Table of Contents

Circulation
Volume 131 ◼ Number 6
February 10, 2015
Clinical Summaries. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 517
Editorials
Making Sense of Genome-Wide Association Studies: Integrating Genetic Variation With Gene Expression to
Derive Functional Mechanisms Underlying Disease Risk
Hsiao-Huei Chen, PhD; Alexandre F. R. Stewart, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 519
What the Dead Can Teach the Living: Systemic Nature of Heart Failure With Preserved Ejection Fraction
Dalane W. Kitzman, MD; Bharathi Upadhya, MD; Sujethra Vasu, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 522
How to Repeat a Success and Control a Bad Influence
Göran K. Hansson, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 525
Original Articles
Coronary Heart Disease
Interaction of Impaired Coronary Flow Reserve and Cardiomyocyte Injury on Adverse Cardiovascular
Outcomes in Patients Without Overt Coronary Artery Disease
Viviany R. Taqueti, MD, MPH; Brendan M. Everett, MD, MPH; Venkatesh L. Murthy, MD, PhD; Mariya Gaber, MS;
Courtney R. Foster, MS; Jon Hainer, BS; Ron Blankstein, MD; Sharmila Dorbala, MD, MPH; Marcelo F. Di Carli, MD CME . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 528
Genetics
Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease
Phenotypes
Chen Yao, PhD; Brian H. Chen, PhD, MPH; Roby Joehanes, PhD; Burcak Otlu, MSc; Xiaoling Zhang, PhD;
Chunyu Liu, PhD; Tianxiao Huan, PhD; Oznur Tastan, PhD; L. Adrienne Cupples, PhD; James B. Meigs, MD, MPH;
Caroline S. Fox, MD, MPH; Jane E. Freedman, MD; Paul Courchesne, MBA; Christopher J. O’Donnell, MD, MPH;
Peter J. Munson, PhD; Sunduz Keles, PhD; Daniel Levy, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 536
Heart Failure
Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure With Preserved Ejection
Fraction
Selma F. Mohammed, MBBS; Saad Hussain, MBBS; Sultan A. Mirzoyev, MD; William D. Edwards, MD;
Joseph J. Maleszewski, MD; Margaret M. Redfield, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 550
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Vascular Medicine
Control of the T Follicular Helper–Germinal Center B-Cell Axis by CD8+ Regulatory T Cells Limits
Atherosclerosis and Tertiary Lymphoid Organ Development
Marc Clement, PhD; Kevin Guedj, PhD; Francesco Andreata, MSc; Marion Morvan, MSc; Laetitia Bey, MSc;
Jamila Khallou-Laschet, PhD; Anh-Thu Gaston, MSc; Sandrine Delbosc, PhD; Jean-Marc Alsac, MD, PhD;
Patrick Bruneval, MD, PhD; Catherine Deschildre, MSc; Marie Le Borgne, PhD; Yves Castier, MD, PhD;
Hye-Jung Kim, PhD; Harvey Cantor, MD, PhD; Jean-Baptiste Michel, MD, PhD; Giuseppina Caligiuri, MD, PhD;
Antonino Nicoletti, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 560
Valvular Heart Disease
Endocarditis Pathogen Promotes Vegetation Formation by Inducing Intravascular Neutrophil Extracellular
Traps Through Activated Platelets
Chiau-Jing Jung, PhD; Chiou-Yueh Yeh, PhD; Ron-Bin Hsu, MD; Chii-Ming Lee, MD; Chia-Tung Shun, MD;
Jean-San Chia, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 571
Recent Advances in Pulmonary Hypertension
Pathophysiology and Treatment of High-Altitude Pulmonary Vascular Disease
Martin R. Wilkins, MD; Hossein-Ardeschir Ghofrani, MD; Norbert Weissmann, PhD; Almaz Aldashev, PhD;
Lan Zhao, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 582
ECG Challenge Response
ECG Response: February 10, 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 591
Images in Cardiovascular Medicine
Recurrent Right Coronary Artery Occlusion Caused by Cardiac Fibroelastoma Attached to the Aortic Valve
Kavitha Vimalesvaran, MSc, MRCP; Matthew Lumley, BSc, MRCP; Nicholas Child, BSc, MRCP;
Simon Redwood, MD, FRCP; Christopher Blauth, MBBS, FRCS; Eike Nagal, MD, PhD; Divaka Perera, MD, FRCP . . . . . 593
Fungal Endocarditis After Hybrid Periventricular Closure of Muscular Ventricular Septal Defect by
Amplatzer Occluder in a Child
Sabrina Bressieux-Degueldre, MD; Nicole Sekarski, MD; Stefano Di Bernardo, MD . . . . . . . . . . . . . . . . . . . . . . . . . . e339
Correspondence
Letter by Herzig Regarding Article, “Electronic Cigarettes: A Scientific Review”
Zvi Herzig, MPH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e341
Response to Letter Regarding Article, “Electronic Cigarettes: A Scientific Review”
Rachel Grana, PhD, MPH; Neal Benowitz, MD; Stanton Glantz, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e342
Letter by Psaty et al Regarding Article, “Heart Failure With Recovered Ejection Fraction: Clinical
Description, Biomarkers, and Outcomes”
Bruce M. Psaty, MD, PhD; Sanjiv J. Shah, MD; John Gottdiener, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e343
Response to Letter Regarding Article, “Heart Failure With Recovered Ejection Fraction: Clinical Description,
Biomarkers, and Outcomes”
Anupam Basuray, MD, MPH; Benjamin French, PhD; Bonnie Ky, MD, MSCE; Esther Vorovich, MD; Caroline Olt, BA;
Nancy Sweitzer, MD, PhD; Thomas Cappola, MD, ScM; James C. Fang, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e344