M V

MVM VERSION V
MVM is a comprehensive, specially
balanced, multiple vitamin and
mineral formula, with added
ingredients, designed to promote
body composition and athletic
performance.
MVM – Advanced Evidence Based Formulation
MVM is the most complete multiple vitamin and mineral supplement on the market for
anyone and especially for those who are interested in health, weight loss, body
composition and athletic performance.
While the general medical consensus for the general population over the years was that
you could get all you needed from food, that has changed – see the recent article “The
Bottom Line” from the Harvard School of Public Health at Harvard Article.
The use of MVM is even more important for those who exercise, as we’ll point out below.
Formulated by Mauro Di Pasquale, M.D.
Dr. Di Pasquale is a medical doctor, an author, a
former world champion in Powerlifting, a former
professor at the University of Toronto, and
actively involved in the sports and fitness fields
for over four decades.
Highest Quality at a Reasonable Price
The list price of MVM doesn’t reflect the high quality and quantity of ingredients in MVM or
the precision and care taken in its production. MVM is manufactured in a pharmaceutical
grade facility that follows good manufacturing practices.
MVM is of such high quality that contamination with impurities is negligible since it’s as low
as is commercially possible and definitely lower than most of our food supply, and
contamination with ingredients not on the label is zero (something of concern to drug
tested athletes). We make sure of that by running GC/MS analysis of each batch to ensure
its quality and purity.
Couple that with the cutting edge evidence based formulation and it’s easy to see that
MVM is a product that is of unparalleled quality and effectiveness, and guaranteed to have
in it what’s on the label, and nothing else.
All the Important Ingredients and Much More
MVM contains all the vitamins and minerals deemed important for optimal health, and at
levels that provide beneficial effects above and beyond amounts needed to deal with any
frank and marginal deficiencies that may be present.
With its evidence-based approach, meaning that there are valid scientific and
medical reasons behind the use of each of the ingredients in MVM, MVM is a
supplement that caters to everyone in our modern day society, including the special
needs of those looking to lose weight and body fat, and those involved in fitness,
exercise, and athletic competition.
Besides the full complement of vitamins and minerals MVM also contains several nutrients
that are felt to improve metabolism, decrease stress, and have anti-cancer and anti-aging
properties (see table below).
MVM and Athletes
MVM is designed not only to safeguard overall health, but also to provide for the special
needs that the athlete has for body maintenance, recuperation and repair. MVM supplies
all the basic nutrients that may be depleted in those who exercise and is formulated to
enhance the effects of training on body composition and performance.
MVM is so complete that you don’t have to worry if you
miss some of your other performance vitamins once in a
while because MVM will take up the slack in the short
term.
For example, MVM contains high doses of Folic acid,
Vitamin B6, Betaine and methylcobalamin, the
biologically active form of B12 (not the cyanocobalamin,
the synthetic and not as metabolically active form of B12
that is generally used), and increases energy and health.
There are supplements
that cost more,
including the various
pak ones that spread
their ingredients over
several tablets in a
marketing ploy to make
them out to be more
than what they really
are, but there’s none on
the market that’s better
than MVM.
This group of ingredients has important effects on macronutrient metabolism, energy
systems, and on combating the adverse effects of pollution and mercury toxicity. The
health effects of all four of these ingredients have been extensively documented. Several
of the medical parameters, such as homocysteine, cholesterol and C-Reactive Protein,
markers of heart disease and inflammation in the body, are decreased by their use and by
some of the other ingredients in MVM including the extensive number of antioxidants.
MVM is formulated to be the best vitamin mineral complex on the market regardless of
price, and is especially useful for anyone who diets and/or exercises. Athletes who are
concerned about body composition and performance will find MVM is ideally suited for
them and the ingredients in MVM will help support their training and diet efforts.
For example many preparations don’t contain iron even in low levels. However, iron is
important for many at least in minimal replacement doses, as in MVM, since it’s an
important part of daily supplementation for who exercise. 1
Also many preparations include beta carotene (as does MVM) but not vitamin A, assuming
that any vitamin A that is needed by the body (for many functions including maximizing
testosterone production and increasing insulin sensitivity) will come from the endogenous
conversion of beta carotene to vitamin A. This is not necessarily the case. As such MVM
contains 2000 IU of vitamin A and 10,000 IU of beta carotene – just to cover all the bases
(see sidebar for more info).
MVM contains 400 IU of vitamin E, a level that I feel is necessary for athletes. Many of the
other products, mainly because of expense contain about half that dose.
Athletes need high doses of the B vitamins, and again MVM has more than most
preparations containing 100 mg of B3 and 50 mg of the rest.
Besides hefty doses of the all the necessary usual vitamins and minerals, in the most
bioavailable forms, MVM contains a lot more ingredients to round out the formula and give
you everything you could possibly need as a foundation for maximizing health, body
composition and performance.
For example, MVM contains carnosine (a buffering agent and antioxidant that is implicated
in both the muscle fibers that hypertrophy with resistance exercise and exercise
performance, taurine, glutamine peptides, etc. that are targeted for athletes for improving
muscle mass, strength and performance and maximizing body composition.
Recovery and repair of tissues require a host of vitamins and minerals that participate in
synthesis of new cells and tissue, and providing these in supplement form can increase
health and decrease disease.
For example, the body needs certain vitamins and minerals to make compounds that fight
inflammation in the body, including Vitamin B6, Vitamin E, Vitamin C, niacin, zinc,
selenium and magnesium. Many vitamins and minerals also serve as antioxidants and
help protect cells against the oxidative damage produced by inflammation. This can be
seen in the beneficial effects of various individual vitamins and minerals in MVM, and in
the synergistic effects seen among some of these nutrients.
Vitamin B12 - The most expensive B vitamin in any product is vitamin
B12. MVM has several times as much Vitamin B12 as most preparations.
The usual form of vitamin B12 is called cyanacobalamin, a cheaper and
synthetic form of B12. Cyanacobalamin is changed into the body to the
active form of cobalamin in a reaction that strips off the cyanide
molecule In MVM I use 500 mcg of the much more expensive
metabolically active methycobalamin.
Vitamin A and Beta Carotene - As far as vitamin A there are a lot of
misconceptions about its functions, metabolism and toxicity, and about
the role of carotenoids.
Vitamin A is much more metabolically active than most people believe.
Besides the common knowledge that it’s involved in eyesight, it also
important for proper immune, gastrointestinal, musculoskeletal, and
hormonal functioning, and for the utilization of protein. For example
adequate body levels of vitamin A are important for testicular, ovarian,
pituitary, and adrenal function, and for the production of testosterone
and growth factors.1
Increased levels of vitamin A are necessary under conditions that
deplete vitamin A reserves, such as high protein diets and chronic
physically demanding exercise (as seen in any elite athlete), and any
polymorphisms that affect the absorption, metabolism and utilization of
vitamin A. There is also deficient intake in our society in those who diet
to lose weight, minimize body fat, and maximize body composition.
The vitamin A issue is often misunderstood and while subclinical and
clinical toxicities do occur, they’re not all that common even at
therapeutic levels. Although vitamin A can cause liver damage but this
damage typically occurs with daily doses of at least 25,000 units a day
for a prolonged period of time.
Beta carotene has two roles in the body. It is a potent antioxidant and
has beneficial effects on the immune system. As well, it can be
converted into vitamin A if there is a marginal or frank deficiency of
vitamin A.
Beta-carotene’s conversion to vitamin A in the body is limited by a
feedback system. Supplementing the diet with beta-carotene does not
produce any vitamin A toxicity despite its use in very high doses since
it’s only metabolized to vitamin A as needed. With adequate levels of
vitamin A in the system the feedback mechanism markedly decreases
the already poor transformation of beta carotene into vitamin A, with the
decrease being proportional to body levels of vitamin A.
MVM version V
Version V of MVM represents the ongoing improvement over more than a
decade (Version I was formulated in 1997) of the best multiple vitamin and
mineral supplement available anywhere.
As well as a full array of vitamins and minerals that surpasses any of the
other multis, MVM also contains a variety of ingredients meant to enhance its
effects on health, longevity, body composition and performance.
In keeping with the aim of maximizing health and meeting the needs of those
who exercise and who are looking to improve body composition, the
formulation for MVM has been improved, with more of some of the
ingredients, such as vitamin D, folic acid, iodine, chromium, and over a few
dozen new ingredients, including vitamin K, Digezyme, Bioperine, and a
dozen or so ingredients, such as various plant extracts, and several that
positively impact on health and metabolism.
Vitamin D
For example, vitamin D has been increased from 400 IU to 800 IU since it’s
been shown we need more vitamin D than was once thought and that
marginal deficiencies of vitamin D are common.
Vitamin D along with Calcium is intimately involved in skeletal homeostasis.
But each does much more. Vitamin D has several vital functions outside this
established role. Vitamin D has been shown to have important implications for
general health, immunity, and cognitive function. 2, 3, 4, 5, 6,
As important for the athlete vitamin D is intimately involved in body
composition, athletic performance, and risk of injury. 7, 8
For more information on vitamin D see the first issue of my Elite Performance
Newsletter at www.ElitePerformanceNewsletter.com.
Iodine, an important ingredient in the proper functioning of thyroid hormone
has been increased to almost double the level in the previous version of
MVM.
Vitamin K (as phytonadione) has been added as it’s been shown to
maintain normal blood coagulation, decrease bone loss, maintain bone
strength, and improve vascular health . It also may have roles in
mitochondrial electron transport, protein synthesis, neuroprotection and
immunity.
Digezyme™, an advanced plant enzyme complex, and Bioperine have also
been added. Bioperine (an extract from piper nigrum, which increases
nutrient absorption), and Digezyme ensures optimal absorption of the
supplement ingredients as well as helping food digestion and assimilation.
MVM also contains several groups of ingredients not found in most
multiple vitamin and mineral preparations. These ingredients add to the
effectiveness of MVM, making it the most complete multiple vitamin and
mineral formula on the market today, regardless of price.
Peptides and Amino Acids such as:
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Carnosine
Glutamine Peptides
L-Glutamic Acid
L-Lysine
N-Acetly-L-Cysteine
Taurine
Herbal and Plant Ingredients and Extracts
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Astralagus Root
Ginkgo Biloba Extract
Ginseng
Grape Seed Extract
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Milk Thistle Extract
Panax Ginseng
Pine Bark Extract
Schizandra Berry Extracti
Silymarin
Spirulina
Special Ingredients for improving health and metabolism
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Betaine
Choline Bitartrate
Citrus Bioflavonoids Complex
Coenzyme Q10
Fiber (both soluble and insoluble)
Hesperidin
Inositol
Lactobacillus Acidophilus
Lecithin
Lutein
Phosphatidylcholine
Rutin
Digestive and Absorption Aids
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Bioperine® {Black Pepper Extract (Piper Nigrum)
DigeZyme™ (Aspergillus Oryzae)
MVM version V Supplement Panel
http://www.mdplusstore.com
Exercise is Stress – How to Deal With It
No matter how you look at it, exercise is stressful to the body at the time exercise is done.
But while it’s tough on the body, exercise is usually good for you in the longer term.
More importantly for the elite power and endurance athlete exercise is necessary for
improving body composition and performance regardless of the sport, whether it be
bodybuilding, where the concern is in maximizing body composition and muscle mass, or
ultra-endurance sports where the emphasis is on performance.
During exercise the body copes with the wear and tear that exercise causes. There’s a
dramatic increase in inflammation and in catabolism particularly in the musculoskeletal
system. This is evidenced by the in catabolic pro-inflammatory cytokines such as
Interleukins 1 and 6 (IL-1 and IL-6) and tumor necrosis factor alpha (TNF-alpha). I believe
that in response to the inflammatory and catabolic changes there is a simultaneous
increase in GH and IGF-1 and the endogenous anti-oxidant system.
After the trauma of exercise the body goes in repair, recover, and if the recovery is
handled properly, super-compensation mode.
Elite power and endurance athletes who train hard and subject their bodies to what can be
considered extreme stress need to look at both the exercise and post exercise phases in
order to benefit from exercise as far as incrementally improving body composition and
performance there is a need to intervene both during and after exercise.
During exercise
in order to need to decrease the pro-inflammatory cytokines, increase the damaging
effects of the excessive amounts of free radicals produced during exercise.
This is the main reason that athletes who train hard need to use antioxidants to help
bolster endogenous antioxidant system. The use of antioxidants, in those that train hard,
doesn’t compromise the endogenous antioxidant system but rather complements it so that
counter productive excessive damage especially to membranes, mitochondria and genetic
material, doesn’t occur.
And this is also the reason why I put elite athletes on Antiox as part of their foundation
supplement regimen. And it’s also why I stress all three foundation supplements as a
foundation for their athletic success. 9
Laying the Foundation for Success
Antiox, along with MVM, and EFA+ make up the Foundation
Supplements.
These three lay the foundation for success in improving body composition and
performance.
Introduction
Increasingly over the past few decades research is showing that supplementing your diet
with vitamins, minerals, antioxidants, essential fatty acids and other ingredients can keep
you out of harms way, help deal with certain diseases, provide a foundation for optimal
health, and improve mental and physical performance.
10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
, , , , , , , , , , , , , , , , , ,
Some of these effects are due to correcting frank and marginal deficiencies while others
are due to the beneficial effects of the nutrients themselves at higher than recommended
daily intake.
Low intakes of various nutrients can lead to marginal deficiencies. Low intake is a problem
in a significant proportion of athletes, especially those watching weight and body
composition and thus do not consume sufficient amounts of many nutrients from foods
alone. These deficiencies can be exacerbated by exercise since exercise can increase the
need for certain nutrients.
For example, lower than normal intake of magnesium along with strenuous exercise that
has been shown to increase the rate of magnesium loss via sweat and urine, can lead to a
marginal deficiency. This in turn can impair energy metabolism, muscle function, oxygen
uptake and electrolyte balance. 29, 30
Some ingredients aren’t strictly necessary but help as far as providing benefits for
improving body composition and exercise performance. For example, quercetin, which is
present in my Antiox, has been shown to increase brain and muscle mitochondrial
biogenesis and exercise tolerance, and thus may enhance athletic performance. 31
Alpha lipoic acid (in Antiox and EFA+) has been shown to enhance insulin sensitivity,
decrease post exercise lactic acid concentrations, and have potent antioxidant and antiinflammatory properties. 32
Many of the nutrients have multiple actions in the body. For example selenium also has
significant anti-inflammatory properties. 33
Exercise can lead to an increased need for certain nutrients. For example, one study found
that there is an increase in selenium requirements with exercise. 34 Problems can arise
from exercise induced mineral loss, which is further enhanced by the finding that many of
us don’t consume adequate amounts of many essential minerals. Studies have shown that
many athletes, and female athletes, in particular, consume diets that have been found to
be inadequate for certain key minerals such as zinc, magnesium, copper, and iron. The
combination of strenuous exercise and compromised mineral status ultimately leads to low
endurance capacity, depressed immune function, and the development of a variety of
disease conditions.
The bottom line is that anyone who exercises should be taking a good daily multiple
vitamin and mineral supplement, to make sure that they’re not suffering from any marginal
deficiencies, to make use of higher levels of certain nutrients that may offer physiological
benefits, and as a preventative measure for some conditions and diseases.
There can also be marked health and in some cases treatment benefits to making sure
you’re not marginally deficient in any of the vitamins, minerals, and fatty acids. 35, 36, 37, 38
For example low intakes of certain vitamins are associated with increased risk of certain
cancers. 39
The essential fatty acids are also necessary for optimal health as well as helping to
maximize body composition and performance.
Overall, there is substantial evidence that the use of the three foundation supplements,
MVM, EFA+, and Antiox can provide both short and long term benefits.
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