EUROPEAN UNIVERSITARY DIPLOMA 2014 / 2015 Program HEPATIC-PANCREATIC AND BILIARY CANCERS:

EUROPEAN UNIVERSITARY DIPLOMA
HEPATIC-PANCREATIC AND BILIARY CANCERS:
ONCOSURGICAL STRATEGIES
2014 / 2015 Program
Session 1 / Generalities on HPB cancers. Primary hepatic malignancies and Biliary
Cancers
December 15 – 18, 2014
Monday, December 15
Hepatocellular Carcinoma (HCC)
Discussion Panel : C. Guettier, F. Kunslinger, D. Samuel, R.Adam
08h30 – 9h00
Welcome address
09h00 – 10h00
Epidemiology, carcinogenesis, natural history of HCC
10h00 – 11h00
Imaging of HCC
11h00 – 12h00
Pathology of HCC
12h00 – 13h00
Diagnosis of HCC: Practical attitude. When is it definitive?
What to do in doubtful cases ? Indications of the biopsy,
R. Adam
D. Samuel
F. Kunstlinger
C. Guettier
R. Adam
Discussion Panel : Th. De Baere, M. Ducreux, R. Adam, X. Mirabel
14h00 – 15h00
Chemotherapy of HCC: new drugs / new indications
15h00 – 16h00
Transarterial Chemoembolization
16h00 – 17h00
Conformational Radiotherapy of HCC
17h00 – 18h00
Radiofrequency, Cryotherapy, Alcohol injection
18h00 – 19h00
Imaging follow up of HCC treated by tumor ablation
or chemoembolization
M. Ducreux
S. Awad
X. Mirabel
Th. De Baere
F. Kunstlinger
Tuesday, December 16
HCC / Non-biliary Primary Hepatic Malignancies
Discussion Panel : E. Vibert, D. Cherqui
09h00 – 10h00
Translational Research. Applications in HPB cancers
10h00 – 11h00
Portal Embolization and Post operative Liver failure
Normal vs cirrhotic liver
11h00 – 12h00
Liver Resection. What patients to resect ?.
Principles. Results
12h00 – 13h00
Role of laparoscopic surgery
13h00 – 13h30
New tools in liver surgery
Discussion Panel : F. Kunstlinger, J. Lerut,
14h30 – 15h30
Transplantation for HCC : Indications and results
Resection or Transplantation as first treatment option?
15h30 - 16h00
Liver transplantation for HCC. How far can we go?
16H00 - 16H30
Angiosarcoma, Hemangioendothelioma, rare hepatic tumors
16h30 – 17h30
Primary hepatic malignancies in children
23/10/14
J. Faivre
E. Vibert
D. Cherqui
E. Vibert
R. Adam
R. Adam
J. Lerut
J. Lerut
S. Branchereau
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Wednesday, December 17
Biliary tract cancers
Discussion Panel : E. Vibert, C. Guettier, J. Figueras
09h00 – 10h00
Surgical Anatomy of the biliary tract
10h00 – 11h00
Imaging of biliary tract Cancers (intra and extrahepatic)
11h00 – 12h00
Pathology of Cholangiocarcinoma : Intrahepatic/ Klatskin
12h00 – 13h00
Staging of resectability of Klatskin tumors
E. Vibert
M. Lewin
C. Guettier
J. Figueras
Discussion Panel : H. Bismuth, G. Pelletier
14h00 – 15h00
Preoperative biliary drainage : Yes or No ?
J. Figueras
Portal embolization : When ?
15h00 – 16h00
Klastskin tumors: Palliative and curative surgery
H. Bismuth
16h00 – 17h00
Role of liver transplantation in biliary tract Cancers
R. Adam
What selection of patients?
17h00 – 17h30
What about “Pseudo Klatskin tumors”: The role of spyglass technology
Endoscopic treatment of klastskin tumor
G. Pelletier
Thursday, December 18
Biliary tract cancers (2)
Discussion Panel : C. Louvet, C. Hennequin, M. Adham
09h00 – 9h30
Chemotherapy of biliary cancers and IH cholangiocarcinoma
9h30 - 10h30
Congenital abnormalities of the extrahepatic biliary tract
Risk of malignancy – Indications of surgery
10h30 – 12h00
Radiotherapy of biliary tract Cancers
J.F. Morere
M. Adham
C. Hennequin
Discussion Panel: O. Farges A. Sauvanet, E. Vibert
13h00 – 14h00
Intrahepatic Cholangiocarcinomas
O. Farges
14h00 – 15h00
Adenocarcinoma of the gallbladder
O. Farges
15h00 – 16h00
Adenocarcinoma of the Ampulla of Vater
A. Sauvanet
Indications and role of local surgery
16h00 – 17h00
Presentation of clinical cases of HCC or cholangiocarcinomas (case +video)
23/10/14
2
Session 2 / Liver Metastases from Colorectal Cancer
February 9 – 13, 2014
Monday, February 9
Discussion Panel: T. André, C. Guettier, A. Lemoine, M. Lewin
09h00 – 10h00
What Follow-up after colorectal cancer and what type
of adjuvant chemotherapy?
10h00 – 11h00
Imaging by ultrasound, CT Scan and MRI
11h00 – 13h00
Hepatic Metastases: new prognostic markers
Inpact of Molecular Biology on treatment and prognosis
Pathology : New prognostic markers
Discussion Panel: E. Zerbib, E. Vibert, F. Kunstlinger,
14h00 – 15h00
Intraoperative liver ultrasound
15h00 – 16h00
In practice: What check up for an optimal imaging ?
17h00 – 18h00
Pet-Scan. Improvements in Diagnosis and in
therapeutic strategy
Th. André
M. Lewin
A. Lemoine
C. Guettier
E.Vibert
F. Kunstlinger
E. Zerbib
Tuesday, February 10
Discussion Panel : A. De Gramont, J. Figueras, R. Adam
09h00 – 10h00
Systemic Chemotherapy in metastases CRC:
A. De Gramont
What is the optimal treatment ? Resectability : a new end point ?
10h00 – 11h00
Liver resection. Principles, prognostic factors, practical policy J. Figueras
11H00 – 12H30
Resection of non resectable metastases after chemotherapy
R. Adam
- Impact of targeted therapies
- Complete response after chemotherapy : a goal to achieve ?
- What to do in case of complete radiological response ?
Discussion Panel : F. Lévi, M. Ducreux, R. Adam
13h30 – 14h30
Chrono-modulated chemotherapy : Principles, Indications
14h30 – 15h30
Intra-arterial Chemotherapy : The reappraisal ?
F. Lévi
M. Ducreux,
F. Lévi
Wednesday, February 11
Discussion Panel : R. Adam, E. Housseau, G. Poston
09h00 – 10h00
Resectability of liver metastases : Better definition
G. Poston
Towards an international standard ?
What impact on classification?
10h00 – 12h00
Synchronous liver metastases
Chemotherapy first or surgery of the primary ? (30 min)
R. Adam
One-stage Resection ? (30 min)
or
E. Housseau
Two-stage Resection ? (30 min)
Discussion (30 min)
12H00 – 13H00
Metachronous Liver Metastases:
R. Adam
Rationale for neoadjuvant chemotherapy of resectable metastases
When Is it useful ?
23/10/14
3
Discussion Panel : F. Kunslinger, M. Sebagh, R. Adam
14h00 – 15h00
Effects of chemotherapy on the liver. Clinical Implications
15h00 – 16h00
16h00 – 17h00
17h00 – 18h00
M. Sebagh,
R. Adam
F. Kunstlinger
E. Paillaud
Radiological assessment of chemotoxicity on the liver
Elderly patients : What oncosurge strategy ?
«LiverMetSurvey»: an international registry of patients operated
for colorectal metastases: rationale and results
R. Adam,
D. Delvart
Thursday, February 12
How to Increase the resectablity of Liver Metastases ?
Discussion Panel : E. Vibert, F. Kunstlinger, F. Lévi, R. Adam
09h00 – 10h00
Portal Embolization
10h00 – 11h00
How to increase resectability with hepatic arterial infusion?
11h00 – 12h00
Two-stage hepatectomy and ALPPS
12h00 –13h00
Extreme Liver surgery: total vascular exclusion, extracorporeal
bypass, hepatic cooling
Discussion Panel : E. Vibert, R. Adam, G. Tozilli
14h00 – 15h00
The use of IOUS by the hepatic surgeon. Application to
IOUS-guided one stage hepatectomy for multiple metastases
15h00 – 16h00
Laparoscopic surgery: Present indications and results
16h00 – 17h00
Discussion : which procedure for which patients ?
17h00 – 18h00
Liver transplantation: is there any rationale to be revisited
E. Vibert
D. Goere
R. Adam
M. Gelli / R. Adam
G.Torzilli
D. Cherqui
R. Adam
R. Adam
Friday, February 13 Recurrence of metastases
Discussion Panel : R Adam, F. Kunstlinger, F.Lévi
09h00 – 10h00
Risks and prognostic factors of recurrence
10h00 – 11h00
How to prevent it ?
F. Lévi
Adjuvant chemotherapy after hepatectomy : how and when?
11h00 – 12h00
How to detect it ? Imaging: What optimal follow-up ?
F. Kunstlinger
12h00 – 13h00
How to treat it ? Repeat hepatectomy: Indications and results. O. Ciacio
Discussion Panel : F. Kunstlinger, F.Lévi , R. Adam
14h00 – 15h00
Radiofrequency : an alternative to repeat resection?
15h00 – 16h00
Surgery of pulmonary metastases
16h00 – 17h00
Surgery of extrahepatic metastases (other sites)
17h00 – 18h00
Discussion forum: case Reports
23/10/14
F. Deschamps
R. Adam
D. Goéré
R. Adam, E. Vibert
4
Session 3 / Non-Colorectal Liver Metastases – Cancer of the Pancreas
May 18 - 22, 2015
Monday, May 18
Non colorectal, Non Endocrine Metastases : Metastases of known origin
Discussion Panel : M. Ducreux, F. Kunstlinger
09h00 –10h00
Liver Metastases from Upper GI cancer
10h00 – 11h00
11h00 –12h00
From Melanoma
From Urinary tract cancers
Discussion Panel : S. Giacchetti, D.Goéré
13h00 – 14h00
From Breast cancer
M. Ducreux,
R. Adam
P. Mariani,
R. Adam
S. Giacchetti,
R. Adam
D. Goéré
A. Le Cesne,
R. Adam
14h00 – 15h00
15h00 – 16h00
16h00 – 17h00
From Uterus, Ovarian or Testis carcinoma
GIST and other sarcomas
Summary: When to propose surgery of non colorectal
non endocrine metastases ?
Tuesday, May 19
Non colorectal, Non Endocrine Metastases : Metastases of unknown origin
Discussion Panel : M. Lewin, C. Guettier, J.P. lotz, E. Vibert, R Adam
9h00 – 10h00
What diagnostic and therapeutic strategy to propose ?
10h00 – 11h00
Tumor Imaging : Specificity in relation to the primary
11h00 – 12h00
How can the liver biopsy help the diagnosis of the primary ?
12h00 – 13h00
Pathology of endocrine tumors
J.P. Lotz
M. Lewin
C. Guettier
C. Guettier
Carcinoid and Endocrine Metastases
Discussion Panel : M. Lewin, M. Ducreux, C. Guettier, R. Adam
14h00
15h00
16h00
17h00
–
–
–
–
15h00
16h00
17h00
18h00
Wednesday, May 20
Imaging of hepatic metastases from endocrine tumors
Clinical presentation and biological aspects
Place of chemotherapy and chemoembolization
Liver resection and Transplantation
Respective indications and results
Cancer of the Pancreas
Discussion Panel : J.R. Delpero, A. Sa Cunha, J.Y. Scoazec, M. Zins,
9h00 – 10h00
Surgical anatomy of the pancreas
10h00 – 11h00
Pathology of malignant tumors of the pancreas
11h00 – 12h00
Imaging of malignant tumors of the pancreas
12h00 – 13h00
Diagnostic and interventional echoendoscopy
Discussion Panel : J.R. Delpero, A. Sa Cunha, A. Sauvanet
14h00 – 15h00
Preoperative check up. Staging of resectability
Preoperative biliary drainage: yes or no ?
15h00 – 16h00
Margings of resection => Critical Study
16h00 – 17H00
Place of radiofrequency for pancreatic adenocarcinoma
23/10/14
M. Lewin
M. Ducreux
M. Ducreux,
A. Sa Cunha
J.R Delpero
J.Y. Scoazec
M. Zins
E. Bories
A. Sauvanet
J.R. Delpero
E. Deutsch
5
Thursday, May 21
Cancer of the Pancreas (2)
Discussion Panel : J.R. Delpero, A. Sa Cunha, C. Louvet,
9h00 – 10h00
Vascular resection with pancreatectomy
10h00 – 11h00
Adjuvant treatment after resection
Today and perspectives
11h00 – 12h00
Translational research. Results and perspectives
Discussion Panel : J.R. Delpero, C. Louvet, M. Adham, A. Sa Cunha
13h00 –14h00
Borderline and locally advanced
How to manage?
14h00 – 15h00
Surgery after neoadjuvant treatment
15h00 – 16h00
Lessons from the French 5 years experience
Friday, May 22
Discussion Panel : J.R. Delpero, C.Louvet, , M. Adham, A. Sa Cunha
14h00 – 15h00
Methods of resection for invasive and non invasive IPNMs
15h00 – 16h00
Follow-up of resected and non resected IPNMS
23/10/14
J.B. Bachet
P. Hammel
A. Sa Cunha
J.R. Delpero
Tumors of the Pancreas
Discussion Panel : J.R. Delpero, A. Sa Cunha, M. Adham, F. Paye
9h00 – 10h00
Endocrine Tumors: Classification and staging system
10h00 – 11h00
Endocrine Tumors: Diagnostic and treatment
11h00 – 12h00
Diagnosis algorithm and decision making for
a cystic pancreatic tumour
12h00 – 13h00
Intrapancreatic papillary and mucinous tumors.
Arguments for malignancy, Indications for resection
16h30-17h30
P. Bachellier
C. Louvet
A. Couvelard
P. Pessaux
M. Adham
F. Paye
A. Sa Cunha
V. Rebours
Final Examination
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