CV - Lund University Diabetes Centre

Transcription

CV - Lund University Diabetes Centre
CURRICULUM VITAE – CHARLOTTE LING (690420-4986)
A. CONTACT INFORMATION
Unit of Epigenetics and Diabetes, Department of Clinical Sciences, Faculty of Medicine, Lund University Diabetes
Centre, Jan Waldenströms gata 35, SE 205 02 Malmö, Sweden;
Tel: +46 (0) 40 391213; Fax: +46 (0) 40-391222;
E-mail: [email protected]
Website: (http://www.ludc.med.lu.se/research-units/epigenetics-and-diabetes/)
B. EDUCATION
2009
2003-2006
2002
1994
C. APPOINTMENTS
Present positions:
2015 Previous positions
2013-2014
2011-2013
2009-2010
2007-2009
2003-2006
1997-2002
1995-1996
1994-1995
Associate Professor (Docent) Medicine, Lund University, Sweden
Postdoctoral studies, Department of Clinical Sciences, Lund University, Malmö, Sweden
PhD, Endocrinology/Medicine, University of Gothenburg, Sweden; Title: Prolactin receptor
expression and prolactin-mediated effects in adipose tissue. Supervisor: Prof Håkan Billig
Masters in chemical engineering, LTH, Lund University, Sweden
100% research
Professor in Diabetes Research, Lund University, Sweden
Lecturer in Epigenetics, Lund University, Sweden
Senior researcher at the Swedish Research Council, 100% research for six years
Associate Professor, Dept. of Clinical Sciences in Malmö, Lund University (research career
award from the Swedish Research Council), 100% research
Assistant Professor, Dept. of Clinical Sciences in Malmö, Lund University (research career
award from the Swedish Research Council), 100% research
Postdoctoral fellow, Dept. of Clinical Sciences, Lund University, Malmö, Sweden
PhD student, Dept of Physiology, University of Gothenburg, Sweden
Sales representative, Progen Industries (Biotechnology), Brisbane, Australia
Process engineer, Medowlea foods, Brisbane, Australia
D. PARENTAL LEAVE
During 2001-2002, 2004-2005, 2006-2007 and shorter periods during 2007-2013
E. COMISSIONS OF TRUST
2012-present
Member of the Innovation board at Lund University Diabetes Centre (LUDC)
2012, 2015
Member of evaluation committees at the Swedish Research Council
2010-present
Member of the board and a PI of the Lund University Diabetes Centre (LUDC)
2010-2013
Member of the board of the Dept. of Clinical Sciences, Lund University
2010-present
Member of the strategic research area, Exodiab (http://www.exodiab.se/)
2009-present
Member of the PhD–examiner board and/or opponent of 6 PhD theses
2008-2011
Member of the election committee for the board of the medical faculty at Lund University
2003-2006
Member of the steering group of the Diabetes Program at Lund University, chairman 2006
F. PRIZES, HONOURS AND AWARDS
2013
Medeon award
2011
2011
2006
2006 & 2007
2003
Five-year excellence grant, Novo Nordisk Foundation
Six-year research career award from the Swedish Research Council
Four-year research career award from the Swedish Research Council
Hains award from the Medical faculty, Lund University
Swegene Postdoctoral fellowship award from the Wallenberg foundation
G. RESEARCH AND TEACHING ABROAD
2013
Opponent on PhD-thesis by M Lundh, University of Copenhagen, Denmark
2011
Opponent on PhD-thesis by M Friedrichsen, University of Copenhagen, Denmark
2008-present
Teaching at several PhD courses in Denmark
2007
Research visit at Fudan University, Shanghai, China
2001-present
Invited speaker at ~50 international conferences including e.g. American Diabetes
Association, Keystone, International Diabetes Foundation, Endocrine Society and the
European Association for the Study of Diabetes-Study Group on Genetics of Diabetes
1999
Research visit at Garvan institute of medical research, Sydney, Australia
H. REFEREE/REVIEWER/EDITOR
Reviewer for more than 15 international journals since 2003
External evaluator of grants for the Swedish Research Council, The Welcome trust, The Swiss Research Council and
Diabetes UK since 2005
Associate Editor for Clinical Epigenetics
I. SUPERVISION OF DOCTORAL STUDENTS
Previous PhD-students (year of dissertation): As main supervisor 1) Dr Tina Rönn (2010), 2) Dr Anders H. Olsson
(2012), 3) Dr Siri Malmgren (2012); as co-supervisor 4) Dr Louise Nilsson (2009), 5) Dr Cecilia Nagorny (2012).
Current PhD-students in my group: As main supervisor 6) Beatrice Yang, 7) Elin Hall, 8) Tasnim Dayeh, 9) Peter
Volkov, 10) Mahboubeh Daneshpajooh, 11) Alexander Perfilyev, 12) Cajsa Davegårdh
POSTDOCTORAL RESEARCHERS/VISITING SCIENTISTS
Previous members: 1) Dr Marloes Dekker Nitert (2008-2011), 2) Dr Jie Wen (2008), 3) Dr Louise Nilsson (20092012), 4) Dr Sofia Andersson (2012-2013), 5) Dr Annika Lundstig (2012-2013), 6) Dr Anders Olsson (2012-2014)
Currently active in my group: 7) Dr Tina Rönn (2010- ), 8) Dr Emma Nilsson (2011- ), 9) Dr Karl Bacos (2012- ), 10)
Dr Madhu Bysani (2014- )
J. PEDAGOGICAL TRAINING
Higher academic pedagogical training (10 weeks) and a leadership course (Future research leaders)
K. EXPERIENCE FROM COMMUNICATING RESULTS
Vast experience from oral and written communication with funding agencies, end users, patients, health care
professionals and peers i.e. in 2013 a press-release from Ling´s group on how exercise changes the human
epigenome (T Rönn et al Plos Genetics 2013) received worldwide media attention (5th place on the AlphaGalileo list of
most down-loaded press releases in the world).
L. CURRENT RESEARCH FUNDING
Receive funding from Swedish Research Council, Regional Research Council (ALF), European Union, Novo Nordisk
foundation Excellence grant, Söderberg foundation, Påhlsson foundation, Diabetes foundation and EFSD-Lilly.
Approximately 4.5 million SEK yearly funding.
TEN SELECTED PUBLICATIONS – CHARLOTTE LING
BIBLIOMETRICAL ANALYSIS (Web of Science)
Ten publications selected from a total of 82 peer-reviewed articles
71 peer reviewed original articles, 11 peer reviewed review articles, 7 book chapters
Total number of citations: >4300 times
H-index = 29
M-index= 1.9
A full publication list is found at http://www.ludc.med.lu.se/research-units/epigenetics-and-diabetes/groupmembers/head/.
I have chosen the following list of 10 publications since they reflect both my work in diabetes and epigenetic research
as well as my interest in bioinformatics and statistical analysis of genome-wide human data.
I am now established as a world leading expert in diabetes epigenetics and am frequently invited to give keynote
lectures and participate in research collaborations.
In 2013 a press-release from my group on how exercise changes the human epigenome (publication 3 below)
received worldwide media attention (5th place on the AlphaGalileo list of most down-loaded press releases in the
world).
1. Elin Hall, Petr Volkov, Tasnim Dayeh, Jonathan Lou S. Esguerra, Sofia Salö, Lena Eliasson, Tina Rönn, Karl
Bacos and Charlotte Ling
Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels
and insulin secretion in human pancreatic islets
Genome Biology, 2014 Dec 3;15(12):522. Impact factor: 10.5
Citations: 2
This is the first study identifying genome-wide epigenetic differences in human pancreatic islets from male
compared with female donors. These epigenetic differences in human islets contribute to differential gene
expression, microRNA levels and insulin secretion between males and females. I was responsible for the
study, designed the study, analyzed data and wrote manuscript.
2. Anders H Olsson, Petr Volkov, Karl Bacos, Tasnim Dayeh, Elin Hall, Emma A Nilsson, Claes Ladenvall, Tina Rönn
and Charlotte Ling
Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin
Secretion in Human Pancreatic Islets.
PLoS Genetics, 2014 Nov 6;10(11):e1004735. Impact factor: 8.9 Citations: 6
This is a benchmark study from my group. We demonstrate a strong interaction between genetics and
epigenetics that contribute to altered function in human pancreatic islets and potentially the risk for diabetes.
3. Emma Nilsson, Per Anders Jansson, Alexander Perfilyev, Petr Volkov, Maria Pedersen, Maria K Svensson,
Pernille Poulsen, Rasmus Ribel-Madsen, Nancy L Pedersen, Joao Fadista, Tina Rönn, Bente Klarlund-Pedersen,
Camilla Scheele, Allan Vaag and Charlotte Ling
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose
tissue from subjects with type 2 diabetes.
Diabetes, 2014 Sep 63; 9: 2962-2976
Impact factor: 9.1
Citations: 17
This is the first study analyzing DNA methylation genome-wide in human adipose tissue from subjects with
T2D and non-diabetic controls as well as in monozygotic twins discordant for T2D. We identified numerous
epigenetic alterations in subjects with T2D. I was responsible for the study, designed the study, analyzed data
and wrote manuscript.
4. Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma Nilsson, Anders H. Olsson, Clare L. Kirkpatrick, Claes
Wollheim, Lena Eliasson, Tina Rönn, Karl Bacos and Charlotte Ling
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors
identifies candidate genes that influence insulin secretion
PLoS Genetics, 2014 Mar 6;10(3):e1004160
Impact factor: 8.9
Citations: 39
This is another benchmark study in my group. It is the first study analyzing DNA methylation genome-wide in
human pancreatic islets from donors with T2D and non-diabetic controls. Here, we identified epigenetic
alterations in ~800 genes in diabetic islets. I was responsible for the study, designed the study, analyzed data
and wrote manuscript.
5. Tina Rönn, Petr Volkov, Cajsa Davegård, Tasnim Dayeh, Elin Hall, Targ Elgzyri, Åsa Tornberg, Marloes DekkerNitert, Karl-Fredrik Eriksson, Helena Jones, Leif Groop and Charlotte Ling
A six months exercise intervention influences the epigenetic pattern in human adipose tissue
PLoS Genetics 2013 Jun;9(6):e1003572.
Impact factor: 8.9
Citations: 62
This is the first study analyzing DNA methylation genome-wide in human adipose tissue before and after
regular exercise. We found that a six month exercise intervention altered the DNA methylation pattern of ~1/3
of all genes in human adipose tissue. I was responsible for the study, designed the study, analyzed data and
revised the ms. Here, we developed a bioinformatics pipe-line to analyse genome-wide DNA methylation data.
This study received enormous media attention i.e. NY times and The Economist.
6. Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, Emma Nilsson, Beatrice T. Yang,
Stefan Lang, Hemang Parikh, Ylva Wessman, Holger Weishaupt, Joanne Attema, Mia Ländin, Nils Wierup, Peter
Almgren, Per-Anders Jansson, Tina Rönn, Ola Hansson, Karl-Fredrik Eriksson, Leif Groop and Charlotte Ling
Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle from First Degree Relatives of Patients
with Type 2 Diabetes
Diabetes 2012 Dec;61(12):3322-32
Impact factor: 9.1
Citations: 47
This is the first study analyzing DNA methylation genome-wide in human skeletal muscle before and after
regular exercise. We found that a six month exercise intervention altered the DNA methylation pattern of
~3000 genes in skeletal muscle of sedentary middle aged men. I was responsible for the study, designed the
study, analyzed data and wrote the ms. Here, we developed a bioinformatics and statistical pipe-line to
analyse data from a tiling array.
7. Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir V. Sharoyko, Claes Ladenvall, Olga Kotova,
Erwin Reiling, Tina Rönn, Hemang Parikh, Jalal Taneera, Johan G Eriksson, Metodi D Metodiev, Nils-Göran
Larsson, Alexander Balhuizen, Holger Luthman, Alena Stančáková, Johanna Kuusisto, Markku Laakso, Pernille
Poulsen, Allan Vaag, Leif Groop, Valeriya Lyssenko, Hindrik Mulder* and Charlotte Ling* *Equal contribution
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2
diabetes.
Cell Metabolism 2011 Jan 5;13(1):80-91.
Impact factor: 17.8
Citations: 25
This study shows how mitochondrial dysfunction due to genetic variation influences insulin secretion and risk
for T2D. I was responsible for the study (together with H Mulder), designed the study, analyzed data, wrote
and revised the ms. This study included analysis of genome-wide SNP data.
8. Charlotte Ling, Silvia Del Guerra, Roberto Lupi, Tina Rönn, Charlotte Granhall, Holger Luthman, Pierro Marchetti ,
Leif Groop and Stefano Del Prato.
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
Diabetologia 2008 51(4):615-22.
Impact factor: 6.8
Citations: 149
This is the first study to identify altered DNA methylation levels in human pancreatic islets from subjects with
T2D compared with non-diabetic controls. I designed the study, designed the study, analyzed data, wrote and
revised the ms
9. Charlotte Ling, Pernille Poulsen, Stina Simonsson, Tina Rönn, Johan Holmkvist, Peter Almgren, Emma Nilsson,
Per Hagert, Amanda G. Mabey, Peter Nilsson, Allan Vaag and Leif Groop
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human
skeletal muscle.
The Journal of Clinical Investigation, 2007 117(11): 3427-35. Impact factor: 14.4
Citations: 81
This study shows how combinations of genetic (SNPs), epigenetic (DNA methylation) and non-genetic (age)
factors interact to affect gene expression of a candidate gene forT2D and metabolic function in human
skeletal muscle. Designed the study, analyzed data, wrote and revised the manuscript
10. Charlotte Ling*, Pernille Poulsen*, Emma Carlsson, Martin Ridderstråle, Peter Almgren, Henning Beck-Nielsen,
Leif Groop, Allan Vaag. * Both authors have contributed equally.
Multiple environmental and genetic factors influence skeletal muscle PGC-1 and PGC-1 gene expression in
twins.
The Journal of Clinical Investigation, 2004; 114:1518-26. Impact factor: 14.4
Citations: 185
This study shows how combinations of genetic and non-genetic factors affect gene expression of a candidate
gene for T2D and metabolic function in human skeletal muscle. Designed the study, designed the study,
analyzed data, wrote and revised the ms