IMC LIV AGBPfinalReport Final Mar20 2
Transcription
IMC LIV AGBPfinalReport Final Mar20 2
From Research to Ranch Alberta Bovine Genomics Program January 2006 — December 2010 Table of Contents Message from the Program Leader Message from the Program Leader 01 It is with great pleasure that I write this foreword for the Alberta Bovine Genomics Program’s (ABGP) final report. I leave having established the ABGP as one of the world’s premier livestock genomics programs. The years 2006–10 were watershed years in genomics science, and the ABGP played a pivotal part in developing the next generation of technologies and applying them in livestock species. The first bovine genome sequence was published in 2009. The pig genome was sequenced in 2010. The sheep genome neared completion soon after that. ABGP scientists played key roles in all of these. Background02 Vision, Goals, Research Areas04 Commercial Benefits of Genomics05 Major Achievements ü Recognized as an International Leader 06 ü Delivered Marker Technologies 08 ü Ensured the Transfer of Technology 10 ü Established Lasting Partnerships 12 ü Attracted High Levels of Funding 14 ü Trained the Next Generation of Scientists and Users 16 Lead Scientists18 A Look Forward: Message from Livestock Gentec’s CEO 20 The ABGP’s objective was to provide tools for industry. The development of a genotyping tool, which is now the standard for dairy breeding internationally, was based on ABGP work. So were gene marker tests that are now used as genetic predictors for a number of traits in beef cattle. The ABGP provided a fertile training program for the next generation of scientists. PhD and Master’s students found positions in industry, government and laboratories around the world. The reputation of Alberta-based science has been strengthened, and the group at the University of Alberta is now recognized as a top training option for students globally. I trust that what has now become a broader livestock genomics program will continue to prosper and gain the support necessary to keep Alberta at the forefront of the field. Principal Funders: Professor Stephen Moore Program Leader, Alberta Bovine Genomics Program Centre Director, Centre for Animal Science Queensland Alliance for Agriculture and Food Innovation University of Queensland Program Host: Alberta Bovine Genomics Program, January 2006 — December 2010 01 From Research to Ranch Background What Is Genomics? Generally, genomics is the science that studies an organism’s entire genome—that is, its DNA sequence. It analyzes the Alberta has invested in and built a world-class genomics research and innovation system. It has a high-quality breeding herd, low-cost production practices and superior management practices. It is already a major player in the North American meat industry. Canada is the world’s 3rd largest exporter of feed grain. It has robust animal health systems and identification protocols, and sound expertise in large-scale livestock production. Meat consumption in developing countries is expected to account for more than 80 percent of global growth in meat commodities over the next decade. The highest growth rates are projected for vegetable oils and livestock products. However, other countries are developing their livestock industries, and this is putting pressure on Canada’s ability to be competitive. “I see the science of genomics as the salvation for most of the major issues facing society today…To me, this is the big picture reason why Canada must allow this animal genomics research initiative to go forward, and in so doing regain its lost competitive advantage in agri-food.” relationship between genetics and traits, and uses the data to answer scientific questions and solve practical problems. Specifically, the data provide information on individual animals. This information could be identity, pedigree, performance potential, or the animal’s response to nutrition or preventative health measures. Producers can use that information to breed selectively and improve their stock. John Webb, Director of Genetics and Science, Maple Leaf Foods Inc., June 2008 Genomics technologies have already helped the Canadian dairy industry make tremendous advances in breeding, yield and health. They are doing the same for other sectors of the livestock industry. About the Alberta Bovine Genomics Program The Alberta Bovine Genomics Program (ABGP) built on the research and international reputation established by Dr. Stephen Moore, Program Leader, in bovine genomics. The ABGP brought together a group of highly skilled scientists in genomics, genetics and bioinformatics, and addressed the need for better breeding and management technologies through cutting-edge research. The ABGP developed into a world-leading centre for genomics research and technology development, and pioneered the development of tests for genome-wide association studies in cattle. The success of the ABGP set the stage for Livestock Gentec, an Alberta Innovates Bio Solution Centre, created from the Program in 2010. Livestock Gentec extends the genomics scope to other species, and expands on existing technology transfer and industry collaboration efforts. 02 Alberta Bovine Genomics Program, January 2006 — December 2010 03 From Research to Ranch Vision and Goals Commercial Benefits of Genomics Vision For Producers • Lower costs. • 9-10 percent lower herd maintenance.1 • 20-40 percent estimated genetic gain.2 • 10-12 percent less feed used by animals that grow faster. (A genetic test to determine which animals have this trait would more than pay for itself.)1 Become Canada’s leading centre for bovine genomics. Goals ü Establish more collaborations based on existing international and national linkages, and recruit top talent to the Program. ü Deliver advanced genetic and genomics technologies to improve animal production and health and maintain Canada’s competitive advantage in the livestock industry. ü Become an international leader in bovine genomics research, development and technology transfer, focusing on advanced breeding and reproductive technologies. ü Create Alberta-based, spin-off companies. Research Areas Genomics focuses on identifying gene sequences and examining how these correlate to desired performance and economic traits. Applying this knowledge to breeding and production management strategies is vital to the long-term competitiveness of the Alberta beef industry. To this end, the ABGP targeted two key areas of research and development: • Faster genetic improvement. Even with the best conventional breeding and reproduction technologies, it still takes five years to rear a bull calf to sexual maturity and progeny-test its offspring. Using genomics tools could compress the entire cycle and have the first superior calves born in little more than a year. • Better animal health. Understanding genomics may lead to better vaccines and disease immunity, new gene-based targets for treatment, faster response times to new threats and the potential to breed healthier animals. “As livestock and aquaculture markets become increasingly competitive, breeders will require new means to improve their genetics.” Joachim Richert, CEO and Managing Director, DNA LandMarks (BASF) 1. Advanced Breeding Technologies: developing DNA marker tests and genetic indexes that will allow beef producers to select for desired performance traits, such as improved feed efficiency, carcass quality, health management and quality assurance. • Increased competitiveness. Other countries are already using genomics-based technologies to improve their livestock industries. For the Value Chain • Safer, healthier meat. Breeding for animals that respond better to vaccination, carry a lower burden of animal-to-human organisms and need fewer antibiotics improves safety throughout the food chain. 2. Structural Genomics: building the basis for continual improvement. This involves developing detailed genetic “road maps” of individual animals that are the core of the tools necessary for the ongoing development and application of selection strategies. Canadian Agri-Food Policy Institute, 2007 • Improved traceability. Genomic information and infrastructure can advance biosafety programs by tracing animals through their DNA. This will allow disease outbreaks or contamination in the food chain to be rapidly identified. 1 2 04 “Agriculture is the foundation on which the bio-economy is built. Countries which allow their agricultural base to deteriorate over the next 10 years will not be able to participate in the new wealth creation.” Agrifacts: Practical Information for Alberta’s Agriculture Industry. July 2006. Agdex 420/11-1. an Eenennaam et al, 2010. Value of DNA Information for Beef Bull Selection. 9th World Congress of Genetics Applied to V Livestock Production. Leipzig, Germany. Alberta Bovine Genomics Program, January 2006 — December 2010 05 From Research to Ranch Major Achievement — Recognized as an International Leader ABGP Research: Bovine Genome Sequencing Projects Several members of the ABGP research team played a leading International Collaborations and Research ABGP scientists took on leadership or contributing roles in international collaborations, such as • Bovine Genome Sequencing Project (see textbox) (multi-national). • Multiple and Candidate Gene Approaches to Evaluation and Improvement of Economically Relevant Traits in Cattle (USA, multi-site). • Genetic Identification Techniques to Improve Food Safety Recall of Ground Meat (Ireland). • Metabolic Analysis of the Rumen of Steers with Different Feed Efficiencies (USA). The ABGP recruited scientists from the international pool for its research program. In the opposite direction, a number of ABGP graduate students and post-doctoral fellows are now pursuing their careers abroad (see Trained the Next Generation of Scientists and Users). International Speaking Opportunities and Publications Over the term of the Program, AGBP scientists published 110 articles in international peer-reviewed journals and spoke frequently at international meetings. Key invited conference presentations include • 9th World Conference of Genetics Applied to Livestock Production, Leipzig, Germany, August 2010. ABGP scientists amply and impressively represented the ABGP with six presentations: • Genome-Wide Association Scan for Signals of Recent Selection in Angus Beef Cattle. • Efficient Nutrient Utilization and Its Relationship with Carcass and Meat Quality Traits—Is There a Trade Off? • Beef Tenderness QTL on BTA25 from a Whole Genome Scan with the Illumina Bovine SNP50 Beadchip. • Identification of Candidate Markers on BTA14 Affecting Conformation and Functional Traits in Canadian Holstein. • Genome-Wide Scan for Positional and Functional Candidate Genes Affecting Milk Production Traits in Canadian Holstein Cattle. • Joint Genome-Wide Gametic and Zygotic Linkage Disequilibria Explain the Distinct Domestication between Dairy and Beef Cattle Populations. • Joint Canada-Japan Meeting on Prion Disease, Tokyo, Japan, November, 2010. • 10th Agricultural Biotechnology International Conference, Saskatoon, Canada, September 2010. • PrioNet China-Canada Workshop on Prion Disease, Beijing, China, November 2009. • AgriVision 2009, Noordwijk, Netherlands, June 2009. 06 role in the Bovine Genome Sequencing Project consortium, an international initiative to sequence the entire bovine genome. Among them, Dr. Moore participated on the Steering Committee and the Scientific Advisory Committee. The ABGP led the Canadian effort with the Genome Sciences Centre in Vancouver. The consortium published its findings in two landmark research papers in the journal Science in 2009. The work secured the cover image and the headline, Livestock Decoded. These papers presented the genome structure of (western) cattle and a highdensity SNP survey that uncovered the genetic structure of the cattle breeds. The Canadian-led part of the Project produced 10,000 unique fulllength cDNA sequences that were crucial to the annotation of the genome sequence; and all library construction and sequencing was carried out in Canada. “I am excited about the evolution of genomics. These new technologies will reduce costs, increase our competitiveness, enhance meat quality and help feed the world’s growing population. Canadian producers will achieve significant improvements in genetic gain, in large part because of Livestock Gentec’s research to convert the knowledge gained from the Program into tools we can use to select animals.” Dr. David Chalack Partner, RockyMountain Holsteins Board Chair, Alberta Livestock and Meat Agency Alberta Bovine Genomics Program, January 2006 — December 2010 07 From Research to Ranch Major Achievement — Delivered Marker Technologies ABGP Research: The Bov50SNP Chip The Bov50SNP Chip is a tool for testing genetic merit in cattle that is widely used in the dairy industry and by commercial Canadian research under the Bovine Genome Sequencing Project (see International Collaborations) was key to developing commercially important technologies. Among these were high-density single nucleotide polymorphism (SNP) chips for genome-wide association studies in cattle. service and industry labs, and academic research labs around the world. The ABGP pioneered gene-mapping studies with a 3K chip, then with a 6K chip. A collaborative effort between the ABGP, the University of Missouri, the United States Department of Agriculture and Illumina further developed a 50K SNP chip (see textbox). Next-generation sequencing technologies, very high density SNP panels, the inexpensive 3K chip and strategies that allow researchers to build high-density genotypes from low-density information mean that affordable, breed-specific prediction equations are now possible for all cattle breeds. “Downstream technology directly resulting from the sequencing of the bovine genome includes the development of high density SNP chips. Dr. Moore’s group pioneered this work with the development of a 3K chip with other groups. The Bov50SNP chip revolutionized breeding in the dairy industry, and has had a cumulative annual benefit of $180M to the Candian dairy industry.” “A recent direction taken by Canadian Dairy Network is the priority placed on the application of genomics to increase the accuracy of the genetic evaluations in dairy cattle in Canada, starting in 2009.” Brian Van Doormaal, General Manager, Canadian Dairy Network, June 2008 Jacques P. Chesnais, Senior Geneticist, Semex Alliance 08 Alberta Bovine Genomics Program, January 2006 — December 2010 09 From Research to Ranch Major Achievement — Ensured the Transfer of Technology ABGP Research: A Few of the 35 Patent Applications • Genetic Markers Associated with Improved Milk Production Traits in Cattle. Forged Partnerships with Industry • Associations of SNPs and Haplotypes with Feed Intake and The ABGP forged close relationships with industry groups and producers along the value chain. Collaborations made testing across breeds possible and promoted feedback that focused the relevance of research to industry. Feed Efficiency in Beef Cattle. • DNA Polymorphisms as Molecular Markers in Cattle. • Association of SNPs in the CBRA2T1 and DECR1 Genes with All projects benefited from significant industry participation. Collaborators included Canadian Simmental, Limousin, Hereford and Gelbvieh associations, Beefbooster, Beef Improvement Opportunities, Canadian Dairy Network, L’Alliance Boviteq, Merial, Genus and Identigen (see Global Partnerships for a complete list). Performance and Carcass Merit of Beef Cattle. Evolved into Livestock Gentec and Its Subsidiaries AGBP evolved into Livestock Gentec—an Alberta Innovates Bio Solutions Centre that will continue to develop and capitalize on ABGP research innovations, inform industry of the benefits of genomics and train people to use the new technologies. Livestock Gentec established Delta Genomics, a national not-for-profit company in Edmonton, with support from Western Economic Diversification Canada. Delta Genomics offers a variety of services to the Albertan and Canadian livestock industry, as well as to the research community. These services include sample storage, DNA preparation and distribution, genomic analysis, data analysis and consultation. The company will also act as Livestock Gentec’s technology validation and commercialization body, and contribute to the adoption of new technologies. Canada Europe USA Converted Research into Patents and Licences for Industry ABGP work resulted in 33 active patents and 15 invention disclosures, captured in four exclusive licences with industry partners, including Merial Ltd. (a world-leading animal health company) and Genoa Biotechnology (a Brazil-based molecular genetics company). See textbox for more details. The patents were filed in major beef-breeding areas: Argentina, Australia, Brazil, Canada, Europe, Mexico, New Zealand and the USA. The technology provided the basis for the industry-leading Illumina Bov50SNP chip (see textbox on previous page) used by commercial service labs world-wide (such as DNA Landmarks, GeneSeek (now Neogen), CynerGene and SABiosciences/Qiagen). Mexico Brazil Australia Argentina New Zealand 10 Alberta Bovine Genomics Program, January 2006 — December 2010 11 From Research to Ranch Major Achievement Established Lasting Partnerships ABGP People: Links at the Personal Level The ABGP was fortunate to recruit internationally renowned experts, such as Heather Burrow (CEO, CRC Beef Australia, and animal scientist), Chris Warkup (CEO, Biosciences Knowledge Transfer Network, UK, meat scientist and Coordinator of European Commission SABRE FP6 project), and John Pollak (Director, USDA Meat Animal Research Center) to its International Scientific Edmonton • Agriculture Funding Consortium • Alberta Advanced Education and Technology • Alberta Agriculture Research Institute • Alberta Ingenuity Fund • Alberta Innovates Bio Solutions • Alberta Livestock and Meat Agency • Alberta Livestock Industry Development Fund • Alberta Prion Research Institute • Alberta Science and Research Authority • Western Economic Diversification Canada Advisory Board (see Program Leaders for the full list of Board members). Australia • Co-operative Research Centre for Beef Genetic Technologies Brazil • Genoa Biotecnologia SA England • Genus, plc Ireland • IdentiGEN Ltd. Saskatoon • Genome Prairie Vancouver • Genome British Columbia • PrioNet Canada 12 Calgary • Alberta Beef Producers • Alberta Cattle Commission • Beef Cattle Research Council • Beefbooster Inc. •C anada Alberta Beef Industry Development Fund • Canadian Cattlemen’s Association • Genome Alberta Scotland • KTN Biosciences • Roslin Institute Guelph • BIO—Beef Improvement Opportunities • Canadian Dairy Network • DairyGen Council • Semex Alliance Ottawa • Canada Foundation for Innovation • Natural Sciences and Engineering Research Council USA • Merial Ltd. • United States Department of Agriculture Saint-Hyacinthe • L’Alliance Boviteq Inc. Alberta Bovine Genomics Program, January 2006 — December 2010 13 From Research to Ranch Major Achievement — Attracted High Levels of Funding The ABGP was extraordinarily successful in attracting funding from federal, provincial and industry sources and, in addition to the $4.6 million of program funding from ALMA/AI Bio, obtained research grants that amounted to more than $27 million. Many of those grants were matched with industry cash and in-kind contributions. See the highlighted projects as examples. Federal Funding • Agriculture and Agri-Food Canada • Canada Foundation for Innovation • Genome Canada • Natural Sciences and Engineering Research Council of Canada • PrioNet Canada • Western Economic Diversification Canada Provincial Funding • Agricultural Adaptation Council • Agriculture Funding Consortium (Alberta Innovation and Science/Alberta Livestock Industry Development Fund) • Alberta Agricultural Research Institute • Alberta Ingenuity Fund • Alberta Innovates Bio Solutions • Alberta Livestock and Meat Agency • Alberta Prion Research Institute • Genome Alberta • Ontario Ministry of Agriculture, Food and Rural Affairs • Ontario Research and Development Industry Funding • Alberta Beef Producers • Alberta Milk • Beef Cattle Research Council • Beefbooster Inc. • Canadian Dairy Network • DairyGen • Genoa Biotechnologia SA • Genus, plc • L’Alliance Boviteq Inc. • Merial Ltd. • Ontario Cattlemen’s Association • Semex Alliance Funding: $1,040,000 AAFC/ALMA, $1.2 million industry Lead Scientists: John Basarab This project proposes to accelerate the adoption of genetic technology regarding residual feed intake (RFI) and tenderness in the beef cattle industry by testing 2,000-3,000 animals for RFI, tenderness and meat quality. The data collected will form one of the largest, upgradable databases of its kind from which gene marker and expected progeny differences (EPD) validation studies can be conducted to increase producer-level confidence in genetic improvement through progenytesting in industry populations. Following completion of the dataset, the validation and economic work can be accomplished. To this end, the University of Alberta and Alberta Agriculture and Rural Development have entered into an agreement with Merial to validate their commercial and precommercial markers for numerous growth, feed efficiency, and carcass and meat quality traits. Highlighted Project: Rumen Metagenomics Funding: $689,000 from ALMA, ALIDF, AARI, Alberta Beef Producers; $140,000 from NSERC Lead Scientists: Leluo Guan, Stephen Moore, Paul Stothard This on-going project aims to understand the impact of the interaction between rumen microbes and the host on feed-efficiency traits in cattle. So far, the research shows that certain species of bacteria and methanogens are only found in the rumens of feed-efficient cattle, and that these variations in microbial diversity contribute to higher dietary conversion and lower energy loss from methane emission. This suggests that rumen bacteria should be taken into account as part of the biological mechanisms influencing feed efficiency. Further findings suggest that the interaction between the host genotype and the environment has a strong impact on the relationship between rumen function and feed efficiency. Functional genomics studies of rumen microbial populations in beef cattle with different feed efficiencies and genotypes will be a powerful tool for explaining the molecular mechanisms of these relationships and identifying the microbial and host markers for feed efficiency under different feeding regimes. Highlighted Project: Beef Residual Feed Intake and Tenderness Funding: $483,000 from the Beef Cattle Research Council (BCRC); $422,623 from ALMA, ACAAF, Alberta Beef Producers, BCRC; $431,250 from BCRC, AAFC, Beef Cluster. Also funded by Ontario Ministry of Agriculture Food and Rural Affairs (OMAFRA), Ontario Cattlemen’s Association, Ontario Research Development, and Agriculture Adaptation Council (Ontario) Lead Scientists: Stephen Moore, Stephen Miller Total ALMA/AI Bio Program Funding: $4,634,496 Student and post doc salaries Other salaries and benefits Services Equipment Materials/supplies Travel/conferences 14 Highlighted Project: Phenomic Gap This was a sequence of projects aiming to establish marker panels for beef cattle that industry could use as breeding tools. The Illumina bovine 50SNP chip was used to correlate feed efficiency and tenderness with genetic markers from the University of Guelph breeding herd, the University of Alberta Kinsella herd, and the Alberta Agriculture Phenomic Gap population. In collaboration with Beef CRC in Australia and the US Department of Agriculture Meat Animal Research Station, additional useful SNPs were identified and are being exploited in further, multi-million dollar national and international Livestock Gentec-led collaborations that will provide the extensive dataset needed for commercial panels that are applicable to a wide range of breeds. Alberta Bovine Genomics Program, January 2006 — December 2010 15 From Research to Ranch Major Achievement — Trained the Next Generation of Scientists and Users Under the ABGP’s guidance, eight graduate students completed their degrees; 18 post-doctoral fellows and research associates, and 16 technologists and research assistants obtained training that prepared them for careers in livestock genomics. These people are pursuing successful careers in • Industry • Merial Ltd. • Pfizer • Beefbooster, Inc. • Canadian Hereford Association • GeneSeek • Monsanto • Academia and Research • University of Alberta School of Medicine, Canada • Hospital for Sick Children, Toronto, Canada • University of Missouri, USA • Washington State University, USA • BC Cancer Agency, Canada • International Livestock Research Institute, Nairobi, Kenya • Sichuan Agricultural University, China • National Institute of Agribiological Sciences, Tsukuba, Japan • Government • Canadian Food Inspection Agency Seventeen more ABGP students are working to complete their graduate degrees. Dr. Elisa Marques Elisa Marques completed her BSc in Honours Microbiology and PhD in Animal Genetics from the University of Alberta, where her research focused on identifying genetic markers for several economically relevant traits in beef and dairy cattle. After graduation, Marques was awarded the Alberta Ingenuity scholarship and became an R&D Scientist for Beefbooster, a beef cattle seedstock company in Calgary, Alberta, where she acquired valuable skills in the application of genomics to improve beef cattle genetics. Most recently, she became the Market Development Manager for GeneSeek, the world leader in DNA testing for agrigenomics in Lincoln, Nebraska. In this role, she is responsible for driving the uptake of genomics technology throughout North and Latin America. 16 Dr. Denis Fidalis Mujibi Denis Fidalis Mujibi completed a BSc at Egerton University and a Master’s at Kenyatta University, both in Kenya. He did the project work for his Master’s at the International Livestock Research Institute (ILRI) in Kenya, where he became interested in the work Stephen Moore was doing at the University of Alberta. Moore agreed to supervise Mujibi for his PhD. After completing his studies, Mujibi worked for Merial Igenity, a multi-national animal health company in Duluth, Georgia, where he examined ways of obtaining genomic tools to help producers better manage, breed and select animals for desired traits. Now back at the ILRI as a geneticist, Mujibi’s work focuses on improving the characterization of animal genetic resources and the application of genomic tools to characterize smallholder livestock systems in developing countries. Dr. Guoqing Tang Guoqing Tang graduated from the Sichuan Agricultural University, China, with a PhD in 2006. He spent 2008-09 at the University of Alberta as a postdoctoral fellow, working under the auspices of the ABGP. He has since returned to the Sichuan Agricultural University as Associate Professor of animal genetics and breeding. His research focuses on quantitative genetics and statistic genomics in swine science. For example, how to optimize the relative weight of QTL and polygene in a mixed model, how to apply genomic selection in swine breeding, how to optimize some key factors in applying genomic selection in swine breeding, how to detect causative mutation of complex traits using genome-wide markers in swine science, and how to develop evaluation model of genomic selection in swine breeding. Alberta Bovine Genomics Program, January 2006 — December 2010 “Livestock genomics is moving incredibly quickly. The progress made in the last 12 months would have been regarded as science fiction last year… The future opportunities are immense. We are committed to the development and application of genomics in the bovine industry and I believe Canada has a fantastic opportunity to take a world lead for all farmed species.” Jacques P. Chesnais, Senior Geneticist, Semex Alliance 17 From Research to Ranch Lead Scientists 1 6 2 3 7 8 4 5 9 The core team consisted of 1. Stephen Moore (Leader, ABGP) University of Alberta 2. Graham Plastow (Director, ABGP), University of Alberta 3. Stephen Miller (animal genetics/genomics, Director of Industry Adoption, Livestock Gentec), University of Guelph 4. John Basarab (beef genomics), Alberta Agriculture and Rural Development 5. Carolyn Fitzsimmons (molecular genetics), University of Alberta 6. Leluo Guan (functional genomics), University of Alberta 7. Changxi Li (molecular genetics), University of Alberta 8. Paul Stothard (bioinformatics), University of Alberta 9. Zhiquan Wang (quantitative /statistical genetics), University of Alberta Drs. Wang, Guan and Stothard were recruited in 2006 to assemble a well rounded team to carry out the ABGP’s objectives. Dr. Plastow joined in 2007, and contributed extensive commercialization and industry experience as well as scientific expertise in livestock genomics. He succeeded Dr. Moore as CEO of Livestock Gentec in Fall 2011. Dr. Fitzsimmons joined in 2009, and contributed additional molecular genetics and expertise in epigenics. Drs. Guan, Li, Stothard and Wang were the core scientists and devoted 100 percent of their time to the project. • Dr. Paul Stothard is developing a world-class bioinformatics infrastructure for the livestock industries at the University of Alberta. His research focuses on the development of novel software tools for managing and analyzing biological data, on the characterization of rumen bacterial DNA sequences and their relationship to feed efficiency, and on the development of new methods for predicting animal traits. 18 • Dr. Leluo Guan was a key contributor to the international Bovine Genome Sequencing Project. Her research in bovine functional genomics involves establishing links between genomics results and economically important traits in livestock species. She has extensive experience in developing research approaches to study bovine functional genomics, and an excellent track record in commercializing research results. • Dr. Changxi Li’s research activities include identifying and characterizing genes for economically important traits in beef cattle, and implementing DNA markers in beef cattle genetic evaluation and breeding programs. His current projects focus on identifying SNP markers associated with growth, feed efficiency, carcass merit and fatty acid composition in beef cattle, and using genomics tools to improve beef productivity and quality. • Dr. Zhiquan Wang is interested in enhancing our understanding of genetic variations in animal populations and exploiting this to increase the production efficiency and quality of livestock. His research includes the development of quantitative genetic theories, statistical methodologies for investigating the associations between genomic and phenotypic variations, identification and mapping candidate genes and quantitative trait loci (QTL). International Advisory Board • Erasmus Okine (Chair), University of Alberta • John Buckley, Quarter Circle X Ranch, and Chair, Beefbooster, Alberta • Heather Burrow, CEO, CRC Beef Australia, and animal scientist • Brett Campbell, Executive Vice President, Canadian Beef Breeds Council • Cornelia Kreplin, Director, Alberta Agriculture and Rural Development • Dr. Stephen Miller, Director, Centre for the Genetic Improvement of Livestock, University of Guelph • Stephen Morgan-Jones, Director General, Science Partnerships Directorate, Agriculture and Agri-Food Canada • Diane Panrucker, Alberta Beef Producers • John Pollak, Director, USDA Meat Animal Research Center • Julie Stitt, Industry Liaison, FoodLogiQ, Canada (representing Canadian Beef Breeds Council) • Chris Warkup, CEO, Genesis Faraday Partnership, UK, meat scientist and Coordinator, EU SABRE FP6 project Alberta Bovine Genomics Program, January 2006 — December 2010 19 From Research to Ranch A Look Forward: Message from Livestock Gentec’s CEO As I write, the Alberta Innovates Livestock Gentec centre is rounding out its second year of operation. As the ABGP’s natural successor, “Gentec” has made fast progress thanks to the ABGP’s strong research base and record of success. In addition to Alberta Innovates funding and with continued support for key positions from the Alberta Livestock and Meat Agency (ALMA), Alberta Agriculture and Rural Development, and Agriculture and Agri-Food Canada, we have grown Gentec’s knowledge translation and technology transfer capacity. As Gentec enters its third year, we see continued success on the research front, exemplified by winning two important Genome Canada grants. With additional support from ALMA, other partners and industry, these grants represent more than $20 million of funding for applied research in the livestock sector in Canada. The projects supported by these grants allow Gentec to take a leading role in collaborations with partners from US, Europe and Australasia. With these elements in place, Gentec is an exciting place to be as we work to develop tools that will help Canada’s livestock industries remain competitive and well placed to help feed the world’s growing population and its increasing demand for the healthiest and highest-quality meat products. We could not have done this without the catalyst provided by the ABGP, and the collaborations and networks put together by Dr. Stephen Moore and the senior research team. Dr. Graham Plastow CEO, Livestock Gentec 20 Alberta Bovine Genomics Program, January 2006 — December 2010 21 Livestock Gentec 1400 College Plaza 8215 112 Street Edmonton, AB T6G 2C8 780 492 2383 www.livestockgentec.com