Elutra CELL SEPARATION SYSTEM A Functionally Closed System for Monocyte Enrichment

MONOCYTE ENRICHMENT
Elutra®
cell SEPARATION SYSTEM
A Functionally Closed System for Monocyte Enrichment
without Pre-Processing or Expensive Antibodies
The Elutra system uses counter-flow centrifugal
elutriation―fluid flowing through cell layers in a
centrifugal field―to enrich monocytes based on
size and density.
Predictable monocyte enrichment direct from
leukapheresis products in less than one hour…
from set up to completion
Elutra system’s reproducible process is designed to provide
60 percent monocyte recovery*
n 80 percent monocyte purity*
n Enrichment with the Elutra System is fast and easy
Connect your starting cell product to the Elutra system’s disposable
tubing set
n Set up and prime the tubing set
n Load the separation chamber with cells
n Select and perform the desired separation profile (automated red
blood cell debulking optional)
n Disconnect the enriched monocyte product bag from the tubing set
n Monocyte enrichment in the Elutra Separation Chamber
Unlocking the Potential of Blood
* Typical results based on cell counts from a leukapheresis product collected the previous day from normal donors
on a COBE® Spectra™ Apheresis System. 80 to 230 ml products contained 5 to 14 x 109 WBC count, 80 to 100%
mononuclear cell, and 1.8 to 4.7 ml red blood cell volume.
MONOCYTE ENRICHMENT
Elutra cell SEPARATION SYSTEM
High Purity, High Yield Monocytes
Initial TNC
N=7
5.9 -10.3 x 10
% of Monocyte Recovery
% of Monocyte Purity
67 ± 15
75 ± 13
9
Read E.J., et al, NIH Department of Transfusion Medicine, Bethesda, MD; Gambro BCT, Lakewood, CO. 2003. Evaluation of a Closed Automated System to Isolate
Peripheral Blood Monocytes for Dendritic Cell (DC) Immunotherapy. Ninth annual meeting of the ISCT, 29 May–1 June.
Elutra Combines Convenience and Performance
Automated Optional Red Blood Cell Debulking
of Leukapheresis Products Containing more than
4 mL of Red Cells
D
esigned to Provide High Purity and Recovery
of Monocytes without Gradient Solutions
A
llows consistent processing of Cellular
Starting Material in a Single Run*
Semi-automated system with nine
User-Defined Separation Profiles
Helps Standardize the Enrichment Process
User-Friendly Interface that Guides the Operator
Through System Set Up and Prompts when to
Initiate the Next Fraction Collection
Reduces the Risk of Operator Error
Unique Conical Separation Chamber Designed to
Process from 5 x 109 to 20 x 109 Nucleated Cells*
Red blood cell debulking in the elutra separation chamber
* Typical results based on cell counts from a leukapheresis product collected the previous day from normal donors on a COBE Spectra system. 80 mL to 230 mL products contained 5 to14 x 109 white blood cell count, 80
to100% mononuclear cell, and 1.8 mL to 4.7 mL red blood cell volume.
Note to U.S. and Canadian Customers: Terumo BCT considers the Elutra system for laboratory use and not subject to pre-market clearance by the U.S. Food & Drug Administration or licensure by Health Canada.
Cells processed on this system, which are intended for direct transfusion or are used in the production of a therapeutic product(s) or vaccine(s) for clinical use, may require advance regulatory clearance or approval, which
is the sole responsibility of the user.
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