Kansainvälinen syöpäsairauksien luokittelu ICD-O-3
Transcription
Kansainvälinen syöpäsairauksien luokittelu ICD-O-3
Kansainvälinen syöpäsairauksien luokittelu Kolmas laitos ICD‐O‐3 Toimittajat April Fritz Constance Percy Andrew Jack Kanagaratnam Shanmugaratnam Leslie Sobin D. Max Parkin Sharon Whelan World Health Organization Geneva Kansainvälinen syöpäsairauksien luokittelu Kolmas laitos ICD‐O‐3 Toimittajat April Fritz National Cancer Institute, Bethesda, MD, USA Constance Percy National Cancer Institute, Bethesda, MD, USA Andrew Jack Leeds Teaching Hospitals, Leeds, England Kanagaratnam Shanmugaratnam National University of Singapore, Singapore Leslie Sobin Armed Forces Institute of Pathology, Washington, DC, USA D. Max Parkin International Agency for Research on Cancer, Lyon, Franc Sharon Whelan International Agency for Research on Cancer, Lyon, France World Health Organization Geneva Published by the World Health Organization in 2000 under the title International Classification of Diseases for Oncology, 3rd edition (ICD-O-3) © World Health Organization 2000 The Director General of the World Health Organisation has granted translation rights for an edition in Finnish to the Cancer Society of Finland, which is solely responsible for the Finnish edition. Alustava alkuosan käännös: Heli Mäntyranta Suomenkielisen laitoksen toimituskunta: Risto Sankila Minna Merikivi Susanna Mustonen Irma Ovaska Suomen Syöpäyhdistyksen julkaisuja nro 75 ISBN 978 952 5815 00 9 Painopaikka: Multiprint, Helsinki 2008 SISÄLLYSLUETTELO Suomenkielisen painoksen esipuhe Omistuskirjoitus Calum Muirille Kiitokset v vii viii Johdanto Historiallinen tausta 1 3 ICD-O:n ja ICD-10:n väliset erot ICD-O 3. laitoksen rakenne ja esitystapa 5 9 Topografian ja morfologian koodausohjeet Tiivistelmä: ICD-O-3 koodauksen perussäännöt Topografian koodausohjeet Morfologian koodausohjeet Multippelit primaarikasvaimet Diagnoosiperuste WHO:n keskushermoston kasvainten pahanlaatuisuusasteikko ja ICD-O-3:n erilaistumiskoodi Lähdeluettelo 21 22 25 30 39 43 Numeeriset luettelot Topografia Kasvainten käyttäytymiskoodi (5. merkki) Histologisen erilaistumisasteen koodi (6. merkki) Lymfoomien ja leukemioiden immunofenotyypin ilmaisemisen koodi (6. merkki) Morfologia 49 50 72 73 44 46 73 75 Aakkosellinen hakemisto Alphabetic Index 111 134 Liitteet 1: Uudet ICD-O-3 koodit 2: Uudet morfologiatermit ja synonyymit 3: Termit, joiden ICD-O -koodinumero muuttui 4: Termit, jotka muuttuivat kuvaamaan kasvainta 5: ICD-O-3:sta poistetut termit 6: Termit, joiden käyttäytymiskoodi muuttui 239 247 255 258 258 259 iii Suomenkielisen laitoksen esipuhe Olemme kääntäneet tämän kansainvälisen syöpätautien luokittelun kolmannen laitoksen suomeksi, jotta edesauttaisimme terveydenhuoltojärjestelmämme ajanmukaistamista. Tämä kirja on saatavissa ilmaiseksi Suomen Syöpäyhdistyksestä, joka sen on kustantanut. Siirrämme tiedot myös Stakesin koodistopalvelimelle, jotta ohjelmistojen kehittäjät voivat hyödyntää niitä sähköiseen sairauskertomusarkistoon liittyvissä toimissa. Tausta-ajatuksenamme on, että näin saisimme myös lakisääteisen ns. kliinisen syöpärekisteri-ilmoituksen näiden sähköisten dokumenttien osaksi. Suomen Syöpärekisteri on toukokuussa 2008 siirtynyt käyttämään ICD-O-3 -luokittelua. Olimme luultavasti maailman viimeinen syöpärekisteri, joka menestyksekkäästi käytti 1950luvulta peräisin olevaa ICD-7 -luokitusta ja yhtä vanhaa histologista syöpien luokitusta. Juuri tällä hetkellä ICD-O-3 -koodit vastaavat SNOMED:in syöpäluokittelua. Samoin ICD-O-3 -koodit seuraavat World Health Organisation Classification of Tumours -kirjasarjassa määriteltyjä sairauksia. Emme suomentaneet morfologia-osaa. Läheskään kaikkia termejä ei ole koskaan käännetty, ja vaikka olisikin, ei niitä kukaan ymmärtäisi, koska patologit käyttävät sujuvasti nopeasti uudistuvaa, kansainvälistä, englanninkielistä terminologiaa. Helsingissä 24.10.2008 Risto Sankila Minna Merikivi Susanna Mustonen Irma Ovaska Suomen Syöpärekisteri Suomen Syöpäyhdistys v Omistettu CALUM MUIRille 1930 – 1995 Tämä kansainvälisen syöpäsairauksien luokittelun 3. laitos (ICD-O-3) on omistettu tohtori Calum Muirille. Calum Muir oli yksi edellisen ICD-O-2:n toimittajista. Patologina hän pääosin kokosi uudet morfologiatermit ja tuoreimmat lymfoomien, leukemioiden ja aivokasvainten luokittelut. Hänen erinomaisten syöpärekisteriyhteyksiensä ansiosta ICD-O saatiin käyttöön kaikkialla maailmassa. Hän toimi WHO:n Kansainvälisen syöväntutkimuskeskuksen (International Agency for Research on Cancer, IARC) Epidemiologisen yksikön johtajana ja sittemmin koko laitoksen apulaisjohtajana. Jäätyään eläkkeelle IARC:stä Calum Muir ryhtyi Skotlannin syöpärekisterin johtajaksi. Hänen panoksensa oli ratkaiseva kun kansainvälinen syöpärekisterijärjestö (International Association of Cancer Registries) perustettiin vuonna 1966. Hän toimi järjestön pääsihteerinä vuodet 1972 1990 ja presidenttinä vuodesta 1992 kuolemaansa asti. Calum Muirin henki ja hänen omistautuneisuutensa kasvainten täsmälliselle ja kattavalle luokittelulle elää edelleen tämän laitoksen myötä. vii KIITOKSET Toimittajat ovat kiitollisia seuraaville henkilöille ja heidän laitoksilleen panoksesta ICD-O-3:n toimitusprosessin yhteydessä. Dr Timothy Coté, National Cancer Institute, Bethesda, MD, USA Mme Catherine Exbrayat, Registre des Cancers de l’Isère, Isère, France Professor Ekkehard Grundmann, Gerhard Domagk Institut für Pathologie, Münster Universität, Münster, Germany Professor Paul Hermanek, Chirurgische Klinik mit Poliklinik der Universität Erlangen-Nürnberg, Erlangen, Germany Dr Elaine Jaffe, National Cancer Institute, Bethesda, MD, USA Dr Paul Kleihues, International Agency for Research on Cancer, Lyon, France Dr Franco Rilke, Società Italiana di Cancerologia, Milan, Italy Dr James Vardiman, University of Chicago, Chicago, IL, USA Mrs Annette Hurlbut, Fulton, NY, USA Toimittajat ovat kiitollisia asiantuntijaryhmille, jotka tuottivat arvokasta taustamateriaalia ICD-O-3:n valmistelutyötä varten ja kommentoivat testiversiota: European Network of Cancer Registries (ENCR) Working Group on the coding of haematological malignancies and lymphomas Dr Renée Otter, Comprehensive Cancer Centre North, Groningen, The Netherlands Dr Aurora Astudillo, Hospital General de Asturias, Oviedo, Spain Professor Paule Marie Carli, Registre des Hémopathies Malignes en Côte d'Or, Dijon, France Dr Andrew Jack, Leukaemia Research Fund, University of Leeds, Leeds, England Dr Han Van Krieken, The Academic Hospital, Leiden, The Netherlands International Society of Pediatric Oncology (SIOP) Working Group Professor Jillian M. Birch, CRC Paediatric and Familial Cancer Research Group, Manchester, England Dr James Ironside, National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, Scotland Dr Anna M. Kelsey, Royal Manchester Children’s Hospital, Manchester, England Professor Dietmar Schmidt, Institut für Pathologie, Mannheim, Germany viii Toimittajat ovat kiitollisia seuraaville syöpärekistereille ja niiden patologeille ja tiedon kerääjille siitä suuresta työmäärästä, joka käytettiin ICD-O-3:n testiversion hyväksi: Australia, New South Wales Australia, South Australia, Victoria Belarus Belgium Brazil, Campinas Brazil, Porto Alegre Canada, British Columbia Canada, Manitoba Canada, Ontario Canada, Ontario, Princess Margaret Hospital Canada, Nova Scotia China, Beijing China, Qidong Cuba Czech Republic Ecuador, Quito Egypt, Alexandria France, Haut-Rhin France, Hémopathies Malignes, en Côte d’Or France, Hérault France, Tarn Germany, BadenWürttemberg Germany, Federal States of Berlin Germany, National Childhood Guinea, Conakry Indonesia Italy, Ferrara Italy, Macerata Italy, Ragusa Italy, Romagna Japan, Hiroshima Japan, Nagasaki Japan, Osaka Lithuania Malta Netherlands, Amsterdam New Zealand Pakistan, Karachi Peru, Lima Peru, Trujillo Philippines, Manila Philippines, Rizal Poland, Kielce Saudi Arabia Singapore Slovenia South Africa Spain, Asturias Spain, Granada Spain, Mallorca Spain, Murcia Sweden, Gothenburg Thailand, Bangkok Thailand, Chiang Mai Trinidad and Tobago Uganda, Kampala United Kingdom, East Anglia United Kingdom, Northern and Yorkshire United Kingdom, Oxford, National Childhood USA, Florida, Flagler Hospital USA, Georgia, Medical Center of Central Georgia USA, Missouri, Liberty Hospital USA, Ohio, Upper Valley Medical Center USA (SEER), Atlanta USA (SEER), Connecticut USA (SEER), Detroit USA (SEER), Hawaii USA (SEER), Iowa USA (SEER), Los Angeles USA (SEER), New Mexico USA (SEER), Northern California USA (SEER), Seattle/Puget Sound USA (SEER), Utah USA, Texas, College Station Medical Center Viet Nam, Ho Chi Minh Toimittajat ovat kiitollisia niille monille henkilöille, laitoksille ja syöpärekistereille, jotka täyttivät kansainvälisen syöpärekisteriyhdistyksen kyselyn ja tarjoutuivat osallistumaan ICD-O-3:n testiversion koekäyttöön. ix JOHDANTO Syöpäsairauksien kansainvälistä tautiluokitusta International Classification of Diseases for Oncology (ICD-O) (1) on käytetty vuodesta 1976 lähtien, pääasiassa syöpärekistereissä. Sen avulla on koodattu syövän sijainti (topografia) ja histologia (morfologia), jotka yleensä on saatu patologin lausunnosta. College of American Pathologists -yhdistyksen kanssa solmitun sopimuksen perusteella ICD-O:n morfologialuokitus on liitetty Systematized Nomenclature of Medicine (SNOMED) -luokitukseen (2, 3). International Classification of Diseases for Oncology, Second Edition (4), jonka toimittivat Constance Percy, Valerie Van Holten ja Calum Muir, julkaistiin vuonna 1990. Nyt käsillä olevan, 3. laitoksen topografiaosa on sama kuin 2. laitoksen, joka perustuu ICD-10:n (5) neoplasmoja käsittelevään osaan. Morfologiaosa on kuitenkin uudistettu. Erityisesti lymfoomille ja leukemioille on luotu uudet luokitukset ja tämän vaatimat uudet koodit. Vuonna 1994 otettiin käyttöön REAL-luokitus (Revised European–American Lymphoma) (6) ja non-Hodgkin-lymfoomien rekisteröintiä varten tarvittiin ICD-O-koodit. Samoin leukemioita varten otettiin käyttöön FAB (French–American–British) -järjestelmän (7) termit. Kun ICD-O-työryhmä kokoontui vuonna 1998, suunniteltiin vain näiden kahden osan uudistamista, mutta lopulta päätettiin käydä läpi koko julkaisu. ICD-O:n morfologiaosan 3. laitoksen kenttätestaus tehtiin vuonna 1999. Esitämme kiitoksemme kaikille niille rekistereille eri puolilla maailmaa, jotka ovat kommentoineet tämän laitoksen sisältöä. Vaikka kirjan toimittajien tärkeimpiin ohjenuoriin on kuulunut, että termejä muutettaisiin mahdollisimman harvoin, tyhjiin kohtiin lisättäisiin uusia termejä ja aikaisemmin käyttöön otettuja numerokoodeja ei käytettäisi uudelleen, tämä ei aina ole ollut mahdollista. Jotta samantapaiset sairausryhmät voitaisiin pitää yhtenäisinä, joidenkin morfologioiden koodeja oli pakko muuttaa. Lisäksi termien järjestys tai ryhmittely ei aina ehkä ole mahdollisimman looginen, koska koodinumeroita on vain rajallinen määrä. ICD-O:n edellisiä laitoksia ja tätä laitosta laadittaessa on erityisesti pyritty käyttämään Maailman terveysjärjestön Histological Classification of Tumours -sarjan (WHO:n ”sinisten kirjojen”) (8) nimityksiä. Tämä sarja kattaa kaikki syövän esiintymispaikat, ja siinä on kullekin sairaudelle annettu ICD-O:n 2. laitoksessa käytetty morfologiakoodi. Toisen laitoksen ilmestymisen jälkeen lisätyt uudet morfologiatermit on lueteltu kirjan lopussa. Refraktorista anemiaa ja muita myelodysplastisia oireyhtymiä pidetään nyt pahanlaatuisina; niiden malignanssiluokitus (behavior code) on siksi muutettu: kun se ennen oli /1 (hyvän- tai pahanlaatuisuus epäselvää), se on nyt /3 (pahanlaatuinen). Mahdollisesti pahanlaatuisiksi katsottavat munasarjojen (borderline) kystadenoomat, jotka ICD-O:n 2. laitoksessa oli koodattu pahanlaatuisiksi, on 3. laitoksessa merkitty koodilla /1. Jotta pitkittäistietokannoissa säilyisi johdonmukaisuus, suosittelemme, että kaikki munasarjojen (borderline) kystadenoomat koodataan uudelleen koodilla /1 tai poistetaan tietokannasta. Taulukko 1. Kasvainten koodaus 1946-2000: ICD-O:n tausta Pääosin topografia Pääosin morfologia 9 ICD‐6 1948 WHO MOTNAC Topografia ja morfologia 19 10 1951 ACS SNDO 4. laitos 1951 5. laitos 1961 AMA 11 13 SNOP 1965 Osat 8, 9 Kasvaimet CAP ICD‐7 1955 WHO 15 ICDA‐8 1967 USA 12 14 16 H‐ICDA‐8 1968 USA ICD‐8 1967 WHO Luku II Kasvaimet MOTNAC 1968 ACS 18 ICD‐9 1975 WHO 1 Luku II Kasvaimet ICD‐O 1976 WHO Luku II Kasvaimet ICD‐O Toinen laitos 1990 WHO 17 ICD‐9‐CM 1979 CPHA 5 ICD‐10 1992 WHO 2 SNOMED Morfologia Kasvaimet 1977 CAP 4 3 SNOMED III (Kansainvälinen) Kasvaimet 1993 CAP Huom. Ruuduissa olevat numerot viittaavat lähdeluetteloon s.46. 2 ICD‐O Kolmas laitos 2000 WHO 20 SNOMED RT 2000 CAP HISTORIALLINEN TAUSTA Kuolinsyille on ollut olemassa kansainvälinen luokitus vuodesta 1893. Kun toisen maailmansodan jälkeen perustettiin Yhdistyneet Kansakunnat ja Maailman terveysjärjestö (WHO), ne ottivat huolekseen tämän luokituksen julkaisemisen. International Statistical Classification of Diseases, Injuries, and Causes of Death (ICD) -luokituksen 6. laitos (9) julkaistiin vuonna 1948, ja pian sen jälkeen sitä alettiin kuolinsyiden luokittelun lisäksi käyttää myös sairauksien luokittelussa. Kasvainten luokittelun ja koodauksen alkuvaiheissa (1950- ja 1960-luvuilla) tärkein sairauksien luokittelujärjestelmä oli WHO:n julkaisema ICD-sarja. Ajan myötä ICD:tä alettiin käyttää koodattaessa ja taulukoitaessa potilastietojen diagnooseja arkistoinnin ja hakujen helpottamiseksi, ja ICD:n 2. luku sisälsi aina kasvainten luokituksen. ICD:n 6. laitoksen julkaisemisen jälkeen eli vuodesta 1948 kasvainten luokitus on pääasiassa perustunut niiden sijaintiin ja käyttäytymiseen (pahanlaatuinen, hyvänlaatuinen tai ei määritelty). Imukudos- ja hematopoeettisia kasvaimia, koriokarsinoomaa, melanoomaa ja tiettyjä hyvänlaatuisia kasvaimia lukuun ottamatta histologisille tyypeille ei ollut olemassa koodattua nimistöä. Ensimmäisen kasvainten morfologiaa käsittelevän koodauskäsikirjan julkaisi American Cancer Society (ACS) vuonna 1951. Sen nimi oli Manual of tumor nomenclature and coding (MOTNAC) (10). Sen koodeissa morfologia ilmaistiin kahdella numerolla ja kasvaimen käyttäytyminen kolmannella. Tämä koodi toimi perustana, kun WHO vuonna 1956 esitti kasvainten morfologian koodaamista tilastointia varten. 1960-luvulla College of American Pathologists (CAP) päätti kehittää kaikki patologiset entiteetit käsittävän luokituksen. ACS:n avulla CAP julkaisi teoksen Systematized nomenclature of pathology (SNOP) (11). SNOP sisälsi morfologiakoodiston, jossa oli kaksi kasvaimia koskevaa lukua (8 ja 9), sekä täysin uuden, erittäin yksityiskohtaisen topografiakoodiston, joka kattoi koko ihmisruumiin. Järjestöjen välisessä sopimuksessa todettiin, että ACS voisi käyttää SNOP:n kasvainmorfologian lukuja 8 ja 9 ja julkaista ne yhdessä omien topografiakoodiensa kanssa. Koska syöpien rekisteröinnissä oli topografiakoodit aina otettu ICD:n pahanlaatuisten kasvainten luvusta, ACS käytti pahanlaatuisten kasvainten topografiaa käsittelevien lukujen pohjana ICD-8:aa. MOTNAC:sta ilmestyi uusi laitos vuonna 1968 (12), ja sitä käytettiin syöpärekistereissä laajasti. Vuonna 1968 WHO pyysi Kansainvälistä syöväntutkimuskeskustaan (International Agency for Research on Cancer, IARC) esittämään suosituksia ICD-9:n kasvainluvun sisällöstä ja rakenteesta, yhdessä WHO:n syöpä- ja ICD-osastojen ja useiden kansallisten tahojen kanssa. Lääkärit toivoivat syöpää koskevaa lisäosaa, jossa olisi mukana myös morfologia. Monet asiantuntijat eri puolilta maailmaa esittivät ehdotuksia ICD9:n kasvainlukujen laadinnasta; he korostivat, että morfologia tai histologia oli tarpeen koodata. He esittivät, että morfologia- (histologia-)osan pohjana voitaisiin käyttää MOTNAC:n vuonna 1968 ilmestynyttä laitosta. Se perustui CAP:n vuonna 1965 julkaiseman SNOP:n kasvainosaan. MOTNAC oli laajassa käytössä ja se oli käännetty usealle kielelle. 3 ICD-9:n työryhmät suosittelivat myös, että kasvaimen morfologia tulisi kirjata ja koodata. Jo vuosien ajan onkologit olivat ymmärtäneet, ettei kasvaimen sijaintitieto yksin riittänyt hoidon suunnittelemiseen tai tutkimuksen tekoon. Esimerkiksi ilmaantuvuus ja elossaololuvut vaihtelevat kasvaimen histologisen tyypin mukaan. Edelleen työryhmät esittivät, että MOTNAC:n jatkoksi luotaisiin ICD:n erikoisversio, jonka nimeksi tulisi International Classification of Diseases for Oncology (1) ja jota käyttäisivät yksityiskohtaisempaa histologista luokitusta tarvitsevat onkologiaspesialistit. Vuonna 1971 WHO:n tautiluokituksen erityistyöryhmä yhtyi tähän suositukseen. Työn pohjaksi tarkastelluista vaihtoehdoista yksi oli suuren suosion saanut MOTNAC:n vuoden 1968 laitos. Vuonna 1976 WHO julkaisi International Classification of Diseases for Oncology -luokituksen 1. laitoksen. Siihen sisältyi topografinen osa, joka perustui ICD-9:n pahanlaatuisten kasvainten nimikkeisiin, sekä morfologinen osa, jossa MOTNAC:n morfologisia koodeja oli laajennettu yhdellä merkillä. CAP sisällytti ICD-O:n morfologisen osan SNOP:n uuteen laitokseen, jonka nimi oli Systematized Nomenclature of Medicine (SNOMED) (2). SNOMED:n topografinen osa taas oli täysin erilainen kuin ICD-O:n. Eräitä SNOMED:n morfologisia termejä, jotka koskevat esimerkiksi kasvaimen kaltaisia muutoksia tai esiasteita, on otettu mukaan ICD-O:hon, jotta käyttäjän olisi helpompi erottaa nämä ilmiöt aidoista kasvaimista. SNOMED:n koodeja ei enää ole sisällytetty julkaisuun, koska ne vaihtuvat jatkuvasti ja ne julkaistaan nykyään pääasiallisesti verkossa. ICD-O:n käyttäjän ei tarvitse tietää muuta kuin se, että SNOMED:iin viittaava termi ei tarkoita rekisteröitäviä kasvaimia. International Classification of Diseases for Oncology -luokituksen 2. laitos (4) laadittiin WHO:n ja IARC:n yhteisessä työryhmässä, ja sen toimittivat Constance Percy, Valerie Van Holten ja Calum Muir. WHO julkaisi sen vuonna 1990 käytettäväksi syöpärekistereissä ja muissa syöpään erikoistuneissa yksiköissä. Se on luokitusja koodausjärjestelmä, joka ottaa huomioon sekä kasvaimen sijainnin että rakenteen. Topografiakoodissa käytetään samoja kolmen ja neljän merkin kategorioita kuin ICD10:ssä luokittelemaan pahanlaatuisia kasvaimia (C00-C80), joten ei-pahanlaatuisten kasvainten paikka on mahdollista luokitella tarkemmin kuin ICD-10:n avulla. ICDO:n 2. laitosta on käytetty laajasti kaikkialla maailmassa, ja se on käännetty ainakin espanjan, italian, japanin, kiinan, kreikan, portugalin, ranskan, saksan, slovakin, tsekin ja venäjän kielille. Käsillä olevan ICD-O:n 3. laitoksen on laatinut IARC:n ja WHO:n kokoon kutsuma työryhmä. Morfologialuokittelu on uusittu erityisesti lymfoomien ja leukemioiden osalta. Koodit vastaavat WHO-luokitusta (21, 22), joka korvasi lymfoomien REAL (Revised European-American Lymphoma) -luokituksen (6) ja leukemioiden FAB (French-American-British) -luokituksen (7). Kolmannessa laitoksessa on myös otettu huomioon myelooisten leukemioiden WHO-luokitus, johon sisältyvät erilliset morfologian ja sytogeneettisten epänormaaliuksien yhdistelmät, esimerkiksi M-9875/3, ”krooninen myelooinen leukemia, Philadelphia-kromosomi (Ph1) positiivinen”, josta käytetään myös nimityksiä ”krooninen myelooinen leukemia (t(9;22)(q34;q11)” tai ”krooninen myelooinen leukemia, BCR/ABL”. 4 Muunnokset ICD-O:n 3. laitoksen muunnosalgoritmit (vertailukoodit) ovat saatavilla. Muunnos ICD-10:een julkaistaan sekä sähköisenä että painettuna versiona. Kuten yllä on mainittu, ICD-O:n 2. ja 3. laitoksen välillä ei topografiassa ole tapahtunut muutosta, ja morfologiaosan tärkeimmät muutokset koskevat lymfoomia ja leukemioita. ICD-O:N JA ICD-10:N VÄLISET EROT ICD-O:n ja ICD-10:n rakenteissa on tiettyjä peruseroja. ICD-10:n II luvussa (Kasvaimet) kuvataan kasvaimen käyttäytymistä (pahanlaatuinen, hyvänlaatuinen, in situ tai pahan-/hyvänlaatuisuudeltaan epävarma) topografiakoodilla siten, että kullekin käyttäytymistavalle on annettu tietty koodi. Siksi ICD-10:ssä tarvitaan viiteen eri luokkaan kuuluvat neljän merkin pituiset koodit kuvaamaan kaikkia keuhkokasvaimia (kts. taulukko 2). ICD-10:ssä on määritelty vain muutama histologinen tyyppi. ICD10:ssä ei esimerkiksi ole mahdollista erottaa toisistaan keuhkojen adenokarsinoomaa ja keuhkojen levyepiteelikarsinoomaa vaan molempien koodi on C34.9. ICD-10:n aakkosellinen hakemisto (osa 3) sisältää hakusanan ”kasvain” alla viisisarakkeisen taulukon, jossa on seuraavat otsikot: pahanlaatuinen, sekundaarinen tai metastaattinen, in situ, hyvänlaatuinen, epävarma ja tuntematon käyttäytyminen. Tämän jälkeen on lueteltu aakkosjärjestyksessä kutakin ruumiinosaa koskevat ICD10-luokat. Taulukossa 2 on esitetty esimerkkinä keuhkokasvaimet. Taulukko 2. ICD-10:n aakkosellisen hakemiston hakusana ”keuhkokasvaimet” Keuhko Pahanlaatuinen Sekundaarinen tai metastaattinen In situ C34.9 C78.0 D02.2 Hyvänlaatuinen D14.3 Epävarma ja tuntematon D38.1 ICD-O:ssa sen sijaan topografia merkitään vain yhdellä neljän merkin koodilla (joka perustuu ICD-10:n pahanlaatuisia kasvaimia käsittelevään osaan); samassa paikassa esiintyvien kasvainten topografiakoodi (C34.9, keuhko) on aina sama. Käyttäytymiskoodi (behavior), joka on morfologiakentän viides merkki, osoittaa kasvaimen malignanssin eli hyvän- tai pahanlaatuisuuden. (Kts. Käyttäytyminen, s. 30.) ICDO:ssa kuvataan myös kasvaimen tyyppi tai morfologia siten kuin taulukossa 3 on esitetty, esim. keuhkojen adenokarsinooman koodi on C34.9, M-8140/3 ja keuhkojen levyepiteelikarsinooman koodi C34.9, M-8070/3. 5 Taulukko 3. ICD-O-3:n keuhkokasvaimia koskevat koodit Pahanlaatuinen keuhkokasvain (esim. karsinooma) C34.9 M-8010/3 Metastaattinen keuhkokasvain (esim. kiveslähtöinen seminooma) C34.9 M-9061/6 In situ -keuhkokasvain (esim. in situ –levyepiteelikarsinooma) C34.9 M-8070/2 Hyvänlaatuinen keuhkokasvain (esim. adenooma) C34.9 M-8140/0 Käyttäytymiseltään epävarma keuhkokasvain (esim. käyttäytymiseltään epävarma karsinoidi) C34.9 M-8240/1 Taulukossa 4 on esitetty, miten ICD-O:n käyttäytymiskoodi vastaa ICD-10:n II luvun eri osia. Taulukko 4. ICD-O-3:n käyttäytymiskoodi ja ICD-10:n II luvun vastaava jakso Käyttäytymiskoodi Luokka Termi /0 /1 D10-D36 D37-D48 /2 /3 D00-D09 C00-C76, C80-C97 /6 C77-C79 Hyvänlaatuiset kasvaimet Käyttäytymiseltään epävarmat ja tuntemattomat kasvaimet In situ -kasvaimet Pahanlaatuiset kasvaimet, jotka on mainittu tai jotka otaksutaan primaareiksi Pahanlaatuiset kasvaimet, jotka on mainittu tai jotka otaksutaan sekundaarisiksi ICD-10:n julkaisemiseen asti oli käytössä vain kolme pahanlaatuisten kasvainten histologista tyyppiä, joilla oli omat luokat: lymfooma, leukemia ja ihomelanooma. ICD-10:een lisättiin useita uusia, histologisiin tyyppeihin perustuvia luokkia, joista merkittävimmät ovat mesoteliooma (C45) ja Kaposin sarkooma (C46). Lisäksi maksasyöpä (C22) jaettiin ”alatyyppeihin”, jotka perustuivat histologisiin ryhmiin. ICD-10:n luokat, joita ei esiinny ICD-O:n 3. laitoksessa Kuten edellä mainittiin, ICD-10:n luokista C00–C97 muutama joko perustuu morfologialle tai käsittelee sellaisia metastaattisia tai sekundaarisia kasvaimia, jotka ICDO:ssa on kuvattu käyttäytymiskoodilla. Taulukossa 5 on lueteltu ne ICD-10:n luokat, jotka eivät sisälly ICD-O:n topografiaosaan. ICD-10:n osaa C81–C96 käytetään lymfaattisten, hematopoeettisten ja vastaavien kudosten pahanlaatuisten kasvainten luokitteluun. ICD-O:n 3. laitoksessa näille on annettu omat morfologiakoodit sekä käyttäytymiskoodi /3. Koko diagnoosi voidaan ilmaista väliltä C00–C80 valitun topografiakoodin ja morfologiakoodin avulla. Esimerkkinä olkoon mahalaukun lymfosyyttinen lymfooma, jonka koodi ICD-10:ssä on C83.0. 6 Taulukko 5. ICD-10:n termit, joita ei ole ICD-O:ssa ICD-10 Vastaava koodi ICD-O:n 3. laitoksessa Luokka Termi Paikka Histologia C43 Ihomelanooma C44._ M-872-M-879 /3 C45 Mesoteliooma C__._ M-905 /3 C46 C81-C96 Kaposin sarkooma Lymfoidisten, hematopoeettisten ja niihin liittyvien kudosten pahanlaatuiset kasvaimet Hengitys- ja ruuansulatuselimistön sekundaariset pahanlaatuiset kasvaimet Muiden määriteltyjen paikkojen sekundaariset pahanlaatuiset kasvaimet C ___ ._ M-9140 /3 C00-C80 M-959-M-998 /3 C15-C39 M-______ /6 C00-C14, C40-C80 M-______ /6 D00-D09 In situ -kasvaimet C00-C80 M-______ /2 D10-D36 D37-D48 Hyvänlaatuiset kasvaimet Käyttäytymiseltään epävarmat ja tuntemattomat kasvaimet Multippelien primaaripaikkojen pahanlaatuiset kasvaimet C00-C80 M-______ /0 C00-C80 koodataan kukin erikseen M-______ /1 C78 C79 C97 Käyttäytyminen /3 ICD-O:ssa pienisoluisen (diffuusin) non-Hodgkin-lymfooman paikaksi koodataan mahalaukku: C16.9, ja morfologiaksi M-9670/3 (diffuse small cell lymphoma). ICD-O:ssa ei ole ICD-10:n luokkaa C97, koska kukin primaaripaikka koodataan yleensä erikseen. Lisäksi eri maissa ohjeet multippelisyöpien lähtöpaikan määrittelyissä vaihtelevat. ICD-O:n erityiskoodit imusolmukkeiden (C77) ja hematopoeettisen ja retikuloendoteliaalisysteemin (C42) topografioille ICD-10:ssä luokan C77 avulla luokitellaan imusolmukkeiden sekundaariset ja epäspesifit pahanlaatuiset kasvaimet. ICD-O:ssa koodia C77 käytetään imusolmukkeiden topografiakoodina. Täten useimmat ICD-10:n pahanlaatuiset lymfoomat (C81– C85) saavat ICD-O:ssa topografiakoodin C77. ICD-10:ssä ei käytetä luokkaa C42, mutta ICD-O:ssa sitä käytetään hematopoeettisen ja retikuloendoteliaalisysteemin topografioiden luokitteluun. Näillä C42-topografiakoodeilla ilmoitetaan pääasiassa useimpien ICD-10:ssä luokkiin C90–C95 määriteltyjen leukemioiden ja vastaavien tilojen paikka. Taulukossa 6 on lueteltu ICD-O:ssa käytetyt C42-alaluokat. 7 Esimerkiksi kroonisen lymfosyyttisen leukemian luokka ICD-10:ssä on C91.1. ICDO:ssa sen koodi on topografiakoodi C42.1 (luuydin) ja morfologiakoodi M-9823/3 (B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma). ICD-10:ssä käytettyä pernan pahanlaatuisen kasvaimen luokkaa (C26.1) ei esiinny ICD-O:n 3. laitoksen kohdassa ruuansulatuselimistö. ICD-O:n 1. laitoksessa omaksutun käytännön mukaisesti perna koodataan hematopoeettisen ja retikuloendoteliaalisysteemien topografioiden koodilla C42.2. Taulukko 6. ICD-O:n topografiakoodit, joita ei ole ICD-10:ssä C42 HEMATOPOEETTINEN JA RETIKULOENDOTELIAALIJÄRJESTELMÄ C42.0 Veri C42.1 Luuydin C42.2 Perna C42.3 Retikuloendoteliaalijärjestelmä, NOS C42.4 Hematopoeettinen järjestelmä, NOS Rypäleraskaus (hydatidiform mole) ja neurofibromatoosit (von Recklinghausenin tauti, ei luutauti) Edellä mainitun lisäksi ICD-O ja ICD-10:n II luku eroavat toisistaan siten, että hydatidiform mole, NOS (ICD-O:ssa C58.9 M-9100/0) ei ICD-10:ssä ole luokiteltu II lukuun (Kasvaimet), vaan lukuun XV "Raskaus, synnytys ja lapsivuodeaika" (luokka O01.9, määrittämätön rypäleraskaus), ja neurofibromatoosi, johon sisältyy (muu kuin luun) von Recklinghausenin tauti (ICD-O:ssa M-9540/1) sisältyy XVII lukuun "Synnynnäiset epämuodostumat, epämuotoisuudet ja kromosomipoikkeavuudet" luokkana Q85.0. HIV ja AIDS Ihmisen immuunikatoviruksen (HIV) aiheuttaman taudin yhteydessä esiintyvät pahanlaatuiset kasvaimet ovat herättäneet suurta kiinnostusta. Nämä kasvaimet tulee koodata tämän käsikirjan sääntöjen mukaan. Niihin liittyvä AIDS koodataan erilliseen kenttään. Toiminnalliset kasvaimet ICD-O:ssa ei yleensä ole koodeja kasvainten toiminnalle, esimerkiksi pahanlaatuisen feokromosytooman (C74.1, M-8700/3) katekoliamiinituotannolle. Kasvainten toimintaa voidaan koodata käyttämällä esimerkiksi ICD-10:n IV luvun ”Umpierityssairaudet, ravitsemussairaudet ja aineenvaihduntasairaudet” koodeja. Esimerkin katekoliamiinituotanto merkittäisiin koodilla E27.5. 8 ICD-O 3. LAITOKSEN RAKENNE JA ESITYSTAPA ICD-O on kaksiosainen koodausjärjestelmä, jolla koodataan kasvaimen sijainti ja morfologia. Topografiakoodi kuvaa kasvaimen alkuperäpaikan ja siinä käytetään samoja 3- ja 4-merkkisiä pahanlaatuisten kasvainten luokkia kuin ICD-10:ssä (C00– C80), joten ei-pahanlaatuisten kasvainten sijainti voidaan koodata täsmällisemmin kuin ICD-10:ssä on mahdollista. Morfologiakoodilla kuvataan kasvaimen solutyyppi ja sen biologinen aktiivisuus, ts. kasvaimen ominaisuudet. ICD-O:ssa on viisi pääosaa: I. Käyttöohjeet Tähän osaan on tutustuttava huolellisesti. Siinä on käyttöohjeet sekä syöpärekistereissä ja patologian laboratorioissa noudatettavat sovellussäännöt. II. Topografia – Koodinumeroluettelo kts. Koodausohjeet III. Morfologia – Koodinumeroluettelo kts. Koodausohjeet IV. Aakkosellinen hakemisto V. Toisen ja kolmannen laitoksen morfologiakoodien erot Tässä osassa on lueteltu termit, jotka tässä laitoksessa katsotaan pahanlaatuisiksi, kaikki uudet morfologiakoodinumerot sekä kaikki entisiin koodimääritelmiin lisätyt termit ja synonyymit. Lyhenteet M — Morfologia NOS — Not Otherwise Specified (NUD, tarkemmin määrittämätön; kts. s. 13) ICD-O-3 — International Classification of Diseases for Oncology, 3. laitos Amerikkalainen ja brittiläinen oikeinkirjoitus Jotta eri maissa käytetyt erilaiset oikeinkirjoitusmuodot eivät aiheuttaisi toistoa, julkaisussa on käytetty amerikkalaista oikeinkirjoitusta, siis esimerkiksi ”leukemia” ja ”tumor” eikä brittiläiseen tapaan ”leukaemia” ja ”tumour”. Mainitut esimerkkisanat ovat joka tapauksessa aakkosjärjestyksessä toistensa lähellä. Jos oikeinkirjoitusero on sanan alussa, kuten sanassa ”esophagus” / ”oesophagus”, brittiläinen oikeinkirjoitusmuoto on otettu mukaan hakemistoon, mutta siitä viitataan amerikkalaiseen muotoon: ”Oesophagus (see Esophagus)”. Topografia - koodinumeroluettelo Taulukko 7. Topografiakoodin rakenne Topografiaa käsittelevä osa on muokattu ICD10:n II luvun osasta, joka käsittelee pahanlaatuisia kasvaimia. Näille topografiatermeille on annettu nelimerkkiset koodit, jotka alkavat C00.0:sta ja päättyvät C80.9:ään. Kolmimerkkisten luokkien alaluokka on erotettu pisteellä (.) kts. taulukko 7. 9 C__ __.__ paikka alapaikka Esimerkki C50.2 Rinta, ylempi sisäneljännes Morfologia – koodinumeroluettelo ICD-O:n 1. ja 2. laitoksen morfologiaa käsittelevä osa on uudistettu. Uusia termejä on lisätty ja non-Hodgkin-lymfoomaa ja leukemiaa koskevat osat on uudistettu WHO Classification of Hematopoietic and Lymphoid Diseases (21, 22) mukaan. Koodinumeroluettelosta käy ilmi morfologianimikkeistön ryhmittely ja sitä käytetään koodeista päättämiseen ja niiden tulkintaan. Morfologiaosan uudistustyössä on kaikin keinoin pyritty ottamaan mukaan tuoreessa kirjallisuudessa esiintyneet uudet termit. Useissa kohdin on otettu mukaan kasvaimia koskevia termejä useammasta kuin yhdestä luokittelujärjestelmästä, esimerkkinä pahanlaatuiset lymfoomat (M-959–M-971). Korostettakoon, että ICD-O on kasvainten koodinimistö - ei niiden luokittelujärjestelmä. Eri luokittelujärjestelmistä otettujen termien sisällyttäminen julkaisuun ei osoita erityistä minkään järjestelmän suosittelemista. Morfologiatermeille on Taulukko 8. Morfologiakoodin rakenne annettu viisimerkkiset __ __ __ __ / __ __ koodit väliltä histologia käyttäytyminen erilaistuminen M-8000/0–M-9989/3. Ensimmäiset neljä Esimerkki: hyvin erilaistunut adenokarsinooma merkkiä kuvaavat M-8140 / 3 1 kasvaimen täsmällisen histologisen tyypin (taulukko 8). Kauttaviivan (/) jälkeinen viides kasvain-/solutyyppi Käyttäytyminen Erilaistuminen merkki on käyttäyty[adeno-] [karsinooma] [hyvin erilaistunut] miskoodi, joka osoittaa, onko kasvain pahanlaatuinen, hyvänlaatuinen, in situ vai onko sen hyvän-/pahanlaatuisuus tuntematon (kts. s. 30). Käytettävissä on myös erillinen yhden merkin koodi, jolla merkitään histologinen erilaistuminen (kts. Erilaistuminen, s. 34). Lymfoomissa ja leukemioissa tällä koodilla määritetään T-, B-, NULL- ja NK-solulinja. Siten täydellisessä ICD-O-koodissa on 11 merkkiä, joilla merkitään paikka (4 merkkiä), morfologinen tyyppi (5 merkkiä), käyttäytyminen (1 merkki) ja kasvaimen erilaistuminen tai lymfoomissa ja leukemioissa sitä vastaava ominaisuus (1 merkki). Taulukossa 9 on esimerkki. 10 Taulukko 9. Koko koodin rakenne Diagnoositermi: Huonosti erilaistunut epidermoidikarsinooma, keuhkon ylälohko C34.1 M-8070/33 ICD-O-termien esitystapa koodinumeroluettelossa Kukin topografinen ja morfologinen termi esiintyy koodinumeroluettelossa vain kerran; tätä havainnollistetaan taulukossa 10. Tietyn koodin kohdalla esiintyvä lihavoitu termi on suositeltu termi. Taulukko 10. Koodinumeroluettelon esitystapa C07.9 Parotid gland Parotid, NOS Stensen duct Parotid gland duct M-8290/3 Oxyphilic adenocarcinoma Oncocytic carcinoma Oncocytic adenocarcinoma Hurthle cell carcinoma (C73.9) Hurthle cell adenocarcinoma (C73.9) Follicular carcinoma, oxyphilic cell (C73.9) Tässä esimerkissä ”korvasylkirauhanen” kuvaa kaikkia koodilla C07.9 merkittyjä tapauksia. Lihavointi osoittaa, että tämä on suositeltu (ensimmäinen) termi. Synonyymi eli ”korvasylkirauhanen, NOS” on sisennettynä lihavoidun termin alla. Sisentämättömiä termejä ”Stensenin tiehyt” ja ”korvasylkirauhasen tiehyt” kutsutaan ekvivalenteiksi termeiksi. Ne eivät ole suositellun termin (korvasylkirauhanen) synonyymeja, mutta ne on mainittu saman koodin yhteydessä, koska ne ovat ensin annetun termin topografisia alaluokkia eivätkä ole niin selvästi eroteltavissa, että ne saisivat oman koodin. Aakkosellisessa hakemistossa kaikille näille termeille on annettu koodi C07.9. Samalla tavoin morfologiatermi ”oxyphilic adenocarcinoma” kuvaa kaikkia koodilla M-8290/3 luokiteltuja morfologioita. ”Oncocytic carcinoma” ja ”oncocytic adenocarcinoma” ovat ”oksyfiilisen adenokarsinooman” toisia nimiä (synonyymeja), mutta ”Hurthle cell carcinoma”, ”Hurthle cell adenocarcinoma” ja ”follicular carcinoma, oxyphilic cell” (ekvivalentteja termejä) ovat muuntyyppisiä oksyfiilisiin soluihin liittyviä karsinoomia. Aakkosellinen hakemisto Aakkosellista hakemistoa käytetään sekä topografian (anatomisten sijaintipaikkojen) että morfologian (histologisten termien) koodaukseen. Hakemistoon sisältyy myös eräitä kasvaimia muistuttavia muutoksia ja tiloja. Topografiakoodien tunnisteena on C-kirjain, joka on ICD-10:n II luvun koodien ensimmäinen merkki. Morfologiakoodien tunnisteena on M-kirjain. Termit on aakkostettu sekä substantiivin että adjektiivin mukaan. Esimerkiksi ”basophil adenocarcinoma” on aakkostettu B:hen sanan ”basophil” mukaan ja A:han sanan ”adenocarcinoma” mukaan. Aakkosellisen hakemiston esitystapa ja käyttö Taulukossa 11 on esitetty aakkosellisen hakemiston ensimmäinen palsta. Kaikki sanat, jotka ovat osana vähintään kolmessa termissä, on lihavoitu (esim. ”Abdomen”, ”Abdominal” ja ”Abdominal wall”), ja sen alla ovat sisennettyinä termit, joihin sana sisältyy. Topografisia (C) ja morfologisia (M) termejä ei ole merkitty saman otsikon alle sekaisin, vaan kummankin ryhmän edellä ja jäljessä on aina tyhjä rivi. 11 Ensimmäinen hakutermi on ”Abdomen”. Koska se esiintyy vähintään kolmen termin osana, se on lihavoitu. ”NOS”-termi on aina merkitty ensimmäiseksi hakutermin alle (ei siis aakkosjärjestykseen N:n kohdalle). ”Abdomen”-ryhmän ja seuraavien kahden, ”Abdominal”-sanan sisältävän termin välissä on tyhjä rivi. Koska sanan ”abdominal” sisältäviä morfologiatermejä on vain kaksi, ne eivät tarvitse otsikkoa. Seuraavilla neljällä topografiatermillä on taas lihavoitu otsikko ”Abdominal”. Aakkosellisessa hakemistossa tyhjä tila merkitsee seuraavaa: 1. topografiatermien vaihtumista morfologiatermeihin tai päinvastoin 2. ryhmän loppua Taulukko 11. Aakkosellisen hakemiston 1. palsta -A- C76.2 C47.4 C49.4 C49.4 C47.4 C44.5 C49.4 Abdomen NOS autonomic nervous system connective tissue muscle peripheral nerve skin subcutaneous tissue M-8822/1 Abdominal desmoid M-8822/1 Abdominal fibromatosis C49.4 C15.2 C77.2 C49.4 Abdominal aorta esophagus lymph node vena cava C76.2 C44.5 C49.4 C49.4 C47.4 C49.4 C49.4 C49.4 C49.4 C47.4 C49.4 C44.5 C49.4 C49.4 Abdominal wall NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C72.5 Abducens nerve Abnormal marrow eosinophils, acute myeloid leukemia with (includes all M-9871/3 variants) Abnormal marrow eosinophils, acute myelomonocytic leukemia with M-9871/3 (includes all variants) M-8075/3 Acantholytic squamous cell carcinoma M--------- Acanthoma, clear cell (see SNOMED) M--------- Acanthosis nigricans (see SNOMED) 12 Kasvaimen kaltaiset muutokset ja tilat Kuten taulukon 11 alaosasta ilmenee, aakkoselliseen hakemistoon on sisällytetty aakkosjärjestyksen mukaisesti myös tiettyjä kasvaimen kaltaisia muutoksia ja tiloja. Ne on mahdollista sekoittaa kasvaimiin: esimerkiksi niiden nimi päättyy kirjaimiin ”oma” tai ne ovat esiasteita. M-tunnuksen jälkeen ei ole annettu ICD-O-morfologiakoodia, vaan pelkästään seitsemän lyhyttä viivaa (M-------), koska näitä tiloja ei pidetä kasvaimina. Sen sijaan termin jälkeen viitataan SNOMED:iin (see SNOMED) eli julkaisuun Systematized Nomenclature of Medicine (2, 3). ICD-O:n aikaisemmissa laitoksissa ilmoitettiin SNOMED-koodi. Koska SNOMED:sta on tällä hetkellä käytössä ainakin kaksi laitosta ja näiden ei-pahanlaatuisten muutosten ja tilojen koodit vaihtelevat, SNOMED-koodit on jätetty pois ICDO-3:sta. Lymfoomien ja leukemioiden alatyyppitermien listaus hakemistossa Lymfoomat ja leukemiat muodostavat poikkeuksen säännöstä, jonka mukaan monisanaiset termit aakkostetaan jokaisen osansa mukaan. Leukemioita ja lymfoomia kuvataan niin monin eri termein ja niiden yhdistelmin, että kaikkien mukaan ottaminen olisi paisuttanut hakemistoa liikaa. Hakemistossa on yksi listaus lymfoomista ja leukemioista kohdissa ”lymphoma, malignant” ja ”leukemia”. NOS (Not Otherwise Specified; tarkemmin määrittämätön) sekä sen käyttö Topografia- ja morfologiatermin jälkeen on kirjoitettu ”NOS”, jos termin yhteydessä on toisaalla ICD-O:ssa käytetty täsmentäviä lisäsanoja tai -fraaseja. Aakkosellisessa hakemistossa NOS esitetään ensin, ja vasta sen jälkeen aakkosjärjestyksessä muut täsmentävät sanat. Koodia, joka tarkoittaa ”termi + NOS”, käytetään seuraavissa tapauksissa: 1. topografia- tai morfologiatermiä ei ole täsmennetty 2. topografia- tai morfologiatermiin sisältyy adjektiivi, jota ei esiinny muualla 3. termiä käytetään yleismerkityksessä Taulukosta 12 ilmenee esimerkiksi, että aakkosellisessa hakemistossa termiä ”adenocarcinoma, NOS” seuraa pitkä luettelo adjektiivimuotoisia täsmennyssanoja, joilla kullakin on oma koodinsa. Jos diagnoosi on adenokarsinooma, oikea koodi on M-8140/3 "adenocarcinoma, NOS". Jos diagnoosissa esiintyy esimerkiksi fraasi ”atypical adenocarcinoma”, koodi on samoin M-8140/3, koska adjektiivia atypical /epätyypillinen ei esiinny adenokarsinoomaa täsmentävien termien luettelossa. Siten NOS on merkitty sekä koodinumeroluetteloon että aakkoselliseen hakemistoon, jotta koodaaja ja koodin tulkitsija tietäisivät, että muut termin täsmennykset löytyvät toisaalta. 13 Muutamassa tapauksessa NOS ilmoittaa myös, että tiettyä termiä käytetään yleismerkityksessä. Esimerkiksi NOS on merkitty sanan ”umpirauhanen” jälkeen kohtaan ”C75.9 umpirauhanen, NOS” ilmoittamaan, että tietyt umpirauhaset, kuten ”käpyrauhanen” ja ”aivolisäke” on merkitty omilla koodeillaan. Taulukko 12. Esimerkki NOS-koodin sijoituksesta M-8140/3 M-8140/6 M-8280/3 M-8550/3 M-8550/3 M-8370/3 M-8251/3 Adenocarcinoma (see also carcinoma) NOS NOS, metastatic acidophil (C75.1) acinar acinic cell adrenal cortical (C74.0) alveolar (C34._) M-8215/3 M-8215/3 M-8244/3 M-8560/3 M-8560/3 M-8401/3 anal ducts (C21.1) anal glands (C21.1) and carcinoid, combined and epidermoid carcinoma, mixed and squamous cell carcinoma, mixed apocrine M-8147/3 M-8300/3 M-8160/3 M-8250/3 M-8250/3 M-8420/3 M-8270/3 basal cell (C07._, C08._) basophil (C75.1) bile duct (C22.1, C24.0) bronchiolar (C34.1) bronchiolo-alveolar, NOS (C34._) ceruminous (C44.2) chromophobe (C75.1) jne. PAHANLAATUISET HEMATOLOGISET SAIRAUDET ICD-O-3:n kaikkien kasvainten luokittelu on uudistettu ja päivitetty, mutta eniten muutoksia on tehty pahanlaatuisten hematologisten sairauksien ryhmässä. Itse asiassa uuden laitoksen laadinnan tärkeimpiä syitä oli tarve antaa koodit uusille hematopatologisille diagnooseille. Viimeksi kuluneiden 50 vuoden aikana on laadittu useita leukemian ja lymfooman luokituksia. Jotkin niistä ovat vaikuttaneet merkittävästi kliiniseen käytäntöön, toiset taas on lähes unohdettu. Enimmäkseen näiden vuosikymmenten aikana on lymfooman ja leukemian välistä eroa pidetty ratkaisevan tärkeänä, ja kummallekin ryhmälle on kehitelty erillisiä luokitteluja. 14 Useimmat lymfooman luokittelujärjestelmät voidaan jakaa kahteen ryhmään. Kasvaimet voidaan jaotella pelkästään morfologisten piirteiden, kuten solun koon ja muodon mukaan, sekä sen mukaan onko kasvaimen lähtökohta imusolmukkeessa tai muussa kudoksessa. Tähän perustuu Rappaportin luokittelu, joka julkaistiin vuonna 1955 ja joka oli merkittävä virstanpylväs lymfoomatutkimuksessa. Normaalien lymfosyyttien toimintaa opittiin merkittävässä määrin ymmärtämään vasta kymmenen vuotta myöhemmin. Sen sijaan Kiel-luokitus sekä Lukesin ja Collinsin luokitus perustuivat ajatukselle, jonka mukaan pahanlaatuisessa lymfoomassa solujen kypsyminen on pysähtynyt ja kasvaimet voidaan luokitella vertaamalla niitä lymfosyyttien erilaistumisen normaalivaiheisiin. Yhdysvalloissa National Cancer Institute loi ”Working Formulation”-välineen, jonka avulla voitiin muuntaa diagnostinen tieto yhtenäiseen muotoon vertailujen helpottamiseksi. Käytännössä Working Formulationista muodostui oma luokittelunsa, joka Rappaportin luokituksen tavoin perustui pääasiassa morfologisiin piirteisiin. Useimmissa lymfooman luokitusjärjestelmissä oli mukana gradeerausasteikko, jolla moninaiset kasvaintyypit voitiin yksinkertaistaa muutamaan luokkaan lähinnä kliinisiin tarkoituksiin. On kuitenkin tärkeää ymmärtää, että eri luokitusjärjestelmien asteikkoja ei varsinaisesti ole mahdollista vertailla keskenään. Kiel-luokituksessa asteikon ylä- ja alapää viittasivat kasvaimen solujen kokoon. Working Formulationin asteikot oli saatu luokituksen perustaksi tehdyssä tutkimuksessa kerätystä ennustetiedosta; kliinisessä käytössä asteikon yläpää alkoi tarkoittaa aggressiivista kasvainta, joka mahdollisesti reagoisi kemoterapiaan, kun asteikon alapäähän luokitellut lymfoomat olivat hitaammin kehittyviä, mutta usein parantumattomia. French-American-British (FAB)-järjestelmä (7) oli vastaavanlainen, mutta itsenäinen, lymfaattisten ja myelooisten leukemioiden ja myelodysplasioiden luokittelu, joka perustui perinteisesti värjättyihin näytteisiin. 1990-luvun alussa alkoi käydä selväksi, että leukemioiden ja lymfoomien luokitusjärjestelmissä oli monia ongelmia. Immunologisten ja molekyylibiologisten tekniikoiden kehittäminen oli osoittanut, että erilliset luokat olivat itse asiassa heterogeenisia. Oli ilmeistä, että lymfooman gradeerauksen käyttäminen kliinisten kokeiden tai epidemiologisten tutkimusten pohjana saattoi olla erittäin harhaanjohtavaa. Kun määritelmät täsmentyivät, kävi yhä selvemmäksi, että lymfaattisten leukemioiden ja lymfoomien erottelu oli suurelta osin keinotekoista; se osoitti, miten tauti levisi yksittäisissä potilaissa, mutta ei niinkään ratkaisevia soluihin liittyviä tai kliinisiä eroja. Lymfoomien luokituksen kulmakiviä oli Hodgkinin taudin ja non-Hodgkinlymfooman erottaminen toisistaan. Tutkimukset osoittivat, että Hodgkinin taudin kasvainsolut ovat peräisin itukeskuksen B-soluista ja että Hodgkinin tautia tulisi sen tähden pitää yhtenä B-solulymfooman muotona, eikä omana kasvainryhmänään. Sytogeneettiset tutkimukset ovat osoittaneet kromosomitranslokaatioiden ja yksittäisten geenimuutosten merkityksen useiden leukemia- ja lymfoomatyyppien patogeneesissä ja kliinisessä käyttäytymisessä, vaikka kasvainten patogeneesin täydellinen ymmärtäminen kestäneekin vielä kauan. Tiedon karttumisen johdosta julkaistiin vuonna 1994 Revised European-American Lymphoma (REAL) -luokitus (6). Vaikka monet siinä käytetyt termit ovat samanlaisia kuin Kiel-luokituksessa, sen taustakäsitteet eivät ole samat. REAL-luokituksessa kliinis-patologisten kokonaisuuksien määritelmät perustuvat morfologiaan, 15 immunofenotyyppiin, geneettisiin muutoksiin ja kliiniseen kuvaan. Vaikka nämä muuttujat voivat esiintyä lukemattomina eri yhdistelminä, tautikokonaisuuksia on itse asiassa suhteellisen vähän, ja yli 90 % lymfaattisista maligniteeteista voidaan luokitella tämän järjestelmän avulla. Hematologisten tautien WHO-luokitus (21, 22) perustuu samalle lähestymistavalle, samoin kuin lymfoproliferatiivisten häiriöidenkin luokittelu. Akuuttien myelooisten leukemioiden (AML) alaluokkiin sovelletuissa periaatteissa on otettu huomioon sytogeneettisten epänormaaliuksien ratkaiseva merkitys sekä eroteltu ”de novo” ja myelodysplasiaan liittyvät AML:t. WHO-luokitusta (taulukko 13) ei voida pitää lopullisena, mutta se tarjoaa hyvän perustan jatkotyölle. Monet pääluokat, esimerkiksi diffuusi suurisoluinen B-solulymfooma, ovat selvästi heterogeenisia kliinisen kuvan ja hoitovasteen suhteen. Tulevaisuudessa ne jaotellaan alaluokkiin solu- ja molekyylibiologisten muuttujien perusteella. Tällä hetkellä ei tosin vielä ole yhteisymmärrystä siitä, miten tämä tulisi tehdä. Todennäköisesti ICD-O:n seuraavan laitoksen hematologisia tauteja käsittelevä osa poikkeaa tästä laitoksesta vähintään yhtä paljon kuin kolmas laitos poikkeaa toisesta. Lymfooma- ja leukemia-osan käyttö Synonyymien käyttö ICD-O:n 2. laitoksessa tapaukset voitiin koodata käyttämällä minkä tahansa senhetkisen luokituksen termejä sekä useita vanhentuneita termejä. Tämän johdosta eri tiedostojen vertailu oli hyvin vaikeaa, erityisesti jos samassa tiedostossa käytettiin monista luokituksista saatuja termejä. Tähän 3. laitokseen on otettu mukaan WHOluokituksen termit, joita ensisijaisesti suositellaan käytettäväksi hematologisissa sairauksissa. Vanhempien järjestelmien termit on pidetty mukana, jotta historiallisten aineistojen yhtenäinen koodaus ja analysointi on mahdollista. WHO-luokituksen termi, jota tarjotaan synonyymiksi vanhalle termille, ei kaikissa tapauksissa ole sen täsmällinen vastine, mutta alan asiantuntijoiden arvion mukaan useimmat tapaukset sisältyvät silti käytettyyn luokkaan. ICD-O:n ja ICD-10:n vastaavuus Jotta ICD-O-3 vastaisi ICD-10:tä, se poikkeaa useassa kohdin hematologisten tautien WHO-luokituksen rakenteesta. Krooniselle lymfosyyttiselle B-soluleukemialle ja pienisoluiselle lymfosyyttiselle B-solulymfoomalle on annettu omat koodit. Niitä pidetään nykyään samana sairautena, ja rekisteritietoja esitettäessä nämä kaksi luokkaa voidaan siis yhdistää. Sama argumentti pätee lymfoblastiseen lymfoomaan ja akuuttiin lymfoblastiseen leukemiaan: niitä pidetään nykyään samana tautina, mutta niille on annettu omat koodit. 16 Immunofenotyyppitiedot Solun merkkiainetutkimukset ovat mullistaneet hematopatologian. Niiden avulla päästään täsmällisiin diagnooseihin. WHO-luokituksessa kasvaimen solulinja liittyy lähes aina diagnoositermiin. Esimerkiksi follikulaarinen lymfooma on määritelmän mukaan B-solutauti. Ainoa tapaus, jossa tämä ei päde, on lymfoblastinen leukemia ja lymfoblastinen lymfooma, joista on mainittava, ovatko ne T- vai B-solutyyppisiä. Asianlaita oli toisin ICD-O:n 2. laitoksessa, jossa monet termit eivät ilmaisseet solulinjaa täsmällisesti. Kolmannessa laitoksessa solulinja näkyy selvästi nelimerkkisestä morfologiakoodista, eikä ylimääräistä 6. merkkiä tarvita. Rekisterit voivat silti halutessaan edelleen koodata lisämerkin avulla tapaukset, joissa diagnoosin tukena on immunofenotyyppiin liittyvää tietoa. Sytogeneettinen tieto Sytogenetiikka ja molekyylibiologiset tutkimukset ovat nykyään ratkaisevan tärkeitä monien hematologisten tautien diagnosoinnissa. Uutuutena ICD-O-3:ssa akuutille myelooiselle leukemialle on määritelty alaluokkia, joilla kuvataan sytogeneettisiä muutoksia. Jos nämä löydökset käyvät ilmi laboratoriolausunnosta, ne ovat luokiteltaessa ensisijaisia muihin tietoihin, esimerkiksi FAB:n morfologiatyyppiin nähden. 17 Taulukko 13. WHO:n hematopoeettisia ja lymfaattisia kasvaimia koskeva luokitus ja ICD-O-koodit HUOM: Vain tärkeimmät tautiluokat on esitetty. ( ) osoittaa kasvaimen vaihtoehtoista kuvausta MYELOID NEOPLASMS ICD-O WHO TERM Myeloproliferative diseases 9875/3 Chronic myelogenous leukemia, Philadelphia chromosome positive {t(9;22)(q34;q11}, {BCR/ABL} 9963/3 Chronic neutrophilic leukemia 9964/3 Chronic eosinophilic leukemia/hypereosinophilic syndrome 9961/3 Chronic idiopathic myelofibrosis 9950/3 Polycythemia vera 9962/3 Essential thrombocythemia 9975/1 Myeloproliferative disease, unclassifiable Myelodysplastic/myeloproliferative diseases 9945/3 Chronic myelomonocytic leukemia 9876/3 Atypical chronic myelogenous leukemia 9946/3 Juvenile myelomonocytic leukemia Myelodysplastic syndromes 9980/3 Refractory anemia 9982/3 With ringed sideroblasts 9980/3 Without ringed sideroblasts 9985/3 Refractory cytopenia (myelodysplastic syndrome) with multilineage dysplasia 9983/3 Refractory anemia (myelodysplastic syndrome) with excess blasts 9986/3 5q– (5q deletion) syndrome 9989/3 Myelodysplastic syndrome, unclassifiable Acute myeloid leukemias (AMLs) AMLs with recurrent cytogenetic translocations 9896/3 AML with {t(8;21)(q22;q22)}, {AML1(CBF-alpha)/ETO} 9866/3 Acute promyelocytic leukemia {AML with t(15;17)(q22;q11-12} and variants, {PML/RAR-alpha} 9871/3 AML with abnormal bone marrow eosinophils {inv(16)(p13q22} or {t(16;16)(p13;q11)}, {CBFb/MYH11} 9897/3 AML with 11q23 abnormalities {MLL} 9895/3 AML with multilineage dysplasia 9895/3 With prior myelodysplastic syndrome 9895/3 Without prior myelodysplastic syndrome 9920/3 AML and myelodysplastic syndromes, therapy-related 9920/3 Alkylating agent-related 9920/3 Epipodophyllotoxin-related (some may be lymphoid) 9920/3 Other types 9861/3 AML not otherwise categorized 9872/3 AML minimally differentiated 9873/3 AML without maturation 9874/3 AML with maturation 9867/3 Acute myelomonocytic leukemia 9891/3 Acute monocytic leukemia 9840/3 Acute erythroid leukemia 9910/3 Acute megakaryocytic leukemia 9870/3 Acute basophilic leukemia 9931/3 Acute panmyelosis with myelofibrosis 9805/3 Acute biphenotypic leukemias 18 Taulukko 13 jatkuu. ICD-O 9728/3 9836/3 9823/3, 9833/3 9671/3 9689/3 9940/3 9732/3, 9699/3 9699/3 9690/3, 9695/3, 9670/3 9731/3 9691/3, 9698/3 9673/3 9680/3 9679/3 9678/3 9687/3, 9826/3 LYMPHOID NEOPLASMS WHO TERM B-CELL NEOPLASMS Precursor B-cell neoplasm Precursor B-lymphoblastic leukemia/lymphoma Precursor B-cell acute lymphoblastic leukemia Mature (peripheral) B-cell neoplasms B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma B-cell prolymphocytic leukemia Lymphoplasmacytic lymphoma Splenic marginal zone B-cell lymphoma (with/without villous lymphocytes) Hairy cell leukemia Plasma cell myeloma/plasmacytoma Extranodal marginal zone B-cell lymphoma of MALT type Nodal marginal zone B-cell lymphoma (with/without monocytoid B cells) Follicular lymphoma Mantle-cell lymphoma Diffuse large B-cell lymphoma Mediastinal large B-cell lymphoma Primary effusion lymphoma Burkitt lymphoma/Burkitt cell leukemia 9834/3 9831/3 9948/3 9827/3 9719/3 9717/3 9716/3 9708/3 9700/3, 9701/3 9714/3 9702/3 9705/3 9714/3 T-CELL AND NK-CELL NEOPLASMS Precursor T-cell neoplasm Precursor T-lymphoblastic lymphoma/leukemia Precursor T-cell acute lymphoblastic leukemia Mature (peripheral) T-cell neoplasms T-cell prolymphocytic leukemia T-cell granular lymphocytic leukemia Aggressive NK-cell leukemia Adult T-cell lymphoma/leukemia (HTLV-1 positive) Extranodal NK/T-cell lymphoma, nasal type Enteropathy-type T-cell lymphoma Hepatosplenic gamma–delta T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Mycosis fungoides/Sezary syndrome Anaplastic large-cell lymphoma, T/null cell, primary cutaneous type Peripheral T-cell lymphoma, not otherwise characterized Angioimmunoblastic T-cell lymphoma Anaplastic large-cell lymphoma, T/null cell, primary systemic type 9659/3 9650/3 9665/3, 9667/3 9651/3 9652/3 9653/3 HODGKIN LYMPHOMA (HODGKIN DISEASE) Nodular lymphocyte-predominant Hodgkin lymphoma Classical Hodgkin lymphoma Nodular sclerosis Hodgkin lymphoma (grades 1 and 2) Lymphocyte-rich classical Hodgkin lymphoma Mixed cellularity Hodgkin lymphoma Lymphocyte depletion Hodgkin lymphoma 9729/3 9837/3 19 Taulukko 13 jatkuu. ICD-O 9741/3 9741/3 9742/3, 9740/3 9755/3 9751/1 9756/3 9757/3 9758/3 9757/3 MAST CELL DISEASES WHO TERM Cutaneous mastocytosis Systemic mast cell disease Mast cell leukemia/sarcoma HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS Macrophage/histiocytic neoplasm Histiocytic sarcoma Dendritic cell neoplasms Langerhans cell histiocytosis Langerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell sarcoma/tumor Dendritic cell sarcoma, not otherwise specified 20 TOPOGRAFIAN JA MORFOLOGIAN KOODAUSOHJEET 21 TIIVISTELMÄ: ICD-O-3 KOODAUKSEN PERUSSÄÄNNÖT Taulukosta 14 ilmenee -sääntöjen suhde ICD-O-2 -sääntöihin. SÄÄNTÖ A. Topografiset alueet ja epätäsmälliset paikat: Jos diagnoosissa ei ole määritelty alkuperäkudosta, koodaa mieluiten ne mahdolliset kudokset, joihin viitataan aakkosellisessa hakemistossa kunkin epätäsmällisen paikan kohdalla; vältä NOS-luokkaa. Epätäsmälliset paikat, esimerkiksi ”käsivarsi”, koostuvat useista kudoksista. Esimerkiksi ”käsivarren levyepiteelikarsinooma” koodataan mieluiten koodilla C44.6 (käsivarren iho), ei C76.4 (käsivarsi, NOS). Katso koodausohjeet, s. 26. Tästä on muutamia poikkeuksia, kuten leuka ja otsa, jotka muodostuvat pääasiassa ihosta, ja siksi NOS-luokaksi on määritelty iho. SÄÄNTÖ B. Etuliitteet: Jos topografiseen paikkaan liittyy etuliite, kuten peri-, para-, tms., jota ei ole ICD-O-3:ssa, koodauksessa käytetään sopivinta epätäsmällistä alaluokkaa C76 (epätäsmällinen paikka), ellei kasvaintyyppi osoita, että alkuperä on jokin tietty kudos. Tämä yleissääntö pätee myös epätäsmällisiin ilmaisuihin kuten ”...:n seutu”, ”...:n alue”. Katso koodausohjeet, s. 27. SÄÄNTÖ C. Kasvaimet, jotka sijaitsevat useammassa kuin yhdessä topografisessa paikassa tai sen alaluokassa: Käytä alaluokkaa ”.8 - eri alueisiin ulottuva leesio”, kun kasvain kuuluu kahteen tai useampaan luokkaan tai alaluokkaan eikä sen alkukohtaa voida määrittää. (Katso koodausohjeet, s. 28, ja huomautus, s. 50.) Koska kasvaimille on ICD-10:ssä annettu useampia luokkia kuin ICD-9:ssä, muutama aikaisempi kolminumeroinen luokka on korvattu kahdella kolmimerkkisellä luokalla. Nämä .8-luokat on lueteltu koodausohjeiden taulukossa 17 sivulla 28. SÄÄNTÖ D. Lymfoomien topografiakoodit: Jos lymfooman lähtöpaikka on imusolmukkeissa, käytä koodia C77._. Jos lymfooma ulottuu usealle imusolmukealueelle, käytä koodia C77.8 (Eri alueiden imusolmukkeet). Koodaa ekstranodaaliset lymfoomat alkuperäpaikan mukaan; tämä voi olla muu kuin biopsian ottopaikka. Jos lymfooman paikkaa ei ole merkitty ja sitä epäillään ekstranodaaliseksi, käytä koodia C80.9 (tuntematon sijaintipaikka). Koska lymfoomia esiintyy sekä selvästi määritellyissä paikoissa, kuten mahalaukussa, että imusolmukkeissa, niille ei ole voitu antaa täsmällistä paikkaa ilmoittavaa topografiakoodia. Selvästi tietyissä elimissä esiintyviä lymfoomia kutsutaan ekstranodaalisiksi. (Katso koodausohjeet, s. 29, ja pahanlaatuisia lymfoomia koskeva osa, s. 14.) SÄÄNTÖ E. Leukemioiden topografiakoodi: Käytä leukemioissa koodia C42.1 (luuydin), lukuun ottamatta myelooisia sarkoomia (M-9930/3). Katso koodausohjeet, s. 29. 22 SÄÄNTÖ F. Morfologiaan liittyvä käyttäytymiskoodi (behavior): Käytä 5. merkkinä sopivinta käyttäytymiskoodia, vaikka näin syntyvää termiä ei sisältyisikään ICD-O-3:een. Viidennen merkin käyttö on selostettu koodausohjeissa sivulla 33 ja taulukossa 20 sivulla 34 (Matriisi). Oikeaa käyttäytymiskoodia tulee käyttää silloinkin, kun näin syntyvä termi ei sisälly ICD-O:hon; esimerkiksi diagnoosille ”hyvänlaatuinen kordooma” annetaan koodi M-9370/0. Jos patologi on todennut, että käyttäytyminen poikkeaa ICD-O:ssa tavallisesti mainitusta käyttäytymisestä, koodataan patologin lausunnon mukaisesti. SÄÄNTÖ G. Erilaistumiskoodi (grade tai differentiation): Käytä korkeinta diagnoosissa kuvattua erilaistumiskoodia. Kasvainten erilaistumista kuvaavan 6. merkin käyttö (taulukko 21, s. 35) on selitetty koodausohjeissa sivulla 34. Jos diagnoosissa mainitaan kaksi eri erilaistumisastetta (kuten ”hyvin ja huonosti erilaistunut” tai ”gradus II–III”), koodataan korkeamman asteen mukaan (tässä tapauksessa III). Kuudennella merkillä voidaan myös ilmoittaa lymfooman tai leukemian solujen alkuperä (taulukko 22, s. 36). Näissä lymfaattisissa ja hematopoeettisissa taudeissa koodataan mieluummin T-solu (koodi 5), B-solu (6), Null-solu (7) ja NK-solu (8) kuin erilaistuminen (koodit 1–4). SÄÄNTÖ H. Morfologiatermit, joihin liittyy tietty paikka: Käytä ICD-O-3:n tarjoamaa topografiakoodia, kun diagnoosissa ei ole mainittu topografista paikkaa. Tätä topografiakoodia ei oteta huomioon, jos kasvaimen alkukohdaksi tiedetään jokin muu paikka. Morfologiatermin jälkeen on annettu suluissa paikkakoodi silloin, kun kasvain tavallisesti esiintyy samassa paikassa tai kudoksessa, kuten esimerkiksi ”retinoblastoma” (C69.2). Jos diagnoosissa ei mainita paikkaa, käytä ehdotettua koodia. Jos diagnoosissa mainittu paikka poikkeaa morfologiselle tyypille ehdotetusta paikkakoodista, käytä mainitun paikan koodia. Varmista, ettei kasvain ole etäpesäke. Joillekin paikoille on annettu vain kolmimerkkiset koodit, esim. C44._ (iho), koska oikeaa neljättä merkkiä ei voida antaa etukäteen. Katso koodausohjeet, s. 36. Muutamien kasvainten nimet viittaavat topografiseen paikkaan (näennäistopografiset morfologiatermit), mutta niiden paikkaa koodattaessa ei ilman muuta pidä käyttää tätä paikkaa. Esimerkiksi ”bile duct carcinoma” on kasvain, jonka lähtökohta voi olla myös maksansisäisissä sappiteissä (C22.1). Katso koodausohjeet, s. 38. SÄÄNTÖ J. Yhdistelmämorfologiat: Jos yhdystermiä ei löydy ICD-O-3:sta, vaihda sanan osien paikkaa. Yhdistelmien kaikkia muotoja ei ole lueteltu. Esimerkiksi sanaa ”myxofibrosarcoma” ei löydy ICD-O-3:sta, mutta muoto ”fibromyxosarcoma” löytyy. Jos ensimmäistä termiä ei löydy, tarkista, löytyykö jokin muu sanoista. Katso koodausohjeet, s. 38. 23 SÄÄNTÖ K. Useiden morfologiatermien koodaus: Mikäli kaikkia diagnoosissa käytettyjä termejä ei voi koodata yhdellä koodilla, käytä numeroltaan suurempaa koodia, jos yhden kasvaimen diagnoosissa on kaksi täsmentävää adjektiivia, joilla on eri koodit. Jos termiin liittyy kaksi tai useampia täsmentäviä adjektiiveja, joilla on eri koodit, käytä sitä, jonka koodinumero on suurin, koska se on yleensä täsmällisin. Katso koodausohjeet, s. 39. Taulukko 14. ICD-O:n 3. laitos, säännöt ja niitä vastaavat numerot ICD-O:n 2. laitoksessa. ICD-O, 3. laitos ICD-O, 2. laitos* Topografiset alueet ja epätäsmälliset paikat A 2 Etuliitteet B 3 Kasvaimet, joihin liittyy useampi kuin yksi topografinen luokka tai alaluokka C 4 Lymfoomien topografiakoodit D 12 Leukemioiden topografiakoodi E 13 Käyttäytymiskoodi F 5 Erilaistumiskoodi G 6 Morfologiatermit, joihin liittyy tietty paikka H 8, 9 Yhdistetyt morfologiadiagnoosit J 10 Useiden morfologiatermien koodaus K 11 AIHE * Huomautuksia: Toisen laitoksen 1. säännössä kuvattiin 10- merkkisen koodin rakenne. Toisen laitoksen 7. säännössä kuvattiin termien ”syöpä” ja ”karsinooma” ero. Toisen laitoksen 14. säännössä käsiteltiin multippelien kasvainten koodaamiseen liittyviä seikkoja. Kolmannessa laitoksessa ei ole sääntöä I, jotta vältettäisiin sen mahdollinen sekaantuminen sääntöön 1 24 TOPOGRAFIAN JA MORFOLOGIAN KOODAUSOHJEET TOPOGRAFIA Johdanto Topografiakoodi ilmoittaa kasvaimen alkuperäpaikan. ICD-O-3:n topografiakoodeja ei ole muutettu tai lisätty. Topografiakoodit C00–C80 perustuvat ICD-10:n II luvun pahanlaatuisia kasvaimia koskevaan osaan, kuten todettiin ICD-O:n ja ICD-10:n eroja käsittelevässä kohdassa sivulla 5. ICD-O-3:ssa kaikki kasvaimet käyttäytymisestään riippumatta koodataan samoilla topografiakoodeilla. Kirjoitusmuodot Kasvaimen sijaintipaikka voidaan kuvata substantiivilla tai siitä johdetulla genetiivimuodolla (suomi) tai adjektiivilla (englanti), esimerkiksi ”glioma of pons” tai ”pontine glioma” (aivosillan gliooma). Yleensä ICD-O-3:n koodinumeroluettelossa ja aakkosellisessa hakemistossa on mainittu substantiivi; esimerkiksi ”pons” on mainittu, mutta ”pontine” ei. Vain muutama yleisesti käytetty genetiivimuoto/(adjektiivi) kuten ” kohdun, kohtu- (uterine)” ja ” maha(lauku)n, maha- (gastric)”, on otettu mukaan koodaajien työn helpottamiseksi. Epäselvissä tapauksissa koodaajan tulee etsiä oikea substantiivi lääketieteen sanakirjasta. Erityiset topografiakoodit Ruokatorven osat Koska ruokatorven osien luokitteluun käytetään yleisesti kahta toisistaan poikkeavaa järjestelmää, on ne molemmat sisällytetty ICD-O3:een ja ICD-10:een (taulukko 15). Termit ruokatorven kaula-, rintakehä- ja vatsaosa liittyvät radiologiaan ja operatiiviseen toimintaan; ylä-, keski- ja alakolmannes taas liittyvät endoskopiaan ja kliiniseen kuvailuun. Taulukko 15. Ruokatorven koodin rakenne C15 RUOKATORVI C15.0 Ruokatorven kaulaosa C15.1 Ruokatorven rintakehäosa C15.2 Ruokatorven vatsaosa C15.3 Ruokatorven yläkolmannes C15.4 Ruokatorven keskikolmannes C15.5 Ruokatorven alakolmannes C15.8 Eri alueisiin ulottuva ruokatorven leesio (Ks. huomautus s. 50) C15.9 Esophagus / Ruokatorvi, NOS 25 Kidustasku ja Meckelin divertikkeli kasvainten sijaintipaikkoina ”Kidustasku (brankiaalikysta)” ja ”Meckelin divertikkeli” ovat synnynnäisiä poikkeavuuksia, joten ICD-10:ssä niistä käytetään koodeja Q18.0 ja Q43.0. Niistä syntyvissä kudoksissa voi kuitenkin esiintyä kasvaimia. ICD-O-3:n topografiaosassa on koodit C10.4 (kidustasku) ja C17.3 (Meckelin divertikkeli). Kummankin termin jälkeen on lisätty sulkuihin sanat ”kasvaimen sijaintipaikkana” sen varmistamiseksi, että niitä käytetään vain osoittamaan kasvaimen alkuperäpaikkaa. ICD-O-3:n topografiakoodeja ei tule käyttää näille synnynnäisille poikkeavuuksille, ellei niissä synny kasvaimia. Topografiset alueet ja epätäsmälliset paikat: SÄÄNTÖ A. Jos diagnoosissa ei ole määritelty alkuperäkudosta, käytä mieluiten niiden kudosten koodia, jotka on mainittu aakkosellisessa hakemistossa kunkin epätäsmällisen paikan kohdalla; vältä NOS-luokkaa. Jos diagnoosissa viitataan johonkin ruumiin alueeseen tai epätäsmälliseen paikkaan, koodaus on ongelmallista. Useimmat epätäsmälliset paikat on ICD-O-3:ssa lueteltu koodin C76 kohdalla, mutta eräät, esimerkiksi ”käsivarsi”, koostuvat useista kudoksista (taulukko 16). Diagnoosissa ei välttämättä ole mainittu kasvaimen lähtökudosta. Esimerkiksi ”käsivarsi” voi tarkoittaa ”käsivarren ihoa”, erilaisia ”käsivarren pehmytkudoksia” tai jopa ”käsivarren luita”. Jos kasvaimen lähtöpaikasta ei tiedetä mitään tarkempaa, käytetään koodia ”käsivarsi, NOS” eli C76.4. Käsivarren kasvainten koodaamisen helpottamiseksi eri kudokset on lueteltu aakkosellisessa hakemistossa termin ”käsivarsi” alla. Taulukko 16. Esimerkki aakkosellisen luettelon topografisista alueista C76.4 C44.6 C49.1 C49.1 C47.1 C40.0 C49.1 C49.1 C49.1 C77.3 C49.1 C47.1 C49.1 C44.6 C49.1 C49.1 C49.1 C49.1 Arm NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue lymph node muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath Aakkosellisessa hakemistossa on sulkeissa lueteltu esimerkkejä tavallisista hyvän- tai pahanlaatuisista kasvaimista, ja niiden lähtöpaikkana tavallisesti esiintyvä kudos on mainittu. Käsivarren karsinoomasta, melanoomasta ja luomesta käytetään koodia C44.6 eli topografiakoodia, joka tarkoittaa ”käsivarren iho”. Sulkeisiin merkityt tiedot on tarkoitettu koodaajan avuksi sekä esimerkiksi osoittamaan, että erityyppiset käsivarren karsinoomat koodataan mieluiten koodilla C44.6 (käsivarren iho), ei C76.4 (käsivarsi, NOS). 26 Samalla tavoin sarkooma ja lipooma koodataan C49.1, joka ilmaisee käsivarren erilaisia pehmytkudoksia. Useimmat sarkoomat, kuten fibrosarkooma, liposarkooma ja angiosarkooma, lähtevät yleensä pehmytkudoksesta. Käsivarren tapaan aakkosellisessa hakemistossa on käsitelty muut ruumiin epätäsmälliset paikat ja alueet, jotka on lueteltu koodinumeron C76 alla. Joitain epätäsmällisiä paikkoja, kuten ”leuka, NOS” ja ”otsa, NOS” ei ole sijoitettu koodille C76, vaan ihon koodille C44. Luun kasvaimet vaativat erityistarkkuutta. Sekä osteosarkooma (osteo- tarkoittaa luuta) että kondrosarkooma (chondro- tarkoittaa rustoa) syntyvät yleensä luussa. ”Käsivarren luu” on luetteloitu koodiin C40.0 ”yläraajan pitkät luut, lapaluu ja niiden nivelet”, ja tämä on oikea koodi, kun osteo- tai kondrosarkooma on lähtöisin jostain käsivarren luusta. Ääreishermot ja sidekudokset Ääreishermot (C47._) ja sidekudokset (C49._) koostuvat useista erilaisista kudoksista (luokitukseen sisältyvät termit käyvät ilmi topografian koodinumeroluettelosta). Kaikki koodinumeroluettelon termit eivät ole mukana aakkosellisessa hakemistossa kaikkien ruumiin alueiden kohdalla. Esimerkiksi ”rasvakudos” on liitetty termiin ”sidekudokset tai muut pehmytkudokset”, mutta sitä ei ole lueteltu kaikkien epätäsmällisten paikkojen kohdalla. Etuliitteet SÄÄNTÖ B. Jos topografiseen paikkaan liittyy etuliite, kuten peri-, para- tms., jota ei ole ICD-O-3:ssa, koodauksessa käytetään sopivinta epätäsmällistä alaluokkaa C76 (epätäsmällinen paikka), ellei kasvaintyyppi osoita, että alkuperä on jokin tietty kudos. Etuliitteitä peri-, para-, pre-, supra-, infra- ym. käytetään usein topografisten paikkojen ja eri elinten yhteydessä. Muutama etuliiteellä täsmennetty topografinen paikka on otettu mukaan ICD-O:hon, ja niille on annettu oma koodinsa. Mukana ovat esimerkiksi ”periadrenaalinen kudos”, ”peripankreaattinen kudos” ja ”retrosekaalinen kudos”, joille on annettu koodi C48.0 eli ”retroperitoneum”. ”Para-aortaalinen imusolmuke” on mainittu koodin (C77.2) yhteydessä. ICD-O-3:ssa, ja sillä on sama koodi kuin termillä ”aortic lymph node / aortan imusolmuke”. ICD-O-3:een ei ole voitu ottaa mukaan kaikkia topografisia paikkoja, joihin voi liittyä jokin etuliite. Käytännössä tällaisten etuliitteiden käyttö osoittaa, että paikka on epätäsmällinen. Koodaajien tulee käyttää C76-koodeja muille epätäsmällisille paikoille, joita ei ole erikseen mainittu ICD-O-3:ssa. Sama sääntö pätee muihin epätäsmällisiin kuvauksiin, kuten ”...:n alueella” tai ”...:n seudussa”. 27 Eri alueisiin ulottuva pahanlaatuinen kasvain SÄÄNTÖ C. Käytä alaluokkaa ”.8”, kun yksittäinen kasvain ylittää kahden tai useamman luokan tai alaluokan rajat eikä sen alkukohtaa voida määrittää. Luokkiin C00–C76 sijoitetaan primaarit pahanlaatuiset kasvaimet sen mukaan, mistä elimestä tai kudoksesta ne ovat lähtöisin. Monet kolmimerkkiset koodit on jaettu edelleen kyseisen elimen nimettyihin osiin tai alaluokkiin. Yksittäinen kasvain, joka ulottuu kahdelle tai useammalle vierekkäiselle paikalle kolmimerkkisen luokan sisällä ja jonka alkukohtaa ei voida määrittää, tulee koodata alaluokkaan .8, ”eri alueisiin ulottuva leesio”, ellei kyseinen yhdistelmä löydy hakemistosta. Kasvaimen esiintymispaikkojen tulee olla vieretysten. Peräkkäisillä luvuilla Taulukko 17. Paikkakoodit kasvaimille, jotka ulottuvat merkityt luokat ovat useammalle kuin yhdelle kolmimerkkisellä koodilla merkitylle paikalle useimmiten anatomisesti vierekkäisiä, joskaan ei C02.8 Eri alueisiin ulottuva kielen leesio aina (esim. virtsarakko, Eri alueisiin ulottuva suurten sylkirauhasten leesio C67). Koodaajan voi olla C08.8 Eri alueisiin ulottuva huulen, suuontelon ja nielun syytä tarkistaa anatomian C14.8 leesio kirjasta, ovatko paikat C21.8 Eri alueisiin ulottuva peräsuolen, peräaukon ja vierekkäin vai eivät. peräaukkokanavan leesio Eri alueisiin ulottuva sappiteiden leesio Esimerkiksi ”ruokatorven C24.8 ja mahalaukun C26.8 Eri alueisiin ulottuva ruuansulatuselinten leesio karsinooma” on saanut C39.8 Eri alueisiin ulottuva hengityselinten ja muiden koodin C16.0 ”mahansuu, rintaontelon elinten leesio C41.8 Eri alueisiin ulottuva luun, nivelen tai nivelruston NOS”, mutta ”kielen leesio kärjen ja alapinnan C49.8 Eri alueisiin ulottuva side- tai pehmytkudoksen karsinooma” koodataan leesio luokkaan C02.8 ”eri C57.8 Eri alueisiin ulottuva naisen sukuelinten leesio alueisiin ulottuva kielen C63.8 Eri alueisiin ulottuva miehen sukuelinten leesio leesio”. Toisaalta ”kielen C68.8 Eri alueisiin ulottuva virtsaelinten leesio kärjen karsinooma, joka C72.8 Eri alueisiin ulottuva aivojen ja keskushermoston ulottuu alapinnalle”, tulee leesio koodata luokkaan C02.1, koska sen alkukohta eli kielen kärki on tunnettu. Toisinaan kasvain voi ulottua kahteen tai useampaan paikkaan, joille on annettu kaksi tai useampi kolmimerkkinen luokka. Taulukossa 17 on lueteltu alaluokat, jotka liittyvät elinjärjestelmissä useampiin paikkoihin. Esimerkiksi ”mahalaukun ja ohutsuolen karsinooma” on koodattava luokkaan C26.8 ”eri alueisiin ulottuva ruuansulatuselinten leesio”. 28 Lymfoomien topografiakoodit SÄÄNTÖ D. Jos lymfooman lähtöpaikka on imusolmukkeissa, käytä koodia C77._. Jos lymfooma ulottuu usealle imusolmukealueelle, käytä koodia C77.8 (Eri alueiden imusolmukkeet). Koodaa ekstranodaaliset lymfoomat alkuperäpaikan mukaan; tämä voi olla muu kuin biopsian ottopaikka. Jos lymfooman paikkaa ei ole merkitty ja sitä epäillään ekstranodaaliseksi, käytä koodia C80.9 (tuntematon sijaintipaikka). Lymfoomia pidetään systeemisinä (yleistyneinä) tauteina toisin kuin kiinteitä kasvaimia, kuten rinta- tai mahasyöpiä. Useimmat lymfoomat syntyvät imusolmukkeissa (topografiakoodi C77._) tai imukudoksessa, esimerkiksi risoissa, pernassa, Waldeyerin nielurenkaassa, ohutsuolen Peyerin levyissä tai kateenkorvassa; kaikkia näitä kutsutaan nodaalisiksi lymfoomiksi. Lymfoomia voi myös syntyä eri elinten lymfaattisista soluista esimerkiksi mahalaukun tai suoliston imukudoksesta. Täsmällisesti määritellyissä paikoissa esiintyviä lymfoomia kutsutaan ekstranodaalisiksi tai ekstralymfaattisiksi. Siksi lymfoomille ei ole annettu tiettyyn paikkaan viittaavaa omaa topografiakoodia. Termejä ekstranodaalinen tai ekstralymfaattinen käytetään joskus ristiin. Täsmällisesti sanottuna ekstranodaalinen tarkoittaa, että lymfooma ei ole syntynyt imusolmukkeessa, vaan esimerkiksi jossain edellä mainitussa imukudoksessa. Ekstralymfaattinen taas tarkoittaa, että lymfooma syntyy ei-lymfaattisessa elimessä tai kudoksessa. Nodaalisia tai ekstranodaalisia lymfoomia koodattaessa on tärkeää tunnistaa kasvaimen alkuperäpaikka, joka voi olla muu kuin biopsian ottopaikka ja joka ei ole sama kuin paikallisesti levinnyt kasvain naapurikudoksessa tai etäpesäkkeen paikka. Esimerkiksi diffuusi suurisoluinen B-solulymfooma voi olla joko nodaalinen tai ekstranodaalinen kasvain. Biopsia on voitu ottaa imusolmukkeesta, mutta primaaritaudin merkittävin esiintymä voi olla ekstranodaalisessa elimessä. Kuvantamalla saatu leviämisastetta koskeva tieto on ainoa luotettava menetelmä tämän eron selvittämiseksi, mutta syöpärekisterit eivät aina saa tätä tietoa vaivatta. Jos on selvää, että primaari paikka on ollut tietty imusolmuke, tämä tulee koodata; jos näin ei ole, asianmukainen koodi on C77.9 (imusolmuke, NOS). Jos primaaripaikka ei ilmeisesti ole imusolmuke, asianmukainen koodi on C80.9 (tuntematon sijaintipaikka). On tärkeää ottaa tämä ero huomioon, koska ekstranodaalisten lymfoomien ennuste voi olla parempi. (Lymfoomia on käsitelty tarkemmin sivulla 14.) Leukemioiden topografiakoodi SÄÄNTÖ E. Käytä leukemioissa koodia C42.1 (luuydin), lukuun ottamatta myelooisia sarkoomia (M-9930/3) Myelooinen sarkooma johtuu leukemian leviämisestä elimeen tai kudokseen, ja se tulee koodata alkuperäpaikan mukaan. 29 MORFOLOGIA Morfologiakoodilla osoitetaan neoplastiseksi muuttuneen solun tyyppi ja sen biologinen aktiviteetti eli millainen kasvain on ja miten se käyttäytyy. Täydellisessä morfologiakoodissa on kolme osaa: 4 merkkiä 1 merkki 1 merkki solutyyppi (histologia) käyttäytyminen erilaistuminen tai fenotyyppi ICD-O:n morfologiakoodeissa tietyn kasvaimen solutyyppi koodataan yhteisellä juurella ja sen käyttäytyminen yhdellä lisämerkillä. Erilaistumis- tai fenotyyppikoodilla tallennetaan lisätietoa kasvaimesta. Syöpä ja karsinooma Sanoja ”syöpä/cancer” ja ”karsinooma/carcinoma” käytetään usein (virheellisesti) toistensa asemesta; esimerkiksi sanaa ”levyepiteelisyöpä” käytetään ”levyepiteelikarsinooman” sijasta. Ensin mainitun koodaaminen jälkimmäisen koodilla voisi käydä päinsä. Sen sijaan ”sukkulasolusyöpä /spindle cell cancer” voi viitata joko ”sukkulasolusarkoomaan /spindle cell sarcoma” tai ”sukkulasolukarsinoomaan /spindle cell carcinoma”. ICD-O-3:ssa sana ”syöpä /cancer” on luettelossa vain kerran, ei-spesifin termin ”pahanlaatuinen kasvain /neoplasm, malignant” (M-8000/3) synonyymina. ICD-O-3:ssa ei luonnollisesti ole voitu antaa omia koodeja kaikille tapauksille, joissa sanaa ”syöpä/cancer” käytetään epätäsmällisesti histologisessa diagnoosissa. KÄYTTÄYTYMINEN Kasvaimen käyttäytyminen (behavior) tarkoittaa sitä, miten aktiivinen se on elimistössä eli pahanlaatuisuuden astetta. Patologit havainnoivat kasvaimia monin tavoin määritelläkseen niiden käyttäytymisen. Taulukossa 18 on esitetty eri käyttäytymiskoodit. Kasvain voi kasvaa leviämättä yhdessä paikassa (/0, hyvänlaatuinen); se voi olla pahanlaatuinen, mutta silti vielä paikallisesti kasvava (/2, noninvasiivinen tai in situ); se voi kasvaa ympäröiviin kudoksiin (/3, pahanlaatuinen, alkuperäpaikassaan); tai levitä alkuperäisestä paikastaan muualle (/6, metastaattinen). Useimmat syöpärekisterit keräävät tietoa vain pahanlaatuisista ja in situ -kasvaimista eli sellaisista, joiden käyttäytymiskoodi on /3 tai /2. Käyttäytymiskoodeja /6 (pahanlaatuinen, metastaattinen paikka) ja /9 (pahanlaatuinen, paikan primaarisuus tai metastaattisuus epävarma) ei käytetä syöpärekistereissä. Jos henkilöllä esimerkiksi on karsinooma, joka on levinnyt keuhkoihin ja jonka alkuperäpaikka on tuntematon, oikea koodi on C80.9 (tuntematon sijaintipaikka) M-8010/3 (karsinooma, NOS, pahanlaatuinen). 30 Taulukko 18. Kasvainten käyttäytymiskoodi (5. merkki) Koodi /0 Hyvänlaatuinen /1 Hyvän-/pahanlaatuisuus epävarma Mahdollisesti pahanlaatuinen Vähäinen pahanlaatuisuuspotentiaali Epävarma pahanlaatuisuuspotentiaali Borderline-kasvain Low malignant potential /2 In situ -karsinooma Intraepiteliaalinen Noninfiltroiva Noninvasiivinen /3 /6* Pahanlaatuinen, primaaripaikka Pahanlaatuinen, etäpesäke Pahanlaatuinen, sekundaarinen paikka /9* Pahanlaatuinen, primaarius/metastaattisuus epävarma * Ei käytössä syöpärekistereissä. Karsinooma in situ ja CIN III Useimmat syöpärekisterit tallentavat tiedon in situ -karsinoomista riippumatta niiden alkuperäpaikasta. Ylivoimaisesti suurin määrä in situ -karsinoomia diagnosoidaan kohdunkaulassa. Viime vuosina sytologit ja patologit ovat käyttäneet useita muita lähisukuisia termejä, joista tärkein on intraepiteliaalinen neoplasia. Kohdunkaulan yhteydessä käytetään usein termiä ”cervical intraepithelial neoplasia, grade III” (CIN III). Ikävä kyllä tämä termi sisältää sekä in situ -karsinooman että vaikean dysplasian. Asiasta on keskusteltu useiden maiden johtavien asiantuntijoiden kanssa, ja useimmat ovat katsoneet, että CIN III:a voidaan verrata in situ -karsinoomaan riippumatta siitä, mainitaanko vaikea dysplasia vai ei. Kohdunkaulan vaikea dysplasia, jonka yhteydessä ei ole mainintaa CIN III, koodataan samoin kuin kaikki muut vaikean dysplasian sijaintipaikat SNOMED:n mukaan. Samalla tavoin menetellään, kun kyseessä on vagina (VAIN III), vulva (VIN III) tai anus (AIN III). Jos patologi katsoo, että CIN III (määrittelemätön) ei vastaa in situ -karsinoomaa, hän voi soveltaa tässä julkaisussa esitettyä matriisia ja muuttaa käyttäytymiskoodiksi /1 (hyvän-/pahanlaatuisuus epävarma). 31 Sytologisessa Bethesda-järjestelmässä (23) mainitaan vain kaksi ryhmää, low grade squamous intraepithelial lesion (low SIL) ja high grade squamous intraepithelial lesion (high SIL). High SIL sisältää sekä keskivaikean dysplasian (CIN II) että vaikean dysplasian ja in situ -karsinooman yhdistelmän (CIN III). Käyttäytymiskoodin käyttö patologian laboratorioissa Käsikirjan ohjeet on pääasiassa tarkoitettu koodaajien ja syöpärekisterien käyttöön. Tässä kuitenkin käsitellään patologien luokittelutarpeita. Tärkein näiden kahden ryhmän välinen ero liittyy käyttäytymiskoodin käyttöön. Patologit koodaavat yleensä näytteitä, kun taas syöpärekistereissä tärkein kiinnostuksen kohde on primaarikasvaimen kuvaus. Patologille voi tulla useita saman potilaan näytteitä, esimerkiksi (a) biopsianäyte, (b) resekoitu primaarikasvain ja (c) näyte metastaasista (kts. taulukko 19). Patologi haluaa erotella nämä kolme näytettä, mutta syöpärekisteriä kiinnostaa vain näyte alkuperäpaikan kasvaimesta. Kukin näyte koodataan oman topografiansa ja morfologiansa mukaan, mutta taulukon 19 esimerkkitapauksessa (b)-näytteen käyttäytymiskoodiksi merkitään /3, kun taas (a):n ja (c):n käyttäytymiskoodi on /6 (metastaattinen), mikä ilmaisee, että näytteen topografiakoodi ei osoita kasvaimen alkuperäpaikkaa. Syöpärekisteriin taas merkitään vain (b) – alkuperäinen paikka ja morfologia sekä käyttäytymiskoodi /3. Taulukko 19. Esimerkkejä näytteiden koodaamisesta laboratoriossa a. Biopsiadiagnoosi: Solisluun yläpuolinen imusolmuke, metastaattinen sinettisormussoluadenokarsinooma, todennäköisesti mahalaukusta. C77.0 8490/6 *b. Primaaripaikka: Mahanpohjukka, sinettisormussoluadenokarsinooma C16.1 8490/3 c. Etäpesäke: Keuhkoputken ylälohko, metastaattinen sinettisormussoluadenokarsinooma C34.1 8490/6 * Nämä koodit kirjataan rekisteriin. 32 MORFOLOGIAKOODIN MATRIISI SÄÄNTÖ F. Käytä 5. merkkinä sopivinta käyttäytymiskoodia, vaikka termi ei sisältyisikään ICD-O-3:een. Taulukossa 20 on esitetty ICD-O-3:n morfologiakoodien perusperiaate ja rakenne. Ensimmäisessä esimerkissä (A) on viisi termiä ja niiden morfologiakoodit. Kullakin viidellä termillä on sama nelimerkkinen morfologiakoodi, M-8140, joka tarkoittaa rauhaskudoksen kasvainta. ”Adenooma, NOS” on hyvänlaatuinen kasvain, ja sen käyttäytymiskoodi on /0. ”Adenokarsinooma, NOS” on termin ”adenooma, NOS” pahanlaatuinen vastine, ja sen käyttäytymiskoodi on /3. Termin ”Adenokarsinooma in situ” käyttäytymiskoodi on /2. ”Bronkiaalinen adenooma” on alun perin kuvattu hyvänlaatuiseksi kasvaimeksi, mutta myöhemmin sen on todettu olevan pahanlaatuinen tai mahdollisesti pahanlaatuinen. Tämän vuoksi ”bronkiaalinen adenooma, NOS” on saanut käyttäytymiskoodin /1, joka tarkoittaa, ettei ole varmaa, osoittautuuko tietty bronkiaalinen adenooma hyvän- vai pahanlaatuiseksi. ”Metastaattinen adenokarsinooma, NOS” on saanut koodin M-8140/6. Matriisiin sisältyy myös koodi M-8140/9, vaikka sitä ei esiinny ICD-O:n koodinumeroluettelossa tai aakkosellisessa hakemistossa. Jos kliinisissä tai patologisissa tiedoissa näkyy diagnoosi ”keuhkojen adenokarsinooma, paikka joko primaari tai metastaattinen”, sen koodiksi voidaan antaa M8140/9. Tätä koodia ei käytettäisi syöpärekistereissä. Toisessa esimerkissä (B) nelimerkkisen morfologiakoodin M-9000 alla on annettu kolme termiä. ”Brennerin tuumori, NOS” on tavallisesti hyvänlaatuinen, joten sen koodi on M-9000/0. Jos lausunnossa kuitenkin lukisi ”pahanlaatuinen Brennerin tuumori”, sen oikea koodi olisi M-9000/3; vastaavasti diagnoosin ”Brennerin tuumori, mahdollisesti pahanlaatuinen” oikea koodi olisi M-9000/1. Koodeja M-9000/2, M9000/6 ja M-9000/9 ei ole ICD-O-3:ssa. Niitä on mahdollista käyttää tarvittaessa; esimerkiksi M-9000/2 tarkoittaisi ”Brennerin tuumori in situ”, sikäli kuin tällainen joskus löytyisi. Kolmannessa esimerkissä (C) on vain yksi termi, ”kordooma”. ”Kordooma” katsotaan yleensä pahanlaatuiseksi kasvaimeksi, joten sen morfologiakoodi on M-9370/3. Taulukossa 20, 9370-matriisissa on myös muita koodeja, ja niitä voidaan tarvittaessa käyttää; esimerkiksi M-9370/0 tarkoittaisi ”hyvänlaatuista kordoomaa”, joskaan tällaista ei ole mainittu ICD-O-3:ssa. Huomattakoon, että eräitä mahdollisia yhdistelmiä ei todennäköisesti koskaan esiinny tai niitä ei ole havaittu ja määritelty; esimerkiksi ”hyvänlaatuinen sarkooma” olisi ristiriidassa nykyisten käsitysten ja käytäntöjen kanssa. Yleensä histologiseen termiin liittyy selvä indikaatio kasvaimen todennäköisestä käyttäytymisestä, olipa se hyvän- tai pahanlaatuinen, ja tämä käy ilmi myös siitä käyttäytymiskoodista, joka sille on annettu ICD-O-3:n morfologialuettelossa. ICD-O3:ssa on mainittu vain muutama histologinen in situ -kasvaintyyppi. Käyttäytymiskoodi /2 voidaan liittää mihin tahansa ICD-O-3:n nelimerkkiseen koodiin, mikäli kasvain on diagnosoitu in situ -tyyppiseksi. Korostettakoon, että matriisijärjestelmän avulla patologi päättää, katsotaanko kasvain käyttäytymiseltään hyvänlaatuiseksi, pahanlaatuiseksi, in situ -tyyppiseksi tai mahdollisesti pahanlaatuiseksi. 33 TAULUKKO 20. MORFOLOGIA- JA KÄYTTÄYTYMISKOODIMATRIISI Esimerkki A Esimerkki B Esimerkki C 8140 9000 9370 Perussolutyyppi 5. merkki: käyttäytymiskoodi /0 Hyvänlaatuinen /1 Hyvän/pahanlaatuisuus epävarma 8140/0 Adenooma, NOS 8140/1 Bronkiaalinen adenooma (C34._) /2 In situ, noninvasiivinen 8140/2 In situ 9000/2 -adenokarsinooma 9370/2 /3 Pahanlaatuinen, primaari 8140/3 Adenokarsinooma, NOS 9370/3 Kordooma /6 Pahanlaatuinen, etäpesäke* 8140/6 9000/6 Adenokarsinooma, etäpesäke 8140/9 /9 Pahanlaatuinen, primaarius/metastaattisuus epävarma* 9000/0 Brennerin tuumori, NOS (C56.9) 9000/1 Brennerin tuumori, mahdollisesti pahanlaatuinen (C56.9) 9000/3 Pahanlaatuinen Brennerin tuumori (C56.9) 9000/9 9370/0 9370/1 9370/6 9370/9 * Ei käytössä syöpärekistereissä. Esitetyt käyttäytymiskoodit perustuvat patologien tulkintaan siitä, miten kasvaimet tavallisimmin käyttäytyvät. Jos patologi on eri mieltä ICD-O-3:n tarjoamasta koodista, hän voi käyttää toista käyttäytymiskoodia. Esimerkiksi Pagetin tauti on ICD-O-3:ssa määritelty pahanlaatuiseksi. Äskettäin eräät patologit ovat esittäneet, että oikeampi luokitus olisi ”in situ”, koska selvää kasvainta ei ole. Tätä mieltä olevien on mahdollista luokitella kasvain näin ja antaa sille vastaava käyttäytymiskoodi. On muistettava, että ICD-O-3 on topografian ja morfologian koodausjärjestelmä (toisin sanoen koodinumeroitu nimistö), eikä sillä ole tarkoitus koodata taudin levinneisyyttä. ICD-O-3:lla ei ole mitään yhteyttä International Union Against Cancer (UICC) -järjestön tai American Joint Committee on Cancer (AJCC) -järjestön TNM-luokituksiin. Koodaus perustuu patologin lausuntoon. Jos kasvaimen käyttäytyminen on epäselvä tai sitä ei ole mainittu, käytetään ICD-O-3:n tarjoamaa käyttäytymiskoodia. Histologisen erilaistumisen (grade ja differentiation) koodaaminen (6. merkki) SÄÄNTÖ G. Käytä suurinta diagnoosissa kuvattua erilaistumista vastaavaa numerokoodia. ICD-O-3:ssa on morfologiakoodin kuudentena merkkinä yhden merkin koodi, joka osoittaa pahanlaatuisten kasvainten erilaistumista (taulukko 21). Vain pahanlaatuisille kasvaimille annetaan erilaistumista kuvaava koodi. Erilaistumisen määrittelytavat vaihtelevat suuresti, ja kaikkien pahanlaatuisten kasvainten erilaistumista ei arvioida rutiininomaisesti. Taulukosta 21 ilmenee, että koodinumeroilla 1–4 merkitään graduksia I–IV. Lisäksi taulukossa on kunkin erilaistumisasteen sanallinen kuvaus. Erilaistuminen kuvaa sitä, miten paljon tai vähän 34 kasvain muistuttaa sitä normaalia kudosta, jossa se on syntynyt. Patologit käyttävät tätä kuvatessaan hyvin vaihtelevaa sanastoa. Yleensä käytetään sanoja ”hyvin”, ”kohtalaisesti” ja ”huonosti” kuvaamaan erilaistumisastetta, ja nämä vastaavat suunnilleen asteita I, II ja III. Astetta IV vastaavat yleensä sanat ”erilaistumaton” ja ”anaplastinen”. Siten diagnoosit ”levyepiteelikarsinooma, gradus II” ja ”kohtalaisesti erilaistunut levyepiteelikarsinooma” luokiteltaisiin molemmat morfologiakoodilla M8070/32. Jos diagnoosista ilmenee kaksi eri erilaistumisastetta, koodina tulee käyttää suurempaa numeroa. Siten ”kohtalaisen erilaistunut levyepiteelikarsinooma, jossa huonosti erilaistuneita alueita” tulee koodata M-8070/33. Taulukko 21 Koodi 1 I aste 2 II aste 3 4 III aste IV aste 9 Histologisen erilaistumisen koodaaminen (6. merkki) Hyvin erilaistunut Erilaistunut, NOS Kohtalaisen erilaistunut Kohtalaisen hyvin erilaistunut Keskinkertaisen erilaistunut Huonosti erilaistunut Erilaistumaton Anaplastinen Erilaistumisastetta ei ole määritelty tai mainittu tai sitä ei käytetä Erilaistumiskoodi voidaan liittää kaikkiin pahanlaatuisiin kasvaimiin, jos diagnoosissa on tietoa erilaistumisesta. Esimerkiksi diagnoosi ”anaplastinen levyepiteelikarsiooma” koodataan kokonaisuudessaan morfologiakoodilla M-8070/34. Olisi virhe käyttää morfologiakoodia M-8070/39, koska tästä ei käy ilmi erilaistumisaste. Huomattakoon, että sanat ”anaplastinen”, ”hyvin erilaistunut” ja ”erilaistumaton” liittyvät osana histologista diagnoosia noin 15 histologiseen termiin (niiden lisäksi, joilla kuvataan lymfoomia). Esimerkkeinä mainittakoon: "pahanlaatuinen teratooma, anaplastinen" (M-9082/34), "retinoblastooma, erilaistunut" (M-9511/31) ja "follikulaarinen adenokarsinooma, hyvin erilaistunut" (M-8331/31). Koodaajien tulee tällöin käyttää oikean morfologiakoodin lisäksi oikeaa erilaistumiskoodia siten kuin esimerkeistä käy ilmi. Samalla 6. merkillä on myös mahdollista osoittaa leukemioiden ja lymfoomien solulinja (taulukko 22). Tästä voi olla hyötyä, kun verrataan ICD-O-3:n mukaan koodattuja tietoja 2. laitoksen perusteella koodattuun tietoon. Kuten sivulla 14 lymfoomia koskevassa osassa on todettu, ICD-O-3:ssa solulinja näkyy selvästi nelimerkkisestä morfologiakoodista, eikä ylimääräistä 6. merkkiä tarvita. Rekisterit voivat silti halutessaan edelleen merkitä lisämerkillä tapaukset, joissa diagnoosin tukena on olemassa immunofenotyyppiin liittyvää tietoa. Tällöin immunofenotyypin koodi korvaa muut erilaistumisastetta kuvaavat diagnoositermit (esim. ”hyvin erilaistunut” tai ”III aste”). 35 Taulukko 22. Lymfoomien ja leukemioiden immunofenotyypin ilmaiseminen (6. merkki) Koodi 5 T-solu 6 B-solu Pre-B B-esiaste 7 NULL-solu Non T-non B 8 NK-solu Luonnollinen tappajasolu 9 Solutyyppiä ei ole määritelty tai mainittu Morfologiatermit, joihin liittyy tietty paikka: SÄÄNTÖ H. Käytä annettua topografiakoodia, kun diagnoosissa ei ole mainittu topografista paikkaa. Tätä topografiakoodia ei oteta huomioon, jos kasvaimen lähtökohdaksi tiedetään jokin muu paikka. Jotkin kasvaimista käytettävät termit osoittavat, että kasvain on syntynyt tietyillä paikoilla tai tietyissä kudoksissa. Tästä on esimerkkejä taulukossa 23. Tällaisten termien koodauksen helpottamiseksi on sopivissa kohdin sulkuihin lisätty topografiakoodi sekä morfologian koodinumeroluetteloon että aakkoselliseen hakemistoon. Toisinaan topografiakoodi on mukana kolmimerkkisessä otsikossa, ja tällöin se koskee kaikkia otsikon alla olevia termejä. Esimerkiksi ”tyvisolukarsinoomalle/basal cell carcinoma” (taulukko 23) on annettu ihon topografiakoodi (C44._), ja neljäs merkki on jätetty avoimeksi. Pisteen jälkeinen alaviiva (_) osoittaa, että tarvitaan tarkempi paikkakoodi. Viivan kohdalle lisätään ilmoitetun mukainen paikkakoodi. Tarkemmat paikkakoodit löytyvät koodinumeroluettelosta tai aakkosellisesta hakemistosta. Esimerkiksi kasvojen tyvisolukarsinooman paikkakoodi on C44.3 (kasvojen iho), mutta käsivarren karsinoomalle annetaan koodi C44.6 (käsivarren iho). Samalla tavoin ”meningiooman” yhteydessä annettu topografiakoodi (C70._) on jätetty avoimeksi, koska paikka voi olla joko ”aivokalvot” (C70.0), ”selkäydinkalvot” (C70.1) tai ”keskushermostokalvot, NOS” (C70.9). Morfologiatermiin liitettyä topografiakoodia voidaan käyttää, kun diagnoosissa ei ole mainittu topografista paikkaa. Moniin morfologiatermeihin ei ole liitetty topografiakoodia, koska kasvain esiintyy usein monissa eri elimissä tai paikoissa. Esimerkiksi termiin ”adenokarsinooma, NOS” ei liity topografiakoodia, koska kasvaimen lähtökohta voi olla monissa eri elimissä. Diagnoosissa mainittu paikka voi poiketa siitä, mikä on osoitettu jonkin morfologiakoodin yhteydessä. Esimerkiksi tyvisolukarsinooma voi esiintyä muualla 36 kuin ihossa. Jos tiedoissa on ilmoitettu muu primaaripaikka, koodaajan tulee ICDO-3:ssa mainitun topografiakoodin sijasta käyttää koodia, joka perustuu diagnoosin tietoihin. Esimerkiksi morfologiatermiin ”infiltrating duct carcinoma / infiltroiva tiehytkarsinooma” on lisätty topografiakoodi C50._ (rinta), koska termiä käytetään yleensä rinnassa esiintyvästä karsinoomasta. Jos termiä ”infiltrating duct carcinoma” kuitenkin käytetään haimassa esiintyvästä primaarista karsinoomasta, tulee ehdotettu rintaan viittaava topografiakoodi korvata oikealla koodilla C25.9 (haima, NOS). Taulukko 23. Esimerkkejä morfologiatermeistä, joihin liittyy paikkakoodi ICD-O:n topografia Morfologia M-9510/3 M-8170/3 Termi Retinoblastooma Hepatosellulaarinen karsinooma (tavallinen primaaripaikka) Muut primaaripaikat C69.2 Verkkokalvo C22.0 Maksa M-8090/3 Tyvisolukarsinooma C44. _ Iho C51._ Vulva C60._ Siitin C63.2 Kivespussi C61.9 Eturauhanen M-9530/0 Meningeooma M-938-M-948 Glioomat M-8500/3 Inflitroiva tiehytkarsinooma, NOS C70._ Keskushermostokalvot C71._ C50._ Aivot Rinta C72.0 Selkäydin C07.9 Korvasylkirauhanen C08._ Sylkirauhanen C25._ Haima C61.9 Eturauhanen M-8470/3 Musinoottinen kystadenokarsinooma C56.9 Munasarja C25._ Haima C34._ Keuhko On muistettava, että morfologiatermeihin lisätyt topografiakoodit osoittavat tiettyjen kasvainten tavallisimpia alkuperäpaikkoja. Epätavallinen, mutta mahdollinen esimerkki on diagnoosi ”munuaisen osteosarkooma”, jolloin tulee käyttää munuaisen topografiakoodia (C64.9) koodin C41.9 (luu, NOS) sijasta, joskin tiedot on ensin tarkistettava sen varmistamiseksi, ettei kyseessä ole luusyövän etäpesäke munuaisessa. Jos munuaisessa on luusyövän (osteosarkooman) etäpesäke, koodi on C41.9 (luu, NOS), M9180/3 (osteosarcoma, NOS). 37 Näennäistopografiset morfologiatermit Eräät kasvainten nimet näyttävät liittyvän tiettyyn alkuperäpaikkaan, mutta kaikkia näitä kasvaimia ei silti pidä luokitella kyseisen topografiakoodin mukaan. Esimerkiksi ”sappitien karsinooma/bile duct carcinoma” (M-8160/3) on tietty histologinen tyyppi, joka voidaan todeta sekä maksansisäisissä (C22.1) että maksanulkoisissa sappiteissä (C24.0), joten sen topografiakoodi ei automaattisesti ole C24.0. Pienten sylkirauhasten kasvaimia voi löytyä mistä tahansa suuontelosta ja sen viereisistä elimistä, ja niitä on useita histologisia tyyppejä, esimerkiksi ”adenoidinen kystinen karsinooma”, ”pahanlaatuinen sekamuotoinen kasvain” ja ”adenokarsinooma, NOS”. Siten ”pienten sylkirauhasten karsinoomalle” ei ole annettu erottavaa morfologiakoodia. Koska kaikkien suun tai suuontelon adenokarsinoomien alkuperäpaikaksi katsotaan pienet sylkirauhaset, sanat ”pienet sylkirauhaset” tulee ohittaa esimerkiksi diagnoosissa ”pienten sylkirauhasten adenoidinen kystinen karsinooma kovassa suulaessa”. Tässä esimerkissä ”adenoidinen kystinen karsinooma” (M-8200/3) tulee koodata topografiseen paikkaan ”kova suulaki” (C05.0). Jos diagnoosissa ei mainita mitään alkuperäpaikkaa ja se on esimerkiksi ”pienten sylkirauhasten adenokarsinooma”, tulee käyttää suuontelon topografiakoodia C06.9, johon sisältyy termi ”pienet sylkirauhaset, NOS”. Morfologiset yhdistelmädiagnoosit: SÄÄNTÖ J. Jos yhdystermiä ei löydy ICD-O-3:sta, vaihda sen osien paikkaa. Eräillä kasvaimilla on monihistologisia sekamuotoja. Tavallisimmat esimerkit on luetteloitu ICD-O-3:ssa, esimerkiksi ”sekamuotoinen adenokarsinooma ja levyepiteelikarsinooma/mixed adenocarcinoma and squamous cell carcinoma” (M-8560/3), ”papillaarinen ja follikulaarinen adenokarsinooma” (M8340/3) ja ”sekamuotoinen tyvisolu-okasolukarsinooma” (M8094/3). Yhdystermi ”fibromyxosarcoma” on ICD-O-3:ssa koodilla M-8811/3, mutta ”myxofibrosarcoma” ei ole. ”Myxofibrosarcoma” on sama kuin ”fibromyxosarcoma”, vaikka sanan osat ovat eri järjestyksessä, ja siksi sen koodi on myös M-8811/3. Tämänkaltaisten yhdystermien kaikkia muotoja ei ole voitu sisällyttää luetteloon. Jos ensimmäistä termiä ei löydy, on tarkistettava, löytyykö jokin muu sen osien yhdistelmä. 38 Useita morfologisia termejä sisältävän diagnoosin koodaus SÄÄNTÖ K. Mikäli kaikkia diagnoosissa käytettyjä morfologiatermejä ei voi koodata yhdellä ainoalla koodilla, käytä numeroltaan suurempaa koodia, jos yhden kasvaimen diagnoosissa on kaksi erilaista adjektiivia, joilla on eri koodit. Kun yhtä kasvainta on kuvattu kahdella täsmentävällä adjektiivilla, joilla on eri koodit, koodaus on ongelmallista. Esimerkiksi ”transitiosellulaarinen epidermoidikarsinooma” on diagnoosi, jossa ei kuvata kahta eri tyyppistä karsinoomaa, vaan yhtä kasvainta, jossa esiintyy molempia solutyyppejä. Termin ”transitiosellulaarinen karsinooma, NOS” koodi on M-8120/3, ja termin ”epidermoidikarsinooma, NOS” koodi on M-8070/3. Kun diagnoosin kaikkia elementtejä ei voi sovittaa yhteen koodiin, on käytettävä numeroltaan suurempaa koodia, sillä yleensä se on täsmällisempi. Tässä esimerkissä koodataan siis M-8120/3. MULTIPPELIT PRIMAARIKASVAIMET Multippeleihin kasvaimiin voi liittyä esimerkiksi seuraavia koodausongelmia: 1. Kaksi tai useampia erillisiä kasvaimia eri topografisissa paikoissa. 2. Syndroomat, joihin liittyy useita kasvaimia. 3. Lymfoomat, joiden diagnoosissa mainitaan useita imusolmukkeita tai elimiä. 4. Kaksi tai useampia morfologialtaan erilaista kasvainta samassa paikassa. 5. Yksi kasvain esiintyy useissa paikoissa, mutta täsmällistä alkuperää ei voida määrittää. Eri rekistereissä määritellään multippelit kasvaimet eri tavoin, eikä tässä ole mahdollista esittää täsmällistä ratkaisua kaikkiin ongelmiin. IARC:n työryhmä on ehdottanut multippelien kasvainten määritelmää, jotta kasvainten ilmaantuvuus voitaisiin raportoida kansainvälisesti vertailukelpoisesti. Työryhmän suositukset ovat seuraavat: 1. Kahden tai useamman primaarin syövän olemassaolon toteaminen ei riipu ajasta. 2. Primaariksi syöväksi katsotaan sellainen, joka saa alkunsa tietyssä paikassa tai kudoksessa, mutta kyseessä ei ole viereiseen kudokseen levinnyt kasvain, syövän uusiutuma eikä etäpesäke. 3. Vain yhden kasvaimen katsotaan syntyvän yhdessä elimessä, elinparissa tai kudoksessa. Jos kasvaimen paikka on koodattu ICD-O:n 1. laitoksen (tai ICD9:n) mukaan, elin tai kudos määritellään topografiakoodin kolmimerkkisen luokan mukaan. 39 ICD-10:ssä sekä ICD-O:n 2. ja 3. laitoksessa on tarkemmat topografiakoodit. Multippelien kasvainten määrityksessä eräiden koodiryhmien tarkoittamat paikat katsotaan yhdeksi elimeksi. Nämä topografiakoodiryhmät on esitetty taulukossa 24. Monipesäkkeiset kasvaimet - ts. erilliset massat, jotka eivät vaikuta olevan muiden, samasta alkuperäpaikasta tai kudoksesta, esimerkiksi virtsarakosta, alkunsa saaneiden primaarikasvainten jatkoa - lasketaan yhdeksi syöväksi. Ihosyöpä on erityisen vaikea ongelma, koska samalla henkilöllä voi olla useita ihokasvaimia elämänsä aikana. IARC/IACR:n sääntöjen mukaan vain ensimmäinen tiettyä histologista tyyppiä oleva kasvain, olipa se missä tahansa iholla, huomioidaan syöväksi ilmaantuvuuslaskelmissa, ellei esimerkiksi ensimmäinen kasvain ole pahanlaatuinen melanooma ja toinen tyvisolukarsinooma. 4. Sääntöä 3 ei sovelleta kahdessa erityistapauksessa: 4.1 Tietyt systeemiset tai tyypillisesti useassa elimessä samanaikaisesti esiintyvät syövät (lymfoomat, leukemiat, Kaposin sarkooma ja mesoteliooma - taulukon 25 ryhmät 7, 8, 9 ja 10) lasketaan vain yhdeksi tapaukseksi potilasta kohden. 4.2 Muiden täsmällisesti määriteltyjen histologisten ryhmien kasvainten (taulukon 25 ryhmät 1-4, 6 ja 11) tulkitaan olevan ”erilaisia” multippeleja kasvaimia määriteltäessä. Jos siis samassa elimessä on kasvain, jolla on ”eri” histologia, se lasketaan uudeksi syöväksi. Ryhmien 5 ja 12 kasvaimille ei ole annettu täsmällistä histologista diagnoosia, eli niitä ei ole mahdollista erottaa muista ryhmistä. 40 Taulukko 24. ICD-O:n 2. ja 3. laitoksissa esiintyvät topografiakoodiryhmät, joita pidetään multippelien syöpien määrittelyssä yhtenä paikkana Toinen/kolmas laitos C01 Kielen tyvi C02 Kielen muu tai määrittämätön osa Ensimmäinen laitos 141 C05 C06 Suulaki Suun muu tai määrittämätön osa 145 C07 C08 Korvasylkirauhanen Suurten sylkirauhasten muu tai määrittämätön osa 142 C09 C10 Nielurisa Suunielu 146 C12 C13 Recessus piriformis Alanielu 148 C19 C20 Rectosigma Peräsuoli 154 C23 C24 Sappirakko Sappiteiden muu tai määrittämätön osa 156 C30 C31 Nenäontelo tai välikorva Nenän sivuontelot 160 C33 C34 Henkitorvi Keuhkoputki tai keuhko 162 C37 C38.0-3 C38.8 Kateenkorva Sydän ja mediastinum Eri alueisiin ulottuva sydämen, mediastinumin ja pleuran leesio C40 C41 Raajojen luut, nivelet tai nivelrustot Luun, nivelen tai nivelruston muu tai määrittämätön osa C51 C52 C57.7 C57.8-9 Vulva Vagina Naisen sukuelinten muu tai määrittämätön osa Eri alueisiin ulottuva naisen sukuelinten leesio ja naisen sukuelimet, NOS 184.4 184.0 184.9 184.8, 184.9 C56 C57.0 C57.1 C57.2 C57.3 C57.4 Munasarja Munanjohdin Kohdun leveä kannatin Kohtu-nivusside Parametrium Kohdun sivuelimet 183.0 183.2 183.3 183.5 183.4 183.9 C60 C63 Penis Miehen sukuelinten muu tai määrittämätön osa 187 41 164 164 165.8 170 Taulukko 24. jatkuu C64 C65 C66 C68 Munuainen Munuaisallas Virtsanjohdin Virtsaelinten muu tai määrittämätön osa 189 C74 C75 Lisämunuainen Muut umpirauhaset ja sentapaiset elimet 194.0 194 Taulukko 25. Pahanlaatuisten kasvaimien ryhmät, joita pidetään histologisesti ”erilaisina” multippelien tuumorien määrittelyssä (muokattu teoksesta Berg, 1994) (24) 1. 2. 3. Karsinoomat Levyepiteelikarsinoomat Tyvisolukarsinoomat Adenokarsinoomat 4. Muut määritetyt karsinoomat (5.) 6. Määrittämättömät karsinoomat (NOS) Sarkoomat ja pehmytkudostuumorit 7. 8. 9. 10. 11. Lymfoomat Leukemia Kaposin sarkooma Mesoteliooma Muut määritellyt syöpätyypit (12.) M-805-M-808, M-812, M-813 M-809-M-811 M-814, M-816, M-819–M-822, M-826–M833, M835–M-855, M-857, M-894 M-803, M-804, M-815, M-817, M-818, M-823–M-825, M-834, M-856, M-958–M-867 M-801,M-802 M-868–M-871, M-880–M-892, M-899, M-904, M912, M-913, M-915–925, M-937, M-954–M-958 M-959-M-972 M-980–M-994, M-914 M-905 M-872–M-879, M-900–M-903, M-938–M-953, M-800, M-997 Määrittämättömät syöpätyypit M-995, M-996, M-998 M-893, M-895–M-898, M-906–M-911, M-926–M-936, M-973–M-975, M-976 Rekistereissä voidaan noudattaa eri sääntöjä. Esimerkiksi Yhdysvalloissa useimmat rekisterit noudattavat Surveillance, Epidemiology and End Results (SEER) -ohjelman sääntöjä. Ne on esitetty yksityiskohtaisesti SEER Program Code Manual -käsikirjassa (25). SEER:n säännöissä otetaan huomioon diagnoosin ajankohta ja niissä lasketaan kukin paksunsuolen osa omaksi paikakseen, kun taas IARC:n säännöissä paksusuoli muodostaa yhden paikan. Histologian kannalta SEER:n säännöissä lasketaan kukin tietyssä paikassa esiintyvä kolmimerkkinen morfologiatyyppi yhdeksi syöväksi, kun taas IARC:n ohjeissa ”eri” histologia määritellään taulukossa 25 annettujen laajojen ryhmien perusteella. SEER Program Code Manual sisältää yli 25-sivuisen katsauksen ja ohjeistuksen multippelien lymfoomien ja leukemioiden eri yhdistelmien tulkitsemisesta ja koodaamisesta. Kunkin rekisterin on itse ratkaistava, minkä sääntöjen perusteella se käsittelee multippeleja kasvaimia. Tietojen esityksen yhteydessä käytetyt säännöt on kuvattava. 42 DIAGNOOSIPERUSTE ICD-O:n 1. laitoksessa oli mukana koodi M-9990/_, jolla voitiin luokitella ilman mikroskopiavahvistusta tehdyt diagnoosit. Useimmissa rekistereissä ei näitä koodeja kuitenkaan käytetty, joten ne on poistettu. Useiden kasvainten morfologiasta on mahdollista saada kohtalainen varmuus ilman histologista tutkimusta (esimerkkejä ovat retinoblastooma ja Kaposin sarkooma). Siksi suositellaan, että diagnoosin tekotapa osoitetaan muuttujalla, joka ei sisälly morfologiakoodiin. Yleisessä käytössä on useita diagnoosiperustetta osoittavia koodeja. Taulukossa 26 esitetään IARC:n ja IACR:n suosittelemat ”pätevin diagnoosiperuste”- koodit (26). Taulukko 26. IARC:n ja IACR:n diagnoosiperusteen koodit Koodi 0 Kuvaus Kriteeri Vain kuolintodistus Tieto saatu kuolintodistuksesta. Eimikroskooppinen 1 Kliininen Diagnoosi tehty ennen kuolemaa, mutta ilman seuraavia (koodit 2-7). 2 Kliininen tutkimus Kaikki diagnoositekniikat, mukaan luettuina röntgen, endoskopia, kuvantaminen, kaikukuvaus, kirurginen eksploraatio (esim. laparotomia), sekä ruumiinavaus, ilman kudosdiagnoosia. 4 Määritellyt kasvainmerkkiaineet Tähän sisältyvät biokemialliset ja/tai immunologiset merkkiaineet, jotka ovat ominaisia tietyille kasvainten sijaintipaikoille. Mikroskooppinen 5 Sytologia Primaari- tai sekundaaripaikan solujen tutkimus, myös endoskopialla tai neulalla aspiroitu neste sekä perifeerisestä verestä ja luuydinaspiraateista tehty mikroskooppitutkimus. 6 Etäpesäkkeen histologia Etäpesäkkeestä otetun kudoksen histologinen tutkimus, mukaan lukien ruumiinavausnäytteet. 8 Primaarikasvaimen histologia Primaarikasvaimesta saadun kudoksen histologinen tutkimus (saantitavasta riippumatta), johon sisältyvät kaikki leikkaustekniikat ja luuydinbiopsiat sekä myös primaarikasvaimesta ruumiinavauksessa otettu näyte. 9 Tuntematon ICD-O:n avulla on myös mahdollista osoittaa etäpesäkkeen histologian perusteella diagnosoidut kasvaimet käyttäytymiskoodeilla /6 (ja /9), joita syöpärekistereissä ei kuitenkaan käytetä (kts. kohta Käyttäytyminen, s. 30). Yhdysvalloissa useimmat rekisterit käyttävät North American Association of Central Cancer Registries -yhdistyksen ”diagnoosin vahvistus”-koodeja (27), joilla ilmoitetaan, perustuuko diagnoosi mikroskopiaan, sytologiaan, radiologiaan vai kliiniseen tietoon. 43 WHO:N KESKUSHERMOSTON KASVAINTEN PAHANLAATUISUUSASTEIKKO JA ICD-O-3:N ERILAISTUMISKOODI Vuonna 1993 WHO julkaisi keskushermoston kasvaimille pahanlaatuisuusasteikon (WHO grading system) (28, 29). Ensimmäisen (I) asteen kasvaimet ovat vähiten aggressiivisia ja IV asteen kasvaimet aggressiivisimpia. Jos tämä aste (WHO grade) on tiedossa, se voi helpottaa oikeiden ICD-O-3 histologia- ja käyttäytymiskoodien valintaa, kuten taulukossa 27 on esitetty. Tämä (WHO grade) luokittelu ei ole sama kuin ICD-O-3:n erilaistumisastetta osoittava koodi (6. merkki). WHO-asteikon avulla arvioidaan taudin ennustetta. Jos ICD-O-3:n erilaistumiskoodia (6. merkki) halutaan käyttää keskushermoston kasvainten yhteydessä, koodaajien on ensi sijassa otettava huomioon diagnoosissa käytetyt termit – esimerkiksi ”huonosti erilaistunut” tai ”anaplastinen” – ilmoitetun WHO-asteen sijasta. Monissa tapauksissa erilaistumisastetta ei ole kuvattu sanallisesti, ja silloin ICD-O-3:n mukainen erilaistuminen on osoitettava koodilla /9. Lisäksi ICD-O-3:ssa ei ole annettu erilaistumiskoodia hyvänlaatuisille tapauksille (/0) tai hyvän-/pahanlaatuisuudeltaan epävarmoille tapauksille (/1). Jos myös hyvänlaatuisia tai epävarmoja tapauksia rekisteröidään, niiden ICD-O-koodin 6. merkin tulee olla 9. TAULUKKO 27. WHO:N KEHITTÄMÄ KESKUSHERMOSTON KASVAINTEN PAHANLAATUISUUSASTEIKKO Koodattava kasvaintyyppi Astrosyyttiset kasvaimet (Astrosytoomat) Subependymaalinen jättisoluinen Pilosyyttinen Matala-asteinen (low grade) Pleomorfinen ksantoastrosytooma Anaplastinen Glioblastooma Oligodendroglioomat Matala-asteinen Anaplastinen Oligoastrosytoomat Matala-asteinen Anaplastinen Ependymaaliset kasvaimet (Ependymoomat) Subependymooma Myksopapillaarinen Matala-asteinen Anaplastinen Choroid plexus -kasvaimet Papillooma Karsinooma 44 WHO:n aste (grade) ICD-O:n koodi ICD-O:n käyttäytymiskoodi (5. merkki) I I II II–III III IV 9384 9421 9400 9424 9401 9440 1 1 3 3 3 3 II III 9450 9451 3 3 II III 9382 9382 3 3 I I II III 9383 9394 9391 9392 1 1 3 3 I III–IV 9390 9390 0 3 TAULUKKO 27 jatkuu. WHO:N KEHITTÄMÄ KESKUSHERMOSTON KASVAINTEN PAHANLAATUISUUSASTEIKKO Hermoston ja hermotukikudoksen kasvaimet Gangliosytooma Gangliogliooma Anaplastinen gangliogliooma Desmoplastinen infantiili gangliogliooma Dysembryoplastinen neuroepiteliaalinen kasvain Central neurocytoma Aivolisäkkeen kasvaimet Pineosytooma Pineaali-parenkymaalinen kasvain, kohtalaisen erilaistunut Pineoblastooma Embryonaaliset kasvaimet Medulloblastooma Muut PNET-kasvaimet Medulloepiteliooma Neuroblastooma Ependymoblastooma Kallonsisäiset ja selkäytimen hermokasvaimet Schwannooma Pahanlaatuinen ääreishermotupen kasvain Aivo- ja selkäydinkalvojen kasvaimet Meningiooma Epätyypillinen meningiooma Papillaarinen meningiooma Hemangioperisytooma Anaplastinen meningiooma 45 I I-II III I I 1 9492 9505 9505 9412 9413 9506 0 1 3 1 0 1 II 9361 1 III–IV IV 9362 9362 3 3 III III III III III 9470 9473 9501 9500 9392 3 3 3 3 3 I III–IV 9560 9540 0 3 I II II-III II-III III 9530 9539 9538 9150 9530 0 1 3 3 3 LÄHDELUETTELO 1. 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British Journal of Hematology, 1976, 33(4):451–458. 8. International histological classification of tumours, 2nd ed. Geneva, World Health Organization, 1981–2000. 9. International Statistical Classification of Diseases, Injuries, and Causes of Death. Sixth Revision. Geneva, World Health Organization, 1948. 10. Manual of tumor nomenclature and coding. New York, NY, American Cancer Society, 1951. 11. Systematized nomenclature of pathology. Chicago, IL, College of American Pathologists, 1965. 12. Manual of tumor nomenclature and coding. New York, NY, American Cancer Society, 1968. 13. International Statistical Classification of Diseases, Injuries and Causes of Death. Seventh Revision. Geneva, World Health Organization, 1957. 14. International Statistical Classification of Diseases, Injuries and Causes of Death. Eighth Revision. Geneva, World Health Organization, 1967. 15. International Classification of Diseases. Eighth Revision. Adapted for use in the United States. Washington, DC, US Department of Health, Education and Welfare, 1967 (Public Health Service Publication No. 1693). 16. Hospital Adaptation of International Classification of Diseases, Adapted. Ann Arbor, MI, Commission on Professional and Hospital Activities, 1968 (Library of Congress Card No. 68-56602). 46 17. International Statistical Classification of Diseases, Injuries, and Causes of Death. Ninth Revision. Clinical Modification. Washington, DC, US Department of Health and Human Services, 1979 (DHHS No. (PHS) 80-1260). 18. International Statistical Classification of Diseases, Injuries, and Causes of Death. Ninth Revision. Geneva, World Health Organization, 1977. 19. Thompson ET, Hayden AC, eds. Standard Nomenclature of Diseases and Operations, 5th ed. New York, McGraw-Hill, 1961. 20. Spackman KA, Campbell KE, Cote RA. SNOMED RT: A reference terminology for health care. Northfield, IL, College of American Pathologists, 2000. 21. Harris NL et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November 1997. Journal of Clinical Oncology, 1999, 17(12):3835–3849. 22. Harris NL et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November 1997. Annals of Oncology, 1999, 10(12):1419–1432. 23. The 1988 Bethesda System for reporting cervical/vaginal cytological diagnoses. Journal of the American Medical Association, 1989, 262(7):931–934. 24. Berg JW. Morphologic classification of human cancer. In: Shottenfeld D, Fraumeni J, Jr, eds. Cancer epidemiology and prevention, 2nd ed. New York, Oxford University Press, 1996 (Chapter 3). 25. SEER Program code manual, 3rd ed. Bethesda, MD, National Cancer Institute, 1998 (NIH Publication No. 98-2313). 26. Jensen OM et al., eds. Cancer registration: principles and methods. Lyon, International Agency for Research on Cancer, 1989 (IARC Scientific Publications, No. 95). 27. Seiffert JE, ed. Standards for cancer registries, Vol. II: Data standards and data dictionary. Springfield, IL, North American Association of Central Cancer Registries, 1998. 28. Kleihues P, Burger PC, Scheithauer BW. Histological typing of tumours of the central nervous system (International Histological Classification of Tumours). Berlin, Springer Verlag, 1993. 29. Kleihues P, Cavenee WK, eds. Pathology and genetics of tumours of the nervous system. Lyon, International Agency for Research on Cancer, 1997. 47 48 NUMEERISET LUETTELOT 49 TOPOGRAFIA Huom. Kategorioissa C00-C80.9 kasvaimille etsitään sellainen alakategoria, joka sisältää tuumorin alkuperäpaikan. Useamman alakategorian rajat ylittävä tuumori, jonka alkuperäpaikkaa ei voida määrittää, laitetaan alakategoriaan ”.8”. Esim. Cervicothorakaalinen ruokatorven kasvain koodattaisiin kategoriaan C15.8. C00-C14 HUULI, SUUONTELO TAI NIELU C01 KIELEN TYVI C01.9 C00 HUULI (ei sisällä huulen ihoa C44.0) C00.0 Ylähuulen ulkopinta Labium superius Ylähuulen punaosa Ylähuuli, NOS (ei sisällä ylähuulen ihoa C44.0) C00.1 Alahuulen ulkopinta Alahuulen punaosa Alahuuli, NOS (ei sisällä alahuulen ihoa C44.0) Labium inferius C00.2 Huulen ulkopinta, NOS Huulen punaosa, NOS C00.3 Ylähuulen limakalvo Frenulum labii superioris Ylähuulen sisäpinta C00.4 Alahuulen limakalvo Alahuulen sisäpinta Frenulum labii inferioris C00.5 Huulen limakalvo, NOS Huulen frenulum, NOS Huulen sisäpinta, NOS C00.6 Suupieli Commissura labiorum oris C00.8 Eri alueisiin ulottuva huulen leesio (katso huomautus sivulta 45) C00.9 Huuli, NOS (ei sisällä huulen ihoa C44.0) Labium, NOS Kielen tyvi, NOS Kielen takakolmannes Kielen takaosa, NOS Kielen tyven yläpinta C02 KIELEN MUU TAI MÄÄRITTÄMÄTÖN OSA 50 C02.0 Kielen yläpinta, NOS Kielen etuosan yläpinta Kielen kahden etumaisen kolmanneksen yläpinta Kielen keskiviiva C02.1 Kielen reuna Kielen kärki C02.2 Kielen alapinta, NOS Frenulum linguae Kielen etuosan alapinta, NOS Kielen kahden etumaisen kolmanneksen alapinta Kieliside C02.3 Kielen kaksi etukolmannesta, NOS Kielen etuosa, NOS C02.4 Kielirisa Tonsilla lingualis C02.8 Eri alueisiin ulottuva kielen leesio (katso huomautus sivulta 50) C02.9 Kieli, NOS Lingua, NOS Topografianumerot (jatkuu) C05.1 Yläien Gingiva maxillaris Yläleuan hammaskuopan limakalvo Yläleuan hammaskuoppa Yläleuan hammaskuoppaharjanteen limakalvo Pehmeä suulaki, NOS (ei sisällä pehmeän suulaen nenänielupinta C11.3) Palatum molle C05.2 Kitakieleke Uvula palatina C05.8 Alaien Alaleuan hammaskuopan limakalvo Alaleuan hammaskuoppa Alaleuan hammaskuoppaharjanteen limakalvo Gingiva mandibularis Eri alueisiin ulottuva suulaen leesio (katso huomautus sivulta 50) Kovan ja pehmeän suulaen rajakohta C05.9 Suulaki, NOS Palatum, NOS C03 IEN C03.0 C03.1 C03.9 C06 SUUN MUU TAI MÄÄRITTÄMÄTÖN OSA Ien, NOS Alveolus, NOS Gingiva, NOS Hammaskuopan limakalvo,NOS Hammaskuoppa, NOS Hammaskuoppaharjanteen limakalvo, NOS C04 SUUNPOHJA C04.0 Suunpohjan etuosa C04.1 Suunpohjan sivuosa C04.8 Eri alueisiin ulottuva suunpohjan leesio (katso huomautus sivulta 50) C04.9 Suunpohja, NOS Basis oris, NOS C05 SUULAKI C05.0 Kova suulaki Palatum durum 51 C06.0 Posken limakalvo Mucosa buccalis Posken sisäpuoli C06.1 Suun eteinen Vestibulum oris C06.2 Poskihampaan takainen alue Trigonum retromolare C06.8 Eri alueisiin ulottuva muu tai määrittämätön suun osan leesio (katso huomautus sivulta 50) C06.9 Suu, NOS Cavitas oris Pieni sylkirauhanen, NOS (katso huomautus C08:n alta) Suun limakalvo Suuontelo Topografianumerot (jatkuu) C09.9 C07 KORVASYLKIRAUHANEN C07.9 Korvasylkirauhanen Ductus parotideus Glandula parotidea Korvasylkirauhasen tiehyt Parotis, NOS Stensenin tiehyt C10 SUUNIELU C08 SUURTEN SYLKIRAUHASTEN MUU TAI MÄÄRITTÄMÄTÖN OSA Huom. Pienten sylkirauhasten kasvaimet tulee luokitella anatomisen sijaintipaikkansa mukaan, jos sijainniltaan määrittämätön, luokitellaan C06.9. C08.0 Leuanalussylkirauhanen Ductus submandibularis Glandula submandibularis Leuanalussylkirauhasen tiehyt Whartonin tiehyt C08.1 Kielenalussylkirauhanen Ductus sublinguales Glandula sublingualis Kielenalussylkirauhasen tiehyet C08.8 Eri alueisiin ulottuva suurten sylkirauhasten leesio (katso huomautus sivulta 50) C08.9 Suuri sylkirauhanen, NOS Sylkirauhanen, NOS (ei sisällä pieni sylkirauhanen, NOS C06.9; katso huomautus C08:n alta) C10.0 Kurkunkannenkuoppa Vallecula epiglottica C10.1 Kurkunkannen etupinta Epiglottiksen etupinta C10.2 Suunielun sivuseinä C10.3 Suunielun takaseinä C10.4 Kidustasku (kasvaimen sijaintipaikkana) Brankiaalikysta (kasvaimen sijaintipaikkana) Cysta branchiogenes (kasvaimen sijaintipaikkana) C10.8 Eri alueisiin ulottuva suunielun leesio (katso huomautus sivulta 50) C10.9 Suunielu, NOS Faux, NOS Mesopharynx, NOS Oropharynx, NOS C11 NENÄNIELU C11.0 Nenänielun katto C11.1 Nenänielun takaseinä Kitarisa Tonsilla pharyngealis C11.2 Nenänielun sivuseinä Recessus pharyngeus Rosenmüllerin kuoppa C11.3 Nenänielun etuseinä Choana Nenän väliseinän takareunus Nenä-nieluaukko Pehmeän suulaen nenänielupinta C09 NIELURISA C09.0 Nielurisakuoppa Fossa tonsillaris C09.1 Kitakaari Arcus palatoglossus C09.8 Nielurisa, NOS (ei sisällä kielirisaa C02.4 ja kitarisaa C11.1) Tonsillae palatinae Eri alueisiin ulottuva nielurisan leesio (katso huomautus sivulta 50) 52 Topografianumerot (jatkuu) C11.8 Eri alueisiin ulottuva nenänielun leesio (katso huomautus sivulta 50) C11.9 Nenänielu, NOS Nasopharynx, NOS Nenänielun seinä C14.8 C12 RECESSUS PIRIFORMIS C12.9 C15-C26 RUUANSULATUSELIMET Recessus piriformis Fossa piriformis C15 RUOKATORVI C13 ALANIELU C13.0 Rengasrustontakainen alue Cricoideus, NOS C13.1 Kurkunpään eteispoimun alanielun puoleinen osa Alanielun puoleinen osa aryepiglottista Kurkunpään eteispoimu, NOS (ei sisällä kurkunpään eteispoimun kurkunpään puoleista osaa C32.1) C13.2 Alanielun takaseinä C13.8 Eri alueisiin ulottuva alanielun leesio (katso huomautus sivulta 50) C13.9 Alanielu, NOS Alanielun seinä Hypopharynx, NOS C15.0 Ruokatorven kaulaosa C15.1 Ruokatorven rintakehäosa C15.2 Ruokatorven vatsaosa C15.3 Ruokatorven yläkolmannes C15.4 Ruokatorven keskikolmannes C15.5 Ruokatorven alakolmannes C15.8 Eri alueisiin ulottuva ruokatorven leesio (katso huomautus sivulta 50) C15.9 Ruokatorvi, NOS Oesophagus, NOS C16 MAHALAUKKU C16.0 Mahansuu, NOS Cardia, NOS Gastroesofageaalinen junktio Junctio oesophagogastrica Ostium cardiacum Ruokatorven ja mahalaukun rajaalue C16.1 Mahanpohjukka Fundus gastricus C16.2 Mahanrunko Corpus gastricum C14 HUULEN, SUUONTELON TAI NIELUN MUU TAI SIJAINNILTAAN MÄÄRITTÄMÄTÖN OSA C14.0 C14.2 Eri alueisiin ulottuva huulen, suuontelon ja nielun leesio Huom. Huulen, suuontelon tai nielun kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C00C14.2. Nielu, NOS Kurkku Nielun seinä, NOS Pharynx, NOS Nielun risarengas Waldeyerin nielurengas 53 Topografianumerot (jatkuu) C16.3 Mahanportin soppi Antrum pyloricum C16.4 Mahanportti Pylorus Canalis pyloricus C16.5 C16.6 C16.8 C16.9 C17.0 C18 KOOLON C18.0 Umpisuoli Caecum Ileosekaaliläppä C18.1 Umpilisäke Appendix vermiformis C18.2 Koolonin nouseva osa Colon ascendens C18.3 Koolonin oikea mutka Flexura hepatica C18.4 Koolonin poikittainen osa Colon transversum C18.5 Koolonin vasen mutka Flexura lienalis C18.6 Koolonin laskeva osa Colon descendens Mahalaukku, NOS Gaster, NOS Ventriculus, NOS C18.7 Sigmasuoli Colon sigmoideum Vemmelsuoli C17 OHUTSUOLI C18.8 Eri alueisiin ulottuva koolonin leesio (katso huomautus sivulta 50) Duodenum Pohjukaissuoli C18.9 Koolon, NOS (ei sisällä peräsuoli, NOS C20.9 eikä rectosigmaa C19.9) Intestinum crassum, NOS Lynkkysuoli Paksusuoli, NOS (ei sisällä peräsuoli, NOS C20.9 eikä rectosigmaa C19.9) Mahalaukun pieni kaarre, NOS (ei luokiteltavissa C16.1-C16.4) Curvatura minor Mahalaukun iso kaarre, NOS (ei luokiteltavissa C16.0-C16.4) Curvatura major Eri alueisiin ulottuva mahalaukun leesio (katso huomautus sivulta 50) Mahalaukun etuseinä, NOS (ei luokiteltavissa C16.0-C16.4) Mahalaukun takaseinä, NOS (ei luokiteltavissa C16.0-C16.4) C17.1 Jejunum Tyhjäsuoli C17.2 Ileum (ei sisällä ileosekaaliläppää C18.0) Sykkyräsuoli C17.3 Meckelin divertikkeli (kasvaimen sijaintipaikkana) Meckelin umpipussi (kasvaimen sijaintipaikkana) Diverticulum Meckel (kasvaimen sijaintipaikkana) C17.8 Eri alueisiin ulottuva ohutsuolen leesio (katso huomautus sivulta 50) C17.9 Ohutsuoli, NOS Intestinum tenue, NOS C19 RECTOSIGMA C19.9 54 Rectosigma Peräsuolen ja sigmasuolen rajaalue Topografianumerot (jatkuu) C24 SAPPITEIDEN MUU TAI MÄÄRITTÄMÄTÖN OSA C20 PERÄSUOLI C20.9 Peräsuoli, NOS Rectum, NOS C24.0 Maksanulkoiset sappitiet Ductus biliaris, NOS Ductus choledochus Ductus cysticus Ductus hepaticus communis Sappitiehyt, NOS Sphincter Oddi C24.1 Ampulla Vateri Papilla Vateri Sapenjohtimen ja haimatiehyen yhteisen osan avartuma C24.8 Eri alueisiin ulottuva sappiteiden leesio Huom. Kasvain, joka kasvaa sekä maksansisäisissä että maksanulkoisissa sappiteissä. (katso myös huomautus sivulta 50) C24.9 Sappitiet, NOS C21 PERÄAUKKO TAI PERÄAUKKOKANAVA C21.0 C21.1 Peräaukko, NOS (ei sisällä anuksen ihoa ja perianaalista ihoa C44.5) Anus, NOS Peräaukkokanava Canalis analis Musculus sphincter ani C21.2 Kloakogeeninen alue C21.8 Eri alueisiin ulottuva peräsuolen, peräaukon ja peräaukkokanavan leesio (katso huomautus sivulta 50) C25 HAIMA C22 MAKSA TAI MAKSANSISÄISET SAPPITIET C22.0 C22.1 C25.0 Haiman pää Caput pancreatis Maksa Hepar C25.1 Haiman runko Corpus pancreatis Maksansisäiset sappitiet Canaliculi biliferi C25.2 Haiman häntä Cauda pancreatis C25.3 Haimatiehyt Ductus pancreatis Santorinin tiehyt Wirsungin tiehyt C25.4 Langerhansin saarekkeet Endokriininen haima Haiman umpirauhasosa Haimasaarekkeet Insulae pancreaticae C25.7 Haiman muu määritetty alue Haiman kaula C23 SAPPIRAKKO C23.9 Sappirakko Vesica biliaris Vesica fellea 55 Topografianumerot (jatkuu) C25.8 Eri alueisiin ulottuva haiman leesio (katso huomautus sivulta 50) C25.9 Haima, NOS Pancreas, NOS C30.1 Välikorva Antrum mastoideum Cavitas tympani Kartiolisäkkeen eteislokero Korvatorvi Sisäkorva Tuba auditiva Täryontelo C26 RUUANSULATUSELINTEN MUU TAI SIJAINNILTAAN MÄÄRITTÄMÄTÖN OSA C26.0 C26.8 C26.9 C31 NENÄN SIVUONTELOT Suolikanava, NOS Suoli, NOS Tractus intestinalis, NOS Eri alueisiin ulottuva ruuansulatuselinten leesio Huom. Ruuansulatuselinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C15-C26.0. (katso myös huomautus sivulta 50) Ruuansulatuselimistö, NOS Ruuansulatuselimet, NOS Ruuansulatuskanava, NOS Tractus digestorius, NOS C30-C39 HENGITYSELIMISTÖ TAI RINTAKEHÄN ELIMET C31.0 Poskiontelo Sinus maxillaris C31.1 Seulalokerosto Sinus ethmoidalis C31.2 Otsaontelo Sinus frontalis C31.3 Kitaluun ontelo Sinus sphenoidalis C31.8 Eri alueisiin ulottuva nenän sivuonteloiden leesio (katso huomautus sivulta 50) C31.9 Nenän sivuontelo, NOS Sivuontelo, NOS C30 NENÄONTELO TAI VÄLIKORVA C30.0 Nenäontelo (ei sisällä nenä, NOS C76.0) Cavum nasi Concha nasalis Nenäkuorikko Nenän eteinen Nenän limakalvo Nenän rustot Nenän väliseinä, NOS (ei sisällä nenän väliseinän takareunusta C11.3) Septum nasi, NOS (ei sisällä nenän väliseinän takareunusta C11.3) Sierain Vestibuli nasi C32 KURKUNPÄÄ C32.0 56 Äänielin Glottis Kurkunpään sisäosat Plica vocalis Äänihuuli, NOS Äänirako Topografianumerot (jatkuu) C32.1 C32.2 C32.3 C34 KEUHKOPUTKI TAI KEUHKO Ääniraon yläpuolinen kurkunpää Epiglottis, NOS (ei sisällä kurkunkannen etupintaa C10.1) Kurkunkannen takapinta Kurkunkansi, NOS (ei sisällä kurkunkannen etupintaa C10.1) Kurkunpään eteispoimun kurkunpään puoleinen osa Kurkunpään puoleinen osa aryepiglottista Kurkunpään ulko-osat Ligamentum vestibulare Plica vestibularis Supraglotticus Taskuhuuli Taskujänne Ääniraon alapuolinen kurkunpää Subglotticus Kurkunpään rustot Cartilago arytaenoidea Cartilago cricoidea Cartilago cuneiformis Cartilago thyreoidea Kannurusto Kiilanmuotoinen rusto Kilpirusto Rengasrusto C34.0 Pääkeuhkoputki Bronchus principalis Carina tracheae Hilum pulmonis Keuhkoportti Pääbronchus C34.1 Keuhkon ylälohko Keuhkon ylälohkon keuhkoputki Keuhkonkieleke Lingula pulmonis sinistri C34.2 Keuhkon keskilohko Keuhkon keskilohkon keuhkoputki C34.3 Keuhkon alalohko Keuhkon alalohkon keuhkoputki C34.8 Eri alueisiin ulottuva keuhkon leesio (katso huomautus sivulta 50) C34.9 Keuhko, NOS Keuhkoputki, NOS C37 KATEENKORVA C37.9 C32.8 Eri alueisiin ulottuva kurkunpään leesio (katso huomautus sivulta 50) C32.9 Kurkunpää, NOS Larynx, NOS C38 SYDÄN, MEDIASTINUM TAI PLEURA C38.0 C33 HENKITORVI C33.9 Kateenkorva Thymus Henkitorvi Trachea 57 Sydän Atrium cordis Endocardium Epicardium Myocardium Pericardium Sydämen sisäkalvo Sydäneteinen Sydänkammio Sydänlihas Sydänpussi Ventriculus cordis Topografianumerot (jatkuu) C38.1 Etumediastinum Välikarsinan etuosa C38.2 Takamediastinum Välikarsinan takaosa C38.3 Mediastinum, NOS Välikarsina, NOS C38.4 Keuhkopussi, NOS Pleura, NOS Pleura parietalis Pleura visceralis C38.8 Eri alueisiin ulottuva sydämen, mediastinumin ja keuhkopussin leesio (katso huomautus sivulta 50) C40-C41 LUUT, NIVELET TAI NIVELRUSTOT C40 RAAJOJEN LUUT, NIVELET TAI NIVELRUSTOT C40.0 Yläraajan pitkät luut, lapaluu ja niiden nivelet Hartiakaari Humerus Kyynärnivel Käden luu Käsivarren luu Olkalisäke-solisluunivel Olkanivel Radius Scapula Ulna C40.1 Yläraajan lyhyet luut ja niiden nivelet Kämmenen luu Metakarpaaliluu Os metacarpale Ossa carpi Phalanges manus Ranneluut Rannenivel Sormen luu C40.2 Alaraajan pitkät luut ja niiden nivelet Femur Fibula Jalan luu Meniscus Nivelkierukka Polvinivel, NOS Tibia C40.3 Alaraajan lyhyet luut ja niiden nivelet Jalkapöydän luu Metatarsaaliluu Nilkkaluut Nilkkanivel Ossa tarsalia Patella Phalanges pedis Polvilumpio Varpaan luu C39 HENGITYS- TAI RINTAONTELON ELINTEN MUU TAI SIJAINNILTAAN MÄÄRITTÄMÄTÖN OSA C39.0 Ylähengitystiet, NOS C39.8 Eri alueisiin ulottuva hengityselinten ja muiden rintaontelon elinten leesio Huom. Hengityselinten tai muiden rintaontelon elinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C30-C39.0. C39.9 Hengityselinten sijainniltaan määrittämätön osa Hengitystiet, NOS Tractus respiratorius, NOS 58 Topografianumerot (jatkuu) C40.8 Eri alueisiin ulottuva raajan luun, nivelen ja nivelruston leesio (katso huomautus sivulta 50) C40.9 Raajan luu, NOS Raajan nivel, NOS Raajan nivelrusto, NOS C41.3 Kylkiluu, rintalasta, solisluu ja nivelrustot Clavicula Costa Kylkiluu-poikkihaarakenivel Kylkirusto Rintalasta-kylkiluunivel Sternum C41.4 Lantion luut, ristiluu, häntäluu ja nivelrustot Acetabulum Häpyliitos Istuinluu Lonkkaluu Lonkkamalja Os coccygis Os coxae Os ilium Os ischii Os sacrum Suoliluu Symphysis pubica C41.8 Eri alueisiin ulottuva luun, nivelen tai nivelruston leesio Huom. Luiden, nivelten ja nivelrustojen kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C40 tai C41. C41.9 Luu, NOS Nivel, NOS Rusto, NOS C41 LUUN, NIVELEN TAI NIVELRUSTON MUU TAI MÄÄRITTÄMÄTÖN OSA C41.0 C41.1 C41.2 Kallon ja kasvon luut ja nivelrustot (ei sisällä alaleukaluuta C41.1) Maxilla Os ethmoidale Os frontale Os hyoideum Os nasale Os occipitale Os parietale Os sphenoidale Os temporale Os zygomaticum Pääkallo, NOS Yläleukaluu Alaleukaluu Mandibula Leukaluu, NOS Leukanivel Selkäranka (ei sisällä risti- ja häntäluuta C41.4) Atlas Axis Discus intervertebralis Kannattajanikama Kiertonikama Nikama Nikamavälilevy Vertebra C42 HEMATOPOEETTINEN TAI RETIKULOENDOTELIAALISYSTEEMI 59 C42.0 Veri Haema C42.1 Luuydin Medulla ossium C42.2 Perna Lien Topografianumerot (jatkuu) C42.3 Retikuloendoteliaalisysteemi, NOS C42.4 Hematopoeettinen systeemi, NOS C44.4 Päälaen, kaulan tai niskan iho Pään iho, NOS Solisluun yläpuolen iho Supraclaviculaarinen iho C44.5 Vartalon iho anuksen iho kainalon iho kyljen iho mahan iho nivusalueen iho pakaran iho perineumin iho rintakehän iho selän iho vatsan iho Napa, NOS Perianaalinen iho Umbilicus, NOS C44.6 Yläraajan tai hartian iho kyynärpään iho käden iho olkapään iho ranteen iho sormen iho Sormen kynsi C44.7 Alaraajan tai lonkan seudun iho jalan iho nilkan iho polven iho varpaan iho Varpaan kynsi C44.8 Eri alueisiin ulottuva ihon leesio (katso huomautus sivulta 50) C44.9 Iho, NOS (ei sisällä ison häpyhuulen ihoa C51.0, vulvan ihoa C51.9, peniksen ihoa C60.9, kivespussin ihoa C63.2) C44 IHO (ei sisällä ulkosynnyttimien ihoa C51._, peniksen ihoa C60.9, kivespussin ihoa C63.2) C44.0 Huulen iho, NOS Alahuulen iho Ylähuulen iho C44.1 Silmäluomi Canthus, NOS Luomi, NOS Meibomin rauhanen Silmäkulma, NOS C44.2 C44.3 Ulkokorva Auricula, NOS Auris externa Concha auriculae Glandula ceruminosa Helix Korva, NOS Korvakäytävä, NOS Korvalehti, NOS Pinna auris Tragus Kasvojen ihon muu tai määrittämätön osa leuan iho nenän iho otsan iho posken iho Ala nasi Columella nasi Kulmakarva Leuka, NOS Nenänsiiveke Ohimo, NOS Otsa, NOS 60 Topografianumerot (jatkuu) C47 ÄÄREISHERMOT TAI AUTONOMINEN HERMOSTO (sisältää autonominen hermosto, gangliat, hermot, parasympaattinen hermosto, selkäydinhermot, sympaattinen hermosto, ääreishermot) C47.0 C47.1 Pään, kasvojen, kaulan tai niskan ääreishermot tai autonominen hermosto (ei sisällä silmäkuopan C69.6 autonomista hermostoa tai ääreishermoja) Ääreishermot tai autonominen hermosto (katso lista C47:n alta): Fossa pterygoidea leuan ohimon otsan posken päälaen solisluun yläpuolen Kaulapunos Plexus cervicalis Yläraajan tai hartian ääreishermot tai autonominen hermosto Ääreishermot tai autonominen hermosto (katso lista C47:n alta): kyynärpään käden olkapään ranteen sormen Hartiapunos Nervus medianus Nervus radialis Nervus ulnaris Plexus brachialis 61 C47.2 Alaraajan tai lonkan seudun ääreishermot tai autonominen hermosto Ääreishermot tai autonominen hermosto (katso lista C47:n alta): jalan nilkan polven varpaan Nervus femoralis Nervus ischiadicus Nervus obturatorius C47.3 Rintakehän ääreishermot tai autonominen hermosto Ääreishermot tai autonominen hermosto (katso lista C47:n alta): kainalon lapaluun alueen solisluun alapuolen Nervus intercostalis C47.4 Vatsan ääreishermot tai autonominen hermosto Ääreishermot tai autonominen hermosto (katso lista C47:n alta): navan vatsanpeitteiden C47.5 Lantion ääreishermot tai autonominen hermosto Ääreishermot tai autonominen hermosto (katso lista C47:n alta): nivusalueen pakaran perineumin ristiselän Nervus sacralis Plexus lumbosacralis Plexus sacralis Ristipunos C47.6 Vartalon ääreishermot tai autonominen hermosto, NOS Ääreishermot tai autonominen hermosto (katso lista C47:n alta): kyljen selän Nervus lumbalis Topografianumerot (jatkuu) C47.8 Eri alueisiin ulottuva ääreishermon tai autonomisen hermoston leesio (katso huomautus sivulta 50) C47.9 Autonominen hermosto, NOS Ganglia, NOS Hermo, NOS Parasympaattinen hermosto, NOS Selkäydinhermo, NOS Sympaattinen hermosto, NOS Ääreishermo, NOS C49 SIDEKUDOKSET TAI MUUT PEHMYTKUDOKSET (sisältää bursa, faskia, ihonalaiskudos, imu- ja verisuonet, jänne, jännetuppi, lihas- ja rasvakudokset, synovia) C49.0 Pään, kasvojen, kaulan tai niskan side- tai pehmytkudos (ei sisällä nenän rustoja C30.0 eikä orbitan sidekudoksia C69.6) Side- tai pehmytkudos (katso lista C49:n alta): Fossa pterygoidea leuka ohimo otsa poski päälaki solisluun yläpuoli Arteria carotis Korvan rustot Musculus masseter Musculus sternocleidomastoideus C49.1 Yläraajan tai hartian side- tai pehmytkudos Side- tai pehmytkudos (katso lista C49:n alta): kyynärpää käsi olkapää ranne sormi Aponeurosis palmaris Arteria radialis Arteria ulnaris Musculus biceps brachii Musculus brachialis Musculus coracobrachialis Musculus deltoideus Musculus triceps brachii C48 VATSAKALVO TAI SEN TAKAINEN TILA C48.0 Retroperitoneum Periadrenaalinen kudos Peripankreaattinen kudos Perirenaalinen kudos Retrosekaalinen kudos Retroperitoneaalinen kudos Vatsakalvontakaisen tilan kudos C48.1 Vatsakalvon määritetty osa Fossa Douglasi Mesenterium Mesoappendix Mesocolon Omentti Suolilieve (katso huomautus sivulta 50) C48.2 Vatsakalvo, NOS Peritoneum, NOS Vatsakalvonontelo C48.8 Eri alueisiin ulottuva vatsakalvon ja sen takaisen tilan leesio (katso huomautus sivulta 50) Eri alueisiin ulottuva retroperitoneumin ja peritoneumin leesio 62 Topografianumerot (jatkuu) C49.2 C49.3 C49.4 Alaraajan tai lonkan seudun side- tai pehmytkudos Side- tai pehmytkudos (katso lista C49:n alta): jalka nilkka polvi varvas Aponeurosis plantaris Arteria femoralis Musculus biceps femoris Musculus gastrocnemius Musculus quadriceps femoris Rintakehän side- tai pehmytkudos (ei sisällä kateenkorvaa C37.9, sydäntä ja mediastinumia C38._) Side- tai pehmytkudos (katso lista C49:n alta): kainalo lapaluun alue solisluun alapuoli Aortta, NOS Arteria axillaris Arteria subclavia Arteria thoracica interna Ductus thoracicus Musculi intercostales Musculus latissimus dorsi Musculus pectoralis major Musculus trapezius Pallea Vena cava superior C49.5 Lantion side- tai pehmytkudos Side- tai pehmytkudos (katso lista C49:n alta): nivusalue pakara perineum ristiselkä Arteria iliaca Musculus gluteus maximus Vena iliaca C49.6 Vartalon side- tai pehmytkudos, NOS Side- tai pehmytkudos (katso lista C49:n alta): kylki selkä C49.8 Eri alueisiin ulottuva side- tai pehmytkudoksen leesio (katso huomautus sivulta 50) C49.9 Side- tai pehmytkudos, NOS Bursa, NOS Jänne, NOS Lihas, NOS Rasvakudos, NOS Verisuoni, NOS C50 RINTA (ei sisällä rinnan ihoa C44.5) Vatsan side- tai pehmytkudos Side- tai pehmytkudos (katso lista C49:n alta): napa vatsanpeitteet Aorta abdominalis Arteria mesenterica Arteria renalis Musculus iliopsoas Musculus psoas Musculus rectus abdominis Truncus coeliacus Vinot vatsalihakset Vena cava inferior Vena cava, NOS 63 C50.0 Nänni Mamilla C50.1 Rinnan keskiosa C50.2 Rinnan yläsisäneljännes C50.3 Rinnan alasisäneljännes C50.4 Rinnan yläsivuneljännes C50.5 Rinnan alasivuneljännes C50.6 Rinnan kainaloon suuntautuva osa Topografianumerot (jatkuu) C50.8 C50.9 C53 KOHDUNKAULA Eri alueisiin ulottuva rinnan leesio (katso huomautus sivulta 50) Rinnan alaosa Rinnan keskiviiva Rinnan sivu Rinnan yläosa C53.0 Endocervix Kohdun kaulakanavan sisäosa Nabothin rauhanen C53.1 Kohdunnapukka Exocervix Kohdunsuu Ostium uteri Portio C53.8 Eri alueisiin ulottuva kohdunkaulan leesio (katso huomautus sivulta 50) Kohdunkaulan muuntumisalue Kohdunkaulan tynkä C53.9 Kohdunkaula Cervix uteri Cervix, NOS Rinta, NOS Glandula mammaria C51-C58 NAISEN SUKUELIMET C51 VULVA C51.0 Iso häpyhuuli Bartholinin rauhanen Ison häpyhuulen iho Labium majus pudendi C51.1 Pieni häpyhuuli Labium minus pudendi C54 KOHDUNRUNKO C51.2 Clitoris Häpykieli C54.0 Isthmus uteri Kohdunsola C51.8 Eri alueisiin ulottuva vulvan leesio (katso huomautus sivulta 50) C54.1 Endometrium Kohdunrungon limakalvo C51.9 Vulva, NOS Häpyhuuli, NOS Ulkosynnyttimet, NOS Vulvan iho C54.2 Myometrium Kohdunrungon lihaskerros C54.3 Fundus uteri Kohdunpohja C54.8 Eri alueisiin ulottuva kohdunrungon leesio (katso huomautus sivulta 50) C54.9 Kohdunrunko Corpus uteri C52 VAGINA C52.9 Vagina, NOS Emätin, NOS Fornix vaginae Gartnerin tiehyt Hymen Immenkalvo C55 KOHTU, NOS C55.9 64 Kohtu, NOS Uterus, NOS Topografianumerot (jatkuu) C56 MUNASARJA C56.9 C60-C63 MIEHEN SUKUELIMET Munasarja Ovario C60 PENIS C57 NAISEN SUKUELINTEN MUU TAI MÄÄRITTÄMÄTÖN OSA C60.0 Esinahka Preputium C60.1 Terska Glans penis C57.0 Munanjohdin Tuba uterina C60.2 Peniksen runko Siittimen runko C57.1 Kohdun leveä kannatin Ligamentum latum uteri C60.8 Eri alueisiin ulottuva peniksen leesio (katso huomautus sivulta 50) C57.2 Kohtu-nivusside Ligamentum rotundum uteri C60.9 Penis, NOS Peniksen iho C57.3 Parametrium Kohdunvieruskudos Ligamentum rectouterinum Ligamentum sacrouterinum Peräsuoli-kohtuside C57.4 Kohdun sivuelimet Adnexa uteri Adnexa, NOS C57.7 Naisen muu määritetty sukuelinten osa Wolffin tiehyt C57.8 C57.9 C61 ETURAUHANEN C61.9 C62 KIVES Eri alueisiin ulottuva naisen sukuelinten leesio Huom. Naisen sukuelinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C51- C57.7 tai C58. Naisen sukuelimet, NOS Septum urethrovaginale Vesicocervikaalinen kudos C58 ISTUKKA C58.9 Eturauhanen Glandula prostatica Prostata, NOS Istukka Membrana fetalis Placenta Sikiökalvot 65 C62.0 Laskeutumaton kives (kasvaimen sijaintipaikkana) Testis ectopicus (kasvaimen sijaintipaikkana) C62.1 Laskeutunut kives C62.9 Kives, NOS Testis, NOS Topografianumerot (jatkuu) C67 VIRTSARAKKO C63 MIEHEN SUKUELINTEN MUU TAI MÄÄRITTÄMÄTÖN OSA C67.0 Virtsarakon kolmio Trigonum vesicae C67.1 Virtsarakon pohja Fundus vesicae C67.2 Virtsarakon sivuseinä C67.3 Virtsarakon etuseinä C67.4 Virtsarakon takaseinä C67.5 Virtsarakon kaula Virtsaputken sisäsuu Ostium urethrae internum C67.6 Virtsanjohtimen aukko Ostium ureteris Eri alueisiin ulottuva miehen sukuelinten leesio Huom. Miehen sukuelinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C60-C63.7. C67.7 Urakus C67.8 Eri alueisiin ulottuva virtsarakon leesio (katso huomautus sivulta 50) Miehen sukuelimet, NOS C67.9 Virtsarakko, NOS Vesica urinaria, NOS C63.0 Lisäkives Epididymis C63.1 Siemennuora Funiculus spermaticus Siemenjohdin Vas deferens C63.2 C63.7 C63.8 C63.9 Kivespussi, NOS Kivespussin iho Scrotum, NOS Miehen muu määritetty sukuelinten osa Glandula seminalis Rakkularauhanen Tunica vaginalis C64-C68 VIRTSATIET C68 VIRTSAELINTEN MUU TAI MÄÄRITTÄMÄTÖN OSA C64 MUNUAINEN C64.9 Munuainen, NOS Ren, NOS C65 MUNUAISALLAS C65.9 Munuaisallas Pelvis renalis C68.0 Virtsaputki Bulbouretraalirauhanen Cowberin rauhanen Urethra Utriculus prostaticus C68.1 Virtsaputken vierusrauhaset Glandula paraurethralis C68.8 Eri alueisiin ulottuva virtsaelinten leesio Huom. Virtsaelinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C64-C68.1. C68.9 Virtsatiet, NOS C66 VIRTSANJOHDIN C66.9 Virtsanjohdin Ureter 66 Topografianumerot (jatkuu) C69-C72 SILMÄ, AIVOT TAI MUUT KESKUSHERMOSTON OSAT C69.8 Eri alueisiin ulottuva silmän tai sen apuelinten leesio (katso huomautus sivulta 50) C69.9 Silmä, NOS C69 SILMÄ TAI SEN APUELIMET C69.0 Sidekalvo Conjunctiva C69.1 Sarveiskalvo, NOS Cornea, NOS Limbus corneae C70 KESKUSHERMOSTOKALVOT C69.2 Verkkokalvo Retina C69.3 Silmän suonikalvo Chorioidea C69.4 Sädekehä Bulbus oculi Corpus ciliare Iiris Lens crystallina Mykiö Sclera Silmämuna Silmän kovakalvo Silmänvalkuainen Suonikalvosto Tunica vasculosa bulbi Uvea Värikalvo C69.5 Kyynelrauhanen Canaliculus lacrimalis Ductus nasolacrimalis Glandula lacrimalis Kyynelkanava Kyynelpussi Kyyneltiehyt Saccus lacrimalis C69.6 Silmäkuoppa, NOS Orbita, NOS Orbitan autonominen hermosto Orbitan sidekudos Orbitan ääreishermo 67 C70.0 Aivokalvot Falx cerebelli Falx cerebri Falx, NOS Isoaivosirppi Kallon dura mater Kallon kovakalvo Kallon pehmeä kalvo Kallon pia mater Kallon sisäinen arachnoidea mater Kallon sisäinen lukinkalvo Pikkuaivosirppi Pikkuaivoteltta Tentorium cerebelli C70.1 Selkäydinkalvot Selkäytimen arachnoidea mater Selkäytimen dura mater Selkäytimen kovakalvo Selkäytimen lukinkalvo Selkäytimen pehmeä kalvo Selkäytimen pia mater C70.9 Keskushermostokalvot, NOS Arachnoidea mater, NOS Dura mater, NOS Kovakalvo, NOS Lukinkalvo, NOS Pehmeä kalvo, NOS Pia mater, NOS Topografianumerot (jatkuu) C71 AIVOT C71.0 Isoaivot Basaaliganglio Cerebrum Corpus striatum Cortex cerebri Hypothalamus Insula Iso aivokuori Keskushermoston valkea aine Operculum Pallium Putamen Thalamus Tyvitumake C71.1 Otsalohko Frontaalilohko C71.2 Ohimolohko Hippocampus Temporaalilohko Uncus C71.3 Päälakilohko Parietaalilohko C71.4 Takaraivolohko Oksipitaalilohko C71.5 C71.6 C71.7 Aivorunko Aivosilta Medulla oblongata Neljännen aivokammion choroid plexus Neljäs aivokammio, NOS Oliva Pedunculus cerebri Pons Pyramis medullae oblongatae Ventriculus quartus, NOS Ydinjatke C71.8 Eri alueisiin ulottuva aivojen leesio (katso huomautus sivulta 50) Aivokurkiainen Corpus callosum Tapetum C71.9 Aivot, NOS Cranial fossa, NOS C72 SELKÄYDIN, AIVOHERMOT TAI MUU KESKUSHERMOSTON OSA (ei sisällä: ganglia, sympaattiset ja parasympaattiset hermot, ääreishermot C47) Aivokammio, NOS Aivojen sivukammio, NOS Choroid plexus, NOS Ependyma Ependyymi Kolmannen aivokammion choroid plexus Kolmas aivokammio, NOS Ventriculus lateraliksen choroid plexus Ventriculus lateralis, NOS Ventriculus tertius, NOS Pikkuaivot, NOS Cerebellum Vermis cerebelli 68 C72.0 Selkäydin Conus medullaris Filum terminale Medulla spinalis C72.1 Cauda equina Selkäytimen häntä C72.2 Hajuhermo Nervus olfactorius C72.3 Näköhermo Chiasma opticum Nervus opticus Tractus opticus C72.4 Kuulo-tasapainohermo Nervus vestibulocochlearis Topografianumerot (jatkuu) C72.5 C72.8 C72.9 C75 MUUT UMPIRAUHASET JA SENTAPAISET ELIMET Aivohermo, NOS Nervus abducens Nervus accessorius, NOS Nervus facialis Nervus glossopharyngeus Nervus hypoglossus Nervus oculomotorius Nervus trigeminus Nervus trochlearis Nervus vagus Eri alueisiin ulottuva aivojen ja keskushermoston leesio Huom. Aivojen ja keskushermoston kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C70-C72.5. Hermosto, NOS Epiduralis Keskushermosto Parasellaris C75.0 Lisäkilpirauhanen Glandulae parathyreoideae C75.1 Aivolisäke Aivolisäkekuoppa Fossa hypophysialis Glandula pituitaria Hypophysis Rathken pussi Sella turcica C75.2 Kraniofaryngeaalitiehyt C75.3 Käpyrauhanen Corpus pineale Glandula pinealis C75.4 Karotiskeränen Glomus caroticum C75.5 Aorttakeränen ja muut paragangliot Glomus aorticum Glomus coccygeum Glomus jugulare Paraganglio Zuckerkandlin elin C75.8 Eri alueisiin ulottuva umpirauhasen tai sen kaltaisen elimen leesio (katso huomautus sivulta 50) Useiden umpirauhasten leesio C75.9 Umpirauhanen, NOS Endokriininen rauhanen, NOS C73-C75 KILPIRAUHANEN TAI MUU UMPIRAUHANEN C73 KILPIRAUHANEN C73.9 Kilpirauhanen Thyreoidea C74 LISÄMUNUAINEN C74.0 Lisämunuaiskuori Cortex glandulae suprarenalis C74.1 Lisämunuaisydin Medulla glandulae suprarenalis C74.9 Lisämunuainen, NOS Glandula suprarenalis 69 Topografianumerot (jatkuu) C76 MUU TAI EPÄTARKASTI MÄÄRITETTY SIJAINTIPAIKKA C76.0 C76.1 Pää, kasvot, kaula tai niska, NOS Leukapieli, NOS Nenä, NOS Poski, NOS Solisluun yläpuolen alue, NOS Supraclavikulaarialue, NOS Rintakehä, NOS Axilla, NOS Infraclavikulaarialue, NOS Kainalo, NOS Lapaluun alue, NOS Rintaontelo, NOS Solisluun alapuolen alue, NOS Thorax, NOS C76.2 Vatsa, NOS Abdomen, NOS Intra-abdominalis, NOS Vatsanpeitteet, NOS Vatsaontelo C76.3 Lantio, NOS Fossa ischiorectalis Nivusalue, NOS Pakara, NOS Pelvis, NOS Perineum, NOS Perirectaalialue, NOS Ristiselän alue, NOS C76.4 Yläraaja, NOS Hartia, NOS Kyynärpää, NOS Käsi, NOS Olkapää, NOS Ranne, NOS Sormi, NOS C76.5 Alaraaja, NOS Jalka, NOS Lonkka, NOS Nilkka, NOS Polvi, NOS Varvas, NOS C76.7 Muu epätarkasti määritetty paikka Kylki, NOS Selkä, NOS Vartalo, NOS C76.8 Epätarkasti määritetyn paikan eri alueisiin ulottuva leesio (katso huomautus sivulta 50) C77 IMUSOLMUKKEET C77.0 70 Pään, kasvojen, kaulan ja niskan imusolmukkeet Alaleuan Henkitorven etupuoliset Kielen Korvantaus Korvasylkirauhasen Kurkunpään etupuoliset Leuanalaiset Leuankärjenalaiset Nieluntakaiset Solisluun yläpuoliset Nodi cervicales Nodi lymphatici linguales Nodi lymphatici occipitales Nodi lymphatici parotidei Nodi lymphatici retroauriculares Nodi lymphatici submandibulares Nodi lymphatici submentales Nodi lymphatici supraclaviculares Nodi prelaryngei Nodi pretracheales Nodi retrophanryngeales Nodus mandibularis Topografianumerot (jatkuu) C77.1 C77.2 Rintakehän imusolmukkeet Henkitorven viereiset Keuhkojen Keuhkoportin Keuhkoputkien Kylkiluuvälien Pallean Rintalastan viereiset Välikarsinan Nodi lymphatici bronchopulmonales Nodi lymphatici hilares Nodi lymphatici intercostales Nodi lymphatici mediastinales Nodi lymphatici parasternales Nodi lymphatici paratracheales Nodi lymphatici phrenici Nodi lymphatici pulmonales Nodi lymphatici thoracis Vatsan imusolmukkeet Haiman Mahalaukun Mahanportin Maksan Paksusuolen Para-aortaaliset Pernan Sisusvaltimorungon Suoliliepeen Vatsakalvontakaiset Nodi lymphatici abdominis Nodi lymphatici coeliaci Nodi lymphatici colici Nodi lymphatici gastrici Nodi lymphatici hepatici Nodi lymphatici ileocolici Nodi lymphatici lumbales Nodi lymphatici mesenterici Nodi lymphatici pancreatici Nodi lymphatici periaortici Nodi lymphatici pylorici Nodi lymphatici retroperitoneales Nodi lymphatici splenici C77.3 Kainalon tai yläraajan imusolmukkeet Kyynärtaipeen Olkavarren Solisluun alaiset Nodi lymphatici axillares Nodi lymphatici brachiales Nodi lymphatici cubitales Nodi lymphatici infraclaviculares C77.4 Nivusseudun tai alaraajan imusolmukkeet Nivustaipeen Polvitaipeen Cloquetin imusolmuke Nodi lymphatici inguinales Nodi lymphatici poplitei Rosenmüllerin imusolmuke C77.5 Lantion imusolmukkeet Kohdun viereiset Lonkan Peittyneen aukon kanavassa sijaitsevat Ristiluuvaltimoiden Sydänalan alemmat Nodi lymphatici epigastici inferiores Nodi lymphatici iliaci Nodi lymphatici obturatori Nodi lymphatici parauterini Nodi lymphatici sacrales C77.8 Eri alueiden imusolmukkeet C77.9 Imusolmuke, NOS C80 TUNTEMATON SIJAINTIPAIKKA C80.9 71 Tuntematon sijaintipaikka 5. MERKKI: KASVAINTEN KÄYTTÄYTYMINEN /0 Hyvänlaatuinen /1 Epävarma tai tuntematon käyttäytyminen Borderline Low malignant potential Uncertain malignant potential /2 In situ Intraepiteliaalinen Noninfiltrating Non-invasiivinen /3 Pahanlaatuinen, primaaripaikka /6 Pahanlaatuinen, metastaasi Pahanlaatuinen, sekundaarinen /9 Pahanlaatuinen, epävarmaa, onko primaari- vai sekundaarikasvain 72 6. MERKKI: HISTOLOGINEN ERILAISTUMINEN 1 I aste Hyvin erilaistunut Erilaistunut, NOS 2 II aste Kohtalaisen erilaistunut Kohtalaisen hyvin erilaistunut Keskinkertaisen erilaistunut 3 III aste Huonosti erilaistunut 4 IV aste Erilaistumaton Anaplastinen 9 Erilaistumisastetta ei ole määritelty, tai mainittu tai sitä ei käytetä ___________________________________________________________________________ 6. MERKKI: LYMFOOMIEN JA LEUKEMIOIDEN IMMUNOFENOTYYPIN ILMAISEMINEN 5 T-solu 6 B-solu Pre-B B-esiaste 7 Null solu Non T-non B 8 NK solu Luonnollinen tappajasolu 9 Solutyyppiä ei ole määritelty tai mainittu 73 74 MORFOLOGY 800 NEOPLASMS, NOS 8000/0 8000/1 8000/3 8000/6 8000/9 801-804 EPITHELIAL NEOPLASMS, NOS Neoplasm, benign Tumor, benign Unclassified tumor, benign 8010/0 Epithelial tumor, benign 8010/2 Carcinoma in situ, NOS Intraepithelial carcinoma, NOS 8010/3 Carcinoma, NOS Epithelial tumor, malignant 8010/6 Carcinoma, metastatic, NOS Secondary carcinoma 8010/9 Carcinomatosis Neoplasm, malignant Tumor, malignant, NOS Malignancy Cancer Unclassified tumor, malignant Blastoma, NOS 8011/0 Epithelioma, benign 8011/3 Epithelioma, malignant Epithelioma, NOS 8012/3 Large cell carcinoma, NOS Neoplasm, metastatic Neoplasm, secondary Tumor, metastatic Tumor, secondary Tumor embolus 8013/3 Large cell neuroendocrine carcinoma 8014/3 Large cell carcinoma with rhabdoid phenotype 8015/3 Glassy cell carcinoma 8020/3 Carcinoma, undifferentiated, NOS 8021/3 Carcinoma, anaplastic, NOS Neoplasm, uncertain whether benign or malignant Neoplasm, NOS Tumor, NOS Unclassified tumor, uncertain whether benign or malignant Unclassified tumor, borderline malignancy Neoplasm, malignant, uncertain whether primary or metastatic Unclassified tumor, malignant, uncertain whether primary or metastatic 8001/0 Tumor cells, benign 8022/3 Pleomorphic carcinoma 8001/1 Tumor cells, uncertain whether benign or malignant Tumor cells, NOS 8030/3 Giant cell and spindle cell carcinoma 8031/3 Giant cell carcinoma 8001/3 Tumor cells, malignant 8032/3 Spindle cell carcinoma, NOS 8002/3 Malignant tumor, small cell type 8033/3 Pseudosarcomatous carcinoma Sarcomatoid carcinoma 8003/3 Malignant tumor, giant cell type 8034/3 Polygonal cell carcinoma 8004/3 Malignant tumor, spindle cell type Malignant tumor, fusiform cell type 8035/3 Carcinoma with osteoclast-like giant cells 8005/0 Clear cell tumor, NOS 8040/0 Tumorlet, benign 8005/3 Malignant tumor, clear cell type 8040/1 Tumorlet, NOS 75 Morphology –Numerical (continued) 8041/3 Small cell carcinoma, NOS Reserve cell carcinoma Round cell carcinoma Small cell neuroendocrine carcinoma 8070/3 Squamous cell carcinoma, NOS Epidermoid carcinoma, NOS Squamous carcinoma Squamous cell epithelioma 8042/3 Oat cell carcinoma (C34._) 8070/6 Squamous cell carcinoma, metastatic, NOS 8043/3 Small cell carcinoma, fusiform cell 8071/3 8044/3 Small cell carcinoma, intermediate cell 8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma Squamous cell carcinoma, keratinizing, NOS Squamous cell carcinoma, large cell, keratinizing Epidermoid carcinoma, keratinizing 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS Squamous cell carcinoma, nonkeratinizing, NOS Epidermoid carcinoma, large cell, nonkeratinizing 8073/3 Squamous cell carcinoma, small cell, nonkeratinizing Epidermoid carcinoma, small cell, nonkeratinizing 8074/3 Squamous cell carcinoma, spindle cell Epidermoid carcinoma, spindle cell Squamous cell carcinoma, sarcomatoid 8075/3 Squamous cell carcinoma, adenoid Squamous cell carcinoma, pseudoglandular Squamous cell carcinoma, acantholytic 8076/2 Squamous cell carcinoma in situ with questionable stromal invasion Epidermoid carcinoma in situ with questionable stromal invasion 8076/3 Squamous cell carcinoma, microinvasive 8077/2 Squamous intraepithelial neoplasia, grade III (see Coding Guidelines, page 31) Cervical intraepithelial neoplasia, grade III (C53._) CIN III, NOS (C53._) CIN III with severe dysplasia (C53._) Vaginal intraepithelial neoplasia, grade III (C52._) VAIN III (C52._) Vulvar intraepithelial neoplasia, grade III (C51._) VIN III (C51._) Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) 8046/3 Non-small cell carcinoma (C34._) 805-808 SQUAMOUS CELL NEOPLASMS 8050/0 Papilloma, NOS (except papilloma of bladder M-8120/1) 8050/2 Papillary carcinoma in situ 8050/3 Papillary carcinoma, NOS 8051/0 Verrucous papilloma 8051/3 Verrucous carcinoma, NOS Condylomatous carcinoma Verrucous squamous cell carcinoma Verrucous epidermoid carcinoma Warty carcinoma 8052/0 Squamous cell papilloma, NOS Squamous papilloma Keratotic papilloma 8052/2 Papillary squamous cell carcinoma, non-invasive Papillary squamous cell carcinoma in situ 8052/3 Papillary squamous cell carcinoma Papillary epidermoid carcinoma 8053/0 Squamous cell papilloma, inverted 8060/0 Squamous papillomatosis Papillomatosis, NOS 8070/2 Squamous cell carcinoma in situ, NOS Epidermoid carcinoma in situ, NOS Intraepidermal carcinoma, NOS Intraepithelial squamous cell carcinoma 76 Morphology –Numerical (continued) 8078/3 Squamous cell carcinoma with horn formation 8080/2 Queyrat erythroplasia (C60._) 8081/2 Bowen disease (C44._) Intraepidermal squamous cell carcinoma, Bowen type (C44._) 8082/3 Lymphoepithelial carcinoma Lymphoepithelioma Lymphoepithelioma-like carcinoma Schmincke tumor (C11._) 8095/3 Metatypical carcinoma (C44._) 8096/0 Intraepidermal epithelioma of Jadassohn (C44._) 8097/3 Basal cell carcinoma, nodular (C44._) Basal cell carcinoma, micronodular (C44._) 8098/3 Adenoid basal carcinoma (C53._) 8100/0 Trichoepithelioma (C44._) Brooke tumor (C44._) Epithelioma adenoides cysticum (C44._) 8083/3 Basaloid squamous cell carcinoma 8101/0 Trichofolliculoma (C44._) 8084/3 Squamous cell carcinoma, clear cell type 8102/0 Trichilemmoma (C44._) 8102/3 Trichilemmocarcinoma (C44._) Trichilemmal carcinoma (C44._) 8103/0 Pilar tumor (C44._) Proliferating trichilemmal cyst Proliferating trichilemmal tumor 809-811 BASAL CELL NEOPLASMS 8090/1 Basal cell tumor (C44._) 8090/3 Basal cell carcinoma, NOS (C44._) Basal cell epithelioma (C44._) Rodent ulcer (C44._) Pigmented basal cell carcinoma (C44._) 8110/0 Pilomatrixoma, NOS (C44._) Calcifying epithelioma of Malherbe (C44._) Pilomatricoma, NOS (C44._) 8091/3 Multifocal superficial basal cell carcinoma (C44._) Multicentric basal cell carcinoma (C44._) 8110/3 Pilomatrix carcinoma (C44._) Pilomatrixoma, malignant (C44._) Pilomatricoma, malignant (C44._) Matrical carcinoma (C44._) 8092/3 Infiltrating basal cell carcinoma, NOS (C44._) Infiltrating basal cell carcinoma, non sclerosing (C44._) Infiltrating basal cell carcinoma, sclerosing (C44._) Basal cell carcinoma, morpheic (C44._) Basal cell carcinoma, desmoplastic type (C44._) 8093/3 8094/3 812-813 TRANSITIONAL CELL PAPILLOMAS AND CARCINOMAS Basal cell carcinoma, fibroepithelial (C44._) Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS 8120/0 Transitional cell papilloma, benign Transitional papilloma 8120/1 Urothelial papilloma, NOS Papilloma of bladder (C67._) Transitional cell papilloma, NOS 8120/2 Transitional cell carcinoma in situ Urothelial carcinoma in situ 8120/3 Basosquamous carcinoma (C44._) Mixed basal-squamous cell carcinoma (C44._) 77 Transitional cell carcinoma, NOS Urothelial carcinoma, NOS Transitional carcinoma Morphology –Numerical (continued) 8121/0 8121/1 8121/3 Schneiderian papilloma, NOS (C30.0, C31._) Sinonasal papilloma, NOS (C30.0, C31._) Sinonasal papilloma, exophytic (C30.0, C31._) Sinonasal papilloma, fungiform (C30.0, C31._) Transitional cell papilloma, inverted, benign Transitional papilloma, inverted, benign 8140/6 Adenocarcinoma, metastatic, NOS 8141/3 Scirrhous adenocarcinoma Scirrhous carcinoma Carcinoma with productive fibrosis 8142/3 Linitis plastica (C16._) 8143/3 Superficial spreading adenocarcinoma Transitional cell papilloma, inverted, NOS Transitional papilloma, inverted, NOS Schneiderian papilloma, inverted (C30.0, C31._) Columnar cell papilloma Cylindrical cell papilloma (C30.0, C31._) Oncocytic Schneiderian papilloma (C30.0, C31._) 8144/3 Adenocarcinoma, intestinal type (C16._) Carcinoma, intestinal type (C16._) 8145/3 Carcinoma, diffuse type (C16._) Adenocarcinoma, diffuse type (C16._) 8146/0 Monomorphic adenoma 8147/0 Basal cell adenoma 8147/3 Basal cell adenocarcinoma 8148/2 Glandular intraepithelial neoplasia, grade III Prostatic intraepithelial neoplasia, grade III (C61.9) PIN III (C61.9) 8149/0 Canalicular adenoma 8150/0 Islet cell adenoma (C25._) Islet cell tumor, benign (C25._) Nesidioblastoma (C25._) Islet cell adenomatosis (C25._) 8150/1 Islet cell tumor, NOS (C25._) 8150/3 Islet cell carcinoma (C25._) Islet cell adenocarcinoma (C25._) 8151/0 Insulinoma, NOS (C25._) Beta cell adenoma (C25._) 8151/3 Insulinoma, malignant (C25._) Beta cell tumor, malignant (C25._) 8152/1 Glucagonoma, NOS (C25._) Alpha cell tumor, NOS (C25._) 8152/3 Glucagonoma, malignant (C25._) Alpha cell tumor, malignant (C25._) 8153/1 Gastrinoma, NOS G cell tumor, NOS Gastrin cell tumor 8153/3 Gastrinoma, malignant G cell tumor, malignant Gastrin cell tumor, malignant Schneiderian carcinoma (C30.0, C31._) Cylindrical cell carcinoma (C30.0, C31._) 8122/3 Transitional cell carcinoma, spindle cell Transitional cell carcinoma, sarcomatoid 8123/3 Basaloid carcinoma 8124/3 Cloacogenic carcinoma (C21.2) 8130/1 Papillary transitional cell neoplasm of low malignant potential (C67._) Papillary urothelial neoplasm of low malignant potential (C67._) 8130/2 8130/3 8131/3 Papillary transitional cell carcinoma, non-invasive (C67._) Papillary urothelial carcinoma, noninvasive (C67._) Papillary transitional cell carcinoma (C67._) Papillary urothelial carcinoma (C67._) Transitional cell carcinoma, micropapillary (C67._) 814-838 ADENOMAS AND ADENOCARCINOMAS 8140/0 Adenoma, NOS 8140/1 Atypical adenoma Bronchial adenoma, NOS (C34._) 8140/2 Adenocarcinoma in situ, NOS 8140/3 Adenocarcinoma, NOS 78 Morphology –Numerical (continued) 8154/3 Mixed islet cell and exocrine adenocarcinoma (C25._) Mixed acinar-endocrine carcinoma (C25._) Mixed ductal-endocrine carcinoma (C25._) 8155/1 Vipoma, NOS 8155/3 Vipoma, malignant 8156/1 Somatostatinoma, NOS Somatostatin cell tumor, NOS 8156/3 Somatostatinoma, malignant Somatostatin cell tumor, malignant 8157/1 Enteroglucagonoma, NOS 8157/3 Enteroglucagonoma, malignant 8160/0 Bile duct adenoma (C22.1, C24.0) Cholangioma (C22.1, C24.0) 8160/3 Cholangiocarcinoma (C22.1, C24.0) Bile duct carcinoma (C22.1, C24.0) Bile duct adenocarcinoma (C22.1, C24.0) 8161/0 Bile duct cystadenoma (C22.1, C24.0) 8161/3 Bile duct cystadenocarcinoma (C22.1, C24.0) 8162/3 Klatskin tumor (C22.1, C24.0) 8170/0 Liver cell adenoma (C22.0) Hepatocellular adenoma (C22.0) Hepatoma, benign (C22.0) 8170/3 Hepatocellular carcinoma, NOS (C22.0) Liver cell carcinoma (C22.0) Hepatocarcinoma (C22.0) Hepatoma, malignant (C22.0) Hepatoma, NOS (C22.0) 8171/3 Hepatocellular carcinoma, fibrolamellar (C22.0) 8172/3 Hepatocellular carcinoma, scirrhous (C22.0) Sclerosing hepatic carcinoma (C22.0) 8173/3 Hepatocellular carcinoma, spindle cell variant (C22.0) Hepatocellular carcinoma, sarcomatoid (C22.0) 8174/3 Hepatocellular carcinoma, clear cell type (C22.0) 79 8175/3 Hepatocellular carcinoma, pleomorphic type (C22.0) 8180/3 Combined hepatocellular carcinoma and cholangiocarcinoma (C22.0) Mixed hepatocellular and bile duct carcinoma (C22.0) Hepatocholangiocarcinoma (C22.0) 8190/0 Trabecular adenoma 8190/3 Trabecular adenocarcinoma Trabecular carcinoma 8191/0 Embryonal adenoma 8200/0 Eccrine dermal cylindroma (C44._) Turban tumor (C44.4) Cylindroma of skin (C44._) 8200/3 Adenoid cystic carcinoma Adenocystic carcinoma Cylindroma, NOS (except cylindroma of skin M-8200/0) Adenocarcinoma, cylindroid Bronchial adenoma, cylindroid (C34._) [obs] 8201/2 Cribriform carcinoma in situ (C50._) Ductal carcinoma in situ, cribriform type (C50._) 8201/3 Cribriform carcinoma, NOS Ductal carcinoma, cribriform type (C50._) 8202/0 Microcystic adenoma (C25._) 8204/0 Lactating adenoma (C50._) 8210/0 Adenomatous polyp, NOS Polypoid adenoma 8210/2 Adenocarcinoma in situ in adenomatous polyp Adenocarcinoma in situ in tubular adenoma Carcinoma in situ in adenomatous polyp Adenocarcinoma in situ in polypoid adenoma Adenocarcinoma in situ in a polyp, NOS Carcinoma in situ in a polyp, NOS 8210/3 Adenocarcinoma in adenomatous polyp Adenocarcinoma in tubular adenoma Carcinoma in adenomatous polyp Adenocarcinoma in polypoid adenoma Adenocarcinoma in a polyp, NOS Carcinoma in a polyp, NOS Morphology –Numerical (continued) 8211/0 Tubular adenoma, NOS 8242/1 Enterochromaffin-like cell carcinoid, NOS ECL cell carcinoid, NOS 8211/3 Tubular adenocarcinoma Tubular carcinoma 8242/3 Enterochromaffin-like cell tumor, malignant ECL cell carcinoid, malignant 8212/0 Flat adenoma 8213/0 Serrated adenoma (C18._) Mixed adenomatous and hyperplastic polyp (C18._) 8243/3 Goblet cell carcinoid Mucocarcinoid tumor Mucinous carcinoid 8214/3 Parietal cell carcinoma (C16._) Parietal cell adenocarcinoma (C16._) 8244/3 Composite carcinoid Combined carcinoid and adenocarcinoma Mixed carcinoid-adenocarcinoma 8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts (C21.1) 8245/1 Tubular carcinoid Adenomatous polyposis coli (C18._) Familial polyposis coli (C18._) Adenomatosis, NOS 8245/3 Adenocarcinoid tumor 8246/3 Neuroendocrine carcinoma, NOS 8220/3 Adenocarcinoma in adenomatous polyposis coli (C18._) 8247/3 8221/0 Multiple adenomatous polyps Merkel cell carcinoma (C44._) Merkel cell tumor (C44._) Primary cutaneous neuroendocrine carcinoma (C44._) 8221/3 Adenocarcinoma in multiple adenomatous polyps 8248/1 Apudoma 8249/3 Atypical carcinoid tumor 8230/2 Ductal carcinoma in situ, solid type (C50._) Intraductal carcinoma, solid type 8250/1 Pulmonary adenomatosis (C34._) 8250/3 Bronchiolo-alveolar adenocarcinoma, NOS (C34._) Bronchiolo-alveolar carcinoma, NOS (C34._) Bronchiolar adenocarcinoma (C34._) Bronchiolar carcinoma (C34._) Alveolar cell carcinoma (C34._) 8251/0 Alveolar adenoma (C34._) 8251/3 Alveolar adenocarcinoma (C34._) Alveolar carcinoma 8252/3 Bronchiolo-alveolar carcinoma, nonmucinous (C34._) Bronchiolo-alveolar carcinoma, Clara cell (C34._) Bronchiolo-alveolar carcinoma, type II pneumocyte (C34._) 8253/3 Bronchiolo-alveolar carcinoma, mucinous (C34._) Bronchiolo-alveolar carcinoma, goblet cell type (C34._) 8220/0 8230/3 Solid carcinoma, NOS Solid carcinoma with mucin formation Solid adenocarcinoma with mucin formation 8231/3 Carcinoma simplex 8240/1 Carcinoid tumor of uncertain malignant potential Carcinoid tumor, NOS, of appendix (C18.1) Carcinoid, NOS, of appendix (C18.1) Carcinoid tumor, argentaffin, NOS Argentaffinoma, NOS [obs] 8240/3 8241/3 Carcinoid tumor, NOS (except of appendix M-8240/1) Carcinoid, NOS (except of appendix M-8240/1) Typical carcinoid Bronchial adenoma, carcinoid (C34._) Enterochromaffin cell carcinoid Carcinoid tumor, argentaffin, malignant Argentaffinoma, malignant [obs] EC cell carcinoid Serotonin producing carcinoid 80 Morphology –Numerical (continued) 8254/3 8255/3 Bronchiolo-alveolar carcinoma, mixed mucinous and non-mucinous (C34._) Bronchiolo-alveolar carcinoma, Clara cell and goblet cell type (C34._) Bronchiolo-alveolar carcinoma, type II pneumocyte and goblet cell type (C34._) Bronchiolo-alveolar carcinoma, indeterminate type (C34._) Adenocarcinoma with mixed subtypes Adenocarcinoma combined with other types of carcinoma 8260/0 Papillary adenoma, NOS Glandular papilloma 8260/3 Papillary adenocarcinoma, NOS Papillary carcinoma of thyroid (C73.9) Papillary renal cell carcinoma (C64.9) 8261/0 Villous adenoma, NOS Villous papilloma 8261/2 Adenocarcinoma in situ in villous adenoma 8261/3 Adenocarcinoma in villous adenoma 8262/3 Villous adenocarcinoma 8263/0 Tubulovillous adenoma, NOS Villoglandular adenoma Papillotubular adenoma 8263/2 Adenocarcinoma in situ in tubulovillous adenoma 8263/3 Adenocarcinoma in tubulovillous adenoma Papillotubular adenocarcinoma Tubulopapillary adenocarcinoma 8264/0 Papillomatosis, glandular Biliary papillomatosis (C22.1, C24.0) 8270/0 Chromophobe adenoma (C75.1) 8270/3 Chromophobe carcinoma (C75.1) Chromophobe adenocarcinoma (C75.1) 8271/0 Prolactinoma (C75.1) 8272/0 Pituitary adenoma, NOS (C75.1) 8272/3 Pituitary carcinoma, NOS (C75.1) 8280/0 Acidophil adenoma (C75.1) Eosinophil adenoma (C75.1) 81 8280/3 Acidophil carcinoma (C75.1) Acidophil adenocarcinoma (C75.1) Eosinophil carcinoma (C75.1) Eosinophil adenocarcinoma (C75.1) 8281/0 Mixed acidophil-basophil adenoma (C75.1) 8281/3 Mixed acidophil-basophil carcinoma (C75.1) 8290/0 Oxyphilic adenoma Oncocytic adenoma Oncocytoma Hurthle cell adenoma (C73.9) Hurthle cell tumor (C73.9) Follicular adenoma, oxyphilic cell (C73.9) 8290/3 Oxyphilic adenocarcinoma Oncocytic carcinoma Oncocytic adenocarcinoma Hurthle cell carcinoma (C73.9) Hurthle cell adenocarcinoma (C73.9) Follicular carcinoma, oxyphilic cell (C73.9) 8300/0 Basophil adenoma (C75.1) Mucoid cell adenoma (C75.1) 8300/3 Basophil carcinoma (C75.1) Basophil adenocarcinoma (C75.1) Mucoid cell adenocarcinoma (C75.1) 8310/0 Clear cell adenoma 8310/3 Clear cell adenocarcinoma, NOS Clear cell carcinoma Clear cell adenocarcinoma, mesonephroid 8311/1 Hypernephroid tumor [obs] 8312/3 Renal cell carcinoma, NOS (C64.9) Renal cell adenocarcinoma (C64.9) Grawitz tumor (C64.9) [obs] Hypernephroma (C64.9) [obs] 8313/0 Clear cell adenofibroma (C56.9) Clear cell cystadenofibroma (C56.9) 8313/1 Clear cell adenofibroma of borderline malignancy (C56.9) Clear cell cystadenofibroma of borderline malignancy (C56.9) 8313/3 Clear cell adenocarcinofibroma (C56.9) Clear cell cystadenocarcinofibroma (C56.9) 8314/3 Lipid-rich carcinoma (C50._) 8315/3 Glycogen-rich carcinoma Morphology –Numerical (continued) 8316/3 Cyst-associated renal cell carcinoma (C64.9) 8334/0 Macrofollicular adenoma (C73.9) Colloid adenoma (C73.9) 8317/3 Renal cell carcinoma, chromophobe type (C64.9) Chromophobe cell renal carcinoma (C64.9) 8335/3 Follicular carcinoma, minimally invasive (C73.9) Follicular carcinoma, encapsulated (C73.9) 8318/3 Renal cell carcinoma, sarcomatoid (C64.9) Renal cell carcinoma, spindle cell (C64.9) 8336/0 Hyalinizing trabecular adenoma (C73.9) 8337/3 Insular carcinoma (C73.9) 8319/3 Collecting duct carcinoma (C64.9) Bellini duct carcinoma (C64.9) Renal carcinoma, collecting duct type (C64.9) 8340/3 8320/3 Granular cell carcinoma Granular cell adenocarcinoma Papillary carcinoma, follicular variant (C73.9) Papillary adenocarcinoma, follicular variant (C73.9) Papillary and follicular adenocarcinoma (C73.9) Papillary and follicular carcinoma (C73.9) 8321/0 Chief cell adenoma (C75.0) 8341/3 Papillary microcarcinoma (C73.9) 8322/0 Water-clear cell adenoma (C75.0) 8342/3 Papillary carcinoma, oxyphilic cell (C73.9) 8322/3 Water-clear cell adenocarcinoma (C75.0) Water-clear cell carcinoma (C75.0) 8343/3 Papillary carcinoma, encapsulated (C73.9) 8323/0 Mixed cell adenoma 8344/3 8323/3 Mixed cell adenocarcinoma Papillary carcinoma, columnar cell (C73.9) Papillary carcinoma, tall cell (C73.9) 8324/0 Lipoadenoma Adenolipoma 8345/3 8325/0 Metanephric adenoma (C64.9) Medullary carcinoma with amyloid stroma (C73.9) Parafollicular cell carcinoma (C73.9) C cell carcinoma (C73.9) 8330/0 Follicular adenoma (C73.9) 8346/3 Mixed medullary-follicular carcinoma (C73.9) 8330/1 Atypical follicular adenoma (C73.9) 8347/3 8330/3 Follicular adenocarcinoma, NOS (C73.9) Follicular carcinoma, NOS (C73.9) Mixed medullary-papillary carcinoma (C73.9) 8350/3 8331/3 Follicular adenocarcinoma, well differentiated (C73.9) Follicular carcinoma, well differentiated (C73.9) 8332/3 Follicular adenocarcinoma, trabecular (C73.9) Follicular carcinoma, trabecular (C73.9) Follicular adenocarcinoma, moderately differentiated (C73.9) Follicular carcinoma, moderately differentiated (C73.9) Nonencapsulated sclerosing carcinoma (C73.9) Nonencapsulated sclerosing adenocarcinoma (C73.9) Nonencapsulated sclerosing tumor (C73.9) Papillary carcinoma, diffuse sclerosing (C73.9) 8360/1 Multiple endocrine adenomas Endocrine adenomatosis 8361/0 Juxtaglomerular tumor (C64.9) Reninoma (C64.9) Microfollicular adenoma, NOS (C73.9) Fetal adenoma (C73.9) 8370/0 Adrenal cortical adenoma, NOS (C74.0) Adrenal cortical tumor, benign (C74.0) Adrenal cortical tumor, NOS (C74.0) 8333/0 8333/3 Fetal adenocarcinoma 82 Morphology –Numerical (continued) 8370/3 Adrenal cortical carcinoma (C74.0) Adrenal cortical adenocarcinoma (C74.0) Adrenal cortical tumor, malignant (C74.0) 8371/0 Adrenal cortical adenoma, compact cell (C74.0) 8372/0 Adrenal cortical adenoma, pigmented (C74.0) Black adenoma (C74.0) Pigmented adenoma (C74.0) 8373/0 Adrenal cortical adenoma, clear cell (C74.0) 8374/0 Adrenal cortical adenoma, glomerulosa cell (C74.0) 8375/0 Adrenal cortical adenoma, mixed cell (C74.0) 8380/0 Endometrioid adenoma, NOS Endometrioid cystadenoma, NOS 8380/1 Endometrioid adenoma, borderline malignancy Endometrioid cystadenoma, borderline malignancy Endometrioid tumor of low malignant potential Atypical proliferative endometrioid tumor 8380/3 Endometrioid adenocarcinoma, NOS Endometrioid carcinoma, NOS Endometrioid cystadenocarcinoma 8381/0 Endometrioid adenofibroma, NOS Endometrioid cystadenofibroma, NOS 8381/1 Endometrioid adenofibroma, borderline malignancy Endometrioid cystadenofibroma, borderline malignancy 8381/3 8382/3 839-842 ADNEXAL AND SKIN APPENDAGE NEOPLASMS 8390/0 Skin appendage adenoma (C44._) Skin appendage tumor, benign (C44._) Adnexal tumor, benign (C44._) 8390/3 Skin appendage carcinoma (C44._) Adnexal carcinoma (C44._) 8391/0 Follicular fibroma (C44._) Trichodiscoma (C44._) Fibrofolliculoma (C44._) Perifollicular fibroma (C44._) 8392/0 Syringofibroadenoma (C44._) 8400/0 Sweat gland adenoma (C44._) Sweat gland tumor, benign (C44._) Hidradenoma, NOS (C44._) Syringadenoma, NOS (C44._) 8400/1 Sweat gland tumor, NOS (C44._) 8400/3 Sweat gland adenocarcinoma (C44._) Sweat gland carcinoma (C44._) Sweat gland tumor, malignant (C44._) 8401/0 Apocrine adenoma Apocrine cystadenoma 8401/3 Apocrine adenocarcinoma 8402/0 Nodular hidradenoma (C44._) Eccrine acrospiroma (C44._) Clear cell hidradenoma (C44._) 8402/3 Nodular hidradenoma, malignant (C44._) Hidradenocarcinoma (C44._) 8403/0 Eccrine spiradenoma (C44._) Spiradenoma, NOS (C44._) 8403/3 Malignant eccrine spiradenoma (C44._) 8404/0 Endometrioid adenofibroma, malignant Endometrioid cystadenofibroma, malignant Hidrocystoma (C44._) Eccrine cystadenoma (C44._) 8405/0 Papillary hidradenoma Hidradenoma papilliferum Endometrioid adenocarcinoma, secretory variant 8406/0 Papillary syringadenoma (C44._) Papillary syringocystadenoma (C44._) Syringocystadenoma papilliferum 8407/0 Syringoma, NOS (C44._) 8407/3 Sclerosing sweat duct carcinoma (C44._) Syringomatous carcinoma (C44._) Microcystic adnexal carcinoma (C44._) 8383/3 Endometrioid adenocarcinoma, ciliated cell variant 8384/3 Adenocarcinoma, endocervical type 83 Morphology –Numerical (continued) 8408/0 Eccrine papillary adenoma (C44._) 8443/0 Clear cell cystadenoma (C56.9) 8408/1 Aggressive digital papillary adenoma (C44._) 8444/1 8408/3 Eccrine papillary adenocarcinoma (C44._) Digital papillary adenocarcinoma (C44._) Clear cell cystic tumor of borderline malignancy (C56.9) Atypical proliferating clear cell tumor (C56.9) 8450/0 Papillary cystadenoma, NOS (C56.9) 8409/0 Eccrine poroma (C44._) 8450/3 8409/3 Eccrine poroma, malignant Porocarcinoma (C44._) Papillary cystadenocarcinoma, NOS (C56.9) Papillocystic adenocarcinoma 8410/0 Sebaceous adenoma (C44._) Sebaceous epithelioma (C44._) 8451/1 Papillary cystadenoma, borderline malignancy (C56.9) 8410/3 Sebaceous adenocarcinoma (C44._) Sebaceous carcinoma (C44._) 8452/1 8413/3 Eccrine adenocarcinoma (C44._) Solid pseudopapillary tumor (C25._) Papillary cystic tumor (C25._) Solid and papillary epithelial neoplasm (C25._) Solid and cystic tumor (C25._) 8420/0 Ceruminous adenoma (C44.2) 8452/3 Solid pseudopapillary carcinoma (C25._) 8420/3 Ceruminous adenocarcinoma (C44.2) Ceruminous carcinoma (C44.2) 8453/0 Intraductal papillary-mucinous adenoma (C25._) 8453/1 Intraductal papillary-mucinous tumor with moderate dysplasia (C25._) 8453/2 Intraductal papillary-mucinous carcinoma, non-invasive (C25._) 8453/3 Intraductal papillary-mucinous carcinoma, invasive (C25._) 8454/0 Cystic tumor of atrio-ventricular node (C38.0) 8460/0 Papillary serous cystadenoma, NOS (C56.9) 8460/3 Papillary serous cystadenocarcinoma (C56.9) Papillary serous adenocarcinoma (C56.9) Micropapillary serous carcinoma (C56.9) 8461/0 Serous surface papilloma (C56.9) 8461/3 Serous surface papillary carcinoma (C56.9) Primary serous papillary carcinoma of peritoneum (C48.1) 843 MUCOEPIDERMOID NEOPLASMS 8430/1 Mucoepidermoid tumor [obs] 8430/3 Mucoepidermoid carcinoma 844-849 CYSTIC, MUCINOUS AND SEROUS NEOPLASMS 8440/0 Cystadenoma, NOS Cystoma, NOS 8440/3 Cystadenocarcinoma, NOS 8441/0 Serous cystadenoma, NOS Serous cystoma Serous microcystic adenoma 8441/3 Serous cystadenocarcinoma, NOS (C56.9) Serous adenocarcinoma, NOS Serous carcinoma, NOS 8442/1 Serous cystadenoma, borderline malignancy (C56.9) Serous tumor, NOS, of low malignant potential (C56.9) Atypical proliferating serous tumor (C56.9) 84 Morphology –Numerical (continued) 8462/1 Serous papillary cystic tumor of borderline malignancy (C56.9) Papillary serous cystadenoma, borderline malignancy (C56.9) Papillary serous tumor of low malignant potential (C56.9) Atypical proliferative papillary serous tumor (C56.9) 8463/1 Serous surface papillary tumor of borderline malignancy (C56.9) 8470/0 Mucinous cystadenoma, NOS (C56.9) Mucinous cystoma (C56.9) Pseudomucinous cystadenoma, NOS (C56.9) 8480/3 Mucinous adenocarcinoma Mucinous carcinoma Colloid adenocarcinoma Colloid carcinoma Gelatinous adenocarcinoma [obs] Gelatinous carcinoma [obs] Mucoid adenocarcinoma Mucoid carcinoma Mucous adenocarcinoma Mucous carcinoma Pseudomyxoma peritonei with unknown primary site (C80.9) 8480/6 Pseudomyxoma peritonei 8481/3 Mucin-producing adenocarcinoma Mucin-producing carcinoma Mucin-secreting adenocarcinoma Mucin-secreting carcinoma 8470/1 Mucinous cystic tumor with moderate dysplasia (C25._) 8470/2 Mucinous cystadenocarcinoma, non- invasive (C25._) 8482/3 Mucinous adenocarcinoma, endocervical ..type 8470/3 Mucinous cystadenocarcinoma, NOS (C56.9) Pseudomucinous adenocarcinoma (C56.9) Pseudomucinous cystadenocarcinoma, NOS (C56.9) 8490/3 Signet ring cell carcinoma Signet ring cell adenocarcinoma 8490/6 Metastatic signet ring cell carcinoma Krukenberg tumor 8471/0 Papillary mucinous cystadenoma, NOS (C56.9) Papillary pseudomucinous cystadenoma, NOS (C56.9) 8471/3 Papillary mucinous cystadenocarcinoma (C56.9) Papillary pseudomucinous cystadenocarcinoma (C56.9) 8472/1 Mucinous cystic tumor of borderline malignancy (C56.9) Mucinous cystadenoma, borderline malignancy (C56.9) Pseudomucinous cystadenoma, borderline malignancy (C56.9) Mucinous tumor, NOS, of low malignant potential (C56.9) Atypical proliferative mucinous tumor (C56.9) 8473/1 8480/0 850-854 DUCTAL AND LOBULAR NEOPLASMS Papillary mucinous cystadenoma, borderline malignancy (C56.9) Papillary pseudomucinous cystadenoma, borderline malignancy (C56.9) Papillary mucinous tumor of low malignant potential (C56.9) Mucinous adenoma 85 8500/2 Intraductal carcinoma, noninfiltrating, NOS Intraductal adenocarcinoma, noninfiltrating, NOS Intraductal carcinoma, NOS Ductal carcinoma in situ, NOS (C50._) DCIS, NOS (C50._) Ductal intraepithelial neoplasia 3 (C50._) DIN 3 (C50._) 8500/3 Infiltrating duct carcinoma, NOS (C50._) Infiltrating duct adenocarcinoma (C50._) Duct adenocarcinoma, NOS Duct carcinoma, NOS Duct cell carcinoma Ductal carcinoma, NOS 8501/2 Comedocarcinoma, noninfiltrating (C50._) Ductal carcinoma in situ, comedo type (C50._) DCIS, comedo type (C50._) 8501/3 Comedocarcinoma, NOS (C50._) Morphology –Numerical (continued) 8502/3 Secretory carcinoma of breast (C50._) Juvenile carcinoma of breast (C50._) 8503/0 Intraductal papilloma Duct adenoma, NOS Ductal papilloma 8503/2 Noninfiltrating intraductal papillary adenocarcinoma (C50._) Noninfiltrating intraductal papillary carcinoma (C50._) Intraductal papillary adenocarcinoma, NOS (C50._) Intraductal papillary carcinoma, NOS (C50._) Ductal carcinoma in situ, papillary (C50._) DCIS, papillary (C50._) 8503/3 Intraductal papillary adenocarcinoma with invasion (C50._) Infiltrating papillary adenocarcinoma Infiltrating and papillary adenocarcinoma 8504/0 Intracystic papillary adenoma Intracystic papilloma 8504/2 Noninfiltrating intracystic carcinoma 8504/3 Intracystic carcinoma, NOS Intracystic papillary adenocarcinoma 8505/0 Intraductal papillomatosis, NOS Diffuse intraductal papillomatosis 8506/0 Adenoma of nipple (C50.0) Subareolar duct papillomatosis (C50.0) 8507/2 Intraductal micropapillary carcinoma (C50._) Ductal carcinoma in situ, micropapillary (C50._) Intraductal carcinoma, clinging (C50._) 8520/2 Lobular carcinoma in situ, NOS (C50._) Lobular carcinoma, noninfiltrating (C50._) LCIS, NOS (C50._) 8520/3 Lobular carcinoma, NOS (C50._) Lobular adenocarcinoma (C50._) Infiltrating lobular carcinoma, NOS (C50._) 8521/3 Infiltrating ductular carcinoma (C50._) 8522/2 Intraductal carcinoma and lobular carcinoma in situ (C50._) 8522/3 Infiltrating duct and lobular carcinoma (C50._) Lobular and ductal carcinoma (C50._) Infiltrating duct and lobular carcinoma in situ (C50._) Intraductal and lobular carcinoma (C50._) Infiltrating lobular carcinoma and ductal carcinoma in situ (C50._) 8523/3 Infiltrating duct mixed with other types of carcinoma (C50._) Infiltrating duct and cribriform carcinoma (C50._) Infiltrating duct and mucinous carcinoma (C50._) Infiltrating duct and tubular carcinoma (C50._) Infiltrating duct and colloid carcinoma (C50._) 8524/3 Infiltrating lobular mixed with other types of carcinoma (C50._) 8525/3 Polymorphous low grade adenocarcinoma Terminal duct adenocarcinoma 8530/3 Inflammatory carcinoma (C50._) Inflammatory adenocarcinoma (C50._) 8540/3 Paget disease, mammary (C50._) Paget disease of breast (C50._) 8508/3 Cystic hypersecretory carcinoma (C50._) 8510/3 Medullary carcinoma, NOS Medullary adenocarcinoma 8541/3 Paget disease and infiltrating duct carcinoma of breast (C50._) 8512/3 Medullary carcinoma with lymphoid stroma 8542/3 Paget disease, extramammary (except Paget disease of bone) 8513/3 Atypical medullary carcinoma (C50._) 8543/3 Paget disease and intraductal carcinoma of breast (C50._) 8514/3 Duct carcinoma, desmoplastic type 86 Morphology –Numerical (continued) 855 ACINAR CELL NEOPLASMS 8550/0 Acinar cell adenoma Acinar adenoma Acinic cell adenoma 8550/1 Acinar cell tumor [obs] Acinic cell tumor [obs] 8550/3 Acinar cell carcinoma Acinic cell adenocarcinoma Acinar adenocarcinoma Acinar carcinoma 8575/3 Metaplastic carcinoma, NOS 8576/3 Hepatoid adenocarcinoma Hepatoid carcinoma 858 THYMIC EPITHELIAL NEOPLASMS 8551/3 Acinar cell cystadenocarcinoma 8580/0 Thymoma, benign (C37.9) 8580/1 Thymoma, NOS (C37.9) 8580/3 Thymoma, malignant, NOS (C37.9) 8581/1 Thymoma, type A, NOS (C37.9) Thymoma, spindle cell, NOS (C37.9) Thymoma, medullary, NOS (C37.9) 8581/3 Thymoma, type A, malignant (C37.9) Thymoma, spindle cell, malignant (C37.9) Thymoma, medullary, malignant (C37.9) 8582/1 Thymoma, type AB, NOS (C37.9) Thymoma, mixed type, NOS (C37.9) 8582/3 Thymoma, type AB, malignant (C37.9) Thymoma, mixed type, malignant (C37.9) 8583/1 Thymoma, type B1, NOS (C37.9) Thymoma, lymphocyte-rich, NOS (C37.9) Thymoma, lymphocytic, NOS (C37.9) Thymoma, predominantly cortical, NOS (C37.9) Thymoma, organoid, NOS (C37.9) 8583/3 Thymoma, type B1, malignant (C37.9) Thymoma, lymphocyte-rich, malignant (C37.9) Thymoma, lymphocytic, malignant (C37.9) Thymoma, predominantly cortical, malignant (C37.9) Thymoma, organoid, malignant (C37.9) 8584/1 Thymoma, type B2, NOS (C37.9) Thymoma, cortical, NOS (C37.9) 8584/3 Thymoma, type B2, malignant (C37.9) Thymoma, cortical, malignant (C37.9) 8585/1 Thymoma, type B3, NOS (C37.9) Thymoma, epithelial, NOS (C37.9) Thymoma, atypical, NOS (C37.9) 856-857 COMPLEX EPITHELIAL NEOPLASMS 8560/0 Mixed squamous cell and glandular papilloma 8560/3 Adenosquamous carcinoma Mixed adenocarcinoma and squamous cell carcinoma Mixed adenocarcinoma and epidermoid carcinoma 8561/0 Adenolymphoma (C07._, C08._) Papillary cystadenoma lymphomatosum (C07._, C08._) Warthin tumor (C07._, C08._) 8562/3 Epithelial-myoepithelial carcinoma 8570/3 Adenocarcinoma with squamous metaplasia Adenoacanthoma 8571/3 Adenocarcinoma with cartilaginous and osseous metaplasia Adenocarcinoma with cartilaginous metaplasia Adenocarcinoma with osseous metaplasia 8572/3 Adenocarcinoma with spindle cell metaplasia 8573/3 Adenocarcinoma with apocrine metaplasia Carcinoma with apocrine metaplasia 8574/3 Adenocarcinoma with neuroendocrine differentiation Carcinoma with neuroendocrine differentiation 87 Morphology –Numerical (continued) 8585/3 Thymoma, type B3, malignant (C37.9) Thymoma, epithelial, malignant (C37.9) Thymoma, atypical, malignant (C37.9) Well differentiated thymic carcinoma (C37.9) 8620/3 Granulosa cell tumor, malignant (C56.9) Granulosa cell carcinoma (C56.9) Granulosa cell tumor, sarcomatoid (C56.9) 8621/1 Granulosa cell-theca cell tumor (C56.9) Theca cell-granulosa cell tumor (C56.9) Thymic carcinoma, NOS (C37.9) Thymoma, type C (C37.9) 8622/1 Granulosa cell tumor, juvenile (C56.9) 8587/0 Ectopic hamartomatous thymoma 8623/1 Sex cord tumor with annular tubules (C56.9) 8588/3 Spindle epithelial tumor with thymus-like element Spindle epithelial tumor with thymuslike differentiation SETTLE 8630/0 Androblastoma, benign Arrhenoblastoma, benign 8630/1 Androblastoma, NOS Arrhenoblastoma, NOS 8630/3 Androblastoma, malignant Arrhenoblastoma, malignant 8631/0 Sertoli-Leydig cell tumor, well differentiated 8631/1 Sertoli-Leydig cell tumor of intermediate differentiation Sertoli-Leydig cell tumor, NOS 8631/3 Sertoli-Leydig cell tumor, poorly differentiated Sertoli-Leydig cell tumor, sarcomatoid 8632/1 Gynandroblastoma (C56.9) 8633/1 Sertoli-Leydig cell tumor, retiform 8634/1 Sertoli-Leydig cell tumor, intermediate differentiation, with heterologous elements Sertoli-Leydig cell tumor, retiform, with heterologous elements 8634/3 Sertoli-Leydig cell tumor, poorly differentiated, with heterologous elements 8640/1 Sertoli cell tumor, NOS Pick tubular adenoma Sertoli cell adenoma Tubular androblastoma, NOS Testicular adenoma 8640/3 Sertoli cell carcinoma (C62._) 8586/3 8589/3 Carcinoma showing thymus-like element Carcinoma showing thymus-like differentiation CASTLE 859-867 SPECIALIZED GONADAL NEOPLASMS 8590/1 Sex cord-gonadal stromal tumor, NOS Gonadal stromal tumor, NOS Testicular stromal tumor (C62._) Ovarian stromal tumor (C56.9) Sex cord tumor, NOS 8591/1 Sex cord-gonadal stromal tumor, incompletely differentiated 8592/1 Sex cord-gonadal stromal tumor, mixed forms 8593/1 Stromal tumor with minor sex cord elements (C56.9) 8600/0 Thecoma, NOS (C56.9) Theca cell tumor (C56.9) 8600/3 Thecoma, malignant (C56.9) 8601/0 Thecoma, luteinized (C56.9) 8602/0 Sclerosing stromal tumor (C56.9) 8610/0 Luteoma, NOS (C56.9) Luteinoma (C56.9) 8620/1 Granulosa cell tumor, adult type (C56.9) Granulosa cell tumor, NOS (C56.9) 88 Morphology –Numerical (continued) 8641/0 Sertoli cell tumor with lipid storage Folliculome lipidique (C56.9) Tubular androblastoma with lipid storage (C56.9) Lipid-rich Sertoli cell tumor (C56.9) 8642/1 Large cell calcifying Sertoli cell tumor 8650/0 Leydig cell tumor, benign (C62._) Interstitial cell tumor, benign 8650/1 Leydig cell tumor, NOS (C62._) Interstitial cell tumor, NOS 8650/3 Leydig cell tumor, malignant (C62._) Interstitial cell tumor, malignant 8660/0 Hilus cell tumor (C56.9) Hilar cell tumor (C56.9) 8670/0 Lipid cell tumor of ovary (C56.9) Lipoid cell tumor of ovary (C56.9) Steroid cell tumor, NOS Masculinovoblastoma (C56.9) 8670/3 Steroid cell tumor, malignant 8671/0 Adrenal rest tumor 8693/1 Extra-adrenal paraganglioma, NOS Nonchromaffin paraganglioma, NOS Chemodectoma 8693/3 Extra-adrenal paraganglioma, malignant Nonchromaffin paraganglioma, malignant 8700/0 Pheochromocytoma, NOS (C74.1) Adrenal medullary paraganglioma (C74.1) Chromaffin paraganglioma Chromaffin tumor Chromaffinoma 8700/3 Pheochromocytoma, malignant (C74.1) Adrenal medullary paraganglioma, malignant (C74.1) Pheochromoblastoma (C74.1) 8710/3 Glomangiosarcoma Glomoid sarcoma 8711/0 Glomus tumor, NOS 8711/3 Glomus tumor, malignant 8712/0 Glomangioma 8713/0 Glomangiomyoma 868-871 PARAGANGLIOMAS AND GLOMUS TUMORS 8680/0 Paraganglioma, benign 8680/1 Paraganglioma, NOS 8680/3 Paraganglioma, malignant 8681/1 Sympathetic paraganglioma 8682/1 Parasympathetic paraganglioma 8683/0 Gangliocytic paraganglioma (C17.0) 8690/1 Glomus jugulare tumor, NOS (C75.5) Jugular paraganglioma (C75.5) Jugulotympanic paraganglioma (C75.5) 8691/1 8692/1 872-879 NEVI AND MELANOMAS Aortic body tumor (C75.5) Aortic body paraganglioma (C75.5) Aorticopulmonary paraganglioma (C75.5) Carotid body tumor (C75.4) Carotid body paraganglioma (C75.4) 89 8720/0 Pigmented nevus, NOS (C44._) Nevus, NOS (C44._) Melanocytic nevus (C44._) Hairy nevus (C44._) 8720/2 Melanoma in situ 8720/3 Malignant melanoma, NOS (except juvenile melanoma M-8770/0) Melanoma, NOS 8721/3 Nodular melanoma (C44._) 8722/0 Balloon cell nevus (C44._) 8722/3 Balloon cell melanoma (C44._) 8723/0 Halo nevus (C44._) Regressing nevus (C44._) 8723/3 Malignant melanoma, regressing (C44._) 8725/0 Neuronevus (C44._) Morphology –Numerical (continued) 8726/0 Magnocellular nevus (C69.4) Melanocytoma, eyeball (C69.4) Melanocytoma, NOS 8727/0 Dysplastic nevus (C44._) 8728/0 Diffuse melanocytosis (C70.9) 8728/1 Meningeal melanocytoma (C70.9) 8728/3 Meningeal melanomatosis (C70.9) 8730/0 Nonpigmented nevus (C44._) Achromic nevus (C44._) 8730/3 8740/0 8761/3 Malignant melanoma in giant pigmented nevus (C44._) Malignant melanoma in congenital melanocytic nevus (C44._) 8762/1 Proliferative dermal lesion in congenital nevus (C44._) 8770/0 Epithelioid and spindle cell nevus (C44._) Juvenile nevus (C44._) Juvenile melanoma (C44._) Spitz nevus (C44._) Pigmented spindle cell nevus of Reed (C44._) Amelanotic melanoma (C44._) 8770/3 Mixed epithelioid and spindle cell melanoma Junctional nevus, NOS (C44._) Junction nevus (C44._) Intraepidermal nevus (C44._) 8771/0 Epithelioid cell nevus (C44._) 8771/3 Epithelioid cell melanoma Malignant melanoma in junctional nevus (C44._) 8772/0 Spindle cell nevus, NOS (C44._) 8741/2 Precancerous melanosis, NOS (C44._) 8772/3 Spindle cell melanoma, NOS 8741/3 Malignant melanoma in precancerous melanosis (C44._) 8773/3 Spindle cell melanoma, type A (C69._) 8774/3 Spindle cell melanoma, type B (C69._) 8742/2 Lentigo maligna (C44._) Hutchinson melanotic freckle, NOS (C44._) 8780/0 Blue nevus, NOS (C44._) Jadassohn blue nevus (C44._) 8780/3 Blue nevus, malignant (C44._) 8790/0 Cellular blue nevus (C44._) 8740/3 8742/3 Lentigo maligna melanoma (C44._) Malignant melanoma in Hutchinson melanotic freckle (C44._) 8743/3 Superficial spreading melanoma (C44._) 8744/3 Acral lentiginous melanoma, malignant (C44._) 8745/3 880 SOFT TISSUE TUMORS AND SARCOMAS, NOS Desmoplastic melanoma, malignant (C44._) Neurotropic melanoma, malignant (C44._) Desmoplastic melanoma, amelanotic (C44._) 8746/3 Mucosal lentiginous melanoma 8750/0 Intradermal nevus (C44._) Dermal nevus (C44._) 8760/0 Compound nevus (C44._) Dermal and epidermal nevus (C44._) 8761/0 Small congenital nevus (C44._) 8761/1 Giant pigmented nevus, NOS (C44._) Intermediate and giant congenital nevus (C44._) 90 8800/0 Soft tissue tumor, benign 8800/3 Sarcoma, NOS Soft tissue sarcoma Soft tissue tumor, malignant Mesenchymal tumor, malignant 8800/9 Sarcomatosis, NOS 8801/3 Spindle cell sarcoma 8802/3 Giant cell sarcoma (except of bone M-9250/3) Pleomorphic cell sarcoma 8803/3 Small cell sarcoma Round cell sarcoma Morphology –Numerical (continued) 8804/3 Epithelioid sarcoma Epithelioid cell sarcoma 8805/3 Undifferentiated sarcoma 8806/3 Desmoplastic small round cell tumor 8825/0 Myofibroblastoma 8825/1 Myofibroblastic tumor, NOS Inflammatory myofibroblastic tumor 8826/0 Angiomyofibroblastoma 8827/1 Myofibroblastic tumor, peribronchial (C34._) Congenital peribronchial myofibroblastic tumor (C34._) 8830/0 Benign fibrous histiocytoma Fibrous histiocytoma, NOS Fibroxanthoma, NOS Xanthofibroma 8830/1 Atypical fibrous histiocytoma Atypical fibroxanthoma 8830/3 Malignant fibrous histiocytoma Fibroxanthoma, malignant 8831/0 Histiocytoma, NOS Deep histiocytoma Juvenile histiocytoma Reticulohistiocytoma 8832/0 Dermatofibroma, NOS (C44._) Sclerosing hemangioma (C44._) Cutaneous histiocytoma, NOS (C44._) Subepidermal nodular fibrosis (C44._) Dermatofibroma lenticulare (C44._) 8832/3 Dermatofibrosarcoma, NOS (C44._) Dermatofibrosarcoma protuberans, NOS (C44._) 8833/3 Pigmented dermatofibrosarcoma protuberans (C44._) Bednar tumor (C44._) 8834/1 Giant cell fibroblastoma 8835/1 Plexiform fibrohistiocytic tumor 8836/1 Angiomatoid fibrous histiocytoma 881-883 FIBROMATOUS NEOPLASMS 8810/0 Fibroma, NOS 8810/1 Cellular fibroma (C56.9) 8810/3 Fibrosarcoma, NOS 8811/0 Fibromyxoma Myxoid fibroma Myxofibroma, NOS 8811/3 Fibromyxosarcoma 8812/0 Periosteal fibroma (C40._, C41._) 8812/3 Periosteal fibrosarcoma (C40._, C41._) Periosteal sarcoma, NOS (C40._, C41._) 8813/0 Fascial fibroma 8813/3 Fascial fibrosarcoma 8814/3 Infantile fibrosarcoma Congenital fibrosarcoma 8815/0 Solitary fibrous tumor Localized fibrous tumor 8815/3 Solitary fibrous tumor, malignant 8820/0 Elastofibroma 8821/1 Aggressive fibromatosis Extra-abdominal desmoid Desmoid, NOS Invasive fibroma 8822/1 Abdominal fibromatosis Abdominal desmoid Mesenteric fibromatosis (C48.1) Retroperitoneal fibromatosis (C48.0) 884 MYXOMATOUS NEOPLASMS 8823/0 Desmoplastic fibroma 8840/0 Myxoma, NOS 8824/0 Myofibroma 8840/3 Myxosarcoma 8824/1 Myofibromatosis Congenital generalized fibromatosis Infantile myofibromatosis 91 Morphology –Numerical (continued) 8841/1 Angiomyxoma Aggressive angiomyxoma 8842/0 Ossifying fibromyxoid tumor 8880/0 Hibernoma Fetal fat cell lipoma Brown fat tumor 8881/0 Lipoblastomatosis Fetal lipoma, NOS Fetal lipomatosis Lipoblastoma 885-888 LIPOMATOUS NEOPLASMS 8850/0 Lipoma, NOS 8850/1 Atypical lipoma Superficial well differentiated liposarcoma Well differentiated liposarcoma of superficial soft tissue 8850/3 Liposarcoma, NOS Fibroliposarcoma 8851/0 Fibrolipoma 8851/3 889-892 MYOMATOUS NEOPLASMS Liposarcoma, well differentiated Liposarcoma, differentiated Lipoma-like liposarcoma Sclerosing liposarcoma Inflammatory liposarcoma 8852/0 Fibromyxolipoma Myxolipoma 8852/3 Myxoid liposarcoma Myxoliposarcoma 8853/3 Round cell liposarcoma 8854/0 Pleomorphic lipoma 8854/3 Pleomorphic liposarcoma 8855/3 Mixed liposarcoma 8856/0 Intramuscular lipoma Infiltrating lipoma Infiltrating angiolipoma 8857/0 Spindle cell lipoma 8857/3 Fibroblastic liposarcoma 8858/3 Dedifferentiated liposarcoma 8860/0 Angiomyolipoma 8861/0 Angiolipoma, NOS 8862/0 Chondroid lipoma 8870/0 Myelolipoma 92 8890/0 Leiomyoma, NOS Fibroid uterus (C55.9) Fibromyoma Leiomyofibroma Plexiform leiomyoma Lipoleiomyoma 8890/1 Leiomyomatosis, NOS Intravascular leiomyomatosis 8890/3 Leiomyosarcoma, NOS 8891/0 Epithelioid leiomyoma Leiomyoblastoma 8891/3 Epithelioid leiomyosarcoma 8892/0 Cellular leiomyoma 8893/0 Bizarre leiomyoma Symplastic leiomyoma Atypical leiomyoma Pleomorphic leiomyoma 8894/0 Angiomyoma Vascular leiomyoma Angioleiomyoma 8894/3 Angiomyosarcoma 8895/0 Myoma 8895/3 Myosarcoma 8896/3 Myxoid leiomyosarcoma 8897/1 Smooth muscle tumor of uncertain malignant potential Smooth muscle tumor, NOS 8898/1 Metastasizing leiomyoma 8900/0 Rhabdomyoma, NOS 8900/3 Rhabdomyosarcoma, NOS Rhabdosarcoma Morphology –Numerical (continued) 8901/3 8902/3 Pleomorphic rhabdomyosarcoma, adult type Pleomorphic rhabdomyosarcoma, NOS Mixed type rhabdomyosarcoma Mixed embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma 8935/3 Stromal sarcoma, NOS 8936/0 Gastrointestinal stromal tumor, benign GIST, benign 8936/1 Gastrointestinal stromal tumor, NOS GIST, NOS Gastrointestinal stromal tumor, uncertain malignant potential Gastrointestinal autonomic nerve tumor GANT Gastrointestinal pacemaker cell tumor 8903/0 Fetal rhabdomyoma 8904/0 Adult rhabdomyoma Glycogenic rhabdomyoma 8905/0 Genital rhabdomyoma (C51._, C52.9) 8936/3 8910/3 Embryonal rhabdomyosarcoma, NOS Embryonal rhabdomyosarcoma, pleomorphic Sarcoma botryoides Botryoid sarcoma Gastrointestinal stromal sarcoma Gastrointestinal stromal tumor, malignant GIST, malignant 8940/0 Pleomorphic adenoma Mixed tumor, NOS Mixed tumor, salivary gland type, NOS (C07._, C08._) Chondroid syringoma (C44._) 8940/3 Mixed tumor, malignant, NOS Mixed tumor, salivary gland type, malignant (C07._, C08._) Malignant chondroid syringoma (C44._) 8941/3 Carcinoma in pleomorphic adenoma (C07._, C08._) 8950/3 Mullerian mixed tumor (C54._) 8912/3 Spindle cell rhabdomyosarcoma 8920/3 Alveolar rhabdomyosarcoma 8921/3 Rhabdomyosarcoma with ganglionic differentiation Ectomesenchymoma 893-899 COMPLEX MIXED AND STROMAL NEOPLASMS 8930/0 Endometrial stromal nodule (C54.1) 8951/3 Mesodermal mixed tumor 8930/3 Endometrial stromal sarcoma, NOS (C54.1) Endometrial sarcoma, NOS (C54.1) Endometrial stromal sarcoma, high grade (C54.1) 8959/0 Benign cystic nephroma (C64.9) 8959/1 Cystic partially differentiated nephroblastoma (C64.9) 8959/3 Malignant cystic nephroma (C64.9) Malignant multilocular cystic nephroma (C64.9) 8960/1 Mesoblastic nephroma 8960/3 Nephroblastoma, NOS (C64.9) Wilms tumor (C64.9) Nephroma, NOS (C64.9) 8963/3 Malignant rhabdoid tumor Rhabdoid sarcoma Rhabdoid tumor, NOS 8964/3 Clear cell sarcoma of kidney (C64.9) 8965/0 Nephrogenic adenofibroma (C64.9) 8931/3 Endometrial stromal sarcoma, low grade (C54.1) Endolymphatic stromal myosis (C54.1) Endometrial stromatosis (C54.1) Stromal endometriosis (C54.1) Stromal myosis, NOS (C54.1) 8932/0 Adenomyoma Atypical polypoid adenomyoma 8933/3 Adenosarcoma 8934/3 Carcinofibroma 8935/0 Stromal tumor, benign 8935/1 Stromal tumor, NOS 93 Morphology –Numerical (continued) 8966/0 Renomedullary interstitial cell tumor (C64.9) Renomedullary fibroma (C64.9) 9013/0 Adenofibroma, NOS Cystadenofibroma, NOS Papillary adenofibroma 8967/0 Ossifying renal tumor (C64.9) 9014/0 Serous adenofibroma, NOS Serous cystadenofibroma, NOS 8970/3 Hepatoblastoma (C22.0) Embryonal hepatoma (C22.0) 9014/1 Serous adenofibroma of borderline malignancy Serous cystadenofibroma of borderline malignancy 9014/3 Serous adenocarcinofibroma Malignant serous adenofibroma Serous cystadenocarcinofibroma Malignant serous cystadenofibroma 9015/0 Mucinous adenofibroma, NOS Mucinous cystadenofibroma, NOS 9015/1 Mucinous adenofibroma of borderline malignancy Mucinous cystadenofibroma of borderline malignancy 9015/3 Mucinous adenocarcinofibroma Malignant mucinous adenofibroma Mucinous cystadenocarcinofibroma Malignant mucinous cystadenofibroma 9016/0 Giant fibroadenoma (C50._) 9020/0 Phyllodes tumor, benign (C50._) Cystosarcoma phyllodes, benign (C50._) [obs] 9020/1 Phyllodes tumor, borderline (C50._) Cystosarcoma phyllodes, NOS (C50._) Phyllodes tumor, NOS (C50._) 9020/3 Phyllodes tumor, malignant (C50._) Cystosarcoma phyllodes, malignant (C50._) 9030/0 Juvenile fibroadenoma (C50._) 8971/3 Pancreatoblastoma (C25._) 8972/3 Pulmonary blastoma (C34._) Pneumoblastoma (C34._) 8973/3 Pleuropulmonary blastoma 8974/1 Sialoblastoma 8980/3 Carcinosarcoma, NOS 8981/3 Carcinosarcoma, embryonal 8982/0 Myoepithelioma Myoepithelial tumor Myoepithelial adenoma 8982/3 Malignant myoepithelioma Myoepithelial carcinoma 8983/0 Adenomyoepithelioma (C50._) 8990/0 Mesenchymoma, benign 8990/1 Mesenchymoma, NOS Mixed mesenchymal tumor 8990/3 Mesenchymoma, malignant Mixed mesenchymal sarcoma 8991/3 Embryonal sarcoma 900-903 FIBROEPITHELIAL NEOPLASMS 9000/0 Brenner tumor, NOS (C56.9) 9000/1 Brenner tumor, borderline malignancy (C56.9) Brenner tumor, proliferating (C56.9) 9000/3 Brenner tumor, malignant (C56.9) 9010/0 Fibroadenoma, NOS (C50._) 9011/0 Intracanalicular fibroadenoma (C50._) 9012/0 Pericanalicular fibroadenoma (C50._) 904 SYNOVIAL-LIKE NEOPLASMS 94 9040/0 Synovioma, benign 9040/3 Synovial sarcoma, NOS Synovioma, NOS Synovioma, malignant 9041/3 Synovial sarcoma, spindle cell Synovial sarcoma, monophasic fibrous Morphology –Numerical (continued) 9042/3 Synovial sarcoma, epithelioid cell 9043/3 Synovial sarcoma, biphasic 9044/3 Clear cell sarcoma, NOS (except of kidney M-8964/3) Clear cell sarcoma, of tendons and aponeuroses (C49._) Melanoma, malignant, of soft parts (C49._) 9063/3 Spermatocytic seminoma (C62._) Spermatocytoma (C62._) 9064/2 Intratubular malignant germ cells (C62._) Intratubular germ cell neoplasia (C62._) 9064/3 Germinoma Germ cell tumor, NOS 9065/3 Germ cell tumor, nonseminomatous (C62._) 9070/3 Embryonal carcinoma, NOS Embryonal adenocarcinoma 9071/3 Yolk sac tumor Endodermal sinus tumor Polyvesicular vitelline tumor Orchioblastoma (C62._) Embryonal carcinoma, infantile Hepatoid yolk sac tumor 9072/3 Polyembryoma Embryonal carcinoma, polyembryonal type 9073/1 Gonadoblastoma Gonocytoma 9080/0 Teratoma, benign Adult cystic teratoma Adult teratoma, NOS Cystic teratoma, NOS Teratoma, differentiated Mature teratoma 905 MESOTHELIAL NEOPLASMS 9050/0 Mesothelioma, benign 9050/3 Mesothelioma, malignant Mesothelioma, NOS 9051/0 Fibrous mesothelioma, benign 9051/3 Fibrous mesothelioma, malignant Fibrous mesothelioma, NOS Spindled mesothelioma Sarcomatoid mesothelioma Desmoplastic mesothelioma 9052/0 Epithelioid mesothelioma, benign Well differentiated papillary mesothelioma, benign Mesothelial papilloma 9052/3 Epithelioid mesothelioma, malignant Epithelioid mesothelioma, NOS 9053/3 Mesothelioma, biphasic, malignant Mesothelioma, biphasic, NOS 9080/1 Teratoma, NOS Solid teratoma 9054/0 Adenomatoid tumor, NOS 9080/3 9055/0 Multicystic mesothelioma, benign Cystic mesothelioma, benign (C48._) Teratoma, malignant, NOS Embryonal teratoma Teratoblastoma, malignant Immature teratoma, malignant Immature teratoma, NOS 9055/1 Cystic mesothelioma, NOS (C48._) 9081/3 Teratocarcinoma Mixed embryonal carcinoma and teratoma 9082/3 Malignant teratoma, undifferentiated Malignant teratoma, anaplastic 9083/3 Malignant teratoma, intermediate 9084/0 Dermoid cyst, NOS Dermoid, NOS 906-909 GERM CELL NEOPLASMS 9060/3 Dysgerminoma 9061/3 Seminoma, NOS (C62._) 9062/3 Seminoma, anaplastic (C62._) Seminoma with high mitotic index (C62._) 95 Morphology –Numerical (continued) 9084/3 Teratoma with malignant transformation Dermoid cyst with malignant transformation (C56.9) Dermoid cyst with secondary tumor 9085/3 Mixed germ cell tumor Mixed teratoma and seminoma 9090/0 Struma ovarii, NOS (C56.9) 9090/3 Struma ovarii, malignant (C56.9) 9091/1 Strumal carcinoid (C56.9) Struma ovarii and carcinoid (C56.9) 9110/3 Mesonephroma, malignant Mesonephric adenocarcinoma Mesonephroma, NOS Wolffian duct carcinoma 912-916 BLOOD VESSEL TUMORS 9120/0 Hemangioma, NOS Angioma, NOS Chorioangioma (C58.9) 9120/3 Hemangiosarcoma Angiosarcoma 9121/0 Cavernous hemangioma 9122/0 Venous hemangioma 9123/0 Racemose hemangioma Arteriovenous hemangioma 9124/3 Kupffer cell sarcoma (C22.0) 9125/0 Epithelioid hemangioma Histiocytoid hemangioma 9130/0 Hemangioendothelioma, benign 9130/1 Hemangioendothelioma, NOS Angioendothelioma Kaposiform hemangioendothelioma 9130/3 Hemangioendothelioma, malignant Hemangioendothelial sarcoma 9131/0 Capillary hemangioma Hemangioma simplex Infantile hemangioma Plexiform hemangioma Juvenile hemangioma 910 TROPHOBLASTIC NEOPLASMS 9100/0 9100/1 9100/3 9101/3 Hydatidiform mole, NOS (C58.9) Hydatid mole (C58.9) Complete hydatidiform mole (C58.9) Invasive hydatidiform mole (C58.9) Chorioadenoma destruens (C58.9) Chorioadenoma (C58.9) Invasive mole, NOS (C58.9) Malignant hydatidiform mole (C58.9) Choriocarcinoma, NOS Chorionepithelioma Chorioepithelioma Choriocarcinoma combined with other germ cell elements Choriocarcinoma combined with teratoma Choriocarcinoma combined with embryonal carcinoma 9102/3 Malignant teratoma, trophoblastic 9103/0 Partial hydatidiform mole (C58.9) 9104/1 Placental site trophoblastic tumor (C58.9) 9132/0 Intramuscular hemangioma 9105/3 Trophoblastic tumor, epithelioid 9133/1 Epithelioid hemangioendothelioma, NOS 9133/3 Epithelioid hemangioendothelioma, malignant Intravascular bronchial alveolar tumor (C34._) [obs] 911 MESONEPHROMAS 9110/0 Mesonephroma, benign Mesonephric adenoma Wolffian duct adenoma 9135/1 Endovascular papillary angioendothelioma Dabska tumor 9110/1 Mesonephric tumor, NOS Wolffian duct tumor 9136/1 Spindle cell hemangioendothelioma Spindle cell angioendothelioma 96 Morphology –Numerical (continued) 9140/3 Kaposi sarcoma Multiple hemorrhagic sarcoma 9141/0 Angiokeratoma 9180/0 Osteoma, NOS (C40._, C41._) 9142/0 Verrucous keratotic hemangioma 9180/3 9150/0 Hemangiopericytoma, benign Osteosarcoma, NOS (C40._, C41._) Osteogenic sarcoma, NOS (C40._, C41._) Osteochondrosarcoma (C40._, C41._) Osteoblastic sarcoma (C40._, C41._) 9150/1 Hemangiopericytoma, NOS Hemangiopericytic meningioma (C70._) [obs] 9181/3 Chondroblastic osteosarcoma (C40._, C41._) 9150/3 Hemangiopericytoma, malignant 9182/3 Fibroblastic osteosarcoma (C40._, C41._) Osteofibrosarcoma (C40._, C41._) 9160/0 Angiofibroma, NOS Juvenile angiofibroma Fibrous papule of nose (C44.3) [obs] Involuting nevus (C44._) [obs] Giant cell angiofibroma Cellular angiofibroma 9183/3 Telangiectatic osteosarcoma (C40._, C41._) 9184/3 Osteosarcoma in Paget disease of bone (C40._, C41._) 918-924 OSSEOUS AND CHONDROMATOUS NEOPLASMS 9161/0 Acquired tufted hemangioma 9185/3 Small cell osteosarcoma (C40._, C41._) Round cell osteosarcoma (C40._, C41._) 9161/1 Hemangioblastoma Angioblastoma 9186/3 Central osteosarcoma (C40._, C41._) Conventional central osteosarcoma (C40._, C41._) Medullary osteosarcoma (C40._, C41._) 9187/3 Intraosseous well differentiated osteosarcoma (C40._, C41._) Intraosseous low grade osteosarcoma (C40._, C41._) 9191/0 Osteoid osteoma, NOS (C40._, C41._) 9192/3 Parosteal osteosarcoma (C40._, C41._) Juxtacortical osteosarcoma (C40._, C41._) 917 LYMPHATIC VESSEL TUMORS 9170/0 Lymphangioma, NOS Lymphangioendothelioma, NOS 9170/3 Lymphangiosarcoma Lymphangioendothelial sarcoma Lymphangioendothelioma, malignant 9171/0 Capillary lymphangioma 9172/0 Cavernous lymphangioma 9193/3 Periosteal osteosarcoma (C40._, C41._) 9173/0 Cystic lymphangioma Hygroma, NOS Cystic hygroma 9194/3 High grade surface osteosarcoma (C40._, C41._) 9195/3 Intracortical osteosarcoma (C40._, C41._) 9174/0 Lymphangiomyoma 9200/0 9174/1 Lymphangiomyomatosis Lymphangioleiomyomatosis Osteoblastoma, NOS (C40._, C41._) Giant osteoid osteoma (C40._, C41._) 9200/1 Aggressive osteoblastoma (C40._, C41._) 9175/0 Hemolymphangioma 9210/0 Osteochondroma (C40._, C41._) Cartilaginous exostosis (C40._, C41._) Osteocartilaginous exostosis (C40._, C41._) Ecchondroma (C40._, C41._) 97 Morphology –Numerical (continued) 9210/1 Osteochondromatosis, NOS (C40._, C41._) Ecchondrosis (C40._, C41._) 9220/0 Chondroma, NOS (C40._, C41._) Enchondroma (C40._, C41._) 9220/1 Chondromatosis, NOS 9220/3 Chondrosarcoma, NOS (C40._, C41._) Fibrochondrosarcoma (C40._, C41._) 9221/0 Juxtacortical chondroma (C40._, C41._) Periosteal chondroma (C40._, C41._) 9221/3 Juxtacortical chondrosarcoma (C40._, C41._) Periosteal chondrosarcoma (C40._, C41._) 9230/0 Chondroblastoma, NOS (C40._, C41._) Chondromatous giant cell tumor (C40._, C41._) Codman tumor (C40._, C41._) 9252/0 Tenosynovial giant cell tumor (C49._) Fibrous histiocytoma of tendon sheath (C49._) Giant cell tumor of tendon sheath (C49._) 9252/3 Malignant tenosynovial giant cell tumor (C49._) Giant cell tumor of tendon sheath, malignant (C49._) 926 MISCELLANEOUS BONE TUMORS (C40._, C41._) 9260/3 Ewing sarcoma Ewing tumor 9261/3 Adamantinoma of long bones (C40._) Tibial adamantinoma (C40.2) 9262/0 Ossifying fibroma Fibro-osteoma Osteofibroma 9230/3 Chondroblastoma, malignant (C40._, C41._) 9231/3 Myxoid chondrosarcoma 9240/3 Mesenchymal chondrosarcoma 9241/0 Chondromyxoid fibroma (C40._, C41._) 9242/3 Clear cell chondrosarcoma (C40._, C41._) 9270/0 Odontogenic tumor, benign 9243/3 Dedifferentiated chondrosarcoma (C40._, C41._) 9270/1 Odontogenic tumor, NOS 9270/3 Odontogenic tumor, malignant Odontogenic carcinoma Odontogenic sarcoma Primary intraosseous carcinoma Ameloblastic carcinoma 9271/0 Ameloblastic fibrodentinoma Dentinoma 9272/0 Cementoma, NOS Periapical cemental dysplasia Periapical cemento-osseous dysplasia 9273/0 Cementoblastoma, benign 9274/0 Cementifying fibroma Cemento-ossifying fibroma 9275/0 Gigantiform cementoma Florid osseous dysplasia 9280/0 Odontoma, NOS 9281/0 Compound odontoma 927-934 ODONTOGENIC TUMORS (C41._) 925 GIANT CELL TUMORS 9250/1 Giant cell tumor of bone, NOS (C40._, C41._) Osteoclastoma, NOS (C40._, C41._) 9250/3 Giant cell tumor of bone, malignant (C40._, C41._) Osteoclastoma, malignant (C40._, C41._) Giant cell sarcoma of bone (C40._, C41._) 9251/1 Giant cell tumor of soft parts, NOS 9251/3 Malignant giant cell tumor of soft parts 98 Morphology –Numerical (continued) 9282/0 Complex odontoma 9352/1 Craniopharyngioma, papillary (C75.2) 9290/0 Ameloblastic fibro-odontoma Fibroameloblastic odontoma 9360/1 Pinealoma (C75.3) 9361/1 Pineocytoma (C75.3) 9290/3 Ameloblastic odontosarcoma Ameloblastic fibrodentinosarcoma Ameloblastic fibro-odontosarcoma 9362/3 Pineoblastoma (C75.3) Mixed pineal tumor (C75.3) Mixed pineocytoma-pineoblastoma (C75.3) Pineal parenchymal tumor of intermediate differentiation (C75.3) Transitional pineal tumor (C75.3) 9363/0 Melanotic neuroectodermal tumor Retinal anlage tumor Melanoameloblastoma Melanotic progonoma 9364/3 Peripheral neuroectodermal tumor Neuroectodermal tumor, NOS Peripheral primitive neuroectodermal tumor, NOS PPNET 9365/3 Askin tumor 9370/3 Chordoma, NOS 9371/3 Chondroid chordoma 9372/3 Dedifferentiated chordoma 9373/0 Parachordoma 9300/0 Adenomatoid odontogenic tumor Adenoameloblastoma 9301/0 Calcifying odontogenic cyst 9302/0 Odontogenic ghost cell tumor 9310/0 Ameloblastoma, NOS Adamantinoma, NOS (except of long bones M-9261/3) 9310/3 Ameloblastoma, malignant Adamantinoma, malignant (except of long bones M-9261/3) 9311/0 Odontoameloblastoma 9312/0 Squamous odontogenic tumor 9320/0 Odontogenic myxoma Odontogenic myxofibroma 9321/0 Central odontogenic fibroma Odontogenic fibroma, NOS 9322/0 Peripheral odontogenic fibroma 9330/0 Ameloblastic fibroma 9330/3 Ameloblastic fibrosarcoma Ameloblastic sarcoma Odontogenic fibrosarcoma 9340/0 Calcifying epithelial odontogenic tumor Pindborg tumor 9341/1 Clear cell odontogenic tumor 9342/3 Odontogenic carcinosarcoma 938-948 GLIOMAS 9380/3 Glioma, malignant (C71._) Glioma, NOS (except nasal glioma, not neoplastic) (C71._) 9381/3 Gliomatosis cerebri (C71._) 9382/3 Mixed glioma (C71._) Oligoastrocytoma (C71._) Anaplastic oligoastrocytoma (C71._) 9383/1 Subependymoma (C71._) Subependymal glioma (C71._) Subependymal astrocytoma, NOS (C71._) Mixed subependymoma-ependymoma (C71._) 9384/1 Subependymal giant cell astrocytoma (C71._) 935-937 MISCELLANEOUS TUMORS 9350/1 Craniopharyngioma (C75.2) Rathke pouch tumor (C75.1) 9351/1 Craniopharyngioma, adamantinomatous (C75.2) 99 Morphology –Numerical (continued) 9390/0 Choroid plexus papilloma, NOS (C71.5) 9430/3 Astroblastoma (C71._) 9390/1 Atypical choroid plexus papilloma (C71.5) 9440/3 9390/3 Choroid plexus carcinoma (C71.5) Choroid plexus papilloma, anaplastic (C71.5) Choroid plexus papilloma, malignant (C71.5) Glioblastoma, NOS (C71._) Glioblastoma multiforme (C71._) Spongioblastoma multiforme (C71._) 9441/3 Giant cell glioblastoma (C71._) Monstrocellular sarcoma (C71._) [obs] 9442/1 Gliofibroma (C71._) 9442/3 Gliosarcoma (C71._) Glioblastoma with sarcomatous component (C71._) 9444/1 Chordoid glioma (C71._) Chordoid glioma of third ventricle (C71.5) 9450/3 Oligodendroglioma, NOS (C71._) 9451/3 Oligodendroglioma, anaplastic (C71._) 9460/3 Oligodendroblastoma (C71._) [obs] 9470/3 Medulloblastoma, NOS (C71.6) Melanotic medulloblastoma (C71.6) 9471/3 Desmoplastic nodular medulloblastoma (C71.6) Desmoplastic medulloblastoma (C71.6) Circumscribed arachnoidal cerebellar sarcoma (C71.6) [obs] 9391/3 Ependymoma, NOS (C71._) Epithelial ependymoma (C71._) Cellular ependymoma (C71._) Clear cell ependymoma (C71._) Tanycytic ependymoma (C71._) 9392/3 Ependymoma, anaplastic (C71._) Ependymoblastoma (C71._) 9393/3 Papillary ependymoma (C71._) 9394/1 Myxopapillary ependymoma (C72.0) 9400/3 Astrocytoma, NOS (C71._) Astrocytic glioma (C71._) Astroglioma (C71._) [obs] Diffuse astrocytoma (C71._) Astrocytoma, low grade (C71._) Diffuse astrocytoma, low grade (C71._) Cystic astrocytoma (C71._) [obs] 9401/3 Astrocytoma, anaplastic (C71._) 9410/3 Protoplasmic astrocytoma (C71._) 9472/3 Medullomyoblastoma (C71.6) 9411/3 Gemistocytic astrocytoma (C71._) Gemistocytoma (C71._) 9473/3 9412/1 Desmoplastic infantile astrocytoma (C71._) Desmoplastic infantile ganglioglioma (C71._) Primitive neuroectodermal tumor, NOS PNET, NOS Central primitive neuroectodermal tumor, NOS (C71._) CPNET (C71._) Supratentorial PNET (C71._) 9474/3 Large cell medulloblastoma (C71.6) 9413/0 Dysembryoplastic neuroepithelial tumor 9480/3 Cerebellar sarcoma, NOS (C71.6) [obs] 9420/3 Fibrillary astrocytoma (C71._) Fibrous astrocytoma (C71._) 9421/1 Pilocytic astrocytoma (C71._) Piloid astrocytoma (C71._) Juvenile astrocytoma (C71._) Spongioblastoma, NOS (C71._) [obs] 9423/3 9424/3 949-952 NEUROEPITHELIOMATOUS NEOPLASMS Polar spongioblastoma (C71._) Spongioblastoma polare (C71._) Primitive polar spongioblastoma (C71._) [obs] Pleomorphic xanthoastrocytoma (C71._) 100 9490/0 Ganglioneuroma 9490/3 Ganglioneuroblastoma 9491/0 Ganglioneuromatosis 9492/0 Gangliocytoma Morphology –Numerical (continued) 9493/0 Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) (C71.6) 9522/3 Olfactory neuroblastoma (C30.0) Esthesioneuroblastoma (C30.0) 9500/3 Neuroblastoma, NOS Sympathicoblastoma Central neuroblastoma (C71._) 9523/3 Olfactory neuroepithelioma (C30.0) Esthesioneuroepithelioma (C30.0) 9501/0 Medulloepithelioma, benign (C69.4) Diktyoma, benign (C69._) 9501/3 Medulloepithelioma, NOS Diktyoma, malignant (C69._) 953 MENINGIOMAS (C70._) 9502/0 Teratoid medulloepithelioma, benign (C69.4) 9502/3 Teratoid medulloepithelioma 9503/3 Neuroepithelioma, NOS 9504/3 Spongioneuroblastoma 9505/1 Ganglioglioma, NOS Glioneuroma [obs] Neuroastrocytoma [obs] 9505/3 Ganglioglioma, anaplastic 9506/1 Central neurocytoma Neurocytoma Cerebellar liponeurocytoma (C71.6) Lipomatous medulloblastoma (C71.6) Neurolipocytoma (C71.6) Medullocytoma (C71.6) 9530/0 Meningioma, NOS Microcystic meningioma Secretory meningioma Lymphoplasmacyte-rich meningioma Metaplastic meningioma 9530/1 Meningiomatosis, NOS Diffuse meningiomatosis Multiple meningiomas 9530/3 Meningioma, malignant Meningioma, anaplastic Leptomeningeal sarcoma Meningeal sarcoma Meningothelial sarcoma 9531/0 Meningothelial meningioma Endotheliomatous meningioma Syncytial meningioma 9532/0 Fibrous meningioma Fibroblastic meningioma 9533/0 Psammomatous meningioma 9534/0 Angiomatous meningioma 9535/0 Hemangioblastic meningioma [obs] Angioblastic meningioma [obs] 9537/0 Transitional meningioma Mixed meningioma 9538/1 Clear cell meningioma Chordoid meningioma 9507/0 Pacinian tumor 9508/3 Atypical teratoid/rhabdoid tumor (C71._) 9510/0 Retinocytoma (C69.2) 9510/3 Retinoblastoma, NOS (C69.2) 9511/3 Retinoblastoma, differentiated (C69.2) 9512/3 Retinoblastoma, undifferentiated (C69.2) 9513/3 Retinoblastoma, diffuse (C69.2) 9538/3 Papillary meningioma Rhabdoid meningioma 9514/1 Retinoblastoma, spontaneously regressed (C69.2) 9539/1 Atypical meningioma 9520/3 Olfactory neurogenic tumor 9539/3 Meningeal sarcomatosis 9521/3 Olfactory neurocytoma (C30.0) Esthesioneurocytoma (C30.0) 101 Morphology –Numerical (continued) 954-957 NERVE SHEATH TUMORS 9540/0 Neurofibroma, NOS 9540/1 Neurofibromatosis, NOS Multiple neurofibromatosis Von Recklinghausen disease (except of bone) Recklinghausen disease (except of bone) 9540/3 9571/3 958 GRANULAR CELL TUMORS AND ALVEOLAR SOFT PART SARCOMAS Malignant peripheral nerve sheath tumor MPNST, NOS Neurofibrosarcoma [obs] Neurogenic sarcoma [obs] Neurosarcoma [obs] MPNST with glandular differentiation Epithelioid MPNST MPNST with mesenchymal differentiation Melanotic MPNST Melanotic psammomatous MPNST 9541/0 Melanotic neurofibroma 9550/0 Plexiform neurofibroma Plexiform neuroma 9560/0 Neurilemoma, NOS Schwannoma, NOS Neurinoma Acoustic neuroma (C72.4) Pigmented schwannoma Melanotic schwannoma Plexiform schwannoma Cellular schwannoma Degenerated schwannoma Ancient schwannoma Psammomatous schwannoma 9560/1 Neurinomatosis 9560/3 Neurilemoma, malignant [obs] Malignant schwannoma, NOS [obs] Neurilemosarcoma [obs] 9561/3 Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation MPNST with rhabdomyoblastic differentiation Triton tumor, malignant Malignant schwannoma with rhabdomyoblastic differentiation 9562/0 Neurothekeoma Nerve sheath myxoma 9570/0 Neuroma, NOS 9571/0 Perineurioma, NOS Intraneural perineurioma Soft tissue perineurioma Perineurioma, malignant Perineural MPNST 9580/0 Granular cell tumor, NOS Granular cell myoblastoma, NOS 9580/3 Granular cell tumor, malignant Granular cell myoblastoma, malignant 9581/3 Alveolar soft part sarcoma 9582/0 Granular cell tumor of the sellar region (C75.1) 959-972 HODGKIN AND NON-HODGKIN LYMPHOMAS 959 102 MALIGNANT LYMPHOMAS, NOS OR DIFFUSE 9590/3 Malignant lymphoma, NOS Lymphoma, NOS Microglioma (C71._) [obs] 9591/3 Malignant lymphoma, non-Hodgkin, NOS Non-Hodgkin lymphoma, NOS B cell lymphoma, NOS Malignant lymphoma, non-cleaved cell, NOS Malignant lymphoma, diffuse, NOS Malignant lymphoma, lymphocytic, intermediate differentiation, nodular [obs] Malignant lymphoma, small cell, noncleaved, diffuse [obs] Malignant lymphoma, undifferentiated cell, non-Burkitt [obs] Malignant lymphoma, undifferentiated cell type, NOS [obs] Lymphosarcoma, NOS [obs] Lymphosarcoma, diffuse [obs] Reticulum cell sarcoma, NOS [obs] Reticulum cell sarcoma, diffuse [obs] Reticulosarcoma, NOS [obs] Reticulosarcoma, diffuse [obs] Malignant lymphoma, small cleaved cell, diffuse [obs] Malignant lymphoma, lymphocytic, poorly differentiated, diffuse [obs] Malignant lymphoma, small cleaved cell, NOS [obs] Malignant lymphoma, cleaved cell, NOS [obs] Morphology –Numerical (continued) 9596/3 Composite Hodgkin and non-Hodgkin lymphoma 965-966 9664/3 Hodgkin lymphoma, nodular sclerosis, cellular phase Classical Hodgkin lymphoma, nodular sclerosis, cellular phase 9665/3 Hodgkin lymphoma, nodular sclerosis, grade 1 Classical Hodgkin lymphoma, nodular sclerosis, grade 1 Hodgkin disease, nodular sclerosis, lymphocyte predominance Hodgkin disease, nodular sclerosis, mixed cellularity 9667/3 Hodgkin lymphoma, nodular sclerosis, grade 2 Classical Hodgkin lymphoma, nodular sclerosis, grade 2 Hodgkin disease, nodular sclerosis, lymphocyte depletion Hodgkin disease, nodular sclerosis, syncytial variant HODGKIN LYMPHOMA 9650/3 Hodgkin lymphoma, NOS Hodgkin disease, NOS Malignant lymphoma, Hodgkin 9651/3 Hodgkin lymphoma, lymphocyte-rich Classical Hodgkin lymphoma, lymphocyterich Hodgkin disease, lymphocyte predominance, NOS [obs] Hodgkin disease, lymphocytichistiocytic predominance [obs] Hodgkin disease, lymphocyte predominance, diffuse [obs] 9652/3 Hodgkin lymphoma, mixed cellularity, NOS Classical Hodgkin lymphoma, mixed cellularity, NOS 9653/3 Hodgkin lymphoma, lymphocyte depletion, NOS Classical Hodgkin lymphoma, lymphocyte depletion, NOS 967-972 9654/3 Hodgkin lymphoma, lymphocyte depletion, diffuse fibrosis Classical Hodgkin lymphoma, lymphocyte depletion, diffuse fibrosis 9655/3 Hodgkin lymphoma, lymphocyte depletion, reticular Classical Hodgkin lymphoma, lymphocyte depletion, reticular 9659/3 Hodgkin lymphoma, nodular lymphocyte predominance Hodgkin lymphoma, lymphocyte predominance, nodular Hodgkin paragranuloma, NOS [obs] Hodgkin paragranuloma, nodular [obs] 9661/3 Hodgkin granuloma [obs] 9662/3 Hodgkin sarcoma [obs] 9663/3 Hodgkin lymphoma, nodular sclerosis, NOS Classical Hodgkin lymphoma, nodular sclerosis, NOS Hodgkin disease, nodular sclerosis, NOS NON-HODGKIN LYMPHOMAS 967-969 MATURE B-CELL LYMPHOMAS 103 9670/3 Malignant lymphoma, small B lymphocytic, NOS (see also M-9823/3) Malignant lymphoma, small lymphocytic, NOS Malignant lymphoma, lymphocytic, well differentiated, diffuse Malignant lymphoma, lymphocytic, NOS Malignant lymphoma, lymphocytic, diffuse, NOS Malignant lymphoma, small cell, NOS Malignant lymphoma, small lymphocytic, diffuse Malignant lymphoma, small cell diffuse 9671/3 Malignant lymphoma, lymphoplasmacytic (see also M-9761/3) Malignant lymphoma, lymphoplasmacytoid immunocytoma [obs] Malignant lymphoma, plasmacytoid [obs] Plasmacytic lymphoma [obs] Morphology –Numerical (continued) 9673/3 9675/3 Mantle cell lymphoma Includes all variants: blastic, pleomorphic, small cell Mantle zone lymphoma [obs] Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse [obs] Malignant lymphoma, centrocytic [obs] Malignant lymphomatous polyposis Malignant lymphoma, mixed small and large cell, diffuse [obs] (see also M-9690/3) Malignant lymphoma, mixed lymphocytic-histiocytic, diffuse [obs] Malignant lymphoma, mixed cell type, diffuse [obs] Malignant lymphoma, centroblasticcentrocytic, NOS [obs] Malignant lymphoma, centroblasticcentrocytic, diffuse [obs] 9678/3 Primary effusion lymphoma 9679/3 Mediastinal large B-cell lymphoma (C38.3) Thymic large B-cell lymphoma (C37.9) 9680/3 Angioendotheliomatosis Angiotropic lymphoma T-cell rich large B-cell lymphoma Histiocyte-rich large B-cell lymphoma T-cell rich/histiocyte-rich large B-cell lymphoma Anaplastic large B-cell lymphoma Malignant lymphoma, large B-cell, diffuse, NOS Diffuse large B-cell lymphoma, NOS Malignant lymphoma, large cell, NOS Malignant lymphoma, large B-cell, NOS Malignant lymphoma, histiocytic, NOS [obs] Malignant lymphoma, histiocytic, diffuse Malignant lymphoma, large cell, cleaved and noncleaved [obs] Malignant lymphoma, large cell, diffuse, NOS [obs] Malignant lymphoma, large cleaved cell, NOS [obs] Malignant lymphoma, large cell, cleaved, diffuse Malignant lymphoma, large cell, cleaved, NOS [obs] Malignant lymphoma, large cell, noncleaved, diffuse Malignant lymphoma, large cell, noncleaved, NOS Malignant lymphoma, noncleaved, diffuse, NOS [obs] Malignant lymphoma, noncleaved, NOS Malignant lymphoma, large B-cell, diffuse, centroblastic, NOS Malignant lymphoma, centroblastic, NOS Malignant lymphoma, centroblastic, diffuse Intravascular large B-cell lymphoma (C49.9) Intravascular B-cell lymphoma 104 9684/3 Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS Malignant lymphoma, immunoblastic, NOS Immunoblastic sarcoma [obs] Malignant lymphoma, large cell, immunoblastic Plasmablastic lymphoma 9687/3 Burkitt lymphoma, NOS (see also M-9826/3) Includes all variants Burkitt tumor [obs] Malignant lymphoma, undifferentiated, Burkitt type [obs] Malignant lymphoma, small noncleaved, Burkitt type [obs] Burkitt-like lymphoma 9689/3 Splenic marginal zone B-cell lymphoma (C42.2) Splenic marginal zone lymphoma, NOS (C42.2) Splenic lymphoma with villous lymphocytes (C42.2) 9690/3 Follicular lymphoma, NOS (see also M-9675/3) Malignant lymphoma, follicular, NOS Malignant lymphoma, follicle center, follicular Malignant lymphoma, follicle center, NOS Malignant lymphoma, centroblasticcentrocytic, follicular [obs] Malignant lymphoma, nodular, NOS [obs] Malignant lymphoma, lymphocytic, nodular, NOS [obs] 9691/3 Follicular lymphoma, grade 2 Malignant lymphoma, mixed small cleaved and large cell, follicular [obs] Malignant lymphoma, mixed lymphocytic-histiocytic, nodular [obs] Malignant lymphoma, mixed cell type, follicular [obs] Malignant lymphoma, mixed cell type, nodular [obs] Morphology –Numerical (continued) 9695/3 Follicular lymphoma, grade 1 Malignant lymphoma, small cleaved cell, follicular [obs] Follicular lymphoma, small cleaved cell Malignant lymphoma, lymphocytic, poorly differentiated, nodular [obs] 9705/3 Angioimmunoblastic T-cell lymphoma Peripheral T-cell lymphoma, AILD (Angioimmunoblastic Lymphadenopathy with Dysproteinemia) [obs] Angioimmunoblastic lymphoma [obs] 9698/3 Follicular lymphoma, grade 3 Malignant lymphoma, large cell, follicular, NOS Malignant lymphoma, large cell, noncleaved, follicular [obs] Malignant lymphoma, histiocytic, nodular [obs] Malignant lymphoma, noncleaved cell, follicular, NOS [obs] Malignant lymphoma, large cleaved cell, follicular [obs] Malignant lymphoma, centroblastic, follicular Malignant lymphoma, lymphocytic, well differentiated, nodular [obs] 9708/3 Subcutaneous panniculitis-like T-cell lymphoma 9709/3 Cutaneous T-cell lymphoma, NOS (C44._) Cutaneous lymphoma, NOS (C44._) [obs] 9714/3 Anaplastic large cell lymphoma, T cell and Null cell type Large cell (Ki-1+) lymphoma [obs] Anaplastic large cell lymphoma, NOS Anaplastic large cell lymphoma, CD30+ 9716/3 Hepatosplenic γδ (gamma-delta) cell lymphoma Marginal zone B-cell lymphoma, NOS Marginal zone lymphoma, NOS Mucosal-associated lymphoid tissue lymphoma MALT lymphoma Bronchial-associated lymphoid tissue lymphoma BALT lymphoma Skin-associated lymphoid tissue lymphoma SALT lymphoma Monocytoid B-cell lymphoma Nodal marginal zone lymphoma 9717/3 Intestinal T-cell lymphoma Enteropathy type intestinal T-cell lymphoma Enteropathy associated T-cell lymphoma 9718/3 Primary cutaneous CD30+ T-cell lymphoproliferative disorder (C44._) Lymphomatoid papulosis (C44._) Primary cutaneous anaplastic large cell lymphoma (C44._) Primary cutaneous CD30+ large T-cell lymphoma (C44._) 9719/3 NK/T-cell lymphoma, nasal and nasal-type T/NK-cell lymphoma Angiocentric T-cell lymphoma [obs] Malignant reticulosis, NOS [obs] Malignant midline reticulosis [obs] Polymorphic reticulosis [obs] 9699/3 970-971 MATURE T- AND NK-CELL LYMPHOMAS 9700/3 Mycosis fungoides (C44._) Pagetoid reticulosis 9701/3 Sezary syndrome Sezary disease 9702/3 Mature T-cell lymphoma, NOS Peripheral T-cell lymphoma, NOS T-cell lymphoma, NOS Peripheral T-cell lymphoma, pleomorphic small cell Peripheral T-cell lymphoma, pleomorphic medium and large cell Peripheral T-cell lymphoma, large cell T-zone lymphoma Lymphoepithelioid lymphoma Lennert lymphoma 972 PRECURSOR CELL LYMPHOBLASTIC LYMPHOMA 105 9727/3 Precursor cell lymphoblastic lymphoma, NOS (see also M-9835/3) Malignant lymphoma, lymphoblastic, NOS (see also M-9835/3) Malignant lymphoma, convoluted cell [obs] Lymphoblastoma [obs] 9728/3 Precursor B-cell lymphoblastic lymphoma (see also M-9836/3) Morphology –Numerical (continued) 9729/3 Precursor T-cell lymphoblastic lymphoma (see also M-9837/3) 9753/1 Langerhans cell histiocytosis, multifocal Langerhans cell histiocytosis, poly-ostotic Hand-Schuller-Christian disease [obs] 9754/3 Langerhans cell histiocytosis, disseminated Langerhans cell histiocytosis, generalized Letterer-Siwe disease Acute progressive histiocytosis X Nonlipid reticuloendotheliosis [obs] 9755/3 Histiocytic sarcoma True histiocytic lymphoma 9756/3 Langerhans cell sarcoma 9757/3 Interdigitating dendritic cell sarcoma Interdigitating cell sarcoma Dendritic cell sarcoma, NOS 9758/3 Follicular dendritic cell sarcoma Follicular dendritic cell tumor 973 PLASMA CELL TUMORS 9731/3 9732/3 9733/3 9734/3 Plasmacytoma, NOS Plasmacytoma of bone (C40._, C41._) Plasma cell tumor Solitary myeloma Solitary plasmacytoma Multiple myeloma (C42.1) Myeloma, NOS (C42.1) Myelomatosis (C42.1) Plasma cell myeloma (C42.1) Plasma cell leukemia (C42.1) Plasmacytic leukemia (C42.1) Plasmacytoma, extramedullary (not occurring in bone) 976 IMMUNOPROLIFERATIVE DISEASES 974 MAST CELL TUMORS 9760/3 Immunoproliferative disease, NOS 9740/1 Mastocytoma, NOS Mast cell tumor, NOS 9761/3 Waldenstrom macroglobulinemia (C42.0) (see also M-9671/3) 9740/3 Mast cell sarcoma Malignant mast cell tumor Malignant mastocytoma 9762/3 9741/3 Malignant mastocytosis Systemic tissue mast cell disease Heavy chain disease, NOS Alpha heavy chain disease Mu heavy chain disease Gamma heavy chain disease Franklin disease 9764/3 9742/3 Mast cell leukemia (C42.1) Immunoproliferative small intestinal disease (C17._) Mediterranean lymphoma 9765/1 Monoclonal gammopathy of undetermined significance MGUS Monoclonal gammopathy, NOS 975 NEOPLASMS OF HISTIOCYTES AND ACCESSORY LYMPHOID CELLS 9750/3 Malignant histiocytosis Histiocytic medullary reticulosis [obs] 9766/1 Angiocentric immunoproliferative lesion Lymphoid granulomatosis 9751/1 Langerhans cell histiocytosis, NOS Langerhans cell granulomatosis Histiocytosis X, NOS [obs] 9767/1 Angioimmunoblastic lymphadenopathy (AIL) Immunoblastic lymphadenopathy (IBL) [obs] 9752/1 Langerhans cell histiocytosis, unifocal Langerhans cell granulomatosis, unifocal Langerhans cell histiocytosis, mono-ostotic Eosinophilic granuloma 9768/1 T-gamma lymphoproliferative disease 106 Morphology –Numerical (continued) 9769/1 Immunoglobulin deposition disease Systemic light chain disease Primary amyloidosis 9827/3 Adult T-cell leukemia/lymphoma (HTLV-1 positive) Includes all variants Adult T-cell lymphoma/leukemia Adult T-cell lymphoma Adult T-cell leukemia 9831/1 T-cell large granular lymphocytic leukemia T-cell large granular lymphocytosis NK-cell large granular lymphocytic leukemia Large granular lymphocytosis, NOS 9832/3 Prolymphocytic leukemia, NOS 9833/3 Prolymphocytic leukemia, B-cell type 9834/3 Prolymphocytic leukemia, T-cell type 9835/3 Lymphoid leukemia, NOS Lymphocytic leukemia, NOS [obs] Lymphatic leukemia, NOS [obs] Subacute lymphoid leukemia [obs] Subacute lymphocytic leukemia [obs] Subacute lymphatic leukemia [obs] Aleukemic lymphoid leukemia [obs] Aleukemic lymphocytic leukemia [obs] Aleukemic lymphatic leukemia [obs] Lymphosarcoma cell leukemia [obs] Precursor cell lymphoblastic leukemia, NOS (see also M-9727/3) Precursor cell lymphoblastic leukemia, not phenotyped Acute lymphoblastic leukemia, NOS (see also M-9727/3) Acute lymphoblastic leukemia, precursor- cell type Acute lymphoblastic leukemialymphoma, NOS Acute lymphocytic leukemia Acute lymphoid leukemia Acute lymphatic leukemia Lymphoblastic leukemia, NOS FAB L1 [obs] Acute lymphoblastic leukemia, L2 type, NOS FAB L2 9836/3 B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (see also M-9670/3) Chronic lymphocytic leukemia, B-cell type (includes all variants of BCLL) Chronic lymphocytic leukemia Chronic lymphoid leukemia Chronic lymphatic leukemia Precursor B-cell lymphoblastic leukemia (see also M-9728/3) Pro-B ALL Common precursor B ALL Pre-B ALL Pre-pre-B ALL Common ALL c-ALL 9837/3 Precursor T-cell lymphoblastic leukemia (see also M-9729/3) Pro-T ALL Pre-T ALL Cortical T ALL Mature T ALL 980-994 LEUKEMIAS 980 LEUKEMIAS, NOS (C42.1) 9800/3 9801/3 9805/3 Leukemia, NOS Subacute leukemia, NOS [obs] Chronic leukemia, NOS [obs] Aleukemic leukemia, NOS [obs] Acute leukemia, NOS Blast cell leukemia Undifferentiated leukemia Stem cell leukemia Acute biphenotypic leukemia Acute mixed lineage leukemia Acute bilineal leukemia 982-983 LYMPHOID LEUKEMIAS (C42.1) 9820/3 9823/3 9826/3 Burkitt cell leukemia (see also M-9687/3) Acute leukemia, Burkitt type [obs] B-ALL [obs] FAB L3 [obs] Burkitt cell leukemia Acute lymphoblastic leukemia, mature B-cell type 107 Morphology –Numerical (continued) 984-993 MYELOID LEUKEMIAS (C42.1) 9840/3 9860/3 9871/3 Acute myeloid leukemia with abnormal marrow eosinophils Includes all variants Acute myeloid leukemia, inv(16)(p13;q22) Acute myeloid leukemia, t(16;16)(p13;q11) Acute myeloid leukemia, CBFbeta/MYH11 Acute myelomonocytic leukemia with abnormal eosinophils FAB M4Eo 9872/3 Acute myeloid leukemia, minimal differentiation Acute myeloblastic leukemia FAB M0 9873/3 Acute myeloid leukemia without maturation FAB M1 9874/3 Acute myeloid leukemia with maturation FAB M2, NOS 9875/3 Chronic myelogenous leukemia, BCR/ABL positive Chronic myelogenous leukemia, Philadelphia chromosome (Ph1) positive Chronic myelogenous leukemia, t(9;22)(q34;q11) Chronic granulocytic leukemia, Philadelphia chromosome (Ph1) positive Chronic granulocytic leukemia, t(9;22)(q34;q11) Chronic granulocytic leukemia, BCR/ABL Acute myeloid leukemia, M6 type Acute erythroid leukemia M6A M6B Erythroleukemia FAB M6 AML M6 Erythremic myelosis, NOS Acute erythremia [obs] Di Guglielmo disease [obs] Acute erythremic myelosis [obs] Myeloid leukemia, NOS Non-lymphocytic leukemia, NOS Granulocytic leukemia, NOS Myelogenous leukemia, NOS Myelomonocytic leukemia, NOS Myelocytic leukemia, NOS Subacute myeloid leukemia [obs] Subacute granulocytic leukemia [obs] Subacute myelogenous leukemia [obs] Aleukemic myeloid leukemia [obs] Aleukemic granulocytic leukemia [obs] Aleukemic myelogenous leukemia [obs] Eosinophilic leukemia Monocytic leukemia, NOS Subacute monocytic leukemia [obs] Chronic monocytic leukemia [obs] Aleukemic monocytic leukemia [obs] 9861/3 Acute myeloid leukemia, NOS (FAB or WHO type not specified) (see also M-9930/3) Acute non-lymphocytic leukemia Acute granulocytic leukemia Acute myelogenous leukemia Acute myelocytic leukemia 9863/3 Chronic myeloid leukemia, NOS Chronic granulocytic leukemia, NOS Chronic myelogenous leukemia, NOS Chronic myelocytic leukemia, NOS 9876/3 Atypical chronic myeloid leukemia, BCR/ABL negative Atypical chronic myeloid leukemia, Philadelphia chromosome (Ph1) negative 9866/3 Acute promyelocytic leukemia, t(15;17)(q22;q11-12) Acute promyelocytic leukemia, PML/RAR- alpha Acute myeloid leukemia, t(15:17)(q22;q11-12) Acute myeloid leukemia, PML/RARalpha Acute promyelocytic leukemia, NOS FAB M3 (includes all variants) 9891/3 Acute monocytic leukemia Acute monoblastic leukemia Monoblastic leukemia, NOS FAB M5 (includes all variants) 9895/3 Acute myeloid leukemia with multilineage dysplasia Acute myeloid leukemia with prior myelodysplastic syndrome Acute myeloid leukemia without prior myelodysplastic syndrome 9867/3 Acute myelomonocytic leukemia FAB M4 9870/3 Acute basophilic leukemia 108 Morphology –Numerical (continued) 9896/3 9897/3 9910/3 9920/3 Acute myeloid leukemia, t(8;21)(q22;q22) Acute myeloid leukemia, AML1(CBFalpha)/ETO FAB M2, t(8;21)(q22;q22) FAB M2, AML1(CBF-alpha)/ETO 995-996 CHRONIC MYELOPROLIFERATIVE DISORDERS (C42.1) Acute myeloid leukemia, 11q23 abnormalities Acute myeloid leukemia, MLL Acute megakaryoblastic leukemia Megakaryocytic leukemia FAB M7 Therapy-related acute myeloid leukemia, NOS Therapy-related acute myeloid leukemia, alkylating agent related Therapy-related acute myeloid leukemia, epipodophyllotoxin-related 9930/3 Myeloid sarcoma (see also M-9861/3) Granulocytic sarcoma Chloroma 9931/3 Acute panmyelosis with myelofibrosis (C42.1) Acute panmyelosis, NOS Acute myelofibrosis Acute myelosclerosis, NOS Malignant myelosclerosis [obs] 9950/3 Polycythemia vera Polycythemia rubra vera Proliferative polycythemia Chronic erythremia [obs] 9960/3 Chronic myeloproliferative disease, NOS Chronic myeloproliferative disorder 9961/3 Myelosclerosis with myeloid metaplasia Myelofibrosis as a result of myeloproliferative disease Chronic idiopathic myelofibrosis Agnogenic myeloid metaplasia Megakaryocytic myelosclerosis Myelofibrosis with myeloid metaplasia 9962/3 Essential thrombocythemia Idiopathic thrombocythemia Essential hemorrhagic thrombocythemia Idiopathic hemorrhagic thrombocythemia 9963/3 Chronic neutrophilic leukemia 9964/3 Hypereosinophilic syndrome Chronic eosinophilic leukemia 997 OTHER HEMATOLOGIC DISORDERS 9940/3 9945/3 9946/3 9948/3 994 OTHER LEUKEMIAS (C42.1) 9970/1 Lymphoproliferative disorder, NOS Lymphoproliferative disease, NOS Hairy cell leukemia (C42.1) Hairy cell leukemia variant Leukemic reticuloendotheliosis 9975/1 Myeloproliferative disease, NOS Chronic myelomonocytic leukemia, NOS Chronic myelomonocytic leukemia, Type I Chronic myelomonocytic leukemia, Type II Chronic myelomonocytic leukemia in transformation [obs] 998 MYELODYSPLASTIC SYNDROMES (C42.1) Juvenile myelomonocytic leukemia Juvenile chronic myelomonocytic leukemia 9980/3 Refractory anemia Refractory anemia without sideroblasts 9982/3 Refractory anemia with sideroblasts Refractory anemia with ringed sideroblasts RARS 9983/3 Refractory anemia with excess blasts RAEB RAEB I RAEB II Aggressive NK-cell leukemia 109 Morphology –Numerical (continued) 9984/3 Refractory anemia with excess blasts in transformation [obs] RAEB-T 9985/3 Refractory cytopenia with multilineage dysplasia 9986/3 Myelodysplastic syndrome with 5q deletion (5q–) syndrome 9987/3 Therapy-related myelodysplastic syndrome, NOS Therapy-related myelodysplastic syndrome, alkylating agent related Therapy-related myelodysplastic syndrome, epipodophyllotoxin-related 9989/3 Myelodysplastic syndrome, NOS Preleukemia [obs] Preleukemic syndrome [obs] 110 ANATOMISTEN SIJAINTIPAIKKOJEN AAKKOSELLINEN HAKEMISTO NOS - Not Otherwise Specified - tarkemmin määrittämätön C00.1 A C76.2 Abdomen, NOS C41.4 Acetabulum C57.4 C57.4 Adnexa uteri Adnexa, NOS C72.5 Aivohermo, NOS C70.0 Aivokalvot C71.5 C71.7 C71.5 C71.5 Aivokammio, kolmas, NOS Aivokammio, neljäs, NOS Aivokammio, NOS Aivokammio, -sivu, NOS C71.0 Aivokuori, Iso- C71.8 Aivokurkiainen C75.1 Aivolisäke C75.1 Aivolisäkekuoppa C71.7 Aivorunko C71.7 Aivosilta C72.8 C71.8 C71.0 C71.9 C71.6 Aivot ja keskushermosto, eri alueisiin ulottuva leesio (Huom. aivojen ja keskushermoston kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C70-C72.5.) Aivot, eri alueisiin ulottuva leesio Aivot, IsoAivot, NOS Aivot, Pikku-, NOS C44.3 Ala nasi C44.0 C00.4 Alahuuli, iho Alahuuli, limakalvo C00.1 C00.4 C00.1 Alahuuli, NOS (ei sisällä alahuulen ihoa C44.0) Alahuuli, punaosa Alahuuli, sisäpinta Alahuuli, ulkopinta C03.1 Alaien C03.1 Alaleuka, hammaskuopan limakalvo Alaleuka, hammaskuoppa Alaleuka, hammaskuoppaharjanteen limakalvo C03.1 C03.1 C41.1 Alaleukaluu C13.8 Alanielu, eri alueisiin ulottuva leesio Alanielu, NOS Alanielu, seinä Alanielu, takaseinä C13.9 C13.9 C13.2 C44.7 C77.4 C40.2 C40.3 C76.5 C40.2 C49.2 C47.2 111 Alaraaja, iho Alaraaja, imusolmukkeet Alaraaja, luu Alaraaja, lyhyet luut ja niiden nivelet Alaraaja, NOS Alaraaja, pitkät luut ja niiden nivelet Alaraaja, side- tai pehmytkudos Alaraaja, ääreishermot tai autonominen hermosto C03.9 Alveolus, NOS C24.1 Ampulla Vateri C30.1 C16.3 Antrum mastoideum Antrum pyloricum C44.5 C21.0 Anus, iho Anus, NOS C49.4 Aorta abdominalis Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C47.4 C47.1 Autonominen hermosto, vatsa Autonominen hermosto, yläraaja C76.1 Axilla, NOS C41.2 Axis C49.3 Aortta, NOS C75.5 Aorttakeränen ja muut paragangliot C49.1 C49.2 Aponeurosis palmaris Aponeurosis plantaris C18.1 Appendix vermiformis C70.0 C70.9 C70.1 Arachnoidea mater, kallon sisäinen Arachnoidea mater, NOS Arachnoidea mater, selkäytimen C51.0 Bartholinin rauhanen C09.1 Arcus palatoglossus C71.0 Basaaliganglio C49.3 C49.0 C49.2 C49.5 C49.4 C49.1 C49.4 C49.3 C49.3 C49.1 Arteria axillaris Arteria carotis Arteria femoralis Arteria iliaca Arteria mesenterica Arteria radialis Arteria renalis Arteria subclavia Arteria thoracica interna Arteria ulnaris C04.9 Basis oris, NOS C10.4 Brankiaalikysta (kasvaimen sijaintipaikkana) C34.0 Bronchus principalis C68.0 Bulbouretraalirauhanen C69.4 Bulbus oculi C13.1 Aryepiglottis, alanielun puoleinen osa Aryepiglottis, kurkunpään puoleinen osa C49.9 Bursa, NOS C41.2 Atlas C18.0 Caecum C38.0 Atrium cordis C22.1 Canaliculi biliferi C44.2 Auricula, NOS C69.5 Canaliculus lacrimalis C44.2 Auris externa C47.2 C47.8 Autonominen hermosto, alaraaja Autonominen hermosto, eri alueisiin ulottuva leesio Autonominen hermosto, hartia Autonominen hermosto, kasvot Autonominen hermosto, kaula Autonominen hermosto, lantio Autonominen hermosto, lonkka Autonominen hermosto, niska Autonominen hermosto, NOS Autonominen hermosto, pää Autonominen hermosto, rintakehä Autonominen hermosto, vartalo C21.1 C16.4 Canalis analis Canalis pyloricus C44.1 Canthus, NOS C25.0 Caput pancreatis C16.0 Cardia, NOS C34.0 Carina tracheae C32.3 C32.3 C32.3 C32.3 Cartilago arytaenoidea Cartilago cricoidea Cartilago cuneiformis Cartilago thyreoidea C32.1 C47.1 C47.0 C47.0 C47.5 C47.2 C47.0 C47.9 C47.0 C47.3 C47.6 B C 112 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C16.2 C25.1 C75.3 C71.0 C54.9 Corpus gastricum Corpus pancreatis Corpus pineale Corpus striatum Corpus uteri C71.0 C74.0 Cortex cerebri Cortex glandulae suprarenalis C41.3 Costa C68.0 Cowberin rauhanen C71.9 Cranial fossa, NOS Chiasma opticum C13.0 Cricoideus, NOS C11.3 Choana C16.6 C16.5 Curvatura major Curvatura minor C69.3 Chorioidea C10.4 C71.5 Cysta branchiogenes (kasvaimen sijaintipaikkana) C71.5 C71.5 Choroid plexus, kolmannen aivokammion Choroid plexus, neljännen aivokammion Choroid plexus, NOS Choroid plexus, sivukammion C41.3 Clavicula C51.2 Clitoris C18.2 C18.6 C18.7 C18.4 Colon ascendens Colon descendens Colon sigmoideum Colon transversum C44.3 Columella nasi C00.6 Commissura labiorum oris C44.2 C30.0 Concha auriculae Concha nasalis C69.0 Conjunctiva C72.0 Conus medullaris C69.1 Cornea, NOS C71.8 C69.4 Corpus callosum Corpus ciliare C72.1 C25.2 Cauda equina Cauda pancreatis C06.9 C30.1 Cavitas oris Cavitas tympani C30.0 Cavum nasi C71.6 Cerebellum C71.0 Cerebrum C53.9 C53.9 Cervix uteri Cervix, NOS C72.3 C71.7 D 113 C41.2 Discus intervertebralis C17.3 Diverticulum Meckel (kasvaimen sijaintipaikkana) C24.0 C24.0 C24.0 C24.0 C69.5 C25.3 C07.9 C08.1 C08.0 C49.3 Ductus biliaris, NOS Ductus choledochus Ductus cysticus Ductus hepaticus communis Ductus nasolacrimalis Ductus pancreatis Ductus parotideus Ductus sublinguales Ductus submandibularis Ductus thoracicus C17.0 Duodenum C70.0 C70.9 C70.1 Dura mater, kallon Dura mater, NOS Dura mater, selkäytimen Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) E C72.0 Filum terminale C52.9 Emätin, NOS C18.3 C18.5 Flexura hepatica Flexura lienalis C38.0 Endocardium C52.9 Fornix vaginae C53.0 Endocervix C75.9 Endokriininen rauhanen, NOS C54.1 Endometrium C48.1 C75.1 C76.3 C12.9 C49.0 C71.5 Ependyma C47.0 C71.5 Ependyymi C09.0 Fossa Douglasi Fossa hypophysialis Fossa ischiorectalis Fossa piriformis Fossa pterygoidea, side- tai pehmytkudos Fossa pterygoidea, ääreishermot tai autonominen hermosto Fossa tonsillaris C38.0 Epicardium C63.0 Epididymis C72.9 Epiduralis C00.4 C00.3 C02.2 C00.5 Frenulum labii inferioris Frenulum labii superioris Frenulum linguae Frenulum, huuli, NOS C10.1 Epiglottiksen etupinta C71.1 Frontaalilohko C32.1 Epiglottis, NOS (ei sisällä kurkunkannen etupintaa C10.1) C16.1 C54.3 C67.1 Fundus gastricus Fundus uteri Fundus vesicae C76.8 Epätarkasti määritellyn paikan eri alueisiin ulottuva leesio C63.1 Funiculus spermaticus C60.0 Esinahka C38.1 Etumediastinum C61.9 Eturauhanen C53.1 Exocervix G F C70.0 C70.0 C70.0 Falx cerebelli Falx cerebri Falx, NOS C10.9 Faux, NOS C40.2 Femur C40.2 Fibula 114 C47.9 Ganglia, NOS C52.9 Gartnerin tiehyt C16.9 Gaster, NOS C16.0 Gastroesofageaalinen junktio C03.1 C03.0 C03.9 Gingiva mandibularis Gingiva maxillaris Gingiva, NOS C44.2 C69.5 C50.9 C68.1 C07.9 C75.3 Glandula ceruminosa Glandula lacrimalis Glandula mammaria Glandula paraurethralis Glandula parotidea Glandula pinealis Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C75.1 C61.9 C63.7 C08.1 C08.0 C74.9 Glandula pituitaria Glandula prostatica Glandula seminalis Glandula sublingualis Glandula submandibularis Glandula suprarenalis C75.0 Glandulae parathyreoideae C60.1 Glans penis C75.5 C75.4 C75.5 C75.5 Glomus aorticum Glomus caroticum Glomus coccygeum Glomus jugulare C32.0 Glottis H C25.4 C25.8 C25.2 C25.7 C25.7 C25.9 C25.0 C25.1 C25.4 Haima, endokriininen Haima, eri alueisiin ulottuva leesio Haima, häntä Haima, kaula Haima, muu määritetty alue Haima, NOS Haima, pää Haima, runko Haima, umpirauhasosa C25.4 Haimasaarekkeet C25.3 Haimatiehyt C72.2 Hajuhermo C03.9 C03.9 Hammaskuoppa, limakalvo, NOS Hammaskuoppa, NOS C03.9 Hammaskuoppaharjanne, limakalvo, NOS C44.6 C76.4 C49.1 C47.1 C40.0 C47.1 Hartiapunos C44.2 Helix C42.4 Hematopoeettinen systeemi, NOS C39.9 Hengityselimet, sijainniltaan määrittämätön osa C39.8 Hengityselin ja muu rintaontelon elin, eri alueisiin ulottuva leesio C39.9 Hengitystiet, NOS C33.9 Henkitorvi C22.0 Hepar C47.9 Hermo, NOS C72.9 Hermosto, NOS C34.0 Hilum pulmonis C71.2 Hippocampus C40.0 Humerus C00.8 C44.0 C00.5 C00.9 C00.2 Huuli, eri alueisiin ulottuva leesio Huuli, iho, NOS Huuli, limakalvo, NOS Huuli, NOS (ei sisällä huulen ihoa C44.0) Huuli, punaosa, NOS Huuli, sisäpinta, NOS Huuli, suuontelo ja nielu, eri alueisiin ulottuva leesio Huuli, ulkopinta, NOS C52.9 Hymen C13.9 Hypopharynx, NOS C75.1 Hypophysis C71.0 Hypothalamus C41.4 Häntäluu C51.0 C51.0 C51.9 Häpyhuuli, iso Häpyhuuli, iso, iho Häpyhuuli, NOS C00.2 C00.5 C14.8 Hartia, iho Hartia, NOS Hartia, side- tai pehmytkudos Hartia, ääreishermot tai autonominen hermosto Hartiakaari 115 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C51.1 Häpyhuuli, pieni C51.2 Häpykieli C41.4 Häpyliitos C77.3 C77.0 C77.0 C77.1 C77.1 C77.1 C77.0 C77.5 C77.0 C77.0 I C03.9 Ien, NOS C44.7 C44.8 C44.0 C51.0 C44.3 C60.9 C44.4 C44.1 C44.2 C44.5 C51.9 C44.6 Iho, alaraaja tai lonkka Iho, eri alueisiin ulottuva leesio Iho, huuli, NOS Iho, iso häpyhuuli Iho, kasvojen muu tai määrittämätön osa Iho, kivespussi Iho, NOS (ei sisällä ison häpyhuulen ihoa C51.0, vulvan ihoa C51.9, peniksen ihoa C60.9, kivespussin ihoa C63.2) Iho, penis Iho, päälaki, kaula tai niska Iho, silmäluomi Iho, ulkokorva Iho, vartalo Iho, vulva Iho, yläraaja tai hartia C69.4 Iiris C18.0 Ileosekaaliläppä C17.2 Ileum (ei sisällä ileosekaaliläppää C18.0) C52.9 Immenkalvo C77.4 C77.9 C77.4 Imusolmuke, Cloquetin Imusolmuke, NOS Imusolmuke, Rosenmüllerin C77.0 C77.4 C77.8 C77.2 C77.0 Imusolmukkeet, alaleuan Imusolmukkeet, alaraajan Imusolmukkeet, eri alueiden Imusolmukkeet, haiman Imusolmukkeet, henkitorven etupuoliset Imusolmukkeet, henkitorven viereiset C63.2 C44.9 C77.1 C77.0 C77.1 C77.3 C77.5 C77.0 C77.0 C77.5 C77.2 C77.2 C77.2 C77.0 C77.0 C77.4 C77.3 C77.2 C77.1 C77.2 C77.5 C77.2 C77.4 C77.0 C77.1 C77.1 C77.5 C77.2 C77.3 C77.0 C77.2 C77.5 C77.2 C77.2 C77.1 C77.3 116 Imusolmukkeet, kainalon Imusolmukkeet, kasvojen Imusolmukkeet, kaulan Imusolmukkeet, keuhkojen Imusolmukkeet, keuhkoportin Imusolmukkeet, keuhkoputkien Imusolmukkeet, kielen Imusolmukkeet, kohdun viereiset Imusolmukkeet, korvantausImusolmukkeet, korvasylkirauhasen Imusolmukkeet, kurkunpään etupuoliset Imusolmukkeet, kylkiluuvälien Imusolmukkeet, kyynärtaipeen Imusolmukkeet, lantion Imusolmukkeet, leuanalaiset Imusolmukkeet, leuankärjenalaiset Imusolmukkeet, lonkan Imusolmukkeet, mahalaukun Imusolmukkeet, mahanportin Imusolmukkeet, maksan Imusolmukkeet, nieluntakaiset Imusolmukkeet, niskan Imusolmukkeet, nivusalueen Imusolmukkeet, olkavarren Imusolmukkeet, paksusuolen Imusolmukkeet, pallean Imusolmukkeet, para-aortaaliset Imusolmukkeet, peittyneen aukon kanavassa Imusolmukkeet, pernan Imusolmukkeet, polvitaipeen Imusolmukkeet, pään Imusolmukkeet, rintakehän Imusolmukkeet, rintalastan viereiset Imusolmukkeet, ristiluuvaltimoiden Imusolmukkeet, sisusvaltimorungon Imusolmukkeet, solisluun alaiset Imusolmukkeet, solisluun yläpuoliset Imusolmukkeet, suoliliepeen Imusolmukkeet, sydänalan alemmat Imusolmukkeet, vatsakalvontakaiset Imusolmukkeet, vatsan Imusolmukkeet, välikarsinan Imusolmukkeet, yläraajan Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C41.0 Kallo ja kasvon luut ja nivelrustot (ei sisällä alaleukaluuta C41.1) C41.2 Kannattajanikama C32.3 Kannurusto C75.4 Karotiskeränen Intra-abdominalis, NOS C30.1 Kartiolisäkkeen eteislokero C71.0 Isoaivokuori C41.0 C70.0 Isoaivosirppi C71.0 Isoaivot C54.0 Isthmus uteri C44.3 C77.0 C76.0 C49.0 C47.0 Kasvot ja kallon luut ja nivelrustot (ei sisällä alaleukaluuta C41.1) Kasvot, iho Kasvot, imusolmukkeet Kasvot, NOS Kasvot, side- tai pehmytkudos Kasvot, ääreishermot tai autonominen hermosto C41.4 Istuinluu C58.9 Istukka C76.1 Infraclavikulaarialue, NOS C71.0 Insula C25.4 Insulae pancreaticae C18.9 C17.9 Intestinum crassum, NOS Intestinum tenue, NOS C76.2 J C44.7 C40.2 C76.5 C49.2 C47.2 Jalka, iho Jalka, luu Jalka, NOS Jalka, side- tai pehmytkudos Jalka, ääreishermot tai autonominen hermosto C40.3 Jalkapöydän luu C17.1 Jejunum C16.0 Junctio oesophagogastrica C49.9 Jänne, NOS K C44.5 C77.3 C76.1 C49.3 C47.3 Kainalo, iho Kainalo, imusolmukkeet Kainalo, NOS Kainalo, side- tai pehmytkudos Kainalo, ääreishermot tai autonominen hermosto 117 C37.9 Kateenkorva C44.4 C77.0 C76.0 C49.0 C47.0 Kaula, iho Kaula, imusolmukkeet Kaula, NOS Kaula, side- tai pehmytkudos Kaula, ääreishermot tai autonominen hermosto C47.0 Kaulapunos C72.9 Keskushermosto C70.9 Keskushermostokalvot, NOS C71.0 Keskushermoston valkea aine C34.3 C34.3 C34.8 C34.2 C34.2 C34.9 C34.1 C34.1 Keuhko, alalohko Keuhko, alalohkon keuhkoputki Keuhko, eri alueisiin ulottuva leesio Keuhko, keskilohko Keuhko, keskilohkon keuhkoputki Keuhko, NOS Keuhko, ylälohko Keuhko, ylälohkon keuhkoputki C34.1 Keuhkonkieleke C34.0 Keuhkoportti Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C38.8 C38.4 Keuhkopussi, mediastinum ja sydän, eri alueisiin ulottuva leesio Keuhkopussi, NOS C34.9 C34.0 Keuhkoputki, NOS Keuhkoputki, Pää- C10.4 Kidustasku (kasvaimen sijaintipaikkana) C62.0 C62.1 C62.9 Kives, laskeutumaton (kasvaimen sijaintipaikkana) Kives, laskeutunut Kives, NOS C63.2 C63.2 Kivespussi, iho Kivespussi, NOS C21.2 Kloakogeeninen alue C53.0 C57.1 C57.4 Kohdun kaulakanavan sisäosa Kohdun leveä kannatin Kohdun sivuelimet C53.9 C53.8 Kohdunkaula Kohdunkaula, eri alueisiin ulottuva leesio C53.8 C53.8 Kohdunkaulan muuntumisalue Kohdunkaulan tynkä C53.1 Kohdunnapukka C54.3 Kohdunpohja C54.9 C54.8 C54.2 C54.1 Kohdunrunko Kohdunrunko, eri alueisiin ulottuva leesio Kohdunrunko, lihaskerros Kohdunrunko, limakalvo C54.0 Kohdunsola C08.1 C08.1 Kielenalussylkirauhanen Kielenalussylkirauhanen, tiehyet C02.2 C02.8 C02.3 C02.2 C02.0 C02.2 C02.3 C02.0 C02.1 C02.9 C02.1 C01.9 C01.9 C01.9 C01.9 C02.0 Kieli, alapinta, NOS Kieli, eri alueisiin ulottuva leesio Kieli, etuosa, NOS Kieli, etuosan alapinta, NOS Kieli, etuosan yläpinta Kieli, kahden etumaisen kolmanneksen alapinta Kieli, kahden etumaisen kolmanneksen yläpinta Kieli, kaksi etukolmannesta, NOS Kieli, keskiviiva Kieli, kärki Kieli, NOS Kieli, reuna Kieli, takakolmannes Kieli, takaosa, NOS Kieli, tyven yläpinta Kieli, tyvi, NOS Kieli, yläpinta, NOS C02.4 Kielirisa C53.1 Kohdunsuu C02.2 Kieliside C57.3 Kohdunvieruskudos C41.2 Kiertonikama C55.9 Kohtu, NOS C32.3 Kiilanmuotoinen rusto C57.2 Kohtu-nivusside C73.9 Kilpirauhanen C18.8 C32.3 Kilpirusto C18.6 C18.9 C09.1 Kitakaari C05.2 Kitakieleke C31.3 Kitaluun ontelo C11.1 Kitarisa Koolon, eri alueisiin ulottuva leesio Koolon, laskeva osa Koolon, NOS (ei sisällä peräsuoli, NOS C20.9 eikä rectosigmaa C19.9) Koolon, nouseva osa Koolon, oikea mutka Koolon, poikittainen osa Koolon, sigmasuoli Koolon, vasen mutka C02.0 C18.2 C18.3 C18.4 C18.7 C18.5 118 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C44.2 C49.0 Korva, NOS Korva, rustot C47.6 Kylki, ääreishermot tai autonominen hermosto C44.2 Korvakäytävä, NOS C41.3 Kylkiluu, rintalasta, solisluu ja nivelrustot C44.2 Korvalehti, NOS C41.3 Kylkiluu-poikkihaarakenivel C07.9 C07.9 Korvasylkirauhanen Korvasylkirauhanen, tiehyt C41.3 Kylkirusto C30.1 Korvatorvi C69.5 Kyynelkanava C70.0 C70.9 C70.1 C69.4 Kovakalvo, kallon Kovakalvo, NOS Kovakalvo, selkäytimen Kovakalvo, silmänvalkuainen C69.5 Kyynelpussi C69.5 Kyynelrauhanen C69.5 Kyyneltiehyt C75.2 Kraniofaryngeaalitiehyt C40.0 Kyynärnivel C44.6 C76.4 C49.1 C47.1 Kyynärpää, iho Kyynärpää, NOS Kyynärpää, side- tai pehmytkudos Kyynärpää, ääreishermot tai autonominen hermosto C40.1 Kämmen, luu C75.3 Käpyrauhanen C44.6 C40.0 C76.4 C49.1 C47.1 Käsi, iho Käsi, luu Käsi, NOS Käsi, side- tai pehmytkudos Käsi, ääreishermot tai autonominen hermosto C40.0 Käsivarsi, luu C44.3 Kulmakarva C14.0 Kurkku C10.0 Kurkunkannenkuoppa C10.1 C32.1 Kurkunkansi, etupinta Kurkunkansi, NOS (ei sisällä kurkunkannen etupintaa C10.1) Kurkunkansi, takapinta C32.1 C32.8 C32.9 C32.3 C32.0 C32.1 C32.2 C32.1 Kurkunpää, eri alueisiin ulottuva leesio Kurkunpää, eteispoimu, NOS (ei sisällä kurkunpään eteispoimun kurkunpään puoleista osaa C32.1) Kurkunpää, eteispoimun alanielun puoleinen osa Kurkunpää, eteispoimun kurkunpään puoleinen osa Kurkunpää, NOS Kurkunpää, rustot Kurkunpää, sisäosat Kurkunpää, ulko-osat Kurkunpää, ääniraon alapuolinen Kurkunpää, ääniraon yläpuolinen C72.4 Kuulo-tasapainohermo C44.5 C76.7 C49.6 Kylki, iho Kylki, NOS Kylki, side- tai pehmytkudos C13.1 C13.1 C32.1 L 119 C00.1 C51.0 C51.1 C00.0 C00.9 Labium inferius Labium majus pudendi Labium minus pudendi Labium superius Labium, NOS C25.4 Langerhansin saarekkeet C77.5 Lantio, imusolmukkeet Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C76.3 C49.5 C47.5 Lantio, NOS Lantio, side- tai pehmytkudos Lantio, ääreishermot tai autonominen hermosto C41.4 Lantion luut, ristiluu, häntäluu ja nivelrustot C40.0 Lapaluu C76.1 C49.3 Lapaluun alue, NOS Lapaluun alue, side- tai pehmytkudos Lapaluun alue, ääreishermot tai autonominen hermosto C47.3 C63.0 Lisäkives C74.9 Lisämunuainen, NOS C74.0 Lisämunuaiskuori C74.1 Lisämunuaisydin C44.7 C76.5 C49.2 C47.2 Lonkka, iho Lonkka, NOS Lonkka, side- tai pehmytkudos Lonkka, ääreishermot tai autonominen hermosto C41.4 Lonkkaluu C32.9 Larynx, NOS C41.4 Lonkkamalja C69.4 Lens crystallina C08.0 C08.0 Leuanalussylkirauhanen Leuanalussylkirauhanen, tiehyt C70.0 C70.9 C70.1 Lukinkalvo, kallon Lukinkalvo, NOS Lukinkalvo, selkäytimen C44.1 Luomi, NOS C44.3 C44.3 C49.0 C47.0 Leuka, iho Leuka, NOS Leuka, side- tai pehmytkudos Leuka, ääreishermot tai autonominen hermosto C41.1 C40.3 Luu, alaleukaluu Luu, alaraajan lyhyet luut ja niiden nivelet Luu, alaraajan pitkät luut ja niiden nivelet Luu, kallon ja kasvon luut ja nivelrustot (ei sisällä alaleukaluuta C41.1) Luu, kylkiluu, rintalasta, solisluu ja nivelrustot Luu, lantion luut, ristiluu, häntäluu ja nivelrustot Luu, nivel tai nivelrusto, eri alueisiin ulottuva leesio (Huom. Luiden, nivelten ja nivelrustojen kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C40 tai C41.) Luu, NOS Luu, raajan luu, NOS Luu, raajan luun, nivelen tai nivelruston eri alueisiin ulottuva leesio Luu, selkäranka (ei sisällä risti- ja häntäluuta C41.4) Luu, yläraajan lyhyet luut ja niiden nivelet Luu, yläraajan pitkät luut, lapaluu ja niiden nivelet C40.2 C76.0 Leukapieli, NOS C41.0 C41.1 C41.1 C41.0 Leukaluu, AlaLeukaluu, NOS Leukaluu, Ylä- C41.3 C41.1 Leukanivel C57.1 C57.3 C57.2 C57.3 C32.1 Ligamentum latum uteri Ligamentum rectouterinum Ligamentum rotundum uteri Ligamentum sacrouterinum Ligamentum vestibulare C49.9 Lihas, NOS C69.1 Limbus corneae C02.9 Lingua, NOS C34.1 Lingula pulmonis sinistri C75.0 Lisäkilpirauhanen C41.4 C41.8 C41.9 C40.9 C40.8 C41.2 C40.1 C40.0 120 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C38.8 C42.1 Luuydin C18.9 Lynkkysuoli M C44.5 Maha, iho C16.8 Mahalaukku, eri alueisiin ulottuva leesio Mahalaukku, etuseinä, NOS (ei luokiteltavissa C16.0-C16.4) Mahalaukku, iso kaarre, NOS (ei luokiteltavissa C16.0-C16.4) Mahalaukku, NOS Mahalaukku, pieni kaarre, NOS (ei luokiteltavissa C16.1-C16.4) Mahalaukku, takaseinä, NOS (ei luokiteltavissa C16.0-C16.4) C16.8 C16.6 C16.9 C16.5 C16.8 C16.1 Mahanpohjukka C16.3 Mahanportin soppi C16.4 Mahanportti C16.2 Mahanrunko C16.0 Mahansuu, NOS C22.0 Maksa C22.1 Maksansisäiset sappitiet C24.0 Maksanulkoiset sappitiet C50.0 Mamilla (ei sisällä rinnan ihoa C44.5) C41.1 Mandibula C41.0 Maxilla C17.3 Meckelin divertikkeli (kasvaimen sijaintipaikkana) Meckelin umpipussi (kasvaimen sijaintipaikkana) C17.3 C38.1 C38.3 Mediastinum, EtuMediastinum, NOS 121 C38.2 Mediastinum, sydän ja keuhkopussi, eri alueisiin ulottuva leesio Mediastinum, Taka- C74.1 C71.7 C72.0 Medulla glandulae suprarenalis Medulla oblongata Medulla spinalis C44.1 Meibomin rauhanen C58.9 Membrana fetalis C40.2 Meniscus C48.1 Mesenterium C48.1 Mesoappendix C48.1 Mesocolon C10.9 Mesopharynx, NOS C40.1 Metakarpaaliluu C40.3 Metatarsaaliluu C06.0 Mucosa buccalis C57.0 Munanjohdin C56.9 Munasarja C64.9 Munuainen, NOS C65.9 Munuaisallas C49.3 Musculi intercostales C49.1 C49.2 C49.1 C49.1 C49.1 C49.2 C49.5 C49.4 C49.3 C49.0 C49.3 C49.4 C49.2 Musculus biceps brachii Musculus biceps femoris Musculus brachialis Musculus coracobrachialis Musculus deltoideus Musculus gastrocnemius Musculus gluteus maximus Musculus iliopsoas Musculus latissimus dorsi Musculus masseter Musculus pectoralis major Musculus psoas Musculus quadriceps femoris Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C49.4 C21.1 C49.0 C49.3 C49.1 Musculus rectus abdominis Musculus sphincter ani Musculus sternocleidomastoideus Musculus trapezius Musculus triceps brachii C69.4 Mykiö C38.0 Myocardium C54.2 Myometrium N C44.3 Nenänsiiveke C30.0 Nenäontelo (ei sisällä nenä, NOS C76.0) C72.5 C72.5 C72.5 C47.2 C72.5 C72.5 C47.3 C47.2 C47.6 C47.1 C47.2 C72.5 C72.2 C72.3 C47.1 C47.5 C72.5 C72.5 C47.1 C72.5 C72.4 Nervus abducens Nervus accessorius, NOS Nervus facialis Nervus femoralis Nervus glossopharyngeus Nervus hypoglossus Nervus intercostalis Nervus ischiadicus Nervus lumbalis Nervus medianus Nervus obturatorius Nervus oculomotorius Nervus olfactorius Nervus opticus Nervus radialis Nervus sacralis Nervus trigeminus Nervus trochlearis Nervus ulnaris Nervus vagus Nervus vestibulocochlearis C14.0 C14.2 C14.0 C14.8 Nielu, NOS Nielu, risarengas Nielu, seinä, NOS Nielu, suuontelo ja huuli, eri alueisiin ulottuva leesio C09.8 Nielurisa, eri alueisiin ulottuva leesio Nielurisa, NOS (ei sisällä kielirisaa C02.4 ja kitarisaa C11.1) C53.0 Nabothin rauhanen C44.5 C49.4 C47.4 Napa, NOS Napa, side- tai pehmytkudos Napa, ääreishermot tai autonominen hermosto C11.9 Nasopharynx, NOS C30.0 C44.3 C30.0 C76.0 C30.0 C31.9 C31.8 C11.3 Nenä, eteinen Nenä, iho Nenä, limakalvo Nenä, NOS Nenä, rustot Nenä, sivuontelo, NOS Nenä, sivuontelot, eri alueisiin ulottuva leesio Nenä, väliseinä, NOS (ei sisällä nenän väliseinän takareunusta C11.3) Nenä, väliseinän takareunus C30.0 Nenäkuorikko C09.0 Nielurisakuoppa C11.8 C41.2 Nikama C11.3 C11.0 C11.9 C11.9 C11.2 C11.1 Nenänielu, eri alueisiin ulottuva leesio Nenänielu, etuseinä Nenänielu, katto Nenänielu, NOS Nenänielu, seinä Nenänielu, sivuseinä Nenänielu, takaseinä C41.2 Nikamavälilevy C44.7 C76.5 C49.2 C47.2 C11.3 Nenä-nieluaukko Nilkka, iho Nilkka, NOS Nilkka, side- tai pehmytkudos Nilkka, ääreishermot tai autonominen hermosto C11.3 Nenänielupinta, pehmeän suulaen C40.3 Nilkkaluut C30.0 C09.9 122 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C40.3 Nilkkanivel C44.4 C77.0 C76.0 C49.0 C47.0 Niska, iho Niska, imusolmukkeet Niska, NOS Niska, side- tai pehmytkudos Niska, ääreishermot tai autonominen hermosto C41.8 C41.9 Nivel, luu tai nivelrusto, eri alueisiin ulottuva leesio (Huom. Luiden, nivelten ja nivelrustojen kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C40 tai C41.) Nivel, NOS C40.2 Nivelkierukka C41.8 Nivelrusto, luu tai nivel, eri alueisiin ulottuva leesio (Huom. Luiden, nivelten ja nivelrustojen kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C40 tai C41.) C44.5 C77.4 C76.3 C49.5 C47.5 Nivusalue, iho Nivusalue, imusolmukkeet Nivusalue, NOS Nivusalue, side- tai pehmytkudos Nivusalue, ääreishermot tai autonominen hermosto C77.0 C77.2 C77.3 C77.3 C77.1 C77.2 C77.2 C77.3 C77.5 C77.2 C77.2 C77.1 C77.2 C77.5 C77.3 C77.4 C77.1 C77.0 C77.2 Nodi cervicales Nodi lymphatici abdominis Nodi lymphatici axillares Nodi lymphatici brachiales Nodi lymphatici bronchopulmonales Nodi lymphatici coeliaci Nodi lymphatici colici Nodi lymphatici cubitales Nodi lymphatici epigastici inferiores Nodi lymphatici gastrici Nodi lymphatici hepatici Nodi lymphatici hilares Nodi lymphatici ileocolici Nodi lymphatici iliaci Nodi lymphatici infraclaviculares Nodi lymphatici inguinales Nodi lymphatici intercostales Nodi lymphatici linguales Nodi lymphatici lumbales C77.1 C77.2 C77.5 C77.0 C77.2 C77.1 C77.1 C77.5 C77.0 C77.2 C77.1 C77.4 C77.1 C77.2 C77.0 C77.2 C77.5 C77.2 C77.0 C77.0 C77.0 C77.1 C77.0 C77.0 C77.0 Nodi lymphatici mediastinales Nodi lymphatici mesenterici Nodi lymphatici obturatori Nodi lymphatici occipitales Nodi lymphatici pancreatici Nodi lymphatici parasternales Nodi lymphatici paratracheales Nodi lymphatici parauterini Nodi lymphatici parotidei Nodi lymphatici periaortici Nodi lymphatici phrenici Nodi lymphatici poplitei Nodi lymphatici pulmonales Nodi lymphatici pylorici Nodi lymphatici retroauriculares Nodi lymphatici retroperitoneales Nodi lymphatici sacrales Nodi lymphatici splenici Nodi lymphatici submandibulares Nodi lymphatici submentales Nodi lymphatici supraclaviculares Nodi lymphatici thoracis Nodi prelaryngei Nodi pretracheales Nodi retrophanryngeales C77.0 Nodus mandibularis C72.3 Näköhermo C50.0 Nänni (ei sisällä rinnan ihoa C44.5) O 123 C15.9 Oesophagus, NOS C44.3 C49.0 C47.0 Ohimo, NOS Ohimo, side- tai pehmytkudos Ohimo, ääreishermot tai autonominen hermosto C71.2 Ohimolohko C17.8 C17.9 Ohutsuoli, eri alueisiin ulottuva leesio Ohutsuoli, NOS C71.4 Oksipitaalilohko C71.7 Oliva Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C40.0 Olkalisäke-solisluunivel C31.2 Otsaontelo C40.0 Olkanivel C56.9 Ovario C44.6 C76.4 C49.1 C47.1 Olkapää, iho Olkapää, NOS Olkapää, side- tai pehmytkudos Olkapää, ääreishermot tai autonominen hermosto C48.1 Omentti C71.0 Operculum C69.6 C69.6 C69.6 C69.6 Orbita, autonominen hermosto Orbita, NOS Orbita, sidekudos Orbita, ääreishermo C10.9 Oropharynx, NOS C41.4 C41.4 C41.0 C41.0 C41.0 C41.4 C41.4 C40.1 C41.0 C41.0 C41.0 C41.4 C41.0 C41.0 C41.0 Os coccygis Os coxae Os ethmoidale Os frontale Os hyoideum Os ilium Os ischii Os metacarpale Os nasale Os occipitale Os parietale Os sacrum Os sphenoidale Os temporale Os zygomaticum C40.1 C40.3 Ossa carpi Ossa tarsalia C16.0 C67.6 C67.5 C53.1 Ostium cardiacum Ostium ureteris Ostium urethrae internum Ostium uteri C44.3 C44.3 C49.0 C47.0 Otsa, iho Otsa, NOS Otsa, side- tai pehmytkudos Otsa, ääreishermot tai autonominen hermosto C71.1 P Otsalohko 124 C44.5 C76.3 C49.5 C47.5 Pakara, iho Pakara, NOS Pakara, side- tai pehmytkudos Pakara, ääreishermot tai autonominen hermosto C18.9 Paksusuoli, NOS (ei sisällä peräsuoli, NOS C20.9 eikä rectosigmaa C19.9) C05.0 C05.1 C05.9 Palatum durum Palatum molle Palatum, NOS C49.3 Pallea C71.0 Pallium C25.9 Pancreas, NOS C24.1 Papilla Vateri C75.5 Paraganglio C57.3 Parametrium C72.9 Parasellaris C47.9 Parasympaattinen hermosto, NOS C71.3 Parietaalilohko C07.9 Parotis, NOS C40.3 Patella C71.7 Pedunculus cerebri C70.0 C70.9 C70.1 Pehmeä kalvo, kallon Pehmeä kalvo, NOS Pehmeä kalvo, selkäytimen C49.2 Pehmytkudos, alaraaja Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C21.0 C49.6 C49.4 C49.1 Pehmytkudos, eri alueisiin ulottuva leesio Pehmytkudos, hartia Pehmytkudos, kasvot Pehmytkudos, kaula Pehmytkudos, lantio Pehmytkudos, lonkka Pehmytkudos, niska Pehmytkudos, NOS Pehmytkudos, pää (ei sisällä orbitan C69.6 sidekudoksia, eikä nenän rustoja C30.0) Pehmytkudos, rintakehä (ei sisällä kateenkorvaa C37.9, sydäntä ja mediastinumia C38._) Pehmytkudos, vartalo Pehmytkudos, vatsa Pehmytkudos, yläraaja C65.9 C76.3 C49.8 C49.1 C49.0 C49.0 C49.5 C49.2 C49.0 C49.9 C49.0 C21.8 Peräaukko, NOS (ei sisällä anuksen ihoa ja perianaalista ihoa C44.5) Peräaukko, peräsuoli ja peräaukkokanava, eri alueisiin ulottuva leesio C21.1 C21.8 Peräaukkokanava Peräaukkokanava, peräaukko ja peräsuoli, eri alueisiin ulottuva leesio C20.9 C21.8 Peräsuoli, NOS Peräsuoli, peräaukko ja peräaukkokanava, eri alueisiin ulottuva leesio C57.3 Peräsuoli-kohtuside Pelvis renalis Pelvis, NOS C40.1 C40.3 Phalanges manus Phalanges pedis C60.8 C60.0 C60.9 C60.9 C60.2 C60.1 Penis, eri alueisiin ulottuva leesio Penis, esinahka Penis, iho Penis, NOS Penis, runko Penis, terska C14.0 Pharynx, NOS C70.0 C70.9 C70.1 Pia mater, kallon Pia mater, NOS Pia mater, selkäytimen C70.0 Pikkuaivosirppi C48.0 Periadrenaalinen kudos C71.6 Pikkuaivot, NOS C70.0 Pikkuaivoteltta C44.2 Pinna auris C58.9 Placenta C38.4 C38.4 C38.4 C38.8 Pleura parietalis Pleura visceralis Pleura, NOS Pleura, mediastinum ja sydän, eri alueisiin ulottuva leesio C47.1 C47.0 C47.5 C47.5 Plexus brachialis Plexus cervicalis Plexus lumbosacralis Plexus sacralis C32.1 C32.0 Plica vestibularis Plica vocalis C49.3 C44.5 Perianaalinen iho C38.0 Pericardium C44.5 C76.3 C49.5 C47.5 Perineum, iho Perineum, NOS Perineum, side- tai pehmytkudos Perineum, ääreishermot tai autonominen hermosto C48.0 Peripankreaattinen kudos C76.3 Perirectaalialue, NOS C48.0 Perirenaalinen kudos C48.8 C48.2 Peritoneum ja retroperitoneum, eri alueisiin ulottuva leesio Peritoneum, NOS C42.2 Perna 125 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C17.0 Pohjukaissuoli C44.7 C76.5 C49.2 C47.2 Polvi, iho Polvi, NOS Polvi, side- tai pehmytkudos Polvi, ääreishermot tai autonominen hermosto C40.3 Polvilumpio C40.2 Polvinivel, NOS C71.7 Pons C53.1 Portio C44.3 C06.0 C76.0 C49.0 C06.0 C47.0 Poski, iho Poski, limakalvo Poski, NOS Poski, side- tai pehmytkudos Poski, sisäpuoli Poski, ääreishermot tai autonominen hermosto C06.2 Poskihammas, taka-alue C31.0 Poskiontelo C60.0 Preputium C61.9 Prostata, NOS C71.0 Putamen C16.4 Pylorus C71.7 Pyramis medullae oblongatae C44.4 C77.0 C76.0 C49.0 Pää, iho, NOS Pää, imusolmukkeet Pää, NOS Pää, side- tai pehmytkudos (ei sisällä orbitan C69.6 sidekudoksia, eikä nenän rustoja C30.0) Pää, ääreishermot tai autonominen hermosto C47.0 C34.0 Pääbronchus C41.0 Pääkallo, NOS C34.0 Pääkeuhkoputki C44.4 C49.0 C47.0 Päälaki, iho Päälaki, side- tai pehmytkudos Päälaki, ääreishermot tai autonominen hermosto C71.3 Päälakilohko R C40.9 C40.8 126 C40.9 C40.9 Raaja, luu, NOS Raaja, luun, nivelen tai nivelruston eri alueisiin ulottuva leesio Raaja, nivel, NOS Raaja, nivelrusto, NOS C40.0 Radius C63.7 Rakkularauhanen C44.6 C76.4 C49.1 C47.1 Ranne, iho Ranne, NOS Ranne, side- tai pehmytkudos Ranne, ääreishermot tai autonominen hermosto C40.1 Ranneluut C40.1 Rannenivel C49.9 Rasvakudos, NOS C75.1 Rathken pussi C11.2 C12.9 Recessus pharyngeus Recessus piriformis C19.9 Rectosigma C20.9 Rectum, NOS C64.9 Ren, NOS C32.3 Rengasrusto C13.0 Rengasrustontakainen alue C42.3 Retikuloendoteliaalisysteemi, NOS C69.2 Retina Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C48.0 Retroperitoneaalinen kudos C41.4 Ristiluu C48.0 C48.8 Retroperitoneum Retroperitoneum ja peritoneum, eri alueisiin ulottuva leesio C47.5 Ristipunos C49.5 C47.5 Ristiselkä, side- tai pehmytkudos Ristiselkä, ääreishermot tai autonominen hermosto C76.3 Ristiselän alue, NOS C11.2 Rosenmüllerin kuoppa C15.5 C15.8 C15.0 C15.4 C15.9 C15.1 C15.2 C15.3 Ruokatorvi, alakolmannes Ruokatorvi, eri alueisiin ulottuva leesio Ruokatorvi, kaulaosa Ruokatorvi, keskikolmannes Ruokatorvi, NOS Ruokatorvi, rintakehäosa Ruokatorvi, vatsaosa Ruokatorvi, yläkolmannes C41.9 Rusto, NOS C26.8 C26.9 Ruuansulatuselimet, eri alueisiin ulottuva leesio (Huom. ruuansulatuselinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C15-C26.0.) Ruuansulatuselimet, NOS C26.9 Ruuansulatuselimistö, NOS C26.9 Ruuansulatuskanava, NOS C48.0 Retrosekaalinen kudos C50.8 Rinta, alaosa (ei sisällä rinnan ihoa C44.5) Rinta, alasisäneljännes (ei sisällä rinnan ihoa C44.5) Rinta, alasivuneljännes (ei sisällä rinnan ihoa C44.5) Rinta, eri alueisiin ulottuva leesio (ei sisällä rinnan ihoa C44.5) Rinta, kainaloon suuntautuva osa (ei sisällä rinnan ihoa C44.5) Rinta, keskiosa (ei sisällä rinnan ihoa C44.5) Rinta, keskiviiva (ei sisällä rinnan ihoa C44.5) Rinta, NOS (ei sisällä rinnan ihoa C44.5) Rinta, nänni Rinta, sivu (ei sisällä rinnan ihoa C44.5) Rinta, yläosa (ei sisällä rinnan ihoa C44.5) Rinta, yläsisäneljännes (ei sisällä rinnan ihoa C44.5) Rinta, yläsivuneljännes (ei sisällä rinnan ihoa C44.5) C50.3 C50.5 C50.8 C50.6 C50.1 C50.8 C50.9 C50.0 C50.8 C50.8 C50.2 C50.4 C44.5 C77.1 C76.1 C49.3 C47.3 Rintakehä, iho Rintakehä, imusolmukkeet Rintakehä, NOS Rintakehä, side- tai pehmytkudos (ei sisällä kateenkorvaa C37.9, sydäntä ja mediastinumia C38._) Rintakehä, ääreishermot tai autonominen hermosto S C69.5 Saccus lacrimalis C25.3 Santorinin tiehyt C41.3 Rintalasta C23.9 Sappirakko C41.3 Rintalasta-kylkiluunivel C24.0 Sappitiehyt, NOS C76.1 Rintaontelo, NOS C24.8 C39.8 Rintaontelon elin ja hengityselin, eri alueisiin ulottuva leesio Sappitiet, eri alueisiin ulottuva leesio (Huom. Kasvain, joka kasvaa sekä maksansisäisissä että maksanulkoisissa sappiteissä) Sappitiet, maksansisäiset C22.1 127 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C24.0 C24.9 Sappitiet, maksanulkoiset Sappitiet, NOS C49.3 C69.1 Sarveiskalvo, NOS C40.0 Scapula C49.6 C49.4 C49.1 Sidekudos, rintakehä (ei sisällä kateenkorvaa C37.9, sydäntä ja mediastinumia C38._) Sidekudos, vartalo Sidekudos, vatsa Sidekudos, yläraaja C69.4 Sclera C63.1 Siemenjohdin C63.2 Scrotum, NOS C63.1 Siemennuora C44.5 C76.7 C49.6 C47.6 Selkä, iho Selkä, NOS Selkä, side- tai pehmytkudos Selkä, ääreishermot tai autonominen hermosto C30.0 Sierain C18.7 Sigmasuoli C60.2 Siitin, runko C41.2 Selkäranka (ei sisällä risti- ja häntäluuta C41.4) C58.9 Sikiökalvot C69.8 C72.0 Selkäydin C47.9 Selkäydinhermo, NOS C70.1 Selkäydinkalvot C72.1 Selkäytimen häntä C69.4 C69.9 C69.1 C69.0 C69.3 C69.4 C69.2 Silmä tai sen apuelin, eri alueisiin ulottuva leesio Silmä, kovakalvo Silmä, NOS Silmä, sarveiskalvo Silmä, sidekalvo Silmä, suonikalvo Silmä, sädekehä Silmä, verkkokalvo C75.1 Sella turcica C44.1 Silmäkulma, NOS C30.0 C69.6 Silmäkuoppa, NOS C57.9 Septum nasi, NOS (ei sisällä nenän väliseinän takareunusta C11.3) Septum urethrovaginale C44.1 Silmäluomi C31.1 Seulalokerosto C69.4 Silmämuna C69.0 Sidekalvo C31.1 C31.2 C31.0 C31.3 Sinus ethmoidalis Sinus frontalis Sinus maxillaris Sinus sphenoidalis C30.1 Sisäkorva C31.9 Sivuontelo, NOS C41.3 Solisluu C76.1 C49.3 Solisluun alapuolen alue, NOS Solisluun alapuolen side- tai pehmytkudos C49.2 C49.8 C49.1 C49.0 C49.0 C49.5 C49.2 C49.0 C49.9 C49.0 Sidekudos, alaraaja Sidekudos, eri alueisiin ulottuva leesio Sidekudos, hartia Sidekudos, kasvot Sidekudos, kaula Sidekudos, lantio Sidekudos, lonkka Sidekudos, niska Sidekudos, NOS Sidekudos, pää (ei sisällä orbitan C69.6 sidekudoksia, eikä nenän rustoja C30.0) 128 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C47.3 C76.0 C44.4 C49.0 C47.0 C44.6 C44.6 C40.1 C76.4 C49.1 C47.1 C24.0 Solisluun alapuolen ääreishermot tai autonominen hermosto Solisluun yläpuolen alue, NOS Solisluun yläpuolen iho Solisluun yläpuolen side- tai pehmytkudos Solisluun yläpuolen ääreishermot tai autonominen hermosto C69.4 Suonikalvosto C44.4 C76.0 Supraclaviculaarialue, iho Supraclavikulaarialue, NOS C32.1 Supraglotticus C06.8 Sormi, iho Sormi, kynsi Sormi, luu Sormi, NOS Sormi, side- tai pehmytkudos Sormi, ääreishermot tai autonominen hermosto C06.1 C06.9 C06.9 Suu, eri alueisiin ulottuva muu tai määrittämätön osan leesio Suu, eteinen Suu, limakalvo Suu, NOS C05.8 C05.0 C05.8 Sphincter Oddi C05.9 C05.1 C07.9 Stensenin tiehyt C41.3 Sternum C32.2 Subglotticus C10.8 C63.8 C10.9 C10.2 C10.3 C57.9 Sukuelimet, miehen, eri alueisiin ulottuva leesio (Huom. miehen sukuelinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C60-C63.7.) Sukuelimet, miehen, muu määritetty osa Sukuelimet, miehen, NOS Sukuelimet, naisen, eri alueisiin ulottuva leesio (sukuelinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C51-C57.7 tai C58) Sukuelimet, naisen, muu määritetty osa Sukuelimet, naisen, NOS C26.0 Suoli, NOS C63.7 C63.9 C57.8 C57.7 C04.8 C04.0 C04.9 C04.1 Suulaki, eri alueisiin ulottuva leesio Suulaki, kova Suulaki, kovan ja pehmeän suulaen rajakohta Suulaki, NOS Suulaki, pehmeä, NOS (ei sisällä pehmeän suulaen nenänielupintaa C11.3) Suunielu, eri alueisiin ulottuva leesio Suunielu, NOS Suunielu, sivuseinä Suunielu, takaseinä Suunpohja, eri alueisiin ulottuva leesio Suunpohja, etuosa Suunpohja, NOS Suunpohja, sivuosa C06.9 C14.8 Suuontelo Suuontelo, huuli ja nielu, eri alueisiin ulottuva leesio C00.6 Suupieli C38.0 Sydämen sisäkalvo C38.0 C38.8 Sydän Sydän, mediastinum ja keuhkopussi, eri alueisiin ulottuva leesio C26.0 Suolikanava, NOS C48.1 Suolilieve C41.4 Suoliluu C38.0 Sydäneteinen C26.0 Suolisto, NOS C38.0 Sydänkammio 129 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C02.4 C11.1 Tonsilla lingualis Tonsilla pharyngealis C09.9 Tonsillae palatinae C33.9 Trachea C26.9 C26.0 C72.3 C39.9 Tractus digestorius, NOS Tractus intestinalis, NOS Tractus opticus Tractus respiratorius, NOS C44.2 Tragus Sympaattinen hermosto, NOS C06.2 C67.0 Trigonum retromolare Trigonum vesicae Symphysis pubica C49.4 Truncus coeliacus C30.1 C57.0 Tuba auditiva Tuba uterina C38.0 Sydänlihas C38.0 Sydänpussi C17.2 Sykkyräsuoli C08.9 C08.9 Sylkirauhanen, NOS (ei sisällä pieni sylkirauhanen, NOS C06.9; katso huomautus C08:n alta ) Sylkirauhanen, pieni, NOS (katso huomautus C08:n alta) Sylkirauhanen, suuri, eri alueisiin ulottuva leesio Sylkirauhanen, suuri, NOS C47.9 C41.4 C06.9 C08.8 T C38.2 Takamediastinum C63.7 C69.4 Tunica vaginalis Tunica vasculosa bulbi C71.4 Takaraivolohko C80.9 Tuntematon sijaintipaikka C71.8 Tapetum C17.1 Tyhjäsuoli C32.1 Taskuhuuli C71.0 Tyvitumake C32.1 Taskujänne C30.1 Täryontelo C71.2 Temporaalilohko C70.0 Tentorium cerebelli C60.1 Terska C44.2 Ulkokorva C62.0 C51.9 Ulkosynnyttimet, NOS C62.9 Testis ectopicus (kasvaimen sijaintipaikkana) Testis, NOS C40.0 Ulna C71.0 Thalamus C44.5 Umbilicus, NOS C76.1 Thorax, NOS C18.1 Umpilisäke C37.9 Thymus C75.8 C73.9 Thyreoidea C75.9 C75.8 C40.2 Tibia Umpirauhanen tai sen kaltainen elin, eri alueisiin ulottuva leesio Umpirauhanen, NOS Umpirauhanen, useiden umpirauhasten leesio U 130 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C18.0 Umpisuoli C48.8 C71.2 Uncus C48.2 Vatsakalvo ja sen takainen tila, eri alueisiin ulottuva leesio Vatsakalvo, NOS C67.7 Urakus C48.1 Vatsakalvon määritetty osa C66.9 Ureter C48.2 Vatsakalvonontelo C68.0 Urethra C48.0 Vatsakalvontakaisen tilan kudos C55.9 Uterus, NOS C49.4 Vatsalihakset C68.0 Utriculus prostaticus C76.2 C49.4 C69.4 Uvea C05.2 Uvula palatina Vatsanpeitteet, NOS Vatsanpeitteet, side- tai pehmytkudos Vatsanpeitteet, ääreishermot tai autonominen hermosto C47.4 V C52.9 Vagina, NOS C14.2 Waldeyerin nielurengas C10.0 Vallecula epiglottica C44.5 C76.7 C49.6 C47.6 Vartalo, iho Vartalo, NOS Vartalo, side- tai pehmytkudos Vartalo, ääreishermot tai autonominen hermosto C44.7 C44.7 C40.3 C76.5 C49.2 C47.2 Varvas, iho Varvas, kynsi Varvas, luu Varvas, NOS Varvas, side- tai pehmytkudos Varvas, ääreishermot tai autonominen hermosto C63.1 Vas deferens C44.5 C77.2 C76.2 C49.4 C47.4 Vatsa, iho Vatsa, imusolmukkeet Vatsa, NOS Vatsa, side- tai pehmytkudos Vatsa, ääreishermot tai autonominen hermosto 131 C76.2 Vatsaontelo C18.7 Vemmelsuoli C49.4 C49.3 C49.4 C49.5 Vena cava inferior Vena cava superior Vena cava, NOS Vena iliaca C38.0 C71.5 C71.7 C71.5 C16.9 Ventriculus cordis Ventriculus lateralis, NOS Ventriculus quartus, NOS Ventriculus tertius, NOS Ventriculus, NOS C42.0 Veri C49.9 Verisuoni, NOS C69.2 Verkkokalvo C71.6 Vermis cerebelli C41.2 Vertebra C23.9 C23.9 C67.9 Vesica biliaris Vesica fellea Vesica urinaria, NOS C57.9 Vesicocervikaalinen kudos C30.0 Vestibuli nasi C06.1 Vestibulum oris Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C44.0 C00.3 C00.0 C00.0 C00.3 C00.0 Ylähuuli, iho Ylähuuli, limakalvo Ylähuuli, NOS (ei sisällä ylähuulen ihoa C44.0) Ylähuuli, punaosa Ylähuuli, sisäpinta Ylähuuli, ulkopinta C03.0 Yläien C03.0 Yläleuka, hammaskuopan limakalvo Yläleuka, hammaskuoppa Yläleuka, hammaskuoppaharjanteen limakalvo C08.0 Whartonin tiehyt C25.3 Wirsungin tiehyt C68.8 Virtsaelin, eri alueisiin ulottuva leesio (Huom. virtsaelinten kasvain, jonka syntypaikkaa ei voi määritellä luokkiin C64-C68.1.) C66.9 C67.6 Virtsanjohdin Virtsanjohdin, aukko C68.0 C67.5 C68.1 Virtsaputki Virtsaputki, sisäsuu Virtsaputki, vierusrauhaset C03.0 C03.0 C67.8 C41.0 Yläleukaluu C67.3 C67.5 C67.0 C67.9 C67.1 C67.2 C67.4 Virtsarakko, eri alueisiin ulottuva leesio Virtsarakko, etuseinä Virtsarakko, kaula Virtsarakko, kolmio Virtsarakko, NOS Virtsarakko, pohja Virtsarakko, sivuseinä Virtsarakko, takaseinä C44.6 C77.3 C40.0 C40.1 C68.9 Virtsatiet, NOS C49.1 C47.1 C57.7 Wolffin tiehyt Yläraaja, iho Yläraaja, imusolmukkeet Yläraaja, luu Yläraaja, lyhyet luut ja niiden nivelet Yläraaja, NOS Yläraaja, pitkät luut ja niiden nivelet Yläraaja, side- tai pehmytkudos Yläraaja, ääreishermot tai autonominen hermosto C51.8 C51.9 C51.9 Vulva, eri alueisiin ulottuva leesio Vulva, iho Vulva, NOS C38.1 C38.3 C38.8 C38.2 Välikarsina, etuosa Välikarsina, NOS Välikarsina, sydän ja keuhkopussi, eri alueisiin ulottuva leesio Välikarsina, takaosa C30.1 Välikorva C69.4 Värikalvo C76.4 C40.0 Z C75.5 Ä Y C71.7 Ydinjatke C39.0 Ylähengitystiet, NOS Zuckerkandlin elin C32.0 Äänielin C32.0 Äänihuuli, NOS C32.0 Äänirako C47.2 C47.8 Ääreishermo, alaraaja Ääreishermo, eri alueisiin ulottuva leesio Ääreishermo, hartia Ääreishermo, kasvot C47.1 C47.0 132 Anatomisten sijaintipaikkojen aakkosellinen hakemisto (jatkuu) C47.0 C47.5 C47.2 C47.0 C47.9 C47.0 C47.3 C47.6 C47.4 C47.1 Ääreishermo, kaula Ääreishermo, lantio Ääreishermo, lonkka Ääreishermo, niska Ääreishermo, NOS Ääreishermo, pää Ääreishermo, rintakehä Ääreishermo, vartalo Ääreishermo, vatsa Ääreishermo, yläraaja 133 ALPHABETIC INDEX NOS - Not Otherwise Specified A C76.2 C47.4 C49.4 C49.4 C47.4 C44.5 C49.4 M-8730/0 Achromic nevus (C44._) Abdomen NOS autonomic nervous system connective tissue muscle peripheral nerve skin subcutaneous tissue M-8280/3 M-8280/0 M-8280/3 M-8281/0 Acidophil-basophil adenoma, mixed (C75.1) M-8281/3 Acidophil-basophil carcinoma, mixed (C75.1) M-8822/1 Abdominal desmoid M-8822/1 Abdominal fibromatosis C49.4 C15.2 C77.2 C49.4 Abdominal aorta esophagus lymph node vena cava C76.2 C44.5 C49.4 C49.4 C47.4 C49.4 C49.4 C49.4 C49.4 C47.4 C49.4 C44.5 C49.4 C49.4 Abdominal wall NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C72.5 Abducens nerve M-8550/3 M-8550/0 M-8550/3 M-8550/0 M-8550/3 M-8551/3 M-8550/1 Acinar cell adenoma carcinoma cystadenocarcinoma tumor [obs] M-8550/3 M-8550/0 M-8550/1 Acinic cell adenocarcinoma adenoma tumor [obs] C72.4 Acoustic nerve M-9560/0 Acoustic neuroma (C72.4) M-9161/0 Acquired tufted hemangioma M-8744/3 Acral lentiginous melanoma, malignant (C44._) C40.0 Acromioclavicular joint M-8402/0 Acrospiroma, eccrine (C44._) M--------- Actinic keratosis (see SNOMED) Acute erythremia (C42.1) [obs] erythremic myelosis (C42.1) [obs] myelofibrosis (C42.1) myelosclerosis, NOS (C42.1) panmyelosis, NOS (C42.1) [obs] panmyelosis with myelofibrosis (C42.1) M-9754/3 progressive histiocytosis X M-9840/3 M-9840/3 M-9931/3 M-9931/3 M-9931/3 M-9931/3 Accessory nasal sinus nerve, NOS nerve, spinal sinus, NOS sinus, nasal Adamantinoma NOS (except of long bones M-9261/3) (C41._) M-9261/3 long bones (C40._) M-9310/0 C41.4 Acinar adenocarcinoma adenoma carcinoma M-8154/3 Acinar-endocrine carcinoma, mixed (C25._) M-9871/3 Abnormal marrow eosinophils, acute myeloid leukemia with (includes al variants) M-9871/3 Abnormal marrow eosinophils, acute myelomonocytic leukemia with (includes all variants) M-8075/3 Acantholytic squamous cell carcinoma M--------- Acanthoma, clear cell (see SNOMED) M--------- Acanthosis nigricans (see SNOMED) C31.9 C72.5 C72.5 C31.9 C31.9 Acidophil adenocarcinoma (C75.1) adenoma (C75.1) carcinoma (C75.1) Acetabulum 134 Alphabetic Index M-9310/3 M-9261/3 Adamantinoma, continued malignant (except of long bones M-9261/3) (C41._) tibial (C40.2) M-9351/1 Adamantinomatous craniopharyngioma (C75.2) M-8570/3 Adenoacanthoma M-9300/0 Adenoameloblastoma (C41._) M-8313/3 M-9015/3 M-9014/3 Adenocarcinofibroma clear cell (C56.9) mucinous serous M-8245/3 Adenocarcinoid tumor M-8140/3 M-8140/6 M-8280/3 M-8550/3 M-8550/3 M-8370/3 M-8251/3 M-8215/3 M-8215/3 M-8244/3 M-8560/3 M-8560/3 M-8401/3 M-8147/3 M-8300/3 M-8160/3 M-8250/3 M-8250/3 M-8420/3 M-8270/3 M-8310/3 M-8310/3 M-8480/3 Adenocarcinoma (see also carcinoma) NOS NOS, metastatic acidophil (C75.1) acinar acinic cell adrenal cortical (C74.0) alveolar (C34._) anal ducts (C21.1) anal glands (C21.1) and carcinoid, combined and epidermoid carcinoma, mixed and squamous cell carcinoma, mixed apocrine basal cell (C07._, C08._) basophil (C75.1) bile duct (C22.1, C24.0) bronchiolar (C34.1) bronchiolo-alveolar, NOS (C34._) ceruminous (C44.2) chromophobe (C75.1) clear cell, NOS clear cell, mesonephroid colloid M-8255/3 Combined carcinoid and adenocarcinoma (C34._) small cell-adenocarcinoma (C34._) with other types of carcinoma M-8200/3 M-8145/3 M-8408/3 M-8500/3 M-8500/3 M-8413/3 M-8408/3 M-9070/3 M-8384/3 cylindroid diffuse type (C16._) digital papillary (C44._) duct, NOS (C50._) duct, infiltrating (C50._) eccrine, NOS (C44._) eccrine papillary (C44._) embryonal endocervical type M-8380/3 M-8383/3 M-8382/3 Endometrioid NOS ciliated cell variant secretory variant M-8244/3 M-8045/3 M-8280/3 M-8154/3 M-8333/3 Adenocarcinoma, continued eosinophil (C75.1) exocrine and islet cell, mixed (C25._) fetal (C73.9) M-8330/3 M-8340/3 M-8332/3 M-8332/3 M-8331/3 Follicular NOS (C73.9) and papillary (C73.9) moderately differentiated (C73.9) trabecular (C73.9) well differentiated (C73.9) M-8480/3 M-8320/3 M-8576/3 M-8290/3 M-8210/3 M-8210/3 M-8220/3 M-8221/3 M-8210/3 gelatinous [obs] granular cell hepatoid Hurthle cell (C73.9) in a polyp, NOS in adenomatous polyp in adenomatous polyposis coli (C18._) in multiple adenomatous polyps in polypoid adenoma M-8140/2 M-8210/2 M-8210/2 M-8210/2 M-8210/2 M-8263/2 M-8261/2 In situ NOS in a polyp, NOS in adenomatous polyp in polypoid adenoma in tubular adenoma in tubulovillous adenoma in villous adenoma M-8210/3 M-8263/3 M-8261/3 M-8503/3 M-8500/3 M-8530/3 M-8144/3 M-8504/3 in tubular adenoma in tubulovillous adenoma in villous adenoma infiltrating and papillary infiltrating duct (C50._) inflammatory (C50._) intestinal type (C16._) intracystic papillary M-8500/2 M-8503/2 M-8503/2 M-8503/3 Intraductal noninfiltrating, NOS noninfiltrating, papillary (C50._) papillary, NOS (C50._) papillary, with invasion (C50._) M-8150/3 M-8154/3 M-8520/3 M-8525/3 M-8510/3 M-9110/3 M-8310/3 islet cell (C25._) islet cell and exocrine, mixed (C25._) lobular (C50._) low grade, polymorphous medullary mesonephric mesonephroid, clear cell M-8560/3 M-8560/3 M-8244/3 M-8323/3 M-8154/3 135 Mixed adenocarcinoma and epidermoid carcinoma adenocarcinoma and squamous cell carcinoma carcinoid-adenocarcinoma cell islet cell and exocrine (C25._) Alphabetic Index M-8200/3 Adenocystic carcinoma Adenocarcinoma, continued mucinous, NOS mucinous, endocervical type mucin-producing mucin-secreting mucoid mucoid cell (C75.1) mucous nonencapsulated sclerosing (C73.9) noninfiltrating, intraductal, NOS noninfiltrating, intraductal, papillary (C50._) M-8290/3 oncocytic M-8290/3 oxyphilic M-8480/3 M-8482/3 M-8481/3 M-8481/3 M-8480/3 M-8300/3 M-8480/3 M-8350/3 M-8500/2 M-8503/2 M-8260/3 M-8340/3 M-8503/3 M-8408/3 M-8408/3 M-8340/3 M-8503/3 M-8504/3 M-8503/2 M-8503/2 M-8503/3 M-8460/3 M-8450/3 M-8263/3 M-8214/3 M-8525/3 M-8470/3 M-8312/3 M-8141/3 M-8350/3 M-8410/3 M-8441/3 M-8460/3 M-8490/3 M-8230/3 M-8143/3 M-8400/3 M-8525/3 M-8190/3 M-8211/3 M-8263/3 M-8262/3 M-8322/3 M-8573/3 M-8571/3 M-8571/3 M-8255/3 M-8574/3 M-8571/3 M-8255/3 M-8572/3 M-8570/3 M-9013/0 M-8313/0 M-8313/1 Papillary NOS and follicular (C73.9) and infiltrating (C50._) digital (C44._) eccrine (C44._) follicular variant (C73.9) infiltrating (C50._) intracystic intraductal, NOS (C50._) intraductal, noninfiltrating (C50._) intraductal, with invasion (C50._) serous (C56.9) papillocystic papillotubular parietal cell (C16._) polymorphous low grade pseudomucinous (C56.9) renal cell (C64.9) scirrhous sclerosing, nonencapsulated (C73.9) sebaceous (C44._) serous, NOS serous, papillary (C56.9) signet ring cell solid, with mucin formation superficial spreading sweat gland (C44._) terminal duct trabecular tubular tubulopapillary villous water-clear cell (C75.0) with apocrine metaplasia with cartilaginous and osseous metaplasia with cartilaginous metaplasia with mixed subtypes with neuroendocrine differentiation with osseous metaplasia with other types of carcinoma, combined with spindle cell metaplasia with squamous metaplasia Adenofibroma NOS clear cell (C56.9) clear cell, of borderline malignancy (C56.9) M-8381/0 M-8381/1 M-8381/3 Endometrioid NOS borderline malignancy malignant M-9015/0 M-9015/1 M-8965/0 M-9013/0 mucinous mucinous, of borderline malignancy nephrogenic (C64.9) papillary M-9014/0 M-9014/1 M-9014/3 Serous NOS borderline malignancy malignant M--------- Adenofibrosis (see SNOMED) C11.1 Adenoid M-8098/3 M-8200/3 M-8075/3 Adenoid basal carcinoma (C53._) cystic carcinoma squamous cell carcinoma M-8100/0 Adenoides cysticum, epithelioma (C44._) M-8324/0 Adenolipoma M-8561/0 Adenolymphoma (C07._, C08._) 136 M-8140/0 M-8280/0 M-8281/0 M-8550/0 M-8550/0 M-8550/0 M-8210/3 Adenoma NOS acidophil (C75.1) acidophil-basophil, mixed (C75.1) acinar acinar cell acinic cell adenocarcinoma in polypoid M-8370/0 M-8373/0 M-8371/0 M-8374/0 M-8375/0 M-8372/0 Adrenal cortical NOS (C74.0) clear cell (C74.0) compact cell (C74.0) glomerulosa cell (C74.0) mixed cell (C74.0) pigmented (C74.0) M-8408/1 M-8251/0 M-8401/0 M-8140/1 M-8147/0 M-8300/0 M-8281/0 M-8151/0 M-8160/0 M-8372/0 aggressive digital papillary (C44._) alveolar (C34._) apocrine atypical basal cell (C07._, C08._) basophil (C75.1) basophil-acidophil, mixed (C75.1) beta cell (C25._) bile duct (C22.1, C24.0) black (C74.0) Alphabetic Index Adenoma, continued Bronchial M-8140/1 NOS (C34._) M-8240/3 carcinoid (C34._) M-8200/3 cylindroid (C34._) M-8149/0 M-8420/0 M-8321/0 M-8270/0 M-8310/0 M-8334/0 M-8408/1 M-8503/0 M-8408/0 M-8191/0 M-8380/0 M-8380/1 M-8280/0 M-8333/0 M-8212/0 canalicular ceruminous (C44.2) chief cell (C75.0) chromophobe (C75.1) clear cell colloid (C73.9) digital papillary, aggressive (C44._) duct, NOS eccrine papillary (C44._) embryonal endometrioid, NOS endometrioid, borderline malignancy eosinophil (C75.1) fetal (C73.9) flat M-8330/0 M-8330/1 M-8290/0 Follicular NOS (C73.9) atypical (C73.9) oxyphilic cell (C73.9) M-8300/0 M-8982/0 M-8506/0 M-8290/0 M-8290/0 M-8290/0 hepatocellular (C22.0) Hurthle cell (C73.9) intracystic, papillary intraductal papillary-mucinous (C25._) islet cell (C25._) lactating (C50._) liver cell (C22.0) macrofollicular (C73.9) mesonephric metanephric (C64.9) microcystic, NOS (C25._) microcystic, serous microfollicular (C73.9) mixed acidophil-basophil (C75.1) mixed cell monomorphic mucinous mucinous-papillary, intraductal (C25._) mucoid cell (C75.1) myoepithelial nipple (C50.0) oncocytic oxyphilic oxyphilic cell follicular (C73.9) M-8260/0 M-8408/1 M-8408/0 M-8504/0 Papillary NOS aggressive digital (C44._) eccrine (C44._) intracystic M-8170/0 M-8290/0 M-8504/0 M-8453/0 M-8150/0 M-8204/0 M-8170/0 M-8334/0 M-9110/0 M-8325/0 M-8202/0 M-8441/0 M-8333/0 M-8281/0 M-8323/0 M-8146/0 M-8480/0 M-8453/0 M-8453/0 M-8263/0 M-8640/1 M-8372/0 M-8272/0 M-8940/0 M-8941/3 Adenoma, continued Pick tubular pigmented (C74.0) pituitary, NOS (C75.1) pleomorphic pleomorphic, carcinoma in (C07._,C08._) M-8210/0 M-8210/3 M-8210/2 Polypoid NOS adenocarcinoma in adenocarcinoma in situ in M-8410/0 M--------M-8213/0 M-8441/0 M-8640/1 M-8390/0 M-8400/0 M-8640/1 M-8190/0 M-8336/0 sebaceous (C44._) sebaceum (see SNOMED) serrated (C18._) serous microcystic Sertoli cell skin appendage (C44._) sweat gland (C44._) testicular trabecular trabecular, hyalinizing (C73.9) M-8211/0 M-8210/3 M-8210/2 M-8640/1 Tubular NOS adenocarcinoma in adenocarcinoma in situ in Pick M-8263/0 M-8263/3 M-8263/2 Tubulovillous NOS adenocarcinoma in adenocarcinoma in situ in M-8263/0 villoglandular M-8261/0 M-8261/3 M-8261/2 Villous NOS adenocarcinoma in adenocarcinoma in situ in M-8322/0 M-9110/0 water-clear cell (C75.0) Wolffian duct M-8360/1 Adenomas, multiple, endocrine M-9054/0 Adenomatoid tumor, NOS M-9300/0 Adenomatoid tumor, odontogenic (C41._) papillary-mucinous, intraductal (C25._) papillotubular 137 M-8220/0 M-8360/1 M--------M-8150/0 M-8250/1 Adenomatosis NOS endocrine fibrosing (see SNOMED) islet cell (C25._) pulmonary (C34._) M-8213/0 M--------M--------- Adenomatous and hyperplastic polyp, mixed (C18._) goiter (see SNOMED) hyperplasia (see SNOMED) Alphabetic Index M-8210/0 M-8210/3 M-8210/2 M-8210/3 M-8210/2 M-8213/0 M-8220/0 M-8220/3 M-8221/0 M-8221/3 Adenomatous, continued Polyp NOS adenocarcinoma in adenocarcinoma in situ in carcinoma in carcinoma in situ in mixed, and hyperplastic (C18._) polyposis coli (C18._) polyposis coli, adenocarcinoma in (C18._) polyps, multiple polyps, multiple, adenocarcinoma in Adenomyoepithelioma (C50._) Adenomyoma Adenomyoma, atypical polypoid Adenomyomatous hyperplasia (see SNOMED) M--------- Adenomyosis, NOS (see SNOMED) M-8933/3 Adenosarcoma M-8983/0 M-8932/0 M-8932/0 M--------- M--------M--------M--------M--------- Adenosis NOS (see SNOMED) fibrosing (see SNOMED) florid (see SNOMED) sclerosing (see SNOMED) M-8560/3 Adenosquamous carcinoma C49.9 C49.4 C49.1 C49.1 C49.3 C49.6 C49.5 C49.2 C49.0 C49.0 C49.3 C49.0 C49.6 C49.2 C49.1 C49.5 C49.5 C49.1 C49.0 C49.2 C49.3 C49.5 C49.2 C49.2 C49.0 C49.2 C49.5 C49.0 C49.3 C49.1 C49.0 Adipose tissue NOS abdominal wall antecubital space arm axilla back buttock calf cervical region cheek chest wall face flank foot forearm gluteal region groin hand head hip infraclavicular region inguinal region knee leg neck popliteal space sacrococcygeal region scalp scapular region shoulder supraclavicular region C49.0 C49.2 C49.3 C49.6 Adipose tissue, continued temple thigh thoracic wall trunk, NOS C57.4 C57.4 Adnexa, NOS Adnexa, uterine M-8390/3 M-8407/3 M-8390/0 Adnexal carcinoma (C44._) microcystic, carcinoma (C44._) tumor, benign (C44._) M-8370/3 Adrenal cortical adenocarcinoma (C74.0) M-8370/0 M-8373/0 M-8371/0 M-8374/0 M-8375/0 M-8372/0 Adenoma NOS (C74.0) clear cell (C74.0) compact cell (C74.0) glomerulosa cell (C74.0) mixed cell (C74.0) pigmented (C74.0) M-8370/3 carcinoma (C74.0) M-8370/0 M-8370/0 M-8370/3 Tumor NOS (C74.0) benign (C74.0) malignant (C74.0) C74.9 C74.0 C74.1 Adrenal gland NOS cortex medulla M-8700/0 Adrenal medullary paraganglioma (C74.1) M-8700/3 Adrenal medullary paraganglioma, malignant (C74.1) M-8671/0 Adrenal rest tumor M-9080/0 M-8904/0 M-9080/0 M-9080/0 M-8620/1 M-8901/3 Adult cystic teratoma rhabdomyoma teratoma, NOS teratoma, cystic type, granulosa cell tumor (C56.9) type, pleomorphic rhabdomyosarcoma Adult T-cell leukemia (includes all variants) leukemia/lymphoma (HTLV-1 positive) (includes all variants) M-9827/3 lymphoma (includes all variants) M-9827/3 lymphoma/leukemia (includes all variants) M-9827/3 M-9827/3 138 Alphabetic Index M-8841/1 M-8408/1 M-8821/1 M-9948/3 M-9200/1 M-8408/1 Aggressive angiomyxoma digital papillary adenoma (C44._) fibromatosis NK-cell leukemia osteoblastoma (C40._, C41._) papillary adenoma, digital (C44._) C03.9 C03.1 C03.0 M-8745/3 Amelanotic desmoplastic melanoma (C44._) M-8730/3 Amelanotic melanoma (C44._) M-9961/3 Agnogenic myeloid metaplasia M-9767/1 AIL (Angioimmunoblastic lymphadenopathy) M-9705/3 AILD, peripheral T-cell lymphoma (Angioimmunoblastic Lymphadenopathy with Dysproteinemia) [obs] M-8077/2 AIN III (C21.1) C44.3 C26.9 M-9270/3 M-9271/0 M-9290/3 M-9330/0 M-9290/0 M-9290/3 M-9330/3 M-9290/3 M-9330/3 Ala nasi Alimentary tract, NOS M-9837/3 M-9837/3 M-9836/3 M-9836/3 M-9837/3 M-9836/3 M-9837/3 ALL B (see also M-9687/3) c (see also M-9728/3) common precursor B (see also M-9728/3) cortical T (see also M-9729/3) mature T (see also M-9729/3) Pre-B (see also M-9728/3) Pre-pre-B (see also M-9728/3) Pre-T (see also M-9729/3) Pro-B (see also M-9728/3) Pro-T (see also M-9729/3) C24.1 C20.9 M-8152/1 M-8152/3 M-9762/3 Alpha cell tumor, NOS (C25._) cell tumor, malignant (C25._) heavy chain disease C21.1 C21.1 M-9826/3 M-9836/3 M-9836/3 M-8251/3 M-8251/0 M-8902/3 M-8251/3 M-8250/3 M-8920/3 M-8902/3 M-9581/3 M-9133/3 Alveolar mucosa NOS lower upper C03.9 C03.1 C03.0 Alveolar ridge mucosa NOS lower upper C06.1 Alveolar sulcus Ameloblastic carcinoma (C41._) fibrodentinoma (C41._) fibrodentinosarcoma (C41._) fibroma (C41._) fibro-odontoma (C41._) fibro-odontosarcoma (C41._) fibrosarcoma (C41._) odontosarcoma (C41._) sarcoma (C41._) M-9310/0 Ameloblastoma, NOS (C41._) M-9310/3 Ameloblastoma, malignant (C41._) M--------- AML (see leukemia, AML) Ampulla of Vater Ampulla, rectal M--------- Amputation neuroma (see SNOMED) M-8345/3 Amyloid stroma, medullary carcinoma with (C73.9) M--------- Amyloid tumor (see SNOMED) M-9769/1 Amyloidosis, primary Anal canal Anal sphincter M-8215/3 Anal ducts adenocarcinoma (C21.1) M-8215/3 Anal glands adenocarcinoma (C21.1) M-8077/2 Anal intraepithelial neoplasia, grade III (C21.1) Alveolar adenocarcinoma (C34._) adenoma (C34._) and embryonal rhabdomyosarcoma, mixed carcinoma (C34._) cell carcinoma (C34._) rhabdomyosarcoma rhabdomyosarcoma and embryonal rhabdomyosarcoma, mixed soft part sarcoma tumor, intravascular bronchial (C34._) [obs] C03.9 C03.1 C03.0 Alveolus NOS lower upper M------/-4 Anaplastic (see grading code, page 34) M-9401/3 M-8021/3 M-9390/3 M-9392/3 M-9505/3 M-9082/3 M-9530/3 M-9382/3 M-9451/3 M-9062/3 M-9082/3 Anaplastic astrocytoma (C71._) carcinoma, NOS choroid plexus papilloma (C71.5) ependymoma (C71._) ganglioglioma malignant teratoma meningioma (C70._) oligoastrocytoma (C71._) oligodendroglioma (C71._) seminoma (C62._) teratoma, malignant M-9560/0 Ancient schwannoma M-8630/1 M-8630/0 M-8630/3 139 Androblastoma NOS benign malignant Alphabetic Index M-8640/1 M-8641/0 M-9980/3 M-9983/3 M-9984/3 M-9982/3 M-9982/3 M-9980/3 Androblastoma, continued tubular, NOS tubular, with lipid storage (C56.9) C76.5 C44.7 C49.2 C47.2 C40.3 C49.2 C49.2 C40.3 C47.2 C44.7 C49.2 C49.2 C49.2 C49.2 Anemia refractory, NOS (C42.1) refractory, with excess blasts (RAEB) (C42.1) refractory, with excess blasts in transformation (RAEB-T) (C42.1) [obs] refractory, with ringed sideroblasts (RARS) (C42.1) refractory, with sideroblasts (C42.1) refractory, without sideroblasts (C42.1) M--------M-9535/0 M-9161/1 M-9766/1 Aneurysmal bone cyst (see SNOMED) Angioblastic meningioma (C70._) [obs] Angioblastoma Angiocentric immunoproliferative lesion M-9130/1 M-9135/1 M-9130/1 Angioendothelioma NOS endovascular papillary spindle cell M-9363/0 Anlage tumor, retinal M-8623/1 Annular tubules, sex cord tumor with (C56.9) M-9680/3 Angioendotheliomatosis M-9160/0 M-9160/0 M-9160/0 M-9160/0 M--------M-9705/3 M-9767/1 M-9141/0 M-8894/0 M-8861/0 M-8856/0 M-9120/0 M--------M-8836/1 M--------M--------M-9534/0 M-8826/0 M-8860/0 M-8894/0 M-8894/3 M-8841/1 M-8841/1 M-9120/3 Ankle NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system bone connective tissue fibrous tissue joint peripheral nerve skin soft tissue subcutaneous tissue tendon tendon sheath Angiofibroma NOS cellular giant cell juvenile Angiofollicular hyperplasia, benign (see SNOMED) Angioimmunoblastic Lymphadenopathy with Dysproteinemia (AILD), peripheral T-cell lymphoma [obs] Angioimmunoblastic lymphadenopathy (AIL) Angiokeratoma Angioleiomyoma Angiolipoma, NOS Angiolipoma, infiltrating Angioma, NOS Angioma, spider (see SNOMED) Angiomatoid fibrous histiocytoma Angiomatosis, NOS (see SNOMED) Angiomatous lymphoid hamartoma (see SNOMED) Angiomatous meningioma (C70._) Angiomyofibroblastoma Angiomyolipoma Angiomyoma Angiomyosarcoma Angiomyxoma Angiomyxoma, aggressive Angiosarcoma C21.8 C21.8 Anorectal junction Anorectum C76.4 C44.6 C49.1 C49.1 C47.1 C49.1 C49.1 C49.1 C47.1 C44.6 C49.1 C49.1 Antecubital space NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue C71.9 C04.0 C38.1 C10.1 Anterior cranial fossa floor of mouth mediastinum surface of epiglottis C02.3 C02.0 C02.2 Anterior tongue NOS dorsal surface ventral surface C02.3 C02.0 C02.2 Anterior 2/3 of tongue NOS dorsal surface ventral surface C67.3 C11.3 C16.8 C31.0 C16.3 C30.1 140 Anterior wall bladder nasopharynx stomach, NOS (not classifiable to C16.0 to C16.4) Antrum NOS gastric mastoid Alphabetic Index C31.0 C16.3 C16.3 C21.0 C44.5 C49.3 C49.4 C75.5 Antrum, continued maxillary pyloric stomach Anus, NOS (excludes skin of anus and perianal skin C44.5) Anus, skin Aorta, NOS Aorta, abdominal Aortic body M-8691/1 Aortic body paraganglioma (C75.5) M-8691/1 Aortic body tumor (C75.5) C77.2 Aortic lymph node C49.1 C47.1 C40.0 C49.1 C49.1 C49.1 C77.3 C49.1 C47.1 C49.1 C44.6 C49.1 C49.1 C49.1 C49.1 Arm, continued adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue lymph node muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath M-8630/1 M-8630/0 M-8630/3 Arrhenoblastoma NOS benign malignant M-8691/1 Aorticopulmonary paraganglioma (C75.5) M-8401/3 M-8401/0 M-8401/0 M-8573/3 M-8573/3 Apocrine adenocarcinoma adenoma cystadenoma metaplasia, adenocarcinoma with metaplasia, carcinoma with M-9123/0 Arteriovenous hemangioma M-9044/3 Aponeuroses and tendons, clear cell sarcoma, (C49._) C49.9 C49.1 C49.2 M--------- Aponeurosis NOS palmar plantar Aponeurotic fibroma, juvenile (see SNOMED) ------------ Appendage (see skin appendage) C18.1 Appendix M-8248/1 Apudoma C70.9 C70.0 C70.1 Arachnoid NOS intracranial spinal Areola C41.9 C40.9 Articular cartilage, NOS Articular cartilage, limb, NOS C13.1 C32.1 Aryepiglottic fold NOS (excludes laryngeal aspect of aryepiglottic fold C32.1) hypopharyngeal aspect laryngeal aspect C32.3 C13.1 C18.2 Arytenoid cartilage Arytenoid fold Ascending colon M-9365/3 Askin tumor M-9430/3 Astroblastoma (C71._) M-9400/3 Astrocytic glioma (C71._) M-8240/1 Argentaffin carcinoid tumor, NOS M-8241/3 Argentaffin carcinoid tumor, malignant (except of appendix M-8240/1) M-8240/1 Argentaffinoma, NOS [obs] M-8241/3 Argentaffinoma, malignant [obs] C76.4 C44.6 C49.1 Artery NOS aorta, NOS aorta, abdominal axillary carotid celiac femoral iliac internal mammary mesenteric radial renal subclavian ulnar C13.1 M-9471/3 Arachnoidal cerebellar sarcoma, circumscribed (C71.6) [obs] C50.0 C49.9 C49.3 C49.4 C49.3 C49.0 C49.4 C49.2 C49.5 C49.3 C49.4 C49.1 C49.4 C49.3 C49.1 M-9400/3 M-9401/3 M-9400/3 M-9412/1 M-9400/3 Arm NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) 141 Astrocytoma NOS (C71._) anaplastic (C71._) cystic (C71._) [obs] desmoplastic infantile (C71._) diffuse (C71._) Alphabetic Index M-9400/3 M-9420/3 M-9420/3 M-9411/3 M-9421/1 M-9400/3 M-9400/3 M-9421/1 M-9421/1 M-9410/3 M-9383/1 M-9384/1 Astrocytoma, continued diffuse, low grade (C71._) fibrillary (C71._) fibrous (C71._) gemistocytic (C71._) juvenile (C71._). In North America, report as 9421/3 low grade (C71._) low grade diffuse (C71._) pilocytic (C71._) In North America, report as 9421/3 piloid (C71._) In North America, report as 9421/3 protoplasmic (C71._) subependymal, NOS (C71._) subependymal, giant cell (C71._) M-9400/3 Astroglioma (C71._) [obs] C41.2 C38.0 Atlas Atrium, cardiac M-8140/1 M-8249/3 M-9390/1 M-8830/1 M-8830/1 M-8330/1 M--------M-8893/0 M-8850/1 M-8513/3 M-9539/1 M-8932/0 M-8444/1 M-8442/1 Atypical adenoma carcinoid tumor choroid plexus papilloma (C71.5) fibrous histiocytoma fibroxanthoma follicular adenoma (C73.9) hyperplasia (see SNOMED) leiomyoma lipoma medullary carcinoma (C50._) meningioma (C70._) polypoid adenomyoma proliferating clear cell tumor (C56.9) proliferating serous tumor (C56.9) M-8380/1 M-8472/1 M-8462/1 Proliferative endometrioid tumor mucinous tumor (C56.9) papillary serous tumor (C56.9) M-9508/3 M-8585/1 M-8585/3 teratoid/rhabdoid tumor (C71._) thymoma, NOS (C37.9) thymoma, malignant (C37.9) C44.2 C44.2 C44.2 C30.1 Auditory canal, NOS canal, external meatus, external tube C44.2 C44.2 Auricle, NOS Auricle, skin C44.2 C44.2 C49.0 C77.0 Auricular canal, NOS canal, external cartilage lymph node C47.1 C47.2 C47.6 C47.4 C47.1 Autonomic nervous system NOS abdomen abdominal wall ankle antecubital space arm axilla back buttock calf cervical region cheek chest chest wall chin elbow face finger flank foot forearm forehead gluteal region groin hand head heel hip infraclavicular region inguinal region knee leg neck orbit pelvis perineum popliteal space pterygoid fossa sacrococcygeal region scalp scapular region shoulder supraclavicular region temple thigh thoracic wall thorax (excludes thymus, heart and mediastinum C37._, C38._) thumb toe trunk umbilicus wrist C76.1 C44.5 C49.3 C49.3 C47.3 C49.3 C49.3 Axilla NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue C47.9 C47.4 C47.4 C47.2 C47.1 C47.1 C47.3 C47.6 C47.5 C47.2 C47.0 C47.0 C47.3 C47.3 C47.0 C47.1 C47.0 C47.1 C47.6 C47.2 C47.1 C47.0 C47.5 C47.5 C47.1 C47.0 C47.2 C47.2 C47.3 C47.5 C47.2 C47.2 C47.0 C69.6 C47.5 C47.5 C47.2 C47.0 C47.5 C47.0 C47.3 C47.1 C47.0 C47.0 C47.2 C47.3 C47.3 M-8936/1 Autonomic nerve tumor, gastrointestinal 142 Alphabetic Index C49.3 C77.3 C47.3 C44.5 C49.3 C49.3 Axilla, continued fibrous tissue lymph node peripheral nerve skin soft tissue subcutaneous tissue C49.3 C77.3 C50.6 Axillary artery lymph node tail of breast C41.2 Axis M-8092/3 M-8092/3 M-8097/3 M-8092/3 M-8091/3 M-8091/3 M-8097/3 M-8090/3 M-8090/3 M--------M-8090/1 C71.0 B C76.7 C44.5 C49.6 C49.6 C47.6 C41.2 C49.6 C49.6 C49.6 C49.6 C49.6 C47.6 C49.6 C44.5 C49.6 C49.6 C49.6 C49.6 epithelioma (C44._) papilloma (see SNOMED) tumor (C44._) Basal ganglia M-8094/3 Basal-squamous cell carcinoma, mixed (C44._) M-8123/3 Basaloid carcinoma (C21.1) M-8083/3 Basaloid squamous cell carcinoma Back NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fascia fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath C01.9 C01.9 C71.7 Base of tongue, NOS Base of tongue, dorsal surface Basis pedunculi M-8281/0 M-8281/3 M-8300/3 M-8300/0 M-8300/3 Basophil acidophil adenoma, mixed (C75.1) acidophil carcinoma, mixed (C75.1) adenocarcinoma (C75.1) adenoma (C75.1) carcinoma (C75.1) M-8281/0 Basophil-acidophil adenoma, mixed (C75.1) M-8281/3 Basophil-acidophil carcinoma, mixed (C75.1) M-8094/3 Basosquamous carcinoma (C44._) M--------- Basosquamous papilloma (see SNOMED) M-8833/3 Bednar tumor (C44._) M-8319/3 Bellini duct carcinoma (C64.9) M-------/0 Benign (see behavior code, page 31) M-8151/0 Beta cell adenoma (C25._) M-8151/3 Beta cell tumor, malignant (C25._) M-9826/3 B-ALL (see also M-9687/3) M-9836/3 B-ALL, common precursor (see also M-9728/3) M-8722/3 Balloon cell melanoma (C44._) M-8722/0 Balloon cell nevus (C44._) M-9699/3 BALT lymphoma M--------- Barrett esophagus (see SNOMED) C51.0 Basal cell, continued Carcinoma, continued infiltrating, non-sclerosing (C44._) infiltrating, sclerosing (C44._) micronodular (C44._) morpheic (C44._) multicentric (C44._) multifocal superficial (C44._) nodular (C44._) pigmented (C44._) C49.1 C49.2 Biceps brachii muscle Biceps femoris muscle C24.0 C24.0 C24.0 C24.0 C24.0 C22.1 Bile duct NOS common cystic extrahepatic hepatic intrahepatic Bartholin gland M-8098/3 Basal carcinoma, adenoid (C53._) M-8147/3 M-8147/0 Basal cell adenocarcinoma (C07._, C08._) adenoma (C07._, C08._) M-8090/3 M-8092/3 M-8093/3 M-8093/3 M-8092/3 Carcinoma NOS (C44._) desmoplastic type (C44._) fibroepithelial (C44._) fibroepithelial, Pinkus type infiltrating, NOS (C44._) M-8160/3 M-8160/0 M-8160/3 M-8180/3 143 Bile duct adenocarcinoma (C22.1, C24.0) adenoma (C22.1, C24.0) carcinoma (C22.1, C24.0) carcinoma and hepatocellular carcinoma, mixed (C22.0) Alphabetic Index M-8161/3 M-8161/0 Bile duct, continued cystadenocarcinoma (C22.1, C24.0) cystadenoma (C22.1, C24.0) C22.1 C24.0 C24.9 Biliary canaliculus duct, NOS tract, NOS C41.9 C41.4 C40.3 C40.0 C41.2 C41.2 C41.2 C41.0 C40.1 C41.3 C41.4 C41.0 C41.0 C41.0 C41.0 C40.2 C40.2 C40.1 C40.3 C40.0 C41.0 C40.1 C40.3 C41.4 C40.0 C41.0 C41.4 C41.4 C41.4 C41.1 C41.1 C41.0 C40.2 C40.9 C40.2 C40.0 C41.1 C40.2 C40.3 C41.1 C42.1 C41.0 C40.1 C40.3 C41.0 C41.0 C41.0 C41.0 C40.3 C41.4 C40.3 C40.1 C41.4 C40.0 C41.3 C41.4 C40.0 C40.3 C40.1 C40.0 C40.0 C41.9 M-8264/0 Biliary papillomatosis (C22.1, C24.0) M-9053/3 M-9053/3 M-9043/3 Biphasic mesothelioma, NOS mesothelioma, malignant synovial sarcoma M--------M-8893/0 M-8372/0 M-8120/1 Birthmark (see SNOMED) Bizarre leiomyoma Black adenoma (C74.0) Bladder, papilloma of (C67._) C67.9 C67.3 C67.1 C67.5 C67.2 C67.5 C67.4 C67.0 C67.7 C67.6 C67.9 C67.9 C67.3 C67.2 C67.4 Bladder NOS anterior wall dome internal urethral orifice lateral wall neck posterior wall trigone urachus ureteric orifice urinary, NOS wall, NOS wall, anterior wall, lateral wall, posterior M-8000/3 M-8973/3 M-8972/3 Blastoma NOS pleuropulmonary pulmonary (C34._) C42.0 C49.9 Blood Blood vessel, NOS M-8780/0 M-8790/0 M-8780/0 M-8780/3 Blue nevus NOS (C44._) cellular (C44._) Jadassohn (C44._) malignant (C44._) C75.5 C75.4 C69.4 C75.5 C25.1 C75.5 C60.2 C16.2 C54.9 C57.7 Body aortic carotid ciliary coccygeal pancreas para-aortic penis stomach uterus Wolffian 144 Bone NOS acetabulum ankle arm atlas axis back calvarium carpal clavicle coccyx cranial ethmoid face (excludes mandible C41.1) facial femur fibula finger foot forearm frontal hand heel hip humerus hyoid ilium innominate ischium jaw, NOS jaw, lower jaw, upper leg limb, NOS long, lower limb long, upper limb lower jaw lower limb, long lower limb, short mandible marrow maxilla metacarpal metatarsal nasal occipital orbital parietal patella pelvic phalanx of foot phalanx of hand pubic radius rib sacrum scapula short, lower limb short, upper limb shoulder shoulder girdle skeletal Alphabetic Index C40.1 C41.0 Bone, continued skull sphenoid spinal column spine sternum tarsal temporal thumb tibia toe ulna upper jaw upper limb, long upper limb, short vertebra vertebral column (excludes sacrum and coccyx C41.4) wrist zygomatic C02.1 Border of tongue C41.0 C41.0 C41.2 C41.2 C41.3 C40.3 C41.0 C40.1 C40.2 C40.3 C40.0 C41.0 C40.0 C40.1 C41.2 C41.2 C71.0 C72.3 C71.5 C71.7 C71.5 C71.5 C71.8 C71.0 C71.0 C70.0 C71.9 C71.9 C71.9 C71.9 C70.0 C70.0 C70.9 C70.9 C70.0 C71.5 C70.0 C70.0 C70.0 C71.7 C71.7 C71.1 C71.1 C71.0 C71.0 C71.0 C71.2 C71.0 C71.7 C71.0 C71.0 C70.0 C70.0 C71.9 C71.0 C71.5 C71.5 C71.1 C71.4 C71.3 C71.2 C71.7 C70.9 C70.0 C70.0 C71.7 C71.4 C71.4 C71.7 C71.0 C72.3 C72.3 C71.0 C71.3 C71.7 C70.9 C70.0 C71.5 M-------/1 Borderline malignancy (see behavior code, page 31) M-8910/3 Botryoid sarcoma M-8910/3 Botryoides, sarcoma C26.0 C18.9 C17.9 Bowel NOS large, NOS small, NOS M-8081/2 Bowen disease (C44._) M-8081/2 Bowen type, intraepidermal squamous cell carcinoma (C44._) M-------/-6 B-precursor (see cell designation code, page 36) C77.3 C47.1 C47.1 Brachial lymph node nerve plexus C49.1 Brachialis muscle C71.9 C70.9 C70.0 C71.0 C71.7 C71.0 C71.0 C71.6 C71.6 C71.6 C71.0 C71.0 C70.0 C71.7 C71.5 C71.0 Brain NOS arachnoid, NOS arachnoid, intracranial basal ganglia basis pedunculi capsule, internal central white matter cerebellopontine angle cerebellum, NOS cerebellum, vermis cerebral cortex cerebral hemisphere cerebral meninges cerebral peduncle cerebral ventricle cerebral white matter 145 Brain, continued cerebrum chiasm, optic choroid plexus, NOS choroid plexus, fourth ventricle choroid plexus, lateral ventricle choroid plexus, third ventricle corpus callosum corpus striatum cortex, cerebral cranial dura mater cranial fossa, NOS cranial fossa, anterior cranial fossa, middle cranial fossa, posterior cranial meninges cranial pia mater dura, NOS dura mater, NOS dura mater, cranial ependyma falx, NOS falx cerebelli falx cerebri fourth ventricle, NOS fourth ventricle, choroid plexus frontal lobe frontal pole ganglia, basal globus pallidus hemisphere, cerebral hippocampus hypothalamus infratentorial, NOS insula internal capsule intracranial arachnoid intracranial meninges intracranial site island of Reil lateral ventricle, NOS lateral ventricle, choroid plexus lobe, frontal lobe, occipital lobe, parietal lobe, temporal medulla oblongata meninges, NOS meninges, cerebral meninges, cranial midbrain occipital lobe occipital pole olive operculum optic chiasm optic tract pallium parietal lobe peduncle, cerebral pia mater, NOS pia mater, cranial plexus, choroid Alphabetic Index C71.1 C71.4 C71.7 C71.0 C71.7 C71.0 C71.7 C71.9 C71.0 C71.8 C71.2 C70.0 C70.0 C71.0 C71.5 C71.5 C72.3 C71.2 C71.5 C71.5 C71.7 C71.7 C71.5 C71.5 C71.5 C71.5 C71.6 C71.0 C71.0 Brain, continued pole, frontal pole, occipital pons putamen pyramid rhinencephalon stem suprasellar supratentorial, NOS tapetum temporal lobe tentorium, NOS tentorium cerebelli thalamus third ventricle, NOS third ventricle, choroid plexus tract, optic uncus ventricle, NOS ventricle, cerebral ventricle, fourth, NOS ventricle, fourth, choroid plexus ventricle, lateral, NOS ventricle, lateral, choroid plexus ventricle, third, NOS ventricle, third, choroid plexus vermis, cerebellum white matter, central white matter, cerebral C10.4 Branchial cleft (site of neoplasm) C50.9 C50.0 C50.6 C50.1 C50.8 C50.8 C50.3 C50.5 C50.8 C50.0 C50.8 C50.3 C50.5 C50.2 C50.4 C44.5 C50.6 C50.8 C50.2 C50.4 Breast NOS (excludes skin of breast C44.5) areola axillary tail central portion inner lower lower-inner quadrant lower-outer quadrant midline nipple outer quadrant, lower-inner quadrant, lower-outer quadrant, upper-inner quadrant, upper-outer skin tail upper upper-inner quadrant upper-outer quadrant C34.9 C77.1 Bronchogenic Bronchopulmonary lymph node C34.9 C34.0 C34.3 C34.0 C34.2 C34.1 Bronchus NOS carina lower lobe main middle lobe upper lobe M-9000/0 M-9000/1 M-9000/3 M-9000/1 Brenner tumor NOS (C56.9) borderline malignancy (C56.9) malignant (C56.9) proliferating (C56.9) C57.1 Broad ligament Burkitt cell leukemia (see also M-9687/3) lymphoma, NOS (includes all variants) (see also M-9826/3) M-9687/3 tumor [obs] (includes all variants) (see also M-9826/3) M-8140/1 M-8240/3 M-8200/3 Bronchial adenoma NOS (C34._) carcinoid (C34._) cylindroid (C34._) M-9133/3 Bronchial alveolar tumor, intravascular (C34._) [obs] C77.1 Bronchial lymph node M-8250/3 Bronchiolar adenocarcinoma (C34._) M-8250/3 Bronchiolar carcinoma (C34._) C34.9 Bronchiole M-8250/3 Bronchiolo-alveolar adenocarcinoma, NOS (C34._) M-8250/3 M-8252/3 M-8254/3 M-8253/3 M-8254/3 M-8254/3 M-8253/3 M-8252/3 M-8252/3 M-8254/3 Carcinoma NOS (C34._) Clara cell (C34._) Clara cell and goblet cell type (C34._) goblet cell type (C34._) indeterminate type (C34._) mixed mucinous and nonmucinous (C34._) mucinous (C34._) non-mucinous (C34._) type II pneumocyte (C34._) type II pneumocyte and goblet cell type (C34._) M-8100/0 Brooke tumor (C44._) C44.3 Brow M-8880/0 Brown fat tumor C06.9 C06.0 C06.1 M-9826/3 M-9687/3 146 Buccal cavity mucosa sulcus Alphabetic Index M-9836/3 C-ALL (see also M-9728/3) Burkitt, continued type, acute leukemia (see also M-9687/3) M-9687/3 type, malignant lymphoma, small noncleaved [obs] (includes all variants) (see also M-9826/3) M-9687/3 type, malignant lymphoma, undifferentiated [obs] (includes all variants) (see also M-9826/3) M-9826/3 M-9687/3 Burkitt-like lymphoma C49.9 Bursa, NOS C76.3 C44.5 C49.5 C49.5 C47.5 C49.5 C49.5 C49.5 C49.5 C47.5 C49.5 C44.5 C49.5 C49.5 Buttock NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C41.0 C65.9 C65.9 Calvarium Calyces, renal Calyx, renal C21.1 C44.2 C44.2 C44.2 C44.2 C53.0 C44.2 C53.0 C16.4 Canal anal auditory, NOS auditory, external auricular, NOS auricular, external cervical ear endocervical pyloric M-8149/0 Canalicular adenoma C22.1 M-8000/3 Cancer (see coding guidelines, page 31) C44.1 C44.1 C44.1 M-8345/3 C cell carcinoma (C73.9) M-9340/0 M-8110/0 M-9301/0 M-8642/1 Calcifying epithelial odontogenic tumor (C41._) epithelioma of Malherbe (C44._) odontogenic cyst (C41._) Sertoli cell tumor, large cell M--------- Calcinosis, tumoral (see SNOMED) C76.5 C44.7 C49.2 C49.2 C49.2 C49.2 C49.2 C49.2 C49.2 C44.7 C49.2 C49.2 C49.2 C49.2 Calf NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue connective tissue fatty tissue fibrous tissue muscle skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath Capsule, internal M-8934/3 Carcinofibroma C Caecum Canthus NOS inner outer M-9131/0 Capillary hemangioma M-9171/0 Capillary lymphangioma C71.0 C18.0 Canaliculus, biliary M-8240/3 M-8240/1 M-8244/3 M-8244/3 M-8240/3 M-8244/3 M-8244/3 M-8241/3 M-8242/1 M-8242/3 M-8241/3 M-8242/1 M-8243/3 M-8244/3 M-8243/3 M-8241/3 M-9091/1 M-9091/1 M-8245/1 M-8240/3 M-8240/1 M-8240/1 147 Carcinoid NOS (except of appendix M-8240/1) NOS, of appendix (C18.1) adenocarcinoma and, combined adenocarcinoma and, mixed bronchial adenoma (C34._) combined carcinoid and adenocarcinoma composite EC cell ECL cell, NOS ECL cell, malignant enterochromaffin cell enterochromaffin-like cell, NOS goblet cell mixed carcinoid-adenocarcinoma mucinous serotonin producing struma ovarii and (C56.9) strumal (C56.9) tubular Tumor NOS (except of appendix M-8240/1) NOS, of appendix (C18.1) argentaffin, NOS Alphabetic Index Carcinoid, continued Tumor, continued M-8241/3 argentaffin, malignant (except of appendix M-8240/1) M-8249/3 atypical M-8240/1 uncertain malignant potential M-8240/3 M-8010/3 M-8010/6 M-8075/3 M-8280/3 M-8281/3 M-8550/3 M-8550/3 M-8200/3 M-8560/3 M-8390/3 M-8407/3 M-8370/3 M-8251/3 M-8250/3 M-9270/3 M-8021/3 M-8098/3 adenosquamous adnexal (C44._) adnexal, microcystic (C44._) adrenal cortical (C74.0) alveolar (C34._) alveolar cell (C34._) ameloblastic (C41._) anaplastic, NOS basal, adenoid (C53._) M-8094/3 M-8123/3 M-8083/3 M-8300/3 M-8281/3 M-8094/3 M-8319/3 M-8160/3 M-8180/3 M-8081/2 M-8253/3 M-8254/3 M-8254/3 Carcinoma (see also adenocarcinoma) NOS NOS, metastatic acantholytic squamous cell acidophil (C75.1) acidophil-basophil, mixed (C75.1) acinar acinar cell adenocystic M-8098/3 M-8200/3 M-8075/3 M-8090/3 M-8092/3 M-8091/3 M-8250/3 M-8252/3 M-8254/3 typical Adenoid basal (C53._) cystic squamous cell M-8090/3 M-8092/3 M-8093/3 M-8093/3 M-8097/3 M-8092/3 M-8091/3 M-8091/3 M-8097/3 M-8092/3 M-8250/3 M-8253/3 M-8252/3 M-8252/3 M-8254/3 M-8345/3 M-8420/3 M-9390/3 M-8270/3 M-8317/3 M-8310/3 M-8507/2 M-8124/3 M-8319/3 M-8480/3 M-8523/3 148 C cell (C73.9) ceruminous (C44.2) choroid plexus (C71.5) chromophobe (C75.1) chromophobe cell renal (C64.9) clear cell clinging, intraductal (C50._) cloacogenic (C21.2) collecting duct (C64.9) colloid colloid and infiltrating duct (C50._) M-8045/3 M-8045/3 M-8045/3 M-8051/3 condylomatous M-8201/3 M-8523/3 M-8201/2 Cribriform NOS and infiltrating duct (C50._) in situ (C50._) M-8121/3 M-8508/3 M-8145/3 cylindrical cell (C30.0, C31._) cystic hypersecretory (C50._) diffuse type (C16._) M-8500/3 M-8500/3 M-8319/3 M-8514/3 M-8500/3 M-8523/3 M-8523/3 M-8522/3 Duct NOS cell collecting (C64.9) desmoplastic type infiltrating (C50._) infiltrating and colloid (C50._) infiltrating and cribriform (C50._) infiltrating and lobular carcinoma (C50._) M-8180/3 basal-squamous cell, mixed (C44._) basaloid (C21.1) basaloid squamous cell basophil (C75.1) basophil-acidophil, mixed (C75.1) basosquamous (C44._) Bellini duct (C64.9) bile duct (C22.1, C24.0) bile duct and hepatocellular, mixed (C22.0) Bowen type, intraepidermal squamous cell (C44._) Bronchiolo-alveolar NOS (C34._) Clara cell (C34._) Clara cell and goblet cell type (C34._) goblet cell type (C34._) indeterminate type (C34._) mixed mucinous and nonmucinous (C34._) mucinous (C34._) non-mucinous (C34._) type II pneumocyte (C34._) type II pneumocyte and goblet cell type (C34._) Combined adenocarcinoma with other types of carcinoma hepatocellular and cholangiocarcinoma (C22.0) small cell small cell-large cell (C34._) small cell-squamous cell (C34._) M-8255/3 Basal cell NOS (C44._) desmoplastic type (C44._) fibroepithelial (C44._) fibroepithelial, Pinkus type micronodular (C44._) morpheic (C44._) multicentric (C44._) multifocal superficial (C44._) nodular (C44._) non-sclerosing, infiltrating (C44._) pigmented (C44._) sclerosing, infiltrating (C44._) superficial, multifocal (C44._) Carcinoma, continued bronchiolar (C34._) Alphabetic Index M-8522/3 M-8523/3 M-8541/3 M-8523/3 Carcinoma, continued Duct, continued infiltrating and lobular carcinoma in situ (C50._) infiltrating and mucinous (C50._) infiltrating and Paget disease, breast (C50._) infiltrating and tubular (C50._) M-8346/3 M-8480/3 M-8031/3 M-8030/3 M-8015/3 M-8315/3 M-8320/3 M-8620/3 M-8172/3 M-8501/2 M-8201/2 M-8507/2 M-8503/2 M-8230/2 Ductal NOS and lobular (C50._) cribriform type (C50._) in situ, NOS (C50._) in situ and infiltrating lobular (C50._) in situ, comedo type (C50._) in situ, cribriform type (C50._) in situ, micropapillary (C50._) in situ, papillary (C50._) in situ, solid type (C50._) M-8521/3 ductular, infiltrating (C50._) M-9070/3 M-9081/3 M-9101/3 M-9071/3 M-9072/3 Embryonal NOS and teratoma, mixed combined with choriocarcinoma infantile polyembryonal type M-8380/3 M-8280/3 endometrioid, NOS eosinophil (C75.1) M-8010/2 M-8522/3 M-8070/2 M-8076/2 M-8071/3 M-8072/3 M-8052/3 M-8073/3 M-8074/3 M-8051/3 Epidermoid NOS and adenocarcinoma, mixed in situ, NOS in situ with questionable stromal invasion keratinizing large cell, nonkeratinizing papillary small cell, nonkeratinizing spindle cell verrucous M-8562/3 M-8171/3 epithelial-myoepithelial fibrolamellar hepatocellular (C22.0) M-8500/3 M-8522/3 M-8201/3 M-8500/2 M-8522/3 M-8070/3 M-8560/3 M-8070/2 M-8076/2 M-8330/3 M-8340/3 M-8335/3 M-8335/3 M-8332/3 M-8290/3 M-8332/3 M-8331/3 M-8170/3 M-8180/3 M-8180/3 M-8174/3 M-8171/3 M-8175/3 M-8173/3 M-8172/3 M-8173/3 M-8575/3 M-8290/3 M-8210/3 M-8210/3 M-8941/3 149 Hepatocellular NOS (C22.0) and bile duct, mixed (C22.0) and cholangiocarcinoma, combined (C22.0) clear cell type (C22.0) fibrolamellar (C22.0) pleomorphic type (C22.0) sarcomatoid (C22.0) scirrhous (C22.0) spindle cell variant (C22.0) hepatoid Hurthle cell (C73.9) in a polyp, NOS in adenomatous polyp in pleomorphic adenoma (C07._, C08._) M-8522/2 M-8050/2 M-8120/2 In situ NOS ductal and infiltrating lobular (C50._) epidermoid, NOS epidermoid, with questionable stromal invasion (C53._) in a polyp, NOS in adenomatous polyp lobular, NOS (C50._) lobular carcinoma and infiltrating duct (C50._) lobular and intraductal (C50._) papillary urothelial (C67._) M-9071/3 infantile, embryonal M-8500/3 M-8523/3 M-8523/3 M-8522/3 M-8522/3 M-8523/3 M-8541/3 M-8523/3 M-8523/3 Infiltrating duct NOS (C50._) and colloid (C50._) and cribriform (C50._) and lobular (C50._) and lobular in situ (C50._) and mucinous (C50._) and Paget disease, breast (C50._) and tubular (C50._) mixed with other types (C50._) M-8521/3 infiltrating ductular (C50._) M-8210/2 M-8210/2 M-8520/2 M-8522/3 Follicular NOS (C73.9) and papillary (C73.9) encapsulated (C73.9) minimally invasive (C73.9) moderately differentiated (C73.9) oxyphilic cell (C73.9) trabecular (C73.9) well differentiated (C73.9) Carcinoma, continued follicular-medullary, mixed (C73.9) gelatinous [obs] giant cell giant cell and spindle cell glassy cell glycogen-rich (C50._) granular cell granulosa cell (C56.9) hepatic, sclerosing (C22.0) Alphabetic Index Carcinoma, continued Infiltrating lobular M-8520/3 NOS (C50._) M-8522/3 and ductal carcinoma in situ (C50._) M-8524/3 mixed with other types (C50._) M-8530/3 M-8337/3 M-8144/3 M-8504/3 M-8504/2 M-8504/3 inflammatory (C50._) insular (C73.9) intestinal type (C16._) intracystic, NOS intracystic, noninfiltrating intracystic, papillary M-8500/2 M-8522/3 M-8522/2 M-8543/3 M-8507/2 M-8507/2 M-8500/2 M-8503/2 M-8503/2 M-8503/2 M-8230/2 Intraductal NOS and lobular (C50._) and lobular in situ (C50._) and Paget disease, breast (C50._) clinging (C50._) micropapillary (C50._) noninfiltrating, NOS noninfiltrating, papillary (C50._) papillary, NOS (C50._) papillary, noninfiltrating (C50._) solid type M-8070/2 M-8081/2 M-8010/2 M-8070/2 M-9270/3 M-8150/3 M-8502/3 M-8012/3 M-8072/3 M-8013/3 M-8071/3 M-8072/3 M-8014/3 M-8045/3 M-8314/3 M-8170/3 M-8520/3 M-8522/3 M-8522/3 M-8522/3 M-8520/3 M-8522/3 M-8520/2 M-8522/3 M-8522/2 M-8520/2 M-8082/3 M-8082/3 M-8110/3 M-8510/3 M-8513/3 M-8345/3 M-8512/3 Medullary NOS atypical (C50._) with amyloid stroma (C73.9) with lymphoid stroma M-8346/3 M-8347/3 M-8247/3 M-8575/3 M-8010/6 M-8490/6 M-8095/3 M-8407/3 M-8076/3 medullary-follicular mixed (C73.9) medullary-papillary, mixed (C73.9) Merkel cell (C44._) metaplastic, NOS metastatic, NOS metastatic signet ring cell metatypical (C44._) microcystic adnexal (C44._) microinvasive squamous cell (C53._) M-8507/2 M-8460/3 M-8131/3 Micropapillary intraductal (C50._) serous (C56.9) transitional cell (C67._) intraepidermal, NOS intraepidermal squamous cell, Bowen type (C44._) intraepithelial, NOS intraepithelial squamous cell intraosseous, primary (C41.1) islet cell (C25._) juvenile, breast (C50._) M-8154/3 M-8560/3 M-8560/3 Large cell NOS epidermoid, nonkeratinizing neuroendocrine squamous cell, keratinizing squamous cell, nonkeratinizing, NOS with rhabdoid phenotype M-8346/3 M-8347/3 M-8347/3 M-8045/3 M-8560/3 M-8094/3 M-8154/3 M-8346/3 M-8180/3 M-8523/3 M-8524/3 large cell-small cell, combined (C34._) lipid-rich (C50._) liver cell (C22.0) M-8481/3 M-8481/3 M-8480/3 M-8523/3 M-8430/3 M-8480/3 M-8480/3 M-8091/3 M-8091/3 Lobular NOS (C50._) and ductal (C50._) and infiltrating duct (C50._) and intraductal (C50._) infiltrating (C50._) infiltrating and ductal in situ (C50._) in situ (C50._) in situ and infiltrating duct (C50._) in situ and intraductal (C50._) noninfiltrating (C50._) M-8982/3 M-8562/3 150 Carcinoma, continued lymphoepithelial lymphoepithelioma-like matrical (C44._) Mixed acinar-endocrine (C25._) adenocarcinoma and epidermoid adenocarcinoma and squamous cell basal-squamous cell (C44._) ductal-endocrine (C25._) follicular-medullary (C73.9) hepatocellular and bile duct (22.0) medullary-follicular (C73.9) medullary-papillary (C73.9) papillary-medullary (C73.9) small cell squamous cell and adenocarcinoma with other types, infiltrating duct (C50._) with other types, infiltrating lobular (C50._) mucin-producing mucin-secreting mucinous mucinous and infiltrating duct (C50._) mucoepidermoid mucoid mucous multicentric basal cell (C44._) multifocal superficial basal cell (C44._) myoepithelial myoepithelial-epithelial Alphabetic Index Carcinoma, continued Neuroendocrine M-8246/3 NOS M-8013/3 large cell M-8247/3 primary cutaneous (C44._) M-8350/3 nonencapsulated sclerosing (C73.9) M-8504/2 M-8500/2 M-8503/2 M-8520/2 Noninfiltrating intracystic intraductal, NOS intraductal papillary (C50._) lobular (C.50_) M-8130/2 M-8130/2 M-8046/3 M-8042/3 M-9270/3 M-8290/3 M-8523/3 M-8524/3 M-8050/3 M-8340/3 M-8344/3 M-8350/3 M-8343/3 M-8052/3 M-8340/3 M-8050/2 M-8504/3 M-8503/2 M-8503/2 M-8342/3 M-8260/3 M-8461/3 M-8461/3 M-8052/3 M-8052/2 M-8052/2 M-8344/3 M-8260/3 M-8130/3 M-8130/2 M-8130/3 M-8130/2 M-8347/3 M-8453/2 M-8345/3 M-8214/3 M-8090/3 M-8110/3 Carcinoma, continued pituitary, NOS (C75.1) pleomorphic polygonal cell primary intraosseous carcinoma (C41.1) M-8461/3 primary serous papillary, peritoneum (C48.1) M-8075/3 pseudoglandular squamous cell M-8033/3 pseudosarcomatous M-8272/3 M-8022/3 M-8034/3 M-9270/3 non-invasive, papillary transitional cell (C67._) non-invasive, papillary urothelial (C67._) non-small cell (C34._) oat cell (C34._) odontogenic (C41._) oncocytic other types, infiltrating duct mixed with (C50._) other types, infiltrating lobular mixed with (C50._) Papillary NOS and follicular (C73.9) columnar cell (C73.9) diffuse sclerosing (C73.9) encapsulated (C73.9) epidermoid follicular variant (C73.9) in situ intracystic intraductal, NOS (C50._) intraductal, noninfiltrating (C50._) oxyphilic cell (C73.9) renal cell (C64.9) serous, primary, peritoneum (C48.1) serous surface (C56.9) squamous cell squamous cell in situ squamous cell, non-invasive tall cell (C73.9) thyroid (C73.9) transitional cell (C67._) transitional cell, non-invasive (C67._) urothelial (C67._) urothelial, non-invasive (C67._) M-8312/3 M-8317/3 M-8316/3 M-8260/3 M-8318/3 M-8318/3 Renal cell NOS (C64.9) chromophobe type (C64.9) cyst-associated (C64.9) papillary (C64.9) sarcomatoid (C64.9) spindle cell (C64.9) M-8317/3 M-8319/3 M-8041/3 M-8041/3 M-8033/3 M-8318/3 M-8121/3 M-8141/3 M-8350/3 M-8407/3 M-8410/3 M-8010/6 M-8502/3 renal, chromophobe cell (C64.9) renal, collecting duct type (C64.9) reserve cell round cell sarcomatoid sarcomatoid renal cell (C64.9) Schneiderian (C30.0, C31._) scirrhous sclerosing, nonencapsulated (C73.9) sclerosing sweat duct (C44._) sebaceous (C44._) secondary secretory, breast (C50._) M-8441/3 M-8461/3 M-8461/3 Serous NOS papillary, primary, peritoneum (C48.1) surface papillary (C56.9) M-8640/3 M-8589/3 M-8589/3 M-8490/3 M-8490/6 M-8231/3 M-8390/3 Sertoli cell (C62._) showing thymus-like differentiation showing thymus-like element signet ring cell signet ring cell, metastatic simplex skin appendage (C44._) M-8041/3 M-8043/3 M-8044/3 M-8041/3 M-8073/3 Small cell NOS fusiform cell intermediate cell neuroendocrine squamous cell, nonkeratinizing M-8045/3 papillary-medullary, mixed (C73.9) papillary-mucinous, intraductal, noninvasive (C25._) parafollicular cell (C73.9) parietal cell (C16._) pigmented basal cell (C44._) pilomatrix (C44._) M-8230/3 M-8452/3 M-8230/3 151 small cell-large cell, combined (C34._) Solid NOS pseudopapillary (C25._) with mucin formation Alphabetic Index Carcinoma, continued Spindle cell M-8032/3 NOS M-8030/3 and giant cell M-8318/3 renal cell (C64.9) M-8070/3 M-8120/3 M-8120/2 M-8130/2 M-8130/2 squamous Carcinoma, continued Urothelial NOS in situ non-invasive, papillary (C67._) papillary, non-invasive (C67._) M-8051/3 M-8051/3 M-8051/3 Verrucous NOS epidermoid squamous cell M-8051/3 M-8322/3 M-8573/3 M-8574/3 M-8035/3 M-8141/3 M-9110/3 warty water-clear cell (C75.0) with apocrine metaplasia with neuroendocrine differentiation with osteoclast-like giant cells with productive fibrosis Wolffian duct M-8070/2 M-8071/3 M-8071/3 M-8072/3 M-8070/6 M-8076/3 M-8072/3 M-8052/3 M-8052/2 M-8075/3 M-8074/3 M-8073/3 M-8074/3 M-8051/3 M-8078/3 Squamous cell NOS NOS, metastatic acantholytic adenoid basaloid clear cell type in situ, NOS in situ with questionable stromal invasion intraepidermal, Bowen type (C44._) intraepithelial keratinizing, NOS large cell, keratinizing large cell, nonkeratinizing, NOS metastatic, NOS microinvasive nonkeratinizing, NOS papillary papillary, non-invasive pseudoglandular sarcomatoid small cell, nonkeratinizing spindle cell verrucous with horn formation M-8407/3 M-8400/3 M-8407/3 M-8586/3 M-8585/3 M-8190/3 M-8120/3 sweat duct, sclerosing (C44._) sweat gland (C44._) syringomatous (C44._) thymic, NOS (C37.9) thymic, well differentiated (C37.9) trabecular transitional M-8692/1 Carotid body paraganglioma (C75.4) M-8692/1 Carotid body tumor (C75.4) M-8120/3 M-8120/2 M-8131/3 M-8130/3 M-8130/2 M-8122/3 M-8122/3 Transitional cell NOS in situ micropapillary (C67._) papillary (C67._) papillary, non-invasive (C67._) sarcomatoid spindle cell M-8102/3 M-8211/3 M-8523/3 M-8020/3 trichilemmal (C44._) tubular tubular and infiltrating duct (C50._) undifferentiated, NOS M-8070/3 M-8070/6 M-8075/3 M-8075/3 M-8083/3 M-8084/3 M-8070/2 M-8076/2 M-8081/2 M-8010/9 Carcinomatosis M-8980/3 M-8981/3 M-9342/3 Carcinosarcoma NOS embryonal odontogenic (C41._) C16.0 C16.0 C38.0 C38.0 C16.0 C34.0 C49.0 C75.4 Cardia, NOS Cardia, gastric Cardiac atrium Cardiac ventricle Cardioesophageal junction Carina Carotid artery Carotid body C40.1 Carpal bone C41.9 C41.9 C40.9 C32.3 C49.0 C41.3 C32.3 C32.3 C49.0 C32.3 C40.9 C30.0 C40.2 C32.3 Cartilage NOS articular, NOS articular of limb, NOS arytenoid auricular costal cricoid cuneiform ear laryngeal limb, NOS nasal semilunar thyroid Cartilaginous and osseous metaplasia, adenocarcinoma with M-9210/0 exostosis (C40._, C41._) M-8571/3 metaplasia, adenocarcinoma with M-8571/3 152 Alphabetic Index M-8589/3 CASTLE C72.1 Cauda equina M-9121/0 Cavernous hemangioma M-9172/0 Cavernous lymphangioma C06.9 C30.0 C06.9 C48.2 C30.1 Cavity buccal nasal (excludes nose, NOS C76.0) oral peritoneal tympanic M-9718/3 CD30+ T-cell lymphoma, primary cutaneous (C44._) M-9718/3 CD30+ T-cell lymphoproliferative disorder, primary cutaneous (C44._) C18.0 C49.4 C77.2 Cecum Celiac artery Celiac lymph node M-----/-9 Cell type not determined, not stated or not applicable (see cell designation code, page 36) M-9160/0 M-8790/0 M-9391/3 M-8810/1 M-8892/0 M-9560/0 Cerebellar liponeurocytoma sarcoma, NOS (C71.6) [obs] sarcoma, arachnoidal, circumscribed (C71.6) [obs] C71.6 C71.6 C71.6 Cerebellopontine angle Cerebellum, NOS Cerebellum, vermis C71.0 C71.0 C70.0 C71.7 C71.5 C71.0 Cerebral cortex hemisphere meninges peduncle ventricle white matter M-9381/3 Cerebri, gliomatosis (C71._) Cellular angiofibroma blue nevus (C44._) ependymoma (C71._) fibroma (C56.9) leiomyoma schwannoma Cemental dysplasia, periapical (C41._) Cementifying fibroma (C41._) Cementoblastoma, benign (C41._) Cementoma, NOS (C41._) Cementoma, gigantiform (C41._) Cemento-osseous dysplasia, periapical (C41._) M-9274/0 Cemento-ossifying fibroma (C41._) M-9272/0 M-9274/0 M-9273/0 M-9272/0 M-9275/0 M-9272/0 C72.9 C50.1 C71.0 M-9506/1 M-9480/3 M-9471/3 C71.0 C44.2 Cerebrum Ceruminal gland M-8420/3 M-8420/0 M-8420/3 Ceruminous adenocarcinoma (C44.2) adenoma (C44.2) carcinoma (C44.2) C53.0 C72.0 C15.0 C77.0 C47.0 C76.0 C53.8 Cervical canal cord esophagus lymph node plexus region, NOS stump M-8077/2 Cervical intraepithelial neoplasia, grade III (C53._) Central nervous system portion of breast white matter Central fibroma, odontogenic (C41._) giant cell granuloma (see SNOMED) neuroblastoma (C71._) neurocytoma odontogenic fibroma (C41._) osteosarcoma (C40._, C41._) osteosarcoma, conventional (C40._,C41._) M-9473/3 primitive neuroectodermal tumor, NOS (C71._) M-9321/0 M--------M-9500/3 M-9506/1 M-9321/0 M-9186/3 M-9186/3 153 C76.0 C44.4 C49.0 C49.0 C47.0 C49.0 C49.0 C49.0 C47.0 C44.4 C49.0 C49.0 Cervical region NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue C53.9 C53.8 C53.9 C53.9 Cervix NOS squamocolumnar junction uteri uterine Alphabetic Index M-9762/3 M-9762/3 M-9762/3 M-9762/3 Chain disease NOS, heavy alpha heavy gamma heavy mu heavy M--------- Chalazion (see SNOMED) C76.0 C44.3 C49.0 C49.0 C47.0 C49.0 C44.3 C49.0 C49.0 C06.0 C06.0 C47.0 C44.3 C49.0 C49.0 Cheek NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue external fatty tissue fibrous tissue internal mucosa peripheral nerve skin soft tissue subcutaneous tissue C47.0 C49.0 C49.0 C47.0 C44.3 C49.0 C49.0 M-9930/3 Chloroma C11.3 Chest NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system connective tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue C76.1 C44.5 C49.3 C49.3 C47.3 C49.3 C49.3 C49.3 C49.3 C47.3 C49.3 C44.5 C49.3 C49.3 Chest wall NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C72.3 Chiasm, optic C22.1 Cholangiole M-8160/0 Cholangioma (C22.1, C24.0) C24.0 Choledochal duct Cholesteatoma, NOS (see SNOMED) Cholesteatoma, epidermoid (see SNOMED) M-9181/3 Chondroblastic osteosarcoma (C40._, C41._) M-9230/0 Chondroblastoma, NOS (C40._, C41._) M-9230/3 Chondroblastoma, malignant (C40._, C41._) M--------M--------- M-9371/3 M-8862/0 M-8940/0 M-8940/3 Chondroid chordoma lipoma syringoma (C44._) syringoma, malignant (C44._) M-9220/0 M-9221/0 M-9221/0 Chondroma NOS (C40._, C41._) juxtacortical (C40._, C41._) periosteal (C40._, C41._) M-9220/1 Chondromatosis, NOS M--------- Chondromatosis, synovial (see SNOMED) M-9230/0 Chondromatous giant cell tumor (C40._, C41._) M-9241/0 Chondromyxoid fibroma (C40._, C41._) M-8321/0 Chief cell adenoma (C75.0) C44.3 C44.3 C49.0 Choana M-8160/3 Cholangiocarcinoma (C22.1, C24.0) M-8180/3 Cholangiocarcinoma and hepatocellular carcinoma, combined (C22.0) M-8693/1 Chemodectoma C76.1 C44.5 C49.3 C47.3 C49.3 C49.3 C47.3 C44.5 C49.3 C49.3 Chin, continued autonomic nervous system connective tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue Chin NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) 154 M-9220/3 M-9242/3 M-9243/3 M-9221/3 M-9240/3 M-9231/3 M-9221/3 Chondrosarcoma NOS (C40._, C41._) clear cell (C40._, C41._) dedifferentiated (C40._, C41._) juxtacortical (C40._, C41._) mesenchymal myxoid periosteal (C40._, C41._) M-9444/1 M-9444/1 M-9538/1 Chordoid glioma (C71._) glioma of third ventricle (C71.5) meningioma (C70._) Alphabetic Index M-9370/3 M-9371/3 M-9372/3 M-9471/3 Circumscribed arachnoidal cerebellar sarcoma [obs] (C71.6) M-8254/3 Clara cell and goblet cell type bronchioloalveolar carcinoma (C34._) M-8252/3 Clara cell bronchiolo-alveolar carcinoma (C34._) Chordoma NOS chondroid dedifferentiated M-9100/1 Chorioadenoma (C58.9) M-9100/1 Chorioadenoma destruens (C58.9) M-9120/0 Chorioangioma (C58.9) C41.3 Choriocarcinoma NOS combined with embryonal carcinoma combined with other germ cell elements M-9101/3 combined with teratoma M-9100/3 Chorioepithelioma M-9100/3 Chorionepithelioma M--------- Choristoma (see SNOMED) C69.3 Choroid C71.5 C71.7 C71.5 C71.5 Choroid plexus NOS fourth ventricle lateral ventricle third ventricle M-9950/3 M-9961/3 M-9960/3 M-9960/3 Chronic erythremia [obs] idiopathic myelofibrosis myeloproliferative disease myeloproliferative disorder M-8507/2 Clinging intraductal carcinoma (C50._) C51.2 Clitoris M-8124/3 Cloacogenic carcinoma (C21.2) C21.2 C77.4 C75.5 C75.5 C41.4 M--------- Cicatricial fibromatosis (see SNOMED) M-8383/3 Ciliated cell variant, endometrioid adenocarcinoma C69.4 Cleft, branchial (site of neoplasm) M-9391/3 M-8174/3 M-8402/0 M-8005/3 M-9538/1 M-9341/1 M-9044/3 M-8964/3 M-9044/3 M-8700/0 Chromaffin paraganglioma M-8700/0 Chromaffin tumor M-8700/0 Chromaffinoma Chromophobe adenocarcinoma (C75.1) adenoma (C75.1) carcinoma (C75.1) cell renal carcinoma (C64.9) C10.4 M-8443/0 M-8444/1 Choroid plexus papilloma NOS (C71.5) anaplastic (C71.5) atypical (C71.5) malignant (C71.5) M-8270/3 M-8270/0 M-8270/3 M-8317/3 M-8084/3 M-8005/0 M-8444/1 M-8310/0 M-8373/0 M-8310/3 M-9242/3 M-8313/3 M-8313/0 M-8313/1 M-9390/3 Choroid plexus carcinoma (C71.5) M-9390/0 M-9390/3 M-9390/1 M-9390/3 Clear cell (type) acanthoma (see SNOMED) adenocarcinofibroma (C56.9) adenocarcinoma, NOS adenocarcinoma, mesonephroid adenofibroma (C56.9) adenofibroma of borderline malignancy (C56.9) adenoma adrenal cortical adenoma (C74.0) carcinoma chondrosarcoma (C40._, C41._) cystadenocarcinofibroma (C56.9) cystadenofibroma (C56.9) cystadenofibroma of borderline malignancy (C56.9) cystadenoma (C56.9) cystic tumor of borderline malignancy (C56.9) ependymoma hepatocellular carcinoma, (C22.0) hidradenoma (C44._) malignant tumor meningioma (C70._) odontogenic tumor (C41._) sarcoma (except of kidney M-8964/3) sarcoma of kidney (C64.9) sarcoma of tendons and aponeuroses (C49._) squamous cell carcinoma tumor, NOS tumor, atypical proliferating (C56.9) M--------M-8313/3 M-8310/3 M-8310/3 M-8313/0 M-8313/1 M-9100/3 M-9101/3 M-9101/3 Clavicle Ciliary body Cloacogenic zone Cloquet lymph node Coccygeal body Coccygeal glomus Coccyx M-9230/0 Codman tumor (C40._, C41._) M-8077/2 CIN III, NOS (C53._) (see coding guidelines, page 31) M-8077/2 CIN III, with severe dysplasia (C53._) (see coding guidelines, page 31) C77.2 155 Colic lymph node Alphabetic Index M--------- Colitis cystica profunda (see SNOMED) M-8319/3 Collecting duct carcinoma (C64.9) M-8319/3 Collecting duct type renal carcinoma (C64.9) M--------- Colloid adenocarcinoma adenoma (C73.9) carcinoma carcinoma and infiltrating duct (C50._) goiter (see SNOMED) C18.9 C18.1 C18.2 C18.0 C18.6 C18.3 C18.6 C18.7 C19.9 C18.2 C18.7 C18.7 C18.5 C18.4 Colon NOS appendix ascending cecum descending hepatic flexure left pelvic rectosigmoid right sigmoid sigmoid flexure splenic flexure transverse M-8480/3 M-8334/0 M-8480/3 M-8523/3 C19.9 C41.2 C41.2 M-8244/3 M-9101/3 M-9101/3 M-9101/3 M-8180/3 M-8045/3 M-8045/3 M-8045/3 M-8045/3 Commissure labial laryngeal lip C24.0 C24.0 C77.2 Common bile duct duct duct lymph node M-8371/0 Compact cell adrenal cortical adenoma (C74.0) M-9100/0 Complete hydatidiform mole (C58.9) M-9282/0 Complex odontoma (C41._) M-9442/3 Component, glioblastoma with sarcomatous (C71._) M-8244/3 Composite carcinoid M-9596/3 Composite Hodgkin and non-Hodgkin lymphoma M-8760/0 Compound nevus (C44._) M-9281/0 Compound odontoma (C41._) Colon and rectum Column, spinal Column, vertebral (excludes sacrum and coccyx C41.4) C44.2 Concha M--------M--------M--------- Condyloma NOS (see SNOMED) acuminatum (see SNOMED) giant, acuminatum (see SNOMED) M-8051/3 Condylomatous carcinoma M-8761/0 Congenital cyst, NOS (see SNOMED) dysplasia, NOS (see SNOMED) fibromatosis, generalized fibrosarcoma melanocytic nevus, malignant melanoma in (C44._) melanosis (see SNOMED) myofibroblastic tumor, peribronchial (C34._) nevus, intermediate and giant (C44._) nevus, proliferative dermal lesion in (C44._) nevus, small (C44._) C69.0 Conjunctiva C49.9 C49.4 C49.4 C49.2 C49.1 C49.1 C49.3 C49.6 C49.5 C49.2 C49.0 C49.0 C49.3 Connective tissue NOS abdomen abdominal wall ankle antecubital space arm axilla back buttock calf cervical region cheek chest M--------M--------M-8824/1 M-8814/3 M-8761/3 M-8344/3 Columnar cell papillary carcinoma (C73.9) M-8121/1 Columnar cell papilloma C44.3 C00.6 C32.0 C00.6 Columnella M--------M-8827/1 Combined carcinoid and adenocarcinoma choriocarcinoma with embryonal carcinoma choriocarcinoma with other germ cell elements choriocarcinoma with teratoma hepatocellular carcinoma and cholangiocarcinoma (C22.0) small cell-adenocarcinoma (C34._) small cell carcinoma small cell-large cell carcinoma (C34._) small cell-squamous cell carcinoma (C34._) M-8761/1 M-8762/1 M-8501/2 Comedo type DCIS (C50._) M-8501/2 Comedo type ductal carcinoma in situ (C50._) M-8501/3 Comedocarcinoma, NOS (C50._) M-8501/2 Comedocarcinoma, noninfiltrating (C50._) 156 Alphabetic Index C49.1 C49.2 C49.6 C49.4 C49.1 Connective tissue, continued chest wall chin elbow face finger flank foot forearm forehead gluteal region groin hand head heel hip infraclavicular region inguinal region knee leg neck orbit pelvis perineum popliteal space pterygoid fossa sacrococcygeal region scalp scapular region shoulder supraclavicular region temple thigh thoracic wall thorax (excludes thymus, heart and mediastinum C37._, C38._) thumb toe trunk, NOS umbilicus wrist C72.0 Conus medullaris C49.3 C49.0 C49.1 C49.0 C49.1 C49.6 C49.2 C49.1 C49.0 C49.5 C49.5 C49.1 C49.0 C49.2 C49.2 C49.3 C49.5 C49.2 C49.2 C49.0 C69.6 C49.5 C49.5 C49.2 C49.0 C49.5 C49.0 C49.3 C49.1 C49.0 C49.0 C49.2 C49.3 C49.3 Coracobrachialis muscle C72.0 C32.1 C72.0 C72.0 C63.1 C72.0 C72.0 C32.0 Cord cervical false lumbar sacral spermatic spinal thoracic true C32.0 C32.1 C32.0 Cord, vocal NOS false true Cornea, NOS Cornea, limbus C71.8 C60.2 C16.2 C60.2 C16.2 C71.0 C54.9 Corpus callosum cavernosum gastric penis stomach striatum uteri C71.0 C74.0 Cortex, cerebral Cortex of adrenal gland M-9837/3 Cortical T ALL (see also M-9729/3) M-8584/1 M-8584/3 M-8583/1 M-8583/3 C41.3 C41.3 C68.0 Cortical thymoma (see also adrenal cortical) NOS (C37.9) malignant (C37.9) predominantly cortical, NOS (C37.9) predominantly cortical, malignant (C37.9) Costal cartilage Costovertebral joint Cowper gland M-9473/3 CPNET (C71._) M-9186/3 Conventional central osteosarcoma (C40._, C41._) C49.1 C69.1 C69.1 C41.0 C70.0 C70.0 C72.5 C70.0 Cranial bone dura mater meninges nerve, NOS pia mater C71.9 C71.9 C71.9 C71.9 Cranial fossa NOS anterior middle posterior C75.2 Craniopharyngeal duct M-9350/1 M-9351/1 M-9352/1 Craniopharyngioma NOS (C75.2) adamantinomatous (C75.2) papillary (C75.2) Cribriform (type) carcinoma carcinoma, infiltrating duct and (C50._) M-8201/2 carcinoma in situ (C50._) M-8201/3 ductal carcinoma (C50._) M-8201/2 ductal carcinoma in situ (C50._) M-8201/3 M-8523/3 C13.0 C32.3 C13.0 C69.4 157 Cricoid, NOS Cricoid cartilage Cricopharynx Crystalline lens Alphabetic Index C77.3 C48.1 C32.3 Cubital lymph node Cul de sac Cuneiform cartilage Cutaneous CD30+ T-cell lymphoproliferative disorder, primary (C44._) M-8832/0 histiocytoma, NOS (C44._) M--------horn (see SNOMED) M-9709/3 lymphoma, NOS (C44_) [obs] M-8247/3 neuroendocrine carcinoma, primary (C44._) M-8313/3 M-9015/3 M-9014/3 Cystadenocarcinofibroma clear cell (C56.9) mucinous serous M-8440/3 M-8551/3 M-8161/3 M-8380/3 M-8470/3 M-8470/2 Cystadenocarcinoma NOS acinar cell bile duct (C22.1, C24.0) endometrioid mucinous, NOS (C56.9) mucinous, non-invasive (C25._) M-9718/3 M-8121/3 M-8121/1 M-8200/3 M-8200/3 Cylindrical cell carcinoma (C30.0, C31._) Cylindrical cell papilloma (C30.0, C31._) Cylindroid adenocarcinoma Cylindroid bronchial adenoma (C34._) Cylindroma NOS (except cylindroma of skin M-8200/0) M-8200/0 eccrine dermal (C44._) M-8200/0 skin (C44._) M-8200/3 M--------M--------M-9301/0 M--------M--------- M-9084/3 M--------M--------M--------M--------M--------M--------M--------M--------- enterogenous (see SNOMED) epidermoid (see SNOMED) eruption (see SNOMED) follicular, jaw (see SNOMED) ganglion (see SNOMED) gingival, NOS (see SNOMED) gingival, odontogenic (see SNOMED) nasopalatine duct (see SNOMED) M--------M-9301/0 M--------M--------M--------M--------- Odontogenic NOS (see SNOMED) calcifying (C41._) dentigerous (see SNOMED) eruptive (see SNOMED) gingival (see SNOMED) primordial (see SNOMED) M--------M--------M-8103/0 M--------M--------M--------M--------M-8103/0 pilar (see SNOMED) primordial (see SNOMED) proliferating trichilemmal radicular (see SNOMED) sebaceous (see SNOMED) solitary (see SNOMED) thyroglossal duct (see SNOMED) trichilemmal, proliferating Papillary NOS (C56.9) mucinous (C56.9) pseudomucinous (C56.9) serous (C56.9) M-8470/3 M-8441/3 pseudomucinous, NOS (C56.9) serous, NOS (C56.9) M-9013/0 M-8313/0 M-8313/1 Cyst NOS (see SNOMED) aneurysmal bone (see SNOMED) calcifying odontogenic (C41._) congenital, NOS (see SNOMED) dentigerous (see SNOMED) Dermoid NOS with malignant transformation (C56.9) with secondary tumor M-9084/0 M-9084/3 M-8450/3 M-8471/3 M-8471/3 M-8460/3 Cystadenofibroma NOS clear cell (C56.9) clear cell, borderline malignancy (C56.9) M-8381/0 M-8381/1 M-8381/3 Endometrioid NOS borderline malignancy malignant M-9015/0 M-9015/1 M-9015/3 Mucinous NOS borderline malignancy malignant M-9014/0 M-9014/1 M-9014/3 Serous NOS borderline malignancy malignant Cystadenoma NOS apocrine bile duct (C22.1, C24.0) clear cell (C56.9) eccrine (C44._) endometrioid, NOS endometrioid, borderline malignancy lymphomatosum, papillary (C07._, C08._) M-8470/0 mucinous, NOS (C56.9) M-8472/1 mucinous, borderline malignancy (C56.9) M-8440/0 M-8401/0 M-8161/0 M-8443/0 M-8404/0 M-8380/0 M-8380/1 M-8561/0 M-8450/0 M-8451/1 M-8561/0 M-8471/0 158 Papillary NOS (C56.9) borderline malignancy (C56.9) lymphomatosum (C07._, C08._) mucinous, NOS (C56.9) Alphabetic Index M-8473/1 M-8471/0 M-8473/1 M-8460/0 M-8462/1 M-8470/0 M-8472/1 M-8441/0 M-8442/1 Cystadenoma, continued Papillary, continued mucinous, borderline malignancy (C56.9) pseudomucinous, NOS (C56.9) pseudomucinous, borderline malignancy (C56.9) serous, NOS (C56.9) serous, borderline malignancy (C56.9) C24.0 C24.0 M-8100/0 Cysticum, epithelioma adenoides (C44._) M--------- Cystitis cystica (see SNOMED) M--------- Cystitis, papillary (see SNOMED) pseudomucinous, NOS (C56.9) pseudomucinous, borderline malignancy (C56.9) serous, NOS (C56.9) serous, borderline malignancy (C56.9) M-8316/3 Cyst-associated renal cell carcinoma (C64.9) M-8452/1 M-9400/3 M-8200/3 M-8444/1 M---------M-9173/0 M-8508/3 M-9173/0 M-9055/1 M-9055/0 M-8472/1 M-8470/1 M-8959/1 M-8959/0 M-8959/3 M-8959/3 M-8452/1 M-8959/1 M-8462/1 M-9080/0 M-9080/0 M-8454/0 M-8444/1 M-8472/1 M-8470/1 M-8452/1 M-8462/1 Cystic bile duct Cystic duct M-8440/0 M-8470/0 M-8441/0 Cystoma NOS mucinous (C56.9) serous (C56.9) M-9020/1 M-9020/0 M-9020/3 Cystosarcoma phyllodes NOS (C50._) benign (C50._) [obs] malignant (C50._) M-9985/3 Cytopenia with multilineage dysplasia, refractory Cystic and solid tumor (C25._) astrocytoma (C71._) [obs] carcinoma, adenoid clear cell, tumor of borderline malignancy (C56.9) disease of the breast (see SNOMED) hygroma hypersecretory carcinoma (C50._) lymphangioma mesothelioma, NOS (C48._) mesothelioma, benign (C48._) [obs] mucinous, tumor of borderline malignancy (C56.9) mucinous, tumor with moderate dysplasia (C25._) nephroblastoma, partially differentiated (C64.9) M-9135/1 Dabska tumor D M-8500/2 M-8501/2 M-8503/2 DCIS NOS comedo type (C50._) papillary (C50._) M--------- Decidual change (see SNOMED) M-9243/3 M-9372/3 M-8858/3 Dedifferentiated chondrosarcoma (C40._, C41._) chordoma liposarcoma M-8831/0 Deep histiocytoma M-9560/0 Degenerated schwannoma Nephroma benign (C64.9) malignant (C64.9) multilocular, malignant (C64.9) papillary, tumor (C25._) partially differentiated, nephroblastoma (C64.9) serous papillary, tumor, borderline malignancy (C56.9) teratoma, NOS teratoma, adult C49.1 Deltoideus muscle M-9757/3 M-9758/3 M-9757/3 M-9758/3 Dendritic cell sarcoma, NOS sarcoma, follicular sarcoma, interdigitating tumor, follicular M--------- Dentigerous cyst (see SNOMED) M-9271/0 Dentinoma (C41._) M-9769/1 Deposition disease, immunoglobulin Tumor atrio-ventricular node (C38.0) clear cell, borderline malignancy (C56.9) mucinous, borderline malignancy (C56.9) mucinous, with moderate dysplasia (C25._) papillary (C25._) serous papillary, borderline malignancy (C56.9) Dermal and epidermal nevus (C44._) cylindroma, eccrine (C44._) eccrine, cylindroma (C44._) lesion, proliferative in congenital nevus (C44._) M-8750/0 nevus (C44._) M-8762/1 proliferative, lesion in congenital nevus (C44._) M-8760/0 M-8200/0 M-8200/0 M-8762/1 159 Alphabetic Index M-8832/0 Dermatofibroma, NOS (C44._) M-8832/0 Dermatofibroma lenticulare (C44._) M-8832/3 M-8832/3 M-8833/3 M-9362/3 Dermatofibrosarcoma NOS (C44._) protuberans, NOS (C44._) protuberans, pigmented (C44._) M-8921/3 M-8631/1 M-8634/1 Dermoid NOS cyst, NOS cyst with malignant transformation (C56.9) M-9084/3 cyst with secondary tumor M-9084/0 M-9084/0 M-9084/3 C62.1 C18.6 Descended testis Descending colon M-8821/1 M-8822/1 M-8821/1 Desmoid NOS abdominal extra-abdominal M-9412/1 M-8823/0 M-9412/1 M-9412/1 M-9412/1 M-9471/3 M-9471/3 M-8745/3 M-8745/3 M-9051/3 M-8806/3 M-8092/3 M-8514/3 Desmoplastic astrocytoma, infantile fibroma ganglioglioma, infantile infantile astrocytoma (C71._) infantile ganglioglioma medulloblastoma (C71.6) medulloblastoma, nodular (C71.6) melanoma, amelanotic (C44._) melanoma, malignant (C44._) mesothelioma small round cell tumor type, basal cell carcinoma (C44._) type, duct carcinoma M-8588/3 M-8574/3 M-8589/3 M-8574/3 M-9561/3 M-9561/3 M-9540/3 M-9540/3 M-9561/3 C26.9 Digestive organs, NOS M-8408/3 Digital papillary adenocarcinoma (C44._) M-8408/1 Digital papillary adenoma, aggressive (C44._) M-9501/0 Diktyoma, benign (C69._) M-9501/3 Diktyoma, malignant (C69._) M-8500/2 DIN 3 (C50._) Diaphragm Diaphragmatic lymph node M------/-1 Differentiated, NOS (see grading code, page 34) M-8851/3 M-9511/3 M-9080/0 M-8505/0 M-9513/3 M-8145/3 M-8145/3 Diffuse astrocytoma (C71._) astrocytoma, low grade (C71._) intraductal papillomatosis lipomatosis (see SNOMED) lymphosarcoma melanocytosis (C70.9) meningiomatosis (C70._) papillary carcinoma, sclerosing (C73.9) papillomatosis, intraductal retinoblastoma (C69.2) type, adenocarcinoma (C16._) type, carcinoma (C16._) M-9400/3 M-9400/3 M-8505/0 M--------M-9591/3 M-8728/0 M-9530/1 M-8350/3 M-9100/1 Destruens, chorioadenoma (C58.9) M-9840/3 Di Guglielmo disease (C42.1) [obs] C49.3 C77.1 Differentiation, continued pineal parenchymal tumor, intermediate (C75.3) rhabdomyosarcoma with ganglionic Sertoli-Leydig cell tumor, intermediate Sertoli-Leydig cell tumor, intermediate, with heterologous elements spindle epithelial tumor with thymus-like Differentiated liposarcoma retinoblastoma (C69.2) teratoma C41.2 Disc, intervertebral M-9762/3 M-8081/2 M-9960/3 M-9769/1 M-9840/3 M-9762/3 M-9762/3 M-9753/1 Disease alpha heavy chain Bowen (C44._) chronic myeloproliferative (C42.1) deposition, immunoglobulin Di Guglielmo [obs] Franklin gamma heavy chain Hand-Schuller-Christian [obs] M-9762/3 M-9762/3 M-9762/3 M-9762/3 Differentiation adenocarcinoma with neuroendocrine carcinoma showing thymus-like carcinoma with neuroendocrine malignant peripheral nerve sheath tumor with rhabdomyoblastic malignant schwannoma with rhabdomyoblastic MPNST with glandular MPNST with mesenchymal MPNST with rhabdomyoblastic M-------M-9769/1 M-9760/3 M-9764/3 M-9754/3 M-9970/1 M-9768/1 M-9741/3 160 Heavy chain NOS alpha gamma mu Hodgkin (see Hodgkin disease) immunoglobulin deposition immunoproliferative, NOS immunoproliferative small intestinal (C17._) Letterer-Siwe lymphoproliferative, NOS lymphoproliferative, T-gamma mast cell, systemic tissue Alphabetic Index M-9762/3 M-9975/1 M-9960/3 M---------M-9540/1 M-9701/3 M-9764/3 M-9769/1 M-9741/3 M-9768/1 M-9540/1 Disease, continued mu heavy chain myeloproliferative, NOS (C42.1) myeloproliferative, chronic (C42.1) Paget (see Paget disease) Recklinghausen (except of bone) Sezary small intestinal, immunoproliferative (C17._) systemic light chain systemic tissue mast cell T-gamma lymphoproliferative von Recklinghausen (except of bone) Distal third of esophagus Diverticulum, Meckel (site of neoplasm) Dome, bladder C02.0 C02.0 C02.0 C01.9 Dorsal surface anterior tongue tongue, NOS tongue, anterior 2/3 tongue, base C48.1 Douglas pouch C24.0 C24.0 C24.0 C24.0 C24.0 C75.2 C24.0 C24.0 C24.0 C52.9 C24.0 C24.0 C22.1 C69.5 C69.5 C69.5 C25.3 C07.9 C25.3 C07.9 C08.1 C08.0 C49.3 C73.9 C08.0 C25.3 C57.7 Duct bile, NOS biliary, NOS choledochal common common bile craniopharyngeal cystic cystic bile extrahepatic bile Gartner hepatic hepatic bile intrahepatic bile lacrimal, NOS nasal lacrimal nasolacrimal pancreatic parotid gland Santorini Stensen sublingual gland submaxillary gland thoracic thyroglossal Wharton Wirsung Wolffian M-8500/3 M-8500/3 M-8503/0 M-8319/3 Carcinoma NOS Bellini (C64.9) collecting (C64.9) desmoplastic type sclerosing sweat (C44._) M-8500/3 M--------- cell carcinoma ectasia, mammary (see SNOMED) M-8500/3 M-8523/3 M-8523/3 M-8522/3 M-8522/3 M-9960/3 Disorder, chronic myeloproliferative M-9970/1 Disorder, lymphoproliferative, NOS M-9754/3 Disseminated Langerhans cell histiocytosis C15.5 C17.3 C67.1 M-8500/3 M-8319/3 M-8319/3 M-8514/3 M-8407/3 M-8523/3 M-8541/3 M-8523/3 M-8500/3 M-8523/3 Infiltrating adenocarcinoma (C50._) and colloid carcinoma (C50._) and cribriform carcinoma (C50._) and lobular carcinoma (C50._) and lobular carcinoma in situ (C50._) and mucinous carcinoma (C50._) and Paget disease, breast (C50._) and tubular carcinoma (C50._) carcinoma (C50._) mixed with other types of carcinoma (C50._) M-8407/3 M-8525/3 papillomatosis, subareolar (C50.0) renal carcinoma, collecting duct type (C64.9) sweat, carcinoma, sclerosing (C44._) terminal, adenocarcinoma M-9110/0 M-9110/3 M-9110/1 Wolffian adenoma carcinoma tumor M-8506/0 M-8319/3 M-8500/3 M-8522/3 M-8201/3 M-8201/2 M-8500/2 M-8522/3 M-8501/2 M-8201/2 M-8507/2 M-8503/2 M-8230/2 M-8500/2 M-8522/3 M-8154/3 M-8503/0 Ductal Carcinoma NOS and lobular (C50._) cribriform type (C50._) cribriform type, in situ (C50._) Carcinoma in situ NOS (C50._) and infiltrating lobular carcinoma (C50._) comedo type (C50._) cribriform type (C50._) micropapillary (C50._) papillary (C50._) solid type (C50._) intraepithelial neoplasia 3 (C50._) lobular and ductal carcinoma (C50._) mixed ductal-endocrine carcinoma (C25._) papilloma M-8521/3 Ductular carcinoma, infiltrating (C50._) adenocarcinoma, NOS adenocarcinoma, infiltrating (C50._) adenoma, NOS Bellini, carcinoma (C64.9) 161 Alphabetic Index C17.0 C70.9 Duodenum Dura, NOS C70.9 C70.0 C70.1 Dura mater NOS cranial spinal M-9413/0 Dysembryoplastic neuroepithelial tumor M--------- Dysgenesis, NOS (see SNOMED) M-9060/3 Dysgerminoma M--------M-8077/2 M--------M--------M-9275/0 M-8453/1 M--------M--------M-8470/1 M-9895/3 M-9985/3 M-9272/0 M-9272/0 M--------- Dysplasia NOS (see SNOMED) CIN III with severe (C53._) congenital, NOS (see SNOMED) fibrous, NOS (see SNOMED) florid osseous (C41._) intraductal papillary-mucinous tumor with moderate (C25._) mild (see SNOMED) moderate (see SNOMED) mucinous cystic tumor with moderate (C25._) multilineage, acute myeloid leukemia with multilineage, refractory cytopenia with periapical cemental (C41._) periapical cemento-osseous (C41._) severe (see SNOMED) M-8402/0 M-8413/3 M-8408/3 M-8408/0 M-8404/0 M-8200/0 M-8408/3 M-8408/0 M-8409/0 M-8409/3 M-8403/0 M-8403/3 Eccrine acrospiroma (C44._) adenocarcinoma (C44._) adenocarcinoma, papillary (C44._) adenoma, papillary (C44._) cystadenoma (C44._) dermal cylindroma (C44._) papillary adenocarcinoma (C44._) papillary adenoma (C44._) poroma (C44._) poroma, malignant (C44._) spiradenoma (C44._) spiradenoma, malignant (C44._) M-8242/1 M-8242/3 M--------M-8921/3 M--------M--------M-8587/0 ECL cell carcinoid, NOS ECL cell carcinoid, malignant Ectasia, mammary duct (see SNOMED) Ectomesenchymoma Ectopia, NOS (see SNOMED) Ectopic glial tissue (see SNOMED) Ectopic hamartomatous thymoma C62.0 Ectopic testis (site of neoplasm) M-8820/0 Elastofibroma C76.4 C44.6 C49.1 C47.1 C49.1 C49.1 C40.0 C47.1 C44.6 C49.1 C49.1 M-9493/0 Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) (C71.6) M-8727/0 Dysplastic nevus (C44._) M-9705/3 Dysproteinemia, peripheral T-cell lymphoma, Angioimmunoblastic Lymphadenopathy with (AILD) [obs] Elbow NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system connective tissue fibrous tissue joint peripheral nerve skin soft tissue subcutaneous tissue Element Sertoli-Leydig cell tumor, intermediate differentiation, with heterologous M-8634/3 Sertoli-Leydig cell tumor, poorly differentiated, with heterologous M-8634/1 Sertoli-Leydig cell tumor, retiform, with heterologous M-8588/3 spindle epithelial tumor with thymus-like M-8634/1 E Ear C44.2 C44.2 C49.0 C44.2 C30.1 C44.2 C30.1 C44.2 C44.2 NOS canal cartilage external inner lobule middle skin, NOS M-9101/3 Elements, choriocarcinoma combined with other germ cell M-8593/1 Elements, stromal tumor with minor sex cord (C56.9) M-8000/6 Embolus, tumor Earlobe M-8241/3 EC cell carcinoid M-9210/0 Ecchondroma (C40._, C41._) M-9210/1 Ecchondrosis (C40._, C41._) M-9070/3 M-8191/0 M-8902/3 162 Embryonal adenocarcinoma adenoma and alveolar rhabdomyosarcoma, mixed Alphabetic Index M-9070/3 M-9081/3 M-9101/3 M-9071/3 M-9072/3 Embryonal continued Carcinoma NOS and teratoma, mixed combined with choriocarcinoma infantile polyembryonal type Endometrioid, continued Adenofibroma M-8381/0 NOS M-8381/1 borderline malignancy M-8381/3 malignant M-8380/0 M-8380/1 M-8380/3 M-8380/3 adenoma, NOS adenoma, borderline malignancy carcinoma, NOS cystadenocarcinoma M-8981/3 M-8970/3 M--------- carcinosarcoma hepatoma (C22.0) rest, NOS (see SNOMED) M-8910/3 M-8902/3 M-8910/3 Rhabdomyosarcoma NOS and alveolar, mixed pleomorphic M-8381/0 M-8381/1 M-8381/3 Cystadenofibroma NOS borderline malignancy malignant M-8991/3 M-9080/3 sarcoma teratoma M-8380/0 M-8380/1 M-8380/1 M-8380/1 cystadenoma, NOS cystadenoma, borderline malignancy tumor, atypical proliferative tumor of low malignant potential M-8335/3 M-8343/3 M-9220/0 M--------M-8384/3 M-8482/3 Encapsulated follicular carcinoma (C73.9) Encapsulated papillary carcinoma (C73.9) Enchondroma (C40._, C41._) Endemic goiter (see SNOMED) Endocervical type adenocarcinoma Endocervical type mucinous adenocarcinoma C38.0 C53.0 C53.0 C53.0 Endocardium Endocervical canal Endocervical gland Endocervix C75.9 C75.8 C25.4 Endocrine gland, NOS glands, multiple pancreas M---------- Endometrioma (see SNOMED) M---------M---------M---------M-8931/3 Endometriosis NOS (see SNOMED) external (see SNOMED) internal (see SNOMED) stromal (C54.1) C54.1 Endometrium Endotheliomatous meningioma (C70._) Endovascular papillary angioendothelioma Enterochromaffin cell carcinoid Enterochromaffin-like cell carcinoid, NOS Enterochromaffin-like cell tumor, malignant M---------- Enterogenous cyst (see SNOMED) M-8157/1 Enteroglucagonoma, NOS M-8157/3 Enteroglucagonoma, malignant M-9531/0 M-9135/1 M-8241/3 M-8242/1 M-8242/3 M-8360/1 Endocrine adenomas, multiple M-8360/1 Endocrine adenomatosis M-8154/3 Endocrine-acinar carcinoma, mixed (C25._) M-8154/3 Endocrine-ductal carcinoma, mixed (C25._) M-9071/3 Endodermal sinus tumor M-8931/3 Endolymphatic stromal myosis (C54.1) M-8930/3 Endometrial sarcoma, NOS (C54.1) M-8280/3 M-8280/0 M-8280/3 Eosinophil adenocarcinoma (C75.1) adenoma (C75.1) carcinoma (C75.1) M-9752/1 Eosinophilic granuloma Ependyma C54.1 Endometrial stroma C71.5 Endometrial stromal nodule (C54.1) sarcoma, NOS (C54.1) sarcoma, high grade (C54.1) sarcoma, low grade (C54.1) M-9392/3 Ependymoblastoma (C71._) M-8930/0 M-8930/3 M-8930/3 M-8931/3 M-9391/3 M-9392/3 M-9391/3 M-9391/3 M-9391/3 M-9394/1 M-9393/3 M-9391/3 M-8931/3 Endometrial stromatosis Endometrioid Adenocarcinoma M-8380/3 NOS M-8383/3 ciliated cell variant M-8382/3 secretory variant 163 Ependymoma NOS (C71._) anaplastic (C71._) cellular (C71._) clear cell (C71._) epithelial (C71._) myxopapillary (C72.0) papillary (C71._) tanycytic (C71._) Alphabetic Index M-9383/1 Ependymoma-subependymoma, mixed (C71._) M--------- Ephelis (see SNOMED) C38.0 Epicardium M-8760/0 Epidermal and dermal nevus (C44._) M-8070/3 M-8560/3 M-8070/2 M-8076/2 M-8071/3 M-8072/3 M-8052/3 M-8073/3 M-8074/3 M-8051/3 Epidermoid carcinoma NOS and adenocarcinoma, mixed in situ, NOS in situ with questionable stromal invasion keratinizing large cell, nonkeratinizing papillary small cell, nonkeratinizing spindle cell verrucous M--------- Epidermoid cholesteatoma (see SNOMED) Epidermoid cyst (see SNOMED) C63.0 C72.9 Epididymis Epidural M--------- C10.1 C32.1 Epiglottis NOS (excludes anterior surface of epiglottis C10.1) anterior surface posterior surface M-9391/3 M-8452/1 M-9340/0 M-8585/1 M-8585/3 Epithelial ependymoma (C71.1) neoplasm, solid and papillary (C25._) odontogenic tumor, calcifying (C41._) thymoma, NOS (C37.9) thymoma, malignant (C37.9) C32.1 M-8010/0 M-8010/3 M-8588/3 M-8588/3 Tumor benign malignant spindle, with thymus-like differentiation spindle, with thymus-like element M-8562/3 Epithelial-myoepithelial carcinoma M-8770/3 M-8770/0 M-9133/1 M-9133/3 Epithelioid continued hemangioma leiomyoma leiomyosarcoma M-9052/3 M-9052/0 M-9052/3 Mesothelioma NOS benign malignant M-9540/3 M-8804/3 M-9105/3 MPNST sarcoma trophoblastic tumor M-8011/3 M-8100/0 M-8090/3 M-8011/0 M-8110/0 M-8096/0 M-8011/3 M-8410/0 M-8070/3 Epithelioma NOS adenoides cysticum (C44._) basal cell (C44._) benign calcifying, Malherbe (C44._) intraepidermal, Jadassohn (C44._) malignant sebaceous (C44._) squamous cell C77.3 Epitrochlear lymph node M--------M-9840/3 M-9950/3 M-9840/3 M-9840/3 M-9840/3 M-8080/2 Eruption cyst (see SNOMED) Erythremia, acute (C42.1) [obs] Erythremia, chronic (C42.1) [obs] Erythremic myelosis, NOS (C42.1) Erythremic myelosis, acute (C42.1) [obs] Erythroleukemia (C42.1) Erythroplasia, Queyrat (C60._) C77.1 C16.0 Esophageal lymph node Esophagogastric junction C15.9 C15.2 C15.0 C15.5 C15.5 C15.4 C15.3 C15.1 C15.3 Esophagus NOS abdominal cervical distal third lower third middle third proximal third thoracic upper third M--------- Esophagus, Barrett (see SNOMED) M-9962/3 Essential thrombocythemia (C42.1) M-9962/3 Essential thrombocythemia, hemorrhagic (C42.1) M-9522/3 Esthesioneuroblastoma (C30._) M-9521/3 Esthesioneurocytoma (C30._) M-9523/3 Esthesioneuroepithelioma (C30._) Epithelioid and spindle cell melanoma, mixed and spindle cell nevus (C44._) Cell M-8771/3 M-8771/0 M-8804/3 M-9042/3 M-9125/0 M-8891/0 M-8891/3 melanoma nevus (C44._) sarcoma synovial sarcoma C41.0 C31.1 C30.1 hemangioendothelioma, NOS hemangioendothelioma, malignant 164 Ethmoid bone Ethmoid sinus Eustachian tube Alphabetic Index M-9260/3 Ewing sarcoma (C40._, C41._) M-9260/3 Ewing tumor (C40._, C41._) M-9984/3 Excess blasts in transformation, refractory anemia with (RAEB-T) [obs] M-9983/3 Excess blasts, refractory anemia with C53.1 Exocervix M-8154/3 Exocrine and islet cell adenocarcinoma, mixed (C25._) M-8121/0 Exophytic sinonasal papilloma (C30.0, C31._) M--------M-9210/0 M-9210/0 Exostosis NOS (see SNOMED) cartilaginous (C40._, C41._) osteocartilaginous (C40._, C41._) C44.2 C44.2 C44.2 C44.3 C44.2 C51.9 C00.2 C00.1 C00.0 C44.3 C53.1 External auditory canal auditory meatus auricular canal cheek ear female genitalia lip, NOS lip, lower lip, upper nose os M--------M-8821/1 M-8693/1 M-8693/3 External endometriosis (see SNOMED) Extra-abdominal desmoid Extra-adrenal paraganglioma, NOS Extra-adrenal paraganglioma, malignant C72.9 C24.0 Extradural Extrahepatic bile duct Extraocular muscle Extrinsic larynx Eye C69.9 C44.1 C44.1 C44.1 C69.3 C69.4 C69.0 C69.6 C69.1 C69.1 C69.4 C69.6 C69.4 C44.3 C44.1 Eye, continued eyelid, lower eyelid, upper inner canthus intraocular iris lacrimal duct, NOS lacrimal duct, nasal lacrimal gland lacrimal sac lens, crystalline Meibomian gland muscle, extra-ocular nasal lacrimal duct nasolacrimal duct optic nerve orbit, NOS orbit, connective tissue orbit, soft tissue outer canthus palpebra retina retrobulbar tissue sclera uveal tract C69.4 Eyeball C44.1 C44.1 C44.1 Eyelid NOS lower upper F M-8542/3 Extramammary Paget disease (except Paget disease of bone) M-9734/3 Extramedullary plasmacytoma (not occurring in bone) C69.6 C32.1 C44.1 C44.1 C44.1 C69.4 C69.4 C69.5 C69.5 C69.5 C69.5 C69.4 C44.1 C69.6 C69.5 C69.5 C72.3 C69.6 C69.6 C69.6 C44.1 C44.1 C69.2 C69.6 C69.4 C69.4 NOS canthus, NOS canthus, inner canthus, outer choroid ciliary body conjunctiva connective tissue, orbit cornea, NOS cornea, limbus crystalline lens extraocular muscle eyeball eyebrow eyelid, NOS 165 M-------- FAB (see Leukemia, FAB) C76.0 C44.3 C49.0 C49.0 C41.0 C49.0 C49.0 C49.0 C77.0 C49.0 C49.0 C44.3 C49.0 C49.0 Face NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue bone (excludes mandible C41.1) connective tissue fatty tissue fibrous tissue lymph node muscle skeletal muscle skin soft tissue subcutaneous tissue C41.0 C77.0 C72.5 Facial bone lymph node nerve Alphabetic Index C57.0 C32.1 C32.1 Fallopian tube False cord False vocal cord C70.0 C70.0 C70.0 Falx NOS cerebelli cerebri M-8220/0 Familial polyposis coli (C18._) C49.9 C49.1 C49.2 Fascia NOS palmar plantar M-8813/0 Fascial fibroma M-8813/3 Fascial fibrosarcoma M--------M--------M--------- Fasciitis infiltrative (see SNOMED) nodular (see SNOMED) pseudosarcomatous (see SNOMED) Fat M-8880/0 M--------M-8880/0 C49.9 C49.4 C49.1 C49.1 C49.3 C49.6 C49.5 C49.2 C49.0 C49.0 C49.3 C49.0 C49.6 C49.2 C49.1 C49.5 C49.5 C49.1 C49.0 C49.2 C49.3 C49.5 C49.2 C49.2 C49.0 C49.2 C49.5 C49.0 C49.1 C49.0 C49.0 C49.2 C49.6 cell lipoma, fetal necrosis (see SNOMED) tumor, brown C10.9 C09.1 C09.9 Fauces, NOS Faucial pillar Faucial tonsil C57.9 C57.9 C51.9 C57.9 Female genital organs, NOS genital tract, NOS genitalia, external genitourinary tract, NOS C49.2 C77.4 C47.2 Femoral artery lymph node nerve C40.2 Femur M-8333/3 M-8333/0 M-8880/0 M-8881/0 M-8881/0 M-8903/0 Fetal adenocarcinoma (C73.9) adenoma (C73.9) fat cell lipoma lipoma, NOS lipomatosis rhabdomyoma C58.9 Fetal membranes M-9420/3 Fibrillary astrocytoma (C71._) Fatty tissue NOS abdominal wall antecubital space arm axilla back buttock calf cervical region cheek chest wall face flank foot forearm gluteal region groin hand head hip infraclavicular region inguinal region knee leg neck popliteal space sacrococcygeal region scalp shoulder supraclavicular region temple thigh trunk, NOS M-9010/0 M-9016/0 M-9011/0 M-9030/0 M-9012/0 Fibroadenoma NOS (C50._) giant (C50._) intracanalicular (C50._) juvenile (C50._) pericanalicular (C50._) M-9290/0 Fibroameloblastic odontoma (C41._) M-8857/3 M-9532/0 M-9182/3 M-8834/1 M-9220/3 M--------M-9271/0 M-9290/3 M-8093/3 M-8093/3 M--------M--------M-8093/3 M-8093/3 M-8391/0 M-8835/1 M-8890/0 M-8171/3 166 Fibroblastic liposarcoma meningioma (C70._) osteosarcoma (C40._, C41._) Fibroblastoma, giant cell Fibrochondrosarcoma (C40._, C41._) Fibrocystic disease, NOS (see SNOMED) Fibrodentinoma, ameloblastic (C41._) Fibrodentinosarcoma, ameloblastic (C41._) Fibroepithelial basal cell carcinoma (C44._) basal cell carcinoma, Pinkus type papilloma (see SNOMED) polyp (see SNOMED) Fibroepithelioma, NOS Fibroepithelioma of Pinkus type Fibrofolliculoma (C44._) Fibrohistiocytic tumor, plexiform Fibroid uterus (C55.9) Fibrolamellar hepatocellular carcinoma (C22.0) Alphabetic Index M-8851/0 Fibrolipoma M-8850/3 Fibroliposarcoma M-8810/0 M-9330/0 M-8810/1 M-9274/0 M-9274/0 M-9321/0 M-9241/0 M-8823/0 M-8813/0 M-8391/0 M-8821/1 M--------M-8811/0 M--------M-9321/0 M-9321/0 M-9322/0 M-9262/0 M-8391/0 M-8812/0 M-9322/0 M-8966/0 Fibroma NOS ameloblastic (C41._) cellular (C56.9) cementifying (C41._) cemento-ossifying (C41._) central odontogenic (C41._) chondromyxoid (C40._, C41._) desmoplastic fascial follicular (C44._) invasive juvenile aponeurotic (see SNOMED) myxoid nonossifying (see SNOMED) odontogenic, NOS (C41._) odontogenic, central (C41._) odontogenic, peripheral (C41._) ossifying (C41._) perifollicular (C44._) periosteal (C40._, C41._) peripheral odontogenic (C41._) renomedullary (C64.9) Fibromatosis M--------NOS (see SNOMED) M-8822/1 abdominal M-8821/1 aggressive M--------cicatricial (see SNOMED) M-8824/1 congenital generalized M-8822/1 mesenteric (C48.1) M--------musculo-aponeurotic (see SNOMED) M--------pseudosarcomatous M-8822/1 retroperitoneal (C48.0) M-8890/0 M-8842/0 M-8852/0 M-8811/0 M-8811/3 M-9290/0 M-9290/3 M-9262/0 Fibromyoma Fibromyxoid tumor, ossifying Fibromyxolipoma Fibromyxoma Fibromyxosarcoma Fibro-odontoma, ameloblastic (C41._) Fibro-odontosarcoma, ameloblastic Fibro-osteoma (C40._, C41._) M-8810/3 M-9330/3 M-8814/3 M-8813/3 M-8814/3 M-9330/3 M-8812/3 Fibrosarcoma NOS ameloblastic (C41._) congenital fascial infantile odontogenic (C41._) periosteal (C40._, C41._) M--------M--------M--------- Fibrosclerosis (see SNOMED) Fibrosing adenomatosis (see SNOMED) Fibrosing adenosis (see SNOMED) 167 M--------M-8141/3 M-8832/0 Fibrosis NOS (see SNOMED) carcinoma with productive subepidermal nodular (C44._) M-9420/3 M--------M--------- Fibrous astrocytoma (C71._) defect, metaphyseal (see SNOMED) dysplasia, NOS (see SNOMED) M-8830/0 M-8836/1 M-8830/1 M-8830/0 M-8830/3 M-9252/0 Histiocytoma NOS angiomatoid atypical benign malignant tendon sheath (C49.0) M-9532/0 meningioma (C70._) M-9051/3 M-9051/0 M-9051/3 Mesothelioma NOS benign malignant M-9160/0 M--------M-9041/3 papule of nose (C44.3) [obs] polyp (see SNOMED) synovial sarcoma, monophasic C49.9 C49.4 C49.2 C49.1 C49.1 C49.3 C49.6 C49.5 C49.2 C49.0 C49.0 C49.3 C49.3 C49.0 C49.1 C49.0 C49.1 C49.6 C49.2 C49.1 C49.0 C49.5 C49.5 C49.1 C49.0 C49.2 C49.2 C49.3 C49.5 C49.2 C49.2 C49.0 C49.5 Tissue NOS abdominal wall ankle antecubital space arm axilla back buttock calf cervical region cheek chest chest wall chin elbow face finger flank foot forearm forehead gluteal region groin hand head heel hip infraclavicular region inguinal region knee leg neck perineum Alphabetic Index C49.2 C49.0 C49.5 C49.0 C49.3 C49.1 C49.0 C49.0 C49.2 C49.3 C49.1 C49.2 C49.6 C49.4 C49.1 M-8815/0 M-8815/0 M-8815/3 Fibrous, continued Tissue, continued popliteal space pterygoid fossa sacrococcygeal region scalp scapular region shoulder supraclavicular region temple thigh thoracic wall thumb toe trunk, NOS umbilicus wrist C49.6 C49.6 C49.6 M-8212/0 Flat adenoma C04.9 C04.0 C04.1 Fibroxanthoma NOS atypical malignant C40.2 C72.0 Fibula Filum terminale C76.4 C44.6 C49.1 C47.1 C40.1 C49.1 C49.1 C49.1 C44.6 C47.1 C49.1 C44.6 C49.1 C49.1 C49.1 C49.1 Finger NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system bone connective tissue fibrous tissue muscle nail peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath C76.7 C44.5 C49.6 C49.6 C47.6 C49.6 C49.6 C49.6 C49.6 C47.6 C49.6 C44.5 C49.6 Flank NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue Floor of mouth NOS anterior lateral M--------- Florid adenosis (see SNOMED) M-9275/0 Florid osseous dysplasia (C41._) M--------- Focal nodular hyperplasia (see SNOMED) C13.1 C32.1 C13.1 C09.1 Fold aryepiglottic, NOS (excludes laryngeal aspect of aryepiglottic fold C32.1) aryepiglottic, hypopharyngeal aspect aryepiglottic, laryngeal aspect arytenoid glossopalatine M-8330/3 M-8332/3 M-8332/3 M-8331/3 Follicular Adenocarcinoma NOS (C73.9) moderately differentiated (C73.9) trabecular (C73.9) well differentiated (C73.9) C13.1 Tumor localized solitary solitary, malignant M-8830/0 M-8830/1 M-8830/3 Flank, continued subcutaneous tissue tendon tendon sheath M-8330/0 M-8330/1 M-8290/0 Adenoma NOS (C73.9) atypical (C73.9) oxyphilic cell (C73.9) M-8340/3 M-8340/3 and papillary adenocarcinoma (C73.9) and papillary carcinoma (C73.9) M-8330/3 M-8335/3 M-8335/3 M-8332/3 M-8290/3 M-8332/3 M-8331/3 Carcinoma NOS (C73.9) encapsulated (C73.9) minimally invasive (C73.9) moderately differentiated (C73.9) oxyphilic cell (C73.9) trabecular (C73.9) well differentiated (C73.9) M--------M-9758/3 M-9758/3 M-8391/0 M--------M--------M-8340/3 M-8340/3 cyst, jaw (see SNOMED) dendritic cell sarcoma dendritic cell tumor fibroma (C44._) keratosis, inverted (see SNOMED) lymphoma (see lymphoma, malignant, follicular) variant, papillary adenocarcinoma (C73.9) variant, papillary carcinoma (C73.9) M-8346/3 Follicular-medullary carcinoma, mixed (C73.9) M-8641/0 Folliculome lipidique (C56.9) 168 Alphabetic Index C76.5 C44.7 C49.2 C49.2 C47.2 C40.3 C49.2 C49.2 C49.2 C40.3 C49.2 C47.2 C40.3 C49.2 C44.7 C49.2 C44.7 C49.2 C49.2 C49.2 Foot NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue joint muscle peripheral nerve phalanx skeletal muscle skin soft tissue sole subcutaneous tissue tendon tendon sheath M--------- Fordyce disease (see SNOMED) C76.4 C44.6 C49.1 C49.1 C47.1 C40.0 C49.1 C49.1 C49.1 C49.1 C47.1 C49.1 C44.6 C49.1 C49.1 C49.1 C49.1 Forearm NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath C44.3 C44.3 C49.0 C47.0 C49.0 C49.0 C47.0 C44.3 C49.0 C49.0 Forehead NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system connective tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue C60.0 C11.3 C52.9 Foreskin Fornix, pharyngeal Fornix, vagina C71.9 C71.9 Fossa Cranial NOS anterior C71.9 C71.9 Fossa, continued Cranial, continued middle posterior C76.3 C75.1 C49.0 C12.9 C11.2 C09.0 ischiorectal pituitary pterygoid, NOS pyriform Rosenmuller tonsillar C51.9 C71.7 Fourchette Fourth ventricle M-9762/3 Franklin disease M--------M-8742/2 M-8742/3 Freckle NOS (see SNOMED) Hutchinson melanotic, NOS (C44._) malignant melanoma in Hutchinson melanotic (C44._) C00.5 C02.2 C00.5 C00.4 C00.3 Frenulum labii, NOS linguae lip, NOS lower lip upper lip C41.0 C71.1 C71.1 C31.2 Frontal bone lobe pole sinus C16.1 C16.1 C54.3 Fundus gastric stomach uteri M-8121/0 Fungiform sinonasal papilloma (C30.0, C31._) M-9700/3 Fungoides, mycosis (C44._) M-8043/3 Fusiform cell, small cell carcinoma M-8004/3 Fusiform cell type, malignant tumor G M-8153/1 G cell tumor, NOS M-8153/3 G cell tumor, malignant C23.9 Gallbladder M-9762/3 Gamma heavy chain disease M-9765/1 Gammopathy, monoclonal, NOS M-9765/1 Gammopathy, monoclonal, of undetermined significance 169 Alphabetic Index C47.9 C71.0 Ganglia, NOS Ganglia, basal M-8683/0 Gangliocytic paraganglioma (C17.0) M-9492/0 Gangliocytoma M-9493/0 Gangliocytoma of cerebellum, dysplastic (Lhermitte-Duclos) (C71.6) M-9505/1 M-9505/3 M-9412/1 Ganglioglioma NOS anaplastic desmoplastic infantile M--------- Ganglion cyst (see SNOMED) Genitalia, female, external Genitourinary tract, female, NOS Genitourinary tract, male, NOS Gastric (see also stomach) NOS antrum cardia corpus fundus lymph node M-8153/1 M-8153/3 M-8153/1 M-8153/3 Gastrin cell tumor Gastrin cell tumor, malignant Gastrinoma, NOS Gastrinoma, malignant C49.2 C16.0 Gastrocnemius muscle Gastroesophageal junction Gastrointestinal stromal sarcoma Tumor NOS benign malignant uncertain malignant potential Gastrointestinal tract, NOS M-8480/3 M-8480/3 M-9411/3 M-9411/3 M-8824/1 M-9754/3 M-8905/0 Gelatinous adenocarcinoma [obs] Gelatinous carcinoma [obs] Gemistocytic astrocytoma (C71._) Gemistocytoma (C71._) Generalized fibromatosis, congenital Generalized Langerhans cell histiocytosis Genital rhabdomyoma (C51._, C52.9) M--------- Giant condyloma acuminatum (see SNOMED) congenital nevus, intermediate and (C44._) fibroadenoma (C50._) osteoid osteoma (C40._, C41._) pigmented nevus, NOS (C44._) pigmented nevus, malignant melanoma in (C44._) rugal hypertrophy (see SNOMED) M-8030/3 M-9160/0 M-9384/1 M-8031/3 M-8035/3 M-8834/1 M-9441/3 M--------M--------M-8802/3 M-9250/3 M--------- Giant cell and spindle cell carcinoma angiofibroma astrocytoma, subependymal (C71._) carcinoma carcinoma with osteoclast-like fibroblastoma glioblastoma (C71._) granuloma, central (see SNOMED) reparative granuloma (see SNOMED) sarcoma (except of bone M-9250/3) sarcoma of bone (C40._, C41._) tendon sheath (see SNOMED) M-9250/1 M-9250/3 M-9230/0 M-9251/1 M-9251/3 M-9252/0 M-9252/3 M-9252/0 M-9252/3 Tumor bone, NOS (C40._, C41._) bone, malignant (C40._, C41._) chondromatous (C40._, C41._) soft parts, NOS soft parts, malignant tendon sheath (C49._) tendon sheath, malignant (C49._) tenosynovial (C49._) tenosynovial, malignant (C49._) M-8003/3 type, malignant tumor M--------M-8761/1 M-9016/0 M-9200/0 M-8761/1 M-8761/3 M-8936/1 Gastrointestinal autonomic nerve tumor M-8936/1 Gastrointestinal pacemaker cell tumor C26.9 Germ cell elements, choriocarcinoma combined with other neoplasia, intratubular (C62._) tumor, NOS tumor, mixed tumor, nonseminomatous (C62._) M-9064/2 Germ cells, intratubular malignant (C62._) M-9064/3 Germinoma M-9302/0 Ghost cell tumor, odontogenic (C41._) Gartner duct C16.9 C16.3 C16.0 C16.2 C16.1 C77.2 M-8936/1 M-8936/0 M-8936/3 M-8936/1 C51.9 C57.9 C63.9 M-9064/2 M-9064/3 M-9085/3 M-9065/3 Ganglioneuroblastoma Ganglioneuroma Ganglioneuromatosis Ganglionic differentiation, rhabdomyosarcoma with M-8936/1 GANT M-8936/3 Genital organs, female, NOS organs, male, NOS tract, female, NOS tract, male, NOS M-9101/3 M-9490/3 M-9490/0 M-9491/0 M-8921/3 C52.9 C57.9 C63.9 C57.9 C63.9 M-9275/0 Gigantiform cementoma (C41._) 170 Alphabetic Index C03.9 C03.1 C03.1 C03.0 C03.0 Gingiva NOS lower mandibular maxillary upper M--------M--------- Gingival cyst, NOS (see SNOMED) Gingival cyst, odontogenic (see SNOMED) C40.0 Girdle, shoulder C08.1 C08.1 C08.0 C08.0 C08.0 C74.9 C73.9 C68.0 Gland adrenal Bartholin ceruminal Cowper endocervical endocrine, NOS endocrine, multiple endometrial lacrimal mammary Meibomian Nabothian parathyroid paraurethral parotid parotid, duct pineal pituitary prostate salivary, NOS (excludes minor salivary gland, NOS C06.9; see coding guidelines page 38 and note under C08) salivary, major, NOS salivary, minor, NOS (see coding guidelines, page 38 and note under C08) sublingual sublingual, duct submandibular submaxillary submaxillary, duct suprarenal thyroid urethral C75.8 Glands, endocrine, multiple C08.9 C06.9 Glandular, continued metaplasia (see SNOMED) papilloma papilloma, squamous cell and, mixed papillomatosis C60.1 Glans penis M-8015/3 Glassy cell carcinoma M--------- Glial heterotopia, nasal (see SNOMED) GIST M-8936/1 NOS M-8936/0 benign M-8936/3 malignant C74.9 C51.0 C44.2 C68.0 C53.0 C75.9 C75.8 C54.1 C69.5 C50.9 C44.1 C53.0 C75.0 C68.1 C07.9 C07.9 C75.3 C75.1 C61.9 C08.9 M--------M-8260/0 M-8560/0 M-8264/0 M-9440/3 M-9441/3 M-9440/3 M-9442/3 Glioblastoma NOS (C71._) giant cell (C71._) multiforme (C71._) with sarcomatous component (C71._) M-9442/1 Gliofibroma (C71._) M-9380/3 M-9400/3 M-9444/1 M-9444/1 M-9380/3 M-9382/3 M--------M-9383/1 Glioma NOS (except nasal glioma—not neoplastic) (C71._) astrocytic (C71._) chordoid (C71._) chordoid, third ventricle (C71.5) malignant (C71._) mixed (C71._) nasal (see SNOMED) subependymal (C71._) M-9381/3 Gliomatosis cerebri (C71._) M-9505/1 Glioneuroma [obs] M-9442/3 Gliosarcoma (C71._) C71.0 Globus pallidus Glomangioma Glomangiomyoma Glomangiosarcoma Glomerulosa cell adrenal cortical adenoma (C74.0) M-8710/3 Glomoid sarcoma M-8712/0 M-8713/0 M-8710/3 M-8374/0 C75.5 C75.5 Glomus, coccygeal Glomus jugulare M-8690/1 M-8711/0 M-8711/3 Glomus jugulare tumor, NOS (C75.5) tumor, NOS tumor, malignant C09.1 C72.5 C32.0 Glossopalatine fold Glossopharyngeal nerve Glottis M-8152/1 Glucagonoma, NOS (C25._) M-8152/3 Glucagonoma, malignant (C25._) Glandular M--------and stromal hyperplasia (see SNOMED) M-9540/3 differentiation, MPNST with glandular M--------hyperplasia (see SNOMED) M-8148/2 intraepithelial neoplasia, grade III C76.3 C44.5 C49.5 171 Gluteal region NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) Alphabetic Index C49.5 C47.5 C49.5 C49.5 C49.5 C49.5 C47.5 C49.5 C44.5 C49.5 C49.5 Gluteal region, continued adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C49.5 Gluteus maximus muscle M-8320/3 M-8320/3 M-9580/0 M-9580/3 M-9580/0 M-9580/3 M-9582/0 M-9831/1 Granular lymphocytosis, T-cell large M--------- Granulation tissue type hemangioma (see SNOMED) M-9930/3 Granulocytic sarcoma M-8904/0 Glycogenic rhabdomyoma M-8315/3 Glycogen-rich carcinoma (C50._) M--------M--------M-9752/1 M--------M-9661/3 M--------M--------M--------M--------- Goblet cell carcinoid type, bronchiolo-alveolar carcinoma (C34._) M-8254/3 type, bronchiolo-alveolar carcinoma, Clara cell and (C34._) M-8254/3 type, bronchiolo-alveolar carcinoma, type II pneumocyte and (C34._) M-8243/3 M-8253/3 M--------M--------M--------M--------- Goiter NOS (see SNOMED) adenomatous (see SNOMED) colloid (see SNOMED) endemic (see SNOMED) M-8590/1 M-8590/1 M-8591/1 M-8592/1 Gonadal stromal tumor NOS and sex cord tumor sex cord, incompletely differentiated sex cord, mixed forms M-8077/2 M-8077/2 M-8148/2 M-8077/2 M-8077/2 M-8077/2 Granuloma NOS (see SNOMED) central giant cell (see SNOMED) eosinophilic giant cell reparative (see SNOMED) Hodgkin plasma cell (see SNOMED) pyogenic (see SNOMED) reticulohistiocytic (see SNOMED) sarcoid (see SNOMED) M-9751/1 Granulomatosis, Langerhans cell, NOS M-9752/1 Granulomatosis, Langerhans cell, unifocal M-9766/1 Granulomatosis, lymphoid M-8620/3 M-8620/1 M-8620/1 M-8622/1 M-8620/3 M-8620/3 Granulosa cell carcinoma (C56.9) Tumor NOS (C56.9) adult type (C56.9) juvenile (C56.9) malignant (C56.9) sarcomatoid (C56.9) M-8621/1 Granulosa cell-theca cell tumor (C56.9) M-8312/3 Grawitz tumor (C64.9) [obs] M-9073/1 Gonadoblastoma M-9073/1 Gonocytoma M------/-1 M------/-2 M------/-3 M------/-4 M------/-9 Granular cell adenocarcinoma carcinoma myoblastoma, NOS myoblastoma, malignant tumor, NOS tumor, malignant tumor, sellar region (C75.1) Grade (see grading code, page 35) I II III IV not determined, not stated or not applicable C16.6 C76.3 C44.5 C49.5 C49.5 C47.5 C49.5 C49.5 C49.5 C77.4 C47.5 C44.5 C49.5 C49.5 Grade III anal intraepithelial neoplasia (C21.1) cervical intraepithelial neoplasia (C53._) glandular intraepithelial neoplasia squamous intraepithelial neoplasia vaginal intraepithelial neoplasia (C52._) vulvar intraepithelial neoplasia (C51._) 172 Greater curvature of stomach, NOS (not classifiable to C16.0 to C16.4) Groin NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue lymph node peripheral nerve skin soft tissue subcutaneous tissue Alphabetic Index C03.9 C03.1 C03.0 Gum NOS lower upper M-8632/1 Gynandroblastoma (C56.9) M--------- Gynecomastia (see SNOMED) H M-9940/3 Hairy cell leukemia (C42.1) M-8720/0 Hairy nevus (C44._) M-8723/0 Halo nevus (C44._) M--------M--------M--------- Hamartoma NOS (see SNOMED) angiomatous lymphoid (see SNOMED) mesenchymal (see SNOMED) M-8587/0 Hamartomatous thymoma, ectopic C76.4 C44.6 C49.1 C49.1 C47.1 C40.1 C49.1 C49.1 C49.1 C40.1 C49.1 C47.1 C40.1 C49.1 C44.6 C49.1 C49.1 C49.1 C49.1 Hand NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue joint muscle peripheral nerve phalanx skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath Hard palate Hard palate and soft palate, junction C76.0 C44.4 C49.0 C49.0 C47.0 C49.0 C49.0 C49.0 C77.0 C49.0 C47.0 Head NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue lymph node muscle peripheral nerve Head, continued skeletal muscle skin, NOS soft tissue subcutaneous tissue C25.0 C38.0 Head of pancreas Heart M-9762/3 M-9762/3 M-9762/3 M-9762/3 Heavy chain disease NOS alpha gamma mu C76.5 C44.7 C49.2 C47.2 C40.3 C49.2 C49.2 C47.2 C44.7 C49.2 C49.2 C49.2 Heel NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system bone connective tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue tendon sheath C44.2 Helix M-9535/0 Hemangioblastic meningioma (C70._) [obs] M-9161/1 Hemangioblastoma M-9130/3 Hemangioendothelial sarcoma M-9753/1 Hand-Schuller-Christian disease [obs] C05.0 C05.8 C49.0 C44.4 C49.0 C49.0 173 M-9130/1 M-9130/0 M-9133/1 M-9133/3 M-9130/1 M-9130/3 M-9136/1 Hemangioendothelioma NOS benign epithelioid, NOS epithelioid, malignant Kaposiform malignant spindle cell M-9120/0 M-9161/0 M-9123/0 M-9131/0 M-9121/0 M-9125/0 M--------M-9125/0 M-9131/0 M-9132/0 M-9131/0 M-9131/0 M-9123/0 M-8832/0 M-9131/0 M-9122/0 M-9142/0 Hemangioma NOS acquired tufted arteriovenous capillary cavernous epithelioid granulation tissue type (see SNOMED) histiocytoid infantile intramuscular juvenile plexiform racemose sclerosing (C44._) simplex venous verrucous keratotic Alphabetic Index Hemangiomatosis, NOS (see SNOMED) Hemangiomatosis, systemic (see SNOMED) M-9150/1 Hemangiopericytic meningioma (C70._) [obs] M--------M--------- M-9150/1 M-9150/0 M-9150/3 Heterologous elements Sertoli-Leydig cell tumor M-8634/1 intermediate differentiation, with M-8634/3 poorly differentiated, with M-8634/1 retiform, with Hemangiopericytoma NOS benign malignant M--------M--------- M-8880/0 Hibernoma M-8402/3 Hidradenocarcinoma (C44._) M-9120/3 Hemangiosarcoma M--------- Hematoma, NOS (see SNOMED) C42.4 C71.0 M-8400/0 M-8402/0 M-8402/0 M-8402/3 M-8405/0 M-8405/0 Hematopoietic system, NOS Hemisphere, cerebral M-9175/0 Hemolymphangioma M-9140/3 M-9962/3 M-9962/3 Hemorrhagic sarcoma, multiple thrombocythemia, essential (C42.1) thrombocythemia, idiopathic (C42.1) C22.0 C24.0 C24.0 C18.3 C77.2 Hepatic NOS bile duct duct flexure of colon lymph node Hilar lymph node NOS pulmonary splenic C34.0 Hilus of lung Hip C76.5 C44.7 C49.2 C49.2 C47.2 C41.4 C49.2 C49.2 C49.2 C41.4 C47.2 C44.7 C49.2 C49.2 C49.2 C49.2 Hepatocellular and bile duct carcinoma, mixed (C22.0) M-8170/0 adenoma (C22.0) Carcinoma NOS (C22.0) and cholangiocarcinoma, combined (C22.0) clear cell type (C22.0) fibrolamellar (C22.0) pleomorphic type (C22.0) sarcomatoid (C22.0) scirrhous (C22.0) spindle cell variant (C22.0) M-8180/3 Hepatocholangiocarcinoma (C22.0) Hepatoid M-8576/3 adenocarcinoma M-8576/3 carcinoma M-9071/3 yolk sac tumor M-8170/3 M-8170/0 M-8970/3 M-8170/3 C77.1 C77.1 C77.2 M-8660/0 Hilus cell tumor (C56.9) M-8180/3 M-8174/3 M-8171/3 M-8175/3 M-8173/3 M-8172/3 M-8173/3 Hidradenoma NOS (C44._) clear cell (C44._) nodular (C44._) nodular, malignant (C44._) papillary (C44._) papilliferum (C44._) M-8404/0 Hidrocystoma (C44._) M-8660/0 Hilar cell tumor (C56.9) M-8172/3 Hepatic carcinoma, sclerosing (C22.0) M-8970/3 Hepatoblastoma (C22.0) M-8170/3 Hepatocarcinoma (C22.0) M-8170/3 M-8180/3 Heterotopia, NOS (see SNOMED) Heterotopia, nasal glial (see SNOMED) NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue joint peripheral nerve skin soft tissue subcutaneous tissue tendon tendon sheath C71.2 Hippocampus M-9680/3 M-9755/3 M-9750/3 M-9755/3 Histiocytic lymphoma, NOS (see also lymphoma) lymphoma, true medullary reticulosis [obs] sarcoma M-9125/0 Histiocytoid hemangioma Hepatoma NOS (C22.0) benign (C22.0) embryonal (C22.0) malignant (C22.0) 174 Alphabetic Index M-8831/0 M-8832/0 M-8831/0 Histiocytoma NOS (C44._) cutaneous, NOS (C44._) deep M-8830/0 M-8836/1 M-8830/1 M-8830/0 M-8830/3 M-9252/0 Fibrous NOS angiomatoid atypical benign malignant tendon sheath (C49._) M-8831/0 juvenile M------M-9751/1 M-9754/3 M-9754/3 M-9752/1 M-9753/1 M-9753/1 M-9752/1 M-9750/3 M--------M-9751/1 M-9754/3 M-9650/3 M-9651/3 M-9651/3 M-9651/3 M-9663/3 M-9667/3 M-9665/3 M-9665/3 M-9667/3 M-9663/3 M-9664/3 M-9665/3 M-9667/3 M-9653/3 M-9654/3 M-9655/3 M-9651/3 M-9652/3 Lymphocyte depletion NOS depletion, reticular diffuse fibrosis M-9659/3 M-9651/3 M-9652/3 M-9659/3 lymphocyte predominance, nodular lymphocyte-rich mixed cellularity, NOS nodular lymphocyte predominance M-9663/3 M-9664/3 M-9665/3 M-9667/3 Nodular sclerosis NOS cellular phase grade 1 grade 2 Hodgkin paragranuloma, NOS [obs] Hodgkin paragranuloma, nodular [obs] Hodgkin sarcoma [obs] Horn formation, squamous cell carcinoma with M-9827/3 HTLV-1 positive, adult T-cell leukemia/lymphoma (includes all variants) M-9659/3 M-9659/3 M-9662/3 M-8078/3 malignant sinus, with massive lymphadenopathy (see SNOMED) X, NOS [obs] X, acute progressive Hodgkin disease (see also Hodgkin lymphoma) NOS lymphocyte predominance, NOS [obs] lymphocyte predominance, diffuse [obs] lymphocytic-histiocytic predominance [obs] C40.0 Humerus M-8290/3 M-8290/0 M-8290/3 M-8290/0 Hurthle cell adenocarcinoma (C73.9) adenoma (C73.9) carcinoma (C73.9) tumor (C73.9) M-8742/2 Hutchinson melanotic freckle, NOS (C44._) M-8742/3 Hutchinson melanotic freckle, malignant melanoma in (C44._) M-8336/0 Hyalinizing trabecular adenoma (C73.9) M-9100/0 Hydatid mole (C58.9) Nodular sclerosis NOS lymphocyte depletion lymphocyte predominance mixed cellularity syncytial variant M-9100/0 M-9100/0 M-9100/1 M-9100/1 M-9103/0 M-9661/3 Hodgkin granuloma [obs] M-9650/3 M-9596/3 M-9653/3 M-9655/3 M-9654/3 Histiocytosis NOS (see SNOMED) Langerhans cell NOS disseminated generalized mono-ostotic multifocal poly-ostotic unifocal Hodgkin lymphoma, classical, continued nodular sclerosis, NOS nodular sclerosis, cellular phase nodular sclerosis, grade 1 nodular sclerosis, grade 2 Hodgkin lymphoma NOS and non-Hodgkin lymphoma, composite Hydatidiform mole NOS (C58.9) complete (C58.9) invasive (C58.9) malignant (C58.9) partial (C58.9) M-9173/0 Hygroma, NOS M-9173/0 Hygroma, cystic Classical lymphocyte depletion, NOS lymphocyte depletion, diffuse fibrosis lymphocyte depletion, reticular lymphocyte-rich mixed cellularity, NOS C52.9 C41.0 Hymen Hyoid bone M-9964/3 Hypereosinophilic syndrome M-8311/1 Hypernephroid tumor [obs] M-8312/3 Hypernephroma (C64.9) [obs] 175 Alphabetic Index Hyperplasia M--------NOS (see SNOMED) M--------adenomatous (see SNOMED) M--------adenomyomatous (see SNOMED) M--------angiofollicular, benign (see SNOMED) M--------atypical (see SNOMED) M--------glandular (see SNOMED) M--------glandular and stromal (see SNOMED) M--------lobular (see SNOMED) M--------lymphoid, NOS (see SNOMED) M--------nodular, NOS (see SNOMED) M--------nodular focal (see SNOMED) M--------papilliferous (see SNOMED) M--------pseudoepitheliomatous (see SNOMED) M--------stromal (see SNOMED) M--------stromal and glandular (see SNOMED) M-9080/3 Immature teratoma, NOS M-9080/3 Immature teratoma, malignant M-9767/1 Immunoblastic lymphadenopathy (IBL)[obs] M-9684/3 Immunoblastic sarcoma [obs] M-9671/3 Immunocytoma [obs] M-9769/1 Immunoglobulin deposition disease M--------- Hyperplastic polyp (see SNOMED) M-8213/0 Hyperplastic and adenomatous polyp, mixed (C18._) M--------- Hyperplastic scar (see SNOMED) M-8508/3 Hypersecretory carcinoma, cystic (C50._) M--------- Hyperthecosis (see SNOMED) M--------- Hypertrophy, NOS (see SNOMED) M--------- Hypertrophy, giant rugal (see SNOMED) M-8140/2 M-8210/2 M-8210/2 M-8210/2 M-8210/2 M-8263/2 M-8261/2 C77.5 C72.5 C13.1 C13.9 C13.9 C13.2 C75.1 C71.0 M-9766/1 M-9760/3 M-9764/3 M-9766/1 M-9764/3 M-------/2 In situ (see behavior code, page 31) Hypogastric lymph node Hypoglossal nerve Hypopharyngeal aspect of aryepiglottic fold Hypopharyngeal wall Hypopharynx, NOS Hypopharynx, posterior wall Hypophysis Hypothalamus Idiopathic myelofibrosis, chronic thrombocythemia (C42.1) thrombocythemia, hemorrhagic (C42.1) C18.0 C18.0 C77.2 C17.2 Ileocecal junction Ileocecal valve Ileocolic lymph node Ileum (excludes ileocecal valve C18.0) C49.5 C77.5 C49.5 C49.4 C41.4 In situ (see coding guidelines, page 31) Adenocarcinoma NOS in a polyp, NOS in adenomatous polyp in polypoid adenoma in tubular adenoma in tubulovillous adenoma in villous adenoma M-8010/2 M-8070/2 M-8210/2 M-8210/2 Carcinoma NOS epidermoid, NOS in a polyp, NOS in adenomatous polyp M-8201/2 cribriform carcinoma (C50._) M-8500/2 M-8522/3 M-8501/2 M-8201/2 M-8507/2 M-8503/2 M-8230/2 I M-9961/3 M-9962/3 M-9962/3 Immunoproliferative angiocentric lesion disease, NOS disease, small intestinal (C17._) lesion, angiocentric small intestinal disease (C17._) M-8070/2 M-8076/2 Ductal carcinoma NOS (C50._) and infiltrating lobular carcinoma (C50._) comedo type (C50._) cribriform type (C50._) micropapillary (C50._) papillary (C50._) solid type (C50._) epidermoid carcinoma, NOS epidermoid carcinoma with questionable stromal invasion M-8520/2 M-8522/3 M-8522/2 Lobular carcinoma NOS (C50._) and infiltrating duct (C50._) and intraductal carcinoma (C50._) Iliac artery lymph node vein M-8720/2 M-8050/2 M-8052/2 melanoma papillary carcinoma papillary squamous cell carcinoma Iliopsoas muscle Ilium M-8070/2 M-8052/2 M-8076/2 Squamous cell carcinoma NOS papillary with questionable stromal invasion (C53._) 176 Alphabetic Index M-8120/2 transitional cell carcinoma M-8591/1 Incompletely differentiated sex cordgonadal stromal tumor M-8254/3 Indeterminate type bronchiolo-alveolar carcinoma (C34._) M-9412/1 Infancy, desmoplastic astrocytoma of M-9412/1 M-9071/3 M-8814/3 M-9412/1 M-9131/0 M-8824/1 Infantile astrocytoma, desmoplastic (C71._) embryonal carcinoma fibrosarcoma ganglioglioma, desmoplastic hemangioma myofibromatosis C77.5 C77.2 C49.4 Inferior epigastric lymph node mesenteric lymph node vena cava M-8503/3 M-8856/0 Infiltrating and papillary adenocarcinoma (C50._) angiolipoma M-8092/3 M-8092/3 M-8092/3 M-8500/3 M-8523/3 M-8523/3 M-8522/3 M-8522/3 M-8523/3 M-8523/3 M-8500/3 M-8541/3 M-8523/3 M-8521/3 M-8856/0 M-8520/3 M-8522/3 M-8524/3 Basal cell carcinoma NOS (C44._) non-sclerosing (C44._) sclerosing (C44._) Duct adenocarcinoma (C50._) and colloid carcinoma (C50._) and cribriform carcinoma (C50._) and lobular carcinoma (C50._) and lobular carcinoma in situ (C50._) and mucinous carcinoma (C50._) and tubular carcinoma (C50._) carcinoma (C50._) carcinoma and Paget disease, breast (C50._) mixed with other types of carcinoma (C50._) ductular carcinoma (C50._) lipoma Lobular carcinoma, NOS (C50._) carcinoma and ductal carcinoma in situ (C50._) mixed with other types of carcinoma (C50._) M-8503/3 papillary adenocarcinoma M-------- Infiltrative fasciitis (see SNOMED) M-8530/3 M-8530/3 M-8851/3 M-8825/1 M--------M--------- Inflammatory adenocarcinoma (C50._) carcinoma (C50._) liposarcoma myofibroblastic tumor polyp (see SNOMED) pseudotumor (see SNOMED) C77.3 Infraclavicular lymph node C76.1 C44.5 C49.3 C49.3 C47.3 C49.3 C49.3 C49.3 C77.3 C47.3 C44.5 C49.3 C49.3 Infraclavicular region NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue lymph node peripheral nerve skin soft tissue subcutaneous tissue C71.7 C77.4 Infratentorial brain, NOS (see also brain) Inguinal lymph node C76.3 C44.5 C49.5 C49.5 C47.5 C49.5 C49.5 C49.5 C77.4 C47.5 C44.5 C49.5 C49.5 Inguinal region NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue lymph node peripheral nerve skin soft tissue subcutaneous tissue C50.8 C44.1 C30.1 Inner breast canthus ear C00.5 C00.4 C00.3 Inner aspect of lip NOS lower upper C41.4 C77.1 C71.0 Innominate bone Innominate lymph node Insula M-8337/3 Insular carcinoma (C73.9) M-8151/0 Insulinoma, NOS (C25._) M-8151/3 Insulinoma, malignant (C25._) 177 Alphabetic Index C77.1 C49.3 C47.3 Intercostal lymph node muscle nerve M-9757/3 Interdigitating cell sarcoma M-9757/3 Interdigitating dendritic cell sarcoma M------/-2 Intermediate differentiation (see grading code, page 34) M-8761/1 M-8044/3 M-9362/3 M-8631/1 M-8634/1 M-9083/3 Intermediate and giant congenital nevus (C44._) cell, small cell carcinoma M--------- Internal endometriosis (see SNOMED) M-8650/1 M-8650/0 M-8650/3 M-8966/0 Interstitial cell tumor NOS benign malignant renomedullary (C64.9) C41.2 C77.2 C26.0 Intervertebral disc Intestinal lymph node Intestinal tract, NOS M-8504/3 M-8504/2 M-8504/3 M-8504/3 M-8504/0 M-8504/3 M-8504/0 Intracystic carcinoma, NOS carcinoma, noninfiltrating carcinoma, papillary papillary adenocarcinoma papillary adenoma papillary carcinoma papilloma M-8500/2 M-8503/2 M-8503/2 M-8503/2 M-8503/3 malignant teratoma Internal capsule cheek lip, NOS mammary artery nose os urethral orifice Intracranial arachnoid meninges site M-8750/0 Intradermal nevus (C44._) Differentiation pineal parenchymal tumor (C75.3) Sertoli-Leydig cell tumor Sertoli-Leydig cell tumor, with heterologous elements C71.0 C06.0 C00.5 C49.3 C30.0 C53.0 C67.5 C70.0 C70.0 C71.9 M-8522/3 Intraductal Adenocarcinoma noninfiltrating, NOS noninfiltrating papillary (C50._) papillary, NOS (C50._) papillary, noninfiltrating (C50._) papillary, with invasion (C50._) and lobular carcinoma (C50._) M-8543/3 M-8507/2 M-8507/2 M-8500/2 M-8503/2 M-8230/2 Carcinoma NOS (C50._) and lobular carcinoma in situ (C50._) and Paget disease, breast (C50._) clinging (C50._) micropapillary (C50._) noninfiltrating, NOS noninfiltrating, papillary (C50._) solid type M-8503/2 M-8503/2 M-8503/3 Papillary adenocarcinoma NOS (C50._) noninfiltrating (C50._) with invasion (C50._) M-8503/2 papillary carcinoma, NOS (C50._) Intestinal M-9764/3 small, immunoproliferative disease (C17._) M-8144/3 type adenocarcinoma (C16._) M-8144/3 type carcinoma (C16._) M-8453/0 M-8453/3 M-8453/2 M-8453/1 Papillary-mucinous adenoma (C25._) carcinoma, invasive (C25._) carcinoma, non-invasive (C25._) tumor with moderate dysplasia (C25._) Intestine NOS large (excludes rectum, NOS C20.9 and rectosigmoid junction C19.9) small, NOS M-8503/0 M-8505/0 M-8505/0 papilloma papillomatosis, NOS papillomatosis, diffuse C26.0 C18.9 C17.9 C77.2 C76.2 M-8500/2 M-8522/2 M-8070/2 M-8096/0 M-8740/0 M-8081/2 Intra-abdominal lymph nodes Intra-abdominal site, NOS M-9011/0 Intracanalicular fibroadenoma (C50._) M-9195/3 Intracortical osteosarcoma (C40._, C41._) 178 Intraepidermal carcinoma, NOS epithelioma of Jadassohn (C44._) nevus (C44._) squamous cell carcinoma, Bowen type (C44._) Alphabetic Index M-------/2 Intraepithelial (see behavior code, page 31) M-8010/2 Intraepithelial carcinoma, NOS M-9160/0 Involuting nevus (C44._) [obs] C69.4 C76.3 C41.4 C71.0 C25.4 M-8500/2 Intraepithelial neoplasia 3, ductal (C50._) M-8077/2 M-8077/2 M-8148/2 M-8148/2 M-8077/2 M-8077/2 M-8077/2 Intraepithelial neoplasia, grade III anal (C21.1) cervical (C53._) glandular prostatic (C61.9) squamous vaginal (C52._) vulvar (C51._) Islet cell adenocarcinoma (C25._) adenoma (C25._) adenomatosis (C25._) and exocrine adenocarcinoma, mixed (C25._) M-8150/3 carcinoma (C25._) M-8150/1 tumor, NOS (C25._) M-8150/0 tumor, benign (C25._) M-8150/3 M-8150/0 M-8150/0 M-8154/3 M-8070/2 Intraepithelial squamous cell carcinoma C22.1 Intrahepatic bile duct C25.4 C54.0 M-9132/0 Intramuscular hemangioma M-8856/0 Intramuscular lipoma M-9571/0 Intraneural perineurioma C69.4 J M-8780/0 M-8096/0 M--------- Jadassohn blue nevus (C44._) intraepidermal epithelioma (C44._) nevus sebaceus (see SNOMED) Jaw Intrapelvic lymph node Intrathoracic lymph node Intrathoracic site, NOS C76.0 C41.1 C41.1 C41.0 C44.3 M-9064/2 Intratubular germ cell neoplasia (C62._) M-9064/2 Intratubular malignant germ cells (C62._) M-9133/3 Intravascular bronchial alveolar tumor (C34._) [obs] M-8890/1 Intravascular leiomyomatosis C32.0 Islets of Langerhans Isthmus uteri Intraocular Intraosseous M-9270/3 carcinoma, primary (C41.1) M-9187/3 osteosarcoma, low grade (C40._, C41._) M-9187/3 osteosarcoma, well differentiated (C40._, C41._) C77.5 C77.1 C76.1 Iris Ischiorectal fossa Ischium Island of Reil Islands of Langerhans C17.1 Jejunum M--------- Jessner, benign lymphocytic infiltrate (see SNOMED) Intrinsic larynx M-8503/3 Invasion, intraductal papillary adenocarcinoma with (C50._) Invasive fibroma hydatidiform mole (C58.9) intraductal papillary-mucinous carcinoma (C25._) M-9100/1 mole, NOS (C58.9) M-8821/1 M-9100/1 M-8453/3 Inverted follicular keratosis (see SNOMED) papilloma, squamous cell Schneiderian papilloma (C30.0, C31._) M-8121/1 transitional cell papilloma, NOS M-8121/0 transitional cell papilloma, benign transitional papilloma, NOS M-8121/1 M--------M-8053/0 M-8121/1 179 NOS bone, NOS bone, lower bone, upper skin C41.9 C40.0 C40.3 C41.3 C40.0 C40.3 C40.1 C41.4 C40.2 C40.2 C40.2 C40.9 C40.0 C41.3 C41.1 C40.1 Joint NOS acromioclavicular ankle costovertebral elbow foot hand hip knee, NOS knee, lateral meniscus knee, medial meniscus limb, NOS shoulder sternocostal temporomandibular wrist C77.0 Jugular lymph node Alphabetic Index M-8690/1 Jugular paraganglioma (C75.5) M-8690/1 Jugulare tumor, glomus, NOS (C75.5) M-8690/1 Jugulotympanic paraganglioma (C75.5) C21.8 C16.0 C16.0 C16.0 C05.8 C18.0 C19.9 C65.9 C19.9 C05.8 C53.8 M--------M--------M--------M--------M--------M--------M--------- Junction anorectal cardioesophageal esophagogastric gastroesophageal hard and soft palate ileocecal pelvirectal pelviureteric rectosigmoid soft and hard palate squamocolumnar of cervix M-9142/0 Keratotic hemangioma, verrucous M-8052/0 Keratotic papilloma C64.9 C64.9 C65.9 M-8740/0 Junction nevus (C44._) M-8740/0 Junctional nevus, NOS (C44._) M-8740/3 Junctional nevus, malignant melanoma in (C44._) C10.8 C02.8 M-9160/0 M--------M-9421/1 M-8502/3 M-9030/0 M-8622/1 M-9131/0 M-8831/0 M-8770/0 M-8770/0 M--------M--------- Keratosis NOS (see SNOMED) actinic (see SNOMED) benign squamous (see SNOMED) inverted follicular (see SNOMED) obturans (see SNOMED) seborrheic (see SNOMED) senile (see SNOMED) Kidney NOS parenchyma pelvis M-8162/3 Klatskin tumor (C22.1, C24.0) C76.5 C44.7 C49.2 C49.2 C47.2 C49.2 C49.2 C49.2 C40.2 C40.2 C40.2 C40.3 C47.2 C44.7 C49.2 C49.2 C49.2 C49.2 Junctional region of oropharynx Junctional zone of tongue Juvenile angiofibroma aponeurotic fibroma (see SNOMED) astrocytoma (C71._) In North America, report as 9421/3 carcinoma, breast (C50._) fibroadenoma (C50._) granulosa cell tumor (C56.9) hemangioma histiocytoma melanoma (C44._) nevus (C44._) polyp (see SNOMED) xanthogranuloma (see SNOMED) Knee NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue joint, NOS joint, lateral meniscus joint, medial meniscus patella peripheral nerve skin soft tissue subcutaneous tissue tendon tendon sheath M-8490/6 Krukenberg tumor (C56.9) M-9124/3 Kupffer cell sarcoma (C22.0) Juxtacortical M-9221/0 chondroma (C40._, C41._) M-9221/3 chondrosarcoma (C40._, C41._) M-9192/3 osteosarcoma (C40._, C41._) L M-8361/0 Juxtaglomerular tumor (C64.9) K M-9140/3 Kaposi sarcoma M-9130/1 Kaposiform hemangioendothelioma M--------- Keloid (see SNOMED) Keratinizing M-8071/3 epidermoid carcinoma M-8071/3 squamous cell carcinoma, NOS M-8071/3 squamous cell carcinoma, large cell M--------M--------- Keratoacanthoma, NOS (see SNOMED) Keratocyst (see SNOMED) 180 M-------- L_ (see Leukemia, FAB, L_) C51.9 C51.0 C51.0 C51.1 Labia NOS majora, NOS majora, skin minora C00.6 C06.1 Labial commissure Labial sulcus C51.9 C51.0 C51.1 Labium NOS majus minus Alphabetic Index C69.5 C69.5 C69.5 C69.5 Lacrimal duct, NOS duct, nasal gland sac M-8204/0 Lactating adenoma (C50._) C25.4 C25.4 Langerhans, islands Langerhans, islets M-9751/1 M-9752/1 Langerhans cell granulomatosis, NOS granulomatosis, unifocal M-9751/1 M-9754/3 M-9754/3 M-9752/1 M-9753/1 M-9753/1 M-9752/1 Histiocytosis NOS disseminated generalized mono-ostotic multifocal poly-ostotic unifocal M-9756/3 sarcoma C18.9 Large bowel, NOS M-8642/1 Large cell calcifying Sertoli cell tumor M-8012/3 M-8072/3 M-8013/3 M-8071/3 M-8072/3 M-8014/3 Large cell carcinoma NOS epidermoid, nonkeratinizing neuroendocrine squamous cell, keratinizing squamous cell, nonkeratinizing, NOS with rhabdoid phenotype Laryngeal aspect of aryepiglottic fold cartilage commissure C13.9 Laryngopharynx C32.9 C32.3 C32.3 C32.3 C32.1 C32.1 C04.1 C40.2 C71.5 C71.5 Lateral floor of mouth meniscus of knee joint ventricle, NOS ventricle, choroid plexus C67.2 C10.2 C11.2 C10.2 C14.0 Lateral wall bladder mesopharynx nasopharynx oropharynx pharynx, NOS C49.3 Latissimus dorsi muscle C18.6 Left colon Leg C76.5 C44.7 C49.2 C49.2 C47.2 C40.2 C49.2 C49.2 C49.2 C77.4 C49.2 C47.2 C49.2 C44.7 C49.2 C49.2 C49.2 C49.2 Large intestine (excludes rectum, NOS C20.9 and rectosigmoid junction C19.9) C32.1 C32.3 C32.0 Larynx, continued extrinsic false cord false vocal cord glottis intrinsic laryngeal aspect of aryepiglottic fold laryngeal cartilage laryngeal commissure subglottis supraglottis thyroid cartilage true cord true vocal cord ventricular band vocal cord, NOS M-8520/2 LCIS, NOS (C50._) M-9474/3 Large cell medulloblastoma (C71.6) M-8045/3 Large cell-small cell carcinoma, combined (C34._) M-9831/1 Large granular lymphocytic leukemia, NKcell M-9831/1 Large granular lymphocytosis, T-cell C18.9 C32.1 C32.1 C32.1 C32.0 C32.0 C32.1 C32.3 C32.0 C32.2 C32.1 C32.3 C32.0 C32.0 C32.1 C32.0 Larynx NOS arytenoid cartilage cricoid cartilage cuneiform cartilage epiglottis, NOS (excludes anterior surface of epiglottis C10.1) epiglottis, posterior surface NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue lymph node muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath M-8891/0 Leiomyoblastoma M-8890/0 Leiomyofibroma M-8890/0 M-8893/0 M-8893/0 181 Leiomyoma NOS atypical bizarre Alphabetic Index M-8892/0 M-8891/0 M-8898/1 M-8893/0 M-8890/0 M-8893/0 M-8894/0 Leiomyoma, continued cellular epithelioid metastasizing pleomorphic plexiform symplastic vascular M-9835/3 M-9835/3 M-9826/3 M-9835/3 M-8890/1 Leiomyomatosis, NOS M-8890/1 Leiomyomatosis, intravascular M-9835/3 M-9835/3 M-9837/3 Leiomyosarcoma M-8890/3 NOS M-8891/3 epithelioid M-8896/3 myxoid M-9910/3 M-9805/3 M-9891/3 M-9702/3 Lennert lymphoma C69.4 Lens, crystalline M-9891/3 M-9872/3 M-9861/3 M-8832/0 Lenticulare, dermatofibroma (C44._) M-8744/3 Lentiginous melanoma, acral, malignant (C44._) M-8746/3 Lentiginous melanoma, mucosal M--------M-8742/2 M-8742/3 M-9874/3 M-9861/3 Lentigo NOS (see SNOMED) maligna (C44._) maligna melanoma (C44._) M-9861/3 M-9897/3 M-9896/3 M-9871/3 M-9871/3 M-9840/3 M-9872/3 M-9897/3 M-9866/3 M-9896/3 M-9866/3 M-9871/3 M-9920/3 M-9920/3 M-9530/3 Leptomeningeal sarcoma (C70._) M-9766/1 Lesion, angiocentric immunoproliferative M-8762/1 Lesion, proliferative dermal, in congenital nevus (C44._) C16.5 Lesser curvature of stomach, NOS (not classifiable to C16.1 to C16.4) M-9754/3 Letterer-Siwe disease M--------- Leucokeratosis (see SNOMED) M--------- Leucoplakia, NOS (see SNOMED) M-9800/3 M-9897/3 M-9801/3 M-9826/3 M-9870/3 M-9805/3 M-9805/3 M-9826/3 M-9837/3 M-9840/3 M-9861/3 M-9835/3 M-9835/3 Leukemia (C42.1) NOS 11q23 abnormalities, acute myeloid M-9920/3 M-9871/3 Acute NOS B-ALL (see also M-9687/3) basophilic bilineal biphenotypic Burkitt type (see also M-9687/3) [obs] cortical T ALL (see also M-9729/3) erythroid granulocytic (FAB or WHO type not specified) L2 type lymphoblastic, NOS (see also M-9727/3) lymphatic (see also M-9727/3) M-9874/3 M-9895/3 M-9895/3 M-9873/3 M-9895/3 M-9867/3 M-9871/3 M-9861/3 M-9836/3 182 Leukemia, continued Acute, continued Lymphoblastic NOS (see also M-9727/3) L2 type, NOS (see also M-9727/3) mature B-cell type (see also M-9687/3) precursor-cell type (see also M-9727/3) lymphocytic (see also M-9727/3) lymphoid (see also M-9727/3) mature T ALL (see also M-9729/3) megakaryoblastic mixed lineage monoblastic (includes all variants) monocytic (includes all variants) myeloblastic myelocytic (FAB or WHO type not specified) myelocytic, with maturation myelogenous (FAB or WHO type not specified) Myeloid NOS (FAB or WHO type not specified) 11q23 abnormalities AML1(CBF-alpha)/ETO CBF-beta/MYH11 inv(16)(p13:q22) M6 type minimal differentiation MLL PML/RAR-alpha t(8;21)(q22;q22) t(15;17)(q22;q11-12) t(16;16)(p13;q11) therapy related, NOS therapy related, alkylating agent related therapy related, epipodophyllotoxin related with abnormal marrow eosinophils (includes all variants) with maturation with multilineage dysplasia with prior myelodysplastic syndrome without maturation without prior myelodysplastic syndrome myelomonocytic, NOS myelomonocytic, with abnormal eosinophils non-lymphocytic (FAB or WHO type not specified) pre-B ALL (see also M-9728/3) Alphabetic Index M-9836/3 M-9837/3 M-9836/3 M-9837/3 M-9866/3 M-9866/3 M-9866/3 M-9871/3 M-9895/3 M-9895/3 M-9873/3 M-9895/3 M-9827/3 M-9827/3 M-9827/3 Leukemia, continued Acute, continued pre-pre-B ALL (see also M-9728/3) Pre-T ALL (see also M-9729/3) pro-B ALL (see also M-9728/3) Pro-T ALL (see also M-9729/3) promyelocytic, NOS (includes variants) promyelocytic, PML/RAR-alpha promyelocytic, t(15;17)(q22;q1112) with abnormal marrow eosinophils, myeloid (includes all variants) with multilineage dysplasia, myeloid with prior myelodysplastic syndrome, myeloid without maturation, myeloid without prior myelodysplastic syndrome, myeloid aggressive NK-cell M-9800/3 M-9860/3 M-9820/3 M-9820/3 M-9820/3 M-9860/3 M-9860/3 M-9860/3 Aleukemic NOS [obs] granulocytic [obs] lymphatic [obs] lymphocytic [obs] lymphoid [obs] monocytic [obs] myelogenous [obs] myeloid [obs] M-9840/3 M-9896/3 M-9896/3 M-9876/3 M-9876/3 M-9826/3 M-9823/3 M-9836/3 M-9870/3 basophilic, acute M-9875/3 M-9876/3 BCR/ABL chronic granulocytic negative, atypical chronic myeloid positive, chronic myelogenous M-9875/3 M-9805/3 M-9805/3 M-9801/3 M-9826/3 M-9826/3 Adult T-cell (includes all variants) T-cell leukemia/lymphoma (HTLV-1 positive) (includes all variants) T-cell lymphoma/leukemia (includes all variants) M-9948/3 M-9920/3 Leukemia, continued B-cell, continued M-9823/3 type, chronic lymphocytic, (include all variants of BCLL) (see also M-9670/3) M-9826/3 type, mature, acute lymphoblastic, (see also M-9687/3) M-9833/3 type, prolymphocytic M-9836/3 M-9871/3 M-9800/3 M-9876/3 M-9876/3 M-9823/3 M-9964/3 M-9875/3 M-9946/3 M-9823/3 juvenile myelomonocytic lymphatic (see also M-9670/3) M-9823/3 M-9823/3 M-9823/3 B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (see also M-9670/3) lymphoblastic, precursor (see also M-9728/3) M-9823/3 M-9860/3 M-9863/3 M-9874/3 183 Chronic NOS [obs] atypical myeloid, BCR/ABL negative atypical myeloid, Philadelphia chromosome Ph1 negative B-cell, lymphocytic leukemia/small lymphocytic lymphoma (see also M-9670/3) eosinophilic Granulocytic NOS BCR/ABL Philadelphia chromosome Ph1 positive t(9;22)(q34;q11) M-9863/3 M-9875/3 M-9875/3 Alkylating agent related, therapy related, acute myeloid AML M6 AML1(CBF-alpha)/ETO, acute myeloid AML1(CBF-alpha)/ETO, FAB M2 atypical chronic myeloid, BCR/ABL negative atypical chronic myeloid, Philadelphia chromosome Ph1 negative B-ALL (see also M-9687/3) bilineal, acute biphenotypic, acute blast cell Burkitt cell (see also M-9687/3) Burkitt type, acute (see also M-9687/3) [obs] C-ALL (see also M-9728/3) CBF-beta/MYH11, acute myeloid Lymphocytic NOS (see also M-9670/3) B-cell type (include all variants of BCLL) (see also M-9670/3) leukemia/small lymphocytic lymphoma, B-cell (see also M-9670/3) lymphoid (see also M-9670/3) monocytic [obs] myelocytic, NOS myelocytic, with maturation Alphabetic Index M-9863/3 M-9875/3 M-9875/3 M-9875/3 M-9863/3 M-9876/3 M-9876/3 Leukemia, continued Chronic, continued Myelogenous NOS BCR/ABL Philadelphia chromosome Ph1 positive t(9;22)(q34;q11) Myelomonocytic NOS in transformation [obs] juvenile Type I Type II M-9963/3 neutrophilic M-9840/3 common ALL (see also M-9728/3) common precursor ALL (see also M-9728/3) cortical T ALL (see also M-9729/3) eosinophilic eosinophilic, chronic Epipodophyllotoxin related therapy related acute myeloid erythroid, acute M-9835/3 M-9835/3 M-9826/3 M-9872/3 M-9873/3 M-9874/3 M-9896/3 M-9896/3 M-9866/3 M-9867/3 M-9871/3 M-9891/3 M-9840/3 M-9910/3 FAB L1 [obs] (see also M-9727/3) L2 (see also M-9727/3) L3 (see also M-9687/3) M0 M1 M2, NOS M2, AML1(CBF-alpha)/ETO) M2, t(8;21)(q22;q22) M3 (includes all variants) M4 M4Eo M5 (includes all variants) M6 M7 M-9831/1 M-9831/1 granular lymphocytic, NK cell large granular lymphocytic, T-cell large M-9860/3 M-9861/3 Granulocytic NOS acute (FAB or WHO type not specified) aleukemic [obs] M-9837/3 M-9860/3 M-9964/3 M-9920/3 M-9860/3 M-9863/3 M-9875/3 M-9860/3 Myeloid NOS BCR/ABL negative, atypical Philadelphia chromosome Ph1 negative, atypical M-9945/3 M-9945/3 M-9946/3 M-9945/3 M-9945/3 M-9836/3 M-9836/3 Leukemia, continued Granulocyticd, continued Chronic, continued M-9875/3 Philadelphia chromosome (Ph1) positive M-9875/3 t(9;22)(q34;q11) M-9940/3 M-9940/3 M-9871/3 M-9946/3 M-9946/3 M-9831/1 M-9831/1 M-9835/3 hairy cell hairy cell, variant inv(16)(p13:q22), acute myeloid juvenile myelomonocytic juvenile myelomonocytic, chronic large granular lymphocytic, NK cell large granular lymphocytic, T-cell L2 type acute lymphoblastic, NOS M-9820/3 M-9835/3 M-9820/3 M-9823/3 M-9820/3 Lymphatic NOS [obs] acute (see also M-9727/3) aleukemic [obs] chronic (see also M-9670/3) subacute [obs] M-9835/3 Lymphoblastic NOS (see also M-9727/3) M-9835/3 M-9835/3 M-9826/3 M-9835/3 M-9836/3 M-9835/3 M-9837/3 M-9820/3 M-9835/3 M-9820/3 M-9826/3 M-9823/3 M-9823/3 M-9823/3 M-9831/1 M-9836/3 M-9836/3 M-9836/3 M-9820/3 M-9831/1 Chronic NOS BCR/ABL 184 subacute [obs] Acute NOS (see also M-9727/3) L2 type, NOS mature B-cell type (see also M-9727/3) precursor-cell type (see also M-9727/3) Precursor B-cell (see also M-9728/3) cell, not phenotyped (see also M-9727/3) T-cell (see also M-9729/3) Lymphocytic NOS [obs] acute (see also M-9727/3) aleukemic [obs] B-ALL (see also M-9687/3) B-cell chronic, leukemia/small lymphocytic lymphoma (see also M-9670/3) chronic (see also M-9670/3) chronic, B-cell type (includes all variants of BCLL) (see also M-9670/3) NK cell large granular pre-B ALL (see also M-9728/3) pre-pre-B ALL (see also M-9728/3) pro-B ALL (see also M-9728/3) subacute [obs] T-cell large granular Alphabetic Index M-9820/3 M-9835/3 M-9820/3 M-9823/3 M-9820/3 M-9820/3 M-9840/3 M-9840/3 M-9840/3 M-9742/3 M-9826/3 M-9910/3 M-9910/3 M-9872/3 M-9805/3 M-9897/3 M-9891/3 M-9891/3 M-9895/3 Leukemia, continued Lymphoid NOS acute (see also M-9727/3) aleukemic [obs] chronic (see also M-9670/3) subacute [obs] M-9896/3 M-9871/3 M-9871/3 M-9840/3 M-9872/3 M-9897/3 M-9866/3 M-9896/3 M-9866/3 M-9871/3 M-9920/3 M-9920/3 lymphosarcoma cell [obs] M6 type acute myeloid M6A M6B mast cell (C42.1) mature B-cell type, lymphoblastic, acute (see also M-9687/3) megakaryoblastic, acute megakaryocytic minimal differentiation, acute myeloid mixed lineage, acute MLL, acute myeloid monoblastic, NOS (includes all variants) monoblastic, acute multilineage dysplasia, acute myeloid with M-9920/3 M-9871/3 M-9874/3 M-9895/3 M-9895/3 M-9873/3 M-9895/3 M-9860/3 M-9891/3 M-9860/3 M-9860/3 M-9860/3 Monocytic NOS acute (includes all variants) aleukemic [obs] chronic [obs] subacute [obs] M-9872/3 Myeloblastic, acute M-9876/3 Myelocytic NOS acute (FAB or WHO type not specified) acute, with maturation chronic, NOS M-9863/3 M-9876/3 Myelogenous NOS acute (FAB or WHO type not specified) aleukemic [obs] M-9871/3 M-9860/3 M-9871/3 M-9860/3 M-9861/3 M-9874/3 M-9863/3 M-9860/3 M-9861/3 M-9860/3 M-9875/3 Chronic NOS BCR/ABL Philadelphia chromosome Ph1 positive t(9;22)(q34;q11) M-9860/3 subacute [obs] M-9863/3 M-9875/3 M-9875/3 M-9860/3 M-9897/3 M-9861/3 M-9860/3 M-9876/3 M-9876/3 M-9874/3 M-9895/3 M-9895/3 M-9873/3 M-9895/3 Myeloid NOS 11q23 abnormalities, acute acute, NOS (FAB or WHO type not specified) (see also M-9930/3) M-9860/3 M-9867/3 M-9871/3 M-9945/3 M-9945/3 M-9946/3 185 Leukemia, continued Myeloid, continued Acute AML1(CBF-alpha)/ETO CBF-beta/MYH11 inv(16)(p13:q22) M6 type minimal differentiation MLL PML/RAR-alpha t(8;21)(q22;q22) t(15;17)(q22;q11-12) t(16;16)(p13;q11) therapy related, NOS therapy related, alkylating agent related therapy related, epipodophyllotoxin related with abnormal marrow eosinophils (includes all variants) with maturation with multilineage dysplasia with prior myelodysplastic syndrome without maturation without prior myelodysplastic syndrome aleukemic [obs] atypical chronic, BCR/ABL negative atypical chronic, Philadelphia chromosome Ph1 negative Chronic NOS BCR/ABL negative, atypical Philadelphia chromosome Ph1 negative, atypical inv(16)(p13:q22), acute subacute [obs] with abnormal marrow eosinophils, acute (includes all variants) with maturation, acute with multilineage dysplasia, acute with prior myelodysplastic syndrome, acute without maturation, acute without prior myelodysplastic syndrome, acute Myelomonocytic NOS acute acute, with abnormal eosinophils chronic, NOS chronic, in transformation chronic, juvenile Alphabetic Index M-9945/3 M-9945/3 M-9945/3 M-9946/3 M-9946/3 M-9871/3 M-9948/3 M-9831/1 M-9963/3 M-9860/3 M-9861/3 Leukemia, continued Myelomonocytic, continued chronic, Type I chronic, Type II in transformation, chronic juvenile juvenile, chronic with abnormal eosinophils, acute (includes all variants) M-9875/3 M-9875/3 M-9733/3 M-9733/3 M-9836/3 M-9836/3 M-9837/3 plasma cell (C42.1) plasmacytic (C42.1) pre-B ALL (see also M-9728/3) pre-pre-B ALL (see also M-9728/3) pre-T ALL (see also M-9729/3) M-9836/3 M-9835/3 M-9835/3 M-9837/3 M-9836/3 M-9837/3 M-9832/3 M-9833/3 M-9834/3 Prolymphocytic NOS B-cell type T-cell type M-9866/3 M-9866/3 M-9866/3 Promyelocytic acute, NOS (includes variants) acute, PML/RAR-alpha acute, t(15;17)(q22;q11-12) M-9801/3 stem cell M-9800/3 M-9860/3 M-9820/3 M-9820/3 Subacute NOS [obs] granulocytic [obs] lymphatic [obs] lymphocytic [obs] M-9895/3 M-9837/3 M-9827/3 M-9834/3 T-cell adult (includes all variants) large granular lymphocytic leukemia/lymphoma (HTLV-1 positive), adult (includes all variants) lymphoblastic, precursor (see also M-9729/3) lymphoma/leukemia, adult (includes all variants) type, prolymphocytic M-9871/3 t(8;21)(q22;q22), acute myeloid t(8;21)(q22;q22), FAB M2 t(9;22)(q34;q11), chronic granulocytic t(9;22)(q34;q11), chronic myelogenous t(15;17)(q22;q11-12), acute myeloid t(15;17)(q22;q11-12), acute promyelocytic t(16;16)(p13;q11), acute myeloid M-9920/3 M-9920/3 M-9920/3 Therapy related acute myeloid NOS alkylating agent related epipodophyllotoxin related M-9896/3 M-9896/3 M-9875/3 M-9875/3 M-9866/3 M-9866/3 Precursor B-cell lymphoblastic (see also M-9728/3) cell, acute lymphoblastic, not phenotyped (see also M-9727/3) cell type, acute lymphoblastic (see also M-9727/3) T-cell lymphoblastic (see also M-9729/3) prior myelodysplastic syndrome, acute myeloid with prior myelodysplastic syndrome, acute myeloid without pro-B ALL (see also M-9728/3) pro-T ALL (see also M-9729/3) M-9895/3 M-9827/3 M-9831/1 M-9827/3 NK-cell, aggressive NK-cell large granular lymphocytic neutrophilic, chronic non-lymphocytic, NOS non-lymphocytic, acute (FAB or WHO type not specified) Philadelphia chromosome Ph1 negative, atypical chronic myeloid positive, chronic granulocytic positive, chronic myelogenous M-9876/3 M-9820/3 M-9860/3 M-9860/3 M-9860/3 Leukemia, continued Subacute, continued lymphoid [obs] monocytic [obs] myelogenous [obs] myeloid [obs] M-9801/3 M-9871/3 M-9871/3 M-9874/3 M-9895/3 M-9895/3 M-9873/3 M-9895/3 undifferentiated with abnormal marrow eosinophils, acute myeloid (includes all variants) with abnormal marrow eosinophils, acute myelomonocytic (includes all variants) with maturation, acute myeloid with multilineage dysplasia, acute myeloid with prior myelodysplastic syndrome, acute myeloid without maturation, acute myeloid without prior myelodysplastic syndrome, acute myeloid Leukemia-lymphoma acute lymphoblastic, NOS (see also M-9727/3) M-9827/3 adult T-cell (includes all variants) M-9827/3 adult T-cell (HTLV-1 positive) (includes all variants) M-9823/3 B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (see also M-9670/3) M-9835/3 M-9940/3 Leukemic reticuloendotheliosis 186 Alphabetic Index M-8650/1 M-8650/0 M-8650/3 M-8631/1 M-8631/1 M-8634/1 M-8631/3 M-8634/3 M-8633/1 M-8634/1 M-8631/3 M-8631/0 Leydig cell tumor NOS (C62._) benign (C62._) malignant (C62._) C00.4 C44.0 C00.1 C00.5 C00.4 C00.3 C44.0 C00.0 Leydig-Sertoli cell tumor NOS intermediate differentiation intermediate differentiation, with heterologous elements poorly differentiated poorly differentiated, with heterologous elements retiform retiform, with heterologous elements sarcomatoid well differentiated C00.0 C00.3 C00.3 C00.3 C44.0 C00.0 C00.2 C00.1 C00.0 M-9493/0 Lhermitte-Duclos dysplastic gangliocytoma of cerebellum (C71.6) Lid C44.1 C44.1 C44.1 NOS lower upper C49.9 C57.1 C57.2 C57.3 C57.3 Ligament NOS broad round uterine uterosacral Lipid cell tumor of ovary (C56.9) storage, Sertoli cell tumor with (C56.9) M-8641/0 storage, tubular androblastoma with (C56.9) M-8670/0 M-8641/0 M-9769/1 Light chain disease, systemic C69.1 C02.9 C02.4 C34.1 Limbus of cornea Lingual, NOS Lingual tonsil Lingula, lung M-8142/3 Linitis plastica (C16._) Lip C00.9 C00.6 C00.6 C00.2 C00.1 C00.0 C00.5 C00.5 C00.4 C00.3 C00.5 C00.4 C00.3 C00.5 C00.6 C00.1 C00.1 C00.4 C00.4 Lip, continued lower, mucosa lower, skin lower, vermilion border mucosa, NOS mucosa, lower mucosa, upper skin, NOS upper, NOS (excludes skin of upper lip C44.0) upper, external upper, frenulum upper, inner aspect upper, mucosa upper, skin upper, vermilion border vermilion border, NOS vermilion border, lower vermilion border, upper NOS (excludes skin of lip C44.0) commissure commissure, labial external, NOS external, lower external, upper frenulum, NOS frenulum labii, NOS frenulum, lower frenulum, upper inner aspect, NOS inner aspect, lower inner aspect, upper internal, NOS labial commissure lower, NOS (excludes skin of lower lip C44.0) lower, external lower, frenulum lower, inner aspect M-8314/3 M-8641/0 M-8641/0 M-8324/0 M-8881/0 M-8881/0 M--------M-8670/0 M-8890/0 Lipid-rich carcinoma (C50._) Lipid-rich Sertoli cell tumor Lipidique, folliculome Lipoadenoma Lipoblastoma Lipoblastomatosis Lipogranuloma, NOS (see SNOMED) Lipoid cell tumor, ovary (C56.9) Lipoleiomyoma M-8850/0 M-8850/1 M-8862/0 M-8881/0 M-8880/0 M-8856/0 M-8856/0 M-8854/0 M-8857/0 Lipoma NOS atypical chondroid fetal, NOS fetal fat cell infiltrating intramuscular pleomorphic spindle cell M-8851/3 Lipoma-like liposarcoma M--------M--------M-8881/0 Lipomatosis NOS (see SNOMED) diffuse (see SNOMED) fetal M-9506/1 Lipomatous medulloblastoma (C71.6) M-9506/1 Liponeurocytoma, cerebellar M-8850/3 M-8858/3 M-8851/3 M-8857/3 187 Liposarcoma NOS dedifferentiated differentiated fibroblastic Alphabetic Index M-8851/3 M-8851/3 M-8855/3 M-8852/3 M-8854/3 M-8853/3 M-8851/3 M-8850/1 M-8851/3 M-8850/1 Liposarcoma, continued inflammatory lipoma-like mixed myxoid pleomorphic round cell sclerosing superficial well differentated well differentiated well differentiated, superficial soft tissue C22.0 Liver M-------/1 Low malignant potential (see grading code, page 31) Low malignant potential endometrioid tumor mucinous tumor, NOS (C56.9) papillary mucinous tumor (C56.9) papillary serous tumor (C56.9) papillary transitional cell neoplasm (C67._) M-8130/1 papillary urothelial neoplasm (C67._) M-8442/1 serous tumor, NOS (C56.9) M-8380/1 M-8472/1 M-8473/1 M-8462/1 M-8130/1 M-8170/0 Liver cell adenoma (C22.0) M-8170/3 Liver cell carcinoma (C22.0) C71.1 C34.3 C34.3 C34.2 C34.2 C71.4 C71.3 C71.2 C34.1 C34.1 Lobe frontal lower, bronchus lower, lung middle, bronchus middle, lung occipital parietal temporal upper, bronchus upper, lung Lobular adenocarcinoma (C50._) and ductal carcinoma (C50._) and infiltrating duct carcinoma (C50._) M-8522/3 and intraductal carcinoma (C50._) M-8520/3 M-8522/3 M-8522/3 M-8520/3 M-8520/2 M-8522/3 M-8522/2 M-8520/3 M-8522/3 M-8520/2 M--------M-8524/3 C44.2 Carcinoma NOS (C50._) in situ (C50._) in situ and infiltrating duct (C50._) in situ and intraductal carcinoma (C50._) infiltrating (C50._) infiltrating, and ductal carcinoma in situ (C50._) noninfiltrating (C50._) hyperplasia (see SNOMED) infiltrating, mixed with other types of carcinoma (C50._) Lobule, ear M-8815/0 Localized fibrous tumor M-8525/3 M-9400/3 M-9400/3 M-8931/3 M-9187/3 C00.1 C00.4 C00.4 C00.4 C44.0 C00.1 C34.3 C34.3 C50.5 C15.5 C54.0 Lower alveolar mucosa alveolar ridge mucosa alveolus breast gingiva gum inner quadrant of breast jaw bone lid lip, NOS (excludes skin of lower lip C44.0) lip, external lip, frenulum lip, inner aspect lip, mucosa lip, skin lip, vermilion border lobe, bronchus lobe, lung outer quadrant of breast third of esophagus uterine segment C76.5 C44.7 C49.2 C49.2 C47.2 C49.2 C49.2 C49.2 C40.2 C40.2 C77.4 C49.2 C47.2 C40.3 C40.3 C49.2 C44.7 C49.2 C49.2 C49.2 C49.2 Lower limb NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue long bones long bones, joints lymph node muscle peripheral nerve short bones short bones, joints skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath C72.0 C77.2 Lumbar cord lymph node C03.1 C03.1 C03.1 C50.8 C03.1 C03.1 C50.3 C41.1 C44.1 C00.1 Low grade adenocarcinoma, polymorphous astrocytoma (C71._) diffuse astrocytoma (C71._) endometrial stromal sarcoma (C54.1) osteosarcoma, intraosseous 188 Alphabetic Index C47.6 Lumbar, continued nerve C47.5 Lumbosacral plexus C34.9 C34.9 C34.9 C34.9 C34.3 C34.0 C34.2 C34.1 C34.0 C34.0 C34.1 C34.3 C34.3 C34.0 C34.2 C34.2 C34.9 C34.1 C34.1 Lung NOS bronchiole bronchogenic bronchus, NOS bronchus, lower lobe bronchus, main bronchus, middle lobe bronchus, upper lobe carina hilus lingula lower lobe lower lobe, bronchus main bronchus middle lobe middle lobe, bronchus pulmonary, NOS upper lobe upper lobe, bronchus M-8601/0 M-8610/0 M-8610/0 M--------- Luteinized thecoma (C56.9) Luteinoma (C56.9) Luteoma, NOS (C56.9) Luteoma, pregnancy (see SNOMED) C------- Lymph gland (see lymph node) C77.9 C77.2 C77.2 C77.3 C77.0 C77.3 C77.3 C77.3 C77.1 C77.1 C77.2 C77.0 C77.4 C77.2 C77.2 C77.3 C77.1 C77.5 C77.3 C77.1 C77.0 C77.0 C77.4 C77.2 C77.4 C77.0 C77.2 C77.1 C77.1 Lymph node NOS abdominal aortic arm auricular axilla axillary brachial bronchial bronchopulmonary celiac cervical Cloquet colic common duct cubital diaphragmatic epigastric, inferior epitrochlear esophageal face facial femoral gastric groin head hepatic hilar, NOS hilar, pulmonary C77.2 C77.5 C77.2 C77.5 C77.5 C77.2 C77.3 C77.4 C77.4 C77.1 C77.1 C77.2 C77.2 C77.5 C77.1 C77.0 C77.4 C77.4 C77.2 C77.0 C77.1 C77.2 C77.2 C77.2 C77.2 C77.8 C77.0 C77.5 C77.0 C77.2 C77.2 C77.5 C77.5 C77.1 C77.0 C77.3 C77.5 C77.2 C77.2 C77.4 C77.2 C77.2 C77.0 C77.0 C77.5 C77.0 C77.1 C77.1 C77.2 C77.2 C77.0 C77.4 C77.5 C77.0 C77.2 C77.2 C77.3 C77.4 C77.0 C77.0 C77.0 C77.0 189 Lymph node, continued hilar, splenic hypogastric ileocolic iliac inferior epigastric inferior mesenteric infraclavicular inguinal inguinal region innominate intercostal intestinal intra-abdominal intrapelvic intrathoracic jugular leg lower limb lumbar mandibular mediastinal mesenteric, NOS mesenteric, inferior mesenteric, superior midcolic multiple regions neck obturator occipital pancreatic para-aortic paracervical parametrial parasternal parotid pectoral pelvic periaortic peripancreatic popliteal porta hepatis portal preauricular prelaryngeal presymphysial pretracheal pulmonary, NOS pulmonary hilar pyloric retroperitoneal retropharyngeal Rosenmuller sacral scalene splenic, NOS splenic hilar subclavicular subinguinal sublingual submandibular submaxillary submental Alphabetic Index C77.3 C77.2 C77.0 C77.1 C77.4 C77.1 C77.1 C77.3 Lymph node, continued subscapular superior mesenteric supraclavicular thoracic tibial tracheal tracheobronchial upper limb C77.8 Lymph nodes of multiple regions Lymphoid, continued hamartoma, angiomatous (see SNOMED) M--------hyperplasia, NOS (see SNOMED) M--------polyp, NOS (see SNOMED) M--------polyp, benign (see SNOMED) M-8512/3 stroma, medullary carcinoma with M--------- M-9590/3 Lymphoma, NOS {see Lymphoma (malignant)} Lymphoma (malignant) NOS adult T-cell (includes all variants) adult T-cell leukemia/lymphoma (HTLV-1 positive) (includes all variants) M-9827/3 adult T-cell lymphoma/leukemia (includes all variants) M-9705/3 AILD (Angioimmunoblastic Lymphadenopathy with Dysproteinemia), peripheral T-cell [obs] M-9680/3 anaplastic large B-cell M-9767/1 Lymphadenopathy, angioimmunoblastic (AIL) M-9705/3 Lymphadenopathy, angioimmunoblastic, with dysproteinemia (AILD), peripheral T-cell lymphoma, [obs] M-9767/1 Lymphadenopathy, immunoblastic (IBL)[obs] M-9170/3 Lymphangioendothelial sarcoma M-9170/0 Lymphangioendothelioma, NOS M-9170/3 Lymphangioendothelioma, malignant M-9174/1 Lymphangioleiomyomatosis M-9590/3 M-9827/3 M-9827/3 Lymphangioma NOS capillary cavernous cystic M-9714/3 M-9714/3 M-9718/3 M-9714/3 Anaplastic large cell NOS CD 30+ primary cutaneous (C44._) T cell and Null cell type M-9719/3 M-9705/3 M-9705/3 M-9680/3 M-9670/3 angiocentric T-cell [obs] angioimmunoblastic [obs] angioimmunoblastic T-cell angiotropic B lymphocytic, small, NOS M-9835/3 Lymphoblastic leukemia-lymphoma, acute, NOS (see also M-9727/3) M-9727/3 Lymphoblastoma [obs] M-8583/1 Lymphocyte-rich thymoma, NOS (C37.9) M-8583/3 Lymphocyte-rich thymoma, malignant (C37.9) M-9591/3 M-9680/3 M-9680/3 M-9680/3 M-9680/3 M-9680/3 B-cell NOS anaplastic large diffuse large, NOS histiocyte-rich large intravascular intravascular large (C49.9) Lymphocytic infiltrate of Jessner, benign (see SNOMED) M-8583/1 thymoma, NOS (C37.9) M-8583/3 thymoma, malignant (C37.9) M-9680/3 M-9680/3 M-9680/3 M-9684/3 M-9170/0 M-9171/0 M-9172/0 M-9173/0 Lymphangiomatosis, systemic (see SNOMED) M-9174/0 Lymphangiomyoma M-9174/1 Lymphangiomyomatosis M-9170/3 Lymphangiosarcoma M--------- C49.9 Lymphatic, NOS M--------- M-8082/3 M-8082/3 Lymphocytoma cutis, benign (see SNOMED) Lymphocytosis, T-cell large granular Lymphoepithelial carcinoma Lymphoepithelial lesion, benign (see SNOMED) Lymphoepithelioma Lymphoepithelioma-like carcinoma M-9766/1 Lymphoid granulomatosis M--------M-9831/1 M-8082/3 M--------- M-9728/3 M-9699/3 M-9679/3 M-9699/3 M-9728/3 M-9670/3 M-9689/3 M-9680/3 190 Large NOS diffuse, NOS diffuse, centroblastic, NOS diffuse, immunoblastic,NOS lymphoblastic, precursor (see also M-9836/3) marginal zone, NOS mediastinal large (C38.3) monocytoid precursor, lymphoblastic (see also M-9836/3) small lymphocytic/chronic lymphocytic leukemia (see also M-9823/3) splenic marginal zone (C42.2) T-cell rich/histiocyte-rich large Alphabetic Index Lymphoma (malignant), B-cell, continued M-9680/3 T-cell rich large M-9679/3 thymic large (C37.9) M-9699/3 M-9699/3 M-9687/3 M-9687/3 M-9687/3 M-9687/3 M-9714/3 M-9718/3 M-9680/3 M-9680/3 M-9698/3 M-9680/3 M-9675/3 M-9675/3 M-9690/3 M-9673/3 M-9680/3 M-9591/3 M-9695/3 M-9680/3 M-9680/3 M-9698/3 M-9591/3 M-9591/3 M-9695/3 M-9680/3 M-9691/3 Lymphoma (malignant), Diffuse, continued M-9680/3 centroblastic M-9675/3 centroblastic-centrocytic [obs] M-9680/3 histiocytic BALT Bronchial associated lymphoid tissue Burkitt NOS (includes all variants) type, small noncleaved [obs] (includes all variants) type, undifferentiated [obs] (includes all variants) M-9680/3 M-9680/3 M-9684/3 Large B-cell NOS centroblastic, NOS immunoblastic, NOS M-9680/3 M-9680/3 M-9680/3 Large cell NOS [obs] cleaved noncleaved Burkitt-like CD30+ anaplastic large cell CD30+ large T-cell, primary cutaneous (C44._) M-9670/3 M-9673/3 Centroblastic NOS diffuse follicular large B-cell, diffuse, NOS M-9591/3 M-9670/3 M-9670/3 Centroblastic-centrocytic NOS [obs] diffuse [obs] follicular [obs] (see also M-9675/3) Cleaved cell NOS [obs] follicular small large, NOS [obs] large, diffuse large, follicular [obs] small, NOS [obs] small, diffuse [obs] small, follicular [obs] large cell, NOS [obs] mixed small, and large cell, follicular [obs] M-9596/3 M-9727/3 composite Hodgkin and non-Hodgkin convoluted cell [obs] M-9709/3 M-9718/3 M-9718/3 M-9709/3 Cutaneous NOS (C44._) [obs] CD30+ large T-cell, primary primary, anaplastic large-cell (C44._) T-cell, NOS (C44._) M-9591/3 Diffuse NOS M-9675/3 Mixed cell type [obs] lymphocytic-histiocytic [obs] small and large cell [obs] M-9680/3 noncleaved, NOS [obs] M-9670/3 M-9591/3 M-9591/3 M-9670/3 Small cell (see also M-9823/3) cell, noncleaved [obs] cleaved cell [obs] lymphocytic (see also M-9823/3) noncleaved, Burkitt type M-9675/3 M-9675/3 centrocytic [obs] (includes all variants: blastic, pleomorphic, small cell) cleaved and noncleaved, large cell [obs] M-9687/3 M-9717/3 M-9717/3 M-9690/3 M-9690/3 M-9690/3 M-9698/3 M-9690/3 M-9690/3 M-9695/3 M-9691/3 M-9698/3 M-9698/3 M-9698/3 M-9698/3 M-9691/3 191 Lymphocytic NOS (see also M-9823/3) intermediate differentiation [obs] (includes all variants: blastic, pleomorphic, small cell) poorly differentiated [obs] small (see also M-9823/3) well differentiated (see also M-9823/3) enteropathy associated T-cell lymphoma enteropathy type intestinal T-cell lymphoma Follicle center NOS (see also M-9675/3) follicular (see also M-9675/3) Follicular NOS (see also M-9675/3) centroblastic centroblastic-centrocytic [obs] (see also M-9675/3) follicle center (see also M-9675/3) grade 1 grade 2 grade 3 large cell, NOS large cell, noncleaved [obs] large cleaved cell [obs] mixed cell type [obs] Alphabetic Index Lymphoma (malignant), Follicular, continued M-9691/3 mixed small cleaved and large cell [obs] M-9698/3 noncleaved cell, NOS [obs] M-9695/3 small cleaved cell [obs] M-9716/3 M-9680/3 M-9680/3 hepatosplenic γδ (gamma-delta) cell histiocyte-rich large B-cell histiocyte-rich/T-cell rich large B-cell M-9680/3 M-9680/3 M-9698/3 M-9755/3 Histiocytic NOS [obs] diffuse nodular [obs] true M-9650/3 M-9596/3 Hodgkin (see Hodgkin lymphoma) Hodgkin and non-Hodgkin, composite M-9684/3 M-9684/3 M-9684/3 Immunoblastic NOS large B-cell, diffuse, NOS large cell M-9673/3 M-9591/3 intestinal T-cell intestinal T-cell, enteropathy type intravascular B-cell intravascular large B-cell (C49.9) Ki-1+ large cell [obs] M-9680/3 Large NOS M-9680/3 M-9680/3 M-9679/3 M-9680/3 M-9680/3 M-9679/3 M-9714/3 M-9680/3 M-9680/3 M-9698/3 M-9680/3 M-9714/3 M-9675/3 M-9691/3 M-9702/3 M-9718/3 M-9714/3 M-9718/3 M-9680/3 M-9680/3 M-9702/3 M-9727/3 M-9728/3 B-cell NOS anaplastic diffuse, NOS diffuse, centroblastic, NOS diffuse, immunoblastic, NOS histiocyte-rich large intravascular (C49.9) mediastinal (C38.3) T-cell rich T-cell rich/histiocyte-rich thymic (C37.9) Cell M-9714/3 M-9680/3 M-9714/3 M-9714/3 M-9680/3 M-9680/3 M-9698/3 M-9684/3 M-9680/3 M-9680/3 M-9698/3 M-9702/3 M-9718/3 intermediate differentiation, lymphocytic, diffuse [obs] (includes all variants: blastic, pleomorphic, small cell) intermediate differentiation, lymphocytic, nodular [obs] M-9717/3 M-9717/3 M-9680/3 M-9680/3 M-9714/3 M-9680/3 M-9680/3 M-9680/3 M-9680/3 M-9684/3 M-9680/3 M-9727/3 M-9729/3 M-9670/3 M-9670/3 M-9670/3 M-9673/3 anaplastic, NOS anaplastic, B-cell anaplastic, CD30+ anaplastic, T-cell and Null cell type CD30+ anaplastic cleaved, NOS [obs] M-9591/3 M-9670/3 192 Lymphoma, continued Large, continued Cell, continued cleaved and noncleaved [obs] cleaved, diffuse diffuse, NOS [obs] follicular, NOS immunoblastic noncleaved, NOS noncleaved, diffuse noncleaved, follicular [obs] peripheral T-cell primary cutaneous anaplastic (C44._) cleaved cell, NOS [obs] cleaved cell, follicular [obs] histiocyte-rich large B-cell large cell (Ki-1+) [obs] mixed small and large cell, diffuse [obs] mixed small cleaved and large cell, follicular [obs] peripheral T-cell, pleomorphic medium and large cell primary cutaneous anaplastic large-cell (C44._) T-cell and Null cell type, anaplastic primary cutaneous CD30+ rich/histiocyte-rich large Bcell rich large B-cell Lennert Lymphoblastic NOS (see also M-9835/3) precursor B-cell (see also M-9836/3) precursor cell, NOS (see also M-9835/3) precursor T-cell (see also M-9837/3) Lymphocytic NOS (see also M-9823/3) B, small, NOS (see also M-9823/3) diffuse, NOS (see also M-9823/3) diffuse, intermediate differentiation [obs] (includes all variants: blastic, pleomorphic, small cell) diffuse, poorly differentiated [obs] diffuse, small (see also M-9823/3) Alphabetic Index M-9670/3 M-9673/3 M-9690/3 M-9591/3 M-9695/3 M-9698/3 M-9591/3 M-9695/3 M-9670/3 M-9670/3 M-9670/3 M-9670/3 M-9670/3 M-9698/3 Lymphoma, continued Lymphocytic, continued diffuse, well differentiated (see also M-9823/3) intermediate differentiation, diffuse [obs] (includes all variants: blastic, pleomorphic, small cell) M-9671/3 M-9671/3 lymphoplasmacytic lymphoplasmacytoid M-9699/3 M-9673/3 MALT mantle cell (includes all variants: blastic, pleomorphic, small cell) mantle zone [obs] (includes all variants: blastic, pleomorphic, small cell) M-9690/3 M-9698/3 Nodular NOS [obs] (see also M-9675/3) histiocytic [obs] M-9591/3 M-9695/3 M-9698/3 Lymphocytic NOS [obs] (see also M-9675/3) intermediate differentiation [obs] poorly differentiated [obs] well differentiated [obs] M-9691/3 M-9691/3 mixed cell type [obs] mixed lymphocytic-histiocytic [obs] M-9591/3 non-Burkitt undifferentiated cell [obs] M-9680/3 M-9680/3 M-9591/3 M-9698/3 M-9680/3 Non-cleaved NOS and cleaved large cell [obs] cell, NOS cell, follicular, NOS [obs] diffuse, NOS [obs] M-9680/3 M-9680/3 M-9698/3 M-9687/3 M-9591/3 M-9591/3 M-9596/3 M-9714/3 193 Mixed cell type, diffuse [obs] cell type, follicular [obs] cell type, nodular [obs] lymphocytic-histiocytic, diffuse [obs] lymphocytic-histiocytic, nodular [obs] small and large cell, diffuse [obs] small cleaved and large cell, follicular [obs] M-9699/3 M-9690/3 Marginal zone NOS B-cell, NOS B-cell, splenic (C42.2) nodal splenic, NOS (C42.2) splenic, B-cell (C42.2) Lymphoma, continued mature T-cell, NOS mediastinal large B-cell (C38.3) Mediterranean medium and large cell, peripheral T-cell lymphoma, pleomorphic monocytoid B-cell mucosal-associated lymphoid tissue NK/T-cell lymphoma, nasal and nasaltype nodal marginal zone M-9699/3 M-9699/3 M-9719/3 well differentiated, diffuse (see also M-9823/3) well differentiated, nodular [obs] Lymphoid tissue bronchial-associated mucosa-associated skin-associated M-9699/3 M-9699/3 M-9689/3 M-9699/3 M-9689/3 M-9689/3 M-9675/3 M-9691/3 Small NOS (see also M-9823/3) B, NOS (see also M-9823/3) /B-cell chronic lymphocytic leukemia (see also M-9823/3) diffuse (see also M-9823/3) M-9699/3 M-9699/3 M-9699/3 M-9673/3 M-9691/3 poorly differentiated, diffuse [obs] poorly differentiated, nodular [obs] M-9702/3 M-9691/3 M-9675/3 M-9691/3 M-9691/3 M-9675/3 Nodular NOS [obs] (see also M-9675/3) intermediate differentiation [obs] poorly differentiated [obs] well differentiated [obs] lymphocytic-histiocytic, mixed, diffuse [obs] lymphocytic-histiocytic, mixed, nodular [obs] lymphoepithelioid M-9675/3 M-9702/3 M-9679/3 M-9764/3 M-9702/3 Large cell NOS diffuse follicular [obs] small, Burkitt type [obs] (includes all variants) small cell, diffuse [obs] non-Hodgkin, NOS non-Hodgkin and Hodgkin, composite null cell and T-cell type anaplastic large cell Alphabetic Index M-9708/3 Lymphoma, continued panniculitis-like T-cell lymphoma, subcutaneous M-9670/3 M-9670/3 M-9702/3 Peripheral T-cell NOS AILD (Angioimmunoblastic Lymphadenopathy with Dysproteinemia) [obs] large cell pleomorphic medium and large cell pleomorphic small cell M-9684/3 M-9671/3 M-9671/3 plasmablastic plasmacytic [obs] plasmacytoid [obs] M-9689/3 M-9689/3 M-9689/3 M-9702/3 pleomorphic medium and large cell, peripheral T-cell pleomorphic small cell, peripheral T-cell M-9708/3 M-9702/3 M-9705/3 M-9702/3 M-9702/3 M-9702/3 M-9728/3 M-9727/3 M-9729/3 M-9718/3 M-9678/3 M-9591/3 M-9695/3 Poorly differentiated lymphocytic, diffuse [obs] lymphocytic, nodular [obs] M-9699/3 M-9699/3 SALT Skin associated lymphoid tissue M-9675/3 M-9670/3 M-9691/3 M-9591/3 M-9591/3 M-9695/3 M-9687/3 M-9719/3 M-9702/3 M-9679/3 M-9755/3 T/NK-cell T-zone thymic large B-cell (C37.9) true histiocytic M-9714/3 M-9719/3 M-9705/3 M-9709/3 M-9717/3 M-9717/3 M-9717/3 M-9702/3 M-9729/3 M-9702/3 M-9702/3 M-9705/3 M-9702/3 M-9702/3 M-9702/3 M-9729/3 Cleaved and large cell, mixed, follicular [obs] cell, NOS [obs] cell, diffuse [obs] cleaved cell, follicular [obs] 194 subcutaneous panniculitis-like T-cell lymphoma M-9718/3 M-9680/3 M-9680/3 M-9708/3 M-9827/3 NOS (see also M-9823/3) diffuse (see also M-9823/3) noncleaved, diffuse [obs] pleomorphic, peripheral T-cell Splenic marginal zone, NOS (C42.2) marginal zone B-cell (C42.2) with villous lymphocytes (C42.2) T-cell NOS NOS, cutaneous (C44._) adult (includes all variants) adult T-cell leukemia/lymphoma (HTLV-1 positive) (includes all variants) adult T-cell lymphoma/leukemia (includes all variants) anaplastic large cell, T cell and Null cell type angiocentric [obs] angioimmunoblastic cutaneous, NOS (C44._) enteropathy associated enteropathy type intestinal intestinal large cell, peripheral lymphoblastic, precursor (see also M-9837/3) mature, NOS peripheral, NOS peripheral, AILD (Angioimmunoblastic Lymphadenopathy with Dysproteinemia) [obs] peripheral, large cell peripheral, pleomorphic medium and large cell peripheral, pleomorphic small cell precursor, lymphoblastic (see also M-9837/3) primary cutaneous CD30+ large rich/histiocyte-rich large B-cell rich large B-cell subcutaneous panniculitis-like M-9702/3 M-9709/3 M-9827/3 M-9827/3 Small and large cell, mixed, diffuse [obs] B lymphocytic, NOS (see also M-9823/3) Cell M-9670/3 M-9670/3 M-9591/3 M-9702/3 M-9670/3 Precursor B-cell lymphoblastic (see also M-9836/3) cell lymphoblastic, NOS (see also M-9835/3) T-cell lymphoblastic (see also M-9837/3) primary cutaneous anaplastic large-cell (C44._) primary cutaneous CD30+ large T-cell primary effusion M-9718/3 M-9670/3 Lymphoma, continued lymphocytic, NOS (see also M-9823/3) lymphocytic, B, NOS (see also M-9823/3) lymphocytic/B-cell chronic lymphocytic leukemia (see also M-9823/3) lymphocytic, diffuse, NOS (see also M-9823/3) noncleaved, Burkitt type [obs] (includes all variants) Alphabetic Index Lymphoma, continued Undifferentiated M-9687/3 Burkitt type [obs] (includes all variants) M-9591/3 cell, non-Burkitt [obs] M-9591/3 cell type, NOS [obs] M-9670/3 M-9598/3 Malignant lymphoma {see Lymphoma (malignant)} M---------/6 metastatic site (see behavior code, page 31) M---------/3 primary site (see behavior code, page 31) M---------/6 secondary site (see behavior code, page 31) M---------/9 uncertain whether primary or metastatic (see behavior code, page 31) M--------- Well-differentiated lymphocytic, diffuse (see also M-9823/3) lymphocytic, nodular [obs] M-9827/3 Lymphoma/leukemia, adult T-cell (includes all variants) M-9718/3 Lymphomatoid papulosis (C44._) M-8561/0 Lymphomatosum, papillary cystadenoma (C07._, C08._) M-9673/3 Lymphomatous polyposis, malignant (includes all variants: blastic, pleomorphic, small cell) M-9530/0 Lymphoplasmacyte-rich meningioma (C70._) M-9768/1 M-9970/1 M-9718/3 M-9591/3 M-9820/3 M-9591/3 M-9699/3 MALT lymphoma Mammary artery, internal M--------- Mammary duct ectasia (see SNOMED) C50.9 Mammary gland M-8540/3 Mammary Paget disease (C50._) Lymphoproliferative disease, T-gamma disorder, NOS disorder, primary cutaneous CD30+ T-cell (C44._) C41.1 C03.1 C77.0 Lymphosarcoma NOS [obs] cell leukemia [obs] diffuse [obs] C42.1 Main bronchus Major salivary gland, NOS M--------- Malakoplakia (see SNOMED) C63.9 C63.9 C63.9 Male genital organs, NOS genital tract, NOS genitourinary tract, NOS Marrow, bone M-8670/0 Masculinovoblastoma (C56.9) M--------- M_ (see Leukemia, FAB, M_) M-8334/0 Macrofollicular adenoma (C73.9) M-9761/3 Macroglobulinemia, Waldenstrom (C42.0) (see also M-9671/3) M-8726/0 Magnocellular nevus (C69.4) C34.0 C08.9 Mandible Mandibular gingiva Mandibular lymph node M-9673/3 Mantle zone lymphoma [obs] M M-8110/0 M-8742/2 M-8742/3 M-8000/3 M--------/1 C49.3 C49.0 Masseter muscle M-9741/3 M-9742/3 M-9740/3 M-9740/1 M-9740/3 Mast cell disease, systemic tissue leukemia (C42.1) sarcoma tumor, NOS tumor, malignant M-9740/1 Mastocytoma, NOS M-9740/3 Mastocytoma, malignant M-9741/3 Mastocytosis, malignant C30.1 Mastoid antrum M-8110/3 Matrical carcinoma (C44._) M-9080/0 Mature teratoma Malherbe calcifying epithelioma (C44._) Maligna, lentigo (C44._) Maligna melanoma, lentigo (C44._) Malignancy Malignancy, borderline (see behavior code, page 31) 195 C41.0 Maxilla C31.0 C03.0 C31.0 Maxillary antrum gingiva sinus C44.2 C17.3 C40.2 C47.1 C77.1 Meatus, external auditory Meckel diverticulum (site of neoplasm) Medial meniscus of knee joint Median nerve Mediastinal lymph node Alphabetic Index C38.3 C38.1 C38.2 M-8761/3 Melanocytic nevus, congenital, malignant melanoma in (C44._) Mediastinum NOS anterior posterior M-8726/0 M-8726/0 M-8728/1 M-9764/3 Mediterranean lymphoma C74.1 C71.7 Medulla of adrenal gland Medulla oblongata M-8510/3 M-8700/0 M-8700/3 Medullary adenocarcinoma adrenal, paraganglioma (C74.1) adrenal, paraganglioma, malignant (C74.1) M-8510/3 M-8513/3 M-8345/3 M-8512/3 M-9186/3 M-8700/0 M-8700/3 M-9750/3 M-8581/1 M-8581/3 M-8728/0 Melanocytosis, diffuse (C70.9) M-8720/3 M-8744/3 M-8730/3 M-8745/3 M-8722/3 M-8745/3 M-8745/3 M-8770/3 M-8771/3 M-8720/2 M-8770/0 M-8744/3 M-8742/3 Carcinoma NOS atypical (C50._) with amyloid stroma (C73.9) with lymphoid stroma osteosarcoma (C40._, C41._) paraganglioma, adrenal (C74.1) paraganglioma, adrenal, malignant (C74.1) reticulosis, histiocytic [obs] thymoma, NOS (C37.9) thymoma, malignant (C37.9) M-8746/3 M-8745/3 M-8721/3 M-8723/3 mucosal lentiginous neurotropic, malignant (C44._) nodular (C44._) regressing, malignant (C44._) M-8772/3 M-8770/3 M-8773/3 M-8774/3 Spindle cell NOS and epithelioid, mixed type A (C69._) type B (C69._) superficial spreading (C44._) M-8761/3 M-8742/3 M-8740/3 M-8741/3 M-9506/1 Medullocytoma (C71.6) M-9501/3 M-9501/0 M-9502/3 M-9502/0 M-8745/3 M-8723/3 M-9044/3 M-8744/3 M-8745/3 M-8761/3 Medulloblastoma NOS (C71.6) desmoplastic (C71.6) desmoplastic nodular (C71.6) large cell (C71.6) lipomatous (C71.6) melanotic (C71.6) Medulloepithelioma NOS benign (C69.4) teratoid (C69.4) teratoid, benign (C69.4) M-9472/3 Medullomyoblastoma (C71.6) Melanoma NOS acral lentiginous, malignant (C44._) amelanotic (C44._) amelanotic, desmoplastic (C44._) balloon cell (C44._) desmoplastic, amelanotic (C44._) desmoplastic, malignant (C44._) epithelioid and spindle cell, mixed epithelioid cell in situ juvenile (C44._) lentiginous, acral, malignant (C44._) lentigo maligna (C44._) Malignant NOS (except juvenile melanoma M-8770/0) acral lentiginous (C44._) desmoplastic (C44._) in congenital melanocytic nevus (C44._) in giant pigmented nevus (C44._) in Hutchinson melanotic freckle (C44._) in junctional nevus (C44._) in precancerous melanosis (C44._) neurotropic (C44._) regressing (C44._) soft parts (C49._) M-8720/3 M-8346/3 Medullary-follicular carcinoma, mixed (C73.9) M-8347/3 Medullary-papillary carcinoma, mixed (C73.9) M-9470/3 M-9471/3 M-9471/3 M-9474/3 M-9506/1 M-9470/3 Melanocytoma NOS eyeball (C69.4) meningeal (C70.9) Megakaryocytic leukemia (C42.1) leukemia, acute (C42.1) myelosclerosis (C42.1) M-8743/3 M-9910/3 M-9910/3 M-9961/3 C44.1 Meibomian gland M--------M-8741/2 M-8741/3 M-8728/3 Melanomatosis, meningeal (C70.9) M-9363/0 Melanoameloblastoma (C40._, C41._) M-8720/0 Melanocytic nevus (C44._) 196 Melanosis congenital (see SNOMED) precancerous, NOS (C44._) precancerous, malignant melanoma in (C44._) Alphabetic Index M-8742/2 M-8742/3 M-9470/3 M-9540/3 M-9540/3 M-9363/0 M-9541/0 M-9363/0 M-9540/3 M-9560/0 M-8247/3 Merkel cell carcinoma (C44._) M-8247/3 Merkel cell tumor (C44._) Melanotic freckle, Hutchinson, NOS (C44._) freckle, Hutchinson, malignant melanoma in (C44._) medulloblastoma (C71.6) MPNST MPNST, psammomatous neuroectodermal tumor neurofibroma progonoma psammomatous MPNST schwannoma M-9240/3 M-9540/3 M--------M-8990/3 M-8800/3 M-8990/1 Mesenchymal chondrosarcoma differentiation, MPNST with hamartoma (see SNOMED) sarcoma, mixed tumor, malignant tumor, mixed M-8990/1 M-8990/0 M-8990/3 Mesenchymoma NOS benign malignant C49.4 Mesenteric artery C58.9 Membranes, fetal M-8728/1 M-8728/3 M-9530/3 M-9539/3 Meningeal melanocytoma (C70.9) melanomatosis (C70.9) sarcoma (C70._) sarcomatosis (C70._) C70.9 C70.0 C70.0 C70.0 C70.1 Meninges NOS cerebral cranial intracranial spinal C77.2 C77.2 C77.2 Mesenteric lymph node NOS inferior superior C48.1 C48.1 Mesentery Mesoappendix Meningioma (C70._) NOS anaplastic angioblastic [obs] angiomatous atypical chordoid clear cell endotheliomatous fibroblastic fibrous hemangioblastic [obs] hemangiopericytic [obs] lymphoplasmacyte-rich malignant meningothelial metaplastic microcytic mixed papillary psammomatous rhabdoid secretory syncytial transitional M-8960/1 Mesoblastic nephroma M-9530/0 M-9530/3 M-9535/0 M-9534/0 M-9539/1 M-9538/1 M-9538/1 M-9531/0 M-9532/0 M-9532/0 M-9535/0 M-9150/1 M-9530/0 M-9530/3 M-9531/0 M-9530/0 M-9530/0 M-9537/0 M-9538/3 M-9533/0 M-9538/3 M-9530/0 M-9531/0 M-9537/0 M-9530/1 M-9530/1 M-9530/1 M-9531/0 M-9530/3 Meningiomas, multiple (C70._) Meningiomatosis, NOS (C70._) Meningiomatosis, diffuse (C70._) Meningothelial meningioma (C70._) Meningothelial sarcoma (C70._) C40.2 C40.2 Meniscus, lateral of knee joint Meniscus, medial of knee joint M-8822/1 Mesenteric fibromatosis (C48.1) C48.1 Mesocolon M-8951/3 Mesodermal mixed tumor M-9110/3 M-9110/0 M-9110/1 Mesonephric adenocarcinoma adenoma tumor, NOS M-8310/3 Mesonephroid clear cell adenocarcinoma M-9110/3 M-9110/0 M-9110/3 Mesonephroma NOS benign malignant C10.9 C10.2 C10.3 Mesopharynx NOS lateral wall posterior wall M-9052/0 Mesothelial papilloma M-9050/3 M-9050/0 M-9053/3 M-9053/3 M-9055/1 197 Mesothelioma NOS benign biphasic, NOS biphasic, malignant cystic, NOS (C48._) Alphabetic Index M-9055/0 M-9051/3 Mesothelioma, continued cystic, benign (C48._) desmoplastic M-9052/3 M-9052/0 M-9052/3 Epithelioid NOS benign malignant M-9051/3 M-9051/0 M-9051/3 Fibrous NOS benign malignant M-9050/3 M-9055/0 M-9052/0 M-9051/3 M-9051/3 C57.1 C40.1 M-8202/0 M-8441/0 M-8407/3 M-9530/0 M-8333/0 Microfollicular adenoma (C73.9) M-9590/3 Microglioma (C71._) [obs] M-8076/3 Microinvasive squamous cell carcinoma (C53._) M-8097/3 Micronodular basal cell carcinoma (C44._) malignant multicystic, benign papillary, well differentiated, benign sarcomatoid spindled Mesovarium Metacarpal bone M-8325/0 Metanephric adenoma (C64.9) M--------- Metaphyseal fibrous defect (see SNOMED) M--------M-9961/3 M-8573/3 M-8573/3 M-8571/3 M-8571/3 M--------M--------M-9961/3 M-9961/3 M-8571/3 M-8572/3 M--------M-8570/3 M-8575/3 M-9530/0 M-8898/1 M--------/6 Metaplasia NOS (see SNOMED) agnogenic myeloid apocrine, adenocarcinoma with apocrine, carcinoma with cartilaginous, adenocarcinoma with cartilaginous and osseous, adenocarcinoma with glandular (see SNOMED) myeloid (see SNOMED) myeloid, with myelofibrosis myeloid, with myelosclerosis osseous, adenocarcinoma with spindle cell, adenocarcinoma with squamous (see SNOMED) squamous, adenocarcinoma with M-8140/6 M-8010/6 M-8000/6 M-8490/6 M-8070/6 M-8000/6 C40.3 Metatarsal bone M-8507/2 M-8507/2 M-8460/3 M-8131/3 Micropapillary carcinoma, intraductal (C50._) ductal carcinoma in situ (C50._) serous carcinoma (C56.9) transitional cell carcinoma (C67._) C71.7 C77.2 Midbrain Midcolic lymph node C71.9 C30.1 C34.2 C34.2 C15.4 Middle cranial fossa ear lobe, bronchus lobe, lung third of esophagus C50.8 C02.0 Midline of breast Midline of tongue M-9719/3 Midline reticulosis, malignant [obs] M-8335/3 Minimally invasive follicular carcinoma (C73.9) C06.9 Minor salivary gland, NOS (see coding guidelines page 38 and note under C08) M-8593/1 Minor sex cord elements, stromal tumor with (C56.9) M-8281/0 M-8281/3 M-8154/3 M-8560/3 Metaplastic carcinoma, NOS Metaplastic meningioma (C70._) Metastasizing leiomyoma Metastatic site, malignant (see behavior code, page 31) Metastatic adenocarcinoma, NOS carcinoma, NOS neoplasm signet ring cell carcinoma squamous cell carcinoma, NOS tumor Microcystic adenoma (C25._) adenoma, serous adnexal carcinoma (C44._) meningioma (C70._) M-8560/3 M-8244/3 M-8213/0 M-8902/3 M-8094/3 M-8281/0 M-8281/3 M-8180/3 M-8095/3 Metatypical carcinoma (C44._) M-9765/1 MGUS M-8341/3 Microcarcinoma, papillary (C73.9) M-8244/3 198 Mixed acidophil-basophil adenoma (C75.1) acidophil-basophil carcinoma (C75.1) acinar-endocrine carcinoma (C25._) adenocarcinoma and epidermoid carcinoma adenocarcinoma and squamous cell carcinoma adenocarcinoma-carcinoid adenomatous and hyperplastic polyp (C18._) alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma basal-squamous cell carcinoma (C44._) basophil-acidophil adenoma (C75.1) basophil-acidophil carcinoma (C75.1) bile duct and hepatocellular carcinoma (C22.0) carcinoid-adenocarcinoma Alphabetic Index Mixed, continued Cell M-8323/3 adenocarcinoma M-8323/0 adenoma M-8375/0 adrenal cortical adenoma (C74.0) M-8523/3 M-8154/3 M-9081/3 M-8902/3 M-8154/3 M-8154/3 M-9383/1 M-8560/3 M-8770/3 M-8154/3 M-8346/3 M-9085/3 M-8560/0 M-9382/3 M-8180/3 M-8213/0 M-8523/3 M-8524/3 M-8154/3 M-8855/3 M-8524/3 M-8346/3 M-8347/3 M-9537/0 M-8990/3 M-8990/1 M-8951/3 M-8254/3 M-8950/3 M-8254/3 M-8347/3 M-9362/3 M-9362/3 M-8902/3 M-9085/3 M-8592/1 M-8045/3 M-8770/3 duct, infiltrating, with other types of carcinoma (C50._) ductal-endocrine carcinoma (C25._) embryonal carcinoma and teratoma embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma endocrine-acinar carcinoma (C25._) endocrine-ductal carcinoma (C25._) ependymoma-subependymoma (C71._) epidermoid carcinoma and adenocarcinoma epithelioid and spindle cell melanoma exocrine and islet cell adenocarcinoma (C25._) follicular-medullary carcinoma (C73.9) germ cell tumor glandular and squamous cell papilloma glioma (C71._) hepatocellular and bile duct carcinoma (C22.0) hyperplastic and adenomatous polyp (C18._) infiltrating duct with other types of carcinoma (C50._) infiltrating lobular with other types of carcinoma (C50._) islet cell and exocrine adenocarcinoma (C25._) liposarcoma lobular, infiltrating, with other types of carcinoma (C50._) medullary-follicular carcinoma (C73.9) medullary-papillary carcinoma (C73.9) meningioma (C70._) mesenchymal sarcoma mesenchymal tumor mesodermal tumor mucinous and non-mucinous bronchiolo-alveolar carcinoma, (C34._) Mullerian tumor (C54._) non-mucinous and mucinous bronchiolo-alveolar carcinoma, (C34._) papillary-medullary carcinoma (C73.9) pineal tumor (C75.3) pineocytoma-pineoblastoma (C75.3) rhabdomyosarcoma, alveolar and embryonal seminoma and teratoma M-8560/0 M-8560/3 M-8094/3 M-9383/1 M-8255/3 M-9081/3 M-9085/3 M-8940/0 M-8940/3 M-8951/3 M-8950/3 M-9362/3 M-8940/0 M-8940/3 M-8902/3 M-8582/1 M-8582/3 Mixed, continued sex cord-gonadal stromal tumor, mixed forms small cell carcinoma spindle cell and mixed epithelioid melanoma squamous cell and glandular papilloma squamous cell carcinoma and adenocarcinoma squamous-basal cell carcinoma (C44._) subependymoma-ependymoma (C71._) subtypes, adenocarcinoma with teratoma and embryonal carcinoma teratoma and seminoma Tumor NOS malignant, NOS mesodermal Mullerian (C54._) pineal (C75.3) salivary gland type, NOS (C07._, C08._) salivary gland type, malignant (C07._, C08._) Type rhabdomyosarcoma thymoma, NOS (C37.9) thymoma, malignant (C37.9) M-8453/1 Moderate dysplasia, intraductal papillarymucinous tumor with (C25._) M-8470/1 Moderate dysplasia, mucinous cystic tumor with (C25._) M-------/-2 Moderately differentiated (see grading code, page 34) M-8332/3 Moderately differentiated, follicular adenocarcinoma (C73.9) M-8332/3 Moderately differentiated, follicular carcinoma (C73.9) M-------/-2 Moderately well differentiated (see grading code, page 34) M-9100/0 Mole hydatid (C58.9) M-9100/0 M-9100/0 M-9100/1 M-9100/1 M-9103/0 Hydatidiform NOS (C58.9) complete (C58.9) invasive (C58.9) malignant (C58.9) partial (C58.9) M-9100/1 invasive, NOS (C58.9) M--------- Molluscum contagiosum (see SNOMED) M--------- Molluscum sebaceum (see SNOMED) M-9765/1 Monoclonal gammopathy, NOS 199 Alphabetic Index M-9765/1 Monoclonal gammopathy of undetermined significance M-8146/0 Monomorphic adenoma M-9752/1 Mono-ostotic Langerhans cell histiocytosis M-9041/3 Monophasic fibrous synovial sarcoma C51.9 C51.9 Mucinous, continued Cystadenofibroma M-9015/0 NOS M-9015/3 malignant M-9015/1 of borderline malignancy Mons pubis Mons veneris M-9441/3 Monstrocellular sarcoma (C71._) [obs] M-8092/3 Morpheic basal cell carcinoma (C44._) C06.9 C04.9 C04.0 C04.1 C05.9 C06.1 Mouth NOS floor, NOS floor, anterior floor, lateral roof vestibule M-9540/3 M-9540/3 M-9540/3 M-9540/3 M-9571/3 M-9540/3 M-9540/3 MPNST NOS epithelioid melanotic melanotic psammomatous perineural with glandular differentiation with mesenchymal differentiation Mucinous adenocarcinofibroma adenocarcinoma adenocarcinoma, endocervical type M-9015/0 M-9015/3 M-9015/1 Adenofibroma NOS malignant of borderline malignancy M-8243/3 M-8480/3 M-9015/3 adenoma and infiltrating duct carcinoma (C50._) bronchiolo-alveolar carcinoma (C34._) bronchiolo-alveolar carcinoma, nonmucinous and, mixed (C34._) carcinoid carcinoma cystadenocarcinofibroma M-8470/3 M-8470/2 M-8471/3 Cystadenocarcinoma NOS (C56.9) non-invasive (C25._) papillary (C56.9) M-8480/0 M-8523/3 M-8253/3 M-8254/3 Cystadenoma NOS (C56.9) borderline malignancy (C56.9) papillary, NOS (C56.9) papillary, borderline malignancy (C56.9) M-8470/0 cystoma (C56.9) M-8472/1 M-8472/1 M-8472/1 M-8470/1 M-8473/1 Tumor NOS, of low malignant potential (C56.9) atypical proliferative (C56.9) cystic, of borderline malignancy (C56.9) cystic, with moderate dysplasia (C25._) papillary, of low malignant potential (C56.9) Mucinous-papillary adenoma, intraductal (C25._) carcinoma, intraductal, invasive (C25._) M-8453/2 carcinoma, intraductal, non-invasive (C25._) M-8453/1 tumor, intraductal, with moderate dysplasia (C25._) M-8453/0 M-8453/3 M-9762/3 Mu heavy chain disease M-8230/3 Mucin formation, solid adenocarcinoma with M-8230/3 Mucin formation, solid carcinoma with M-8481/3 Mucin-producing adenocarcinoma M-8481/3 Mucin-producing carcinoma M-8481/3 Mucin-secreting adenocarcinoma M-8481/3 Mucin-secreting carcinoma M-9015/3 M-8480/3 M-8482/3 M-8470/0 M-8472/1 M-8471/0 M-8473/1 M-8243/3 M--------M-8430/3 M-8430/1 Mucocarcinoid tumor Mucocele (see SNOMED) Mucoepidermoid carcinoma Mucoepidermoid tumor [obs] M-8480/3 M-8480/3 M-8300/3 M-8300/0 Mucoid adenocarcinoma carcinoma cell adenocarcinoma (C75.1) cell adenoma (C75.1) C03.9 C03.1 C03.0 C03.9 C03.1 C03.0 C06.0 C06.0 C00.5 C00.4 C00.3 C30.0 C06.9 Mucosa alveolar, NOS alveolar, lower alveolar, upper alveolar ridge, NOS alveolar ridge, lower alveolar ridge, upper buccal cheek lip, NOS lip, lower lip, upper nasal oral M-8746/3 Mucosal lentiginous melanoma M-8480/3 Mucous adenocarcinoma 200 Alphabetic Index M-8480/3 M-8950/3 M-8091/3 M-9055/0 M-9753/1 M-8091/3 M-9440/3 M-9440/3 M-9985/3 M-8959/3 M-8360/1 M-8221/0 M-8221/3 M-9140/3 M-9530/1 M-9732/3 M-9540/1 M-8221/0 M-8221/3 Mucous carcinoma Mullerian mixed tumor (C54._) Multicentric basal cell carcinoma (C44._) Multicystic mesothelioma, benign Multifocal Langerhans cell histiocytosis Multifocal superficial basal cell carcinoma (C44._) Multiforme, glioblastoma (C71._) Multiforme, spongioblastoma (C71._) Multilineage dysplasia, refractory cytopenia with Multilocular cystic nephroma, malignant (C64.9) C49.4 C49.2 C49.4 C49.5 C49.0 C49.1 C49.9 C49.0 C49.2 C49.3 C49.3 C49.1 C49.2 C49.3 C49.1 C49.6 Multiple adenomas, endocrine adenomatous polyps adenomatous polyps, adenocarcinoma in hemorrhagic sarcoma meningiomas (C70._) myeloma (C42.1) neurofibromatosis polyps, adenomatous polyps, adenomatous, adenocarcinoma in C75.8 C77.8 Multiple endocrine glands Multiple regions, lymph nodes C49.9 C49.4 C49.4 C49.1 C49.6 C49.1 C49.2 C49.1 C49.5 C49.2 C49.3 C49.1 C49.1 C69.6 C49.0 C49.1 C49.6 C49.2 C49.1 C49.2 C49.5 C49.1 C49.0 C49.4 C49.3 C49.3 C49.2 C49.0 C49.0 C49.3 C49.5 C49.5 Muscle NOS abdomen abdominal wall arm back biceps brachii biceps femoris brachialis buttock calf chest wall coracobrachialis deltoideus extraocular face finger flank foot forearm gastrocnemius gluteus maximus hand head iliopsoas intercostal latissimus dorsi leg masseter neck pectoralis major pelvis perineum Muscle, continued psoas quadriceps femoris rectus abdominis sacrococcygeal region scalp shoulder skeletal, NOS sternocleidomastoid thigh thoracic wall thorax thumb toe trapezius triceps brachii trunk, NOS M-8897/1 Muscle tumor, smooth, NOS M-8897/1 Muscle tumor, smooth, uncertain malignant potential M--------- Musculo-aponeurotic fibromatosis (see SNOMED) M-9700/3 Mycosis fungoides (C44._) Myelodysplastic syndrome NOS alkylating agent related, therapy related M-9987/3 epipodophyllotoxin related, therapy related M-9895/3 prior, acute myeloid leukemia with M-9895/3 prior, acute myeloid leukemia without M-9989/3 M-9987/3 M-9987/3 M-9987/3 M-9987/3 Therapy related NOS alkylating agent related epipodophyllotoxin related M-9986/3 with 5q deletion (5q–) syndrome Myelofibrosis NOS (see SNOMED) acute (C42.1) as a result of myeloproliferative disease M-9961/3 chronic idiopathic M-9961/3 with myeloid metaplasia M-9931/3 with panmyelosis (C42.1) M--------M-9931/3 M-9961/3 Myeloid Metaplasia M-9961/3 agnogenic M-9961/3 with myelofibrosis M-9961/3 with myelosclerosis M-9930/3 sarcoma (see also M-9861/3) M-8870/0 Myelolipoma 201 Alphabetic Index M-9732/3 M-9732/3 M-9732/3 M-9731/3 Myeloma NOS (C42.1) multiple (C42.1) plasma cell (C42.1) solitary (C42.1) M-8852/3 M-8852/0 Myxolipoma M-8852/3 Myxoliposarcoma M-9732/3 Myelomatosis (C42.1) M-9975/1 M-9960/3 M-9961/3 M-8840/0 M-9562/0 M-9320/0 Myeloproliferative disease NOS chronic (C42.1) myelofibrosis as a result of Myelosclerosis acute, NOS (C42.1) malignant (C42.1) [obs] megakaryocytic with myeloid metaplasia M-9840/3 M-9840/3 M-9580/0 M-9580/3 Myelosis, erythremic, NOS (C42.1) Myelosis, erythremic, acute [obs] Myoblastoma, granular cell, NOS Myoblastoma, granular cell, malignant C38.0 Myocardium M-8982/0 M-8982/3 M-8982/0 Myoepithelial adenoma carcinoma tumor N C53.0 C44.6 C44.7 C30.0 M-8825/1 M-8825/1 M-8827/1 M-8827/1 M-8825/0 M-8824/0 M-8824/1 M-8824/1 M-8895/0 Myofibroblastoma Myofibroma Myofibromatosis Myofibromatosis, infantile Myoma C54.2 Myometrium M-8895/3 M-8931/3 M-8931/3 M---------M-8811/0 M-9320/0 Myosarcoma Myosis, stromal, NOS (C54.1) Myosis, stromal, endolymphatic (C54.1) Myositis ossificans, NOS (see SNOMED) Myxofibroma, NOS Myxofibroma, odontogenic (C41._) M-9231/3 M-8811/0 M-8896/3 Myxoid chondrosarcoma fibroma leiomyosarcoma 202 Nabothian gland Nail, finger Nail, toe Naris C11.3 C31.9 C30.0 Nasal bone cartilage cavity (excludes nose, NOS C76.0) lacrimal duct mucosa septum, NOS (excludes posterior margin of nasal septum C11.3) septum, posterior margin sinus, accessory turbinate M--------M--------- Nasal glial heterotopia (see SNOMED) Nasal glioma (see SNOMED) C69.5 C69.5 Nasal lacrimal duct Nasolacrimal duct M--------- Nasopalatine duct cyst (see SNOMED) C11.3 C11.9 Nasopharyngeal surface, soft palate Nasopharyngeal wall C11.9 C11.3 C11.2 C11.1 C11.0 C11.0 Nasopharynx NOS anterior wall lateral wall posterior wall roof superior wall C76.0 C44.4 C49.0 C49.0 C47.0 C49.0 C49.0 Neck NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue C41.0 C30.0 C30.0 C69.5 C30.0 C30.0 M-8562/3 Myoepithelial-epithelial carcinoma M-8982/0 Myoepithelioma M-8982/3 Myoepithelioma, malignant Myofibroblastic tumor NOS inflammatory peribronchial (C34._) peribronchial, congenital (C34._) Myxoma NOS nerve sheath odontogenic (C41._) M-9394/1 Myxopapillary ependymoma (C72.0) M-8840/3 Myxosarcoma M-9960/3 Myeloproliferative disorder, chronic M-9931/3 M-9931/3 M-9961/3 M-9961/3 Myxoid, continued liposarcoma Alphabetic Index C49.0 C77.0 C49.0 C47.0 C49.0 C44.4 C49.0 C49.0 C49.0 C49.0 Neck, continued fibrous tissue lymph node muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath C67.5 C25.7 Neck, bladder Neck, pancreas M--------- Necrosis, fat (see SNOMED) M-8077/2 M-8077/2 M-8500/2 M-9064/2 M-8077/2 M-8077/2 M-8077/2 M-8000/1 M-8000/0 M-8000/3 M-8000/9 M-8000/6 M-8452/1 M-8130/1 M-8130/1 M-8000/6 M-8452/1 M-8000/1 C47.1 C72.5 C72.5 C47.2 C72.5 C72.5 C47.3 C47.6 C47.1 C47.2 C72.5 C72.2 C72.3 C47.9 C47.1 C47.5 C47.2 C47.9 C72.5 C72.5 C72.5 C47.1 C72.5 Neoplasia anal intraepithelial, grade III (C21.1) cervical intraepithelial, grade III (C53._) ductal intraepithelial 3 (C50._) intratubular germ cell (C62._) squamous intraepithelial, grade III vaginal intraepithelial, grade III (C52._) vulvar intraepithelial, grade III (C51._) M-9562/0 M-9540/3 M-9561/3 Neoplasm NOS benign malignant malignant, uncertain whether primary or metastatic metastatic papillary and solid epithelial (C25._) papillary transitional cell, low malignant potential (C67._) papillary urothelial, low malignant potential (C67._) secondary solid and papillary epithelial (C25._) uncertain whether benign or malignant M-8960/3 Nephroblastoma, NOS (C64.9) M-8959/1 Nephroblastoma, cystic partially differentiated C64.9) M-8965/0 Nephrogenic adenofibroma (C64.9) M-8960/3 M-8959/0 M-8959/3 M-8959/3 M-8960/1 Nephroma NOS (C64.9) cystic, benign (C64.9) cystic, malignant (C64.9) cystic, multilocular, malignant (C64.9) mesoblastic C47.9 C72.5 C72.5 C72.5 C72.4 Nerve NOS abducens accessory, NOS accessory, spinal acoustic 203 Nerve, continued brachial cranial, NOS facial femoral glossopharyngeal hypoglossal intercostal lumbar median obturator oculomotor olfactory optic peripheral, NOS radial sacral sciatic spinal, NOS spinal accessory trigeminal trochlear ulnar vagus Nerve sheath myxoma tumor, malignant peripheral tumor, malignant peripheral with rhabdomyoblastic differentiation C72.9 C47.9 C72.9 C47.9 C47.9 Nervous system NOS autonomic, NOS central parasympathetic, NOS sympathetic, NOS M-8150/0 M-9560/0 M-9560/3 M-9560/3 M-9560/0 M-9560/1 M-9505/1 Nesidioblastoma (C25._) Neurilemoma, NOS Neurilemoma, malignant [obs] Neurilemosarcoma [obs] Neurinoma Neurinomatosis Neuroastrocytoma [obs] M-9500/3 M-9500/3 M-9522/3 Neuroblastoma NOS central (C71._) olfactory (C30.0) M-9506/1 M-9506/1 M-9521/3 Neurocytoma NOS central olfactory (C30.0) M-9364/3 M-9473/3 M-9363/0 M-9364/3 M-9364/3 M-9473/3 Neuroectodermal tumor NOS central primitive, NOS (C71._) melanotic peripheral peripheral primitive, NOS primitive, NOS Alphabetic Index M-9473/3 Neuroectodermal tumor, continued primitive, central, NOS (C71._) M-8246/3 M-8013/3 M-8247/3 M-8041/3 M-8574/3 M-8574/3 Neuroendocrine carcinoma, NOS carcinoma, large cell carcinoma, primary cutaneous (C44._) carcinoma, small cell differentiation, adenocarcinoma with differentiation, carcinoma with M-8750/0 M-8760/0 M-8727/0 M-8770/0 M-8771/0 M--------M-8761/1 M-9413/0 Neuroepithelial tumor, dysembryoplastic M-9503/3 Neuroepithelioma, NOS M-9523/3 Neuroepithelioma, olfactory (C30.0) M-8761/1 M-8761/3 M-8730/0 M-8720/0 M-8761/1 M-8770/0 Pigmented NOS (C44._) giant, NOS (C44._) spindle cell, Reed M--------M-8770/0 M-8723/0 M--------M--------M-8761/0 M--------- portwine (see SNOMED) Reed pigmented spindle cell regressing (C44._) sanguineous (see SNOMED) sebaceus, Jadassohn (see SNOMED) small congenital (C44._) spider (see SNOMED) M-8772/0 M-8770/0 M-8770/0 Spindle cell NOS (C44._) and epithelioid cell (C44._) pigmented, Reed M-8770/0 M--------M--------M--------M--------M--------- Spitz (C44._) strawberry (see SNOMED) unius lateris (see SNOMED) vascular (see SNOMED) verrucosus (see SNOMED) white sponge (see SNOMED) Neurofibroma NOS melanotic plexiform M-9540/1 M-9540/1 M-9540/3 M-9540/3 M-9520/3 M-9506/1 Neurofibromatosis, NOS Neurofibromatosis, multiple Neurofibrosarcoma [obs] Neurogenic sarcoma [obs] Neurogenic tumor, olfactory Neurolipocytoma (C71.6) M-8750/0 M-8740/0 M-9160/0 M-8780/0 M--------M-8740/0 M-8740/0 M-8740/3 M-9570/0 M-9560/0 M--------M-9550/0 M--------- Neuroma NOS acoustic (C72.4) amputation (see SNOMED) plexiform traumatic (Morton) (see SNOMED) M-8770/0 M-8726/0 M-8720/0 M-8761/3 M-8725/0 M-9540/3 M-9562/0 M-8745/3 M--------- Neuronevus (C44._) Neurosarcoma [obs] Neurothekeoma Neurotropic melanoma, malignant (C44._) Nevoxanthoendothelioma (see SNOMED) M-8720/0 M-8730/0 M--------M-8722/0 Nevus NOS (C44._) achromic (C44._) araneus (see SNOMED) balloon cell (C44._) Blue NOS (C44._) cellular (C44._) Jadassohn (C44._) malignant (C44._) M-8760/0 compound (C44._) M-8761/1 M-8761/3 M-8762/1 M-8761/0 Congenital intermediate and giant (C44._) melanocytic, malignant melanoma in (C44._) proliferative dermal lesion in (C44._) small (C44._) C50.0 C------ 204 Giant and intermediate congenital (C44._) pigmented, NOS (C44._) pigmented, malignant melanoma in (C44._) hairy (C44._) halo (C44._) intermediate and giant congenital (C44._) intradermal (C44._) intraepidermal (C44._) involuting (C44._) [obs] Jadassohn blue (C44._) Jadassohn sebaceus (see SNOMED) junction (C44._) junctional, NOS (C44._) junctional, malignant melanoma in (C44._) juvenile (C44._) magnocellular (C69.4) melanocytic (C44._) melanocytic, congenital, malignant melanoma (C44._) nonpigmented (C44._) M-8720/0 M-8723/0 M-8761/1 M-9540/0 M-9541/0 M-9550/0 M-8780/0 M-8790/0 M-8780/0 M-8780/3 Nevus, continued dermal (C44._) dermal and epidermal (C44._) dysplastic (C44._) epithelioid and spindle cell (C44._) epithelioid cell (C44._) flammeus (see SNOMED) Nipple Node (see lymph node) Alphabetic Index Nodular basal cell carcinoma (C44._) fasciitis (see SNOMED) hidradenoma (C44._) hidradenoma, malignant (C44._) hyperplasia, NOS (see SNOMED) hyperplasia, focal (see SNOMED) medulloblastoma, desmoplastic (C71.6) M-8721/3 melanoma (C44._) M-8832/0 subepidermal fibrosis (C44._) M--------tenosynovitis (see SNOMED) M-8254/3 Non-mucinous and mucinous bronchioloalveolar carcinoma, mixed (C34._) M-8252/3 Non-mucinous bronchiolo-alveolar carcinoma (C34._) M-------- Nonossifying fibroma (see SNOMED) M-8730/0 Nonpigmented nevus (C44._) M-8092/3 Non-sclerosing infiltrating basal cell carcinoma (C44._) M-8046/3 Non-small cell carcinoma (C34._) M-------/-7 Non T-non B (see cell designation code, page 36) M-8930/0 Nodule, endometrial stromal (C54.1) M-8693/1 Nonchromaffin paraganglioma, NOS M-8693/3 Nonchromaffin paraganglioma, malignant C76.0 C44.3 C41.0 C30.0 C11.3 C44.3 C30.0 C30.0 C30.0 C41.0 C30.0 M-8097/3 M--------M-8402/0 M-8402/3 M--------M--------M-9471/3 M-8350/3 M-8350/3 M-8350/3 Nonencapsulated sclerosing adenocarcinoma (C73.9) carcinoma (C73.9) tumor (C73.9) Non-Hodgkin lymphoma {see lymphoma (malignant)} M-------/2 Noninfiltrating (see behavior code, page 31) M--------- M-8500/2 M-8503/2 Noninfiltrating adenocarcinoma, intraductal, NOS adenocarcinoma, intraductal, papillary (C50._) M-8504/2 M-8500/2 M-8503/2 M-8520/2 Carcinoma intracystic intraductal, NOS (C50._) intraductal papillary (C50._) lobular (C50._) M-8501/2 comedocarcinoma (C50._) C30.0 C30.0 C11.3 C44.3 C30.0 C30.0 Nose NOS ala nasi bone cartilage choana external internal mucosa naris nasal bone nasal cavity (excludes Nose, NOS C76.0) nostril septum, NOS septum, posterior margin skin turbinate vestibule C30.0 C41.2 Nostril Nucleus pulposus M-------/-7 Null cell (see cell designation code, page 36) M-------/2 Noninvasive (see behavior code, page 31) M-8453/2 M-8052/2 M-8130/2 M-8130/2 O Non-invasive carcinoma intraductal papillary-mucinous (C25._) papillary squamous cell papillary transitional cell (C67._) papillary urothelial (C67._) M-8042/3 Oat cell carcinoma (C34._) M-8470/2 Non-invasive cystadenocarcinoma, mucinous (C25._) M-8072/3 M-8073/3 M-8072/3 M-8072/3 M-8073/3 Nonkeratinizing epidermoid carcinoma, large cell epidermoid carcinoma, small cell Squamous cell carcinoma NOS large cell, NOS small cell C77.5 C47.2 Obturator lymph node Obturator nerve C41.0 C71.4 C77.0 C71.4 Occipital bone lobe lymph node pole C72.5 Oculomotor nerve M-9311/0 Odontoameloblastoma (C41._) M-9300/0 M-9270/3 M-9342/3 M-9754/3 Nonlipid reticuloendotheliosis [obs] 205 Odontogenic adenomatoid tumor (C41._) carcinoma (C41._) carcinosarcoma (C41._) Alphabetic Index M-8290/0 Oncocytoma M--------- Oncocytosis (see SNOMED) Odontogenic, continued Cyst M--------NOS (see SNOMED) M-9301/0 calcifying (C41._) M--------dentigerous (see SNOMED) M--------eruptive (see SNOMED) M--------gingival (see SNOMED) M--------primordial (see SNOMED) C71.0 Operculum C72.3 C72.3 C72.3 Optic chiasm nerve tract C06.9 C06.9 Oral cavity Oral mucosa M-9321/0 M-9321/0 M-9322/0 Fibroma NOS (C41._) central (C41._) peripheral (C41._) M-9330/3 M-9302/0 M-9320/0 M-9320/0 M-9270/3 fibrosarcoma (C41._) ghost cell tumor (C41._) myxofibroma (C41._) myxoma (C41._) sarcoma (C41._) C69.6 C69.6 C69.6 C69.6 C69.6 Orbit NOS autonomic nervous system connective tissue peripheral nerve soft tissue Tumor NOS (C41._) adenomatoid (C41._) benign (C41._) calcifying epithelial (C41._) clear cell (C44._) malignant (C41._) squamous (C41._) C41.0 Orbital bone M-9270/1 M-9300/0 M-9270/0 M-9340/0 M-9341/1 M-9270/3 M-9312/0 M-9280/0 M-9282/0 M-9281/0 M-9290/0 M-9071/3 Orchioblastoma (C62._) M-9290/3 Odontosarcoma, ameloblastic (C41._) Oesophagus (see esophagus) C72.2 Olfactory nerve M-9522/3 M-9521/3 M-9523/3 M-9520/3 Olfactory neuroblastoma (C30.0) neurocytoma (C30.0) neuroepithelioma (C30.0) neurogenic tumor (C30.0) M-9382/3 M-9382/3 M-9460/3 M-9450/3 M-9451/3 Oligoastrocytoma (C71._) Oligoastrocytoma, anaplastic (C71._) Oligodendroblastoma (C71._) [obs] Oligodendroglioma, NOS (C71._) Oligodendroglioma, anaplastic (C71._) C71.7 C48.1 Olive Omentum M-8290/3 M-8290/0 M-8290/3 M-8121/1 Oncocytic adenocarcinoma adenoma carcinoma Schneiderian papilloma (C30.0,C31._) Organ of Reil C75.5 Organ of Zuckerkandl M-8583/1 Organoid thymoma, NOS (C37.9) M-8583/3 Organoid thymoma, malignant (C37.9) Odontoma NOS (C41._) complex (C41._) compound (C41._) fibroameloblastic (C41._) C-------- C71.0 C26.9 C57.9 C63.9 Organs digestive, NOS female genital, NOS male genital, NOS C67.6 C67.5 Orifice, ureteric Orifice, urethral, internal C10.9 C10.8 C10.2 C10.3 Oropharynx NOS junctional region lateral wall posterior wall C53.1 C53.0 Os, external Os, internal Osseous dysplasia, florid (C41._) metaplasia, adenocarcinoma with (C41._) M-8571/3 metaplasia, adenocarcinoma with cartilaginous and (C41._) M-9275/0 M-8571/3 M-9262/0 M-8842/0 M-8967/0 Ossifying fibroma (C40._, C41._) fibromyxoid tumor renal tumor (C64.9) M--------- Osteitis deformans (see SNOMED) M--------- Osteitis fibrosa cystica (see SNOMED) M-9180/3 Osteoblastic sarcoma (C40._, C41._) 206 Alphabetic Index M-9200/0 Osteoblastoma, NOS (C40._, C41._) M-9200/1 Osteoblastoma, aggressive (C40._, C41._) M-9210/0 Osteocartilaginous exostosis (C40._, C41._) M-9210/0 Osteochondroma (C40._, C41._) M-9210/1 Osteochondromatosis, NOS (C40._, C41._) M--------- Osteochondromatosis, synovial (see SNOMED) M-9180/3 Osteochondrosarcoma (C40._, C41._) M-8035/3 Osteoclast-like giant cells, carcinoma with M-9250/1 Osteoclastoma, NOS (C40._, C41._) M-9250/3 Osteoclastoma, malignant (C40._, C41._) M-9262/0 Osteofibroma (C40._, C41._) M-9182/3 Osteofibrosarcoma (C40._, C41._) M-9180/3 Osteogenic sarcoma, NOS (C40._, C41._) M-9191/0 Osteoid osteoma, NOS (C40._, C41._) M-9200/0 Osteoid osteoma, giant (C40._, C41._) M-8290/3 M-8290/0 Cell M-8290/0 M-8290/3 M-8342/3 Osteoma NOS (C40._, C41._) osteoid, NOS (C40._, C41._) osteoid, giant (C40._, C41._) M-9180/3 M-9186/3 M-9186/3 M-9181/3 M-9182/3 M-9184/3 M-9195/3 M-9187/3 M-9187/3 M-9192/3 M-9186/3 M-9192/3 M-9193/3 M-9185/3 M-9185/3 M-9194/3 M-9183/3 Osteosarcoma NOS (C40._, C41._) central (C40._, C41._) central, conventional chondroblastic (C40._, C41._) fibroblastic (C40._, C41._) in Paget disease, bone (C40._, C41._) intracortical (C40._, C41._) intraosseous low grade intraosseous well differentiated juxtacortical (C40._, C41._) medullary (C40._, C41._) parosteal (C40._, C41._) periosteal (C40._, C41._) round cell small cell (C40._, C41._) surface, high grade (C40._, C41._) telangiectatic (C40._, C41._) M-8936/1 Pacemaker cell tumor, gastrointestinal M-9507/0 Pacinian tumor M-8543/3 M-------M-9184/3 M-8540/3 M-8542/3 M-8540/3 M-8590/1 Ovarian stromal tumor (C56.9) M-9090/0 Ovarii, struma (C56.9) M-9090/3 Ovarii, struma, malignant (C56.9) Ovary C----.8 Overlapping (see note, page 50, and coding guidelines, page 28) C11.3 Palate NOS hard junction of hard and soft soft, NOS (excludes nasopharyngeal surface C11.3) soft, nasopharyngeal surface C09.9 C71.0 C44.6 Palatine tonsil Pallium Palm, skin C49.1 C49.1 C44.6 Palmar aponeurosis fascia skin C44.1 Palpebra C25.9 C25.1 C25.3 C25.3 C25.3 C25.4 C25.0 C25.4 C25.4 C25.7 C25.2 Pancreas NOS body duct duct, Santorini duct, Wirsung endocrine head islands of Langerhans islets of Langerhans neck tail C05.9 C05.0 C05.8 C05.1 Outer breast Outer canthus C56.9 Paget disease and infiltrating duct carcinoma of breast (C50._) and intraductal carcinoma of breast (C50._) bone (see SNOMED) bone, osteosarcoma in (C40._, C41._) breast (C50._) extramammary (except Paget disease of bone) mammary (C50._) M-9700/3 Pagetoid reticulosis M-9101/3 Other germ cell elements, choriocarcinoma combined with M-8523/3 Other types of carcinoma, infiltrating duct mixed with (C50._) M-8524/3 Other types of carcinoma, infiltrating lobular mixed with (C50._) C50.8 C44.1 follicular adenoma (C73.9) follicular carcinoma (C73.9) papillary carcinoma (C73.9) P M-8541/3 M-9180/0 M-9191/0 M-9200/0 Oxyphilic adenocarcinoma adenoma 207 Alphabetic Index C25.3 C77.2 Pancreatic duct Pancreatic lymph node M-8450/3 M-8471/3 M-8471/3 M-8460/3 M-8971/3 Pancreatoblastoma (C25._) M-9931/3 Panmyelosis, acute, NOS (C42.1) M-9931/3 Panmyelosis with myelofibrosis (C42.1) M-8260/3 M-8408/3 M-8408/3 M-8340/3 M-8503/3 M-8504/3 M-8503/2 M-8503/3 M-8503/2 M-8460/3 Papillary Adenocarcinoma NOS digital (C44._) eccrine (C44._) follicular variant (C73.9) infiltrating (C50._) intracystic intraductal, NOS (C50._) intraductal, with invasion (C50._) noninfiltrating intraductal (C50._) serous (C56.9) M-9013/0 adenofibroma M-8260/0 M-8408/1 M-8408/0 M-8504/0 Adenoma NOS aggressive digital (C44._) eccrine (C44._) intracystic M-8340/3 M-8340/3 M-8503/3 M-8452/1 M-9135/1 M-8471/0 M-8473/1 M-8460/0 M-8462/1 M-8452/1 M-8462/1 M--------M-8503/2 M-8503/2 M-9135/1 M-9393/3 M-8052/3 M-8452/1 M-8340/3 and follicular adenocarcinoma and follicular carcinoma and infiltrating adenocarcinoma (C50._) and solid epithelial neoplasm (C25._) angioendothelioma, endovascular M-8461/3 M-8052/3 M-8052/2 M-8344/3 M-8260/3 M-8130/3 M-8130/2 Carcinoma NOS columnar cell (C73.9) diffuse sclerosing (C73.9) encapsulated (C73.9) epidermoid follicular variant (C73.9) in situ in situ, ductal (C50._) in situ, squamous cell intracystic intraductal, NOS (C50._) oxyphilic cell (C73.9) primary serous, peritoneum (C48.1) serous surface (C56.9) squamous cell squamous cell, non-invasive tall cell (C73.9) thyroid (C73.9) urothelial (C67._) urothelial, non-invasive (C67._) M-9352/1 craniopharyngioma (C75.2) M-8050/3 M-8344/3 M-8350/3 M-8343/3 M-8052/3 M-8340/3 M-8050/2 M-8503/2 M-8052/2 M-8504/3 M-8503/2 M-8342/3 M-8461/3 M-8450/0 M-8451/1 M-8561/0 M-8471/0 M-8473/1 M-8405/0 M-8504/3 M-8504/3 M-9538/3 M-9052/0 M-8341/3 M-8473/1 M-8461/3 M-8260/3 M-8460/3 M-8460/3 M-8462/1 M-8462/1 208 Papillary, continued Cystadenocarcinoma NOS (C56.9) mucinous (C56.9) pseudomucinous (C56.9) serous C56.9) Cystadenoma NOS (C56.9) borderline malignancy (C56.9) lymphomatosum (C07._, C08._) mucinous, NOS (C56.9) mucinous, borderline malignancy (C56.9) pseudomucinous, NOS (C56.9) pseudomucinous, borderline malignancy (C56.9) serous, NOS (C56.9) serous, borderline malignancy (C56.9) cystic tumor (C25._) cystic tumor, serous, borderline malignancy (C56.9) cystitis (see SNOMED) DCIS (C50._) ductal carcinoma in situ (C50._) endovascular, angioendothelioma ependymoma (C71._) epidermoid carcinoma epithelial neoplasm, solid and (C25._) follicular variant, adenocarcinoma (C73.9) hidradenoma (C44._) intracystic adenocarcinoma intracystic carcinoma meningioma (C70._) mesothelioma, well differentiated, benign microcarcinoma (C73.9) mucinous tumor of low malignant potential (C56.9) primary serous carcinoma, peritoneum (C48.1) renal cell carcinoma (C64.9) Serous adenocarcinoma (C56.9) cystadenocarcinoma (C56.9) tumor, atypical proliferative (C56.9) tumor, low malignant potential (C56.9) M-8052/3 M-8052/2 M-8052/2 Squamous cell carcinoma carcinoma in situ carcinoma, non-invasive M-8406/0 M-8406/0 syringadenoma (C44._) syringocystadenoma (C44._) Alphabetic Index Papillary, continued Transitional cell M-8130/3 carcinoma (C67._) M-8130/2 carcinoma, non-invasive (C67._) M-8130/1 neoplasm of low malignant potential (C67._) M-8130/3 M-8130/2 M-8130/1 Papilloma, continued Sinonasal M-8121/0 NOS (C30.0, C31._) M-8121/0 exophytic (C30.0, C31._) M-8121/0 fungiform (C30.0, C31._) Urothelial carcinoma (C67._) carcinoma, non-invasive (C67._) neoplasm of low malignant potential (C67._) M-8347/3 Papillary-medullary carcinoma, mixed (C73.9) Papillary-mucinous carcinoma, intraductal, invasive (C25._) M-8453/2 carcinoma, intraductal, non-invasive (C25._) M-8453/1 tumor, intraductal, with moderate dysplasia (C25._) M-8453/3 M--------M-8405/0 M-8406/0 M-8450/3 Papilliferous hyperplasia (see SNOMED) Papilliferum, hidradenoma (C44._) Papilliferum, syringocystadenoma Papillocystic adenocarcinoma Papilloma NOS (except papilloma of bladder M-8120/1) M--------basal cell (see SNOMED) M--------basosquamous (see SNOMED) M-8120/1 bladder (C67._) M-8050/0 M-9390/0 M-9390/3 M-9390/1 M-9390/3 Choroid plexus NOS (C71.5) anaplastic (C71.5) atypical (C71.5) malignant (C71.5) M-8121/1 M-8121/1 M-8503/0 M--------M-8260/0 M-8504/0 M-8503/0 M-8053/0 M-8052/0 M-9052/0 M-8560/0 columnar cell cylindrical cell (C30.0, C31._) ductal fibroepithelial (see SNOMED) glandular intracystic intraductal inverted squamous cell keratotic mesothelial mixed squamous cell and glandular M-8121/0 M-8121/1 M-8121/1 Schneiderian NOS (C30.0, C31._) inverted (C30.0, C31._) oncocytic (C30.0, C31._) M-8461/0 serous surface (C56.9) M-8052/0 squamous M-8052/0 M-8560/0 M-8053/0 Squamous cell NOS and glandular, mixed inverted M-8120/0 M-8120/1 M-8120/0 M-8121/1 M-8121/0 M-8121/1 M-8121/0 Transitional NOS cell, NOS cell, benign cell, inverted, NOS cell, inverted, benign inverted, NOS inverted, benign M-8120/1 M-8051/0 M-8261/0 urothelial, NOS (C67._) verrucous villous M-8060/0 M-8264/0 M-8505/0 M-8264/0 M-8505/0 M-8505/0 M-8060/0 M-8506/0 Papillomatosis NOS biliary (C22.1, C24.0) diffuse intraductal glandular intraductal, NOS intraductal, diffuse squamous subareolar duct (C50.0) M-8263/3 M-8263/0 M-9160/0 M-9718/3 Papillotubular adenocarcinoma Papillotubular adenoma Papule, fibrous, of nose (C44.3) [obs] Papulosis, lymphomatoid (C44._) C75.5 C77.2 C77.5 Para-aortic body Para-aortic lymph node Paracervical lymph node M-9373/0 Parachordoma M-8345/3 Parafollicular cell carcinoma (C73.9) M-8680/1 M-8700/0 M-8700/3 M-8691/1 M-8691/1 M-8680/0 M-8692/1 M-8700/0 M-8693/1 M-8693/3 M-8683/0 M-8690/1 M-8690/1 M-8680/3 209 Paraganglioma NOS adrenal medullary (C74.1) adrenal medullary, malignant (C74.1) aortic body (C75.5) aorticopulmonary (C75.5) benign carotid body (C75.4) chromaffin extra-adrenal, NOS extra-adrenal, malignant gangliocytic (C17.0) jugular (C75.5) jugulotympanic (C75.5) malignant Alphabetic Index M-8693/1 M-8693/3 M-8682/1 M-8681/1 Paraganglioma, continued nonchromaffin, NOS nonchromaffin, malignant parasympathetic sympathetic C75.5 Paraganglion M-9659/3 Paragranuloma, Hodgkin, NOS [obs] M-9659/3 Paragranuloma, Hodgkin, nodular [obs] C77.5 C57.3 C31.9 C72.9 C77.1 C47.9 Parametrial lymph node Parametrium Paranasal sinus Parasellar Parasternal lymph node Parasympathetic nervous system, NOS M-8682/1 Parasympathetic paraganglioma C75.0 C68.1 C64.9 Parathyroid gland Paraurethral gland Parenchyma, kidney M-9362/3 Parenchymal tumor, pineal, intermediate differentiation (C75.3) C41.0 C71.3 C38.4 Parietal bone lobe pleura M-9192/3 Parosteal osteosarcoma (C40._, C41._) Parotid NOS gland gland duct lymph node C57.1 Parovarian region Pelvis NOS NOS (sarcoma, lipoma) autonomic nervous system bone connective tissue fibrous tissue muscle peripheral nerve skeletal muscle soft tissue wall, NOS C65.9 C65.9 C65.9 Pelvis, kidney Pelvis, renal Pelviureteric junction C60.9 C60.2 C60.2 C60.2 C60.0 C60.1 C60.0 C60.9 Penis NOS body corpus corpus cavernosum foreskin glans prepuce skin C48.0 C24.1 C44.5 C77.2 Periadrenal tissue Periampullary Perianal skin Periaortic lymph node M-9272/0 Periapical cemental dysplasia (C41._) M-9272/0 Periapical cemento-osseous dysplasia (C41._) M-8827/1 Peribronchial myofibroblastic tumor, (C34._) M-8827/1 Peribronchial myofibroblastic tumor, congenital (C34._) M-9012/0 Pericanalicular fibroadenoma (C50._) M-8214/3 Parietal cell adenocarcinoma (C16._) M-8214/3 Parietal cell carcinoma (C16._) C07.9 C07.9 C07.9 C77.0 C76.3 C49.5 C47.5 C41.4 C49.5 C49.5 C49.5 C47.5 C49.5 C49.5 C76.3 C38.0 Pericardium M-8391/0 Perifollicular fibroma (C44._) M-9103/0 Partial hydatidiform mole (C58.9) M-8959/1 Partially differentiated nephroblastoma, cystic (C64.9) C48.0 Perinephric tissue Perineum NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system connective tissue fibrous tissue peripheral nerve muscle skeletal muscle skin soft tissue subcutaneous tissue C40.3 C77.3 C49.3 C71.7 Patella Pectoral lymph node Pectoralis major muscle Peduncle, cerebral C41.4 C18.7 C77.5 C48.1 C76.3 Pelvic bone colon lymph node peritoneum wall, NOS C76.3 C44.5 C49.5 C47.5 C49.5 C49.5 C47.5 C49.5 C49.5 C44.5 C49.5 C49.5 C19.9 Pelvirectal junction M-9571/3 Perineural MPNST 210 Alphabetic Index M-9571/0 M-9571/0 M-9571/3 M-9571/0 Perineurioma NOS intraneural malignant soft tissue C03.9 Periodontal tissue M-9221/0 M-9221/3 M-8812/0 M-8812/3 M-9193/3 M-8812/3 Periosteal chondroma (C40._, C41._) chondrosarcoma (C40._, C41._) fibroma (C40._, C41._) fibrosarcoma (C40._, C41._) osteosarcoma (C40._, C41._) sarcoma, NOS (C40._, C41._) C77.2 C48.0 Peripancreatic lymph node Peripancreatic tissue Peripheral nerve sheath tumor, malignant nerve sheath tumor with rhabdomyoblastic differentiation, malignant M-9364/3 neuroectodermal tumor M-9322/0 odontogenic fibroma (C41._) M-9540/3 M-9561/3 C47.9 C47.4 C47.4 C47.2 C47.1 C47.1 C47.3 C47.6 C47.5 C47.2 C47.0 C47.0 C47.3 C47.3 C47.0 C47.1 C47.0 C47.1 C47.6 C47.2 C47.1 C47.0 C47.5 C47.5 C47.1 C47.0 C47.2 C47.2 C47.3 C47.5 C47.2 C47.2 C47.0 C69.6 C47.5 C47.1 C47.2 C47.6 C47.4 C47.1 Peripheral nerve, continued perineum popliteal space pterygoid fossa sacrococcygeal region scalp scapular region shoulder supraclavicular region temple thigh thoracic wall thorax (excludes thymus, heart and mediastinum C37._, C38._) thumb toe trunk umbilicus wrist C76.3 C48.0 C48.2 Perirectal region, NOS Perirenal tissue Peritoneal cavity C47.5 C47.2 C47.0 C47.5 C47.0 C47.3 C47.1 C47.0 C47.0 C47.2 C47.3 C47.3 M-8480/6 Peritonei, pseudomyxoma M-8480/3 Peritonei, pseudomyxoma, with unknown primary site (C80.9) Peripheral nerve NOS abdomen abdominal wall ankle antecubital space arm axilla back buttock calf cervical region cheek chest chest wall chin elbow face finger flank foot forearm forehead gluteal region groin hand head heel hip infraclavicular region inguinal region knee leg neck orbit pelvis C48.2 C48.2 C48.1 C48.1 C48.1 C48.1 C48.1 C48.1 C48.1 C48.1 Peritoneum NOS cavity cul de sac mesentery mesoappendix mesocolon omentum pelvic pouch, Douglas pouch, rectouterine M--------- Peutz-Jeghers polyp (see SNOMED) C40.3 C40.1 Phalanx of foot Phalanx of hand C11.3 C11.1 C14.0 Pharyngeal fornix tonsil wall, NOS C14.0 C14.0 C14.0 C14.0 Pharynx NOS wall, NOS wall, lateral, NOS wall, posterior, NOS M-8014/3 Phenotype, large cell carcinoma with rhabdoid M-8700/3 Pheochromoblastoma (C74.1) M-8700/0 Pheochromocytoma, NOS (C74.1) M-8700/3 Pheochromocytoma, malignant (C74.1) 211 Alphabetic Index M-9360/1 Pinealoma (C75.3) M-9362/3 Pineoblastoma (C75.3) M-9362/3 Pineoblastoma-pineocytoma, mixed (C75.3) M-9361/1 Pineocytoma (C75.3) M-9362/3 Pineocytoma-pineoblastoma, mixed (C75.3) Phyllodes Cystosarcoma M-9020/1 NOS (C50._) M-9020/0 benign (C50._) [obs] M-9020/3 malignant (C50._) M-9020/1 M-9020/0 M-9020/1 M-9020/3 C70.9 C70.0 C70.1 Tumor NOS (C50._) benign (C50._) borderline (C50._) malignant (C50._) Pinkus tumor type, fibroepithelial basal cell carcinoma M-8093/3 type, fibroepithelioma M-8093/3 M-8093/3 Pia mater NOS cranial spinal C44.2 C12.9 C12.9 Pinna Piriform fossa Piriform sinus M-8372/0 M-8372/0 M-8090/3 M-8833/3 Pigmented adenoma (C74.0) adrenal cortical adenoma (C74.0) basal cell carcinoma (C44._) dermatofibrosarcoma protuberans (C44._) C75.1 C75.1 C75.1 Pituitary NOS fossa gland Nevus NOS (C44._) giant, NOS (C44._) giant, malignant melanoma in (C44._) C58.9 M-8720/0 M-8761/1 M-8761/3 M-8640/1 Pick tubular adenoma M-9560/0 M-8770/0 M--------- M-8272/0 Pituitary adenoma, NOS (C75.1) M-8272/3 Pituitary carcinoma, NOS (C75.1) M-9104/1 Placental site trophoblastic tumor (C58.9) schwannoma spindle cell nevus of Reed (C44._) villonodular synovitis (see SNOMED) M--------- Pilar cyst (see SNOMED) M-8103/0 Pilar tumor (C44._) C09.1 C09.1 Pillar, faucial Pillar, tonsillar M-9421/1 Pilocytic astrocytoma (C71._) In North America, report as 9421/3 M-9421/1 Piloid astrocytoma (C71._) In North America, report as 9421/3 M-8110/0 Pilomatricoma, NOS M-8110/3 Pilomatricoma, malignant (C44._) M-8110/3 Pilomatrix carcinoma (C44._) M-8110/0 Pilomatrixoma, NOS (C44._) M-8110/3 Pilomatrixoma, malignant (C44._) M-8148/2 PIN III (C61.9) M-9340/0 Pindborg tumor (C41._) C75.3 Placenta C49.2 C49.2 C44.7 Plantar aponeurosis fascia skin M---------M-9733/3 M-9732/3 M---------M-9731/3 Plasma cell granuloma (see SNOMED) leukemia (C42.1) myeloma (C42.1) pseudotumor (see SNOMED) tumor M-9733/3 Plasmacytic leukemia (C42.1) M-9671/3 Plasmacytic lymphoma [obs] Plasmacytoma NOS extramedullary (not occurring in bone) M-9731/3 of bone (C40._, C41._) M-9731/3 solitary M-9731/3 M-9734/3 M-8142/3 Plastica, linitis (C16._) Pineal gland M-8940/0 M-8941/3 M-8022/3 M-8802/3 M-8893/0 M-8854/0 M-8854/3 M-8901/3 Pineal tumor mixed (C75.3) parenchymal, intermediate differentiation (C75.3) M-9362/3 transitional (C75.3) M-9362/3 M-9362/3 212 Pleomorphic adenoma adenoma, carcinoma in (C07._, C08._) carcinoma cell sarcoma leiomyoma lipoma liposarcoma rhabdomyosarcoma, NOS Alphabetic Index Pleomorphic, continued rhabdomyosarcoma, adult type rhabdomyosarcoma, embryonal type, hepatocellular carcinoma (C22.0) M-9424/3 xanthoastrocytoma (C71._) M-8901/3 M-8910/3 M-8175/3 C38.4 C38.4 C38.4 M--------M-8210/3 M-8210/2 M-8210/3 M-8210/2 Pleura NOS parietal visceral M-8210/0 M-8210/3 M-8210/2 M-8210/3 M-8210/2 M-8213/0 M-8973/3 Pleuropulmonary blastoma M-8835/1 M-9131/0 M-8890/0 M-9550/0 M-9550/0 M-9560/0 Plexiform fibrohistiocytic tumor hemangioma leiomyoma neurofibroma neuroma schwannoma C47.1 C47.0 C71.5 C47.5 C47.5 Plexus brachial cervical choroid lumbosacral sacral C75.8 Pluriglandular M-9473/3 M-9473/3 M-8972/3 M-8254/3 M-9423/3 PNET, NOS PNET, supratentorial Pneumoblastoma (C34._) Pneumocyte, type II and goblet cell type bronchiolo-alveolar carcinoma (C34._) Pneumocyte, type II, bronchiolo-alveolar carcinoma (C34._) Polar spongioblastoma (C71._) Polar spongioblastoma, primitive (C71._) [obs] Polare, spongioblastoma (C71._) C71.1 C71.4 Pole, frontal Pole, occipital M-9950/3 M-9950/3 M--------M-9950/3 Polycythemia proliferative rubra vera secondary (see SNOMED) vera M-8252/3 M-9423/3 M-9423/3 M-8210/2 M--------M--------M--------M-8213/0 M--------M--------M--------M--------M--------M-8210/0 M-8210/3 M-8210/2 M-8932/0 Polyp NOS (see SNOMED) NOS, adenocarcinoma in NOS, adenocarcinoma in situ in NOS, carcinoma in NOS, carcinoma in situ in Adenomatous NOS adenocarcinoma in adenocarcinoma in situ carcinoma in carcinoma in situ in and hyperplastic, mixed (C18._) carcinoma in situ in, NOS fibroepithelial (see SNOMED) fibrous (see SNOMED) hyperplastic (see SNOMED) hyperplastic and adenomatous polyp, mixed (C18._) inflammatory (see SNOMED) juvenile (see SNOMED) lymphoid, NOS (see SNOMED) lymphoid, benign (see SNOMED) Peutz-Jeghers (see SNOMED) Polypoid adenoma adenoma, adenocarcinoma in adenoma, adenocarcinoma in situ in atypical adenomyoma Polyposis adenomatous, coli (C18._) adenomatous, coli, adenocarcinoma in (C18._) M-8220/0 coli, familial (C18._) M-9673/3 lymphomatous, malignant (includes all variants: blastic, pleomorphic, small cell) M-8221/0 multiple M-8220/0 M-8220/3 M-8221/0 Polyps, adenomatous, multiple M-8221/3 Polyps, adenomatous, multiple, adenocarcinoma in M-9071/3 Polyvesicular vitelline tumor C71.7 Pons M-------/-3 Poorly differentiated (see grading code, page 34) M-8631/3 Poorly differentiated Sertoli-Leydig cell tumor M-8634/3 Poorly differentiated Sertoli-Leydig cell tumor, with heterologous elements Polyembryoma Polyembryonal type embryonal carcinoma Polygonal cell carcinoma Polymorphic reticulosis [obs] Polymorphous low grade adenocarcinoma (C50._) M-9753/1 Poly-ostotic Langerhans cell histiocytosis M-9072/3 M-9072/3 M-8034/3 M-9719/3 M-8525/3 213 C77.4 Popliteal lymph node C76.5 C44.7 C49.2 Popliteal space NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) Alphabetic Index C49.2 C47.2 C49.2 C49.2 C49.2 C47.2 C44.7 C49.2 C49.2 C49.2 C49.2 M-8583/3 Predominantly cortical, thymoma, malignant (C37.9) M---------- Pregnancy luteoma (see SNOMED) Popliteal space, continued adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue tendon tendon sheath C77.0 M-9989/3 Preleukemia [obs] M-9989/3 Preleukemic syndrome (C42.1) [obs] M-9836/3 Pre-pre-B ALL (see also M-9728/3) C60.0 C16.4 C76.3 C77.5 M-8409/3 Porocarcinoma (C44._) M-8409/0 Poroma, eccrine (C44._) M-8409/3 Poroma, eccrine, malignant C77.2 C77.2 Porta hepatis lymph node Portal lymph node M-------- Portwine nevus (see SNOMED) C13.0 Postcricoid region C71.9 C11.3 C38.2 C32.1 C01.9 C01.9 Posterior cranial fossa margin of nasal septum mediastinum surface of epiglottis third of tongue tongue, NOS C67.4 C13.2 C10.3 C11.1 C10.3 C14.0 C16.8 C77.0 Pretracheal lymph node Primary amyloidosis cutaneous CD30+ T-cell lymphoproliferative disorder (C44._) M-8247/3 cutaneous neuroendocrine carcinoma (C44._) M-9270/3 intraosseous carcinoma (C41._) M-8461/3 serous papillary carcinoma of peritoneum (C48.1) M-9769/1 M-9718/3 M-------/3 Primary site, malignant (see Behavior code, page 31) Posterior wall bladder hypopharynx mesopharynx nasopharynx oropharynx pharynx, NOS stomach, NOS (not classifiable to C16.1 to C16.4) C80.9 Primary site unknown Primitive neuroectodermal tumor, NOS neuroectodermal tumor, central, NOS (C71._) M-9364/3 neuroectodermal tumor, peripheral, NOS M-9423/3 polar spongioblastoma (C71._) [obs] M-9473/3 M-9473/3 Pouch Douglas Rathke rectouterine M-9350/1 Pouch, Rathke, tumor (C75.1) M-9364/3 PPNET C77.0 Prepuce Prepylorus Presacral region, NOS Presymphysial lymph node M-9837/3 Pre-T ALL (see also M-9729/3) M-8936/1 Potential, uncertain malignant, gastrointestinal stromal tumor M-8897/1 Potential, uncertain malignant, smooth muscle tumor C48.1 C75.1 C48.1 Prelaryngeal lymph node Preauricular lymph node M-9836/3 Pre-B ALL (see also M-9728/3) M-8741/2 Precancerous melanosis, NOS (C44._) M-8741/3 Precancerous melanosis, malignant melanoma in (C44._) M-8583/1 Predominantly cortical, thymoma, NOS (C37.9) M---------M-9836/3 M-9837/3 M-8141/3 M-9363/0 M-9754/3 M-8271/0 Primordial cyst (see SNOMED) Pro-B ALL (see also M-9728/3) Pro-T ALL (see also M-9729/3) Productive fibrosis, carcinoma with Progonoma, melanotic Progressive histiocytosis X, acute Prolactinoma (C75.1) M-9000/1 M-8444/1 M-8442/1 M-8103/0 M-8103/0 Proliferating Brenner tumor (C56.9) clear cell tumor, atypical (C56.9) serous tumor, atypical (C56.9) trichilemmal cyst trichilemmal tumor Proliferative dermal lesion in congenital nevus (C44._) M-8380/1 endometrioid tumor, atypical M-8472/1 mucinous tumor, atypical (C56.9) M-8762/1 214 Alphabetic Index Proliferative, continued papillary serous tumor, atypical (C56.9) M-9950/3 polycythemia M-8462/1 C61.9 C61.9 Prostate, NOS Prostate gland M-8148/2 Prostatic intraepithelial neoplasia, grade III (C61.9) C68.0 C49.0 C47.0 C49.0 C49.0 C47.0 C49.0 Pterygoid fossa NOS autonomic nervous system connective tissue fibrous tissue peripheral nerve soft tissue C41.4 C51.9 Pubic bone Pudendum C34.9 C77.1 C77.1 Pulmonary NOS lymph node, NOS lymph node, hilar Prostatic utricle M-9410/3 Protoplasmic astrocytoma (C71._) M-8832/3 Protuberans, dermatofibrosarcoma, NOS (C44._) M-8833/3 Protuberans, dermatofibrosarcoma, pigmented (C44._) M-8250/1 Pulmonary adenomatosis (C34._) M-8972/3 Pulmonary blastoma (C34._) C15.3 Proximal third of esophagus C71.0 Putamen M-9533/0 M-9540/3 M-9560/0 Psammomatous meningioma (C70._) MPNST, melanotic schwannoma C16.3 C16.4 C77.2 Pyloric antrum canal lymph node C16.4 Pylorus M------- Pyogenic granuloma (see SNOMED) C71.7 C12.9 C12.9 Pyramid Pyriform fossa Pyriform sinus Pseudoepitheliomatous hyperplasia (see SNOMED) M-8075/3 Pseudoglandular squamous cell carcinoma M--------- Pseudolymphoma (see SNOMED) M--------- Pseudomucinous M-8470/3 adenocarcinoma (C56.9) M-8470/3 cystadenocarcinoma, NOS (C56.9) M-8471/3 cystadenocarcinoma, papillary (C56.9) M-8470/0 M-8472/1 M-8471/0 M-8473/1 Cystadenoma NOS (C56.9) borderline malignancy (C56.9) papillary, NOS (C56.9) papillary, borderline malignancy (C56.9) Q C49.2 M-8076/2 Questionable stromal invasion, epidermoid carcinoma in situ with M-8076/2 Questionable stromal invasion, squamous cell carcinoma in situ with M-8080/2 Queyrat erythroplasia (C60._) M-8480/6 Pseudomyxoma peritonei M-8480/3 Pseudomyxoma peritonei with unknown primary site (C80.9) M-8452/3 Pseudopapillary carcinoma, solid (C25._) M-8452/1 Pseudopapillary tumor, solid (C25._) M--------- Pseudopolyp, NOS (see SNOMED) M--------- Pseudosarcoma (see SNOMED) R Pseudosarcomatous M-8033/3 carcinoma M--------fasciitis (see SNOMED) M--------fibromatosis (see SNOMED) M--------M--------M--------- Pseudotumor NOS (see SNOMED) inflammatory (see SNOMED) plasma cell (see SNOMED) C49.4 Psoas muscle Quadriceps femoris muscle M-9123/0 Racemose hemangioma C49.1 C47.1 Radial artery Radial nerve M--------- Radicular cyst (see SNOMED) C40.0 Radius M-9983/3 RAEB (C42.1) M-9983/3 RAEB I (C42.1) 215 Alphabetic Index M-9983/3 RAEB II (C42.1) M-9984/3 RAEB-T (C42.1) M-9982/3 RARS (C42.1) C75.1 M-8312/3 Rathke pouch M-8312/3 M-8317/3 M-8316/3 M-8260/3 M-8318/3 M-8318/3 M-9350/1 Rathke pouch tumor (C75.1) M-9540/1 Recklinghausen disease (except of bone) M--------- Recklinghausen disease of bone (see SNOMED) C20.9 Rectal ampulla C19.9 C19.9 C19.9 Rectosigmoid NOS colon junction C48.1 C76.3 C76.3 C20.9 C19.9 C49.4 Rectouterine pouch Rectovaginal septum Rectovesical septum Rectum, NOS Rectum and colon Rectus abdominis muscle Refractory anemia (C42.1) NOS with excess blasts (RAEB) with excess blasts in transformation (RAEB-T) [obs] M-9982/3 with ringed sideroblasts (RARS) M-9982/3 with sideroblasts M-9980/3 without sideroblasts M-9985/3 Refractory cytopenia with multilineage dysplasia M-9514/1 Regressed, spontaneously, retinoblastoma (C69.2) M-8723/3 Regressing malignant melanoma (C44._) M-8723/0 Regressing nevus (C44._) C64.9 C49.4 C65.9 C65.9 C65.9 Renal NOS artery calyces calyx pelvis C39.9 C39.0 Respiratory tract, NOS Respiratory tract, upper, NOS M--------M-8671/0 M--------- Rest embryonal, NOS (see SNOMED) tumor, adrenal Walthard (see SNOMED) C62.0 C42.3 Retained testis (site of neoplasm) Reticuloendothelial system, NOS M-9940/3 Reticuloendotheliosis, leukemic M-9754/3 Reticuloendotheliosis, nonlipid [obs] M--------- Reticulohistiocytic granuloma (see SNOMED) M-8831/0 Reticulohistiocytoma M-9980/3 M-9983/3 M-9984/3 Reil Reil, Island of Reil organ of Carcinoma NOS (C64.9) chromophobe type (C64.9) cyst-associated (C64.9) papillary (C64.9) sarcomatoid (C64.9) spindle cell (C64.9) M-8361/0 Reninoma (C64.9) M-8966/0 Renomedullary fibroma (C64.9) M-8966/0 Renomedullary interstitial cell tumor (C64.9) M-8041/3 Reserve cell carcinoma M-8770/0 Reed pigmented spindle cell nevus (C44._) C71.0 C71.0 C71.0 Renal cell adenocarcinoma (C64.9) M-9591/3 M-9591/3 Reticulosarcoma NOS [obs] diffuse [obs] M-9750/3 M-9719/3 M-9719/3 M-9700/3 M-9719/3 Reticulosis histiocytic medullary [obs] malignant, NOS [obs] malignant midline [obs] Pagetoid polymorphic [obs] M-9591/3 M-9591/3 M-8633/1 M-8634/1 Reticulum cell sarcoma, NOS [obs] Reticulum cell sarcoma, diffuse [obs] Retiform Sertoli-Leydig cell tumor Retiform Sertoli-Leydig cell tumor, with heterologous elements C69.2 Retina M-9363/0 Retinal anlage tumor Renal M-8317/3 carcinoma, chromophobe cell (C64.9) M-8319/3 carcinoma, collecting duct type (C64.9) M-8967/0 tumor, ossifying (C64.9) M-9510/3 M-9511/3 M-9513/3 M-9514/1 M-9512/3 Retinoblastoma NOS (C69.2) differentiated (C69.2) diffuse (C69.2) spontaneously regressed (C69.2) undifferentiated (C69.2) M-9510/0 Retinocytoma (C69.2) 216 Alphabetic Index C69.6 C48.0 Retrobulbar tissue Retrocecal tissue C06.2 C06.2 C06.2 Retromolar area triangle trigone M-8822/1 Retroperitoneal fibromatosis (C48.0) C77.2 C48.0 C48.0 C77.0 C14.0 Retroperitoneal lymph node Retroperitoneal tissue Retroperitoneum Retropharyngeal lymph node Retropharynx M-9538/3 M-8014/3 M-8963/3 M-8963/3 M-8963/3 Rhabdoid meningioma (C70._) phenotype, large cell carcinoma with sarcoma tumor, NOS tumor, malignant C11.2 C77.4 Rosenmuller fossa Rosenmuller lymph node M-8041/3 M-8853/3 M-9185/3 M-8803/3 M-8806/3 Round cell carcinoma liposarcoma osteosarcoma (C40._, C41._) sarcoma tumor, desmoplastic small C57.2 Round ligament M-9950/3 Rubra vera, polycythemia M--------- Rugal hypertrophy, giant (see SNOMED) S M-9508/3 Rhabdoid/teratoid tumor, atypical (C71._) Rhabdomyoblastic differentiation malignant peripheral nerve sheath tumor with M-9561/3 malignant schwannoma with M-9561/3 MPNST with C69.5 Sac, lacrimal C72.0 C77.5 C47.5 C47.5 Sacral cord lymph node nerve plexus C76.3 C44.5 C49.5 C49.5 C47.5 C49.5 C49.5 C49.5 C49.5 C47.5 C49.5 C44.5 C49.5 C49.5 Sacrococcygeal region NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C41.4 Sacrum M-9561/3 M-8900/0 M-8904/0 M-8903/0 M-8905/0 M-8904/0 Rhabdomyoma NOS adult fetal genital (C51._, C52.9) glycogenic M-8900/3 M-8901/3 M-8920/3 M-8902/3 M-8910/3 M-8910/3 M-8902/3 M-8902/3 M-8901/3 M-8912/3 M-8921/3 Rhabdomyosarcoma NOS adult type alveolar alveolar and embryonal, mixed embryonal, NOS embryonal, pleomorphic mixed embryonal and alveolar mixed type pleomorphic, NOS spindle cell with ganglionic differentiation C08.9 C08.9 C06.9 M-8900/3 Rhabdosarcoma C71.0 C41.3 C18.2 Rhinencephalon Rib Right colon M-8940/0 Salivary gland type mixed tumor, NOS (C07._, C08._) M-8940/3 Salivary gland type mixed tumor, malignant (C07._, C08._) M--------- Salpingitis isthmica nodosa (see SNOMED) M-8090/3 Rodent ulcer (C44._) C05.9 C11.0 C01.9 Salivary gland NOS (excludes minor salivary gland, NOS C06.9; see coding guidelines, page 38 and note under C08) major, NOS minor, NOS (see coding guidelines, page 38 and note under C08) Roof of mouth Roof of nasopharynx Root of tongue M-9699/3 SALT lymphoma 217 Alphabetic Index C25.3 M--------M-8800/3 M-9581/3 M-9330/3 M-9471/3 M-8910/3 M-8910/3 M-9480/3 M-9471/3 M-9044/3 M-8964/3 M-9044/3 Santorini duct Sarcoma, continued myeloid (see also M-9861/3) neurogenic [obs] odontogenic (C41._) osteoblastic (C40._, C41._) osteogenic, NOS (C40._, C41._) periosteal, NOS (C40._, C41._) pleomorphic cell reticulum cell, NOS [obs] reticulum cell, diffuse [obs] rhabdoid round cell small cell soft tissue spindle cell Sarcoma NOS alveolar soft part ameloblastic (C41._) arachnoidal cerebellar, circumscribed (C71.6) [obs] botryoid botryoides cerebellar, NOS (C71.6) [obs] circumscribed arachnoidal cerebellar (C71.6) [obs] M-9930/3 M-9540/3 M-9270/3 M-9180/3 M-9180/3 M-8812/3 M-8802/3 M-9591/3 M-9591/3 M-8963/3 M-8803/3 M-8803/3 M-8800/3 M-8801/3 Clear cell NOS (except of kidney M-8964/3) of kidney (C64.9) of tendons and aponeuroses (C49._) M-8935/3 M-8930/3 M-8930/3 M-8931/3 M-8936/3 Stromal NOS endometrial, NOS (C54.1) endometrial, high grade (C54.1) endometrial, low grade (C54.1) gastrointestinal M-9040/3 M-9043/3 M-9042/3 M-9041/3 M-9041/3 Synovial NOS biphasic epithelioid cell monophasic fibrous spindle cell M-8805/3 undifferentiated Sarcoid granuloma (see SNOMED) M-9757/3 M-9758/3 M-9757/3 Dendritic cell NOS follicular interdigitating M-8991/3 embryonal M-8930/3 M-8930/3 M-8930/3 M-8931/3 Endometrial NOS (C54.1) stromal, NOS (C54.1) stromal, high grade (C54.1) stromal, low grade (C54.1) M-8804/3 M-8804/3 M-9260/3 M-9758/3 M-8936/3 M-8802/3 M-9250/3 M-8710/3 M-9930/3 M-9130/3 M-9140/3 M-9755/3 M-9662/3 M-9684/3 M-9757/3 M-9757/3 M-9140/3 M-9124/3 M-9756/3 M-9530/3 M-9170/3 M-9740/3 M-9530/3 M-9530/3 M-8990/3 M-9441/3 M-9140/3 epithelioid epithelioid cell Ewing (C40._, C41._) follicular dendritic cell gastrointestinal stromal giant cell (except of bone M-9250/3) giant cell, bone (C40._, C41._) glomoid granulocytic hemangioendothelial hemorrhagic, multiple histiocytic Hodgkin [obs] immunoblastic [obs] interdigitating cell interdigitating dendritic cell Kaposi Kupffer cell (C22.0) Langerhans cell leptomeningeal (C70._) lymphangioendothelial (C70._) mast cell meningeal (C70._) meningothelial (C70._) mesenchymal, mixed monstrocellular [obs] (C71._) multiple hemorrhagic M-8033/3 M-8173/3 M-8318/3 M-8074/3 M-8620/3 M-9051/3 M-8318/3 M-8631/3 M-8074/3 M-8122/3 Sarcomatoid carcinoma carcinoma, hepatocellular (C22.0) carcinoma, renal cell (C64.9) carcinoma, squamous cell granulosa cell tumor (C56.9) mesothelioma renal cell carcinoma (C64.9) Sertoli-Leydig cell tumor squamous cell carcinoma transitional cell carcinoma M-8800/9 Sarcomatosis, NOS M-9539/3 Sarcomatosis, meningeal (C70._) M-9442/3 Sarcomatous component, glioblastoma with (C71._) 218 C77.0 Scalene lymph node C44.4 C44.4 C49.0 C49.0 C47.0 C49.0 C49.0 C49.0 C49.0 C47.0 C49.0 Scalp NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle Alphabetic Index C44.4 C49.0 C49.0 Scalp, continued skin soft tissue subcutaneous tissue C40.0 Scapula C76.1 C44.5 C49.3 C49.3 C47.3 C49.3 C49.3 C49.3 C47.3 C44.5 C49.3 C49.3 Scapular region NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue M--------- Scar, hyperplastic (see SNOMED) M-8082/3 Schmincke tumor (C11._) M-9560/0 M-9560/0 M-9560/0 M-9560/0 M-9560/3 M-9561/3 M-9560/0 M-9560/0 M-9560/0 M-9560/0 M-9561/3 C47.2 Sclerosing, continued carcinoma, nonencapsulated (C73.9) carcinoma, papillary, diffuse (C73.9) hemangioma (C44._) hepatic carcinoma (C22.0) liposarcoma papillary carcinoma, diffuse (C73.9) stromal tumor (C56.9) sweat duct carcinoma (C44._) tumor, nonencapsulated (C73.9) tumor, stromal (C56.9) C62.1 C63.2 C63.2 Scrotal testis Scrotum, NOS Scrotum, skin M-8410/3 M-8410/0 M-8410/3 M--------M-8410/0 Sebaceous adenocarcinoma (C44._) adenoma (C44._) carcinoma (C44._) cyst (see SNOMED) epithelioma (C44._) M--------- Seborrheic keratosis (see SNOMED) M--------- Seborrheic verruca (see SNOMED) M-------/6 Secondary site (see behavior code, page 31) Schneiderian M-8121/3 carcinoma (C30.0, C31._) M-8121/0 M-8121/1 M-8121/1 M-8350/3 M-8350/3 M-8832/0 M-8172/3 M-8851/3 M-8350/3 M-8602/0 M-8407/3 M-8350/3 M-8602/0 Papilloma NOS (C30.0, C31._) inverted (C30.0, C31._) oncocytic (C30.0, C31._) Schwannoma NOS ancient cellular degenerated malignant, NOS [obs] malignant, with rhabdomyoblastic differentiation melanotic pigmented plexiform psammomatous with rhabdomyoblastic differentiation, malignant M-8010/6 M-8000/6 M--------M-8000/6 M-9084/3 Secondary carcinoma neoplasm polycythemia (see SNOMED) tumor tumor, dermoid cyst with (C56.9) M-8502/3 M-9530/0 M-8382/3 Secretory carcinoma, breast (C50._) meningioma (C70._) variant, endometrioid adenocarcinoma C75.1 Sella turcica M-9582/0 Sellar region granular cell tumor (C75.1) C40.2 C63.7 Semilunar cartilage Seminal vesicle Seminoma NOS (C62._) and teratoma, mixed anaplastic (C62._) spermatocytic (C62._) with high mitotic index (C62._) Senile keratosis (see SNOMED) Sciatic nerve M-8141/3 M-8141/3 M-8172/3 Scirrhous adenocarcinoma carcinoma carcinoma, hepatocellular (C22.0) M-9061/3 M-9085/3 M-9062/3 M-9063/3 M-9062/3 C69.4 Sclera M-------- Sclerosing adenocarcinoma, nonencapsulated (C73.9) M--------adenosis (see SNOMED) M-8092/3 basal cell carcinoma, infiltrating (C44._) M-8350/3 C30.0 C11.3 C76.3 C76.3 219 Septum nasal, NOS (excludes posterior margin of nasal septum C11.3) nasal, posterior margin rectovaginal rectovesical Alphabetic Index C57.9 C57.9 Septum, continued urethrovaginal vesicovaginal M-8640/1 M-8642/1 M-8641/0 M-8641/0 M-8241/3 Serotonin producing carcinoid M-9014/3 M-8441/3 M-8460/3 Serous adenocarcinofibroma adenocarcinoma, NOS (C56.9) adenocarcinoma, papillary (C56.9) M-9014/0 M-9014/1 M-9014/3 Adenofibroma NOS borderline malignancy malignant M-8441/0 M-8441/3 M-8460/3 M-9014/3 M-8441/3 M-8460/3 adenoma, microcystic carcinoma (C56.9) carcinoma, micropapillary (C56.9) cystadenocarcinofibroma cystadenocarcinoma, NOS (C56.9) cystadenocarcinoma, papillary (C56.9) M-9014/0 M-9014/1 M-9014/3 Cystadenofibroma NOS borderline malignancy malignant M-8441/0 M-8442/1 M-8460/0 M-8462/1 M-8441/0 M-8441/0 M-8461/3 M-8462/1 M-8461/3 M-8463/1 M-8461/0 M-8442/1 M-8442/1 M-8462/1 M-8462/1 M-8631/1 M-8631/1 M-8634/1 M-8631/3 M-8634/3 M-8633/1 M-8634/1 M-8631/3 M-8631/0 Sertoli cell, continued Tumor NOS large cell calcifying lipid-rich (C56.9) with lipid storage (C56.9) Sertoli-Leydig cell tumor NOS intermediate differentiation intermediate differentiation, with heterologous elements poorly differentiated poorly differentiated, with heterologous elements retiform retiform, with heterologous elements sarcomatoid well differentiated M-8588/3 SETTLE M-8077/2 Severe dysplasia, CIN III with (C53._) Sex cord elements, stromal tumor with minor (C56.9) M-8590/1 tumor, NOS M-8623/1 tumor with annular tubules (C56.9) M-8593/1 Cystadenoma NOS (C56.9) borderline malignancy (C56.9) papillary, NOS (C56.9) papillary, borderline malignancy (C56.9) M-8590/1 M-8591/1 M-8592/1 Sex cord-gonadal stromal tumor NOS incompletely differentiated mixed forms M-9701/3 Sezary disease M-9701/3 Sezary syndrome cystoma (C56.9) microcystic adenoma papillary carcinoma, primary, peritoneum (C48.1) papillary cystic tumor of borderline malignancy (C56.9) C76.4 C44.6 C49.1 C49.1 C47.1 C40.0 C49.1 C49.1 C49.1 C40.0 C40.0 C49.1 C47.1 C49.1 C44.6 C49.1 C49.1 Surface papillary carcinoma (C56.9) papillary tumor of borderline malignancy (C56.9) papilloma (C56.9) Tumor NOS, of low malignant potential (C56.9) atypical proliferating (C56.9) papillary, atypical proliferative (C56.9) papillary, of low malignant potential (C56.9) Shoulder NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system bone connective tissue fatty tissue fibrous tissue girdle joint muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue M-8974/1 Sialoblastoma M-8213/0 Serrated adenoma (C18._) M-9982/3 M-9982/3 M-9980/3 Sertoli cell M-8640/1 adenoma M-8640/3 carcinoma (C62._) 220 Sideroblasts refractory anemia with (C42.1) refractory anemia with ringed (C42.1) refractory anemia without (C42.1) Alphabetic Index C18.7 C18.7 C18.7 Sigmoid NOS colon flexure of colon M-8490/3 M-8490/3 M-8490/6 Signet ring cell adenocarcinoma carcinoma carcinoma, metastatic C49.3 C49.1 C49.2 C49.6 C44.9 M-8231/3 Simplex, carcinoma M-9131/0 Simplex, hemangioma M-8121/0 M-8121/0 M-8121/0 Sinonasal papilloma NOS (C30.0, C31._) exophytic (C30.0, C31._) fungiform (C30.0, C31._) C31.9 C31.9 C31.1 C31.2 C31.0 C31.9 C12.9 C31.3 Sinus accessory, NOS accessory, nasal ethmoid frontal maxillary paranasal pyriform sphenoid C44.5 C44.5 C44.3 C44.7 C44.6 C44.5 C44.6 C44.2 C44.2 C44.2 C44.2 C44.2 C44.2 C44.5 C44.5 C44.5 C44.3 C44.5 C44.7 C44.1 C44.1 C44.1 C44.4 C44.3 C44.3 C44.5 C44.5 C44.3 C44.3 C44.2 C44.2 C44.2 C44.2 C44.2 C44.2 C44.6 C44.2 C44.3 C44.1 C44.1 C44.1 C44.3 C44.6 C44.5 C44.7 C44.6 C44.3 C44.5 C44.5 C44.6 C44.4 C44.7 C44.2 Sinus histiocytosis with massive lymphadenopathy (see SNOMED) M-9071/3 Sinus tumor, endodermal M------- Site C76.2 C71.9 C76.1 C80.9 intra-abdominal, NOS intracranial intrathoracic, NOS primary, unknown C41.9 Skeletal bone C49.9 C49.4 C49.1 C49.6 C49.5 C49.2 C49.3 C49.0 C49.1 C49.6 C49.2 C49.1 C49.1 C49.0 C49.2 C49.0 C49.5 C49.5 C49.0 C49.1 C49.2 C49.3 Skeletal muscle NOS abdominal wall arm back buttock calf chest wall face finger flank foot forearm hand head leg neck perineum sacrococcygeal region scalp shoulder thigh thoracic wall 221 Skeletal muscle, continued thorax thumb toe trunk, NOS Skin NOS (excludes skin of vulva C51._, skin of penis C60.9 and skin of scrotum C63.2) abdomen abdominal wall ala nasi ankle antecubital space anus arm auditory canal, NOS auditory canal, external auditory meatus, external auricle auricular canal, NOS auricular canal, external axilla back breast brow buttock calf canthus, NOS canthus, inner canthus, outer cervical region cheek, NOS cheek, external chest chest wall chin columnella concha ear, NOS ear canal ear, external ear lobule earlobe elbow external ear eyebrow eyelid, NOS eyelid, lower eyelid, upper face finger flank foot forearm forehead gluteal region groin hand head, NOS heel helix Alphabetic Index C44.7 C44.5 C44.5 C44.1 C44.3 C44.7 C51.0 C44.7 C44.1 C44.1 C44.1 C44.7 C44.6 C44.0 C44.0 C44.0 C44.2 C44.4 C44.3 C44.3 C44.1 C44.6 C44.6 C44.1 C60.9 C44.5 C44.5 C44.2 C44.7 C44.7 C44.5 C44.4 C44.5 C63.2 C44.6 C44.7 C44.4 C44.3 C44.7 C44.5 C44.5 C44.6 C44.7 C44.2 C44.5 C44.5 C51.9 C44.6 Skin, continued hip infraclavicular region inguinal region inner canthus jaw knee labia majora leg lid, NOS lid, lower lid, upper limb, lower limb, upper lip, NOS lip, lower lip, upper lobule, ear neck nose nose, external outer canthus palm palmar palpebra penis perianal perineum pinna plantar popliteal space sacrococcygeal region scalp scapular region scrotum shoulder sole, foot supraclavicular region temple thigh thoracic wall thorax thumb toe tragus trunk umbilicus vulva wrist Small congenital nevus (C44._) intestinal disease, immunoproliferative (C17._) M-8806/3 round cell tumor, desmoplastic M-8761/0 M-9764/3 M-8041/3 M-8045/3 M-8073/3 M-8043/3 M-8044/3 M-8045/3 M-8041/3 M-8073/3 M-9185/3 M-8803/3 M-8002/3 osteosarcoma (C40._, C41._) sarcoma type, malignant tumor M-8045/3 Small cell-adenocarcinoma, combined (C34._) M-8045/3 Small cell-large cell carcinoma, combined (C34._) M-8045/3 Small cell-squamous cell carcinoma, combined (C34._) C17.9 C17.0 C17.2 C17.1 C17.3 C17.9 Small intestine NOS duodenum ileum (excludes ileocecal valve C18.0) jejunum Meckel diverticulum (site of neoplasm) small bowel, NOS M-9764/3 Small intestinal immunoproliferative disease (C17._) M-8897/1 Smooth muscle tumor, NOS M-8897/1 Smooth muscle tumor, uncertain malignant potential C03.9 C05.1 C05.8 C11.3 Skin appendage adenoma (C44._) M-8390/0 M-8390/3 carcinoma (C44._) M-8390/0 tumor, benign (C44._) C41.0 C41.0 C17.9 Small cell Carcinoma NOS combined epidermoid, nonkeratinizing fusiform cell intermediate cell mixed neuroendocrine squamous cell, nonkeratinizing Socket, tooth Soft palate NOS (excludes nasopharyngeal surface C11.3) and hard palate, junction nasopharyngeal surface M-9581/3 Soft part sarcoma, alveolar Skull, NOS Skull, bone Small bowel, NOS M-9251/1 M-9251/3 M-9044/3 222 Soft parts giant cell tumor, NOS giant cell tumor, malignant melanoma, malignant (C49._) Alphabetic Index C49.9 C49.4 C49.4 C49.2 C49.1 C49.1 C49.3 C49.6 C49.5 C49.2 C49.0 C49.0 C49.3 C49.3 C49.0 C49.1 C49.0 C49.1 C49.6 C49.2 C49.1 C49.0 C49.5 C49.5 C49.1 C49.0 C49.2 C49.2 C49.3 C49.5 C49.2 C49.2 C49.0 C69.6 C49.5 C49.2 C49.0 C49.5 C49.0 C49.3 C49.1 C49.0 C49.0 C49.2 C49.3 C49.1 C49.2 C49.6 C49.4 C49.1 M-9571/0 M-8800/3 M-8850/1 M-8800/0 M-8800/3 C44.7 Soft tissue NOS abdomen abdominal wall ankle antecubital space arm axilla back buttock calf cervical region cheek chest chest wall chin elbow face finger flank foot forearm forehead gluteal region groin hand head heel hip infraclavicular region inguinal region knee leg neck orbit perineum popliteal space pterygoid fossa, NOS sacrococcygeal region scalp scapular region shoulder supraclavicular region temple thigh thoracic wall thumb toe trunk, NOS umbilicus wrist M-8230/3 M-8230/3 M-8452/3 M-8452/1 M-9080/1 M-8230/2 M-8230/2 Solid adenocarcinoma with mucin formation and cystic tumor (C25._) and papillary epithelial neoplasm (C25._) carcinoma, NOS carcinoma with mucin formation pseudopapillary carcinoma (C25._) pseudopapillary tumor (C25._) teratoma type, ductal carcinoma in situ (C50._) type, intraductal carcinoma M--------M-8815/0 M-8815/3 M-9731/3 M-9731/3 Solitary cyst (see SNOMED) fibrous tumor fibrous tumor, malignant myeloma plasmacytoma M-8156/1 M-8156/3 M-8156/1 M-8156/3 Somatostatin cell tumor, NOS Somatostatin cell tumor, malignant Somatostatinoma, NOS Somatostatinoma, malignant C63.1 Spermatic cord M-8230/3 M-8452/1 M-8452/1 M-9063/3 Spermatocytic seminoma (C62._) M-9063/3 Spermatocytoma (C62._) perineurioma sarcoma superficial, well differentiated liposarcoma tumor, benign tumor, malignant Sole of foot 223 C41.0 C31.3 C21.1 C24.0 Sphenoid bone Sphenoid sinus Sphincter, anal Sphincter of Oddi M--------M--------M--------- Spider angioma (see SNOMED) nevus (see SNOMED) vascular (see SNOMED) C72.5 C70.1 C41.2 C72.0 C70.1 C70.1 C47.9 C70.1 Spinal accessory nerve arachnoid column cord dura mater meninges nerve, NOS pia mater M-8770/3 M-8770/0 M-9130/1 Spindle cell and epithelioid melanoma, mixed and epithelioid nevus (C44._) angioendothelioma M-8032/3 M-8030/3 M-8318/3 Carcinoma NOS and giant cell carcinoma renal cell (C64.9) M-8074/3 M-9136/1 M-8857/0 epidermoid carcinoma hemangioendothelioma lipoma Alphabetic Index M-8772/3 M-8770/3 M-8773/3 M-8774/3 M-8572/3 M-8772/0 M-8770/0 M-8318/3 M-8912/3 M-8801/3 M-8074/3 M-9041/3 M-8581/1 M-8581/3 M-8122/3 M-8004/3 M-8173/3 Spindle cell, continued Melanoma NOS and epithelioid melanoma, mixed type A (C69._) type B (C69._) M--------M-9312/0 M-8052/0 M-8060/0 metaplasia, adenocarcinoma with nevus (C44._) nevus of Reed, pigmented (C44._) renal cell carcinoma (C64.9) rhabdomyosarcoma sarcoma squamous cell carcinoma synovial sarcoma thymoma, NOS (C37.9) thymoma, malignant (C37.9) transitional cell carcinoma type, malignant tumor variant, hepatocellular carcinoma (C22.0) C41.2 Spine M-8403/0 M-8403/0 M-8403/3 Spiradenoma NOS (C44._) eccrine (C44._) eccrine, malignant (C44._) Spleen C18.5 C77.2 C77.2 Splenic flexure of colon lymph node, NOS lymph node, hilar M--------- Sponge nevus, white (see SNOMED) M-9421/1 M-9440/3 M-9423/3 M-9423/3 M-9423/3 Spongioblastoma NOS (C71._) [obs] multiforme (C71._) polar (C71._) polare (C71._) primitive polar (C71._) [obs] Squamocolumnar junction, cervix M-8070/3 M-8077/2 M--------- Squamous carcinoma intraepithelial neoplasia, grade III keratosis, benign (see SNOMED) epithelioma metaplasia, adenocarcinoma with M-8052/0 M-8560/0 M-8053/0 Papilloma NOS and glandular papilloma, mixed inverted M-8081/2 M-8094/3 Squamous-basal cell carcinoma, mixed (C44._) M-8045/3 Squamous cell-small cell carcinoma, combined (C34._) M-9504/3 Spongioneuroblastoma M-9514/1 Spontaneously regressed retinoblastoma (C69.2) C53.8 M-8070/3 M-8570/3 M-8084/3 M-8070/2 M-8076/2 M-8770/0 Spitz nevus (C44._) C42.2 M-8070/2 M-8071/3 M-8071/3 M-8072/3 M-8070/6 M-8076/3 M-8072/3 M-8052/3 M-8052/2 M-8052/2 M-8075/3 M-8074/3 M-8073/3 M-8074/3 M-8051/3 M-8078/3 Squamous cell Carcinoma NOS acantholytic adenoid and adenocarcinoma, mixed basaloid Bowen type, intraepidermal (C44._) clear cell type in situ, NOS in situ with questionable stromal invasion intraepidermal, Bowen type (C44._) intraepithelial keratinizing, NOS large cell, keratinizing large cell, nonkeratinizing, NOS metastatic, NOS microinvasive nonkeratinizing, NOS papillary papillary, in situ papillary, non-invasive pseudoglandular sarcomatoid small cell, nonkeratinizing spindle cell verrucous with horn formation M-8070/3 M-8075/3 M-8075/3 M-8560/3 M-8083/3 M-8081/2 M-8588/3 Spindle epithelial tumor with thymus-like differentiation M-8588/3 Spindle epithelial tumor with thymus-like element M-9051/3 Spindled mesothelioma Squamous, continued metaplasia (see SNOMED) odontogenic tumor (C41._) papilloma papillomatosis M--------- Steatocystoma multiplex (see SNOMED) C71.7 Stem, brain M-9801/3 Stem cell leukemia C07.9 C49.0 C41.3 C41.3 224 Stensen duct Sternocleidomastoid muscle Sternocostal joint Sternum Alphabetic Index M-8670/0 Steroid cell tumor, NOS (C56.9) M-8670/3 Steroid cell tumor, malignant (C56.9) M-8936/1 C16.9 C16.8 C16.3 C16.3 C16.3 C16.2 C16.0 C16.0 C16.0 C16.2 C16.2 C16.0 C16.1 C16.1 C16.0 C16.6 C16.5 C16.8 C16.4 C16.3 C16.4 C16.4 Stomach NOS anterior wall, NOS (not classifiable to C16.1 to C16.4) antrum antrum, gastric antrum, pyloric body cardia, NOS cardia, gastric cardioesophageal junction corpus corpus, gastric esophagogastric junction fundus fundus, gastric gastroesophageal junction greater curvature, NOS (not classifiable to C16.1 to C16.4) lesser curvature, NOS (not classifiable to C16.1 to C16.4) posterior wall, NOS (not classifiable to C16.1 to C16.4) prepylorus pyloric antrum pyloric canal pylorus M-8590/1 M-8590/1 M-8602/0 M-8590/1 M-8591/1 M-8592/1 M-8590/1 M-8593/1 M-8931/3 Stromatosis, endometrial (C54.1) M-9090/0 M-9091/1 M-9090/3 C53.8 Stroma, endometrial Stromal endometriosis (C54.1) hyperplasia (see SNOMED) myosis, NOS (C54.1) myosis, endolymphatic (C54.1) nodule, endometrial (C54.1) M-8935/3 M-8930/3 M-8930/3 M-8931/3 M-8936/3 Sarcoma NOS endometrial, NOS (C54.1) endometrial, high grade (C54.1) endometrial, low grade (C54.1) gastrointestinal M-8935/1 M-8935/0 M-8936/1 M-8936/0 M-8936/3 Tumor NOS benign gastrointestinal, NOS gastrointestinal, benign gastrointestinal, malignant Stump, cervical M-8506/0 Subareolar duct papillomatosis (C50.0) M-8345/3 Stroma, medullary carcinoma with amyloid (C73.9) M-8512/3 Stroma, medullary carcinoma with lymphoid M-8931/3 M---------M-8931/3 M-8931/3 M-8930/0 Struma ovarii NOS (C56.9) and carcinoid (C56.9) malignant (C56.9) M-9091/1 Strumal carcinoid (C56.9) M-8641/0 Storage, lipid, Sertoli cell tumor with M-8641/0 Storage, lipid, tubular androblastoma with M-------- Strawberry nevus (see SNOMED) C54.1 Stromal, continued Tumor, continued gastrointestinal, uncertain malignant potential gonadal ovarian (C56.9) sclerosing (C56.9) sex cord-gonadal sex cord-gonadal, incompletely differentiated sex cord-gonadal, mixed forms testicular (C62._) with minor sex cord elements (C56.9) 225 C49.3 C77.3 Subclavian artery Subclavicular lymph node C49.9 C49.4 C49.4 C49.2 C49.1 C49.1 C49.3 C49.6 C49.5 C49.2 C49.0 C49.0 C49.3 C49.3 C49.0 C49.1 C49.0 C49.1 C49.6 C49.2 C49.1 C49.0 C49.5 C49.5 C49.1 C49.0 C49.2 C49.2 C49.3 C49.5 Subcutaneous tissue NOS abdomen abdominal wall ankle antecubital space arm axilla back buttock calf cervical region cheek chest chest wall chin elbow face finger flank foot forearm forehead gluteal region groin hand head heel hip infraclavicular region inguinal region Alphabetic Index C49.2 C49.2 C49.0 C49.5 C49.2 C49.5 C49.0 C49.3 C49.1 C49.0 C49.0 C49.2 C49.3 C49.3 C49.1 C49.2 C49.6 C49.4 C49.1 Subcutaneous tissue, continued knee leg neck perineum popliteal space sacrococcygeal region scalp scapular region shoulder supraclavicular region temple thigh thoracic wall thorax thumb toe trunk, NOS umbilicus wrist M-9383/1 M-9384/1 M-9383/1 Subependymal astrocytoma, NOS (C71._) astrocytoma, giant cell (C71._) glioma (C71._) M-9383/1 Subependymoma (C71._) M-9383/1 Subependymoma-ependymoma, mixed (C71._) M-8832/0 Subepidermal nodular fibrosis (C44._) C32.2 C77.4 Subglottis Subinguinal lymph node C08.1 C08.1 C77.0 Sublingual gland gland duct lymph node C08.0 C77.0 Submandibular gland Submandibular lymph node C08.0 C08.0 C77.0 Submaxillary gland gland duct lymph node C77.0 C77.3 Submental lymph node Subscapular lymph node C06.1 C06.1 C06.1 Sulcus alveolar buccal labial C77.2 C49.3 C11.0 Superior mesenteric lymph node vena cava wall of nasopharynx C77.0 Supraclavicular lymph node C76.0 C44.4 C49.0 C49.0 C47.0 C49.0 C49.0 C49.0 C77.0 C47.0 C44.4 C49.0 C49.0 Supraclavicular region NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue lymph node peripheral nerve skin soft tissue subcutaneous tissue C32.1 C74.9 C71.9 C71.0 Supraglottis Suprarenal gland Suprasellar Supratentorial brain, NOS (see also brain) M-9473/3 Supratentorial PNET Surface osteosarcoma, high grade (C40._, C41._) M-8461/3 papillary carcinoma, serous (C56.9) M-8463/1 papillary tumor, serous surface, borderline malignancy (C56.9) M-8461/0 papilloma, serous (C56.9) M-9194/3 M-8407/3 Sweat duct carcinoma, sclerosing (C44._) M-8400/3 M-8400/0 M-8400/3 M-8400/1 M-8400/0 M-8400/3 C47.9 M-8850/1 M-8143/3 M-8743/3 M-8850/1 Tumor NOS (C44._) benign (C44._) malignant (C44._) Sympathetic nervous system, NOS M-8681/1 Sympathetic paraganglioma M-9500/3 Sympathicoblastoma C41.4 M-8091/3 Sweat gland adenocarcinoma (C44._) adenoma (C44._) carcinoma (C44._) Superficial basal cell carcinoma, multifocal (C44._) soft tissue, well differentiated liposarcoma spreading adenocarcinoma spreading melanoma (C44._) well differentated liposarcoma Symphysis pubis M-8893/0 Symplastic leiomyoma M-9531/0 Syncytial meningioma (C70._) Syndrome 5q deletion (5q–), with myelodysplastic syndrome M-9964/3 hypereosinophilic M-9986/3 226 Alphabetic Index M-9989/3 M-9895/3 M-9895/3 M-9986/3 M-9989/3 M-9701/3 Syndrome, continued Myelodysplastic NOS (C42.1) prior, acute myeloid leukemia with prior, acute myeloid leukemia without with 5q deletion (5q–) syndrome preleukemic (C42.1) [obs] Sezary C49.9 Synovia, NOS M--------M--------- Synovial chondromatosis (see SNOMED) Synovial osteochondromatosis (see SNOMED) M-9040/3 M-9043/3 M-9042/3 M-9041/3 M-9041/3 Synovial sarcoma NOS biphasic epithelioid cell monophasic fibrous spindle cell M-9040/3 M-9040/0 M-9040/3 Synovioma NOS benign malignant M-8400/0 M-8406/0 M-8406/0 M-8406/0 M-8392/0 Synovitis, pigmented villonodular (see SNOMED) Syringadenoma, NOS (C44._) Syringadenoma, papillary (C44._) Syringocystadenoma, papillary (C44._) Syringocystadenoma papilliferum (C44._) Syringofibroadenoma (C44._) M-8407/0 M-8940/0 M-8940/3 Syringoma NOS (C44._) chondroid (C44._) chondroid, malignant (C44._) M--------- Tail C25.2 C50.6 C50.6 M-9837/3 M-9837/3 M-8344/3 M-9391/3 T ALL, cortical (see also M-9729/3) T ALL, mature (see also M-9729/3) Tall cell papillary carcinoma (C73.9) Tanycytic ependymoma (C71._) C71.8 C40.3 Tapetum Tarsal bone M-9183/3 Telangiectatic osteosarcoma (C40._, C41._) M-8407/3 Syringomatous carcinoma (C44._) M--------M-9769/1 M--------M-9741/3 pancreas breast, NOS breast, axillary Systemic hemangiomatosis (see SNOMED) light chain disease lymphangiomatosis (see SNOMED) tissue mast cell disease T M-------/-5 T-cell (see cell designation code, page 36) M-9831/1 T-cell large granular lymphocytosis M-9718/3 T-cell lymphoproliferative disorder, primary cutaneous CD30+ (C44._) M-9768/1 T-gamma lymphoproliferative disease 227 C44.3 C44.3 C49.0 C49.0 C47.0 C49.0 C49.0 C49.0 C47.0 C44.3 C49.0 C49.0 Temple NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue C41.0 C71.2 C41.1 Temporal bone Temporal lobe Temporomandibular joint C49.9 C49.2 C49.1 C49.6 C49.2 C49.1 C49.6 C49.2 C49.1 C49.1 C49.2 C49.2 C49.2 C49.2 C49.0 C49.2 C49.2 C49.1 C49.2 C49.1 Tendon NOS ankle arm back calf finger flank foot forearm hand heel hip knee leg neck popliteal space thigh thumb toe wrist C49.9 C49.2 C49.1 C49.6 C49.2 C49.1 Tendon sheath NOS ankle arm back calf finger Alphabetic Index C49.2 C49.1 C49.1 C49.2 C49.2 C49.2 C49.2 C49.0 C49.2 C49.2 C49.1 C49.2 C49.1 M-8640/1 Testicular adenoma (C62._) M-8590/1 Testicular stromal tumor (C62._) Tendon sheath, continued foot forearm hand heel hip knee leg neck popliteal space thigh thumb toe wrist Tentorium, NOS Tentorium cerebelli M-9987/3 M-9987/3 M-9987/3 Teratoma NOS adult, NOS adult, cystic anaplastic, malignant and embryonal carcinoma, mixed and seminoma, mixed benign combined with choriocarcinoma cystic, NOS cystic, adult differentiated embryonal immature, NOS immature, malignant intermediate, malignant Malignant NOS anaplastic intermediate trophoblastic undifferentiated M-9080/0 M-9080/1 M-9102/3 M-9082/3 M-9084/3 mature solid trophoblastic, malignant undifferentiated, malignant with malignant transformation M-8525/3 Terminal duct adenocarcinoma C62.9 Thalamus Thecoma NOS (C56.9) luteinized (C56.9) malignant (C56.9) Therapy-related Acute myeloid leukemia M-9920/3 NOS M-9920/3 alkylating agent related M-9920/3 epipodophyllotoxin related Teratoblastoma, malignant Teratocarcinoma Teratoid medulloepithelioma (C69.4) Teratoid medulloepithelioma, benign (C69.4) M-9508/3 Teratoid/rhabdoid tumor, atypical (C71._) M-9080/3 M-9082/3 M-9083/3 M-9102/3 M-9082/3 C71.0 M-8600/0 M-8601/0 M-8600/3 M-9080/3 M-9081/3 M-9502/3 M-9502/0 M-9080/1 M-9080/0 M-9080/0 M-9082/3 M-9081/3 M-9085/3 M-9080/0 M-9101/3 M-9080/0 M-9080/0 M-9080/0 M-9080/3 M-9080/3 M-9080/3 M-9083/3 Testis NOS descended ectopic (site of neoplasm) retained (site of neoplasm) scrotal undescended (site of neoplasm) M-8621/1 Theca cell-granulosa cell tumor (C56.9) M-8600/0 Theca cell tumor (C56.9) M-9252/0 Tenosynovial giant cell tumor (C49._) M-9252/3 Tenosynovial giant cell tumor, malignant (C49._) M---------- Tenosynovitis, nodular (see SNOMED) C70.0 C70.0 C62.9 C62.1 C62.0 C62.0 C62.1 C62.0 Testicle, NOS 228 Myelodysplastic syndrome NOS alkylating agent related epipodophyllotoxin related C76.5 C44.7 C49.2 C49.2 C47.2 C49.2 C49.2 C49.2 C49.2 C47.2 C49.2 C44.7 C49.2 C49.2 C49.2 C49.2 Thigh NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath C71.5 C71.5 Third ventricle, NOS Third ventricle, choroid plexus C72.0 C49.3 C15.1 C77.1 Thoracic cord duct esophagus lymph node C76.1 C44.5 C49.3 Thoracic wall NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) Alphabetic Index C49.3 C47.3 C49.3 C49.3 C49.3 C49.3 C47.3 C49.3 C44.5 C49.3 C49.3 Thoracic wall, continued adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C49.3 C47.3 C49.3 C44.5 C49.3 Thorax NOS autonomic nervous system connective tissue (excludes thymus, heart and mediastinum C37._,C38._) muscle peripheral nerve skeletal muscle skin subcutaneous tissue C14.0 Throat M-9962/3 M-9962/3 M-9962/3 M-9962/3 Thrombocythemia essential (C42.1) essential, hemorrhagic (C42.1) idiopathic (C42.1) idiopathic, hemorrhagic (C42.1) C76.4 C44.6 C49.1 C47.1 C40.1 C49.1 C49.1 C49.1 C47.1 C49.1 C44.6 C49.1 C49.1 C49.1 C49.1 Thumb NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system bone connective tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue tendon tendon sheath C76.1 C47.3 C49.3 C37.9 Thymus Thymus-like differentiation, carcinoma showing differentiation, spindle epithelial tumor with thymus-like M-8589/3 element, carcinoma showing M-8588/3 element, spindle epithelial tumor with M-8589/3 M-8588/3 M-8586/3 Thymic carcinoma, NOS (C37.9) M-8585/3 Thymic carcinoma, well differentiated (C37.9) M-8580/1 M-8580/3 M-8585/1 M-8585/3 M-8580/0 M-8584/1 M-8584/3 M-8587/0 M-8585/1 M-8581/1 M-8581/3 M-8581/1 M-8581/3 M-8582/1 M-8582/3 M-8583/1 M-8583/3 M-8584/1 M-8584/3 M-8585/1 M-8585/3 M-8586/3 Thymoma, continued epithelial, malignant (C37.9) hamartomatous, ectopic lymphocyte-rich, NOS (C37.9) lymphocyte-rich, malignant (C37.9) lymphocytic, NOS (C37.9) lymphocytic, malignant (C37.9) malignant, NOS (C37.9) medullary, NOS (C37.9) medullary, malignant (C37.9) mixed type, NOS (C37.9) mixed type, malignant (C37.9) organoid, NOS (C37.9) organoid, malignant (C37.9) predominantly cortical, NOS (C37.9) predominantly cortical, malignant (C37.9) spindle cell, NOS (C37.9) spindle cell, malignant (C37.9) type A, NOS (C37.9) type A, malignant (C37.9) type AB, NOS (C37.9) type AB, malignant (C37.9) type B1, NOS (C37.9) type B1, malignant (C37.9) type B2, NOS (C37.9) type B2, malignant (C37.9) type B3, NOS (C37.9) type B3, malignant (C37.9) type C (C37.9) M-8585/3 M-8587/0 M-8583/1 M-8583/3 M-8583/1 M-8583/3 M-8580/3 M-8581/1 M-8581/3 M-8582/1 M-8582/3 M-8583/1 M-8583/3 M-8583/1 M-8583/3 C73.9 Thyroglossal duct M--------- Thyroglossal duct cyst (see SNOMED) C73.9 C32.3 C73.9 Thyroid NOS cartilage gland C40.2 Tibia M-9261/3 Tibial adamantinoma (C40.2) C77.4 C02.1 Thymoma NOS (C37.9) NOS, malignant (C37.9) atypical, NOS (C37.9) atypical, malignant (C37.9) benign (C37.9) cortical, NOS (C37.9) cortical, malignant (C37.9) ectopic hamartomatous epithelial, NOS (C37.9) Tibial lymph node Tip of tongue Toe C76.5 C44.7 C49.2 C47.2 C40.3 C49.2 229 NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system bone connective tissue Alphabetic Index C49.2 C49.2 C47.2 C49.2 C44.7 C44.7 C49.2 C49.2 C49.2 C49.2 Toe, continued fibrous tissue muscle peripheral nerve skeletal muscle nail skin soft tissue subcutaneous tissue tendon tendon sheath C02.9 C02.3 C02.0 C02.2 C02.3 C02.0 C02.2 C01.9 C01.9 C02.1 C02.0 C01.9 C02.2 C02.8 C02.9 C02.4 C02.0 C01.9 C01.9 C01.9 C02.1 C02.2 C02.2 C02.2 Tongue NOS anterior, NOS anterior, dorsal surface anterior, ventral surface anterior 2/3, NOS anterior 2/3, dorsal surface anterior 2/3, ventral surface base, NOS base, dorsal surface border dorsal surface, NOS dorsal surface of base frenulum linguae junctional zone lingual, NOS lingual tonsil midline posterior, NOS posterior third root tip ventral surface, NOS ventral surface, anterior ventral surface, anterior 2/3 C09.9 C02.4 C09.9 C11.1 Tonsil NOS (excludes lingual tonsil C02.4 and pharyngeal tonsil C11.1) faucial lingual palatine pharyngeal C09.0 C09.1 C03.9 Tonsillar fossa Tonsillar pillar Tooth socket M-8190/3 M-8190/0 M-8336/0 M-8190/3 M-8332/3 M-8332/3 Trabecular adenocarcinoma adenoma adenoma, hyalinizing (C73.9) carcinoma follicular adenocarcinoma (C73.9) follicular carcinoma (C73.9) C33.9 C77.1 C77.1 Trachea Tracheal lymph node Tracheobronchial lymph node C09.9 C26.9 C24.9 C57.9 C26.9 C57.9 C63.9 C26.0 C63.9 C72.3 C39.9 C39.0 C69.4 Tract alimentary, NOS biliary, NOS female genital, NOS gastrointestinal, NOS genitourinary, female, NOS genitourinary, male, NOS intestinal, NOS male genital, NOS optic respiratory, NOS upper respiratory, NOS uveal C44.2 Tragus M-9084/3 Transformation, malignant, dermoid cyst with (C56.9) M-9084/3 Transformation, malignant, teratoma with M-8120/3 M-9537/0 M-8120/0 M-8121/1 M-8121/0 M-9362/3 Transitional carcinoma meningioma (C70._) papilloma papilloma, inverted, NOS papilloma, inverted, benign pineal tumor (C75.3) M-8120/3 M-8120/2 M-8131/3 M-8130/3 M-8130/2 M-8122/3 M-8122/3 Transitional cell Carcinoma NOS in situ micropapillary (C67._) papillary (C67._) papillary, non-invasive (C67._) sarcomatoid spindle cell M-8130/1 M-8120/1 M-8120/0 M-8121/1 M-8121/0 neoplasm, papillary, low malignant potential (C67._) Papilloma NOS benign inverted, NOS inverted, benign C18.4 C49.3 Transverse colon Trapezius muscle M--------- Traumatic neuroma (see SNOMED) C06.2 C49.1 Triangle, retromolar Triceps brachii muscle M-8102/3 M-8103/0 M-8103/0 Trichilemmal carcinoma (C44._) cyst, proliferating tumor, proliferating M-8102/3 Trichilemmocarcinoma (C44._) M-8102/0 Trichilemmoma (C44._) M-8391/0 Trichodiscoma (C44._) 230 Alphabetic Index M-8100/0 Trichoepithelioma (C44._) M-8101/0 Trichofolliculoma (C44._) C72.5 C67.0 C06.2 M-8623/1 Tubules, annular, sex cord tumor with (C56.9) M-8263/3 Tubulopapillary adenocarcinoma Trigeminal nerve Trigone, bladder Trigone, retromolar M-8263/0 M-8263/3 M-8263/2 M-9561/3 Triton tumor, malignant C72.5 Trochlear nerve M-9102/3 M-9105/3 M-9104/1 Trophoblastic malignant teratoma tumor, epithelioid tumor, placental site (C58.9) C32.0 True cord M-9161/0 Tufted hemangioma, acquired M-8000/1 M-8550/1 M-8550/1 M-8245/3 M-9054/0 M-9300/0 M-8390/0 M-9755/3 True histiocytic lymphoma C32.0 True vocal cord C76.7 C44.5 C49.6 C49.6 C47.6 C49.6 C49.6 C49.6 C49.6 C47.6 C49.6 C44.5 C49.6 C49.6 Trunk NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue muscle peripheral nerve skeletal muscle skin soft tissue subcutaneous tissue C30.1 C30.1 C57.0 C57.0 Tube auditory eustachian fallopian uterine C57.8 Tubo-ovarian M-8211/3 Tubular adenocarcinoma M-8211/0 M-8210/3 M-8210/2 M-8640/1 M-8523/3 M-8640/1 M-8641/0 M-8245/1 M-8211/3 Tubulovillous adenoma NOS adenocarcinoma in adenocarcinoma in situ in M-8370/0 M-8370/0 M-8370/3 M--------M-8691/1 M-9365/3 M-8249/3 M-9508/3 M-8936/1 M-8090/1 M-8833/3 M-8000/0 M-8000/0 M-8151/3 M-9000/0 M-9000/1 M-9000/3 M-9000/1 Brenner NOS (C56.9) borderline malignancy (C56.9) malignant (C56.9) proliferating (C56.9) M-9133/3 M-8100/0 M-8880/0 M-9687/3 and infiltrating duct carcinoma (C50._) androblastoma, NOS androblastoma with lipid storage (C56.9) carcinoid carcinoma M-8240/3 M-8240/1 M-8240/1 M-8241/3 M-8249/3 M-8240/1 231 Adrenal cortical NOS (C74.0) benign (C74.0) malignant (C74.0) adrenal rest alpha cell, NOS (C25._) alpha cell, malignant (C25._) alveolar, intravascular bronchial (C34._) [obs] amyloid (see SNOMED) aortic body (C75.5) Askin atypical carcinoid atypical teratoid/rhabdoid (C71._) autonomic nerve, gastrointestinal basal cell (C44._) Bednar (C44._) benign benign, unclassified beta cell, malignant M-8671/0 M-8152/1 M-8152/3 M-9133/3 Adenoma NOS adenocarcinoma in adenocarcinoma in situ in Pick Tumor NOS acinar cell [obs] acinic cell [obs] adenocarcinoid adenomatoid, NOS adenomatoid, odontogenic (C41._) adnexal, benign (C44._) bronchial alveolar, intravascular (C34._) [obs] Brooke (C44._) brown fat Burkitt [obs] (includes all variants) Carcinoid NOS (except of appendix M-8240/1) NOS, appendix (C18.1) argentaffin, NOS argentaffin, malignant (except of appendix M-8240/1) atypical uncertain malignant potential Alphabetic Index M-8692/1 M-8001/1 M-8001/0 M-8001/3 M-8001/1 M-9473/3 M-9230/0 M-8700/0 Tumor, continued carotid body (C75.4) central primitive neuroectodermal, NOS (C71._) chondromatous giant cell (C40._, C41._) chromaffin M-8005/3 Clear cell NOS atypical proliferating (C56.9) cystic, borderline malignancy (C56.9) type, malignant M-9230/0 Codman (C40._, C41._) M-8005/0 M-8444/1 M-8444/1 M-8452/1 Cystic and solid (C25._) atrio-ventricular node (C38.0) clear cell, borderline malignancy (C56.9) mucinous, with moderate dysplasia (C25._) papillary (C25._) M-9135/1 M-9758/3 M-8806/3 M-9413/0 M-8000/6 M-9071/3 M-8380/1 M-8380/1 M-8242/3 M-8010/0 M-8010/3 M-9260/3 M-8835/1 M-8842/0 Dabska dendritic cell, follicular desmoplastic small round cell dysembryoplastic neuroepithelial embolus endodermal sinus endometrioid, atypical proliferative endometrioid, low malignant potential enterochromaffin-like cell, malignant epithelial, benign epithelial, malignant Ewing (C40._, C41._) fibrohistiocytic, plexiform fibromyxoid, ossifying M-8815/0 M-8815/0 M-8815/3 Fibrous localized solitary solitary, malignant M-9758/3 M-8004/3 M-8153/1 M-8153/3 M-8153/1 M-8153/3 follicular dendritic cell fusiform cell type, malignant G cell, NOS G cell, malignant gastrin cell tumor gastrin cell tumor, malignant M-8936/1 Gastrointestinal autonomic nerve M-8452/1 M-8454/0 M-8444/1 M-8470/1 M-8936/1 M-8936/1 M-8936/0 M-8936/3 M-8936/1 Cells NOS benign malignant uncertain whether benign or malignant M-9064/3 M-9085/3 M-9065/3 Germ cell NOS mixed nonseminomatous (C62._) M-9302/0 ghost cell, odontogenic (C41._) M-9250/1 M-9250/3 M-9230/0 M-9251/1 M-9251/3 M-9252/0 M-9252/3 M-9252/0 M-9252/3 M-8003/3 Giant cell bone, NOS (C40._, C41._) bone, malignant (C40._, C41._) chondromatous (C40._, C41._) soft parts, NOS soft parts, malignant tendon sheath (C49._) tendon sheath, malignant (C49._) tenosynovial (C49._) tenosynovial, malignant (C49._) type, malignant M-8711/0 M-8690/1 M-8711/3 Glomus NOS jugulare, NOS (C75.5) malignant M-8590/1 gonadal stromal M-8590/1 M-8591/1 M-8592/1 Gonadal stromal-sex cord NOS incompletely differentiated mixed forms M-9580/0 M-9580/3 M-9582/0 Granular cell NOS malignant sellar region (C75.1) M-8620/1 M-8620/1 M-8622/1 M-8620/3 M-8620/3 Granulosa cell NOS (C56.9) adult type (C56.9) juvenile (C56.9) malignant (C56.9) sarcomatoid (C56.9) M-8621/1 M-8312/3 M-8660/0 M-8660/0 M-8290/0 M-8311/1 granulosa cell-theca cell (C56.9) Grawitz [obs] (C64.9) hilar cell (C56.9) hilus cell (C56.9) Hurthle cell (C73.9) hypernephroid [obs] M-8650/1 M-8650/0 M-8650/3 Interstitial cell NOS benign malignant M-8453/1 232 Tumor, continued Gastrointestinal pacemaker cell stromal, NOS stromal, benign stromal, malignant stromal, uncertain malignant potential intraductal papillary-mucinous, with moderate dysplasia (C25._) Alphabetic Index M-9133/3 M-8150/1 M-8150/0 M-8622/1 M-8361/0 M-8162/3 M-8490/6 Tumor, continued intravascular bronchial alveolar (C34._) [obs] islet cell, NOS (C25._) islet cell, benign (C25._) juvenile granulosa cell (C56.9) juxtaglomerular (C64.9) Klatskin (C22.1, C24.0) Krukenberg M-8650/1 M-8650/0 M-8650/3 Leydig cell NOS (C62._) benign (C62._) malignant (C62._) M-8631/0 M-8670/0 M-8670/0 Leydig-Sertoli cell, well differentiated lipid cell, ovary (C56.9) lipoid cell, ovary (C56.9) M-8000/3 M-8005/3 M-8004/3 M-8003/3 M-8800/3 M-8940/3 M-8940/3 M-9540/3 M-8002/3 M-8004/3 M-8000/3 M-8000/9 M-9740/1 M-9740/3 M-9363/0 M-8247/3 M-8800/3 M-8990/1 M-8951/3 M-9110/1 M-8000/6 M-8940/0 M-9085/3 M-8940/3 M-8990/1 M-8951/3 M-8940/0 M-8940/3 M-8472/1 M-8472/1 M-8470/1 Tumor, continued Mucinous, continued M-8472/1 NOS, of low malignant potential (C56.9) M-8473/1 papillary, of low malignant potential (C56.9) M-8243/3 M-8430/1 M-8950/3 M-8982/0 mucinous-papillary, intraductal, with moderate dysplasia (C25._) mucocarcinoid mucoepidermoid [obs] Mullerian mixed (C54._) myoepithelial M-8825/1 M-8827/1 M-8825/1 M-8827/1 Myofibroblastic NOS congenital peribronchial inflammatory peribronchial (C34._) M-8453/1 Malignant NOS clear cell type fusiform cell type giant cell type mesenchymal mixed, NOS mixed, salivary gland type (C07._, C08._) peripheral nerve sheath small cell type spindle cell type unclassified unclassified, uncertain whether primary or metastatic M-9540/3 M-9561/3 mast cell, NOS mast cell, malignant melanotic neuroectodermal Merkel cell (C44._) mesenchymal, malignant mesenchymal, mixed mesodermal mixed mesonephric, NOS metastatic Mixed NOS germ cell malignant, NOS mesenchymal mesodermal salivary gland type, NOS (C07._, C08._) salivary gland type, malignant (C07._, C08._) M-9364/3 M-9473/3 M-9363/0 M-9364/3 M-9473/3 Neuroectodermal NOS central primitive, NOS (C71._) melanotic peripheral primitive, NOS M-9413/0 M-9520/3 M-8350/3 M-9065/3 neuroepithelial, dysembryoplastic neurogenic, olfactory nonencapsulated sclerosing (C73.9) nonseminomatous germ cell (C62._) M-9270/1 M-9300/0 M-9270/0 M-9340/0 M-9341/1 M-9302/0 M-9270/3 M-9312/0 Odontogenic NOS (C41._) adenomatoid (C41._) benign (C41._) calcifying epithelial (C41._) clear cell (C41._) ghost cell (C41._) malignant (C41._) squamous (C41._) M-9520/3 M-8842/0 M-8967/0 M-8590/1 M-8936/1 M-9507/0 olfactory neurogenic ossifying fibromyxoid ossifying renal (C64.9) ovarian stromal (C56.9) pacemaker cell, gastrointestinal Pacinian M-8452/1 M-8473/1 Mucinous atypical proliferative (C56.9) cystic, of borderline malignancy (C56.9) cystic, with moderate dysplasia (C25._) M-8462/1 M-8462/1 233 nerve sheath, malignant peripheral nerve sheath, malignant peripheral, with rhabdomyoblastic differentiation Papillary cystic (C25._) mucinous, of low malignant potential (C56.9) serous, atypical proliferative (C56.9) serous, of low malignant potential (C56.9) Alphabetic Index Tumor, continued papillary-mucinous, intraductal, with moderate dysplasia (C25._) M-9362/3 parenchymal, pineal, intermediate differentiation (C75.3) Tumor, continued Serous, continued M-8463/1 surface papillary, of borderline malignancy (C56.9) M-8453/1 M-9540/3 M-9561/3 M-9364/3 M-9364/3 Peripheral nerve sheath, malignant nerve sheath, malignant, with rhabdomyoblastic differentiation neuroectodermal primitive neuroectodermal, NOS M-8640/1 M-8642/1 M-8641/0 M-8641/0 Sertoli cell NOS (C56.9) large cell calcifying lipid-rich (C56.9) with lipid storage M-9020/1 M-9020/0 M-9020/1 M-9020/3 Phyllodes NOS (C50._) benign (C50._) borderline (C50._) malignant (C50._) M-8103/0 M-9340/0 pilar (C44._) Pindborg (C41._) M-8633/1 M-8634/1 M-9362/3 M-9362/3 M-8631/3 M-8631/0 M-9362/3 Pineal mixed (C75.3) parenchymal, intermediate differentiation (C75.3) transitional (C75.3) Sertoli-Leydig cell NOS intermediate differentiation intermediate differentiation, with heterologous elements poorly differentiated poorly differntiated, with heterologous elements retiform retiform, with heterologous elements sarcomatoid well differentiated M-8590/1 M-8623/1 sex cord, NOS sex cord, with annular tubules (C56.9) M-8093/3 M-9104/1 M-9731/3 M-8835/1 M-9071/3 Pinkus placental site trophoblastic (C58.9) plasma cell plexiform fibrohistiocytic polyvesicular vitelline M-8590/1 M-8591/1 M-8592/1 Sex cord-gonadal stromal NOS incompletely differentiated mixed forms M-9473/3 M-9473/3 M-9364/3 Primitive neuroectodermal NOS central, NOS (C71._) peripheral, NOS M-8103/0 M-8452/1 M-9350/1 M-8967/0 M-8966/0 M-9363/0 M-8963/3 M-8963/3 M-9508/3 M-8806/3 M-8082/3 M-8350/3 M-8602/0 M-8000/6 M-9084/3 proliferating trichilemmal pseudopapillary, solid (C25._) Rathke pouch (C75.1) renal, ossifying (C64.9) renomedullary interstitial cell (C64.9) retinal anlage rhabdoid, NOS rhabdoid, malignant rhabdoid/teratoid, atypical (C71._) round cell, desmoplastic small Schmincke (C11._) sclerosing, nonencapsulated (C73.9) sclerosing stromal (C56.9) secondary secondary, dermoid cyst with M-9071/3 M-8390/0 M-8002/3 M-8806/3 M-8897/1 M-8897/1 M-8442/1 M-8442/1 M-8462/1 M-8462/1 M-8631/1 M-8631/1 M-8634/1 M-8631/3 M-8634/3 M-8800/0 M-8800/3 M-8452/1 M-8156/1 M-8156/3 M-8004/3 M-8588/3 M-8588/3 Serous NOS, of low malignant potential (C56.9) atypical proliferating (C56.9) papillary cystic, of borderline malignancy (C56.9) papillary, of low malignant potential (C56.9) 234 sinus, endodermal skin appendage, benign (C44._) small cell type, malignant small round cell, desmoplastic smooth muscle, NOS smooth muscle, uncertain malignant potential soft tissue, benign soft tissue, malignant solid and cystic (C25._) somatostatin cell tumor, NOS somatostatin cell tumor, malignant Spindle cell type, malignant epithelial, with thymus-like differentiation epithelial, with thymus-like element M-9312/0 M-8670/0 M-8670/3 squamous odontogenic (C41._) steroid cell, NOS steroid cell, malignant M-8935/1 M-8935/0 M-8936/0 M-8936/3 Stromal NOS benign gastrointestinal, benign gastrointestinal, malignant Alphabetic Index Tumor, continued Stromal, continued M-8936/1 gastrointestinal, uncertain malignant potential M-8602/0 sclerosing (C56.9) M-8593/1 with minor sex cord elements (C56.9) M-8400/1 M-8400/0 M-8400/3 M-9252/0 M-9252/3 M-9508/3 M-8590/1 M-8600/0 M-8621/1 M-9362/3 M-8103/0 M-9561/3 M-9105/3 M-9104/1 M-8200/0 M-8000/0 M-8000/1 M-8000/3 M-8000/9 M-8000/1 M-9071/3 M-8561/0 M-8960/3 M-9110/1 M-9071/3 M-9071/3 Sweat gland NOS (C44._) benign (C44._) malignant (C44._) tenosynovial giant cell (C49._) tenosynovial giant cell, malignant (C49._) teratoid/rhabdoid, atypical (C71._) testicular stromal (C62._) theca cell (C56.9) theca cell-granulosa cell (C56.9) transitional pineal (C75.3) trichilemmal, proliferating Triton, malignant trophoblastic, epithelioid trophoblastic, placental site (C58.9) turban (C44.4) C44.5 C44.5 C49.4 C47.4 C49.4 C49.4 C47.4 C44.5 C49.4 C49.4 Umbilicus NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) autonomic nervous system connective tissue fibrous tissue peripheral nerve skin soft tissue subcutaneous tissue M-8240/1 M-8936/1 M-8897/1 Uncertain malignant potential tumor, carcinoid tumor, gastrointestinal stromal tumor, smooth muscle Unclassified tumor benign borderline malignancy malignant malignant, uncertain whether primary or metastatic M-8000/1 uncertain whether benign or malignant Unclassified benign borderline malignancy malignant malignant, uncertain whether primary or metastatic uncertain whether benign or malignant M-8000/0 M-8000/1 M-8000/3 M-8000/9 C71.2 C62.0 vitelline, polyvesicular Warthin (C07._, C08._) Wilms (C64.9) Wolffian duct yolk sac yolk sac, hepatoid Uncus Undescended testis (site of neoplasm) M-9765/1 Undetermined significance, monoclonal gammopathy of M-------/-4 Undifferentiated (see grading code, page 34) M-8020/3 M-9512/3 M-8805/3 M-9082/3 Tunica vaginalis Undifferentiated carcinoma, NOS retinoblastoma (C69.2) sarcoma teratoma, malignant M-9752/1 Unifocal Langerhans cell granulomatosis M-9752/1 Unifocal Langerhans cell histiocytosis M-8200/0 Turban tumor (C44.4) C30.0 C30.1 Ulna Ulnar artery Ulnar nerve M-------/1 Uncertain whether benign or malignant (see behavior code, page 31) M-------/9 Uncertain whether primary or metastatic site (see behavior code, page 31) M-------- Tumoral calcinosis (see SNOMED) M-8040/1 Tumorlet, NOS M-8040/0 Tumorlet, benign C63.7 C40.0 C49.1 C47.1 Turbinate, nasal Tympanic cavity C80.9 Unknown primary site M-8480/3 Unknown primary site, pseudomyxoma peritonei with (C80.9) M-8240/3 Typical carcinoid C03.0 C03.0 C03.0 C50.8 C03.0 U M-8090/3 Ulcer, rodent (C44._) 235 Upper alveolar mucosa alveolar ridge mucosa alveolus breast gingiva Alphabetic Index C00.0 C00.3 C00.3 C00.3 C44.0 C00.0 C34.1 C34.1 C50.4 C39.0 C15.3 Upper, continued gum inner quadrant of breast jaw bone lid lip, NOS (excludes skin of upper lip C44.0) lip, external lip, frenulum lip, inner aspect lip, mucosa lip, skin lip, vermilion border lobe, bronchus lobe, lung outer quadrant of breast respiratory tract, NOS third of esophagus C76.4 C44.6 C49.1 C49.1 C47.1 C49.1 C49.1 C49.1 C40.0 C40.0 C77.3 C49.1 C47.1 C49.1 C40.1 C40.1 C44.6 C49.1 C49.1 C49.1 C49.1 Upper limb NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) adipose tissue autonomic nervous system connective tissue fatty tissue fibrous tissue long bone long bones, joints lymph node muscle peripheral nerve skeletal muscle short bone short bones, joints skin soft tissue subcutaneous tissue tendon tendon sheath C67.7 C66.9 C67.6 C68.0 C68.0 C67.5 C57.9 C67.9 C68.9 Urachus Ureter Ureteric orifice Urethra Urethral gland Urethral orifice, internal Urethrovaginal septum Urinary bladder, NOS (see also bladder) Urinary system, NOS C03.0 C50.2 C41.0 C44.1 C00.0 C55.9 C57.4 C53.9 C57.3 C54.0 C57.0 Uterine NOS adnexa cervix ligament lower segment tube C57.8 C57.3 Utero-ovarian Uterosacral ligament C55.9 C57.4 C57.4 C54.9 C53.0 C53.8 C53.9 C53.8 C53.9 C54.9 C53.0 C53.0 C53.0 C54.1 C54.1 C54.1 C53.1 C53.1 C58.9 C54.3 C53.0 C54.0 C57.1 C57.2 C57.3 C57.3 C54.0 C54.2 C53.0 C57.3 C58.9 C53.8 C57.4 C53.9 Uterus NOS adnexa, NOS adnexa, uterine body cervical canal cervical stump cervix, NOS cervix, squamocolumnar junction cervix uteri corpus uteri endocervical canal endocervical gland endocervix endometrial gland endometrial stroma endometrium exocervix external os fetal membranes fundus uteri internal os isthmus uteri ligament, broad ligament, round ligament, uterine ligament, uterosacral lower uterine segment myometrium Nabothian gland parametrium placenta squamocolumnar junction of cervix uterine adnexa uterine cervix M-8890/0 Uterus, fibroid (C55.9) C68.0 C69.4 C05.2 Urothelial carcinoma, NOS (C67._) carcinoma in situ (C67._) carcinoma, papillary (C67._) carcinoma, papillary, non-invasive (C67._) M-8130/1 neoplasm, papillary, of low malignant potential (C67._) M-8120/1 papilloma, NOS (C67._) Utricle, prostatic Uveal tract Uvula M-8120/3 M-8120/2 M-8130/3 M-8130/2 V C52.9 C52.9 Vagina, NOS Vagina, fornix M-8077/2 Vaginal intraepithelial neoplasia, grade III (C52._) 236 Alphabetic Index C52.9 C72.5 Vaginal vault Vagus nerve C41.2 C41.2 M-8077/2 VAIN III (C52._) Vertebra Vertebral column (excludes sacrum and coccyx C41.4) Vesicle, seminal Vesicocervical tissue Vesicovaginal septum Vessel, NOS Vestibule of mouth Vestibule of nose C10.0 C18.0 C63.1 Vallecula Valve, ileocecal Vas deferens C63.7 C57.9 C57.9 C49.9 C06.1 C30.0 M-8894/0 M--------M--------- Vascular leiomyoma nevus (see SNOMED) spider (see SNOMED) M-8263/0 Villoglandular adenoma M--------- Villonodular pigmented synovitis (see SNOMED) C52.9 C49.9 C49.5 Vault, vaginal Vein, NOS Vein, iliac C49.4 C49.4 C49.4 C49.3 Vena cava NOS abdominal inferior superior M-8262/3 M-8261/0 M-8261/3 M-8261/2 M-8261/0 M-8077/2 VIN III (C51._) M-8155/1 Vipoma, NOS M-8155/3 Vipoma, malignant M-9122/0 Venous hemangioma C38.4 C02.2 C02.2 C02.2 Ventral surface of tongue NOS anterior anterior 2/3 C71.5 C38.0 C71.5 C71.7 C71.7 C71.5 C71.5 C71.5 C71.5 Ventricle NOS cardiac cerebral fourth, NOS fourth, choroid plexus lateral, NOS lateral, choroid plexus third, NOS third, choroid plexus C32.1 Ventricular band of larynx C00.2 C00.1 C00.0 Vermilion border lip, NOS lower lip upper lip C71.6 Vermis of cerebellum M--------M--------M--------M--------- Verruca NOS (see SNOMED) plana (see SNOMED) seborrheic (see SNOMED) vulgaris (see SNOMED) M-8051/3 M-8051/3 M-8051/3 M-9142/0 M-8051/0 Verrucous carcinoma, NOS carcinoma, epidermoid carcinoma, squamous cell keratotic hemangioma papilloma Villous adenocarcinoma adenoma, NOS adenoma, adenocarcinoma in adenoma, adenocarcinoma in situ in papilloma Visceral pleura M-9071/3 Vitelline tumor, polyvesicular C32.0 C32.1 C32.0 Vocal cord NOS false true M-9540/1 Von Recklinghausen disease (except of bone) M--------- Von Recklinghausen disease, bone (see SNOMED) C51.9 C51.9 Vulva, NOS Vulva, skin M-8077/2 Vulvar intraepithelial neoplasia, grade III (C51._) W M-9761/3 Waldenstrom macroglobulinemia (C42.0) (see also M-9671/3) C14.2 Waldeyer ring M--------- Walthard rest (see SNOMED) M-8561/0 Warthin tumor (C07._, C08._) M-8051/3 Warty carcinoma 237 Alphabetic Index M-8322/3 M-8322/0 M-8322/3 Water-clear cell adenocarcinoma (C75.0) adenoma (C75.0) carcinoma (C75.0) M--------- Y M-------/-1 Well differentiated (see grading code, page 34) M-9071/3 Yolk sac tumor M-9071/3 Yolk sac tumor, hepatoid Well differentiated M-8331/3 follicular adenocarcinoma (C73.9) M-8331/3 follicular carcinoma (C73.9) M-8851/3 M-8850/1 M-8850/1 Liposarcoma NOS superficial superficial soft tissue M-9187/3 M-9052/0 M-8631/0 M-8585/3 osteosarcoma, intraosseous papillary mesothelioma, benign Sertoli-Leydig cell tumor thymic carcinoma (C37.9) C08.0 C71.0 C71.0 Z C21.2 C02.8 C75.5 C41.0 Wharton duct White matter, central White matter, cerebral M--------- White sponge nevus (see SNOMED) M-8960/3 Wilms tumor (C64.9) C25.3 C57.7 C57.7 Wirsung duct Wolffian body Wolffian duct M-9110/0 M-9110/3 M-9110/1 Wolffian duct adenoma carcinoma tumor C76.4 C44.6 C49.1 C40.1 C49.1 C49.1 C40.1 C44.6 C49.1 C49.1 C49.1 C49.1 Wrist NOS NOS (carcinoma, melanoma, nevus) NOS (sarcoma, lipoma) bone connective tissue fibrous tissue joint skin soft tissue subcutaneous tissue tendon tendon sheath X M-9424/3 M-8830/0 M--------M--------M--------- Xeroderma pigmentosum (see SNOMED) Xanthoastrocytoma, pleomorphic (C71._) Xanthofibroma Xanthogranuloma, NOS (see SNOMED) Xanthogranuloma, juvenile (see SNOMED) Xanthoma, NOS (see SNOMED) 238 Zone, cloacogenic Zone, junctional of tongue Zuckerkandl organ Zygomatic bone Appendix 1: New ICD-O, Third Edition, Codes APPENDIX 1: NEW ICD-O, THIRD EDITION, CODES (The following 4-digit morphology codes did not exist in ICD-O, Second Edition.) A term without a number is a synonym for the preceding code. 8005/0 8005/3 8013/3 8014/3 8015/3 8035/3 8046/3 8078/3 8083/3 8084/3 8097/3 8098/3 8103/0 8131/3 8148/2 8149/0 8156/1 8156/3 8157/1 8157/3 8172/3 8173/3 8174/3 8175/3 8204/0 8212/0 8213/0 8214/3 8215/3 8242/1 8242/3 8249/3 Clear cell tumor, NOS Malignant tumor, clear cell type Large cell neuroendocrine carcinoma Large cell carcinoma with rhabdoid phenotype Glassy cell carcinoma Carcinoma with osteoclast-like giant cells Non-small cell carcinoma (C34._) Squamous cell carcinoma with horn formation Basaloid squamous cell carcinoma Squamous cell carcinoma, clear cell type Basal cell carcinoma, nodular (C44._) Basal cell carcinoma, micronodular (C44._) Adenoid basal carcinoma (C53._) Pilar tumor (C44._) Proliferating trichilemmal cyst Proliferating trichilemmal tumor Transitional cell carcinoma, micropapillary (C67._) Glandular intraepithelial neoplasia, grade III Prostatic intraepithelial neoplasia, grade III (C61.9) PIN III (C61.9) Canalicular adenoma Somatostatinoma, NOS Somatostatin cell tumor, NOS Somatostatinoma, malignant Somatostatin cell tumor, malignant Enteroglucagonoma, NOS Enteroglucagonoma, malignant Hepatocellular carcinoma, scirrhous (C22.0) Sclerosing hepatic carcinoma (C22.0) Hepatocellular carcinoma, spindle cell variant (C22.0) Hepatocellular carcinoma, sarcomatoid (C22.0) Hepatocellular carcinoma, clear cell type (C22.0) Hepatocellular carcinoma, pleomorphic type (C22.0) Lactating adenoma (C50._) Flat adenoma Serrated adenoma (C18._) Mixed adenomatous and hyperplastic polyp (C18._) Parietal cell carcinoma (C16._) Parietal cell adenocarcinoma (C16._) Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts (C21.1) Enterochromaffin-like cell carcinoid, NOS ECL cell carcinoid, NOS Enterochromaffin-like cell tumor, malignant ECL cell carcinoid, malignant Atypical carcinoid tumor 239 Appendix 1: New ICD-O, Third Edition, Codes 8252/3 8253/3 8254/3 8255/3 8264/0 8272/0 8272/3 8316/3 8317/3 8318/3 8319/3 8325/0 8335/3 8336/0 8337/3 8341/3 8342/3 8343/3 8344/3 8346/3 8347/3 8382/3 8383/3 8384/3 8391/0 8392/0 8409/3 8413/3 8443/0 8444/1 8453/0 8453/1 8453/2 8453/3 Bronchiolo-alveolar carcinoma, non-mucinous (C34._) Bronchiolo-alveolar carcinoma, Clara cell (C34._) Bronchiolo-alveolar carcinoma, type II pneumocyte (C34._) Broncholo-alveolar carcinoma, mucinous (C34._) Bronchiolo-alveolar carcinoma, goblet cell type (C34._) Bronchiolo-alveolar carcinoma, mixed mucinous and non-mucinous (C34._) Bronchiolo-alveolar carcinoma, Clara cell and goblet cell type (C34._) Bronchiolo-alveolar carcinoma, type II pneumocyte and goblet cell type (C34._) Bronchiolo-alveolar carcinoma, indeterminate type (C34._) Adenocarcinoma with mixed subtypes Adenocarcinoma combined with other types of carcinoma Papillomatosis, glandular Biliary papillomatosis (C22.1, C24.0) Pituitary adenoma, NOS (C75.1) Pituitary carcinoma, NOS (C75.1) Cyst-associated renal cell carcinoma (C64.9) Renal cell carcinoma, chromophobe cell (C64.9) Chromophobe cell renal carcinoma (C64.9) Renal cell carcinoma, sarcomatoid (C64.9) Renal cell carcinoma, spindle cell (C64.9) Collecting duct carcinoma (C64.9) Bellini duct carcinoma (C64.9) Renal carcinoma, collecting duct type (C64.9) Metanephric adenoma (C64.9) Follicular carcinoma, minimally invasive (C73.9) Follicular carcinoma, encapsulated (C73.9) Hyalinizing trabecular adenoma (C73.9) Insular carcinoma (C73.9) Papillary microcarcinoma (C73.9) Papillary carcinoma, oxyphilic cell (C73.9) Papillary carcinoma, encapsulated (C73.9) Papillary carcinoma, columnar cell (C73.9) Papillary carcinoma, tall cell (C73.9) Mixed medullary-follicular carcinoma (C73.9) Mixed medullary-papillary carcinoma (C73.9) Endometrioid adenocarcinoma, secretory variant Endometrioid adenocarcinoma, ciliated cell variant Adenocarcinoma, endocervical type Follicular fibroma (C44._) Trichodiscoma (C44._) Fibrofolliculoma (C44._) Perifollicular fibroma (C44._) Syringofibroadenoma (C44._) Eccrine poroma, malignant Porocarcinoma (C44._) Eccrine adenocarcinoma (C44._) Clear cell cystadenoma (C56.9) Clear cell cystic tumor of borderline malignancy (C56.9) Atypical proliferating clear cell tumor (C56.9) Intraductal papillary-mucinous adenoma (C25._) Intraductal papillary-mucinous tumor with moderate dysplasia (C25._) Intraductal papillary-mucinous carcinoma, non-invasive (C25._) Intraductal papillary-mucinous carcinoma, invasive (C25._) 240 Appendix 1: New ICD-O, Third Edition, Codes 8454/0 8463/1 8482/3 8507/2 8508/3 8513/3 8514/3 8523/3 8524/3 8525/3 8551/3 8574/3 8575/3 8576/3 8581/1 8581/3 8582/1 8582/3 8583/1 8583/3 8584/1 8584/3 8585/1 8585/3 Cystic tumor of atrio-ventricular node (C38.0) Serous surface papillary tumor of borderline malignancy (C56.9) Mucinous adenocarcinoma, endocervical type Intraductal micropapillary carcinoma (C50._) Ductal carcinoma in situ, micropapillary (C50._) Intraductal carcinoma, clinging (C50._) Cystic hypersecretory carcinoma (C50._) Atypical medullary carcinoma (C50._) Duct carcinoma, desmoplastic type Infiltrating duct mixed with other types of carcinoma (C50._) Infiltrating duct and cribriform carcinoma (C50._) Infiltrating duct and mucinous carcinoma (C50._) Infiltrating duct and tubular carcinoma (C50._) Infiltrating duct and colloid carcinoma (C50._) Infiltrating lobular mixed with other types of carcinoma (C50._) Polymorphous low grade adenocarcinoma Terminal duct adenocarcinoma Acinar cell cystadenocarcinoma Adenocarcinoma with neuroendocrine differentiation Carcinoma with neuroendocrine differentiation Metaplastic carcinoma, NOS Hepatoid adenocarcinoma Hepatoid carcinoma Thymoma, type A, NOS (C37.9) Thymoma, spindle cell, NOS (C37.9) Thymoma, medullary, NOS (C37.9) Thymoma, type A, malignant (C37.9) Thymoma, spindle cell, malignant (C37.9) Thymoma, medullary, malignant (C37.9) Thymoma, type AB, NOS (C37.9) Thymoma, mixed type, NOS (C37.9) Thymoma, type AB, malignant (C37.9) Thymoma, mixed type, malignant (C37.9) Thymoma, type B1, NOS (C37.9) Thymoma, lymphocyte-rich, NOS (C37.9) Thymoma, lymphocytic, NOS (C37.9) Thymoma, predominantly cortical, NOS (C37.9) Thymoma, organoid, NOS (C37.9) Thymoma, type B1, malignant (C37.9) Thymoma, lymphocyte-rich, malignant (C37.9) Thymoma, lymphocytic, malignant (C37.9) Thymoma, predominantly cortical, malignant (C37.9) Thymoma, organoid, malignant (C37.9) Thymoma, type B2, NOS (C37.9) Thymoma, cortical, NOS (C37.9) Thymoma, type B2, malignant (C37.9) Thymoma, cortical, malignant (C37.9) Thymoma, type B3, NOS (C37.9) Thymoma, epithelial, NOS (C37.9) Thymoma, atypical, NOS (C37.9) Thymoma, type B3, malignant (C37.9) Thymoma, epithelial, malignant (C37.9) Thymoma, atypical, malignant (C37.9) Well differentiated thymic carcinoma (C37.9) 241 Appendix 1: New ICD-O, Third Edition, Codes 8586/3 8587/0 8588/3 8589/3 8591/1 8592/1 8593/1 8633/1 8634/1 8634/3 8642/1 8728/0 8728/1 8728/3 8746/3 8762/1 8805/3 8806/3 8815/0 8815/3 8825/0 8825/1 8826/0 8827/1 8831/0 8834/1 8835/1 8836/1 8842/0 8862/0 8898/1 8905/0 8912/3 8921/3 8934/3 8935/1 8935/3 8936/0 Thymoma, type C (C37.9) Ectopic hamartomatous thymoma Spindle epithelial tumor with thymus-like element Spindle epithelial tumor with thymus-like differentiation SETTLE Carcinoma showing thymus-like element Carcinoma showing thymus-like differentiation CASTLE Sex cord-gonadal stromal tumor, incompletely differentiated Sex cord-gonadal stromal tumor, mixed forms Stromal tumor with minor sex cord elements (C56.9) Sertoli-Leydig cell tumor, retiform Sertoli-Leydig cell tumor, intermediate differentiation, with heterologous elements Sertoli-Leydig cell tumor, retiform, with heterologous elements Sertoli-Leydig cell tumor, poorly differentiated, with heterologous elements Large cell calcifying Sertoli cell tumor Diffuse melanocytosis (C70.9) Meningeal melanocytoma (C70.9) Meningeal melanomatosis (C70.9) Mucosal lentiginous melanoma Proliferative dermal lesion in congenital nevus (C44._) Undifferentiated sarcoma Desmoplastic small round cell tumor Solitary fibrous tumor Localized fibrous tumor Solitary fibrous tumor, malignant Myofibroblastoma Myofibroblastic tumor, NOS Inflammatory myofibroblastic tumor Angiomyofibroblastoma Myofibroblastic tumor, peribronchial (C34._) Congenital peribronchial myofibroblastic tumor (C34._) Deep histiocytoma Juvenile histiocytoma Reticulohistiocytoma Giant cell fibroblastoma Plexiform fibrohistiocytic tumor Angiomatoid fibrous histiocytoma Ossifying fibromyxoid tumor Chondroid lipoma Metastasizing leiomyoma Genital rhabdomyoma (C51._, C52.9) Spindle cell rhabdomyosarcoma Rhabdomyosarcoma with ganglionic differentiation Ectomesenchymoma Carcinofibroma Stromal tumor, NOS Stromal sarcoma, NOS Gastrointestinal stromal tumor, benign GIST, benign 242 Appendix 1: New ICD-O, Third Edition, Codes 8936/1 8936/3 8959/0 8959/1 8959/3 8965/0 8966/0 8967/0 8973/3 8974/1 8983/0 9065/3 9105/3 9135/1 9136/1 9186/3 9187/3 9193/3 9194/3 9195/3 9242/3 9243/3 9252/0 9252/3 9341/1 9342/3 9351/1 9352/1 9365/3 9371/3 9372/3 9373/0 9412/1 9413/0 Gastrointestinal stromal tumor, NOS GIST, NOS Gastrointestinal stromal tumor, uncertain malignant potential Gastrointestinal autonomic nerve tumor GANT Gastrointestinal pacemaker cell tumor Gastrointestinal stromal sarcoma Gastrointestinal stromal tumor, malignant GIST, malignant Benign cystic nephroma (C64.9) Cystic partially differentiated nephroblastoma (C64.9) Malignant cystic nephroma (C64.9) Malignant multilocular cystic nephroma (C64.9) Nephrogenic adenofibroma (C64.9) Renomedullary interstitial cell tumor (C64.9) Renomedullary fibroma (C64.9) Ossifying renal tumor (C64.9) Pleuropulmonary blastoma Sialoblastoma Adenomyoepithelioma (C50._) Germ cell tumor, nonseminomatous (C62._) Trophoblastic tumor, epithelioid Endovascular papillary angioendothelioma Dabska tumor Spindle cell hemangioendothelioma Spindle cell angioendothelioma Central osteosarcoma (C40._, C41._) Conventional central osteosarcoma (C40._, C41._) Medullary osteosarcoma (C40._, C41._) Intraosseous well differentiated osteosarcoma (C40._, C41._) Intraosseous low grade osteosarcoma (C40._, C41._) Periosteal osteosarcoma (C40._, C41._) High grade surface osteosarcoma (C40._, C41._) Intracortical osteosarcoma (C40._, C41._) Clear cell chondrosarcoma (C40._, C41._) Dedifferentiated chondrosarcoma (C40._, C41._) Tenosynovial giant cell tumor (C49._) Fibrous histiocytoma of tendon sheath (C49._) Giant cell tumor of tendon sheath (C49._) Malignant tenosynovial giant cell tumor (C49._) Giant cell tumor of tendon sheath, malignant (C49._) Clear cell odontogenic tumor Odontogenic carcinosarcoma Craniopharyngioma, adamantinomatous (C75.2) Craniopharyngioma, papillary (C75.2) Askin tumor Chondroid chordoma Dedifferentiated chordoma Parachordoma Desmoplastic infantile astrocytoma Desmoplastic infantile ganglioglioma Dysembryoplastic neuroepithelial tumor 243 Appendix 1: New ICD-O, Third Edition, Codes 9444/1 9474/3 9493/0 9508/3 9513/3 9514/1 9571/0 9571/3 9582/0 9596/3 9651/3 9678/3 9679/3 9689/3 9699/3 9708/3 9716/3 9717/3 9718/3 9719/3 9727/3 9728/3 9729/3 9751/1 9752/1 Chordoid glioma (C71._) Chordoid glioma of third ventricle (C71.5) Large cell medulloblastoma (C71.6) Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) (C71.6) Atypical teratoid/rhabdoid tumor (C71._) Retinoblastoma, diffuse (C69.2) Retinoblastoma, spontaneously regressed (C69.2) Perineurioma Intraneural perineurioma Soft tissue perineurioma Perineurioma, malignant Perineural MPNST Granular cell tumor of the sellar region (C75.1) Composite Hodgkin and non-Hodgkin lymphoma Hodgkin lymphoma, lymphocyte-rich Classical Hodgkin lymphoma, lymphocyte-rich Primary effusion lymphoma Mediastinal large B-cell lymphoma (C38.3) Thymic large B-cell lymphoma (C37.9) Splenic marginal zone B-cell lymphoma (C42.2) Splenic marginal zone lymphoma, NOS (C42.2) Splenic lymphoma with villous lymphocytes (C42.2) Marginal zone B-cell lymphoma, NOS Marginal zone lymphoma, NOS Mucosal-associated lymphoid tissue lymphoma MALT lymphoma Bronchial-associated lymphoid tissue lymphoma BALT lymphoma Skin-associated lymphoid tissue lymphoma SALT lymphoma Nodal marginal zone lymphoma Subcutaneous panniculitis-like T-cell lymphoma Hepatosplenic (gamma-delta) cell lymphoma Intestinal T-cell lymphoma Enteropathy type intestinal T-cell lymphoma Enteropathy associated T-cell lymphoma Primary cutaneous CD30+ T-cell lymphoproliferative disorder (C44._) Lymphomatoid papulosis (C44._) Primary cutaneous anaplastic large cell lymphoma (C44._) Primary cutaneous CD30+ large T-cell lymphoma (C44._) NK/T-cell lymphoma, nasal and nasal-type T/NK-cell lymphoma Precursor cell lymphoblastic lymphoma, NOS (see also M-9835/3) Precursor B-cell lymphoblastic lymphoma (see also M-9836/3) Precursor T-cell lymphoblastic lymphoma (see also M-9837/3) Langerhans cell histiocytosis, NOS Langerhans cell granulomatosis Histiocytosis X, NOS [obs] Langerhans cell histiocytosis, unifocal Langerhans cell granulomatosis, unifocal Langerhans cell histiocytosis, mono-ostotic Eosinophilic granuloma 244 Appendix 1: New ICD-O, Third Edition, Codes 9753/1 9754/3 9755/3 9756/3 9757/3 9758/3 9769/1 9805/3 9831/1 9833/3 9834/3 9835/3 9836/3 9837/3 9871/3 ** 9872/3 ** 9873/3 ** Langerhans cell histiocytosis, multifocal Langerhans cell histiocytosis, poly-ostotic Hand-Schuller-Christian disease [obs] Langerhans cell histiocytosis, disseminated Langerhans cell histiocytosis, generalized Histiocytic sarcoma Langerhans cell sarcoma Interdigitating dendritic cell sarcoma Interdigitating cell sarcoma Dendritic cell sarcoma, NOS Follicular dendritic cell sarcoma Follicular dendritic cell tumor Immunoglobulin deposition disease Systemic light chain disease Primary amyloidosis Acute biphenotypic leukemia Acute mixed lineage leukemia Acute bilineal leukemia T-cell large granular lymphocytic leukemia T-cell large granular lymphocytosis NK-cell large granular lymphocytic leukemia Large granular lymphocytosis, NOS Prolymphocytic leukemia, B-cell type Prolymphocytic leukemia, T-cell type Precursor cell lymphoblastic leukemia, NOS (see also M-9727/3) Precursor cell lymphoblastic leukemia, not phenotyped Acute lymphoblastic leukemia, precursor-cell type Acute lymphoblastic leukemia-lymphoma, NOS FAB L1 [obs] Acute lymphoblastic leukemia, L2 type, NOS FAB L2 Precursor B-cell lymphoblastic leukemia (see also M-9728/3) Pro-B ALL Common precursor B ALL Pre-B ALL Pre-pre-B ALL Common ALL c-ALL Precursor T-cell lymphoblastic leukemia (see also M-9729/3) Pro-T ALL Pre-T ALL Cortical T ALL Mature T ALL Acute myeloid leukemia with abnormal marrow eosinophils (includes all variants) Acute myeloid leukemia, inv(16)(p13;q22) Acute myeloid leukemia, t(16;16)(p13;q11) Acute myeloid leukemia, CBF-beta/MYH11 Acute myelomonocytic leukemia with abnormal eosinophils FAB M4Eo Acute myeloid leukemia, minimal differentiation FAB M0 Acute myeloid leukemia without maturation FAB M1 245 Appendix 1: New ICD-O, Third Edition, Codes 9874/3 ** 9875/3 9876/3 9895/3 9896/3 9897/3 9920/3 9945/3 9946/3 9948/3 9963/3 9964/3 9985/3 9986/3 9987/3 Acute myeloid leukemia with maturation FAB M2, NOS Chronic myelogenous leukemia, BCR/ABL positive Chronic myelogenous leukemia, Philadelphia chromosome (Ph1) positive Chronic myelogenous leukemia, t(9;22)(q34;q11) Chronic granulocytic leukemia, Philadelphia chromosome (Ph1) positive Chronic granulocytic leukemia, t(9;22)(q34;q11) Chronic granulocytic leukemia, BCR/ABL Atypical chronic myeloid leukemia, BCR/ABL negative Atypical chronic myeloid leukemia, Philadelphia chromosome (Ph1) negative Acute myeloid leukemia with multilineage dysplasia (see also M-9984/3) Acute myeloid leukemia with prior myelodysplastic syndrome Acute myeloid leukemia without prior myelodysplastic syndrome Acute myeloid leukemia, t(8;21) (q22;q22) Acute myeloid leukemia, AML1(CBF-alpha)/ETO FAB M2, t(8;21)(q22;q22) FAB M2, AML1(CBF-alpha)/ETO Acute myeloid leukemia, 11q23 abnormalities Acute myeloid leukemia, MLL Therapy-related acute myeloid leukemia and myelodysplastic syndrome, NOS Therapy-related acute myeloid leukemia, alkylating agent related Therapy-related acute myeloid leukemia, epipodophyllotoxin-related Chronic myelomonocytic leukemia, Type I Chronic myelomonocytic leukemia, Type II Chronic myelomonocytic leukemia in transformation [obs] Juvenile myelomonocytic leukemia Juvenile chronic myelomonocytic leukemia Aggressive NK-cell leukemia Chronic neutrophilic leukemia Hypereosinophilic syndrome Chronic eosinophilic leukemia Refractory cytopenia with multilineage dysplasia Myelodysplastic syndrome with 5q deletion (5q–) syndrome Therapy-related myelodysplastic syndrome, NOS Therapy-related myelodysplastic syndrome, alkylating agent related Therapy-related myelodysplastic syndrome, epidopophyllotoxin-related 246 Appendix 2: New Morphology Terms and Synonyms APPENDIX 2: NEW MORPHOLOGY TERMS AND SYNONYMS (The following 4-digit morphology codes existed in ICD-O, Second Edition.) 8000/1 8033/3 8040/0 8040/1 8041/3 8045/3 8051/3 8052/2 8053/0 8060/0 8074/3 8075/3 8077/2 8082/3 8091/3 8092/3 8093/3 8102/3 8110/0 8110/3 8120/1 8120/2 8121/0 Unclassified tumor, borderline malignancy Sarcomatoid carcinoma Tumorlet, benign Tumorlet, NOS Small cell neuroendocrine carcinoma Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma Condylomatous carcinoma Warty carcinoma Papillary squamous cell carcinoma, non-invasive Papillary squamous cell carcinoma in situ Squamous cell papilloma, inverted Squamous papillomatosis Squamous cell carcinoma, sarcomatoid Squamous cell carcinoma, acantholytic Squamous intraepithelial neoplasia, grade III Vaginal intraepithelial neoplasia, grade III (C52._) Vulvar intraepithelial neoplasia, grade III (C51._) Anal intraepithelial neoplasia (C21.1) AIN III (C21.1) Lymphoepithelioma-like carcinoma Multifocal superficial basal cell carcinoma (C44._) Infiltrating basal cell carcinoma, NOS (C44._) Infiltrating basal cell carcinoma, non-sclerosing (C44._) Infiltrating basal cell carcinoma, sclerosing (C44._) Basal cell carcinoma, morpheic (C44._) Basal cell carcinoma, desmoplastic type (C44._) Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS Trichilemmocarcinoma (C44._) Trichilemmal carcinoma (C44._) Pilomatricoma, NOS (C44._) Pilomatricoma, malignant (C44._) Matrical carcinoma (C44._) Transitional cell papilloma, NOS Urothelial carcinoma in situ Sinonasal papilloma, NOS (C30.0, C31._) Sinonasal papilloma, exophytic (C30.0, C31._) Sinonasal papilloma, fungiform (C30.0, C31._) Transitional cell papilloma, inverted, benign Transitional papilloma, inverted, benign 247 Appendix 2: New Morphology Terms and Synonyms 8121/1 8121/3 8122/3 8130/1 8130/2 8130/3 8140/1 8150/0 8150/1 8152/1 8153/1 8153/3 8154/3 8155/3 8201/2 8201/3 8230/2 8230/3 8240/1 8240/3 8241/3 8244/3 8245/1 8247/3 8260/0 8260/3 8263/3 8290/0 8290/3 8313/1 8313/3 8330/1 8333/3 8350/3 8372/0 8380/1 8401/0 Transitional papilloma, inverted, NOS Schneiderian papilloma, inverted (C30.0, C31._) Columnar cell papilloma Cylindrical cell papilloma (C30.0, C31._) Oncocytic Schneiderian papilloma (C30.0, C31._) Cylindrical cell carcinoma (C30.0, C31._) Transitional cell carcinoma, sarcomatoid Papillary transitional cell neoplasm of low malignant potential (C67._) Papillary urothelial neoplasm of low malignant potential (C67._) Papillary transitional cell carcinoma, non-invasive (C67._) Papillary urothelial carcinoma, non-invasive (C67._) Papillary urothelial carcinoma (C67._) Atypical adenoma Islet cell adenomatosis (C25._) Islet cell tumor, NOS (C25._) Alpha cell tumor, NOS (C25._) Gastrin cell tumor Gastrin cell tumor, malignant Mixed acinar-endocrine carcinoma (C25._) Mixed ductal-endocrine carcinoma (C25._) Vipoma, malignant Ductal carcinoma in situ, cribriform type (C50._) Ductal carcinoma, cribriform type (C50._) Ductal carcinoma in situ, solid type (C50._) Intraductal carcinoma, solid type Solid carcinoma with mucin formation Solid adenocarcinoma with mucin formation Carcinoid tumor of uncertain malignant potential Typical carcinoid Enterochromaffin cell carcinoid EC cell carcinoid Serotonin producing carcinoid Mixed carcinoid-adenocarcinoma Tubular carcinoid Primary cutaneous neuroendocrine carcinoma (C44._) Glandular papilloma Papillary carcinoma of thyroid (C73.9) Papillary renal cell carcinoma (C64.9) Papillotubular adenocarcinoma Tubulopapillary adenocarcinoma Follicular adenoma, oxyphilic cell (C73.9) Follicular carcinoma, oxyphilic cell (C73.9) Clear cell adenofibroma of borderline malignancy (C56.9) Clear cell cystadenofibroma of borderline malignancy (C56.9) Clear cell adenocarcinofibroma (C56.9) Clear cell cystadenocarcinofibroma (C56.9) Atypical follicular adenoma (C73.9) Fetal adenocarcinoma Papillary carcinoma, diffuse sclerosing (C73.9) Pigmented adenoma (C74.0) Atypical proliferative endometrioid tumor (C56.9) Apocrine cystadenoma 248 Appendix 2: New Morphology Terms and Synonyms 8402/3 8403/3 8404/0 8405/0 8406/0 8407/3 8408/1 8408/3 8410/0 8441/0 8441/3 8442/1 8452/1 8452/3 8460/3 8461/3 8462/1 8470/1 8470/2 8472/1 8480/3 8500/2 8501/2 8503/2 8503/3 8520/2 8522/3 8560/0 8620/1 8620/3 8631/0 8631/1 8631/3 8641/0 8670/0 8670/3 8680/0 8690/1 Nodular hidradenoma, malignant (C44._) Hidradenocarcinoma (C44._) Malignant eccrine spiradenoma (C44._) Eccrine cystadenoma (C44._) Hidradenoma papilliferum Syringocystadenoma papilliferum Sclerosing sweat duct carcinoma (C44._) Syringomatous carcinoma (C44._) Microcystic adnexal carcinoma (C44._) Aggressive digital papillary adenoma (C44._) Eccrine papillary adenocarcinoma (C44._) Digital papillary adenocarcinoma (C44._) Sebaceous epithelioma (C44._) Serous microcystic adenoma Serous carcinoma, NOS Atypical proliferating serous tumor (C56.9) Solid pseudopapillary tumor (C25._) Solid and papillary epithelial neoplasm (C25._) Solid and cystic tumor (C25._) Solid pseudopapillary carcinoma (C25._) Micropapillary serous carcinoma (C56.9) Primary serous papillary carcinoma of peritoneum (C48.1) Serous papillary cystic tumor of borderline malignancy (C56.9) Atypical proliferative papillary serous tumor (C56.9) Mucinous cystic tumor with moderate dysplasia (C25._) Mucinous cystadenocarcinoma, non-invasive (C25._) Mucinous cystic tumor of borderline malignancy (C56.9) Atypical proliferative mucinous tumor (C56.9) Pseudomyxoma peritonei with unknown primary site (C80.9) Ductal carcinoma in situ, NOS (C50._) DCIS, NOS (C50._) Ductal intraepithelial neoplasia 3 (C50._) DIN 3 (C50._) Ductal carcinoma in situ, comedo type (C50._) DCIS, comedo type (C50._) Ductal carcinoma in situ, papillary (C50._) DCIS, papillary (C50._) Infiltrating papillary adenocarcinoma LCIS, NOS (C50._) Infiltrating lobular carcinoma and ductal carcinoma in situ (C50._) Mixed squamous cell and glandular papilloma Granulosa cell tumor, adult type (C56.9) Granulosa cell tumor, sarcomatoid (C56.9) Sertoli-Leydig cell tumor, well differentiated Sertoli-Leydig cell tumor of intermediate differentiation Sertoli-Leydig cell tumor, NOS Sertoli-Leydig cell tumor, poorly differentiated Sertoli-Leydig cell tumor, sarcomatoid Lipid-rich Sertoli cell tumor (C56.9) Steroid cell tumor, NOS Steroid cell tumor, malignant Paraganglioma, benign Jugulotympanic paraganglioma (C75.5) 249 Appendix 2: New Morphology Terms and Synonyms 8691/1 8700/0 8700/3 8711/3 8726/0 8745/3 8761/0 8761/1 8761/3 8770/0 8810/1 8824/1 8830/0 8832/0 8841/1 8850/1 8851/3 8857/3 8890/0 8893/0 8897/1 8901/3 8902/3 8905/0 8910/3 8930/3 8931/3 8932/0 8940/3 8963/3 8982/0 8982/3 9014/1 9014/3 9015/1 9015/3 Aorticopulmonary paraganglioma (C75.5) Adrenal medullary paraganglioma (C74.1) Adrenal medullary paraganglioma, malignant (C74.1) Glomus tumor, malignant Melanocytoma, NOS Desmoplastic melanoma, amelanotic (C44._) Small congenital nevus (C44._) Intermediate and giant congenital nevus (C44._) Malignant melanoma in congenital melanocytic nevus (C44._) Pigmented spindle cell nevus of Reed (C44._) Cellular fibroma (C56.9) Infantile myofibromatosis Benign fibrous histiocytoma Cutaneous histiocytoma, NOS (C44._) Aggressive angiomyxoma Atypical lipoma Superficial well differentated liposarcoma Well differentiated liposarcoma of superficial soft tissue Lipoma-like liposarcoma Sclerosing liposarcoma Inflammatory liposarcoma Fibroblastic liposarcoma Plexiform leiomyoma Lipoleiomyoma Symplastic leiomyoma Atypical leiomyoma Pleomorphic leiomyoma Smooth muscle tumor of uncertain malignant potential Pleomorphic rhabdomyosarcoma, adult type Mixed embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma Genital rhabdomyoma (C51._, C52.9) Embryonal rhabdomyosarcoma, pleomorphic Endometrial stromal sarcoma, high grade (C54.1) Endometrial stromal sarcoma, low grade (C54.1) Atypical polypoid adenomyoma Malignant chondroid syringoma (C44._) Malignant rhabdoid tumor Rhabdoid tumor, NOS Myoepithelial adenoma Malignant myoepithelioma Myoepithelial carcinoma Serous adenofibroma of borderline malignancy (C56.9) Serous cystadenofibroma of borderline malignancy (C56.9) Serous adenocarcinofibroma (C56.9) Malignant serous adenofibroma (C56.9) Serous cystadenocarcinofibroma (C56.9) Malignant serous cystadenofibroma (C56.9) Mucinous adenofibroma of borderline malignancy (C56.9) Mucinous cystadenofibroma of borderline malignancy (C56.9) Mucinous adenocarcinofibroma (C56.9) Malignant mucinous adenofibroma (C56.9) Mucinous cystadenocarcinofibroma (C56.9) Malignant mucinous cystadenofibroma (C56.9) 250 Appendix 2: New Morphology Terms and Synonyms 9020/1 9041/3 9051/3 9052/0 9055/0 9062/3 9064/2 9071/3 9080/3 9084/3 9085/3 9110/1 9130/1 9160/0 9161/0 9174/1 9185/3 9221/3 9270/3 9271/0 9274/0 9290/3 9362/3 9364/3 9382/3 9383/1 9390/1 9390/3 9391/3 9400/3 9423/3 9442/1 9470/3 9471/3 9473/3 Phyllodes tumor, borderline (C50._) Synovial sarcoma, monophasic fibrous Spindled mesothelioma Sarcomatoid mesothelioma Desmoplastic mesothelioma Well differentiated papillary mesothelioma, benign Mesothelial papilloma Multicystic mesothelioma, benign Cystic mesothelioma, benign (C48._) Seminoma with high mitotic index (C62._) Intratubular malignant germ cells (C62._) Intratubular germ cell neoplasia (C62._) Hepatoid yolk sac tumor Immature teratoma, malignant Dermoid cyst with secondary tumor Mixed teratoma and seminoma Wolffian duct tumor Kaposiform hemangioendothelioma Giant cell angiofibroma Cellular angiofibroma Acquired tufted hemangioma Lymphangioleiomyomatosis Round cell osteosarcoma (C40._, C41._) Periosteal chondrosarcoma (C40._, C41._) Primary intraosseous carcinoma Ameloblastic fibrodentinoma Cemento-ossifying fibroma Ameloblastic fibrodentinosarcoma Ameloblastic fibro-odontosarcoma Mixed pineal tumor (C75.3) Mixed pineocytoma-pineoblastoma (C75.3) Pineal parenchymal tumor of intermediate differentiation (C75.3) Transitional pineal tumor (C75.3) Peripheral primitive neuroectodermal tumor, NOS PPNET Anaplastic oligoastrocytoma (C71._) Mixed subependymoma-ependymoma (C71._) Atypical choroid plexus papilloma (C71.5) Choroid plexus carcinoma (C71.5) Cellular ependymoma (C71._) Clear cell ependymoma (C71._) Tanycytic ependymoma (C71._) Diffuse astrocytoma (C71._) Astrocytoma, low grade (C71._) Diffuse astrocytoma, low grade (C71._) Polar spongioblastoma (C71._) Gliofibroma (C71._) Melanotic medulloblastoma (C71.6) Desmoplastic nodular medulloblastoma (C71.6) PNET, NOS Central primitive neuroectodermal tumor, NOS (C71._) CPNET (C71._) Supratentorial PNET (C71._) 251 Appendix 2: New Morphology Terms and Synonyms 9500/3 9501/0 9501/3 9502/0 9505/3 9506/1 9510/0 9521/3 9530/0 9530/3 9538/1 9538/3 9539/1 9540/3 9560/0 9561/3 9591/3 9652/3 9653/3 9654/3 9655/3 9663/3 9664/3 9665/3 9667/3 9670/3 9673/3 Central neuroblastoma (C71._) Diktyoma, benign (C69._) Diktyoma, malignant (C69._) Teratoid medulloepithelioma, benign (C69.4) Ganglioglioma, anaplastic Central neurocytoma Cerebellar liponeurocytoma Lipomatous medulloblastoma (C71.6) Neurolipocytoma (C71.6) Medullocytoma (C71.6) Retinocytoma (C69.2) Olfactory neurocytoma (C30.0) Microcystic meningioma Secretory meningioma Lymphoplasmacyte-rich meningioma Metaplastic meningioma Meningioma, anaplastic Clear cell meningioma Chordoid meningioma Rhabdoid meningioma Atypical meningioma Malignant peripheral nerve sheath tumor MPNST, NOS MPNST with glandular differentiation Epithelioid MPNST MPNST with mesenchymal differentiation Melanotic MPNST Melanotic psammomatous MPNST Melanotic schwannoma Plexiform schwannoma Cellular schwannoma Degenerated schwannoma Ancient schwannoma Psammomatous schwannoma Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation MPNST with rhabdomyoblastic differentiation B cell lymphoma, NOS Classical Hodgkin lymphoma, mixed cellularity, NOS Classical Hodgkin lymphoma, lymphocyte depletion, NOS Classical Hodgkin lymphoma, lymphocyte depletion, diffuse fibrosis Classical Hodgkin lymphoma, lymphocyte depletion, reticular Classical Hodgkin lymphoma, nodular sclerosis, NOS Classical Hodgkin lymphoma, nodular sclerosis, cellular phase Hodgkin lymphoma, nodular sclerosis, grade 1 Classical Hodgkin lymphoma, nodular sclerosis, grade 1 Hodgkin lymphoma, nodular sclerosis, grade 2 Classical Hodgkin lymphoma, nodular sclerosis, grade 2 Malignant lymphoma, small B lymphocytic, NOS (see also M-9823/3) Malignant lymphoma, small lymphocytic, NOS Malignant lymphoma, small cell diffuse Mantle cell lymphoma 252 Appendix 2: New Morphology Terms and Synonyms 9680/3 9684/3 9687/3 9690/3 9691/3 9695/3 9698/3 9700/3 9702/3 9709/3 9714/3 9731/3 9762/3 9765/1 9801/3 9823/3 9826/3 9827/3 9840/3 9860/3 9861/3 9866/3 9867/3 Malignant lymphoma, large B-cell, diffuse, centroblastic, NOS Intravascular large B-cell lymphoma (C49.9) Intravascular B-cell lymphoma Angiotropic lymphoma T-cell rich large B-cell lymphoma Histiocyte-rich large B-cell lymphoma T-cell rich/histiocyte-rich large B-cell lymphoma Anaplastic large B-cell lymphoma Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS Plasmablastic lymphoma Burkitt-like lymphoma Follicular lymphoma, NOS (see also M-9675/3) Malignant lymphoma, follicle center, follicular Malignant lymphoma, follicle center, NOS Follicular lymphoma, grade 2 Follicular lymphoma, grade 1 Follicular lymphoma, grade 3 Pagetoid reticulosis Mature T-cell lymphoma, NOS T-cell lymphoma, NOS Peripheral T-cell lymphoma, large cell Cutaneous T-cell lymphoma, NOS (C44._) Anaplastic large cell lymphoma, T cell and Null cell type Anaplastic large cell lymphoma, NOS Anaplastic large cell lymphoma, CD30+ Plasmacytoma of bone (C40._, C41._) Heavy chain disease, NOS Mu heavy chain disease Monoclonal gammopathy of undetermined significance MGUS Stem cell leukemia B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (see also M-9670/3) Chronic lymphocytic leukemia, B-cell type (includes all variants of BCLL) Burkitt cell leukemia (see also M-9687/3) B-ALL [obs] FAB L3 [obs] Acute lymphoblastic leukemia, mature B-cell type Adult T-cell leukemia/lymphoma (HTLV-1 positive) Includes all variants Acute myeloid leukemia, M6 type Acute erythroid leukemia M6A M6B FAB M6 AML M6 Non-lymphocytic leukemia, NOS Acute myeloid leukemia, NOS (FAB or WHO type not specified) (see also M-9930/3) Acute non-lymphocytic leukemia Acute promyelocytic leukemia, t(15;17)(q22;q11-12) Acute promyelocytic leukemia, PML/RAR-alpha Acute myeloid leukemia, t(15;17)(q22;q11-12) Acute myeloid leukemia, PML/RAR-alpha FAB M3 (includes all variants) FAB M4 253 Appendix 2: New Morphology Terms and Synonyms 9870/3 9891/3 9910/3 9930/3 9931/3 9940/3 9950/3 9961/3 9982/3 9983/3 9984/3 Acute basophilic leukemia FAB M5 (includes all variants) FAB M7 Myeloid sarcoma (see also M-9861/3) Acute panmyelosis with myelofibrosis (C42.1) Acute myelosclerosis Malignant myelosclerosis [obs] Hairy cell leukemia variant Proliferative polycythemia Myelofibrosis as a result of myeloproliferative disease Chronic idiopathic myelofibrosis Agnogenic myeloid metaplasia Refractory anemia with ringed sideroblasts RARS RAEB RAEB I RAEB II RAEB-T 254 Appendix 3: Terms That Changed Morphology Code APPENDIX 3: TERMS THAT CHANGED MORPHOLOGY CODE ICDO, Second Edition 8241/1 8241/1 8400/0 8402/0 8510/3 8510/3 8511/3 8580/3 8724/0 8724/0 8803/3 8832/0 8890/0 8930/3 9126/0 9190/3 9190/3 9190/3 9422/3 9443/3 9481/3 9490/0 9536/0 9592/3 9592/3 9593/3 9593/3 9593/3 9593/3 9594/3 9595/3 9657/3 9657/3 9658/3 9660/3 9660/3 9666/3 9672/3 9672/3 9672/3 9672/3 9674/3 9676/3 9676/3 9677/3 Term as it appears in ICD-O, Third Edition Carcinoid tumor, argentaffin, NOS Argentaffinoma, NOS [obs] Nodular hidradenoma (C44._) Eccrine poroma (C44._) Parafollicular cell carcinoma (C73.9) C cell carcinoma (C73.9) Medullary carcinoma with amyloid stroma (C73.9) Thymic carcinoma (C37.9) Fibrous papule of nose (C44.3) Involuting nevus (C44._) Askin tumor Histiocytoma, NOS Myofibroma Stromal sarcoma, NOS Histiocytoid hemangioma Parosteal osteosarcoma (C40._, C41._) Juxtacortical osteosarcoma (C40._, C41._) Periosteal osteosarcoma (C40._, C41._) Spongioblastoma, NOS (C71._) [obs] Primitive polar spongioblastoma (C71._) [obs] Monstrocellular sarcoma (C71._) [obs] Gangliocytoma Hemangiopericytic meningioma (C70._) [obs] Lymphosarcoma, NOS [obs] Lymphosarcoma, diffuse [obs] Reticulum cell sarcoma, NOS [obs] Reticulum cell sarcoma, diffuse [obs] Reticulosarcoma, NOS [obs] Reticulosarcoma, diffuse [obs] Microglioma (C71._) [obs] Malignant lymphoma, diffuse, NOS Hodgkin disease, lymphocyte predominance, NOS [obs] Hodgkin disease, lymphocytic-histiocytic predominance [obs] Hodgkin disease, lymphocyte predominance, diffuse [obs] Hodgkin paragranuloma, NOS [obs] Hodgkin paragranuloma, nodular [obs] Hodgkin disease, nodular sclerosis, mixed cellularity Malignant lymphoma, small cleaved cell, diffuse [obs] Malignant lymphoma, lymphocytic, poorly differentiated, diffuse [obs] Malignant lymphoma, small cleaved cell, NOS [obs] Malignant lymphoma, cleaved cell, NOS [obs] Malignant lymphoma, centrocytic [obs] Malignant lymphoma, centroblastic-centrocytic, diffuse [obs] Malignant lymphoma, centroblastic-centrocytic, NOS [obs] Malignant lymphomatous polyposis [obs] 255 ICD-O, Third Edition 8240/1 8240/1 8402/0 8409/0 8345/3 8345/3 8345/3 8586/3 9160/0 9160/0 9365/3 8831/0 8824/0 8935/3 9125/0 9192/3 9192/3 9193/3 9421/1 9423/3 9441/3 9492/0 9150/1 9591/3 9591/3 9591/3 9591/3 9591/3 9591/3 9590/3 9591/3 9651/3 9651/3 9651/3 9659/3 9659/3 9665/3 9591/3 9591/3 9591/3 9591/3 9673/3 9675/3 9675/3 9673/3 Appendix 3: Terms That Changed Morphology Code ICD-O, Second Edition 9681/3 9681/3 9681/3 9682/3 9682/3 9682/3 9682/3 9683/3 9683/3 9685/3 9685/3 9685/3 9686/3 9686/3 9686/3 9688/3 * 9692/3 9693/3 9694/3 9696/3 9697/3 9703/3 9704/3 9704/3 9706/3 9707/3 9710/3 * 9711/3 9712/3 9713/3 9713/3 9713/3 9713/3 9715/3 * 9715/3 * 9720/3 9720/3 9722/3 9722/3 9722/3 9723/3 9731/3 9763/3 9763/3 9802/3 9803/3 9804/3 Term as it appears in ICD-O, Third Edition Malignant lymphoma, large cell, cleaved, NOS Malignant lymphoma, large cell, cleaved, diffuse Malignant lymphoma, large cleaved cell, NOS Malignant lymphoma, large cell, noncleaved, diffuse Malignant lymphoma, large cell, noncleaved, NOS Malignant lymphoma, noncleaved, diffuse, NOS Malignant lymphoma, noncleaved, NOS Malignant lymphoma, centroblastic, NOS Malignant lymphoma, centroblastic, diffuse Malignant lymphoma, lymphoblastic (see also M-9821/3) Malignant lymphoma, convoluted cell [obs] Lymphoblastoma [obs] Malignant lymphoma, small cell, noncleaved, diffuse [obs] Malignant lymphoma, undifferentiated cell, non-Burkitt [obs] Malignant lymphoma, undifferentiated cell type, NOS [obs] T-cell rich large B-cell lymphoma Malignant lymphoma, centroblastic-centrocytic, follicular Malignant lymphoma, lymphocytic, well differentiated, nodular [obs] Malignant lymphoma, lymphocytic, intermediate differentiation, nodular [obs] Malignant lymphoma, lymphocytic, poorly differentiated, nodular [obs] Malignant lymphoma, centroblastic, follicular T-zone lymphoma Lymphoepithelioid lymphoma Lennert lymphoma Peripheral T-cell lymphoma, pleomorphic small cell Peripheral T-cell lymphoma, pleomorphic medium and large cell Marginal zone lymphoma, NOS Monocytoid B-cell lymphoma Angioendotheliomatosis Angiocentric T-cell lymphoma [obs] Malignant reticulosis, NOS [obs] Malignant midline reticulosis [obs] Polymorphic reticulosis [obs] Mucosal-associated lymphoid tissue lymphoma MALT lymphoma Malignant histiocytosis Histiocytic medullary reticulosis [obs] Letterer-Siwe disease Acute progressive histiocytosis X Nonlipid reticuloendotheliosis [obs] True histiocytic lymphoma [obs] Plasmacytoma, extramedullary (not occurring in bone) Gamma heavy chain disease Franklin disease Subacute leukemia, NOS [obs] Chronic leukemia, NOS [obs] Aleukemic leukemia, NOS [obs] 256 ICD-O, Third Edition 9680/3 9680/3 9680/3 9680/3 9680/3 9680/3 9680/3 9680/3 9680/3 9727/3 9727/3 9727/3 9591/3 9591/3 9591/3 9680/3 9690/3 9698/3 9591/3 9695/3 9698/3 9702/3 9702/3 9702/3 9702/3 9702/3 9699/3 9699/3 9680/3 9719/3 9719/3 9719/3 9719/3 9699/3 9699/3 9750/3 9750/3 9754/3 9754/3 9754/3 9755/3 9734/3 9762/3 9762/3 9800/3 9800/3 9800/3 Appendix 3: Terms That Changed Morphology Code ICD-O, Second Edition 9821/3 9821/3 9821/3 9821/3 9821/3 ** 9822/3 9822/3 9822/3 9824/3 9824/3 9824/3 9825/3 9828/3 ** 9828/3 ** 9830/3 9830/3 9841/3 9841/3 9841/3 9842/3 9850/3 9862/3 9862/3 9862/3 9864/3 9864/3 9864/3 9868/3 9880/3 9890/3 9892/3 9893/3 9894/3 9900/3 9932/3 9941/3 9960/1 9981/1 Term as it appears in ICD-O, Third Edition Acute lymphocytic leukemia Acute lymphoid leukemia Acute lymphatic leukemia Lymphoblastic leukemia, NOS FAB L1 Subacute lymphoid leukemia [obs] Subacute lymphocytic leukemia [obs] Subacute lymphatic leukemia [obs] Aleukemic lymphoid leukemia [obs] Aleukemic lymphocytic leukemia [obs] Aleukemic lymphatic leukemia [obs] Prolymphocytic leukemia, NOS Acute lymphoblastic leukemia, L2 type, NOS FAB L2 Plasma cell leukemia (C42.1) Plasmacytic leukemia (C42.1) Acute erythremia [obs] Di Guglielmo disease [obs] Acute erythremic myelosis [obs] Chronic erythremia [obs] Lymphosarcoma cell leukemia [obs] Subacute myeloid leukemia [obs] Subacute granulocytic leukemia [obs] Subacute myelogenous leukemia [obs] Aleukemic myeloid leukemia [obs] Aleukemic granulocytic leukemia [obs] Aleukemic myelogenous leukemia [obs] Chronic myelomonocytic leukemia, NOS Eosinophilic leukemia Monocytic leukemia, NOS Subacute monocytic leukemia [obs] Chronic monocytic leukemia [obs] Aleukemic monocytic leukemia [obs] Mast cell leukemia (C42.1) Acute myelofibrosis Leukemic reticuloendotheliosis Myeloproliferative disease, NOS Refractory anemia without sideroblasts * code used in United States only (1995-2000) **code used in United States only (1998-2000) 257 ICD-O, Third Edition 9835/3 9835/3 9835/3 9835/3 9835/3 9820/3 9820/3 9820/3 9820/3 9820/3 9820/3 9832/3 9835/3 9835/3 9733/3 9733/3 9840/3 9840/3 9840/3 9950/3 9820/3 9860/3 9860/3 9860/3 9860/3 9860/3 9860/3 9945/3 9860/3 9860/3 9860/3 9860/3 9860/3 9742/3 9931/3 9940/3 9975/1 9980/3 Appendix 4: Terms That Changed from Tumor Like Lesions to Neoplasms Appendix 5: Terms Deleted from ICD-0, Third Edition APPENDIX 4: TERMS THAT CHANGED FROM TUMOR-LIKE LESIONS TO NEOPLASMS M---------M---------M---------M---------M---------M---------- Term as it appears in ICD-O, Third Edition Reticulohistiocytoma Lymphomatoid papulosis (C44._) Giant cell tumor of tendon sheath Histiocytosis X, NOS Eosinophilic granuloma Hand-Schuller-Christian disease APPENDIX 5: TERMS DELETED FROM ICD-O, THIRD EDITION ICD-O, Second Edition 8077/2 8092/3 8152/0 8332/3 8810/0 8851/0 8851/0 9053/0 9190/3 9190/3 9382/3 9531/0 9560/0 9722/3 Intraepithelial neoplasia, grade III of cervix, vulva and vagina (replaced with Squamous intraepithelial neoplasia, grade III; Cervical intraepithelial neoplasia, grade III; Vaginal intraepithelial neoplasia, grade III; Vulvar intraepithelial neoplasia, grade III) Basal cell carcinoma, morphea (replaced with Basal cell carcinoma, morpheic) Alpha cell adenoma (replaced with 8152/1 Alpha cell tumor, NOS) Wuchernde Struma Langhans (C73.9) [obs] (deleted) Fibroma durum (deleted) Fibroma molle (deleted) Soft fibroma (deleted) Mesothelioma, biphasic, benign (deleted) Juxtacortical osteogenic sarcoma (C40._, C41._) [obs] (replaced with 9192/3 Juxtacortical osteosarcoma) Periosteal osteogenic sarcoma (C40._, C41._) (replaced with 9193/3 Periosteal osteosarcoma) Mixed oligoastrocytoma (replaced with Oligoastrocytoma) Meningotheliomatous meningioma (replaced with Meningothelial meningioma) Melanocytic schwannoma (replaced with Melanotic schwannoma) Acute differentiated progressive histiocytosis (replaced with 9754/3 Acute progressive histiocytosis X) 258 ICD-O, Third Edition 8831/0 9718/3 9252/0 9751/1 9752/1 9753/1 Appendix 6: Terms That Changed Behavior Code APPENDIX 6: TERMS THAT CHANGED BEHAVIOR CODE Terms Changing from Borderline to Malignant ICD-O, Second Edition 8931/1 8931/1 8931/1 8931/1 8931/1 9393/1 9538/1 9950/1 9950/1 9960/1 9960/1 9961/1 9961/1 9961/1 9962/1 9962/1 9962/1 9962/1 9980/1 9981/1 9982/1 9982/1 9983/1 9984/1 9989/1 9989/1 9989/1 Term as it appears in ICD-O, Third Edition Endometrial stromal sarcoma, low grade (C54.1) Endolymphatic stromal myosis (C54.1) Endometrial stromatosis (C54.1) Stromal endometriosis (C54.1) Stromal myosis, NOS (C54.1) Papillary ependymoma (C71._) Papillary meningioma Polycythemia vera Polycythemia rubra vera Chronic myeloproliferative disease, NOS Chronic myeloproliferative disorder Myelosclerosis with myeloid metaplasia Megakaryocytic myelosclerosis Myelofibrosis with myeloid metaplasia Idiopathic thrombocythemia Essential thrombocythemia Essential hemorrhagic thrombocythemia Idiopathic hemorrhagic thrombocythemia Refractory anemia, NOS Refractory anemia without sideroblasts Refractory anemia with sideroblasts Refractory anemia with ringed sideroblasts Refractory anemia with excess blasts Refractory anemia with excess blasts in transformation Myelodysplastic syndrome, NOS Preleukemia Preleukemic syndrome 259 ICD-O, Third Edition 8931/3 8931/3 8931/3 8931/3 8931/3 9393/3 9538/3 9950/3 9950/3 9960/3 9960/3 9961/3 9961/3 9961/3 9962/3 9962/3 9962/3 9962/3 9980/3 9980/3 9982/3 9982/3 9983/3 9984/3 9989/3 9989/3 9989/3 Appendix 6: Terms That Changed Behavior Code Terms Changing from Malignant to Borderline ICD-O, Second Edition 8442/3 8442/3 8451/3 8462/3 8462/3 8462/3 8462/3 8472/3 8472/3 8472/3 8472/3 8473/3 8473/3 8473/3 9421/3 9421/3 9421/3 9422/3 Term as it appears in ICD-O, Third Edition Serous cystadenoma, borderline malignancy (C56.9) Serous tumor, NOS, of low malignant potential (C56.9) Papillary cystadenoma, borderline malignancy (C56.9) Serous papillary cystic tumor of borderline malignancy (C56.9) Papillary serous cystadenoma, borderline malignancy (C56.9) Papillary serous tumor of low malignant potential (C56.9) Atypical proliferative papillary serous tumor (C56.9) Mucinous cystic tumor of borderline malignancy (C56.9) Mucinous cystadenoma, borderline malignancy (C56.9) Pseudomucinous cystadenoma, borderline malignancy (C56.9) Mucinous tumor, NOS, of low malignant potential (C56.9) Papillary mucinous cystadenoma, borderline malignancy (C56.9) Papillary pseudomucinous cystadenoma, borderline malignancy (C56.9) Papillary mucinous tumor of low malignant potential (C56.9) Pilocytic astrocytoma (C71._) Piloid astrocytoma (C71._) Juvenile astrocytoma (C71._) Spongioblastoma, NOS (C71._) [obs] ICD-O, Third Edition 8442/1 8442/1 8451/1 8462/1 8462/1 8462/1 8462/1 8472/1 8472/1 8472/1 8472/1 8473/1 8473/1 8473/1 9421/1 9421/1 9421/1 9421/1 Terms Changing from Benign to Borderline ICD-O, Second Edition 8120/0 8152/0 8580/0 8640/0 8640/0 8640/0 8640/0 8640/0 9506/0 Term as it appears in ICD-O, Third Edition Transitional cell papilloma, NOS Glucagonoma, NOS (C25._) Thymoma, NOS (C37.9) Sertoli cell tumor, NOS Pick tubular adenoma Sertoli cell adenoma Tubular androblastoma, NOS Testicular adenoma Neurocytoma ICD-O, Third Edition 8120/1 8152/1 8580/1 8640/1 8640/1 8640/1 8640/1 8640/1 9506/1 Terms Changing From Borderline to Benign ICD-O, Second Edition 8261/1 8261/1 8361/1 8361/1 8823/1 9080/1 Term as it appears in ICD-O, Third Edition Villous adenoma, NOS Villous papilloma Juxtaglomerular tumor (C64.9) Reninoma (C64.9) Desmoplastic fibroma Mature teratoma 260 ICD-O, Third Edition 8261/0 8261/0 8361/0 8361/0 8823/0 9080/0 Suomen Syöpäyhdistyksen julkaisuja nro 75 Helsinki 2008 ISBN 978 952 5815 00 9
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