N WSU equine veterinarians studying new treatments for navicular disease
Transcription
N WSU equine veterinarians studying new treatments for navicular disease
COLLEGE OF VETERINARY MEDICINE | WINTER 2008 | VOLUME 5, NUMBER 1 WSU equine veterinarians studying new treatments for navicular disease N “We have learned that navicular avicular disease, or inflammation disease is not one disease, but in fact of the heel, is one of the most many different problems that cause common causes of performancethe same clinical signs in horses,” she limiting lameness in the front legs of said. “We have learned that MRI is many different types of horses. Though it often necessary in making appropriate is common and veterinarians have long treatment decisions in many horses. recognized and treated it, the cause of It allows us to determine the source of navicular disease is poorly understood. inflammation and pain in more than 90 “A wide variety of treatments have percent of horses with pain that has been been used on horses with clinical signs of localized to the foot. navicular disease, which can be described “Although we still treat horses with as heel pain,” said Dr. Sarah Sampson, foot lameness without an MRI, our a Washington State University equine experience with it has taught us that we veterinarian with expertise in navicular greatly increase the chances of helping disease and magnetic resonance imaging. A horse having its foot examined for navicular disease in WSU’s MRI. horses return to performance once we “But most treatments have proven know the cause of the problem and can ineffective in stopping the chronic, apply an appropriate treatment,” Dr. Sampson said. “For example, a progressive degeneration that occurs in the navicular bone of affected horse with tendonitis of the deep flexor tendon may need to be treated horses. Many treated horses have repeated episodes of lameness that for tendonitis, not just navicular disease, which may have seemed eventually result in retirement if they are performance horses.” An important advancement in diagnostic technology is changing appropriate based on a radiograph alone. Many horses with clinical signs this scenario—the use of magnetic resonance imaging, or MRI. WSU’s of navicular disease need an MRI.” College of Veterinary Medicine pioneered the clinical use of MRI in live horses beginning in 1996. It is currently one of only a few New Treatments veterinary hospitals in the world equipped with this technology, and Because of the information learned from MRI evaluations of horses it has moved WSU to the forefront of veterinary medicine in the with navicular disease, new treatments are being developed and used. evaluation of lameness and neurological disorders. In recent years, veterinarians have evaluated many bone and soft tissue problems with MRI technology, many of which have not been diagnosed in live horses before. “MRI has allowed us to see tendons, ligaments, and bones in the horse’s foot in ways never before possible,” Dr. Sampson said. “The use of MRI to evaluate the feet of affected horses has been the biggest single step forward in understanding navicular disease in the past 50 years. Our eleven years of experience with MRI evaluations has taught us much about the disease. Continued on page 6 IN THIS ISSUE ■ Procedure reduces behavioral problems ■ WSU helps establish new horse association ■ WADDL tests for causes of equine abortion ■ 2008 WSU Equine Health Advisory Board members ■ New equine pain medication Equine News is published four times a year by Washington State University, PO Box 645910, Pullman, Washington 99164-5910. Volume 5, Number 1. To subscribe, contact Emmy Widman at [email protected] or 509-335-3100. 2/08 121755 Equine NEWS Laparoscopic procedure reduces problem behaviors in mules and mares L acey is beautiful, full of personality, and very athletic—for a mule that is. Her owners plan on showing their cherished mule when she is ready, but they face an obstacle that all owners of female mules or mares go through—heat cycles. A female mule, or “molly,” in estrus (otherwise known as heat) can make working, showing, or competing more difficult. Mules can compete in many of the same sports as horses, such as cutting, roping, or dressage. But both mares and mules experience frequent heat cycles through the spring and summer, also the season for competitive equine sports. These cycles may cause mollies to misbehave, lack focus, or become uninterested in what their owner wants them to do. They may also urinate frequently, open and close their mouth frequently, posture with their tail out, seek more attention, and may instigate injuries while attempting to socialize with their male counterparts within a herd or across fences. Mares may also display undesirable behavior while in heat, such as kicking or biting. That is why Lacey’s owners, Suzy and Eddie Epler of St. Maries, Idaho, decided to have her undergo a laparoscopic ovariectomy, a technically advanced and minimally invasive surgery to remove her ovaries. “You can’t breed a mule and we wanted to get rid of the heat cycles,” Suzy Epler said. “She is our pride and joy and we want to keep her for a lifetime.” The Eplers heard about the procedure from their local veterinarian, Dr. Doug Walker, and that it is offered at the WSU College of Veterinary Medicine. “Male mules and horses are often castrated to improve their behavior as performance animals and as pets in general,” said Dr. Claude Ragle, a WSU associate professor and boardcertified equine surgeon. “In females, an ovariectomy operation can accomplish the same goal, but it is an option often overlooked.” “Young mollies are the ideal candidate for an ovariectomy because they are sterile and can’t reproduce,” Dr. Ragle said. “In the past, there wasn’t a good technique to remove ovaries in female mules and horses. With laparoscopy, now there is a safe method.” In fact, laparoscopic ovariectomy is a method Dr. Ragle helped pioneer as one of the first veterinarians to adapt laparoscopy to clinical practice and develop useful procedures. Laparoscopy has emerged in veterinary medicine over the past decade as a type of minimally invasive surgery that allows for a faster recovery, less scarring, and less pain. Dr. Ragle’s interest in laparoscopy was initially spawned in the late 1980s when he was looking for a better way to perform ovariectomies in horses and mules. Since then, he has performed the procedure on hundreds of mares and mules, and has been called on to teach the technique all over the United States and abroad. Being minimally invasive, the procedure can be done on a standing horse with local anesthetic blocks, rather than completely sedating a horse with general anesthesia. And because the incisions made are so small, many horses are able to return to athletic usefulness much faster than if traditional surgery had been performed. Eddie Epler pats Lacey, his favorite mule. In addition, the WSU Veterinary Teaching Hospital now utilizes the most advanced electrosurgical instrument available, called a LigaSure™, which seals blood vessels during laparoscopic surgery. This instrument allows ovariectomies to be performed faster and better. “The LigaSure™ transects the ovary free without loss of blood or the use of staples or sutures,” Dr. Ragle said. “This procedure is fairly new to the horse and mule world, so not that many people know about laparoscopic ovariectomy as an option and its potential benefits. Not only does it suppress the clinical signs of estrus behavior, making mollies or mares generally easier to train, it also reduces the chance of unwanted horses from indiscriminate over-breeding or those with genetic disorders. It is also an over-looked way for breeders to conserve valuable genetics by selling spayed, as opposed to fertile, mares. In addition, the equine ovary is not crucial to bone metabolism like in humans, so there is no need to worry about estrogen replacement because their bones are not affected,” he said. Currently, Dr. Ragle and WSU board-certified equine surgeons Dr. Kelly Farnsworth and Dr. Julie Cary perform laparoscopic ovariectomies at the WSU Veterinary Teaching Hospital. The standing procedure currently costs about $1,500 in average cases, which is very costeffective compared to the expense and efforts involved with long-term hormone therapy to suppress estrus in the equine. Horses and mules that undergo the procedure are held off feed or are put on a low-bulk diet a few days before the surgery. The surgery itself lasts about one hour, and the horse or mule is allowed to go home within a day or two after the procedure. The incisions take approximately two weeks to heal, and the animal typically can go back to work within three to four weeks. “Lacey had the surgery before her first heat, and she recovered really well,” Suzy Epler said. “It was actually really easy on her.” “For owners considering an ovariectomy, we like to see the animal when it is young, as soon as it is trained enough to stand in a stock for surgery,” Dr. Ragle said. “There are a lot of mule owners that think females are nicer and less pushy than males, but don’t like them coming into heat. An ovariectomy may be an ideal option for them.” For more information about laparoscopy, ovariectomies, or to schedule an appointment, contact the WSU Veterinary Teaching Hospital or Dr. Claude Ragle at 509-335-0711 or [email protected]. 2 Winter 2008 WSU helps establish new horse association in North America W hat do you get when you cross a thoroughbred with an Arabian horse? An Anglo-Arabian, technically. To Harriet Aiken, a northern Idaho horse breeder, you get an amazingly athletic and comfortable horse. “From the thoroughbred, you get speed and substance: a long neck, more prominent withers and a longer hip than a purebred Arabian,” she said. “From the Arabian side, you get intelligence and endurance with stronger legs and feet. The result is a horse that is not as heavy Jenny Freeling, a third-year WSU veterinary student, with Marrakech, one on the forequarters as a thoroughbred, but more of Aiken’s Anglo-Arabians. Freeling is an apprentice at Aiken’s Greenbriar forward into the bridle than an Arabian, a back and Farm, learning to train and competitively ride horses. withers shaped for a good saddle fit, and a stride length that should produce a comfortable ride. At first, his connections in Abu Dhabi helped Aiken identify That is what makes this breed stand out.” the right Arabian stallion to purchase, and then he facilitated the Aiken is hoping she can help make the breed artificial insemination of one of her mares. Seven years and 12 Anglostand out as well. Recently, she and two other horse Arabian horses later, Aiken has been very pleased with the results. “I Dr. Ahmed enthusiasts in the United States established the could not have done this without the expertise and friendship of Dr. Tibary North American Anglo-Arabian Horse Association. Tibary. I could not have even gotten started,” she said. Aiken has been involved in competitive endurance riding for But their collaboration did not stop there. Dr. Tibary also nearly three decades, representing the United States in a number of introduced Aiken to members of the European and North African international competitions in various capacities. Though endurance Anglo-Arabian community, which brought her to Spain this competition is dominated by Arabians, Aiken past spring for a meeting hosted by the was looking for something different. While international Anglo-Arabian association. “There competing, she began to take note of Angloare 14 countries involved in the international Arabians due to their comfort and speed. association, and they really wanted the United Many European countries have accepted States to become involved,” Aiken said. Anglo-Arabians as a recognized breed for When she got home, she did some centuries, and there is an international research online and found two other women association for Anglo-Arabians, but in North with interests in the breed—one in Maryland America the breed is practically non-existent. and one in Florida. Together, they made the “I wanted one to ride, but in the United States, decision to become the three officials needed they are hard to find,” she said. “So I thought I to start the nonprofit North American Anglocould breed them.” Arabian Horse Association. And so she did, but not without the help “By working with the Arabian Horse of Dr. Ahmed Tibary, WSU’s renowned large Association registry, we hope to showcase the animal reproduction specialist and head of unique qualities of Anglo-Arabians,” Aiken said. the large animal theriogenology program “We are working on setting up an award system at the WSU College of Veterinary Medicine. to recognize this breed in sporting events such Not only was he a short drive from her ranch Aiken’s Calcutta (“Cutter”), a three-year-old as endurance riding, eventing, and for those outside of Troy, Idaho, but Dr. Tibary was also competing in Arabian youth shows and Arabian Anglo-Arabian gelding. very familiar with Anglo-Arabians due to his sport horse shows. background in his native Morocco. “Right now, we don’t know how many “This is what my family used to breed, and I have also worked breeders there are in the United States,” she said. “We want to reach with some of the largest Arabian stud farms in the world, including out and find breeders, riders, owners, and anyone interested in the Royal Stables in Morocco and the Amiri Stables in Abu Dhabi,” Anglo-Arabians and bring them together.” Dr. Tibary said. I Count Me In t is our privilege and desire at WSU to provide the best veterinary care to the many formidable equine athletes and companions who are treated at our hospital. Through the generosity of many individuals who support quality health care and the WSU College of Veterinary Medicine’s mission of teaching, research, and service, we are able to continue our work and plan for the future with confidence. The largest part of what we do is made possible by the encouragement, collaboration, and financial contributions of our generous public. Through each thoughtful gift, WSU is making a difference in the lives of our students and the equine industries of Washington and the region. These gifts enable us to greatly enhance the scope of our equine veterinary services and allow us to continue to provide world-class health care for horses throughout the Pacific Northwest. We would be honored if you would choose to become a partner in the important work that goes on here. If you are interested in supporting the advancement of Washington State University’s renowned equine medicine and surgery section, please contact Dr. Richard DeBowes, DVM, associate dean of veterinary development, at 509-595-8015 or [email protected], or Lynne Haley, director of veterinary development, at 509-335-5021 or [email protected]. 3 Equine NEWS WADDL offers testing to discover causes of equine abortions W hen a mare aborts a foal, it can be a traumatic event for both horse and owner. While emotionally and financially expensive, it is not terribly uncommon in the equine breeding business. As many as 30 percent of broodmares fail to produce a live foal. Equine abortion describes the loss of a fetus before it is viable— between 50 to 300 days of pregnancy. Before then, it is considered an early pregnancy loss, with the embryo reabsorbed in the mare’s body. After 300 days, the foal is considered stillborn because many foals born alive at that point are able to survive. When an abortion occurs, it is important to find the cause. Some conditions that lead to abortion occur sporadically and involve a single mare. Other conditions are infectious and contagious, which can cause an outbreak of abortions in mares in a particular area. Common causes of abortion related to an individual mare include conformation problems involving the vulva, cervix, or vaginal canal. Conformation problems can allow bacteria to enter the uterus, causing infections like placentitis (inflammation of the placenta). Other problems include abnormalities with the placenta or umbilical cord, and twinning. While twin foals may be an exciting prospect, caution is warranted because twinning is the most common non-infectious cause of abortion in mares, and usually occurs early on or after the sixth month of pregnancy. Infectious causes of abortions include viral infections like equine herpes virus (EHV-1) and viral arteritis (EVA), as well as fungal or bacterial infections such as Streptococcus equi, E. coli, and leptospirosis. In addition to twining and umbilical cord defects, congenital defects of the foal and some trace mineral deficiencies are other potential causes. Abortion may also occur after severe illness, colic, or surgery. Signs that a mare is about to abort include mammary gland development and lactation or “bagging up,” stretching of the vulva, increased vaginal discharge, overt abdominal edema, or if the mare displays symptoms of mild colic. If these signs occur in mid to late pregnancy, a veterinarian should be contacted immediately. If an abortion does occur, samples of the fetus, placenta, and blood from the mare can be sent to the Washington Animal Disease Diagnostic Laboratory (WADDL) in Pullman for a diagnosis. “The tissue samples must be obtained fresh from the placenta and fetus within the first 24 hours after an abortion occurs from the mare, but the earlier the better,” said Dr. Ahmed Tibary, WSU associate professor and board-certified theriogenologist (reproduction specialist). “There are some conditions we can prevent, and some that we can’t, but the cause should be determined. “To get a precise diagnosis, samples must be submitted to WADDL correctly and in good condition,” he said. “The WADDL Web site (www.vetmed.wsu.edu/depts_waddl) includes a form that describes what tissues should be collected and how to submit them. A veterinarian should always be contacted to help with this, and to check the mare to make sure she expelled the entire placenta and that she is recovering.” With a diagnosis, owners are in a position to make decisions about whether to breed their mare again and to prevent other abortions from happening to other mares in their herd or the local region. “Viral causes can be managed with proper biosecurity measures and vaccinations. Vaccination is important because infected mares can easily infect other mares,” Dr. Tibary said. Biosecurity measures help prevent outbreaks by isolating mares with an infectious disease and practicing good sanitation while caring for sick mares. Other non-infectious conditions that lead to abortion may also be correctable through medical means or through frequent pregnancy evaluations for mares that are deemed high risk. “Those with bacterial infections that cause placentitis can be managed medically if the infection is detected early,” Dr. Tibary said. “There are also surgical procedures to help prevent ascendant infections in mares with vulvar/vaginal conformation problems.” For more information about submitting samples, contact the Washington Animal Disease Diagnostic Laboratory at 509-3359696 or www.vetmed.wsu.edu/depts_waddl. For more information about equine pregnancy issues or managing a mare with a high-risk pregnancy, contact the Equine Medicine or Equine Theriogenology service at the WSU Veterinary Teaching Hospital at 509-335-0711. WSU Veterinary Teaching Hospital Switchboard Main Hospital Switchboard and Emergencies:.................509-335-0711 Equine Appointments.....................................................509-335-0711 Agricultural Animal Appointments (Non-Theriogenology).................................................509-335-5377 Theriogenology (Equine and Ag Animal).........................509-335-0741 Small Animal Appointments.................... 509-335-0751/509-335-0752 Dean’s Office..................................................................509-335-9515 Department Chair...........................................................509-335-0738 VTH Fax Number............................................................509-335-3330 Billing.............................................................................509-335-0711 Pharmacy.......................................................................509-335-0736 Pet Partnership Program.................................................509-335-4569 Pet Loss Hotline..............................................................509-335-5704 WADDL; Diagnostic Lab..................................................509-335-9696 Want to know more about our equine clinical services, research, and accomplishments, or receive our quarterly newsletter online? To subscribe to the online newsletter, go to www.vetmed.wsu. edu/depts-vth/EquineNews/online.aspx. Check out our equine Web site at www.vetmed.wsu.edu/ depts-equine, or the WSU Veterinary Teaching Hospital Web site at www.vetmed.wsu.edu/depts-vth/equineServices.aspx. Also feel free to call 509-335-0711 for equine appointments or emergency care. 4 Winter 2008 Your 2008 WSU Equine Health Advisory Board Members T Jeff Anthony is an investment banker and lifelong horse enthusiast whose family has been involved with saddlebred, cutting, and hunter/jumper horses in Washington state for more than three generations. He and his wife own and manage Potcreek Meadow Farm, an equestrian boarding and training facility located in Redmond, Washington. Anthony can be reached at 206-669-3440 or [email protected]. he WSU Equine Health Advisory Board is a volunteer leadership committee with equine interests from around the Northwest. The volunteers’ role is to advise the WSU College of Veterinary Medicine’s equine section about industry needs, health studies, and other issues of importance that affect horses and their owners, including long-term fundraising. As valued advocates and advisors to WSU’s equine program, the group works to promote and advance shared interests in equine health care service and research programs. These programs are significant contributors to horse health throughout the region, nation, and world. Because the board is enthusiastic about communicating with horse owners, they are featured in this issue. We invite readers to contact them with any questions, ideas, or suggestions you may have. You are also welcome to contact Dr. Richard DeBowes, associate dean of veterinary development and external relations, at 509-595-8015 or [email protected]. Dr. Richard (Dick) Vetter and Kathy, his wife and technician, have a mobile equine veterinary dental practice, Performance Equine Dentistry Inc. P.S. Their practice covers routine preventative dental care to periodontal and restorative work. The Vetters can be contacted at 360-245-3476, [email protected], or www.perfequinedentistry.com. Linda Sferra chairs the Equine Health Advisory Board. She is a life-long horse enthusiast, with interests in racing, foxhunting, and trail riding, and she competes on the Northwest hunter/jumper circuit. Located on Vashon Island, Washington, Sferra can be reached at 206-4637263 or [email protected]. Dr. Susan Bernard is a semi-retired veterinarian and owns a small animal practice in western Washington. She also practiced at a private equine veterinary practice in Woodinville, Washington, for many years. She is a lifelong horsewoman, and passionately competes in equestrian show jumping in the adult amateur jumpers division. Located in Monroe, Washington, Dr. Bernard can be contacted at [email protected]. Ron Palelek has more than 40 years of experience in the management, care, breeding, training, and showing of Arabian and half-Arabian horses. He has owned and operated Vantage Point Farm II Ltd. since 1964 in Cheney, Washington. He is also an international judge for the South African and Australian national championship horse shows, and judges several horse shows in the United States as well. Palelek can be reached at 509-456-4057 or [email protected]. Laura Allen and her husband previously owned and operated Mills Horse and Tack in Bellevue, a supplier for English style riders. Allen is an experienced rider in both Western and English styles, and competes in Circuit A dressage shows. Located in Woodinville, Washington, Allen can be reached at 206-499-2943 or [email protected]. Debbie Pabst, along with her husband Rick, owns and operates Blue Ribbon Farm, a thoroughbred market breeder business in which they sell yearlings for racing. Pabst has worked with horses for more than 30 years and is a member of the board of directors for the Washington Thoroughbred Association (WTBA). Located in Buckley, Washington, Pabst can be reached at 253-862-9076 or [email protected]. Andrea Lorig is the newest member of the WSU Equine Health Advisory Board. She owns Park Place Farm, a horse boarding facility in Kirkland, Washington, in Bridle Trails State Park. She is a life-long horse enthusiast and for years has taught riding lessons and managed stables and horse clubs. She has served on the Lake Washington Saddle Club Board, as a founding trustee of the Bridle Trails Park Foundation, and as secretary of the Woodbrook Hunt Club of Tacoma for the many years. She also maintains memberships in the Masters of Foxhounds of America and Foxhound Associations. “My commitment to the WSU veterinary program has grown courtesy of the four horses I have sent to the college for diagnostic work in recent years,” Lorig said. “A mountain range may separate us, but I’ve always felt in close, immediate contact with the WSU staff caring for my creatures. It is a wonderful program and I plan to support it in every way I can.” Located on Mercer Island, Washington, Lorig can be reached at 206-232-4118 or [email protected]. Ed Armstrong is a life-long horse enthusiast and horse industry lobbyist in Washington state. He also chairs the Ride for Research Benefit to support WSU. Located in Olympia, Washington, Armstrong can be reached at 360352-5883. Dick Monahan is an attorney and horseman who has been involved with quarterhorse racing for more than 30 years. For 20 years, he has served on the national board of the American Quarter Horse Association, including as the association’s chair of the racing committee and the racing council, which oversees quarterhorse racing worldwide. Monahan can be reached at 509-529-5700 or dmonahan@ roach-monahan.com. 5 Veterinary Teaching Hospital Department of Veterinary Clinical Sciences College of Veterinary Medicine PO Box 646610 Pullman, WA 99164-6610 New equine pain medication offers fewer side effects D uring the past year, a new pain medication for horses called Equioxx® has become available through veterinary prescription. It is a non-steroidal anti-inflammatory drug for oral use in horses only. “Equioxx is in the same category of drug as ButeTM or BanamineTM, the most common pain-relieving medications for colic or pain,” said Dr. Debra Sellon, a WSU professor and board-certified equine medicine specialist. “Its advantage is that it seems to give the same pain relief as the others with fewer side effects. If Bute or Banamine is given at high doses, or for a long period of time, or to a sensitive horse, stomach ulcers or kidney damage may occur,” she said. “The risk for Equioxx seems to be a lot less.” Equioxx is marketed by Merial Limited and is available in an oral paste formulation for use once a day in adult horses. “It is approved for treatment of osteoarthritis in horses, but can be used for other painful conditions as well,” Dr. Sellon said. “Studies on the drug have only been done on adult horses at this point, but it may be indicated for use in foals in the future. For those that are concerned about potential side effects of other pain medications for their horse, talk to a veterinarian to see if Equioxx would be an option.” For more information, contact the WSU Veterinary Teaching Hospital at 509-335-0711 or Dr. Sellon at [email protected]. Continued from the cover funding to provide free MRI evaluations on at least 100 “Now that we are recognizing other locations of Horses that qualify horses,” Dr. Sampson said. damage in the horse’s foot, new treatments are being for navicular studies Horses involved in the studies can be any sex developed for specific problems,” Dr. Sampson said. will receive lameness or breed, but must be four years of age or older, and “These treatments need to be adequately evaluated workup and MRI at cannot be pregnant, lactating, or have systemic disease. before they can be recommended for routine use in no cost to the client. They must also have clinical signs typical of horses with performance horses.” navicular disease and have radiographs of their front Two studies are currently being conducted at WSU feet without defects on the flexor cortex. on two new treatments for horses with navicular “Horses that meet these criteria will receive an MRI disease. The first study involves assessing and treating evaluation on the front feet at no charge to the owner, once their clinical affected horses with a new therapeutic drug for those that have navicular findings are confirmed at an appointment at WSU,” Dr. Sampson said. disease with bone edema, and the second involves a surgical procedure to Owners that receive a free MRI must agree to participate in the help horses that have affected ligaments in the navicular region. drug treatment study if their horse meets the criteria based on the Dr. Sampson is a key researcher on the project along with Dr. Robert MRI findings. “If a horse received a free MRI, but the evaluation Schneider, a WSU professor and board-certified equine surgeon. Another showed it would not fit into either study, the owner would get all the member of the team is WSU equine intern Dr. Chad Marsh, who was information from the diagnostic evaluation at no cost, and the horse would then be treated like any other patient,” she said. “If the horse qualified for the study in which drug treatment is provided, all costs are covered by the study.” For horse owners who would like to become involved in the studies, or for more information, contact the WSU Veterinary Teaching Hospital at 509-335-0711 or Dr. Sarah Sampson at [email protected]. brought on staff specifically for these studies. The American Quarter Horse Association has partially funded one of the studies. Free MRI evaluations Here’s where the public can also help. The studies will be conducted for approximately one year on at least 100 horses. Horses with clinical signs of navicular disease are needed for the studies. “MRI is essential to select horses for these studies, and because of our support, we have 6