaesthesiainoperationtheatres
a)Electiveoperations
b)Emergencyoperations
Total
Intensivecareunits
MedicalICU
SurgicalICU
EmergencyICU
Total
Grand Total
No. of patients/
cases
2012-13 2013-14
1892
2406
4298
1852
2996
4848
84
353
839
1276
5574
73
413
676
1162
6010
Annual Report
B.
2013-14
Diagnostic Services
Facilities provided
Neuroradiological procedure done under
sedation/GA
ModifiedECT
Grand Total
B.
No. of patients/
cases
2012-13 2013-14
1375
5340
6715
1609
6512
8121
C.
1.
Pre-anaesthetic check-up at the bedside for all elective
surgeries
Painclinicoffers:
a) Anaesthesia/sedation for radiofrequency lesion in
trigeminalneuralgia
b) Epiduralsteroidinjectionsforbackache
c) Lumbarpunctureindifficultcases.
2.
Clinical Services:
Facilities provided
Neuro-interventions
B.
No. of patients/
cases
2012-13 2013-14
149
122
Diagnostic Services:
Facilities provided
RoutineX-rayexaminations
Ultrasoundexaminations
ComputedTomographyScans
MagneticResonanceImaging
DigitalSubtractionAngiography
SPECTCT
Grand Total
No. of patients/
cases
2012-13 2013-14
21530
23467
3600
2411
38260
41114
10553
11099
1040
1236
144
265
75127
79592
SPEECH PATHOLOGY & AUDIOLOGY
A.
Therapysessions
Follow-upevaluation
SpeechLanguageEvaluation
AudiologicalEvaluation
No. of patients/
cases
2012-13 2013-14
4937
4314
1311
1389
III. REHABILITATION SERVICES
ThePsychiatricRehabilitationServices(PRS)areprovidedby
amultidisciplinaryteamcomprisingfacultyfromDepartment
of Psychiatry, Clinical Psychology, Psychiatric Social Work,
Nursing;juniorconsultants;seniorresidentsandpostgraduate
studentsfrombothwithinandoutsidetheInstitute.
PRS caters to rehabilitation needs of patients in various settings:
Day-care, inpatient, outpatient and referrals from psychiatry
inpatient units. PRS has various vocational sections including
baking,printing,computer,candlemaking,weaving,crafts,plasticmoulding,carpentry,horticulture,tailoring,leather,etc.forpatients.
A.
No. of patients/
cases
2012-13 2013-14
3120
5140
2401
2323
Clinical Services
Facilities provided
Averagedailyattendancetoallsections
In-patientreferralstoPRS
SERWICEpatientsconsultations
(out-patientservices)
In-patientadmissionsspecificallyfor
rehabilitationpurposes(unit4badmission)
Psychotherapy
Cognitiveretraining
Socialskillstraining
Otherinterventions
Grand Total
No. of patients/
cases
2012-13 2013-14
59
59
618
935
578
738
29
27
61
1345
44
14
5
20
1842
Clinical psychology trainees did detailed evaluation and file
reviewsof252patients,andfollowedup204patients.
B.
Clinical Services
Facilities provided
Facilities provided
PSYCHIATRIC REHABILITATION SERVICES
NEURO IMAGING & INTERVENTIONAL RADIOLOGY
A.
Diagnostic Services
Diagnostic Services
Facilities provided
IQAssessments
NeuropsychologicalAssessments
Others
No. of patients/
cases
2012-13 2013-14
33
22
12
15
1
5
Annual Report
C.
Home-based rehabilitation in collaboration with Hundred
Hands;andBanyanTreeAdvisors.
Services for Enhanced Recovery with Intensive and
Comprehensive Engagement (SERWICE)
SERWICE caters to the rehabilitation needs of patients with
severe mental disorders (schizophrenia, bipolar disorder,
severeobsessivecompulsivedisorder)andmentalretardation.
The patients are first evaluated in detail using the SERWICE
proforma (designed by the PRS team) keeping in mind their
overall rehabilitation needs. Then each patient is allotted to
one therapist (trainee). Under the supervision of PRS team
members, the trainee would then provide comprehensive
care for the patient till the time optimal functional recovery
is reached. The therapist would be the main contact /liaison
person for the patient. In addition to pharmacotherapy, the
therapistwouldbepivotalinprovidingahostofotherservices
including psycho-education, individual psychotherapy, family
therapy, cognitive retraining, vocational training, social skills
training, physiotherapy, training in self-help skills, learning
skills, behavioural modification, vocational counselling, etc.
Thetraineewouldliaisewiththerapistsfromvarioustreatment
units so that smooth co-ordination exists. This would also
ensure continuity of care. Support would be continued even
after patients get into vocation. Active efforts would be made
by the therapist to retain patients in follow-up. Sufficient
timeforoutpatientpsychosocialinterventionswouldbegiven
duringfollow-ups.TheadvantagesofSERWICEareasfollows:
(a) Longer consultation with their therapist (b) wide range
of evaluations important for their recovery (c) wide array of
interventions would be provided (d) contact with the same
mentalhealthprofessional(e)treatingteamtobecontactable
through phone and email. In addition to the clinical services,
theunitplanstoevaluateoutcomesofthefollowed-uppatients.
Intheyear2013-14,therehavebeen738consultationsinthe
SERWICE OPD. As on March 2014, 138 patients are being
followed up by MD/DPM residents under SERWICE and the
casesareperiodicallydiscussedwiththefacultyconcerned.
D.
2013-14
Special Initiatives for Patients
Active efforts are made to explore employment opportunities
for adequately trained patients attending Psychiatric
RehabilitationServices.Duringtheyear2013-14,atotalof13
candidates were placed in prominent organisations such as
Shankar Eye Hospital; Sun IT; HCL; Abilities in Disabilities;
CBR(settingupcomputers,photo-copying/Xeroxandprinting
shops); APD for Training & CBR in Horticulture Nursery;
Products from different vocational training sections like jute
mats, bamboo basket and lamp shades, wire baskets, colorful
candles, mats and bakery products were displayed and sold
at exhibitions. The PRS calendar and information leaflets
for patients and caregivers were also freely distributed at the
followingexpos:(a)GaneshafestivalcelebrationsatL&TSouth
City,Bangalore,on15September2013,organizedwithhelpof
a volunteer Mrs. Seema Sharma (b) A Handmade Collective
expoconductedbyAHundredHandsTrust,anon-profitTrust
on 29 November, 2013 at Kochhan Institute, Sivan Chetty
Gardens, Bangalore (c) 3rd Annual Conference of the Society
for Mitochondrial Research and Medicine (SMRM - 2013)
- “Mitochondria in Health and Disease, NIMHANS, 19-20
December2013.
Products from different vocational training sections like jute mats, bamboo
basket and lamp shades, wire baskets, colourful candles, mats and bakery
products being displayed and sold at an exhibition.
Special programmes for patients and family members:
Classes for patients/family
Healtheducation
Laughtertherapy
Mentalexercises
Sensorystimulation
Self-esteembuildingsession
Independentlivingskillsession
Skilldevelopmentprogram
ExhibitionsconductedinDPNR
Pooja-bhajansessions
Storytellingsessions
Craftsessions
Readingactivity
No. of sessions
53
48
47
47
47
128
34
7
37
42
36
34
Annual Report
2013-14
Classes for patients/family
Recreationalactivity
Meditationsession
Exercisesession
Picnic
Arts
No. of sessions
89
251
243
1
94
SanjeevaniVedikediscussionsessionsontopicssuchasMental
illnessanditsimplications;Cognitivedeficitinmentalillness;
Problems of elderly caregivers of mentally ill; Dealing with
stigma;Suicideprevention;Cognitiverehabilitation;Prevention
and management of diabetes type 1 and 2; Importance of
rehabilitationformentallyillperson;Managementofmentally
ill in social situation; and Welfare benefits for patient and
familymemberswereorganisedbyDPNR(thirdMonday,every
monthatrecreationhall).
Consultations and ward-admissions
in Neuro-Rehabilitation division
Grand Total
ii.
No. of patients /
cases
2012-13 2013-14
11316
10457
Para-medical Services (Physiotherapy,
Occupational Therapy and Orthotics)
Out-patient services: Physiotherapy section
Activities
Total no. of patients/ treatment sessions
2012-13
2013-14
New
Total
New
Total
Referral treatment Referral treatment
OPD
NDT
Balanceand
gaittraining
NeuromuscularClinic
Total (OP
patients)
4204
6228
3618
5922
1840
2640
1861
2446
107
-
1004
602
9
65
480
480
6151
10474
5959
8848
In-patient services: Physiotherapy section
Total no. of patients/ sessions
Stations
Patients attending psychiatric rehabilitation services actively took part in various
cultural events held as part of Independence Day, Republic Day, Ayudha Pooja
and Christmas celebrations at the Institute.
DEPARTMENT OF NEUROLOGICAL REHABILITATION
A.
Clinical Services
i.
Medical services:
No. of patients /
cases
2012-13 2013-14
Numberofnewreferrals
9644
8281
Numberoffollow-ups
933
1329
Numberofadmissions
186
223
Numberofdischarges
190
214
Number of health education sessions
70
70
conducted
Classesfortrainees
18
12
Neuro-muscularClinic
275
328
Consultations and ward-admissions
in Neuro-Rehabilitation division
Rehabilitation
MICU&SICU
Strokeward
EICU
Otherwards
Stepdown
ward
Total(IP
patients)
Grand total
(IP &OP)
2012-13
2013-14
New
Total
New
Total
Referral treatments Referral treatments
132
3632
187
3866
120
6712
270
6692
68
1688
57
1707
444
7888
304
7797
1196
8544
1500
5841
-
-
98
799
1960
28464
2416
26702
8111
38938
8375
35550
Services provided at occupational therapy section
Total no. of Patients
Sessions
2012-13
2013-14
No.ofNewPatients
2517
2922
- Follow-upsessions
10068
11688
- Treatmentsprovided
44100
46752
ADLsessions
1812
1416
- Treatmentprovided
3624
2832
MultisensoryTherapy
- No.ofsessions
193
212
Neuro-muscularClinic
275
419
Annual Report
Services provided at occupational therapy section
Total no. of Patients
Sessions
2012-13
2013-14
EducationalCD’ssold
4
Robotichandrehabilitation
16
Totalno.ofsessions
240
Grand Total
62589
66501
Services provided by orthotic section
No. of Devices
made
Appliances
2012-13
2013-14
Totalnumberofbeneficiaries
224
177
Totalno.ofappliancesmade
414
359
Numberofrepairsandfollow-upsdone
06
06
No.offollow-ups
15
13
Grand Total
659
555
B.
Diagnostic Services
Facilities provided
Uro-dynamicstudies
C.
No. of patients /
cases
2012-13 2013-14
71
73
ii.
The Department of Neurological Rehabilitation runs the
Neuromuscular Clinic in association with the Department of
NeurologyonfourthSaturdayofeverymonthinthemainOPD
building.Ateamconsistingofconsultants,residentdoctorsand
paramedical staff (physiotherapists, occupational therapists
andorthotists)takecareofrehabilitationneedsofthepatients
with neuromuscular disorders. More than 250 patients
benefittedfromtheseservicesduring2013-14.
IV. LABORATORY SERVICES
NEUROCHEMISTRY
Diagnostic Services
i.
Plasma, Serum and CSF investigations
Parameters
Albumin
AlkalinePhosphatase
Ammonia
BilirubinTotal
Calcium
Chloride
Cholesterol
Creatinekinase
Creatinine
CSF-Sugar/Protein/Chloride
Gammaglutamyltransferase
Glucose
HDL-Cholesterol
Lactatedehydrogenase
Lithium
Osmolality
Phosphorous,inorganic
Potassium
SGOT(AST)
SGPT(ALT)
Sodium
Totalprotein
Triglycerides
Urea
UricAcid
RoutineBiochemistryfrom
outsidereferral
Total
2012-13
13609
45518
3341
45467
2013-14
25577
44829
3343
45578
2013-14
9244
76694
6994
5361
60009
7348
2447
73231
6948
3136
4906
4368
7546
69583
45551
45009
69583
13785
6850
59538
1005
8446
79215
7362
6329
58462
6730
2351
69566
7283
3005
4638
4193
6136
72239
44998
44969
72230
24145
7240
57369
1247
47
77
687148
707527
2012-13
355
32
NA
NA
522
522
2
1875
253
407
410
422
43
818
735
354
1353
1852
6
6
76
320
2595
2013-14
515
42
42
49
589
589
13
1555
214
318
562
597
46
1277
1274
317
2063
2874
5
12
70
223
2414
Special investigations
Parameters
Angiotensinconvertingenzyme
AnticardiolipinAntibodiesIgA
AnticardiolipinAntibodiesIgG
AnticardiolipinAntibodiesIgM
AntiphospholipidAntibodiesIgG
AntiphospholipidAntibodiesIgM
AntiThrombin
APTT
ArylSulfataseA
Carbamazepine
Ceruloplasmin
Copper
Fibrinogen
Folate
HbA1c
Hexosaminidase,total,A&B
Homocysteine
Lactate
LupusAnticoagulant
Microalbumin
Phenobarbitone
Phenytoin
ProthrombinTime
Annual Report
2013-14
Parameters
Protein-C
Protein-S
T3
T4
ScreeningforIEMbytandem
massspectrometry
TSH
Valproate
VitaminB12
SpecialInvestigationfromoutside
referral
Total
iii.
2012-13
7
7
6141
6142
2663
6594
617
2371
102
37602
2013-14
24
24
7780
7787
3558
8160
851
4209
39
48092
Urine investigations
Parameters
24HoursUrinaryProtein
Abnormalmetabolitesscreeningtest
BenceJonesprotein
Copperin24hoursurine
Homocystinuria
MPSspottest
Myoglobinuria
Osmolality
Porphobilinogen
Urobilinogen
AbnormalMetabolitesfrom
outsidereferral
Total
2012-13
37
1782
395
250
8
24
19
4448
402
2
90
2013-14
24
1903
601
304
11
11
30
4326
581
4
35
7457
7830
Summary
Diagnostic facilities provided
Totalnumbersofroutineinvestigations
Totalnumbersofspecialinvestigations
Total
No. of Tests
2012-13 2013-14
687148
715397
45059
47811
739664 771038
NEUROMICROBIOLOGY
Diagnostic Services
Sl.
No.
1
2
3
4
Facilities provided
CSFcellcount
CSFcytology
CSFcultures
Puscultures
No. of patients/cases
2012-13
6290
828
3026
115
2013-14
6021
1440
2782
113
Sl.
No.
Facilities provided
Routinecultures
Fungalcultures
AFBcultures
SerumASLOdeterminations
CRPdeterminations
Serumwidaltest
Serumrheumaticfactortest
BloodVDRL
CSFVDRL
CSF–antimycobacterial
antibodytestbyELISA(MTSE)
15 CSF-mycobacterialimmune
complexofIgGtype
16 CSF–mycobacterialimmune
complexofIgMtype
17 CSF-anticysticercalantibody
usingAntigen-B
18 IndiainkforCryptococci
19 Mantouxtest
20 Serumantinuclearantibody
test
21 CSFlatexagglutinationtestfor
Cryptococcalantigen
23 Serum/CSFToxoplasmatestby
latexagglutination
25 Koch’sspine
26 Bloodcultures
27 Oligoclonalbandand
monoclonalgammopathy:IgG
IgA
IgM
28 Anti-acetylcholinereceptor
antibodies:Direct
29 Vitek-2Compact-60
30 BACTECMGIT
31 BACTALERT
Investigations – Hospital
Infections Surveillance
System
31 Bloodbanksterilitycheck–
NIMHANS
32 CSSDsterilitycheck
33 OTsterility
34 Wateranalysis
36 Screeningofothersites:
Throat,Axilla,Groin
38 MRSAscreening
39 MDRGNB
42 RedCrossBloodbagsterility
Grand Total
5
6
7
8
9
10
11
12
13
14
2012-13
2013-14
6431
2371
2076
47
103
334
2121
3507
2398
2538
6223
2733
2412
52
103
332
2731
4093
2638
2495
2538
2495
2538
2495
2538
2495
2416
192
2118
2648
123
2659
81
46
12
42
34
767
443
443
443
09
890
511
511
511
175
206
229
345
7934
591
878
1050
400
468
44
66
49
382
25
29
28
254
2289
40
712
59413
2138
920
56190
2013-14
Annual Report
NEUROPATHOLOGY
Diagnostic Work
A.
Clinical Services
i.
Transfusion Medicine Centre
Neurology
Facilities provided
Bloodandbloodcomponentscollected
Smallvolumeplasmapheresis
Largevolumeplasmapheresis
BloodgroupingRhtyping
Blooddonationcampsheld
Phlebotomy
Grand Total
ii.
iii.
B.
i.
2012-13 2013-14
13642
14589
241
361
1297
2386
46073
50134
68
73
137
132
61458
67675
2012-13 2013-14
46,327
48,863
11,370
9,784
861
706
17,052
17,001
1,379
1,195
58
279
23
114
95
97
119
103
54
57
18
14
5,288
5,310
184
124
163
273
82,991 83,920
Autopsy service
Autopsies
ClinicalAutopsies
MedicolegalAutopsies
Grand Total
2012-13 2013-14
18
19
296
329
314
348
47
06
47
53
Muscle
458
916
1295
1374
Nerve
144
1169
1262
1313
Skin
91
132
197
223
Liver
-
11
12
11
36
45
63
81
442
461
865
903
887
1362
1844
2249
181
63
298
244
Brainbiopsy
Muscle-
Histochemistry
Immunohistochemistryfor
TumourDiagnosis
Muscle
Immunohistochemistry
Grand Total
ii.
Neuropathology
No.ofBiopsies
Neurosurgical
2013-2014
TOTAL
2012- 2013NIMHANS REFERRALS
13
14
2706
4630
7108 7336
1830
1986
4233
7698
13425 19872 21123
Electron Microscopy - Common Research Facility
Facilities
provided
No. of cases
2012-13
Ultrastructural
studies
2013-14
385
382
NIMHANS Referral NIMHANS Referral
A. Diagnostic
Electron
Microscopy
B. Research
Samples
submittedfor
lightmicroscopic
studies(Semithin)
96
112
100
130
90
87
102
50
30
26
Department of Neuropathology: Summary of tests
done
Diagnostic Services
Diagnostic Work
TOTAL
2012- 2013NIMHANS REFERRALS
13
14
876
2644 2648 3520
StereotacticBiopsy
Clinical Pathology
Investigations carried out
Hemogram
PeripheralSmear
PeripheralSmearforMP
ESR
BT/CT
AEC
ANC
ReticulocyteCount
SicklingTest
SalineDilutionTest
BoneMarrowStudy
UrineExamination
StoolExamination
ResearchProject
Grand Total
2013-2014
1
2
3
4
Section
Histopathology
TransfusionmedicineCentre
ClinicalPathology
Electronmicroscopy
Grand Total:
Number
21,120
67,675
83,920
408
1,73,123
3816
2013-14
Annual Report
NEUROVIROLOGY
Facilities provided
Diagnostic Services
Facilities provided
2012-13
2013-14
Laboratory diagnosis of
JapaneseEncephalitis
Dengue
Chikungunya
Rabies
Measles
HSV
Enterovirus
H1N1
HIV
CD4
Earlyinfantilediagnosis(EID)
HIVviralload
HepatitisB
Grand Total
213
919
219
213
173
821
24
3137
4605
11,053
4043
287
979
26686
260
781
301
266
249
408
25
542
4771
15,019
3868
938
1033
28461
NEUROPHYSIOLOGY
B.
Diagnostic Services
Facilities provided
Samplessenttodifferentlaboratoriesfor
variousinvestigationsfromthefollowing
areas:
NeuroCentrewards
PsychiatricwardsincludingCasualtyand
EmergencyServices
Grand Total
C.
Diagnostic Services
No. of patients/
cases
2012-13 2013-14
54780
48482
211315
129866
103262
341181
Details of the services provided to the clients from
April 2013 to March 2014
Facilities provided
AutonomicFunction
Evaluation
PulmonaryFunction
Evaluation
Grand Total
2012-13
2013-14
714
857
474
388
1188
1245
V. SUPPORTIVE SERVICES
NURSING
A.
Homevisits
OPDServices,ExtensionClinics
Grand Total
No. of patients/
cases
2012-13 2013-14
98
110
24470
22486
148001
142515
Clinical Services
Facilities provided
Acutenursingcare
Intensivenursingcare
ECTs
EmergencyNursingCare
Neurology
Neurosurgery
Psychiatry
Chronicpatientcare
No.ofsurgeriesassisted
CommunityMentalHealthServicesprovided
Newcases
Oldcases
No. of patients/
cases
2012-13 2013-14
10229
11391
9183
12746
5775
6492
27600
25562
8847
7392
4375
28046
24516
9114
13830
4907
3167
21303
2557
6320
DropinenquiriesandTelephonicenquiries
Totalregisteredclients
NumberofclientsconsultedCLP
Number of clients seen by Stress mgt and lifestyle
managementteam
NumberofclientsseenbyMaritalEnrichmentService
team
Number of clients seen by Family enrichment/
Parenting training/ Student & Adolescent Stress
management/OccupationalStressmanagementteam
NumberofclientsseenbyPositivePsychologyteam
NumberofclientsseenbyDe-addictionteam
NumberofclientsseenatPsychologyclinic
Asare(Parentsupportgroup)
Grand Total
1206
521
223
55
42
74
41
35
80
67
2344
VI. AYUSH SERVICES
AYURVEDA
Hospital Services
Outpatientservicesareofferedonaregularbasisatthemain
OPD block of NIMHANS. Patients with various neurological
and psychiatric disorders are provided with specialised
consultationsandtreatment.Numberofpatientstreatedduring
2013-14atOPDandIPDareasfollows:
Annual Report
Follow
EmergenAdmissions Discharges Death
Up
cies
4524 5697
300
303
00
00
New
Special Clinics & Services
1.
A special clinic is held on fourth Saturday of every
monthinassociationwiththeDepartmentofNeurology.
Ayurvedicmedicationsareprovidedandimprovementsin
healthconditionsofpatientsareassessedthroughregular
follow-ups.Duringthereportingyear,684patientswith
neuromusculardisordersweretreated.
2.
AspecialGeriatricOPDisbeingrunbytheInstitute,every
Tuesdays.ThedataofpatientswhoattendedtheGeriatric
OPDduringthereportingyearisasfollows:
Number of patients attended
New
Old
Grand Total
Male Female
Male
Female Male
Female
417
286
698
488
1115
774
Advanced Centre for Yoga - Mental Health and
Neurosciences
The Advanced Centre for Yoga - Mental Health and
Neurosciences was started in 2007 in collaboration with the
Morarji Desai National Institute of Yoga, New Delhi (funded
by the Department of AYUSH, Govt. of India) for promoting
training and research in Yoga. Activities of the centre were
essentially interdisciplinary involving all clinical and many
basicsciencedepartments.
TheCentrecompletedthetermoffiveyearsin2012.However,in
viewofunutilizedgrantsandneedforcompletionoftheresearch
workcarriedoutbytheCentre,aone-yearextensionwasgranted.
TheCentreiscurrentlyofferingyogaservicestopatientswiththe
helpofaYogatherapistservingoncontractbasis.
Yoga Therapy Services
TheCentrehasbeenofferingYogatherapyforoutpatientsand
inpatientssince2008.Followingaretheclinicalservicesoffered
topatientsreferredfromotherdepartmentsofNIMHANS.
•
•
•
Yogatherapyservicesforpsychiatric&neurologicalpatients
Regular Yoga sessions at Child & Adolescent Psychiatry
Unit,NIMHANS.
RegularYogaclassesforinpatientsatpsychiatricwardsof
NIMHANSthroughtrainednursingstaff.
•
2013-14
Regular Yoga sessions for caregivers of patients with
psychiatric&neurologicaldisorders.
In the year 2013-14, a total of 13154 Yoga (patient) sessions
werecarriedout—8225foradultsand4929forchildren.Total
number of sessions for new patients stood at 1688 (974 for
adultsand497forchildren)
Yoga Therapy at Child & Adolescent Psychiatry Unit
About 500 children received Yoga therapy in the children’s
wards, along with their caregivers, at the Child & Adolescent
Psychiatry Unit, as part of the part routine ward activities
carriedoutbytheYogaCentre.
Yoga Sessions at Psychiatry Wards
The Centre is alsorunning daily yoga classes at different
psychiatric wards through nursing staff trained in Yoga. A
yoga-based session with selected yogic asanas, pranayama
and nadanusandhana techniques has been introduced in
place of unstructured physical activity at both open and
closed psychiatric wards. An average of about 15-20 patients
participateintheseyogabasedsessions.
VII. OTHER SERVICES
HUMAN GENETICS
Genetic counselling is provided to patients (and their family
members) with various genetic disorders including brain and
nervous system tumors, Down syndrome, Turner syndrome,
DMD, osteogenesis imperfect-brittle bone disorder, mental
retardation, Robertsonian syndrome, polyhydramnios,
mitochondrial disorder, metabolic disorders such as
metachromaticleukodystrophy.Premaritalcounsellingservices
arealsooffered.Onlinegeneticcounsellinghasalsobeenmade
availableforconvenienceandgreateranonymityofthepatients.
Atotalof40patientsandtheirfamilymembersbenefitedfrom
thegeneticcounsellingservicesduringtheyearunderreview.
Karyotypingtestingwasperformedon16patients.
MENTAL HEALTH EDUCATION
The Department in collaboration with the Departments of
Neurosurgery, Nursing, Psychiatric Social Work and Clinical
Psychology developed a set of educational/informational
brochures for people with head injury and their caregivers.
Theseinclude:
Annual Report
•
•
•
•
2013-14
Head Injury – Discharge Information for Patients and
Carers
HeadInjury–PsychosocialAspects
HeadInjury–CaringforCarers
Neurosurgery – Advice on Discharge for Health
Professionals
The Department designed posters on identification of mental
disorderslikedepression,OCD,andBipolarAffectiveDisorder.
Each poster illustrates various symptoms associated with the
illnesswhichcouldhelpinidentifyingthedisorder.Posterson
first aid in epilepsy and identification of stroke and the need
fortimelytreatmentwerealsobroughtout.Theposterscanbe
usedbyfacultyandstudentsofvariousdepartmentstoeducate
publicandcommunity.
Photographic and Video Services
Other specialised services of the Department include
photography and video documentation and development of
healtheducationvideosandvisualmaterials.
In the year under review, 1027 requests for photographic
services (650 for still photography and 377 for videos) were
received. As many as 24735 photographs (17172 for clinical
and training purposes, and 7563 for administrative purpose)
were taken during the period, a decrease of about 20percent
compared to the previous year. Due to the usage of PAX, the
number of photographs of radiological images has greatly
reduced.
Majority of the requests were from the Department of
Neurology (for a total of 2723 digital photographs) and
Department of Neurosurgery (for 1853 photographs). A total
of 7563 photographs of Institute functions, administration,
documentation, and other activities were taken. A record of
photosofallimportanteventsandfunctionsismaintainedand
providedfordocumentationandpresentationontheInstitute
Day. Expenditure on printing photographs has also reduced
considerably.Photoalbumswerepresentedtodignitarieswho
gracedimportantfunctionsoftheInstitute.
Atotalof377requestsforvideoswerereceived,ofthese227videos
wereedited.Forthefirsttime,chromakeytechniquewasusedin
studio recording to insert visuals as background. In addition to
the clinical videos, videos depicting various services and facilities
availableintheinstituteweremade.Thevideosandhealtheducation
clipswereshownonCCTVintheOPD.Videodemonstrationsand
roleplaysfortrainingandacademicprogrammesandfordeveloping
teachingandtrainingmaterialswerealsoontherise.
Video clips for CCTV, Outpatient Department:
1.
2.
3.
4.
5.
6.
7.
8.
ProperuseofhelmetinEnglishandKannada
FirstaidinEpilepsy
OnlineRegistration
OPDandscreeningservices
CasualtyandEmergencyServices
InformationaboutNCWB
Medicationpouchmanufacturedbypatientsofpsychiatric
rehabilitationinkannada,EnglishandHindi
Artworkbychildrenofchildpsychiatrycentre
Annual Report
2013-14
Annual Report
2013-14
Human Resource Development
A. POSTDOCTORAL FELLOWS
1.
2.
3.
4.
5.
6.
Dr.SugnyaniDevi,Child&AdolescentPsychiatry
Dr.KrishnaPrasadM,AcuteCareandEmergencyPsychiatry
Dr.BijuViswanath,AddictionMedicine
Dr.DeepakJayarajan,AddictionMedicine
Dr.SatishRasaily,AddictionMedicine
Dr. Ajish Gopinath Mangot, Clinical Neurosciences &
TherapeuticsinSchizophrenia
7.
Dr.NikhilJain,CommunityMentalHealth
8. Dr.VikramSinghRawat,ConsultationLiaisonPsychiatry
9. Dr.MalvikaRavi,ConsultationLiaisonPsychiatry
10. Dr. Easha Sharma, Obsessive Compulsive Disorder &
RelatedDisorders
11. Dr.NiveditaPatra,Neuroinfections
12. Dr.AbuZafarAnsari,Neurology(MovementDisorders)
13. Dr.PrajnaRanjaniM,NeurologicalRehabilitation
14. Dr.DheerajA,NeurologicalRehabilitation
15. Dr.DSathiyaBama,Neuropathology
16. Dr.AshaU,Neuropathology
Ph.D
1.
Biostatistics (1)
Ms. PTSubha
2.
Clinical Psychology (7)
Ms. AaratiTaksal
Mr. AbdulSalamK.P
Ms. HesiS.Herbert
Ms. MahimaSukhwal
Mr. RavikeshTripathi
Ms. SelviM
Ms. UttaraChari
3.
3.
4.
Neurochemistry (1)
Mr. MathewJohn
Neurological Rehabilitation (1)
Ms. PradnyaRajeshDhargave
Neurophysiology (6)
Mr. ChristoferThomas
Dr. HarshaHN
Dr.
Dr.
Dr.
Mr.
5.
Neurovirology (2)
Ms. VijayalakshmiR
Ms. PrachiRahulFadnis
6.
7.
8.
B. QUALIFICATIONS AWARDED
I.
9.
Karnataka
Delhi
Kerala
Kerala
Rajasthan
UttarPradesh
TamilNadu
AndhraPradesh
MeghanaA
RavikiranKisan
SajishChandran
SaravananS
Nursing (2)
Ms. KNJayanthi
Ms. NKusuma
Karnataka
Karnataka
Kerala
TamilNadu
Karnataka
Maharashtra
Karnataka
Karnataka
Psychiatric Social Work (6)
Mr.AnishVCherian
Ms.DianaRoss
Mr.SJeyaram
Mr.JimmySebastian
Mr.SanjeevKumarManikappa
Mr.SUbaharaSahayaraj
Karnataka
Kerala
TamilNadu
Kerala
Karnataka
TamilNadu
Psychiatry (3)
Dr.HariprasadVR
Dr.LakshmiNarayananK
Dr.GVenkatasubramanian
Karnataka
TamilNadu
TamilNadu
Speech Pathology & Audiology (1)
Mr.PradeepY
II.
DM (Neurology)(5)
Dr.AdwaniSikandarGokuldas
Dr.GovindarajuC
Dr.PradeepKallollimath
Dr.SaileshModi
Dr.ESenthilKumar
Karnataka
Maharashtra
Karnataka
Karnataka
AndhraPradesh
TamilNadu
III. DM (Neuroradiology) (2)
Dr.GudipatiAnantaRam
Dr.ParamveerSinghSabharwal
AndhraPradesh
Uttarkhand
Kerala
IV. M.CH (Neurosurgery) (6)
Maharashtra
Kerala
Karnataka
Dr.MehulNavinchandraModi
Dr.PrakashMahantshetti
Dr.PraveenKumarFSaligoudar
Dr.RakshithKumarShettyAB
Dr.RamanMohanSharma
Dr.SudheeshRamachandran
Gujarat
Karnataka
Karnataka
Karnataka
UttarPradesh
Kerala
Annual Report
V.
MD (Psychiatry) (20)
Dr.GayatriSaraf
Dr.HemendraSingh
Dr.JitendraRohilla
Dr.KapilJhamnani
Dr.KavitaNagpal
Dr.KumbharMaheshAnandarao
Dr.SMahavirAgarwal
Dr.PrabhuKiran
Dr.PunithM
Dr.RashmiA
Dr.SabariSridharOT
Dr.SaravanaKumarA
Dr.ShahDharavSunil
Dr.ShashidharaHN
Dr.ShreeMishra
Dr.SissiraVS
Dr.SunilKumar
Dr.SureshVC
Dr.VinuthaR
Dr.VirupakshaHS
VIII. M. PHIL (Neurophysiology) (2)
Maharashtra
Rajasthan
Rajasthan
Rajasthan
Delhi
Maharashtra
Orissa
Karnataka
Karnataka
Karnataka
TamilNadu
TamilNadu
Maharashtra
Karnataka
Maharashtra
Kerala
Karnataka
Karnataka
Karnataka
Karnataka
VI. DIPLOMA (Psychiatry) (6)
Dr.HarshitHemantSalian
Dr.KulkarniGajanan
Dr.LakshmiS
Dr.NaveenRGowda
Dr.SuneethaKS
Dr.VirupakshappaIrappaBagewadi
Karnataka
Karnataka
Karnataka
Karnataka
Karnataka
Karnataka
VII. M.PHIL (Clinical Psychology) (16)
Ms.AnjaliSudhindran
Ms.DeeptiGuruprasad
Ms.DivyaVSalian
Ms.InduSMenon
Ms.IndupriyaB
Ms.LavanyaTP
Ms.LeeshmaK
Ms.LynElsaGeorgy
Ms.NaphisabetKharsati
Ms.PrateekshaVShetty
Ms.RinshaEK
Ms.SeemaPNambiar
Ms.ShynimolKB
Mr.SiddharthDutt
Ms.SystlaRukminiPatanjali
Ms.VaisnvyNM
2013-14
Kerala
Karnataka
Maharashtra
Kerala
Kerala
Karnataka
Kerala
Kerala
Meghalaya
Karnataka
Kerala
Kerala
Kerala
Karnataka
WestBengal
TamilNadu
Mr.SureshKumarParmar
Mr.VijayaKumarK
AndhraPradesh
Karnataka
IX. M.PHIL (Neurosciences) (4)
Ms.AditiDeviN
Ms.IngridDianaMonteiro
Ms.RanganayakiS
Dr.ShaileshKumarGupta
Karnataka
Maharashtra
TamilNadu
UttarPradesh
X.
M.PHIL (Psychiatric Social Work) (17)
Mr.BGAnantharamu
Mr.AnoopSyriyac
Ms.BhuvaneshwariB
Mr.BibinVP
Ms.Chaithra
Ms.ChithranjaliKV
Ms.DahunlyneShylla
Ms.DivyaBallal
Mr.IjasAbdulMajeed
Ms.JaniceSebastian
Ms.JunaB
Ms.ManjushaWarrierG
Ms.ParamitaBhowmick
Ms.SajithaK
Ms.ShiniC
Mr.Shrinivasa
Mr.Virupaksha
Karnataka
Kerala
TamilNadu
Kerala
Karnataka
Kerala
Meghalaya
TamilNadu
Kerala
Kerala
Kerala
Kerala
WestBengal
Kerala
Kerala
Karnataka
Karnataka
XI. M.Sc. (Psychiatric Nursing)(8)
Ms.AnnieJohnP
Mr.MKathiravan
Ms.PoornathaR
Ms.RRajalakshmi
Ms.RashmiN
Ms.KSugavanaselvi
Ms.TaniaMarinaThomas
Ms.VijayalakshmiM
Kerala
TamilNadu
Karnataka
TamilNadu
Karnataka
TamilNadu
WestBengal
TamilNadu
XII. B.Sc. (Nursing) (36)
Ms.AnjaliSaji
Ms.AnjalyKThomas
Ms.AnjanaSebastian
Ms.AnjuJoseph
Ms.AnuBabu
Ms.AnuJose
Ms.AnumolJames
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Annual Report
2013-14
Ms.AshwiniV
Ms.AswathySajeev
Ms.AthiraJoy
Ms.DellaPJose
Ms.DivyaMaryJacob
Ms.GiftyMolAntony
Ms.HPrarthanaHariet
Ms.HarshaBiju
Ms.HealaRoseBaby
Ms.HemalathaM
Ms.JeslinMariaJose
Ms.JessyMolJoseph
Ms.JibyJacob
Ms.JincyJoseph
Ms.JintuKBabu
Ms.LinshyAlex
Ms.NeethuBaby
Ms.NeethuSunnyA
Ms.NimmyJoy
Ms.ParvathyRajagopal
Ms.RemyaRaveendran
Ms.RosminMathew
Mr.ShahidAK
Ms.ShaniKuriakose
Ms.SharonKA
Ms.ShimnaJohn
Ms.SijimolS
Ms.SujithaKS
Ms.VimalJyothyJohn
Karnataka
Kerala
Kerala
Kerala
Kerala
Karnataka
Karnataka
Kerala
Kerala
Karnataka
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
TamilNadu
TamilNadu
Kerala
XIII. B.Sc. (Radiography) (2)
Mr.RoshanAntony
Mr.SujitKumarSingh
Mr. AbhishekPaul
Ms. JeslitKJoy
Ms.PriyaElsaJohn
Department of Clinical Psychology (1)
Ms.CathlynNiranjanaBennett
WestBengal
Kerala
Kerala
II.
DM (Neurology) (1)
Dr.RohanRMahale
Karnataka
Maharashtra
III. DM (Neuroradiology) (1)
Dr.ChandrajitPrasad
Bihar
IV. MD (Psychiatry) (2)
Dr.ImonPaul
Dr.SushmaBR
V.
DIPLOMA (Psychiatry) (2)
Dr.NitturkarAbhishekRavindra
Dr.VirupakshiJalihal
WestBengal
Karnataka
Karnataka
Karnataka
VI. M.PHIL (Biophysics) (1)
Ms.LataChaunsali
Uttarakhand
VII. M.PHIL (Mental Health & Social Psychology) (2)
Mr.FirdousAhmadWar
Ms.SwatiVasanthSapkale
Jammu&Kashmir
Maharashtra
Ms.LishaTBalan
Ms.JasmineMaryLyngdoh
Ms.RoshiniC
Ms.ThusathSatheesanSneha
Kerala
Meghalaya
Kerala
Kerala
IX. M.PHIL (Psychiatric Social Work) (1)
Ms.EktaJChheda
Maharashtra
M.Sc. (Psychiatric Nursing) (1)
Ms.AnnieRuhmahAustin
C. QUALIFICATIONS AWARDED
IN-ABSENTIA AT THE 18TH
CONVOCATION
Kerala
XI. B.Sc (Nursing) (8)
PhD
Department of Biostatistics (1)
Ms.MKarunambigai
TamilNadu
Department of Psychiatry (1)
Dr.BhavaniShankaraB
X.
I.
Karnataka
VIII. M.PHIL (Clinical Psychology) (4)
Kerala
AndhraPradesh
XIV. B.Sc. (Anaesthesia Technology) (3)
Department of Neurochemistry (1)
Ms.RenjiniR
TamilNadu
Ms.AleenaCPrince
Ms.AnuTomson
Ms.AshlyAbraham
Ms.LakshmiRajan
Ms.LiniVThomas
Ms.LittyPThomas
Kerala
Kerala
Kerala
Kerala
Kerala
Kerala
Annual Report
Ms.ManasaThomas
Ms.SilpaThomas
Neuroinfections (1)
Dr.NiveditaPatra
Kerala
Kerala
Neurological Rehabilitation (2)
Dr.PrajnaRanjaniM
Dr.DheerajA
POST-DOCTORAL FELLOWSHIP
Child & Adolescent Psychiatry (1)
Dr.SugnyaniDevi
Karnataka
Acute Care & EmergencyPsychiatry (1)
Dr.KrishnaPrasadM
Karnataka
Kerala
Karnataka
Sikkim
Sikkim
Consultation Liaison Psychiatry (2)
Dr.VikramSinghRawat
Dr.MalvikaRavi
TamilNadu
Karnataka
DIPLOMA (Clinical Neurophysiology
Technology (DCNT) (2)
Ms.NeethuCV
Mr.StevenB
Kerala
Karnataka
III. POST-BASIC DIPLOMA
(Psychiatric / Mental Health Nursing) (5)
Clinical Neurosciences & Therapeutics in
Schizophrenia (1)
Dr.AjishGopinathMangot
Maharashtra
Community Mental Health (1)
Dr.NikhilJain
UttarPradesh
Karnataka
Karnataka
Neuropathology (2)
Dr.DSathiyaBama
Dr.AshaU
II.
Addiction Medicine (3)
Dr.BijuVishwanath
Dr.DeepakJayarajan
Dr.SatishRasaily
Odisha
Neurology (Movement Disorders) (1)
Dr.AbuZafarAnsari
D. QUALIFICATIONS AWARDED AT
THE INSTITUTE DAY CELEBRATIONS
I.
2013-14
Mrs.BinduKP
Ms.JaishriSudamraoGathe
Maj.NKalpana
Mrs.SavithaP
Mrs.JThamayanthi
Kerala
Maharashtra
TamilNadu
Kerala
TamilNadu
IV. POST-BASIC DIPLOMA
(Neuro Science Nursing) (3)
Rajasthan
Maharashtra
Obsessive Compulsive Disorder & Related Disorders (1)
Dr.EashaSharma
UttarPradesh
Capt.AnuZacharia
Capt.SerahMathai
Mrs.TanySebastian
Kerala
Maharashtra
Kerala
Ph.D Candidates under External Fellowships
as on 31.03.2014
DEPARTMENT
Basic Sciences Division
Biophysics
Biostatistics
HumanGenetics
Neurochemistry
Neuromicrobiology
Neurophysiology
Neurovirology
Psychopharmacology
Behavioural Sciences Division
ClinicalPsychology
PsychiatricSocialWork
Psychiatry
Neuro Sciences Division
Neurology
ClinicalNeurosciences
TOTAL
CSIR
UGC
ICMR
DST
DST-Inspire
OTHERS
TOTAL
1
1
3
2
5
1
-
3
2
4
4
-
1
1
1
1
1
-
1
2
1
2
2
2
4
3
1
4
3
6
8
7
14
4
3
1
3
6
-
5
3
1
-
-
4
6
14
12
15
16
14
22
22
35
1
4
1
39
1
22
115
Annual Report
CSIR
UGC
ICMR
DST -Inspire
DST
Total
2013-14
2009 2010 2011 2012 2013
01
04
04
02
02
06
08
07
05
05
08
09
09
01
01
01
01
06
09
19
21
19
Total
13
21
36
03
01
74
E. OTHER COURSES
Diploma in Clinical Neurophysiology
Technology (DCNT)
1.
2.
Ms.NeethuCV
Mr.StevenB
II.
Post-Basic Diploma in Psychiatric / Mental
Health Nursing
1.
2.
3.
4.
5.
Mrs.BinduKP
Ms.JaishriSudamraoGathe
Maj.NKalpana
Mrs.SavithaP
Mrs.JThamayanthi
Kerala
Karnataka
Kerala
Maharashtra
TamilNadu
Kerala
TamilNadu
III. Post-Basic Diploma in Neuro Science Nursing
Capt.AnuZacharia
Capt.SerahMathai
Mrs.TanySebastian
F
Kerala
Maharashtra
Kerala
II.
Sl
No
A
B
01.
02.
Courses offered at NIMHANS
Sl
No
1
2.
3
4
Name of the Course
Neuroanaesthesia
B.Sc.(AnaesthesiaTechnology)
NIIR
B.Sc.Radiography
RadiographyTraineecourse
Neurology
Diploma(Diplomainclinical
NeurophysiologyTechnology-DCNT)
Nursing
DiplomainPsychiatricNursing(DPN)
DiplomainNeuroNursing(DNN)
B.Sc.Nursing-Iyear
IIyear
IIIyear
IVyear
PassedOut
8
7
A total of 1,287 students from outside Institutes attended
various training programmes (of periods ranging from
15-30 days) at the Department of Nursing to gain clinical
experience.
OTHER TRAINING
I.
Psychiatry
Diploma(Psychiatry-2013-14)
Diploma(Psychiatry-2012-2013)
Atotalof26nursingpersonnelattendedthetrainingonHIV/
AIDSunderGFATMprojectduringtheyearunderreview.
I.
1.
2.
3.
5
Number of
Candidates
15
25
22
03.
06
22
6
76
74
63
26
42
Students from other Institutions coming
to NIMHANS for training
Stream
No. of
TOTAL
Candidates
INTERNATIONAL
Clinical Psychology
NATIONAL
Biophysics
MSc(BiochemicalTechnology)
B.TechBiotechnology
IntegratedBSc.-MSc.course
MD(Psychiatry)
MD(Pediatrics)
DM(Neurology)
DNB(Psychiatry)
DNB(Pediatrics)
DPM(Psychiatry)
MPH(CM)
DCH(Paediatrics)
MBBs,FCPS(Psy),FRCP
M.Sc.Psychosocial
Rehabilitation
MPhilinMedical&Social
Psychology
M.Sc.(Nursing-Psy)
Clinical Psychology
MD
DNB
DMRadiology
DMNeurology
MD/DPM
DPM
Medical&Paramedical
MSSurgery
MBBS
Ph.D.
M.Phil.
M.Phil.ClinicalPsychology
3
3
1
1
1
123
65
9
4
11
2
11
1
6
1
9
3
1
199
72
3
1
1
1
1
40
1
2
3
31
7
Annual Report
Sl
No
Stream
M.Tech
(IntegratedM.TechProgramin
CognitiveNeuroscience)
M.A
04.
05.
06.
3
M.Sc.(PsychiatricNursing)
4
Epidemiology
13
Fellowship(CommunityHealth)
5
Human Genetics
4
B.Sc.(Biotechnology)
65
BE/B.Tech(Biotechnology)
9
Neuroanasthesia
10.
13.
122
3
37
MD
7
PhD
2
M.Tech
1
B.Tech
6
14.
15.
20
1
Neuro Imaging & Interventional
Radiology
MD/DNB/Diploma/Mch/
151
DMNeurology
M.Sc/MPT-Physiotherapy
35
B.Sc/BPT/BOT-
Physiotherapy,Occupational
Therapy
Neurology
55
76
MD/MS
11.
125
Neurochemistry
M.Sc.
09.
78
M.Sc./M.Tech.(Biotechnology)
BE
08.
18
MD(CommunityMedicine)
B.Sc.(AnaesthesiaTechnology)
Sl
No
12.
28
M.Sc.
MD/MS
07.
No. of
TOTAL
Candidates
1
151
16.
166
418
17.
399
MBBS
01
M.Sc.
02
B.Sc.
16
Neuromicrobiology
30
MBBS
1
M.Sc.Genetics
1
M.Sc.Neurobiology
1
M.Sc.Microbiology
15
M.Sc.Biochemistry
2
M.Sc.AppliedMicrobiology
2
M.Sc.MLT
5
M.Sc.Biotechnology
3
18.
Stream
Neuropathology
DM,M.Ch,MD-Pathology,
DM-NeuroRadiology
MBBS
M.Tech
M.Tech.(Cognitive
Neurosciences)
BE(Biotechnology)
M.Sc.(MLT)
M.Sc.(Biochemistry)
M.Sc.(Microbiology)
B.Sc.Nursing
B.Sc.Anesthesia
StaffNurses
Neurophysiology
Ph.D.
MBBS
B.Tech.(Biotechnology)
M.Sc.(Zoology)
Neurosurgery
M.Ch
MSGeneralSurgery,ENTand
DNB,FacioMaxillaryetc.,
Neurovirology
MD
BEBiotechnology
M.Sc.
Nursing
M.Sc.Nursing
PostBasicDiplomainNursing
P.CB.Sc.Nursing
BasicB.Sc.Nursing
B.Sc.Nursing
G.N.M
DPN
Psychiatry
MD
MBBS
Diploma(Psychiatry)
Psychiatric Rehabilitation
MD(Psychiatry)/DPMexternal
M.PhilPsychiatricSocialwork
–External
M.Sc.(Nursing)-external
B.Sc.(Nursing)-external
Diploma(Nursing)-external
PCBasicBScNursing
M.Phil.
MSW
Visited
2013-14
No. of
TOTAL
Candidates
425
219
63
01
01
05
2
01
01
96
3
31
9
4
1
3
1
179
34
145
66
60
5
1
1287
620
2
202
85
222
145
11
227
148
62
17
1011
24
172
538
179
5
93
620
1
155
464
Annual Report
Sl
No
19.
20.
2013-14
No. of
TOTAL
Candidates
Psychopharmacology
20
M.Pharma
8
M.Tech
2
B.Tech
3
BE(Biotechnology)
7
Speech Pathology & Audiology
144
PDF
2
MS(ENT)
44
DM(ChildPsychiatry)
2
BE(Biomedical)
17
B.Sc(Speech&Hearing)
79
Stream
Number of trainees who underwent training at
the Institute:
A total of 3795 students from various government/private
institutionsacrossthecountryvisitedandunderwenttraining
atNIMHANSduringtheperiod1April2013to31March2014.
Enriching psychosocial competencies among children
through NGOs in South India. Investigators: Dr. K.
Sekar (Funding by EveryChild India)
NIMHANS EveryChild project on “Enriching Psychosocial
CompetenciesamongchildrenthroughNGOsinSouthIndia”
initiatedsince2008aimstoprovidepsychosocialcompetency
in an integrated manner with education development
interventions for children living in difficult circumstances
throughNGO’sofEveryChildIndia.
The project has successfully completed the core objectives
of (a) profiling the psychosocial status of children in difficult
circumstances intervened by NGO’s and supported by
EveryChild India (b) developing appropriate intervention
strategies for building psychosocial competencies among
children living in difficult circumstances (c) capacity building
through TOT training program and cascading training by
NGO trainers at community level (d) providing supportive
supervision for the trained staff (e) Developing systems for
periodicalmonitoringandevaluation.During2013-14towards
institutionalization of psychosocial care activities, a tenday residential training programme, from 20-29 June 2013,
was organised at NIMHANS for the psychosocial counselors
from five NGOs supported by EveryChild India and Training
programmes (by master trainers) on psychosocial care for
children in difficult circumstances; life skills education for
children in difficult circumstances; enriching family life; and
student enrichment program for community-level workers
(CCAC teachers), Anganwadi and Asha workers are being
conductedonaregularbasis.
Intervention with children
A total of 7360 children benefited through the programme
carried out by five NGOs. As many as 1129 children were
identified to be at high risk, 598 children were provided with
additional support and 461 children were linked to various
socialprotectionschemes.
Psychosocial care for children with disability and
integrating into CBR approach for children with
disability in Karnataka.
NIMHANS -Sama Project on Psychosocial Care for Children
withDisabilityandIntegratingintoCBRApproachforChildren
withDisabilityinKarnatakaaimsatadaptingandintegrating
four psychosocial modules for children with disability with
special focus on physical disability and visual disability. The
totalfundingforthisprojectfromChristoffelBlindenMission
(CBM)isthroughSamaFoundation.
Special Programmes
The sensitization programmes (five workshops held) were
conducted to enlist the support and cooperation of partner
NGOs.Thefourmodules,namely:PsychosocialSocialCare,Life
SkillsEducation,StudentEnrichmentProgramandEnriching
Family Life were adapted for children with visual disabilities.
After adapting the modules, select staff members of select
NGOs were trained (four training programmes conducted) to
provide psychosocial care to children with a specific kind of
disabilitythroughparticipatorymethodologies.Afterreceiving
training, these staff members conducted the activities with a
largernumberofchildrenintheirselectedfieldareas.
Field-based handholding support was provided to 64 units
involving 80 direct participants by experts from NIMHANS
andSamaFoundation.
AYURVEDA
The Ayurveda Unit was involved in imparting training and
providingexposureontreatmentmethodologyandpanchakarma
techniques in the management of neurological and psychiatric
disorderstotheundergraduatestudentspostedtotheunit.
Annual Report
2013-14
Annual Report
2013-14
18th Convocation & Institute Day 2014 Awardees
Dr. Sailesh Modi
Silver Jubilee Awardfor
thebestoutgoingstudent
inDMNeurology-2013
Dr. Gudipati Ananta Ram
Golden Jubilee Award
forbestoutgoingstudent
inDMNeuroradiology-
2013
Dr. S. Mahavir Agarwal
Dr. Praveenkumar F.
Saligoudar
Dr. Sudheesh Ramachandran
Silver Jubilee Award for
thebestoutgoingstudentin
M.ChNeurosurgery-2013
Ms. Deepti Guruprasad
Dr. Lakshmi.S
Silver Jubilee Award for
thebestoutgoingstudentin
MDPsychiatry–2013
Dr. D.L.N. Murthy Rao
Memorial Prizeforthebest
outgoingstudentinDiploma
inPsychiatry-2013
Dr. M.V. Govindaswamy
Memorial Prizefor
scoringthehighestmarksin
M.PhilClinicalPsychology
-2013
Ms. Shini .C
Mr. Suresh Kumar Parmar
Mr. Vijaya Kumar .K
Ms. Lata Chaunsali
Dr. M.V. Govindaswamy
Memorial Prizefor
scoringthehighestmarks
inM.PhilPsychiatricSocial
Work–2013
Dr. R.N. Moorthy
Awardforscoringthe
highestmarksinM.Phil
Neurophysiology-2013
Ms. R. Rajalakshmi
Dr. R.N. Moorthy
Awardforscoringthe
highestmarksinM.Sc.
PsychiatricNursing-2013
Dr. Adwani Sikandar
Gokuldas
Dr. Anisya Vasanth
Memorial Award for
theBestPost-Graduate
ResidentinNeurology
-2013
Maj. N. Kalpana
Dr M. V. Govindaswamy & Dr D.L.N.
Murthy Rao Memorial Prize &
Infosys Foundation Award for
Excellence (inCash)forSecuringthe
HighestMarksinPost-BasicDiploma
inPsychiatric/MentalHealthNursing
ExaminationheldinApril2013
Dr. R.N. Moorthy Award
forscoringthehighestmarks
inM.PhilBiophysics-2013
Ms Neethu C.V.
Best Out-Going Student in
DiplomainClinical
NeurophysiologyTechnology
(DCNT)Course
intheyear2013
Capt. Anu Zacharia
Infosys Foundation Award for
Excellence(inCash)&Mukund
Memorial Award(inCash)forSecuring
DistinctioninPost-BasicDiplomain
NeuroScienceNursingExamination
heldinApril2013
Annual Report
2013-14
Conference / Symposia / Workshops
I.
Scientific Programs Organized at NIMHANS
A.
International
Dr. Uma H, Professor of Clinical Psychology, conducted
Symposium on Attachment Issues: Indian Perspective.
InternationalConferenceof7thCongressofAsianSocietyforChild
andAdolescentPsychiatry&AlliedProfessionsand12thBiennial
ConferenceofIndianAssociationforChildandAdolescentMental
Health,27September2013.30membersparticipated.
Dr. Mathew Varghese, Professor & Head of Psychiatry Dept.,
Dr. Sanjeev Jain, Professor of Psychiatry, Dr. Vivek Benegal,
ProfessorofPsychiatry,jointlyorganizedtheICMR-NIMHANSMRC UK Mental Health Scoping Workshop on Aetiology and
life-course of substance misuse and relationship with mental
illness,26-28February2014.40 membersparticipated.
Dr.MallaBhaskarRao,ProfessorofNeurosurgeryandDr.Sanjib
Sinha,AdditionalProfessorofNeurology,conductedInternational
ColloquiumonDrugResistantEpilepsyinPsychiatryDSM-V,1618August2013.500membersparticipated.
B.
National
Dr. P Marimuthu, Additional Professor, and Co-PIs of the
project conducted National Workshop on Migrants’ Access to
PublicHealthFacilitiesandHealthSystemResponse,15May
2013.15membersparticipated.
CHILD AND ADOLESCENT PSYCHIATRY
Dr. Satish C Girimaji, Professor & Head, Dr. Shiva Shankar
N, Professor & Head of Speech Pathology and Audiology,
conducted State Seminar on Early Intervention and Issues of
ViolenceandSexual HarassmentofPersonswith Disabilities,
23November2013.60membersparticipated.
CLINICAL PSYCHOLOGY
Dr. Anisha Shah, Professor & Head, conducted National
Workshop on Adult Psychotherapy- Emotion - Focused and
Constructivist Approaches, 5-7 October 2013. 20 members
participated.
Dr. Ahalya Raguram, Professor, Dr. Seema Mehrotra,
Additional Professor, conducted National Workshop on the
Research Survey and Exploration in Psychology (6th ICSSR
Survey) with ICCSR collaboration, 21 September 2013. 30
membersparticipated.
BIOSTATISTICS
Dr. K Thennarasu, Professor, Dr. Mariamma Philip, Sr.
ScientificOfficer,conductedNationalWorkshoponStatistical
MethodsinMedicalResearchandIntroductiontoSPSS,11-13,
July2013.54membersparticipated.
Workshop on Statistical Methods in Medical Research and Introduction to SPSS
Dr.PMarimuthu,AdditionalProfessor,Dr.MariammaPhilip,
Sr. Scientific Officer, conducted National Refresher Course
in Statistical Methods for Behavioral Research – 2013, 29-31
August2013.32membersparticipated.
Dr. LN Suman, Professor, and Dr. Veena Satyanarayana,
AssistantProfessor,conductedDepartmentalWorkshop(i)for
Counselors on Relationship Skills, 5 June 2013. 24 members
participated (ii) for Counselors on Work Effectiveness, 4
September2013.11membersparticipated(iii)forCounselors
on Counseling for the Elderly, 9 October 2013. 6 members
participated (iv) for Counselors on Counselor Wellness, 11
December 2013. 15 members participated. (v) for Counselors
on Psychological Counseling: Concepts, Skills and Ethical
Issues,26March2014.29membersparticipated.
Dr.LNSuman,Professor,conducteddepartmentalWorkshop
on Orientation to Forensic Psychology for PhD Scholars in
ClinicalPsychology,29October2013.12membersparticipated.
Dr. Seema Mehrotra, Additional Professor, conducted (i)
DepartmentalWorkshopforYouthonFeelingGoodandDoing
Well:AnExperiential,6-9May2013.16membersparticipated
(ii) Trainer’s Workshop on Feeling Good and Doing Well:
A Promotive Intervention Module, 24-26 June 2013. 41
Annual Report
2013-14
members participated (iii) Youth Pro Orientation Program, 8
August2013.24membersparticipated(iv)GoforYourGoals:
WorkshopforYoung Adults,17December 2013.30members
participated(v)AdvancedlevelTrainer’sWorkshoponFeeling
Good and Doing Well: A Promotive Intervention Module for
Youth,16-18December2013.18membersparticipated(vi)Go
forYourGoals:WorkshopforYoungAdults,6March2014.35
Dr. M Manjula, Associate Professor and Meghna Singhal,
PhD Scholar, conducted Workshop on Maintaining Healthy
Interpersonal Relationships for Youth, NCWB, 12 November
Dr. Seema Mehrotra, Additional Professor, Dr. Prabha S
Chandra,ProfessorofPsychiatryconductedinterdepartmental
NationallevelYouthConferenceonYouthProActionLabs,9
December2013.250membersparticipated.
Dr. M Manjula, Associate Professor, Mr. Vidhyasagar, PhD
Scholar and Ms. Seema Nambiar, PhD Scholar, conducted
WorkshoponEmotionRegulationforHealthyLiving,NCWB,
21December2013.18membersparticipated.
Dr. Jamuna Rajeswaran, Additional Professor, conducted
National Workshop on 4th Continuing Education in
Neuropsychology-Neuropsychological Rehabilitation Emerging
Hope: EEG- Neurofeedback Training (EH-NFT), 18-20
November2013.45membersparticipated.
Dr. M Manjula, Associate Professor, conducted workshop on
FacingExamsEffectively,NCWB,1March2014.13members
participated.
Dr. Paulomi M Sudhir, Additional Professor, conducted
departmental workshop on Understanding and Managing
SocialAnxiety,5October2013.13membersparticipated.
Dr.PaulomiMSudhir,AdditionalProfessor,Dr.MahendraP
Sharma, Professor and Dr. M Manjula, Associate Professor,
conducted departmental workshop on Cognitive Behavior
Therapy:ApplicationsinEmotionalDisorders,15-16November
Dr. M Manjula, Associate Professor, and Ms. Meghna
Singhal, Ph. D Scholar, conducted Parenting Teenagers/
YoungAdults:AworkshopforParents,NIMHANSCentrefor
Well-Being(NCWB),Bangalore,22June2013.11members
participated.
Dr.MManjula,AssociateProfessor,Dr.ManojKumarSharma,
Associate Professor, Dr. Poornima Bhola, Associate Professor
and Dr. Roopesh, Assistant Professor, conducted National
workshop on (i) Making a Difference: A workshop on Youth
MentalHealthforCollegeCounselors,25June2013(ii)Making
aDifference:AworkshoponYouthMentalHealthforCollege
Counselors,11-12July2013.48membersparticipated.
Dr. M Manjula, Associate Professor, Dr. Paulomi M Sudhir,
Additional Professor and Dr. Mahendra P Sharma, Professor,
conducted Workshop on Cognitive Behavior Therapy: Basic
Principles and Applications, 13-14 August 2013. 60 members
participated.
Dr. M Manjula, Associate Professor and Ms. Mareena Susan
Wesley,PhDScholar,conductedWorkshoponHandlingExams
Effectively,NCWB,7December2013.13membersparticipated.
Dr.DevvartaKumar,AssociateProfessor,Dr.PoornimaBhola,
AssociateProfessor,Dr.PriyaSaxena,conducted(i)Orientation
Programme: Orientation to Clinical Psychology: Emerging
areas, 26-27 November 2013. 22 members participated. (ii)
National Orientation to Clinical Psychology: Emerging Areas,
3-4December2013.22membersparticipated.
Dr. Poornima Bhola, Associate Professor, conducted
departmental workshop on (i) Tuning in: Being a reflective
psychotherapist,NCWB,4April,2013.20membersparticipated
(ii)ConsultationLiaisonClinicalPsychologybytheSt.John’s
Medical Hospital Team, 29 August 2013 and 5 September
2013.70membersparticipated(iii)Mirror,MirrorontheWall:
Becoming a Self-Reflective Practitioner, NIMRCPSYCH 2014:
2ndJointConferenceofNIMHANSandRCPSYCHUK:Training
andLearningforthe21stcenturytraineeinPsychiatry,9March
Dr. Poornima Bhola, Associate Professor and Dr. Ahalya
Raghuram,Professor,conducteddepartmental Symposiumon
WalkingtheLine:EthicalIssuesinPsychotherapyPractice,2627November2013.95membersparticipated.
Dr. Roopesh BN, Assistant Professor, conducted Workshop on
ManagementofDefianceandConductProblemsinChildrenand
Adolescents-ATreatment,25June2013.25membersparticipated.
EPIDEMIOLOGY
Dr. Gururaj G, Professor & Head, Dr. Senthil Amudhan R,
Assistant Professor and Dr. Girish N, Additional Professor,
Annual Report
2013-14
conducted National interdepartmental workshop on
Developing a District Roadmap for Integrated Child Mental
HealthServices,26February2014.19membersparticipated.
Dr. Girish N, Additional Professor, conducted (i) Training
programme for Counselors under National Programme for
Cardiovascular diseases, Diabetes, Cancer and Stroke, 20-22
August 2013. 19 members participated (ii) Interdepartmental
workshop on Elders Fortnight 2014, 21 September 2013-10
October2013.100membersparticipated(iii) Commemorating
International Women’s Day, 11 March 2014. 35 members
participated (iv) Refresher cum Training Programme for the
StakeHoldersoftheFamilyCounselingCenters,18-19March
2014. 48 members participated (v) Workshop on Capacity
StrengtheningforincludingNursingCareforGeriatricMental
Health Issues in District Hospitals, 25-26 March 2014. 43
Dr. Girish N, Additional Professor, Dr. Senthil Amudhan
R, Assistant Professor, Dr. Sunitha Singh, Jr. Scientific
Officer, conducted interdepartmental workshop on Research
Methodology-2013, 18-21 December 2013. 33 members
participated.
Dr. Pradeep BS, Associate Professor, conducted
interdepartmental stakeholders workshop on Understanding
Issues Among Youth in Karnataka, 26 March 2014. 105
Inauguration of Symposium on Mental, Neurological, Substance Use Disorders
and Injuries in Workplaces
HUMAN GENETICS
Dr. Chetan GK, Additional Professor, conducted DST
PAC meeting, 20-21 March 2014. 12 experts, 45 delegates
participated.
MENTAL HEALTH EDUCATION
Dr. Jayashree Ramakrishna, Professor & Head and Dr. KS
Meena, Assistant Professor, Department of Mental Health,
in collaboration with Lady Health Visitors Training Centre,
Vani Vilas Hospital, Bangalore, conducted (i) State-level
WorkshoponIntroductiontoHealthEducationforMentaland
NeurologicalDisordersforLadyHealthVisitor[LHV]Trainees,
22-26July2013.22membersparticipated(ii)onedaytraining
inMentalHealthEducationfortwonursingstudentswhohad
comeforCommunityMentalHealthTrainingfromthePunjab.
NEUROANAESTHESIA
Dr. V Bhadrinarayan, Professor, Dr. K Sriganesh, Associate
Professor,Dr.VSudhir,AssistantProfessor,conductedState-level
Workshopon Beorate,7-9March2014.100membersparticipated.
Stakeholders Workshop on Understanding Issues Among Youth in Karnataka
Dr.GauthamMS,AssistantProfessor,Dr.GururajG,Professor
&Head,conducted InterdepartmentalSymposiumonMental,
Neurological, Substance Use Disorders and Injuries in
Workplaces,31October2013.180membersparticipated.
Dr.MRadhakrishnan,AdditionalProfessor,Dr.SrinivasBabu,
ProfessorofPhysiologyinCMC,Vellore,conductedWorkshop
on Intraoperative Evoked Potential, March 31 2014. 30
NEUROCHEMISTRY
Dr. Gayathri N, Professor of Neuropathology, Dr. Srinivas
BharathMM,AdditionalProfessor,Dr.ChandrashekharSagar
BK, Additional Professor of Neuropathology, conducted 2nd
Annual Report
2013-14
AnnualHands-onWorkshopinNeurochemistryandElectron
Microscopy,15-20July2013.17membersparticipated.
WorkshoponPilates,BalanceandGait,SwissBall,19January
Dr. Gayathri N, Professor of Neuropathology, Dr. Srinivas
Bharath MM, Additional Professor, conducted (i) PreConferenceWorkshoponOROBOROSO2konHigh-Resolution
Respirometry and O2K-Fluorometry – IOC83, conducted by
Prof. Gnaiger Erich, OROBOROS Instruments, Innsbruck,
Austria,18December2013.20membersparticipated.
NEUROLOGY
Dr.ANalini,Professor&Headandfacultyofthedepartment,
conductedWorkshoponMERT,19October2013.350members
participated.
NEUROMICROBIOLOGY
NIIR
Dr. AK Gupta, Professor & Head, Stanley Prasanna Kumar,
Sr. Radiographer, P Ramachandra Reddy, Sr. Radiographer,
Ashwath Narayan Rao J, Sr. Radiographer, A Sanjay, Sr.
Radiographer, LM Prakasha, Radiographer, Siddalinga
Swamy KM, Sr. Radiographer, Deshpande BN, Radiographer,
Venkataramanappa G, Radiographer, conducted CME on
Advanced Imaging Techniques-2013, 12 May 2013. 220
Dr. AK Gupta, Professor & Head, Dr. Hima Shriniwas
Pendharkar, Associate Professor, Dr. Arvinda HR, Associate
Professor,Dr.JitendraSaini,AssistantProfessor,Dr.RoseDawn
Bharath,AssociateProfessor,Dr.ChandrajitPrasad,Assistant
Professor, Dr. Maya D Bhat, Assistant Professor, conducted
16th Annual Conference of Indian Society of Neuro Radiology
ISNR2013-AnInterdepartmentalScientificProgramme,2629September2013.500membersparticipated.
Dr. R Ravikumar, Professor & Head, conducted IAMM-KC
Quarterly Scientific Meeting, 19 October 2013. 65 members
participated.
NEUROPATHOLOGY
Dr. Gayathri N, Professor of Neuropathology, Dr. Yasha TC,
Professor & Head of Neuropathology, Dr. Vani Santosh,
Professor of Neuropathology, Dr. BKC Sagar, Additional
ProfessorofNeuropathology,Dr.AnitaMahadevan,Additional
Professor of Neuropathology, Dr. Anupam Gupta, Additional
Professor of Neurological Rehabilitation, conducted 3rd
Annual Conference of the Society for Mitochondrial Research
and Medicine - Mitochondria in Health and Medicine, 19-20
December2013.102membersparticipated.
Inauguration of 3rd Annual Conference of the Society for Mitochondrial Research
and Medicine
Dr. Gayathri N, Professor, conducted International PreConference Workshop on High Resolution Respirometry
(O2K),18December2013.20membersparticipated.
16th Annual Conference of Indian Society of Neuro Radiology ISNR 2013
NEUROLOGICAL REHABILITATION
Dr.PradnyaDhargave,Sr.Physiotherapist,Mr.SelvaGanapathy,
Physiotherapist, Mr. T Karthikeyan, Physiotherapist, Mr.
Rajesh VL, Physiotherapist, conducted Post Conference
Dr. Gayathri N, Professor, Dr. BK Chandrasekhar Sagar,
Additional Professor, Dr. MM Srinivas Bharath, Additional
ProfessorofNeurochemistry,conducted2ndNationalHands-on
WorkshopinNeurochemistryandElectronMicroscopy-2013,
15-20July,2013.12membersparticipated.
Annual Report
2013-14
Dr. Sundar Periyavan, Professor, conducted (i) National
WorkshoponBombayBloodGroup, 7July2013.25members
participated (ii) Regional Workshop on Blood transfusion
Reaction, 17 August 2013. 30 members participated (iii)
Preconference Workshop of 2nd national conference of Indian
Society of Transfusion Medicine, on Therapeutic Plasma
Exchange,12September2013.20membersparticipated.
Dr. Sundar Periyavan, Professor, in collaboration with Mr.
Manivannan, National Institute of Biologicals & Indian
Pharmacopoeia Commission, MoHFW, GOI and State Drugs
Control Department, Govt. of Karnataka, conducted a State
CMEprogrammeonHemovigilance, 28 September2013,140
Symposium on ”Mind Science” was organized during the Youth Interfaith
Pilgrimage program of the Foundation for the Universal Responsibility of His
Holiness The Dalai Lama at NIMHANS.
Dr. BK Chandrasekhar Sagar, Additional Professor, Dr.
Gayathri N, Professor, conducted National Workshop on An
Introduction to Electron Microscopy as a Diagnostic Tool,
in collaboration with ILQA, Bangalore, 1 February, 2014. 11
Participants of National Workshop on ICMR ‘Mentor-Mentee’ for Advancement
of Physiological Sciences in India (ICAPS) with the invited speakers and
committee members
Dr.BinduMKutty,Professor,Dr.TNSathyaprabha,Additional
Professor,Dr.BSShankaranarayanaRao,AdditionalProfessor,
conducted National CME on Challenges and Opportunities
in Medical Education, 27 November 2013. 250 members
participated.
Hands-on workshop in Neurochemistry and Electron Microscopy
NEUROPHYSIOLOGY
Dr. Bindu M Kutty, Professor, conducted (i) 5th National
Program Advisory Committee (PAC) meeting in Health
SciencesofSERB,DST,GovernmentofIndia,5-6May2013.
50 members participated (ii) National Symposium on Mind
Science,8August2013.50membersparticipated(iii)National
Workshop on ICMR ‘Mentor-Mentee’ for Advancement of
Physiological Sciences in India [ICAPS], 20-22 September
2013. 60 members participated (iv) 9th National Program
Advisory Committee (PAC) meeting in Health Sciences of
SERB, DST, Government of India, 20-21 March 2014. 55
APPICON 2013: 59th Annual National Conference of Association of Physiologists
and Pharmacologists of India
Dr. TN Sathyaprabha, Additional Professor, Dr. TR Raju,
Sr. Professor & Head, Dr. Bindu M Kutty, Professor, Dr. BS
Shankaranarayana Rao, Additional Professor, Dr. Laxmi T Rao,
Associate Professor, Dr. Phalguni Alladi, Sr. Scientific Officer,
conducted 59th Annual National Conference of Association of
PhysiologistsandPharmacologistsofIndiaonDecadesofResearch
in Physiology and Pharmacology: Reminders to remember and
focus,28-30November2013.1100membersparticipated.
Annual Report
Dr.SathyaPrabhaTN,AdditionalProfessorofNeurophysiology,
Dr.NagarathnaS,AdditionalProfessor,Dr.VeenakumariHB,
Additional Professor, conducted APPICON-2013-Workshop
and Conference, 26-30 November 2013. Approximately 1000
Dr. BS Shankaranarayana Rao, Additional Professor, Dr. T
N Sathyaprabha, Additional Professor, conducted (i) DST
Sponsored National Workshop on Current Physiological
Techniques:FromBasicstoAppliedAspects,26-27November
2013. 380 members participated (ii) National Workshop on
Emerging Trends in Neurophysiology: From Cell to Systems,
26November2013.100membersparticipated(iii)Workshop
on Comprehensive Multiparametric Evaluation of Autonomic
Functions,26November2013.120membersparticipated.
2013-14
NURSING
Dr. Nagarajaiah, Additional Professor, conducted Seminar on
Ethical and Legal Guidelines for Nurses – funded by Dr. RN
MoorthyFoundationFunds,27November2013. 80 members
participated.
Dr. Nagarajaiah, Additional Professor, Dr. Ramachandra,
Principal,NursingCollege,conducted12thNationalConference
ofISPN,8-10February2014.260membersparticipated.
Dr. Sailaxmi Gandhi, Assistant Professor, conducted (i)
Departmental Workshop on Psychiatric Emergencies and
its Management, funded by Dr. RN Moorthy Foundation
Funds, 26 February 2014. 89 members participated (ii)
NationalConferenceonResearchandServiceinPsychosocial
Rehabilitation,8-9March,2014.207membersparticipated.
Dr. Prasanthi Nattala, Dr. Pratima Murthy, conducted
Interdepartmental Focus Group Discussion on Interventions
for Ensuring Community Health and Well-being, including
Substance Use Control – Perspectives of Community
Representatives,29August2013,8membersparticipated.
DST Sponsored National Workshop on Current Physiological Techniques: From
Basics to Applied Aspects
NEUROVIROLOGY
Dr. V Ravi, Professor & Head, Dr. Reeta Mani, Assistant
Professor,Dr.ManjunathaMV,conductedWorkshoponPCR
Technology,20-24January2014.11membersparticipated.
Dr. V Ravi, Professor & Head, Dr. Anita Desai, Additional
Professor, Dr. Reeta Mani, Assistant Professor, conducted
Refresher Training Programme in Dengue and Chikungunya
Serodiagnosis for NVBDCP Sentinel Laboratory Staff of
KarnatakaState,21March2014.40membersparticipated.
Dr. Anita Desai, Additional Professor, conducted two
WorkshopsonEQAS,28June2013and31December2013.10
TechnicalOfficersfrom10StateReferenceLaboratories.
Dr.AnitaDesai,AdditionalProfessor,Dr.VRavi,Professor&
Head, conducted Workshop on Karnataka State Surveillance
Unit, 10 January 2014. 8 Microbiologist from Sentinel site
laboratories.
Mrs. HN Poornima, Lecturer, Mrs. A Shamala, Clinical
Instructor, Mrs. G Jothimani, Clinical Instructor, Mrs. S
Jayamary,ClinicalInstructor,Mr.NRajesh,ClinicalInstructor,
organized Departmental Seminar on Autism and Newer
Perspectives,27June2013.100membersparticipated.
COLLEGE OF NURSING
Dr. Pratibha Swamy, Associate Professor, Ms. Vimal Devi P,
Clinical Instructor, Mrs. P Vijayalakshmi, Clinical Instructor,
Mrs. Suseela T, Clinical Instructor conducted Seminar on
ComplementaryTherapiesinpatientcare,CollegeofNursing,
2September2013.120membersparticipated.
Dr.CRajeswari,Lecturer,Mrs.MythiliD,ClinicalInstructor,
Mrs. N Padmavathi, Clinical Instructor, Mrs. Sathyavathy N,
Clinical Instructor, conducted Seminar on Role of Prosthesis
onHearingImpairment,CollegeofNursing,26April2013.60
Mrs. Poornima HN, Lecturer, Mrs. Shamala A, Clinical
Instructor, Mrs. S Jeyamari, Clinical Instructor, Mrs. G
Jothimani,ClinicalInstructor,Mr.RajeshN,ClinicalInstructor
conductedSeminaronAutismandNewerPerspectives,College
ofNursing,27June2013.120membersparticipated.
Annual Report
2013-14
Dr. S Valliammal, Lecturer, Mrs. Kanitha D, Lecturer, Mrs.
Poornima HN, Lecturer, conducted Workshop on Immediate
Newborn Care, College of Nursing, 26-27 July 2013. 120
Dr. Pratima Murthy, Professor, Dr. VNR Pandian, Additional
Professor of Psychiatric Social Work, conducted Workshop
forCBOsofWomeninSexWork,14March2014.35members
participated.
Mrs. Kanitha D, Lecturer, Dr. S Valliammal, Mrs. Deiva
K, Clinical Instructor, Mrs. Sivakami S, Clinical Instructor
conducted Seminar on Breast Crawl, College of Nursing, 18
January2014.120membersparticipated.
Dr. BN Gangadhar, Professor, Dr. Jagadisha Thirthalli,
Additional Professor, Dr. Muralidharan Kesavan, Associate
Professor,Dr.ShivaramaVarambally,AssociateProfessor,Dr.
C Naveen Kumar, Assistant Professor, Dr. A Shyam Sundar,
Assistant Professor, Dr. Preeti Sinha, Assistant Professor,
Dr. Biju Viswanath, Assistant Professor, Dr. Shashidhara
HN, Senior Resident (1 year PDF), Dr. Rajendra KM, Senior
Resident, Dr.Vijay Danivas, MD with Post DPM, conducted
ECT Symposium 2013, NIMHANS, 7 December 2013. 228
PSYCHIATRY
Dr. Santosh K Chaturvedi, Professor, Dr. Pratima Murthy,
Professor, Dr. Arun Kandasamy, Assistant Professor,
conducted workshop on (i) Professional Skills Enhancement
Programme, 8 January 2014. 25 members participated (ii)
EarlyCareerMentalHealthProfessionals,9-11January2014.
17membersparticipated.
Dr. Santosh K Chaturvedi, Professor, Dr. Geetha Desai,
Associate Professor, conducted interdepartmental Workshop
on (i) Chronic Pain - (a) 15 December 2013. 25 members
participated(b)23March2014.40membersparticipated.
Dr.SrikalaBharath,Professor,conductedNationalWorkshop
on (i) Empowering Adolescents Using Life Skills EducationTraining of Life Skills Educators, 26-28 September 2013. 28
membersparticipated(ii)EmpoweringAdolescentsusingLife
SkillsEducation-TrainingofLifeSkillsEducators,13-15March
Dr. Srikala Bharath, Professor, Dr. Preeti Sinha, Assistant
Professor, conducted Workshop on Positive Aging (Part of
Elderly Fortnight Activities), NCWB, NIMHANS, 1 October
2013.30-35membersparticipated.
Dr. Prabha S Chandra, Professor, Dr. Senthil Kumar Reddi,
Assistant Professor, Dr. Krishna Prasad, Senior Resident,
conducted Training in Emergency Psychiatry for NIMHANS
Casualty Medical Officers, NIMHANS, 10 April 2013. 9
Dr. Pratima Murthy, Professor, conducted Workshop on
AddressingRiskFactorsforNon-CommunicableDiseases,6-7
February2014.25membersparticipated.
Dr.PratimaMurthy,Professor,Dr.SureshBadamath,Additional
Professor,Dr.NaveenKumarC,AssistantProfessor,conducted
Workshop on Forensic Psychiatry training, NIMRPSYCON, 7
March2014.25membersparticipated.
Release of ECT Administration Manual (2nd Edition) at the ECT Symposium 2013
Dr. G Venkatasubramanian, Additional Professor, Dr.
BN Gangadhar, Professor, conducted CME on Psychiatric
Classification, NIMHANS, 20 February 2014. 200 members
participated.
Dr. G Venkatasubramanian, Additional Professor, Dr.
Shivarama Varambally, Associate Professor, conducted
CME on The Art & Science of Choosing Antipsychotics in
Schizophrenia. Individualized Schizophrenia Treatment and
Reintegration (InSTAR), NIMHANS, 14 March 2014. 130
Dr.PTSivakumar,AdditionalProfessor,conductedWorkshop
onYogaforelderly,3October2013.30membersparticipated.
Dr. Arun Kandasamy, Assistant Professor, conducted (i)
Departmental workshop on Tobacco Related Problem and its
Intervention,24-25September2013.20membersparticipated
(ii) One-month Orientation Programme on Substance Use
Disorders, 15 November-13 December 2013. 50 members
participated.
Annual Report
PSYCHIATRIC REHABILITATION
Dr. Jagadisha Thirthalli, Additional Professor, Dr. Geetha
Desai, Associate Professor, Dr. Sivakumar T, Assistant
Professor, Dr. Avinash Waghmare, Senior Resident, Dr.
Poornima Bhola, Associate Professor of Clinical Psychology,
Dr. Nirmala BP, Associate Professor of Psychiatric Social
Work, Dr. Sailaxmi Gandhi, Assistant Professor of Nursing,
conducted Interdepartmental Volunteer Training Program,
National Conference on Research and Services in Psychiatric
Rehabilitation:FocusonRecovery,9July2013.22volunteers
participated.
National Conference on Research and Services in Psychiatric Rehabilitation:
Focus on Recovery
Dr.NaveenKumarC,AssistantProfessor,Dr.SKChaturvedi,
Professor, Dr. Jagadisha Thirthalli, Additional Professor, Dr.
GeethaDesai,AssociateProfessor,Dr.SivakumarT,Assistant
Professor, Dr. Avinash Waghmare, Senior Resident, Dr.
Poornima Bhola, Associate Professor of Clinical Psychology,
Dr.DevvrataKumar,AssociateProfessorofClinicalPsychology,
Dr.HesiHerbert,JuniorConsultantofClinicalPsychology,Dr,
NirmalaBP,ofPsychiatricSocialWork,Dr.SailaxmiGandhi,of
Nursing,conductedInterdepartmentalNationalConferenceon
ResearchandServicesinPsychiatricRehabilitation:Focuson
Recovery,8-9March2014.207membersparticipated.
Interdepartmental National Conference on Research and Services in Psychiatric
Rehabilitation: Focus on Recovery
Dr. Nirmala BP, Associate Professor of PSW, Udgiri S, PhD
Scholar,Dr.WaghmareA,SeniorResident,Dr.SivakumarT,
2013-14
Assistant Professor, Dr. Kumar CN, Assistant Professor, Dr.
Sailaxmi Gandhi, Assistant Professor of Nursing, Dr. Bhola
P, Associate Professor of Clinical Psychology, Dr. Desai G,
Associate Professor, Dr. Thirthalli J, Additional Professor,
Dr. Chaturvedi SK, Professor, conducted one month National
Orientation Programme in Psychiatric Rehabilitation, August
toSeptember2013.4membersparticipated.
Participants of one-month National Orientation Programme In Psychiatric
Rehabilitation with the organisers
Dr. Sivakumar T, Assistant Professor, Dr. Jagadisha T,
AdditionalProfessor,Dr.GeethaDesai,AssociateProfessor,Dr.
PoornimaBhola,AssociateProfessorofClinicalPsychology,Dr.
Devvarta Kumar, Associate Professor of Clinical Psychology,
Dr. Nirmala BP, Associate Professor of PSW, Dr. Sailaxmi
Gandhi, Assistant Professor of Nursing, Dr. CN Kumar,
Assistant Professor, Dr. A Waghmare, Senior Resident, Ms. S
Udgiri,Ph.DScholar,Dr.HesiHerbert,JuniorConsultantof
ClinicalPsychology,Dr.ChethanB,NonPGJuniorResident
ofPsychiatry,conductednineinterdepartmentalWorkshopson
Caregivers’EducationandSupportProgramme,fundedbyDr.
Ramachandra N Moorthy Foundation for Mental Health and
NeurologicalSciences-topicon(a)LivingwithSchizophrenia,
16 July 2013. 17 Caregivers and 20 Professionals participated
(b) Marital issues in people with Schizophrenia, 20 August
2013. 23 Caregivers and 21 Professionals participated (c)
Community reintegration, 17 September 2013.30 Caregivers
and 20 Professionals participated (d) Portrayal of Persons
withSchizophreniainMedia:MythsandRealities,15October
2013. 25 Caregivers and 25 Professionals participated (e)
Coping with burnout, 19 November 2013. 24 Caregivers and
19Professionalsparticipated(f)Whatafterme?17December
2013. 25 Caregivers and 28 Professionals participated (g)
Promoting therapeutic family environment, 21 January 2014.
32 Caregivers and 20 Professionals participated (h) Welfare
benefits for persons with psychiatric disorders, 18 February
Annual Report
2013-14
2014.27caregiversand20professionalsparticipated(i)NGO’s
workingformentallyillpatients,18March2014.18caregivers
and 20 professionals participated. (Total: 221 caregivers and
188professionalsparticipated).
Dr. K Sekar, Professor & Head, Mr. Susindar Babu, Deputy
Director, CBHI, DRHS, MoH and FW, GoI, Kendriya Sadan,
Bangalore, conducted Interdepartmental Workshop on
AwarenessofICF,DisabilityandHealth,11October2013.60
Dr. K Sekar, Professor & Head, conducted Interdepartmental
Workshop on Psychosocial Support for Children for
ChhattisgarhRefugeesinAPforASDS,SIRINGOs,Khammam
District, Andhra Pradesh, 19 October 2013. 15 members
participated.
Dr.NKrishnaReddy,AdditionalProfessor,Dr.Thirumoorthy,
Additional Professor, Dr. N Janardhana, Assistant Professor,
conducted Departmental Workshop for lay counsellors on
Common Neurosurgical Illness seen in Casualty, November
Dr. R Dhanasekara Pandian, Additional Professor, conducted
Two months Interdepartmental Training Programme on
Addiction Counselling for NRHM Social Workers from
Himachal Pradesh, November and December-2013. 12
Dr.AThirumoorthy,AdditionalProfessor,Dr.NJanardhana,
Assistant Professor, organized (i) 2 days National workshop
on Mental Health Care Services for TNPVP Chennai, 29-30
April2013.30membersparticipated(ii)NationalOrientation
Training Program for Amateur Counselor Forum Samadana
CounselingCentre,Bangalore,(LifeSkillEducation),10August
Dr.AThirumoorthy,AdditionalProfessor,organizedaNational
Orientation Training Program for Amateur Counselor Forum
SamadhanaCounselingCentreBangalore(SuicidePrevention),
12thFebruary2014.26membersparticipated.
Dr. Md. Ameer Hamza, Associate Professor, conducted (i)
National Workshop on Adolescent Sexuality, Reproductive
Health and Gender Equality- (a) 2-4 May 2013. 19 members
participated(b)11-13September2013.35membersparticipated
(ii) ICMR Workshop on Adolescent Sexuality, Reproductive
Health and Gender Equality- (a) 16-18 September 2013. 32
membersparticipated(b)19-21September2013.36members
participated(c)24December2013.16membersparticipated.
Dr. BP Nirmala, Associate Professor, Dr. N Janardhana,
Assistant Professor, conducted Departmental Workshop on
(i) Counseling Techniques in Rehabilitation for the students
ofRehabilitationScience,St.Anne’scollegeBangalore,28-30
November 2013. 26 members participated (ii) Mental Illness
and Community Based Rehabilitation, 15-16 April 2013. 15
Dr. N Janardhana, Assistant Professor, Professor, Dr. R
Parthsarathy, Dr. D Muralidhar, Professor, Dr. K Sekar,
Professor & Head, Dr. Shekar Seshadri, Professor of Child
and Adolescent Psychiatry, conducted Interdepartmental
Workshop on (i) Counseling and Capacity Building for the
HouseParentsofGovernmentChildrenHomes,ICPS-(a)16-17
April 2014. 41 members participated (b) 18-19 April 2013. 42
members participated. (ii) Counseling and Capacity Building
fortheLegalCumProbationOfficersofGovernmentChildren
Homes, ICPS, 8-12 July 2013. 21 members participated (iii)
Counseling and Capacity Building for the Institutional Heads
ofGovernmentChildrenHomes,ICPS,7-9October2013.29
members participated (iv) Counseling and Capacity Building
for the Probation Officers Grade II of Government Children
Homes,ICPS,9-11December2013.30membersparticipated.
Dr. N Janardhana, Assistant Professor, Dr. A Thirumoorthy,
AdditionalProfessor,conductedDepartmentalTraining(i)For
theCounselorsfortheAmateurCounselorFormonCommon
Neurological Problems, 13 September 2013. 40 members
participated(ii)FortheCounselorsfortheAmateurCounselor
Form on Child Mental Health Problems, 10 April 2013. 80
membersparticipated(iii)FortheCounselorsfortheAmateur
CounselorFormonCommonNeurologicalProblems.13June
Dr.NJanardhana,AssistantProfessor,conductedDepartmental
TrainingontheCounselingChildreninDifficultCircumstances
for the Integrated Child Protection Personnel of Orissa, 18
January2014.18membersparticipated.
Dr.SatishCGirimaji,Professor&HeadofChildandAdolescent
Psychiatry, Dr. N Janardhana, Assistant Professor, Dr. H
Uma Hirasave, Professor of Clinical Psychology, conducted
Interdepartmental WorkshoponSexuality amongIntellectual
Disabled Children and Young Adults, 21 December 2013. 150
2013-14
Annual Report
Dr.VrandaMN,AssistantProfessorandDr.KSekar,Professor
&Head,conductedDepartmentalWorkshoponRecentTrends
inPsychiatricSocialWork,26-27September2013.40members
participated.
Dr. K Sekar, Professor & Head, Dr. E Aravind Raj, Assistant
Professor, conducted National Departmental Consultative
MeetingonReviewofPsychoSocialSupportandMentalHealth
Services(PSSMHS)inDisasterManagement,8January2014.
Dr.KavitaVJangam,AssistantProfessor,Dr.KSekar,Professor
&Head,conductedDepartmentalWorkshopon(i)Psychosocial
PreparednessinDisasterManagement,May2013.15members
participated(ii)RecentTrendsinPsychiatricSocialWork,1820September2013.25membersparticipated(iii)TheRecent
Trends in Clinical Practices in Mental Health, June 2013. 17
Dr.KSekar,Professor&Head,Ms.KavithaP,Ph.D.Scholar,
conducted Departmental Workshop on Psychosocial Care
for Children in Difficult Circumstances, 20-29 June 2013. 6
Dr.KSekar,Professor&Head,Dr.SanjeevKumarManikappa,
Ph. D. Scholar, Ms. Revathi S, PSSDM student, conducted
Departmental Workshop on Training of trainers psychosocial
care and support for IDPs with special reference to children,
19-24August2013.6membersparticipated.
Dr.KSekar,Professor&Head,Ms.RevathiS,PSSDMstudent,
Ms. Paramita B, PSSDM student, conducted Departmental
Workshop on Training of Trainers Psychosocial Care for
DisasterRefresherCourse,23September2013-5October2013.
Dr. Shivashankar, Professor & Head of Speech Pathology and
Audiology,Dr.JamunaRajeshwaran,AdditionalProfessor,Dr.Rose
Dawn, Associate Professor of NIIR, organized Interdepartmental
MeetingoftheMinds,conductedbyHongKongUniversity(Prof.
HoShuLeong,ProfLeeTatiaandProfTanLeeHai,Universityof
HonKong),17August2013.150membersparticipated.
WorkshoponEarlyIntervention&IssuesofViolence&Sexual
Harassment of People with Disabilities, 23 November 2013.
II.
Scientific Programs
NIMHANS
A.
International
Organized
Outside
Dr. BS Shankaranarayana Rao, Additional Professor of
Neurophysiology,InternationalworkshoponHighereducation
and career opportunities in Biotechnology. 1st International
and 3rd National Conference of Biotechnology, Bioinformatics
and Bioengineering. Tirupati, India, 28-29 June 2013. 140
Dr.LaxmiTRao,AssociateProfessorofNeurophysiology,conducted
Symposium on Environment, Nutrition and Brain Functions.
InternationalSymposiumonEmergingTrendsandChallengesin
Neuroscience and 31st Annual Conference of Indian Academy of
NeurosciencesandlocalChapterofIAN,Allahabad,UttarPradesh,
India,25-27October2013.150membersparticipated.
Dr. V Ravi, Professor & Head of Neurovirology and Dr.
Narayan Rishi, conducted International Asia pacific Congress
of Virology, Amity University, 16-20 December 2013. 350
Dr. Pratima Murthy, Professor of Psychiatry, Dr Girish N,
Additional Professor of Epidemiology, Dr Manoj, Associate
Professor of Clinical Psychology conducted (i) Symposium on
TobaccoControl,7thCongressoftheAsianSocietyforChildand
AdolescentPsychiatryandAlliedProfessionsand12thBiennial
Conference, Indian Association for Child and Adolescent
MentalHealth,27September2013.75membersparticipated.
Dr.ShekharSeshadri,Professor,conductedNationalWorkshop
onPracticalManagementofChildSexualAbuseintheIndian
Setting.7thCongressofAsianSocietyforChildandAdolescent
Psychiatry&AlliedProfessions(ASCAPAP),25-28September
B.
National
BIOSTATISTICS
Dr.NShivashankar,Professor&Head,Dr.SatishCGirimaji,
Professor & Head, Child and Adolescent Psychiatry, Sevain-Action, an NGO as well as a State Nodal Agency Centre
for National Trust, conducted Interdepartmental State level
Dr. K Thennarasu, Professor, conducted Workshop on
Biostatistics and Research Methodology, CIP, Ranchi, 5-8
Annual Report
2013-14
Dr. K Thennarasu, Professor, Dr. P Marimuthu, Additional
Professor, Dr. Marimamma Philip, Sr. Scientific Officer, Mr.
ShivajiRao,ComputerProgrammer,conductedWorkshopon
Biostatistics and Research Methods in Aerospace Medicine,
Institute of Aerospace Medicine, Bangalore, 19-21 September
Dr. Marimamma Philip, Sr. Scientific Officer, conducted
workshopon(i)StatisticalMethodsinPsychology,Department
of Psychology, Jain University, Bangalore, 28 February 2014.
20 members participated (ii) Biostatistics and Research
Methodology workshop, LGBR IMH, Tezpur, 7-8 February
CHILD AND ADOLESCENT PSYCHIATRY
Dr. Satish C Girimaji, Professor & Head, conducted Regional
WorkshoponChildPsychotherapyinCMEonPsychotherapy,
DepartmentofPsychiatry,KMC,Manipal,16November2013.
Dr.ShobaSrinathandDr.AnilTambi,conductedStateCMEon
ChildandAdolescentPsychiatry,SMSMedicalCollege,Jaipur,
10-11March2014.50membersparticipated.
CLINICAL PSYCHOLOGY
Dr.AhalyaRaguram,Professor,conductedRegionalworkshop
on Psychiatry Update-2013, KMC, Manipal, 16-17 November
Dr. Uma H, Professor, conducted (i) Workshop on Child
PsychologyandChildMentalHealthforPoornaPramatiSchool
Teachers,12June2013.8membersparticipated(ii)Sessionon
StressManagementforJudgesatKarnatakaJudicialAcademy,
Bangalore, 11 September 2013. 15 members participated (iii)
ASessiononProblemsonOldAge,HKSangha,9November
2013.50membersparticipated(iv)WorkshoponSexEducation
forChildrenandAdolescentswithMentalRetardation,Fame,
India,4January2014.20membersparticipated.
Dr. Mahendra P Sharma, Professor, conducted (i) Regional
Workshop on Cognitive Behavior Therapy: Principles and
Applications,InstituteofBehavioralSciences,GujaratForensic
Sciences University, Gandhinagar, 23 August 2013. 30
membersparticipated(ii)WorkshoponMindfulnessIntegrated
Cognitive Behavioral Interventions in Emotional Disorders,
DepartmentofPsychiatry,KasturbaMedicalCollege,Manipal,
16-17November2013.80membersparticipated.
Dr.PaulomiMSudhir,AdditionalProfessorandDr.Roopesh
BN, Assistant Professor, conducted School Mental Health
ProgramforTeachersofPSBB,LLA,Bangalore,18March2013.
Dr.PaulomiM.Sudhir,AdditionalProfessor,conductedSession
on Mental Health Program for Executives and Managers of
AshokLeylandLimited,Hosur,28December2013.45members
participated.
Dr.KeshavKumar,AdditionalProfessor,conducted(i)National
Symposium on Cognitive retraining in Schizophrenia, 40th
NationalConferenceofIndianAssociationofClinicalPsychologist
(NACIACP), Kattankulathur, Chennai, 27 February-1 March
2014.70membersparticipated(ii) PreconferenceWorkshopon
NeuropsychologicalRehabilitationinHeadInjury,40thNational
conference of Indian Association of Clinical Psychologist
(NACIACP), Kattankulathur, Chennai, 27 February 2014. 30
members participated (iii) Workshop on Emerging Trends
in Neuropsychological Rehabilitation, National Seminar on
NeuropsychologicalRehabilitation,EthirajCollegeforWomen,
Chennai, 18 December 2013. 18 December 2013. 75 members
participated (iv) Workshop on Cognitive Rehabilitation,
SOAHS, Manipal University, Manipal, 14-15 December 2013.
75membersparticipated(v)Workshopon Psycho-somaticand
Memory Management. Professional Certificate Programme
on Tea Tasting and Marketing (PCP-TTM). Indian Institute of
PlantationManagement,GovernmentofIndia,16May2013.
Dr. M Manjula, Associate Professor, conducted (i) Workshop
on Handling Exam Stress Effectively, Indian Institute of
Technology,Hyderabad,3April2013.35membersparticipated
(ii)WorkshoponHowtoFaceExamsEffectively,JainUniversity,
Bangalore,6April2013.50membersparticipated(iii)Meeting
theChallenge:AworkshoponHandlingAcademicsEffectively,
ChristPre-UniversityResidentialCollege,11-12June2013.100
membersparticipated(iv)MaintainingHealthyRelationships:
A workshop for the Youth, Indian Institute of Science,
Bangalore,19September2013.18membersparticipated.
Dr. Devvarta Kumar, Associate Professor, conducted Workshop
on Metacognitive Therapy for Delusions, Department of Clinical
Psychology, Sri Ramchandra University, Chennai, 14 August
2013 (ii) ICSSR sponsored Workshop on Rating Scales, Bharati
VidyapeethDeemedUniversity,YCISSR,Pune,14December2013.
Annual Report
Dr. Poornima Bhola, Associate Professor, conducted Session
on (i) Managing Stress Levels in the IT Industry, NTT Data,
Bangalore, 16 January, 2014. 90 members participated (ii)
Mental Health Awareness and Help Seeking, Jain University,
Bangalore,3February2014.70membersparticipated.
Dr.RoopeshBN,AssistantProfessorandDr.VeenaAS,Assistant
Professor, conducted Workshop on (i) Gender Sensitivity for
Primary School Students, Bangalore, 28 November 2013. 60
members participated (ii) Gender Sensitivity for High School
students,Bangalore,29November2013.40membersparticipated.
Dr. Roopesh BN, Assistant Professor, conducted (i)
Neuropsychological Tests used with Children, Manipal,
Udupi District, 8 January 2014. 25 members participated (ii)
Workshop on Development of Cognitive Functions, Dept. of
ClinicalPsychology,Manipal,UdupiDistrict,7January2014.
Dr. Roopesh BN, Assistant Professor and Ankur Foundation,
conductedWorkshoponManagementofBehaviorProblemsin
ChildrenwhoareinFosterCare,Bangalore,8January2014.40
EPIDEMIOLOGY
2013-14
NEUROANAESTHESIA
Dr. KR Madhusudan Reddy, Professor & Head, Dr.
Bhadrinarayan, Professor, conducted Malathi Memorial
Oration.ISNACC2014NationalConference,Jaipur,31January
Dr. Sriganesh K, Associate Professor, Dr. Sudhir V, Assistant
Professor, conducted CME on Transfusion Medicine for
Anaesthesiologists:WhatWeNeedtoKnow,12January2014.
NEUROCHEMISTRY
Dr. Utpal Tatu, IISc, Bangalore, Dr. Srinivas Bharath MM,
Additional Professor, conducted 5th Annual meeting of the
Proteomics Society of India, 28-30 November 2013. 400
NIIR
Dr. Rose Dawn Bharath, Associate Professor, conducted
FunctionalMRI:HandsonWorkshop,PGI,Chandigarh,12-21
August2013.15membersparticipated.
NEUROLOGICAL REHABILITATION
Dr.GururajG,Professor&HeadandDr.NGirish,Additional
Professor,conducted(i)StrengtheningDistrictMentalHealth
Programme with Public Health Approaches and Strategies,
Tamil Nadu, 17-19 June 2013. 35 members participated (ii)
StrengtheningDistrictMentalHealthProgrammewithPublic
Health Approaches and Strategies in Kerala, Cochin, Kerala,
6-8December2013.35membersparticipated.
Dr. Gautham MS, Assistant Professor and Dr. Girish N,
AdditionalProfessor,conducted StressManagementWorkshop
for Mid-Level Managers of Toyota-Kirloskar Motor Pvt.
Limited,Bidadi,5October2013.60membersparticipated.
Dr.NGirish,AdditionalProfessor,conducted(i)Preconference
CMEon-(a)RecognizingHarmfromAlcoholUse(b)Integrating
ScreeningforGeriatricMentalHealth,KACHSilvercon2014,
BangaloreMedicalCollegeandResearchInstitute,Bangalore,
30 November 2013. 32 members participated (ii) Workshop
on Commemorating founding day of CPH at NIMHANS, Sri
DevarajUrsUniversity,Tamaka,Kolar,13December2013.100
Dr. Anupam Gupta, Additional Professor, conducted (i)
IAPMR National Mid-Term CME and Pre Conference
Workshop on Botulinum Toxin- An In Spasticity
Management,Mumbai,India,20-22September2013.More
than60membersparticipated(ii)2ndNationalConferenceof
IFNR-Indian Federation of Neuro-Rehabilitation, Mumbai,
Maharashtra, 27 February-1March 2014. More than 100
Dr. Pradnya Dhargave, Sr. Physiotherapist organized a
Workshop on Empowering Women on Physical, Mental,
Spiritual and Intellectual Health on International Women’s
Day,withSamyakPrabodhanPratisthan,8March2014.
Mr. T Karthikeyan, conducted Workshop and invited
as a resource person on Physiotherapist Prospective
on Traumatic Brain Injury, Dr. MV Shetty College of
Physiotherapy,Mangalore,onWorldPhysiotherapyDay,8
September2013.
Annual Report
2013-14
NEUROLOGY
Dr. PS Mathuranath, Additional Professor, Dr. Ratnavalli,
Manipal Hospital, conducted 3rd WFN Teaching Course in
Cognitive Neurology, Manipal Hospital, Bangalore, 5-7 April
NEUROPHYSIOLOGY
Dr.BSShankaranarayanaRao,AdditionalProfessor,conducted
National Workshop on Research Challenges in EEG Signal
AnalysisandApplication,jointlywithDr.AmbedkarInstitute
of Technology, Bangalore, 25-26 June 2013. 80 members
participated.
Dr. BS Shankaranarayana Rao, Additional Professor, Dr.
TN Sathyaprabha, Additional Professor and Dr. Sandya T
Avadhany, St. John’s Medical College, conducted National
WorkshoponTechniquesinBody CompositionMeasurements
inHealthandDisease,St.John’sMedicalCollege,Bangalore,
26November2013.60membersparticipated.
Dr. BS Shankaranarayana Rao, Additional Professor, Dr. TN
Sathyaprabha,AdditionalProfessor,Gp.Capt.(Dr)DKDubey,
conducted National Workshop on Evaluation of Aerospace
StressesUsingSimulators,IAM,Bangalore,27November2013.
Dr. TN Sathyaprabha, Additional Professor, conducted
Workshop on Research Methodology, Institute of Unani
Medicine,Bangalore,October2013.250membersparticipated.
Dr. Bindu M Kutty, Professor of Neurophysiology, conducted
National CME on Basics of Sleep and Sleep Disorders, Raja
Rajeswari Medical College, Bangalore, 9 March 2014. 200
PSYCHIATRY
Dr. Arun Kandasamy, Assistant Professor, conducted
DepartmentalWorkshoponOverviewofSubstanceAbuseand
IllEffectsofTobaccofortheTVSemployees,HosurCampus,28
May2013.100membersparticipated.
Dr.NaveenKumarC,AssistantProfessorandDr.VishalIndla,
Chief Psychiatrist of Vijayawada Institute of Mental Health
and Neurosciences, conducted National Debate for Young
Psychiatrists:PsychiatristshavenoRoletoPlayinSocialIssues.
FortheMotion:Dr.RishikeshBehereandDr.K.ChandraSekhar,
Againstthemotion:Dr.RukshedaSyedaandDr.HarishShetty.
Vijayawada Institute of Mental Health and Neurosciences,
Vijayawada,17January2014.50membersparticipated.
Dr. SK Chaturvedi, Professor and Faculty of Pain Palliative
Care department, St John’s Hospital, conducted Workshop on
Communication skills, Pain and Palliative Care Unit, St John’s
Hospital,Bangalore,15November2013.20membersparticipated.
Dr. SK Chaturvedi, Professor, Dr. Sushma Bhatnagar,
Professor of Psychiatry, AIIMS, conducted workshop on (i)
Communication Skills, AIIMS, New Delhi (a) 29 June 2013.
35membersparticipated(b)15December2013.40members
participated(ii)1stIndianCancerCongress2013,21November
Dr.SKChaturvedi,Professor,Dr.JayitaDeodhar,Psychiatrist,
Dr. Prabha S Chandra, Professor, conducted Workshop
on International Psycho Oncology Society Academy, Tata
MemorialHospital,Mumbai,29November-1December2013.
Dr. Santosh Loganathan, Associate Professor, conducted a
symposium during -ANCIPS, 2014 Intervening with Stigma
andDiscriminationinDifferentSettings,18January2014.3040membersparticipated.
Dr.VivekBenegal,ProfessorconductedWorkshoponMotivation
Enhancement,GoaPsychiatricSociety,Panjim,April,2013.24
membersparticipated(ii)NationalLevelWorkshoponBurden
of Alcohol use in India. Alcohol Taxation And Multi-Sectoral
Policy Interventions to Counter The Harms Associated With
Alcohol Consumption, Public Health Foundation, New Delhi,
April,2013.80membersparticipated.
Dr. Prabha S Chandra, Professor, Dr. Muralidharan K,
Associate Professor, conducted (i) NIMRCPSYCON 2014, 2nd
JointConferenceofNIMHANS,BangaloreandRoyalCollegeof
Psychiatrists,UK,7-8March2014.200membersparticipated
(ii) National Workshop on OCD- Non Responsive to SSRI -
WhatNext,AnnualNationalConferenceofIndianAssociation
ofPrivatePsychiatry(ANCIAPP),NIMHANS,7-8March2014.
Dr. K Sekar, Professor & Head, Dr. Sanjeeva Kumar, Ph. D.
Scholar, conducted Workshop on PSC in DMToT on Disaster
Management. Administrative, Training Institute, Mysore, 26
Annual Report
Dr. K Sekar, Professor & Head, Kavitha P, Ph. D. Scholar,
Mahesha R, Field Coordinator, conducted Workshop on (i)
Psychosocial Care for Children in Difficult Circumstances,
PRERANA,Raichur,10-11June2013.43membersparticipated
(ii) Psychosocial care for children in difficult circumstances,
Sri Gowthama Grama Kalyana Kendra, 13-14 June 2013. 42
Dr. K Sekar, Professor & Head, Sudeep Jacob Joseph, PhD
Scholar, conducted (i) Sensitization Program on Student
EnrichmentandEnrichingFamilyLifeforChildrenwithVisual
Disability, SAMA, Bangalore, 10 April 2013. 10 members
participated (ii) Student Enrichment Program for Children
withVisualDisabilities,SAMA,Bangalore,20-25May2013.12
membersparticipated(iii)EnrichingFamilyLifeforChildren
with Visual Disabilities, SAMA, Bangalore 20-25 May 2013.
14membersparticipated(iv)WorkshoponICFSensitization,
CBHI,11October2013.12membersparticipated.
Dr.KSekar,Professor&Head,conducted(i)CBHITrainingOrientation course on Family of International Classification
(ICD-10 & ICF), Bangalore, 9 January 2014. 20 members
participated(ii)WorkshoponEffectualDisasterManagement
in Karnataka Special Reference to Malnad Areas, Kuvempu
University, Sankarghatta, 6-7 March 2014. 60 members
participated.
Dr. K Sekar, Professor & Head, Dr. E Aravind Raj, Assistant
Professor, Dr. Kavita V Jangam, Assistant Professor, Ms.
Revathi S, PSSDM student, Ms. Paramita B, PSSDM student,
conducted 2 days Sensitization Program on Psychosocial
Preparedness Disaster Management, Christ University,
Bangalore,5-6March2014.31membersparticipated.
Dr.KSekar,Professor&Head,Dr.SanjeevKumarManikappa,
PhD Scholar, Ms. Paramita B, PSSDM student, Workshop
on Training of Trainers on Psychosocial Support Recover
SupporttoCommunitiesAffectedbyEthnicConflictinAssam
and Mizoram-Tripura States of North-East India, North East
Diosecean Social Forum, Joypur, Kharguli, Guwahati, 27-31
May2013.11membersparticipated.
Dr.KSekar,Professor&Head,Ms.ParamitaB,PSSDMstudent,
conducted(i)3-dayEssentialModuleTrainingonPsychosocial
SupportPostUttarakhandDisasterforFHVinGuptakashi,ITI
Guptakashi,Rudraprayag,Uttarakhand,17-19August2013.36
membersparticipated(ii)OnedaySensitizationandOrientation
Workshop for Roshni Nilaya School of Social Work Students
onPSSforDisasterAffectedSurvivorsinUttarakhand,Roshni
2013-14
Nilaya School of Social Work, Mangalore, 9 October 2013. 17
Dr.KSekar,Professor&Head,Mr.SudeepJacobJoseph,PhD
Scholar,Ms.ParamitaB,PSSDMstudent,conductedTraining
onTrainersonPsychosocialFirstAidInAirDisastersforInter
GlobeAviationLtd.,IndigoOffice,Indigo,Gurgaon,Haryana,
23-28September2013.20membersparticipated.
Dr.KSekar,Professor&Head,Dr.VikramSinghRawat,Ms.
Paramita B, PSSDM student, conducted Training of Medical
officers in Disaster Mental Health and Psychosocial Support
Post Uttarakhand Disaster, Regional Health and Family
Welfare Training Centre, Dehradun, 21-26 October 2013. 36
Dr. K Sekar, Professor & Head, Mr. Susinder Babu, Deputy
Director, CBHI, DRHS, MoH and FW, GoI, Kendriya Sadan,
Bangalore,conductedWorkshoponInternationalClassification
ofFunctioning,Disability,Health:ImportanceandUses,Rajiv
GandhiGeneralHospital,StanleyMedicalCollege,Chennai,17
Dr. N Krishna Reddy, Additional Professor, Dr. BP Nirmala,
Associate Professor, conducted Workshop on Sensitization
programs for the Caregivers of Persons with Cerebral Palsy,
Hubli,22-23June2013.150membersparticipated.
Dr. Prakashi Rajaram, Additional Professor, conducted
Workshopon(i)RoleofParentsinfacilitatingLifeSkillsamong
Adolescent Students I, Mothers’ Touch School, Jayanagar,
Bangalore, 6 July 2013. 20 members participated (ii) Role of
Parents in Facilitating Life Skills among Adolescent Students
II, Mothers’ Touch School, Jayanagar, Bangalore, 8 July
2013. 50 members participated (iii) Skill Training in Clinical
Social Work Practice, School of Social Work, Roshni Nilaya,
Mangalore, 27 February 2014. 18 members participated (iv)
Enhancing Professional Social work Skills for the Future,
SchoolofSocialWork,RoshniNilaya,Mangalore,28February
Dr. A Thirumoorthy, Additional Professor, conducted
WorkshoponWomenEnterprisingSkillsTrainingforUG/PG
SC/STGirlsStudents(StressManagementprogram),National
InstituteofTechnology,Karnataka,Surathkal,Mangalore,1718August2013.50membersparticipated.
Dr. Nirmala, Associate Professor, conducted Workshop on
Building a Team for organizing Guidance and Counselling
Annual Report
2013-14
PSYCHOPHARMACOLOGY
ProgrammeinSchool,SchoolCounsellorsofBhutan,NIPPCD,
Bangalore,25June2013.12membersparticipated.
Dr. N Janardhana, Assistant Professor, conducted Workshop
on (i) Psychosocial Management for Children with Mental
HealthProblems,SDMCollege,Ujjre,25September2013.90
members participated (ii) CBR and Mental Illness, Mobility
India,20March2014.65membersparticipated(iii)Inclusion
ofMentalHealthinDevelopmentwork,IGSSS,Delhi,10June
Dr. N Janardhana, Assistant Professor and Manjula B,
Psychiatric Social Worker, conducted Workshop on (i)
Addressing Needs of Care Givers of PWMI and Stress
Management,APD,8January2014.40membersparticipated
(ii)CounsellingSkillsforCounsellorsworkingwithRelationship
IssuesamongFemaleSexWorkers,KHPT,Bagalkote,17June
Dr. Vranda MN, Assistant Professor, conducted Workshop on
(i)PromotionofMentalHealthandPsychologicalWell-beingof
AdolescentsinSchools,ByreshwaraVidyasansthe,Srinivasapura,
27-28January2014.40membersparticipated(ii)Promotionof
Mental Health and Psychological Well-being of Adolescents in
Schools,St.TeresaGirl’sHighSchool,KGF,29-30January2014.
42membersparticipated(iii)PromotionofMentalHealthand
Psychological Well-being of Adolescents in Schools, Women’s
College, Kolar, 31 January-1 February 2014. 43 members
participated(iv)PromotionofMentalHealthandPsychological
Well-beingofAdolescentsinSchools,KLEEducationalInstitute,
Maluru, 17-18 February 2014. 56 members participated (v)
Promotion of Mental Health and Psychological Well-being of
AdolescentsinSchools,SSSharadaGirl’sHighSchool,Mulbagal,
19-20February2014.57membersparticipated(vi)Promotionof
Mental Health and Psychological Well-being of Adolescents in
Schools, Women’s Pre-University College, Bangarapete, 21-22
February2014.50membersparticipated.
Dr.KavitaVJangam,AssistantProfessor,conductedWorkshop
on Psychosocial Preparedness in Disaster Management,
DepartmentofPsychiatricSocialWork,ChristUniversity,5-6
March2014.35membersparticipated.
Dr.ChittaranjanAndrade,Professor&Head,conducted(i)CME
on(a)DrugInteractionsinPsychiatry,IndianPsychiatricSociety,
Karnataka, Bangalore, 25 May 2013 (b) Psychopharmacology,
Postgraduates in Psychiatry and Medicine, Indian Psychiatric
Society,Kerala,Tiruvalla,18August2013(c)Psychopharmacology,
Venad Guild of Psychiatrists, Trivandrum, 10 November 2013.
(d) Recent Advances in Anxiolytic Pharmacotherapy, Indian
Association of Private Psychiatry, Gujarat, Ahmedabad, 16
February 2014 (e) Biostatistics for Psychiatric Research, Indian
PsychiatricSociety,Nagpur,1March2014.(f)Benzodiazepinesin
theManagementofAnxietyDisorders,IndianPsychiatricSociety,
Nagpur,1March2014(g)PsychopharmacologyforNeurologists,
Trivandrum Neuro Club, Trivandrum, 8 March 2014 (h)
Anxiety Disorders, Venad Guild of Psychiatrists, Trivandrum,
9 March 2014 (ii) Workshop on (a) Clobazam in Generalized
Anxiety Disorder, Seth VS General Hospital, Ahmedabad, 4
August2013(b)TreatmentOptionsinAnxietyandSomatoform
Disorders, Spandana Hospitals, Bangalore, 7 September
2013 (c) Recent Trends in Psychopharmacology, Visakha
Psychiatric Society, Vishakhapatnam, 10 September 2013 (d)
Psychopharmacology, Asha Hospital, Hyderabad, 11 September
2013 (e) Psychopharmacological Approaches to Anxiety
Management, Indian Psychiatric Society, Vijayawada chapter,
Vijayawada, 12 September 2013 (f) Clobazam in Psychiatry,
Mangalore Psychiatric Society, Mangalore, 21 September 2013
(g) Management of Somatoform and Generalized Anxiety
Disorders,BombayPsychiatricSociety,Bombay,5October2013
(h)OpipramolforSomatoformDisorders,MangalorePsychiatric
Society, Mangalore, 30 October 2013 (i) Two-day Workshop on
Cognitive Behavior Therapy in Psychiatry, DY Patil University,
Bombay, 16-17 November 2013 (j) Anxiety Disorders, Central
Travancore Psychiatric Society, Kottayam, 6 March 2014 (k)
Anxiety Disorders, Ernakulam Psychiatric Society, Cochin, 21
March 2014 (i) Drug Interactions in Psychiatry, Part 1, Grant
MedicalCollege,Bombay,22March2014(m)DrugInteractions
inPsychiatry,Part2,GrantMedicalCollege,Bombay,23March
2014 (n) Holistic Psychopharmacology in the Management of
Schizophrenia, Behavioral and Neuroscience Academy of India,
Bombay,23March2014
Dr. E Aravind Raj, Assistant Professor, conducted (i) CBHI
Training-Orientation course on Family of International
Classification (ICD-10 & ICF), Bangalore, 10 January 2014. 20
membersparticipated(ii)Workshopon(a)AwarenessofICD10,
Pariyaram Medical College, Kannur, Kerala, 29 January 2014.
200membersparticipated(b)AwarenessofICD10,PESMedical
College,Kuppam,20February2014.100membersparticipated.
Dr.NShivashankar,Professor&Head,Dr.NGirish,Additional
Professor of Epidemiology and Indian Speech and Hearing
Association-Bengaluru Chapter, conducted Interdepartmental
WorkshoponEarlyIdentificationofCommunicationDisorders
forANMandAnganvadiWorkers,HolurPHC,KolarDistrict,
13December2013.50membersparticipated.
Annual Report
Dr. N Shivashankar, Professor & Head and Department
of Community Medicine, MS Ramaiah Medical College,
Bangalore,conductedInterdepartmentalWorkshoponStroke
Rehabilitation, 19 April 2013. 35 Health workers and PHC
Doctorsparticipated.
III. Specific training underwent
by the faculty / staff
2013-14
NIIR
Dr. Rose Dawn Bharath, Associate Professor, 9 day training
on Functional MRI Connectivity and Resting State fMRI,
Dr.BharatBiswalNewJerseyinstituteoftechnology,Newark,
16-24January2014.
NEUROLOGY
CLINICAL PSYCHOLOGY
Dr. Keshav Kumar, Additional Professor, two day training
on workshop on Electrophysiology, Axxonet Brain Research
Laboratory,Bangalore,India,11-12January2014.
Dr. SR Chandra, Professor, (i) Introduction to Research
Methodology Biostatistics and SPSS, NIMHANS, July, 2013
(ii)ChennaiNeuroupdate2014-TraininginBOTOXinjections,
Chennai,26January2014.
Dr. Ravi Yadav, Associate Professor, Colloquim on Drug
ResistantEpilepsy,Bangalore,16-18August2014.
EPIDEMIOLOGY
Dr.VivekGupta,AssistantProfessor,underwent6weekstrainingon
DataManagementforClinicalResearch,UniversityofVanderbilt,
OnlineCourse(www.Coursera.org),November-December2013.
NEUROANAESTHESIA
Dr. KR Madhusudan Reddy, Professor & Head, one day
Workshop on TEE, Fortis Hospital, Cunningham Road,
Bangalore,12September2013.
Dr.MRadhakrishnan,AdditionalProfessor,(i)two-daytraining
onUSGandECHOinICU,ISCCM,Pune,11-12July2013.(ii)
two-daytrainingonECHOforHemodynamicmonitoring,Tata
MemorialHospital,Mumbai,08-09March2014.
Dr.SriganeshKamat,AssociateProfessor,onedayWorkshop
on TEE, Fortis Hospital, Cunningham Road, Bangalore, 12
September2013.
Dr.VSudhir,AssistantProfessor,onedayWorkshoponTEE,Fortis
Hospital,CunninghamRoad,Bangalore,12September2013.
NEUROCHEMISTRY
Dr. Srinivas Bharath MM, Additional Professor, Dr.
Nandakumar DN, Assistant Professor, 4-day training on 37th
Internal audit and Quality Management Systems Certificate
Course, Institute of Hotel Management, Bangalore, 19-22
September,2013.
Dr.SubasreeR, AssistantProfessor,(i)Thirdteachingcoursein
CognitiveNeurology,WorldFederationofCognitionDisorders
andAphasia,Bangalore,April2013(ii)FundamentalsofMass
Spectrometry based Proteomics for beginners: Workshop,
Bangalore,March-2014.
NEUROMICROBIOLOGY
Dr.RRavikumar,Professor&Head,(i)NABHAssessorsCourse
programmeonimplementation,AFMC,Pune,3-7June2013(ii)
Programme on implementation of NABH hospital standards,
ColumbiaAsiaHospital,Hebbal,Bangalore,26-28July2013(iii)
Board Review Course on Infectious Disease, SEPSIS Congress
2013, New Delhi, 4-5 December 2013 (iv) Sample preparation
for proteomics of Cryptococcus neoformans clinical isolates,
InstituteofBioinformatics,Bangalore,18-26March2014.
NEUROPATHOLOGY
Dr.YashaTC,Professor&Head,four-dayInternalAuditand
Quality Management training program for NABL Foundation
forQuality(India),InstituteofHotelManagement,Bangalore,
27-30July2013.
Dr. Anita Mahadevan, Additional Professor, (i) three-day
Training in Plastination Technique (Museum Technique for
Specimen Preservation), CMC, Vellore, 18-20 April 2013. (ii)
four-day Internal Audit and Quality management training
programforNABLFoundationforQuality(India),Instituteof
HotelManagement,Bangalore,25-28August2013.
Annual Report
2013-14
Dr. Sangeetha Seshagiri K, Sr. Clinical Pathologist, 4 Days
Internal Audit and Quality Management training program
for NABL Foundation for Quality (India), Institute of Hotel
Management,Bangalore,25-28August2013.
NEUROVIROLOGY
Dr.AnitaDesai,AdditionalProfessor,three-dayOrientationto
ISO15189:2012,Puducherry,19-21February2014.
Mr. Manjunatha MV, Sr. Scientific Officer, four-day FACS
MasterSortingTrainingCourse,BD-JHFACSAcademy,Jamia
HamdardUniversityCampus,NewDelhi,2-5July2013.
PSYCHIATRY
Dr. Muralidharan K, Associate Professor, 1 year visiting
Professorship- Mood Disorders Centre, University of British
Columbia,Vancouver,BCCanada,1July2012-30June2013.
Dr. Arun Kandasamy, Assistant Professor, four-day Course
on Leadership and Professional Development of Young Asian
Psychiatrists,Bangkok,20-23August2013.
Dr.VandanaVP,AssistantProfessor,WorkshoponRapidPrompting
Method,SpasticSocietyofKarnataka,Bangalore,15March2014.
Academic activities funded by Dr. Ramachandra N Moorthy Foundation
Dr. Ramachandra N Moorthy Foundation for Mental
Health and Neurological Sciences funded 14 events of
NIMHANS during the year 2013-14. The events are:
(i) Demonstration of ethical and legal guideline to
maintain standards of conduct within the profession,
Dept.ofNursing(ii)Anational-levelessaycompetition
for postgraduate students in psychology on the theme
“Psychologists as positive social change agents in
India: Ideas for action” (iii) Symposium on Mental,
neurological and substance use disorders and injuries
in workplace settings, Centre for Public Health (iv)
Two-day National symposium entitled Walking the
Line:EthicalissuesinPsychotherapyPractice,Dept.of
ClinicalPsychology(v)CaregiversSupport&Education
Programme Workshops, Psychiatric Rehabilitation
Services(vi)OnedayCME/symposiumonthepractice
Professional Skills Enhancement Workshop for NIMHANS faculty members
of electroconvulsive therapy for psychiatrists and
psychiatrytraineesinthecountry,Dept.ofPsychiatry(vii)OrientationProgrammeonMentalHealthandAddictionPrevention
for NSS Programme Officers, Dept. of Psychiatric Social Work (viii) World Mental Health Day celebrations, Psychiatric
RehabilitationServices(ix)Onedayworkshoponthepsychiatricemergencies,Dept.ofNursing(x)OnedayYouthConference
(YouthProActionLabs),followedbyhalfdayworkshoponInnovativeMethodsforMentalHealthPromotion(MindBlitz),
Dept.ofClinicalPsychology(xi)SecondEarlyCareerMentalHealthProfessionalsWorkshop,withProfNormanSartorius&Dr
MohanIsaac,January,2014(xii)ProfessionalSkillsEnhancementWorkshopforMid-levelFaculty,NIMHANS,January2014
(xiii)Aone-and-a-halfdayNationalConferenceonResearchandServicesinPsychiatricRehabilitation(xiv)SecondNIMHANS
RoyalCollegeofPsychiatristsConference,March2014.
Dr. Ramachandra N Moorthy Foundation for Mental Health and Neurological Sciences at NIMHANS was created through a
generousdonationbyDr.RamachandraNMoorthy,anIndian-bornPsychiatristinVancouver,Canada.Oneofthemajorgoalsofthe
FoundationistopromotetrainingandacademicactivitiesinthefieldofmentalhealthinIndia.ThetotaldonationwasaboutRs.3.35
crore,andithasbeendecidedtousetheannualinterestsgenerated(ofaboutRs.30lakh)forvariousacademicactivities.ACommittee
hasbeenformedundertheChairmanshipoftheDirector/ViceChancellorofNIMHANSandincludestheRegistrar,DeputyFinance
Officer,VisitingProfessorDr.MohanKIsaac,Dr.RamachandraNMoorthy,andfacultymembersfromthedepartmentsofClinical
Psychology,PsychiatricSocialWork,andNursing.TheMemberSecretarycoordinatestheactivitiesfundedbytheFoundation.
Central Facilities
Annual Report
2013-14
NEUROBIOLOGY RESEARCH CENTRE (NBRC)
Table 2: Awards and Publications
The Neurobiology Research Centre is a sophisticated common
research facility at NIMHANS. The objective is to promote
interdisciplinary research at NIMHANS as well as advance
inter-institutional collaborative research. The centre provides
infrastructure that supports translational research and
development of cutting edge technology in frontier areas of
neuroscience. Ithouses15researchlaboratoriesandfourcommon
centralfacilities.Mostofthelaboratorieshavereceivedextramural
grants for their research work; the funding sources being DBT,
DST,ICMR,CSIRandothers.ThemandateoftheNBRCisthat
all the central facilities and research laboratories are common
facilities,tobesharedandusedbyscientists,researchscholarsand
studentsatNIMHANS.Atotalof128students/researchscholars
arecurrentlyusingthefacility(62PhD,9MPhil,2post-doc,SSO,
SRF,JRF-41,14Trainees).Outof70researchprojectstakenupby
thecentre,19havebeencompletedand51areinprogress(Table
1).Thecentregenerated75peer-reviewedpublicationsandalso
baggedseveralawardsforitsresearchactivitiesinthereference
year(Table2).NBRChousesstate-of-the-artequipmenttocarry
out cutting-edge research. Various equipment and instruments
wereprocuredduringtheyear2013-14toaugmenttheresearch
capabilities (Table 3). Details of various laboratories and its
facilitiesaregiveninthefollowingparagraphs.
Laboratory
Awards
TranslationalPsychiatryLaboratory
Multi-modal Brain Image Analysis
Laboratory
MetabolicLaboratory
Neuro-OncologyLab
MolecularGeneticsLaboratory
BioinformaticsLaboratory
CellCultureandStemCellBiology
ElectrophysiologyLaboratory
OpticalImagingLab
NeuromuscularLaboratory
NeurotoxicologyLaboratory
Cognitive Psychology & Cognitive
NeurosciencesLaboratory
8
1
Total
Publications
20
7
Nil
1
1
1
2
1
Nil
1
Nil
1
1
9
4
8
2
7
1
14
1
1
TranslationalPsychiatry
Laboratory
Multi-modalBrainImage
AnalysisLaboratory
AdvancedFlowCytometry
Laboratory
MetabolicLaboratory
Neuro-OncologyLab
MolecularBiology
Laboratories-Communicalble
andNon-Communicable
MolecularGenetics
Laboratory
CognitivePsychology&
CognitiveNeurosciences
Laboratory
Laboratory
TranslationalPsychiatry
Laboratory
Multi-modalBrainImage
AnalysisLaboratory
AdvancedFlowCytometry
Laboratory
MetabolicLaboratory
Neuro-OncologyLab
Table 1: Research projects during the year 2013-14
Laboratory
Table 3: Purchase of equipment during the year 2013-14
TOTAL (including
non-funded
projects)
Com- Ongo- Com- Ongopleted
ing
pleted
ing
Funded
projects
Nil
10*
Nil
12
1
4
1
4
Nil
4
Nil
4
1
2
1
3
2
5
1
5
Nil
1
1
2
1
4
2
5
4
1
7
5
7
1
12
5
Nil
1
Nil
1
MolecularBiology
Laboratories-Communicable
andNon-Communicable
MolecularGeneticsLaboratory
CellCultureandStemCell
Biology
ElectrophysiologyLaboratory
OpticalImagingLab
Equipment purchased
Workstationcomputerand
serverforimageanalysis
TwoworkstationsforMRI
analyses;andarefrigerator
AdvancedfourlaserBDFACS
AriaIIIcellsorterandathree
laserFACSVerseanalyzer
Nitrogengenerator
HPWorkstationwithHPall
-in-one1005laserJetPrinter
forhighthroughputstatistical
analysis;ENDUROTMGDS
ImagingSystemalongwith
APCBR1000UPSSystem;
Cytovisonsoftwareupdate,
Fluorescentmicroscopefilters.
LiquidNitrogentank(YDS-65216)forcryopreservationof
clinicalsamples.
CO2Incubator;Inverted
microscopefortissueculture;
Pyromarksequencer;PCR
machine
OrbitrapFusionMass
spectrometer
HorizontalLaminarAirFlow
Unit,CO2Incubator,pHmeter
MEASystem
Doublepatchstar
micromanipulatorsystemfor
patchclamp;Vibratome;CO2
incubator
*OneCentreofExcellenceproject
2013-14
Annual Report
Laboratory
NeurotoxicologyLaboratory
CognitivePsychology&
CognitiveNeurosciences
Laboratory
Equipment purchased
-80°Cfreezer,Refrigerated
centrifuge,Dewarsflask,
Vortexmixer,Sonicator,
Cryostat,Waterbath,Multiwell
platereader
-200°CFreezer;-40°C
refrigerator;imagingsystem
formicroscope;laminarflow
chamber;liquidnitrogen
container.
Noisecancellationhead
phones;Cortisolreagentkits
withcalibratorsandcontrols
(foratotalof360sample);Bi
Spectralindex(BIS)electrodes
Common Facilities
A.
Human Brain Tissue Repository (Human Brain
Bank) (Officer In-charge: Dr. SK Shankar)
The Human Brain Bank located in the ground floor of
Neurobiology Research Centre, has continued the mandated
activities of (a) collection of donated brains from cases of
Neurodegenerative and Infective conditions (b) collection of
brains from victims of Road Traffic Accidents, as relatively
normal controls (c) Distribution of the brain tissue, CSF and
serumforinvestigativestudies.
During the year 2013-2014, brains were collected from cases
of schizophrenia, stroke, brain mass lesion, HIV and TBM.
In addition, 32 fresh brain biopsy samples following epilepsy
surgerywerecollectedandstoredonlyaftertakingthetissuefor
diagnosticwork.Fortyfourcadaverheartsfromvictimsofroad
traffic accidents were collected and provided for homograft
transplantation to Jayadeva Institute of Cardiology and
ResearchCentre,ManipalHospitalandNarayanaHrudayalaya.
Required brain tissues from various anatomical areas, CSF
samples from normal controls and diseased states were
distributedto15scientistsfortheirresearchworkthroughout
India. In collaboration with Institute of Bioinformatics,
proteomics studies were continued in cases of tuberculous
meningitis, cryptococcal meningitis, toxoplasma encephalitis,
cerebral malaria, rabies encephalitis and schizophrenia. In
thesestudies,someseminalobservationswerereported.
Cadaveric temporal bones collected from unclaimed bodies
with the permission of the Police were provided to the
Department of ENT of Commando Hospital, Bangalore for
teachingpurposes.
Table 4: Samples stored during the year 2013-2014
Sl.No.
Details
1
Freshbrainscollected*
2
Numberofformalinfixedbrains
(TBM-01;HIV-02;Psychiatric
(Schizophrenia)-02;Stroke-02;
PulmonaryEmbolism-02;Rt.
ParietalMassLesion-02;Glioma-01;
Normal–01)
3
CSFandSerumsamplesfrozen
4
FreshtissuesfrozenfromAutopsy/
Biopsy(BrainBiopsy-32;HIV-01)
5
AntemortemBloodSamples
Collected(13/HIV/C206,13/N/S156,
13/HIV/S165,CJD-Nil)
6
BloodSamplesCollectedforDNA
Extraction
7
Freshheartscollectedfrommedico
legalautopsiesforvalve/aorta
homograftcollectedwithin6-20hrs
ofpost-mortemandhandedoverto
surgeons.
8
BloodSamples(Serum,Plasma,Buffy
Coat)/CSFcollectedforothertests
Total No.
06
13
13
33
03
55
54
44
BrainBankisactivelyinvolvedinthepromotionofneuroscience
research and public awareness programmes, especially about
neurologic disorders, cadaver organ donation and brain
donation. Human brain specimens are provided to various
schools and colleges for demonstrating them to the general
public, thus enhancing their participation. Neuroinfection
teaching slides have been provided to various premier
institutionsacrossthecountry.
The staff of HBTR participated in the annual conference of
IndianEpilepsyAssociation,BangaloreChapterasvolunteers.
About 950 schoolchildren and 100 teachers from 9 schools
visitedtheexhibitionheldduringtheconference.
AspartofthepublicawarenesseventheldonOrganDonation
Day, green ribbons were distributed on 6 August 2013. Sixty
seven research scholars and trainees working in various
sectionsofNRCandadministrativestaffpledgedtheirorgans/
brain by signing the consent form and donor card. Healthy
HeartAssociationofBangalorefelicitatedDr.SKShankarand
Dr.AnitaMahadevanfortheircontributioninpopularizingthe
organdonation,brainbankingandpromotionofneuroscience
inschoolsandcolleges.Sevenresearcharticleswerepublished
duringtheyearutilizingthematerialsoftheBrainBank.
Classes in Neuroanatomy and Neuropathology are being
conductedasapartofthePhDNeurosciencemodule,andfor
Annual Report
theDM/MCh/MDPathologystudentspostedtotheDepartment
ofNeuropathology.
B.
Neuropathology Brain Museum (Dept. of
Neuropathology; Head: Dr. Yasha TC, Officer Incharge-Prof. SK Shankar)
TheNeuropathologyBrainMuseum(HumanBrainMuseum),
the only one of its kind in the country, is located in the
NeurobiologyResearchCentre.Thisuniquefacilityhasbecome
acentreofattractionforschoolandcollegestudents,servingas
avaluablesourceofNeurosciencematerials.
TheNBRCisalsoprovidedwithadedicatedcentralwastedisposal
facilityinthegroundfloorwhichisequippedwithalargevolume
autoclaveandashredderforhospital/labwastedisposal.
During the year 2013-2014, the NBRC acquired a liquid
nitrogen storage tank of capacity 900 litres. This is a source
of supply for liquid nitrogen which is being used regularly by
several laboratories at NBRC. This facility is also being used
routinely by some laboratories in the administrative block
such as Departments of Neurovirology, Neuropathology,
Neurochemistry,NeurophysiologyandBiophysiscs.
D.
Themuseumsawexponentialgrowthintermsofvisitornumbers
(Graph 1.). During the review year, the number of visitors
stood at 3208 (General public/patients at NIMHANS-423;
organization representatives/dignitaries-115; press/media
persons-9;residentsatNIMHANS,researchscholars,Nursing
students, staff, and others-1435). Many foreign scientists and
dignitaries,whocametoNIMHANSforscientificcollaboration,
visited the Neuropathology Brain Museum and greatly
appreciatedtheuniquecollectionandthemeansofdisplay.
4000
3000
2000
1000
0
2010-2011
2011-2012
2012-2013
2013-2014
Graph 1: Visitors to Neuropathology Brain Museum (from 2011 to 2014).
Human brain, spinal cord and other parenchymal organs
are displayed at the museum, providing the visitors a unique
experiencetotouchandfeeltheseorgans.ThestaffofHuman
Brain Bank regularly conducts guided tour for the visitors,
explainingthenatureandimportanceofspecimensexhibited.
C.
Central Facility for Millipore Water Purification
System, Liquid Nitrogen and Waste Disposal
A new high capacity Millipore (ELIX 70 Ltr/Hr and Synergy)
water purification system has been installed in the ground
floor that provides purified water for multiple laboratory and
hospital applications, including ultrapure water required for
molecularbiologyresearch.
2013-14
Centre for Advanced Research for Innovation in
Mental Health and Neurosciences – Funded by
Department of Health Research (DHR), Ministry
of Health and Family Welfare, Govt of India and
Indian Council of Medical Research (ICMR-2014)
The ICMR Centre for Advanced Research at NIMHANS
was conceptualized during the visit of Hon’ble Minister of
Health and Family Welfare, Govt. of India to NIMHANS
inJanuary2011.Realizingtheleadershippotentialshown
and the rapid progress made by NIMHANS in the field of
Mental Health and Neurosciences, Department of Health
Research(DHRandICMR)decidedtoestablishtheCentre
for Advanced Research for Innovation of Mental Health
and Neurosciences with a dual component of manpower
development to achieve a critical mass of technical
person and propel translational research to take scientific
investigation to the bedside medicine. The vision of the
Centre for Advanced Research for Innovation of Mental
Health and Neurosciences supported by DHR and ICMR
at NIMHANS is “to be a leader in the field of mental
health and neuroscience and evolve the state-of-the-art
technology and innovation for translational research and
developcriticalmassofmanpowertomeetnationalneeds
byscientificcollaborationandco-operation”.
The Centre was inaugurated on 26 March 2014 by Dr. VM
Katoch,DirectorGeneralofIndianCouncilofMedicalResearch,
NewDelhi.TheAdvancedCentre,locatedinthethirdfloorof
Neurobiology Research Centre, presently has three projects
sanctionedafterevaluationbytheexpertcommittee.‘Anatlas
ofcommoninfectionsofnervoussystemwithasetofteaching
slides’andabookletdevelopedbytheHumanBrainBankwere
releasedontheoccasion.
Annual Report
2013-14
Research Laboratories
Translational Psychiatry Laboratory
charge: Dr. G Venkatasubramanian)
Multi-modal Brain Image Analysis Laboratory
(MBIAL) (Officer In-charge: Dr. John P John)
(Officer
In-
The Translational Psychiatry Laboratory (TransPsych
Lab) facilities have been created towards initiation of an
integratedclinicalresearchfacilitywithfocusontranslational
applications in psychiatry. This research facility is supported
byresearch grants from Welcome Trust /DBTIndiaAlliance
Senior Fellowship Award as well as from the Department
of Biotechnology. The goal of the TransPsych Lab is to
evaluate and establish composite biomarkers involving
neuroimmunobiological abnormalities in Schizophrenia and
other disorders like Obsessive Compulsive Disorder, Bipolar
Affective Disorder and Alzheimer’s disease. The vision of
this Centre is to create a translational research facility of
internationalcaliber,integratingclinical,neuroimmunological,
neuropathological,neuroimagingandadvancedcomputational
researchtechniquestoexaminethe‘Neuroimmunopathogenetic
ModelforSchizophrenia’.
Completed research activities:
Research activities completed during the year 2013 – 2014
include evidence for brain derived neurotrophic factor
abnormalities in schizophrenia, clinical & neurobiological
studiesontheeffectoftranscranialDirectCurrentStimulation
(tDCS) in schizophrenia, hippocampal & superior temporal
gyrus abnormalities in schizophrenia, structural brain
abnormalities in obsessive-compulsive disorder (OCD),
functional MRI studies involving symptom provocation
paradigminOCD.
Ongoing research activities:
Ongoing research activities focus on examining the
Neuroimmunogenetic and neuroplastic correlates of brain
abnormalities in schizophrenia, neuromodulatory effects
of tDCS in schizophrenia, eye movement abnormalities
in schizophrenia and OCD, EEG/ERP abnormalities in
schizophreniaandOCD,neurohemodynamicabnormalitiesin
schizophreniausingfunctionalNearInfraredSpectroscopyand
imaging-geneticsstudiesinOCD.
Patient Care Services:
TransPsych Lab critically facilitates provision of transcranial
direct current stimulation for schizophrenia patients (n=46).
Researchstaffinthelabcontributestotheclinicalservicesof
theschizophreniaclinicaswellasthemetabolicclinic.
This laboratory aims at integrating the acquisition and
analysis of multiple modalities of brain imaging for a more
comprehensiveunderstandingofbrainstructure,functionand
signalling in various neuropsychiatric disorders. This facility
aims at employing an integrated multi-disciplinary approach
toexaminebrainstructureandfunctioninhealthanddisease
through active collaborations between various departments
both within and outside the institute. Research projects
being undertaken at MBIAL include multi-modal imaginggenomicsstudiesinschizophreniaanddementia,aswellasof
certain cognitive processes; these projects are funded by the
DepartmentofScienceandTechnology(DST)andDepartment
ofBiotechnology(DBT).ManyPhDscholars,MD(Psychiatry)
post-graduates as well as trainees from other departments of
NIMHANSaswellasexternaltraineeshaveutilizedthefacility
forobtainingtraininginvariousaspectsofmulti-modalimage
acquisitionandanalysis.
(a) EEG power spectral and complexity analyses
in neuroleptic-naïve patients with recent-onset
schizophrenia
(b) Novellandmark-baseddefinitionoftherostralprefrontal
cortexandevidenceforneurodevelopmentaldevianceof
therostralprefrontalcortexinschizophrenia
(c) Corpus callosal abnormalities in schizophrenia and
genderdimorphismofcorpuscallosum
(d) MRI brain activations and deactivations during word
generationandaberrationsofthesameinschizophrenia
(e) Development of a task-based ensemble synchrony
measureofEEGusingFrobeniusnorm
Presently,themajorthrustareasofresearchatMBIALinclude:
(i) multi-modal imaging-genomics approach to investigating
the link between impaired word generation and aberrant
glutamatergic function in schizophrenia; (ii) examination of
aberrantneuralsynchronyinschizophreniausingEEG,fMRI
and polysomnography; (iii) study of the link between blood
biomarkersandneuroimagingparametersinschizophrenia;(iv)
examinationofthelinkbetweencandidategenepolymorphisms
andneuropsychologicalandinformationprocessingdeficitsin
schizophrenia; (v) network connectivity in minimal cognitive
impairmentandearlydementia;(vi)defaultmodenetworkand
cognitioninhealthyageing;(vii)diffusiontensorimagingand
Annual Report
apoEpolymorphismsinAlzheimer’sdementia;and(viii)neural
correlatesofwell-beingassociatedwithmindfulnessmeditation
and(ix)structureandfunctionoftherostralprefrontalcortex
(BA10).
Advanced Flow Cytometry Laboratory (Officer Incharge: Prof. V Ravi)
2013-14
Thephenotypic,electrophysiologicalandradiologicalfeatures
ofchildrenwithinbornerrorsofintermediarymetabolismwere
evaluated by a cross-sectional, retrospective-cum-prospective
hospital-based study as a part of DM Neurology dissertation
work.
The Advanced Flow Cytometry Laboratory enables sorting
and analysis of single cells based on multiple parameters
respectively. Students / researchers from the Departments of
Neurovirology and Neuropathology use this facility for their
researchworks.
Ahigh-throughputmassspectrometry-basedscreeningtestfor
Gaucher, Pompe, Niemann-Pick, Krabbe and Fabry diseases,
using dried blood spots, has been established. Using this
method,samplesarebeingtestedtodeterminetheprevalence
ofthesedisordersintheIndianpopulation.
Completed research activities
Innate Immune Mechanisms in Japanese Encephalitis Virus
Infection(PhDthesisbyPrachiRFadnis)
Patient care services:
3558 samples were screened for IEM using tandem mass
spectrometry
(a) A Comparative Study of Innate and Cell Mediated
Immune Responses in Human Immunodeficiency virus
infectedindividualswithandwithoutNeurotuberculosis
(b) Clinical and immunological profile of patients with
SubacuteSclerosingPanEncephalitis
(c) Flow cytometry based detection of dysferlin protein
expression in CD14 positive monocytes from peripheral
bloodsamplesofpatientswithDysferlinopathy
(d) Analysisofbraininfiltratinglymphocytesinmousebrain
following vaccination against Rabies or infection with
Rabiesvirus.
(e) Analysis of cellular immune responses in patients with
Schizophrenia.
Neuro-Oncology Lab (Officer In charge: Dr. Vani
Santosh)
Metabolic Laboratory (Officer In-charge: Dr. Rita
Christopher)
ThisLaboratoryconductshigh-throughput,massspectrometry
(MS)-basedscreeningforInbornErrorsofMetabolism(IEM).
In a drop of blood collected on filter paper, 40 analytes are
measuredincluding10aminoacids,freecarnitineand29acyl
carnitines. Based on the characteristic profiles, inborn errors
of amino acid metabolism, fatty acid oxidation defects and
organic acidemias are identified. This facility, which is the
firstofitskindinagovernmentset-upinthecountry,attracts
samplesfromalloverIndiaaswellasfromotherneighbouring
countries. The lab has obtained 100 per cent satisfactory
resultsintheNewbornScreeningQualityAssuranceProgram
conducted by the Center for Disease Control and Prevention
(CDC),Atlanta,USA.
The Neuro-Oncology Lab was established in September 2011
with a prime objective of translational research in NeuroOncology. In addition to tissue based research carried out at
the lab, collaborations with core biological research institutes
have promoted dissection of various pathways related to
gliomagenesis.
Research activities completed during the year 2013-2014
include studying the role of novel biomarkers; STAT-1,PP1A,
MMPs and SOD2 in the pathogenesois and prognosis of
glioblastoma,patho-biologicalcharacterizationofWHOgrade
IIIgliomas,usingvariousmarkersbytechniquessuchasIHC,
FISH and PCR studies. Tissue microarray (TMA) blocks for
several gliomas, meningiomas, medulloblastomas have been
builtandIHCvalidationsarebeingcarriedoutontheseTMA
sections.
The prognostic relevance of various molecules involved
in possible radiation resistance such as NNMT, MELK,
Osteopontin,etc.isbeingcurrentlyevaluated,andthepotential
role of few of the molecules as a serum biomarker in GBM
explored. To evaluate the role of the molecules associated
withglioblastomatumorinvasionandrecurrence,28casesof
coreandtumorperipheryinglioblastomahavebeenarchived,
and their histological characterization has been completed
and further biological studies are in progress. Other studies
Annual Report
2013-14
in the lab include relation between the Clinico-Pathological
properties of meningiomas and their chromosomal deletion
statuses as diagnosed by FISH studies and characterisation
of novel biomarkers such as IMP3, SOX2, CSNK2-α, p65 on
varioustissuesamplesofglioblastoma.Inaddition,phosphoproteomicsworkinMedulloblastomaincollaborationwithIOB
hasbeeninitiated.
1p19q status using FISH technique is routinely performed in
thelab.Atotalof50patientsampleswerestudiedandreported,
during the year under review. MGMT methylation status for
diagnosticpurposewasperformedonfivepatientsamples.
Molecular Biology Laboratories-Communicable and
Non-Communicable (Officer In-charge: Prof. V Ravi)
The Molecular Biology labs (Communicable and NonCommunicable Disease labs) are being used routinely
by students from various departments at NIMHANS
namely Human Genetics, Molecular Genetics, Biophysics,
Bioinformatics,
Neuropathology,
Neurochemistry,
Neurovirology, Neurophysiology, Neuromicrobiology, etc
either for performing Real Time PCR / Conventional PCR
assaysorforanalysisofgels/blotsonthechemiluminescence
enabledGelDocumentationsystem.Tworoomsinthisfacility
arebeingusedforCellcultureworkbytheMolecularGenetics
Lab.
Faculty and students in the two laboratories are carrying out a
comparativestudyofinnateandCellMediatedImmuneResponses
inHumanImmunodeficiencyvirusinfectedindividualswithand
withoutNeurotuberculosis,studyingthemolecularaspectsofthe
pandemicInfluenzaA2009(H1N1)viruswithspecialreferenceto
hostimmunefactors,offeringmoleculardiagnosisforDengueand
studying the epidemiology of Dengue virus and innate immune
responsesinJapaneseEncephalitis.
EvaluationofDenguediagnosisbyconventionalandRealtime
PCRassaysandDengueVirusEpidemiologystudies.
Molecular Genetics Laboratory (Officer In-charge:
Prof. Sanjeev Jain)
The Molecular Genetics lab has been involved in several
researchandmoleculardiagnosticsprojectsinneuropsychiatric
disordersincludingschizophrenia,dementia,OCD,alcoholism,
spino-cerebellar ataxia, muscular dystrophy, etc. In addition
to candidate gene studies using case control association,
lymphoblastoidcelllinesarebeingderivedfrompatientblood
lymphocytestohaveapermanentsourceofDNAandalsouse
it as a model system. PBMCs are isolated from whole blood
and transformed with EBV to derive LCL lines. Epigenetic
studieshavebeeninitiatedonalcoholsamples.Therehasbeen
significant overlap and exchange of knowledge between the
clinicandthelabviainteractions.
A project involving telomere length in dementia and
Huntington’sdiseasehasbeencompleted.
Tissuecultureworkhasbeeninitiatedforthedevelopmentof
lymphoblastoid cell lines as model systems to study disease
biology.UndertheDST-inspireprogramme,Dr.BijuViswanath
has been working in the laboratory on ‘Imaging-genomics
approach to identify molecular markers of Lithium response
in bipolar disorder’. A post-doctoral fellow working in Centre
for addiction medicine is carrying out his dissertation in the
laboratoryontheepigeneticsofalcoholism.
Atotalof125individualsandtheirfamiliesavailedtheservices
forgeneticcounsellingandtestingforthelateonsetmovement
disorders (HD/SCA). MLPA method of analysis on the DNA
sequencer has been standardized for diagnosis of Duchenne
musculardystrophyandtested55individualsweretestedinthe
yearunderreview.Inaddition,testingforSMAfor16samples
wascarriedout.
Bioinformatics
Laboratory
(Officer
Dr Keshav Prasad, Dr. SK Shankar)
In-Charge:
The Bioinformatics and Proteomics Laboratory is actively
involved in genomic, proteomic phospoproteomic and
glycoproteomic analysis of various human tissues to
understand the cellular biology. The main areas of thrust at
thislaboratoryarestudyofchronicmeningitisliketuberculous
meningitis, cryptococcal meningitis, and rabies encephalitis.
In collaboration with the Department of Neurovirology, the
scientists have studied temporal evolution of mouse brain
proteome in response to rabies infection. They demonstrated
dysregulationofchemokineandinterleukinreceptorpathways
in addition to large number of protein involved in synaptic
vesicle exocytosis and RNA processing. They also evaluated
Annual Report
quantitative proteomic of various types commercially
availablerabiesvaccines.IncollaborationwithDepartmentof
Neurochemistry, quantitative proteomics and glycoproteomic
analysisofcerebralstrokeandischemicstrokehasbeencarried
out. In addition the laboratory is involved in studying the
proteomicalterationsincerebralheadinjuryandsomeofthe
neuromusculardisorders.
Quantitative proteomic analysis of brain tissue samples
from cryptococcal meningitis patients co-infected with
HIV and toxoplasma encephalitis patients co-infected with
HIV was carried out to identify molecules involved in host
response and identified 260 and 180 differentially expressed
proteins, respectively when compared to tissues from
uninfected individuals. Proteomics, proteogenomics and
phosphoproteomicstudiesofCryptococcus neoformansusing
highresolutionmassspectrometryhavealsobeencarriedout.
Proteome of human pituitary glands has been mapped and a
totalof2,286proteinsidentified.
The proteins altered in chronic meningitis are being profiled
using brain tissue and CSF samples. In addition, temporal
analysis of rabies virus infected mouse cerebrum and cell
lines such as BHK21 and neuro2A has been performed.
Glycoproteomicanalysisofserumsamplesfromischemicand
hemorrhagicstrokehasalsobeenperformed.
Cell Culture and Stem Cell Biology Laboratory (Officer
In-charge: Dr. TR Raju)
expression of NF-H in NSC-34 cells upon exposure to
ALS-CSFwasfound;howevertheexpressionofNF-Lwas
up-regulated when compared to the control groups viz.
NCandNALS.
(b) Quantitative proteomic analysis by iTRAQ labelling
was carried out to identify toxic factors present in CSF
of Amyotrophic Lateral Sclerosis patients (ALS-CSF).
The mass spectrometry results of 10 ALS-CSF samples
compared with 10 normal CSF samples from patients
undergoing orthopaedic surgery (N-CSF) showed upregulation of approximately 31 proteins (showing
morethan1.5foldincrease)and17proteinsweredown
regulated (showing less than 0.5 fold decrease) in ALSCSFsamples.Thefourproteins(chitotriosidase(CHIT),
osteopontin, chitinase-3-like protein 2 and chitinase-3likeprotein1),up-regulatedinALS-CSF,werevalidated
usingELISA.CHITactivityalsoshowedatenfoldincrease
in ALS-CSF. Immunostaining revealed that microglial
cells exposed to ALS-CSF expressed CHIT, but not the
astrocytes.AlltheseresultsindicatethatCHITmayplay
animportantroleinpathogenesisofALS.
(a) MitochondrialdysfunctioninthesporadicmodelofALS
has been investigated. Proteomics of the mitochondrial
proteins from the spinal cords of ALS-CSF injected
animals revealed up-regulation and down-regulation of
several key proteins, thereby identifying the pathways
whichleadtomitochondrialdysfunction.
(b)
Proteomics analysis of ALS-CSF revealed up-regulation
ofChitotriosidase(CHIT-1)comparedtonormalCSF.The
levelofCHIT-1wasfurtherevaluatedbyELISAinalarger
cohort of patients’ CSF, which showed a 17-fold increase
in the CSF of ALS patients. To determine the biological
significanceoftheup-regulatedCHIT-1,itseffectonNSC34motorneuronalcelllinewasinvestigated.CHIT-1didnot
haveadirecteffectontheviabilityofNSC-34cellsasshown
by MTT assay. The effect of CHIT-1 on the non-neuronal
cellsviz.astrocytesandmicrogliaisbeinginvestigated.
(c)
PrimaryastrocyteswereexposedtoCSFfromALSpatients
(ALS-CSF)andcomparedwiththenormalcontrols(NC)
andNon-ALS(NALS-CSF).Thestudiesrevealedadownregulation of trophic factors VEGF and GDNF in ALS,
while inflammatory markers like IL6, and TNF-α were
foundtobesignificantlyup-regulated,suggestingtherole
ofneuroinflammationintheexacerbationofthedisease.
Thislaboratoryiswellequippedwithadvancedinfrastructure
and technology. Currently primary cultures of motor
neurons, astrocytes, microglia, olfactory bulb and cell lines
of motor neurons (NSC-34), Dopaminergic neurons (N27),
Neuroblastoma(SHSY5Y)andglioblastoma(U251MG,U87MG)
are grown in the cell culture laboratory. These cell lines are
usedascellularmodelsystemtodelineatethepathogenesisof
ALS,Parkinson’sdiseaseandGlioma.Severalfundedprojects
arebeingexecutedinthislaboratory.
(a) To investigate the possibility that aggregation of
phosphorylated neurofilaments might have occurred
due to the deranged expression of the neurofilament
subunits,theexpressionofsub-unitsNF-HandNF-Lin
NSC-34 cells was examined upon exposure to ALS-CSF
by immunocytochemistry and Western blotting. Stable
2013-14
Annual Report
2013-14
Culturesrichinmicrogliawerederivedfromembryonic
ratspinalcords.Up-regulationofchitotriosidase(CHIT)
was also observed in the microglial cultures exposed
to ALS-CSF. Reduced trophic support and enhanced
activation of microglia with up-regulated CHIT, an
indicator of neuroinflammation hints at crucial role of
astrogliaandmicrogliainelicitinginflammatorycascades
intheneurodegenerationassociatedwithALS.
Electrophysiology Laboratory (Officer In-charge: Dr.
BS Shankaranarayana Rao)
The electrophysiology laboratory is engaged in studying the
synaptic plasticity mechanisms in various animal models
of neurological and psychiatric disorders in various animal
models of neurological and psychiatric disorders are being
studiedusinglivebrainslicesofthehippocampusandmedial
prefrontalcortex.Inaddition,microelectrodearraytechnology
has been used for in vitro recording of electrophysiological
activity of neurons over a long period of time. The effect
of BDNF on electrophysiological activity of olfactory bulb
neuronal populationhasbeenstudied.
Researchers in the lab have studied the role of amygdala
in the modulation of hippocampal and prefrontal cortical
functionsinstress:Implicationsforthetreatmentofaffective
disorders,roleofescitalopramandreboxetineantidepressants
on hippocampal neurogenesis and structural plasticity in
endogenousanimalmodelofdepression,cellularandmolecular
basis of epilepsy-induced cognitive deficits, role of enriched
environment and antidepressant treatment on depression
induced cognitive deficits, regulatory role of amygdala on
hippocampalandfrontalcorticalfunctionsinstress,enriched
environmentexposurerestoresimpairedhippocampalsynaptic
plasticity in chronically restrained rats and protective effect
of Celastrus paniculatus Willd oil on chronic stress-induced
cognitiveimpairmentinadultmaleWistarrats.
Ongoing research activities include studies on the cellular
and molecular basis of endogenous depression induced
cognitive deficits, antiepileptic activity of medicinal plants in
animal models of Epilepsy; Effect of Celestrus paniculatus
oncognitivedeficitsinchronicallystressedrats:Abehavioral,
neurochemical, structural and electrophysiological approach,
cellular,molecularandelectrophysiologicalbasisofdepressioninduced cognitive deficits, role of enriched environment and
antidepressants on chronic stress-induced depression and
cognitivedeficits,amygdalainstress-inducedcorticalplasticity,
enriched environment and antiepileptic drugs on epilepsyinduced cognitive deficits, depression-induced cognitive
deficits: Effect of modulation of glutamatergic transmission
andbrainstimulationreward.
Optical Imaging Lab (Officer In-charge : Dr. Preeti Joshi)
This laboratory is an advanced facility for conducting
sophisticated experiments such as real time recording of
signallingeventsincellsandtissue.Thelaboratoryisequipped
withconfocalmicroscope,epifluorescencesystemsforimaging
andpatchclampsetupforelectricalrecordingfromcells.These
state-of-the-arttechniquesarebeingusedbytheresearchersto
unravel the cellular and molecular basis of physiological and
pathological signalling in the nervous system. The long-term
objective of the research is to identify the defective signalling
modules and its origin at molecular level (ion channels/
receptors etc.) in neuro-psychiatric disorders. This can be
translated into targeted therapy by developing drugs against
theidentifiedmoleculartargets.
Researchers in this laboratory are currently focussing on the
roleofglialcellsinepilepsy,intraandintercellularsignaling
aberrations in neuropsychiatric disorders and pain sensation.
Itwasfoundthatseveralmetabotropicpurinergicreceptorsin
astrocytesareupregulatedwithin1-2hrsofstatusepilepticus.
Astrocytes elicit hyper Ca2+ activity independent of neuronal
activity. Experiments on neuron-astrocyte cross talk show
that activation of P2Y2 receptors in astrocytes significantly
enhances the hyperactivity in neurons. To investigated the
changes in cellular signaling in dementia patients we have
studied the signaling events in lymphoblasts derived from
dementiapatientscarryingdifferentallelesofApoEgene.
Someoftheprojectsinthislabareincollaborationwithdepartment
of Neurology and department of Psychiatry. A new project on
understandingthemechanismsofneuropathicpainandexploring
newtherapeutictargetswasinitiatedincollaborationwithBristol
Myers Squibb Company (BMS) USA and Biocon Bristol- Myers
Squibb R & D Centre Bangalore. The Research projects for this
laboratoryarefundedbyDBTandBMS.
Neuromuscular Laboratory (Officer In-charge: Dr. AB
Taly)
The Neuromuscular Laboratory was conceptualized with the
objectivesofprovidingmoleculardiagnosisforneuromuscular
Annual Report
disorders (muscular dystrophies, spinal muscular atrophy,
myotonic dystrophy, and mitochondrial disorders),
immunodiagnosis for immune mediated disorders, skin
punchbiopsiesforassessmentofsmallfibreneuropathiesand
moleculardiagnosisforhereditaryandinfectiousneuropathies.
During the year, the research work has been translated into
14 publications in peer reviewed National and International
journals.
The research staff of Neuromuscular laboratory have assisted
the Department of Neuropathology by performing muscle
immunohistochemistryformusculardystrophies-141cases.In
collaboration with Neurotoxicology laboratory, Immunoblots
for 8 cases and Respiratory Enzyme assays for 60 cases were
carriedout.
Neurotoxicology Laboratory (Officer In-charge: Dr.
Srinivas Bharath)
The Neurotoxicology Laboratory focuses on investigating the
mechanisticandtherapeuticaspectsofneurotoxicmodelswith
implicationsfordegenerativediseases.Thelaboratoryemploys
biochemical,proteomicandepigeneticmethodstounderstand
thetoxicologicalbasisofdiseaseandtheroleofoxidativestress
andmitochondrialdamage.
One of the projects completed during 2013-14 involved a
comparisonofbiochemicalandproteomicalterationsinbrain
mitochondria of prepubertal and adult mice exposed to the
neurotoxin3-nitropropionicacid(3-NPA).
(a) A new project sanctioned during 2013-14 involved
analysis of the epigenetic regulation of red/ox
mechanisms in neurotoxic models of Parkinson’s
disease involving investigation of the role of chromatin
modifications (Funded by DST). The other aspect is to
testnaturalproductsandtheirderivativeswithpotential
neuroprotectivefunction,withtherapeuticpotential.One
of the ongoing projects investigates the neuroprotective
effects of nanoassisted C60-pyrimidine derivatives in
neurotoxicmodelsofParkinson’sdisease.
(b)
In addition, several diagnostic tests have been
standardizedandthetechnicalknow-howtransferredto
theNeuromuscularLab(NML).
No.
1.
2.
3.
4.
5.
(c)
Name of the test
WesternblotforCalpain-3
WesternblotforDysferlin
Westernblotforα-
Dystroglycan
WesternblotsforTelethonin
Enzymeassaysfor
respiratorycomplexes:I,
II,III,IV,Vandcitrate
synthase
(Respiratorycomplexwork-up)
2013-14
Disease
Calpainopathy(AR-LGMD2A)
Dysferlinopathy(AR-LGMD2B)
α-Dystroglycanopathy
(AR-LGMD2I)
Telethoninopathy
(AR-LGMD2G)
Mitochondrialdisorders
(MELAS,CPEO,MERRF,
Leigh’ssyndromeetc.)
Development of a cost-effective western blot reagent
withpotentialdiagnosticuse:Westernblottingisavery
commonandpowerfultechniqueemployedinbiomedical
research and diagnostic laboratories to detect specific
proteins in a mixture, using antigen antibody reaction,
on a membrane filter. To facilitate increased sensitivity
in this technique, there are several chemiluminiscencebaseddetectionreagentsthatarecommerciallyavailable.
However, the higher price of such commercial reagents
poses a major hurdle in those laboratories carrying out
western blotting on a daily basis. To circumvent this, a
costeffective,enhancedchemiluminiscencekithasbeen
standardized by critical modification of a published
protocol to achieve higher sensitivity and long-term
storage, comparable to commercial reagents. Extensive
testinginourlaboratoryandothersatNRChasconfirmed
the sensitivity of the reagent comparable to commercial
reagents.The Centre proposes to donate this reagent, on
a regular basis, free of cost for any western blot-based
test carried out from NIMHANS.
Cognitive Psychology & Cognitive Neurosciences
Laboratory
(Officer
In-charge:
Dr.
Jamuna
Rajeshwaran)
The research focus of this laboratory is music cognition and
neuromusicology from basic science to clinical application.
This is the first laboratory in India which aims at scientific
investigations into basic cognition and neural correlates of
musicperceptionandcognitionaswellasapplicationofmusic
inclinicalconditions.
(a) Perception & Identification of Ragas of Indian Classical
Music: An Exploratory electrophysiological study
(Fundingagency-DepartmentofScienceandTechnology,
FastTrackSchemeforYoungScientist)
Annual Report
(b)
2013-14
Electrophysiological changes and autonomic response
variationstohappyandsademotioninducedviamusic-
Fundingagency-DepartmentofScienceandTechnology
(Cognitivescienceinitiative)
A double blind randomized controlled group study using
ragasofNorthIndianclassicalinstrumentalmusic(NICM)is
beingcarriedoutonpatientssubjectedtoauniformtechnique
of anaesthesia during spinal surgery. The effect of NICM
on stress level assessed using subjective reporting methods
and physiological measures such as cortisol level, heart rate
variability,bloodpressure,aswellasdosageofsedativedrugs
anddepthofanesthesiainpatientsundergoingspinalsurgeryis
beingexamined(NIMHANSintramuralresearchgrant).
THE VIRTUAL DEPARTMENT OF CLINICAL
NEUROSCIENCES
The Virtual Department of Clinical Neurosciences has been
created to foster research temperament amongst medical
graduates with brilliant academic records. The long-term
objectiveofcreationofthedisciplineofClinicalneurosciences
istoboostcapacityatthenationallevelintheemergingfieldof
TranslationalMedicine,specificallyasitappliestoNeuroscience.
TheInstituteenvisagesthatthenewlyset-updepartmentwould
succeed in bringing out clinician-neuroscientists, who are
equallyadeptinbothclinicalandresearchaspects,unlikethe
dichotomythatseemstoexistatpresent.Thisnewenterprise,
therefore expects to bridge the wide gap that exists between
the“benchandthebed-side”,therebyleadingtotranslational
researchthatwillhavemoredirectclinicalapplications.
TheDepartmenthasthreeadjunctfacultymembers:Prof.Vani
Santosh (HOD), Dr. John P. John and Dr. Ravi Yadav. The
Department currently has 23 PhD scholars who are selected
and provided financial support under the Indian Council of
Medical(ICMR)TalentSearchScheme(TSS).Fivecandidates
whohavecompletedMBBSwithbrilliantacademicrecordsare
selectedeachyearonthebasisofacompetitivenational-level
entranceexaminationandpersonalinterview.
During the year under review, interactive workshops were
conducted for various groups – students, parents, teachers,
elderly,generalpublic,mentalhealthprofessionalsandmedical
professionals—on topics related to mental health promotion
and prevention. Mental health education programmes were
organised for Anganwadi children, adolescent girls and
teachers of a few government schools, and young mothers in
Primary Health Centre. The centre has initiated three new
clinicsnamely–TraumaRecoveryClinic(TRC),Awakeclinic
andSHUT(ServiceforHealthyUseofTechnology)clinic.
TRCprovidesbriefpsychologicalinterventionstoadolescents
(>16yearsofage)andadultsurvivorsoftraumathroughoneto-one and /or group counseling and psychotherapy formats,
aswellassocialinterventionstoalleviatesymptomsandpave
the way for holistic healing and recovery. Awake clinic offers
counseling and support to address psychological problems,
particularlyabuseandviolence.SHUTclinicprovidesscreening
forproblematicusageoftechnologyandconductsawareness
andskillbuildingworkshop/trainingworkshopforcounselors
at the Centre as well as in the community (school, colleges,
corporateetc).
PositivePsychologyTeamandNIMHANSCentreforWellBeing
organizedaConferencetitled‘YOUTH-PALS:YouthProAction
Labs’ - Youth Conference with a Difference on 9 December
2013. About 250 participants from more than 25 colleges
and other organizations from different parts (States) of India
participatedintheconference.Conferenceincludedsessionson
mentalhealthpromotionby/foryouth,peersupportforsuicide
prevention, a theatre play on emotion regulation, a song for
road safety, screening of short movies on mental health, and
grouplevelactionlabsforideagenerationandactionplanning
underYouth-PROcorethemes.
Duringtheyear2013-14,NCWBconducted18workshopsand
other educational events (9 at NIMHANS and 9 outside the
Institute),andthefacultyassociatedwiththeCentredeveloped
15 IEC leaflets on mental health related topics. The details of
the workshop and other events are given under each faculty
separately.
NIMHANS CENTRE FOR WELL BEING
CENTRE FOR PUBLIC HEALTH
NIMHANSCentreforWellBeing,anurbancommunitycentre,aims
atworkingonpreventiveandpromotiveaspectsofmentalhealth.
The centre offers clinical services and organizes various training
andoutreachprograms.Theclinicalservicesincludepsychological
interventionsandpsychiatrichelpforminormentalhealthissues.
The Centre for Public Health (CPH) has been established to
providestronginputsforstrengtheningpublichealthresponse
to Mental, Neurological, and Substance Use Disorders
(MNSUDs), injuries and other non-communicable diseases.
Themainareasofworkincludehumanresourcedevelopment,
Annual Report
strengthening public health research, policies and providing
inputsforprogrammesandadvocacy.
Oneofthekeyactivitiesundertakenin2012-13isthedevelopment
ofapublichealthobservatoryinKolardistrict(Government of
Karnataka circular ref: N.HFW30CGE2013 dated 30/1/2013)
to field test public health approaches and strategies for
strengthening response to MNSUDs, injuries and other noncommunicable diseases. A baseline assessment of health
and human resources for mental health, health management
information systems, mental health education and health care
systems for management of MNSUDs was conducted in Kolar
by the CPH team. Training, system development and health
promotion initiatives are being developed to integrate mental
health components into various health programmes. Further,
theKarnatakacomponentoftheNationalMentalHealthsurvey
isbeingcurrentlyundertakeninKolardistrict.
Toincreasethepublichealthcompetenciesofmedicalofficers,
atwo-year‘MastersinPublicHealth’(MPH)wasinitiatedwith
five seats from the academic year 2013-14. The MPH course
isdeliveredinaseriesofconcurrentmodulescoveringgeneral
publichealthconceptsandcorecompetenciesinthefirstyear,
followed by focused training on MNSUDs and injuries in the
secondyear.Attheendofthecourse,thecapacitytomanage
MNSUDsandinjuriesfromapublichealthperspectivewillbe
strengthened,thusleadingtoincreasingavailabilityoftrained
manpowerinduecourseoftime.
CENTRAL ANIMAL RESEARCH FACILITY
TheCentralAnimalResearchFacility(CARF)wasstartedinthe
year 1979 for pursuing and conducting research and training
inneurobiologicalsciences.AtCARFadequatecareistakento
follow rules and regulations, and humane care of laboratory
animals, as proposed by the Ministry of Social Justice and
Empowerment, Government of India, the Committee for the
PurposeofControlandSupervisionofExperimentsonAnimals
andtheBreedingofandExperimentsonAnimals(Controland
Supervision)Rules1998and2001.
2013-14
renewalprojects)wereplacedbeforetheIAECforconsideration
to conduct research using animals. Apart from timely supply of
requiredage,sexandweightofeachstrainofanimal,necessary
support was provided to several studies. In addition, the CARF
also guided and assisted researchers in designing and planning
of protocols, and in day-to-day care of animals (husbandry).
The CARF maintains good standards in husbandry practices,
uses laboratory animals for research responsibly and is deeply
committedtotheprincipleof3R’s:Reduction,Replacementand
Refinementofuseofanimalforresearch.
Duringtheyear2012-13,theCARFhousedandmaintaineda
totalof75,764animals(mice:24,216;rats:51,041,rabbits:243,
guineapigs:264)
Teaching - Training Programme
CARF was also involved in manpower development activities
including organizing IAEC meetings and conducting training
programmes. A total of 40 students and researchers from
NIMHANS (23), as well as from outside institutes (10 plus 7
privatecandidates),attendedthecourseonCare,Breedingand
Management of Laboratory Animals—out of which 38 were
successfulincompletingthecourse.
BIOMEDICAL ENGINEERING
The growing acquisition of sophisticated medical and
analyticalequipmentforclinicalandbiologicalresearchworks
necessitated the formation of a Biomedical Instrumentation
Division at NIMHANS. Biomedical Engineering Department,
established in 1982, performs the dual function of Clinical
EngineeringandBiomedicalEngineering.
CARF supplied research team with timed pregnant animals,
andneonatalanimalsforpreparationofcelllines.Experiments
onspinalcordallograft,studiesonElectroConvulsiveTherapy
(ECT), behavior studies, specialized enrichment experiments
werecarriedout,andassistanceforexperimentalsurgerywere
alsoprovided.
Major functions of the Department include: designing
and development of hardware and software instruments
to support research and clinical programmes; designing
biosensorsandbiomedicalinstrumentationsystemstodetect,
record and analyze physiological functions; repairing and
servicing of medical and analytical instruments, electrical,
mechanical and electromechanical instruments, computer
software and hardware—and their preventive maintenance;
offering consultation for research and clinical specialties and
recommending solutions to instrumentation and electrical
safety problems. The department carried out inspection of
all equipment for condemnation, storage and disposing (of
unserviceableitems).
Duringtheyear,theInstitutionalAnimalEthicsCommittee(IAEC)
metfourtimesandatotalof47researchprojects(28newand19
The department was associated with academic section for
carrying out activities related to computerized evaluation of
Annual Report
2013-14
entranceexaminationforadmissionsoffreshstudentsforthe
year2013-14.
A crash course on Bioinstrumentation and Computer was
conducted (as part of the DCNT Course) for the students of
DepartmentofNeurologyandBasicsofBiomedicalEngineering
for B.Sc. Anesthesia Technology students. A course on
Introduction to Computers was conducted for B.Sc. Nursing
students.In-planttrainingwasprovidedforBiomedicalstudents
fromvariousotherinstitutions.Projectswereofferedforstudents
ofengineeringcollegesaspartoftheirfinalyearcurriculum.
the year under review, the major focus was on accelerating
online access to the latest medical and health information
resourcesinthefieldofmentalhealthandneurosciences.The
process of providing off campus access to e-resources of the
library to NIMHANS was initiated this year. External users
fromdifferentinstitutionsinthecountrycontinuedtousethe
libraryresourcesattheinstitute.
ENGINEERING
Library resources use statistics for the year 2013-14 were as
follows: 4,602 books and journals circulated; 11,923 (pages)
photocopies made; and 155 availed literature search service.
The number of internal and external users of the library was
13,582and6804respectively.
The Engineering Department caters for the maintenance of
hospitalinfrastructure,administrativebuilding,staffquarters,
roads, machinery and equipment like air-conditioners, lifts,
generators,etc.Theactivitiesarecoveredunderplanandnonplanheadofaccount.
Networking: All the subscribed library e-resources and
e-databases, including full-text databases, are available for
accessfrommorethan1,500LANaccesspointsontheCampus
Network.Thisisahighbandwidth(1GB)networkfromtheNIC
NationalKnowledgeNetwork.
Someofthemajorworkscompletedintheyear2013-14include:
Constructionofthirdfloorintheexistingladieshostel(Nurses
Hostel) at BRC campus; conservation of old OPD (Children’s
Pavilion)/heritage building; construction of chamber for the
President, NIMHANS Society above Library and Information
Centre; construction of third floor above the existing Cauvery
hostel at BRC campus; construction of additional sump tank
adjacenttoKabiniHostelbuilding;constructionofahallinthe
firstfloorofNCWBatBTMlayout;supplying,installing,testing
andcommissioningof250KVADGsetatSakalawaracampus;
constructionofbuildingforinpatienttreatmentforwomenwith
substanceuse(groundfloorandfirstfloor);providingwireless
smokedetectorsandalarmsystemtoNBRCandGovindaswamy
Centre; providing solid waste converter near at laundry;
providingtrenchlessinterlinkingofwatersupplysystem.
Cyber Hall:CyberHallfacilityisapopularserviceamongthe
userswhereinuserscometothelibraryandhaveaccesstoall
the e-resources of the library. The facility has been upgraded
withlatestcomputersystemsonhighbandwidthnetworkand
applications.
Other important works which are under progress include:
ConstructionofadolescentsinpatientwardsfortheDepartment
ofChildandAdolescentPsychiatry;constructionofsecondand
thirdfloorabovethebuildingforinpatienttreatmentforwomen
withsubstanceuse;andconstructionofcompoundwallaround
theproposednortherncampusatKyalasanahalli,Bangalore.
LIBRARY AND INFORMATION CENTRE
TheLibrary&InformationCentrecontinueditseffortstomake
more and more services of the library to be computer-based
andachievedgreatsuccesswiththeinaugurationofOPACand
circulation services by the Director on 3 March 2014. During
Library Automation:Theautomationofcirculationservices
oftheLibrarywasinauguratedbytheDirectoron3March2014.
Withthis,thecompleteprocessofissueandreturnofbookswill
becarriedoutthroughBarcodedMembershipCards.Thesystem
sendsautomaticemailstotheuserontheissuanceofabook,
andremindstheuserwhenabookisdueforreturning.During
theyear,thealreadyexistingwebOPAC(OnlinePublicAccess
Catalogue)ofthelibraryalsogotupgradedforenhancedonline
accessthroughLIBSOFT.TheexistingCirculationCounterwas
redesigned,andtherenovatedcounterwasinauguratedbythe
Directoronthesameday.
e-journals subscribed: Amajorreviewofthequalityandthe
number of e-resources being subscribed to by the library was
carriedoutduringtheyear.Electronicjournals(2362)andprint
journals(49)subscribedintheyearincludeElsevierHealth(6);
ElsevierHealthClinics(8);Karger(22);Nature(14);Ovid(26);
ProQuest (1253); EBSCO: Psychology & Behavioral Science
Collection(557);EBSCO:Psycarticles(104);PsychiatryOnline
(4); Sage + Online Free (10); Science Direct (131); Society
Journals (29); Springer (10); Taylor & Francis (149); Wiley
(39). Other library online bibliographic databases subscribed
include Ebsco:MedlineCompleteandPsycInfo.
Annual Report
2013-14
Atotalof202newbooksand110newgiftbooksanddissertations
wereaddedtothecollection,duringtheyear.
Studies,checkingnameboards/signboards,rubberstamps,etc.
weretheotheractivitiescarriedoutonaregularbasis.
Dr.MJayaram,SeniorProfessor,Dept.ofSpeechPathologyand
Audiology was nominated as Officer-in-Charge of the Library
witheffectfrom1August2013onthesuperannuationofDr.HS
Siddamallaiah,PrincipalLibraryandInformationOfficer.The
new Library Advisory Committee was constituted, with effect
from18October2013,withProf.GSUmamaheswaraRaoas
Chairperson
Hindi Cell
PUBLICATION DEPARTMENT
TheDepartmentofPublicationcontinuedtoprovideanefficient
systemfordisseminatingknowledgeaboutmentalhealthand
neurosciences through various specialised services and other
importantactivitiesduringthereviewperiod.
The department undertook copy editing and proof-reading—
and coordinating the printing—of the following publications:
Directory of Mental Health Care Centres in South India;
Effective Caregiving in Dementia; Handbook of Psychiatric
RehabilitationServices;ECTAdministrationManual—Revised
Edition.Copyediting/proofreadingofleaflets,flyers,prospectus
andothervitalinformationmaterialswerecarriedout.Printing
andpublishingofConvocationmaterialswerealsohandledby
thedepartment.
Institute Reports: The Annual Report 2012-13 (both
in English and Hindi) was successfully brought out by the
department, under the aegis of the Co-ordinating Committee
formedbytheDirector.TheInstituteActivityReports—which
presentcomprehensiveinformationoftheInstitute’sactivities,
developments and achievements—were also generated for
BoardofManagementandAcademicCouncilMeetingsheldin
theperiodunderreview.
Language Classes: The Department organised Kannada
classesinassociationwiththeKannadaandCultureDepartment,
Government of Karnataka, for the benefit of non-Kannada
speaking faculty and staff. English classes for BSc Nursing (I
year)studentswerealsocoordinatedbytheDepartment.
Other Activities:Certificatesforconsentforms(tobepresented
to the Ethics Committee) of various research activities were
issued after comparing/checking the veracity and correctness
ofthetranslatedformswiththeoriginalversion(s).Publications
storage and inventory management, translation of notices and
vital administrative communications into regional language,
coordinatingtranslationworkswiththeInstituteofTranslation
Hindi Cell, functioning under the Publication Department,
undertook various activities under the guidance of the
Department of Official Language, Union Ministry of Health
andFamilyWelfare,GovernmentofIndiawithaviewtoensure
compliancewiththeOfficialLanguageImplementationpolicies
andConstitutionalprovisions,andtopromoteprogressiveuse
ofHindifortheofficialpurposes.
Translation Activities: Consent forms for research/
academic activities, tender notifications, and other important
correspondencesweretranslatedintoHindi,onaregularbasis.
Correspondence in Hindi: LetterstoofficesoftheCentral
Government,locatedinregions‘A’,‘B’and‘C’,asclassifiedby
theMinistry,wereissuedinHinditotheextentpossible.Official
documentspertainingtotheMinistrywerebeingsignedbythe
DirectorandRegistrarinHindi.
All name boards and sign boards of the Institute have been
displayed in trilingual format (English, Hindi and Kannada).
Thought for the Day was written in Hindi and English, every
day,onthedisplayboardsatAshwiniBlockandNeuroCentre
for the benefit of employees/ hospital staff and to facilitate
learningofHindi.
Hindi Training: Hindicourse/classes(Probodh,Praveenand
Pragya), under the Hindi Teaching Scheme, were conducted
regularly to impart training to the employees of the Institute
whodonotpossessworkingknowledgeofHindi.HindiTyping
and Hindi Stenography training was also provided under the
scheme.
Hindi Week Celebrations: Hindi Week was celebrated at
NIMHANSinthemonthofNovember.Athree-dayworkshopon
Unicode,byShri.EshwarChandraMishra,AssistantDirector,
Central Translation Bureau, and various other competitions
suchasessaywriting,debate,notinganddrafting,singing,etc.
wereorganisedaspartoftheHindiWeekcelebrations.
Valedictory function was held on 28 December 2013. Smt.
Janaki Nair, Joint Director, Central Translation Bureau,
Kendriya Sadan, Bangalore was the chief guest. Cash awards
and certificates to those who have passed Hindi exams with
distinction were given away by the Director/Vice-Chancellor
and the chief guest of the function. Prizes were also handed
Annual Report
2013-14
overtothewinnersofvariouscompetitions,heldaspartofthe
HindiWeekCelebrationsinNovember.
carom, chess and basketball. It also has men and women
Gymnasium wings, library, crèche, locker rooms, utility/yoga
room,amphitheater,andcommunityhall.
The Basketball Court was renovated during this reporting
period.ItwasinauguratedbythePresidentandVicePresident,
NIMHANS Gymkhana on 9 July 2013.On the same day, free
notebooksweredistributedto96childrenandmeritcashprizes
wereawardedto115children(from1ststandardtoPGcourses)
oftheNIMHANSstaff.
Valedictory function of Hindi Week Celebrations
NIMHANS GYMKHANA
TheNIMHANSGymkhanaisarecreationalandsportsfacility
provided exclusively to the staff, students and their families.
The Director/Vice-Chancellor, NIMHANS is the President of
Gymkhana and Registrar, NIMHANS is the Vice-President.
All the activities are monitored by the Executive Committee
headed by a nominated Chairman. The Executive Committee
has representations from all categories of staff, apart from
student representatives. Situated on Byrasandra campus of
NIMHANS,Gymkhanahasbeenbuiltinanareaof2,535sqm
withaplinthareaof10,320sqm.
TheGymkhanahasthestate-of-the-artfacilitiesandequipment
for sports, physical activities and recreation. It has multiple
facilitiesforvariousindoorgameslikebadminton,tabletennis,
SPICMACAY-NIMHANSchapterinassociationwithNIMHANS
Gymkhana organised a santoor recital by Padma Vibhushan
PanditShivkumarSharmaatNIMHANSConventionCentreon
22July2013.
Indoor/outdoorsportsandculturalcompetitionswereheldfor
thestaffandstudentsofNIMHANS,aspartoftheInstituteDay
celebrations.Theeventsevokedoverwhelmingresponseandsaw
participationfrom1200participantsfromstaffandstudents.
Various sports and games were conducted for children of the
staff, on the occasion of Children’s Day. About 210 children
participatedintheevents.Cashprizesweredistributedtothe
winnersonChildren’sDay(14November2013).
Aspecialscientifictalkon“CleanandGreenCampus”andvideo
demonstration of scientific disposal of waste on the campus
washeldon7December2013,atGymkhana.Ontheoccasion,
Gymkhanaconductedadrawingcompetitionforchildrenand
cashprizeswereawardedtothewinners.
Annual Report
2013-14
Annual Report
2013-14
Research Activities
Biophysics
1.
Purinergic signaling in astrocytes: Implications
in pathophysiology of epilepsy. Investigator: Dr.
Preeti Joshi (Funding by DBT)
Traditionallytheprimaryfocusofresearchonpathophysiologyof
epilepsy has been neuron centric. Recent studies suggest a direct
contribution of astrocytes to generation of epileptic discharge.
Studies on experimental model of focal epilepsy suggest that
neurons engage astrocytes in a recurrent excitatory loop that
promotestheinitiationandsustenanceoftheictaldischarge.These
studiesestablishthatastrocytesarecrucialpartnersinepileptiform
activity but the mechanisms responsible for spread of epileptic
dischargeandepileptogenesishavenotbeenaddressed.Purinergic
receptors play a pivotal role in neuron-astrocyte cross talk. The
changesinglialfunctionduringdifferentphasesofepileptogenesis
are being investigated. In an animal model of temporal lobe
epilepsy, significant morphological and functional changes in
astrocytes immediately after the onset of first seizure have been
observed.Astrocytesshowsignificantmorphologicalchangessuch
ashypertrophyandelongationofprocesses.Expressionofseveral
metabotropic purinergic receptors in astrocytes is considerably
upregulatedwithin1-2hoursofstatusepilepticus.Astrocyteselicit
hyperCa2+activityindependentofneuronalactivity.Experimentson
neuron-astrocytecrosstalkshowthatactivationofP2Y2receptors
inastrocytessignificantlyenhancesthehyperactivityinneurons.
ApoEgenemutationshavebeenassociatedwithdementia.ApoE4
allele is considered a risk factor for Alzheimer’s disease (AD)
butthecellularmechanismsforthisassociationarenotknown.
Deregulation of intracellular signaling events is a common
event in disease biology. Abnormalities in Ca2+ regulation in
the peripheral cells including lymphoblasts, lymphocytes and
fibroblasts have been reported. The role of naturally occurring
apoE3/3alleleinCa2+dysregulationinaperipheralmodelofa
lymphoblastoid cell line and in derived cell lines, which differ
onlyintheApoEgenotype,isbeinginvestigated.
TheCa2+ signalingprofileoflymphoblastoidcelllines(LCL)isolated
fromAlzheimer’spatientswerestudied.Thebasal[Ca2+]ilevelswere
determined and the signals evoked by various neurotransmitters
and other activators of intracellular Ca2+ release were measured.
Blindexperimentswereperformedondifferentcelllinestoavoid
thebias.SignificantdifferencesinCa2+ signalingincelllinesderived
fromADpatientsandcontrolsubjectswereobserved.
Measurement of Ca2+ signals in lymphoblastoid cells. Fluorescence intensity
Ratio (340/380 nm) images of fura-2 loaded before and after stimulation with
PMA and a typical [Ca2+]i kinetics in a single cell.
3.
Morphological changes in live hippocampal slices isolated from rats in control
and status epilepticus condition for 2 hrs. Scale = 20 µm.
2.
Calcium signaling, mitochondrial and ER
function in lymphoblastoid cells with different
ApoE genotypes. Investigator: Dr. Preeti Joshi
(Funding by DBT)
Mechanisms of action of neuropathic pain targets:
Electrophysiological and calcium imaging studies
in spinal cord neurons. Investigators: Dr. Preeti
Joshi, Yu-Wen Li, Bristol-Myers Squibb Company,
Wallingford, CT, USA, Reeba Vikramadithyan,
Biocon Bristol-Myers Squibb R&D Center, Syngene
International Ltd., Bangalore, Sreenivasulu Naidu
Annual Report
Pattipati, Biocon Bristol-Myers Squibb R&D
Center, Syngene International Ltd., Bangalore
(Funding by Bristol-Myers Squibb Company)
Followingnerveinjury,primarysensoryneuronsinthedorsal
root ganglion and secondary sensory neurons in the spinal
cord dorsal horn exhibit a variety of electrophysiological
abnormalities, including increased baseline sensitivity and/or
hyper-excitability,whichcanleadtoabnormalburstinactivity
and central sensitization that underlies pain. However, the
molecularbasisforthesechangeshasnotbeenfullyunderstood.
Understandingthemechanismsofactionofknowndrugsand
noveltargetsinneuropathicpainmodelsiscriticalindesigning
moleculeswithimprovedefficacyandreducedliabilitiesinclinic
andinsupportingclinicaldevelopmentofthesemolecules.The
investigatorsarecharacterizingthespinaldorsalhornneuronal
signaling in chronic constriction injury (CCI) and diabetic
peripheral neuropathic pain (DPNP) rat models of pain in
termsofcalciumsignals,andtheeffectsofsomeknowndrugs
usedforneuropathicpainarebeinginvestigatedusingrealtime
Ca2+imagingandelectrophysiologyinlivespinalcordslices.
4.
Role of mitochondria in selective degeneration of
motor neurons in amyotrophic lateral sclerosis.
Investigators: Dr. Preeti Joshi, Dr. NB Joshi, Dr.
A Nalini
2013-14
targets for various neurological disorders including ischemia,
epilepsy, Parkinson’s and Alzheimer’s diseases. The known
iGluA modulators, cyclothiazide (CTZ), IDRA-21, and other
benzothiadiazide derivatives (ALTZ, HCTZ, and CLTZ) bind
to the ligand-binding domain of flip-form of iGluA2 at the
dimer interface, thereby increasing steady-state activation by
reducingdesensitization.
To discover new modulator compounds, the investigators
performedvirtualscreeningfortheligandbindingdomain(LBD)
of iGluA2 against NCI Diversity Set III library containing 1597
compounds,andsubsequentlyperformedbinding-energyanalysis
forselectedcompounds.ThecrystalstructureofratiGluA2S1S2J
(PDB ID: 3IJO) was used for docking studies. From this study,
four compounds were obtained: (1) 10-2 (methoxyethyl)-3phenylbenzo[g]pteridine-2,4-dione, (2) 2-benzo[e]benzotriazol2-yl-aniline, (3) 9-nitro-6H-indolo-(2,3,-b) quinoxaline, and (4)
1-hydroxy-n-(3-nitrophenyl)-2-napthamide.Thebindingmodeof
thesefourcompoundsisverysimilartothatofabovementioned
established modulators: two molecules of each compound
independently bind to the protein symmetrically at the dimer
interface;occupythesubsitesB,C,B’andC’;potentiallyinteract
withSer518andSer775.Bindingenergyanalysisshowsthatallthe
fourhitsarecomparabletothedrugmolecule,CTZ,andhence,
theinvestigatorsproposethatthediscoveredhitsmaybepotential
molecules to develop new chemical libraries for modulating the
flipformofiGluA2function.
Selective and progressive loss of motor neurons in the
spinal cord, brainstem, and motor cortex is hallmark of the
Amyotrophiclateralsclerosis(ALS).Thoughthemotorneuron
degeneration in ALS is considered a multifactorial process,
the glutamate induced toxicity is a major contributory factor
in the selective injury to motor neurons. The investigators
observed that cerebrospinal fluid from ALS patients causes
mitochondrial dysfunction, selectively, in motor neurons (in
culture)throughglutamatereceptors.AdditionofALSCSFto
mixed spinal neuron culture caused fusion of mitochondria
clustering towards the plasma membrane. The mitochondrial
functionalparameterssuchasmembranepotential,Ca2+levels
werealsosignificantlyaltered.
5.
Identification of novel modulators for ionotropic
glutamate receptor, iGluA2 by in-silico screening.
Investigator: Dr. B Padmanabhan
Ionotropic glutamate receptors (iGluAs, IUPHAR
nomenclature) are the major excitatory amino acid
neurotransmitter receptors in the mammalian central
nervous system (CNS). iGluAs are potential therapeutic drug
A representative diagram for superposition of the compound #3 onto #4. The
ligands and interacting residues are shown in sticks. The oxygen and nitrogen
atoms are colored in red and blue, respectively.
6.
Analysis of dimerization of BTB-IVR domains of
Keap1 and its interaction with Cul3, by molecular
modeling. Investigator: Dr. B Padmanabhan
Annual Report
2013-14
Oxidative damage has been associated with various
neurodegenerative diseases including Parkinson’s disease,
amyotrophiclateralsclerosis(ALS),andAlzheimer’sdisease,as
well as non-neurodegenerative conditions such as cancer and
heartdisease.TheKeap1-Nrf2systemplaysacentralroleinthe
protectionofcellsagainstoxidativeandxenobioticstress.TheNrf2
transcription function and its degradation by the proteasomal
pathway(Keap1-Nrf2-Cul3-Roc1complex)areregulatedbythe
cytoplasmic repressor protein, Keap1 which possesses BTB,
BACK(IVRregion)andKelchdomains.TheBTB-BACKdomains
areimportantforKeap1homo-dimerizationaswellastointeract
withCullin-3forNrf2degradation.Thecrystalstructureofthe
Keap1-Kelchdomainisknown;however,thatoftheBTB-BACK
domains are not yet determined. The investigators present,
throughmolecularmodelingstudies,theanalysisofKeap1-BTB
dimerization,andofBTB-BACKdomainsroleincomplexwith
Cul3. The electrostatic charge distribution at the BTB dimer
interface of Keap1 is significantly different from other known
BTBcontainingproteinstructures.Anotherintriguingfeatureis
alsoobservedthatthenon-conservedresiduesattheBTB-BACKCul3 interface region may play critical role for differentiating
Cul3recognitionbyKeap1fromotheradaptorproteinsfortheir
specificsubstratesproteasomaldegradation.
neurodegeneration, autoimmune/inflammatory diseases,
metabolic diseases and viral infections. Hence, the epigenetic
targetsareofgreatimportancetodiscovernewdrugmolecules
for various major diseases. While drugs targeting histone
deacetylase (HDAC) and DNA methyltrasferase (DNMT) are
clinically approved recently, drug discovery targeting other
epigenetic markers are in the pipeline. One of the epigenetic
‘reader’proteins,bromodomaincontainingproteinsrecognizes
acetylated-lysinehistones(H3andH4)andinvolveinregulating
geneexpressionandgenesilencing.
The BET family nuclear proteins have a unique architecture
with two tandem bromodomains (BD1 and BD2) and a
conserved extra-terminal domain. The BRD2 protein, which
belongs to the BET family, recognizes mono-acetylated
histone H4 at Lys12 (H4K12ac) and di-acetylated histone
H4 at Lys5 and Lys12 (H4K5ac/H4K12ac) through N- and
C-terminal bromodomains, respectively. The BRD2 protein
are reported to possess potential role in the pathogenesis
of cancer, defects in embryonic stem cell differentiation,
seizures and neurodegenerative disorders (NDD) such as
Parkinson’s disease. The project aims to obtain inhibitor
moleculesforBRD2BD1andBD2bromodomainsbyrational
drug discovery approach. The work involves multifaceted
approachesofmolecularbiology,proteinbiochemistry,protein
crystallography,andcomputationalbiology.Theinvestigators
recentlycloned,expressedandpurifiedtheBRD2BD2protein
tohigh-endpurity.In-silicoscreeningusingNCI-DiversitySet
III library gave a set of compounds with significant binding
energyvalues(Figure).
A cartoon ribbon diagram of the BTB-BACK domains in complex with Cul3
(violet) (PDB Id: 4AP2), and labeled only the interacting secondary structure
elements.
7.
Drug discovery of potent inhibitors for epigenetic
marker, BRD2 bromodomains by rational
structure based approach. Investigator: Dr. B
Padmanabhan (Funding by DBT)
Aberrations in epigenetic mechanisms results in abnormal
cellularfunctions,andcanleadtothedevelopmentofcancer,
The compound BD1-INI#1 nicely binds into the acetylated-histone binding
pocket of human BRD2-BD1.
Annual Report
8.
Structure-function analysis of HDAC domain of
human SIRT1 and discovery of pharmaceutically
acceptable
SIRT1
inhibitors
by
rational
drug design approach. Investigator: Dr. B
Padmanabhan (Funding by DST)
Sirtuins belongs to the NAD+-dependent class III histone
deacetylases (HDACs) family, distinct from ‘classical’ class I/
II/IV HDACs. Sirtuins are known to protect against stress
associated with neurodegeneration, including oxidative
damageandproteinmisfolding.TherecentliteratureonSIRT1
and SIRT2 suggest that these targets are emerging targets
in neurodegeneration. SIRT1 is ubiquitously expressed in
all tissues including the brain. SIRT1 is known as a nuclear
protein, which is predominantly expressed in neurons. The
activation of SIRT1 by a drug molecule, in the brain, may be
usefulfortheNDtreatment.Theprincipalaimofthisproposal
istodeterminethecrystalstructureofHDACdomainofSIRT1,
and to rationally design lead selective small-molecule SIRT1
activators for treating ND. The investigators have cloned,
expressed the HDAC domain of human SIRT1 and purified it
byNi-NTAaffinitycolumn(Figure1).Theproteinproduction
optimization and in-silico screening to obtain modulators are
inprogress.
9.
Drug discovery of novel inhibitors for human
Superoxide Dismutase I (hSOD1). Investigator:
Dr. B Padmanabhan, Dr. Richard Strange,
Liverpool University, UK
MostcasesofAmyotrophiclateralsclerosis(ALS),aresporadic
(sALS); however, approximately 10% are familial (fALS). The
fALS disorder is primarily a heterozygous genetic condition.
Morethan140pointmutationslinkedtofALShavebeenfound
in throughout human SOD1-gene. The cumulative lifetime
risk for MND is approximately 1 in 1000. Patients succumb
tothisdiseasewithin3-5yearsafterthediagnosis.Becauseof
late diagnosis, life expectancy of patients is usually low. The
currentlyapproveddrugtilldateforthetreatmentofMNDis
Riluzole,butitseffectivenessisless,providinga9%gaininthe
chanceofsurvivalforoneyearafterinitiationoftreatment.
Superoxide dismutase 1 (SOD1) is a ubiquitous homodimeric
metalloenzyme. The aggregation or oligomerization which is
usuallyfoundinSOD1mutantsleadstopathogenesis.Hence,
blocking aggregation or oligomerization is a better strategy
to cure ALS/MND disease. The objective of this project is to
discover and develop compounds by rational structure-based
drugdiscoverymethod,toarrestaggregationofSOD1,thereby
2013-14
preventingorslowingdownALS/MNDdisease.Inthisaspect,
the investigators have recently expressed human SOD1 in
E.coli, and purified to homogeneity with more than 95 %
purity. They have obtained the hSOD1 protein crystals from
proteincrystallizationscreening(Figure1).In-silicoscreening
and docking studies and protein crystallography work are in
progress.
A
B
(A) SDS-PAGE of hSOD1 before and after cleavage of His-tag. (B) A representative
image of hSOD1 crystals grown in PEG6000 as major precipitant.
10.
Preclinical studies on brain tumours: combination
of adjuvants with different mechanisms of
radiosensitization. Investigator: Dr. Vijay Kumar
Kalia, Dr. Vani Santosh (Funding by DBT)
Primary cells of high grade gliomas obtained from tumour
biopsies were cultured in EMEM + 20% FBS. These cultures
did not show the typical lag phase observed in cultures from
established cell lines. Ultrastructural studies (TEM) showed
that the untreated glioma cells had ounded nucleus with a
prominentnucleolus,plasmamembranehadlotsofmicrovilli
like processes. Temozolomide (TMZ, 10 and 20µM, 4hrs)
treatedcellsshowednucleardamage(indentednuclei,nuclear
fragments and smooth plasma membrane. Exponentially
growing cells as monolayer were fixed in Methanol-Acetic
Acid and stained with 0.002% Acridine Orange. These cell
linesshowedvariablefrequenciesofdamagedcells(apoptosis,
andmicronuclei),evenwithoutanycytotoxictreatments.The
damagewasincreasedafterTMZ(≤10M)andirradiation(1-2
GyCo60γrays).Combinationof2-Deoxy-D-Glucose(0.5mM)
further increased damage in all the tumors. Combinations of
thesedrugsatclinicallyfeasible,lowconcentrations±radiation
could,therefore,improvetreatmentofmalignantgliomas.
ThefocusofthestudyareEffectsofcombiningAllTransRetinoic
Acid(RA,Retinal)withTemozolomidetreatmentonradiation
damageinU373MG,anestablishedmalignanthumanglioma
cellline,EffectsofcombiningeitheraretinoidorLonidamine
withTemozolomidetreatmentonradiationdamageinhuman
Annual Report
2013-14
brain tumour cells of different origins, Elucidate the possible
mechanism(s)ofradiosensitization;andTheeffectsoftumour
biologyonthecellularresponsetothesetreatments.
11.
P2Y receptor mediated signaling in rat
hippocampus. Ms. Biji Jose (CSIR Fellow). Guide:
Dr. Preeti Joshi
12.
Interaction of P2Y receptor and TRPV1 channel in
dorsal root ganglion (DRG) neurons. Mr. Mahendra
Singh (UGC Fellow). Guide: Dr. Preeti Joshi
13.
Involvement of astrocytes in epilepsy.Mr. Bhanu
Prakash Tewari (CSIR Fellow). Guide: Dr. Preeti
Joshi
14.
Neuron-astrocyte interaction in relation to
excitotoxicity in spinal neurons. Ms. Siksha
Sharan (DST INSPIRE Fellow). Guides: Dr. Preeti
Joshi, Dr. A Nalini
15.
Role of endoplasmic reticulum and mitochondria
in calcium signaling in spinal neurons. Mr. Ajay
Irmale, Guide: Dr. Preeti Joshi
16.
Protein production of mouse KEAP1-DC and
screening of its designed inhibitors and crystal
structure analysis of hypothetical protein
TM0360. Mr. Prashant Deshmukh. Guide: Dr. B
Padmanabhan
17.
Glutamatergic and purinergic signaling in spinal
sensory neurons. Mr. Yuvraj Joshi. Guide: Dr.
Preeti Joshi
3.
Migration, poverty and access to health care:
A study on people’s access to health systems’
response. Investigators: Dr. P Marimuthu, Dr.
DK Subbakrishna, Dr. K Sekar, Dr. Manoj Kr.
Sharma, Dr. RT Venkatesh, Deputy Director
(State Surveillance Unit), Office of the Director
General of Health Services, Government of
Karnataka (Funding by ICMR)
The investigators have involved diverse and inclusive
representationofstakeholders/participantsfrommigrantand
host communities including community-based organizations
and personnel from health, political and other, social
developmentsectorsoflocaladministration,non-governmental
agencies in decision-making. The intervention components
willbeimplementedinafewurbanpocketsidentifiedasmost
vulnerableandsomeotherpocketswillbeselectedandstudied
ascontrolgroups.
Beneficiaries will be informed by the community leaders,
CBO and NGO working in the slum locations. Health
services will be provided to the migrant population by a
team of health service providers, consisting of doctor(s),
nursesandhelpers.Theteamwillvisittheslumsonceinten
days, for providing the general health services, treatment
of minor illness, supply of medicine, referrals, diagnosis,
healtheducationandmentalhealthintervention.Atotalof
10 visits for three and a half months has been proposed.
A research associate and a research assistant will also be
partoftheteamproposedforthehealthcamp.Intervention
programme is completed and the end-line survey is about
tostart.
4.
Development of screening tool for Psychiatry
morbidity. Investigator: Dr. Manoj Kumar
Sharma, Prof. SK Chaturvedi, Dr. P Marimuthu
(Funding by INHANS)
Biostatistics
1.
Structural equations modeling approach to study
latent relations among clinical, immunological
& neuroimaging parameters in schizophrenia.
Investigator: Dr. DK Subbakrishna (Funding by DBT)
5.
Comparison of illness severity scoring systems for
mortality prediction in Neuro intensive care unit.
Investigator: Dr. Sonia Bansal, Dr. Mariamma
Philip
2.
Biostatistical consultancy for conduct of fresh
anthropometric survey of a representative sample
of IAF Aircrew. Investigator: Dr. DK Subbakrishna
(Funding by Institute of Aerospace Medicine)
6.
Generativity in cognitive networks under Cognitive
Science Research Initiative (CSI). Investigators:
Dr. DK Subbakrishna, Dr. Rose Dawn Bharath,
Dr. B Indira Devi (Funding by DBT)
Annual Report
2013-14
correlationsduringmoreattentivetaskofvisualencoding.In
tunewiththerecentstudiesoncognitivereserve,investigators
alsofoundthatnumberofyearsofeducationwasasignificant
factor influencing working memory connectivity. SE had
higherpositivecorrelationtoDLPFCregionandlowernegative
correlation to DMN in comparison with CE during encoding
andretrieval.
1.
Effect of Ayurvedic Coded Drug (Ayush-Manas)
in the management of Manasa Mandata (Mental
retardation). Investigators: Dr. Girimaji SC, Dr.
Srinath S, Dr. Seshadri SP (Funding by CCRAS,
Govt. of India)
ThisisadoubleblindplacebocontrolledclinicaltrialofanAyurvedic
coded drug with one-year prospective follow-up in 6 to 13 yearoldchildrenwithmildtomoderatedegreeofmentalretardation.
In total, 797 were screened, 120 participants were recruited and
followed up. Ninety one participants completed the trial. Data
obtainedwassenttoCCRASforcentralizeddataanalysis.
Seed to voxel based connectivity for PCC seed for encoding and retrieval in
the context of education. CE encoding (a), CE retrieval (b) SE encoding (c), SE
retrieval (d). Red color demonstrating positive correlation with source seed and
blue color demonstrating negative correlation with source seed
Human memory is an enigmatic component of cognition
which many researchers have attempted to comprehend.
Accumulatingstudiesonfunctionalconnectivityseebrainasa
complexdynamicunitwithpositivelyandnegativelycorrelated
networksinperfectcoherenceduringatask.Theinvestigators
aimed to examine coherence of network connectivity during
visual memory encoding and retrieval in the context of
education. School Educated (SE) and College Educated (CE)
healthy volunteers (n = 60) were recruited and assessed for
visual encoding and retrieval. Functional connectivity using
seed to voxel based connectivity analysis of the posterior
cingulatecortex(PCC)wasevaluated.Theinvestigatorsnoticed
thattherewerereciprocaldynamicchangesinbothdorsolateral
prefrontal cortex (DLPFC) region and PCC regions during
working memory encoding and retrieval. In agreement with
the previous studies, there were more positively correlated
regions during retrieval compared to encoding. The default
mode network (DMN) networks showed greater negative
2.
Study of neural development in a human induced
Pluripotent Stem cell (hiPS) model of primary
microcephaly. Investigators: Dr. Satish Girimaji,
Dr. K John Vijay Sagar (Funding by DST)
3.
An exploratory study of Emote Sensor in children
with Autism Spectrum Disorder. Investigators:
Dr. John Vijay Sagar, Dr. TN Sathyaprabha
4.
A study of brain imaging, neuropsychological
profile, genetic markers and eye movements in
first degree relatives of children with Autism
spectrum disorders (ASD). Investigators: Dr.
Srinath S, Dr.Girimaji SC, Dr. Seshadri SP, Dr.
Vijay Sagar KJ, Dr. Ravindranath V, Dr. Kumar
K, Dr. Murthy A, Dr. Prasad C
Eighteen families with 33 first degree relatives of children
diagnosedwithAutismSpectrumDisorderhavebeenrecruited
for the study in the proband group. Of this the whole set of
assessments mentioned above has been completed for nine
families(i.e,19firstdegreerelativesofchildrenwithASD).For
theresttheprocessoftestingisongoing.Inthecontrolgroup,
four families with six individuals have been recruited for the
study.
Annual Report
5.
6.
2013-14
Autism spectrum disorders and epilepsyExploration of a relationship. Investigators:
Dr. Srinath S, Dr. Girimaji SC, Dr. Seshadri SP,
Dr. Vijay Sagar KJ, Dr. Satishchandra P, Dr.
Sinha S, Dr. Hirisave U, Dr. Roopesh BN, Dr.
Shivashankar, Dr. Yamini, Dr. Subbakrishna DK
(Funding by ICMR)
Imaging and biochemical correlates in children
with Autism spectrum disorder with and without
Epilepsy. Investigators: Dr. Vijay Sagar, Dr.
Srinath S, Dr. Seshadri SP, Dr. Vijay Sagar KJ, Dr.
Jain S, Dr. Purushottam M , Dr. Subbakrishna DK
7.
Role of genetics in Autism spectrum disorder
with and without epilepsy. Investigators: Dr.
Girimaji SC, Dr. Srinath S, Dr. Seshadri SP, Dr.
Vijay Sagar KJ, Dr. Jain S, Dr. Purushottam M,
Dr. Subbakrishna DK
8.
A prospective study of the course and outcome
of children and adolescents with attention
deficit hyperactivity disorder in a tertiary care
centre. Ms. Preeti Jacob. Guides: Dr. Srinath S,
Dr.Girimaji SC, Dr. Seshadri SP, Dr.Vijay Sagar
KJ
The objective was to examine the short-term course and
outcome of children with ADHD who received treatment as
usual from the out-patient services of a tertiary care centre.
Sixtythreechildrenwereincludedinthestudyatbaselinewere
diagnosedtohaveADHDasperDSM-IV-TRdiagnosticcriteria.
Thirtyninechildrenwereavailableforthe24thweekfollow-up
assessment and 37 children were present for all assessments
(baseline, 6 weeks, 12 weeks and 24 weeks). There were 54
boysand9girlsinthesamplestudied,and92.1%hadADHDCombined subtype. Psychiatric comorbidity was present in
82.5% of the sample at baseline with Oppositional Defiant
Disorder(ODD)andAnxietydisordersbeingthemostfrequent.
There was a significant relationship between psychiatric
comorbidity and the ADHD-RS scores. The medications
used to treat ADHD were Clonidine, Atomoxetine and
Methylphenidate.Risperidonewasusedinasmallproportion
of subjects to control aggressive and disruptive behaviour.
Combinationmedicationwasusedmorefrequentlyinsubjects
with severe illness and intellectual disabilities. There was no
change in the weight in 8 (12.7%) children, and 12 (30.8%)
lost weight ranging from 1-5 kilograms over 6 months. The
severityofsymptoms,functionalityandqualityoflifeimproved
significantlyover24weekswithtreatmentasusual.Severityof
illnessatbaselineandthepresenceofpsychiatriccomorbidity
especially oppositional defiant disorder predicted short-term
outcome.
9.
Short term outcome of anxiety disorders in
children and adolescents. Ms. Preeti Kandasamy.
Guides: Dr. Girimaji SC, Dr. Srinath S, Dr.
Seshadri SP, Dr. Vijay Sagar KJ
Thestudyaimsatprospectivelystudyingthecourseofanxiety
disorders in children and adolescents overaperiod of six
monthswithemphasisonfollowingoutcomemeasures-levelof
functioningandqualityoflife.Italsoaimsatexaminingfactors
thatmodifytheshort-termcoursesuchassocio-demographic
variables,clinicalvariables-illnesscharacteristics,comorbidity,
etc.andlifeevents.Theothermajorobjectiveofthestudyisto
examinethesubjectiveexperienceofchangeintermsofillness
experience,illnessimpactandtreatmentimpactthroughtheir
narratives. The recruitment process has been done, while the
six-monthfollow-upevaluationisnearingcompletion.
10.
Factors affecting outcome in oppositional defiant
disorders: a 3-month prospective study. Mr.
Raghunandan Mani. Guides: Dr. Vijay Sagar KJ,
Dr. Srinath S, Dr. Girimaji SC, Dr. Seshadri SP
Oppositionaldefiantdisorder(ODD)isaleadingcauseofreferral
foryouthmentalhealthservices;yet,manyuncertaintiesexist
about ODD as it is rarely examined as a distinct psychiatric
disorder. Children’s early individual differences could set
off a chain of transactions between child and environment
that could lead eventually to ODD. Studies of ‘vulnerability
associations’haveshownthatpersonalitytraitscouldbearisk
factor that causes individual to be vulnerable to development
of psychopathology, particularly in certain environmental
conditions. The aim of the study is to examine individual
factors, psychosocial factors and the correlates of outcome
in children and adolescents with ODD, who attend the Child
andAdolescentoutpatientorinpatientservicesatNIMHANS.
This is a non- randomized observational prospective study of
naturalistic treatments (treatment as usual) of children and
adolescentswithODD,followedupforaperiodof3monthsin
atertiarycarecentre.About40caseshavebeenincludedinthe
studytilldate.
11.
A clinical study and short term outcome of
children and adolescents with history of child
sexual abuse. Dr. Sowmya Bhaskaran TS. Guides:
Annual Report
Dr. Shekhar P Seshadri, Dr. Shoba Srinath, Dr.
Satish C. Girimaji, Dr. K. John Vijay Sagar
Childsexualabuseisassociatedwithawiderangeofpsychiatric
symptoms and difficulties, and these problems can persist over
years.Athoroughexplorationoftheseconsequencesandthefactors
thataffecttheoutcomeisvitalinordertoformulatemanagement
andpreventativestrategiesforsexuallyabusedchildren.Theaim
of the study is to examine the clinical characteristics and shorttermoutcomeofsexuallyabusedchildrenandadolescents.Thisis
acasecontrolprospectivestudyofchildrenandadolescentswith
ahistoryofchildsexualabusecomparedwithcontrolswhohave
nohistoryofchildsexualabuse,followedupforaperiodofthree
monthsinatertiarycarecentre.Eighteencasesand10controls
havebeenrecruitedinthestudy.
12.
Study of suicidality in children and adolescent in
an inpatient setting. Dr. Arun Vangili. Guides: Dr.
Shoba Srinath, Dr. Satish Girimaji, Dr. Shekhar
Seshadri, Dr. John V Sagar
The aim of the study is to examine the prevalence and
clinical characteristics of suicidality in children admitted
to an in-patient facility. Children who are admitted to the
Child Psychiatry Centre, NIMHANS, who fulfil the inclusion
criteria, are diagnosed using a structured assessment method
after consent from the parents and assent from the child are
obtained. All the children without developmental disorders
are screened for suicidality and children who are positive are
assessed for severity of suicidal ideation using appropriate
instruments. Children with developmental disorders are
screenedforsuicidalityusingasemi-structuredquestionnaire
anddimensionsofproblembehaviourassessed.Sofar,atotal
of 60 patients have been recruited. Statistical analysis will be
doneafterrecruitmentofallsubjectsiscompleted.
Clinical Neurosciences
1.
Imaging correlates of cognitive impairments in
essential tremors. Dr. Ketaki Swapnil Bhalsing.
Guides: Dr. Pramod K Pal, Dr. AK Gupta
2.
A longitudinal study of Mild traumatic brain
injury: Neuro imaging, cognitive function
outcome and ApoE gene polymorphism.
Dr. Ashok M. Guides: Dr. B Indira Devi, Dr.
Dhaval Shukla, Dr. Jamuna Rajan (Funding
by DST)
2013-14
3.
Acceleratedaging and schizophrenia: Clinical
and neuro immunometa boliccorrelates. Dr. Shiv
Kumar. Guides: Dr. BN Gangadhar, Dr. V Ravi
4.
Molecular genetic basis of radiation and chemoresistance in glioblastoma. Dr. Arun HS. Guides: Dr.
S Sampath, Dr. Vani Santosh, Dr. Arivazhagan A
Despite aggressive radiochemotherapy, the median survival
GBMpatientsisonlyabout14monthswiththemajorcauseof
death attributed to local recurrence arising from tumor cells
whichhaveinfiltratedintonormaltissueandhaveevadedcell
deathfollowingirradiationorchemotherapy.Theobjectivesof
thisstudyistounderstandtheroleofradioresistantmolecular
markers, such as IGFBP3, STST-1,Osteopontin, stem cell
marker;Maternalembryonicleucinezipperkinase(MELK)and
nicotinamide n-methyltransferase (NNMT) in glioblastoma
pathogenesis and to understand the role with regard to
chemo-resistanceandradiobiologyofGBM.Theexpressionof
MELKandNNMTinGBMtumorsandothergradesofdiffuse
gliomashas been studied and prognostic significance is being
analysed.Radiobiologyexperimentshavebeencarriedoutand
thestudyisinprogress.
5.
Study of functional connectivity in early
Alzheimer’s dementia. Dr. Rakesh B. Guides: Dr.
Srikala Bharath, Dr. Sanjeev Jain
6.
Mitochondrial respiratory chain disorders:
Phenotypic, genotypic and functional correlation.
Dr. Sonam Kothari. Guides: Dr. Bindu PS, Dr.
Taly AB, Dr. Gayathri N, Dr. Srinivas Bharath MM
Mitochondrial respiratory chain disorders (RCD) are known
for phenotypic, biochemical and genetic heterogeneity.
This ongoing study in collaboration with the Departments
of Neuropathology and neurochemistry has successfully
established the respiratory chain complex assays for patients
with suspected mitochondrial disorders. Over the last two
years, a large cohort of patients with both syndromic and
nonsyndromic mitochondrial disorders has undergone the
phenotypic assessment and biochemical assays. The most
commondeficiencyobservedwascomplexIandIVfollowedby
combinedenzymedeficiency.
7.
Adenosine signaling pathway in medically
refractory epilepsy due to mesial temporal
sclerosis (MTS) lesions. Dr. Vikas Dhiman.
Guides: Dr. Sanjib Sinha, Dr. P Satishchandra,
Annual Report
2013-14
Dr. Anuranjan Anand, Dr. Anita Mahadevan, Dr.
Arivazhagan A (Funding by ICMR)
The aim of this study is to find out the role of various genes
involvedintheadenosinesignalingpathwayAdenosinekinase,
A1 receptor,5’nucleotidase,adenosinedeaminase,c-myc,c-fos,
c-jun, CREB1, ERK1/MAPK1, NF-kB), in medically refractory
epilepsy due to MTS using surgically resected hippocampal
tissuesfrompatientsofMTS.Expressionprofileofthesegenes
willalsobetestedinbloodsamplesofthepatientsinanattempt
tofindbiomarkersforprognosis.
8.
Macro
and
microstructural
videopolysomnographic signal analysis: Sleep and
epilepsy correlation. Dr. Chetan S Nayak. Guides:
Dr. Sanjib Sinha, Dr. AB Taly
9.
Role of Renin-Angiotensin-Aldosterone system in
cognitive deterioration in patients with cerebral
small vessel disease. Dr. Thomas GregorIssac.
Guides: Dr. Chandra SR, Dr. Rita Christopher,
Dr. Jamuna Rajeswaran, Dr. Mariamma Philip
(Funding by ICMR)
The objectives of this research are to study the phenotypic
characteristics of cerebral small vessel disease, correlate the
same with imaging and neuropsychological parameters and
to examine the association of gene polymorphisms of the
renin-angiotensin-aldoseterone pathway in determining the
progressionofcognitivesymptoms.Bloodsamplesofpatients
arebeingcollected andprocessed,andinitialneuropsychological
assessmentforexecutivedysfunctionisbeingcarriedoutonthe
recruitedpatients.
10. Simultaneous EEG FMRI to study phase
synchronization and functional connectivity
in symptomatic localization related epilepsy.
Dr. Ganne Chaitanya. Guides: Dr. Satish
Chandra, Dr. Sanjib Sinha, Dr. Rose Dawn
Bharath
13.
Genetic characterisation of respiratory chain
disorders in pediatric population. Dr. Shwetha
Chiplunkur. Guides: Dr. Bindu PS, Dr. Taly AB,
Dr. Gayathri N, Dr. Srinivas Bharath MM
Diagnosingmitochondrialdisorderisachallengetoclinicians.
Routine biochemistry, respiratory enzyme assays and genetic
analysis form the investigatory battery for mitochondrial
disorders. The investigators are already successful in
functionally assessing complexes of mitochondrial electron
transport chain. A more obvious next step is to confirm the
dysfunction by providing a genetic validation. Since all of the
mitochondrial dynamics is run by mitochondrial and nuclear
genes,itisimportanttoanalyseboth.Inthepurviewofavailable
resources,identifyingdeletionsanddepletionsinmitochondrial
genome, with few known, nuclear gene mutations affecting
mitochondrialfunctioningareaimedat,incollaborationwith
MolecularGeneticsLab.
14.
A study of inflammatory markers and heart
rate variability in severe head injury. Dr. Akhil
Deepika. Guides: Dr. Indira Devi B, Dr. Dhaval P.
Shukla, Dr. Rita Christopher, Dr. Sathyaprabha
TN
This study aims at identifying inflammatory markers and
heartratevariabilityasbiomarkersforfunctionaloutcomein
severetraumaticbraininjury(TBI).Clinicalandneuroimaging
findingsarerecordedinTBIpatients.Inflammatorymarkers
aremeasuredandheartratevariabilityrecordedondays1,3
and10aftertheinjury.Basedonoutcomemeasures,patients
are divided into 3 groups: (i) Brain Dead, (ii) Favorable
outcome (GOSE 5 to 8) (iii) Unfavorable outcome (GOSE 1
to 4). The collected data will be analyzed with appropriate
statistical measures to study the correlation between
autonomic function changes and inflammatory markers and
functionaloutcome.
Clinical Psychology
11.
Austism spectrum disorders–Role of oxytocin
and imaging analysis. Dr. Sowmyashree. Guides:
Dr. Shoba Srinath, Dr. Satish Chandra Girimaji,
Dr. Rose Dawn Bharath
1.
12.
Vitamin D, autoimmunity and autism spectrum
disorders. Dr. Salah Basheer. Guides: Dr. Satish
C Girimaji.
The aim of the study was to explore emotional, behavioral
and social influences on academic success among 6-7 yearoldchildren.Atotalof200childrenattendingregularschools
Emotional, behavioral and social influences
on academic success among 6-7 year-old
Indian children. Investigators: Dr. Uma H, Dr.
Subbakrishna DK (Funding by ICSSR)
Annual Report
were recruited for the study. Tests were used to assess
psychological functioning, social preference, intelligence
and learning disabilities. Academic success was measured by
a standardized test as well as from marks obtained in class
tests. Multiple linear regression and discriminant functional
analysis was used to analyze the data. On the teacher rated
measure of academic success peer relation problems as
observed by teacher in the class room along with likability of
thechildandintelligenceaccountedfor41.9%ofthevariance
in academic success. Knowledge of alphabets, numerals,
social preference in the class room and problematic behavior
observed by teacher in the classroom discriminated average
andaboveaveragechildrenontheresearcherratedmeasureof
academicsuccess.Theresultssuggestamodelhighlightingrole
of behavioral variables (inattention; hyperactivity and global
difficulties)socialvariables(peerproblems,socialpreference)
and cognitive variables (intelligence, knowledge of alphabets
andnumbers)wereidentifiedasinfluencingacademicsuccess.
Thefindingshaveimplicationsfor childrenatriskforacademic
under achievement and for developing intervention packages
domainsofchildbehavior.
2.
Efficacy of Partial Exposure and Response
Prevention (ERP) Vs. Conventional ERP Vs.
Mindfulness integrated CBT for patients with
Obsessive Compulsive Disorder: A randomized
control trial. Investigators: Dr. Mahendra P
Sharma, Dr. Devvarta Kumar, Dr. Paulomi M
Sudhir, Dr. Manjula M, Dr. YC Janardhan Reddy
This study examines the relative efficacy of partial exposure
and response prevention (ERP) Vs. conventional ERP Vs.
mindfulness integrated CBT for patients with obsessive
compulsive disorder. A sample of 30 patients with primary
diagnosis of OCD will be randomized to one out of the
three intervention groups. Patients in all the three groups
will undergo 15-20 sessions of therapy. Pre, mid and postassessments will be carried out. Tools used to assess OCD
symptoms, symptom severity, insight, obsessive beliefs,
subjective distress, depression, improvement, mindfulness,
qualityoflife,workingallianceandhomeworkcompliancewill
beincludedinthestudy.Theresultsofthepresentstudywillbe
analyzedquantitativelyaswellasqualitatively.
3.
Aggressive driving and anger on roads among two
wheeler riding college youth. Investigators: Dr.
Seema Mehrotra, Dr. Paulomi Sudhir, Dr. Manoj
Sharma, Dr. Neelima Chakrabarthy, CRRI, New
Delhi (Funding by CSIR)
2013-14
This project aims at examining the prevalence of aggressive
drivingamongsttwowheelerridingcollegeyouth,thecorrelates
ofthesameaswellasdocumentingtheexperienceofnegative
emotions, especially anger on the roads. An intervention
program for promoting safe and respectful riding behaviors
in youth (SMART RIDERS) has been developed. It has been
field tested and the data are being analyzed with respect to
gains in knowledge, changes in riding attitudes and efficacy
aboutemotionalregulationontheroads.Amanualfortrainers
is being developed for wide dissemination of this preventivepromotiveinterventionprogram.
4.
Youth Engagement program: Development
and examination of psychosocial outcomes.
Investigators: Dr. Seema Mehrotra, Dr. Srikala
Bharath, Dr. Ravikesh Tripathi (Funding by
ICSSR)
The study is aimed at developing brief program for youth
engagementandfieldtestingthesameinordertoexamineits
psychosocial impact. The pilot phase entailed examining the
psychometricpropertiesoftherelevantassessmentmeasures/
outcome indicators. A brief youth engagement program
(ENGAGE TO CHANGE) has been developed which consists
of an orientation workshop and an extended support phase
fortheparticipatingyouthtoimplementtheirplansdeveloped
duringtheorientationworkshop.Thethemescoveredforyouth
engagementinthisprograminclude:mentalhealth,disability,
environment and road safety. The program is currently being
fieldtested.
5.
Brain correlates of creativity. Investigators: Dr.
Jamuna Rajeswaran, Dr. K Thennarasu (Funding
by DST)
Creativity is defined as something new or novel, unique or
originalwithanelementofsurpriseandusefulness.Creativity
is appreciated, useful and required in all spheres from a
very simple invention of a consumer product to as complex
inventionofamissile.Researchincognitiveneurosciencehas
used predominantly EEG/ERP paradigm. This paradigm has
not been extensively used even in creativity research. EEG is
useful in understanding the temporal and spatial resolution
ofcognitiveprocesses.Thestudywillbehelpfulinidentifying
thebrainprocessinvolvedincreativityandalsowhichregions
mediatecreativity.Asampleof60subjectswillbechosenfrom
Bangalore.ThirtysubjectswillbetakenfromSchoolofDesign
from Bangalore (National Institute of Design, Shristi School
of Design, Chitra Kala Parishat) and 30 subjects will be from
Annual Report
2013-14
normalpopulation.Afterobtainingwritteninformedconsent,
the recording of the EEG will be carried out based on the
changesmadeafterthepilotstudyon60subjectsindividually.
6.
A study of cognitive functions and biochemical
correlates
in
traumatic
brain
injury.
Investigators: Dr. Jamuna Rajeswaran, Dr. Rita
Christopher (Funding by DBT)
Traumatic brain injury (TBI) is a complex injury with a
broadspectrumofsymptomsanddisabilities.Theimpacton
apersonandhisorherfamilycanbedevastating.Cognitive
difficultiesareverycommoninpeoplewithTBI.Studieshave
shown Neuropsychological rehabilitation to be usefulness in
improvingthecognitivefunctionsanddaytodayfunctioning.
Neurofeedbacktrainingisanoperantconditioningprocedure
whereby an individual modifies the amplitude, frequency
or coherence of the electrical activity of his/her own brain.
The aim of the present study is to examine the biochemical
correlatespre,postneuro-feedbacktraining(NFT)inpatients
with TBI. Sixty patients diagnosed with TBI according to
ICD-10 (WHO, 1992) will be recruited to one of the two
groups within a month of injury into intervention group
(neurofeedbacktraining)andtreatmentasusual.Theserum
levelsoftheabovewillbecomparedbeforeandafterNFTin
bothgroupstoelucidatethebiochemicalmechanismswhich
mayapossibleroleintherecovery.Thestudywillbehelpful
inadministeringtheNFTintheearlystagesofTBI,indicating
thatalongwithneuralplasticityNFTaugmentsimprovement
cognitionandQOL.
7.
Parenting styles and socialization processes
in the development of perfectionism: An
intergenerational study of Indian youth.
Investigators: Dr. Paulomi M Sudhir, Dr. DK
Subba Krishna (Funding by ICSSR)
The project was aimed at understanding the development
of perfectionism in youth with parenting styles as possible
contributors and examining dimensions of perfectionism,
parenting styles attachment styles and neuroticism in Indian
youth.Ayouthsampleof400wasdrawnfromcolleges.Asecond
setofdata,whichcomprisedofparentsandyouth,wasrecruited
from community (n=57). Intergenerational transmission of
perfectionismwasanalyzed.Perfectionismwasnotassociatedwith
greater psychological distress. There were positive correlations
betweenself-orientedperfectionism,discomfortwithcloseness,
preoccupationwithrelationship,confidenceinrelatingtoothers.
Self-orientedperfectionismwasassociatedwithananxiousand
secureattachmentstyle.Avoidant,anxiousstyleswerepositively
correlated with Neuroticism and higher psychological distress.
Women showed higher self-oriented perfectionism. There
was a negative association between psychological distress and
maternalandpaternalcare,whileoverprotectionbyfatherand
an authoritarian style of parenting as perceived by the sample
was positively associated with psychological distress. There
were significant differences between high and low distressed
subjects on neuroticism, socially prescribed perfectionism.
Therewassignificantpositivecorrelationbetweenotheroriented
perfectionism in youth and parents, and positive correlation
between self-oriented perfectionism in youth and parents.
Sociallyprescribedperfectionismwasnegativelycorrelatedwith
self-orientedperfectionisminparents.
8.
Electrophysiological correlates of cognitive
decision making and emotional decision making.
Investigator: Dr. Keshav Kumar (Funding by DST)
The aimof the study is to compare the nature of information
processing in cognitive decision making(monitory loss/gains)
with emotional decision making (romanticloss/gains). The
Neuralcorrelatesofcognitiveandemotionaldecisionmaking
will be examined using EEG and ERP and fMRI in healthy
normalsandindividualswithalcoholdependence.
9.
Exploration of need and efficacy of internet based
program for the management of psychological
problems. Investigator: Dr. Manoj Sharma
(Funding by Dr. Ramamurthy Foundation for
Mental Health & Neurological Sciences)
Internetasamediumofmasscommunicationposesnumerous
opportunities, challenges and dilemmas for mental health
professionals.Theproposedinternet-basedprogramprovided
the authentic educative information about psychological
problems as well as online guidance to manage their day-today stressors. The sample consisted of 500 subjects (both
male and female) in the age range of 20-50 years recruited
from the general community for the assessment of felt needs
fortheprogramandscreeningofpsychologicalproblemsand
50 subjects amongst them (with presence of psychological
problems–anxiety,depression,somaticcomplaintsandstress,
familiarity with the internet usage) were recruited for the
internet-basededucational program. The education program
consistedofassessment(intheformofquestion-answerformat)
ofproblems,educatingthemaboutthepsychologicalproblems,
identifying unhelpful, irrational thoughts/coping behaviors
andstrategiesrequiredtohandlethem.Weeklysessionswere
Annual Report
conductedandparticipantsweregivenhomework/worksheet
assignmenttofacilitatepracticebetweenthesessions.
10.
Computer
assisted
cognitive
retraining
programme to improve cognitive functions for
elderly. Investigators: Dr. Keshav Kumar, Dr.
Varghese M, Dr. John PJ, Dr. Jain S, Dr. Bagepally
BS (Funding by DST-TIDE program)
Normalagingisassociatedwithcognitivedeclineinthedomains
of memory, speed of processing and executive function. Mild
CognitiveImpairments(MCI)isknowntobeatransitionstage
betweennormalaginganddementia.Tento15%ofindividuals
withMCIwilldevelopdementiaplacingademandoncaregivers
andmedicaltreatment.Specificallydesignedcognitivetraining
programmes are known to reduce the risk of rapid cognitive
decline in healthy normal elderly, individuals with MCI and
dementia. Improvement in cognitive function improves
the quality of life; possibly delay dementia and decreases
dependence.Thepilotstudyindicatedimprovementincognitive
functionsinthedomainsofattention,workingmemory,verbal
andvisuallearningandmemoryinbothhealthynormalsaswell
as clinical population (MCI and mild Dementia patients). The
preliminaryfindingsuggestthatcognitiveretrainingprogramme
ispromisinginimprovingcognitivefunctioninhealthynormals
aswellasclinicalpopulation.
11.
Behavioral addiction in the community: An
exploration. Investigators: Dr. Manoj Sharma,
Dr. Vivek Benegal, Dr. Girish N (Funding by
ICMR)
A total of 2755 subjects in the age group of 18-65 years were
interviewed at their door steps from an urban locality in
Bangalore.ThestudywasfundedbyIndianCouncilofMedical
Research, Delhi undertaken by the department of Clinical
Psychology, Center for Addiction Medicine and Centre for
Public Health, NIMHANS, Bangalore. Addictive use was
presentfor-1.3%(2%males&0.6%females)forinternet;4.1
%(5%males&3.1%females)formobilephonesand3.5%for
social networking sites. Physical/Psychological distress was
presentasmorbidity—6.8%withmobilephoneaddiction;4.2%
withinternetuseand3%withsocialnetworkingsites.
12.
Stress management in youth: A preventive
intervention. Investigators: Dr. M Manjula, Dr.
Roopesh BN, Dr. Mariamma Philip (Funding by
Indian Council for Social Science Research)
2013-14
Specific objectives of the study are (i) To develop a prevention
program and examine its efficacy in a) reducing depression b)
reducing suicidal behaviours c) enhancing knowledge d) coping
and d) building self-esteem (ii) To prepare module for suicide
preventionforyouth.
The approximate sample size for the exploratory study is
1500 from two government and two private high schools and
pre-university colleges using stratified random sampling. The
interventionstudywoulduseatwogroupcomparisondesign.
The sample for study group would consist of students from
one private and one government school (300) and similarly
for college (around 380). In addition, 200 students from
school and college were assessed for validation of suicidal
behavioursscale.Thedatacollectionforexploratorystudyhas
been initiated and module development for the intervention
programisunderway.
13.
Neural effects of cognitive remediation in
schizophrenia: An ERP and fMRI study.
Investigators: Dr. Devvarta Kumar, Dr. BN
Gangadhar, Dr. Ganeshan Venkat Subramanian,
Dr. Shivram Varamabally, Dr. Rose D (Funding by
DBT)
This study aims to see the neural effects of cognitive
retraining (specifically home-based training) in patients with
schizophrenia. The schizophrenia patients will be randomly
divided into three groups – home-based remediation group,
clinic-basedremediationgroupandthewait-listcontrolgroup.
Pre-andpost-neuropsychologicalandneurophysiological(fMRI
andEEGbasedERP)changeswillbeassessedtodeterminethe
effectsofremediation.Thepilotphaseoftheprojectisoverand
themainphasehasstarted.
14.
Determining sensitivity and specificity of Event
Related Potentials for its use as cognitive function
biomarker in Schizophrenia. Investigators: Dr.
Devvarta Kumar, Dr. Shivaram Varamabally,
(Funding by DBT)
This study is intended to see the sensitivity and specificity of
variousEEGbasedEvent-RelatedPotentialsinschizophrenia.
TheERPparadigmshavebeendevelopedandtheprocessfor
recruitmentofJRFhasbeenstarted.
15.
Self-injurious behaviours and psychopathology
among adolescents and young adults in
Annual Report
2013-14
Bangalore. Investigators: Dr. Poornima Bhola,
Dr. Manjula M (Funding by ICMR)
Thestudyexploredtheoccurrence,methods,characteristicsand
reportedreasonsforSelf-InjuriousBehaviours(SIB)among1571
high school, pre-university and undergraduate college students,
anditssocio-demographicandmentalhealthcorrelates.Results
indicated that 40.7% reported SIB in the past year, with male
preponderance and higher rates among youth between 13-
below 18 years. The rate of non-suicidal self-injury was 33.9%.,
with 16.7% of self-injurers reporting associated suicidal intent.
Moderate/severe forms of SIB were reported by 19.4%, most
commonly cutting (8.2%) and burning (7.7%). 21.3% used only
minormethods;mostfrequentlybitingself(19.6%)andself-hitting
(17.2%).Multipleself-injurymethodsweremostoftenendorsed
and 14.8 years was the mean age of onset. Characteristics like
durationofforethought,associatedlevelsofpainandconcurrent
substanceuseweredescribed.DistinctivepatternsofSIBemerged
basedongender;theseverityofmethodsused;andthepresence
orabsenceofsuicidalintent.SIBservedbothtoregulateinternal
emotional states (automatic reinforcement) and to influence
others in the environment (social reinforcement). Self-injuring
youthhadsignificantlyhigherlevelsofinternalizing,externalizing
andtotalproblems.Separatelogisticregressionanalysesidentified
predictors of the occurrence of self-injurious behaviours and
predictorsofsuicidalintentamongself-injuringyouth.
16.
Professional development of clinical psychology
trainee therapists. Investigators: Dr. Poornima
Bhola, Dr. Ahalya Raguram (Funding by
NIMHANS Intramural Research Grant)
This study aims to assess therapist characteristics, positive
and negative aspects of work experience and professional
development among Clinical Psychology trainee therapists in
India.Thisincludedtheoreticalorientation,sourcesoflearning,
therapeutic skill, perceived progress, therapeutic difficulties
and coping strategies, cultural aspects of psychotherapeutic
practice, interpersonal manner, personal functioning and
satisfactionwithsupervisionandthetrainingsetting.Thepilot
study hasbeencompleted. Thisinvolvedinterviewswithfour
psychotherapysupervisorsandfinalisationofTheDevelopment
of Psychotherapists Common Core Questionnaire – Trainee
version, Background and Process forms after administration
and feedback from 10 Clinical Psychology trainee therapists.
Themainstudyisongoing.Sixtyfivetraineetherapistsfromthe
Department of Clinical Psychology and select M.Phil Clinical
Psychologytraininginstitutesacrossthecountrycompletedthe
assessmentattheendoftheirtraining.Atwo-pointassessment
hasbeencompletedforasub-sampleof16traineetherapists;
at mid-point and at the end of training to assess changes in
variousdomainsofprofessionaldevelopment.
17.
Explanatory models of mental illness among
caregivers of mentally ill referred to rehabilitation
services. Investigators: Dr. Poornima Bhola, Dr.
Hesi Herbert, Dr. Devvarta Kumar, Dr. Sailaxmi
Gandhi, Dr. SK Chaturvedi
This project aims to study the explanatory models of mental
illness among caregivers of individuals with psychiatric
disordersseekingtreatmentatatertiarycareneuropsychiatric
hospital.Theobjectivesaretoexploretheexplanatorymodels
ofcaregiversofmentallyillandtostudytherelationshipwith
socio-demographic variables and select clinical variables.
The sample will consist of 60 caregivers of inpatients or
outpatients,withapsychiatricdiagnosisreferredtoPsychiatric
Rehabilitation Services. The study is exploratory in nature
with a single group and purposive sampling. The tools used
for assessment are Socio Demographic Data Sheet and Barts
ExplanatoryModelInventory.
18.
Electrophysiological and neuropsychological
correlates of treatment outcome in ADHD
children. Investigators: Dr. Roopesh BN, Dr.
Shoba Srinath, Dr. Satish Girimaji, Dr. Shekhar
Seshadri, Dr. John Vijayasagar, Dr. Keshav
Kumar (Funding by DBT)
Theprojectaimstolookatthecorrelatesintheneurodynamics
(neuropsychological and electrophysiological) of the brain
of the children diagnosed with ADHD after they were given
cognitivetraininginadditiontotreatmentasusual.
19.
Just World Belief in parents of children with
conduct disorder. Investigators: Dr. Roopesh BN,
Dr. John Vijayasagar
Thehypothesisof‘JustWorldBelief’(JWB)statesthatpeople
have a need to believe that their environment is a just and
orderly place where people usually get what they deserve.
Conduct Disorder (CD) is a repetitive and persistent pattern
ofdissocial,aggressiveordefiantconductbehavioursthatare
diagnosed in children. Among various risk factors, parental
psychopathology such as antisocial personality disorder,
substance use, and depression is observed in the parents of
childrenwithCDcomparedtoparentsofchildrenwithoutCD.
Giventhis,thecurrentstudylookedhowJWBdifferbetween
Annual Report
parents of children with and without CD. For the same, 15
parents of children with CD were taken from inpatient and
outpatientservicesofNIMHANS,afterfulfillingtheinclusion
andexclusioncriteria.Asacomparisongroup,ageandeducation
matched15parentsofchildrenwithoutCDwererecruitedfrom
the community. The results showed no significant difference
betweenthetwogroups.
20. Development and standardization of flipchart
on informed assent for children who participate
in research. Investigators: Dr. Roopesh BN, Dr.
Jayashree Ramakrishna, Dr. John Vijayasagar
The aim of the project was to develop a flipchart for the
children who are approached to participate in various
researchactivitiesandareexpectedtoread,understandand
signtheinformedassent.Giventhattheyoungchildrenhave
difficulty to comprehend written and verbal instruction;
a flipchart of the informed consent was developed. This
flipchartwascomparedwiththeverbalinformedconsentin
childrenbetween6–16yearsofage.Theresultsshowedthat
agehadasignificantpositivecorrelationwithunderstanding
the informed consent. Results further showed that girls
preferred more of verbal and boys preferred more of visual
stimuliforinformedconsent.
21.
Development and standardization of insight in
conduct disorder scale in children. Investigators:
Dr. Roopesh BN, Dr. Manoj Sharma, Dr. John
Vijayasagar
22. Development and standardization of belief in
just world scale for children. Investigators:
Dr. Roopesh BN, Dr. Manoj Sharma, Dr. John
Vijayasagar
23. Decision making in patients with ADS.
Investigators: Dr. Roopesh BN, Dr. Manoj
Sharma, Dr. Vivek Benegal
PatientswithAlcoholDependentSyndrome(ADS)haveshown
tohavedeficitsinvariousdecisionmakingprocesses,especially
in gambling type of tasks. However, in some of the gambling
tasks,thepersonhastorememberthegainorlossofaparticular
choice.Inadditiontoplacingdemandonmemoryresources,it
rarelyresemblesthereallifegamblingexperiences.Therefore,
theprojectaimstostudytheperformanceofthepatientswho
arealcoholdependentintasksthatmimicthereallifegambling.
2013-14
24. Integrated treatment for in timate partner
violence and alcohol use for heavy drinking men
in South India. Investigators: Dr. Satyanarayana,
VA, Dr. K Srinivasan (Collaboration with St.
John’s Research Institute, funding by SBR/ICMR)
The aim of the study is twofold: (a) To explore perpetration
and victimization experiences of problem drinking inmen and
their wives, and (b) To examine the comparative effectiveness
of standard intervention (treatment as usual) and enhanced
intervention(standardpluscognitivebehavioralintervention)for
problemdrinkinginmen,knowntoperpetrateIPV.Theprimary
objectivesaretocomparetheeffectofstandardversusenhanced
interventions in reducing (a) alcohol consumption among
problemdrinkers(b)thefrequencyofperpetrationofIPVamong
problem drinkers (c) the frequency of IPV related victimization
among wives of problem drinkers. The secondary objectives are
tocomparetheeffectofstandardversusenhancedinterventions
inreducing(a)symptomsofdepression,anxietyandstressamong
wives of problem drinkers and (b) emotional and behavioral
problemsinchildren.Thestudyisconductedintwophases:the
formativephaseandtheinterventionphase.Theformativephase
is completed and a manuscript based on the findings has been
submitted for publication. The intervention phase is currently
in progress and recruitment of 177 patients for the control and
interventiongroupshasbeencompleted.About130patientswere
followedupinthefirstmonthand108afterthreemonths.
25. Efficacy of a nurse delivered mobile phone
intervention in improving adherence to HIV
treatment and mental health outcomes in women
with HIV: A feasibility RCT. Investigators: Dr.
Satyanarayana VA, Dr. Chandra PS (Funding by
NIH/ICMR)
The objectives of the study are: (a) conducting formative
researchtoadaptaNurse-deliveredmobilephoneintervention
forwomenwithHIVwhohavementalhealthorpsychosocial
barriers. This part of the research will inform the content of
theinterventionandhelptoadapttheexistinginterventionfor
Indianneeds(b)trainingIndiannursestodeliverthetheoryguided, standardized phone intervention for mental health
issuesandpsychosocialbarrierstoimproveARTadherenceand
retentionincareandimproveclinicaloutcomes(c)evaluating
the feasibility, acceptability, fidelity and preliminary efficacy
of the standardized phone intervention in a randomized,
controlled pilot study, in which 120 HIV-infected women are
randomized to treatment as usual or treatment as usual plus
Annual Report
2013-14
the phone intervention. Recruitment and training of research
staff for the formative phase of the study has been done.
Formativephasehasbeeninitiated,andqualitativeinterviews
on women with HIV/AIDS, their family members and health
careprovidersarecurrentlyongoing.
26. Effect of Indian classical music on perceived
anxiety, depth of anesthesia and cortisol level in
patients undergoing spinal surgery: A double blind
randomized controlled study. Investigators: Dr.
Shantala Hegde, Dr. GS Umamaheswara Rao, Dr.
Rita Christopher, Dr. Gopala Krishna KN (Funding
by NIMHANS, Intra-mural research grant)
Perioperative anxiety remains a major issue for patients
undergoing any surgical procedure. Recent developments in
anaesthesia have contributed to satisfactory management
of systemic physiology during and after surgery, but total
management of pain and anxiety remains less than ideal.
Pharmacological approach to the problem is fraught with
addedrisksintheformofcardiorespiratoryandothersystemic
complications. Recent studies point to the deleterious effects
ofdeepintra-operativeanaesthesiaonpostoperativeoutcomes.
Research studies examining the effect of music on health
have reported that music has beneficial effect in lowering the
usageofsedativedrugs,aswellasinloweringofstresslevels
assessed via behavioral as well as physiological measures in
patients undergoing various kinds of surgery. This study is a
double blind randomized controlled group study using ragas
ofNorthIndianclassicalinstrumentalmusic(NICM)isbeing
carried out on patients subjected to a uniform technique of
anesthesiaduringspinalsurgery.TheeffectofNICMonstress
levelassessedbothbehaviorallyaswellasusingphysiological
measures such as cortisol level, heart rate variability, blood
pressure—anddosageofsedativedrugsanddepthofanesthesia
in patients undergoing spinal surgery—is being examined. So
far,42patientshavebeenrecruitedfortheresearchstudy.
27.
Perception and identification of ragas of
Indian
classical
music:
An
exploratory
electrophysiological study. Investigator: Dr.
Shantala Hegde (Funding by DST)
The present study is aimed to examine the EEG/ERP changes
in musically trained and untrained participants while passively
listeningtoragaexcerptswithnotesthataremelodicallycongruent
yet theoretically incorrect notes (incongruent note) that do not
conform to the raga. The sample consisted of musically trained
(n=30) and musically untrained participants (n=34). EEG was
recordedusingtheNeuroscan(SynAmps),samplingrateof256Hz,
with30electrodesplacedaccordingthe10/20electrodeplacement
system. ERP analysis was carried out using scan software (4.5).
ERPduringcongruentandincongruentnotepresentationunder
eachragaexcerptsweregrandaveragedundereachgroup.Results
showedsignificantdifferencebetweenthetrainedanduntrained
group.WhilsttrainedgroupshowedP600ERPcomponentduring
the incongruent note presentation, the untrained group did not
show any significant difference between the two conditions.
Interestingly,theP600isalanguage-relevantERPandisthought
tobeelicitedbyhearingorreadinggrammaticalerrorsandother
syntacticanomalies.Inthisstudy,themusicallytrainedseemedto
haveprocessedmusicalexcerptssimilartolanguageandanomaly
in musical excerpt similar to grammatical errors. The results
provided further evidence to our understanding of shared and
distinctneuralcorrelatesofmusicandlanguage.
28. Electrophysiological changes and autonomic
response variations to happy and sad emotion
induced via music and a functional MRI study of
musical emotions Investigator: Dr. Shantala Hegde
(Funding by Department of Science and Technology
(Fast Track Scheme for Young Scientist)
The aim of the study was to investigate the neural correlates of
musical emotions using excerpts of ragas and functional MRI
method. This is the first study of its kind to investigate musical
emotionsviaragasofnorthIndianclassicalmusic.Thestudyalso
aimedtoexaminethedifferencesandsimilaritiesintheactivation
of the brain areas in musically trained (n=11) and untrained
individuals(n=17)duringthetwomusicalemotionconditions.The
stimuluswaschosenbasedonapriorbehaviouralstudyinwhich
musicallytrained(n=30)andmusicallyuntrained(n=31)ratedset
ofmusicalexcerptschosenfromsixragasofHCM.Ofthesixraga
excerpts,theexcerptratedassignificantlyevoking‘veryhappy’and
‘very sad’ by both the groups were chosen for the present fMRI
study.Blockdesign(ABA)methodwasusedinthepresentstudy.
Thebrainactivationduringthetwoemotionalconditionsdiffered
significantlywithmorenumberofbrainareasbeingactivatedduring
happy condition compared with sad condition in both musically
trainedanduntrainedgroup.Apartfromtheactivationofprimary
auditory areas and emotion areas such as para-hippocampal
region, activation in right insula and right medial, inferior and
superiorfrontalareaswereobservedinhappycondition.Thesad
condition activation in the putamen, right thalamus, caudate,
precentralgyrus,leftinsulaandleftfusiformgyruswereobserved.
The findings contribute to the further understanding of musical
emotionsanditneuralcorrelatesandvariationsintheunderlying
neuralcorrelatesduetomusicaltraining.
Annual Report
2013-14
(c)
(a)
(d)
(b)
Voxel based morphometry group analysis. Figures (a) and (b)show the brain activation
during happy and sad musical emotion in musically untrained group and (c) and (d)
show the brain activation during happy and sad musical emotion in musically trained
group. Apart from the primary auditory areas and emotional areas, some of the brain
areas observed to be activated in musically trained group was not observed in the
musically untrained participants and during sad emotion condition, musically trained
participants activated more number of areas than the untrained.
Annual Report
2013-14
29. A study of client characteristics in the process
and outcome of psychotherapy. Ms. Mahima
Sukhwal. Guide: Dr. Ahalya Raguram
32. Childhood Leukaemia: An exploratory study of
a hospital-based psychological intervention. Ms.
Uttara Chari. Guides: Dr. Uma Hirisave, Dr. L
Appaji
The aim of the study was to examine client pre-therapy
characteristics in the process and outcome of therapy. These
includedclients’roleandoutcomeexpectancies,motivationfor
psychotherapyandinterpersonalfunctioning.Processvariable
includedclients’ratingsofworkingallianceandoutcomewas
ratedbyclientsandanindependentclinician.Pessimismabout
outcome and overall working alliance predicted improvement
on clients’ symptom distress, social role and interpersonal
functioning. The role of positive versus negative expectancies
and intrinsic versus extrinsic motivation was found to be
more complex than previously understood. Working alliance
was found to have a positive association with the outcome of
psychotherapy.
The aim of the study was to explore the therapeutic effect of
a hospital based psychological intervention on children with
leukemia.Thesampleconsistedof20children,theirmothers
and primary nurse in-charge. The normal group comprised
of 20 healthy children and their mothers. Play therapy and
supportive counseling were carried out. There was difference
in play behavior in the two groups of children. Following
intervention there was decrease in psychological difficulties;
better adjustment to illness related stressors and improved
playbehavior.Thesegainsweremaintainedatfollow-up.Play
behavior showed decrease in anxiety and greater adaptive
defenses.
30. A psychosocial exploration of persons seeking
divorce. Ms. Suruchi Sonkar. Guides: Dr. Ahalya
Raguram, Dr. Suresh BM
33. Effectiveness of cognitive behavior therapy for
children with anxiety disorders in school setting.
Ms. Selvi M. Guide: Dr. Uma Hirisave
Divorceisoneofthemoststressfullifeeventsanindividualcan
experience.Evidencesuggeststhatmaritaldistress,conflictand
disruptionareassociatedwithawiderangeofdeleteriouseffects
on both adults and children, on physical health and mental
health and well-being. The aim of the study is to explore the
perceivedcausesofdivorceamongpersonsseekingdivorceand
examinetheirmentalhealthandpsychologicalcharacteristics.
These include communication, conflict resolution, social
support, well-being and emotional status. The study is being
carriedoutonpersonsseekingdivorcewhohavebeenreferred
formediationbythefamilycourts.
The study aimed to examine the effectiveness of cognitive
behavior therapy in children with anxiety disorders in school
setting in comparison to a control group. Fifty school-going
children aged 8 to 14 years were assessed on measures of
anxiety,worriesandglobalfunctioning.TheKendall’sCoping
Cat Programme was effective in reducing anxiety symptoms
andimprovementinglobalfunctioning,Theeffectsizeindicates
themagnitudeofchangeinanxiety,andglobalfunctioningwas
higherintheinterventiongroupthaninthecontrolgroup.
31.
Systemic therapy with families of youth with
mental disorders. Ms. Suvarna Joshi. Guides: Dr.
Ahalya Raguram, Dr. Mathew Varghese
Family therapy attempts to understand human behavior as
shaped by its context. Family functioning has significant
implicationsforthedevelopmentandwell-beingofindividual
members and includes the individual, marital and the overall
familylevels.However,therelativecontributionsofindividual
ordyadicfactorstooverallfamilyfunctioningarenotclearand
have not been examined in clinical samples. This study aims
to examine the impact of systemic family therapy in families
of youth with mental disorders on well-being, emotional
adjustment,dyadicadjustmentandoverallfamilysatisfaction
andidentifypredictorsofthesame.
34. Development of parent-training videos for child
behavior problems. Ms. Megha Rupa. Guides: Dr.
Uma Hirisave, Dr. Jayashree Ramakrishna
The aim of the study is to develop parent-training videos for
behavior problems in young children and evaluate its impact
onparentingsenseofcompetence.Datawillbecollectedfrom
parentstoidentifycommonchildbehaviorproblemsinchildren
in the community between 3-8 years of age. When data is
saturated,contentanalysiswillbeperformedandscreenplays
willbeprepared.Afterestablishingthevalidityandreliabilityof
thescreenplays,videoswillbeshot.Theimpactofthesevideos,
thusdevelopedwillbeassessedusingasinglegrouprepeated
measuresdesignintheevaluationphaseofthestudy.
35. Development of as caletoassess experiences
in children and adolescents. Ms. Snigdhasree
Annual Report
2013-14
Dr. Anisha Shah
Bhattacharyya. Guides: Dr. Uma Hirisave, Dr. N
Janardhana
The aim of the current study is to develop a scale to assess
experiencesinchildrenandadolescents.Thestudywouldexplore
howchildrenandadolescentsconceptualizeexperiencesintheir
day-to-day lives. Following which a scale will be developed to
assessexperiencesinchildrenandadolescents,andpsychometric
propertiesofthescalewillbeestablished.Thesamplewillinclude
school-goingstudentsbetween8–16yearsofagefromEnglish/
Kannada medium of instruction.Qualitative and quantitative
methodswillbeusedforanalysisofdata.
The objectives of the study are to explore and examine the
relationshipbetweensexualinteraction,sexualcommunication,
marital intimacy and marital quality in couples with sexual
dysfunction. A format for marital therapy in couples with
sexual dysfunction will also be developed and the effect of
marital therapy on the above variables will be examined.
An integrated marital sex therapy will also be developed. A
hybriddesignwillbeusedandPart1ofthestudywillbecrosssectionalwithasampleof250marriedindividuals.Part2will
involveInterventionwith20couples,withpre-postandfollowupassessments.
36. An exploratory study on gender, migration
and mental health in persons from the Khasi
community. Ms. Ila Lyngksiar Rynjah. Guide: Dr.
Anisha Shah (Funding by ICMR)
39. Client experiences in combined couples therapy.
Ms. Ashmeet Nagpal. Guide: Dr. Anisha Shah
Theaimistoexaminetheexperienceofmigrationandthemental
healthofpersonsfromtheKhasicommunitywhohavemigrated
to Bangalore, through a gendered perspective. The study
employs a mixed method design, wherein quantitative data is
beingobtainedusingscales,whichhavebeendecidedupon,and
qualitative data from the semi-structured interview which has
beenconstructedbytheresearcher.Thesampleforquantitative
data is 180, of which, 92 have been obtained so far. From the
180 samples, 30 persons will be interviewed. Currently, data
collectionisinprogress,followingwhichappropriatestatistical
andqualitativeanalysiswillbecarriedout.
37.
Differentiation of self, attachment and marital
quality in married persons. Ms. Madhurini
Vallikad. Guide: Dr. Anisha Shah
The aim of the study is to study differentiation of self,
attachmentandmaritalqualityinmarriedpersons.Thestudy
will employ a cross-sectional design comparing distressed
and non-distressed groups on the variables of interest. The
samplewillconsistof120marriedpersons.Thefollowingtools
will be administered to participants: The Socio-Demographic
data sheet, Beck’s Depression Inventory, Marital Quality
Scale,Differentiation of Self Inventory- revised, Attachment
Style questionnaire and Marital Intimacy questionnaire. In
addition, two of the questionnaires will be administered to a
sample of 150 participants from a community population to
generatenorms.
38. Marital therapy in couples with marital distress
and sexual dysfunction. Ms. Manjula V. Guide:
Theaimofthestudyistobridgetheresearcher-practitionergap
by using in-depth interviews with clients to understand how
individual sessions can be integrated with conjoint sessions in
couples’ therapy. Clients perceived needs and experiences of
individual and conjoint sessions can better inform therapists
in making treatment decisions. Additional variables of interest
thatwillbestudiedareindividualpsychopathologyinspouses,
maritalqualityandlevelsofdifferentiationofself,withtheaimof
understandingtheassociationofthesevariableswiththechoice
offormatofsessions.Thestudywilluseamixedmethoddesign.
40. Effectiveness of mindfulness integrated cognitive
behavior therapy (MICBT) in social phobia.
Mr. Abdul Salam KP. Guides: Dr. Mahendra P
Sharma, Dr. CR Chandrashekhar
The aim of the study was to examine the effectiveness of
MICBTinpatientswithsocialphobia.Thesampleconsistedof
47 patients who were randomly assigned to either of the two
groups–MICBT(n=25)orExposureonly(n=22).Assessments
weredoneatpre,postand1monthfollow-upphases.Results
indicated that MICBT is as effective as Exposure only in
reducing symptom severity in social phobia. MICBT was
effectiveinreducingcognitionsandmeta-cognitionsassociated
withsocialphobia.MICBTwasalsoeffectiveinenhancingthe
quality of life of these patients. Qualitative data reveals that
patientsperceivedMICBTtobehelpfulinproducingrelaxation,
decreasingdistress,reducingspectatorshipandavoidanceand
handlinginterpersonaltensions.
41.
Effectiveness of a mindfulness-based stress
reduction (MBSR) program in reducing stress
Annual Report
2013-14
in adolescents. Ms. Urvashi Anand. Guide: Dr.
Mahendra P Sharma
Thisstudyexaminedtheeffectivenessofamindfulness-based
stressreduction(MBSR)programinreducingstress,increasing
adjustment and enhancing well-being in adolescents. Sample
comprised of 192 adolescents from two schools. MBSR group
received eight 40-minute weekly sessions of the program
within the school hours while the control group received no
treatment. Pre-analysis results reveal significant differences
frompre-assessmenttopost-assessmentandpost-assessment
tothree-monthfollow-upassessmentonallthesubscalesofthe
SchoolSituationSurvey,thePre-AdolescentAdjustmentScale
and Personal Well-Being Index-School Children. Moderate to
largeeffectsizesemergedonalloutcomemeasuresindicating
the effectiveness of the program. Good compliance,high
attendance,highretentionratesandpositivefeedbacksupport
theprogram’sfeasibilityandacceptability.
42. Sexuality and quality of life in women survivors
of breast cancer. Ms. Michelle Sangeeta
Barthakur. Guides: Dr. Mahendra P Sharma, Dr.
SK Chaturvedi, Dr. Suraj Manjunath
Theobjectivesofthestudyistostudythepatternofbodyimage
issues, sexuality, marital satisfaction, anxiety, depression and
overallqualityoflifeinwomensurvivorsofbreastcancerandto
examinetherelationshipbetweenthesevariables.Quantitative
data was collected from 50 women and qualitative interviews
with 15 women for those meeting criteria of study. Results
revealdepressionaspredictorofqualityoflife;qualitativedata
suggests trends of good coping skills, difficulties encountered
with health care system, good social support and posttraumaticgrowth.Basedonfindingsofthestudy,contentsof
aninterventionmodulewillbeoffered.
43. Efficacy of mindfulness integrated cognitive
therapy in patients with OCD. Ms. Sonal Mathur.
Guides: Dr. Mahendra P Sharma, Dr. YC
Janardhan Reddy
TheaimofthestudyistoexaminetheefficacyofMindfulness
Integrated Cognitive Therapy (MICT) on symptom severity,
beliefs about obsessions, depression, quality of life and
psychological flexibility in patients with obsessive compulsive
disorder. A two-group design with baseline, post and followup assessments will be adopted. Sixty patients with primary
diagnosis of OCD will be randomly assigned to either MICT
intervention group or Stress Management intervention
group and each group will have 15 sessions of intervention.
Appropriate statistical measures will be used to assess the
improvementandcomparethetwogroups.
44. Effectiveness of acceptance and commitment
therapy in patients with somatic symptom
disorder. Ms. Fatema Khanam. Guide: Dr.
Mahendra P Sharma, Dr. SK Chaturvedi
TheaimofthestudyistoexaminetheeffectivenessofAcceptance
andCommitmentTherapy(ACT)onsomaticsymptoms,anxiety
anddepression,globalfunctioning,psychologicalwell-beingand
improvingacceptance,mindfulnessandvalued-livinginpatients
with somatic symptom disorder. A two-group design with
baseline,postandfollow-upassessmentswillbeadopted.Forty
patients with primary diagnosis of somatic symptom disorder
willberandomlyassignedtoeitherACTinterventiongroupor
treatment-as-usual group and the ACT group will have 8-10
sessionsofintervention.Appropriatestatisticalmeasureswillbe
usedtoassesstheimprovementandcomparethetwogroups.
45. Cognitions, Metacognitions, Neuropsychological
functioning and symptom dimensionality in
obsessive compulsive disorder. Ms. Manpreet
Kaur. Guides: Dr. Mahendra P Sharma, Dr.
Keshav Kumar, Dr. YC Janardhan Reddy
OCD is a heterogeneous condition. Recent research shows
one such method used to reduce this heterogeneity is to
examine symptom dimensions in OCD. It has been shown
that symptom dimensions have distinct but overlapping
brain substrates. There are also some early indications that
symptom dimensions might have distinct neuropsychological
correlates. However, it is unknown that whether symptom
dimensions in OCD are associated with specific dysfunctional
beliefs and metacognitions. Hence, the present study aims to
examineobsessivebeliefsandmetacogntionsinOCDsymptom
dimensions and their relationships with neuropsychological
functions
46. Life adversities, relational experiences and selfesteem in women with alcohol use disorders.Ms.
Kanika Malik. Guides: Dr. LN Suman, Dr. Prabath
K Chand, Dr. P Marimuthu
The aim of the study is to examine the clinical profile of
women with alcohol use disorders (AUDs). It also aims to
explore adverse life experiences, relational factors,self-image
and perceived social support among women with alcohol use
Annual Report
2013-14
disorders. The study will use both quantitative measures and
interview techniques to collect data. The sample will consist
of35womenwith aprimarydiagnosisofalcoholusedisorder.
Interviews with a family significant other will also be carried
out.Thefindingswillcontributetobetterunderstandingofthe
treatmentneedsofthispopulation.
in-depth interviews have been conducted with 14 long-term
volunteers,sofar,toaddressthestudyobjectives.
47. Personal growth: processes and determinants in
college youth. Ms. Anindita Bhattacharya.Guide:
Dr. Seema Mehrotra (Funding by UGC)
Thisstudyaimsatexploringsocialwell-being,itsmanifestations
anddimensionsfromtheperspectivesofyouthanddeveloping
abrieforientation-sensitizationprogramforenhancingyouth
engagement. The survey has yielded rich observations on
indicatorsofsocialwell-beinginyouthandthedimensionsof
socialwell-beingmostrelevantforurbanIndianyouth.Abrief
orientation-sensitizationprogramhasbeendevelopedbasedon
focusgroupdiscussionsandsurveys.Thisprogramiscurrently
beingpilottested.
Personal growth goal processes were examined in multiple
samples of 18-30 years old youth in college settings using
mixedmethods.Linkagesbetweenimplicittheoriesofchange,
possible selves, role of self as an agent and growth pursuit
processes were noted. Ameasure for assessment of personal
growthgoalwasdeveloped.Severaldifferenceswereobserved
between extreme scorers. The stages of change model had
limitedutilityinthiscontext.Contemplationandactioncame
upasthetwocoredimensionsofchange.Thefindingsprovide
leads for developing promotive programs to support young
adultsininternationalpursuitoftheirdevelopment
48. Positive mental health: Exploring salient
dimensions and developing an interview-based
assessment measure. Mr. Diptarup Chowdhury.
Guides: Dr. Seema Mehrotra, Dr. Ahalya Raguram
This is a multiphase study that aims at identifying relevant
dimensionsofpositivementalhealththroughatwo-stepDelphi
method, conducting in-depth interviews to understand the
livedexperiencesrelatedtovariousdimensionsthusidentified,
and subsequently developing and standardizing an interview
schedule for assessment of positive mental health. The study
is currently in its last phase of standardizing the interview
schedule.
49. Motives,patterns and psychological outcomes of
formal volunteering: An exploratory study.Mr.
Jereesh K Elias. Guides: Dr. Seema Mehrotra, Dr.
Paulomi Sudhir (Funding by ICSSR)
The major objectives of this study are to explore patterns of
formal volunteering, motives and other psychosocial factors
associated with the same in contemporary India as well to
documentexperiencesandmentalhealth/wellbeingoutcomes
linked to regular formal volunteering. It uses a prospective
mixedmethodsdesign.Datahavebeencollectedfrom83new/
prospectivevolunteerswhoarebeingfollowedup.Inaddition,
50. Social well-being in Indian youth. Mr. Rajeev
Jospeh Michael. Guides: Dr. Seema Mehrotra,
Dr. Srikala Bharath (Funding by CSIR)
51.
Integrated
neuro
and
social
cognitive
intervention program (INSCIP) for patients with
schizophrenia: A randomized controlled study.
Ms. Aarati Taksal. Guides: Dr. Paulomi M Sudhir,
Dr. Keshav Kumar J, Dr. Jagadisha
The study examined effectiveness of the Integrated
Psychological Therapy (IPT) in improving social functioning
inpatientswithschizophrenia.Sampleconsistedof29patients
with schizophrenia or schizoaffective disorder. A single
group design with baseline, post- follow-up assessment was
adopted. The IPT was modified for cultural appropriateness
and had 16-20 sessions of Cognitive Differentiation, Social
Perception,Verbal Communication, and Social Skills. Psycho
education was included for patients’ caregivers. RMANOVA
showed significant improvement on social cognition, social
skills, social functioning, symptom severity and some
neurocognitive functions. Medium to large effect sizes for
socialcognition,socialskills,socialfunctioningandsymptom
severity.
52. Attachment, interpersonal sensitivity and affect
regulation in social anxiety. Ms. Selvi Kumari
R. Guides: Dr. Paulomi M Sudhir, Dr. Seema
Mehrotra
The study examined the role of attachment, interpersonal
sensitivityandaffectregulationinsocialanxietywithasample
of360communityparticipants(intwosteps)and50patients
withadiagnosisofsocialphobia,usingamixedmethoddesign.
Assessment of the community sample was done in two steps.
Apreliminarymodelwasdevelopedandreplicatedinasecond
Annual Report
2013-14
sampleandsubsequentlyinaclinicalsample.Resultsindicate
significant differences in community and clinical samples.
Path analysis indicated that reappraisal, suppression and
ruminationmediatedtherelationshipbetweenattachmentand
social anxiety and interpersonal sensitivity and social anxiety
inallgroups.
53. Development and feasibility of a self-management
intervention in Type 2 diabetes mellitus. Ms.
Anisha Mary Abraham. Guides: Dr. Paulomi M
Sudhir, Dr. Ganapathi Bantwal
Thestudyaimedtoexplorefeltneedsofdiabetescareproviders,
patientsandsignificantothersofpatientswithdiabetesandto
developadiabetesself-managementinterventionandexamine
its feasibility and impact on improving self-care, metabolic
control and quality of life in patients with Type 2 Diabetes
Mellitus.Thirtyeightinterviewswerecarriedout,andanalyzed
inStudyI.Acopingskillsintervention,focusingonaddressing
self-care and emotional issues in diabetes was designed.
Eightypatientshavebeenrecruitedandrandomizedtoeither
intervention or treatment as usual group in Study II. Data
analysisandinterpretationareinprogress.
54. Efficacy of Metacognitive therapy in patients with
social anxiety disorder. Ms. Lakshmi J Guides:
Dr. Paulomi M Sudhir, Dr. Mahendra P Sharma,
Dr. Suresh Bada Math
ThestudyaimstoexaminetheefficacyofMetacognitivetherapyin
patientswithsocialphobia,usingacontrolgroupwhichwillreceive
AppliedRelaxation.Thetotalsamplewillbe50patientswhowillbe
assessedonmeasuresofMetacognition,socialanxiety,postevent
processinganddepression.Theywillreceiveapproximately10-12
sessionsoftherapyandwillbeassessedatpre,postandfollow-up
periods.Thepilotphaseofthestudyisinprogress.
55. Effectiveness of an integrated intervention
program for alcoholism (IIPA): To enhance
executive functions, affect regulation, and quality
of life. Mr. Rajesh Kumar. Guides: Dr. Keshav
Kumar J, Dr. Vivek Benegal, Dr. Roopesh BN,
(Funding by ICMR)
TheaimofthestudyistodevelopanIntegratedIntervention
Program to enhance executive functions through cognitive
remediation and affect regulation ability using Qigong
and Tai-chi Chuan practice. For base line and outcome
assessment behavioral scale, neuropsychological test and
electrophysiologicalmeasurewereincludedinthisstudy.Tools
whichrequiredtobedevelopedbytheresearcheraredeveloped
and10tasksforcognitiveremediationprogramalsodeveloped
by the researcher. Qigong and some moves of Tai-chi Chuan
which will be used in intervention is being practice by the
researcher. The pilot phase is initiated, after which the main
phasewillbestarted.
56. Development of an intervention programme
for socio-cognitive deficits in schizophrenia
spectrum disorders. Ms. Dhanya C. Guides: Dr.
Keshav Kumar, Dr. Jagadisha Thirthahalli
Socio-cognitivedeficitsformaninherentcontributionofmany
mental illnesses, and have been studied in autism spectrum
disorders,psychosesandpersonalitydisorders.Inschizophrenia
spectrumdisorders,psychotropicdrugshavebeensuccessfulin
eliminating most positive symptoms. However, their efficacy
inalteringsocio-cognitivedeficitsisnotproventilldate.This
implies that patients who are symptom-free and stable on
medications will be unable to lead functionally independent
lives,due to deficits in socio-cognitive processes. The current
researchaimstodevelopaholisticinterventionprogrammefor
socio-cognitivedeficitsfromaneuropsychologicalperspective,
andtestitsutilityinSchizophreniaSpectrumDisorders.
57.
Resilience based intervention in college students.
Ms. Hesi S Herbert. Guide: Dr. Manjula M
The aim was to examine the correlates of resilience and the
effect of resilience based intervention for college students.
In phase I, 200 college students were assessed and in the
phase II, 90 students received resilience-based intervention
in a workshop format. Results showed that the students
experienced high stress levels in academics and dealing with
financial and relationships issues. Half of the students had
mildlevelofdepression,stressandmoderatelevelofanxiety.
Positive emotion and conscientiousness predicted resilience
inpositivedirection.Interventionimprovedtheresilienceand
problemsolvingandreducedthenegativeemotionatthethird
monthfollow-up.
58. Emotion regulation therapy in anxiety disorders:
an outcome study. Dr. Vidhya Sagar K. Guides:
Dr. Manjula M, Dr. Mahendra P Sharma, Dr.
Suresh BM (Funding by ICMR- JRF)
The study aims to examine the efficacy of emotion regulation
therapy in anxiety disorders (GAD, SAD & PD) in improving
Annual Report
emotion regulation and reducing symptoms. In addition,
mediating role of Mindful awareness and Homework
complianceandroleofmoderatorssuchasanxietysensitivity
andtraitanxietyinoutcomewillbeexamined.Sampleconsists
of 60 participants (Intervention group 30 and Treatment as
usualgroup,30)withprimarydiagnosisofoneoftheanxiety
disordersincludedinthestudy.Interventiongroupwillreceive
16sessionsofemotionregulationtherapy.Bothgroupswillbe
assessedatpre,postandfollow-upperiods.
59. Cognitive styles, Psychosocial and clinical
determinants of functioning inpatients with
bipolar disorder. Ms. Mareena Susan Wesley.
Guides: Dr. M Manjula, Dr. Jagadisha T, (Funding
by ICMR-JRF)
The study aims to examine the cognitive styles, clinical and
psychosocial determinants of functioning and subjective
experiencesinpatientswithbipolardisorder.Asampleof150
patientsdiagnosedwithbipolardisorder,fulfillingtheinclusion
andexclusioncriteriawillbeselectedforthequantitativestudy
of which a sub-sample will be drawn for in-depth interviews
using a semi-structured interview format. A cross sectional,
mixedmethodexploratorydesignwillbeused.Thepilotphase
ofthestudyiscompletedwith26patientsfortheexploratory
study, and 2 patients have been interviewed using semistructuredinterviewforsubjectiveexperiences.
60. Efficacy of a school-based group coping skills
program for adolescents. Ms. Meghna Singhal.
Guides: Dr. M Manjula, Dr. K John Vijay Sagar
The present study is an endeavor to provide intervention to
adolescents with sub-clinical depression, in order to arrest
the growth of future psychopathology. The aim is to study
theefficacyofaschool-basedgroupcopingskillsprogramfor
adolescentswithsub-clinicaldepression.
Themainstudyhasbeencompleted:atotalof800students
across five schools have been screened. The 8-weekly
intervention has been carried out with students in index
group(n=49)andaninteractivepsycho-educatorysession
has been carried out with control group students (n=51).
Post-intervention and follow-up assessments have also
been carried out with all the students in the index and
control groups. Currently, statistical analysis is being
carriedout.
61.
Brief cognitive behavior therapy in remitted
bipolar disorder. Ms. Seema P Nambiar. Guides:
2013-14
Dr. M Manjula, Dr. Shyam Sundar A (Funding by
ICMR-JRF)
The study is being undertaken to examine the effect of brief
CBT on inter-episodic symptoms, dysfunctional cognitions,
adherencetotreatment,emotionalregulation,functioningand
qualityoflifeinremittedbipolardisorder.Agrouprandomized
control design with multiple assessments (pre, post & followup at 3 months) is planned. The sample would consist of 30
patientsintheinterventiongroupand30patientsintheTAU
(treatmentasusual)conditionintheage-rangeof18-55years.
Eight-10 individual sessions are being held on a weekly basis
for the study group and screened using the MINI, SCID-II,
YMRS&BDI-II.
62. Development and validation of an instrument for
the assessment of internet use in Indian context.
Mr. Thamilselvan P Guides: Dr. Manoj Kumar
Sharma, Dr. Prabha S Chandra, Dr. K Thennarasu
63. Ethical beliefs and practices in psychotherapy
and counselling: An exploratory study among
mental health practitioners and development of
a training module. Mr. Ananya Sinha. Guides:
Dr. Poornima Bhola, Dr. Ahalya Raguram, Dr.
Prabha S Chandra
The study aims to explore the ethical beliefs and practices
in psychotherapy and counselling among mental health
practitioners and develop a training module on ethics in
psychotherapy and counselling. A total of 265 participants,
practicing Clinical Psychologists, Psychiatrists, Psychiatric
Social Workers, Trainees from the three disciplines and
counsellors will be administered a survey schedule on ethical
beliefsandpractices.Asub-sampleof28participants,including
fourfromeachgroup,willbeselectedtoconductanin-depth
interview.
Basedonthefindingsofthesurveyandinterview,atrainingmodule
onethicsinpsychotherapyandcounselingwillbedeveloped.
64. Psychosocial aspects of children of female
sex workers. Mr. Siddharth Dutt. Guides: Dr.
Roopesh BN, Dr. Janardhana N
Inthisstudy,theinvestigatorswillexploreattachmentpattern,
resilience,risktakingbehaviour,parentingpractices,justworld
belief, attitude towards education and career and perceived
stigma in children of female sex workers. The child rearing
practicesamongsexworkerswillalsobeexplored.Attachment
Annual Report
2013-14
pattern, resilience, risk taking behaviour, parenting practices
andjustworldbeliefswillbecomparedwithchildrenofsingle
parentsandchildrenlivingwithboththeparents.
65. Felt obligation and separation-individuation
in offspring’s of individuals with severe mental
disorders. Ms. Seema Nambiar. Guide: Dr. Ahalya
Raguram
The study compared youth with and without parental
mental illness on the variables of felt obligation, separationindividuation and psychological distress, using a mixedmethods design. There was no significant difference in the
process of separation-individuation or level of psychological
distress between the two groups. Themes of felt obligation
included perceived difficulties in spending time with parents
andsatisfactionwiththesame.
66. Individuation in youth: The parental perspective.
Mr. Shiju Joseph. Guides: Dr. Ahalya Raguram
The study aimed to understand the perspective of
parents of youth regarding their children’s process of
individuation, using qualitative methodology. Analysis of
themes revealed that over-conforming youth and vigilant
parents formed a symbiotic pair which was based on the
knowledgeoftheyouth’slife.Parentspreferredtheiryouth
todevelop‘maturity’thatismarkedbyvalueorientation,
obedience, connectedness and behavioral independence
rather than individuation. Separateness, emotional
autonomyorvalueautonomywerenotencouraged.These
findingssuggestthatunfoldingofpsychologicalprocesses
like individuation is highly influenced by culture. This
also implies that achievement of separation would be a
challengeforyouth.
67. Exploring
attachment
relations:
Child’s
perspective. Ms. Divya V Salian. Guide: Dr. Uma
Hirisave
The aim of the study was to explore child’s perspective of
attachmentrelationsusingdifferenttypesofpsychologicaltests.
Asampleof30childrenintheagegroup6-8yearswasincluded.
Parental perception of child’s attachment was assessed by an
interview schedule. The results indicated that a majority of
childrenexpressedsecureattachmentwiththeirparentsacross
tests. The children expressed more positive feelings towards
their mothers and this finding was corroborated by parental
reports.
68. Exploring quality of life in children and
adolescents with epilepsy: A qualitative study.
Ms. Mallika Batra. Guides: Dr. Uma Hirisave, Dr.
Sanjib Sinha, Dr. PS Bindu
Theaimofthestudywastoexplorethequalityoflifeinchildren
and adolescents with epilepsy. The perspective of parents
wasalsolookedinto.Twentychildrenaged9to16yearswith
a diagnosis of epilepsy and their parents were interviewed.
Thematic analysis was used to arrive at prominent themes.
Theresultsindicatedifficultiesindomainsofphysical,social,
emotional,behavioral,cognitiveandacademics.Thequalityof
lifewasfoundtobepoorastheyhadexcessivetiredness,lack
ofautonomy,sadness,angerandacademicunderachievement.
Theirknowledgeofepilepsywasfoundtobeverylimited.
69. A qualitative study of communication in couple
therapy. Ms. Vaisnvy NM. Guide: Dr. Anisha Shah
A qualitative study of communication in couple therapy
was completed. It was designed to explore the process of
communication with couples in a clinical setting. Thematic
analysis using a priori codes for communication was used
for 34 conjoint couple session records. Results showed that
communication issues were a common presenting problem,
gender differences are present in communication issues in
couple therapy, and poor engagement between couples and
poordifferentiationfromfamiliesoforiginwereevidentinthe
couples.
70. Marital satisfaction in couples. Mr. Subhash
Chandra Singh. Guide: Dr. Anisha Shah
A study on marital satisfaction in couples is ongoing. The
aim of the study is to examine trait expressiveness, partner
responsiveness, need satisfaction and marital satisfaction in
married persons. Forty married persons including 12 couples
comprisedthestudysample.PersonalAttributeQuestionnaire,
Partner Responsiveness Scale, Basic Needs Satisfaction in
RelationshipsScale,RelationshipAssessmentScale,andScale
ofPositiveandNegativeExperiencewereadministeredtothe
participants.Pearson’sProductMomentCorrelation,t-testand
Mann-Whitney Test showed significant correlations among
the study variables, no gender differences but significant
differences on study variables when comparisons were made
onthebasisofageandmaritalduration.
71.
Eating disorder, body image concerns and selfesteem among college students: A survey. Ms.
Annual Report
Rinsha EK. Guides: Dr. Mahendra P Sharma, Dr.
Prabha S Chandra
The study aimed at exploring eating disorder, body image
concerns and self-esteem among 299 college students. The
resultsrevealedthateatingdisordersymptomsandbodyimage
concernswerepresentinIndiancollegestudents.OnEAT-26,
13%scoredabovecutoffandonBITE,27%werefoundtohave
disordered eating pattern and 1% was found to have highly
disordered eating pattern. Disordered eating and body image
concernswerepositivelycorrelated.Disorderedeatingandbody
image concerns were negatively correlated with self-esteem.
Therewerenosignificantdifferencefoundbetweenmalesand
females on disordered eating symptoms, body image concern
andself-esteembutsymptomseveritywasmoreinmalesthan
infemales.Weightreductionattemptswerereportedby31%of
students.
72.
Beliefs, psychological impact and quality of life
in men with sexual dysfunction. Mr. Sujith Babu.
Guides: Dr. Mahendra P Sharma, Dr. Nagaraja Rao
The aim of the present investigation was to study the beliefs,
psychological impact and quality of life in men with sexual
dysfunction. The sample consisted of 25 men with sexual
dysfunctionand25normalcontrols.Theresultsrevealedthat
men with sexual dysfunction have negative stereotypes about
sexuality,poorersexualknowledgeandmoreconservativesexual
attitudes in comparison to normal controls. Men with sexual
dysfunctionexperiencehigherlevels ofanxietyanddepression,
andsexualdysfunctionhavenegativepsychologicalimpactand
adverselyaffectqualityoflife.Someofthestereotypedbeliefs
werenegativelycorrelatedwithsomedomainsofqualityoflife.
73.
Stress and coping among family members of men
with substance dependence. Ms. Shynimol KB.
Guides: Dr. LN Suman, Dr. Prabath K Chand
Theaimofthepresentstudywastoexaminestressanddistress
amongfamilymembersofmenwithsubstancedependence.The
sampleconsistedof60familymembers:30familymembersof
maledrugdependentsand30familymembersofmalealcohol
dependents.ThefamilymemberswereadministeredtheCoping
Questionnaire,FamilyMemberImpactQuestionnaire,Symptom
RatingTestandtheHopefulness-HopelessnessQuestionnaire.
Findings indicated that the family members of both groups
wereequallystressedandexperiencedsignificantdistressdue
tothepatients’dependenceonsubstances.Thesefactorshave
tobeaddressedwhileplanningfamilyfocusedinterventions.
74.
2013-14
Smoking motives, perceived consequences and
motivation to quit among men with common mental
disorders. Ms. Arathy VS. Guide: Dr. LN Suman
Theaimofthestudyistoexaminesmokingmotives,perceived
consequencesandmotivationtoquitamongmenwithcommon
mentaldisorders.Thesamplewillconsistoftwogroups.GroupI
willconsistof30malesmokerswithcommonmentaldisorders
andGroupIIwillconsistof30malesmokerswithoutcommon
mental disorders. Data will be obtained from K6 Screening
scale, Fagerstrom Test for Nicotine Dependence, Wisconsin
Inventory of Smoking Dependence Motives, Smoking Effects
Questionnaire, Knowledge of Health Effects and Stages-ofChangeQuestionnaire.
75.
Stress, wellbeing and self-care practices in
mental health trainees. Ms. Lyn G. Guides: Dr.
Seema Mehrotra, Dr. Thirumurthy
Stress,self-care,andwellbeingin58mentalhealthtraineesin
ClinicalPsychologyandPsychiatricSocialworkwereexplored
throughatwo-pointsurveyspacedthreemonthsapart.Average
levelsofperceivedstressandnegativeeffectswerehigher,while
positive effects, life satisfaction and psychological wellbeing
were lower than in other Indian youth studies. There was
significant decline in psychological wellbeing over the study
period.Lowengagementinself-caredomainswasobservedin
asignificantproportionofthesample,self-careatTime1was
significantlycorrelatedwithallthewellbeingindicesatTime2.
76.
Interactions with mental health service providers:
Caregiver perspectives. Mr. Dinakaran P. Guides:
Dr. Seema Mehrotra, Dr. Srikala Bharath
The study explored the importance of various interactional
aspectsofmentalhealthcareduringpsychiatrichospitalization
from the perspectives of 50 family caregivers between 1879 years of age range. Six domains of interactional aspects
of care were identified: Dignity, confidentiality and fairness,
informational inputs, addressing of concerns raised, prompt
attention and consistent care, autonomy and collaboration,
and demonstration of general support. Significant differences
emergedontheperceivedimportanceofthefirstfourdomains
ofcarebetweensubgroupsofcaregiversbasedoneducational
level,socioeconomicstatus,thepatients’hospitalizationhistory
andbroaddiagnosticgroups.
77.
Perfectionism, rumination and negative affect
in patients with social phobia. Ms. Rukmini S.
Annual Report
2013-14
Guides: Dr. Paulomi M Sudhir, Dr. Suresh Bada
Math
resultssuggestthepresenceofaspecificcognitiveprofileand
itsrelationtoreductionofqualityoflife.
The study examined the relationship between perfectionism,
rumination, emotion regulation strategies of positive
reappraisalandacceptanceandnegativeaffectinpatientswith
socialphobia.Sampleincluded30patientswithsocialphobia
and 30 community participants. Results showed the patients
with social phobia had elevated levels of perfectionism and
rumination, both reflection and brooding and had lesser use
of positive reappraisal strategy than a community sample.
Rumination was associated with maladaptive perfectionism
and overall perfectionism. Personal standards and parental
expectations were positively correlated with positive
reappraisal. Parental criticism was a significant predictor of
socialphobiaandbroodingsignificantlypredicteddepression.
80. Neuropsychological, social
and
emotional
correlates of traumatic brain injury. Ms. Fasli
Sidheek. Guides: Dr. Keshav Kumar J, Dr. Jagath
Lal
78. Perfectionism, procrastination, coping and
psychological outcomes. Ms. Athulya Jayakumar.
Guide: Dr. Paulomi M Sudhir
The study aimed at examining neuropsychological, social
cognitive and emotional correlates of people with Traumatic
Brain Injury (TBI) and their association with impulsivity.
The sample consisted of 20 patients. The results showed that
patients with TBI had significant deficits in social cognition
along with neurocognitive deficits, second order theory of
mind, identifying faux pas and social perception. On tasks of
emotion perception, deficits were not prominent though they
haddifficulties.Theimplicationsandstrengthsofthestudyas
wellaslimitationshavebeendiscussed,withrespecttofindings
andrelevantliterature.
81.
The study examined perfectionism, procrastination, coping
styles, psychological outcomes of self-esteem, mood in young
adults.Sampleconsistedof192collegestudents,between1826years.Procrastinationandpsychologicaldistresswerehigh
in the sample. Female participants reported higher parental
expectations and avoidant coping than males. There was a
significant negative relationship between procrastination and
the adaptive perfectionism dimension. Adaptive dimensions
of perfectionism were associated with lower distress as
compared to maladaptive dimension. Higher procrastination
was associated with lower experience of self-esteem, greater
depression, anxiety and stress. Maladaptive perfectionism
predictedgreaterdistress,andadaptiveperfectionismpredicted
higherself-esteem.
79. Neuropsychological profile in patients with
juvenile myoclonic epilepsy. Mr. Mohd. Afsar.
Guides: Dr. Keshav Kumar J, Dr. Sanjib Sinha
Thestudyaimedatexaminingtheneuropsychologicalprofile,
andqualityoflifeinpatientswithJME(n=20)andgender,age,
education,matchedhealthycontrolsintheage16to45years.
The results revealed that JME patients have impairment in
attention, visual search, mental flexibility, word reading and
visual memory compared to controls. There was significant
correlation between attention, visual working memory
and verbal memory and quality of life. There was negative
correlationbetweenimpulsivityandoverallqualityoflife.The
Emotion regulation, attachment styles and
psychological problems among college students.
Ms. Lavanya TP. Guide: Dr. M Manjula
The aim was to examine emotion regulation, attachment
styles and psychological problems among college students.
Thesampleconsistedof419students,studyingpre-university
and graduation respectively. The results indicated that,
predominantlypositiveemotionregulationstrategies(refocus
onplanningandpositivereappraisal)wereused;especiallyby
studentsinpre-universitygroup.Majorityofthestudentshad
secure and avoidant attachment styles. Affective/depressive
and conduct problems were reported more by the students.
Students in undergraduate group had comparatively more
psychological problems. Significant correlations between
emotion regulation, attachment styles and psychological
problemswerefound.Femaleshadmoreofanxietyproblems
andmaleshadconduct/antisocialproblems.
82. Sexual attitude, knowledge, behaviour and
sources of influence in youth. Mr. Siddarth Dutt.
Guides: Dr. M Manjula
The aim of this study was to explore sexual knowledge,
attitude,behaviourandthesourcesofinfluenceinyouth.The
studywasdoneintwophases.Inthefirstphase,thescalefor
assessing sexual behaviours, and Sources of Influence (SBSI)
wasdeveloped.Inthesecondphase,theSexualKnowledgeand
Attitude Questionnaire were used to assess sexual knowledge
Annual Report
and attitude. The questionnaires were administered to 300
collegestudents.Theresultsshowedtheyouthhadpoorsexual
knowledge—there was a positive relationship between sexual
knowledgeandattitude.Internetwasfoundtobethemajorand
reliablesourceforgatheringinformation.
83. Self-injurious behaviours, attachment styles and
emotion regulation among college students. Ms.
Naphisabet Kharsati. Guide: Dr. Poornima Bhola
Thestudyexaminedself-injuriousbehaviours(SIB)among470
undergraduateandpost-graduatecollegestudentsandexplored
associations between SIB, attachment styles and emotion
regulation.Resultsindicatedthat31.2%reportedSIB(pastyear),
with19.4%engaginginmoresevereformsofSIB.Meanageof
onset was 15.86 years, with more males engaging in SIB. The
majority did not report any suicidal intent, engaged in the act
impulsivelyandfeltlittleaccompanyingpain.SIBservedtoalter
emotionalstates,influenceothersorescapefrominterpersonal
demands. Higher levels of anxious attachment and emotion
regulationdifficultieswerereportedbyyouthengaginginSIB.
84. Autobiographical
memory
narratives
of
clients with borderline personality disorder in
psychotherapy. Ms. Deepti Guruprasad, Guide:
Dr. Poornima Bhola
A mixed-method case study design explored autobiographical
memory narratives in individual psychotherapy of five clients
with borderline personality disorder. Questionnaires assessed
working alliance, emotion regulation and attachment styles.
Session transcripts of the biopsychosocial interview and five
therapysessionswerecodedandqualitativelyanalysed.Results
indicated emotion regulation difficulties,varied insecure
attachmentstylesandindividualpatternsofclientandtherapist
ratedalliance.Narrativeshadmoderatelevelofcomplexity,were
predominantly autobiographical, with low specificity, largely
non-integrated and reflecting themes of contamination (with
relativelylowerthemesofagency,communionandredemption).
Affective scripts revealed early traumatic experiences
contributingtonegativeeffectandinterpersonaldistress.
85. Social cognition and attachment among
individuals with emotionally unstable personality
disorder. Ms. Anupama V. Guides: Dr. Poornima
Bhola, Dr. Jagadisha Thirthalli
Thestudyaimedatexaminingattachment,mentalizationand
social cognition, in individuals diagnosed with Emotionally
2013-14
Unstable Personality Disorder (EUPD). The study was
conducted on the clinical group (N=20) and control group
(N=20)aged18-50years.ThetoolsincludedAttachmentStyle
Questionnaire,MentalizationQuestionnaire,ReadingtheMind
in the Eyes Test, and Social Cognition Rating Tool in Indian
Setting (SOCRATIS). The results indicated that individuals
diagnosedwithEUPDhadsignificantlyhigherscoresonanxious
attachment,preoccupiedattachment,lowermentalizingability,
lowerfacialemotionrecognitionabilityandselectdomainsof
socialcognition.
86. Marital relationship, distress and resilience in
women with primary infertility. Ms. Sisira C.
Guide: Dr. Veena Satyanarayana
Thepresentstudyexploredthequalityofmaritalrelationship,
psychological distress and resilience among women with
primaryinfertility.Thesamplecomprisedof30adultwomen
diagnosed with primary infertility- female factor by the
consultant gynecologist at a renowned infertility hospital
in Bangalore. The study was cross-sectional in nature and
employed a single group mixed methods design. Findings
indicated that women who experienced violence were more
likely to report lower quality of marital relationship, higher
levels of distress, and lower resilience. Experience of at least
one form of violence emerged as a significant predictor of
distressexplaining36%oftotalvariance.
87. Evaluation of musical rhythm discrimination
ability in patients with Parkinson’s disease. Ms.
Amrita Biswas. Guides: Dr. Shantala Hegde, Dr.
Pramod Kumar Pal
The present study assessed musical rhythm discrimination
abilityinpatientswithParkinson’sdisease(PD)andexamined
therelationshipbetweenneurocognitivefunctionsandmusical
rhythm discrimination ability. The sample consisted of PD
group(n=21)andage,genderandeducationmatchedhealthy
volunteers (HC) (n=21). The patients and participants were
assessed with a set of neurocognitive measures to examine
working memory, attention and immediate memory. The
musical rhythm discrimination ability was assessed by using
seashore rhythm test, auditory rhythm test, beat alignment
test,andtwosub-testsoftheMontrealbatteryofevaluationof
amusia(MBEA)—rhythmiccontourandmetrictest.Thestudy
wascarriedoutinasound-treatedroomandtherhythmtests
were presented via windows media player using 2.1 speakers.
TheresultsshowedsignificantdifferencebetweenPDandthe
HCgroupsonalltheneurocognitive(p<0.001)andmusical
Annual Report
2013-14
rhythm measures (p < 0.001). There was significant positive
correlation between neurocognitive measures and musical
rhythmperception(p<0.001).Thepresentstudyisthefirstof
its kind examining various dimensions of rhythm perception
including stimuli that were musically based and not just
metronomebased.Thefindingsthrownewlightonimpairment
intemporalprocessingatdifferentlevelsinPDandindicatethe
stronginter-connectionbetweenprefrontalareasandthebasal
gangliainthiscognitiveprocess,worthexaminingusingother
methodsinfutureresearch.
The aim of the study is to examine defensive pessimism,
perceivedstress,copingandpsychologicalfunctioninginyouth,
relationshipamongthesevariablesaswellasgenderdifferences
indefensivepessimism.Thesamplewillcomprise300students
pursuing their graduation studies from Bangalore, in the age
range of 18-24 years. The tools used for the study are sociodemographic data sheet, defensive pessimism questionnaire,
proactivecopinginventory,Rosenbergself-esteemscale,youth
self-reportandperceivedstressscale.
91.
88. Just world belief and executive functioning in
children with conduct disorder. Ms. Prateeksha
S. Guides: Dr. Roopesh BN, Dr. John Vijayasagar
Prosocial behavior and executive functions in
children and adolescents with conduct disorder.
Ms. Lalhmingmawii. Guides: Dr. Roopesh BN,
Dr. John Vijayasagar
The aim of the study was to examine Just World Belief in
children with conduct disorder in comparison with Typically
Developing Children. Each group comprised of 13 children,
aged11-15years.TheywereadministeredtheJustWorldBelief
Scale(JWBS)andExecutiveFunctions(EF)tests.Theresults
revealed that both the groups significantly differed in their
BeliefaboutUnjustWorldforOthers.InEF,significantgroup
differenceswerenotedinallthecomponentsofStroopWord–
time,suchasNeutralWord–time,EmotionalWord–time,and
MoralWord–time.Analysisofresponsesonthecasevignettes
revealedthattheCDgroupplacedresponsibilityontheperson
and not on the victim and opted for retribution rather than
compensationofthe victim.
The aim of the study is to examine Prosocial Behavior in
children with Conduct Disorder in comparison with Typically
DevelopingChildren.Thesamplewillconsistoftwogroups—
children with Conduct Disorder and Typically Developing
Children. Each group will comprise 15 children, aged 8-16
years.ThesechildrenwillbeassessedintermsoftheirProsocial
Behavior and Executive Functions. They will be administered
theProsocialBehaviorScale(PSBS),whichwasdevelopedfor
thepurposeofthestudy,CaseVignettesforassessingProsocial
Behavior,ExecutiveFunctionstestslikeWisconsinTypeCard
Sorting Test (WCST), Tower of London (TOL), Corsi Block
SpanTest,WordStroopTest,PictureStroopTest,StopSignal
Test,VerbalFluencyTestandDigitSpanTest.
89. Insight and decision making in children with
conduct disorder. Ms. Anjali S. Guides: Dr.
Roopesh BN, Dr. John Vijayasagar
92. Assessment of value of life and executive functions
in children with conduct disorder. Ms. Meghana
V. Guides: Dr. Roopesh BN, Dr. John Vijayasagar
The present study explored the relationship between insight
and decision making in children with conduct disorder.
Sample consisted of two groups of 12 children with conduct
disorder and 12 matched typically developing children.
Children with conduct disorder were administered Insight
Scale and Conduct Disorder Rating Scale. Both the groups
wereadministeredRealGamblingTask,SamplingShiftTask,
DelayDiscountingTask,RPMwereadministered.Theresults
showedthat,comparedtotheTypicallyDevelopingChildren,
CD children showed deficits in delaying their gratification,
made impulsive choices without exploring the options and
ignored the feedback. There was no significant relationship
betweeninsightanddecisionmaking.
TheaimofthestudyistoexaminetheValueofLifeandexecutive
functionsinchildrenwithconductdisorder,incomparisonwith
typically developing children. The sample would comprise two
groups,15ineach;onegroupconsistingofchildrenwithconduct
disordersandanotherconsistingofTypicallyDevelopingChildren.
ThechildrenwillbeassessedonValueofLifeparameters,CPM,
DBRS, SDQ, Delay Discounting Task, Modified Information
Samplingtask,DigitSpanandPictureStroopTest.
90. Defensive pessimism, coping and psychological
functioning in youth. Ms. Asha Ravi. Guide: Dr.
M Manjula
93. Effectiveness
of
neurofeedback
training:
clinical, cognitive, electrophysiological and
neurochemical measures in alcohol dependence
syndrome. Ms. Reji Mohan. Guides: Dr. Jamuna
R, Dr. Nandakumar DN, Dr. Pratima Murthy
Addiction is a primary, chronic disease of brain reward,
motivation,memoryandrelatedcircuitry.Dysfunctioninthese
Annual Report
circuits leads to characteristic biological, psychological, social
and spiritual manifestations. This is reflected in the individual
pursuingreliefbysubstanceuse.Theaddictioncaninvolvecycles
ofrelapseandremission.Withouttreatmentorengagementin
recovery activities, addiction is progressive and can result in
disabilityorprematuredeath.Thisstudywasaimedattheeffect
ofEEGNeurofeedbacktrainingonclinical,electrophysiological
andneurochemicalparametersinalcoholdependence.
This is a representative statewide survey to generalize health
problemsamongtheyouth(10-24years)inHimachalPradesh.
Thesurveyisongoing,and1600interviewswerecompletedout
ofthe2500required,ason31stMarch2014.
4.
Epidemiology
1.
Monitoring and evaluation of road safety–10 India
project. Investigator: Dr. Gururaj G (Funding by
Johns Hopkins University, USA)
Withroadtrafficinjuriesbecomingaleadinghealthproblemin
India, World Health Organization and the Ministry of Health
andFamilyWelfareinitiatedtheRoadSafetyProjectintheState
of Andhra Pradesh at Hyderabad and Vizag during 2011. The
projectaimsatimplementinganintegratedprogrammewitha
focusontworiskfactors,namelyhelmetuseanddrinkingand
driving. The Department provides monitoring and evaluation
technical support for data collection undertaken by IIPH –
Hyderabad through road side surveys, road side interviews,
secondary data, focused group discussions with key stake
holdersandin-depthinterviews.Fourroundsofdatacollection
havebeencompleted.
2.
Development of population based rural stroke
registry in India. Investigator: Dr. Gururaj G
(Funding by ICMR, New Delhi)
Good quality epidemiological data forms the backbone for
developing preventive, promotive, curative and rehabilitation
servicesforpatientswithstroke.Intheabovementionedproject,
a rural population based stroke registry has been developed
in collaboration with Community Medicine Department of
MSRamaiahMedicalInstitutioninChintamanitalukandthe
feasibilitystudyhasbeencompleted.Theresultsindicatethat
it is possible to establish stroke registry in rural areas using
existing health care functionaries in defined populations. The
Stoke registry aims at understanding prevalence, incidence,
mortality, disability, and risk factors of stroke in a taluk
populationandthevalidationstudyarecurrentlyinprogress.
3.
Adolescent and youth health survey at Himachal
Pradesh. Investigators: Dr. G Gururaj, Dr.
Pradeep BS (Funding by National Rural Health
Mission – Himachal Pradesh)
2013-14
The burden attributable to headache disorders
in the general population of India Phase I: A
community based survey in Karnataka State.
Investigators: Dr. Gururaj, Dr. Girish N, Dr.
Girish B Kulkarni, Dr. Kavita R, Dr. Subbakrishna
DK (Funding by Global Campaign)
Headachedisordersconstituteamajorgroupinthespectrum
ofNeurologicaldisorders.Theabovecommunity-basedproject
aims to estimate the prevalence of various types of headache
and health seeking behaviors, and compare the quality of life
amongstthosewithheadacheandwithoutheadache,inurban
andruralareasofKarnataka.Atotalof2329individualswere
interviewed. The period and point prevalence was 63.9% and
10%, respectively, with greater burden in rural areas (71.2%
and 57.3% respectively). The methodology paper has been
completedandhasbeenpublishedintheJournalofHeadache
andPain.
5.
National mental health survey, Kolar pilot
study. Investigator: Dr. Gururaj G, (Funding by
MH&FW)
Mental, neurological and substance use disorders (MNS) are
increasinginIndia.ThenumberofIndiansaffectedwithMNS
disorders is not clearly known and the available estimates are
basedondatathatismorethantwodecadesold.Thenational
survey proposes to estimate true burden of mental health
problemsinarepresentativepopulationandprovideaframework
forevaluatingtheimpactofDMHP.Theobjectivesofthepilot
study in Kolar district are to understand the feasibility of the
samplingdesignadoptedfortheNationalMentalHealthSurvey,
identify challenges and operational feasibility of the proposed
study methodology including the use of MINI instrument. It
wouldprovideestimatesofprevalenceofdifferentmentalhealth
problemsinthedistrictofKolarandalsoregardingfeasibilityof
usingahandhelddevicefordatacollection.
6.
Analysis of highway crashes and determinants
in Kolar district. Investigator: Dr. G Gururaj
(Funding by Road Traffic Injury Network (RTIN)
Highway road crashes contribute for 40% road deaths and
injuries in India.Traumatic brain Injury in the crashes is the
commonest type of injury. However, the burden, pattern and
Annual Report
2013-14
characteristicsofroadcrashesonNationalandStatehighways
arenotknownduetolackofresearch.WithsupportfromRoad
Traffic Injury Research Network, the present project aims at
delineatingriskfactorsamonghighwaycrashes.
7.
The burden attributable to headache disorders in
the general population of India Phase 2: Cochrane
systematic reviews. Investigators: Dr. Girish
N, Dr. Girish B Kulkarni, Dr. Gururaj G, Dr.
Thennarasu K (Funding by Lifting the Burden)
Tension Type Headache (TTH) is a common but neglected
problem. Despite the huge burden, the WHO Essential drug
listdoesnotcontainthetreatmentguidelinesformanagement
of TTH. Hence, two Cochrane systematic reviews are being
undertaken: Paracetamol (acetaminophen) for acute episodic
tension-typeheadacheinadultsandAspirinforacuteepisodic
tension-typeheadacheinadults.Protocolshavebeenpublished
intheCochranelibraryandstudyisunderprogress.
8.
Developing and implementing an integrated
mental health promotion services for youth
through a district empowerment model in
Karnataka – Youth policy 2012 initiative.
Investigators: Dr. G Gururaj, Dr. Pradeep BS,
Dr. Seema Mehrotra (Funding by Department of
Youth Empowerment and Sports)
costs. To obtain a pan-India perspective, qualitative studies
have been undertaken in Mangalore and Bellary in Karnataka,
Puducherry, Thiruvananthapuram, Uttarakhand, Shimla and
Ludhiana. The final study report has been submitted to the
GovernmentofIndia.Datasetsarebeingeditedandcleaned.
10.
Iodine deficiency disorders–resurvey in Kolar.
Investigator: Dr. Girish N (Funding by IDD Cell,
Govt. of Karnataka)
Iodine Deficiency Disorders (IDD) is a preventable cause
of Intelligent Deficiency and is considered a public health
problem.UnderthenationalprogrammeforIDD,UniversalSalt
IodizationhasbeenthevehicleforcontrolofIDDcoupledwith
periodic monitoring of Goitre rates among schoolchildren—
measuringmeanUrinaryIodineIntakeandestimatinglevelof
Iodine in household salt samples have been undertaken. The
Centre for Public Health undertook the resurvey in Kolar. A
totalof4500childrenwereexaminedforGoitrefromrandomly
selectedschoolsacrossKolardistrictusingthemodifiedcluster
samplingtechnique.Inaddition,nearly1000saltsamplesand
325 urine samples were collected for analysis. Currently, the
saltsampleanalysisisbeingdone.
This project aims to develop a comprehensive mental health
promotionservices(includingcounseling)foryouthandtheir
parents in the state of Karnataka and implement the same in
theproposedYouthEmpowermentCentersindifferentdistricts
ofthestate.Thisprojectwillinitiallybedonein10districtsin
Karnataka with Kolar and Chikkaballapur districts being the
demonstrationdistrictsforthiswholeproject.
9.
Patterns and consequences of alcohol misuse in
India – A 5 region study. Investigators: Dr. Vivek
Benegal, Dr. Girish N, Dr. Gurruaj G, Dr. Pratima
Murthy, Dr. Prabhat Chand (Funding by WHO
India Country Office)
Children with Goitre (top). Children being examined in the school (bottom)
11.
Alcohol use is common across India. Prevalence estimates
indicate a huge burden: nearly one-third of adult males and
about5%ofadultfemalesconsumealcohol.A5-centrestudyis
currentlybeingimplementedin5regions(Dhule-Maharashtra,
Vishakpatnam-AndhraPradesh,Surat-Gujarat,Cuttack-Odisha
and Sikkim) where information pertaining to alcohol use is
scarce.Thekeyobjectivesofthestudyaretostudytheprevalence
andpatternsofalcoholuseandestimatetheindividualandsocial
Household burden of severe psychiatric
conditions a study from India, a developing
country. Investigators: Dr. Srikala Bharath Dr.
Girish N (Funding by Sanofi Venties)
Amajorconsequenceoftheepidemiologicalanddemographic
transitionis the increased need forhealth care of the elderly.
The Dementia India Report 2012 estimated that the average
costsofcareformanagingapersonwithdementiainIndiais
Annual Report
about INR 43,000. However, this cost is unrealistic keeping
in mind the burden of the disease and need for care. Hence,
the study, household burden of severe psychiatric conditions
including schizophrenia, depression, dementia and bi-polar
disorderisbeingundertaken. Datacollectionanddataanalysis
hasbeencompletedandreportisunderdevelopment.
12.
Patient satisfaction survey at NIMHANS.
Investigators: Dr. Girish N, Dr. Gururaj G, Dr.
Sateesh V
13.
Assessment of perceived needs and barriers for
care among patients with Stroke and unipolar
depression. Investigators: Dr. Gautham MS, Dr.
Girish B Kulkarni, Dr. Santosh Loganathan, Dr.
Gururaj G (Funding by NIMHANS)
Evidence regarding type of perceived needs and barriers
experienced by patients with stroke and depression will be
usefultobridgetreatmentgap,improvediseaseoutcomesand
enhancequalityoflife.Hence,ahospitalbasedcrosssectional
studywithacommunity-tracingsubcomponent,isconducted
to assess the perceived needs and barriers for care among a
convenientsampleofpatientswithstrokeanddepression.The
studywillhelpinneedbasedre-organizationofservicedelivery
andshortentreatmentgap.
14.
Community follow-up study of Parkinsonism
patients seen at NIMHANS. Investigators: Dr. Vivek
Gupta, Dr. G Gururaj, Dr. Pramod Pal, Dr. Ravi
Yadav (Funding by NIMHANS Intramural Grant)
Parkinsonism is among major causes of disability especially in
thegeriatricagegroup.WhiletheepidemiologyofParkinsonism
in India has been studied in terms of its prevalence and risk
factors,literatureonhealthseekingpatternsofpatients,disease
progressionandmortalityamongpatientsandtheburdenamong
caregivers of patients is unfortunately lacking. Accordingly, a
follow-upstudyofpatientswithParkinsonismseenatNIMHANS
OPDisbeingconductedadoptingacommunity-basedlongitudinal
follow-up design, to study the patterns and motivations for
health seeking among these patients. Simultaneously the
survivalpatternsandcaregiverburdenwillbeanalyzed.Results
ofthestudywouldenableinformedprogrammaticdecisionsfor
managingthesedisordersbetterbyprovidingdataonneedsofnot
onlythepatientsbutalsotheircaregivers.
15.
Stigma experience and related barriers of helpseeking in psychosis, depressive disorders
2013-14
and alcohol use disorders: A hospital based
exploratory study. Investigators: Dr. Senthil
Amudhan R, Dr. Girish N, Dr. Santosh
Loganathan, Dr. Arun K (Funding by NIMHANS)
Stigma associated with mental illness acts as a significant
barrier to access mental health care. In India, the research
relatedtomentalhealthstigmaisverylimited.Thisstudyaims
to generate evidence on stigma and related barriers of help
seekingamongschizophrenia,depressivedisordersandalcohol
use disorders in a sample of patients and their care givers
attendingtheOPDservicesofNIMHANS,throughquantitative
and qualitative approach. The study will provide evidence
for strengthening the public health approach in overcoming
the stigma and related barriers to improve the mental health
servicesutilization.
16.
Pilot study on youth mental health behavior
survey in Bangalore: Phase 1-Development of
methodology and questionnaire validation.
Investigators: Dr. Sunitha Singh, Dr. Gururaj G
(NIMHANS Intramural funding)
The project is initiated with an objective to develop and
validate appropriate and culture specific study instrument(s)
tounderstandandquantifymentalhealthbehaviorsincluding
substance use disorders and injuries among youth aged 16 to
30 years in Bangalore adopting quantitative and qualitative
research methodologies on a sample of 1900 youths from
educational institutions, workplaces and slums coming under
BBMPwards.Theoutcomesofthestudyincludevalidationof
studyinstrumentandgeneratingevidenceonperceptionsand
patternsofmentaldisordersincludingsubstanceusedisorders
andinjuriesamongyouthandstakeholders.
17.
Impact of a school based health education
program for epilepsy awareness among teachers
and school children. Investigator: Dr. Meena KS,
Dr. Vivek Gupta (Funding by NIMHANS)
Epilepsy is one of the most common neurological disorders
thataffectapproximately70millionpeopleworldwide,affects
childrentoagreatextent.Schoolteachersusuallydonothave
any formal instructions on epilepsy during their training. An
operational feasibility health education program is being
carried out for educating the teachers and schoolchildren,
whichwouldalsoassessthetrainingoftrainers’methodologyin
School-basedhealtheducationprogramonepilepsyawareness
forteachersandstudents.
Annual Report
2013-14
Human Genetics
1.
Expression and regulation of p16 and Bmi1 genes
in human glioma progression. Investigators: Dr.
Chetan GK, Dr. Dhananjaya I Bhat (Funding by
SERB, DST)
Glioma,abroadcategoryofbraintumorsthatcomefromglial
cells,arethemostcommonprimarymalignantneoplasmsofthe
centralnervoussystem.Somanymutationsoccurfrequentlyin
genesthatcontrolcellcycleandproliferationleadingtotumor
progression. The understanding of the role of bmi1 and p16
tumorsuppressorgeneindiagnosisofglioma,especiallyatthe
transcriptionallevelisininfantstage.Genealterationstudies
of both genes will be helpful for diagnostic and therapeutic
purposes.Mainalterationsinp16geneincludemutationsand
transcriptional regulations and deletions in one of the exons.
Aberrantmethylationofp16ingeneinserumcanbeanearly
diagnostic tool in glioma. Analysis of p16 SNPs in Indian
population may help to develop personalized medicine. Bmi1
geneamplificationandtranscriptionalandposttranscriptional
modification will be useful in prognosis of glioma. In this
project,weareconsideringthecorrelationofalterationsinboth
geneswiththeclinicaldata.Sothesegenescanbeconsideredas
goodprognosticanddiagnosticmarkersingliomaespeciallyin
theIndianpopulation.
2.
Genetic and expression studies of HLA-G and
cytokines to evaluate the immune-mediated risk
of schizophrenia. Investigators: Dr. Monojit
Debnath, Dr. Ganesan Venkatasubramanian
(Funding by NIMHANS)
Multiple lines of evidence have implicated dysregulated
immune processes in the pathogenesis of schizophrenia.
HLA-G plays a pivotal role in the outcomes of pregnancy.
AlteredexpressionofHLA-Gduetoenvironmentalandgenetic
variations lead to pregnancy complications, some of which
confer risk for schizophrenia. The 14bp insertion/deletion
(INDEL)polymorphismlocatedwithinthe3´UTRregionofthe
HLA-GlocusinChr.6p21.3isassociatedwithHLA-Gexpression
and function. Analysis of the role of 14bp polymorphism(151
patients and 113 healthy controls) and the impact of fetomaternal compatibility/incompatibility (64 mother-patient
duos)atthislocusontheriskofschizophreniawasstudied.In
addition,theeffectof14bpINDELonbrainstructurealterations
inschizophreniapatients(76patientsand108healthycontrols)
was also investigated. A significant increase of heterozygous
(+14bp/-14bp) genotype was observed in the female patients
(p≤0.05). Interestingly, mother and the female patients also
sharedincreased+14bp/-14bpcompatibility.Imaginganalysis
indicatedthatpatientsexhibiting+14bp/-14bpgenotypeshad
significantly deficient volume in the right hippocampus and
rightparahippocampalgyrus.
This study demonstrates a possible role of HLA-G in the
pathogeneticpathwayofschizophrenia.Takentogether,these
findingssuggest HLA-Gcould be animportant biomarkerfor
schizophrenia.
3.
The
Immuno-psychiatry
in
South
India
study (IPS)-Immunogenetic and immunophenotype characterization of major psychoses.
Investigators: Prof. Vir Singh Negi, JIPMER,
Prof. MA Vijayalakshmi, VIT, Dr. Monojit
Debnath (Funding by Indo-French Centre for the
Promotion of Advanced Research)
The main objective of this study would be to characterize
the nature and extent of dysimmunity associated with
schizophrenia and bipolar disorders in two geographically
distinct population groups (French Caucasians and South
Indians)encounteringdistinctenvironmentalfactors.Thiswill
provide insights into the genetic and biological heterogeneity
of these disorders within and across the studied populationgroups, immunogenetic basis of associated auto-immunity,
andenvironmentalinfluencesonhumanHumanEndogenous
Retroviruses-Wfamilyinestablishingthediseaseandrelapsing
episodes.
4.
Analysis of RB1 and p53 gene products in human
brain/nervous system tumors. Investigator: Dr.
R Gope
Thisstudyisaimedtoexploretheeffectofsmallmoleculesonthe
modulationofthelevelandpost-translationalmodification(s)
of RB1 and p53 gene products in human intracranial tumors
invitro.Thehumanintracranialtumorsampleswereexposed
to small molecules and their effects were analysed on tumor
cellsurvival/celldeathinvitro.Thepreliminarydataindicates
that the small molecules modulate the post-translational
modificationssuchasphosphorylationofpRbandp53proteins
onlyinthetreatedsamplesascomparedtotheuntreatedones.
Thesmallmoleculesalsomodulatedtheexpressionsofothercell
survival/celldeathgenesinthetreatedsamplesascomparedto
theuntreatedones.Thepossibleroleofsmallmoleculesinthe
tumorcelldeathinvitroisbeinginvestigated.Theresultscould
Annual Report
leadtodevelopmentofsmallmoleculesaspossibletherapeutics
tomanagethehumanintracranialtumors.
5.
Effect of growth factors and wound healing in
diabetic animal model. Investigator: Dr. R Gope
Thisstudyisaimedtounderstandtheeffectsofgrowthfactors
incutaneouswoundhealingprocessindiabeticmousemodel.
Variousgrowthfactorsandavarietyofsmallmoleculesalone
orincombinationsarebeingtestedfortheirpossiblebeneficial
effects,ifany,onthequalityandrateofwoundhealingprocess.
The preliminary data indicates that these factors accelerated
thewoundhealingprocessinacombinationandconcentration
dependentmannerintheanimalmodel.Thesecombinations/
concentrations also modulated the gene expression patterns
inthetreatedwoundsascomparedtotheuntreatedcontrols.
Thedatashowsthatthesefactorsalsoimprovedthequalityof
thehealedwoundonlyonthetreatedanimalsascomparedto
the untreated ones. Development of these factors as possible
therapeuticstomanagediabeticwoundisbeingevaluated.
6.
Prognostic and predictive significance of p16
and Bmi1 genes in human glioma. Mr. Sibin MK.
Guides: Dr. Chetan GK, Dr. Dhananjaya I Bhat
(Funding by CSIR)
2013-14
the interaction between IL-6 mediated inflammatory and
cholinergic anti-inflammatory pathway will be investigated in
schizophreniapatients.
10.
Evaluation of Immuno-inflammatory pathways
of schizophrenia: Study of potential interactions
between HLA-G, NRG1 and cytokines, Ms.
Ashwini R. Guides: Dr. Monojit Debnath, Dr.
Venkatasubramanian Ganesan (Funding by DST
INSPIRE)
Thisstudyaimstoexplorethenovelrolesofimmuno-modulatory
genes,HLA-GandNRG-1andintergenerationalgeneticeffects
attheHLA-Glociinconferringsusceptibilitytoschizophrenia.
Understanding the potential interactions between HLA-G,
NRG1 and cytokines will help to delineate the pathogenetic
pathwaysofschizophrenia.Inaddition,correlatingtheimpact
of these genetic variations with the dermatoglyphic patterns
(indirectmeasureofneurodevelopmentalabnormalities)would
help in bridging the gap between genetic polymorphisms and
itsimpactonneurodevelopmentinschizophrenia.
Neuroanaesthesia
1.
Comparison between suction above cuff
endotracheal tube (SACETT) and standard
endotracheal tube (SETT) on the incidence of
ventilator associated pneumonia in Neuro ICU.
Investigators: Dr. Sriganesh K, Dr. Sritam,
Dr. Ramesh VJ, Dr. Bhadrinarayan V, Dr.
Veenakumari HB, Dr. Ravikumar R
Evaluation of the effects of 1% propofol on the
cortical and sub-cortical areas of the brain
using functional magnetic resonance imaging
technique. Investigators: Dr. Sriganesh K, Dr.
Saini J, Dr. Bhat DI (Funding by NIMHANS)
7.
Study on the influence of O-6-methylguanine-DNA
methyltransferase (MGMT) gene on downstream
DNA mismatch repair genes in human high grade
malignant glioma. Ms. Jeru Manoj. Guides: Dr.
Chetan GK, Dr. Narasinga Rao (Funding by UGCMaulana Azad National Foundation, UGC, India)
8.
Study on the regulation of human telomerase
in glioblastoma cell lines using knockdown
approaches. Ms. Lavanya CH, Guides: Dr. Chetan
GK, Dr. Srinivas Bharath MM (Funding by UGCRajiv Gandhi National Fellowship, India)
2.
9.
Immunogenetic investigations of Interleukin-6
(IL-6) abnormalities in Schizophrenia. Ms.
Deepthi Venugopal. Guides: Dr. Monojit Debnath,
Dr. Venkatasubramanian Ganesan, Dr. Moinak
Banerjee, RGCB, Trivandrum (Funding by UGC)
This project evaluated the effect of anesthetic drug propofol
ontheBOLDsignalchangesandrestingstatenetworksinthe
brain.TheinvestigatorsobservedreductioninBOLDsignaland
functionalactivityfollowinganesthesiaindifferentareasinthe
brain.ConnectivitybetweenthalamusandPCCincreasedafter
anaesthesiasuggestingdifferentialactionsofpropofol.
This study involves the influence of genetic, gene expression
andepigeneticchangesofIL-6geneontheriskandprogression
of schizophrenia. In addition, the status of anti-alpha7
nicotinic acetylcholine receptor (alpha7nAChR) antibody and
3.
Acute kidney injury in traumatic brain
injury. Investigators: Dr. Sriganesh K, Dr. GS
Umamaheswara Rao
Annual Report
2013-14
patients undergoing surgery ≥2 hours duration
during Suprane Anaesthesia. Investigators: Dr.
Ramesh VJ, Dr. M Radhakrishnan (Funding by
Baxter India Ltd.)
The study evaluated the incidence, risk factors and outcomes
in patients operated for severe TBI at NIMHANS. The
investigatorsobserveda12%incidenceofAKIinthepopulation
anditresultedinprolongedICUandhospitalstayandlonger
durationofventilation.
4.
Blood pressure – Plethysmographic time lag as a
model to quantify systemic vascular resistance:
Design and validation. Investigators: Dr. Ramesh
VJ, Dr. M Radhakrishnan (Funding by Life
Sciences Research Board, DRDO, New Delhi)
The study hypothesis is whether arterial blood pressure –
plethysmographic time lag can be considered to indicate
peripheral vascular resistance. This will enable to noninvasivelyquantifysystemicvascularresistance,andthisalso
hasimplicationinmanagementofpatientswithhemorrhagic
states. The data acquisition has been completed. Majority
of the patients were subarachinoid haemorrhage patients
comingforclippingoftheintracranialaneurysmsandlarge
meningioma patients coming for excision. The time lag
between the waveforms has been calculated. Various other
parameters like pulsatality index, pulse transmit time,
systolic pressure variation, amplitude variation, etc. have
been calculated. Statistical analysis of the parameters is in
progress.
5.
Heart rate variability as a tool to assess autonomic
nervous system in patients with neurosurgical
disorders. Investigators: Dr. M Radhakrishnan,
Dr. Ramesh VJ (Funding by DST)
The study is about assessing the function of autonomic
nervoussystem,intermsofheartratevariability(HRV),in
patients undergoing surgeries for supra and infratentorial
tumors, intracranial aneurysms, cervical compressive
myelopathyandheadinjuries.HRVisassessedbyrecording
theECGfor5minutesandcalculatingtheR-Rintervalsfrom
it.Thisgroupofpatientstendstohavegreaterhemodynamic
fluctuations in the perioperative period. The abnormal
findings of heart rate variability, recorded prior to surgery,
withintraoperativehemodynamicsandconditionofpatients
at discharge from the hospital will be correlated. The data
acquisitionisinprogressanddatahasbeenacquiredinmore
than55patients.
6.
Itisamulti-institutionalstudy.Primaryobjectiveistoobtain
informationonpracticeandusagepatternsofDesfluranewhen
administered in a real-world setting to adult inpatients in
India.Secondary objectives are to evaluate the length of time
forrecoveryfromanesthesiaandthequalityofrecoveryfrom
anesthesia with the usage of desflurane. The data has to be
collectedanduploadedonline.Afterpoolingthedatafromall
the centres, the data will be analysed with respect to various
recoveryparameters.Theparameterswillbecomparedamong
differentagegroups.
7.
Evaluation of the incidence of coagulopathy and
its effect on outcome in patients with traumatic
brain injury (TBI). Investigators: Dr. Sonia
Bansal, Dr. Bhadri V Narayan, Dr. Rohini Surve,
Dr. B Madhusudhana Rao (Funding by ISNACC)
8.
Pre-clinical
and
clinical
imaging
of
microvasculature with quantitative photoacoustic
microscopy.
Investigators:
Dr.
Manojit
Pramanik, EE Department, IISc Bangalore, Dr.
GS Umamaheswara Rao (Funding by NIMHANS)
9.
Confirmation and molecular characterization
of
hospitaland
community-acquired
staphylococcus aureus (HA and CA - MRSA) by
polymerase chain reaction. Investigators: Dr.
HB Veenakumari, Dr. GS Umamaheswara Rao
(Funding by ICMR)
10.
Continuous intraoperative endotracheal tube cuff
pressure monitoring in neurosurgical patients.
Dr. Vinay B. Guide: Prof. Bhadrinarayan.
11.
Validity of surgical Apgar score in predicting
outcome in patients undergoing elective
neurosurgical procedures-A retrospective study.
Dr. Vinay B. Guide: Prof. Bhadrinarayan.
12.
Spectrum of serum sodium disturbances
in
patients
with
non-sellar/
suprasellar
supratentorial tumors. Dr. Sritam Swarup Jena.
Guides: Dr. Ramesh VJ, Dr. Rita Christopher, Dr.
Dhananjaya I. Bhat.
A multicenter, prospective, observational registry
for assessment of clinical outcomes in Indian
adult (≥18-40 years, ≥41-65 and >65 years) in
Annual Report
Sodium disorders are the most common and probably the
most poorly understood electrolyte disorders in neurological
patients. As central nervous system plays an important role
in the regulation of sodium and water homeostasis, patients
sufferingfromCNSinsultfrequentlyexperienceserumsodium
disturbances and it exacerbates their neurologic and general
conditions.Theaimofourstudyistodeterminethefrequency
of sodium disturbance in patients with non-sellar/suprasellar
supratentorialtumorsandelucidateitscorrelationwithclinical
outcome,bothinretrospectiveandprospectivemanner.
13.
Effect of anaesthetics on Glioblastoma cell
line migration, proliferation and matrix
metalloproteinase-2. Dr. Mohit Mittal. Guides:
Dr. Umamaheshwara Rao GS, Dr. Nandakumar
DN
Tumourmetastasisisacomplexprocessthatincludescellular
separationfromtheprimarytumour,invasionofandmigration
through surrounding tissues, invasion of the intravascular
space, cellular transport in the bloodstream, and subsequent
extravasation and proliferation in the target tissue or organ.
Anaestheticsarewidelyusedduringbrainsurgery.Anaesthetics
andanaesthesiatechniqueshavesomeimpactoninvasionand
migration ability of tumor cells that can possibly affect longtermoutcomeofpatientswhohaveundergonecancersurgery.
Thisstudywasplannedtoinvestigatetheeffectofinhalationand
intravenousanaestheticsoncellproliferationandmigrationof
glioblastomacells.
Neurochemistry
1.
Establishment
of
high-throughput
mass
spectrometry-based screening for lysosomal
storage disorders using dried blood spots.
Investigators: Dr. Rita Christopher, Dr. Nagaraja
D (Funding by DBT New Delhi)
Theinvestigatorshaveestablished ahigh-throughput,robust,
and reliable mass spectrometry-based method to screen for
lysosomal storage disorders using dried blood spots collected
on filter paper. The diseases selected in the panel include
Gaucher disease, Pompe disease, Fabry disease, NiemannPickdiseasetypesAandBandKrabbedisease.Thetechnique
hasbeenusedtoscreenbloodsamplesof5100newbornsand
14,000 sick children for these disorders. Two children with
Pompe disease, one with Niemann-Pick disease and two with
Gaucher disease have been identified. At present, effective
enzyme replacement therapy is available for Gaucher, Pompe
2013-14
andFabrydisease.Earlydiagnosisofthesedisordersbeforethe
onsetofirreversiblepathologieswillleadtobetteroutcomesfor
currentandproposedtherapies.
2.
Proteomic analysis of neurological stroke.
Investigators: Dr. Rita Christopher, Dr. Nagaraja
D, Dr. Yasha TC, Dr. Akilesh Pandey (Funding by
DBT, New Delhi)
Thisisamulti-institutionalprojecttoidentifyserumbiomarkers
forstrokeanditssubtypes.Inthefifthyear,usingLTQOrbitrap
VelosFouriertransformmassspectrometry-basedproteomics
approach, quantitative glycoproteomic analysis was done
to identify the serum glycoproteins that are differentially
expressed in acute ischemic stroke (AIS) and intracerebral
hemorrhagicstroke(ICH).InAIS,29proteinswereupregulated
and15,downregulated.Similarly,26proteins(≥2-fold)and11
proteins(≤0.5-fold)werefoundtobedifferentiallyexpressedin
ICH.NovelproteinsupregulatedinAISincludeCD5Lantigen
like protein (CD5L) (2.5-fold), zinc-alpha-2-glycoprotein
(AZGP1)(2.4-fold)andgalectin-3-bindingprotein(LGAL3BP)
(1.7-fold).OtherproteinsupregulatedwereComplementfactor
I (CFI) (2.2-fold), C4b-binding protein (C4BPB) (2-fold),
ComplementC1q(C1QB)(2-fold).Plateletbasicprotein(PPBP)
was downregulated 4-fold. The glycoproteins altered in ICH
includeNeuronalmembraneglycoproteinM6-A(GPM6A)(1.8fold),Angiotensinogenprotein(AGT)(2.4-fold),Synaptophysin
(SYP) (1.5-fold), APOA2 (3-fold), and Calcium/calmodulindependent protein kinase type II alpha (CAMK2A) (2.6-fold).
Of these glycoproteins, candidate proteins were selected for
validation by ELISA. Mean serumlevels of LGAL3BP were
foundtobeelevatedinAIScasescomparedtocontrolsubjects.
SerumC4BPB,AGT,andAPOA2werenotsignificantlyaltered
in stroke cases compared to controls in the ELISA-based
validationstudy.
3.
Vitamin D receptor gene variants and vascular
risk: Study in ischemic stroke. Investigators: Dr.
Rita Christopher, Dr. Nagaraja D (Funding by
ICMR, New Delhi)
Theobjectivesofthisstudyweretoelucidatewhethervariants
of the vitamin D receptor (VDR) gene are associated with
increased risk for ischemic stroke in vitamin D sufficient and
deficientyoungadultsandtoexaminethepossiblemechanisms
bywhichVDRgenevariantsmayaffectvascularrisk.Thestudy
group comprised of 150 control subjects (112 males and 38
females)withmeanageof46.83±13.28and150strokepatients
(115malesand35females)withmeanageof47.53±15.67years.
Body mass index, alcohol, smoking, metabolic syndrome,
Annual Report
2013-14
hypertension,andfamilyhistoryofhypertensionanddiabetes
mellitus were found to be significantlyassociated withriskof
stroke.GenotypingforVDR BsmI,FokIandTaqIwascarried
outbyPCR-RFLP.Allelefrequenciesofthevariousgeneswere
in Hardy-Weinberg equilibrium. VDR gene variants were not
associated with increased risk of stroke in both Vitamin D
sufficient and deficient subjects. There was no association
between serum Vitamin D and the VDR genotypes. Similarly,
therewasnoassociationbetweenVDR genotypesandsystolic
ordiastolicbloodpressure.
4.
Vitamin D status and vascular cognitive impairment
in the elderly. Investigators: Dr. Rita Christopher,
Dr. Chandra SR (Funding by ICMR, New Delhi)
TheobjectivesofthisstudyweretodeterminewhetherVitamin
D insufficiency is associated with increased risk for severe
vascular cognitive impairment in the elderly, to establish
whetherthegenevariantsoftheVitaminDmetabolicpathway
could predict the risk for cognitive decline and to elucidate
thepossiblemechanismbywhichlowVitaminDstatuscould
increase risk for vascular cognitive impairment. A total of
58 healthy controls and 60 subjects with vascular cognitive
impairment have been recruited after informed consent.
GenotypingforvitaminDreceptorgenevariants,namelyTaqI
andBsmI,isbeingcarriedout.
5.
Protective role of Withania somnifera against
scopolamine induced memory impairment in
Alzheimeric rats. Investigators: Dr. Visweswari
G, Dr. Rita Christopher (Funding by DST)
The objectives of this study were to monitor the bioactive
factors from the medicinal plant, Withania somnifera, for
antialzheimeric activity, and to study the pathophysiological
sequelae of neurotransmitter mechanisms in Scopalamineinduced dementia. Adult male Wistar rats, 4 months of age,
with weights between 300-350g, were used for the study.
Increasedacetylcholinesterase(AChE)activityinscopolaminetreatedratswasdecreasedinadose-dependentmannerinall
thefivebrainregionswithmethanolextract(ME)andaqueous
extracts (AE) of the plant. At the same time acetylcholine
(Ach) content was reversed in scopolamine-treated and both
ME and AE treated rats. The changes in AChE activity and
ACh content were maximal with 300mg/Kg b.w. of ME and
AE.Hence,theinvestigatorsconcludethattheseextractswith
this concentration have anti-alzheimeric activity and cause
perceptiblechangesinthecholinergicsystem,atleastaspartof
theiranti-alzheimericeffect.
6.
A study of neuroprotective aspects of Klotho
biology. Investigators: Dr. Vijaya Majumdar, Dr.
Rita Christopher (Funding by DBT)
Variousneuroprotectiveandneurorestorativemechanismsare
deployedbybraincellstomaintaintheirintegrity,tofacilitate
responsestoenvironmentaldemandsandpromotefunctional
recoveryaftercellularinsults.Klotho,anovelanti-agingprotein
has been shown to have a plethora of biological functions
viz., regulation of mineral metabolism, vascular homeostasis,
regulation of metabolic pathways and protection against
oxidativestress.Owingtoitsabundantexpressioninbrainand
itsreportedabilitytomediateapoptosisandcombatoxidative
stress, the investigators propose that Klotho could play a
role of neuroprotectant. The proposed project will attempt to
elucidatetheneuroprotectiveaspectofKlotho’sbiology.Itwill
involvetheanalysisoftheeffectsofoverexpressionofKlothoon
neuronal death caused by exposure to various cellular insults
like oxidative stress, excitotoxicity and trophic deprivation.
ExperimentallythestudywillinvolvegenerationofstablePC12
cells transfected with Klotho encoding plasmid. The control
aswellasKlothooverexpressingcellswouldbetreatedwitha
varietyofcellularinsults,followedbyassessmentofcellsurvival
and apoptotic cell death. This study would also contribute
towardsabetterunderstandingofKlotho’sbiologicalfunction
with respect to the signaling pathways induced by Klotho in
neuronalcells.
7.
Pharmacogenetics
of
oral
anticoagulation
therapy in patients with cardiac valve
replacement. Investigators: Dr. Kalpana SR, Dr.
Rita Christopher, Dr. Manjunath (Funding by
ICMR)
The treatment of rheumatic heart disease with valve
replacementsurgerywithmechanicalprotheticvalvesrequires
lifelong oral anticoagulation, to prevent thromboembolic
complications.However,chronicanticoagulationpost-surgery
ischallengingbecausepatientsexhibitlargevariabilityintheir
dose-anticoagulant effect response thrombotic complication.
The inter-individual variability is known to depend on
environmental factors, but a genetic influence has also been
demonstrated. The two key enzymes in the metabolism of
Acitrom are cytochrome P450 (CYP) 2C9 (CYP2C9 gene)
and the C1 subunit of the Vitamin K 2,3 epoxide reductase
complex(VKORC1gene).Theaimsandobjectivesofthisstudy
are to explore the contribution of CYP2C9 and VKORC1 gene
polymorphisms on optimal therapeutic dose requirements of
oralanticoagulantsinpatientswithcardiacvalvereplacement.
Annual Report
8.
Conformation
dependent
antibodies
as
therapeutic strategies for protein misfolding
disorders. Investigator: Dr. Sarada Subramanian
(Funding by DST, New Delhi)
firstphase,theneutralizingpotentialoftheimmunodominant
epitopeslocatedintheN-terminalregionofTau(residues1850,68-71and111-137)arebeingtestedinratmodels.
10.
Manyneurodegenerativedisordersarefundamentallyassociated
with aging and accumulation of misfolded proteins as amyloid
fibrils. Although such diseases are associated with different
proteins, they share several pathological features. Because
protein misfolding is thought to be central to the pathological
state, it is essential to be able to distinguish such pathological
states from native and non-pathological states. Generation of
conformation specific monoclonal antibodies that bind to the
amyloidfibrilstatewithlittleapparentdependenceonaminoacid
side chain should contribute to the development of diagnostic
and therapeutic agents for protein misfolding diseases. Here,
the efforts were directed to generate conformation-specific
monoclonalantibodiesthatbindtoanddestabilizetheamyloid
fibril state of the misfolded proteins of unrelated protein
sequence, such as amyloid ß (1-42) peptide, islet amyloid
polypeptide,immunoglobulinlightchain,ß2-microglobulin,etc.
Thisnewclassofantibodieswasassociatedwithafundamental
amyloidfoldingmotifandrecognizesacommonconformational
epitope with little apparent dependence on amino acid side
chain information. These antibodies should contribute to the
understandingofamyloidstructure,assembly,andtoxicityand
alsomaybenefitthedevelopmentofdiagnosticandtherapeutic
agentsforconformationaldisorders.
9.
Biochemical and histological analysis of
traumatic brain injury in neurotrauma patients.
Investigators: Dr. Srinivas Bharath MM, Dr.
Nupur
Pruthi, Dr. Shankar SK, Dr. Anita
Mahadevan (Funding by ICMR)
The current project aimed to examine the role of oxidative
damageinthebrainsfromtraumaticbraininjury(TBI)patients.
Theinvestigatorscarriedouthistopathologicalandbiochemical
analysisofthecontusionandpericontusionregionsofthebrain
(frontal cortex) of TBI patients (both surgical samples and
postmortemtissue).Histologicalexaminationofthesesamples
showed elevated astrogliosis (indicated by GFAP expression),
microglialactivation(indicatedbyiba-1expression)andaxonal
damage (indicated by neurofilament phosphorylation). On
the other hand, biochemical analysis showed that contusion
displayed the highest oxidative damage compared to control,
followed by pericontusion. Further, synaptic terminals
showed elevated oxidative damage compared to non-synaptic
mitochondria thereby highlighting the role of oxidative stress
andmitochondrialdamageincontusionandpericontusion.
11.
Tau-focused immunotherapeutic approaches
to Alzheimer’s disease. Investigator: Dr. Sarada
Subramanian (Funding by CSIR, New Delhi)
Alzheimer’s disease (AD) is the leading cause of dementia,
affecting more than 30 million worldwide. The two major
pathological findings in patients with AD are extracellular
plaques formed mainly of amyloid ß (Aß) peptide and
intracellular neurofibrillary tangles (NFT) which contain
hyperphosphorylated tau. The cognitive impairment in
patients with AD is closely associated with loss of synapses
andtheformationofNFTintheneocortexandlimbicsystem.
Potential side effect of current tau-based immunotherapy
targetedprimarilytowardsthecentralprolinerichregionand
thepositivelychargedC-terminalregionisthatitisprohibiting
normal tau from performing its normal cellular functions.
Given that there are multiple phosphorylations on tau, many
ofthemhavebeenreportedtohavepathologicalconsequences;
the identification and selection of the most therapeutically
relevant phospho-epitopes requires further research. In the
2013-14
Nanoassisted C60-pyrimidine derivatives: Their
synthesis, characterization, neuroprotective and
antiviral activities. Investigators: Dr. Srinivas
Bharath MM, Dr. Devashish Sengupta, Assam
University, Dr. Shaheed Jameel, ICGEB, New
Delhi (Funding DBT, New Delhi)
Thecurrentprojectanalysestheneuroprotectiveeffectsofnovel
nanomoleculesinexperimentalmodelsofParkinson’sdisease.
The initial part of the project, involving design, synthesis,
isolation, purification and characterization of the fullerenepyrimidine derivatives, will be conducted and supervised by
thePI(Dr.DevashishSenguptafromAssamUniversity).These
molecules will be tested for potential neuroprotective and
therapeuticpropertiesinvitroinN27dopaminergicneuronal
cell model of Parkinson’s disease. The molecules that show
neuroprotectivepropertyinthecellmodelwouldbetestedin
an MPTP mouse model of Parkinson’s disease. The analysis
in both models includes monitoring of apoptotic markers,
dopaminergicmarkers,redoxandmitochondrialmarkers.
12.
A comparison of biochemical and proteomic
alterations in brain mitochondria of prepubertal
Annual Report
2013-14
and adult mice exposed to 3-nitropropionic acid
(3-NPA). Investigators: Dr. Shinomol George K, Dr.
Srinivas Bharath MM (Funding by DST, New Delhi)
The project aimed to determine the biochemical changes
mediated by 3-Nitropropionic acid (3-NPA) in vitro and in
vivo. The 3-NPA caused dose dependent neurotoxicity in
dopaminergic cells in vitro, along with increased oxidative
stress, lowered antioxidant function (depletion of glutathione
etc.) and mitochondrial damage. Injection of 3-NPA in mice
(youngandadult)causedsignificantmotordeficitsasindicated
bybehavioralassays(poletest,stridelengthandrotarodassay).
The mice also displayed mitochondrial damage (indicated by
lowered activities of mitochondrial respiratory complexes
andATP/ADPratio)andelevatedoxidantmarkers(indicated
by elevated protein oxidation and lipid peroxidation) in the
striataltissue.Alltheseeffectswerecomparablebetweenyoung
andadultanimals.
13.
Analysis of the epigenetic regulation of red/ox
mechanisms in neurotoxic models of Parkinson’s
disease: Role of chromatin modifications.
Investigators: Dr. Mythri R, Dr. Srinivas Bharath
MM (Funding by DST, New Delhi)
Studies in Parkinson’s disease demonstrate that red/
ox mechanisms and mitochondrial damage contribute to
neurodegeneration in PD. Oxidative stress and lowered
antioxidant function are closely linked with the expression of
genes such as NRF-2 pathway genes (Phase II pathway). The
expression of these genes could be modulated by epigenetic
mechanisms including histone acetylation mediated by
histone acetyltransferases (HATs)], resulting in increased
transcription. In contrast, histone deacetylation [by histone
deacetylases(HDACs)]repressesgenetranscription.Oxidative
stress activates the expression of stress response kinases and
redox-sensitivetranscriptionfactorsprobablyviatheactivation
of intrinsic HAT activity and inhibition of HDAC activity.
Interestingly, acetylation on specific lysine on core histones
hasbeenimplicatedinpathologicalconditionssuchascancer,
ischemia and neurodegeneration. Although oxidative insult
induces epigenetic changes, the status of histone acetylation/
deacetylation at specific lysines and altered HAT/HDAC
dynamics, with relevance to oxidative stress and red/ox
genes in PD has not been completely delineated. The current
proposalaimsto(i)investigatethedynamicsofspecifichistone
acetylation/deacetylation events and HAT/HDAC activities
and(ii)correlatehistoneacetylationeventswiththeexpression
ofred/oxgenesintheMPTP/MPP+modelofPD.
14.
Role of Glutamate excitotoxicity and cytokines
in invasion of glioblastoma. Investigators: Dr.
Nandakumar DN, Dr. Sampath S, Dr. Vani
Santosh (Funding by DBT, New Delhi)
Glioblastoma (GBM) is one of the most common malignant
tumoursofthecentralnervoussystem.Despitenewdiagnostic
techniques and combined modality therapy prognosis
remains dismal. Decades of surgical therapy, radiotherapy
and chemotherapy have failed to drastically change survival.
Theadditionoftemozolomidetoradiotherapymedianoverall
survivalhasimprovedfrom12.1monthsto14.6months.They
haveexceptionalabilitytoinfiltratenormalbrain,oftenalong
blood vessels or nerve fibres. This feature makes complete
radical surgical resection virtually impossible and leading
in almost all cases to tumor recurrence. Their genetic and
metaboliccharacteristicsaffectinginvasiveability,alterationof
immuneresponseandthedevelopmentoftreatmentresistance
mustbeunderstoodindetailtoaddresstheminameaningful
fashion.Oneofthedistinguishingfeaturesofthegliomatumors
is their diffuse infiltrative nature. Several factors are thought
tocontributetotheinvasiveandmigratorypropertiesofGBM
cells, interacting with the microenvironment and enhancing
motilityandinvasion.
Theinvestigatorsaimatunderstandingglutamateexcitotoxicity
in GBM and the role of cytokines on invasiveness of tumour
and by doing so, perhaps, contribute to the understanding of
thecomplexbiologicalinteractionsthatregulateglioblastoma
migration,invasionandrecurrence.
15.
Genetic and biochemical profiling of patients
with glutaric aciduria type I. Investigator: Dr.
Kruthika Vinod TP (Funding by DST, New Delhi)
Glutaric acidemia type I, is an autosomal recessive disorder
ofaminoacidmetabolismandcausedduetodeficiencyofthe
enzymeglutaryl-CoAdehydrogenase,amitochondrialenzyme
located in the degradative pathway of the amino acids lysine,
hydroxylysine and tryptophan. The aim of this project is to
correlate biochemical phenotype with its respective genotype
andtoknowtheprevalenceoflowexcretesanditsgenotypein
Indianpopulation.Thefindingfromthisstudy,willimprovise
thediagnosticsensitivityandspecificityofneonatalscreening
for GA-I and in addition it also helps in acquiring accurate
figuresonitsprevalenceinthepopulation.
16.
Generation of experimental models of muscular
dystrophy: Analysis of molecular mechanism and
Annual Report
myoprotection. Investigators: Dr. MM Srinivas
Bharath, Dr. Gayathri N (Funding by ICMR)
Diagnosisandtreatmentofmusculardystrophies(MDs)such
as Duchenne muscular dystrophy (DMD) and limb girdle
muscular dystrophy (LGMD) is a major healthcare challenge
in India. Although several factors downstream of genetic
mutations, such as oxidative stress, mitochondrial damage,
calciumdynamics,signaltransductionpathwaysetc.havebeen
implicatedinmusclepathology,theinterplayandthechronology
of these mechanisms have not been completely understood.
Cardiotoxin-mediated simulation of a muscular dystrophic
pathologyin vitroandin vivooffersanexperimentalmodelto
studythepathwaysinvolvedindegenerationandregeneration
of muscle and to evolve novel therapy for a multitude of
musculardystrophyandextrapolatedtothehumancondition
tounderstandtheroleofdifferentpathwaysinMDsandhow
theycanbemodulatedfortherapy.Thestudyisunderway.
17.
Pharmacogenetics of oral anticoagulation in
patients with cerebral venous thrombosis. Ms.
Tanima De. Guides: Dr. Rita Christopher, Dr.
Nagaraja D (Funding by CSIR)
The impact of CYP2C9 and VKORC1 -1173C>T and 1639G>A
polymorphisms on acenocoumarol, a commonly prescribed
oralanticoagulantdrug,wasinvestigated.476acenocoumaroltreated CVT patients were genotyped for CYP2C9 and
VKORC1 -1173C>T and 1639G>A polymorphisms. Mean
acenocoumarol dose required for achieving and maintaining
a stable international normalized ratio (INR) was calculated
for different genotypes. The effect of co-administration of
the anticonvulsant drug, phenytoin, was also determined. A
significant association was observed between the mean dose,
clinicalcovariates,andtheVKORC1-1639andCYP2C9variant
genotypes. An algorithm for acenocoumarol dose calculation
wasdevelopedforpatientswithCVT.
18.
Mass spectrometry based protein profiling to
identify candidate biomarkers in biological fluids:
Study in stroke. Mr. Rakesh Sharma. Guides: Dr.
Rita Christopher, Dr. Nagaraja D (Funding by
DBT)
Proteins present in serum of ischemic and hemorrhagic
stroke patients were profiled using iTRAQ based LC-MS/
MS approach. In ischemic stroke 65 proteins exhibited a foldchange >1.5 whereas in hemorrhagic stroke 69 proteins were
upregulatedand48downregulatedAlteredlevelsofpotential
2013-14
candidateproteinssuchasVonWillebrandfactor,ADAMTS13,
S100 A7, Apolipoprotein CII, Apolipoprotein C III PSD-95,
Peroxiredoxin-2, Ficolin 2, Dermicidin, Fibrinogen-gamma,
ApolipoproteinCIIIAntileukoproteinase,Vasodilator-stimulated
phosphoprotein,Galactin-3-bindingprotein–werevalidatedby
ELISA.Thepanelofcandidatemarkersidentifiedfromthestudy
mayassistexistingmodalitiesinthediagnosisofstroke.
19.
Circulating microRNAs: Role as molecular
biomarkers in cerebral small vessel disease. Mr.
Prabhakar P. Guides: Dr. Rita Christopher, Dr.
Chandra SR (Funding by ICMR)
MicroRNAs(miRNA)areinvolvedintheregulationofdiverse
cellular processes, and may serve as points of cross-talk
between signaling pathways. MicroRNA deregulation often
resultsinimpairedcellularfunctionanddiseasedevelopment.
Cerebral small vessel disease (SVD) is a common cause of
vascular dementia and age-related cognitive decline. The aim
of this study is to identify differentially expressed miRNAs
in SVD and validate the differentially expressed miRNAs as
molecularbiomarkerstodiagnoseSVD.Thestudyalsoaimsto
identify target genes for the differentially expressed miRNAs
and predict the role of differentially expressed miRNA in the
etio-pathogenesisofSVD.
20. Parental consanguinity and its association with
metabolic abnormality in schizophrenia patients
living in a rural community of South India: A
clinical and genetic investigation. Mr. Vikas
Agarwal. Guides: Dr. Jagadisha Thirthalli, Dr.
Rita Christopher, Dr. Naveen Kumar C
Theassociationofconsanguinityandmetaboliccomplications
in patients with schizophrenia remains unexplored. The
objective of this study is to compare the degree of parental
consanguinitybetweenschizophreniapatientslivinginarural
community in South India and healthy controls in the same
community and to examine the association between parental
consanguinity and metabolic abnormalities in patients with
schizophrenia. This study is expected to provide insights into
thecomplexmechanismofmetabolicabnormalitiesassociated
withschizophrenia,theroleofparentalconsanguinityandthe
roleofrecessivetransmissionofriskfactorsforthedevelopment
ofmetabolicabnormalitiesinschizophrenia.
21.
Determinants of cognitive dysfunction in patients
with neurocysticercosis correlation with CSF
acetyl cholinesterase, serum TNF alpha and
Annual Report
2013-14
IL-10 activity. Dr. Vinod Varghese. Guides: Dr.
Chandra SR, Dr. Rita Christopher, Dr. Jamuna
Rajeswaran, Dr. Chandrajit Prasad, Dr. Subasree
This prospective, hospital-based study was aimed at
determining the factors which could be related to cognitive
decline in neurocysticercosis. Acetylcholinesterase present in
the cyst capsule was expected to deplete acetylcholine in the
brainandcausecognitiveimpairment.Theresultsshowedthat
even though there was an increase in acetylcholinesterase in
CSFofpatientswithneurocysticercosis,itwasnotstatistically
significant. There was a significant correlation of cognitive
impairmentwiththenumberofMRIlesions.SerumTNF-alpha
and IL-10 were significantly increased and correlated with
vesicularstages.Itislikelythatcognitiveimpairmentisdueto
inflammation-triggeredneurodegeneration.
22. Genetic determinants of cognitive dysfunction in
patients with cerebral small vessel disease. Dr.
Vinod Varghese. Guides: Dr. Chandra SR, Dr.
Rita Christopher, Dr. Jamuna Rajeswaran, Dr.
Chandrajit Prasad, Dr. Subasree
Genetic predisposition has been suggested to be critical for
development of cerebral small vessel disease (SVD). The role
of aldosterone synthase CYP11B2 T-344C polymorphism
in vascular cognitive dysfunction associated with SVD was
investigated.The study showed no statistically significant
associationbetweengenotypesandcognitivescoringalthough
CYP11B2 TC genotype was associated with hypertension in
men. However, significant association between hypertension
and homocysteinemia with the severity of brain MRI white
matterchangeswasfound.
23. Role of ubiquitin c terminal hydrolase and s-100β
in predicting deficits in cognitive control in
young adults with mild traumatic brain injury A prospective study. Dr. Subir Dey. Guides: Dr.
Jagath Lal, Dr. Rita Christopher
The aim of this study is to determine whether the proteins,
ubiquitin c terminal hydrolase and s-100β could be used as
biomarkers to predict deficits in cognitive control in young
adultswithmildtraumaticbraininjury.
24. Small molecule inhibitors of amyloid ß
aggregation and toxicity – An in vitro study. Ms.
Maya Mathew. Guides: Dr. Sarada Subramanian
In search of small molecules as an effective strategy for AD,
plants being used in Ayurveda for treating dementia and
cognitivedysfunctionwereconsidered.TheseincludedNelumbo
nucifera, Valeriana wallichii, Celastrus paniculatus, and
Raulfia serpentina. The effect these extracts and their active
phytocompoundsweretestedforinhibitionofAβoligomerization
and protection against Aβ mediated toxicity in rat primary
hippocampal cultures. The results showed that, β-sitosterol,
valerenicacid,α-asaroneandglycyrrhizinwereeffective.These
substancesmayholdtherapeuticpotentialforADtreatment.
25. Role of ghrelin-leptin (im) balance on Alzheimer’s
disease. Ms. Sowmya Madhavadas. Guides:
Dr. Sarada Subramanian, Dr. Bindu M Kutty
To investigate the role of obesity on cognitive functions,
monosodium glutamate (MSG) was first administered to rat
pupsatneonatalstages.Bysixmonths,hypercholesterolemia,
hyperglycemia and leptin resistance were established. Serum
leptin levels showed inverse significant correlations with
hippocampal weights (r = -0.77, p< 0.05). Administration of
ghrelin receptor analog [D-Lys (3)] GHRP-6 to 18-month-old
obese rats resulted in significant reversal of leptin resistance
leptin with concomitant reduction in hippocampal amyloid
β, cholinesterase levels with marked improvement in Barne’s
mazetask.Thesefindingssuggestthepotentialof[D-Lys(3)]
GHRP-6asapromisinganti-Alzheimercandidate.
26. Recombinant expression and characterization of
core sequence of the various isotypes of human
14-3-3 protein and development of isoform
specific immunoassays. Ms. Udaya Kumari HB,
Guide: Dr. Sarada Subramanian
The 14-3-3 protein belongs to a family of conserved, dimeric
proteinswithamonomericmolecularmassofabout30kDa,and
isubiquitouslyexpressedinvariousmammaliantissues.Seven
isoformsoftheseproteinscanbedetectedinthecerebrospinal
fluid of patients with different neurological disorders. The
objective of the proposed study is to develop isotype specific
immunoassay for each isoform of the 14-3-3 protein. Towards
this,theindividuallinearantigenicdeterminantsspecifictoeach
isoformofthe14-3-3proteinwereselectedbyusingpredictive
algorithms. Custom synthesis and production of polyclonal
antibodiestotheseindividualsequencesisunderway.
27.
Molecular event related to
Nitrosative
stress
during
oxidative and
brain
aging,
Annual Report
neurodegeneration and neurotrauma. Mr. Harish
G, Guide: Dr. Srinivas Bharath MM (Funding by
ICMR)
The study demonstrated that the redox status, mitochondrial
physiology and proteomics in the human brain are highly
dynamic and inter-related. These processes are regulated
by pre/postmortem factors, aging, degeneration and injury.
Nevertheless,oxidativeandmitochondrialchangesarecommon
eventsthatlinkaging,degenerationandinjurymechanismsin
the human brain. The data also indicated the persistence of
signaturepatternofredoxmarkersinnon-traumatizedregions
of young and old brains. In the injured regions of the brain,
distinct biochemical, pathological and proteomic changes
differentiatecontusionfromthepericontusionregions.
28. Evaluation of the mechanisms associated
with neurotoxicity in cell and animal models
and neuroprotection by natural products:
Implications for Parkinson’s disease. Mr.
Raghunath N, Guide: Dr. Srinivas Bharath MM
(Funding by CSIR-SRF)
Parkinson’s disease (PD) is a neurodegenerative disease
that occurs due to the gradual degeneration of dopaminergic
neurons leading to the loss of striatal dopamine. Research
evidences have revealed the contribution of various genetic
and environmental factors in PD pathology. Environmental
factors include exposure to pesticides and toxic metals such
as manganese. Acute exposure to Mn has been demonstrated
toinduceneurotoxicitybothin vitroandin vivo.Thecurrent
study aims to understand the role of oxidative stress and
mitochondrial damage in Mn-dependent neurotoxicity in
dopaminergicneuronalcellsandinmiceusingtranscriptomic
andepigeneticapproaches.
29. Comparative analysis of cellular changes
in Duchenne Muscular Dystrophy (DMD),
sarcoglycanopathies and other muscle diseases:
Focus on mitochondrial function. Ms. Debashree
Bandopadhyay. Guides: Dr. Srinivas Bharath
MM, Dr. Gayathri N, Dr. Nalini A
Muscular dystrophies (MDs) arise due to muscle protein
defects. Molecular mechanisms underlying MDs include
necrosis/apoptosis, inflammation, calcium dysregulation etc.
The role of mitochondrial dysfunction and oxidative stress in
muscledamageanddegenerationisbeingrecognized.Analysis
ofamousemodelofmuscledegenerationfromthelabclearly
2013-14
demonstrated the role of oxidative stress and mitochondrial
damage in muscle pathology. However, the status of these
processesisnotthoroughlyinvestigatedinhumanmuscle.The
current project aims to characterize human MDs and related
muscle pathologies with a focus on mitochondrial function
usingbiochemical,histologicalandproteomicmethods.
30. Epigenetic analysis in the 3-nitropropionic acid
(3-NPA) model of neurotoxicity: Implications for
neurodegenerative diseases (Tentative title). Ms.
Ranganayaki S, Guide: Dr. Srinivas Bharath MM
3-Nitropropionic acid (3-NPA) is a fungal toxin and a food
toxin that causes neurotoxicity in the striatum via inhibition
ofmitochondrialcomplexIIleadingtomitochondrialdamage.
3-NPA is known to cause dose-dependent neurotoxicity in
dopaminergic cells in vitro, along with increased oxidative
stress,loweredantioxidantfunction(depletionofglutathione,
etc.) and mitochondrial damage. The current project aims to
characterize the epigenetic mechanisms induced by 3-NPA in
cellmodelbyanalyzingthe(i)statusofthepost-translational
modifications of histones such as acetylation (ii) activities of
histone acetyl transferases and histone deacetylases both in
vitroandinvivo.
31.
Role of IL1beta, IL6 and glutamate receptors in
invasion of glioblastoma. Ms. Hurmath Fathima
K. Guides: Dr. Nandakumar DN, Dr. Sampath S
Glioblastoma multiforme (GBM) is one of the most common
primarybraintumorswithpoorprognosisandhighlyinvasive
behavior.Glutamatehasbeenimplicatedasanimportantplayer
inthegrowthandinvasionofgliomas.IL-1βhasbeenimplicated
in glioblastoma invasiveness. Evidence has emerged on the
interplaybetweenIL-1βandexcitotoxicityincaseofischemic
brain damage. In gliomas, the level of IL-6 gene expression
increaseswiththegradeofmalignancy.Theinvestigatorsaim
tolookattheeffectoftheinterleukinsIL-1βandIL-6onglioma
cells, as well as their interplay with glutamate receptors to
mediatetheiraction.
32. Role of glutamate excitotoxicity, TNF-alpha and
IL-13 in the invasion of high grade glioma. Mr.
Palaniswamy R. Guides: Dr. Nandakumar DN,
Dr. Dwarakanath
Highgradegliomasarelethalasitinfiltratesthesurrounding
brain tissue. Glutamate uptake is reduced and excitotoxic
concentrations of glutamate are released, leading to glioma
Annual Report
2013-14
growth.Eighty percent ofthe high-grade gliomasarepositive
forTNF-αandthedecoyreceptorforIL-13,IL-13Rα2protein
isexpressedathighlevelsonlyinhigh-gradegliomacells.No
studyisavailableontheroleofinvasionmediatedbyglutamate
excitotoxicity,TNF-αandIL-13.Theinvestigatorsaimtostudy
thedirectroleoftheseoninvasionandcrosstalkbetweenthese
moleculesanditssignalingpathway.
33. Biochemical and histopathological study of
duchenne muscular dystrophy (DMD) and
related neuromuscular disorders. Ms. Renjini R.
Guides: Dr. MM Srinivas Bharath, Dr. Gayathri
N, Dr. Nalini A (Funding by CSIR)
ACTX-mediated transient acute mouse model of muscle
degeneration that displayed inflammation and degeneration
at days 1 to 7 and subsequent regeneration at day 11 and
beyondwasgenerated.Itwasfoundthatlimbstrengthdeficits
resembled human MDs and inflammatory myopathies. The
histopathologicalfindingsofacuteinflammation,degeneration
and the ultra-structural evidence of sarcolemmal disruption
were characteristic of human MDs and inflammatory
myopathies. Expression of cytokines, cytokine receptors
and apoptotic mediators were found to be increased in the
degenerativephase.Themodelalsodisplayedcalciumdeposits
duringdegeneration.Theprocessofcalciummediateddamage
wasbycalciuminfluxintomitochondriacausingdepolarization
and increased ROS. Proteomic analyses confirmed oxidative
damage of six proteins from DMD samples compared to
controlsamongwhichtwoweremitochondrial.
The investigators found that the phytochemical curcumin
hastened the functional recovery of the CTX treated muscle
and cell model. The tissue repair, regeneration and recovery
of sarcolemmal stability in the curcumin treated muscle were
relatively faster compared to the controls. Further, GSH
production was significantly improved with concomitant
reductioninlipidperoxidationfollowingcurcumintreatment.
Curcumin and similar molecules might have therapeutic
benefitswithimplicationsforhumanmusclediseases.
NIIR
1.
fMRI correlates of auditory discrimination
in auditory Dys-synchrony: A Voxel-based
Morphometry Study. Investigators: Dr. Rose
Dawn Bharath, Dr. AK Gupta, Dr. Jayaram V, Mr.
Naveen (Funding by NIMHANS)
Results of the group analysis rendered over a glass brain representing areas
which were seen significantly larger in patients with auditory dysynchrony
compared with controls.
Auditory dys-synchrony describes a condition in which a
patient’s otoacoustic emissions (OAE) are (or were at one
time) present and auditory brainstem responses (ABR) are
abnormal or absent. In some instances, it is identified on the
basis of present cochlear microphonics (CM) and abnormal
or absent ABRs with or without abnormalities of OAEs. All
subjectswerestudiedusingahighresolutionanatomicalscan
of the whole brain acquired in 3.0 Tesla Siemens Skyra MR
Scanner with 20-channel head coil using a three dimensional
T1 weighted sagittal magnetisation prepared rapid gradient
echo (MP-RAGE) sequence in 192 slices with TR: 1900 ms;
TE:2.44ms;TI:900ms;FOV:250x250;Resolution:256x256;
Slicethickness:1mm.Voxelbasedmorphometryanalysiswas
done using VBM8 toolbox of SPM8 comparing the group of
auditory dys-synchrony patients with the group of healthy
controls.Results demonstrated structural brain differences
in auditory dys-synchrony patients in areas including right
superior temporal gyrus, bilateral anterior cingulate, left
Annual Report
cingulategyrus,leftuncus,bilateralinferiorfrontalgyrus,right
precentralgyrus,leftmiddlefrontalgyrus,leftsuperiorparietal
lobule, post central gyrus and left sub-lobar putamen when
compared with healthy controls. Voxel based morphometry
group analysis of patients compared with controls revealed
significantvolumetricchangespredominantlyinvolvingsensory
andmotorcortices.Thisfindingcouldimplycorticalplasticity
inpatientstoaccommodatefortheauditoryneuropathy.
2.
3.
rCBV as compared to both non-responders and surgically
excisedlesions.Theinvestigatorsconcludethatpresenceofvery
low rCBV values on initial scan in a tuberculoma may be the
reasonfornonresponsetoantituberculoustherapy,andmaybe
anindicatorofanearlyexcisionespeciallyinlargelesionsand
lesionsinposteriorfossa.
4.
Brain organization in normative multilingualism.
Investigator: Dr. Rose Dawn Bharath (Funding
by DST)
Languageisasystemofbraincircuits.FunctionalMRIisbeing
increasinglyusedtounderstandthedynamicsofbraincircuits
especially language. The study was undertaken to assess the
neuralsystemsoflanguageinbilingualsbymeansofantonym
generationinTamiltoTamil(TT),EnglishtoEnglishLanguage
(EE)andcodeswitchingbetweenTamiltoEnglish(TE)using
functional Magnetic Resonance Imaging (fMRI). Proficient
16TamilnativespeakersfromruralTamilNadu,SouthIndia
participated in the study. Tamil (L1) was first language and
English (L2) second language. The Blood Oxygenation Level
Dependent (BOLD) signal showed TT uniquely activated
prosody and EE activated semantic processing and visual
attentionseparately.Thecommonareasforboththelanguages
involvedhigherordercognitiveprocessinglikecentralexecutive
of working memory, error monitoring, cognitive control,
subvocal speech, auditory rehearsal, semantic fluency and
visual processing. The code switching task TE was mediated
by executive processes, cognitive control, visual attention,
semanticprocessing,memoryretrieval,emotionalprocessing,
visualprocessing,motor-programmingandarousal.Hence,the
language processing in the brainrequires executive processes
andcognitivecontrols.
The role of T2* perfusion in therapeutic response
assessment of CNS tuberculomas. Investigators:
Dr. Anatharam, Dr. Rose Dawn Bharath
Theinvestigatorsconductedserialfunctionalimaginganalysis
using T2* perfusion in 19 patients with tuberculoma with an
aimofevaluatingtheroleofperfusionparametersinpredicting
response to standard treatment with ATT. Analysis results
found that, of the 19 cases of brain tuberculomas evaluated
using T2* perfusion, 13 cases with high rCBV on initial scan
showedclinicalandimagingimprovement.Sixcaseswithlow
rCBVoninitialscandidnotrespondtotreatment.Treatment
responders showed statistically significant higher values of
2013-14
Comparison of different sequences of images for
effective brain tumor detection, segmentation
and volume measurement. Investigators: Dr.
Chandrajit Prasad, Dr. AK Gupta (Funding by
NIMHANS)
Inthisproject,theinvestigatorshavepresentedaKnowledgeBased Brain Tumor segmentation system. It was designed,
tested and evaluated for efficient brain tumor segmentation.
Two radiologists hand-labeled the tumor slices of interest.
Performance parameters were drawn by comparing the
manuallylabeledsliceswiththeonesgeneratedbyKBBTS.The
images displayed in the results showed that the system was
successfulinsegmentingthetumorfromhealthybrainpixels.
Themeanvaluesforsensitivity,specificity,accuracy,PPVand
NPVwerefoundtobe94.79%,99.6%,and99.39%,91.64%and
99.76%respectively
5.
The role of Electroencephalogram functional
Magnetic Resonance Imaging (EEG-fMRI) in
assessing the neuro-hemodynamic changes
induced by Repetitive Trans Cranial Magnetic
Stimulation (rTMS) in patients with Writer’s
Cramp. Dr. Bhaskar MV. Guides: Dr. Arun Kumar
Gupta, Dr. Rose Dawn Bharath, Dr. Pramod Pal
The investigators conducted fMRI EEG study on 18 patients
withwriter’scrampimmediatelybeforeandafter(1Hz)rTMS
session. It was found that rTMS induced hemodynamic and
electricalcorrelatesweresignificantlyhigherevenaftersingle
session of rTMS. The changes induced by rTMS was not just
localized to the subjacent motor cortex but was widespread
to even involve the cerebellum. The changes varied between
dominantrighthandmotortaskandnon-dominantleftmotor
task. Visual correlation analysis of rTMS induced changes in
beta spectral power had a similar pattern of distribution on
simultaneouslyacquiredEEG.However,changesincerebellum
and deeper structures could not be visualized on EEG. The
investigators conclude that fMRI is a reliable modality in
assessing changes induced by rTMS in patients with writer’s
cramp and hence can be a potential tool for development of
biomarkerswhileassessingrTMSinducedbrainplasticity.
Annual Report
6.
2013-14
Clinical
and
angiographic
outcome
of
endovascular management of the ruptured and
unruptured posterior circulation aneurysms. Dr.
Bhaskar MV. Guides: Dr. Arun Kumar Gupta, Dr.
Arvinda HR, Dr. BIndira Devi
A retrospective study of 82 patients treated by endovascular
technique of all the posterior circulating aneurysms, from
November 1998 to December 2013 was done to evaluate the
immediate and long term efficacy, angiographic and clinical
outcome of endovascular treatment of posterior circulation
aneurysms.Themeanageofpatientswas44.6years.Majority
of the patients were females (n=46, 56%), the ruptured
aneurysms were 78%, the most common symptom was
headache(84%),SAH=Fischergrade3(n=30,46%),followed
byFischergrade4(n=22).Unrupturedaneurysmswere18in
number. The decreasing order location were in basilar artery
(trunk and its bifurcatuion, 35.3%), followed by vertebral
artery(n=19,23%)andposteriorcerebralartery(n=16,19.5%).
Narrow neck noted in majority of patients (54.8%) and
multiple aneurysms in 7 cases (8.5%). The coiling alone was
donein34%,stentassistedcoilingin22.6%andparentartery
occlusionsin21.3%ofcases.Majorityhadnormalangiography
(84%) on follow up, 6 cases showed residual aneurysms, one
casewithregrowthofaneurysm.Mortalitywasseenin6cases
(7.3%) and significant morbidity in 3 cases (3.6%). The trend
of endovascular technique increased in recent 5 years (58%),
and42%inlast10years.Thestudysuggeststhatendovascular
treatment provides a reasonably safe and effective method
of treatment for treatment of both ruptured and unruptured
posteriorcirculationaneurysms.
7.
Magnetic
resonance
imaging
and
neuropsychological abnormalities in survivors
of herpes simplex encephalitis. Dr. Gorky Medhi.
Guides: Dr. AK Gupta, Dr. Jitender Saini, Dr.
Netravathi M, Dr. Keshav Kumar
1.
International retrospective comparison of nontraumatic spinal cord injury rehabilitation
outcomes. Investigator: Dr. Anupam Gupta
First retrospective phase of this international project is
completed and the prospective phase will commence from
April2014.Thisinternationalprojectwasinitiatedintheyear
2009with8spinalinjurycentresparticipating.Latertwomore
centers joined and now the project has participation of 10
centersacrossfivecontinentsoftheworld.Theobjectiveofthis
projectwasseeingtheinfra-structureavailableacrosstheworld
for spinal cord injury (SCI) patients both in developed and
developing worlds. The infrastructure includes availability of
rehabilitationphysiciansinthesecentersaswellasparamedical
staffsuchasnursing,physiotherapists,occupationaltherapists,
psychologists,socialworkers,orthotists,counselors,etc.among
others.
Other than the staff, the facilities available for rehabilitation
ofthispatientpopulationlikeurodynamiclabs,balance&gait
training labs, ADL skills training labs etc were also observed,
noteddownandcomparedamongthecentres.
The etiopathological causes of SCI, epidemiology of SCI in
hospitals,barrierstoadmissionanddischargeforthesepatients
were also noted down, compared and analysed. Patients’
neurological and functional recovery status with inpatient
rehabilitationwasalsocompared.
The prospective phase of this project would consist of
longitudinalstudyinthepopulationgroupandwouldfocusnot
only on the abovementioned issues but also other associated
complications and co-morbidities observed in these patients
usingISCoSdataset.
2.
Comparison
of
antipsychotics
for
nonneurological adverse effects- Pilot study.
Investigators: Dr. Anupam Gupta, Dr. Preeti
Sinha (Funding by NIMHANS)
Thisresearchproposalaimstoexaminepatientswithpsychotic
disorderwhoarestartedonmonotherapywithChlorpromazine,
Clozapine, Olanzapine or Risperidone in either in-patient or
out-patient setting in prospective manner for a period of 14
weekstoassessthepatternandtime-courseofantipsychotics
emergentadverseeffectsincludingsexualeffects,enuresisand
postural hypotension and explore urodynamic parameters of
antipsychoticsemergentenuresis.
3.
Prevalence of depression, fatigue and sleep
disturbances in myelopathies and their relation
to functional and neurological recovery. Dr. Nitin
Menon. Guides: Dr. Anupam Gupta, Dr. Meeka
Khanna.
Thepurposeofthestudyistoidentifyprevalenceofdepression,
fatigue and sleep disturbances in myelopathy patients and to
Annual Report
comparetheseindicatorswithstandardoutcomemeasuresin
spinal injuries to determine their correlation with functional
outcome and neurological recovery. Outcome measures/
instruments included in the study are: Fatigue Severity Scale
(FSS);HospitalAnxietyDepressionScale(HADS);Pittsburgh
Sleep Quality Index (PSQI); Barthel Index; Spinal Cord
IndependenceMeasures(SCIM)
cortical inhibition as evidenced by reduced silent period with
escape discharges suggesting asymptomatic changes in the
gabanergic system in these patients opening the role of the
therapeutic role of GABA agonists in addition to serving as a
biomarker in early diagnosis. In patients with AD,CMCT was
normalbutcorticalinhibitionwasreduced.
4.
4.
Study of effectiveness of robotic hand therapy in
patients with stroke: A pilot study. Dr. Nidhi Rawat.
Guides: Dr. Meeka Khanna, Dr. Anupam Gupta
The purpose of the study is to assess the efficacy of Amadeo
robotic hand therapy in stroke patients. It is a prospective
observational study in which data of patients diagnosed with
strokewithresidualhemiparesisofeitherside,bothin-patient
andout-patient atDepartment ofNeurological Rehabilitation
(DNR),NIMHANS,Bengaluru,betweenstudyperiodOctober
2013 to May 2014, fulfilling inclusion criteria, would be
collected.Allpatientswouldreceive15sessionsoftrainingby
theroboticsystem.
Outcome measures/ instruments included in the study are:
(i) The Fugl-Meyer Assessment (FMA) of upper-extremity
function(Upperextremitymotorscore;Upperextremityrange
of motion score; Upper extremity pain score) (ii) Medical
ResearchCouncil(MRC)score(iii)ForceandROMassessment
onAmadeohandrobot
Neurology
1.
Lafora body disease – Role of malin and ubiquitin
protisome pathway in the pathogenesis.
Investigators: Dr. Nihar Renjen Jena, Dr.P
Satishchandra, Dr. Sudeendra Rao, NBRC, New
Delhi (Funding by DST)
2.
Kerala-Einstein Study: Healthy lifestyle, vascular
disease, and cognitive decline. Investigators: Dr.
PS Mathuranath, Dr. Joe Verghese (Funding by
National Institute of Health)
3.
TMS as a biomarker to differentiate cortical
dementias. Investigator: Dr. SR Chandra
Transcranial magnetic stimulation showed central Motor
conductiontimeprolongedinfrontotemporaldementias.There
was evidence for increased cortical excitability and decreased
2013-14
Factors determining cognitive impairment in
neurocysticercosis. Investigator: Dr. SR Chandra
CognitivedysfunctioninNCCisnotrelatedtothesiteofNCC
but it increased with the increasing number, vesicular stage,
pro inflammatorycytokine levels as well as there was a trend
withcholinesteraselevels.
5.
Role of the aldosterone synthase CYP11B2 T-344C
polymorphism in vascular cognitive dysfunction
associated with SVD. Investigator: Dr. SR
Chandra
Cognitive dysfunction: The CYP11B2 T-344C gene polymorphism
showed an increasing association with hypertension and
hyperhomocystenemia but its role in determining cognitive
impairmentincerebralSmallVesseldiseasecouldnotbeestablished.
6.
Genetic determinants of cognitive impairment in
cerebral small vessel disease. Investigators: Dr.
Chandra SR, Dr. Rita Christopher (Funding by
ICMR, New Delhi)
Theaimsandobjectivesofthisproposedresearcharetostudy
the contribution of genetic risk factors to the development
of cognitive decline in patients with cerebral small vessel
disease (cSVD). 103 subjects with cSVD and having cognitive
impairmentand96cognitivenormalcontrolsubjectswithSVD
wererecruited.Demographicandclinicaldetailsofthesubjects
were recorded. Based on brain MRI studies subjects were
categorized for radiological severity using Fazekas grading.
NIMHANSNeuropsychologicalbatterytest(NNBP)andHindi
mentalstateexaminationtest(HMSE)scoreswererecordedfor
cognitive function assessment. No significant correlation was
observedbetweenradiologicalseverityandcognitivefunction
test score. Genotyping for angiotensin converting enzyme
Insertion/deletion (ACE I/D) and aldosterone synthase gene
(CYP11B2 -344 T/C) gene polymorphisms were studied using
directPCRandRFLPmethods.ResultsofgenotypingforACE
I/D and CYP11B2 -344T/C gene polymorphism in cases and
controlshowthatthesepolymorphismsarenotassociatedwith
cognitivedysfunctionincSVD.
Annual Report
7.
2013-14
Factors determining course and prognosis in
tuberculous meningitis. Cognitive functions
in idiopathic Parkinsonism. Investigators: Dr.
Sikandar Adwani, Dr. SR Chandra
Patients with culture positive TBM, multiple co-morbidities,
extremes of age and intermittent therapy , drug toxicity
necessitatingshifttosubstituteregimesandpresenceoflesions
inthecisternalspacesadverselyinfluencedtheoutcome.Most
personswithparkinsonismhadexecutivefunctiondefectbutit
wasnotinfluencedbythesideofonsetofthedisease.
EDTA-Vacutainertubes.Thecollectedbloodsamplesarestored
asperprotocolinafridgeandaretransferredtoIISc,Bangalore.
Some of the families have been explained about the research
underway and requested to bring the rest of the members at
follow up so as to collect the samples from them also. So far,
collectedbloodsamplesfrom400individualsfrom119families
have been collected. For many families, blood samples need
tobecollectedfromoneorbothparentsandotheraffectedor
normalsiblings.Tillnow50familieshavebeentested.
13.
Sleep architecture and disorders in patients with
Juvenile Myoclonic Epilepsy (JME) syndrome:
A polysomnographic (PSG) study. Investigators:
Dr. Sanjib Sinha, Dr. P Satishchandra, Dr. AB
Taly (Funding by DST)
8.
Glucocerebrosidase mutation in Parkinson’s
disease -3 years. Investigators: Dr. Pramod
Kumar Pal, Dr. Ravi Yadav (Funding by DBT)
9.
Genetics of movement disorders: Genotypephenotype correlates in ataxias and Huntington’s
disease. Investigator: Dr. Pramod Kumar Pal
(Funding by ICMR)
10.
Modulation of clinical features and cortical
excitability following low frequency repetitive
transcranial magnetic stimulation in Writer’s
Cramp
and
Primary
Writing
Tremor.
Investigators: Dr. Pramod Kumar Pal, Dr. Ravi
Yadav (Funding by Others)
11.
Gray and white matter correlates of REM sleep
behaviour disorder and psychosis in Parkinson’s
disease. Investigator: Dr. Pramod Kumar Pal
(Funding by ICMR)
12.
Detection of known and new genetic mutations
and phenotype-genotype correlation in Wilson’s
disease from south Indian cohort. Investigators:
Dr. Sanjib Sinha, Dr. AB Taly (in association with
IISc, Bangalore—funding by DBT)
14.
Automated
portable
epilepsy-EEG
system
with Axxonet systems. Investigators: Dr. P
Satishchandra, Dr. S. Sinha, in association with
Axxonet Technologies, Bangalore (Funding by
DBT)
PatientswithWilson’sdisease,whoarebeingfollowedupatthe
Neurologyout-patientservicesatNIMHANS,arebeingrecruited
for the study. The recruits undergo a detailed evaluation of
history, physical examination and relevant tests. Thepatients
alsoundergoMRIofthebrainasperWilson’sdiseaseprotocol,
biochemicaltestsforWilson’sdiseaselikeserumcopper,serum
ceruloplasmin,and24hoursurinarycopper.Afterobtainingan
informedconsentfromthepatientsandtheirfamilymembers,
3-5mlofbloodsamplearecollectedfromeachoftheparents
(ifavailable),normalandaffectedsiblings(ifavailable)inNa-
15.
Development of Intra-operative ECoG and depth
recording electrodes for surgery for refractory
epilepsy - part 1. Investigators: Dr. S Sinha, Dr. P
Satishchandra (Funding by DEBEL/SBMT)
16.
Towards identification of novel genes for reflex
epilepsy (hot water epilepsy) triggered by tactile
and temperature stimuli. Investigators: Dr. A
Anand, JNCASR, Dr. S Sinha, Dr. P Satishchandra
(Funding by ICMR)
ThesubjectsofJMEsyndromeandcontrolshavebeenrecruited
from the Neurology out-patient and emergency services, and
screening block, Department of Neurology, NIMHANS. The
recruits were selected after a detailed evaluation of history
and a physical examination. All the recruits were subjected to
standardizedsleepquestionnairestorefinetheselectionprocess;
namely the Epworth Sleepiness Scale, the Pittsburgh Sleep
QualityIndexandNCSDQ.Thesubjectswerethenmadetogo
throughanEEGandaPSGonthesamedayandtheyunderwent
an MRI brain subsequently. The drug naïve patients were
subjectedtothePSGonthesamedayofassessmentandwere
started on suitable medication the very next day. A total of 90
subjectshavebeenrecruitedsofar:PatientswithJME-drugnaïve
-30;PatientswithJMEonvalproate–30;andHealthycontrols
–30.Tilldate,90polysomnographies,88scalp-EEGand75MRI
(brain)havebeendonealongwithphenotypicassessment.
Annual Report
17.
Genetic Analysis of the Beta-glucocerebrosidase
gene in South Indian patients with Parkinson’s
disease. Investigators: Prof. Arun Kumar,
IISc, Prof. Pramod Kumar Pal, Dr. Ravi Yadav
(Funding by DBT)
In this project, the investigators intend to study the GBA
mutations in Indian patients with Parkinson’s disease. More
than300patientandcontrolsampleshavebeencollected.The
analysisisstillongoing.
18.
The role of metals in the etio-pathogenesis of
Parkinson’s disease. Investigators: Dr. Pramod
Kumar Pal, Dr. Rita Christopher, Dr. Ravi Yadav,
Dr. Rose Dawn Bharath, Dr. Jitender Saini
(Funding by DBT)
Thisisamulti-institutionalprojectaimedatstudyingtherole
ofmetalsintheetiopathogenesisofParkinson’sdiseaseandthe
objective is to compare the possible disease markers between
a cohort of patients with Idiopathic Parkinson’s Disease (PD)
andageandgender-matchedhealthycontrols:(i)Serumlevels
ofmetalsincludingFe,Cu,Zn,Pb,Mg,Mn,etc.,(ii)Markersof
metabolitesofoxidativestressinserum,and(iii)Iron/metal
depositioninthebrainasdetectedbyadvancedMRItechniques.
100 patients with Parkinson’s disease and 85 controls were
recruitedtillMarch2014.Eachpatient’smotorandnon-motor
symptoms were evaluated using different Parkinson’s disease
ratingscales.Markersofoxidativestresshavebeenstudiedby
theassayofferricreducingabilityofplasma(FRAP)andserum
malondialdehyde.Patientshadhigherserummalondialdehyde
levels compared to controls. Patients who had MRI analysis
for detection of iron/metal deposition in the brain showed
significant atrophy mainly in the caudate nucleus, thalamus
andcingulategyrus.
19.
Exploring subclinical cerebellar dysfunction in
patients with essential tremor, primary writing
tremor and Writer’s cramp by quantitative
characterization of ocular movements and eye –
hand coordination and advanced neuroimaging
techniques. Investigators: Dr. Pramod Kumar
Pal, Dr. K Thennarasu, Dr. Jitender Saini, Dr.
Ravi Yadav (Funding by DBT)
20. Spectrum of autoantibody expression in
generalized
myasthenia
gravis:
Clinical
phenotype and immunological correlation.
2013-14
Investigators: Dr Madhu Nagappa, Dr. Anita
Mahadevan, Dr. Shripad Patil, Dr. AB Taly
Myasthenia gravis (MG) is an immune mediated disorder
characterized by fatigable weakness of skeletal muscles.
Heterogeneityintheageatonset,diseaseexpression,associated
thymichistology,severityofmuscleinvolvementandresponse
to treatment in MG are recognised. This depends on the
expression patterns of specific autoantibodies which forms
thebasisofclassificationofMGintoimmunologicallydistinct
subtypes. Majority of patients are positive for antibodies to
acetylcholine receptor. Several other auto-antibodies are
expressedinthesepatientswith‘seronegative’MG.
The proposed study will investigate the auto-antibody profile
inpatientswithgeneralizedMG,includingantibodiestoAChR,
MUSK, titin, and ryanodine receptor. Classification based on
theauto-antibodystatuswillnotonlyhelptodefinetheclinical
subsetsofMGinthecohort,butalsohelpintailoringtherapy
andpredictingtheprognosis.
21.
Genetics and Epilepsy.
Satishchandra
Investigator:
Dr.
P
Following projects are being undertaken in collaboration
withtheMolecularGeneticsDepartmentofJawaharlalNehru
Center for Advanced Studies at Bangalore: After getting two
lociforthisuniquetypeofreflexepilepsy;HotwaterEpilepsy
– one Chromosone 10q21-23 and another at 4q 24-28. The
investigatorsarecontinuingthenextphaseofGenehuntingin
theseregions.Theyhaverecentlyidentifiedgene–Glutamate
Transporter gene for the causation of Hot-Water epilepsy on
chromosome9q.Furtherworkisgoingonthisdirection.
Pharamaco-geneticsisanupcomingfieldinepilepsy.Theyhave
startedtheresearchworkinlookingat‘PharmacoGeneticsof
IntractableSeizures’and‘GeneticsofRefractorinessofEpilepsy’
incollaborationwithJNCASR,BangaloreandInstituteofBio
Informatics,Bangalore.FirstpaperonMedicalTemporalLobe
EpilepsyGeneticProfiling–isalreadyin.
22. Pregnancy and Epilepsy. Investigator: Dr. P
Satishchandra
Thisisoneofthecommonlydebatedproblems.Becauseofthe
problemsinvolvedinthisarea,andsparseliteratureespecially
fromIndia,theinvestigatorsarelookingattheteratogenicityof
AEDs,andsuccessfulpreganancyamongepileptics.
Annual Report
2013-14
23. Reflex Epilepsy. Investigator: Dr. P Satishchandra
Reflex epilepsies are interesting variety of seizures/epilepsy
classifiedasaseparategroupundertheproposedInternational
classification of seizures/epilepsy. These could be used as a
modelforfurtherunderstandingthemechanismofepilepsyin
general.Henceastudyhasbeenundertakentoevaluatethese
reflexseizuresbyAutonomicfunctiontests,Electrophysiological
followedbyInterIctal/ictalSPECTscan.Thiswouldhelpinthe
processofunderstandingthepathophysiologicalmechanisms.
24. Autonomic Nervous system and Hot water
epilepsy. Investigator: Dr. P Satishchandra
Hot water epilepsy an interesting variety of reflex seizures
is being studied for more than two decades. Currently, the
investigators are exploring the role of Autonomic Nervous
system and HWE, with a hope that this must be playing an
importantroleinitscausation.
25. CJD Registry. Investigator: Dr. P Satishchandra
This is ongoing project in collaboration with the Department of
NeuropathologyatNIMHANS.Initiallyitwasfundedbutnowitis
anon-fundedproject.Thisregistryincludesprobableanddefinite
CJDs confirmed histopathologically. The investigators are also
partof‘SurveillanceofCJDinIndia’undertheMinistryofHealth.
26. HIV and Nervous system. Investigator: Dr. P
Satishchandra
Thisisanongoingproject.Sofar,morethan1500patientswith
NeuroAIDS/HIVinfectionarebeingevaluatedatNIMHANS.
Nearly 140 autopsies have been carried out in collaboration
with the Department of Neuropathology. These materials are
beingprocessedandanalyzedtounderstandvariousOIs.The
dataonCryptococcalmeningitis,andworkonToxoplasmosis,
PMLhavealreadybeenpublished.CNSTuberculosisassociated
withHIVinfectionisbeingstudied.Theinvestigatorshavejust
completed a non-funded study of ‘An approach to focal brain
lesions associated with HIV clade C infection’. Interesting
associationwithHIVandSino-Venousthrombosis,Lymphoma
andNeurosypilishasbeenestablished.
Another interesting area is ‘Neuro IRIS’. This is a new
area yet to be understood among the scientific community.
The investigators are finding cases of patients with their
condition worsening on HAART with very high CD4 cell
count – a paradoxical reaction. Cases of TBM, Tuberculoma,
CryptococcusMeningitis,PMLetchavebeenfound.Theproject
isbeingtakenupthisyearasanewinitiativeforfurtherstudy.
27.
Resting state fMRI in hot water epilepsy.
Investigators: Dr. Raghavendra, Dr. Sanjib Sinha,
Frequencyofseizurescouldbeanimportantfactorwhichcan
alter the properties of functional brain networks. To explore
this possibility, the investigators applied graph theoretical
approachtorestingstatefunctionalMRInetworksin36drug
naïvepatientswithhotwaterepilepsy(HWE)and18matched
healthycontrolsavoidingpotentialconfoundsofanti-epileptic
drugs. Seed-based connectivity analysis revealed that HWE
with frequent seizures had increased connectivity within the
medial temporal structures and several regions with poor
connectivityeveninvolvingthedefaultmodenetwork(DMN)
in comparison with the infrequent seizure group. Though the
infrequent seizure group was similar to the healthy controls
inmajorityofseedsandhadpreserveddefaultmodenetwork
connectivity, some seeds in the somato sensory cortices,
frontallobes,superiortemporalandinsularevealedincreased
connectivity. Patients with infrequent seizures have focal
network abnormalities, preserved DMN and medial temporal
lobeprobablyreflectingdirectfunctionofdiseasehighlyunlike
patients with frequent seizures. While features like diffuse
network abnormalities, involvement of the DMN and medial
temporallobestructuresshouldraisearedflagalertforanearly
diagnosisofrefractoryepilepsy,itisencouragingtoinferthat
earlyandadequateseizurecontrolcanpotentiallyinterruptthe
viciouscycleofseizuresandprogressivenetworkdisruption.
28. White matter abnormalities in Wilson’s disease:
A clinical and serial MRI correlative study. Dr.
Anish L. Guides: Dr. AB Taly, Dr. Sanjib Sinha,
Dr. Jitender Saini
This study analyzed 35 patients with Wilson’s disease with
brain MRI with diffusion tensor imaging (DTI). Nineteen
patients with leucoencephalopathy among the cohort were
compared with 16 patients without leucoencephalopathy.
These patients were followed up for a mean duration of one
year and reimaged. The patients with leucoencephalopathy
had more severe illness and disability at baseline though the
clinical features were similar except for higher prevalence of
seizuresamongthosewithleucoencephalopathy.Thepatients
with leucoencephalopathy had severe MRI scores. Their DTI
showedincreasedMD,RDandADwithdecreasedFAandpoor
therapeuticresponseduringthefollow-up.
Annual Report
29. Clinico-pathological correlation of peripheral
neuropathy in the elderly. Dr. Anish L. Guides:
Dr. AB Taly, Dr. Anita Mahadevan, Dr. Madhu N
One-hundred elderly subjects with peripheral neuropathy who
underwentnervebiopsy(2002-2011)wereanalysedforutilityof
nervebiopsyinprovidingdiagnostic,therapeuticorprognostic
information that aids clinical management. Nerve biopsy
was ‘diagnostic’ in 24, and ‘essential’/ ‘helpful’ in therapeutic
managementin81.Itconfirmedpre-biopsydiagnosisin29,and
offerednewdiagnosisin25.Ahigheryieldofbiopsywasnotedin
subjectswithasymmetric/multiplemononeuropathycompared
tosymmetricneuropathies(32.7%vs17.7%).Nervebiopsyaided
in detection of potentially treatable disorders and influenced
patientmanagementin81%ofelderlysubjectswithneuropathy,
includingasubsetwithoutapre-biopsyetiologicaldiagnosis.
2013-14
yieldofvarioustestswas:Neostigminetest55%,Icepacktest
89.4%,RNStest(Orbicularisoculi)40%,andAChRantibodies
55%. CT thorax was normal in 19/19 patients. SFEMG was
abnormal in all patients (Frontalis 77.8%, Orbicularis oculi
72.2%).16/20patientswerestartedonPrednisolone(0.7mg/
kg).Duringfollow-up(4-12monthintervals),repeatSFEMGof
themoreabnormalfacialmuscle(2-5studies/patient)showed
normalizationofjitterat8-15monthsafterstartingtreatment
– unlike reported in literature. 4/5 of these patients were on
regular treatment. Patients with poor compliance tended to
have relapses and abnormal SFEMG. In three other patients,
SFEMGafterbecomingnormalworsenedagain.
31.
Neurologic sequelae of neonatal hypoglycemic
injury: A clinical, Electroencephalographic and
imaging study. Dr. Dipesh Pimpale. Guides: Dr.
Bindu PS, Dr. Rose Dawn Bharath
Neonatalhypoglycemiaresultsinvariousformsofneurological
disability in children which include mental retardation,
visualimpairment,autisticspectrumdisordersandrefractory
epilepsy.Acharacteristicpatternofparietooccipitalgliosison
magneticresonanceimagingoftenpointstothediagnosis.This
study intends to analyse the different clinical manifestations,
EEG features and magnetic resonance imaging findings in a
cohortofchildrenwithhistoryofneonatalhypoglycemia.This
studyisexpectedtoderiveadataontheneurologicaldisability
causedbyneonatalhypoglycemiawhichmaybeusedforbetter
preventivemeasures.
32. Leukoencephalopathies
in
childhood:
A
phenotypic and magnetic resonance imaging
study. Dr. Dipesh Pimpale. Guides: Dr. Bindu PS,
Clinico-Pathological Correlation of peripheral neuropathy in the elderly
A-C: Definite Vasculitis, D.E: Inflammatory demyelinating polyneuropathy, F-H:
Leprous neuritis, I,J: Ischemic Neuropathy
30. Ocular myasthenia gravis: Clinical evaluation,
treatment response and prediction of outcome
by single fiber electromyography. Dr. Devaraddi
Navalli. Guide: Dr. M Veerendrakumar
Twentyadultpatientswithsuspectedocularmyasthenia(OMG)
were evaluated (October 2010 - January 2013). Diagnostic
Leukoencephalopathies in childhood encompass a wide
spectrum of disorders in which predominantly or exclusively
white matter is affected and usually lead to progressive
intellectual and neurological deterioration. Inspite of a high
incidenceofleukoencephalopathiesinSouthIndia,thereareno
systematicstudiesonthissubjectinIndiancontexttillnow.This
studyaimstoanalysethephenotypicandmagneticresonance
imagingcharacteristicsofvariousleukoencepahlopathiesseen
inchildren.
Thedataisexpectedtogiveanoverviewofthedifferenttypes
of leukoencephalopathies seen in children from South India
whichmaybeusefulintheearlydiagnosis,prognosticationand
geneticcounselinginthesechildren.
Annual Report
2013-14
33. Phenotypic and genotypic correlation of POLG
related disorders. Dr. Chetan Kashinkunti.
Guides: Dr. Bindu PS, Dr. Gayathri N, Dr.
Thangaraj
POLG (Polymerase gamma) mutation has recently evolved as
oneofthemostcommoncauseofmitochondrialdysfunction.
Itpresentswithawiderangeofphenotypes,complicatingthe
scenarioforaclinician.Thiscallsforgeneticvalidationofthe
suspected phenotype to affirmatively diagnose POLG related
disorders.Inatertiarysetupsuchasours,withmitochondrial
research growing fast, it would be one more step forward, to
studythegenotypicandphenotypiccorrelatesofPOLG related
disorders.
Investigator: Dr. R Ravikumar (Collaborative
project with IOB, Bangalore and SDS TRC & Rajiv
Gandhi Institute of Chest Diseases)
7.
Proteomic analysis of chronic and acute
meningitis using mass spectrometry-based
approach. Investigators: Dr. R Ravikumar
(Collaborative project with IOB, Bangalore)
8.
Comparison between SACETT and SETT on the
incidence of VAP in Neuro ICU. Investigators: Dr.
Sri Ganesh, Dr. R Ravikumar, Dr. Veena Kumari HB
9.
Confirmation and characterization of HA-MRSA
and CA-MRSA. Investigators: Dr. Veena Kumari
HB, Dr. Nagarathna S (Funding by ICMR)
10.
Neuroleptospirosis-study
of
microbiological
and clinical aspects-viral meningitis, Is it
neuroleptospirosis? Investigators: Dr. Nagarathna
S, Dr. Veena Kumari HB (Funding by ICMR)
11.
Neurobrucellosis-microbiological and clinical
evaluation. Investigators: Dr. Nagarathna S, Dr.
Veena Kumari HB (Funding by ICMR)
Neuromicrobiology
1.
2.
Whole
genome
sequencing
analysis
of
Mycobacterium tuberculosis clinical isolates
from extra pulmonary tuberculosis patients.
Investigators: Dr. R Ravikumar, Dr. P
Satishchandra, Dr. Keshava Prasad, Dr. Akhilesh
Pandey (Funding by DBT)
Genomic and proteomic analysis of chronic
meningitis. Investigators: Dr. R Ravikumar
(Funding by DBT)
Neuropathology
3.
Etiopathogenesis
of
chronic
meningitis:
Biochemical
analysis
and
molecular
characterization of M. tuberculosis and C.
neoformans in CSF of patients. Investigators: Dr.
R Ravikumar (Funding by ICMR)
1.
4.
Phenotypic
identification
and
molecular
characterization of blandm-1gene in multidrug
resistant Gram negative bacilli isolated from
clinical and environmental samples in a tertiary
neurocare centre. Investigator: Dr. R Ravikumar
5.
Development of novel antimicrobial agents to
overcome microbial resistance. Investigator:
Dr. R Ravikumar (Collaboration with JNCASR,
Bangalore)
The different aspects of glioblastoma pathogenesis which are
being studied include: Role of epigenetics in glioblastoma
development: Genome-wide methylation profiling of
glioblastoma, deregulated MicroRNAs in glioblastoma;
Identification of molecular signatures specific to tumor
infiltrating region relative to tumor core using Magnetic
Resonance Image (MRI) guided site specific biopsies;
Histology-based evaluation of novel glioblastoma markers
by a high-throughput methodology to establish the utility of
biomarkerdiscovery.
6.
Identification of mycobacterium tuberculosis
antigens of diagnostic potential in body fluids
using high resolution mass spectrometry.
2.
Multi-institutional-network
programme
in
molecular Neuro-oncology. Investigators: Dr.
Vani Santosh, Dr. Yasha TC, Dr. Arivazhagan, Dr.
Paritosh Pandey, Dr. Thennarasu, Dr. Rose Dawn
(Funding by DBT)
Blood safety. Investigator: Dr. Sundar Periyavan
(Funding by Karnataka State AIDS Control
Society)
Annual Report
3.
Blood component separation unit and optimising
availability of blood use. Investigator: Dr. Sundar
Periyavan (Funding by Karnataka State AIDS
Control Society)
4.
Molecular and histological analysis of neurological
disorders associated with Mitochondrial DNA
mutations. Investigators: Dr. Gayathri N, Dr. AB
Taly, Dr. Yasha TC, Dr. Nalini A (Funding by DBT)
Patients with clinical and magnetic resonance imaging
(brainstem, cerebellar basal and ganglia involvement and
bilateral symmetrical hypertrophic olivary degeneration)
evidence of Leighs syndrome were analysed. Mutation in the
SURF1isoneofthemostcommonnuclearmutationsassociated
with Leigh syndrome and cytochrome c oxidase deficiency.
The study included four patients with Leigh syndrome and
SURF1mutationsidentifiedfromacohortof25childrenwith
Leighsyndromeseenoveraperiodofsixyears(2006–2012).
SequencingofthecompletemitochondrialgenomeandSURF1
wascarriedout.Sequencingoftheentiremitochondrialgenome
didnotrevealanyknownornovelvariationsinthesepatients.
SURF1 sequencing revealed previously unreported mutations
inall.Twopatientshadsamemutationnamelyfourbasepair
(TAAA)deletion(c531-533del).Insertionofcytosinec152Cins
wasseeninonepatientwhileoneshowedamissensemutation
G180R in SURF1. Thus, SURF1 analysis identified previously
unreportedmutationsinallthepatients.
5.
Protein aggregate myopathies- A clinical,
pathological, immunohistochemical, molecular
genetics
and
proteomic
investigation.
Investigators: Dr. Gayathri N, Dr. Nalini A
(Funding by DST)
ProteinAggregateMyopathies(PAM)areanemergingsubgroup
ofcongenitalmyopathies,whicharemarkedbyaccumulation
of diverse proteins within the muscle fibre as a morphologic
hallmark,whichnowcomprisediverseentities.PAMaffectthe
skeletalmuscleshowever,cardiacmusclemayalsobeaffected
occasionally as in Nemaline myopathy and desmin related
myoptahies. Most of the disorders share generalized clinical
andpathologicalfeatures,suchasmuscleweakness,hypotonia,
reduced muscle mass, defective mitochondria, excessive
proteinaccumulation,etc.However,variabilityinthefeatures
is also observed even amongst different alleles of the same
protein. Amongst the several proteins known in the skeletal
muscletissue,proteinssuchasmyosin,actin,desmin,vimentin
aggregatecausingdiversedisorders.Musclebiopsiesfromfive
2013-14
cases with age ranging from 6 to 58 years analysed showed
aggregates of material on MGT staining which on oxidative
stains showed absence of enzyme activity in those regions.
Detailedworkupforimmunohistochemistrytocategorizethe
typeofproteinaggregatesandelectronmicroscopytostudythe
morphological appearance of the aggregates was carried out.
TwocaseswithaprobablediagnosisofMyosinopathyarebeing
analysed.
2D gel electrophoreses carried out in one case of Nemaline
rod myopathy identified two spots not seen in the normal
muscle. The molecular weight corresponds to troponin and
actin. Further confirmation by mass spectrometric analysis is
underway.
6.
Studies on the seasonal variation in the
ultrastructure of the renal sex segment of
the lizard, Mubuya carinata. Investigators:
Dr. M Bhagya, University of Mysore, Dr. BK
Chandrasekhar Sagar (Funding by UGC)
The information on Renal Sex Segment (RSS) which is an
important accessory sexual organ of squamate reptiles is
scarceandfragmentary.ThesecretionsoftheRSSofthemale
lizard might have a role in the sustenance and maintenance
of spermatozoa in the female genital tract. There is a need
for understanding the structure and function of the RSS
and other organs including brain during breeding and non
breedingseasonsinsquamatereptiles.Thepresentstudyhas
been designed to examine ultrastructural seasonal variations
of the cells and sexual granules, in terms of development,
maintenanceandregressioncorrelatedwithplasmaandrogen
concentration in the lizard Mubuya carinata. This study
will provide comparative data for expanding knowledge of
the ultrastructural variation of the RSS in male squamates,
particularly lizards. The chemical characterization of the RSS
secretionswillbeofgreatevolutionarysignificance.
7.
Genomic proteomic and transcriptomic profiling
of tuberculous meningitis. Investigators: Dr.
Akhilesh Pandey, Institute of Bioinformatics,
Bangalore, Dr. Keshav Prasad, Institute of
Bioinformatics, Bangalore, Dr. SK Shankar, Dr.
Anita Mahadevan (Funding by DBT)
The investigators used a quantitative proteomics approach to
discoverproteinbiomarkersfortuberculousmeningitis.Protein
isolationfrompathologicallyprovenautopsycasesofTBMand
ageandsexmatchedbraintissuesofheadinjurycasesascontrols
Annual Report
2013-14
weresubjectedtoquantitativeproteomicanalysisusingiTRAQ
labelingandLC-MS/MSanalysisofSCXfractionatedpeptideson
Agilent’saccuratemassQTOFmassspectrometer.Bothknown
and novel differentially regulated molecules were identified.
Those described previously included signal-regulatory protein
alpha(SIRPA)andproteindisulfideisomerasefamilyA,member
6 (PDIA6), which have been shown to be overexpressed at the
mRNAlevelintuberculousmeningitis.Thenoveloverexpressed
proteinsidentifiedinthestudyincludedamphiphysin(AMPH)
and neurofascin (NFASC) while ferritin light chain (FTL)
was found to be downregulated in TBM. The investigators
validated amphiphysin, neurofascin and ferritin light chain
usingimmunohistochemistrywhichconfirmedtheirdifferential
expressionintuberculousmeningitis.Overall,thedataprovides
insightsintothehostresponseintuberculousmeningitisatthe
molecular level in addition to providing candidate diagnostic
biomarkersfortuberculousmeningitis.
8.
Toxoplasma gondii genotypes in cerebral and
extracerebral toxoplasmosis. Investigators: Dr.
RS Jayshree, Professor, Dept. of Microbiology,
KIDWAI Memorial Institute of Oncology,
Bangalore, Dr. SK Shankar, Dr. Anita Mahadevan
(Funding by ICMR)
The objective of the study is to investigate the genotypes
of Toxoplasma gondii (T.gondii) in two groups of
immunocompromised patients viz. (a) HIV positive patients
with a confirmed diagnosis of Toxoplasma Encephalitis and
(b)PatientswithHematologicalMalignanciespresentingwith
extracerebraltoxoplasmosis.MultilocusnestedPCR(MnPCR)
forgenotypingT.gondii wasperformedfrombraintissuesfrom
toxoplasma lesions from 25 autopsied cases. The PCR results
arebeinganalysed.
9.
Characterization of host response to C.
neoformans through quantitative proteomic
analysis of cryptococcal meningitis co-infected
with HIV infection. Investigators: Dr. Akhilesh
Pandey, Institute of Bioinformatics, Bangalore,
Dr. Keshav Prasad, Institute of Bioinformatics,
Bangalore, Dr. SK Shankar, Dr. Anita Mahadevan
(Funding by DBT)
The investigators performed an iTRAQ based comparative
proteomeprofilingoffivefrontallobebraintissueseach,from
cryptococcal meningitis patients and age and sex matched
controls.
Theyidentified273proteinstobedifferentiallyexpressed(≥2
fold)fromatotalof3,423humanproteins.Theyfoundproteins
involved in immune response and signal transduction to be
differentiallyexpressedinresponsetocryptococcalinfectionin
humanbrain.ProteinslikeICAM1,CAV1,ACTA2andHMMR
protein were upregulated in infection. Increase in Fibrinogen
betachain(FGB)proteinandfibrinogendegradationproducts
observed in CSF is essential for altering the blood brain
barrier. Complement proteins such as C1QB and C1QC and
majorhistocompatibility proteins are upregulated and have
a role in host protectionImmunohistochemistry (IHC)-based
validation was performed for five proteins, three of which
wererelativelyoverexpressedincryptococcalmeningitisbrain
tissues-Caveolin1,[caveolaeprotein,22kDa,(CAV1)],Major
histocompatibility complex, class I, B (HLA-B), Actin, [aortic
smoothmuscle(ACTA2)],andtwoshowedreducedexpression
in cryptococcal meningitis brain tissues - Peripheral myelin
protein2(PMP2),andalpha-crystallinBchain(CRYAB).
10.
Host response profile of human brain proteome
in toxoplasma encephalitis. Investigators: Dr.
Akhilesh Pandey, Institute of Bioinformatics,
Anita Mahadevan,(Funding by DBT)
In comparison of frontal lobe of the brain from patients
diagnosedwithtoxoplasmaencephalitistocontrolbraintissues,
3,496 proteins were identified, out of which 607 proteins
were differentially expressed (≥ 1.5-fold). The investigators
validated differential expression of three proteins through
immunohistochemistry, confirmed to be consistent with
mass spectrometry results. Pathway analysis of differentially
expressedproteinsindicatedderegulationofpathwaysinvolved
in antigen processing, immune response, neuronal growth,
neurotransmittertransportandenergymetabolism.
Global quantitative proteomic approach provided the
comparativeproteomeprofileofbraintissuesfromtoxoplasma
encephalitispatients.Differentiallyexpressedproteinsincluded
several new proteins in the context of T. gondii infection,
to be further investigated to enhance the understanding of
pathogenesisintoxoplasmaencephalitis.
11.
Understanding mechanism of HIV- associated
opportunistic infections of the CNS. Investigators:
Dr. Akhilesh Pandey, Institute of Bioinformatics,
Annual Report
2013-14
Anita Mahadevan (Funding by DBT)
Theinvestigatorscarriedoutextensivegenomicandproteomic
analysis of brain tissues from HIV-associated opportunistic
infections of the CNS including cryptococcal meningitis,
tuberculous meningitis and toxoplasma encephalitis. Brain
tissues from patients of these diseases and corresponding
age-sex matched controls were obtained from archives of the
Human Brain Bank at NIMHANS. iTRAQ-based quantitative
proteomics strategy using high-resolution Fourier transform
massspectrometrywasemployedtoidentifytheproteinswhose
expression is altered in the brain tissues in response to these
diseaseswhencomparedtothatofcontrolbrain.Differentially
expressedproteinswereclassifiedbasedonbiologicalprocesses
andmolecularfunctionsusingGeneOntology(GO).Functional
and pathway analysis using GeneSpring revealed several
differentiallyregulatedproteinsinvolvedinbloodbrainbarrier
breach,immuneresponse,calciumsignaling,neurotransmitter
release, neuronal degeneration, energy metabolism and
regulationofactincytoskeletonpathway.
12.
Establishment of skin punch biopsy for evaluation
of peripheral neuropathies. Investigators: Dr.
Anita Mahadevan, Dr. P Satishchandra, Dr. AB
Taly, Dr. SK Shankar (Funding by DBT)
This is a pilot project aiming to establish the technique of
skin punch biopsy as a relatively non-invasive technique
for diagnosis of small fibre neuropathies. Normative data of
intraepidermal nerve fibre density will be collected from skin
biopsiesfromcontrolatdifferentagegroups.
Skin biopsies from controls (collected postmortem), patients
with neuropathies of varied etiology (hereditary sensory
autonomic neuropathy, Guillain Barre Syndrome with
autonomicinvolvement,smallfibreneuropathyandHIV/AIDS)
have been collected as per established protocol after taking
informedconsentofpatients/closerelativeswhencollectedat
autopsy.Biopsiesweretakenfromthreestandardsitesinthe
lower limb. Cryoprotected samples have been cryoprotected
according to the guidelines of the European Federation
of Neurological Societies (EFNS), and immunostained by
indirect immunoperoxidase with panaxonal marker PGP 9.5
and intreaepidermal nerve fibre density quantitated on serial
sections under brighfield microscopy. Determining normative
data in the patient population is in progress. The technique
has helped in diagnosis of hereditary sensory autonomic
neuropathies in children thereby avoiding invasive nerve
biopsiesinthesechildrenwithitsattendantcomplications.
Normal IENFD in control (3.8/mm)
13.
Reduced IENFD in control (2.0/mm) in
patient with small fibre neuropathy
Role of CNS opportunistic infections in
subsequent development of HIV Encephalitis.
Investigators: Dr. Carlos Pardo, John Hopkins
University, USA, Dr. SK Shankar, Dr. Anita
Mahadevan, Dr. P Satishchandra (Funding by
NIH)
Theprojectaimedatdeterminingextentofglialactivationand
neuronal injury in HIV patients with opportunistic infections
such as Toxoplasma encephalitis, cryptococcal meningitis
and tuberculous meningitis. Quantitative distribution of
HIV-1 viruses within different anatomical compartments in
brain comparison with non-neural compartments (lymph
node, spleen) is under study by estimation of pro-viral DNA
copy number by real-time PCR (collaboration with Dr.
Ranga Uday Kumar, JNCASR, Bangalore) and determine
viral compartmentalization in brain, lymph node and spleen.
All the infections were of subtype C and in some cases
genetic compartmentalization among brain and non-brain
sequenceswereseen.Insomeofthecompartments,switchin
receptor usage from R5 to R5/X4 or X4 was found. Pro-viral
DNA concentration in frontal cortex was highest and may
correlate with development of neurolocognitive impairment
in these individuals. In addition, proinflammatory cytokines,
chemokinesandTh1/Th2/Th17cytokinesinCSFwasevaluated
with BD Cytometric Bead assay to understand pathobiology.
Using an indigenously developed “syndrome evaluation
system”–DNAchip(M/sXcytonDiagnostics)co-existenceof
VZV,HSV,CMV, JCV,was found inpathologically confirmed
cases of cerebral toxoplasmosis, crytpococcal meningitis and
tuberculosisreflectingco-existenceofotherpathogens.
14.
Subregional cytoarchitectural changes and cell
cycle dysregulation in the hippocampus in patients
with temporal lobe epilepsy. Investigators: Dr.
Lily Pal, Dept. of Pathology, SGPGI, Lucknow,
Dr. SK Shankar, Dr. P Satishchandra (Funding by
DST)
Hippocampal Sclerosis (HS), also called Ammon’s horn
sclerosisisthemostcommonpathologicalsubstrateinTLEwith
Annual Report
2013-14
characteristicpatternofneuronallossinprimarilyinCA1and
hilarsubfields.Pathologicfindingsmaybewidespreadinsevere
caseswithrelativesparingofCA2region.Neuronaldegeneration
isaccompaniedbyastrogliosis,lossofmossyfibresinthehilus
and mossy fibre sprouts into the supragranular layer of the
dentate gyrus. Another frequently associated phenomenon is
granule cell migration into the supragranular layer. It is not
clear whether granule cell proliferation and dispersion has
any relationship with the degree of neuronal loss and gliosis.
It is known that p75NTR induces neuronal apoptosis in TLE.
However, its association with granule cell proliferation and
migration into molecular layer of dentate gyrus is unclear.
In this study, the investigators plan to determine neuronal
density in inner and outer layer of dentate gyrus, undertsand
pattern of granule cell dispersion and its correlation (if any)
withdegreeofneuronalloss,estimateMIB1countingranular
andsupragranularzone(doesneurogenesisoccurinresponse
to therapy?) and study role of p75 NTR expression (is there
anyrelationshipexistbetween p75NTRexpressionandabove
parameters?)
16.
15.
Proteinmisfoldingleadingtoaggregationiswidelyimplicated
in the pathologies of such late-onset diseases as Alzheimer’s,
Parkinson’s and Huntington’s diseases, amyotrophic lateral
sclerosis, type II diabetes and many other systemic and
localisedamyloidoses, which are associated with degeneration
processes. They all arise from a generic accumulation in the
body of unnecessary and potentially hazardous proteinaceous
amyloidproducts.InAlzheimer’sdiseasetheamyloidplaques
formed from Aβ peptide spread through hippocampus and
corticalareasofthebrain.InParkinson’sdiseaseα-synuclein
formstheamyloiddepositsknownasLewybodiesinsubstantia
nigra. The investigators have shown that inflammation and
inflammatory protein S100A9 in particular, whose level
significantlyincreasedduringinflammation,maysignificantly
acceleratetheamyloidcascade,seedingtheamyloidsofmajor
proteinaceousdenominatorofthecorrespondingdisease.
Development of the human auditory cortex.
Investigators: Dr. Soumya Iyengar, Additional
Professor and Scientist V, NBRC, Manesar,
Gurgaon, Dr. SK Shankar, Dr. Anita Mahadevan
The investigators had earlier found that axons in all layers
of the auditory cortex were immunoreactive for heavy and
medium chain neurofilaments by 25 GW and the density of
the neurofilament-rich plexus in the cortical wall became
adult-likeduringthefirstpostnatalyearinhumans.Although
neurofilament-positive axons are found throughout the
developing auditory cortex, their origins (whether corticocortical or thalamocortical) are not known. To answer this
question,theinvestigatorsstudiedtheexpressionofvesicular
glutamate transporter (type 1 isoform, VGLUT1 and type
2 isoform, VGLUT2) in the auditory cortex of postmortem
humanbrainsatdifferentages.Earlierstudieshaveshownthat
VGLUT1 is expressed in the supragranular and infragranular
layersprimarilyincortico-corticalsynapseswhereasVGLUT2
isknowntopredominateinlayersIVandVIofthecortexand
actsasamarkerforthalamocorticalsynapses.Theinvestigators
foundthatmRNAforbothVGLUT1andVGLUT2waspresentin
thepresumptivehumanauditorycortexinthesecondtrimester
andduringthepostnatalperiod(1year-adulthood).Further,
supragranular and infragranular layers of the developing
auditory cortex were immunoreactive for VGLUT-1 whereas
LayerIVoftheauditorycortexwaslabeledwithVGLUT-2from
25GWonwards.
Immunohistochemical studies of involvement
of
proinflammatory
protein
S100A9
in
traumatic brain injury conditions. Investigators:
(Collaboration of HBTR) Dr. SK Shankar, Dr.
Anita Mahadevan, Prof. Ludmilla A MorozovaRoche, Professor in Medical Biophysics, Sweden
TheaimoftheprojectistostudyifproinflammatoryS100A9
proteinformsamyloiddepositsandserveastriggerforamyloid
cascade leading to neurodegeneration. The human brain
tissuesfromtraumaticbraininjuryarecurrentlyexaminedon
thepresenceofamyloidinclusionsofS100A9andotherrelated
inflammatory proteins by immunohistochemistry including
singleandsequentialstainingwitharangeofantibodiesapplied
in a sequence to the same tissue. The working hypothesis
is that the traumatic brain injury may serve as a precursor
stateandsignificantlyincreasestheriskofneurodegenerative
diseases such as Alzheimer’s and Parkinson’s. Therefore,
the immunohistochemical analysis together with in vitro
experimentsonS100A9willshedlightonthisissue.
17.
Diagnosis
of
Alzheimer’s
disease
using
fluorescent
probes. Investigators:
Dr.
T
Govindaraju, Assistant Professor, Bio-organic
Chemistry Laboratory, JNCASR, Bangalore, Dr.
Anita Mahadevan
Diagnosis of Alzheimer’s disease is possible only at late stage
based on behavioral tests or cognition in patients while
confirmative diagnosis is achieved only by post-mortem
examination of brain. Therefore, AB aggregates are attractive
target for developing diagnostic molecular probes to monitor
Annual Report
progressionoftheAlzheimer’sdiseaseaswellastoachievethe
early detection of AD. To address this issue the investigators
have come up with a fluorescent probe to detect amyloid
aggregatescausingAlzheimer’sdisease.Theinvestigatorshave
performed all in vitro studies showing binding affinity and
selectivity of the probe to amyloid aggregates. Further, the
probeoncerebralspinalfluid(CSF)samplesandbrainsample
ofAlzheimer’spatientwillbetestedtolocateamyloidplaques
inCSF,whichwillbeusefulinearlydetectionofADandalsoin
post-mortemexaminationofbrain.
18.
In vivo protein interaction network of
P.falciparum from severe cerebral malaria
patients. Investigators: (Collaboration of HBTR)
Dr. SK Shankar, Dr. Anita Mahadevan, Dr.
Namita Surolia, Molecular Biology and Genetics
Unit, Jawaharlal Nehru Centre for Advanced
Scientific Research, Bangalore
Sequestrationofparasitizederythrocytesinthemicrocirculation
of tissues is thought to be important in the pathogenesis of
severe falciparum malaria. A major variant surface antigen,
var/Plasmodiumfalciparumerythrocyte membraneprotein1,
expressedonthesurfaceoftheinfectederythrocyte,mediates
cytoadherence to vascular endothelium. To address the
question of tissue-specific accumulation of variant types, the
investigators propose to analyze ‘var’ gene transcription in
braintissueofpatientsdyingwithfalciparummalaria.
The investigators also plan to analyze ‘var’ gene transcription
fromlung,kidneyandspleenofpatientswhohavesymptomsof
‘multiorgandysfunctions’(MOD)andnotof‘cerebralmalaria’
per say. This analysis would provide the evidence of organspecificaccumulationofP.falciparumvarianttypessuggesting
thatparasitizederythrocytescanexhibitpreferentialbindingin
the body, supporting the hypothesis of cytoadherence-linked
pathogenesis.
19.
Identification of Cav 1.3 splice variants in
SNpc in Parkinson’s disease. Investigators:
(Collaboration of HBTR) Dr. SK Shankar,
Dr. Anita Mahadevan, Prof. Vijayalakshmi
Ravindranath, Centre for Neuroscience, Indian
Institute of Science, Bangalore
Parkinson’sdisease(PD)isamovementdisordercharacterized
byrestingtremors,bradykinesiaandrigiditycausedbydeathof
dopaminergicneuronsinsubstantianigraparscompacta(SNpc)
ofthebrain.ThereistheselectivedegenerationofSNpcneurons
2013-14
andtheirterminalsinstriatum.Amongtheseveralhypotheses
put forth to address cell death, mitochondrial dysfunction,
oxidative stress and accumulation of misfolded proteins in
the cytosol (Lewy body) have been studied extensively. More
recently it has been shown that SNpc neurons exhibit L-type
calcium channel, Cav1.3, assisted autonomous pace-making,
which could potentially result in increased cytosolic calcium
resulting in neurotoxicity. Thus, Cav1.3 channels could play
a role in the selective susceptibility of SNpc neurons in PD.
A short splice variant of Cav1.3, Cav1.3-42A has been shown
topromotecalciuminfluxintothecellincontrasttothelong
variantCav1.3.ThusthepresenceofgreateramountsofCav1.342A relative to Cav1.3 could lead to increased intracellular
calcium. The investigators measured the relative levels of
Cav1.3andtheshortsplicevariantCav1.3-42Ainmousebrain
regions.Concomitantly,levelsofCav1.3weresignificantlyless
in ventral midbrain. These results indicate that the presence
of Cav1.3-42A in significantly higher concentration in ventral
midbrain,couldcontributenotonlytoamplifiedpace-making
butalsoresultinincreasedcytosoliccalciumlevelsinneurons
thuscontributingtodegenerationoftheseneurons.
20. A retrospective study to evaluate genes expressed
in Notch Pathway, prognosis and treatment
response in gliomas (Provided Control brain
tissues only). Investigators: (Collaboration of
HBTR) Dr. SK Shankar, Dr. Anita Mahadevan,
Dr. Rajeswari Narayanappa, Department of
Biotechnology, DSCE, Bangalore
Theobserveddifferencesinclinicaloutcomesinpatientswith
histologicallyidenticaltumorsofsimilargradeandsizeislikely
to be depend on the sort of molecular differences mentioned
above. The identification of these differences at the time
of initial surgery will permit the individualized tailoring of
therapeuticapproaches.
Thisstudyisdesignedtoevaluatedifferentiallyexpressedgenes
ofNotchpathwayfromgliomapatientsamples.Retrospective
studywillbecarriedoutusingparaffinembeddedtissueblocks.
RNA will be extracted after de paraffinization and proteinase
K digestion using standard molecular biology techniques.
Integrity and quantity of RNA retrieved will be determined
by NanoDrop. l Jg of RNA from each sample will be reverse
transcribed to cDNA using High capacity cDNA reverse
transcriptionkit(AppliedBiosystems).
RNAlevelsofthecandidategeneschosenfromNotchpathway
willbeassessedbyquantitativereversetranscriptasePCR(RT-
Annual Report
2013-14
PCR)onaRealTimethermocycler.Quantitativereal-timePCR
will be performed using SYBR green PCR Core Reagents to
analyzetheamplificationstatusofNotchpathwayrelatedgenes
andthreeendogenouscontrolsintriplicate.cDNAmadefrom
RNA isolated from normal brain samples will be used at as a
controlforeachoftheexperiments.
21.
Molecular stratification of adult anaplastic (Who
Grade- III) lobar gliomas. Lt Col Dr. KS Rajmohan.
Guides: Dr. Vani Santosh, Dr. Paritosh Pandey
(Funding by DBT)
Theaimofthisstudyistomolecularlystratifyadultanaplastic
WHO Grade III lobar gliomas (anaplastic astrocytoma,
anaplastic oligodendroglioma and anaplastic mixed
oligoastrocytoma)withrespecttotheirexpressionofmolecular
markerssuchas1pand19qdeletion,EGFRamplification,p53
mutation. IDH-1 mutation. MGMT methylation, expression
of novel biomarkers, INA,GADD45a,YKL40, and to correlate
the molecular profiles with histological subtype of AG, thus
aimingtoreduceinter-observersubjectivityinhistopathology
reporting of adult anaplastic lobar gliomas. Global gene
expressionprofilingofAOtumorswillbecarriedoutinorder
to identify novel biomarkers of diagnostic and prognostic
significance. The study has so far yielded clinically relevant
resultsandisinprogress.
22. Paired
sample
analysis
of
glioblastoma
biomarkers – generating a predictive model
for expression at recurrence. Ms. Sharmistha
Naskar. Guide: Dr. Vani Santosh
In order to understand the molecular genetic changes that
occurfollowingrecurrenceandtheircontributiontoincreased
aggressiveness,theproteinexpressionofselectedbiomarkers;
i.e.;p53,EGFR,IGFBP3,IGFBP5wereevaluatedin30paired
samples of GBM and SOX2 protein expression was evaluated
in 17 paired samples of GBM that recurred. Interestingly, the
investigatorsnotedthatthep53expressionremainsunalteredin
thepairedGBMsamples,suggestinganabsenceofapreferential
clonalexpansionofp53positiveornegativepopulationfollowing
exposuretoradiochemotherapy.Importantly,thepresentstudy
demonstratedasignificantincreaseintheexpressionofEGFR
(p=0.001)andSOX2(p=0.003)intherecurrentsamplewhen
compared to the initial sample of GBM suggesting a possible
roleplayedbythesemoleculescontributingtoradioresistance,
chemoresistance, increased invasiveness and stemness of
the recurrent tumor. Thus, these may be viewed as potential
targetsinthemanagementofGBMrecurrence.Usinganovel
mathematicalapproach,theinvestigatorshavetriedtogenerate
amodeltoassesstheclonalexpansionofgliomastemcellsand
thelevelofbiomarkerexpressionatrecurrence.
23. Analysis of gene expression profiles in the
peritumoral regions of glioblastoma and
functional characterization of novel biomarkers.
Ms. Kruthika BS. Guide: Dr Vani Santosh
In the current study, the investigators intend to identify
genesthatarehighlyregulatedintheperipheryofthetumour
compared to the core using the available Microarray data
and validate selected genes at RNA and protein levels. Genes
thatvalidateatRNAlevel,proteinlevelandalsoexpressedin
gliomacelllinesalongwithastrongliteraturebackupwillbe
selected for functional characterisation in cell lines by overexpression and/or knockdown studies. The investigators are
alsointerestedinlookingattheinvolvementofselectedgenes
inChemo-sensitivityandRadio-resistance.
24. Effects of temozolomide and its combination with
lonidamine on proliferation, cytotoxicity, ultrastructure and radiation response of malignant
human glioma cells. Ms. Kalyani Kumari. Guides:
Dr. Vijay K Kalia, Dr. BK Chandrasekhar Sagar,
Dr. Jagath Lal G
Primary cells of high grade gliomas obtained from tumour
biopsies were cultured in EMEM + 20% FBS. Ultrastructural
studies(TEM)showedthattheuntreatedgliomacellsshowed
roundednucleuswithaprominentnucleolus,plasmamembrane
andlotsofmicrovillilikeprocesses.TMZ(10and20µM,4hrs)
treatedcellsshowednucleardamage(indentednuclei,nuclear
fragments and smooth plasma membrane. Exponentially
growingcellsasmonolayerwerefixedinMethanol-AceticAcid
andstainedwith0.002%AcridineOrange.Thesecellsshowed
variable frequencies and cells, and micro nucleation, even
without any cytotoxic treatments. The damage was increased
afterTMZandirradiation(1-2GyCo60γray)
25. The role of aquaporin antibodies in the diagnosis
and management of neuromyelitis optica and
other central demyelinating disorders. Dr.
Deepa N. Guides: Dr. P Satishchandra, Dr. Anita
Mahadevan, Dr. Rose Dawn (Funding by IAN)
Annual Report
2013-14
ALS(NALS-CSF).Quantitativeanalysisofexpressionofvarious
proteinsinresponsetoALS-CSFwasstudiedinAstrocytesby
immunocytochemistry.Thestudiesrevealedadown-regulation
oftrophicfactorsVEGFandGDNFinALS,whileinflammatory
markers like IL6, and TNF-α were found to be significantly
upregulated, suggesting the role of neuroinflammation in the
exacerbationofthedisease.
Future studies are directed towards the expression of BDNF,
and iNOS in astrocytes, as well as all the aforementioned
proteinsinmicroglia.
Aquaporin 4 antibodies positive tested in serum of a patient with neuromyelitis
optica (Immunfluorecence assay using transfected cell lines)
Neuromyelitis optica (NMO) an idiopathic, severe,
demyelinating disorder of the central nervous system
that preferentially affects the optic nerve and spinal
cord. It is being encountered more frequently from India
with a significant proportion being earlier diagnosed
as Asian variety of optico spinal MS. Discovery of AntiAquaporin 4 antibody serum as specific biomarker for for
diagnosis of NMO has been fortuitous. Rigorous studies
of the prevalence of Anti-Aquaporin 4 antibodies in NMO
and its utility in distinguishing NMO from other CNS
inflammatory demyelinating disorders (CIDD) are lacking
intheliterature.Thisstudyaimstoestablishtheprevalence
of Aquaporin 4 antibodies in patients of NMO and CIDD
and to study its utility in differentiating between these
two entities and its therapeutic implications. Phenotypic
characterization, imaging profile of diagnosed cases of
NMOisbeinganalysed.
Neurophysiology
1.
Glial responses in sporadic amyotrophic lateral
sclerosis. Investigators: Dr. TR Raju, Dr. Phalguni
Anand Alladi, Dr. Sathyaprabha TN, Dr. Nalini A,
Mr. Dinesh Dhull (JRF), (Funding by DBT)
Primary astrocyte were exposed to CSF from ALS patients
(ALS-CSF)andcomparedwiththeNormalcontrolsandNon-
Figure 1: Representative Confocal photomicrographs of cultures stained for the
IL-6 (Green) and TNF-α (Red). Note the upregulation of both the proteins in the
cultures exposed to ALS-CSF as compared to the Normal controls and NALS,
shown quantitatively in the graph(*p<0.5 NC v/s ALS, #p<0.5, NALS v/s ALS for
IL-6, and **p<0.01 NC v/s ALS, #p<0.01, v/s ALS for TNF-α)
Figure 2: Representative Confocal micrographs of cultures stained for the VEGF
(Green) and GDNF (Red). Note the down regulation of both the trophic factors
in the cultures exposed to ALS-CSF as compared to the Normal controls and
NALS-CSF, shown quantitavely in the graph(*p<0.01 NC v/s ALS for VEGF, and
*p<0.05 NC v/s ALS for GDNF)
Annual Report
2013-14
Mitochondrial Health in Sporadic ALS model
Histogram showing Mitochondrial viability in control, control CSF (NC) and ALS
groups. Note the significant reduction (21%) in mitochondrial viability in the
ALS group.
Reactive Oxygen species (ROS) in-vivo
Representative Confocal micrographs of cultures stained for the VEGF (Green)
and GDNF (Red). Note the down regulation of both the trophic factors in the
cultures exposed to ALS-CSF as compared to the Normal controls and NALS-CSF,
shown quantitavely in the graph(*p<0.01 NC v/s ALS for VEGF, and *p<0.05
NC v/s ALS for GDNF)
2.
Isolation and characterization of toxic factor(s)
present in the CSF of amyotrophic lateral sclerosis
patients. Investigators: Dr. TR Raju, Dr. Nalini A,
Dr. Sathyaprabha TN, Dr. Phalguni Anand Alladi,
Dr. MM Srinivas Bharath, Dr. Aparna Sharma
(PDF), (Funding by DBT)
The present study was designed to investigate mitochondrial
dysfunction in the sporadic model of ALS. The mitochondrial
damageinlumbarregionofspinalcordinanimalmodelofALS
wasevaluatedbyMTTassay,whichshowedsignificantreduction
followingALS-CSFinjection.Theoxidativestressassaystoevaluate
the reactive oxygen species levels showed an increase in ROS
(DCFDAassay).ThesestudiespointoutthatALS-CFSaffectedthe
mitochondria.Further,proteomicsofthemitochondrialproteins
fromthespinalcordsofALS-CSFinjectedanimalsrevealedupregulation and down-regulation of several key proteins, thereby
identifyingthepathwayswhichleadtomitochondrialdysfunction.
Histogram showing Reactive oxygen species in spinal cord tissue extract in
all the experimental groups. Note the significant increase in released reactive
oxygen species shows oxidative stress in the ALS group.
Total mitochondrial proteins detected were 965 in the
proteomics profile to study the alteration of mitochondrial
proteins(spinalcord)insporadicALSmodelofwhich11were
up-regulatedand60down-regulated.
Proteomics Profile to study the alteration of mitochondrial
proteins (spinal cord) in sporadic ALS model
Total Mitochondrial Proteins detected - 965
Up-regulated -11
Down-regulated-60
(Critically up-regulated and down-regulated proteins listed
below)
Annual Report
Up-regulated proteins
Gene Symbol Description (Rattus norvegicus)
ALS/NC ALS/C
Bnip3I
BCL2/adenovirus E1B 19 Kda
2.327
1.799
protein-interacting protein 3-like
mt-Co2
cytochrome c oxidase subunit
2.202
1.766
mt-ND2
NADH dehydrogenase subunit 2 2.106
1.732
(mitochondrion)
2013-14
Proteomics analysis revealed up-regulation of Chitotriosidase
(CHIT-1)inALS-CSFcomparedtoN-CSF.ThelevelofCHIT-1
wasfurtherevaluatedbyELISAinalargercohortofpatients’
CSF,whichshowed17foldincreaseintheCSFsofALSpatients.
CHIT-1didnothaveadirecteffectonviabilityofNSC-34cells
asshownbyMTTassay.
Down-regulated proteins
ALS/NC ALS/C
0.546
0.550
0.472
0.647
0.384
0.382
0.630
0.793
0.788
0.773
0.763
0.762
0.758
0.791
0.788
0.567
0.525
Histogram showing Reactive oxygen species in spinal cord tissue extract in all
the experimental groups. Note the significant increase in released reactive
oxygen species shows oxidative stress in the ALS group.
4.
A study on the profiles of neurotrophic factor in
the rat spinal motor neurons following exposure
to cerebrospinal fluid from patients with sporadic
Amyotrophic Lateral Sclerosis. Investigators: Dr.
TR Raju, Dr. Sathyaprabha TN, Dr. Nalini A, Mis.
Sumitha (SRF), (Funding by ICMR)
Isolation and characterization of toxic factor(s)
present in CSF of patients suffering from Amyotrophic
Lateral Sclerosis. Ms. Anu Mary Varghese. Guides:
Dr. TR Raju, Dr. MM Srinivas Bharath, Dr. Nalini A
(Funding by CSIR Senior Research Fellow)
Mean Fluorescence
intensity (0-255)
250
200
150
100
50
0
NA
NC
3.
ALS-CSF reduced viability of NSC-34 cells by 40% (** p< 001, ALS-CSF vs NC).
CHIT-1 did not have any effect on NSC-34 cells.
A
B
AL
S
0.582
SC
Description (Rattus
norvegicus)
cyb5b
cytochrome b5 type B
precursor
RGD 1304982 Quinone Oxidoreductase-like
protein 2
ND2
NADH dehydrogenase subunit 2
COX2
cytochrome c oxidase subunit II
Atp 5sl
ATP synthase subunit s-like
protein
LOC100910689 cytochrome c oxidase
assembly protein COX11,
Cox7b
cytochrome c oxidase subunit
7B, mitochondrial precursor
Uqcr11
Ubiquinol-cytochrome c
reductase, complex III subunit XI
Sdhd
succinate dehydrogenase
(ubiquinone) cytochrome b
small subunit, mitochondrial
Neu4
sialidase-4
LS
Gene Symbol
C
Confocal photomicrographs showing reduced expression of VEGF (approximately
16%) in the motor neurons and also in the extracellular matrix of the ventral
horn of the spinal cord of ALS- CSF injected rats compared to the normal control
(compare A with B; Also note the reduction depicted in the Histogram ‘C’).
*
$$
Mean Fluorescence
intensity (0-255)
60
#
40
20
A
CHIT-1 was up-regulated by 17 folds in ALS-CSF compared to N-CSF. Values are
expressed as Mean ± SEM. ***p<0.0001 ALS-CSF vs N-CSF. n = N-CSF:19, ALS-CSF:32
B
AL
S
LS
NA
SC
NC
0
C
Quantification of the immunoflourescence intensity showed increased
expression of MCP-1 compared to normal control (compare A with B; histogram
‘C’) (*p<0.05, v/s NC, $$p<0.01, v/s SC, #p<0.05, v/s NALS). One-way ANOVA
followed by Tukey’s post-hoc test.
Annual Report
2013-14
Thisstudyinvestigatedtheexpressionofneurotrophicfactors
in the spinal cord of rat model of sporadic Amyotrophic
lateral sclerosis, using quantitative Real Time PCR and
Immunohistochemistry.Asignificantdecreasewasobserved
in expression of BDNF, FGF2, IGF1 and VEGF in neonatal
rat spinal cords following exposure to ALS-CSF. Down
regulationofBDNFmRNAwasmaximum(6.8folds)andthe
expressionofBDNFreceptorTRK-Bwasalsodown-regulated
followingALS-CSFexposure.Theinflammatoryresponseviz.
increasedexpressionofMCP-1was notedfollowingALS-CSF
injection.Further,BDNFsupplementationhadasignificant
neuroprotectiveeffectontheNSC-34cellsexposedtoALSCSF.
5.
Effect of ALS-CSF on the expression of
neurofilament subunits in NSC-34 cells.
Investigators: Dr. TR Raju, Dr. Sathyaprabha
TN, Dr. Nalini A, Dr. Phalguni Anand Alladi, Dr.
Vijayalakshmi K (Funding by NIMHANS)
the neurofilament sub-units, NF-H and NF-Lin NSC-34 cells
upon exposure to ALS-CSF by immunocytochemistry and
Westernblottingwasexamined.Theinvestigatorsfoundstable
expressionofNF-HinNSC-34cellsuponexposuretoALS-CSF.
However,ALS-CSFinducedtheenhancedexpressionofNF-L
inthesecellscomparedtothecontrolgroupsviz.Cellsgrown
undernormalconditionsandthoseexposedtononALS-CSF.
A Nimmunoblot showing bands of phosphorylated and non-phosphorylated
epitopes of NF-H. Note, the 70kDa band of NF-L depicted an increase in cells
exposed to ALS-CSF (*p<0.05 vs. NC and #p<0.05 vs. NALS-CSF).
6.
Expression of NF-H&L in NSC-34 cells.
Representative Confocal micrographs of NSC-34 cells Immunolabeled for
neurofilament sub-units (NF-H, Green and NF-L, Red). Note that only NF-L (red)
shows increased intensity in cells exposed to ALS-CSF.
Aggregation of phosphorylated neurofilaments leading to
disruptionofaxonaltransportis apathologicalhallmarkofALS.
Toinvestigatethepossibilitythataggregationofphosphorylated
neurofilaments might have occurred due to the deranged
expression of the neurofilament subunits, the expression of
Neural correlates of well-being associated
with
mindfulness
meditation:
A
neuropsychophysiological and neuroimaging
study. Investigators: Dr. Bindu M Kutty, Dr. John
P John, Dr. Seema Mahrothra, Dr. Nirmala M
(SRF), Dr. Jyothi K (JRF) (Funding by DST-CSI)
EEG and ERP studies have been completed for 63 subjects;
the senior meditators with more than three years of daily
meditationexperience(n=23,meanage43yearsand0.3SEM),
thenovicemeditatorswith<2yearsofmeditationexperience
(n=19,meanage39yearsand0.7SEM)andcontrolgroup(n=
20, mean age 33 years and 0.5 SEM). There were significant
differencesinthepeakamplitudeandlatencyofP300studied
across groups. The senior meditators showed significantly
reducedlatencyforbothstandardandtargetstimulusfromthat
of controls and novice meditators. Novice meditators did not
showanysignificantdifferencebetweentheothertwogroups.
Representative P300 wave form recorded from CZ electrode location
Annual Report
Latency and amplitude of P300 from different electrode locations in Controls,
Novice and Senior meditators for target stimulus
2013-14
VSLratsshowedsignificantimpairmentinspatiallearningand
navigational abilities in Morris water maze task. Long-term
exposure (6 hours per day for 2 months) to CT significantly
enhanced the learning performances in Morris water maze
task in VSL (Ventral subicular lesion) rats. The rats showed
significant differences in their learning performances, both
rateoflearningandthetrendoflearninghavebeenenhanced
followingexposuretoCT.ThestudysupporttheabilityofCTin
establishingfunctionalrecoveryinVSLrats.
Latency and amplitude of P300 from different electrode locations in Controls,
Novice and Senior meditators for standard stimulus.
Figure R1: Represents the latency to reach the platform in Morris Water Maze
task using 60 days old rats . (A) During the acquisition from D1-D9; and (B) Ten
days after the last acquisition from Normal control (NC), Vehicle control (VC)
and Ventral SubicularLesioned (VSL) rats. Graph plots the Mean±SEM (n=12)
Note the decrease in escape latency during 9 days (D1-D9) of acquisition of the
task followed by retention (R) after 10days between the VSL and normal control
(*p <0.05vs NC); and VC (#p<0.05vs VC).and .*p<0.05 was considered as
statisticallysignificant.
Power spectral density plots of three different meditative states of an advanced
meditatorand a novice meditator.
7.
Efficacy of behavioral strategies of enriched
environment and physical exercise with dietary
supplements on establishing a sustained
functional recovery in ventral subicular lesioned
rats. Investigators: Dr. Bindu M Kutty, Dr. Laxmi
T Rao, Dr. Preethi Hegde (RA), Mr. Vijay Kumar
K (SRF) (Funding by DBT)
ThespatialnavigationalstudyusingMorriswatermazetaskwas
usedtoinvestigatetheefficacyofcombinationtreatment(CT)of
enrichedenvironment(EE)withphysicalexerciseanddietary
supplementation on behavioral and cognitive performances
inratswithCNSdegenerationandcognitiveimpairment.The
investigatorshavedevelopedtheratmodelwithhippocampal
degenerationandcognitiveimpairmentbyselectivelylesioning
the ventral subiculum bilaterally (VSL) using ibotenic acid.
Figure R2: Latency to reach the platform in Morris Water Maze task in the same
rats ( >90 days old ) when tested after 30 days of exposure to CT for VSL rats .
Rats from different groups were trained for 9 days . Graph plots the Mean±SEM
of latency of the rats to reach the platform from Normal Control (NC), Vehicle
Control (VC) and Ventral Subicularlesioned (VSL) rats. Note a significant increase
in the latency to reach the platform in the VSL rats in comparison with Normal
Control (***p<0.001) and Vehicle group (p###<0.001).
Additionally, Nose Poke Operant Task has been carried out
to assess the importance of attention and working memory
properties of cognition and to investigate whether ventral
subicular lesioning (VSL) affect these attributes of cognition.
Preliminarystudieshaveshownthatventralsubicularlesioning
produced considerable degree of attention and working
memory deficits and thus showed significant impairment in
Annual Report
2013-14
performing the five-hole nose poke operant task. Studies are
ongoing to evaluate whether exposure to CT would enhance
thecognitiveperformancesinfiveholenosepokeoperanttask.
The investigators have standardized the immunostaining for
immaturenewbornneuronsexpressingDoubleCortin(DCX).
Photomicrograph depicting the DAB stained immature newborn neurons
expressing Double Cortin (DCX) positive adult hippocampal progenitors within
the subgranular zone (SGZ) of the dentate gyrus
Mean percentage of correct responses in a two-choice serial reaction
time performance in an operant conditioning task. Both VSL(10 days) and
VSL(30 days) rats showed poor performance on day 8 when compared to NC
and VC group of rats.NC: Normal control, VC: Vehicle control, VSL (10 days):
Ventral subicularlesionedrats (10 days post surgery), VSL(30 days): Ventral
subicularlesioned rats (1 month post-surgery). Data is represented as Mean+SE,
P<0.0001
Acquisition performance in Nose poke to light stimuli in operant
conditioning paradigm on day 8 between groups. Here the comparisons
were made between groups showing poor performance in both VSL (10 days)
and VSL(30 days) group of rats even after 8 days of training. NC: Normal control,
VC: Vehicle control, VS (10 days)L: Ventral subicularlesioned rats (10 days post
surgery), VSL(30 days): Ventral subicularlesioned rats (1 month post surgery).
Data is represented as Mean+SE, p=<0.0001.
8.
Evaluation of EEG dynamics and sleep in long
term vs short term practitioners of vipassana
meditation. Investigators: Dr. Bindu M Kutty, Dr.
S. Sulekha, Dr. TR Raju (Funding by ICMR)
9.
Role of amygdala in the modulation of
hippocampal and prefrontal cortical functions in
stress: Implications for the treatment of affective
disorders. Investigators: Dr. BS Shankaranarayana
Rao, Dr. TR Raju (Funding by DBT)
Severe, traumatic stress or repeated exposure to stress
can result in long-term deleterious effects, including
cell atrophy and death, which in turn result in memory
impairments and behavioral abnormalities. The
hippocampus, amygdala and prefrontal cortex are
essential components of the neural circuitry mediating
stressresponses.Thehippocampusandmedialprefrontal
cortex,whichprovidesnegativefeedbackregulationofthe
stressresponse,areparticularlyvulnerabletodegenerative
changes caused by chronic stress. In contrast, amygdala
whichpositivelyregulateshypothalamo-pituitary-adrenal
axis undergoes hypertrophy after stress. Several studies
havedemonstratedthattheamygdalaiscriticallyinvolved
in mediating stress-induced affective behaviors and
modulating hippocampal function. Thus, the project was
focused to evaluate the role of amygdala in mediating/
modulating stress effects on hippocampal and prefrontal
corticalfunctions.Thiswasachievedbyeitherpermanently
or temporarily inactivating the basolateral amygdala
during stress. The results show that both permanent
inactivation of amygdala and the temporary inactivation
could prevent chronic stress induced dendritic atrophy
Annual Report
2013-14
and volumetric alterations in the hippocampus. Further,
itwasalsoobservedthattheamygdalainactivationcould
alsopreventstressinducedspatialmemoryanddecreased
hippocampal synaptic plasticity. The results show that
modulating amygdala can be a potential tool in treating
stressinducedcognitivedeficits.
Effect of 6h EE on depression-induced anhedonia (A) and behavioural despair
(B). Depressed rats exposed to 6h of EE show increased sucrose preference and
reduced immobility in the forced swim test indicating a reduction of depressive-like
behaviour. Data expressed as Mean ± SEM. One-way ANOVA Followed by Tukey’s
post hoc test, ***p < 0.001 vs. NC and ##p < 0.01, ###p<0.001 vs. DEP. NC =
Normal control (n = 10), DEP = Depression (n = 10), SA = Saline administered
(neonatal) (n = 12), DEP + 6h EE = Depressed rats exposed to 6h of EE for 14 days
(n = 12), 6h EE per se = Normal rats exposed to 6h of EE for 14 days (n = 10).
Prevention of stress-induced impaired long-term potentiation by inactivation of
basoloateral amygdala during stress. Stressed animals showed decreased longterm potentiation when compared with normal animals after high frequency
stimulation (HFS). However, BLA inactivation during stress prevented this
impairment. Representative fEPSP’s are shown in the inset. Data expressed as
Mean ± SEM. Normal control (n=13 slices), ST= Rats subjected to 10 days of
immobilisation of stress (n=14 slices), LI+ST= lidocaine inactivation + stress
(n=13 slices), VC (SAL) +ST= vehicle control (0.9% saline) + stress (n=14 slices)
and SC= sham control (n=12 slices).
Bar graphs depicting the magnitude of LTP before and after high frequency
stimulation. Stress-induced impaired hippocampal synaptic plasticity is blocked by
temporary inactivation of BLA during stress. fEPSP slope values from 0-20 minutes
was taken for the before HFS analysis and fEPSP slope between 20-80 minutes was
taken for after HFS analysis. Data expressed as Mean ± SEM. Normal control (n=13
slices), ST= Rats subjected to 10 days of immobilisation of stress (n=14 slices),
LI+ST= lidocaine inactivation + stress (n=13 slices), VC+ST= vehicle + stress
(n=14 slices) and SC= sham control (n=12 slices). One-way ANOVA followed by
Tukey’s post hoc test. ***p<0.001, vs. NC; $$$p<0.001 vs. ST.
10.
Cellular and molecular basis of endogenous
depression
induced
cognitive
deficits.
Investigators: Dr. BS Shankaranarayana Rao, Dr.
TR Raju (Funding by DBT)
Effect of EE on depression-induced learning deficits in the radial arm maze.
(A) Depressed rats exposed to 6h EE for 14 days show complete recovery of
spatial learning and memory. Depression-induced learning impairment in the
last block is completely reversed after EE exposure (B). Data expressed as Mean
± SEM. Two-way ANOVA followed by Bonferroni’s post hoc test, ***p<0.001
vs. NC; ##p<0.01, ###p<0.001 vs. DEP. NC = Normal control (n = 14), DEP
= Depression (n = 14), SA = Saline administered (neonatal) (n = 11), DEP + 6h
EE = Depressed rats exposed to 6h of EE for 14 days (n = 10), 6h EE per se =
Normal rats exposed to 6h of EE for 14 days (n = 10).
Depression is the most prevalent forms of chronic mental
illness.Currenttreatmentsfordepressionareinadequateand
progress in understanding the neurobiology of depression
is slow. Depression is known to cause several deficits
includingcognitiveimpairments.Severalclinicalstudieshave
demonstrated that chronic depression has many deleterious
effects on hippocampal,cortical and amygdalar structure and
functionthatleadstolearningandmemorydeficits.Although
there are structural and functional evidences from human
studiesindicatingcognitivedysfunctionindepression,noneof
thestudieshaveexaminedtheneuralbasisofcognitivedeficits
in depression. Studying cognitive deficits in animal models
often helps to discern the cellular and molecular pathologies
underlying the disease and develop suitable therapeutic
strategies.Accordingly,intheproposedstudytheinvestigators
are planning to evaluate the effects of newer antidepressants
escitalopram, reboxetine treatment and enriched enrichment
on depression-induced cognitive deficits comprehensively at
multiple level of neural organization namely, morphological,
biochemical, electrophysiological, molecular and behavioral
levels.Also,currentstudywillexploreeffectofantidepressant
treatmentandexposuretoenrichedenvironmentoncognitive
Annual Report
2013-14
functions in depressive condition. Neonatal clomipramine
exposureresultedinbehavioraldepressionandimpairedspatial
learning. Enriched environment ameliorated both behavioral
depressionandcognitivedeficitsindepressedrats.
The chronic temporal lobe epilepsy rat model has been
developed using the chemoconvulsant pilocarpine, and has
beenvalidatedbothelectrophysiologicallyandbehaviorally.
12.
11.
Evaluation of antiepileptic activity of medicinal
plants in animal models of epilepsy. Investigator:
Dr. BS Shankaranarayana Rao (Funding by DST)
Epilepsy is the third most common neurological disorder and
in many cases, even multi-drug therapy is not effective and
neurosurgical procedures may be indispensable. The current
therapeutictreatmentofepilepsywithmodernantiepilepticdrugs
(AEDs) is associated with side-effects, dose-related and chronic
toxicity,andteratogeniceffects.Drugsalsohavelowtherapeutic
window so it need continuous therapeutic drug monitoring and
approximately30%ofthepatientscontinuetohaveseizureswith
currentAEDstherapy.Further,alargenumberofdruginteractions
seen with almost all current antiepileptic drugs make it more
difficult to attain easy control on seizures. Traditional systems
ofmedicine have beenexploringnumberofmedicinalplantsas
an effective treatment of epilepsy over the past centuries but so
far have not got the place among the standard anticonvulsant
medication because their efficacy has not been established. The
idealanti-seizuredrugwouldsuppressallseizureswithoutcausing
majoradverseeffects.Thus,researchforfindingnewdrugswith
less adverse effects and more efficacy, seems to be essential.
Accordingly,thestudyfocusesontheevaluationofantiepileptic
potentialofmedicinalplantstofindoutthemechanismofaction
responsibleforitsantiepilepticactivityalongwithpossibleactive
constituents responsible for the same. Extractions of plants
Eclipta albaandPistacia integerrimawillbeusedforevaluation
of antiepileptic activity and also in combination with standard
antiepileptic therapy. Further evaluation of effect of particular
fraction of the extract for effects of synaptic plasticity in the
hippocampuswouldbestudied.
Temporal alteration in EEG power spectrum from the sensory motor cortex.
Baseline (A), SE (B), 24h post SE (C), 48h post SE (D), 5days post SE (E) and 10 days
post SE (F). X axis: Frequency bands: low Delta (0.5-2.5Hz), Delta (0.5-4Hz), Theta
(4-8Hz), Alpha1 (8-10Hz), Alpha2 (10-13Hz), Beta (13-30Hz), Gamma (30-45Hz),
Theta-Alpha (6-10Hz), Sigma (11-14Hz); Y axis: Absolute power (µV2). n=4.
Effect of celestrus paniculatus on cognitive
deficits in chronically stressed rats: A
behavioral, neurochemical, structural and
electrophysiological approach. Investigator: Dr.
BS Shankaranarayana Rao (Funding by DST)
Chronic stress impairs spatial learning in radial arm maze and chronic
Celastrus paniculatus treatment to stressed rats ameliorated learning
impairments. (A) Acquisition of the RAM task across trails (B) Show performance
in blocks 7 and 8. Data is represented as mean ± S.E.M. NC: normal control.
ST: rats subjected to restraint stress for 21 days (6h/day). ST+ VE, ST + CP-400
and ST + CP-600: stressed rats subjected to 14 days of treatment with vehicle,
Celastrus paniculatus 400 or 600 mg/kg, i.p., respectively. One-way ANOVA
followed by Tukey’s post-hoc test. ***p<0.001 Normal vs stress. $$p<0.01
stress vs stress + drug treatment.
Severe,traumaticstressorrepeatedexposuretostresscanresultin
long-termdeleteriouseffects,includinghippocampalcellatrophy
anddeath,whichinturnresultinmemoryimpairments.Chronic
stressisknowntoprecipitateseveralaffectivedisordersincluding
depression,posttraumaticdisorderandanxiety.Drugsofnatural
originareknowntopossesseffectsonthecentralnervoussystem
and are emerging as promising alternative therapies in the
treatment of psychiatric disorders. Accordingly, the aim of the
presentstudywastoevaluatetheeffectofCelastrus paniculatus
oil treatment on stress-induced spatial learning and memory
impairment, changes in acetylcholinesterase (AChE) activity and
synaptic plasticity in the hippocampus. Male Wistar rats were
subjectedtorestraintstressfor21days(6h/day).Stressedratswere
treatedwithCelastrus paniculatusoilfor14days.Theinvestigators
observed that chronic restraint stress impaired spatial learning
in partially baited radial arm maze.Interestingly, Celastrus
paniculatustreatmentamelioratedstress-inducedspatiallearning
impairmentinradialarmmazetask.Thus,thestudyindicatesthat
Celastrus paniculatusisapotentialnaturaldrugforthetreatment
ofstress-inducedspatiallearningimpairment.
13.
Cellular and molecular basis of epilepsyinduced cognitive deficits. Investigator: Dr. B.S.
Shankaranarayana Rao, Dr. Meghna Saxena
(Funding by DBT)
Annual Report
2013-14
modeled depressive-like phenotype in adult male Wistar rats
and validated depressive-like behaviour using the sucrose
preference and forced swimming tests. Depressive animals
demonstrated enhanced anxiotypic behaviour in the openfield test and reduced dendritic arborization was observed in
hippocampalCA1neuronsusingtheGolgi-coxtechnique.Itis
possiblethatthisstructuralalterationcontributestoimpaired
learning and poor synaptic plasticity. The aim of the study is
to use the knowledge from these experiments in developing
effectivestrategiestotreatdepressiveillnesses.
Epilepsy-induced reduction in the volumes of the hippocampus. Alterations
in hippocampal and dentate gyrus volumes following 24h, 40d and 54d
following status epilepticus. (a) left hippocampus, (b) right hippocampus, (c)
left dentate gyrus and (d) right dentate gyrus. **p≤0.0001 compared with
respective control group (student-t test).
About 1% of human population worldwide suffers from
epilepsy.Otherconditionsassociatedwithepilepticseizuresare
learning and memory impairments. Among different types of
epilepsy,temporallobeepilepsyisthemostcommononeandis
characterizedbyrecurrentseizures,whichisoftenrefractoryto
drugtherapy.Ithasbeenreportedthatenrichedenvironment
is shown to be helpful in treating animal model of stress,
Alzheimer’s,Parkinson’sandHuntington’sdisese.Inaddition,
enriched environment is shown to be effective in enhancing
hippocampal neuronal plasticity and improves hippocampal
dependent learning and memory functions in animal models.
Therefore,thecurrentstudyassessestheeffectofantiepileptic
drug and influence of enriched environment on cellular and
molecularchangesassociatedwithepilepsy-inducedcognitive
deficits.Theinvestigatorsareusingthreedifferentinterventions
for this study: (a) new generation antiepileptic drugs, (b)
enriched environment, (c) the combination of anti-epileptic
drugs and enriched environment. Lithium-pilocarpine model
wasusedtoinducetemporallobeepilepsyinWistarrats.Cellular
and molecular changes in terms of morphological alteration,
glial response, neuronal death, synaptic plasticity, calcium
binding proteins, proliferation, survival and differentiation of
neuronsfollowingepileptogenesisisbeingstudied.
14.
Cellular, molecular and electrophysiological
basis of depression-induced cognitive deficits.
Investigator: Dr. BS Shankaranarayana Rao, Dr.
Mahati Krishna, (Funding by CSIR)
Thecurrentprojectwasdesignedtounderstandthebiological
basis of major depressive disorder. The investigators
Depressive-like animals have fewer intersections on apical (left) and basal
dendrites (right) in CAi pyramidal neurons of the hippocampus. Sholl’s
analysis of pyramidal neurons showed that depressive like animals had lesser
dendritic arborization compared to normal animals. Data expressed as Mean
± SEM. repeated measures Two-way ANOVA followed by Bonferroni’s post-hoc
test **p≤0.01, ***p≤0.001 vs. NC.
15.
Maternal separation anxiety and fear learning/
memory: Effects on sleep architecture in adulthood.
Investigators: Dr. Laxmi T Rao, Dr. Bindu M Kutty,
Ms. Shravanthy (JRF), (Funding by CSIR )
The impact of early maternal separation and isolation stress
during stress hyporesponsive period (SHRP) on fear memory
retention and sleep in rats were studied. Since REM sleep is
important to integrate newer information with previously
stored emotional experiences, neuronal replay during REM
sleep was analyzed in a greater detail. Rats were subjected to
maternalseparationandisolationstressduringpostnataldays
5-7timesdailyforsixhoursforaperiodofthreedays.Thesleep
studyandfearmemoryretentiontestwerecarriedoutintwomonth-old rats. The neuronal replay during REM sleep was
analyzed using different parameters.The investigators found
that MS rats had showed increased time in sleep and REM
sleepperse.Thiswasassociatedwithincreased fearmemory
retentionandfeargeneralization.Thedetailedanalysisofthe
local field potentials during REM sleep across different time
period of REM sleep showed increased theta oscillations (612Hz)inthehippocampus,amygdalaandcorticalcircuits.The
increased fear generalization and increased REM sleep with
variationsinneuralreplayinMSratscouldbepossiblyrelated
tothepersistentactivityoftheHPAaxisduringtheSHRP.
Annual Report
2013-14
16.
A multimodal approach to evaluate the efficacy
of enriched environment in ameliorating early
maternal separation induced changes in brain
function: A morphological, biochemical and
behavioural study in rats. Investigators: Dr.
Laxmi T Rao, Dr. Bindhu OS, Jain University,
Bangalore (Funding CSIR and ICMR)
17.
Evaluation of age-related synaptic changes
in human substantia nigra pars compacta.
Investigator: Dr. Phalguni Anand Alladi, Dr. TR
Raju, Ms. Jyothi HJ (JRF), (Funding by ICMR)
The investigators have earlier found that the synaptic proteins
synaptophysinandsynaptotagminshowedonlyamildreductionwith
ageinthenigraofAsianIndianssuggestingfairextentofpreservation.
Synaptogamin being a calcium sensor, the investigators further
studied the expression of the glial calcium binding protein S100β
toevaluatetheroleofgliaincalciumsequestration.Densitometric
analysisperformedineachofthesubsectionsi.e.medial,intermediate
and ventrolateral regions of human nigra revealed that the glial
calcium binding protein did not show significant alterations in
expression with age, possibly suggesting absence of active calcium
overloadwithaginginthispopulation.
A representative photomicrograph showing S100b expression in the glia in
human substantia nigra pars compacta. The scatter plot shows stable expression
of the protein with age.
18.
dopaminergic (DA) neurons during development, adulthood
andagingcouldelucidatetheetiopathogenesisofPD.However,
suchstudiesinhumansarenotfeasible;thereforetwodistinct
micestrainsandtheirF1crossbredswereusedasexperimental
models to understand the phenomenon seen in these ethnic
populations. The differentiation and survival associated
proteinsarebeingstudiedinthem.
Confocal images of Tyrosine hydroxylase (TH) expression (A&B, Red) in the
substantia nigra of C57BL/6 mice. The neurons were labeled with TUNEL to
identify apoptotic cells (arrows, C) and Bax (D). On a Western blot (E) note the
higher expression of TH in the adult CD1 mice (which have more number of
dopaminergic neurons), compared to the C57Bl/6 mice.
19.
Glial responses in Sporadic Amyotrophic Lateral
Sclerosis: An in-vitro experimental study. Ms.
Pooja Shree Mishra. Guides: Dr. TR Raju, Dr.
Sathyaprabha TN, Dr. Nalini A (Funding by UGCCSIR Senior Research Fellowship)
Primary astrocyte and microglial cultures were exposed to
CSF from ALS patients (ALS-CSF) and compared with the
Normal controls and Non-ALS (NALS-CSF). Quantitative
analysisofexpressionofvariousproteinsinresponsetoALSCSF was studied in Astrocytes by immunocytochemistry.
Thestudiesrevealedanup-regulationofPGE2andCOX-2,
suggestingneuroinflammation.Themicroglialcellsshowed
morphological transformation from ramified to amoeboid,
increased proliferation, and enhanced Iba1 expression
suggesting neuroinflammatory activation in response to
ALS-CSF.
Evaluation of developmental apoptosis and nigral
neuronal response in two mice strains with
differential sensitivity to 1-methyl-4-phenyl-1,
2,3,6- tetrahydropyridine (MPTP) and their
crossbreds. Investigator: Dr. Phalguni Anand
Alladi, Dr. TR Raju, Mr. S Niranjan (JRF), (Funding
by Science and Engineering Research Board, DST)
SeveralepidemiologicalstudiessuggestthatParkinson’sdisease
(PD) is less prevalent in Indians compared to Caucasians. In
Anglo-Indians,anadmixedpopulationofEuropeanandAsianIndianorigins,itisfivetimeslessprevalentthanIndiansrather
thantheexpectedaveraging.Studiesinthesepopulations,on
Annual Report
Representative Confocal micrographs of cultures stained for the COX-2 (Green)
and PGE2 (Red). Note the upregulation of both the proteins in the cultures
exposed to ALS-CSF as compared to the Normal controls and NALS-CSF, shown
quantitatively in the graph(*p<0.5 NC v/s ALS, #p<0.5, NALS v/s ALS for COX2,
and *p<0.05 NC v/s ALS, #p<0.05, NALS v/s ALS for PGE2)
In this study, the expression of microRNA-206 (miR-206), a
key regulator in the muscle regeneration process was analysed.
QuantitativeRealTimePCRwasperformedtoassessthechanges
in the gastrocnemius and biceps brachii of ALS-CSF injected
neonatalrats.The3.7foldup-regulationinthegastrocnemiuscould
beacompensatorymechanismasitrepresentsthere-innervation
processfollowingdenervation.However,inthebicepsbrachii,miR206 showed a 2-fold down-regulation, indicating a difference in
theprogressionofthediseaseinthedifferentlimbs.Theseresults
highlighttheinvolvementofmusclesinthediseasepathology.
21.
Pathophysiology
of
Skeletal
muscle
in
Amyotrophic Lateral Sclerosis (ALS)- An
experimental study in a rat model. Ms. Shruthi S.
Dr. TR Raju, Dr. Gayathri N, Dr. Phalguni Anand
Alladi, Dr. Nalini A (Funding by CSIR)
Normal Control
Phase contrast images of the Microglial cultures. Note the transformation of
Microglia from the ramified (resting) to amoeboid (activated) morphology. Iba1 expression was also increased in ALS-CSF groups as compared to NC. The
graph shows the increased viability of microglia in ALS-CSF group as compared
to NC and NALS-CSF groups (**p<0.01 NC v/s ALS)
2013-14
ALS-CSF injected
Representative confocal images showing fragmented and extrajunctional NMJ
in ALS-CSF injected group as compared to normal.
20. Altered
expression
of
miR-206
in
the
gastrocnemius and biceps brachii of ALS-CSF
injected Wistar rats. Dr. R Sumitha. Guides: Dr.
T R Raju, Dr. Phalguni Anand Alladi, Dr. Nalini A
(Funding by NIMHANS and CSIR )
Effect of ALS-CSF on expression of microRNA-206 in rat gastrocnemius and
biceps brachii. The fold change is calculated following normalization to the
endogenous gene (SRP9) relative to the value of normal control. microRNA-206
expression was increased by 3.7 fold in the gastrocnemius and reduced by 2
fold in the biceps brachii of rats injected with ALS-CSF compared to the normal
control.
Normal Control
ALS-CSF injected
Representative confocal images of skeletal muscle stained for BDNF (green)
and IGF-1(red). Note the down regulation of both BDNF and IGF-1 in ALS-CSF
injected group as compared to normal control.
Annual Report
2013-14
The aim of the study was to investigate the changes induced by
AmyotrophicLateralSclerosis-CerebrospinalFluidintheskeletal
muscles of rat. The extensor digitorum longus muscle showed
distinctpathologicalchanges.Theα-bungaratoxinstainedNMJs
appearedpretzel-likeincontrolanimalswhereasthoseinALS-CSF
group were extrajunctional and fragmented into small clusters;
thusweredysmorphic.Theexpressionoftheneurotrophicfactors
namely,IGFandBDNFwasdown-regulated.
The cognitive function being assessed include a component of visual
‘gestaltperception’andauditory‘corollarydischargemechanism’.Sleep
studyhasbeencarriedoutin45schizophreniapatientsand27controls,
sofar.Ofthese,ERPstudywasdonein23schizophreniapatientsand7
controls.fMRIstudyhasbeeninitiatedin7schizophreniapatientsand8
controls.Thefollowingtabledepictssomeofthepreliminaryresultsfrom
sleepstageanalysisfromPolysomnographydataof15controlsand21
schizophreniapatients.Thepatientgroupclearlyhasashorterfirstsleep
cycleandoverallwakeupmoreoftenfromthemiddleofsleep,thanagematchedcontrolsubjects.
22. Neural correlates of well-being in long term
rajayoga practitioners - A multimodal study. Mr.
Ajay Kumar Nair. Guides: Dr. Bindu M Kutty, Dr.
John P John, Dr. Seema Mehrotra
Meditationandspiritualpracticesareknowntoenhancewell-being.
However, the underlying neural correlates and processes are not
well understood. The study uses Psychological assessments,EEG,
ERP and fMRI for correlating well-being in long term Rajayoga
practitioners(BrahmaKumaristradition).Analysisofsurveydata
from over 1000 Rajayoga practitioners, from across the country,
has been completed. High density EEG, ERP recordings and
Psychologicalassessmentdatafromover50Rajayogapractitioners
havebeenacquiredandfMRIacquisitionshavebegun.
Sleep stage distribution across first 3 sleep cycles in Healthy controls and
Schizophrenia patients
24. Behavioral validation of cognitive dysfunction in
a rat model of schizophrenia. Ms. Neethi Prem.
Guides: Dr. Bindu M Kutty, Dr. Laxmi T Rao, Dr.
John P John (Funding by NIMHANS)
N2PC (N2 Posterior Contralateral ERP) at PO7 shown for the “Who” intermediate
level of the ANGEL task: As expected, the contralateral waveform (blue, indicated
with a | mark that denotes latency and amplitude) shows a greater negative dip
compared to the ipsilateral presentation.
23. Examination of aberrant neural synchrony in
schizophrenia – A multi-modal EEG, fMRI and
polysomnography study. Mr. Arun. Guides: Prof.
Bindu M Kutty, Dr. John P John (Funding by
ICMR)
The study is an effort to find a correlation between EEG and fMRI
parameters of cognitive functions,and sleep EEG parameters in
schizophreniapatients,minimallyexposedtoanti-psychoticmedications.
The neurodevelopmental theory of schizophrenia (Murray &
S.W.Lewis,1987;Weinberger,1987,1995)postulatesthatthe
pathogenic conditions leading to schizophrenia occur in the
middlestageofintrauterinelife,longbeforetheformalonset
ofsymptoms.Anumberofmodelshavebeendevelopedbased
on this theory and one such model is the Neonatal Ventral
HippocampalLesion(NVHL)Modelwhichisthefocusofthe
currentstudy.
Thisstudyaimstoassessthecognitivedeficitsassociatedwith
neural circuitry between prefrontal cortex, hippocampus and
amygdala, the brain regions that are shown to be implicated
in schizophrenia. Changes in neural circuitry between these
regionswillbeassessedbyelectrophysiologicalstudies–single
unitactivityinmedialprefrontalcortexduringdecisionmaking
task.
Pathophysiologicalchangessuchascellularandmorphological
changes in prefrontal cortex, hippocampus and amygdala are
observedinpostmortemstudies.Thesestudieshavealsoshown
Annual Report
lossofGABAergicneuronsintheseregions.Thus,celldensity
andvolumetricanalysisoftheseregionswillbeundertakenin
NVHLratsandimmunohisotologicalassessmentofGABAergic
neurons using Glutamic Acid Decarboxylase 67 (GAD 67) as
markerisbeingperformed.
NeonatalVentralHippocampalLesion(NVHL)modelhasbeen
standardized and NVHL rats have been obtained. Behavioral
experimentssuchasopenfield,socialinteractionandpre-pulse
inhibitionareongoingusingNVHLrats.GAD67immunohistologicalstudieshavealsobeeninitiatedinexperimentalrats.
Representative images of Immunohistological staining of Glutamic Acid
Decarboxylase 67 (GAD67). Arrows show GAD 67 + neurons.
25. Role of enriched environment and antiepileptic
drugs on epilepsy-induced Cognitive deficits. Ms.
Vrinda M. Guides: Dr. BS Shankaranarayana
Rao, Dr. Bindu M Kutty (Funding by CSIR)
2013-14
Temporallobeepilepsy(TLE)isthemostcommonformoffocal
epilepsy and is often intractable. Cognitive impairments are
thehallmarkofTLE,butareoftenassociatedwithcomorbid
conditionslikeanxietyanddepression.Inthepresentstudy,
the investigators have used a rat model of chronic TLE to
assess the spatial learning and memory. Conventional Antiepileptic drugs (AEDs) reduce seizure frequency but not
the cognitive deficits and behavioral abnormalities. On the
other hand, newer AEDs are thought to be better in this
regard. Moreover, animal studies have shown promising
results with exposure to the Enriched Environment (EE) as
a therapeutic intervention in neurodegenerative disorders.
Accordingly,theroleofEE,newerAED(Levetiracetam)and
combination of EE and AED on epilepsy-induced cognitive
impairmentswereevaluated.Chronictemporallobeepilepsy
(TLE,Lithiumpilocarpine)modelwasdevelopedandepilepsy
was characterised electro-physiologically by studying EEG
and behavioral validation by Racine’s scale of epilepsy. In
the present study cognitive deficits were evaluated using
Morriswater maze(MWM),awell-established testtoassess
hippocampus-dependent spatial learning and memory in
rodents.Epilepticratsshowedimpairedspatiallearningand
memory compared to normal rats by displaying increased
latency to reach the hidden platform, spending less time in
thetargetquadrantandincreasedthigmotacticbehaviourin
theMWM.EEexposureshowedonlypartialrestoration,AED
(Levetiracetam)treatmentshowednearcompleterestoration,
whereascombinationofEEandAEDtreatmentshowedbest
restorationofcognitiveimpairment
Combination of EE and AED treatment showed best restoration of cognitive
impairment when assessed using Morris Water Maze (MWM) test.
26. Depression-induced cognitive deficits: Effect
of modulation of glutamatergic transmission
and brain stimulation reward. Ms. Suwarna
Chakraborty. Guides: Dr. BS Shankaranarayana
Rao, Dr. TR Raju (Funding by NIMHANS)
Annual Report
2013-14
Depressionischaracterizedbyanhedonia,decreaseinsynaptic
plasticity,enhancedanxiety,memorydeficitsandglutamatergic
imbalance leading to excitotoxicity in the brain. Strategies
thatcombatexcitotoxicityandenhancefunctioningofreward
pathwaysmaybebeneficialintreatingdepression.Thepresent
studywillexaminetheeffectofmodulationofbrainstimulation
reward and glutamatergic system at different levels of neural
organization to rescue endogenous depression-induced
cognitiveinrats.Itwasobservedthatdepressedanimalsshow
anhedonia and increased behavioral despair compared to
normalanimals.
Depressed animals show elevated immobility and anhedonia. A. Depressed animals
exhibit enhanced immobility indicating behavioural despair as compared to control.
B. Depressed animal were more anhedonic as compared to control. Data expressed
as Mean ± SEM. *p<0.05 **p<0.01 vs. Normal control, Student’s t- test.
27.
Role of Celastrus paniculatus on hypobaric hypoxia
induced oxidative stress and cognitive deficits in
Wistar rats. Mr. Vijaya Kumar K. Guide: Dr. BS
Shankaranarayana Rao (Funding by NIMHANS)
anxiolytic activity. However, it is not known whether CP can
produce its beneficial effects in hypobaric hypoxic condition.
Even though hypobaric hypoxia causes brain dysfunctions at
differentlevelsofneuralorganization,thetreatmentstrategies
areyettobeevolved.Accordingly,thepresentstudyisdesigned
to investigate the role of Celastrus paniculatus on hypobaric
hypoxiainducedcognitivedeficitsandassociatedbiochemical
alterations. The study demonstrates that exposure to seven
days of hypobaric hypoxia induced working memory deficits
and enhanced anxiety like behavior. Markers of oxidative
damageinvariousbrainregionswerealsostudiedanditwas
found that hypoxia exposure differentially impacts oxidative
status.ChronicCelastrus paniculatustreatmentcouldrestore
hypobarichypoxiainducedcognitivedeficitswithoutrestoring
oxidativestressindiscretebrainregions.
28. Role of amygdala in stress-induced cortical
plasticity. Mr. Sunil J Tripathi. Guides: Dr. BS
Shankaranarayana Rao, Dr. TR Raju (Funding by
DBT)
Chronicstresscausesdeleteriouseffectonlearningandmemory
and integrity of prefrontal cortex. The amygdala is critically
involved in mediating stress-related effects on behavior and
modulating frontal cortical function. The current study was
designed to investigate the role of temporary inactivation of
basolateralamygdala(BLA)onchronicimmobilizationstressinduceddeficitsinprefrontalcorticaldependentlearningand
memory.TheresultsshowedthatBLAinactivationsignificantly
prevented stress-induced deficits in novel object recognition
task.Theoutcomeofpresentstudyprovidesstrategiestotreat
stress-induceddeficitsbymodulatingBLA-mPFCcircuitry.
Restoration of hypobaric hypoxia induced enhanced anxiety.
Thereductioninbarometricpressureandtheconsequentfall
in the partial pressure of oxygen at higher altitudes lead to
hypobaric hypoxia (HBH). HBH caused alterations in mood,
psychomotorperformance,perceptiveprocessesandcognitive
deficits. However, the neurobiological mechanisms that
underlie these impairments are poorly understood and more
importantlycombatingHPHinducedbraindysfunctionsisnot
yetfullyestablished.Manystudieshaveusedsyntheticaswell
asherbalinterventionstocombathypobarichypoxia-induced
brain dysfunctions. Hypobaric hypoxia results in oxidative
stress,impairedlearningandmemoryandenhancedanxiety.On
theotherhand,CPpossessesantioxidantandneuroprotective
activities, improves learning and memory, and demonstrates
Temporary inactivation of BLA prevents the stress induced learning and memory
deficits in novel object recognition test.
29. Role
of
enriched
environment
and
antidepressants treatment on chronic stressinduced cognitive deficits. Ms. Shilpa BM. Guide:
Dr. BS Shankaranarayana Rao (Funding by CSIR)
Chronicstressresultsincognitivedeficitsincludinganxiogenesis
and depressive symptoms. The neural basis of amelioration of
Annual Report
these deficits is not completely understood. Accordingly, the
investigatorsevaluatedtheroleofantidepressantdrug,reboxetine
(SNRI-aselectivenoradrenergicreuptakeinhibitor)inalleviating
chronicstress-induceddepressionandcognitivedeficits.Thestudy
showed chronic immobilisation stress (CIS) induced behavioral
depression along with learning deficits and decreased dentate
gyrus(DG)andhippocampalvolume.CISanimalsdemonstrated
high anxiety and hypertrophy of basolateral amygdala (BLA)
volumes. Reboxetine, treatment ameliorated CIS-induced
behavioraldepression,spatiallearningandmemorydeficitsalong
withtherestorationofDGandhippocampalvolumes.
2013-14
Mr. Pradeep Kumar Mishra. Guides: Dr. Laxmi T
Rao, Dr. Bindu M Kutty (Funding by ICMR)
Single units (green, yellow, blue, red) were differentiated from the multiunit activity;
These units were recorded from infralimbic cortex (ILC) during extinction recall of
fear memory in NC and EMS rats.
Reboxetine treatment ameliorates stress-induced spatial learning and memory
impairments in partially baited radial arm maze task:
30. Combined role of dietery genistein and CIMT on
modulation of synaptic plasticity in intracortical
ischemic stroke. Ms. Sabitha K Rajesh. Guide: Dr.
Laxmi T Rao (Funding by ICMR)
Preclinical study provided evidence that diet enriched in soy
isoflavonesthatactasphytoestrogensisneuroprotectiveinstoke.
Constraint-InducedMovementTherapy(CIMT)isanintensive
neurorehabilitation therapy that aims to retrain the brain by
constraining the unaffected arm and forcing the use of the
weakenedarm.Asaresultofrepetitiveexerciseswiththeaffected
limb,thebraingrowsnewneuralpathways.Constraint-induced
movement therapy (CIMT) coupled with pharmacological
genestein treatment may be effective in modulating synaptic
plasticity and improve the recovery in stroke patients The
major objective of the study is to evaluate the combined effect
of genistein and constraint induced movement therapy in
ET-1 induced stroke model of ischemic brain damage using
morphological, immunohistochemical and electrophysiological
studies.
The intracortical Endothelin-1 model of ischemic stroke was
standardized.Morphologicalstudiestodeterminetheinfarctvolume
wasdonebyTTCstaining.Thegaitanalysisshowedabnormalityin
gaitpatterninischemicstrokegroupcomparedtocontrolrats.
31.
Impact of Early Life Stress on the Behavioral,
Electrophysiological and epigenetic factors in rats.
In the present study the electrophysiological studies were
undertaken to understand the neural mechanisms of mPFC
neuronsinvolvedinretentionandextinctionoffearmemory.
The study report is from two-month-old rats: normal control
ratsandratsexposedtoearlymaternalseparationandisolation
stress.Theratswereimplantedwithbundlesofwiresof25µm
diameterintheinfralimbiccortexofmedicalprefrontalcortex
(ILC). Seven-eight days after the surgical recovery, these rats
were subjected to fear conditioning and extinction trials. The
unitactivitywasrecordedinfreelymovingratduringdifferent
stages of the fear conditioning – acquisition, retention and
extinctiontrainingandextinctionrecall.
32. Prenatal valproic acid exposure in rats: The
neural mechanism of changes in attention. Ms.
Kumari Anshu. Guides: Dr. Laxmi T Rao, Dr.
Shoba Srinath (Funding by UGC)
The project aims to study attention in a prenatally induced
Valproic acid (VPA) rat model of autism by examining long-
rangeneuronalsynchronybetweenthemedialprefrontalcortex
(mPFC) and posterior parietal cortex (PPC). Additionally,
alteredexpressionofsynapticproteinssuchasGABAreceptors
andGephyrinwillbeevaluated.
The prenatal Valproate model of autism was standardized and
validated for autism like symptoms using different behavioural
tasks.Theanimalswereevaluatedforsocialcognitionin3-chamber
social interaction test, anxiety-like behavior using light-dark test,
Annual Report
2013-14
Maltesh Kambali. Guides: Dr. Laxmi T Rao, Dr.
Ravi Muddashetty (Funding by NIMHANS)
repetitivebehaviorusingmarbleburyingtestandstartleresponse
anditsinhibitioninprepulseinhibitiontest.
A
B
Prepulse Inhibition (PPI) under different prepulse intensity and interstimulus
intervals.
Time spent in the compartment with a new rat versus time spent in the compartment
with a familiar rat over 10 minutes in 3-Chamber social interaction test.
33. The role of Constraint Induced Movement
Therapy (CIMT) in cortical plasticity in animal
model of intracortical ischemic stroke. Ms. Nesin
Mathew. Guides: Dr. Laxmi T Rao, Dr. Anupam
Gupta (Funding by UGC)
Constraint Induced Movement Therapy (CIMT), a recent
physiotherapywhichinvolvestherestrainingofnon-impaired
arm and physiotherapy for the impaired arm, has shown
to improve the recovery in stroke patients. In this study, the
investigators try to understand the role of inter-hemispheric
crosstalkinrecoveryfromischemicstrokebyCIMT.Alsothey
willlookintoNMDAandAMPAreceptormodulationpreand
postapplicationofCIMT.
35. Ontogenesis of nigral dopaminergic neurons and
electrophysiological assessment of substantia
nigra of crossbreds of two mice strains with
differential
susceptibility
to
1-Methyl-4Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP).
Mr. Vidyadhara DJ. Guides: Dr. Phalguni Anand
Alladi, Dr. TR Raju (Funding by NIMHANS)
The investigators intend to unravel the mechanisms for
ethnicitybaseddifferencesinprevalenceofParkinson’sdisease
usinganimalmodels.Immunoperoxidasestainingfortyrosine
hydroxylase(TH)inthemidbraininadultsgroupiscompleted
(for C57BL6, CD1 & F1 of C57BL6 female X CD1 male).
Preliminarydatasuggeststhatthenigraldopaminergicneurons
oftheCD1strainarelargercomparedtoC57BL6.Further,the
neuronsofF1crossbredswereobservedtobelargerthanthat
oftheCD-1strains.Furtherassessmentofnumberofneurons
isbeingconducted.
The intracortical Endothelin-1 model of ischemic stroke was
standardized and validated with different motor performance
task and TTC staining. Rotarod data was taken for vehicle
control, sham control and ischemic stroke groups and the
ischemicstrokegrouphasshownadeclineintheperformance.
Thegaitanalysiswasalsoshowntheabnormalityingaitpattern
inischemicstrokegroup.
Low magnification photomicrograph showing immunoperoxidase staining of TH
+ve neurons in C57BL6 mouse midbrain section. SN = Substantia nigra, VTA =
Ventral Tegmental Area
A
B
Stride length of hind-limb and forelimb was calculated for normal control(n=3)
and ischemic stroke group(n=3). 4 walking cycle of each side of every rat was taken
into consideration.
Figure B: TTC staining confirms the infarct area white in colour.
34. Early maternal separation stress-induced anxiety
and its relation to anterior cingulate cortex
functions in processing of emotional tasks. Mr.
High Magnification representative photomicrograph showing
THimmunoreactiveneuronsinsubstantianigraparscompacta
of adult C57BL6, CD-1 and F1 crossbred of C57BL6 female X
CD-1male.Notethecellsofthecrossbreed(C57/Bl6XCD1)
arelargerthanthoseoftheparentstrain.
36. Assessment of developmental apoptosis and
mitochondrial responses in F1 crossbreds of
two mice strains with differential sensitivity to
1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydro-Pyridine.
Annual Report
Mr. H Yarriephang. Guides: Dr. Phalguni Anand
Alladi, Dr. TR Raju, Dr. BK Chandrasekhar Sagar
populationwerefoundtobeinHardy-Weinbergequilibrium.
TherewasnoassociationbetweenthegenevariantsandsSAH
or large and small aneurysms. Plasma NOx was significantly
associatedwithdevelopmentofvasospasm.PlasmaNOxlevels
were found to be significantly decreased patients with aSAH
whencomparedtocontrols.Furthermore,itwassignificantly
reduced in patients with angiographic cerebral vasospasm.
There was no significant association between the alleles and
plasmaNOxlevelsaswellasallelesandevidenceofvasospasm.
Furtherstudiesarebeingconductedtostudytheassociation
betweenaboveallelesandplasmatotalantioxidantstatuswith
developmentofvasospasm.
2.
Representative Laser Scanning Confocal images showing co-localization of Bax (A,
FITC, green), Bcl-2 (B, Cy3, red) and TH (C, Cy5, blue) in the substantia nigra of
adult C57BL6.
Thestudyinvolvesevaluationofdevelopmentalapoptosisofthe
dopaminergicneuronswithinthesubstantianigra,oftwomice
strainsi.e.C57/Bl6andCD1whiteandtheirF1crossbreds.Thisis
becausethetwostrainshavedifferencesintotalnigralneuronal
numbers at adulthood and are differentially susceptible to the
neurotoxinMPTP.Expressionofvariousproteinsassociatedwith
cell death and survival, like Bcl-2, Bax and Caspases are being
studied, during the ontogenesis of both the mice strains and
theircrossbreds,tounderstandthebalancesoftheseproteinsin
establishingthefinalnumberofneuronsatadulthood.
Neurosurgery
1.
Evaluation of the role of endothelial nitric oxide
synthase gene variants in the natural history
of
aneurysmal
subarachnoid
hemorrhage.
Investigators: Dr. Indira Devi B, Dr. Nagaraja D, Dr.
Rita Christopher (Funding by ICMR, New Delhi)
Theobjectivesofthisstudyweretodeterminewhethergenetic
variants of the endothelial nitric oxide synthase gene are
associated with increased risk for aneurysmal subarachnoid
hemorrhage (aSAH), elucidate whether the gene variants
alterthebioavailabilityofnitricoxide(NOx) inthevascular
system and lead to vasospasm and to identify whether the
genevariantsdistinguishgeneticallybetweensmallandlarge
ruptured aneurysms. A total of 250 aSAH patients and 250
healthyageandgender-matchedcontrolshavebeenrecruited
for the study and genotyped for eNOS4ab, 894G>T and
-786T>C.Allelefrequencydistributionsincontrolsandpatient
2013-14
Cortical
Plasticity
following
intercostals
musculocutaneous nerve transfer: A functional
magnetic
reasonance
imaging
study.
Investigators: Dr. Dhanjaya I Bhat, Dr. B Indira
Devi, Dr. HR Arvinda (Funding by DST)
Following neurotisation for brachialplexus injury,
reorganizationofthecorticalcentresoccurs.Thestudyaimsto
findoutthetimeoccurrenceofthereorganisation.
3.
Surgical trial in traumatic lntracerebral
haemorrhage. Investigators: Dr. S Sampath, Dr.
Jagath lal G, Dr. KVL Narasinga Rao, Dr. Dhaval
Shukla, Dr. Nupur Pruthi (Funding by NHS, New
Castle University)
4.
Chromosomal aberrations in a typical and
anaplastic meningiomas: prognostic implications.
Investigators: Dr. Dwarakanath Srinivas, Dr.
Vani Santosh, Dr. Sampath S (Funding by DBT)
Theobjectivesoftheprojectare:a)Tostudypatientoutcomeand
investigatefactorsthatpredictprogressionandrecurrenceofGrade
IIandIIImeningiomas.b)Tostudytheimmunohistochemical
expression of cell cycle proliferative markers (Ki 67 antigen,
Topoisomerase),angiogenesisandinvasionassociatedmarkers
(VEGF, tenacin and other ECM proteins), Tuomor suppressor
and oncogenic proteins (p53, EGFR), apoptosis regulation
proteins (Fas-APO1-CD95) and progesterone receptor protein
and correlate the dadt generated with tumor progression and
recurrence.c)Tostudytheestablishedchromosomalaberrations
suchasdeletionof22q,deletionofprotein4.1Bgeneon18p11,
codeletion of chromosomal regions 1p32 and 14q32 and other
relevant chromosomes by using the FISH (fluorescence in situ
hybridization)techniqueandchromosomespecificandcorrelate
theresultswithtumorprogressionandrecurrence.
Annual Report
2013-14
5.
Atypical and anaplastic meningiomas: prognostic
implications of clinicopathological features.
Investigators: Dr. Dwarakanath Srinivas, Dr.
Mohd. Abdul Majid, Dr. Vani Santosh (Funding
by NIMHANS)
6.
Development of virtual human brain and skull
model using Autodesk MAYA 2012. Investigators:
Dr. V. Vikas, Dr. S. Sampath (Funding by
NIMHANS)
Theprojectaimstodevelopavirtualatlasofthehumanbrain
using Autodesk Maya which is an internationally acclaimed
animation package. The atlas can be used for teaching across
variousdisciplines.Commercialpackageswhichareavailableat
presentareessentiallybasedonviewingplatformswhichlimits
theutilizationoftheatlastoapictographicatlas.Anindigenous
3-D atlas developed at NIMHANS would be customized into
a 3-D platform which would make the process of learning
neuroanatomy easier and also would form a platform for
furtheranatomicandsurgicalstudies.
7.
Glioma serum biomarker discovery through
proteomic
approaches.
Investigator:
Dr.
Arivazhagan A, Multi institutional Project
involving NIMHANS and IISc (Funding by DBT)
ThestudyhasidentifiednovelproteinsbyLCMS/MStechnique
whicharedifferentiallyexpressedinseraofGBMpatientswhen
comparedtocontrolsamples.Furtherfunctionalstudiesarein
the process to understand the biological significance of these
findings.
8.
Training in micro-vascular anastamoses on Rat
blood vessels (Central Animal Research Facility,
NIMHANS).Investigator: Dr. Nupur Pruthi.
9.
Image processing for improving diagnostic
accuracy in gliomas by Magnetic Resonance
Imaging (MRI) and histopathology. Investigators:
Dr. Suresh Nair N, Sri Chitra Tirunal
Institute for Medical Sciences & Technology,
Thiruvananthapuram, Dr. V Vikas (Funding by
Kerala State Council for Science, Technology and
Environment)
histopathology as yet are subjective with significant
interobservervariability.Imageprocessingtechniquesthough
significantly advanced in several fields have only recently
become standardized for medical images. Image processing
thus offers an avenue to objectively evaluate and extract
information from medical information be it MR sequences
or histopathologic images. The study has two arms, one of
which analyses the possibility of integrating information
across various MR sequences, another arm focuses on
extracting histopathologic features to classify the lesion into
variousgrades.Themethodologyaimstodevelopindigenous
paradigmsnotbasedoncommercialpackages.Thesepackages
aimtoindependentlysupplementinformationobtainedfrom
humanreadingofMRimagesandhistopathologicimages.
10.
Thestudydemonstratedthatdexmedetomidineinfusionduring
epilepsy surgery did not suppress the electrocorticographic
activity unlike many other anaesthetics. The spikes increased
during the dexmedetomidine infusion which persisted till 10
minutes after stopping the drug. The findings indicated that
spike rates during Dexmed infusion were higher compared
to preDEX (MAX CH B: p=0.007 and MAX CH A: p=0.079)
and PostDEX (MAX CH B: p=0.17,MAX CH A:p=0.79)
phases.Thespikerateincreasedin67.6%ofthepatientswhile
the others showed a decreasefrom preDEX to DEX phases.
The hemodynamic parameters were stable throughout the
procedure.Toconclude,Dexmedisusefulduringintraoperative
ECoG recording to enhance the epileptiform activity without
anymajoruntowardeffects.
11.
Gliomas are the most important primary CNS malignancies.
Accurate grading of gliomas has prognostic implications.
Accurate grading of gliomas preoperatively by Magnetic
Resonance Imaging (MRI) and postoperatively by
Effect of Dexmedetomidine on intra operative
electrocorticogram during surgery for medically
refractory
epilepsy.
Investigators:
Dr.A
Arivazhagan, Dr KR Madhusudan Reddy, Dr.
Sanjib Sinha (Funding by NIMHANS)
Effect
of
dexmedetomidine
on
electrocorticography in patients with medically
refractory
seizures.
Investigators:
Dr.
Arivazhagan, Dr. KR Madhusudan Reddy, Dr.
Sanjib Sinha (Funding by NIMHANS)
DexmeditomedinehasavariableeffectonEEGduringmesial
temporalsclerosispatientswhoundergosurgery.EEGshowed
decreaseinthespikesinmajorityofcases,andtherewasalso
anincreaseintheEEGspikesinsomecases.
12.
Expression of Cathepsin B, K, S and Elastin in
intracranial aneurysmal walls. Mr. Arun Babu.
Guides: Dr. Dwarakanath, Dr. Vani Santosh
Annual Report
This study is the first gene expression study of intracranial
aneurysm performed in the Indian population and we have
gotthefollowinguniqueresultswhichhavenotbeenevaluated
in the previous studies. Collagen1A2 and CTSB genes are
overexpressed and the TIMP4 gene is underexpressed in the
aneurysmal sac compared to the normal superficial temporal
artery taken from the same patient. In the present study, the
investigators have shown differential expression of COL1A2,
TIMP4andCTSBintheaneurysmalwallcomparedtonormal
artery similar to the previous studies published so far. They
have also shown the association or correlation of various
clinico-radiologicalfactorswiththeexpressionlevelwhichhas
notbeenreportedinthepreviousstudies.
13.
Molecular stratification of pediatric infratentorial
ependymoma – correlation with clinical
parameters. Dr. Nagarjun MN. Guides: Dr. S
Sampath, Dr. Vani Santosh, Dr. Jagath Lal G
Theaimsofthisstudyweretostratifypediatricinfratentorial
ependymomaswiththefollowingnovelmolecularbiomarkers
such as CBX7, LAMA-2, NELL-2, CDKN-2A, CHI3L1 and to
correlate molecular sub groups with disease progression and
overall outcome which could guide therapeutic strategies and
trendsinthetreatmentofependymoma.
14.
Proteome profile of medulloblastoma correlation
with histology, molecular subtypes and clinical
parameters. Dr. Vinayak Narayan. Guides: Dr. S
Sampath, Dr. Vani Santosh, Dr. Arivazhagan A
Identification of candidate biomarkers of diagnostic and
prognosticsignificanceinmedulloblastomathroughintegrated
Proteomic and phosphoproteomic profiling. The investigators
proposetostudytheproteomicandphosphoproteomicprofile
ofmedulloblastomathroughanintegratedapproach,inorder
toidentifynovelcandidatebiomarkers.Thesewillbeevaluated
fordiagnosticandprognosticimplicationsbycorrelatingwith
histology, molecular subtypes and clinical parameters, taking
two cohorts of patients. The study envisages a new approach
forthediscoveryofnovelbiomarkersofclinicalandprognostic
significance in medulloblastoma. The study is being done in
collaborationwithInstituteofBioinformatics,Bangalore,India.
Neurovirology
1.
Inflammation in Japanese encephalitis: Role of
IL2. Investigators: Dr. Tom Solomon, Dr. V Ravi,
Dr. Anita Desai (Funding by MRC, UK)
2.
2013-14
Immunopathogenesis of rabies: experimental
studies in mice. Investigators: Dr. SN Madhusudana,
Dr. Abhay Chowdhury (Funding by DBT)
Theimmuneresponsesthatoccurafternaturalinfectiontofixed
andstreetrabiesviruseswereinvestigatedintermsofcytokines
andchemokinesproduced,phenotypingofdifferentTcellsin
infectedmousebrainandantibodyresponseinperipheralblood.
Itwasfoundthatalltheimmuneparameterswereexaggerated
inmicewhosuccumbedtorabiesfollowingdelayedvaccination
incontrasttomicewhichwerenotvaccinated.Markedincrease
inCD4,CD8anddoublenegativecellswerefoundinthebrain
ofthesemice.Also,levelsofcytokinessuchasIFNgamma,IL
6 and IL4 and chemokines such as RANTES and IP-10 were
drastically elevated in mice which got delayed vaccination.
These observations show that immune responses play a dual
role in rabies encephalitis. They offer complete protection
against encephalitis if given soon after the exposure but may
exaggeratethediseaseprocessifgivenlateaftertheexposure
has occurred. The study is ongoing to further understand the
criticalroleplayedbyinnateandadaptiveimmuneresponses
inrabiesencephalitis.
3.
To investigate the antiviral property of an herbal
extract against rabies virus by in vitro and in vivo
studies. Investigators: Dr. SN Madhusudana, Dr.
Anita Desai (Funding by ICMR)
TheherbalextractformulatedbyDr.RajeshGhanjuwasprovided
by ICMR. The crude extract and its fractions were tested for
antiviral property against rabies virus (CVS) and street viruses
bothbyinvitrotestingbyinfectionofBHK21cellsandNeuro2
acellsaswellaschallengingexperimentsinSwissAlbinomice.
Though the original herbal extract and its fraction C13 and F4
had strong ability to inhibit viral replication for up to 8 hours
post- infection, they failed to protect mice with intramuscular,
intra-peritonealandoralroutesofinoculation.Itwasconcluded
thatthebioavailabilityoftheactiveingredientinmicemaynot
besufficienttoclearthevirusfromthebrainofmice.
4.
To study the neutralizing efficacy of 5 human rabies
monoclonal antibodies produced by Celltrion,
Korea. Investigators: Dr. SN Madhusudana, Dr.
Reeta Mani (Funding by Celltrion, Korea)
Passiveimmunizationisoneofthemostimportantparameter
of post-exposure prophylaxis. In recent times, several
multinational companies have developed human rabies
monoclonalantibodiesforpassiveimmunization.Fivehuman
Annual Report
2013-14
MabsprovidedbyCelltrion,SouthKorea,weretestedagainst
differentantigenicsitesofrabiesGproteintotesttheirefficacy
for neutralization of 6 different street viruses prevalent in
India.Theinvestigatorsarenowundertakinginvitrostudies
inNeuro2aCellline.Theinitialscreeningispromisingand
thestudyisinprogress.
5.
Th1 and Th2 Immune responses to different
schedules of rabies vaccination. Investigators:
Dr. SN Madhusudana, Dr. Manjunath
A systematic evaluation of Th1 and Th2 immune responses
to Intradermal and intramuscular rabies vaccination was
conducted in people who have taken pre and post exposure
rabies vaccination. The levels of interferon gamma (Th1) and
IL 4 (Th2) was determined by ELISPOT assay. It was found
that both types of vaccination induced strong Th1 and Th2
armsofimmuneresponseswhichlastsforoneyear.Therewas
significant elevation following a booster dose of vaccination.
Further, the levels of both IFN gamma and IL 4 significantly
correlated with levels of rabies virus neutralizing antibodies.
Further studies are ongoing to determine each response in
preventionofrabiesinhumans.
6.
Understanding the biology of Chikungunya virus
infection in permissive cell lines and mosquito
vectors. Investigators: Dr. Anita Desai, Dr. Brij
Kishor Tyagi, CRME-ICMR, Madurai, Dr. SN
Madhusudana (Funding by DBT)
Indirect immunofluorescence assay using a polyclonal
Chikungunya antibody confirmed successful infection in
cell lines C6/36 and C2C12. Identification of the cellular
components involves intermediate steps like growing cells
to extract cell membrane proteins, resolving the proteins on
a SDS-PAGE, Western Blotting and probing with antibodies
to detect a “band” corresponding to a protein(s) that bind to
CHIKV.Thesestepswerestandardisedtogivethebestresults
withoptimaluseofresources.Themoresensitivesilverstaining
method was utilized to detect the same. The excised protein
from the gel for C6/36, has been submitted to the Molecular
Biophysics Department, IISc Bangalore for MALDI-TOF to
characterise the protein, followed by MASCOT SEARCH to
identifyit.
Three mosquito species Aedes aegypti, Aedes albopictus and
Culex quinquefaciatus are being reared at CRME, Madurai.
Mosquito midguts from all the three species were dissected
andcollectedinordertopreparemosquitomidgutmembrane
proteins for SDS-PAGE and VOPBA experiments. Mosquito
midgutbrushbordermembranefraction(BBMF)proteinshave
beenisolatedandresolvedonaSDS-PAGE.
7.
Strengthening
surveillance
for
Japanese
encephalits in India. Investigators: Dr. V Ravi,
Dr. Anita Desai, Dr. Reeta Mani (Funding by
Centre for Disease Control, USA)
This project has the following objectives of (i) Evaluation
of the designated JE sentinel laboratories in India using a
standardized tool (ii) Identification of the gaps, if any, in
the effective functioning of the designated laboratories and
suggestionofmeasurestofillthegaps(iii)Conductingtraining
workshops for staff from the designated laboratories (State,
DistrictandNCDC)onstandardizedproceduresforlaboratory
diagnosis of JE (iv) Identification of laboratories within the
network which have capacity for testing other bacterial/viral
pathogens of AES and preparation of a training module for
providing hands on training for other bacterial pathogens (v)
Developmentandimplementationofaprotocoltoensurethe
quality of the laboratory network through an external quality
assurance program involving JE proficiency testing and cross
checking a proportion of positive and negative samples (vi)
Provision of onsite support to the laboratories whenever
problemsariseand(vii)InconsultationwithCDC,Indiaoffice,
arrangement of shipment of all samples of unknown etiology
to Center for Disease Control and Prevention, Fort Collins,
Atlanta, USA, for further testing. Work has been initiated on
identifying10laboratoriesinIndia.
8.
Immune signatures in Dengue virus infection.
Investigators: Dr. V Ravi, Dr. Anita Desai, in
collaboration with University of Yale (Funding by
Indo USA Vaccine Action Program Grant)
This is a collaborative investigation between Yale University
School of Medicine’s U19 and National Institute of Mental
Health and Neurosciences (NIMHANS) to examine immune
mechanisms prevailing in the Indian population against
Denguevirus(DENV).DENVhasbeenaseriouspublichealth
problem in India since the first widespread epidemic in
1996 and currently causes more than 10,000 cases per year.
The investigators propose to investigate individual immune
responses to DENV with a systems immunology focus and
taking advantage of recent technical advances in use in our
HIPCcores.FromDENVpatientsandasymptomaticDENVexposedsubjectstheywillquantifyfunctionalresponsesofall
majorarmsoftheimmunesystem(theinnatecells,Tcellsand
Annual Report
B cells), gene expression profiles in response to DENV, and
genetic determinants that have been implicated in defining
theoutcomeofresponsetoDENVinfection.Resultsofthese
investigations will be analyzed, integrated, and combined
withclinicalhistoryandresultsfromotherflaviviralimmune
responses to gain insights into the architecture of the
immunologicalresponsetoDENVandtoprovideinsightinto
hostimmuneandgeneticparametersthatdefinethecourseof
Denguepathogenesisinhumans.
9.
Immunological aspects of Chikungunya virus
infection with special reference to pathogenesis.
Mr. R Vijayalakshmi. Guides: Dr. Ravi
Vasanthapuram, Dr. Anita Desai
The study was undertaken to address some of the gaps that
existinthepathogenesisandimmunologyofCHIKVinfection.
Plasma viral loads of CHIKV and presence of CHIKV IgM
antibodieswerecorrelatedtohumancytokine/chemokinelevels
during acute CHIKV infection. Predominant inflammatory
responses were seen during acute phase mediated by IL-6,
IL-8, IP-10, MCP-1 and MIG. IL-6 and MCP-1emerged as
biomarkers of high viral loads. The occurrence of molecular
mimicrywasshownbetweenCHIKVE1andHLA-B27molecule
andVonWillibrandFactordomainofC3.Thephenomenonof
ADE in CHIKV infection in-vitro using P388D1 cell line was
demonstrated.
10.
A comparative study of innate and cell-mediated
immune responses in human immunodeficiency
virus infected individuals with and without
neurotuberculosis. Ms. Deepashri Rao. Guides:
Dr. Anita Desai, Dr. V Ravi, Dr. P Satish Chandra
Attheendof2012therewere35.3millionHIV-infectedpeople
aroundtheworldand1.6milliondeathsduetoAIDSin2012
alone. In individuals with neurologic disorders associated
withHIV/AIDS,TBofthecentralnervoussystemisthemost
common opportunistic neuroinfection. However, not all
individualswithtuberculosismanifestneurologicalsymptoms.
Understandingtheroleplayedbyhostimmunefactorsinsuch
individualsisnecessarytobetterunderstandthehostresponse
and address the issue of predisposition of certain individuals
to neurotuberculosis for more effective treatment strategies.
Innateandcellmediatedimmuneresponsesinsuchindividuals
arebeinginvestigatedinthisstudy.
11.
Study on molecular aspects of the pandemic
Influenza A 2009 (H1N1) virus with special
2013-14
reference to host immune factors. Investigators:
Ms. Maria Thomas. Guides: Dr. V Ravi, Dr. Anita
Desai
Influenza A 2009 (H1N1) is the first pandemic of the 21st
century. While the overall global case fatality rate of the
2009 pandemic H1N1 appears to be low, the fatality rate in
India was relatively higher. The host responses play a crucial
role in defense against influenza but in some instances they
may contribute to immunopathogenesis. Understanding the
pathogeniceventsleadingtoseverityisimportantfordesigning
better strategies for prevention and treatment. In this study,
themolecularaspectsofthevirusandthehostimmunological
factors that lead to the severity of the disease in comparison
withseasonalInfluenzavirusesarebeinginvestigated.
12.
mechanisms
involved
in
The
molecular
chikungunya virus – Host cell interaction. Mr.
Ayushman Ghosh. Guides: Dr. Anita Desai, Dr.
SN Madhusudana, Dr. N Gayathri
TheselectivetropismofCHIKVforboneandjointassociated
connectivetissuesandskeletalmusclescellsrequireagreater
understandingofthisinfection.Theidentity,distributionand
behaviourofcellularcomponents(virusspecificcellreceptors)
on permissive cells at the primary level would help delineate
a crucial step in virus-host interaction. The virus–receptor
interactionisamulti-stepprocessinitself;multipleattachment
receptors may be used sequentially or in a cell type specific
mannerandadditionallyco-receptorsmayalsobeinvolved.
The virus induces certain changes in the host cell replication
machinerytoaiditslifecyclewithinitshost.Thisstudyaimsto
illuminate fundamental aspects of these intricate phenomena
in order to acquire more information about them which have
notbeenreportedcomprehensivelyinliterature.
13.
Clinical and immunological profile of patients
with subacute sclerosing pan encephalitis. Dr.
Lt. Col. Nandita Hazra. Guides: Dr. V Ravi, Dr.
Sanjib Sinha, Dr. SN Madhusudana.
Subacute Sclerosing Panencepalitis (SSPE) is a devastating
“slow virus” brain disease which affects young children and
adultswhohadmeaslesabout5-15yearsearlier.
Although, SSPE has been reduced to sporadic cases due to
massimmunizationformeasles,thediseasestillholdsfirmin
countrieswheremeaslesimmunizationisinadequate.
Annual Report
2013-14
Thepreciseimmunologicalmechanismbehindthepathogenesis
of Subacute Sclerosing Panencepalitis (SSPE) is not clearly
understood.Despiteabriskhumoralimmuneresponse,thehost
isunabletoclearthevirus,whichpersistsasaresultofeither
host or viral factors. Although the involvement of cytokines/
chemokineshasbeenreported,theroleofTh1/Th2responses
hasnotbeeninvestigatedindetail.Thestudyofhostimmunity
mayprovideaclueabouttheroleofalteredhostimmunityin
determiningthepersistenceofmeaslesvirusinSSPEpatients.
This prospective case control study aims to research the
host cell mediated and humoral immunological responses in
patientsofSSPEandanalysethefindingswithrelationtoage
ofonset(childhoodonsetandadultonsetSSPE),clinicalstage,
progressionofillnessandradiologicalfindings.
Nursing
1.
Development and evaluation of the effectiveness
of integrated audio visual aided interactive
relapse prevention (IAVARP) intervention
among individuals with alcohol dependence
at peripheral and tertiary care. Investigators:
Dr. Prasanthi Nattala, Dr. Pratima Murthy, Dr.
Jayashree Ramakrishna, Ms. Sreevani Rentala
Amajorconcernwithteachingrelapsepreventionisthatalcohol
use triggers/high-risk situations operate in real life, and are
difficult to demonstrate within the confines of the treatment
center.Inthisproject,anintensiveIntegratedAudioVisualAided
InteractiveRelapsePrevention(IAVARP)interventionhasbeen
developed,withtheaimofhelpingpatientsandfamilymembers
tovisualizelifeafterdischargeinaveryrealmanner,andequip
themselves with various relapse prevention skills while still in
theprotectiveconfinesofthetreatmentsetting.
TheIAVARPmakesuseofliveactionvideosemployinghuman
characterstoportrayvariousrelapsepreventionstrategiesfor
individuals with alcohol dependence, which are designed to
simulate real life situations as much as possible. Some of the
relapse prevention components demonstrated include coping
skills, diversionary techniques, assertiveness skills, adaptive
communicationpatterns.
TheIAVARPispresentlybeingtestedatthetertiarylevel(Center
forAddictionMedicine,NIMHANS),andinaStateGovernment
setting (DIMHANS, Dharwad). Follow-up assessments are
scheduled during the first 6 months after discharge to assess
effectiveness of the IAVARP on three outcomes: quantityfrequency of alcohol consumption; number of drinking days;
meantimetakenforrelapse.
2.
GFATM Project – Strengthening institutional
capacity for nursing training on HIV/AIDS in
India. Investigator: Dr. Ramachandra (Funding
by GFATM)
The training project was planned under the them ‘A World free
of burden of AIDS, TB and Malaria’. During Phase II as well as
in Extended Phases II of GRATM project, 157 ANM’s/JHA’s in
6 sessions and 110 Nurses in 4 sessions from seven districts of
Karnataka(BangaloreRural,Tumkur,Chikkaballapur,Chitradurga,
Ramanagara, Manday and Bagalkote), have been trained. Two
refresher/retrainingsessionsoftwodaysdurationwerealsotaken
up for 55 nurses who had undergone training in HIV/AID’s in
PhaseIandtheearlystageofPhaseIIofGFATAMproject.About
65 nurses who had undergone training on HIV/AIDs previously,
were supervised for their skills and knowledge under supportive
supervisionprogrammebythetrainersinTumkurdistrict.
3.
Attitudinal factors influencing adherence and
non-adherence to antipsychotic medications in
patients with schizophrenia and BPAD. Ms. Ann
Deva Priya, J Guides: Dr. Ramachandra, Dr.
Suresh Bada Math
Ensuring adherence to prescribed treatment is a major
challenge in the management of almost all chronic medical
conditions.Conveniencesamplingwasusedforthestudy.The
MINImentalstatusexaminationandClinicalGlobalSeverity
Scale and Clinical Global Improvement Scale were used to
screenthepatientstoascertaintheirsuitabilitytoparticipate
in the study. Data were collected through a semi-structured
interview using socio-demographic and clinical profiles.
Morisk’s 8 item Medication Adherence Questionnaire was
used to assess medication adherence pattern. The rating of
MedicationInfluencesScalewasusedtoassesstheattitudinal
factors influencing the adherence and non adherence to
antipsychoticmedications.Theadherencepatternwasfound
to be better in patients with Schizophrenia than in patients
with BPAD. The attitudinal factors such as “perceived daily
benefit”, “fear of relapse”, “side effect relief with the current
medicationsand”“enablingthemtofulfilllifegoalswhenon
medications”,“deferencetoauthority”,“positiverelationwith
staff”stronglyinfluencedtheiradherence;whereasnotbeing
awareofillness,embarrassmentabouttakingmedicationsand
stigmaofillnessandmedicationsinfluencednonadherence.
There was a statistically significant association between
Annual Report
the duration of illness and adherence pattern in patients
with Schizophrenia (p = 0.029). Change in appearance with
medication also had significant association (p= 0.019) with
the adherence pattern in patients with Schizophrenia. The
attitudinal factors were largely perceived by both groups of
patientsinasimilarmanner.
4.
Dyadic perception of recovery from schizophrenia
at NIMHANS, Bangalore. Ms. Diksy Jose, Dr.
Sailaxmi Gandhi, Dr. Geetha Desai
Theaimofthestudywastoidentifytheperceptionofpatients
diagnosed with schizophrenia and their caregivers regarding
recovery from schizophrenia, to identify the convergence
and divergence in the perceptions and to formulate a theory
based on the findings. The main research questions were
aboutmeaningofrecovery,indicatorsofrecovery,andfactors
affectingrecoveryfromschizophrenia.
The study adopted a qualitative grounded theory approach.
Thedatawerecollectedfrom18patientsandcaregiversbased
ontheoreticalsamplingtechnique,fromNIMHANSOPD,IPD
and PRS settings. Semi-structured interview was conducted
to collect the data and the interviews were audio recorded
after obtaining informed consent from the participants. The
recordeddataweretranscribed,translatedandcoded.
Six main themes were emerged after the data analysis. The
themeswere,meaningofillness,meaningofrecovery,attributes
ofrecovery,indicatorsofrecoveryandfacilitatorsandbarriers
of recovery. There were convergence and divergence in the
perceptionofpatientandcaregivergroups;mainlydueto the
subjectiveandobjectiveinterpretationofsymptoms.Atheory
wasformulatedbasedonthefindings.
5.
Effectiveness of pranayama on depression, anxiety
and stress among residential elderly in selected
old age home at Bangalore. Mr. Kannan K. Guides:
Dr. Ramachandra, Dr. Naveen Kumar C
A pre-experimental study was conducted to evaluate the
effectivenessofpranayamaindecreasingthelevelofdepression,
anxiety and stress among residential elderly in a selected
old age home at Bangalore. The subjects were allotted to the
experimentalgroup(n=40)usingcomputergeneratedrandom
numbers.ThedatawerecollectedbyusingDepression,Anxiety
andStressScale(DASS-42).Thestructuredinterventionswere
carriedoutoveraperiodof90daysfor20minutesonadaily
basistotheexperimentalgroup.Theposttestwasconducted
2013-14
after 93 days. Data analysis revealed statistically significant
reductioninthemeanandstandarddeviationscoresonDASS
42.Overall,depression,anxietyandstressreducedsignificantly
among the residential elderly. Thus, the research hypotheses
were retained. Therefore, pranayama techniques are highly
effectiveinreducingthedepression,anxietyandstressamong
residentialelderly.
6.
Effectiveness of progressive muscle relaxation
programme on the occupational stress seen
among house keeping staff in NIMHANS. Ms.
Keerthini J. Guide: Dr. K Lalitha
This present study was designed with an aim to reduce
occupationalstressbyprogressivemusclerelaxationprogramme
on housekeeping staff on contract basis in NIMHANS. The
sample included sixty housekeeping staff working in various
psychiatric wards. A true experimental design was adopted
for the study. The study subjects were recruited into the
experimental and control group; pretest to assess the level
of occupational stress were administered to both the groups.
Progressive muscle relaxation programme consisting of 30
sessionswasadministeredbytheresearchertotheexperimental
group only. Analysis revealed statistically significant decrease
in the level of occupational stress in the experimental group.
The control group had statistically significant increase in the
levelofoccupationalstressintheabsenceoftheintervention.
The study indicated that the progressive muscle relaxation
programmewaseffectiveindecreasingthelevelofoccupational
stressamonghousekeepingstaff.
7.
Effectiveness of nursing intervention on social
and occupational functioning ability of patients
diagnosed with schizophrenia at NIMHANS. Ms.
Lija KL. Guide: Dr. Lalitha K
The study adopted the experimental, pre test and post test
design with control group with the aim to improve the social
and occupational functioning ability of patients diagnosed
with Schizophrenia. Using stratified random sampling, 30
femalesubjectswithschizophreniawereselectedfromfemale
psychiatricwardsofNIMHANS.Thedatawascollectedthrough
observationmethod,usingSocioDemographicDataSheetand
aRatingScalepreparedbytheresearcherandwithestablished
reliability and validity. The experimental group was exposed
to10sessionsofnursinginterventionforimprovingsocialand
occupationalfunctioningingroups.Thecontrolgroupreceived
10 sessions of health talk on various topics like interpersonal
relationship, communication and adherence to medication
Annual Report
2013-14
etc. The data was analysed using descriptive statistics,
Mann Whitney U test and paired T test. Results indicated a
significantimprovementinthelevelofsocialandoccupational
functioning ability in all dimensions. The finding showed
statistically significant difference between the experimental
groupandcontrolgroup.Thefindingsindicatedthattherewas
a significant difference between the scores obtained on social
and occupational functioning ability of patients diagnosed
with Schizophrenia, before and after the exposure to nursing
intervention.
8.
Assessment of knowledge regarding post
discharge care among caregivers of patients with
BPAD and Schizophrenia. Ms. Mrudula G. Guides:
Dr. Prasanthi Nattala, Dr. Santhosh Loganathan
Thedescriptivestudywasconductedinagovernmenttertiary
mental health centre. The aim was to assess the primary
caregiver’s knowledge regarding post discharge knowledge
about the care of patients diagnosed with schizophrenia and
bipolar affective disorder. Additional aim was to provide
themwithaninformationbooklet.Atotalof50subjectswere
recruited through convenience sampling; 25 had a diagnosis
ofschizophreniaand25werediagnosedwithbipolaraffective
disorder. A structured interview schedule was prepared and
wasusedtoassesstheprimarycaregiver’spostdischargecare
knowledge.Theresultsindicatedthatprimarycaregiversthey
hadmoderatelyadequateknowledgeaboutpost-dischargecare.
9.
Family emotional climate as perceived by outpatients with schizophrenia and their caregivers
at NIMHANS, Bangalore. Ms. Rajitha P. Guides:
Dr. Sailaxmi Gandhi, Dr. Jagadisha Tirthalli
ThestudyaimedtoexploreandcomparetheperceptionofFEC
as perceived by the patients and caregivers. The study was a
quantitative,non-experimentalcomparativestudy. Thetoolsfor
theassessmentofperceivedFECbythepatientsandcaregivers
were developed by the researcher; validity and reliability were
establishedbeforethemainstudy.Datacollectionwasdonein
the outpatient setting at NIMHANS, Bangalore. Analysis was
doneusingappropriatedescriptiveandinferentialstatistics.The
hypothesesofthepresentstudywere:(i)therewillbesignificant
difference in the perceived FEC by subjects of both groups (ii)
therewillbesignificantassociationofperceivedFECwiththeir
socio-demographic variables and (iii) there will be significant
association of the caregivers’ personality with the perception
of FEC by caregivers. The results suggested that there was no
significantdifferenceintheperceptionofvariousdomainsofFEC
bysubjectsofbothgroupsexceptwarmth.Thefirsthypothesis
wasnotaccepted.PerceptionofFECbypatientshadsignificant
association with their diagnosis. Caregivers’ perception of
FEC had significant association with their education. No other
socio-demographic and illness variables had association with
perceivedFECofbothgroups.Thesecondhypothesiswasalso
notaccepted.Caregivers’perceivedpositiveFEChadsignificant
positive correlation with extroversion and negative correlation
with neuroticism, similarly perceived negative FEC was found
to have significant positive correlation with extroversion,
psychoticismandneuroticism,andhencethirdhypothesiswas
accepted.Aninformationbookletonthemaintenanceofoptimal
familyemotionalclimatewasdevelopedbytheresearcherbased
ontheexpertopinionandsuggestions.Thiswasdistributedto
thestudysubjectsduringthefollow-upvisittohospital.
10.
The effectiveness of structured teaching
programme on knowledge regarding stress
management among caregivers of patients
diagnosed with schizophrenia, admitted to
selected psychiatric wards, NIMHANS. Ms. Alphy
Thomas. Guides: Dr. K Lalitha, Dr. Mahendra
Sharma, Dr. Geetha Desai
11.
Effectiveness of structured teaching programme
on the knowledge about human rights of mentally
ill among the primary caregivers of inpatients
with schizophrenia. Ms. Amrita Kuriakose.
Guides: Dr. Sailaxmi Gandhi, Dr. Naveen Kumar
12.
A pre-experimental study to assess the
effectiveness of structured teaching programme
on knowledge regarding the management of
violent behavior among caregivers of patients
diagnosed with schizophrenia at inpatient
facility, NIMHANS. Ms. Arpitha Elizabeth Jolly.
Guides: Dr. K Lalitha, Dr. Shivarama Varambally
13.
Job satisfaction of nursing personnel in an
organization. Mrs. Rebecca K. Guides: Dr.
Ramachandra, Dr. R Parthasarathy
14.
A study to assess knowledge and attitude towards
epilepsy among primary caregivers diagnosed
with epilepsy. Mrs. Lavanya D. Guide: Dr.
Prasanthi Nattala
15.
Comparative study to assess quality of life among
tobacco user and non-tobacco user adults in
NIMHANS Campus. Ms. Rituparna Samanta
Guides: Dr. Ramachandra, Dr. Vivek Benegal
Annual Report
16.
A comparative correlational study to assess
knowledge and attitude towards E-hospital among
nurses working in psychiatry and neurology wards
at NIMHANS, Bangalore. Mrs. Sheeba Sara Daniel.
Guides: Dr. Sailaxmi Gandhi, Dr. VL Sateesh
17.
A study to assess caregivers’ satisfaction of the
services at inpatient setting of the Department of
Child and Adolescent Psychiatry. Mrs. Usha SN.
Guides: Dr. Prasanthi Nattala
Psychiatry
1.
Parental consanguinity among schizophrenia
patients living in a rural community of south
India: A clinical and genetic investigation.
Investigators: Dr. Jagadisha Thirthalli, Dr. Rita
Christopher, Dr. Gangadhar BN, Dr. Naveen
Kumar C (Funding by DBT)
Thestudyaimsatevaluatingtheextentofparentalconsanguinity
amongpatientswithschizophrenialivinginaruralcommunity.
Thiswillbecomparedwithparentalconsanguinityofthegeneral
population in the same community. Parental consanguinity
will be assessed using both family history method and an
establishedgeneticmethod.160patientsand270controlshave
been recruited. Data collection is nearing completion and the
geneticdataistobeanalysed.Thisstudyhaspotentialtoyield
novelcluestothegeneticetiologyofschizophrenia.
2.
Neuroimmunogenetic and functional MRI
correlates of smooth pursuit eye movement
deficits: an imaging genomics study of a novel
composite
biomarker
for
schizophrenia.
Investigators: Dr. G Venkatasubramanian,
Dr. BN Gangadhar, Dr. V Ravi, Dr. Shivarama
Varambally (Funding by DBT)
Thisprojectaimstoexplorethepossibilityofanovelcomposite
biomarkerforschizophreniaphenotypeinvolvingnicotinergic
abnormalitiesandeyemovementabnormalitiesbyexamining
theirclinical,immunopathogeneticaswellasendophenotypical
correlates.Preliminaryobservationshaverevealedsignificantly
greater eye movement deficits in schizophrenia patients that
correlatewithDLPFCvolumedeficit.Ongoinganalysesattempt
toexaminetherelationshipbetweentheeyemovementdeficits
and immunological abnormalities in schizophrenia involving
plasma interleukin-6 levels/lymphocyte gene expression as
wellasothercytokines.
3.
2013-14
Augmentation of cognitive remediation in
schizophrenia
with
transcranial
magnetic
stimulation: A randomized controlled trial.
Investigator: Dr. Jagadisha Thirthalli, Dr. C
Naveen Kumar, Dr. BN Gangadhar, Dr. SK
Chaturvedi, Dr. Jitender Saini, Dr. A Sham
Sundar (Funding by DST)
ThisprojectwillexaminetheeffectofneuronavigatedTMSon
cognitiveretraininginpatientswithschizophrenia.Thisproject
hasjustbegun.Theinvestigatorsareintheprocessofacquiring
equipmentandrecruitmentofsubjectswillbedonesoon.
4.
Neuro-imaging endophenotypes in obsessive
compulsive disorder. Investigator: Dr. YC
Janardhan Reddy, Dr. Venkatasubramanian,
Dr. Chandrajit Prasad, Dr. Naren P Rao, Dr. Biju
Vishwanath (Funding by DBT)
Endophenotype validity for neuroimaging biomarkers is yet
to be established comprehensively in OCD. The study aimed
to establish this with the examination of treatment-naïve
patients and concurrent assessment of unaffected siblings
in comparison with matched healthy controls. This research
project has completed evaluation of 35 treatment-naïve OCD
patients and their unaffected siblings in 22 patients and 35
healthycontrols.
Obsessive Compulsive Disorder (OCD) is characterized by
cognitive deficits involving response inhibition and error
monitoring. These abnormalities have been demonstrated
convincingly in the neurocognitive models of OCD. In this
interim analysis, the investigators sought to examine this
cognitive deficit using an fMRI Go/No-go task in medicationnaïve, comorbidity free subjects with OCD in comparison to
healthycontrols.Theyhypothesizedthattheregionsinvolving
the fronto-striatal circuit viz. orbitofrontal cortex (OFC),
dorsolateral prefrontal cortex (DLPFC), anterior cingulate
cortex (ACC), caudate and putamen would show differential
activationsinpatientswithOCDcomparedtohealthycontrols.
Thirty-right-handedsubjectswithDSM-IV-OCDand25healthy
controls were examined during E-Sys delivered Go/No-Go
performance in 3-Tesla MRI. fMRI analysis [Go and No-Go
events]wasdoneusingSPM8[SmallVolumeCorrected(SVC)
FWE (Family Wise Error) <0.05 for the individual masks]
usingageasacovariate.Duringresponseinhibitioncondition
(No-Go), patients with OCD demonstrated significantly
deficient activation in the left ACC (BA-24), left DLPFC (BA9), and left caudate regions in comparison to HC whereas
Annual Report
2013-14
in the Go condition, left putamen had deficient activation in
patients in comparison to HC. Response inhibition is one of
the characteristic cognitive impairments seen in OCD. Study
observations suggest “fronto-cortical-striatal” network model
for response inhibition in OCD. Significant hypoactivation in
patientscomparedtohealthycontrolsduringtheGoandNo-Go
tasksdepicttheinvolvementofthesestructuresasmarkersthat
moderatethiscriticalcognitivefunctionandthuscouldunderlie
thepathogenesisofOCD.
5.
Real-world functioning in patients with
schizophrenia in a rural South Indian setting.
Investigator: Dr. Naveen Kumar C
This study was conducted in a rural community cohort of
schizophrenia patients. Groningen Social Disability Schedule
(GSDS) was used to assess social functioning of 156 patients
from this cohort. GSDS assesses functioning of individuals
across8roles,includingpersonalcare,family,kinship,partner,
parent, citizen, social and occupational. Mean GSDS score of
0indicatesnodisabilityandthescores1-3indicateincreasing
severityofthedisability.ThosewithmeanGSDSscoreof1or
less(indicatingmildornodisability)werecategorisedas‘notdisabled’andtherestas‘disabled’.Patientstakingmedications
for > 75% of the time since recruitment were categorized as
‘adherent’andtherestas‘poorly-adherent’.
Mean age was 42.5 years; the average duration of education
was 6 years. Mean duration of illness was 166 months. Mean
totalbaselinePANSSscorewas71.8.Afteranaverageofeight
years of follow-up, the mean GSDS score was 1.1. Among the
adherent patients, 43/115 (37.4%) were disabled. In contrast,
29/41(70.7%) of the poorly-adherent patients were disabled
(Chi-square=13.5;p<0.01;Oddsratio=4.0;95%CI=1.9–8.8).
Asadherencetomedicationsaloneisassociatedwithfairlylow
levelofdisabilityinthereal-worldfunctioningofschizophrenia
patients in rural communities, ensuring adherence should be
the priority of mental health professionals working towards
rehabilitation.
6.
Prospective study of metabolic abnormalities in
schizophrenia patients living in a rural South
Indian Community. Investigators: Dr. Naveen
Kumar C, Dr. Gangadhar BN, Dr. Jagadisha
Thirthalli, Dr. Rita Christopher, Dr. Kishore
Kumar KVC (Funding by NIMHANS)
The study was conducted in rural community at Turuvekere.
The study aimed to assess the cross-sectional prevalence of
metabolic abnormalities and compare this among randomly
selectedcontrolsubjectsresidinginthesamecommunity.Italso
aimedtoexaminethechangeinthesemetabolicabnormalities
inpatientsoversixmonthsoffollowup.
Atotalof169patientsparticipatedinthestudyand108ofthem
were followed-up for a period of 6 months of antipsychotic
treatment. The results indicated that 36% had not received
any treatment before their entry into this study. Risperidone
wasthemostcommonlyusedantipsychoticwithameandose
of 5.68 mg/day. Central obesity (CO) was significantly more
in women in both patients (64.8%) and controls (40%). The
prevalence of diabetes was 8.7% and 9.1% in patients and
controlsrespectively.After6monthsoftreatment,prevalence
of MS was not 35.2% which was not significantly different
from the baseline prevalence of 28.7%, nor was it different
from general population where it was 27.8%. Non-significant
increase in central obesity from 38% to 44% and metabolic
syndromefrom28.7%to35.2%werealsonoted.Itiscommonto
experienceincreaseinmetabolicabnormalitiesafter6months
of antipsychotic medication among schizophrenic patients.
However,therewerenosignificantdifferencesinprevalencein
comparisonwithhealthycontrols.
7.
Development of a partner focused intervention
for alcohol dependence and assessment of impact
on couples’ outcome. Investigator: Dr. Pratima
Murthy (Funding by ICMR)
Inthefirstphase,needsassessmentandfocusgroupdiscussions
werecarriedout.Theneedsassessmentwascarriedoutamong
50 women partners of men with alcohol dependence. The
interventionwasdevelopedandtestedin58womenpartners.
Thewomenshowedsignificantpre-postimprovementsonlife
satisfaction, self-esteem, symptoms of emotional distress and
perceivedsocialsupportfollowingtheintervention.
8.
Development of manuals to address risk factors
for non-communicable diseases. Investigator:
Dr. Pratima Murthy (Funding by WHO)
Aspartoftheproject,trainingmanualstoaddressriskfactorsfor
non-communicable diseases, with a focus on tobacco, alcohol,
diet,exercise,stressandweightmanagementaretobedeveloped
forcounsellors,communityworkersanddoctors.Ameetingof
expertstodiscussthesalientcomponentswasheldatNIMHANS
inFebruary.Thedevelopmentofthemanualsareinprogress.
9.
A naturalistic study of clinical and sociodemographic
characteristics
of
patients
Annual Report
attending psychiatric rehabilitation services for
rehabilitation. Investigators: Dr. Sivakumar T,
Dr. Chaturvedi SK, Dr. Thirthalli J, Dr. Nirmala
BP, Dr. Bhola P, Dr. Desai G, Dr. Gandhi S, Dr.
Kumar CN, Dr. Waghmare A, Dr. Udgiri S
Assessment of factors affecting psychiatric rehabilitation
is necessary to plan services and fame policies conducive
to recovery of persons with psychiatric disorders. There is
a paucity of studies examining factors affecting psychiatric
rehabilitation in the Indian setup. NIMHANS runs a unique
psychiatricrehabilitationservicesforpatientswithpsychiatric
disorders. The investigators would study the clinical and
socio-demographic profile of patients attending psychiatric
rehabilitation services and factors influencing rehabilitation.
The study would help in the process of understanding
rehabilitationneedsinpersonswithpsychiatricdisordersand
factorsinfluencingrehabilitationinthesetup.Theservicescan
be tuned to address felt needs and barriers interfering with
successful rehabilitation. The experience can help in making
policies and programs which can be used across the country.
This will help in reintegration of patients with psychiatric
disabilitywithmainstreamsociety.
10.
International Prevalence and Treatment of
Diabetes and Depression (INTERPRET-DD)
study. Investigators: Dr. SK Chaturvedi, Dr. S
Srikanta, Dr. Harish T, Dr. Manoj Sharma, Dr.
Ameer Hamza
Theproject,basedin16countries,looksattheprevalenceand
incidence of depression in adult onset diabetes mellitus. The
pilot phase is over and the data collection for final phase is
ongoing.Patientshavingdiabetesmellitusarebeingincluded
fromtheSamatvamDiabetesCentre,Bangalore.
11.
Effectiveness of a youth friendly mental health
Intervention to reduce and prevent common
mental disorders and enhance resilience among
at risk young women in an urban slum – the
MOGGU (Mental Health of Girls Growing Up)
study. Investigators: Dr. Prabha S Chandra, Dr.
Geetha Desai, Dr. Thennarasu, Dr. Girish N Rao
(Funding by Department of Health Research)
Thestudyrevealedthatthereispoormentalhealthliteracyamong
youngwomenfromlowincomesituations: Correctlabellingof
thedisorderwaslow-4.5%foranxietyand8%fordepression.
Though suicidality was labelled correctly by the majority of
2013-14
participants(63%),theywerenotabletoidentifytheseverityof
thesituationinthevignetteasoneneedingurgentintervention.
Majorityoftheparticipantsreportedtheywouldseekhelpfroma
friendorparent.Mentalhealthprofessionalswereconsideredby
onlyfewaspossiblesourcesofhelp(by9.7%oftheparticipants
foranxiety,22%fordepressionand2.6%forselfharm).Stigma
andlackofawarenesswerethefrequentlycitedreasonsfornot
seekingprofessionalhelp.
Thestudyalsoresultedinthedevelopmentofatool-Checklist
for Assessment of Gender Disadvantage (CAGED). This 15item tool which assesses four different domains of gender
disadvantagewasfoundtohavegoodinternalconsistencyand
adequatetestretestreliability.
The study also assessed the feasibility and acceptability of
Mobile health interventions among young women from low
incomegroupsintheformoftextmessages.
12.
Preventing and treating HIV co-morbidities
in India: Multi-tiered strategy for women.
Investigators: Dr. Prabha S Chandra, Dr. Veena A
Satyanarayana (Funding by ICMR)
13.
Clinical, cognitive and neuroimaging correlates
of apolipoprotien E (APOE) genotype in elderly
with late onset depression: A prospective study.
Investigators: Dr. PT Sivakumar, Dr. Sanjeev
Jain, Dr. Thennarasu, Dr. Venkatasubramanian
G, Dr. Jitendra Saini (Funding by ICMR)
Depressioninelderlywithonsetabove50yearsage(lateonset)
is associated with reduced hippocampal volume. APOE4 allele
and depression are considered as important risk factors for
dementia. Thisstudy evaluates the effect of APOE 4 allele and
Late onset depression on cognitive function and hippocampal
volume.Genotyping,baselineMRIscan,Clinicalandcognitive
assessment of 33 subjects with late onset depression has been
completed. Follow-up assessment of cognitive function and
measurementofhippocampalvolumewillbedoneafteroneyear.
14.
Alcohol: Harms to others-India. Investigators: Dr.
Vivek Benegal, Dr. Girish N (Funding by WHO)
15.
Double blind-randomized control study of the
efficacy of baclofen in the long-term treatment
of alcohol dependence. Investigator: Dr. Vivek
Benegal (Funding by Sun Pharmacological
Advanced Research Centre)
Annual Report
16.
2013-14
Cortical inhibition in unipolar and bipolar depression
compared to healthy subjects: A TMS-EEG study.
Investigators: Dr. Muralidharan K, Dr. Lakshmi
Yatam, Canada (Funding by CIHR through UBC)
Depressive episodes can occur in both unipolar major
depression and bipolar disorder. Unipolar major depression
(UD)hasbeendemonstratedtobesignificantlydifferentfrom
bipolar depression (BD) in symptomatology, course, family
historyofbipolardisordersaswellasresponsetoantidepressant
treatment and ECT. There is an urgent need to identify
biomarkers to differentiate UD from BD. This can prevent a
misdiagnosisofUDinatleast60%ofpatientspresentingwith
a depressive episode for treatment, with a potential risk of
manicswitch.Thecurrentstudyattemptstoinvestigatecortical
inhibitionasrecordedbyEMGandEEGusingTMSaspotential
bio-markers to cross-sectionally distinguish unipolar from
bipolardepression.
17.
Childhood
abuse
and
self-harm
among
women presenting with psychiatric disorders.
Investigators: Dr. Kavitha V Jangam, Dr.
Muralidharan K, Dr. N Janardhanan, Dr. K
Thennarasu (Funding by NIMHANS)
A large body of empirical evidence has documented high
prevalenceanddevastatingpsychologicaleffectsofphysicaland
sexualabuseofwomen.Onlyrecently,however,haveresearchers
investigatedviolentvictimizationofseriouslymentallyill(SMI)
women.However,thereisabsolutelynoliteraturewithrespect
to prevalence of childhood abuse among women with major
psychiatricdisordersinIndia.Also,thereisinadequateresearch
in the area of childhood abuse and its adult manifestations in
Indiathoughithastherapeuticimplications.Withthisreference,
the present research study aims to study the prevalence of
childhoodabuseamongwomenwhoareadmittedforpsychiatric
problemsinthepsychiatricfacility.Theresearchstudyalsoaims
at studying the prevalence of self harm among this population
and analyze the relationship between childhood abuse, self
harmandpsychiatricdisordersintheadulthood.Thestudydata
collectionwillbedoneinanin-patientfacilitywherewomenwith
severementalillnesshavebeenadmittedforthetreatment.The
studywillbedoneintwophasestostudytheprevalenceofthe
childhood abuse among women with psychiatric illness. In the
first phase, data collection will be done in the period of three
months to get the estimation of sample required for the main
datacollection.Basedonthethispilotdatacollection,thesample
sizeforthemainprevalencestudywillbedecidedwhichwould
beasecondphaseofthestudy.
18.
Persistent delusional disorder: A retrospective
chart review. Investigators: Dr. Muralidharan K,
Dr. Rashmi A
Delusional disorder or Persistent Delusional Disorder (PDD)
is a psychiatric illness characterized by stable and persistent
delusions which are relatively encapsulated and leaves much
of the personality intact, with a resultant high-functionality.
Research on PDD is limited and poor operational criteria
havemadeitdifficulttodistinguishitfromotheroverlapping
psychiatric disorders like schizophrenia and psychotic
depression. In addition, the diagnosis of PDD itself is often
complicated by the fact that patients with PDD rarely seek
psychiatrichelp.
Despite the long history of PDD as a psychiatric diagnosis,
relatively little is known about the demographic and clinical
profileofpatients,thefrequenciesofitssubtypesortreatment
response and outcomes. Further, the literature from India on
these aspects is limited. Given the paucity of literature on this
important yet under-researched psychiatric condition, a chart
review of patients who have been treated for PDD is planned.
Thisincludesthesocio-demographicandclinicalcharacteristics
ofpatients,co-morbidities,familyhistory,treatmentandfollowup.
19.
Effect of yoga on heart rate variability and cortical
inhibition in anxiety disorder and major depressive
disorder: An open trial. Investigators: Dr. BN
Gangadhar, Dr. S Varambally, Dr. Muralidharan K
Thisstudyattemptstoinvestigatetheimpactofyogaonheart
rate variability and TMS measures of cortical inhibition in
patientswithanxietydisordersandmajordepression.
20. Functional MRI: A diagnostic tool for amnestic
minimal cognitive impairment and early
Alzheimer’s dementia. Investigators: Dr. Srikala
Bharath, Dr. John P John, Dr. Keshav Kumar, Dr.
Jitender Saini (Funding by DST)
Afterstandardization,thedatacollectionstartedinSep2012.
42clientswithMildAlzheimer’sDementia,33clientswithMCI
and21matchedcontrolshavebeenrecruitedintheprojectwith
informed consent. All have undergone detailed clinical and
neuropsychologicalevaluationandfMRI.
21.
Neural and immunological predictors of SSRI
response in obsessive compulsive disorder:
Annual Report
Search for a composite biomarker. Investigators:
Dr. Janardhanan CN, Dr. YC Janardhan Reddy,
Dr. G Venkatasubramanian (Funding by DST)
This project aims to unravel a composite neuroimaging and
neuroimmunebasedbiomarkerforSSRIresponseinOCD.The
pilotphaseforthisprojecthasbeencompletedinthefirstyear
andthedatacollectionisongoing.
22.
Endocannabinoid-glutamate interactions in obsessive
compulsive
disorder:
cognitive
translational
implications. Investigators: Dr. Janardhanan CN, Dr.
YC Janardhan Reddy, Dr. G Venkatasubramanian
(Funding by DBT)
23. Eye tracking abnormalities in obsessive
compulsive disorder: A comparison with bipolar
disorder and healthy controls. Dr. Janardhanan
CN, Dr. G Venkatasubramanian
24. Neurobiological
correlates
of
symptom
modulation using transcranial direct current
stimulation in schizophrenia. Investigators: Dr.
G Venkatasubramanian, Dr. Janardhanan CN
25. White matter alterations in obsessive compulsive
disorders and its relationship with symptom
dimensions: A diffusion tensor imaging study.
Investigators: Dr. YC Janardhan Reddy, Dr.
G Venkatasubramanian, Dr. Janardhanan CN
(Funding by DST)
Previous diffusion tensor imaging (DTI) studies in patients
with obsessive-compulsive disorder (OCD) have reported
abnormalities of fractional anisotropy (FA). However
these results have been inconsistent. Confounding effect of
medicationscouldbeanimportantreasonforthisinconsistency
as pharmacological treatment could modify the structure of
cellmembranesand myelinsheaths.Asapreliminaryanalysis
underthisproject,whitematterintegrityabnormalitiesindrug
naïveOCDpatientswerecomparedwiththoseamonghealthy
controls.17drug-naïveOCDpatientsand18unrelatedhealthy
volunteers from the general population participated in the
study.Imageswereacquiredusing64directionsDTIsequence
in a 3T MRI scanner and analysed using Tract-Based Spatial
Statistics (TBSS) pipeline. Compared to controls, the patients
had lower fractional anisotropy (FA) values in left anterior
capsule (anterior limb, posterior limb and retrolenticular),
left external capsule and left superior corona radiata. There
2013-14
was no region in which patients had increased FA compared
tocontrols.Subsequentanalysesexaminingthewhitematter
correlates of treatment response examining patients that are
classified as SRI responders (N=15), SRI non-responders
(N=18) and healthy controls (N=33) revealed increased
fractional anisotropy in SRI responders as compared to both
non-responders and healthy controls with peak clusters
localisedtorightsuperiorlongitudinalfasciculus.Resultsofthe
study provide further evidence that widespread white matter
abnormalities are present in OCD patients. Presence of these
abnormalities in drug naïve status indicates the possibility of
theirroleinpathogenesisofOCDaswellasinSRItreatment
response.
26. Empowering adolescents with life skills – A
school based approach for promotion of health
and psychosocial competence – Preparatory
Phase. Investigators: Dr. Srikala Bharath, Dr.
Kishore Kumar, Dr. Seema Mehrothra, Dr. John
Vijayasagar (Funding by Navajbai Ratan Tata
Trust – small grant scheme)
Thepreparatoryphasefocusedonre-assessingtheneedsand
concernsoftheadolescents,familiesandschoolsbysixfocus
groupdiscussions.Reviewofthemanualsandtrainingmodel
for Life Skills Educators by the investigators were done. The
Manualswererevisedandprinted–PsychosocialCompetence
withLifeSkillsinAdolescents–LifeSkillsEducators’Activity
Manual Level I, II, III. A training CD was also prepared. A
LifeSkillsFacilitators’Manualwaspreparedandprinted.The
education department has been approached and permission
soughtforimplementingtheprogramin25governmentrural
schoolscontinuouslyoverthreeyearsinacomparativemanner.
InstitutionalEthicalClearancehasbeenobtained.
27.
A study of telomere length in dementias.
Investigators: Dr. Srikala Bharath, Dr. Sanjeev
Jain, Dr. Meera Purushotham (Funding by ICMR)
28. Augmentation
effect
of
low
frequencyrepetitive transcranial magnetic stimulation
over supplementary motor area in obsessive
compulsive disorder: a randomized controlled
trial. Investigators: Dr. Shyam Sundar A, Dr.
YC Janardhan Reddy, Dr. Jagadisha Thirthalli
Around40-60%ofpatientswithOCDdonotrespondadequately
to first-line treatment. Repetitive transcranial magnetic
Annual Report
2013-14
stimulation (rTMS) is a relatively safe and non-invasive
brain stimulation technique, found to be effective in many
neuropsychiatric conditions. In this study, the investigators
willevaluatetheefficacyofrTMSasanaugmentationstrategy
in OCD for people who have poorly/partially responded to
standard treatment. It is a placebo controlled trial with a
projectedsamplesizeof70.Thirtypatientshavebeenrecruited
tilldatewithnoreportsofanyseriouscomplications.
29. Effect of repetitive transcranial magnetic
stimulation on motor cortical excitability of
patients with obsessive compulsive disorder.
Investigators: Dr. Shyam Sundar A, Dr. YC
Janardhan Reddy, Dr. Jagadisha Thirthalli
This is an add-on project to the NIMHANS-funded project
“Augmentationeffectoflowfrequency-repetitivetranscranial
magnetic stimulation over supplementary motor area in
obsessive compulsive disorder: a randomized controlled
trial”. In the current study, the investigators plan to assess
the motor cortical excitability of the consenting subjects
from the former trial, both before and after completion of
thecourseofrTMS.Thecorticalexcitabilityparametersthat
willbestudiedincludeshortintervalintracorticalinhibition,
intracorticalfacilitationandcorticalsilentperiod,whichwill
bemeasuredusingTMS.Corticalexcitabilityhasbeenfound
tobealteredinpeoplewithOCDcomparedwhentohealthy
controlsandhasbeenlinkedtothepathophysiologyofOCD.
ThestudyaimstoexaminewhetherrTMShasaneffecton
corticalexcitabilityinOCDpatientsandhowthiscorrelates
with improvement in symptoms. Twenty four patients
have been recruited in this project till date with no serious
complications/adverseeffects.
30. A long term naturalistic follow-up study of
obsessive compulsive disorder (OCD) patients
with good and poor insight. Investigators: Shyam
Sundar, Dr. YC Janardhan Reddy, Dr. Suresh Bada
Math, Dr. Janardhanan C, Dr. Narayanaswamy,
Dr. Malvika Ravi, Dr. Arun Gadad
Naturalistic follow-up studies have shown that the long term
course and outcome of OCD is highly variable. Insight is one
of the factors that have been shown to be associated with
outcome of OCD. Very few studies have assessed insight in a
systematicmannerandassesseditscorrelationwithlong-term
outcome.Hencethecurrentstudyhasbeenplannedtoassess
theoutcomeofgoodandpoorinsightOCDoverlong-termina
catch-uplongitudinalstudy.
AllconsecutivepoorinsightOCDpatientswhohaveregistered
intheOCDclinicofNIMHANSfrom2004to2012willbetraced
alongwithanequalnumberofgoodinsightpatientswhowillbe
randomlyselectedfromtheOCDclinicdatabase.Thesepatients
havetheirbaselineassessmentswithstandardizedinstruments
used in the OCD clinic. Their follow-up assessment will be
conductedinthecurrentstudyusingstandardizedinstruments
to assess their current symptomatic status, insight level and
functioning status. This will help in comparing the long-term
courseofgoodandpoorinsightOCD.Sevenpatientshavebeen
assessedinthisprojecttilldate.
31.
An
Imaging
Genomics
Study
of
the
Neurometabolic & Neuroimmunological Effects
of Interleukin-6 in Schizophrenia. Investigators:
Dr. Venkat Subramanian, Dr. BN Gangadhar, Dr.
V. Ravi (Funding by DBT)
The background research project established support for
interleukin-6abnormalitiesinantipsychotic-naïveschizophrenia
andameliorationoftheseabnormalitieswithtreatment.Plasma
profile of various cytokines (antipsychotic-naïve schizophrenia
patients versus healthy controls) - Interleukins [IL] -2, 4, 6,
10,17AandTumornecrosisfactor[TNF],Interferon-γ[IFN-γ]
were assessed using commercial “cytometric bead array” kit
(BD Biosciences, San Jose, USA) as recommended by the
manufacturer. Plasma IL-6 levels were significantly higher
whereas IL-17 and IFN-γ levels were significantly lower in
schizophreniapatientscomparedtohealthysubjects.Theeffect
sizesweresmalltomoderatewithestimatesasfollowsIL-6:η2=
5.6%,Cohen’sd=0.48;IL-17:η2=3.7%,Cohen’sd=0.39and
IFN-γ:η2=3.2%,Cohen’sd=0.36.
32. Structural and functional connectivity of
hippocampus in schizophrenia: Evaluation of
neuroimmunological and neurotrophic factors
interactions using diffusion tensor imaging and
functional magnetic resonance imaging studies.
Investigators: Dr. G Venkatasubramanian, Dr.
BN Gangadhar, Dr. V Ravi, Dr. MS Keshavan,
(Funding by Wellcome Trust / DBT India Alliance)
Schizophrenia, a complex neuropsychiatric disorder, is
characterized by delusions, hallucinations, disorganized
behaviour and progressive cognitive deficits, whose
pathophysiology remains unclear. It is ranked among the top
ten disabling disorders by the World Health Organization.
A compelling hypothesis with translational potential,
investigatedintheseniorfellowshipresearch,isthat“complex
Annual Report
2013-14
interactions
between
neuroimmunological/neutrophic
factors and hippocampus might underlie the pathogenesis of
schizophrenia”. Ascertaining evidence for these pathogenetic
interactionswillenhanceourunderstandingofthisintriguing
disorderandcanpotentiallyopennoveltherapeutictargetsfor
schizophrenia. Interim findings of this research project have
demonstrated deficient serum BDNF in antipsychotic-naïve
schizophrenia patients and as well as trend level significant
deficiency in HR subjects partially support the postulated
endophenotypes basis of BDNF in schizophrenia. In subjects
athighriskforschizophrenia,therewasapathophysiologically
relevant and significant correlation between plasma IL-6 and
hippocampus activation during the performance of learned
irrelevancetask.
cellswerelysedandclearedbyadditionoflysingsolution.The
remaining pellet obtained after centrifugation was suspended
instainingsolutionandanalysedbyflowcytometry.
33. Translational
Research
on
the
Neuroimmunopathology
of
Schizophrenia
[Center of Excellence and Innovation in
Biotechnology – Institutional Programme
Support].
Investigators:
Dr.
Ganesan
Venkatasubramanian, Dr. BN Gangadhar, Dr. V
Ravi, Dr. SK Shankar, Dr. DK Subbakrishna, Dr.
Anita Desai, Dr. Anita Mahadevan, Dr. Shivarama
Varambally, Dr. Jitender Saini, Dr. Mariamma
Philip (Funding by DBT)
35. Indo-US training program on chronic noncommunicable disorders (CNCD) and diseases
across the life span. Investigator: Dr. Mathew
Varghese (Funding by Fogarty International
Center)
Schizophrenia is perhaps one of the most puzzling mental
disorders whose etiopathogenesis is yet to be ascertained.
Substantial research evidence from various lines of studies
argues towards a compelling role for gene-environment
interaction as a promising causal model for schizophrenia.
genetic, immunological as well as epidemiological studies
implicate a robust role for immune-mediated pathogenesis
in schizophrenia. Indeed, immune disturbances mediated
pathogenesis is among the most comprehensive & integrative
models to understand the pathogenesis of schizophrenia.
Immune mediated pathogenesis has also been described
in bipolar disorder. This research on one of the component
projects on DBT-Center of Excellence for Translational
Research on the Neuroimmunopathology of Schizophrenia
seeks to evaluate diagnostic utility of immune markers in
psychosestodifferentiateschizophreniapatientsfromthoseof
bipolardisorderandhealthycontrols.
37.
As a part of preliminary analysis, 15 antipsychotic-naïve
schizophreniabloodsamplesandequalnumberofcontrolswere
subjectedtoadvancedFACSanalysis.About100uloftheblood
was labelled with antibodies against CD3, CD16, CD56, CD4,
CD8,CD25,CD28,CD127,andCD45indimlightconditions.
This was followed by incubation in 40ºC for 20 min. RBC
Fresh brain tissues and CSF from clinically characterized
autopsied cases of schizophrenia are being studied by
proteomic approach to identify candidate biomarkers. In
additioncytokine-chemokinelevelsarebeinganalysedinCSF
bybeadassay.
34. Default mode network as a predictor of cognitive
ageing. Cognitive science research initiative
(CSI). Investigators: Dr. Varghese M, Dr. John
JP, Dr. Jain S, Dr. Bagepally BS (Funding by DST)
36. Shradha: A multimodel interface to desktop for
elderly user group. Investigators: Dr. Sreekanth
NS, CDAC, Bangalore, External consultant, Dr.
Varghese M (Funding by DST)
Targeted generation and interrogation of cellular
models and networks in neuro-psychiatric
disorders using candidate genes. Investigators:
Dr. Sanjeev Jain, Dr. Preeti Joshi, Dr. M Panicker,
NCBS, Bangalore, Dr. Mathew Verghese, Dr.
Meera Purushottam, Dr. Odity Mukherjee,
NCBS, Bangalore, Dr. Mukund Thattai, NCBS,
Bangalore, Dr. Ashwin Sheshasayee, NCBS,
Bangalore (Funding by DBT)
Aspartoftheproject,10casesand10controlshavebeensampled.
Protocol for generation of lymphoblastoid cell lines from
peripheral blood lymphocytes has been standardised. Twenty
LCLlineshavebeengenerated.Preliminarytranscriptomedata
by RNA sequencing has been generated for 2 LCL lines. The
methodforgeneconversionisbeingstandardised.
38. Genetics of movement disorders. Investigators:
Dr. Sanjeev Jain, Dr. Pramod Pal, Dr. Meera
Purushottam (Funding by ICMR)
Patients and relatives are counselled prior to collecting the
bloodsampleforgeneticdiagnosisofHuntington’sdiseaseand
dominantataxias,ofwhichSCA1,2,3arebeingpredominantly
Annual Report
2013-14
tested for. Tables below give the numbers who have tested
positive of the total cases tested. After adequate samples are
collected,thegenotypeinformationwillbecorrelatedwiththe
availableclinicalinformationforrecruitedsubjects.Haplotype
analysis is being done for Huntington’s disease to look for
regionspecificgeneticassociations.
IMPRESSION
CLINICAL
IMPRESSION
Degenerative
Ataxias
Huntington’s
disease
NUMBERSSAMPLED/NUMBEROF
POSITIVES
NUMBERSSAMPLED/NUMBEROF
POSITIVES
40. Novel gene modifiers of penetrance of Alzheimer’s
disease in carriers of apolipoprotein E (APO E)
E4 alleles. Investigators: Dr. Sanjeev Jain, Dr.
Mathew Varghese, Dr. Odity Mukherjee (Funding
by ICMR)
Individualswithdiagnosisofdementiahavebeensampledalong
withagematchedcontrolsubjects.TheDNAisolatedfromblood
hasbeenusedforgenotypingattheAPOE,CLUandPICLMloci.
ThefindingsindicateassociationforAPOEbutnottheCLUand
PICALMpolymorphisms.Tablewithresultsbelow:
90/29
34/21
Rangeof
RangeofNormal
Expandedallele
S.
Clinical
No.of
alleleRepeatsin
No Impression Positives
Repeatsin
positivesamples
positivesamples
1.
SCA1
12
21-31
38-58
2.
SCA2
13
19
31-57
3.
SCA3
1
21
72
4.
SCA12
3
10
5.
HD
21
13-24
40-69
39. A multimodal imaging-genomics approach to
investigating the link between impaired word
generation and aberrant glutamatergic function
in schizophrenia. Investigators: Dr. John P John,
Dr. Sanjeev Jain, Dr. Bindu M Kutty, Dr. Jitender
Saini (Funding by DST — CSI)
Schizophrenia subjects were shown to have excessive functional
magnetic resonance imaging (fMRI) brain oxygen-level
dependent (BOLD) activations and deficient deactivations
underlying their impaired performance of word generation in
our previous research. On the basis of existing findings, these
aberrant activations/deactivations may be understood to reflect
an underlying hyperglutamatergic state secondary to NMDAhypofunction in the GABA-ergic interneurons in schizophrenia.
Thus, using aberrant activations/deactivations during word
generationasaputativeneurophysiologicalmarkerofunderlying
glutamatergic dysfunction in schizophrenia, the investigators
propose to investigate its neurophysiological, neurochemical,
neuroanatomical and molecular genetic correlates, using a
multi-modal imaging-genomics approach for obtaining in
vivo confirmation of the role of glutamate in schizophrenia
pathophysiology.Thestudyproposestousemulti-modalimaging
toolsincludingfMRI,magneticresonancespectroscopy(MRS)at
rest and functional MRS, P50 suppression paradigm, diffusion
tensorimaging(DTI)in32gradientdirections;aswellasmolecular
geneticapproachestostudytheDTNBP1andNRG1genes.
Allparticipants(AD,n=243,control,n=164)
Genotype
Frequency
23
APOE
24
33
34
44
Allele
frequency
E2
E3
E4
CC
CLU
rs1113600 CT
TT
Allele
frequency
C
T
PICALM AA
rs3851179 GA
GG
Allele
frequency
A
G
Gene,SNP
41.
11(0.04)
11(0.04)
131(0.53)
75(0.30)
15(0.06)
2n=486
Control(n,
ChiP
%)
Square
17(0.10)
1(0.006)
<0.001* 32.68
123(0.75)
22(0.13)
1(0.006)
2n=328
0.04
0.71
0.23
136(0.56)
92(0.38)
15(0.06)
2n=486
0.05
0.86
0.07
85(0.51)
63(0.38)
16(0.1)
2n=328
0.74
0.25
47(0.193)
104(0.428)
92(0.379)
2n=486
0.71
0.29
32(0.195)
79(0.482)
53(0.323)
2n=328
0.40
0.59
0.43
0.56
AD(n,%)
<0.001* 34.79
0.48
1.45
0.25
1.30
0.54
1.21
0.54
0.46
Prevalence of anxiety and depression among
pregnant women and association with antenatal
healthcare utilization, antenatal health behaviour
and with pregnancy outcomes – a prospective
study. Investigators: Dr. Chandra PS, Dr.
Satyanarayana VA, Dr. Kavita Jangam (Funding
by DHR/ICMR)
The aim of the study is fourfold. The primary objective is to
prospectively assess both anxiety and depression among 650
womenfromtheirfirsttrimesterofpregnancytothethird,and
within4weeksofchildbirth.Inaddition,variouspsychosocial
Annual Report
and psychiatric factors that might be a risk factor for poor
mentalhealthduringpregnancywillbesystematicallyassessed.
Next,theimpactofmentalhealthandpsychosocialfactorson
antenatalhealthbehaviourssuchasantenatalclinicattendance,
immunizationduringpregnancy,anemiaandnutritionwillbe
assessed.Finally,therelationshipbetweenanxiety/depression
and pregnancy outcomes controlling for other psychosocial
and obstetric variables will be examined. The study will be a
prospective longitudinal study of perinatal depressive and
anxiety symptoms among women in three slums of urban
Bangalore.Thepopulationofthestudywillcomprisepregnant
women. A cohort of 650 consecutive eligible and consenting
women will be studied from the first trimester of pregnancy
to six weeks of the postpartum period. This is a very recently
fundedprojectandthestudyrelatedactivitieswillbeinitiated
shortly.
42. Incidence and determinants of metabolic
complications of antipsychotics in community
dwelling schizophrenia patients in India.
Investigators: Dr. Gangadhar BN, Dr. Naveen
Kumar C, Dr. Rita Christopher (Funding by
American Psychiatric Association)
The study is aimed at determining the incidence and
determinants of metabolic complications of antipsychotics
amongpatientswithschizophrenialivinginaruralcommunity.
Among the 250 patients and 270 healthy controls who were
recruited from Turuvekere, the metabolic parameters were
determined and genotyping for -759C/T polymorphism of
5HT2creceptor,-2548G/ApolymorphismofLeptingene,and
-1291C/Gpolymorphismforalpha2adrenergicreceptorswere
carriedout.Inaddition,estimationofserumleptinlevels,serum
insulin levels and serum prolactin levels were also completed
bothatbaselineandat6monthsoffollow-up.
43. Neural correlates of symptoms provocation in
drug-naïve patients with obsessive compulsive
disorder – A functional MRI study. Dr. S Mahavir
Agarwal. Guides: Dr. CR Chandrasekar, Dr. G
Venkatasubmramanian.
44. Rapid assessment of mental health and needs
and planning of mental health services for the
transgender (Hijra) community. Dr. Satish
Kumar Budania. Guides: Dr. Shekar Seshadri,
Dr. BM Suresh.
45. Household cost of dementia – An exploratory
study, an estimation of costs for the care of
2013-14
dementia to families in an urban setting. Dr.
Vinutha R. Guides: Dr. Srikala Bharath, Dr.
Girish N Rao
46. Predictive
value
of
fluoxotine
induced
early antidepressant improvement to late
antidepressant improvement in depression. Dr.
Shree Mishra. Guides: Dr. RS Pandey, Dr. Naveen
Kumar C
47. Association of plasma protein clusterin with
Alzheimer’s disease. Dr. Kavita Nagpal. Guides:
Dr. Mathew Varghese, Dr. Sanjeev Jain
48. Bipolar disorder comorbidity in patients with a
primary disgnosis of GOD. Dr. Gayathri Saraf.
Guides: Dr. YC Janardhan Reddy, Dr. BM Suresh.
49. A study on outcome of opioid dependence
treatment. Dr. Sissira VS. Guides: Dr. Prabhat K
Chand, Dr. Pratima Murthy.
50. A study of clinical correlates of high suicidal intent
among psychiatric inpatients. Dr. Hemendra
Singh. Guides: Dr. Prabha S Chandra, Dr. Senthil
K Reddi.
51.
Relationship
between
cognitive
function
and metabolic parameters in patients with
schizophrenia. Dr. Kapil Jhamnani. Guides: Dr.
G Venkatasubramanian, Dr. BN Gangadhar
52.
Prevalance and correlates of chronic paion with
alcohol dependence syndrome. Dr. Jitendra Rohilla.
Guides: Dr. Geetha Desai, Dr. Prabhat K Chand
53. Integrated brief tobacco cessation and alcohol
intervention in a primary health care setting in
Karnataka. Dr. Sabari Sridhar OT. Guides: Dr.
Pratima Murthy, Dr. Kishore Kumar
54. An exploratory study of the link between Adenssine
Deaminase level and sleep abnormalities in
schizophrenia. Dr. Sunil Kumar. Guides: Dr.
John P John, Dr. Sanjeev Jain
55. Study of gastrointestinal symptoms and atopy
in children with autism spectrum disorder. Dr.
Suresh VC. Guides: Dr. John Vijay Sagar, Dr.
Geetha Desai
Annual Report
2013-14
56. Heritability of substance alcohol and nicotine
seeking behavior. Dr. Prabhu Kiran. Guides: Dr.
Sanjeev Jain, Dr. Prabhat K Chand
57.
Social cognition in patients with bi-polar disorder
in remission and its association with their
functioning. Dr. Punith M. Guides: Dr. Jagadisha,
Dr. YC Janardhan Reddy
58. Retrospective evaluation of the course of bipolar
disorder in hospitalized patients. Dr. Sushma
BR. Guides: Dr. Sanjeev Jain, Dr. YC Janardhan
Reddy
59. Apolipoprotein E-Epsilon frequency and late
onset psychosis. Dr. Kumbhar Mahesh Ananda
Rao. Guides: Dr. Srikala Bharath, Dr. Sanjeev
Jain
60. Stability of social cognitive deficits in patients
with schizophrenia and its correlates – A
prospective study. Dr. Shashidhara HN. Guides:
Dr. Jagadisha, Dr. Naveen Kumar C
61.
The relationship of OCD to reproductive life
events among women with OCD. Dr. Imon Paul.
Guides: Dr. Prabha S Chandra, Dr. YC Janardhan
Reddy
62. Repititive transcranial magnetic stimulation
as add on treatment for schizophrernia – A
randomized double blind sham controllers study.
Dr. Rajendra KM. Guides: Dr. Ravi S Pandey, Dr.
Jagadisha
63. Vulnerability
for
schizophrenia
clinical
neurocognitive
and
neuroimaging
correlates. Dr. Virupaksha HS. Guides: Dr G
Venkatasubramanian, Dr. PT Sivakumar
64. Schizophrenia and body constitution (prakrit) :
An exploration study. Dr. Rashmi A. Guides: Dr.
BN Gangadhar, Dr. Shivaram V
65. Longitudinal course of cannabis induced
psychotic disorders. Dr. Shah Dharav Sunil.
Guides: Dr. Prabhat K Chand, Dr. Pratima Murthy
66. Differentiating schizophrenia and bipolar
affective disorder – A study of functional
brain symmetry amd emotion recognition. Dr.
Saravanakumar A. Guides: Dr. BN Manjula Devi,
Dr. G Venkatasubramanian
67. Word generation and sentence formation: a
lesion-based multimodal imaging study. Dr.
Aniruddh Narasimha. Guides: Dr. John P John,
Dr Sanjeev Jain, Dr. Paritosh Pandey, Dr.
Jitender Saini, Dr. Senthil Reddi
68. An exploratory study of the link between white
matter integrity and serum levels of S100-B, a
peripheral biomarker of neuronal integrity in
schizophrenia. Dr. Nitin Ambekar. Guides: Dr.
John P John, Dr. Sarada Subramanian
Schizophrenia is a severe mental illness with significant
anatomical disruption in white matter integrity. Diffusion
tensor imaging, can measure the white matter abnormality
intermsoffractionalanisotropy.Studieshaveshownaltered
Th2/Th1 immune response and activation of microglia and
astrocytes in schizophrenia resulting in release of certain
proteinssuchasS100-B.Measuringthisproteincouldreflect
whitematterabnormalitiesatperipherallevel.Inthisstudy,
subjects will be scanned with 3.0 Tesla MRI system and
Diffusiontensorimagewillbeacquired.Bloodwillbecollected
forassessmentofS100-Blevelsintheserumwhichwouldbe
measuredbyELISA.
69. An exploratory study of resting state brain
functional connectivity and its association with
S100B in major depression. Dr. Venkata Lakshmi
Narasimha. Guides: Dr. John P John, Dr. Sarada
Subramanian
Dysregulationinbrainregionsassociatedwithaffectiscentral
in the etiology of Major Depressive Disorder (MDD). This
functionaldisconnectivitycanresultinreleaseoffactorssuch
asS100-B.
Subjectswillbescannedwith3.0TeslaMRIsysteminresting
statefor6minutesandMagneticresonanceimagingdatawillbe
acquired.SerumwillbeusedforassessmentofS100-B.ELISA
will be carried out for the assessment of above mentioned
biomarker.
Annual Report
70. Supportive CSF biomarker evidence to enhance
the specificity of criteria for diagnosis of
Alzheimer’s dementia. Dr. Chandrashekar B.
Huded. Guides: Dr. Srikala Bharath, Dr. Chandra
SR, Dr. Sarada Subramanian
This study was undertaken to validate the measurement of
biomarkersassupportiveevidenceinincreasingthespecificity
ofthecurrentdiagnosticcriteriaofAD.CSFAβ42concentration
wassignificantlylowinallADcases.Thereweredifferencesin
ratioofp-tau/t-taubetweenADcasesandcontrolgroup.The
CSF Aβ-42/ p-tau ratio showed significant differences in the
meanbetweencases(probableandpossibleAD)comparedto
normativedataindicatingthediscriminativevalueoftheCSF
Aβ-42/ P-tau ratio in differentiating AD cases from normal
controls. This study made an attempt to validate NIA-AA AD
diagnosticcriteriaintheIndianset-up.
71.
Role of copper in Alzheimer’s dementia- a
controlled study. Dr. Siddhesh S Shere. Guides:
Dr. Srikala Bharath, Dr. Sarada Subramanian,
Dr. Meera Purushottam
Understanding the molecular alterations responsible for
Alzheimer disease (AD) has become imperative in order to
developefficientstrategiesforthetherapy.Mountingevidence
suggests that copper homeostasis is disturbed in affected
individuals,leadingtooxidativestressandneurodegeneration.
Patients with Alzheimer’s Dementia who fulfill the inclusion
and exclusion criteria will be assessed on the study variables
andcomparedwithmatchedhealthycontrols.Thestudywould
provide us important insights into the role of copper in a
neurodegenerativedisorderlikeAlzheimer’sDementiaandthis
wouldhaveimplicationsfordiagnosing,severityprognosisand
therapy.
72.
Insulin resistance in Alzheimer’s dementia. Dr.
Sreelakshmi Thankappan. Guides: Dr. Srikala
Bharath, Dr. Sarada Subramanian, Dr. Preeti
Sinha, Dr. Meera Purushottam
Alzheimer’s dementia is considered as the most common
dementia worldwide. Disturbances in the insulin signalling
pathwaysisconsideredastheconnectinglinkbetweendiabetes
andAlzheimer’sdementia.
Thestudyproposestofindtherelationbetweeninsulinresistance
andAlzheimer’sdementia.Thesubjectswillbeevaluatedusing
2013-14
sociodemographicprofoma,cognitivescreeningbattery(CSB),
everydayabilityscaleforIndia(EASI),clinicaldementiarating
scale(CDR).Bloodsugarandlipidprofile,insulinlevel,HbA1c,
andApoEgenotypingwillbecarriedout.
1.
Psychosocial competencies for children in
difficult circumstances. Investigator: Dr. K Sekar
(Funding by Everychild, UK)
2.
Adaptation of psychosocial support materials for
children with disabilities. Investigator: Dr. K.
Sekar (Funding by SAMA)
3.
Prevention of HIV among persons in central
prison in Karnataka. Investigators: Dr. K Sekar,
Dr. Jayashree R, Dr. Prathima Murthy (Funding
by UNODC)
4.
Promotion of mental health skills and
psychological well-being of adolescents in
schools-a district model. Investigator: Dr. Vranda
MN (Funding by District Administration, Kolar)
Theprojectaimedatpromotionofmentalhealthandpsychological
well-being of rural high schools students using teachers as
trainers.Asapartoftheproject,needassessmentwasconducted
using focus groups discussions and in-depth interviews with
teachers, mental health professionals, educational officers,
studentsandtheirparents.Thishelpedtounderstandtheissues
ofadolescentstobeaddressedinthepromotivementalhealthand
psychologicalwell-beingmodules.Basedontheneedassessment
and triangulation with existing literature, a draft manual was
developed. The draft manual was field tested with 288 higher
primaryandhighersecondaryschoolteachersfrom6taluksof
Srinivasapura, KGF, Kolar, Malur, Mulbgal, and Bangarapet
of Kolar District. In the training programme, teachers were
trainedonfacilitatorymethods,conceptsofpromotionofmental
healthskillsandwell-being,useofthemodules,andplannedfor
implementationoftheprogrammeintheclassovertheyear.A
totalofsixworkshopswereconducted.Currentlytheexpertpeer
reviewfordraftmanualisunderway.Thesuggestionsofthepeer
reviewers and teachers will be included in final manual before
printing.Theprogrammewillbeimplementedintheschoolsby
trainedteachersinthepresentacademicyear(May2014)forone
year.
Annual Report
5.
6.
2013-14
Efficacy of brief yoga programme for caregivers
of outpatients with schizophrenia. Investigators:
Dr. Shivaram V, Dr. Md. Ameer Hamza (Funding
by AYUSH, MH&FW)
Developing training manual on adolescence
sexuality, reproductive health and Gender
discrimination to capacitate post graduate Social
Work students trainees in India. Investigators:
Dr. Md. Ameer Hamza, Dr. R Parthasarathy, Dr.
N. Janardhana (Funding by ICMR)
The main objective of the project was developing culture
sensitive training manual to educate adolescents on sexuality
and reproductive health. Mixed method was used during
the development of this manual. Review of literature was
collected on adolescence sexuality, reproductive health and
gender discrimination during the first three months from
varioussources.Followedbythisfocusgroupdiscussionswas
conductedwithexpertsfromalloverIndiatodevelopamanual
withparticipatorytrainingmethodology.Theparticipantswere
selected based on their experience in the areas of teaching,
research, publication, or research projects. The draft manual
was prepared with the help of these experts. Subsequently,
a review of university syllabi of 12 post graduate schools of
SocialWorkwasconductedtoidentifylacunaeintheexisting
coursecontent.Thedraftmanualwaspreparedwithnecessary
modifications and need of the post graduate social work
students.The6postgraduatesocialworkcollegesofBangalore
Citywerecontactedfortheirwillingnesstosendtheirstudents
for the training programme. From each college, 15 students
were randomly selected to participate in a three-day training
programme.Duringthetrainingprogramme,thestudentswere
trained in areas of sexuality, reproductive health and gender
discrimination. In the total of three workshops of three days
durationeach,thetrainingprogrammeswerefieldtestedand
finalized.Thedraftmanualwasmodifiedaccordingtotheneed
and requirement of the workshop participants. Subsequently,
feedback from the workshop participants were incorporated
in the manual. The structured manual was prepared and the
titlemodifiedfromadolescencesexuality,reproductivehealth
andgenderdiscriminationtoreproductivehealth,adolescence
sexuality and gender equality, based on the reviewers’
suggestion.
7.
Development of the counseling manual and
Capacity building for the counselors dealing with
relationship issues of FSWs. Investigators: Dr. N
Janardhana, Dr. Md. Ameer Hamza, Dr. Jayshree
Ramakrishna, Dr. N Krishna Reddy (Funding by
Karnataka Health Promotion Trust)
The main aim of the project was to develop a counseling
training manual and capacity building of counselors dealing
with relationship issues of FSWs. The need assessment
was carried out with counselors, staffs of KHPT, and FSWs
through interviews and Focus Group Discussions. Based on
these findings, the major themes were taken for training and
manual development. The training programme and hand
holding support for counselors were carried out in Bagalokot
andBijapurdistricts.Inthepilotphaseoffirstsixmonths,the
manual was drafted and field tested in the later stage. Nearly
18counsellorsweretrainedandreceivedhand-holdingsupport
in the field. The draft manual was given to the experts in the
fieldforreview.Thenecessarymodificationsweremadebased
onthereviewerscomments.Thefinalmanualwasgiventothe
fundingagencyforprint.
8.
Psychosocial interventions for children in
difficult circumstances under the care and
protection of Child Welfare Committee,
Bangalore. Investigators: Dr. N Janardhana, Dr.
BP Nirmala, Dr. N Krishna Reddy, Dr. Md. Ameer
Hamza, Dr. H Uma, Dr. Roopesh, Dr. John Vijaya
Sagar (Funding by KHPT, Govt. of Karnataka)
The main aim of the project is to provide psycho-social
interventions for children under care and protection and
counseling training for counselors. This particular project is
fundedbyKarnatakaStateIntegratedChildProtectionSociety,
Dept. of Women and Child Development, Govt. of Karnataka.
Through this project psycho-social interventions are being
providedtochildrenatShishuGruhas(Governmenthomes)and
childrenwhocomeforcareandprotectionthroughchildwelfare
committee. Preventive and promotive mental health activities
arebeingcarriedoutintheinstitutions.Childrenwhoareinneed
ofcurativetreatmentarebeenreferredtoChildandAdolescent
Psychiatry OPD. Supervision and hand-holding support is
ongoingforcounselorsinGovernmentChildrenHomes.
9.
A Study on psychosocial correlates and problems
of caregivers of person living with cancer.
Investigators: Dr. A Thirumoorthy (Funding by
ICSSR)
This study aims to assess the quality of life, coping styles,
the burden experienced and the social support available to
caregiversofpersonslivingwithcancer.
Annual Report
10.
Psychosocial problems of patients with Parkinson’s
disease. Investigator: Dr. Prakashi Rajaram
11.
Childhood abuse and self harm among
women
hospitalized
for
psychiatric
disorders. Investigator: Dr. Kavita Jangam,
Dr. Muralidharan K, Dr. N Janardhana, Dr.
Thennarasu (Funding by NIMHANS)
Themainaimoftheprojectistostudytheprevalenceofchildhood
physical,sexual,emotionalabuse,intimatepartnerviolenceand
selfharmamongwomenwithpsychiatricdisorders.Theproject
wasinitiatedwithNIMHANSfundinginJune2013.Thesample
forthestudywascollectedfromNIMHANS.Womenabovethe
ageof18to50wererecruitedforthestudyfrombothinpatient
andoutpatientsetting.Anonclinicalsampleofwomenwasalso
recruitedforthecomparisonpurpose.Totalsamplecomprised
200womeninpatients,409womenoutpatientsand100nonclinical sample of women. Data collection was completed in
April 2014 and currently, data analysis and report writing
is in progress. The report of the project will be submitted to
NIMHANSinJune2014.
12.
wide range of issues of children in difficult circumstances,
counselingaspects,childprotectionmechanism,legalaspects,
and care for these children. These topics were introduced
in the training programmes based on the nature of work of
childprotectionpersonnellikecounselors,protectionofficers,
probation officers, social workers, house parents, institution
heads from all the districts of Karnataka. Totally 13 training
programmesconductedintheDepartmentcoverednearly425
childprotectionpersonnel.Allthetrainingprogrammeswere
completed,andthehandbookofcounselingisbeingprepared.
15.
Intensive case management for persons with
severe alcohol dependence – A feasibility study.
Mr. Arthur Julian Anthony Joseph. Guides: Dr.
R. Dhanasekara Pandian, Dr. Pratima Murthy
16.
Efficacy of psychosocial intervention with siblings
of persons with schizophrenia. Mr. Amaresha.
Guides: Dr. D Muralidhar, Dr. DK Subbakrishna
(Funding by Wellcome Trust/DBT India Alliance)
17.
Psychosocial needs, distress, social support,
quality of life and functionality of newly diagnosed
malignant brain tumor patients. Mr. Biruduraju.
Guide: Dr. NK Krishna Reddy , Dr. Vani Santosh,
Dr. Paritosh Pandey (Funding by DBT )
An investigation into the patterns of out patient
follow up treatment and the influencing factors
for follow-up among patients with severe mental
illness in NIMHANS: A mixed method study.
Investigators: Dr. Kavitha Jangam (NIMHANS
intramural funding)
13.
Comparision
of
antipsychotics
for
nonneurological adverse effects- Pilot naturalistic
study.
Investigator:
Dr.
Kavita
Jangam
(NIMHANS intramural funding)
14.
Capacity building and counselling training
programme for field functionaries of Integrated
Child
protection
Scheme
in
Karnataka.
Investigators: Dr. N Janardhana, Dr. K Sekar,
Dr. R Parthasarathy, Dr. D Muralidhar, Dr.
Shekhar P Seshadri (Funding by Karnataka
State Integrated Child Protection Society, Dept.
of Women and Child Development, Govt. of
Karnataka)
Themainaimoftheprojectwastoconductcapacitybuildingand
counselingtrainingprogrammeforchildprotectionpersonnel
in Karnataka and to develop a Handbook on Counseling.
Initiallytopicswerepreparedforcounselingtrainingcovering
2013-14
Psychopharmacology
1.
Electroconvulsive seizure-induced neuroplasticity
changes in the rat brain. Investigators: Dr.
Chittaranjan Andrade, Dr. Sumantra Chatarji, Dr.
BK Chandrasekhar Sagar, Ravi Prabhakar Hegde
(Funding by DBT and ICMR)
Neuroplasticity in the brain, which is influenced by inputs
from environment, is a complex phenomenon which
includes neurogenesis, new synapse formation, dendritic
arborization, long-term potentiation, long-term inhibition,
andotherphenomena.Plasticityoccursonavarietyoflevels,
ranging from cellular changes involved in learning, to largescale changes involved in cortical remapping in response to
injury. Neuroplasticity changes also underlie improvement
in or recovery from depression, stroke, and possibly certain
neurodegenarative diseases. Neuroplasticity changes have
been proposed as a mechanism of action of electroconvulsive
therapy(ECT).Electroconvulsiveshock(ECS)hasbeenshown
to induce nerve cell proliferation in the hippocampus. The
Annual Report
2013-14
Investigators: Dr. Vandana VP, Dr. Preeti Sinha,
Dr. M Jayaram Dr. Pamela Enderby, University
of Sheffield (NIMHANS intramural funding)
presentstudyhasbeendesignedtodeterminetheroleofECS
insynaptogenesisintherathippocampus.
2.
3.
Study of visuospatial memory in an animal model
of ECT. Investigators: Dr. Chittaranjan Andrade
Meta-analysis of ar/modafinil in schizophrenia.
Investigator: Dr. Chittaranjan Andrade
The meta-analysis indicated that ar/modafinil produced a
smallimprovementinnegativesymptomswithoutfavorablyor
adverselyinfluencinganyotheraspectofpsychopathologyand
withoutcausingsignificantadverseoutcomes.
4.
Efficacy of herbal cognition enhancers in learning
and ECS-induced amnesia. Investigator: Dr.
Chittaranjan Andrade
The study indicated that the herbal formulations improved
learningandreducedECS-inducedretrogradeamnesticdeficits.
5.
Investigation of ECS-induced oxidative stress
and retrograde amnesia. Investigator: Dr.
6.
A study to evaluate the effectiveness of an
educational module on knowledge about,
experiences with, and attitudes towards
antidepressant
drugs
in
antidepressantnaïve depressed patients. Investigators: Dr.
The educational module significantly improved knowledge
without influencing attitudes or outcomes. Patients receiving
educationexperienced/noticedmoredrugadverseeffects.
7.
Alteration of heart rate variability and cardiac
electrophysiological variables in a rodent model
of brain stimulation. Mr. Nagendra Madan Singh.
Guides: Dr. Chittaranjan Andrade, Dr. Jagadisha
T (Funding by ICMR)
This study mathematically models heart rate variability as a
functionofdifferentelectricaldosesinananimalmodelofECT.
Speech production deficits are frequently associated with the
use of psychotropic drugs, with the symptoms manifesting
within three to six months or within an year of initiation of
medication. Majority of these symptoms are associated with
the use of old generation antipsychotics. These side effects
occur when antipsychotic drugs are taken in isolation or
combined with other medications. At present, there is a lack
ofwell-controlledstudiesexaminingantipsychoticmedicationrelated speech outcomes, particularly as associated with
atypical antipsychotic drugs. The objective of the proposed
researchistoprovidetheprevalenceofadversesideeffectson
speech production from use of atypical antipsychotic drugs;
to determine if impairments in speech motor function were
specific to any atypical antipsychotic drug and to see if there
areanychangesinspeechproductioncharacteristicsassociated
withuseofatypicalantipsychoticdrugaloneorincombination
withantidyskineticsliketrihexyphenydylandbenzodiazepine.
Theresultsofthestudymaypossiblyrevealthemedicationsthat
mayormaynotbeassociatedwithspeechproductiondeficits
andalsothetypeofspeechproductiondeficitsassociatedwith
use of atypical antipsychotic drugs. By adding a thorough
knowledge of adverse drug effects to psychopharmacological
training,professionalscanprovidehigherqualitymentalhealth
care,providepositivelongtermoutcomeswithbettertreatment
efficiencyandreductioninoverallhealthcarecosts.
2.
The scope of this study is to focus on the articulatory
kinematicsinbothbulbaronsetandspinalonsetpatientswith
Amyotrophic Lateral Sclerosis. Patients and matched healthy
controlsarebeingrecruitedandtestedonaseriesoftasksusing
thearticulograph.
Ayurveda
1.
Clinical evaluation of brahma rasayana in the
management of “Manasamandata” (Mental
Retardation) – An open clinical Trial.
2.
Clinical evaluation of a Comprehensive Ayurvedic
intervention in the management of Manodwega
(GAD).
Speech Pathology & Audiology
1.
Articulatory kinematics in patients with amyotrophic
lateral sclerosis. Investigators: Dr. BK Yamini, Dr. N
Shivashankar, Dr. A Nalini (Funding by DBT)
Prevalence and nature of speech disorders
in persons on atypical antipsychotic drugs.
Annual Report
3.
Clinical evaluation of sarasvata ghrita in the
management of cognitive deficit.
4.
5.
2013-14
6.
A comparative study of ayurvedic treatment vs
allopathic treatment inpatients with moderate to
severe dementia (Smriti bramsa).
Ayurvedic coded drug (AYUSH MANAS) in
the management of Manasa Mandata (Mental
Retardation).
7.
Effectiveness of the role of astangalavana and
srikhandasava as add on treatment on madatyaya
(Alcohol Dependence) – An open level clinical trial.
Clinical evaluation of panchagavya ghrita and
jyotishmati taila in the management of vishada
(Depression).
8.
Clinical evaluation of ayurvedic intervention in
the management of Gridhrisi vata (Sciatica).
Number of Research Projects
A. Newly Sanctioned Projects
i) National
36
ii) International
02
B Ongoing Projects
i) National
ii) International
iii) Training Schemes
C.COMPLETED & CLOSED
220
29
02
Total
Projects
Total Amount Involved
(in `)
Total Amount Per
Annum (in `)
8,92,36,824.00
35,49,333.00
445,70,816.00
35,49,333.00
52,68,44,695.00
3,70,26,607.00
3,40,56,294.00
19,13,87,612.00
2,09,31,012.00
14,09,483.00
289
69,07,13,753.00
26,18,48,256.00
15
1,32,45,681.00
46,08,274.00
38
251
Annual Report
2013-14
PhotoCourtesy:JasminMaitreya
Annual Report
Publications
A. INTERNATIONAL JOURNALS
1.
2.
3.
4.
Abhishekh HA, Kumar NC, Thirthalli J, Chandrashekar
H, Gangadhar BN, Sathyaprabha TN. Prolonged reaction
to mental arithmetic stress in first degree relatives of
schizophrenia patients. Clin Schizophr Relat Psychoses.
2013; 1-14.
Abhishekh HA, Nisarga P, Kisan R, Meghana A, Chandran
S, Raju T, Sathyaprabha TN. Influence of age and gender
on autonomic regulation of heart. J Clin Monit Comput.
2013; 27: 259-264.
Abhishekh HA, Thirthalli J, Manjegowda A, Phutane
VH, Muralidharan K, Gangadhar BN. Ictal EEG fractal
dimension in ECT predicts outcome at 2 weeks in
schizophrenia. Psychiatry Res. 2013; 209: 155-159.
Agarwal SM, Shivakumar V, Bose A, Subramaniam A,
Nawani H, Chhabra H, Kalmady SV, Narayanaswamy
JC, Venkatasubramanian G. Transcranial direct current
stimulation in Schizophrenia. Clin Psychopharmacol
Neurosci. 2013; 11: 118-125.
5.
Amaresha AC, Arthur JAJ, Venkatasubramanian G. Letter
to the editor. Intl J Soc Psychiatry. 2013; 59: 619-620.
6.
Anadure RK, Nagaraja D, Christopher R. Plasma factor
VIII in non-puerperal cerebral venous thrombosis: A
prospective case-control study. J Neurol Sci. 2014; 339:
140-143.
7.
Andrade C. Antenatal exposure to selective serotonin
reuptake inhibitors and duration of gestation. J Clin
Psychiatry. 2013; 74: e633-e635.
8.
Andrade C. Antidepressant use in pregnancy and risk of
autism spectrum disorders: a critical examination of the
evidence. J Clin Psychiatry 2013; 74: 940-941.
9.
Andrade C. Antidepressants and testicular cancer: cause
versus association. J Clin Psychiatry 2014; 75: e198-e200.
10.
Andrade C. Augmenting selective serotonin reuptake
inhibitors with clomipramine in obsessive-compulsive
disorder: benefits and risks. J Clin Psychiatry. 2013; 74:
e1128-e1133.
2013-14
11.
Andrade C. Famotidine augmentation in schizophrenia:
hope or hype? J Clin Psychiatry 2013; 74: e855-e858.
12.
Andrade C. Learning from history: How to swallow a pill.
J Clin Psychiatry 2013; 74: e949-e951.
13.
Andrade C. Levothyroxine in psychiatry: issues related to
absorption after oral dosing. J Clin Psychiatry 2013; 74:
e744-e746.
14.
Andrade C. Low dose amisulpride and elevation in serum
prolactin. J Clin Psychiatry 2013; 74: e558-e560.
15.
Andrade C. Primary prevention of cardiovascular events
in patients with major mental illness: a possible role for
statins. Bipolar Disord. 2013; 15: 813-823.
16.
Andrade C. Selective serotonin reuptake inhibitor drug
interactions in patients receiving statins. J Clin Psychiatry
2014; 75: e95-e99.
17.
Andrade C. Signal to noise ratio, variability, and their
relevance in clinical trials. J Clin Psychiatry 2013; 74:
479-481.
18.
Andrade C. Transcranial direct current stimulation for
refractory auditory hallucinations in schizophrenia. J
Clin Psychiatry 2013; 74: e1054-e1058.
19.
Aniruddha TJ, Arivazhagan A, Chandramouli BA.
Supratentorial extradural hematoma secondary to
intracranial hypotension following spinal cerebrospinal
fluid release: A case report and review of literature.
Neurol Asia. 2013; 18 : 33-336.
20.
Anish C, Dhanasekara P, Suresh B, Thennarasu K, Reddy
YCJ. Clinical predictors of family accommodation in
obsessive-compulsive disorder: a study from India. Int J
Psychiatr Clin Prac. 2013; 17: 38-38.
21.
Arimappamagan A, Somasundaram K, Thennarasu K,
Peddagangannagari S, Srinivasan H, Shailaja BC, Samuel
C, Patric IR, Shukla S, Thota B, Prasanna KV, Pandey
P, Balasubramaniam A, Santosh V, Chandramouli BA,
Hegde AS, Kondaiah P, Rao MRS. A fourteen gene GBM
prognostic signature identifies association of immune
response pathway and mesenchymal subtype with high
risk group. PLoS One. 2013; 8: e62042.
Annual Report
22.
23.
2013-14
Arivazhagan A, Subhas K, Mohammed MA, Arvinda HR,
Paritosh P. Successful surgical management of vertebral
artery aneurysm in a patient with Takayasu disease with
a single vessel intracranial circulation: A case report and
literature review. Neurosurgery Quarterly 2014; doi:
10.1097/WNQ.0b013e3182a2fb33
Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg
MF, Kunnath-Velayudhan S, Carreño LJ, Venkataswamy
MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z,
Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen
N, Besra GS, Porcelli SA. A single subset of dendritic cells
controls the cytokine bias of natural killer T cell responses
to diverse glycolipid antigens. Immunity. 2014; 40: 105-116.
24.
Arumugham SS, Reddy YC. Commonly asked questions
in the treatment of obsessive-compulsive disorder. Expert
Rev Neurother. 2014; 14: 151-163.
25.
Arun S, Sarwat N, Balaram T, Thennarasu K, Arivazhagan
A, Sampath S, Vani S, Paturu K. Therapy resistance and
survival in glioblastoma -the role of Stat-1. Neurooncol.
2013; 15:162-163.
26.
Aswathy PM, Jairani PS, Verghese J, Gopala S, Mathuranath
PS. Microtubule-associated protein tau genetic variations
are uncommon cause of frontotemporal dementia in south
India. Neurobiol Aging. 2013; 35: e23-e24.
27.
Aziz ZA, Saini J, Bindu PS, Sharath Kumar GG.
Demonstration of different histological layers of the
pachygyria/agyria cortex using diffusion tensor MR
imaging. Surg Radiol Anat. 2013; 35: 427-433.
28.
29.
30.
Babu CS, Satishchandra P, Mahadevan A, Pillai Shibu V,
Ravishankar S, Sidappa N, Udaykumar R, Ravi V, Shankar
SK. Usefulness of stereotactic biopsy and neuroimaging
in management of HIV-1 Clade C associated focal brain
lesions with special focus on cerebral toxoplasmosis. Clin
Neurol Neurosurg. 2013; 115: 995-1002.
Babu GN, Thippeswamy H, Chandra PS. Use of
electroconvulsive therapy (ECT) in postpartum psychosis-a naturalistic prospective study. Arch Womens Ment
Health. 2013; 16: 247-251.
Babu K, Kini R, Philips M, Subbakrishna DK. Clinical
profile of isolated viral anterior uveitis in a south Indian
patient population. Ocul Immunol Inflamm. 2013; doi:10
.3109/09273948.2013.841482 [Epub ahead of print].
31.
Babu K, Philips M, Subbakrishna DK. Perspectives of
quantiferon TB GOLD test among Indian practitioners: a
survey. J Ophthalmic Inflamm Infect. 2013; 3: 9.
32.
Bagepally BS, John JP, Varghese M, Halahalli HN, Kota
L, Sivakumar PT, Bharath S, Jain S. Relationship of
clinical and cognitive variables with brain morphometric
abnormalities in Alzheimer’s disease: a voxel based
morphometric study using 3-tesla MRI. Aging Dis. 2013;
4: 1-9.
33.
Baldawa S, Kasegaonkar P, Vani S, Kelkar G. Primary
intraventricular gliosarcoma. Clin Neuropathol. 2013;
32: 525-528.
34.
Bansal S, Ramesh VJ, Rao GS, Surve RM. Anaesthesia
and orphan disease: failed airway management in a case
of Smith-McCort Dysplasia. Eur J Anaesthesiol. 2013; 30:
775-776.
35.
Bansal S, Surve RM, Venkatapura RJ. Anesthetic
management of a paraparetic patient with multiple lung
bullae. J Neurosurg Anesthesiol. 2014; 26: 85-86.
36.
Banu H, Chakrabarthy N, Michael RJ, Kumar R, Sudhir
PM, Sharma MK, Mehrotra S. Two wheeler riding
patterns, perceptions and aggressive riding behavior
among college youth. Int J Innov Res Sci Eng Technol.
2013; 2: 4250-4256.
37.
Basagoudanavar SH, Hosamani M, Tamil Selvan RP,
Sreenivasa BP, Saravanan P, Chandrasekhar Sagar BK,
Venkataramanan R. Development of a liquid-phase
blocking ELISA based on foot-and-mouth disease virus
empty capsid antigen for seromonitoring vaccinated
animals. ArchVirol. 2013; 158: 993-1001.
38.
Benegal V, Viswanath B, Narayanaswamy JC, Jose SP,
Chakraborty V, Sankar D, Kandavel T, Kesavan M. The
efficacy of atomoxetine as adjunctive treatment for
co-morbid substance use disorders and externalizing
symptoms. Asian J Psychiatr. 2013; 6: 544-547.
39.
Benegal V. Gambling experiences, problems and policy in
India: a historical analysis. Addiction. 2013; 108: 2062-2067.
40.
Bener A, Dafeeah EE, Chaturvedi SK, Bhugra D. Somatic
symptoms in primary care and psychological morbidities
in Qatar. Neglected burden of disease. Intl Review
Psychiatry 2013; 25: 100-106.
Annual Report
41.
42.
43.
44.
45.
Bennet CN, Rajeswaran J, Christopher R, Sampath S. The
right to write: EEG neurofeedback training in frontal lobe
agraphia—a case report. J Neurother. 2013; 17: 162-165.
Bertelli MO, Salvador-Carulla L, Scuticchio D, Varrucciu
N, Martinez-Leal R, Cooper SA, Simeonsson RJ, Deb S,
Weber G, Jung R, Munir K, Adnams C, Akoury-Dirani L,
Girimaji SC, Katz G, Kwok H, Walsh C. Moving beyond
intelligence in the revision of ICD-10: specific cognitive
functions in intellectual developmental disorders. World
Psychiatry. 2014; 13: 93-94.
Bhadrinarayan V. Airway management in a child with
a large retropharyngeal mass - A lesson learned: how
conventional rules of endotracheal tube fixation can be
deceptive. Anesthesiology 2013; 119: 448.
Bhaganagare AS, Sudhendra TR, Mahadevan A. Cauda
equina aspergilloma in an immunocompetent individual: A
case report. J Craniovertebr Junction Spine. 2013; 4: 35-36.
Bhalsing KS, Saini J, Pal PK. Understanding the
pathophysiology of essential tremor through advanced
neuroimaging: a review. J Neurol Sci. 2013; 335: 9-13.
47.
Bhalsing KS, Sowmya V, Netravathi M, Jain S, Pal PK.
Spinocerebellar ataxia (SCA) type 2 presenting with
chorea. Parkinsonism Relat Disord. 2013; 19: 1171-1172.
48.
Bhalsing KS, Upadhyay N, Kumar KJ, Saini J, Yadav R,
Gupta AK, Pal PK. Association between cortical volume
loss and cognitive impairments in essential tremor. Eur J
Neurol. 2014; 21: 874-883.
49.
Bharat S, Ramakrishna J, Heylen E, Ekstrand ML.
Gender-based attitudes, HIV misconceptions and
feelings towards marginalized groups are associated with
stigmatization in Mumbai, India. J Biosoc Sci. 2014; 1-16.
50.
51.
reductase C677T polymorphism in cerebral veno-sinus
thrombosis. Clin Appl Thromb Hemost. 2014; 20: 78-83.
52.
Bhat M, Prasad C, Bindu PS, Aziz Z, Christopher R, Saini J.
Unusual imaging findings in brain and spinal cord in two
siblings with maple syrup urine disease. J Neuroimaging.
2013; 23: 540-542.
53.
Bhola P, Rekha DP, Sathyanarayanan V, Daniel S,
Thomas, T. Self-reported suicidality and its predictors
among adolescents from a pre-university college in
Bangalore, India. Asian J Psychiatr. 2014; 7: 38-45.
54.
Bindu PS, Taly AB, Kothari S, Christopher R, Gayathri
N, Sinha S, Nagappa M, Bhatt M, Bharath RD. Electroclinical features and magnetic resonance imaging
correlates in Menkes disease. Brain Dev. 2013; 35: 398405.
55.
Bindu PS, Taly AB, Sonam K, Govindaraju C, Arvinda HR,
Gayathri N, Bharath MM, Ranjith D, Nagappa M, Sinha
S, Khan NA, Thangaraj K. Bilateral hypertrophic olivary
nucleus degeneration on magnetic resonance imaging in
children with leigh and leigh-like syndrome. Br J Radiol.
2014; 87.
56.
Bücker J, Muralidharan K, Torres IJ, Su W, Kozicky
J, Silveira LE, Bond DJ, Honer WG, Kauer-Sant’anna
M, Lam RW, Yatham LN. Childhood maltreatment and
corpus callosum volume in recently diagnosed patients
with bipolar I disorder: data from the systematic
treatment optimization program for early mania (STOPEM). J Psychiatr Res. 2014; 48: 65-72.
57.
Bucker J, Popuri S, Muralidharan K, Kozicky JM, Baitz
HA, Honer WG, Torres IJ, Yatham LN. Sex differences
in cognitive functioning in patients with bipolar disorder
who recently recovered from a first episode of mania: data
from the systematic treatment optimization program for
early mania (STOP-EM). J Affect Disord. 2014; 155: 162168.
58.
Buss S, Noone ML, Tsai R, Johnson B, Pradeep VG, Salam
KA, Mathuranath PS, Verghese J. Objective cardiac
markers in dementia: Results from the Kerala–Einstein
study. Int J Cardiol 2013; 167: 595-596.
59.
Chaitanya G, Sinha S, Reddy, Madhusudhan KR,
Arivazhagan A, Rao MB, Thennarasu K, Chandramouli BA,
Satishchandra P. Dexmedetomidine anesthesia during
intraoperative electrocorticography (ecog) recording:
Bhagyavathi HD, Mehta UM, Thirthalli J. The relationship
between empathy, emotion processing and clinical insight
in remitted schizophrenia patients. Eur Arch Psychiatry
Clin Neurosci. 2013; doi: 10.1007/s00406-013-0484-2
[Epub ahead of Print].
46.
Bharath S. Carer burden in dementia: an Indian
perspective (Editorial) Neurodegenerative Disease
Management. 2013; 3: 191-193.
Bharatkumar VP, Nagaraja D, Christopher R.
Hyperhomocysteinemia and methylenetetrahydrofolate
2013-14
Annual Report
2013-14
promising, safe and enhances spike generation. Epilepsia
2013; 54: 91-92.
60.
Chand P, Thirthalli J, Murthy P. Substance use disorders
among treatment naïve first-episode psychosis patients.
Compr Psychiatry 2014; 55: 165-169.
61.
Chandra PS, Doraiswamy P, Padmanabh A, Philip M.
Do newspaper reports of suicides comply with standard
suicide reporting guidelines? A study from Bangalore,
India. Intl J Soc Psychiatry. 2013; 22: 1-8.
62.
Chandra PS, Satyanarayana VA. ‘I’m more sick than my
doctors think’: ethical issues in managing somatization in
developing countries. Intl Rev Psychiatry. 2013; 25: 77-85.
63.
Chatterjee S, Naik S, John S, Dabholkar H, Balaji M,
Koschorke M, Varghese M, Thara R, Weiss HA, Williams
P, McCrone P, Patel V, Thornicroft G. Effectiveness
of a community-based intervention for people with
schizophrenia and their caregivers in India (COPSI): a
randomised controlled trial. Lancet. 2014; 383: 13851394.
64.
Chaturvedi SK, Desai G. Measurement and assessment of
somatic symptoms. Intl Rev Psychiatry. 2013; 25: 31-40.
65.
Chaturvedi SK. Many faces of somatic symptom disorders.
Intl Rev Psychiatry. 2013; 25: 1-4.
66.
Chauhan N, Chaunsali L, Deshmukh P, Padmanabhan B.
Analysis of dimerization of BTB-IVR domains of Keap1
and its interaction with Cul3, by molecular modeling.
Bioinformation 2013; 9: 450-455.
67.
68.
69.
Cherian AV, Math SB, Kandavel T, Reddy YCJ. A 5-year
prospective follow-up study of patients with obsessivecompulsive disorder treated with serotonin reuptake
inhibitors. J Affect Disord. 2014; 152-154: 387-394.
Cherian AV, Narayanaswamy JC, Viswanath B, Guru N, George
CM, Math SB, Kandavel T, Janardhan Reddy YC. Gender
differences in obsessive compulsive disorder: Findings from a
large Indian sample. Asian J Psychiatr. 2014; 9: 17-21.
Cherian AV, Pandian D, Math SB, Kandavel T, Reddy YCJ.
Family accommodation of obsessional symptoms and
naturalistic outcome of obsessive-compulsive disorder.
Psychiatry Res. 2014; 215: 372-378.
70.
Chikkannaiah P, Mahadevan A, Gosavi M, Kangle R,
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21.
Nattala P, Murthy P, Nagarajaiah. Relapse prevention in
alcohol dependence: A family-based approach - treatment
provider’s manual. Helping persons with addiction
Manual Series 3. Bangalore: Center for Addiction
Medicine, NIMHANS, Publication 2013, No. 87, ISBN 8186436-00-X.
Annual Report
22.
23.
24.
2013-14
Rakesh G, Shivakumar V, Subramaniam A, Nawani H,
Amaresha AC, Narayanaswamy JC, et al. Monotherapy
with tDCS for Schizophrenia: A Case Report. Brain
stimulation: Basic, translational, and clinical research in
neuromodulation. 2013; 6: 708-709.
Sagar BKC, Ravindrakumar M Thakkar, Gayathri N. An
Introduction to Electron Microscopy, Department of
Neuropathology, NIMHANS, Bangalore, 2014.
Sebastian J, Hamza A, Chandra SR. Effective care giving in
Dementia (A learning module for caregivers), NIMHANS
Publication, Bangalore, 2013.
E. NEWS LETTERS-SOUVENIRS
1.
Bindu PS. Clinical clues to the diagnosis of
leukodystrophies and neurometabolic disorders. Sovenir,
ISNR-2013, 16th Annual Conference of Indian Society of
Neuroradiology Bangalore, 27 September 2013.
2.
Dhanasekarapandian, R, Antony S. Psychosocial
interventions for addiction disorders. CARE foundation
Souvenir - 2014.
3.
Gupta A. Infantile spastic hemiparesis-A case scenario,
article in Novartis monthly newsletter, December 2013.
4.
Lalitha K. (i) (a) Overview of nursing theories, 12 July
2013, 7-11 (b) Application of theories in psychiatric nursing
practice 12 July 2013, 47-56. Souvenirs, RVS College of
Nursing, Coimbatore. Sponsored by ICMR, New Delhi &
Co-sponsored by Tamil Nadu MGR Medical University,
Chennai, (ii) Recent trends in nursing research for
advanced nursing practice – A global challenge. Souvenir,
1st International Conference, PIMS, Puducherry, 26
July 2013 (iii) Nursing informatics is a new direction
in nursing. Souvenir, 25th National Conference of the
student nurses association of India and trained nurses
association of India, TNAI Gujarat TNAI Branch, Surat.
2013; 46-48 (iv) Policies and programmes for senior
citizens. Souvenir, Wake up calls – mental health & older
persons. National Conference, Dhanalakshmi Srinivasan
College of Nursing, Perambalur, Tamil Nadu, 12 October
2013 (v) Value based education in shaping future nurses
– A basic intervention for behavioural crisis. Souvenir,
1st International Conference, Metamorphosis of nursing
education confronting current health needs – a time to
recuperate, Kasturba Gandhi Nursing College, Sri Balaji
Vidyapeeth Mahatma Gandhi Medical College & Research
Institute, Puducherry. 20-21 November 2013.
25.
Sekar K. (i) Psychosocial care for children in difficult
circumstances – Facilitator manual.
26.
Sekar K, Kavitha P, Joseph SJ, Kumar MS. Psychosocial
care for children in difficult circumstances – facilitator
manual. NIMHANS Bangalore.
27.
Sekar K. (i) (a) Life skills education for children in
difficult circumstances. (b) Student enrichment program.
(c) Enriching family life.
28.
Sekar K. Enriching psychosocial competencies among
children through NGOs in South India – Half yearly
report for the period April 2013 to September 2013.
29.
Sekar K. Kit material-Kit on student enrichment program.
30.
Shankar SK, Mahadevan A, Parmar SK. Histological atlas
of common infections of the nervous system with teaching
slides. Department of Neuropathology, NIMHANS,
Bangaluru, 28 March 2014.
31.
Thomas A, Gandhi S, Usha SN, Rajitha P, Mrudula G.
Nursing management of substance intoxication and
withdrawal. In: Gandhi S, Lalitha K, Ramachandra,
Prasanthi Nattala, Sivakumar T (eds). Psychiatric
emergencies and its management.
Monograph of
the workshop on psychiatric emergencies and its
management. Bangalore, NIMHANS, 2014; 57-62
5.
Laxmi TR. Decades of research in physiology and
pharmacology: reminders to remember and focus.
Souvenir Chapter. 59th Annual National conference of the
association of physiologists and pharmacologists of India.
28-30 November 2013 NIMHANS, Bangalore.
Valliammal S, Poornima HN. Manual on Immediate New
Born Care. NIMHANS College of Nursing Publications,
Bangalore, July 2013.
6.
Mrunal B, Ashok M. Does India need research in field
of post traumatic brain injury addiction? Indian J
Neurotrauma. 2013; 10: 139-140.
32.
Annual Report
7.
8.
9.
Nagarajaiah. Recent advances in somatoform disorders.
Souvenir. Annual National Conference of Indian Society
of psychiatric nurses. Westfort College of Nursing,
Thrissur, Kerala, March, 2013; 47-48.
Rathnamma. What it means to care? Times of India
(Bangalore edition), about Psychiatric rehabilitation
services, Page 5, 21 December 2013.
Sanjeev Jain, Pratima Murthy, Department of Psychiatry,
NIMHANS. Integrated approaches to understanding to
the brain and mind: a long tradition at NIMHANS. In
APPICON 2013 souvenir.
10.
Sivakumar T. Ethical and legal issues in emergency
psychiatry. Souvenir, Psychiatric emergencies and
its management. Department of nursing, NIMHANS
(Funded by Dr. Ramachandra N Moorthy Foundation for
Mental Health & Neurosciences).
11.
Sundar Periyavan (i) Utilization of Rh negative Groups
blood, Sankalp patrika, 2013; 3: 5 (ii) Can one donate
blood with diabetes, cholesterol, controlled blood
pressure and after cured tuberculosis? Sankalp patrika,
2013; 15.
F. ARTICLES FOR GENERAL PUBLIC/IEC
MATERIALS
2013-14
for the study of social exclusion and inclusive policy,
University of Mysore, 2013.
7.
Rajeswaran J, Sadana D. Week Magazine. Health
supplement. Room with a brilliant View. November 2013.
8.
Janardhanan CN. Crippling anxiety disorders on the rise.
The New Indian Express, 26 February 2014.
9.
Jayaram M. Article on stuttering in Vijaya Karnataka.
Public. October 2013.
10.
Sagar KJV. How to talk to children about rape- wall
street journal. (ii) Student suicides steadily rising in city,
Deccan Herald- 30 April 2013 (iii) Some can’t help it –
The Hindu,28 May 2013 (iv) Gadgets for kids: Yes or no?
Citizen Matters, 28 August 2013. (v) Raising a geniusBusiness Standard, 13 September 2013.(vi) The other
side of sexual abuse: More boys victims. The New Indian
Express, 12 October 2013. (vii) Special children too often
malnourished – The New Indian Express, 10 January
2014 (viii) Van driver nabbed for rape bid on Toddler –
Times of India, 10 January 2014. (ix) 2-year post-natal
leave for autistic kids’ mothers –Bangalore Mirror, 17
January 2014 (x) Social media abetting cyber bullying:
Doctors – DNA, 19 January 2014.
11.
Setty K. Interview Internet addiction (whats app), Vijaya
Karnataka, 9 February, 2014 (ii) Post partum disorders,
Vijaya Karnataka, 20 February, 2014 (iii) Interview
on sexual problems in couples, Vijaya Karnataka, 26
February, 2014.
1.
Chand P, Murthy P. Why and how I quit tobacco. World
No Tobacco Day, May 2013.
2.
Chandra PS. MOGGU Leaflets - Mental health of girls
growing up. Simple tips about handling emotions for
young women.
12.
Keshav Kumar J. Shaped by previous experiences. The
Choice is yours, Really? Health supplement. 4th Week
February.
3.
Chandra PS. A short film on handling emotions effectivelya film for young women from low income settings.
13.
4.
Chandra, PS, Satyanarayana V. Let the flower buds
blossom- stories on well being for young women. DHR
funded MOGGU Project
Manjula M, Singhal M, Herbert HS. An information
leaflet on dealing with academic stress (ii) An information
leaflet on Peer relationships: why do we need friendships,
NIMHANS Centre for Well Being, Bangalore.
14.
Manjula M. Social media changing relationships: Expert.
Deccan Herald, 7 November 2013.
15.
Mehrotra S, Micahel RJ, Elias JK. (i) Youth pro tool kit:
A compendium of activities and resource materials to be
used by youth pro volunteers for conducting mental health
promotion activities in the community. (ii) Motivational
video on youth engagement.
5.
6.
Girimaji SC. Contributed to the creation of resource
materials for parents and professionals for the website
devised by National Trust, Ministry of Social Justice and
Empowerment, Govt of india .
Gupta V, Rao GN. Public health in India: looking back to
move forward. New Public Health Issues in India. Centre
Annual Report
16.
17.
2013-14
Mehrotra S. (i) Scripts for street plays on issues related to
mental health for use in community programs, created by
youth pro members.(ii) A short video clip on community
engagement for persons with mental health issues created
by the ‘On Fire creative group’ of youth volunteers (as
part of youth pro activities).
Michael RJ, Banu H, Merotra S. Video clips on promoting
safe riding behaviors in youth.
18.
Mrunal B, Ashok M. Does India need research in field
of post traumatic brain injury addiction? Indian J
Neurotrauma. 2013; 10: 139-140.
19.
Nagarathna S. Hand hygiene and practices – Global Hand
Washing Day, 15 October 2013. (ii) Bangalore public
awareness programme and public education.
20.
21.
22.
NIMHANS Centre for Well Being (NCWB), in
coordination with the consultants who visited the centre
developed Information Education Communication
(IEC) leaflets in English on – Supporting our loved
ones: What works, Enabling resilience, Learning how
to relax, How to get good sleep, Effective parenting,
Enhance your study skills, Managing your anger,
Cell phone overuse and addiction, Dhat syndrome,
Somatoform Disorder, Bipolar affective disorder,
Social phobia, Panic disorder, Stress and coping,
NCWB services.
Padmavathy D. NCWB developed Information education
communication leaflets in Kannada on: Managing your
anger, Mental retardation, Harmful drinking and Alcohol
Addiction, Stress and coping, Marital Enrichment
services, How to get good sleep, Social phobia,
Somatoform disorder, Effective parenting, Cell phone
overuse and addiction, NCWB services.
Physiotherapy Section: Posters for general public &
visitors’ education purpose:Poster on core muscle
strengthening exercise and supportive pamphlets of
the same, coordination and balance exercises, gait and
pathological gait and supportive pamphlets, respiratory
management, Outcome measures booklet (scales reliability
and validity), Treatment videos and articles, biomechanics
of lumbar spine. Occupational therapy section: Poster
on introduction to Occupational therapy, occupational
therapy in geriatrics with physical deficits, occupational
therapy in geriatrics with cognitive deficits, for single
handed activities, ergonomics, therapeutic activities.
23.
Nattala P, Murthy P, Ramakrishna J, Rentala S. New
horizons: A short film on the journey of recovery after
quitting alcohol (Funded by a NIMHANS research grant
awarded to PrasanthiNattala).
24.
Murthy P. Tobacco Control.Press meet organised by
Institute of Public Health. Press. Print media. 6 June 2013
25.
Gandhi S. Prepared video assisted teaching module on
Specific psychiatric emergencies and their management,
which can be used as a teaching aid for nursing students,
newly recruited nurses and for caregivers of patients with
mental illness.
26.
Sekar K, Parthasaraty R, Kavitha P, Jospeh SJ. Student
enrichment program-flip chart. NIMHANS, Bangalore
(ii) Student enrichment program. Brochure in English,
Kannada, Tamil. NIMHANS Bangalore. 2013. (iii)
Enriching family life. Brochure in English, Kannada and
Tamil. NIMHANS, Bangalore. 2013.
27.
Shekhar S, Sowmya B, Arun V. The impatient ones,
Viewpoint October 2013.
28.
Shekhar S, Sowmya B. Enabling safety and freedom from
abuse within the school. Learning curve, December 2013.
29.
Shah A. Divorce rates in India. Indian Express, 19 July
2013.(ii) Women’s mental health. New Indian Express
section on Ten Commandments in Women’s Health, 25
January 2014.
30.
Shankar SK, Anita Mahadevan. Why Brain Banking?
Silver jubilee function of Healthy heart association.
31.
Rao BSS. Novel therapies to cure mental disorders are on
the anvil. The Hans India. 19 December 2013.
32.
Seshadri S, Ray A. (i) School bullying’ in newsletter of
Amnesty International – December 2013. (ii) Positive
mental health in children & adolescent’ Richmond
fellowship society India. 23 February 2014.
33.
Sivakumar T, Udgiri S, Chethan B, Devvarta K, Gandhi
S, Kumar CN, Nirmala BP, Bhola P, Desai G, Thirthalli
J, Chaturvedi SK. Welfare benefits for persons with
psychiatric disability (English, Kannada and Hindi
versions). Psychiatric Rehabilitation services, Department
of Psychiatry, NIMHANS, Bangalore. (Funded by Dr
Ramachandra N Moorthy Foundation for mental hesalth
& neurosciences).
Annual Report
34.
35.
Sivakumar T, Waghmare A, Chinnayya HP, Devvarta
K, Gandhi S, Kumar CN, Nirmala BP, Bhola P, Desai
G, Thirthalli J, Chaturvedi SK. (i) An information
leaflet on FAQ’s in Psychiatric rehabilitation (English,
Kannada and Hindi versions). (ii) Recovery oriented
services. Psychiatric Rehabilitation services, Department
of Psychiatry, NIMHANS, Bangalore. (Funded by Dr
Ramachandra N Moorthy Foundation for mental hesalth
& neurosciences).
9.
Sailaxmi Gandhi, Lalitha K, Ramachandra, Prasanthi
Nattala, Sivakumar T. Booklet, Psychiatric emergencies
and its management, funded by Dr. Ramachandra N
Moorthy Foundation for mental health and neurological
sciences.
10.
Setty VK, Shirlal S, Manasika kayilegalige vivida
chikitsegalu in Kannada, Private publisher, Bangalore, 2013.
11.
Shankaranarayana Rao BS, Sathyaprabha TN, Laxmi TR,
Kutty BM, Raju TR. Current physiological techniques:
from basic to applied aspects. NIMHANS, Bangalore,
2013.
12.
Sheela Kumari R, Tinu Varghese, Kesavadas C, Albert Singh
N, Mathuranath PS. A genetic algorithm optimized artificial
neural network for segmentation of MR Images in FTD.
Panigrahi BK et al. (Eds.): SEMCCO 2013, Part II, Lecture
Notes on computer sciences, 8298, Springer International
publishing Switzerland 2013; 268–276.
13.
Sheela Kumari, Tinu Varghese, Kesavadas C, Albert Singh
N, Mathuranath PS. Longitudinal evaluation of structural
changes in frontotemporal dementia using artificial neural
networks. In Satapathy SC, Udgata SK, Biswal BN (Eds.),
FICTA 2013, Advances in intelligent systems and computing,
247, Springer international publishing Switzerland 2014:
165-172.
14.
Subrath Mishra, Janardhana N, Saraswathy. Gender
perception of families and communities in community
mental health and development program (A BNI-NBJK
study report of Loherdaga District of Jharkhand and
Gaya District of Bihar). Gender and Mental Health, BNI
publication.
15.
Thomas PT, Rajaram P. MDA India. Psychosocial aspects
of DMD. In: Standard of care in Duchenne Muscular
Dystrophy. 2014 Available at URL: http://www.mdindia.
org/index.php
16.
Tinu Verghese, Sheela Kumari, Mathuranath PS, Albert
Singh. Performance evaluation of bacterial foraging
optimization algorithm for the early diagnosis and
tracking of Alzheimer’s disease. In Panigrahi BK et al.
(Eds.): SEMCCO 2012, Lecture notes in computer science
7677, Springer, Heidelberg 2012: 41-48.
Thomas PT. ‘Ankuttikalude Rogham’ (Malayalam) Article
on DMD Manorama Arogyam March 2014.
G. BOOKS PUBLISHED
1.
Andrade C. Critical readings in psychiatry, No. 7.
Ahmedabad: Zydus Neurosciences, 2013.
2.
Hamza A, Thirthalli J, Directory of mental health care
centers in south India. NIMHANS Publication, Bangalore,
2013.
3.
Jayanthi KN, Nagarajaiah. Booklet, Ethical and
legal guidelines for nursing practice, funded by Dr.
Ramachandra N Moorthy foundation for mental health
and neurological sciences.
4.
Jimmy Sebastian, Amir Hamsa M, Chandra SR. Effective
care giving in dementia – A learning module for caregivers.
5.
Kameshwar Prasad, Ravi Yadav. Bickerstaff’s neurological
examination in clinical practice. 7th adapted edition, Wiley
India Pvt. Ltd., New Delhi.
6.
Lalitha. Mental health and psychiatric nursing: New
Vision, Pub. By VMG Book House, Bangalore, 2013.
7.
Nirmala BP. (i) Rehabilitation hand book, Nirmala (Eds),
NIMHANS Publication, 2014. (ii) Handbook of Psychiatric
rehabilitation services. NIMHANS Publication, India, 2013.
8.
Prabha S. Chandra, Veena Satyanarayana. Let the flower
buds blossom: stories on wellbeing for young women.
NIMHANS Publication, Bangalore, 2014. (ii) Moggina
manassu aralali. Hadihareyada hennumakkalu
susthithiyalliralu kathegalu. NIMHANS Publication,
Bangalore, 2014.
2013-14
Photo Courtesy: Jasmin Maitreya
Annual Report
Contributions to
Scientific Deliberations
Meeting hosted by the society for Neuro Oncology, San
Francisco, California, USA,21-24 November 2013.
A. PRESENTATIONS IN INTERNATIONAL
CONFERENCES
1.
Abhishekh HA, Mehta UM, Thennarasu K, Thirthalli J.
Cortical excitability in schizophrenia: a meta-analysis of
transcranial magnetic stimulation studies. International
congress on schizophrenia research. Florida, USA. 21-25
April 2013.
2.
Alladi Phalguni Anand, Anita Mahadevan, Shankar SK,
Raju TR. Expression of synaptic proteins in normally
aging human substantia nigra pars compacta. 17th
International Congress of Parkinson’s Disease and
Movement Disorders. Sydney, Australia, 17-20 June
2013.
3.
4.
5.
6.
7.
Andrade C, Chethan KB, Surya S, Nagesh KS, Hegde
RP, Chandra JS. Stimulus variables as risk factors in
spinal fracture with ECT: Clues from an animal model.
Neuroscience CME, 6th Annual Chair Summit, Tampa, FL.
26-28 September 2013.
Anil R. (i) Muscle magnetic resonance imaging (MRI) in
patients with LGMD 2I confirm by immunohistochemistry
and/or immunoblotting. (ii) Magnetic resonance
imaging findings in immunohistochemically confirmed
sarcoglycanopathies. 21st World Congress of Neurology,
Vienna, Austria, 16-23 September 2013.
Anilkumar Sivan, Ravi Yadav, Pramod Kumar Pal. (i)
Comparison between early and late onset Parkinson’s
disease: a profile of 1000 patients from India. (ii) Impulse
control disorders in Parkinson’s disease: a case-control study.
20th World Congress on Parkinson’s Disease and Related
Disorders. Geneva, Switzerland, 8-11 December 2013.
Anisha Mary Abraham, Sudhir PM, Bantwal G. Barriers
to self-care, illness perceptions and their relationship
with self care, metabolic control and quality of life. 21st
European Congress of Psychiatry, Nice, France, 6-10
April 2013.
Arun Shastry, Sarwat Naz, Balaram Thota, Kandavel
Thennarasu, Arimappamagan Arivazhagan, Sampath
Somanna, Vani Santosh, Paturu Kondaiah. Therapy
resistance and survival in glioblastoma – the role of STAT1.World Federation of Neuro Oncology. 4th Quadrennial
2013-14
8.
Ashok M, Indira Devi B, Dhaval Shukla, Subbakrishna,
Neeraj U, Jamuna R. Quantitative evidence of brain
and its cognitive consequences: A longitudinal study. 31st
Annual National Neurotrauma Symposium, Nashville,
USA, August 2013.
9.
Ashok M, Jamuna R, Indira DB, Niranjana B, Neeraj
U. EEG Neurofeedback therapy: Can it attenuate
brain changes in TBI? 11th International Neurotrauma
symposium, Budapest, Hungary, March 2014.
10.
Ashwathnarayana DH, Madhusudana SN, Sudarshan MK,
et al. Assessing safety and immunogenicity of rabipur and
verorab. Results of randomized control trial using one
week intradermal regimen in post-exposure cases. Rabies
in Asia Conference, Bangkok, Thailand, 11-13 September
2013.
11.
Balachandar R, Tripati R, Bharath S, Sivakumar PT,
Kumar K, Loganathan S, Chandra SR, Varghese M.
Amnestic MCI beyond memory. 28th International
Conference of Alzheimer’s Disease International, 18-20
April 2013.
12.
Bharath RD, Panda R, Reddy RP, Upadhyay N, George
L, Thamodharan A, Rajeshwaran J, Rao SL, Gupta A.
Unraveling the brain resting state in the contexts of
gender, education and profession. American society of
Neuroradiology 2014 Annual Meeting, Florida.
13.
Bhaskar MV, Bharath RD, Gupta AK, Pal PK, Panda R,
Jhunjhunwala K. Assessment of brain plasticity induced
by rTMS in patient with writer cramp using resting state
connectivity. American society of Neuroradiology 2014
Annual Meeting, Florida.
14.
Bindu PS, Divyaraj R, Bharath RD. Central nervous system
inflammatory demyelinating disorders of childhood – a
clinical, magnetic resonance imaging and follow up study.
12th Asian & Oceanian Congress of Child Neurology 2013,
Saudi Arabia, 17 September 2013.
15.
Bindu PS, Shah MA, Mahadevan A, Gayathri N, Yasha
TC, Sinha S, Nagappa M, Bharath RD, Kumar A, Taly AB.
Annual Report
2013-14
PLA2G6 associated neurodegeneration: A phenotypic,
electrophysiological, radiological and histopathological
study from South India, Asian & Oceanian Congress of
Child Neurology, Saudi Arabia, 18 September 2013.
16.
Bücker J, Muralidharan K, Torres IJ, Su W, Kozicky J,
Silveira LE, Bond DJ, Honer WG, Kauer-Sant’anna M,
Lam RW, Yatham LN. Childhood maltreatment and
corpus callosum volume in recently diagnosed patients
with bipolar I disorder. 28th Annual Research Day, UBC,
Vancouver BC Canada, 6 June 2013.
17.
Chaitanya G. Effects of dexmedetomidine on
electrocorticography for temporal lobe surgeries. 30th
International Epilepsy Congress, International League
against Epilepsy, Montreal, Canada, June 2013.
18.
Chaitanya G, Sinha S, Reddy M, Arivazhagan A, Rao
MB, Thennarasu K, Chandramouli BA, Satishchandra
P. Dexmeditomedine anesthesia during intra-operative
electrocorticography recording: Promising, safe and
enhances spike generation. 30th IEC 2013, Montreal,
Canada, 27-30 June 2013.
19.
Chandrasekhar Sagar BK, Ravi P. Hegde, Chittaranjan
Andrade. Ultrastructural evidence reveals synaptic
modulation in the rat brain – A preliminary study.
The Annual Meeting of Nordic Microscopy Society,
Copenhagen, Denmark, 10-14 June 2013.
20.
Chaturvedi SK, Prasad Rao G. Chronic pain and
depression: an Indian experience, psychiatrica 7.0, A
Mental Health Academic Endeavor, Ho Chi Minh City,
Vietnam, 4-7 August 2013.
21.
Cherian AV, Dhanasekarapandian R, Suresh BM,
Thennarasu K, Reddy YCJ. (i) Does family accommodation
predict naturalistic outcome of obsessive compulsive
disorders? International Conference of the Anxiety
disorder association of America, San-Diego, USA, 4-7 April
2013. (ii) Clinical predictors of family accommodation
in obsessive compulsive disorders. 13th Forum on Mood
and Anxiety Disorders, Monte–Carlo, Moraco, 19-22
November 2013.
22.
Chetan GK, Sibin MK, Lavanya Ch, Jeru Manoj,
Dhananjaya Bhat. Exonwise deletion status of tumor
suppressor P16 gene in high grade glioma in the Indian
Population, ESHG, Paris, 8-11 June 2013.
23.
Christopher R. (i) Experience of tandem mass spectrometry
in India: feasibility and concerns. 8th Asia-Pacific Regional
Meeting of the International Society for Neonatal
Screening Conference, New Delhi, 28 September 2013
(ii) Newborn screening by tandem mass spectrometry,
Results of a pilot study. International meeting on New
Research and Advances in Prenatal Diagnosis and Fetal
Medicine. Centre for Human Genetics, Bangalore. 9
November 2013 (iii) Principles of mass spectrometry.
Pre-Conference Workshop, The Asia-Pacific Newborn
Screening Conference. Laboratory Techniques in Newborn
Screening, New Delhi, 26 September 2013.
24.
De T, Nagaraja D, Christopher R. (i) Pharmacogenetics
of acenocoumarol in patients with cerebral venous
thrombosis. Miami Winter Symposium 2014. The
Molecular Basis of Brain Disorders, Miami, USA, 2629 January 2014. (IBRO International Travel
Award). (ii) Influence of CYP2C9 polymorphisms on
acenocoumarol dose in patients with cerebral venous
thrombosis. Asia Pacific Stroke Conference- 2013, Hong
Kong, 1 September 2013.
25.
Dhiman V, Sinha S, Rawat VS, Harish T, Chaturvedi SK,
Satishchandra P. Outcome of adults with psychogenic
non-epileptic seizures and to propose a modified
semiological classification. 30th IEC 2013. Montreal,
Canada, 27-30 June 2013 (Best Poster Award)
26.
Divya Sadana, Jamuna Rajeswaran, Sanjeev Jain, Senthil
Kumaran. Unravelling creativity: an fMRI study. 9th
International Conference on Cognitive Science, Kuching,
Sarawak, Malaysia, 27 -30 August 2013.
27.
Gautham MS, Kowshik Kupatira, Gururaj G. Feasibility
of integration of mental health screening in annual
medical examination of employees in a motor industry.
International Conclave of Occupational Health and 64th
Annual Conference of Indian Association of Occupational
Health. Panaji, Goa, 10-14 February 2014.
28.
Gope R. Post translational modifications of proteins
and their importance in drug development with special
reference to human intracranial tumors. Genomics
and Proteomics Research, organized by SELECTBIO.
Sheraton, Bangalore. 27-28 September, 2013.
29.
Gorky Medhi, Dutta HK. Sincipital Encephalocele: A Case
Series. 99th Scientific Assembly and Annual Meeting of
Annual Report
Radiological Society of North America 2013, McCormick
Place, Chicago. 1-6 December 2013.
30.
31.
32.
33.
34.
Gowda G, Kumar CN, Math SB. Patient perceptions of
coercion in mental hospital admission: an exploratory
study. 2nd Indo-European Symposium on Coercion,
Mysore Medical College and Research Institute, Mysore,
24-25 March 2014.
Gupta HK. Exploration of psychological distress among
care givers in ayurvedic treatment setting. Annual
National Conference of Indian Psychiatric Society, Pune,
16- 19 January 2014.
Guruprasad D, Bhola, P. Autobiographical memory
narratives of clients with borderline personality disorder
in psychotherapy. Society for Psychotherapy Research
UK Conference. Oxford, UK. 12-14 September 2013.
Gururaj G (i) Case studies on improving road safety in
India. International Injury Research Unit, Johns Hopkins
University, Baltimore, USA, 12 April 2013 (ii) Challenges
and barriers for implementing drink drive legislation and
enforcement: A case study from Bangalore. International
Council on Alcohol, Drugs and Traffic Safety. Brisbane,
Australia, 23-28 August 2013 (iii) Deaths due to drowning
in India: need for prevention policies and programmes.
World Congress of Drowning Prevention, Potsdam,
Germany, 20-23 October 2013 (iv) Rehabilitation needs
of acquired brain injury survivors: results from the
traumatic brain injury registry in Bangalore. 10th World
Congress of Brain Injury, San Francisco, USA, 19-22
March 2014 (v) (a) Road Traffic injury is a public health
problem (b) Road safety information systems in low and
middle income countries. (c) International Road Safety
Course, Effectiveness of seat belts (d) Challenges in
implementing drink drive laws in low and middle income
countries. Delft University. Delft, Netherlands, 16-22
September 2013.
Harish G, Mahadevan A, Srinivas Bharath MM, Shankar
SK. Alteration in glutathione content and associated
enzyme activities in the synaptic terminals but not in
the non-synaptic mitochondria from the frontal cortex
of Parkinson’s disease brains. 20th World Congress on
Parkinson’s disease and Related disorders, Geneva,
Switzerland, 8-11 December 2013.
2013-14
35.
Hazra N, Mani R, Desai A, Sinha S, Netra M, Taly AB,
Satishchandra P, Ravi V. SSPE and HIV: Two rare case
reports. 2nd International symposium on Infectious
diseases, HIV SCIENCE 2014, conducted by YRG Care,
Chennai, 30 January - 01 February 2014.
36.
Hazra N, Sinha S, Madhusudana SN, Ravi V. Childhood
and adult onset SSPE: Tale of two clinical perspectives.
VIROCON 2013, AMITY International, Noida Campus 1720 December 2013.
37.
Hirisave U. Attachment issues child perspective. 7th
Congress of Asian Society for Child and Adolescent
Psychiatry & Allied Professions and 12th Biennial
Conference of Indian Association for Child and Adolescent
Mental Health, New Delhi, 27 September 2013.
38.
Jacob P, Kandasamy P, Seshadri SP. Practical management
of child sexual abuse in the Indian setting. 7th Congress
of Asian Society for Child and Adolescent Psychiatry and
Allied Professions, New Delhi, 25-28 September 2013.
39.
Jagath Lal G. Endoscopic surgery for suprasellar
arachnoid cyst – the lesions learned. 6th World Congress
of Neuroendoscopy, Mumbai, 8-10 December 2013.
40.
Janardhan Reddy (i) Antidepressants in bipolar
disorder. CME by the Psychiatric Association of Nepal,
Kathamnadu, Nepal 2013 (ii) Poor insight in OCD and its
clinical correlates. Mood Disorders Meeting organized by
the Lundbeck Pte Ltd, Seoul, South Korea. March 2014.
41.
Janardhana N. Mental health care with the
institutionalized children. International seminar for the
SARC countries, Udayan Care, 15-16 March 2014.
42.
Jeetendra Kumar Singal, Jamuna Rajeswaran,
Harikrishna Maiya, Divya Sadana, Hariom Sharma.
Brain electrophysiological correlates of creativity. 9th
International Conference on Cognitive Science, Kuching,
Sarawak, Malaysia, 27-30 August 2013.
43.
Jha M, Pal PK, Saini J, Kumar K J, Yadav R, Bagepally
B. Cognitive profile in patients with Parkinson’s disease
with and without freezing of gait and correlation with
neuroimaging. 21st Annual Conference of Indian Academy
of Neurology. Indore, 24-27 October 2013 (Awarded 1st
Prize in Platform Award Paper Presentation)
Annual Report
44.
2013-14
Joshi S, Rynjah IL, Bhutani R, Paul I, Bada Math
S, Shah A. Family therapy in a case of transgender.
International Conference on Family at Cross Roads: 21st
century, Bombay Psychological Association, Mumbai, 1-3
December 2013.
45.
Joy SP, Sinha S, Pal PK, Panda S, Philip M, Taly AB.
Quality of sleep in drug naive patients with early
Parkinson’s disease and effect of dopaminergic treatment:
A prospective study. 17th International Congress of
Parkinson’s Disease & Movement Disorders, Sydney,
Australia, 16-20 June 2013.
46.
Joy SP, Sinha S, Pal PK, Panda S, Philip M, Taly AB.
Polysomnographic study of sleep macrostructure in drug
naïve Parkinson’s disease patients with follow up after
starting levodopa treatment. SLEEP 2013, Baltimore,
USA, 1 -5 June 2013.
47.
Kandasamy A, Aneel R, Prabu J, Poornima S, Chand P,
Benegal V, Murthy P. A study on substance use disorders
in physicians. Young Asian Psychiatrist Meet, Bangkok.
YAP-2013.
48.
Ketaki Bhalsing, Ravi Yadav, Jitender Saini, Keshav
Kumar, Arun Kumar Gupta, Pramod Kumar Pal, Neeraj
Upadhyay. Lateralization of structural abnormalities
in right cerebellum in essential tremor: an observation
from voxel based morphometry study. 17th International
Congress of Parkinson’s Disease and Movement
Disorders, Sydney, Australia. 16-20 June 2013.
49.
Ketan J, Netravathi M, Pal PK. Post-infectious MD, WFN2013, Vienna, Austria, September 2013.
50.
Ketan Jhunjhunwala, Netravathi M, Saini J, Pal PK. A
clinical and imaging profile of 35 patients with movement
disorders associated with infection. 21st World Congress
of Neurology, Vienna, Austria, 21-26 September 2013.
51.
52.
Ketan Jhunjhunwala, Prashanth DK, Pramod Kumar
Pal. Alterations of cortical excitability and central motor
conduction time in patients with Wilson’s disease. 17th
International Congress in Movement disorders in Sydney,
Australia.
Kumar CN. (i) (a) Experience of treating severe mental
disorders in the rural communities. (b) Alcohol use in
patients with schizophrenia: comparison with that of
general population. Building a Collaborative Platform
and Professional Training Workshops for Community
Mental Health in Developing Countries, Taipei, Taiwan,
28 October - 4 November 2013.
53.
Lalitha K. (i) Cognitive rehabilitation and memory
enhancement for elderly. International Conference on
Active Ageing - PSG College of Nursing, Coimbatore, 22
January 2014 (ii) Sampling techniques. International
Conference on Quantitative Approaches in Nursing
Research, Dayananda Sagar College of Nursing, Bangalore,
27 September 2013 (iii) Value based education in shaping
future nurse – A basic intervention for behavioural crisis.
1st International Conference. Theme: Metamorphosis
of nursing education and practice confronting current
health care needs – A time to recuperate, Kasturba
Gandhi Nursing College, Puducherry, 20 November
2013 (iv) Collaboration between theory and practice.
International Conference, Group Dynamics, Krishna
Institute of Nursing Sciences, Nellore, Andhra Pradesh.
26 July 2013 (v) Trends in nursing research for advanced
nursing practice – a global challenge. First International
Conference, Epidemiological Research for Advanced
Nursing Practice – A Global Health Scenario, College
of Nursing, Pondicherry Institute of Medical Sciences,
Pondicherry, 27 July 2013.
54.
Laxmi TR, Dayalan Sampath, Preethi Hegde, Sabitha
Nair. Maternal deprivation affects information processing
in sleep. Gordon research conference on amygdala in
health and disease, Stonehill College, Easton, MA, USA.
28 July-2 August 2013.
55.
Madhusudana SN, Manjunatha MV, Reeta Mani. Dual
role of immune response in rabies encephalitis. Studies in
murine model and its implications in humans. Rabies in
Asia Conference, Bangkok, Thailand, 11-13 September 2013.
56.
Madhusudana SN. Immunopathogenesis of rabies: New
insights. 3rd International World Congress of Virology,
Baltimore, USA, 22-24 November 2013.
57.
Mahadevan A, Maya Bhat, Satishchandra P,
Madhusudana SN, Shankar SK. Neuropathological
correlation of neuroimaging features in rabies. Rabies
in Asia Conference 2013, Bangkok, Thailand, 11-13
September 2013.
58.
Malla Bhaskara Rao. NIMHANS Epilepsy Surgery
Programme. King’s College Hospital and Institute of
Neurology, London, UK, 11-13 March 2014.
Annual Report
59.
Malvika R, Desai G, Chandra PS, Thippeswamy H. Course
and outcome of bipolar disorder during pregnancy- a
report from perinatal psychiatry clinic in India. Perinatal
Mental Health Conference, Chicago, Illinois, USA. 6-8
November 2013.
60.
Manjunath M, Nalini A, Christopher R. Fatty acid
oxidation disorders presenting as primary myopathy
and identified by tandem mass spectrometry. 14th Asian
and Oceanian Congress of Neurology, Macao, China, 2-5
March 2014.
61.
Manjunath M. Tipin cap polymorphisms (TCAP)
associated with LGMD 2G among Indian patients with
ARLGMD. (ii) Fatty acid oxidation disorder presents
as primary myopathy & identified by tandem mass
spectroscopy. Asian Oceanic Congress of Neurology
(AOCN) 2014, Macao, China, 2- 5 March 2014.
62.
63.
64.
65.
66.
67.
Manjunatha MV, Nandita Hazra, Shaheen Taj, Sampada
Sanyal, Ashwin Belludi, Reeta Mani, Madhusudhana SN.
Th1 and Th2 CD4 T cell responses to rabies vaccination –
A preliminary study. Rabies in Asia Conference, Bangkok,
Thailand, 11-13 September 2013.
Marimuthu P. Challenges in determining threshold
value/s from a battery of psychological tests for the
diagnosis of dementia. A joint conference of International
Symposium on the Evaluation of Clinical Trials and the
International Biometric Society – East Asia Regional
Biometric Conference, Renmin University of China,
Beijing, 5-7 July 2013.
Megha Rupa. Attachment in the context of parenting.
7th Congress of Asian Society for Child and Adolescent
Psychiatry and Allied Professions and 12th Biennial
Conference of Indian Association for Child and Adolescent
Mental Health, New Delhi, 25-28 September 2013.
Muralidharan K, Silveira LE, Kozicky JM, Bucker J,
Fernando N, Torres IJ, Yatham LM. Do mood stabilizers
affect cognition in early bipolar I disorder? Data from
the STOP-EM study. 28th Annual Research Day, UBC,
Muralidharan K. Practice guidelines for ECT across the
world: a comparison. ECT symposium 2013, Bangalore,
7 December 2013.
Mythili D. Effectiveness of concept mapping in improving
nursing student knowledge and attitude related to care of
2013-14
HIV & AIDS patients. NIMRCPPSYCON Conference on
Training and Learning for the 21st Century Trainers in
Psychiatry, 7-8 March 2014.
68.
Nandakumar DN, K Hurmath Fathima, R Palaniswamy.
Interleukin-1β micro-environment promotes viability
and proliferation of malignant glioma cell U87MG. 15th
International Congress of Immunology-ICI, Milan, Italy,
22-27 August 2013. (International Travel Award by
ICMR and DBT).
69.
Narasinga Rao KVL. Correlation of angiographic anatomy
with intraoperative microsurgical anatomy – Lessons learnt.
NEUROVASCON Conference, 21-23 September 2013.
70.
Narayanaswamy JC, Anandan S, Rakesh G, Shivakumar V,
Joseph B, Kalmady S, Agarwal SM, Venkatasubramanian
G. A study of emotion processing strategies in bipolar
disorder: novel evidence for the endophenotype status
of labeling deficit. International Conference on Bipolar
Disorder (ICBD), Miami, USA, June 2013 (Won the
Samuel Gershon Award).
71.
Nayak C, Nagappa M, Nagaraj K, Kulkarni GB, Kandavel
T, Sinha S, Taly AB. Study of sleep microstructure in
patients of migraine without aura. ICCN 2014, Berlin,
Germany, 20- 23 March 2013.
72.
Netravathi M. Post-traumatic movement disorders,
correlation of clinical phenomenology with radiological
and electrophysiological characteristics, AOCN 2014,
Macao, China, 2- 5 March 2014. (Second Prize – Best
Paper Award)
73.
Padmavathy D, Ragesh G. A brief skill-based gatekeeper
training program for suicide prevention, NIMRCPSYCON
2014, Second Joint Conference of the Department
of Psychiatry NIMHANS, and the Royal College of
Psychiatrists, UK, 7-8 March 2014.
74.
Panda R, Bharath RD, Reddy RP, Upadhyay N,
Thamodharan A, Kanungo S, Rao SL, Gupta A. Brain
functional connectivity of learning memory: an fMRI
study. American society of Neuroradiology 2014 Annual
Meeting, Florida.
75.
Panda R, Bharath RD, Sandhya M, Upadhyay N, Kanungo
S, Thamodharan A, Rao SL, Gupta A. Effect of rajyoga
meditation: a resting state simultaneous EEG-fMRI
Study. American society of Neuroradiology, Annual
Meeting, Florida.
Annual Report
76.
77.
2013-14
Prabha S Chandra. (i) Challenges in management of
somatisation in Psychiatry Practice. Ho Chi Minh City,
Vietnam, 5-6 August 2013 (ii) Use of psychotropics in
cancer care. International Psycho-Oncology Society
Academy on Psycho-Oncology. Tata Memorial Cancer
Hospital and Research Centre, 29 November - 1 December
2013 (iii) Singing lullabies inside the bell jar- motherhood
and mental illness, Indo Canadian Psychiatric Association.
Annual Meeting of the Canadian Psychiatric Society,
Ottawa, 27 September 2013.
Pramod Kumar Pal (i) Neuropsychological and imaging
profile of patients with Parkinson’s disease and freezing
of gait. 20th World Congress on Parkinson’s disease and
Related Disorders, Geneva, Switzerland, 8-11 December
2013 (ii) Treatment of autonomic disturbances in
Parkinson’s disease. 21st World Congress of Neurology.
78.
Pratibha S, Anilkumar Sivan, Ravi Yadav, Pramod Kumar
Pal. Treatment profile of 1000 patients with Parkinson’s
disease at the time of referral to a tertiary care centre in
India. 20th World Congress on Parkinson’s disease and
Related Disorders, Geneva, Switzerland, 8-11 December
2014.
79.
Pratima Murthy (i) Challenges for tobacco cessation in
India. International Conference International Medical
Sciences, Academy (Karnataka State branch), Royal College
of Physicians and Surgeons, Glasgow, UK, 5 October
2013 (ii) Increasing effectiveness of tobacco cessation,
International Conference on End Game for Tobacco, Hriday
Shan, 11 September 2013, New Delhi (iii) Substance abuse
in children and adolescents: current trends. 7th Congress of
the Asian Society for Child and Adolescent Psychiatry and
Allied Professions and 12th Biennial Conference of the Indian
Association for Child and Adolescent Mental Health, New
Delhi. 27 September 2013.
80.
Rajakumari K, Jamuna Rajeswaran, Neeraj Upadhyay,
Silpa Kanungo. Perspective taking and emotional
contagion: glass brain view of empathy. 9th International
Conference on Cognitive Science, 27 - 30 August 2013,
Kuching, Sarawak, Malaysia.
81.
Rajalakshmi R. Psychosocial care needs of parents having
children with epilepsy. International Conference on
Convergence of Science, Engineering and Management
in Education and Research – Global Perspectives. 26-27
September 2013.
82.
Rajeswaran J. (i) Creativity and Cognition. First
International Conference on Neuro-Management Indian
Institute on Management Ranchi, 9-11 December 2013
(ii) Working memory and creativity – EEG Study, 9th
International Conference. Kuching, Sarawak, Malaysia,
27-30 August 2013.
83.
Raju TR. Neurodegeneration-Amyotrophic lateral
sclerosis – does CSF hold clues? International Conference
on Adult Neurogenesis: From Stem Cells to Therapies.
Tata Institute of Fundamental Research, Mumbai, 6-8
February 2014.
84.
Ravi V. (i) A century of rise and fall of human viral
infections- Asia Pacific Congress of Virology, VIROCON
2013, Amity University, New Delhi, 16-20 December 2013
(ii) Opportunities for research at NIMHANS. Launch
of the Welcome Trust Scientific Alliance of University
of Glasgow - University of Liverpool-NIMHANSEucador and Malawi, Glasgow, UK. 6 December 2013
(iii) Overview of basic sciences research at NIMHANS.
Annual Welcome Trust Scientific meeting of University
of Liverpool-NIMHANS and Malawi, Liverpool UK.
3-7 September 2013 (iv) Viral encephalitis - An update.
Annual Conference of the Sri Lanka College of Medical
Microbiologists, Colombo, Sri Lanka, 22-26 July 2013.
(Keynote address) (v) Viral diagnostics in India-Where
do we stand. International Conference on Innovations in
Biotech and Medicine, Bangalore Medical College, 21-23
October 2013.
85.
Ravikumar R, Jyothi EK. Present status of laboratory
diagnosis of neurotuberculosis in a developing country:
a perspective from a tertiary neurocare hospital,
Bangalore, South India. 53rd Interscience Conference
on Antimicrobial Agents and Chemotherapy, American
Society of Microbiology, Denver, Colorado, USA, 10-13
September 2013.
86.
Ravindra Thakkar, Chandrasekhar Sagar BK, Hemavathy U,
Ramesh G, Yasha TC, Gayathri N, Bindu PS. Epidermolysis
Bullosa – A diagnostic approach by Ultrastructural studies,
International Conference on Electron Microscopy and 34th
Annual meeting of the Electron Microscope Society of
India, Kolkata, 3-5 July 2013.
87.
Ravish HS, Sudarshan MK, Madhusudana SN et al.
Interchangeability of route and type/brand of rabies
vaccines in post-exposure prophylaxis. Safety and
immunogenicity studies. Rabies in Asia Conference
Annual Report
Congress on Parkinson’s Disease and Related Disorders,
Geneva, Switzerland, 8-11 December 2013.
(RIACON 2013), Bangkok, Thailand, 11-13 September
2013.
88.
89.
90.
Reddi VSK. (i) Facilitating mutual learning and
professional training on mental health issues. Building
the Collaborative Research Platform and Professional
Training Workshop for Community Mental Health in
Southeast Asia, Taipei medical university Taipei, Taiwan,
29 October 2013. (ii) Liaison mental health services at
NIMHANS, Taipei City Hospital, Songde Branch, Taipei,
Taiwan, 31 October 2013.
Reeta Mani, Ashwin YB, Madhusudana SN. Genetic
characterization and assessment of purity of commercial
human rabies vaccines available in India. Rabies in Asia
Conference, Bangkok, Thailand, 11 -13 September 2013.
Roopa R, Nagarchi Khaleel, Chandrasekar Sagar BK,
Bindu M Kutty, Andrade C. Increased electroconvulsive
shock dosing causes favourable neuroplastic shift in
basolateral amygdala neurons even in normal rats.
Amygdala in Health and Disease, Gordon Research
Conferences, Easton, MA, USA, 28 August- 2 September
2013.
91.
Roopesh BN, Siddharth, D, Prateeksha S, Sneha TS,
Vijaysagar J. Just world belief of parents of children with
conduct disorder. International Conference of Bombay
Psychological Association, Mumbai, 1-3 December 2013.
92.
Sadanand S, Kota LN, Bagepally BS, Shivakumar P,
Balachander R, Loganathan S, Sivakumar PT, Bharath S,
Varghese M. Cognitive test performance in persons with
dementia in India. 16th Asia Pacific Regional Conference
of Alzheimer Disease International, Hong Kong, 11-13
December 2013.
93.
94.
Sailesh Modi, Atchayaram Nalini, Narayanappa
Gayathri, Srinivas Bharath MM, Balaraju Sunitha, Kiran
Polavarapu. (i) (a) Detection of limb girdle muscular
dystrophy 2A (Calpainopathy) by Autocatalytic activity
of Calpain and by quantification of Calpain bands by
Densitometry (b) LGMD2I: immunohistochemical and
immunoblot technique assisted identification of 51 cases
with both Duchenne and Becker phenotype. World
Congress of Neurology, Vienna, October 2013.
Saini J, Jhavar K, Pal PK, Yadav R, Bagepally B. Subcortical
gray matter abnormalities in patients of essential tremor
revealed by MR volumetry and vertex analysis. 20th World
2013-14
95.
Saini J, Yadav R, Bhalsing K, Pal PK. Subcortical structural
abnormalities in essential tremor: MR volumetry and
vertex based analysis. 20th World Congress on Parkinson’s
disease and Related Disorders, Geneva, Switzerland, 8-11
December 2013.
96.
Sathyaprabha TN, Ravikiran Kisan, Raghavendra Rao,
Sujan, Nalini A, Raju TR. Immunological modulation by
yoga therapy in migraine patients. 16th Congress of the
International Headache Society, Boston, Massachusetts,
USA, 27-30 June 2013.
97.
Satishchandra P (i) What is good enough neurology for
psychiatry trainees. 2nd Joint Conference – NIMRCPCON
2014, Bangalore, 7 March 2014 (ii) Vasculitis and stroke
in CNS Tuberculosis. 21st World Congress of Neurology.
98.
Sekar K (i) Mental health and social work. International
Social Work Conference 2014 Interdisciplinary
Intervention and Cross Cultural Sharing in Social Work.
Madras School of Social Work, Chennai. 8 February 2014
(ii) Social work professional associations and its role in
India. International Conference on Realising Rights,
Duties, Citizenship through Social Policy and Professional
Social Work Practice. IRSES, European Union Seventh
Framework Programme, Marie Curie, Loyola College,
Chennai, 11 January 2014.
99.
Shankaranarayana Rao BS, Veena J, Srikumar BN,
Bhagya V, Mahati K, Raju TR. Activation of hippocampal
neurogenesis ameliorates chronic stress-induced cognitive
deficits and depressive-like behaviour in adult rats.
International Conference on Adult Neurogenesis: From
stem cells to therapies. Tata Institute of Fundamental
Research, Mumbai, 6-8 February 2014.
100. Shankaranarayana Rao BS. (i) (a) Glia and neural
plasticity: Implications for the treatment of neurological
and psychiatric disorders. APSN-ISN Neuroscience
School on Glia in Neuronal Health and Disease, 2730 January 2014 (b) Presenilins and aging brain:
Molecular mechanisms underlying age-dependent
neurodegeneration, memory loss and impaired synaptic
plasticity. International conference on Neurochemistry of
Ageing Brain CSIR-Indian Institute of Chemical Biology,
Kolkata. 31 January - 1 February 2014 (ii) Innovative
Annual Report
2013-14
therapeutic strategies to treat depression. International
Conference on Neurosciences: Brain Plasticity and
Neurological Disorders, Revenshaw University, Cuttack,
9-11 November 2013 (iii) National and International
higher education and career opportunities in Medical
biotechnology. Proceedings of International workshop
on Higher education and career opportunities in
Biotechnology during First International and Third
National Conference of Biotechnology, Bioinformatics and
Bioengineering, Tirupati, 29 June 2013 (iv) Recent trends
in neuroscience research and funding opportunities.
IBRO-APRC Associate School of Neuroscience on
Emerging Trends in Neuroscience: Molecular and Cellular
Approches. Banaras Hindu University, Varanasi, 19-23
October 2013 (v) Rescue of symptoms of fragile X mental
retardation syndrome in mice: Implications for treating
autism and autism spectrum disorders. Proceedings
of 1st International and 3rd National Conference of
Biotechnology, Bioinformatics and Bioengineering.
Tirupati, 28-29 June 2013 (vi) Restoration of hippocampal
synaptic plasticity and cognitive functions in stress and
depression. International symposium on Hippocampus:
From Synapses to Behavior. Indian Institute of Science
Education and Research, Pune, 1-3 December 2013 (vii)
The ever changing brain: New challenges in treating
brain disorders. IBRO-APRC Associate School of
Neuroscience on Emerging Trends in Neuroscience:
Molecular and Cellular Approaches. Banaras Hindu
University, Varanasi, 19-23 October 2013 (viii) Innovative
therapeutic strategies to treat depression. International
Conference on Neurosciences: Brain Plasticity and
Neurological Disorders, Ravenshaw University, Cuttack,
India, 9-11 November 2013 (ix) Neural plasticity and
repair of abnormal brain circuits: Challenges in treating
neurological and psychiatric disorders. 5th Congress of
Federation of Indian Physiological Societies (FIPS) on
Physiology, Ethnopharmacology, Biotechnology and
Health Therapeutics, Sri Venkateshwara University,
Tirupati, 17-19 December 2013.
101. Sharma MK, Chaturvedi SK. Prevalence of pain and
treatment seeking behavior in the community. Maxa Tria,
Singapore Expo, Singapore, 2-5 May 2013.
102. Sharma R, Harsha HC, Prasad KTS, Pandey A, Nagaraja
D, Christopher R. Proteins with altered levels in serum
from acute ischemic and hemorrhagic stroke patients
as revealed by iTRAQ-based differential proteomic
analysis, Gordon Research Conference: Post translational
Modification Networks, The Hong Kong University of
Science and Technology, Hong Kong, SAR, China, 28
July-2 August 2013.
103. Shastry AH, Reshma Narayan, Balaram Thota, Sampath
Somanna, Kandavel Thennarasu, Arimappamagan
Arivazhagan, Vani Santosh. Expression patterns of
insulin-like Growth Factor Binding Protein (IGFBP)
isoforms in medulloblastoma subtypes and clinical
correlation. 4th Quadrennial Meeting of the World
Federation of Neuro-Oncology, San Francisco, California,
USA, November 2013.
104. Shilpa BM, Mahati K, Bhagya V, Raju TR,
Shankaranarayana Rao BS. (i) Enriched environment
ameliorates stress-induced spatial learning deficits and
depressive behavior without anxiety and amygdalar
hypertrophy. (a) 12th Annual Molecular and Cellular
Cognition Society Meeting, San Diego, USA, 7-8
November 2013 (b) 43rd Annual meeting of the Society
for Neuroscience Conference, San Diego, USA, 9-13,
November 2013.
105. Shivashankar N. Central auditory processing disorders
in neurological population with special reference to
MMND, 3rd Ventricular Tumor and TLE. 2nd Global CAPD
Conference, Orlando, Florida, USA, 28-29 March 2014.
106. Shukla D, Chandramouli BA, Sastry KVR, Das BS.
Sampath S. Does intraoperative rupture affect outcome
of aneurysm surgery? World Congress of WFNS, Seoul,
South Korea, 2013.
107. Silveira LE, Bond DJ, Torres IJ, Muralidharan K, Lam
RW, Kozicky JM, Bucker J, Yatham LN. Neurocognitive
function in overweight/obese patients with Bipolar
Disorder: data from the systematic treatment optimization
program for early mania. 28th Annual Research Day, UBC,
108. Sinha S, Velmurugan J, Nagappa M, Taly AB,
Satishchandra P. Localization and propagation of
physiological sleep vertex transients with EEG & MEG
using realistic head model. 30th International Congress of
Clinical Neurophysiology, Berlin, Germany, 20- 23 March
2013.
109. Sowmyashree Mayur Kaku. Magnetic resonance
spectroscopy – review and future trends in autism
spectrum disorder. International Conference on
Developmental Disabilities, Kolkata, 6-8 March 2014.
Annual Report
110. Sowmyashree Mayur Kaku, John Vijay Sagar, Shekhar
Seshadri, Satish Chandra Girimaji, Shoba Srinath.
Pervasive refusal syndrome – a nosological puzzle.World
Psychiatric Association International Congress 2013,
Vienna, Austria, 27-30 October 2013.
111. Srinath S, Jairam R, Kandasamy P. Affective disorders
in children and adolescents: Current status and
controversies. 7th Congress of the Asian Society for Child
and Adolescent Psychiatry and Allied Professions, 25-28
September 2013.
112. Subasree R. Education program teaching course/
Workshop, Nerve and Muscle Ultrasound. WFN 2013,
Vienna, Austria, September 2013.
113. Sudhakar D. Training programme. Organized by
Department of Science and Technology, Govt. of India,
New Delhi, Australia, 14-18 October 2013.
114. Taksal A, Sudhir PM, Keshav Kumar J, Jagadish,
Deepashree. Does the Integrated psychological therapy
improve neurocognition and social-functioning in
patients with schizophrenia? ECSR Congress, Berlin,
Germany, 26-28 September 2013.
115. Thirthalli J, Abhishekh HA, Kumar CN, Gangadhar
BN. A novel method of altering stimulus parameters to
induce seizures during electroconvulsive therapy. ECT
Symposium, NIMHANS, Bangalore, 7 December 2013.
116. Thomas PT, Rajaram P, Nalini A. Psychosocial
challenges in family care giving in duchenne
muscular dystrophy. Myocon 2014 – International
Conference on Neuromuscular Disorders, Chennai,
10-12 January 2014.
117. Thomas PT, Rajaram P, Chandra S. Supportive
psychotherapeutic intervention in Dementia. Gerontology
– A social work perspective. One day International
Conference conducted in School of Social Work, Roshni
Nilaya, Mangalore.
118. Urvakhsh
M,
Waghmare
A,
Thirthalli
J,
Venkatasubramanian G, Gangadhar B. Enhancing
putative mirror neuron activity: a novel therapeutic
application of repetitive transcranial magnetic stimulation
(rTMS). 11th World Congress of Society for Brain Mapping
and Therapeutics, Sydney, Australia, 17-19 March 2014.
2013-14
119. Vani Santosh. Conducted teaching sessions and delivered
the following guest lecturers (a) Slide Session - Infections
of CNS and Meningioma (b) Pathology of Meningeal
Tumors (c) Update on pediatric and embroynal tumors
(d) Slide sessions - tumors of the CNS (e) Molecular
diagnosis in central nervous system tumors (f) Discussion
on -Interesting cases in Neuropathology (g) Pathology of
muscular dystrophies (h) Slide session-Neuromuscular
disorders. Symposium-Neuropathology, Kuwait Institute
for Medical Specialization, Kuwait, 23-26 September 2013.
120. Varghese M, Roy J. Making Dementia a public health
priority – impact of the Dementia India report. The
National Dementia Strategy Group of ARDSI. 28th
International Conference of the Alzheimer’s disease, ADI
2013, Taipei, 18-20 April 2013.
121. Veerendrakumar Mustare (i) Serial single fibre EMG
studies in myasthenia gravis. 30th International Congress
of Clinical Neurophysiology 2013, Berlin, 20-23 March
2014 (ii) Normal single fibre electromyography of facial
muscles in ocular /mild generalised myasthenia gravis.
5th Asia-Oceanian Congress of Clinical Neurophysiology
2013. Bali, Indonesia. 28-31 August 2013.
122. Velmurugan J, Sinha S, Nagappa M, Mariyappa N,
Prasanth G, Bindu PS, Hazra N, Ravi V, Taly AB,
Satishchandra P. Source localization and propagation
of periodic complexes in subacute sclerosing pan
encephalitis using MEG-EEG: A Novel approach towards
understanding subcortical myoclonus. 30th International
Congress of Clinical Neurophysiology 2014, Berlin,
Germany, 20-23 March 2013.
123. Vijay K Kalia, Kalyani Kumari, Sai Shyam, Jennifer George,
Chandrasekhar Sagar BK, Jagath Lal. Preclinical studies
for increasing radiation response of malignant brain
tumour. Proceedings of the International Conference on
Radiation Biology and Clinical Applications Indian Society
for Radiation Biology, Nitte University, Mangalore, 25-27
October 2013.
124. Vijay Kumar Kalia. Approaches for improving cancer
radiotherapy. Proceedings of the International Workshop
on Strategies in Radiation Research, KS Hegde Medical
Academy, Nitte University, Mangalore, October 25, 2013.
125. Vivek Benegal. (i) (a) Neurobiology of vulnerability to
addiction. Symposium on Substance Abuse in Children
Annual Report
2013-14
and Adolescents: Current Trends. (Keynote address)
(b) Course on management of substance abuse in children
and adolescents. 7th Congress of Asian Society for Child
and Adolescent Psychiatry and Allied Professions and
12th National Biennial Conference of Indian Association
for Child and Adolescent Mental Health. New Delhi
September 2013 (ii) Treatment of alcohol dependence.
CME, Alcohol (a) organized by the Sri Lanka college
of psychiatrists. Ahungalla, Sri Lanka, October, 2013
(Keynote address) (b) Synapse Symposium. Nepal
Psychiatric Society, Kathmandu, Nepal. September,
2013. (Keynote address) (c) Neurobiological aspects
of vulnerability to alcohol dependence (iii) Alcohol and
road safety. International Workshop on Public Health
Approaches for Improving Road Safety of Heavy Vehicle
Fleets in India organized by the Institute of Road
Traffic Education and Centers for Disease Control and
Prevention, New Delhi. November 2013 (iv) Behavioral
sciences research at NIMHANS. University of Liverpool,
Liverpool, October 2013 (v) Burden of alcohol misuse in
India. Workshop on Public Health Communication, Social
Media and Advocacy Campaigns on Preventing Harmful
Effects of Alcohol Use, organized jointly by Public Health
Foundation of India and the Swedish National Institute
of Public Health. New Delhi, December 2013. (Keynote
address) (vi) Social cost of alcohol misuse in India.
Global Alcohol Policy Conference 2013. Seoul, Korea,
October, 2013.
126. Wesley MS, Manjula M. Early maladaptive schemas,
adult attachment and early trauma in individuals
with depression. 17th International and 48th National
Conference of the Indian Academy of Applied Psychology,
Karnataka University, Dharwad, 22-24 May 2013.
2.
Abhishekh HA, Acharya U, Thirthalli J, Phutane V,
Muralidharan K, Gangadhar BN. Ictal EEG non-linear and
high order spectral analysis methods in electroconvulsive
therapy and its clinical utility. Annual Conference of
Association of Physiologists and Pharmacologists 27-30
November 2013. (Harish Gupta Best Paper Award)
3.
Ahalya Raguram. (i) Parent stress management. Training
of Trainers Program on Parenting Skills Development,
Christ College, Bangalore, 29 January 2014 (ii) Emotional
intelligence for effective classroom management. UGC
Sponsored National Workshop organized by Home
Science Association of India – Karnataka Branch and
Smt .VHD. Central Insititute of Home Science, Hosur,
26 July 2013 (Keynote Address) (iii) Inner world
of dysfunctional families. Workshop on Psychiatry
Update -2013, KMC, Manipal, 16-17 November 2013 (iv)
Psychotherapeutic interventions. Orientation to Clinical
Psychology, NIMHANS, 3-4 December 2013.
4.
Ahmed A, Reddy NK, Tahira M.Efficacy of psychosocial
interventions among caregivers of malignant brain tumor
patients. 32nd ANC of ISPSW, Karnataka State Women’s
University, Bijapur. (Dr. M. Chandrasekar Rao
Memorial Award for Best Paper on Research)
5.
Aier A, Veena S, Suman LN. Perceived burden
and treatment expectations of family members of
individuals with intellectual disability. 40th National
Annual Conference of the Indian Association of Clinical
Psychologists, SRM University, Kattankulathur, Tamil
Nadu, 28 February - 2 March 2014.
6.
Ajay KN. (i) Electrophysiological indices of cognition. DST
sponsored Workshop, current physiological techniques – from
basic to applied aspects; emerging trends in neurophysiology:
from cell to systems. NIMHANS, Bangalore, 26 November
2013 (ii) Neural correlates of consciousness and sleep.
Workshop, Research Challenges in EEG Signal Analysis and
Application, Organized by Ambedkar Institute of Technology.
NIMHANS, Bangalore, 26 June 2013 (iii) Principles and
applications of ERP recordings. National Conference,
Electrophysiology & Neurology Trends in Electro Diagnosis
& Research. DY Patil University, Kolhapur, 31 January 2014
(iv) Rajayoga Research at NIMHANS. 7th Spirituality in
Researchers Conference. Brahma Kumaris, Gyan Sarovar,
Rajasthan, 1 September 2013.
7.
Amaresha AC, Reddy NK, Ahmed A, Ross D, Setty VK,
Arthur JA (August, 2011). Strain and coping among
127. Yadav R, Adwani SG, Chandra SR, Kumar KJ, Pal PK.
Cognition in Early Parkinson’s disease and the effect
of laterality of motor symptoms. 20th World Congress
on Parkinson’s disease and Related Disorders, Geneva,
Switzerland, 8-11 December 2013.
B. PRESENTATIONS IN NATIONAL
CONFERENCES
1.
Abhinay. (i) Contrast enhanced MR Angiography. Philips
Gyro Cup. Jayanagar, Bangalore, 14 November 2013
(ii) Types of MR Angiography in Brain. 17th National
Conference of Society of Indian Radiographers.
Mahabaleshwar, Pune, 6-8 December 2013.
Annual Report
2013 (iii) Dead men do tell tales. Brain cutting session,
MERT 2013, 12 October 2013 (iv) Neuropathology
of fungal infections of nervous system. IAMM 2013,
NIMHANS, Bangalore, 12 October 2013 (v) Brain
anatomy – The inside story. 4th National Workshop,
Neuropsychology- Emerging Hope: EEG Neurofeedback
Training (EH:NFT-2013) NIMHANS, Bangalore, 1820 November 2013 (vi) Clinicopathologic conference,
Bangalore Neurological Society, 7 December 2013
(vii) The fevered brain- whodunit? CME, Acute Febrile
Illnesses, 62nd APCON 2013, Aurangabad. 12-15 December
2013 (viii) Slide seminar, KCIAPM, Bowring Institute,
Bangalore, 26 January 2014 (ix) Clinicopathologic
Conference, KNACON 2014, Shivamoga, 15-16 February
2014 (ix) Clinicopathologic Conference and conduct Quiz
program, TROPICON 2014, Chennai, 8-9 March 2014.
caregivers of persons with brain tumor. UGC Sponsored
Social Work Conference Arignar Anna Arts College,
Karaikal, Pondicherry.
8.
9.
10.
Andrade C. (i) Future therapies for Alzheimer’s disease.
World Federation of Neurology, 3rd Teaching Course
in Cognitive Neurology, Bangalore, 5-7 April 2013
(ii) Art of psychiatry: Indian Association of Private
Psychiatry, Puri, 31 August - 1 September 2013 (iii)
Limitations of psychotherapy. Annual Conference
of the Indian Psychiatric Society. (Maharashtra),
Shirdi, 28-29 September 2013 (iv) Bipolar disorder: A
critical examination of recent research for take-home
messages. Annual Conference of the Indian Psychiatric
Society (Central Zone), Lucknow, 19-20 October 2013
(v) CME: Psychopharmacology in the medically ill.
Mid-term CME, Indian Psychiatric Society. (Haryana),
New Delhi, 06 October 2013 (vi) Drug interactions in
geriatric psychopharmacology. CME. Indian Psychiatric
Society (Haryana), Delhi (vii) The future of Alzheimer’s
disease psychopharmacology. CME. Indian Psychiatric
Society (Haryana), Delhi (viii) Mechanism of action of
ECT: Recent research. Symposium, ECT, NIMHANS,
Bangalore, 7 December 2013 (ix) Professional hazards
in Psychiatry. Mid-term CME, Indian Psychiatric
Society (Andhra Pradesh), Warrangal, 9 February 2014.
(Keynote address) (x) Workshop: Drug interactions
and psychotropic medications. Neuropsychiatry CME,
2014, SDM College of Medical Sciences and Hospital,
Dharwad, 23 February 2014 (xi) How to review a
manuscript. 2nd Joint Conference of NIMHANS and Royal
College of Psychiatrists, UK, Bangalore, 7-8 March 2014
(xii) CBT augmentation of pharmacotherapy with special
reference to OCD. Workshop, Mid-Term CME of the
Indian Psychiatric Society. Tamil Nadu, Pondicherry, 16
March 2014.
Anisha Mary Abraham, Sudhir PM, Bantwal G. Health
care providers’ perspectives on barriers to self-care
in type 2 Diabetes Mellitus in India. 40th National
Annual Conference of the Indian Association of Clinical
Psychologists, Chennai, Tamil Nadu. 28 February-1
March 2014.
Anita Mahadevan. CNS infections: Sleeping with the
enemy and Reviving a dying science: Autopsy in current
day practice of pathology (Brain cutting session).
Neuropathology CME, KMC Manipal, 20 July 2013 (ii)
Pathology of drug resistant epilepsy. Colloquium on Drug
Resistant Epilepsy, NIMHANS, Bangalore, 16-18 August
2013-14
11.
Annie P John. Effectiveness of an educational module
on knowledge about, attitude towards an experience
with anti depression drugs in anti depression naïve
depressed patient. National Conference of Indian Society
of Psychiatric Nurses Conference, St. John’s College of
Nursing, Bangalore, 8-10 February 2014.
12.
Anshu K, Laxmi TR. Animal acoustic startle system:
assessing startle response and prepulse inhibition in rats.
APPICON 2013: Pre-conference workshop, sponsored by
DST on Current Physiological Techniques from Basics to
Applied Aspects: Emerging trends in Neurophysiology
from Cell to System, NIMHANS, Bangalore, 26 November
2013.
13.
Anu Mary Varghese, Aparna Sharma, Poojashree Mishra,
Vijayalakshmi K, Harsha HC, Sathyaprabha TN, Srinivas
Bharath, Nalini A, Phalguni Anand Alladi, Raju TR.
Chitotriosidase – a putative biomarker for sporadic
amyotrophic lateral sclerosis. APPICON 2013, Bangalore,
28-30 November 2013 (R. Srinivasan Prize for the
Best Paper)
14.
Anupam Gupta. (i) (a) Botulinum Toxin A in spasticity,
(b) Neuropsychological assessment and cognitive retraining. IAPMR National Mid-Term CME, Mumbai, 2022 September. 2013 (ii)Neurogenic Bladder.MERT CME
Program. NIMHANS, Bengaluru, 19 October 2013 (iii)
Neurogenic bowel dysfunction & management. CME Joint
Program by Bangalore Neurological Society & Bangalore
Urological Society, NIMHANS, Bengaluru, 19 January
2014 (iv) (a) Epidemiology, barriers to admission &
discharge for patients with SCI: ISCoR group experience
Annual Report
2013-14
(b) Cognitive Rehabilitation. 2nd National Indian
federation of Neurological Rehabilitation Conference.
Mumbai, Maharashtra, 27 February 2014 (v) Prevalence
of fatigue in patients with Multiple sclerosis and its
effect in quality of life. 62nd Annual National Conference,
NSICON, Mumbai, 12-15 December 2013.
15.
Aravind Raj E. Health status of Tibetan women in India.
32nd Annual ISPSW, Karnataka State Women’s University,
Bijapur, 20-22 January 2014.
16.
Arivazhagan A, Bhaskara Rao M, Sanjib Sinha,
Chandramouli BA, Satishchandra P. Clinical spectrum of
etiologies and nuances in epilepsy surgery in children An institutional experience. Annual Conference of Indian
Society for Stereotactic & Functional Neurosurgery,
Stereocon 2013, New Delhi, 14-15 September 2013.
17.
Arivazhagan A, Sanjib Sinha, Malla Bhaskara Rao, P
Satishchandra. Disconnection surgeries for drug resistant
epilepsy – indications, learning curve and outcome.
18.
19.
20.
Arivazhagan A, Santosh V, Thennarasu K, Pandey P,
Anandh B, Hegde AS, Chandramouli BA. Long term
survival in GBM patients following RT and temozolomide
– results from the largest prospective cohort treated
with standard uniform adjuvant therapy from India.
62nd Annual Conference of Neurological Society of India.
Mumbai, 12-15 December 2013.
Arivazhagan A. (i) Temporal lobe epilespy - problem
solving approach. Case discussion in Colloquium on Drug
Resistant Epilepsy. NIMHANS, 6-18 August 2013(ii)
Posterior third ventricular tumors - Case discussion.
24th Annual Conference of Indian Society for Pediatric
Neurosurgery, Neuropedicon 2013, Udaipur, Rajasthan.
24-26 October 2013
Arthur Julian Anthony Joseph (i) Group interventions
for substance use disorders. Medical Officers Training
Programme on Substance Use Disorders. NIMHANS
(CAM) Bangalore, 29 July 2013 (ii) Stress management.
Workshop, Personality Development and Stress
Management. Karnataka State Police Training Institute, 12
September 2013 (iii) Brief interventions for substance use
disorders. Two months training programme on addiction
counselling for NRHM social workers from Himachal
Pradesh, NIMHANS (CAM), Bangalore, 26 November
2013.
21.
Arun H Shastry, Balaram Thota, Srividya MR, Shwetha
Durgad, Kota Shravani, Kandavel Thennarasu, Paritosh
Pandey, Hegde AS, Chandramouli BA, Arivazhagan A, Vani
Santosh. Immuno histochemical analysis of novel molecular
markers in astrocytoma - value in aiding diagnosis and
prognosis. 62nd Annual Conference of Neurological Society
of India, Mumbai, 11-14 December 2013 (Herbert Krauss
award for the Best Paper in Neurooncology)
22.
Arun K (i) Technical session. Tobacco Cessation. Karnataka
state level consultation on ban on Tobacco Advertising
Promotion and Sponsorship. 5 July 2013 (ii) Alcohol-the
socio political Neuroscience. Community Medicine CMEAnnapoorna Institute of Medical Sciences, Salem, 24
January 2014 (ii) Anxiety disorder and drug use. Training
on Management of Co-morbid Conditions among Injecting
Drug Users under National AIDS Control Programme
organized by Regional Technical Training Centre, South
Zone, NIMHANS. Bangalore, 19 March 2014.
23.
Arun Vangili. Psychodynamic diagnostic assessment in
child psychiatry. DYPSCAP 2014, Mumbai, Maharashtra,
1-3 March 2014.
24.
Arvinda HR (i) Cerebral Angiogram; Anterior Circulation.
KNACON 2013. Narayana Hrudayalaya, Bangalore, 16
June 2013 (ii) Neurointerventions basics, 30th State
Conference of IRIA, Hubli, 29-30 March 2014.
25.
Ashmeet Nagpal, Ahalya Raguram. Indian adolescents
perceptions of separation- individuation and parental
relationships–a qualitative study. 40th National Annual
Conference of IACP, Chennai, 28 February-2 March 2014.
26.
Ashmeet Nagpal. (i) Zooming in on ‘the solo note’:
preliminary findings on systemic individual marital
therapy. 40th National Annual Conference of Indian
Association of Clinical Psychology, Chennai, 28
February-2 March 2014 (ii) Family formulation,
hypothesization and techniques of family intervention.
Workshop on Psychiatry Update–2013, KMC, Manipal,
16-17 November 2013.
27.
Ashok M, Indira Devi B, Shukla D, Subbakrishna, Neeraj
U, Jamuna Rajeswaran. Quantitative evidence of brain
and its cognitive consequences: A longitudinal study. 31st
Annual National Neurotrauma Symposium, Nashville,
USA, 4-7 August 2013.
Annual Report
28.
Ashok S. Kori, Swarupa U, Nirmala BP. Challenges
experienced in rehabilitating long stay women with
disability in day care center at NIMHANS. 32nd Annual
ISPSW, Karnataka State Women’s University, Bijapur,
20-22 January 2014.
29.
Ashwath Narayan Rao J. Advanced applications of
3 T MRI. National Conference of Society of Indian
Radiographers, Mahabaleshwar, Pune, 6-8 December
2013.
30.
Ashwin YB, Reeta Mani, Madhusudana SN. Human
rabies cases despite pos-exposure treatment: An audit.
15th National Conference of the Association for Prevention
and Control of Rabies in India.Pune, 6-7 July 2013.
31.
Athulaya Jayakumar, Mallika, Jamuna Rajeswaran B.
Neurofeedback training in cerebral hypoxia: a case study
report. 4th Continuing Education in NeuropsychologyNeuropsychological
Rehabilitation
RehabilitationEmerging Hope: EEG NFT. NIMHANS, Bangalore, 18-20
November 2013.
32.
Basavarajappa C, Suresh Kumar K, Kumar CN,
Ravishankar V, Vanamoorthy U, Waghmare A, Sivakumar
T, Mehta U, Thirthalli J. Comparison of IDEAS and
WHODAS 12-item scale cutoffs in persons with psychiatric
disorders referred to psychiatric rehabilitation services of
NIMHANS. National Conference, Research and Services
on Psychiatric Rehabilitation: Focus on Recovery,
NIMHANS, Bangalore, 8-9 March 2014.
33.
Bhadrinarayan V. (i) How to safeguard from Hospital
infection? PG Excel – 2013, Bangalore, 11 August 2013
(ii) Basic principles of ventilation and respiratory care in
the ICU. Navodaya Medical College, Raichur, 24 August
2013 (iii) Post resuscitation care beyond CPR. Annual
Karnataka State Conference, Bangalore, 13- 15 September
2013 (iv) Pediatric traumatic brain injury. 61st Annual
Conference of the Indian Society of Anaesthesiologists,
Guwahati, 26-29 December 2013.
34.
Bhaskar MV, Arun K Gupta, Bharath RD, Pramod K Pal.
Assessment of brain plasticity induced by rtms in patient with
writer cramp using resting state connectivity by simultaneous
EEG-fMRI. 16th Annual Conference of ISNR 2013, Bangalore,
26-29 September 2013. (Best Poster Award)
35.
Bhola P (i) Recovery-oriented services at NIMHANS:
Assessment, home-based rehabilitation and volunteer
2013-14
participation. Annual National Conference of the World
Association of Psychiatric Rehabilitation, Calicut,
Kerala, 20-21 July 2013 (ii) Innovations in psychiatric
rehabilitation services: service delivery and advanced
training in psychiatric rehabilitation at NIMHANS.
National Conference on Research and Services in
Psychiatric Rehabilitation with Focus on Recovery,
NIMHANS, Bangalore, 8-9 March 2014.(iii) Psychosocial
rehabilitation. Psychological Care for Addictive Behaviours
Programme for trainees from Shimla. December,
2013 (iv) Integrating self-reflection into Practice,
How Psychotherapists Develop, Therapist Self-care.
One-day workshop titled Tuning in: Being a reflective
psychotherapist. NIMHANS Centre for Wellbeing,
Bangalore, 4 April 2013 (v) Rehabilitation psychology:
Beyond symptom amelioration. Presentation at
Orientation to Clinical Psychology: Emerging areas. A twoday orientation program organized by the Department of
Clinical Psychology, NIMHANS, Bangalore. 3-4 December
2013 (vi) Health Psychology: The mind-body relationship.
Presentation at Orientation to Clinical Psychology:
Emerging areas. A two-day orientation program organized
by the Department of Clinical Psychology, NIMHANS,
Bangalore, 3-4 December 2013 (vii) Therapist strengths
and limitations, Integrating self-reflection into practice.
Workshop titled Mirror, Mirror on the Wall: Becoming a
self-reflective practitioner. NIMRCPSYCH 2014: 2nd Joint
Conference of NIMHANS and RCPSYCH UK: Training
and learning for the 21st century trainee in Psychiatry,
36.
Bhola P, Mathur S. Session on Suicidal behaviours:
assessment and preventive interventions. Making a
Difference: A workshop on Youth Mental Health for
College Counselors. Department of Clinical Psychology,
11-12 July 2013.
37.
Bindu M Kutty. (i) Mind training and brain plasticity
during the scientific program, ‘Mind Science organised
during the Youth Interfaith Pilgrimage program of
the Foundation for the Universal Responsibility of his
Holiness The Dalai Lama NIMHANS, 8 August 2013
(ii) Polysomnography : A window to assess the brain
Functions’. CME, Current Trends in Neurophysiology.
Little Flower Hospital and Research center, Angamali,
Kerala, 28-29 September 2013 (iii) Polysomnography:
a window to assess the neurobiology of sleep. National
Workshop on ‘Biomedical Systems’ organized by PES
Institute of Technology, Bangalore, 25 October 2013 (iv)
Environmental enrichment: A window to understand the
Annual Report
2013-14
phenomenon of cognitive reserve in the brain-during
the Emerging Hope: EEG Neurofeedback Training
Workshop. NIMHANS, 18-20 November 2013 (v)
Understanding consciousness from illness to wellness.
DST sponsored Workshop, Current Physiological
Techniques – From Basic to Applied Aspects; Emerging
Trends in Neurophysiology: From Cell to Systems.
NIMHANS, Bangalore, 26 November 2013 (vi) Anatomy
and physiology of sleep’ during the 8th National Sleep
Medicine Course. Balaji Medical College, Chennai, 14-15
December 2013 (vii) Neural plasticity and the concept
of cognitive reserve: experimental evidences and newer
concepts. Bangalore Cognition Workshop under the
Learning and Memory Module. IISc, Bangalore,19-21
December 2013 (viii) Mind Training, brain plasticity
and the concept of cognitive reserve. Workshop,
Neurophysiology & Electrophysiology Axxonet Solutions,
Bangalore,9-12 January 2014 (ix) Sleep – a dynamic state
– a revisit & homeostatic and circadian regulation of sleep.
One day CME, Basics of Sleep and Sleep Disorders, Raja
Rajeswari Medical College, Bangalore, 9 March 2014.
38.
39.
Bindu PS, Sonam K, Govindaraju C, Taly AB, Gayathri N,
Srinivas Bharath MM, Arvinda HR, Nagappa M, Sinha
S, Khan NA, Govindaraj P, Vandana N, Thangaraj K.
Pediatric mitochondrial disorders: study from a tertiary
care neurological institute.Mitochondria in Health and
Disease, Bangalore, 18 -20 December 2013.
Bindu PS. (i) Mitochondrial disorders. Overview. Hands
on workshop in Neurochemistry and Electronmicroscopy.
NIMHANS, Bangalore, 18 July 2013 (ii) Clinical
clues to the diagnosis of neurometabolic disorders &
leukoencephalopathies. 16th Annual Conference of Indian
Society of Neuroradiology, Bangalore, 27 September 2013
(iii) Mitochondrial disorders, a diagnostic conundrum.
Child Neurocon. 5th Annual Conference of Association of
Child Neurology, Hyderabad, 9 February 2014.
40.
Bingi Rajeshwari. A comparative study to assess the
knowledge and attitude of school personnel about
Tobacco control policies in schools and training materials
available for implementing tobacco prevention and
control interventions among government and private
school. National Conference of Indian Society of
Psychiatric Nurses Conference, St. John’s College of
Nursing, Arekere, Bangalore, 8-10 February 2014.
41.
Birudu Raju. The unmet psychosocial needs of family care
givers of persons with brain tumors- a qualitative study.
Emerging Health Issues Across Life Stages, University of
Mysore, Mysore. 6-7 March 2014.
42.
Chaitanya G, Sinha S, Satishchandra P. Ripples and
waves: patterns of high frequency oscillations (HFOs) in
absence epilepsy.Colloquium in drug resistant epilepsy.
Bangalore, 16-18 August 2013.
43.
Chandra PS, Girish, Padma, Desai G. Suicide Reporting
for Journalists (Prajavani). Prajavani Office. Bangalore, 8
February 2014.
44.
Chandra SR. (i) Can TMS be used as a biomarker to
differentiate between early Alzheimers disease from
ftd.Indo-German Workshop on Neurobionics 2013 in
Clinical Neurology. JIPMER Puducherry. 15 -17 February
2013 (ii) Metabolic encephalopathy–Diagnosis and
management. 62nd Annual conference of neurological
Society of India, Chennai, 12 December 2013 (iii)
Neuroradiology Conference-16th Annual Conference of
Indian Society of Neuroradiology – Indian Society of
Health & Neuro Sciences, NIMHANS, Bangalore, 2629 September 2013 (iv) Chaired session on Metals and
Brain. Chennai Neuroupdate, Chennai, 24-26 January
2014(v) Chaired session on recent advances. 62nd Annual
Conference of Neurological Society of India. Mumbai,12
December 2013.
45.
Chandrajit Prasad. A case of Rabies–Neuroimaging
Findings. 16th Annual Conference of Indian Society of
Neuroradiology. Bangalore, 26-29 September 2013.
46.
Chetan GK, Sibin MK, Dhanajayan Bhat, Lavanya CH,
Jeru manoj, Geethasree N. Role of P16 deletion and BMI1
copy number variationin Glioma. 39th Indian society of
Human Genetics Annual Conference, Ahmedabad 22-25
January 2014.
47.
Christopher R. (i) Tandem mass spectrometry for
diagnosis of neurometabolic disorders. 2nd Hands-on
workshop on Neurochemistry and Electron microscopy,
NIMHANS, Bangalore 19 July 2013 (ii) Investigation of
lysosomal storage disorders, Programme of awareness
of Lysosomal Storage Disorders and PID, Indira Gandhi
Institute of Child Health, Bangalore, 9 November 2013 (iii)
Inborn errors of metabolism: recent advances in diagnosis
and screening, CME, Inborn Errors of Metabolism, Raja
Rajeshwari Medical College and Hospital, Bangalore, 12
December 2013 (iv) Laboratory diagnosis and prenatal
screening of IEM, CME, Inborn Errors of Metabolism,
Annual Report
Satishchandra P. Predictors of spontaneous seizure
remission in patients of medically refractory epilepsy due to
mesial temporal sclerosis : A preliminary study. Colloquium
in Drug Resistant Epilepsy, Bangalore, 16 -18 August 2013.
Sri Manakula Vinayaga Medical College and Hospital,
Puducherry, 21 February 2014.
48.
Dania Jose, Sri Mahavir Agarwal, Janardhanan
C.
Narayanaswamy,
Sunil
Kalmady,
Ganesan
Venkatasubramanian, Janardhan Reddy YC. The
Neurohemodynamic substrates of response inhibition
in medication naïve OCD: an fMRI study using go/nogo task. 43rd Annual Meeting of Society for neuroscience.
Sandiego, USA, November 2013.
49.
Deepa S, Bindu PS, Gayathri N. Presence of inflammation
is not always inflammatory disease – MYOCON-2014.
Chennai, January 2014.
50.
Desai A. Diagnosing Dengue: the role of the laboratory,
Brain Storming Conference on Dengue Scenario in India,
Madurai, 25-26 July 2013.
51.
Desai G. (i) Use of psychotropic medication in pregnancy
and breastfeeding on interface between Obstetrics and
psychiatry conducted BSOG. BMC auditorium, Bangalore,
26 May 2013 (ii) Psychotropics during pregnancy
and lactation. (a) 2nd Annual State Level Conference,
Psychiatry Society of Goa, Panaji, 02 June 2013 (b)
KANCIPS, Psychiatry Society of Karnataka, Hassan, 4
August 2013.
52.
Dhananjaya I Bhat. Use of amniotic membrane as a wrap for
nerve anastamosis. XV WFNS, Seoul, 8-13 September 2013.
53.
Dhaval P Shukla (i) Outcome after diffuse cerebral injury.
Annual Conference of Neurotrauma Society of India,
Guwahati, 2013 (ii) Post-traumatic cephalalgia. AIIMS
Annual Neurotrauma Conference, New Delhi, 2013 (iii)
Mild traumatic brain injury sequelae. AIIMS Annual
Neurotrauma Conference, New Delhi, 2013 (iv) Early
bladder management in spinal cord injury. Bangalore
Neurology Society, Neurourology CME, Bangalore,
2014 (v) Common neurosurgical problems in children.
Annual Conference of Karnataka Neuroscience Academy,
Shimoga, Bangalore, 2014 (vi) Paroxysmal sympathetic
hyperactivity in a child with moyamoya disease. Annual
conference of Indian Society of Pediatric Neurosurgery,
Udaipur, 2013 (vii) Neuroepithelial tumors of cerebellopontine angle in children. Annual conference of Indian
Society of Pediatric Neurosurgery, Udaipur, 2013.
54.
Dhiman V, Sinha S, Arivazhagan A, Mahadevan A,
Bharath RD, Saini J, Jamuna R, Rao MB, Shankar SK,
2013-14
55.
Diksy Jose, Sailaxmi Gandhi, Geetha Desai. Recovery
from schizophrenia: a qualitative analysis of patient
perspectives. National Conference on Research and
Service in Psychosocial Rehabilitation, NIMHANS, 8-9
March 2014.
56.
Divya Sadana, Jamuna Rajeswaran. (i) Neuropsychological
rehabilitation in schizophrenia: case series.(ii)
Neuropsychological Rehabilitation in a case of cerebral
hypoxia due to partial hanging. 4th Continuing Education
in Neuropsychology-Neuropsychological RehabilitationEmerging Hope: EEG NFT, NIMHANS, Bangalore, 18-20
November 2013.
57.
Dwarakanath Srinivas (i) Lesioning in multi etiological
tremor. 2nd update on Functional Neurosurgery and
Radiosurgery. Medanta the Medicity, Gurgaon, April
2013(ii) (a) Pediatric severe head injuries – dilemmas
and decisions (b) Post traumatic hydrocephalus AIIMS
Annual update on Neurotrauma. 31 August-1 September
2014 (iii) Management strategies in arterio-venous
malformations. Annual meeting of Neuro-radiology
society of India, Bangalore, 28-29 September 2013 (iv)
Surgical management of Tremor. 3rd Annual Conference
of the Neurological Surgeon’s Society of India, NSSI
2014. Rishikesh, 28 February- 2 March 2014 (v)(a)
Surgical management of cavernous sinus hemangiomas
(b) Craniosynostosis: Surgical management strategies,
Thalamotomy in multietiological tremor: outcomes.
15th WFNS, Seoul 8-13 September 2013 (vi) Surgical
management of brainstem cavernomas. NEUROVASCON
2013, Hyderabad, 21-22 September 2013 (vii) Surgical
management of multi compartmental trigeminal
schwannomas. Skull Base 2013. Chandigarh, 4-6
October 2013 (viii) Endoscopic management of thoracic
spine – NIMHANS experience. 6th World Congress of
Neuroendoscopy, Mumbai, 8-11 December 2013.
58.
Elias JK, Michael RJ, Mehrotra S. Mind Matters! Faculty
Development Program for college teachers from Kerala
state, Institute of Social and Economic Change, 13
February 2014.
59.
Fasli Sidheek, Jamuna Rajeswaran, Rajakumari
K. Neurofeedback training in ADHD- A qualitative
Annual Report
2013-14
report. 4th Continuing Education in NeuropsychologyNeuropsychological
Rehabilitation
RehabilitationEmerging Hope: EEG NFT, NIMHANS, Bangalore, 18-20
November 2013.
60.
61.
62.
63.
64.
Gandhi S, Chinnaya HP, Rathanmma, Thirthalli J, Bhola
P, Nirmala BP, Sivakumar T, Chaturvedi SK. Individual
training and placement in psychiatric rehabilitation
setting- a case study report. National Conference on
Research and Service in Psychosocial Rehabilitation,
NIMHANS, 8-9 March 2014.
Gayathri N (i) Histotechniques – Its role in diagnosis,
Bangalore, October 2013 (ii) Congenital muscular
dystrophies. MYOCON, Chennai, January 2014 (iii)
Mitochondrial disorders - Pathology of skeletal muscle
tissue. 38th Mahabaleshwar series, Mahabaleshwar,
January 2014.
Gayatri Hegde, Jamuna Rajeswaran, John Vijaysagar. (i)
Effect of EEG neurofeedback training in children with mild
mental retardation. 48th National and 17th International
Conference of – The Indian Academy of Applied
Psychology. Karnatak University, Dharwad, 22-24 May
2013 (b) 4th Continuing Education in NeuropsychologyNeuropsychological Rehabilitation-Emerging Hope: EEG
NFT, NIMHANS, Bangalore, 18-20 November 2013.
Girimaji SC (i) Introduction to child psychotherapy. CME
Program on Psychotherapy, KMC, Manipal November
2013 (ii) Introduction and overview on violence and
sexual abuse of persons with disabilities. Seminar on Early
Intervention & Issues of Violence & Sexual Harassment
of Persons with Disabilities. Bangalore, November 2013
(iii) Recent trends in classification in child and adolescent
psychiatry. IPS (KC) CME on Recent Advances in
Classification, Bangalore, February 2014 (iv) Approach
to intellectual disability, scholastic backwardness and
oppositional defiant disorder. CME on Child Psychiatric
Disorders, Jaipur, March 2014.
Girish Baburao Kulkarni. Heart and Stroke 2013
Conference –AIIMS. New Delhi, 8-10 November 2013 (ii)
Profile of patients with cerebral venous sinus thrombosis
with cerebellar involvement. National Conference of
Indian Stroke Association ISACON 2014. Trivendrum,
14-16 March 2014 (iii) Ischemic stroke clinician’s
perspective. Indian Society of Neuroradiology, Bangalore,
26-29 October 2013.
65.
Gopal Krishna KN. Dexmeditomedine as an anaesthetic
adjuvant in patients undergoing trans-sphenoidal
resection of pituitary tumor. 61st Annual Conference of
the Indian Society of Anaesthesiologists, Guwahati, 2629 December 2013.
66.
Gope R. RNAi and cancer research. DBT Sponsored
Workshop. RNAi technology and its application.
Maharani’s Science College for women, Bangalore, 10
February 2014.
67.
Gorky Medhi, Subhendu Parida, Vinay Hegde, Jitender
Saini, Hima Pendharkar. Cortical malformation with
aberrant course of corticospinal tract in a case of infantile
hemiplegia. 16th Annual Conference of Indian society of
Neuroradiology. Bangalore, 26-29 September 2013.
68.
Govindaraju C, Sonam K, Bindu PS, Gayathri N, Govindaraju
P, Khan NA, Vandana N, Arvinda HR,Thangaraj K, Taly
AB. Genotypic observations in patients with mitochondrial
disorders: a study on 320 patients from south India. 21st
Annual conference of Indian Academy of Neurology.
Indore, 24-27 October 2013.
69.
Govindaraju C, Sonam K, Bindu PS, Gayathri N,
Govindaraju P, Khan NA, Vandana N, Arvinda
HR,Thangaraj K, Taly AB. Imaging observations in
patients with mitochondrial cytopathy from south indian
tertiary care centre. 3rd Annual Conference of Society for
Mitochondrial Research and Medicine. Bangalore, 19-20
December 2013.
70.
Gupta AK. (i) Role of interventional radiology in
management of dural arteriovenous malformation.
Annual Neurological Society of India Conference.
Mumbai, 12-15 December 2013 (ii) Cerebral AVM - NBCA
embolization-technique & results. Microneurosurgery
and Neuroendovascular Workshop. Sri Sathya Sai
Institute of Higher Medical Sciences, Bangalore, 16-17
February 2014 (iii) Cerebral AVM - NBCA EmbolizationTechnique & Results. Stroke and Advanced neurovascular
intervention. Kolkata Institute of Neurosciences. Kolkata,
1-2 March 2014 (iv) CME, Emergency and Trauma
radiology, Department of Radio diagnosis & Imaging,
Chandigarh. 4-5 May 2013.
71.
Gupta HK, Sharma MK, Ramana GV. Exploration of
psychological distress among caregivers in Ayurvedic
treatment setting. 66th ANCIPS, Pune, 16-19 January 2014.
Annual Report
72.
Hargun Ahluwalia, Jamuna Rajeswaran, John P John.
Neurofeedback training in chronic Schizophrenia : a case
study. 4th Continuing Education in NeuropsychologyNeuropsychological
Rehabilitation
RehabilitationEmerging Hope: EEG NFT, NIMHANS, Bangalore, 18-20
November 2013.
73.
Hegde S. Music cognition: An overview. Seminar
organized for Jagadish Bose National Science talent search
students (Undergraduate students in Basic Sciences,
Engineering, and Medicine). NIMHANS, Bangalore,
13 June 2013 (ii) Music and cognition: Neural basis of
music perception and cognition. Mind Science. Seminar
organized by Department of Neurophysiology, NIMHANS
in association with the Youth Interfaith pilgrimage
program of the Foundation for universal responsibility
of His Holiness the Dalai Lama, NIMHANS, Banglaore,
8 August 2013 (iii) Neuromusicology: its contribution to
evidenced based music therapy practice-Nadamanthana
Music Therapy Workshop, Organized by Meera Center
for Music Therapy Education and Research. Jain College,
Bangalore, 15 September 2013.
74.
Herbert HS, Manjula M. (i) Keeping the motivation
up: Maintaining good peer relationships. Workshop
on Meeting the challenge: A workshop on handling
academics effectively. Christ Pre-University Residential
College, Bangalore, 11-12 June 2013 (ii) Managing healthy
relationships with peers and parents. Workshop, Making
a difference: Youth Mental Health for College Counselors,
NIMHANS, Bangalore, 11- 12 July 2013 (iii) Resilience
based intervention in college youth: an efficacy study.
40th National Annual Conference of Indian Association
of Clinical Psychologist, SRM University, Chennai, Tamil
Nadu, 28 February - 2 March 2014.
75.
76.
Hima Pendharkar, Gupta AK, Shubhendu, Anantram G
(i) Neurovascular manifestations of Neurofibromatosis
type 1. 16th Annual Conference of Indian Society of
Neuroradiology. Bangalore, 26-29 September 2013 (ii)
Complication in neurointerventions. 10th Monsoon Meet
Goa, 29 August-2 September 2013 (iii) Management
of carotico cavernous fistula. 67th Annual Conference of
Indian Radiological & Imaging Association. Agra, 2326 January 2014 (iv) What’s new in stroke imaging?
Symposium, Advanced MRI Application in Neuro, MSK
& Body Imaging. Gurgaon, 21-23 February 2014.
Hirisave U (i) Parental pressure and child development.
Workshop, VHT Institute, Bangalore, 18 April 2013
2013-14
(ii) Emotional development in children. Rashtrotana
Pratisthana, Bangalore 24 May 2013 (iii) Child
development theories relevant for intervention. Training
of Trainers Programme, Child Protection Personnel of
Karnataka, Bangalore, July- August 2013 (iv) Emotional
problems of children. Workshop, Karnataka Branch of
IPS, Hassan, 9 August 2013 (v) Promotive intervention for
young children. Workshop organized by NIMHANS and
ICSSR, NIMHANS, 21 September 2013 (vi) Sex education
for parents of children and adolescents with mental
retardation, Organized by Seva in Action and NIMHANS,
NIMHANS, 23 November 2013 (vii) Psychological
Testing. Parikrama, programme organized for teachers,
2 December 2013 (viii) Psychotherapy with Children.
Seminar organized by Department of Clinical Psychology
for post graduates in Psychology, 3 December 2013 (ix)
Interactive session on child psychology with DMPH
Psychologists, 6-18 December 2013 (x) Benefits of hobbies
for Children. Hobby Master (NGO) Sarla Birla Academy,
Bangalore, 12 January 2014 (xi) Sentence completion test
for children for trainee counsellors. Prasanna Counseling
Centre, Bangalore, 25 January 2014 (xii) Testing of
intellectual functions. Regional workshop organized by
Karnataka Government for Officers from the Department
of Disability, 7 Februrary 2014 (xiii) Child Psychotherapy.
CME, Department of Child Psychiatry, DY Patil medical
college and Hospital, Mumbai, 28 February 2014.
77.
Hurmath Fathima K, Nandakumar DN. Role of IL-1beta
on proliferation and activity of gelatinase subfamily of
MMPs in U87MG glioma cells. 33rd Annual Convention of
Indian Association for Cancer Research, Kollam, Kerala,
13-15 February 2014.
78.
Indupriya B, Jamuna Rajeswaran, Nupur Pruthi.
Creativity and cognitive functions in traumatic brain
injury. 40th National Annual Conference of Indian
Association of Clinical Psychologist. SRM Medical
College, Hospital and Research Institute, Kattankulathur,
Chennai. 28 January-2 February 2014 (Best Paper
Award)
79.
Jagath Lal G. Cranio-orbital meningiomas: Management
and Outcome. 15th Annual Conference of Skull base society
of India. Postgraduate Institute of Medical Education and
Research, (PGIMER), Chandigarh, 5 October 2013.
80.
Janardhan Reddy YC. (i) Childhood OCD. IPS,
Karnataka Chapter PG CME, KS Hegde Medical
Academy, NITTE University, Mangalore, February 2014
Annual Report
2013-14
(ii) Cognitive-behavior therapy of obsessions. Art of
Psychiatry, Indian Association of Private Psychiatry. Puri,
Orissa, 2013 (iii) Clinical course and outcome in OCD.
Workshop, CBT: Applications in Emotional Disorders.
NIMHANS, Bangalore, 2013 (iv) Classification of OCD &
related disorders: DSM 5 & ICD 11. CME, organized by the
IPS, Karnataka chapter and NIMHANS, February 2014
(v) Treatment of Bipolar depression. Symposium, World
Bipolar day. Organized by the Asha Hospital, Hyderabad.
March 2014.
81.
Janardhana N. CBR and mental illness. ROSES
Conference, 8-9 March 2014
82.
Janardhanan CN. Deficient hippocampal activation during
learned irrelevance in high risk subjects of schizophrenia:
an fMRI study. Annual National Conference of the Indian
Psychiatric Society, January 2014. (Young Psychiatrist
Award)
83.
84.
85.
86.
Jayanthi KN. Legal guidelines for nurses. One day Seminar
Dr. RN Moorthy Continuing Nursing Education, Legal
and Ethical issues in nursing. NIMHANS, Bangalore,
November 2013.
Jayaram M. Age related changes on hearing and perception
of speech. National Conference,Ageing and its Effects on
Hearing, Speech, Language and Communication. Institute
of Speech and Hearing, Bangalore, 19-21 September 2013
(ii) Plagiaism in scientific writing. 46th Annual Conference
of the ISHA. Kochi, 5-7 February 2014.
Jitender Saini (i) Cross sectional anatomy of neck. CME,
Neck Imaging. Davangere, 20 April 2013 (ii) Imaging
of demyelinating disorders. CME, Advanced Imaging
Techniques. NIMHANS, Bangalore, 12 May 2013 (iii)
Imaging in Parkinson’s disease. Parkinson’s disease
Education Programme for Neurology, Neurophysiology
Students. Bangalore, 5-7 March 2014.
John Vijay Sagar K. (i) Psychiatric emergencies in children
and adolescents. Pedicriticon -2013 (State Conference of
IAP Intensive Care Chapter of Karnataka and 3rd North
Karnataka CME of IAP), May 2013 (ii) Psychosocial issues
in adolescence. Bangalore Obstetics and Gynaecology
Society CME, September 2013 (iii) Mental health disorders
in adolescents in life skills educators’ Workshop on
Empowering Adolescents – Promotion of Psychosocial
Competence using Life Skills Education, NIMHANS, 27
September 2013, 14 March 2014. (iv) School refusal. Indian
Academy of Pediatrics-Tumkur Chapter CME, November
2013(v) Specific learning disorders. Seminar on learning
disability (Steps to strides) organized by Times Foundation
at Gems Business School, Bangalore, 14 December 2013
(vi) Evaluation and Management of ADHD. Psychiatry PG
CME, KSHEMA, Mangalore, February 2014.
87.
Joshi PG. (i) Signaling networks in the brain: Role of
neuron-glia crosstalk. Recent Perspectives in Biophysics.
PGIMER Chandigarh, 11 May 2013 (ii) New insights into
brain signaling: Neuron-glia crosstalk. ICMR Workshop
for Advancement of Physiological Sciences in India,
Bangalore, 21-22 September 2013.
88.
Jothimani G. (i) (a) Assessment of prevalence, knowledge,
attitude, behavior and interpersonal factors related to
the use of tobacco among adolescents (b) Knowledge and
attitude on tobacco use among adolescence. National
Conference of Indian Society of Psychiatric Nurses, St.
John’s College of Nursing, Bangalore, 8-10 February 2014.
89.
Jyothi EK, Anjana Shenoy, Ravikumar R. A clinical isolate
of blandm-1 positive pseudomonas putidain a tertiary
care hospital.MICROCON 2013, Hyderabad, 20-24
November 2013.
90.
Kailash S, Chethan B, Suresh VC, Umamaheshwari
V, Vinutha R, Waghmare A, Kumar CN, Sivakumar T.
Comparison of disability assessed on different versions of
12 items WHODAS 2.0 in psychiatric patients. National
Conference on Research and Service in Psychosocial
Rehabilitation, NIMHANS, 8-9 March 2014.
91.
Kamal Kishore. (i) Application of generalized estimating
equations technique for handling longitudinal data with
MCAR and MAR pattern. 12th Biennial Conference of
International Biometric Society- Indian Region. National
Institute for Research in Tuberculosis, Chetput, Chennai,
27-28 December 2013 (ii) Comparing linear mixed
model and generalized estimating equations techniques
for longitudinal data. 31st Annual Conference of Indian
Society for Medical Statistics, Christian Medical College,
Vellore, 24-26 October 2013.
92.
Kavitha P, Sekar K. (i) Evolution of devadasi system from
family and societal perspective. 32nd Annual ISPSW,
Karnataka State Women’s University, Bijapur, 20-22
January 2014.
Annual Report
93.
94.
95.
96.
Kori A, Ahmed A, Muralidhar D, Reddy D, Hamza A.
Spectrum of psycho-social interventions in psychiatric
social work setting- review of case records at NIMHANS.
32nd National Annual Conference of the Indian Society of
Professional Social Work, Bijapur, 20-22 January 2014.
(Mr. Ashok Kori, was awarded the Gold Medal)
Kumar CN. Community based rehabilitation: the
NIMHANS experience. Research and Services on
Psychiatric Rehabilitation: Focus on Recovery,
NIMHANS, March 2014.
Kumar D. (i) Psychological perspective/understanding of
children and adolescents in conflict with law; Application
of Psychology in forensic set-ups. Refresher Program,
Odissa Judicial Academy, Cuttack, 26 December
2013 (ii) Shaking the unshakeable: Metacognitive
therapy for delusions. Annual National Conference of
the Indian Psychiatric Society, Pune, 16-19 January
2014 (iii) Psychotherapies for psychotic experiences:
contributions of translational psychological research.
National Annual Conference of the Indian Association of
Clinical Psychologists, Chennai, 28 February- 2 March
2014 (iv) Cognitive aspects of psychiatric rehabilitation.
ROSES Conference, Psychiatric Rehabilitation services,
NIMHANS, Bangalore, 8-9 March 2014 (v) How to
motivate an interviewee during interview process:
Strategies that can be helpful in enhancing information
gathering. Development of a Curriculum to Train
Investigative Officers in Scientific Interviewing Methods,
NIMHANS, Bangalore, 23 December 2014.
Kumar KJ (i) Psycho-somatic and memory management.
Half a day workshop for Professional Certificate
Programme on tea tasting and Marketing. Indian
Institute of Plantation Management. Govt of India,
Bangalore, 18 June 2013 (ii) Neuropsychology: the
brain behaviour relationship. Orientation to Clinical
Psychology Programme for Masters’s level students
(Psychology) of various Universities, NIMHANS
Bangalore, 3-4 November 2013 (iii) Emerging trends in
neuropsychological rehabilitation. One day workshop,
National Seminar on Neuropsychological Rehabilitation,
Ethiraj College for Women, Chennai, 18 December 2013
(iv) (a) Preconference workshop, Neuropsychological
Rehabilitation in Head Injury 27 February 2013 (b)
Cognitive retraining in Schizophrenia. 40th National
Conference of Indian Association of Clinical Psychologist,
Kattankulathur, Chennai, 27 February-1 March 2014 (v)
Cognitive aspects of psychiatric rehabilitation. National
2013-14
Conference on Research and Services in Psychiatric
Rehabilitation: Focus on Recovery. NIMHANS, 8-9
March 2014.
97.
Kumar N, Mohan V, Sinha S, Anand A, Satishchandra
P. Role of ABCB1 and ABCC2 genes in drug resistant
partial epilepsy: A study from south India. IANCON 2013.
Indore, 24-27 October 2013.
98.
Kumar R, Kumar KJ, Benegal V (i) Underlying hypothesis
of decision making process on iowa gambling task.
International Integrated Clinical Neuroscience Forum,
New Delhi, 14-15 September 2013 (ii) Impulsivity might
be a predisposing vulnerability for high risk alcoholism.
International Conference on Cognition, Emotion and Action.
IIT Gandhinagar, Gujrat, 6-8 December 2013 (iii) Alcoholism:
an understanding from neuropsychology perspective. 2nd
International Conference, Recent Advances in Cognition and
Health, BHU, Varanasi, 23-25 January 2014.
99.
Lakshmanan Sethuraman, Deepak Jayarajan, Arun
Kandasamy, Ngaitlang Mary Tariang, Prabhat Chand,
Pratima Murthy, Vivek Benegal.Centre for Addiction
Medicine. CAM after care services – 1year follow-up
of in-patients with substance use disorders. National
Conference – Psychiatric Rehabilitation Services and
Research, 7-8 March 2014.
100. Lakshmi J, Paulomi M. Sudhir, Eesha Sharma, Shyam
Sundar A, Janardhan Reddy YC. Mindfulness integrated
cognitive behavior therapy with a patient with body
dysmorphic disorder. 46th Annual Conference of Indian
Psychiatric Society South Zone/ Kumarokam, 18-20
October 2013.
101. Lakshmi J, Sudhir PM, Sharma E. Shyam Sundar, Reddy
YCJ. Mindfulness integrated CBT with a patient with
body dysmorphic disorder. 46th Annual Conference
of the Indian Psychiatric Society-South Zone branch,
Kumarakom, Kottayam, Kerala, 19 October 2013.
102. Lalitha K. (i) Innovations towards nursing excellence
Regional Workshop – Organised by M.Sc Nursing
Students, Dayananda Sagar College of Nursing, Bangalore,
3 April 2013 (ii) Revelation of Nursing Informatics.
Workshop organized by PG students, AECS Maaruti
College of Nursing, Bangalore, 3 April 2013 (iii) Ward
management techniques. Workshop, Strengthening the
Role of Nursing Administrators, Sri Jayadeva Institute
of Cardiovascular Sciences and Research, Bangalore, 4
Annual Report
2013-14
May 2013 (iv) Interpersonal relationship for a teacher
& student mentoring, two-Day Workshop,Institutional
Integration and Enhancing Teaching Effectiveness,
Kristu Jayanthi College, Bangalore, 4 June 2013 (v)
Empowering nursing practice – Breaking complexities.
National Conference, Avant Gardism – Cutting edges
in Nurse Learning– Context Based Learning , Saveetha
College of Nursing, Tamil Nadu, 14 June 2013. (vi) (a)
Overview of Nursing Theories (b) Utilization of theories
in practice in psychiatric nursing speciality. National
Conference, Theoretical Foundations & its applications
in Nursing. RVS College of Nursing, Coimbatore, 12 July
2013 (vii) (a) Perinatal psychiatric disorders (b) Ethical
and legal issues in promoting the mental health rights of
the vulnerable. National Nursing Conference. Theme:
Nursing insight into the Mental Health of Vulnerable,
Ganga Institute of Health Sciences, Coimbatore, 14
September 2013 (viii) Policies and programmes for Senior
Citizens.National Conference–Dhanalakshmi Srinivasan
College of Nursing.Tamil Nadu. 12 October 2013 (ix)
Types of quantitative research and selection of research
problem. Epidemiology of Chronic Diseases: Nursing
Research Perspectives. 17th NRSI Annual National
Conference–Theme: Manikaka Topawala Institute of
Nursing, Gujarat, 25-27 October 2013 (x) (a) Analysis
of quantitative research (b) Common ethical issues in
nursing research (c) Concept of standardized tool, validity
of measuring instruments, tools for data collection (d)
Conducting qualitative nursing research (e) Determining
the limitations of research study (f) Developing CFW for
research (g) Ethics in Nursing research (h) Interpretation
and dissemination of qualitative findings (i) Manuscript
writing (j)Population and sampling (k) Preparing a
research protocol (l) Sample size determination (m)
Tool testing and Pilot study (n) Tools and data collection
(o) Validity of measuring instrument (p)Vital Health
Statistics. M.Sc Nursing students – LGB Regional Institute
of Mental Health, Tezpur, Assam, 1-3 November 2013 (xi)
Patients rights and application of basic ethical principles
in nursing practice Ethical and Legal Guidelines for
Nurses. Dr. Ramachandra N. Moorthy CME-One Day
Seminar. College of Nursing, NIMHANS, Bangalore, 27
November 2013 (xii) Changing the outlook of quantitative
research. National Level Workshop, Building on the Best:
Accentuating your expertise in research and statistics.
Organised by Continuing Education. Department of JSS
College of Nursing. Mysore, 16 December 2013 (xiii)
(a) Research Design as applied in Nursing Research (b)
Research problem selection (c) Tool preparation (d)
Standardisation of tools reliability and validity. Pre Ph.D
Workshop. PD Hinduja College of Nursing, Mumbai, 24
January 2014 (xiv) Suicide and its Management. One Day
Workshop, Psychiatric Emergencies and its management.
Funded by Dr. RN Moorthy Foundation Funds, Dept. of
Nursing, NIMHANS, Bangalore, 26 February 2014.
103. Lavanya CH, Chetan GK, Sibin MK, Manoj MJ, Bharath
MM. Promoter methylation of PTEN gene in high grade
gliomas. 39th Indian society of Human Genetics Annual
Conference, Ahmedabad, 22-25 January 2014.
104. Lavanya TP, Manjula M. Emotion regulation and
psychological problems among college students. National
Annual Conference of Indian Association of Clinical
Psychologists, SRM University, Chennai, Tamil Nadu, 28
February - 2 March 2014.
105. Laxmi T Rao. (i) Environmental manipulation in
early and late in life on adult brain plasticity. 31st
International Annual Conference of Indian Academy
of Neurosciences. Emerging trends and challenges in
Neuroscience. Allahabad, Uttar Pradesh, 25-27 October
2013 (ii) Research Methods Pre-conference appicon
2013.DST Sponsored Workshop, Emerging Trends in
Neurophysiology: From Cell to Systems. NIMHANS,
Bangalore, 26 November 2013 (iii) Stress and cognition:
historical and functional analysis. 4th National Workshop,
Emerging Hope: Neurofeedback Training. NIMHANS,
Bangalore, 18-20 November 2013 (iv) Early life Stress
and cognition: Historical and functional analysis. in:
Brain and Cognition Workshop Bangalore 8-21 December
2013 (v) The emotional brain. Mind Science. 10th Youth
Interfaith Piligrimage program 2013, Foundation for
Universal responsibility of his Holiness the Dalai Lama,
NIMHANS, Bangalore, 8 August 2013.
106. Leeshma K, Jamuna Rajeswaran, Nupur Pruthi. The effect
of traumatic brain injury on cognitive and behavioural
functions in adolescents. 40th National Annual
Conference of Indian Association of Clinical Psychologist,
SRM Medical College, Hospital and Research Institute,
Kattankulathur, Chennai. 28 January-2 February 2014.
107. Madhavadas S, Kutty BM, Subramanian S. Development
of non-transgenic animal model for Alzheimer disease.
59th Annual National Conference of Association of
Physiologists and Pharmacologists of India. Bangalore,
28-30 November 2013.
Annual Report
108. Madhusudana SN, Manjunatha MV, Reeta Mani. Dual
role of immune response in rabies encephalitis. Studies
in mice and their implications in human disease. 15th
National Conference of the Association for Prevention
and Control of Rabies in India, 6-7 July 2013.
109. Mahati K, Bhagya V, Christofer T, Raju TR,
Shankaranarayana Rao BS. Concomitant enriched
environment and antidepressant treatment restores
depression-induced aberrant neuronal plasticity and
impaired spatial learning. 59th Annual Conference of
the Association of Physiologists and Pharmacologists of
India, Bangalore, 28 - 30 November 2013.
110. Malla
Bhaskara
Rao.
(i)
Selective
amygdalohippocampectomy and anterior temporal
lobectomy. 13th ISSFN meeting. New Delhi, 14-15
September 2013 (ii) How to develop epilepsy surgery
programmes in India. 62nd Annual meeting of the
NSI, Mumbai (iii) Epilepsy Surgery. Neurovision.
Visakhapatnam, 31 August - 1 September 2013 (iv)
Surgery for temporal lobe epilepsy. 3rd Annual Conference
of the Karnataka Neurosciences Academy, 15-16 June
2013 (v) Surgery for epilepsy. CGHS Doctors Forum as
chief guest, Bangalore.
111. Maltesh Kambali, Pradeep K Mishra, Preethi Hegde
and Laxmi TR. Classical fear conditioning: a model for
associative learning and memory. APPICON 2013: Preconference Workshop, Current Physiological Techniques
from Basics to Applied Aspects: Emerging trends in
Neurophysiology from Cell to System; NIMHANS,
Bangalore, 26 November 2013.
112. Manjula M (i) Handling exam stress effectively.
Workshop for Engineering students. Indian Institute
of Technology, Hyderabad, 3 April 2013 (ii) Stresscauses, responses and coping; improving self esteem
– helpful thinking. Workshop, Meeting the Challenge:
A workshop on Handling Academics Effectively. Christ
Pre-University Residential College, Bangalore, 1112 June 2013 (iii) Stress and common mental health
problems in students; academic stress: assessment
and management; heterosexual relationships in young
people: issues and intervention. Making a difference:
A workshop on Youth Mental Health for College
Counselors, NIMHANS, Bangalore, 11-12 July 2013 (iv)
Women mental health. Workshop- Health Education for
Mental, Neurological and Substance Abuse Disorders
for Lady Health Visitor Trainees. NIMHANS, Bangalore,
2013-14
22-26 July 2013 (v) Cognitive behavioural assessment;
cognitive model of depression; behavioural strategies
in CBT. Cognitive Behaviour Therapy: Principles and
Applications, NIMHANS, Bangalore, 13-14 August 2013
(vi) Counseling: basic principles and skills. Training of
Counselors under the National Programme for Prevention
and Control of Cancer, Diabetes, Cardiovascular diseases
and Stroke. NIMHANS, Bangalore, 20 August 2013
(vii) Essentials of interpersonal relationships; making
and maintaining romantic relationships. Maintaining
healthy relationships. A Workshop for Youth. Indian
Institute of Science, Bangalore, 19 September 2013 (viii)
Stress identification and management techniques. Stress
management Training Program For Managers Toyota
Motor Private Limited, Bidadi. NIMHANS, Bangalore, 5
October 2013 (ix) Essentials of interpersonal relationships
and counseling in romantic relationships. Workshop,
Maintaining Healthy Interpersonal Relationships for
Youth. NIMHANS Centre for well being, Bangalore, 12
November 2013 (x) Cognitive behavioral assessment in
OCD: identifying dysfunctional beliefs and assumptions;
Cognitive behavioural models and assessment in social
phobia. Workshop, CBT: Applications in Emotional
Disorders. NIMHANS, Bangalore, 15-16 November 2013
(xi) Facing exams effectively. (a) Workshop for Post
Graduate Students of Jain University. Bangalore, 6 April
2013 (b) NIMHANS Centre for Well Being, Bangalore,
1 March 2013, 7 December 2013 (xii) Emotions and its
regulation. Workshop, Emotion Regulation for Healthy
Living. NIMHANS Centre for Well Being, Bangalore, 21
December 2013 (xiii) Women mental health issues and
challenges. UGC Sponsored two day National Seminar,
Psychological Issues and Challenges Related to Women
and Children. Mahrani’s Arts and Commerce College,
Bangalore, 21-22 March 2014 (xiv) Basic skills of
counseling. Training-cum-refresher Program for Family
Counseling Centre Stakeholders. NIMHANS, Bangalore,
18 March 2014.
113. Manjula M, Seema P Nambiar. Stress management.
Trainees from Shimla. NIMHANS, Bangalore, 27
December 2013.
114. Manjula V. Managing healthy relationships – making and
maintaining healthy relationships, dealing with break ups.
40th National Annual Conference of Indian Association of
Clinical Psychology, Chennai, 28 February-2 March 2014.
115. Manjula. Screening for the novel potential therapeutic
modulators for the flip form of ionotropic glutamate
Annual Report
2013-14
receptors 2 (iGluA2). Recent Advances in Computational
Drug Design, Bangalore, 16-17 September 2013.
116. Manjunatha MV, Nandita Hazra, Ashwin Belludi, Reeta
Mani, Madhusudhana SN. Th1 and Th2 cell responses
following intradermal administration of rabies vaccineA preliminary study. 15th National Conference of the
Association for Prevention and Control of Rabies in India,
Pune, 6-7 July 2013.
117. Manoj MJ, Chetan GK, Rao KVL, Venkatesh HN, Sibin
MK, Lavanya CH. The role of direct DNA repair gene O6methylguanine-DNA methyltransferase (MGMT) in high
grade malignant glioma. 39th Indian Society of Human
Genetics Annual Conference, Ahmedabad, 22-25 January
2014.
118. Mariamma Philip. Structural equation modelling
approach in handling missing data. 31st Annual Conference
of Indian Society for Medical Statistics, Christian Medical
College, Vellore, 24 -26 October 2013.
119. Masoom Abbas Kulkarni, Girish Baburao, Mustare
Veerendrakumar. Subcutaneous unfractionated heparin
followed by oral anticoagulation in deep cerebral venous
sinus thrombosis (dcvt). National Conference of Indian
Stroke Association-2014, Trivendrum, 14-16 March
2014.
120. Mathur S, Sharma MP, Bharath S. Effectiveness of
mindfulness based cognitive therapy for late life
depression. 40 th National Annual Conference of Indian
Association of Clinical Psychologists, SRM University,
Kattankulathur, Chennai, 28 February-2 March 2014.
121. Mathuranath PS. Epidemiology of dementia: current
status in India. 21st Annual Conference of the Indian
Academy of Neurology. Indore, 24-27 October 2013.
122. Maya Bhat. Demonstration of hemorrhage in the wall
of pyogenic abscess using susceptibility weighted
imaging. 16th Annual Conference of Indian Society of
Neuroradiology, Bangalore, 26- 29 September 2013.
123. Meeka Khanna. Prevalence of fatigue in patients with
Guillain Barre syndrome in neurological rehabilitation
setting. 8th Annual Conference of Indraprastha Association
of Rehabilitation Medicine - DELHI PMRCON 2014. New
Delhi, 1-2 March 2014.
124. Meena KS. Quality of life of persons with mental illness
staying in a psychiatric rehabilitation centre and home:
a comparative study. National Conference, Research
and services in Psychiatric Rehabilitation with focus on
Recovery. NIMHANS, Bangalore, 8-9 March 2014.
125. Megha Rupa. (i) Child development. Training of
Trainers on Child Protection organized by UNICEF in
collaboration with CCCYC, Bangalore, 8-13 February
2014 (ii) Development of videos: An innovative approach
to parent training. 40th National Annual Conference of
Indian Association of Clinical Psychologists, Chennai, 28
February-2 March 2014 (Best Paper Award)
126. Mehrotra S (i) Counseling skills. Life Skills Educators
Workshop on Empowering Adolescents training,
NIMHANS, Bangalore, 26-28 September, 2013, 1315 March 2014 (ii) Mental health promotion. In
Orientation to Clinical Psychology: Emerging areas
Seminar, NIMHANS, Bangalore, 3-4 December 2013
(iii) Encouraging volunteerism? In Recovery Oriented
Services for the mentally ill. National Conference on
Research and Services in Psychiatric Rehabilitation,
127. Mehrotra S, Tripathi R. Positive psychology: what?
how? where? National Workshop, Research Survey and
Exploration in Psychology (6th ICSSR Survey), NIMHANS,
Bangalore, 21 September 2013.
128. Modi Mehul Navin Chandra. Value of indocyanine green
dye videoangiography in intracranial aneurysm surgery – A
perspective from a tertiary medical centre in a developing
country. NEUROVASCON 2013, Cerebrovascular Society of
India. Hyderabad, September 2013. (Best Paper Award)
129. Mohd Afsar, Jamuna Rajeswaran. Neuropsychological
profile in juvenile onset Schizophrenia. 4th Continuing
Education
in
Neuropsychology-Neuropsychological
Rehabilitation-Emerging Hope: EEG NFT, NIMHANS,
Bangalore, 18-20 November 2013.
130. Mohit mittal. Stunned myocardium following triple HHH
therapy. ISNACC 2014, Jaipur, 31 January- 2 February 2014.
131. Nagarathna S. Central nervous system infection and its
laboratory diagnosis. National Conference on Driving
Stem Cell Research Towards Therapy a Vision of the
Future. 20-21 March 2014.
Annual Report
132. Nandakumar DN, Hurmath FK, Palaniswamy R. IL-1β
mediates migration and invasion of glioma cells in a p53independent manner. 33rd Annual Convention of Indian
Association for Cancer Research. Kollam, Kerala, 13-15
February 2014.
133. Nandakumar DN, Palaniswamy R. Anti-oxidant status
and activated NMDA receptors in glioma. 82nd Annual
Meeting of Society of Biological Chemists, India.
University of Hyderabad, 2-5 December 2013.
134. Nandakumar DN. Glutamate receptors and cytokines
in progression of primary brain tumour. National
symposium, Cancer Biology, Mysore, 29-30 November
2013.
135. Narasinga Rao KVL. Brain and Cognition. Short term
training program. Department of Medical Electronics,
BMS College of Engineering, Bangalore. 8 January 2013.
136. Narayana DH, Madhusudana SN, Sampath G, Tripathy
RM, Sudarshan MK. Safety and immunogenicity study of
a new purified chick embryo cell rabies vaccine vaxirab-n
(pitman moore strain) manufactured in India. 15th
National Conference of the Association for Prevention
and Control of Rabies in India, Pune, 6-7 July 2013.
137. Nathan D, Narasimha VL, Ravishankar V, Kumar CN,
Thirthalli J, Sivakumar PT, Bharath S, Mathew V,
Gangadhar BN. Electroconvulsive therapy in the elderly-a:
five year retrospective chart review. ECT Symposium,
NIMHANS, Bangalore, December 2013.
138. Nayak C, Sinha S, Nagappa M, Thennarasu K, Taly AB.
Relation of sleep related events & spontaneous arousals
during sleep in Juvenile Myoclonic Epilepsy patients
as compared to Normal Subjects. Colloquium in Drug
Resistant Epilepsy. Bangalore, 16 -18 August 2013.
139. Nesin M, Raju TR, Laxmi TR. Rotarod: motor behavioral
testing. APPICON 2013: Pre-conference Workshop,
Current Physiological Techniques from Basics to Applied
Aspects: Emerging trends in Neurophysiology from Cell
to System. NIMHANS, Bangalore, 26 November 2013.
140. Nirmala BP (i) Recovery-oriented services at NIMHANS:
Psychiatric social work services. Annual National
Conference of the World Association of Psychiatric
Rehabilitation, Calicut, Kerala, 20-21 July 2013 (ii)
Recovery oriented mental health services for women
2013-14
innovation from social work perspective. 32nd Annual
ISPSW, Karnataka State Women’s University, Bijapur,
20-22 January 2014 (iii) Family and Community
Responsibility in Placement of Persons with Intellectual
Disability. National Conference, Employment Leading to
Independent Living of Persons with Intellectual Disability,
NIMH Secunderabad, 25-27 February 2014 (iv) (a)Role of
families in the rehabilitation of psychiatrically disabled:
Medication adherence.(b) Team presentation on Recovery
Oriented Services in Psychiatric Rehabilitation services
ROSes Conference. 8-9 March 2014.
141. Nupur Pruthi (i) Making screw insertion in C2
vertebra safer: Clinical application of a novel CT based
grading system. 3rd Annual Conference of Karnataka
Neurosciences academy, Bangalore, 15-16 June 2013
(Best Paper Award) (ii) CV junction anomalies. 16th
Annual Conference of Indian Society of Neuroradiology,
Bangalore, 26-29 September 2013.
142. Padmanabhan B (i) BET family proteins as therapeutic
targets in major diseases. 42nd National Seminar
on Crystallography and International Workshop on
Application of X-ray Diffraction for Drug Discovery, New
Delhi, 21-23 November 2013 (ii) The Keap1-Nrf2 pathway:
A potential therapeutic target in neurodegenerative
diseases. 6th International Symposium on Recent Trends
in Macromolecular Structure and Function, Chennai, 2224 January 2014 (iii) Identification of BRD2 inhibitors
by structure-based drug design method. Colloquium on
Drug Resistant Epilepsy, Bangalore, 16-18 August 2013.
143. Padmavathi N. A study to assess tobacco use among adult
men. Indian Society of Psychiatric Nurses Conference. St.
John’s College of Nursing, Bangalore, February 2014.
144. Padmavathy D, Ragesh G. A brief skill-based gatekeeper
training program for suicide prevention. NIMRCPSYCON
2014. Second Joint Conference of the Department of
Psychiatry, NIMHANS, India & The Royal College of
Psychiatrists, UK, 7-8 March 2014.
145. Palaniswamy R, Hurmath Fathima K, Nandakumar DN.
NMDA receptor mediated proliferation and activation
of MMP-2 on glioma. 82nd Annual Meeting of Society of
Biological Chemists, India, University of Hyderabad, 2-5
December 2013.
146. Paramita B, Revathi S. Psychosocial consequences among
women survivors of Uttarakhand flood disaster. 32nd
Annual Report
2013-14
Parkinson’s disease. Parkinson’s disease Education
Program, Understanding parkinson’s disease: from
clinics to basics, NIMHANS, Bangalore, 5-7 March 2014.
Annual National Conference of ISPSW 2014, Bijapur, 22
January 2014.
147. Paramita Bhowmick. Empowerment of women in disaster
management. 32nd Annual National Conference of ISPSW
2014. Bijapur, Karnataka, 20-22 January 2014 (Best
Paper Award)
148. Paritosh Pandey (i) Surgery for ischemic cerebrovascular
diseases. Neurosurgery update, May 2013, Mumbai
(ii) Surgery for AVMs- an underutilized treatment,
Radiosurgery update. New Delhi, April 2013 (iii) Surgery
for ischemic cerebrovascular lesions. Cochin Neurological
Association, June 2013 (iv) Pediatric Moyamoya disease.
Annual Conference of Indian Society of Pediatric
Neurosurgery, Udaipur (v) Rational management of
intracranial avms: surgery, radiosurgery and embolization.
Annual Conference of Neuro Surgeons Society of India,
Rishikesh, February 2014 (vi) (a) STA_MCA bypass (b)
Carotid Endarterectomy (c) Surgery for Intracranial
AVMs. Annual Cerebrovascular update, Bangalore,
February, 2014 (vii) How I do it: Surgery for peritrigonal
AVMs. Dandy Society Meeting, Mahabalipuram, January
2014 (viii) Surgery for moyamoya disease. Annual
Conference of Indian Society of Cerebrovascular Surgery,
Hyderabad (ix) (a) Future research in traumatic brain
injuries: surgeon’s perspective (b) Geriatric head injuries.
First Annual AIIMS Neurotrauma Conference, New Delhi.
149. Patil SA, Sharma N, Sinha S, Satishchandra P. Antiheat shock protein -65 (HSP-65) antibodies in epilepsy.
Colloquium in Drug Resistant Epilepsy, Bangalore, 16-18
August 2013.
150. Paulomi MS, Singhal M, Sudhir PM, Manjula M.
Understanding and managing emotions. Workshop,
Making a Difference: A Workshop on Youth Mental
Health for College Counsellors. Department of Clinical
Psychology, NIMHANS, 11-12 July 2013.
151. Phalguni Anand Alladi. (i) Role of glia in amyotrophic
Lateral Sclerosis pathogenesis: to care for or create chaos?
21st Indian Academy of Neurosciences meet. Allahabad.
25-27 October 2013 (ii) Does the brain Age? Indian
acience Academies. Workshop, Sense and Sensibility,
Mumbai, 20-21 December 2013 (iii) Interaction and
advice to masters’ students of Neuroscience. INSA
sponsored Lecture. Mumbai, 20-21 December 2013
(iv) Neuroanatomical parallels between aging and
152. Pooja Shree Mishra, Dinesh K Dhull, Anu Mary Varghese,
Vijayalakshmi K, Sathyaprabha TN, Nalini A, Phalguni
Anand Alladi, Raju TR. Astroglial and microglial
responses in an experimental model of Sporadic
Amyotrophic Lateral Sclerosis. 31st Annual Conference of
Indian Academy of Neuroscience, October, 2013.
153. Prabha S Chandra (i) Prescribing dilemmas in pregnancy
and lactation. West Zone Annual Conference-2013,
Goa, 18-20 October 2013 (ii) Psychotropic Medications
in Pregnancy & Lactation. Neuropsychopharmacology
Update – 2014, 23 February 2014.
154. Prabhuraj AR. Specturm of Intracranial fungal masses –
NIMHANS experience. Annual Conference of Neurological
Society of India, Mumbai, 12-15 December 2013.
155. Pradeep Kumar Mishra, Bindu M Kutty, Laxmi TR. Early
maternal separation stress during stress hyporesponsive
period in rats affects both fear memory and fear extinction.
International Symposium on Neurosciences and 31st
Annual Conference of Indian Academy of Neurosciences
and Local Chapter of IAN, Allahabad, 25-27 October 2013.
156. Pradeep Kumar Mishra, Bindu M Kutty, Laxmi TR. Early
maternal separation during stress hyporesponsive period
evokes age-dependent changes in retention and extinction
of fear memory in male Wistar rats. 59th Annual Conference
of Association of Physiologists and Pharmacologists of
India. NIMHANS, Bangalore, 28-30 November 2013.
157. Pradeep Kumar Mishra, Preethi Hegde, Laxmi TR.
Neural correlates of fear memory and fear extinction:
Single and multi-unit recordings in freely moving rats.
APPICON 2013: Pre-Conference Workshop, Current
Physiological Techniques from Basics to Applied Aspects:
Emerging trends in Neurophysiology from Cell to System,
NIMHANS, Bangalore, 26 November 2013.
158. Pragyan Sharma. Subacute and Chronic subdural
hematomas in young populations less than 40 years. 22nd
Annual Conference of Neurotrauma Society of India,
Guwahati, 23-25 August 2013. (Awarded Shri Suresh
Kare Indoco Remedies, Best Poster 2nd Prize.)
(NSI – Neurosurgery award).
Annual Report
159. Prakasha LM. (i)Advanced Infection Imaging. RITE
2013, Sree Ramachandra Medical College, Chennai, 1415 November 2013 (ii) T2* Perfusion in tumors. Annual
CME Society of Indian Radiographers, Pondicherry, 2-3
October 2013.
160. Pramod Kumar Pal. Sleep disturbances in Huntington’s
disease. 21st Annual Conference of Indian Academy of
Neurology. Indore, Madhya Pradesh, 24-27 October
2013 (ii) Clinical case discussion on basal ganglia.
SHINE 2013, Chennai, 27 April 2013 (iii) (a) Diagnosis
of Parkinsonism: pearls & pitfalls, (b) DBS in Parkinson’s
Disease: Past, Present and Future. Update on Parkinson’s
Disease. Neuro-Club, Bhopal, 30 June 2013 (iv) Clinical
approach to tremor. 3rd Annual Conference of the
Karnataka Neurosciences Academy. NIMHANS. 16
June 2013 (v) Approach to Dystonia. Case Discussion
on Dystonia. IAN Summer School of Neurology 2013.
All India Institute of Medical Sciences, New Delhi, 1921 July, 2013 (vi)Parkinsonism plus syndromes. CME
of 69th Annual Conference of Association of Physicians
of India. Ludhiana, 20 February 2014 (vii) Psychogenic
movement

annual report 2013-2014

Transcription

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