JAC

JAC
The Journal of Antimicrobial Chemotherapy
Volume 69 Number 10
October 2014
Contents
Review
Pharmacokinetics and pharmacodynamics of boosted once-daily darunavir
Thomas N. Kakuda, Anne Brochot, Frank L. Tomaka, Tony Vangeneugden, Tom Van De Casteele and
Richard M. W. Hoetelmans
Systematic reviews
Tigecycline in treatment of multidrug-resistant Gram-negative bacillus urinary tract infections:
a systematic review
K. Brust, A. Evans and R. Plemmons
Adverse effects associated with ethanol catheter lock solutions: a systematic review
Leonard A. Mermel and Neha Alang
Original research
Characterization of pFOX-7a, a conjugative IncL/M plasmid encoding the FOX-7 AmpC-type b-lactamase,
involved in a large outbreak in a neonatal intensive care unit
Vincenzo Di Pilato, Fabio Arena, Tommaso Giani, Viola Conte, Stefania Cresti and Gian Maria Rossolini
A conjugative plasmid carrying the carbapenem resistance gene blaOXA-23 in AbaR4 in an extensively
resistant GC1 Acinetobacter baumannii isolate
Mohammad Hamidian, Johanna J. Kenyon, Kathryn E. Holt, Derek Pickard and Ruth M. Hall
Characterization of plasmids carrying the blaOXA-24/40 carbapenemase gene and the genes encoding the
AbkA/AbkB proteins of a toxin/antitoxin system
Noraida Mosqueda, Eva Gato, Ignasi Roca, Marı´a Lo´pez, Carlos Ruı´z de Alegrı´a, Felipe Ferna´ndez Cuenca,
Luis Martı´nez-Martı´nez, Jero´nimo Pacho´n, Jose´ Miguel Cisneros, Jesu´s Rodrı´guez-Ban˜o, A´lvaro Pascual,
Jordi Vila, Germa´n Bou and Marı´a Toma´s on behalf of GEIH-GEMARA (SEIMC) and REIPI
2591
2606
2611
2620
2625
2629
Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis 2634
Yaligara Veeranagouda, Fasahath Husain, Renata Boente, Jane Moore, C. Jeffrey Smith, Edson R. Rocha,
Sheila Patrick and Hannah M. Wexler
Presence of disinfectant resistance genes in Escherichia coli isolated from retail meats in the USA
Likou Zou, Jianghong Meng, Patrick F. McDermott, Fei Wang, Qianru Yang, Guojie Cao, Maria Hoffmann and
Shaohua Zhao
2644
Characterization of extended-spectrum b-lactamase (ESBL)-producing Escherichia coli obtained from
Danish pigs, pig farmers and their families from farms with high or no consumption of third- or
fourth-generation cephalosporins
Anette M. Hammerum, Jesper Larsen, Vibe D. Andersen, Camilla H. Lester, Timmy S. Skovgaard Skytte,
Frank Hansen, Stefan S. Olsen, Hanne Mordhorst, Robert L. Skov, Frank M. Aarestrup and Yvonne Agersø
2650
Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli
isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans
Juan Wang, Roger Stephan, Karen Power, Qiongqiong Yan, Herbert Ha¨chler and Se´amus Fanning
2658
Extended-spectrum and AmpC b-lactamase-producing Escherichia coli in broilers and people living and/or
working on broiler farms: prevalence, risk factors and molecular characteristics
P. M. C. Huijbers, E. A. M. Graat, A. P. J. Haenen, M. G. van Santen, A. van Essen-Zandbergen, D. J. Mevius,
E. van Duijkeren and A. H. A. M. van Hoek
2669
Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses 2676
Christa Ewers, Ivonne Stamm, Yvonne Pfeifer, Lothar H. Wieler, Peter A. Kopp, K. Schønning,
Ellen Prenger-Berninghoff, Sandra Scheufen, Inka Stolle, Sebastian Gu¨nther and Astrid Bethe
Molecular basis of non-mutational derepression of ramA in Klebsiella pneumoniae
Shyamasree De Majumdar, Jing Yu, James Spencer, Irina G. Tikhonova and Thamarai Schneiders
2681
Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated
from cystic fibrosis (CF) and non-CF patients
2690
Laura J. Sherrard, Bettina Schaible, Kathryn A. Graham, Stef J. McGrath, Leanne McIlreavey, Joseph Hatch,
Matthew C. Wolfgang, Marianne S. Muhlebach, Deirdre F. Gilpin, Thamarai Schneiders, J. Stuart Elborn and
Michael M. Tunney
Carbapenemase and virulence factors of Enterobacteriaceae in North Lebanon between 2008 and 2012:
evolution via endemic spread of OXA-48
R. Beyrouthy, F. Robin, F. Dabboussi, H. Mallat, M. Hamze´ and R. Bonnet
Incidence rates of carbapenemase-producing Enterobacteriaceae clinical isolates in France: a prospective
nationwide study in 2011 – 12
Je´roˆme Robert, Alix Pantel, Audrey Me´rens, Jean-Philippe Lavigne and Marie-He´le`ne Nicolas-Chanoine on
behalf of ONERBA’s Carbapenem Resistance Study Group
Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and
Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011 – 12)
Helio S. Sader, David J. Farrell, Mariana Castanheira, Robert K. Flamm and Ronald N. Jones
A novel benzonitrile analogue inhibits rhinovirus replication
Ce´line Lacroix, Jordi Querol-Audı´, Manon Roche, David Franco, Mathy Froeyen, Pablo Guerra, Thierry Terme,
Patrice Vanelle, Nu´ria Verdaguer, Johan Neyts and Pieter Leyssen
2699
2706
2713
2723
Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity
of the HIV integrase enzyme and viral replication capacity
2733
Thibault Mesple`de, Nathan Osman, Melissa Wares, Peter K. Quashie, Said Hassounah, Kaitlin Anstett,
Yingshan Han, Diane N. Singhroy and Mark A. Wainberg
Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes:
role of the genetic barrier to resistance
2741
Cla´udia P. Muniz, Marcelo A. Soares and Andre´ F. Santos
Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family
Geoffrey Fe´rir, Dana Huskens, Sam Noppen, Leonardus M. I. Koharudin, Angela M. Gronenborn and
Dominique Schols
2746
The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug
resistance
2759
Huihui Chong, Xue Yao, Zonglin Qiu, Jianping Sun, Yuanyuan Qiao, Meng Zhang, Meitian Wang, Sheng Cui and
Yuxian He
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705),
a broad-spectrum antiviral
Leen Delang, Nidya Segura Guerrero, Ali Tas, Gilles Que´rat, Boris Pastorino, Mathy Froeyen, Kai Dallmeier,
Dirk Jochmans, Piet Herdewijn, Felio Bello, Eric J. Snijder, Xavier de Lamballerie, Byron Martina, Johan Neyts,
Martijn J. van Hemert and Pieter Leyssen
In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal
persistence during antifungal therapy
Ilse D. Jacobsen, Anja Lu¨ttich, Oliver Kurzai, Bernhard Hube and Matthias Brock
Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard
dosing approaches are required to achieve therapeutic exposures
Mieke Carlier, Michae¨l Noe¨, Jason A. Roberts, Veronique Stove, Alain G. Verstraete, Jeffrey Lipman and
Jan J. De Waele
2770
2785
2797
Switching from tenofovir/emtricitabine and nevirapine to a tenofovir/emtricitabine/rilpivirine single-tablet
regimen in virologically suppressed, HIV-1-infected subjects
C. Allavena, E. Dailly, V. Reliquet, B. Bonnet, S. Pineau, E. Andre´-Garnier, D. Boutoille, R. Bouquie´, A. Raveleau,
S. Bouchez, E. Billaud and F. Raffi
Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in
treatment-naive patients
Christoph Stephan, Hanna-Mari Baldauf, Joanne Barry, Frank A. Giordano, Cynthia C. Bartholomae,
Annette Haberl, Markus Bickel, Manfred Schmidt, Stephanie Laufs, Lars Kaderali and Oliver T. Keppler
2804
2809
Virological outcome at week 48 of three recommended first-line regimens using ultrasensitive viral load and
plasma drug assay
2819
Charlotte Charpentier, Marion Choquet, Ve´ronique Joly, Patrick Yeni, Benoit Visseaux, Marion Caseris,
Franc¸oise Brun-Ve´zinet, Yazdan Yazdanpanah, Gilles Peytavin, Diane Descamps and Roland Landman
Factors associated with mortality among persistently viraemic triple-antiretroviral-class-experienced patients
receiving antiretroviral therapy in the HIV Outpatient Study (HOPS)
2826
Frank J. Palella Jr, Carl Armon, Kate Buchacz, Joan S. Chmiel, Richard M. Novak, Richard T. D’Aquila and
John T. Brooks on behalf of the HOPS Investigators
Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections
caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3
clinical trial data
2835
George G. Zhanel, Kevin D. Wolter, Cristina Calciu, Patricia Hogan, Donald E. Low, Karl Weiss and
James A. Karlowsky
Clinical significance of 2 h plasma concentrations of first-line anti-tuberculosis drugs: a prospective
observational study
Julie B. Prahl, Isik S. Johansen, Arieh S. Cohen, Niels Frimodt-Møller and A˚se B. Andersen
2841
The efficacy of non-carbapenem antibiotics for the treatment of community-onset acute pyelonephritis due
to extended-spectrum b-lactamase-producing Escherichia coli
2848
Sun Hee Park, Su-Mi Choi, Yoon Kyung Chang, Dong-Gun Lee, Sung-Yeon Cho, Hyo-Jin Lee, Jung-Hyun Choi
and Jin-Hong Yoo
Impact of a computerized decision support system on compliance with guidelines on antibiotics prescribed
for urinary tract infections in emergency departments: a multicentre prospective before-and-after controlled
interventional study
2857
Elisa Demonchy, Jean-Charles Dufour, Jean Gaudart, Emmanuel Cervetti, Pierre Michelet, Nicolas Poussard,
Jacques Levraut and Ce´line Pulcini
Research letters
Detection of mecC methicillin-resistant Staphylococcus aureus with a semi-selective enrichment broth
C. Ekenberg, K. Boye, K. Schønning, H. Westh and G. Lisby
2864
Resistance to third-generation cephalosporins in Acinetobacter baumannii due to horizontal transfer of a
chromosomal segment containing ISAba1-ampC
Mohammad Hamidian and Ruth M. Hall
2865
Identification of fluoroquinolone-resistant extended-spectrum b-lactamase (CTX-M-8)-producing Escherichia
coli ST224, ST2179 and ST2308 in buffalo (Bubalus bubalis)
2866
Juliana Aizawa, Natalie Neuwirt, Leandro Barbato, Patrı´cia R. Neves, Lucianne Leigue, Joa˜o Padilha,
Antonio F. Pestana de Castro, Lilian Gregory and Nilton Lincopan
Isolation of ciprofloxacin-resistant Legionella pneumophila in a patient with severe pneumonia
Jacob P. Bruin, Tetyana Koshkolda, Ed P. F. IJzerman, Christian Lu¨ck, Bram M. W. Diederen,
Jeroen W. Den Boer and Johan W. Mouton
2869
Molecular surveillance and prevalence of carbapenem-resistant Enterobacteriaceae in Northern Taiwan
Wen-Shyang Hsieh, Nai-Yu Wang, Jou-An Feng, Li-Chuan Weng and Hsueh-Hsia Wu
2871
In vitro activity of mecillinam against Enterobacteriaceae with NDM-1 carbapenemase
Emma C. L. Marrs, Kathryn M. Day and John D. Perry
2873
Favourable outcome in the treatment of carbapenem-resistant Enterobacteriaceae urinary tract infection
with high-dose tigecycline
K. Brust, A. Evans and R. Plemmons
Measurement units for antibiotic consumption in outpatients
Milan Cˇizˇman
2875
2877
An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment
of cancer therapy
2878
Johan Vande Voorde, Jan Balzarini and Sandra Liekens
Letter to the Editor
Comment on: Antiretroviral treatment French guidelines 2013: economics influencing science
P. Morlat and B. Hoen on behalf of the 2013 French HIV Expert Group
2881