22q11 deletion syndrome growth charts

GROWTH CHARTS FOR 22q11 DELETION SYNDROME
A collaborative study between Great Ormond Street Hospital for Children London (GOSH), and
Children’s Hospital of Philadelphia (CHOP) to produce five centile (9th, 25th, 50th, 75th, 91st) lines for
weight, height, body mass index (BMI) and head circumference of Caucasian subjects
Weight and height are plotted against WHO Reference centiles birth to 5 years alone and combined
with US CDC 2000 Reference centiles 5 to 20 years, BMI from 2 to 20 years. Head circumference is
plotted against WHO Reference centiles from birth to 5 years alone and combined with UK
Reference centiles 5 to 20 years.
22q11 Deletion Syndrome (22q11DS) solid lines, US and UK Reference (R) dotted lines.
kgs
Boys Weight 22q11DS and WHO Centiles
Birth to 5 years
25
WHO p91
22q p91
WHO p75
22q p75
WHO p50
22q p50
WHO p25
22q p25
WHO p9
22q p9
20
15
10
5
0
0
1
2
3
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
4
5
kgs
100
Boys Weight 22q11 DS and Reference (R) Birth to 20 years
R p91
22q p91
90
R p75
22q p75
80
R p50
70
22q p50
R p25
60
22q p25
R p9
50
22q p9
40
30
20
10
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
Girls Weight 22q11 DS and WHO Centiles
Birth to 5 years
kgs
25
WHO p91
22q p91
WHO p75
20
22q p75
WHO p50
22q p50
WHO p25
22q p25
15
WHO p9
22q p9
10
5
0
0
1
2
3
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
4
5
Girls Weight 22q11 DS and Reference (R) Birth to 20 years
kgs
80
R p91
22q p91
70
R p75
22q p75
R p50
60
22q p50
R p25
22q p25
50
R p9
22q p9
40
30
20
10
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
cms
Boys Height 22q11 DS and WHO Centiles
Birth to 5 years
120
WHO p91
22q p91
WHO p75
22q p75
WHO p50
22q p50
WHO p25
22q p25
WHO p9
22q p9
110
100
90
80
70
60
50
40
0
1
2
3
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
4
5
cms
190
Boys height 22q11 DS and reference (R) Birth to 20 years
R p91
22q p91
R p75
22q p75
R p50
22q p50
R p25
22q p25
R p9
22q p9
180
170
160
150
140
130
120
110
100
90
80
70
60
50
40
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
Girls Height 22q11 DS and WHO Centiles
Birth to 5 years
cms
120
WHO p91
22q p91
WHO p75
110
22q p75
WHO p50
22q p50
WHO p25
100
22q p25
WHO p9
22q p9
90
80
70
60
50
40
0
1
2
3
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
4
5
Girls Height 22q11 DS and Reference Centiles Birth to 20 years
cms
180
R 91
22q p91
R 75
22q p75
R 50
22q p50
R 25
22q p25
R9
22q p9
170
160
150
140
130
120
110
100
90
80
70
60
50
40
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
Boys BMI 22q11 DS and Reference Centiles Birth to 20 years
kg/m2
32
R p91
30
22q
p91
28
R p75
26
22q
p75
R p50
24
22q
p50
22
R p25
20
22q
p25
R p9
18
22q p9
16
14
12
10
2
3
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
kg/m2
Girls BMI 22q11 DS and Reference (R) Birth to 20 years
32
R p91
22q
p91
30
R p75
28
22q
p75
26
R p50
24
22q
p50
R p25
22
22q
p25
R p9
20
22q p9
18
16
14
12
2
3
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
Boys Head Circumference 22q11DS and WHO centiles
Birth to 5 years
cms
54
WHO p91
22q p91
WHO p75
22q p75
WHO p50
22q p50
WHO p25
22q p25
WHO p9
22q p9
52
50
48
46
44
42
40
38
36
34
32
30
0
1
2
3
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
4
5
Boys Head Circumference 22q11 DS and Reference (R) Birth to 20 years
kg/m2
60
58
56
54
R 91p
22q p91
R 75p
22q p75
R 50p
22q p50
R p25
22q p25
R p9
22q p9
52
50
48
46
44
42
40
38
36
34
32
30
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Age (years)
Arrow at disjunction between WHO and UK Reference values for head circumference
CHOP-GOSH Growth charts for 22q11 deletion syndrome
Girls Head Circumference 22q11 DS and WHO
Birth to 5 years
cms
WHO p91
22q p91
WHO p75
22q p75
WHO p50
22q p50
WHO p25
22q p25
WHO p9
22q p9
52
50
48
46
44
42
40
38
36
34
32
30
0
1
2
3
Age (years)
CHOP-GOSH Growth charts for 22q11 deletion syndrome
4
5
cms
Girls Head Circumference 22q11 DS and Reference Birth to 20 years
R p91
22q p91
R p75
22q p75
R p50
22q p50
R p25
22q p25
58
56
54
52
50
48
46
44
42
40
38
36
34
32
30
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Age (years)
Arrow at disjunction between WHO and UK Reference values for head circumference
CHOP-GOSH Growth charts for 22q11 deletion syndrome