docâGround Stateâ Adult Stem Cells in Regenerative Medicine, Disease
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Department of Microbiology & Immunology Programme Seminar Series … May 2015 Day / Date / Time th Monday 4 May 2015 1pm “Ground State” Adult Stem Cells in Regenerative Medicine, Disease Modeling, and Cancer Therapeutics Discovery Profs dfad f Venue Professor Frank McKeon National University of Singapore (NUS), Department of Microbiology, Seminar Room @ 5 Science Drive 2, Blk MD4A, Level 2, Singapore 117545 Genome Institute of Singapore MultiClonal Therapeutics, Inc. Convener Prof Nicholas Gascoigne ALL ARE WELCOME Abstract Induced pluripotent stem cells (iPSCs) dominate prospective efforts in regenerative medicine and disease modeling despite organic features that limit their utility. In contrast, resident adult stem cells, especially those of regenerative columnar epithelia such as the gastrointestinal tract, liver, pancreas, and kidney, have been largely ignored because of technical barriers that prevent their cloning and propagation. The lab has now developed robust methods for cloning the adult stem cells from these tissues in their most immature, ground state. This technology is beginning to unravel basic properties of the adult stem cells including their unlimited expansion ability and epigenetic memory of both lineage commitment and in some cases chronic disease states. Moreover, ground state stem cells show a remarkable ability to assemble complex structures similar to mature tissues without external guidance. These properties, combined with the ease of generating stem cells from endoscopic biopsies, suggest that patient-specific, ground state stem cells represent a viable alternative to iPSCs in regenerative medicine and disease modeling. In addition to ground state stem cells of regenerative epithelia, this technology has been applied to stem cells of highly aggressive epithelial cancers such as those of the esophagus, stomach, pancreas, liver, and ovary. From “libraries” of such cancer stem cells from individual cases the immense heterogeneity of these tumors can be reconstructed from a genomics analysis of the individual constituent clones. From the therapeutic standpoint, these libraries enable the discovery of intrinsically (pre-therapy) resistant clones that most likely mount recurrent disease following standard-of-care chemotherapy. Such approaches have tremendous potential for tailoring cancer therapies to each patient. About our speaker Visit our website @ www.med.nus.edu.sg/mbio for more upcoming seminars Frank McKEON and Wa XIAN jointly oversee a highly interactive group devoted to the cloning of stem cells of regenerative tissues and using advanced technologies to understand the genetics of their self-renewal, commitment, and differentiation. They have a strong interest in determining pathways by which these stem cells might contribute to regenerative medicine especially for lung and liver, and pancreatic diseases. In addition, they have a strong interest in precursors of cancers- in particular early lesions that lead to high-grade ovarian cancers as well as in the origins of intestinal metaplasias which precede esophageal, gastric, and pancreatic adenocarcinoma. Frank McKeon was born in New Haven, Connecticut, and was an undergraduate at Pomona College. He did his doctoral and postdoctoral studies in Biochemistry and Biophysics with Prof. Marc Kirschner at the University of California, San Francisco. He worked at Harvard University for more than twenty years and joined the Genome Institute of Singapore as a Senior Group leader in 2008. He spent three years at Jackson Laboratory for Genomic Medicine as director of Quantitative Cell Biology before his present position shared between MultiClonal Therapeutics and the Genome Institute of Singapore. He has worked in several areas of cell biology including nuclear lamin dynamics, the spindle assembly checkpoint monitoring chromosome segregation, the role of NF-AT transcription factors in T cell activation, and mouse models of the p53 homologs p63 and p73.
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Market Overview – Regenerative Medicine Market Shares, Strategies And Forecasts to 2023: Credence Research
Credence Research has recently issued a new market assessment report titled “Regenerative Medicine – Growth, Future Prospects and Competitive Analysis, 2016 – 2022”. The global Regenerative Medicine Market study provides a comprehensive view of the ongoing and future phases of the Regenerative Medicine industry based on parameters such as major commercial events, research initiatives, government guidelines, market drivers, restraints and opportunities and detailed industry segmentation and regional distribution.
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Based on geographic/regional distribution the global Regenerative Medicine Market is studied for key regional markets focusing on the respective geographic trends and statistics, and thereby delivering market size and forecast values. The Regenerative Medicine Market based on geographic classification is studied for North America, Europe, Asia-Pacific, Latin America, and Middle East and Africa markets. Among these, the North America, Europe and Asia-Pacific Regenerative Medicine Market is studied for top country-level markets. The Regenerative Medicine industry in each individual country market is studied based on parameters such as per capita income, population, gross domestic product (GDP), status of infrastructure, purchasing power parity, etc. Technology development, industry concentration, end-user preference, and similar such grounds are also considered while estimating the market for Regenerative Medicine. The market estimates are provided for the period 2014-2022, along with corresponding compounded annual growth rates (CAGRs) for the forecast period 2016-2022.
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This report on Regenerative Medicine Market also offers competition assessment tools such as market positioning of key players, attractive investment proposition, and Porter’s Five Forces model to give the readers a view of the competitive scenario of the Regenerative Medicine Market. The Regenerative Medicine Market report is concluded with company profiles chapter. This section highlights major information about the key players engaged in development, manufacture, distribution and sale of Regenerative Medicine in the international markets.
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Major extracts from the Table of Content of Regenerative Medicine Market, 2016-2022 report:
Regenerative Medicine Market Dynamics – Drivers, Challenges, Opportunities
Regenerative Medicine Market Size and Forecast for the Period 2014-2022
Regenerative Medicine Market CAGR for the Period 2016-2022
Regenerative Medicine Market Competitive Analysis, by Key Players
Regenerative Medicine Market: Attractive Investment Proposition, by Geography
Regenerative Medicine Market: Key Commercial Events
Regenerative Medicine Market: Future Prospects (upcoming product approvals)
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Global Regenerative Medicine Market
Regenerative medicine is a category of research in tissue engineering and molecular biology which deals with the method for human cells, tissues and organs reco nstruction to reactivate normal body function. The regenerative medicine repairs the defective cells and tissues. Regenerative medicine treats the basic cause of disease, injuries and genetic conditions. Regenerative medicine gives complete treatment of the abnormality or disease as compared to the symptomatic treatments. Regenerative medicine is a treatment technique which works in three approaches which ensure the complete eradication of the injury of the cell, tissue or organ. There are stem cells and non-stem cell (somatic) therapies which includes taking cells from healthy body organ in the body and applying these cells to the damaged area after expanding these cells in cell culture.