Toxicology and Drug Development About ADMET Tutorial Series

IVAL-BHTC ADMET Tutorial Series
IVAL Boston Hepatocyte Technology Center
389 Main Street, Malden, MA
Toxicology and Drug Development
About ADMET Tutorial Series
The focus of IVAL-BHTC ADMET tutorial
series is to provide expert tutorials on stateof-the art drug discovery and development
science and technology, with emphasis on
drug metabolism, drug-drug interactions,
and toxicology.
Toxicology and Drug Development is the
inaugural ADMET tutorial to be presented by
Professor A. Wallace Hayes, co-editor of
“Hayes' Principles and Methods of
Toxicology, 6th edition.” Professor Hayes is
a prestigious internationally-renowned
toxicologist with extensive industrial
experience.
This two-day course will provide attendees
with an overview of the key concepts of
November 4th & 5th 2014
toxicology in drug development,
experimental protocols for preclinical and
clinical safety studies, data interpretation,
and safety assessment.
Dr. Albert P. Li, an internationally renowned
expert on in vitro drug evaluation, will join
Dr. Hayes to lecture on in vitro approaches
to evaluate adverse drug properties.
Toxicology and Drug Development is
intended for scientists and professionals
from pharmaceutical companies, academic
institutions, regulatory agencies, and
contract research organizations who are
interested in an updated overview of the
science and practice of toxicology in drug
development.
Lecture Syllabus and Timetable
Lecture Titles
Tuesday
Nov 4th
10 am
to
5 pm
Wednesday
Nov 5th
9 am
to
4:30 pm
Principles and scientific concepts of toxicology
Absorption, metabolism, disposition, and excretion of administered drugs
Lecturer
Hayes
Hayes

Lunch Break
Mechanism of action of toxic drugs
Experimental protocols for toxicological evaluation in drug development
Hayes
Hayes
Dose-response relationship and risk assessment
Translational biology and toxicology
Hayes
Hayes

Lunch Break
In vitro approaches to evaluate adverse drug effects: Drug-drug interactions
In vitro approaches to evaluate adverse drug effects: Drug toxicity
Class discussion
In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045
[email protected] (410) 869-9037
www.invitroadmet.com
Li
Li
Hayes and Li
Toxicology and Drug Development
Dates: November 4th & 5th 2014
Page |2
Faculty
A. Wallace Hayes,
Ph.D., D.A.B.T., FATS,
FIBiol, FACFE, FACN,
ERT, CNS
Dr. Hayes is a toxicologist
with over 35 years of
experience in industry
and academics. He is a
Senior Science Advisor at Spherix Consulting,
providing strategic, scientific and regulatory
guidance. Dr. Hayes lectures at Harvard
University and also holds an appointment with
the School of Public Health, University of
Massachusetts, Amherst as a Research Professor.
Dr. Hayes is the Editor-in-Chief, Food and
Chemical Toxicology, and has authored more
than 200 peer reviewed publications, is the coeditor of Hayes' Principles and Methods of
Toxicology, 6th Edition, Human and Experimental
Toxicology, Cutaneous and Ocular Toxicology,
and co-editor of the Target Organ Toxicity Series.
Albert P. Li, Ph.D.
Dr. Li is the President,
CEO and co-founder of
In
Vitro
ADMET
Laboratories LLC. His
research is focused on
the development and
application of humanbased
in
vitro
experimental models, especially primary
cultured human hepatocytes, in the accurate
assessment of human drug properties including
metabolic fate, drug-drug interactions and drug
toxicity. Dr. Li was one of the first scientists to
successfully cryopreserve human hepatocytes to
retain properties of freshly isolated cells, and the
inventor of the patented Integrated Discrete
Multiple Organ Co-culture (IdMOC) system,
which allows cells from multiple organs to be
interconnected to emulate an entire organism.
Dr. Li has published approximately 160 research
papers/book chapters/reviews and edited/coedited 6 books in toxicology, drug metabolism,
and cell biology.
In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045
[email protected] (410) 869-9037
www.invitroadmet.com
Toxicology and Drug Development
Dates: November 4th & 5th 2014
Page |3
General Information
The IVAL Boston Hepatocyte Training Center
(IVAL-BHTC) is conveniently located in
downtown Malden, Massachusetts, USA. The
facility is within walking distance from the
Massachusetts Bay Transportation Authority.
www.mbta.com. Please reference the map
insert.
Directions for mass transit: take the Orange line
to Malden Center. When exiting the Malden
Center station, cross Commercial Street at the
light. This will put you directly in front of the
Malden Government Center. As you face the
building, turn left and walk to Pleasant Street
and take a right. Follow Pleasant Street to Main
Street. We are across the Main Street at the
“City Center” Building – 389 Main Street, 3rd
Floor, Malden, MA.
Parking: Jackson Street Garage, located on
Jackson Street between Centre Street and
Exchange Street or CBD Garage located on
Middlesex Street, between Centre Street and
Exchange Street, Malden MA 02148.
Parking Rates:
Per Hour: $2.00
Daily Rate: $18.00
Early Bird: $6.00 (entry before 9:00 AM, exit
before7:00 PM)
Payment: Payment may be made by check or
credit card. Checks should be made in US
dollars, payable to “In Vitro ADMET Laboratories,
LLC. “
Submit your completed registration form and
preferred method of payment to Nola Mahaney:
[email protected] or
Mail: IVAL, LLC;
9221 Rumsey Road, Suite # 8,
Columbia, MD 21045, USA
FAX: (410) 869-9034.
Cancellation Policy: All cancellations are
subjected to a $100.00 cancellation fee. Greater
than 30 days, 100% refund (less cancellation
fee). Less than 30 days, no refund, but
registration may be transferred to another
person. All refund requests must be in writing.
All refunds will be issued after the meeting has
occurred. No refunds requests will be accepted
after November 3rd, 2014. Please submit
cancellation and refund requests including
registration transfer details to: Fax: 410-8699034; E-mail: [email protected]
Academic/Government participants will receive a
50% discount.
A larger version of this map is available on request
Hotel Accommodations:
We recommend Hyatt Place Boston/Medford:
116 Riverside Avenue
Medford, Massachusetts, USA, 02155
Tel: +1 781 395 8500
http://bostonmedford.place.hyatt.com
They have shuttle service to the T stops on an asneeded basis from 7:30 am-9:00 pm each day.
In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045
[email protected] (410) 869-9037
www.invitroadmet.com
Toxicology and Drug Development
Dates: November 4th & 5th 2014
Page |4
Registration Information
To register, please fill out the following form and submit with
your selected form of payment by November 3rd, 2014.
Please note: seating is limited and will be assigned on a firstcome, first-served basis. For multiple registrations, please
provide the following information for each person.
Academic/Government participants will receive a 50%
discount.
EARLYBIRD DISCOUNT: Save over 10% if you
register by October 17th.
Preferred form of payment:
PO Number: _______________________________
Credit Card (AmEx, Visa, MC): __________________
Number: ________________________________
Security Code: ___________________________
Name on the Card: ________________________
Please check:
 November Hepatocyte Workshop: (Monday
Expiration Date: __________________________
(full day) and Tuesday (am), Nov 3rd and 4th)
$485 per person; $435 by Oct 17th
Total Amount: $_____________________________
 Toxicology and Drug Development short
Signature: _________________________________
course registration: (Tuesday and
Wednesday, Nov 4th and 5th) $485 per
person; $435 by Oct 17th
Billing Address: _____________________________
 Both workshop and course: $800 per person
(Save $170); $700 by Oct 17th
__________________________________________
__________________________________________
Billing Contact Name / Phone Number:
(Please print legibly)
__________________________________________
Name: ____________________________________
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Submit this completed form to:
Company: _________________________________
Email: Nola Mahaney, [email protected]
Fax: (410)-869-9034
Address 1: _________________________________
Address 2: _________________________________
City / ST / Zip: _______________________________
Mail: IVAL, LLC;
9221 Rumsey Road, Suite # 8,
Columbia, MD 21045, USA
E-mail: ___________________________________
Phone: ___________________________________
In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045
[email protected] (410) 869-9037
www.invitroadmet.com