Final Program ready for
Transcription
Final Program ready for
Table of Contents Scientific Organizers and Scientific Advisory Board ........................................... 5 Welcoming Addresses ........................................................................................ 6 Program at a Glance ........................................................................................... 8 Oral Presentations Tuesday, April 26 ..................................................................................... 10 Wednesday, April 27................................................................................ 11 Thursday, April 28................................................................................... 18 Friday, April 29 ........................................................................................ 25 Biosecurity Lounge ........................................................................................... 28 Poster Presentations......................................................................................... 30 General Information .......................................................................................... 58 3 4 Medical Biodefense Conference 2016 Scientific Organizers and Scientific Advisory Board Conference Chair Professor Dr. Lothar Zöller, Colonel (MC) Director Bundeswehr Institute of Microbiology Neuherbergstrasse 11, 80937 Munich, Germany e-mail: [email protected] Phone: +49-(0)89-992692-3980 Conference Secretary PD Dr. Gregor Grass Bundeswehr Institute of Microbiology Neuherbergstrasse 11, 80937 Munich, Germany e-mail: [email protected] Phone: +49-(0)89-992692-2806 Scientific Advisory Board ♦ Professor Dr. Sergei Bankoul (CHE) Medical NBC (CBRN) Defense of the Swiss Armed Forces ♦ Professor Dr. Martin Beer (DEU) Friedrich-Loeffler-Institute ♦ Professor Dr. Dr. Andreas Hensel (DEU) ♦ ♦ ♦ ♦ ♦ ♦ ♦ Federal Institute for Risk Assessment Professor Dr. Detlev H. Krüger (DEU) Charité Institute of Virology Dr. Robert Massung (USA) Centers for Disease Control and Prevention Dr. Bärbel Niederwöhrmeier (DEU) Bundeswehr Research Institute for Protective Technologies and CBRN Protection Professor Dr. Georg Peters (DEU) Münster University Institute of Microbiology Professor Dr. Lars Schaade (DEU) Robert-Koch-Institute Professor Dr. Gerd Sutter (DEU) Ludwig-Maximilians-University Munich Dr. Gilles Vergnaud (FRA) ENSTA ParisTech Université Paris-Saclay 5 Welcoming Addresses Dear Colleagues, On behalf of the Bundeswehr Institute of Microbiology, I cordially welcome you to the 15th Medical Biodefense Conference. This year we have decided to move the meeting from its traditional place in October to April and we hope very much that you will like Munich not only at Oktoberfest time but in early spring as well. Although challenges related to a legacy of Asbestospollution in some of our buildings have made the available space at our Bundeswehr Medical Academy even tighter, we were still able to adhere to this venue in order to keep the conference fee at a reasonable level. This time we received 287 contributions for oral or poster sessions, which is a new record, and I hope that the scientific program compiled under the auspices of our Scientific Advisory Committee will meet your expectations. Most of the sessions will feature at least one keynote lecture on a topic of special interest. We have once again scheduled many parallel sessions with a lot of speedy 15-minute presentations. Nevertheless, a number of submissions had to be converted from oral to poster presentations. We apologize for not being able to accommodate all your preferences, but I can say we did our best. As usual, we will be happy to honor three posters with poster awards. We thank the German Society for Military Medicine and Pharmacy and Altona Diagnostics for making this possible. The Medical Biodefense Conference 2016 scientific program addresses the whole bandwidth of medical biodefense topics, from political to scientific, from theoretical to practical, from mass casualties to casuistics. With regard to the recent Ebola outbreak in West Africa, time has come to assess the lessons learned and to improve our preparedness for future outbreaks. Consequently, the Ebola topic will be addressed in the Opening Session, but also by many other presenters throughout the program. During the conference, you will also have an opportunity to learn more about the recent developments in the Zika virus epidemic in the Americas, and get updates on MERS, plague, anthrax, tick-borne encephalitis and many more topics. I also highly recommend the Interactive Case Report Workshop to all physicians and medical students amongst us. Let me finally draw your attention to a session featuring the activities of the German Partnership Program for Excellence in Biological and Health Security as well as invite you to our Biosecurity Lounge, where you can personally meet the project partners. Finally, don´t miss to enjoy Munich in springtime. It is beautiful! For the Oktoberfest enthusiasts among you, I should not fail to mention that Munich is celebrating its 52nd Frühlingsfest (Spring festival, April 15 - May 1) this year on the famous Theresienwiese, the home of the Oktoberfest. The Frühlingsfest is very much like the Oktoberfest, but on a smaller, less crazy scale. Anyway, I hope that you will enjoy your stay in Munich and wish you an informative and pleasant time at the Medical Biodefense Conference 2016. Sincerely, Prof. Dr. L. Zöller, Colonel (MC) Conference Chair Bundeswehr Institute of Microbiology 6 Medical Biodefense Conference 2016 Dear Conference Participants, Fellow Soldiers, Colleagues, Ladies and Gentlemen, I warmly welcome you to the 15th Medical Biodefense Conference organized by the Bundeswehr Institute of Microbiology in cooperation with the German Society for Military Medicine and Pharmacy here in Munich. Particularly with an eye on the current developments worldwide, goals like "networking", "sharing experience" and "multinational cooperation" are no longer just "en vogue" but actually - as we all know – are without any alternative for operations to be successful. Summarizing boldly and simply the mission of medical services in general, we can say: The focus of our activities is on the health of our patients - in each and every respect! The efficiency of any healthcare system, among other things, depends on the expertise of a wide array of highly qualified specialists who, by cooperating professionally, achieve the best possible outcome and benefit. As multifaceted as our capabilities, as different, yet, are the often unpredictable challenges we are facing nowadays. Think, for instance, of the Ebola hemorrhagic fever virus outbreak in Africa or most recently the fast spread of Zika virus, which caused the World Health Organization to declare a global health emergency. The challenges will not diminish. We, therefore, will all the more have to join forces and bethink ourselves of the synergies inherent in the different specialties, medical licenses, and professions in the health care system, so that we can continue promoting these invaluable resources and to always act to the benefit of our service members but also of the society as a whole. On that note, I wish you all an insightful conference with many interesting talks and constructive discussions. Dr. Tempel Lieutenant General (MC) Surgeon General of the Bundeswehr 7 Program at a Glance Tuesday, April 26 Time 16:00 | 18:00 Audimax A 18:00 | 21:30 Garden Hall Foyer 1 Foyer 2 Biological Threats in the 21st Century Welcoming Reception of the German Society für Military Medicine and Pharmacy at the Reception Hall Wednesday, April 27 Time 08:30 | 10:45 11:15 | 12:30 13:30 | 15:30 16:00 | 18:00 19:00 | 22:30 8 Audimax B C E G Garden Hall Foyer 1 Foyer 2 What should we learn from the Ebola crisis? Coffee Break Ebola Outbreak Response D F H Biological Protection and Environmental Hazards Lunch Break Emerging Zoonotic Infections Industrial Exhibition Next Generation Sequencing Approaches Poster Exhibition Coffee Break Strategies for Preparedness and Management Interactive Voting Session Case Reports Conference Dinner of the German Society für Military Medicine and Pharmacy at Eventstadel, Moosach (Wasserburg) Medical Biodefense Conference 2016 Thursday, April 28 Time 08:30 | 10:30 11:00 | 12:30 Audimax I K Garden Hall J L Outbreak Management: “Ready or Not Here I Come“ Foyer 2 Diagnostics “Sherlock“ at his best Coffee Break Microbial Population Genomics Foyer 1 Virulence Factors and Pathogenic Mechanisms Poster Exhibition Lunch Break Poster Session 13:30 | 15:30 Poster Session Industrial Exhibition Coffee Break 16:00 | 16:15 16:15 | 18:15 Poster Award Ceremony M Anti-Infective Strategies Vaccines and Antibiotics Poster Exhibition N Fostering Biosafety for a Safer World Friday, April 29 Time 08:30 | 10:30 Audimax O P Garden Hall Foyer 1 Foyer 2 Emerging Diversity of Intracellular Agents Coffee Break 11:00 | 13:00 Tick-Borne Pathogens in Nature 9 Tuesday Audimax, 16:00 — 18:00 A 16:00 AO 01 10 Biological Threats in the 21st Century Chairs: D. Frangoulidis (DEU) and S. Bankoul (CHE) Biological Threats in the 21st Century: The Politics, People, Science & Historical Roots F Lentzos King’s College, London, GBR Medical Biodefense Conference 2016 Wednesday Audimax, 08:30 — 10:45 B What should we learn from the Ebola crisis? Opening Session Chairs: L. Zöller (DEU) and G. Peters (DEU) 08:30 Opening and Welcome Notes Conference Chair Director Military Medical Science and Development and Deputy Commandant, Bundeswehr Medical Service Academy President of the German Society for Military Medicine and Pharmacy 09:00 BO 01 The Ebola outbreak in West Africa 2014-2016: operational challenges and lessons learned. P Formenty World Health Organization, Geneve, CHE 09:35 BO 02 The UK Response to Ebola in Sierra Leone AD Green Royal Centre for Defence Medicine ,Birmingham ,GBR 10:10 BO 03 The Ebola Mission –View of the CDC I Damon Centers for Disease Control, Division of High-Consequence Pathogens and Pathology, Atlanta, USA 10:45 Coffee Break Audimax, 11:15 — 12:30 C Ebola Outbreak Response Chairs: R. Wölfel (DEU) and M. Carroll (GBR) 11:15 CO 01 Mobile Laboratories - Lessons-learned during the Ebola Outbreak K Stoecker1, M Gabriel2, E Fleischmann1, A DiCaro3, G Ippolito3, S Günther2, and R Wölfel4 1- Bundeswehr Institute of Microbiology, Med. Bio Reconnaissance& Verification, Munich, DEU; 2- Bernhard-Nocht-Institute, Hamburg, DEU; 3- Instituto Nazionale per le Malattie Infettive, Rome, ITA; 4- Bundeswehr Institute of Microbiology, Bacteriology &Toxicology, Munich, DEU 11:35 CO 02 Biosafety: The Cornerstone of the French Ebola Crisis Response L Koch1, F Janvier2, H Dampierre3, S Madec4, C Bay5, S Larreche6, F Thibault3, E Valade1, and A Merens6 1- IRBA, Bretigny sur Orge, FRA; 2- HIA Saint Anne, Toulon, FRA; 3- DCSSA, Paris, FRA; 4- Centre Medical des Armees, Villacoublay, FRA; 5- École du Val de Grace, Paris, FRA; 6- HIA BEGIN, Saint Mande, FRA 11 Wednesday 11:50 BioMEDEVAC Experience of EVD-Patients in Italy: Lessons Learned CO 03 R Biselli, A Autore, MM Lastilla, P Manfroni Italian Air Force, Logistic Command, Medical Service, Rome, ITA 12:05 Impact of retrospective and real time sequencing on the West African Ebola CO 04 virus outbreak MW Carroll Public Health England, Porton Down, Wiltshire, GBR 12:30 Lunch Break Garden Hall, 11:15 — 12:30 D Biological Protection and Environmental Hazards Chairs: K. Aistleitner (DEU) and B. Niederwöhrmeier (DEU) 11:15 Vecoys and becoys, newly developed nanoparticles for targeted destruction of DO 01 viral and bacterial agents ME El Zowalaty, and TJ Webster Northeastern University, Department of Chemical Engineering, Boston, USA 11:30 Nanosilver System Technology - Countermeasure Against Bioterrorism DO 02 H Schmid Fraunhofer-Institute for Chemical Technology (ICT), Nanotechnology (ES), Pfinztal, DEU 11:45 Assessing the Economic Feasibility of Developing Medical Countermeasures DO 03 against Rare, but Highly Dangerous Agents ML Johnson1, F Dorandeu2, J Belin3, and M Guille4 1- MJ Lawrence Consulting, Munich, DEU; 2- Armed Forces Biomedical Research Institute (IRBA), Brétigny-sur-Orge, FRA; 3- University Bordeaux 4, Gretha -UMR CNRS 5113, Bordeaux, FRA; 4- Université Panthéon-Assas, LEMMA & Labex MMEDII, Paris, FRA 12:00 The wide spread distribution of Bacillus cereus biovar anthracis requires DO 04 practical and cost-effective tool monitoring tools C Hoffmann1, F Zimmermann2, K Nowak1, K Grützmacher1, S Dupke2, K Merkel1, H Kühl3, R Grunow2, S Klee2, S Calvignac-Spencer1, and F Leendertz1 1- Robert Koch-Institute, Epidemiology of Highly Pathogenic Microorganisms, Berlin, DEU; 2- Robert Koch-Institute, Centre for Biological Threats and Special Pathogens, Berlin, DEU; 3- Max Planck Institute for Evolutionary Anthropology, Primatology, Leipzig, DEU 12:15 Safety Cabinets - A fundamental protective device DO 05 T Hinrichs Berner International GmbH, Elmshorn, DEU 12:30 12 Lunch Break Medical Biodefense Conference 2016 Wednesday Audimax, 13:30 — 15:30 E Emerging Zoonotic Infections Advanced training session by the Center for Infection Medicine Munich (CIMM) Chairs: A. Fasanella (ITA) and J. Schmidt-Chanasit (DEU) 13:30 EO 01 Emerging viral zoonotic infections of the central nervous system D Tappe Bernhard Nocht Institute, Hamburg, DEU 13:50 EO 02 Zika virus emergence in the Americas – A potential threat to Europe? J Schmidt-Chanasit WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Department of Arbovirology, Hamburg, DEU 14:10 EO 03 SARS vs MERS: a comparison based on clinical and epidemiological data G Jahn Institute of Medical Virology and Epidemiology of Viral Disease, University Hospital of Tübingen, Tübingen, DEU 14:30 EO 04 Prevalence rates of Rift Valley Fever infections in Mauritania, Sierra Leone, Cameroon and the Democratic Republic of Congo M Eiden, M Rissmann, and MH Groschup Institut für Neue und Neuartige Tierseuchenerreger, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, DEU 14:45 EO 05 Detection of human infections by non-rodent associated hantaviruses in Africa P Heinemann1, PT Witkowski1, SS Essbauer2, N Kruger1, CG Akoua-Koffi3, F Schaumburg4, FH Leendertz5, and DH Kruger1 1- Charité School of Medicine, Institute of Virology, Berlin, DEU; 2- Bundeswehr, Institute of Microbiology, Munich, DEU; 3- University of Bouake, Centre de Recherche pour le Developpement, Bouake, CIV; 4- University Hospital Munster, Medical Microbiology, Munster, DEU; 5- Robert Koch-Institute, Berlin, DEU 15:00 EO 06 Analysis of bat-borne Makokou virus underlines the risk of emergence of nonconventional hantaviruses PT Witkowski1, JF Drexler2, R Kallies2, M Lickova3, S Bokorova4, GD Maganga5, T Szemes4, EM Leroy5, DH Kruger1, C Drosten2, and B Klempa1 1- Charité School of Medicine, Institute of Virology, Berlin, DEU; 2- University of Bonn Medical Center, Institute of Virology, Bonn, DEU; 3- Slovak Academy of Sciences, Institute of Virology, Bratislava, SVK; 4- Comenius University, Department of Molecular Biology, Bratislava, SVK; 5- Centre International de Recherches Médicales, Franceville, GAB 15:15 EO 07 Hantavirus in Pet Rats: A Newly Emerging Disease in the UK J Duggan1, R Close2, L McCann3, N McCarthy4, T Mannes5, D Wright6, M Keys1, A Walsh7, A Charlett8, and T Brooks1 1- Public Health England, Rare and Imported Pathogens Laboratory, Salisbury, GBR; 2- Public Health England, CRCE, Oxford, GBR; 3- NHS South Gloucestershire 13 Wednesday Trust, Gloucester, GBR; 4- Warwick University, Warwick Medical School, Warwick, UK; 5- Public Health England, Health Protection Services, Oxford, GBR; 6- Public Health England, Virus and Pathogenesis group, Salisbury, GBR; 7- Public Health England, Gastrointestinal, Emerging and Zoonoses Infections, London, GBR; 8Public Health England, Statistics and Economic Modelling Department, London, GBR 15:30 Coffee Break Garden Hall, 13:30 — 15:30 F 14 Next Generation Sequencing Approaches Chairs: N. Loman (GBR) and L. Baillie (GBR) 13:30 FO 01 Uniting diagnostics and pathogen surveillance with sequencing NJ Loman University of Birmingham, Institute for Microbiology and Infection, Birmingham, GBR 13:55 FO 02 Sequencing’s day out: Take your mini on the field MH Antwerpen, E Georgi1, GH Genzel1, K Stoecker2, and MC Walter1 1- Bundeswehr Institute of Microbiology, Microbial Genomics and Bioforensics, Munich, DEU; 2- Bundeswehr Institute of Microbiology, Reconnaissance and Verification, Munich, DEU 14:15 FO 03 Genome Analysis Reveals Identical Francisella tularensis Strains Across Large Spatial and Temporal Distances DM Wagner1, A Johansson2, C Dwibedi2, D Birdsell1, K Myrtennäs3, J Thelaus3, P Keim1, and M Forsman3 1- Northern Arizona University, Flagstaff, AZ, USA; 2- Umeå University, Umeå, SWE; 3- Swedish Defense Research Agency, Umeå, SWE 14:35 FO 04 Unique genome of a European variola virus identified in a 100 year-old preserved tissue P Pajer1, J Dresler1, D Elleder2, H Kabickova1, L Pisa1, P Aganov1, V Kuzelka3, P Veleminsky3, J Klimentova3, A Fucikova4, J Peichal4, V Benes5, T Raush6, P Dundr6, A Pilin6, A Cabala6, M Hubalek7, J Stribrny8, K Fucik8, M Antwerpen9, and H Meyer9 1- Military Health Institut, Prague, CZE; 2- Institute of Molecular Genetics, Prague, CZE; 3- National Museum, Prague, CZE; 4- Faculty of Military Health Sciences, Hradec Kralove, CZE; 5- Genomics Core Facility, EMBL, Heidelberg, DEU; 6 Faculty of Medicine, Prague, CZE; 7 - State Office for Nuclear Safety, Prague, CZE; 8 - Military Institute of Forensic Medicine, Prague, CZE; 9 - Bundeswehr Institute of Microbiology, Munich, DEU 14:50 FO 05 BSL3-4 agents in the Czech National Museum depository and their value for the study of these organisms J Dresler1, P Pajer1, D Elleder1, T Hron2, H Kabickova1, P Aganov1, L Pisa1, V Kuzelka1, P Veleminsky3, J Klimentova3, A Fucikova4, V Benes4, T Rausch5, P Medical Biodefense Conference 2016 Wednesday Dundr5, A Pilin6, R Cabala6, M Hubalek6, J Stribrny6, K Fucik1, E Liebler-Tenorio1, M Elschner9, M Antwerpen10, and H Meyer10 1- Military Health Institute, Prague, CZE; 2- Institute of Molecular Genetics AS CR, Prague, CZE; 3- National Museum, Prague, CZE; 4- Faculty of Military Health Sciences, Prague, CZE; 5- Genomics Core Facility, EMBL, Heidelberg, DEU; 6- 1st Faculty of Medicine UK, Prague, CZE; 7- Institute of Organic Chemistry and Biochemistry AS, Prague, CZE; 8- Central Military Hospital, Prague, CZE; 9Friedrich Loeffler Institut, Jena, DEU; 10- Bundeswehr Institute of Microbiology, Munich, DEU 15:05 FO 06 Structure of recombination sites in the genome of the european subtype strains of tick borne encephalitis virus, revealed by bioinformatics methods Y Dzhioev1, A Paramonov1, I Kozlova1, S Tkachev2, O Suntsova1, E Doroschenko1, O Lisak1, T Demina3, A Lyapunov2, V Zlobin4, D Kiselev4, D Ruzek5, and D Ruzek5 1- Scientific Centre of Family Health and Human Reproduction Problems, Irkutsk, RUS; 2- Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, RUS; 3- Irkutsk State Academy of Agriculture, Irkutsk, RUS; 4- Irkutsk State Medical University, Irkutsk, RUS; 5- Veterinary Research Institute, Department of Virology, Brno, CZE 15:30 Coffee Break Audimax, 16:00 — 18:00 G Strategies for Preparedness and Management Chairs: H. Meyer (DEU) and L. Schaade (DEU) 16:00 Implications of rare non-predictable unknown infectious disease threats on GO 01 emergency and disaster management planning NG Schwarz Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Global Partnership Initiated Biosecurity Academia for Controlling Health Threats (GIBACHT), Hamburg, DEU 16:15 Assessing Measures to Mitigate the Effects of an Emerging Infectious Disease GO 02 RL Cubeta, and JK Burr Institute for Defense Analyses, Strategy, Forces, and Resources Division, Alexandria, Virginia, USA 16:30 NATO working group HFM RTG 230: “Development of depository of fast and GO 03 reliable detection methods for zoonotic and vector-borne agents” L Wilmaerts1, C Cochez1, V Neubauerova2, J Marié3, A Binder4, U Schotte4, M Faulde5, S Essbauer6, F Lista7, G Faggioni7, D Popescu8, A Zerjav9, P WardDemo10, C Vandenvelde1, and P Heyman1 1- Military Hospital Queen Astrid, Brussels, BEL; 2- Military Health Institute, Prague, CZE; 3- Regional Medical Command, Toulon, FRA; 4- Central Institute of the Bundeswehr Medical Service Kiel, Department of Veterinary Medicine, Kronshagen, DEU; 5- Central Institute of the Bundeswehr Medical Service, Laborgruppe 15 Wednesday Medizinische Zoologie, Koblenz, DEU; 6- Institute for Microbiology of the Bundeswehr, Munich, DEU; 7- Army Medical and Veterinary Research Center, Rome, ITA; 8- Military Medical Research Center, Bucharest, ROU; 9- Military Veterinary Unit, Kocevska Reka, SVN; 10- US Africa Command, Stuttgart, DEU 16:45 The Analytical Task Force Biology GO 04 S Lenerz, N Derakshani, and M Hermann-Pietsch Federal Office of Civil Protection and Disaster Assistance, science and technology, Bonn, DEU 17:00 Building Capacity for Pandemic Influenza and Emerging Infectious Disease GO 05 Preparedness in the US European Command Area of Responsibility KC Allen, and JA Steele U.S. European Command Headquarters, Counter Biothreats Cell, Stuttgart, DEU 17:15 Nordic biopreparedness network initiative GO 06 M Byström1, SL Feruglio2, K Fuursted3, S Helgadóttir4, M Bronislaw Oleksiewicz3, J Strand Olsen5, S Sissonen6, and A Lundin Zumpe7 1- Swedish Defence Research agency, Umeå, SWE; 2- Norwegian Institute of Public Health, Oslo, NOR; 3- Statens Serum Institut, Copenhagen, DNK; 4- LandspitaliUniversity Hospital, Reykjavík, ISL; 5- Norwegian Defence Research Establishment, Kjellner, NOR; 6- National Institute for Health and Welfare, Helsinki, FIN; 7- National Food Agency, Uppsala, SWE 17:30 The Role of Biosafety Associations in Global Biosecurity and Rising GO 07 Awareness on Dual-Use Issues in Biomedical Research LG Bakanidze1, MD Natsvlishvili1, and NV Chakvetadze2 1- Georgian Biosafety Association, Tbilisi, GEO; 2- National Center for Disease Control and Public Health, Tbilisi, GEO 17:45 GO 08 ι 18:00 16 Ten Years of Finnish Interagency Collaboration on Biothreat Preparedness – BUOS and GHSA S Nikkari Centre for Military Medicine, Research and Development Department, Helsinki, FIN Medical Biodefense Conference 2016 Wednesday Garden Hall, 16:00 — 17:40 H Interactive Voting Session - Case Reports Advanced training session by the Center for Infection Medicine Munich (CIMM) and the German Society for Military Medicine and Pharmacy Chairs: S. Zange (DEU) and D. Tappe (DEU) 16:00 HO 01 Emerging infectious diseases linked to the refugee crisis LA Balzer Munich Municipal Hospital Schwabing, Department of infectious diseases and tropical medicine, Munich, DEU 16:20 HO 02 Acute cardiopulmonary syndrome in a 58-yr-old female patient M Simon University Hospital Regensburg, Institute for Medical Microbiology and Hygiene, Regensburg, DEU 16:40 HO 03 Fever, rash, myalgia and conjunctivitis after travel to South America D Tappe Bernhard Nocht Institute, Hamburg, DEU 17:00 HO 04 Skin lesion of unknown origin IB Eder University Hospital,Leipzig , Institute of Medical Microbiology and Epidemiology of Infectious Diseases, Leipzig, DEU 17:20 HO 05 Ι 17:40 Just a little skin blister... T Holzmann, and U Reischl Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, DEU 17 Thursday Audimax, 08:30 — 10:30 I 18 Outbreak Management: “Ready or Not - Here I Come“ Chairs: T. Ingles (AUS) and G. Genzel (DEU) 08:30 IO 01 Melioidosis: a decade of international bioreconnaissance. TJ Inglis1 and AJ Merritt2 1- University of Western Australia, School of Pathology & Laboratory Medicine, Crawley, AUS; 2- PathWest Laboratory Medicine, Department of Microbiology, Nedlands, AUS 09:00 IO 02 Outbreak response in the aftermath of West Africa´s Ebola Crisis – VISIT: a civilmilitary interface pilot. K Rossmann Bundeswehr Medical Headquarters, Munich, DEU 09:15 IO 03 Pneumonic plague outbreak of Mandritsara: the involvement of traditional healers V Andrianaivoarimanana1, R Rabeviloma2, N Randriananja3, MO Raveloson2, and M Rajerison1 1- Institut Pasteur de Madagascar, Plague Unit, Antananarivo, MDG; 2- Ministry of Health, District Service of Public Health, Mandritsara, MDG; 3- Ministry of Health, Central laboratory for Plague, Antananarivo, MDG 09:30 IO 04 Generic action plan for biological danger situations D Oberndörfer1, V Wilken1, R Gottschalk2, H Jung2, and E Finke3 1- Frankfurter Institut für Rettungsmedizin & Notfallversorgung, Branddirektion Frankfurt, Frankfurt/Main, DEU; 2- Gesundheitsamt Frankfurt, Frankfurt/Main, DEU; 3- AKNZ, München, DEU 09:45 IO 05 After Ebola: Moving forward on preparedness for unusual disease outbreaks I Hunger Robert Koch Institute, ZBS, Berlin, DEU 10:00 IO 06 Causative Food Unknown? Investigational Tracing of Foods as a Tool for Outbreak Management P Luber, N Becker, K Heckenbach, D Raschke, and T Schewe Federal Office of Consumer Protection and Food Safety (BVL), Food Safety, Berlin, DEU 10:15 IO 07 An Anthrax Outbreak in a Village in Central Anantolia and Infection Control Studies M Doganay1, H Demiraslan1, A Borlu2, S Sahin3, F Büyük4, Y Karadag3, and M Sahin4 1- Erciyes University, Department of Infectious Diseases, Kayseri, TUR; 2- Erciyes University, Department of Public Health, Kayseri, TUR; 3- Ministry of Health, Public Health Service, Kayseri, TUR; 4- Kafkas University, Department of Microbiology, Veterinary Faculty, Kars, TUR 10:30 Coffee Break Medical Biodefense Conference 2016 Thursday Garden Hall, 08:30 — 10:30 J Diagnostics - “Sherlock“ at his best Chairs: M. Beer (DEU) and D. Frangoulidis (DEU) 08:30 JO 01 Rapid Diagnostics and Pen-Side Testing – State-of-the-Art S Blome, K Goller, K Wernike, B Hoffmann, and M Beer Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Greifswald-Insel Riems, DEU 08:55 JO 02 Benefits and Limitations of Cartridge-based Tests in Molecular Diagnostics of Infectious Diseases U Reischl University Hospital Regensburg, Institute of Medical Microbiology and Hygiene, Regensburg, DEU 09:20 JO 03 FISH for diagnosis of infections: Closing the gap between bench and bedside A Moter Biofilmcenter, German Heart Institute Berlin, Berlin, DEU 09:45 JO 04 Development of a sensitive and specific real-time RT-PCR for simultaneous detection of Dengue and Zika virus infections S Wölfel1, T Löscher2, G Dobler1, and R Wölfel3 1- Bundeswehr Institute of Microbiology, Virology & Rickettsiology, Munich , DEU; 2Ludwig Maximilians University of Munich, Department of Infectious Diseases and Tropical Medicine, Munich, DEU; 3- Bundeswehr Institute of Microbiology, Bacteriology, Munich, DEU 10:00 JO 05 Culture-independent serotyping of Legionella pneumophila in water, aerosol and urine samples C Kober1, A Wunderlich1, C Herr2, C Lück3, R Niessner1, and M Seidel1 1- Technical University of Munich, Institute of Hydrochemistry, Chair of Analytical Chemistry, Munich, DEU; 2- Occupational and Environmental Health, Epidemiology, Bavarian Health and Food Safety Authority, Munich, DEU; 3- Technical University of Dresden, Institute of Medical Microbiology and Hygiene, Institute of Virology, Medical Faculty "C.G. Carus", Dresden, DEU 10:15 JO 06 Interlaboratory validation for antimicrobial susceptibility testing of highly pathogenic bacteria – results of the QUANDHIP AST working group S Zange, P Bolton2, T Boskani3, G Ezpeleta4, E Georgi1, R Grunow5, P Jureen3, J Papaparaskevas6, O Telleria4, BR Thoma1, A Tsakris6, T Wahab3, and D Jacob5 1- Bundeswehr Institute of Microbiology, Central Diagnostic Unit, Munich, DEU; 2- Public Health England, Rare and Imported Pathogens Laboratory, Porton Down, GBR; 3- Public Health Agency of Sweden, Department of Microbiology, Stockholm, SWE; 4- Basurto University Hospital, Clinical Microbiology and Infection Control Department, Bilbao, ESP; 5- Robert Koch-Institut, Centre for Biological Threats and Special Pathogens (ZBS 2), Berlin, DEU; 6- National and Kapodistrian University of Athens, Medical School, Microbiology Department, Athens, GRC Coffee Break 10:30 19 Thursday Audimax, 11:00 — 12:30 K 20 Microbial Population Genomics Chairs: P. Keim (USA) and G. Vergnaud (FRA) 11:00 KO 01 Anthrax Genomics for Investigating Disease Outbreaks P Keim Northern Arizona University, Flagstaff, AZ, USA 11:25 KO 02 The scientific names of bacterial pathogens: the importance of trivia. BJ Tindall Leibniz-Institut DSMZ, Braunschweig, DEU 11:40 KO 03 Phylogenomics and geographic distribution of Bacillus cereus biovar anthracis in sub-Saharan Africa SR Klee1, KS Antonation2, K Grützmacher3, S Dupke1, P Mabon2, F Zimmermann1, R Grunow1, S Calvignac-Spencer3, CR Corbett2, and FH Leendertz3 1- Robert Koch-Institut, ZBS2 (Highly Pathogenic Microorganisms), Berlin, DEU; 2Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, CAN; 3- Robert Koch-Institut, P3 (Epidemiology of Highly Pathogenic Microorganisms), Berlin, DEU 11:55 KO 04 Updating the Brucella MLVA database G Vergnaud1, Y Hauck1, C Pourcel1, I Jacques2, A Cloeckaert2, and M Zygmunt2 1- University Paris-Saclay, I2BC, ORSAY, FRA; 2- INRA, Infectiologie et Santé Publique, Nouzilly, FRA 12:10 KO 06 Characterization of Clostridum botulinum group I through a 134 SNPs Panel S Fillo1, F Giordani1, A Anselmo1, F Anniballi2, A Fortunato1, A Palozzi1, B Gentile1, D Azarnia Tehran1, A Ciammaruconi1, F Spagnolo1, V Pittiglio1, B Auricchio2, J Dresler3, L Píša4, J Klimentová4, D De Medici2, and F Lista1 1- Army Medical and Veterinary Research Center, Molecular Biology Section, Rome, ITA; 2- Istituto Superiore di Sanità, Department of Veterinary Public Health and Food Safety, National Reference Center for Botulism, Rome, ITA; 3- Military Health Institute, Prague, CZE; 4- Faculty of Military Health Sciences, Hradec Králové, CZE 12:20 KO 07 Insights into microevolution of Burkholderia mallei gained during an experimental infection within its natural host E Georgi1, U Wernery2, MH Antwerpen1, R Wernery2, and HC Scholz1 1- Bundeswehr Institute of Microbiology, Munich, DEU, 2- Central Veterinary Research Laboratory, Dubai, ARE 12:30 Lunch Break Medical Biodefense Conference 2016 Thursday Garden Hall, 11:00 — 12:30 L Virulence Factors and Pathogenic Mechanisms Chairs: A. Charbit (FRA) and H. von Buttlar (DEU) 11:00 LO 01 Metabolism and Francisella tularensis intracellular adaptation A Charbit Université Paris, Institut Necker-Enfants Malades, Paris, FRA 11:20 LO 02 Q-detect: using cell mediated immunity to monitor C. burnetii infections A Garritsen1, HI Roest2, MJ de Vries-van der Horst1, PM Schneeberger3, and ML Kouwijzer1 1- Innatoss Laboratories, Oss, NLD; 2- Central Veterinary Institute, Lelystad, Netherlands; 3- Jeroen Bosch Hospital, LMM, Den Bosch, NLD 11:35 LO 03 Identification of Novel Bacillus anthracis Virulence Factors by a Proteomic/ Serological Approach and their Application in Vaccine Development T Chitlaru, M Israeli, E Barhaim, U Elia, S Rotem, S Ehrlich, O Cohen, and A Shafferman Israel Institute for Biological Research, Biochemistry and Molecular Genetics, Ness Ziona, ISR 11:50 LO 04 The Impact of Environmental Contamination with Bacillus anthracis Spores on Human Health F Buyuk1, O Celebi1, E Linley2, C Cooper3, M Doganay4, M Sahin1, and L Baillie2 1- Kafkas University, Department of Microbiology, Kars, TUR; 2- Cardiff University, School of Pharmacy and Pharmaceutical Science, Cardiff, GBR; 3- Stockholm University, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm, SWE; 4- Erciyes University, Department of Infectious Diseases, Kayseri, TUR 12:05 LO 05 An in vitro evaluation of epigallocatechin gallate (eGCG) as a biocompatible inhibitor of ricin and Clostridium difficile toxins. P Dyer1, S Shorter1, S Richardson1, and L Baillie2 1- University of Greenwich, Life and Sport Science, Chatham Maritime, GBR; 2University of Cardiff, School of Pharmacy & Pharmaceutical Science, Cardiff, GBR 12:20 LO 06 Qualitative and quantitative detection of botulinum neurotoxins from complex matrices: results of the first international proficiency test S Worbs1, U Fiebig1, R Zeleny2, H Schimmel2, A Rummel3, W Luginbühl4, and BG Dorner1 1- Robert Koch Institut, ZBS3, Berlin, DEU; 2- European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel, BEL; 3- toxogen GmbH, Hannover, DEU; 4- ChemStat, Bern, CHE 12:30 Lunch Break 21 Thursday Audimax, 16:15 — 18:10 M Anti-Infective Strategies - Vaccines and Antibiotics Chairs: G. Sutter (DEU) and L. Zöller (DEU) 16:15 Who needs anthrax vaccine? MO 01 H Dyson Dstl Porton Down, Salisbury, GBR 16:40 Ebola vaccine development – Which lessons did we learn? MO 02 A von Krempelhuber, M Saeftel, and J Vollmar GlaxoSmithKline GmbH & Co. KG, Medical Therapeutic Area Vaccines, Travel- and Tropical Medicine, Munich, DEU 16:55 Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering MO 03 Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein A Volz1, A Kupke2, F Song1, S Jany1, R Fux1, H Shams-Eldin2, J Schmidt2, C Becker3, M Eickmann2, S Becker2, and G Sutter1 1- LMU Munich, Institute for Infectious Diseases and Zoonoses, Chair for Virology, Munich, DEU; 2- Philipps University Marburg, Institute of Virology, Marburg, DEU; 3- University of Giessen Lung Center, Department of Internal Medicine II, Section of Infectious Diseases, Giessen, DEU 17:10 Update on MVA-BN® Smallpox Vaccine (IMVANEX®/IMVAMUNE®) and Use of the MO 04 MVA-BN® Platform to address the Need for an Ebola Vaccine N Samy1, A Volkmann2, B Petzold3, and P Chaplin4 1- Bavarian Nordic, Clinical Development, Martinsried, DEU; 2- Bavarian Nordic, Early Development, Martinsried, DEU; 3- Bavarian Nordic, Regulatory, Martinsried, DEU; 4Bavarian Nordic, Executive Management, Kvistgard, DNK 17:25 Finafloxacin Evades Burkholderia pseudomallei Efflux-mediated Fluoroquinolone MO 05 Resistance LB Randall, E Georgi, GH Genzel2, and HP Schweizer1 1- University of Florida, Molecular Genetics and Microbiology, Gainesville, USA; 2Bundeswehr Institute of Microbiology, Munich, DEU 17:40 Therapeutic efficacy of single and combined antibiotic treatments against Anthrax MO 06 S Weiss, Z Altboum, I Glinert, A Sittner, E Bar David, D Kobiler, and H Levy IIBR, Infectious Diseases, Ness-Ziona, ISR 17:55 Q-VaxCelerate: Development of a T Cell-Based Vaccine for Q Fever MO 07 A Garritsen1, L Moise2, PB Reeves3, G Richard2, S Raju Paul3, TA Luijjkx1, L Baeten4, RA Bowen4, R Bucala5, A Sluder3, and MB Poznansly3 1- Innatoss Laboratories BV, Oss, NLD; 2- Epivax, Providence RI, USA; 3- Massachusetts General Hospital, Vaccine and Immunotherapy Center, Charlestown MA, USA; 4Colorado State University, Animal Reproduction and Biotechnology Laboratory, Fort ι Collins CO, USA; 5- Yale School of Medicine, Department of Internal Medicine, New 18:10 Haven CT, USA 22 Medical Biodefense Conference 2016 Thursday Garden Hall, 16:15 — 18:40 N Fostering Biosafety for a Safer World Advanced training session by the German Partnership Program for Excellence in Biological and Health Security Chairs: R. Surkau (DEU) and S. Essbauer (DEU) 16:15 Fostering Biosafety and Biosecurity for a Safer World: The Example of the NO 01 German Partnership Program for Excellence in Biological and Health Security R Surkau1, W Biederbick2, and J Von Bonin3 1- German Federal Foreign Office, Program Director of the German Partnership Program for Excellence in Biological and Health Security and Deputy Head of the German Federal Foreign Office’s Division for Biological and Chemical Arms Control, Disarmament and Non-Proliferation, Berlin, DEU; 2- Robert Koch Institute, Head of the Program Office and Program Coordinator of the German Partnership Program for Excellence in Biological and Health Security at the Robert Koch Institute and Head of the Department ‘Strengthening Global Biosecurity’ at the Robert Koch Institute, Berlin, DEU; 3- Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH, Program Manager of the German Partnership Program for Excellence in Biological and Health Security at GIZ, Berlin, DEU 16:45 The Role of German-Sudanese Partnership in Strengthening Biorisk NO 02 Management in the Republic of the Sudan BI Fadul1, IE Andernach2, R Stelter3, J Wolf4, A Abdulkarim1 1- National Public Health Laboratory, Khartoum, SDN; 2- Robert Koch Institute, Centre for Biological Threats and Special Pathogens - Highly Pathogenic Microorganisms, Berlin, DEU; 3- Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH, Section Security, Crisis Management, Refugee Programmes, Berlin, DEU; 4- Robert Koch Institute, Strengthening Global Biosecurity, Berlin, DEU 17:00 Early Warning System in Tunisia: Evolution, Challenges and Role of NO 03 Laboratory, Biosecurity, Environment and Modeling of Infectious Diseases NB Ben Alaya1, S El Bekri2, M Nachtnebel3, L Hollenweger4, and D Kücükali4 1- National Observatory for New and Emerging Diseases of the Ministry of Health, Tunis, TUN; 2- Directorate for Primary Health Care of the Ministry of Health, Tunis, TUN; 3- Expert Surveillance Unit of the German Partnership Program for Excellence in Biological and Health Security at Robert Koch Institute (RKI), Berlin, DEU; 4German Partnership Program for Excellence in Biological and Health Security at Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ), Berlin, DEU 17:15 Thematic and operational approaches for biosafety and biosecurity in NO 04 Morocco after the Ebola crisis A Maaroufi1, D Röntgen2, and Lilian Hollenweger2 1- Moroccan Ministry of Health, Department of Epidemiology and Disease Control, Rabat, MAR; 2- Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH, German Partnership Program for Excellence in Biological and Health Security, Berlin, DEU 23 Thursday 17:30 Mobile laboratory unit for the fight against Ebola in Mali NO 05 B Kouriba1, B Traoré1, L Timbiné1, A Maiga1, Y Timbiné1, A Touré1, M Knuepfer2, E Fleischmann2, S Thumann2, L Fofona3, F Xavier3, M Summerer4, J Von Bonin4, S Diallo1, and R Woelfel2 1- Centre d’Infectiologie Charles Mérieux du Mali, Bamako, MLI; 2- Bundeswehr Institute of Microbiology, Department of Bacteriology and Toxinology, Munich, DEU; 3- Foundation Mérieux, Bamako, MLI; 4- Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH, Berlin, DEU 17:45 The Global Partnership Initiated Biosecurity Academia for Controlling Health NO 06 Threats (GIBACHT) NG Schwarz1, M Lee2, N Gilberger1, J Pelikan3, E Rutebemberwa4, and A Hoffmann3 1- Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Global Partnership Initiated Biosecurity Academia for Controlling Health Threats (GIBACHT), Hamburg, DEU; 2Robert Koch Institute, Global Partnership Initiated Biosecurity Academia for Controlling Health Threats (GIBACHT), Berlin, DEU; 3- Swiss Tropical and Public Health Institute, Global Partnership Initiated Biosecurity Academia for Controlling Health Threats (GIBACHT), Basel, CHE; 4- African Field Epidemiology Training Network (AFENET), Global Partnership Initiated Biosecurity Academia for Controlling Health Threats (GIBACHT), Kampala, UGA 18:00 Livestock Brucellosis in Pakistan NO 07 H El-Adawy1, I Khan2, F Melzer1, and H Neubauer1 1- Friedrich Loeffler Institut, Institute for Bacterial Infections and Zoonoses, Jena, DEU; 2- College of Veterinary and Animal Sciences, Section of Epidemiology and Public Health, Jhang, PAK 18:15 The biological safety system in Kazakhstan NO 08 A Aikimbayev Sci Pract. Center San. Epid. Expertise and Monitoring, Almaty, KAZ ι 18:40 24 Medical Biodefense Conference 2016 Friday Audimax, 08:30 — 10:30 O Emerging Diversity of Intracellular Agents Chairs: R. Massung (USA) and S. Wölfel (DEU) 08:30 Diagnosis and Treatment of Rickettsial Diseases: Pitfalls and Recent OO 01 Advances RF Massung Centers for Disease Control and Prevention, Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, Atlanta, GA, USA 09:00 Assessment of Coxiella burnetii strain differences in virulence and the innate OO 02 immune response of humans H Roest1, R Kuley2, A Ammerdorffer3, and A Bossers2 1- Central Veterinary Institute, part of Wageningen UR, Bacteriology and Epidemiology, Lelystad, NLD; 2- Central Veterinary Institute, part of Wageningen UR, Infection Biology, Lelystad, NLD; 3- Radboud University Medical Center, Internal Medicine, Nijmegen, NLD 09:30 First Molecular Detection of Rickettsia massiliae in Ticks from Tanzania OO 03 B Flach1, M Knüpfer2, K Baumann1, L Chitimia-Dobler1, NE Ntinginya3, L Maboko3, N Heinrich4, M Hölscher4, and G Dobler1 1- Bundeswehr Institute of Microbiology, Virology and Rickettsiology, Munich, DEU; 2- Bundeswehr Institute of Microbiology, Bacteriology and Toxinology, Munich, DEU; 3- NIMR-Mbeya Medical Research Centre, Mbeya, TZA; 4- Division for Infectious Diseases and Tropical Medicine, University of Munich, Munich, DEU 09:45 Survey for the zoonotic bacteria Leptospira and Rickettsia in wild small OO 04 mammal populations in Germany S Fischer1, A Mayer-Scholl2, S Essbauer3, N Kratzmann1, C Imholt4, D Reil4, S Schmidt1, UM Rosenfeld1, J Jacob4, K Nöckler2, and RG Ulrich1 1- Friedrich-Loeffler-Institut, Institute for Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, DEU; 2- Federal Institute for Risk Assessment, Department for Biological Safety, Berlin, DEU; 3- Bundeswehr, Institute of Microbiology, Munich, DEU; 4- Julius Kühn-Institute, Institute for Plant Protection in Horticulture and Forests, Münster, DEU 10:00 Detection and identification of Rickettsia based on fluorescence in situ OO 05 hybridization K Aistleitner1,K Stoecker2,H Ge3, AL Richards3, and R Woelfel1 1- Bundeswehr Institute of Microbiology, Bacteriology and Toxinology, Munich, DEU; 2- Bundeswehr Institute of Microbiology, Munich, DEU; 3- Naval Medical Research Center, Silver Spring, USA 10:15 Southern Kazakhstan as a melting pot for human pathogenic Rickettsiae OO 06 N Turebekov1, Z Shapiyeva2, L Yeraliyeva3, A Dmitrovskiy4, R Yegemberdiyeva4, K Abdiyeva1, A Oradova3, A Amirbekov3, Z Kachiyeva3, L Ziyadina2, D Höper5, A Zhalmagambetova6, S Frey7, J Zinner7, and S Essbauer7 25 Friday 1- Center for International Health, Ludwig-Maximillians-Universität, München, DEU; 2Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring, Department of Parasitology, Almaty, KAZ; 3- Research Institute of Applied and Fundamental Medicine, Kazakh National Medical University, Almaty, KAZ; 4- Kazakh National Medical University, Department of Infectious Diseases, Almaty, KAZ; 5Friedrich-Loeffler-Institut, Greifswald, Isle of Riems, DEU; 6- Deutsche Gesellschaft für Internationale Zusammenarbeit, Almaty, KAZ; 7- Bundeswehr Institute of Microbiology, Munich, DEU 10:30 Coffee Break Audimax, 11:00 — 13:00 P 26 Tick-Borne Pathogens in Nature Chairs: G. Dobler (DEU) and D. Krüger (DEU) 11:00 PO 01 Tick determinants of Powassan virus transmission ME Hermance1, R Santos1, and S Thangamani1,2 1- University of Texas Medical Branch, Department of Pathology, Galveston, TX, USA; 2- University of Texas Medical Branch, Galveston National Laboratory, Galveston, TX, USA 11:30 PO 02 Crimean-Congo Hemorrhagic Fever Virus in Ticks, Kosovo K Sherifi1, D Cadar2, S Muji3, A Robaj4, S Ahmeti5, X Jakupi6, A Krueger7, and P Emmerich2 1- Faculty of Agriculture and Veterinary Medicine, University of Prishtina "Hasan Prishtina", Veterinary Medicine, Prishtina, XXK; 2- Bernhard Nocht Institute for Tropical Medicine, Hamburg, Department of Virology, Hamburg, DEU; 3- Faculty of Agriculture and Veterinary Medicine, University of Prishtina "Hasan Prishtina", University of Prishtina "Hasan Prishtina", Prishtina, XXK; 4- Faculty of Agriculture and Veterinary Medicine, University of Prishtina "Hasan Prishtina", XXK; 5- Clinic of Infectious Diseases, University Clinical Centre, Prishtina, XXK; 6- National Institute of Public Health, Department of Microbiology, Prishtina, XXK; 7- Bundeswehr Hospital Hamburg,Department of Tropical Medicine, Hamburg, DEU 11:45 PO 03 Epidemiology and surveillance of arthropod borne diseases in febrile patients in Southwestern Tanzania CD Mangu1, HB Msila1, B Flach2, K Baumann2, L Maboko3, G Dobler2, and N Heinrich4 1- NIMR-Mbeya Medical Research Center, TB and Emerging Diseases, Mbeya, TZA; 2- Bundeswehr Institute for Microbiology, Virology and Rickettsiology, Munich, DEU; 3 - NIMR-Mbeya Medical Research Center, Center Director, Mbeya, TZA; 4- University of Munich (LMU), Division for Infectious Diseases and Tropical Medicine, Munich, DEU 12:00 PO 04 Epidemiological and Molecular Biological Characterization of TBEV in Mongolia D Tserennorov1, D Höper2, K Binder3, J Zinner4, G Dobler4, B Baigalmaa1, B Uyanga1, H Scholz5, J Riehm6, D Kiefer7, S Essbauer4, and S Frey4 Medical Biodefense Conference 2016 Friday 1- National Center for Zoonotic Diseases, Ulaanbaatar, MNG; 2- Friedrich-LoefflerInstitute, Institute of Diagnostic Virology, Greifswald, Isle of Riems, Germany; 3Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Oberschleißheim, DEU; 4- Bundeswehr Institute of Microbiology, Virology & Rickettsiology, Munich, DEU; 5- Bundeswehr Institute of Microbiology, Bacteriology & Toxinology, Munich, DEU; 6- Zentrales Institut des Sanitätsdienstes der Bundeswehr, Abteilung II Veterinärmedizin, Garching, DEU; 7- Ben-Gurion University of the Negev, The Jacob Blaustein Institutes for Desert Research, Midreshet Ben-Gurion, ISR 12:15 PO 05 The South of Kazakhstan is a hotspot for the Siberian Subtype of Tick-borne encephalitis virus K Abdiyeva1, N Turebekov1, Z Shapiyeva2, L Ziyadina2, A Dmitrovskiy3, R Yegemberdiyeva3, L Yeraliyeva3, A Oradova3, Z Kachiyeva3, A Amirbekov3, D Höper4, A Zhalmagambetova5, J Zinner6, S Essbauer6, and S Frey6 1- Center for International Health, Ludwig-Maximillians-Universität, Munich, DEU; 2Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring, Almaty, KAZ; 3- Kazakh National Medical University, Almaty, KAZ; 4- FriedrichLoeffler-Institute, Greifswald, Isle of Riems, DEU; 5- Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ), Almaty, KAZ; 6- Bundeswehr Institute of Microbiology, Munich, DEU 12:30 PO 06 Phylogenetics of Austrian TBE viruses M Bestehorn1, L Chitimia-Dobler1, FX Heinz2, and G Dobler1 1- Bundeswehr Institute of Microbiology, Dept of Virology and Rickettsiology, Munich, DEU; 2- Institute of Virology, Medical University of Vienna, Vienna, AUT 12:45 PO 07 The study of genetic diversity and biological properties of tick-borne encephalitis virus strains of European subtype isolated in different regions of Russia S Tkachev1, I Kozlova2, Y Dzhioev3, M Verkhozina4, E Doroschenko2, O Lisak2, T Demina5, O Suntsova2, A Paramonov2, A Lyapunov2, A Borisenko2, D Kiselev6, A Tikunov1, N Tikunova1, V Zlobin7, and D Ruzek8 1 - Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of molecular microbiology, Novosibirsk, RUS; 2- FSSFE Scientific Centre of Family Health and Human Reproduction Problems SB RAMS, Laboratory of Molecular Epidemiology and Genetic Diagnostics, Irkutsk, RUS; 3- FSSFE Scientific Centre of Family Health and Human Reproduction Problems SB RAMS; Institute of Biomedical Technology, Irkutsk State Medical University of Russian Ministry of Health, Laboratory of Molecular Epidemiology and Genetic Diagnostics; Laboratory of Molecular Virology and Biotechnology, Irkutsk, RUS, 4- Centre for Epidemiology and Hygiene in Irkutsk region, Department of Virology Research and PCR Laboratory, Irkutsk, RUS; 5Irkutsk State Agricultural University named by A.A. Ezhevsky, Irkutsk, RUS; 6- Irkutsk State Medical University, Department of Microbiology, Virology and Immunology, Irkutsk, RUS; 7- Institute of Biomedical Technology, Irkutsk State Medical University of Russian Ministry of Heath; Irkutsk State Medical University, Laboratory of Molecular Virology and Biotechnology; Department of Microbiology, Virology and Immunology, Irkutsk, RUS; 8-Biology Centre of the Academy of Sciences of the Czech Republic; Veterinary Research Institute, Laboratory of Arbovirology; Department of Virology, Brno, CZE ι 13:00 27 Biosecurity Lounge Visit the Biosecurity Lounge of the German Partnership Program for Excellence in Biological and Health Security at the 15th Medical Biodefence Conference When biosecurity experts meet there’s a lot to talk about. In our Biosecurity Lounge we offer a space for scientific exchange, networking und informal meetings. And since we know that passionate debates need powerful thinkers we help you refill your batteries – with a selection of coffee, tea and refreshments in the lounge. The German Partnership Program for Excellence in Biological and Health Security is all about international biosecurity experts connecting. With the goal to minimise the risks associated with biological substances and pathogens, we offer platforms for exchange, training programs and rooms for debate. We are convinced that scientific friendships around the world and a qualified, engaged scientific community are an important contribution towards global biological and health security. The German Partnership Program for Excellence in Biological and Health Security is engaged globally 28 Medical Biodefense Conference 2016 Let an exhibition about our work with our partners inspire you! A part of our Lounge is an art exhibition that will show you new perspectives on biosafety and biosecurity as well as on the people working with us on improving biosecurity. We welcome you at the Biosecurity Lounge throughout the conference hours at the “Lichthof”-atrium at the 1st floor of the main conference building. 29 Poster Presentations CP 30 Ebola Outbreak Response CP 01 Successful Application and Use of Modified Shipping Containers for Laboratory Diagnostics and Emergency Patient Transport to Support the Ebola Disease Outbreak Response in West Africa K van der Horst1, J Coffin1, D Roberts1, D McCampbell1, GW Carter1, P Haney3, J Bogan1, M Cassler2, D Gray3, J Fair1, and K Yeh1 1- MRIGlobal, Rockville, MD, USA; 2- MRIGlobal, Palm Bay, FL, USA; 3- MRIGlobal, Kansas City, MO, USA CP 02 Characterization of a Ebola lateral flow rapid test detecting VP 40 P Miethe1, MN Faly2, HH Söffing3, and AM Gad3 1- FZMB GmbH, Bad Langensalza, DEU; 2- Hospital National Donka, Laboratoire de Virologie, Conakry, GIN; 3- Senova GmbH, Weimar, DEU CP 03 Ebolavirus: laboratory countermeasures in Western Australia TJ Inglis1, G Chidlow2, and AJ Merritt2 1- University of Western Australia, School of Pathology & Laboratory Medicine, C, AUS; 2PathWest Laboratory Medicine, Department of Microbiology, Nedlands, AUS CP 04 Ebola virus stability in biological specimens during short term storage under different environmental conditions B Pályi1, N Magyar1, B Szalai1, Á Farkas1, T Strecker2, and Z Kis1 1- National Center for Epidemiology, National Biosafety Laboratory, Budapest, HUN; 2Philipps University Marburg, Institute of Virology, Marburg, DEU CP 05 Sorting the wheat from the chaff: cases with and without Ebola in the UK and Sierra Leone TJ Brooks1, A Simpson1, E Aarons1, N Bentley2, I Goodfellow3, and AE Semper1 1- PHE, RIPL, Salisbury, GBR; 2- PHE, SMS, Salisbury, GBR; 3- University of Cambridge, Virology, Cambridge, GBR CP 06 Delivering a clinical laboratory capability to support two Ebola Virus Disease Treatment Centres in Sierra Leone G Fitchett, E Hutley, D McKee, and A Dixon UK MOD, Centre of Defence Pathology, Birmingham, GBR CP 07 Ebolavirus outbreak in West Africa – Portuguese laboratory response overview R Cordeiro, A Pelerito, I Lopes de Carvalho, and S Núncio National Institute of Health Doutor Ricardo Jorge, Infectious Diseases Department, Lisboa, PRT CP 08 High Resolution Molecular Analysis of Patients During the Ebola Outbreak in West Africa WA Valdivia-Granda Orion Integrated Biosciences, New York, USA Medical Biodefense Conference 2016 DP Biological Protection and Environmental Hazards DP 01 Application of carrier assays for screening of effective sporicidal disinfectants for PPE disinfection K Lemmer, S Howaldt, R Heinrich, and R Grunow Robert Koch-Institute, Centre for Biological Threats and Special Pathogens (ZBS 2), Berlin, DEU DP 02 Disinfection of high-containment laboratories by dry fogging with peracetic acid J Schinköthe1, S Reiche1, S Diederich2, and JP Teifke1 1- Friedrich-Loeffler-Institut, Department of Experimental Animal Facilities and Biorisk Management, Greifswald - Insel Riems, DEU; 2- Friedrich-Loeffler-Institut, Institute of Novel and Emerging Infectious Diseases, Greifswald - Insel Riems, DEU DP 03 Biosafety Cabinets: Influence of Personnel Activities T Hinrichs, S Gragert, and M Klein Berner International GmbH, Elmshorn, DEU DP 04 Biosafety Cabinets: Performance Envelope Testing T Hinrichs, S Gragert, and M Klein Berner International GmbH, , Elmshorn, DEU DP 05 A heterogeneous population of motile Brucellae out of the frog pond S Al-Dahouk1, S Köhler2, A Occhialini2, MP Jiménez de Bagüés3, JA Hammerl1, T Eisenberg4, G Vergnaud5, A Cloeckaert6, MS Zygmunt6, AM Whatmore7, F Melzer8, KP Drees9, JT Foster9, AR Wattam10, and HC Scholz11 1- Federal Institute for Risk Assessment (BfR), Department of Biological Safety, Berlin, DEU; 2- Université Montpellier, Centre d’études d’agents Pathogènes et Biotechnologies pour la Santé (CPBS), CNRS, FRE3689, CPBS, Montpellier, FRA; 3- Unidad de Producción y Sanidad Animal, Centro de Investigación y Tecnología Agroalimentaria, Instituto Agroalimentario de Aragón – IA2 (CITA-Universidad de Zaragoza), Zaragoza, ESP; 4Landesbetrieb Hessisches Landeslabor, Gießen, DEU; 5- Université Paris-Saclay, I2BC, CNRS, CEA, Univ. Paris-Sud, Orsay, FRA; 6- Infectiologie et Santé Publique, INRA, UMR1282, Nouzilly, FRA; 7- Animal & Plant Health Agency, Addlestone, GBR; 8- FriedrichLoeffler-Institut, German National Reference Centre for Human and Animal Brucellosis, Jena, DEU; 9- University of New Hampshire, Department of Molecular, Cellular, and Biomedical Sciences, Durham, NH, USA; 10- Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA; 11- Bundeswehr Institute of Microbiology, , Munich, DEU DP 06 Biocidal and sporicidal efficacy of peracetic acid against bacterial agents at potential bioterroristic use. Study on stability of two commercial products: Pathoster® 0,35% and Pathoster® 0,5%. A Fasanella1, A Candeliere2, L Antonino2, M Iatarola1, F Tolve1, L Civita1, and E Campese1 1- Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, Anthrax Reference Centre of ITA, Foggia, ITA; 2- Cerichem Biopharm SRL, Cerignola, ITA 31 Poster Presentations 32 DP Biological Protection and Environmental Hazards DP 07 Generation of Legionella Containing Shower Aerosols for the Investigation of the Possible Infection Process B Kiwull1, A Wunderlich1, S Walser2, B Bartha3, B Brenner3, S Huber4, C Lück2, C Höller4, C Herr3, M Seidel1, and R Niessner1 1- TU München, Institute of Hydrochemistry, Chair of Analytical Chemistry, Munich, DEU; 2TU Dresden, Institute of Medical Microbiology and Hygiene, Institute of Virology, Medical Faculty "C.G. Carus", Dresden, DEU; 3- Occupational and Environmental Health, Epidemiology, Bavarian Health and Food Safety Authority, Munich, DEU; 4- Hygiene, Bavarian Health and Food Safety Authority, Munich, DEU DP 08 Survey of Hepatitis E-Virus in wildlife from military training areas in Germany HE Anheyer-Behmenburg1,2, K Szabo2,3, U Schotte1, A Binder1, R Johne2, and G Klein3 1- Central Institute of the Bundeswehr Medical Service Kiel, Department of Veterinary Medicine, Kronshagen, DEU; 2- Federal Institute for Risk Assessment, Unit Food Hygiene and Virology, Berlin, DEU; 3- University of Veterinary Medicine Hannover, Institute of Food Quality and Food Safety, Hannover, DEU DP 09 Distribution of Leptospira spp. in rodents and other small mammals from Afghanistan A Mayer-Scholl1, RG Ulrich2, JP Teifke3, N Huber2, E Luge1, and K Nöckler1 1- Federal Institute for Risk Assessment (BfR), Department for Biological Safety, Berlin, DEU; 2- Friedrich-Loeffler-Institut (FLI), Institute for Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, DEU; 3- Friedrich-Loeffler-Institut (FLI), Department of Experimental Animal Facilities and Biorisk Management, Greifswald-Insel Riems, DEU DP 10 Differentiation of the bacterial living and non-living community in the heterogeneous matrices of spices and herbs M Kruse1, N Lehmker2, S Schirmer2, and B Niederwöhrmeier2 1- Bundeswehr Research Institute for Protective Technologies and NBC Protection, Biological Lab, Munster, DEU; 2- Bundeswehr Research Institute for Protective Technologies and NBC Protection, B-Detection, Munster, DEU DP 11 Characteristics of S. typhi carrier status of the people who have recovered from typhoid fever in the environment of uranium biogeochemical areas R Toichuev1, N Mambetov2, and A Aitikeeva3 1- Institute of Medical Problems, National Academy of Sciences, Osh, KGZ; 2- Mayluusuu Sanitary and Epidemiological Control Center, Mayluusuu, KGZ; 3- Nooken Sanitary and Epidemiological Control Center, Nooken, KGZ DP 12 The social status of people infected with anthrax in southern region of the Kyrgyz Republic S Zholdoshov1, R Toichuev1, and A Lapushkin1 Institute of Medical Problems, National Academy of Sciences, Osh, KGZ Medical Biodefense Conference 2016 DP 13 Analysis of the broad host range siphovirus BiPBO1 from B. inopinata JA Hammerl, C Goellner, S Al-Dahouk, K Noeckler, J Reetz, and S Hertwig Federal institute for Risk Assessment, Biological Safety, Berlin, DEU DP 14 A novel Brucella species isolated from a dog in Costa Rica MS Zygmunt1,2, M Gonnet1,2, HC Scholz3, G Vergnaud4, and A Cloeckaert1,2 1- INRA, Nouzilly, FRA; 2- Université Francois Rabelais de Tours, UMR1282 Infectiologie et Santé Publique, Tours, FRA; 3- Bundeswehr Institute of Microbiology, Munich, DEU; 4CNRS, Orsay, FRA DP 15 A beaver deceased from tularemia and a high and novel genetic diversity of Francisella tularensis in Germany K Heuner1, C Schulze2, K Myrtennäs3, D Jacob1, E Karlsson3, K Große4, P Kutzer2, M Forsman3 and R Grunow1 1- Centre for Biological Threats and Special Pathogens (ZBS 2), Robert Koch Institute, Berlin, DEU; 2- Landeslabor Berlin-Brandenburg, Frankfurt (Oder), DEU; 3- CBRN Defence and Security, Swedish Defence Research Agency (FOI), Umea, SWE; 4- Gesundheits- und Veterinäramt Stadt Brandenburg, Brandenburg an der Havel, DEU. DP 16 Screening of heroin for Bacillus anthracis-contamination B Ahrens1, G Grass2, L Dobrzykowski2, M Wagner3, C Krüger3, U Schleenbecker1, and R Wölfel2 1- Federal Criminal Police Office, Forensic Science Institute, Wiesbaden, DEU; 2Bundeswehr Institute of Microbiology, Bacteriology and Toxinology, Munich, DEU; 3Bundeswehr Institute of Microbiology, Medical Bio Reconnaissance and Verification, Munich, DEU DP 17 Decontamination control of chemical warefare agents (CWA) by using protein biomarkers A Kostevic, T Meißner, and B Hülseweh Bundeswehr Research Institute, Biological Laboratory, Munster, DEU DP 18 The enemy of my enemy is my friend. Bacillus anthracis specific bacteriophages A Otter1, J Blaxland2, and LW Baillie2 1- Royal Veterinary College, University of London, Department of Pathology & Pathogen Biology, London, GBR; 2- Cardiff University, School of Pharmacy and Pharmaceutical Science, Cardiff, GBR DP 19 In vivo Hemostasis Performance of Chitosan Bandage Using Swine Model Y Kuo1 and T Lin2 1- CoreLeader Biotech Co., Ltd, Regulatory and R&D, Taipei, TWN; 2- National TWN University Hospital, Traumatology, Taipei, TWN DP 20 Survey for zoonotic pathogens in Norway rat populations from Europe E Heuser1, S Fischer1, R Ryll1, A Mayer-Scholl2, D Hoffmann3, C Spahr4, C Imholt5, DM Alfa1, A Fröhlich6, D Lüschow7, R Johne4, B Ehlers8, S Essbauer9, K Nöckler2, and RG Ulrich1 1- Friedrich-Loeffler-Institute, Institute for Novel and Emerging Infectious Diseases, 33 Poster Presentations DP Biological Protection and Environmental Hazards Greifswald, DEU; 2- Federal Institute for Risk Assessment, Department for Biological Safety, Berlin, DEU; 3- Friedrich-Loeffler-Institute, Institute of Diagnostic Virology, Greifswald, DEU; 4- Federal Institute for Risk Assessment, NRL for Monitoring Bacteriological and Viral Contamination of Bivalve Molluscs, Berlin, DEU; 5- Julius KühnInstitute, Institute for Plant Protection in Horticulture and Forests, Münster, DEU; 6Friedrich-Loeffler-Institute, Institute of Epidemiology, Greifswald, DEU; 7- Freie Universität Berlin, Department of Veterinary Medicine, Institute of Poultry Diseases, Berlin, DEU; 8Robert Koch-Institute, Berlin, DEU; 9- Bundeswehr Institute of Microbiology, Munich, DEU 34 DP 21 The changing faces of Bacillus anthracis in soil M Sahin1, C Cooper2, F Büyük3, Ö Celebi3, E Celik3, A Gülmez Saglam3, S Otlu3, and L Baillie4 1- Kafkas University, Department of Microbiology, Veterinary Faculty, Kars, TUR; 2University, Stockholm, The Wenner-Gren Institute, Department of Molecular Biosciences, Stockholm, SWE; 3- Kafkas University, Department of Microbiology, Veterinary Faculty, Kars; 4- Cardiff University, Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, GBR DP 22 The effect of relief peculiarities on the spread of B. anthracis in Jalal-Abad Province of the Kyrgyz Republic R Toichuev1, S Zholdoshov1, N Toichuev1, L Zhilova1, A Lapushkin1, A Aitikeeva2, and N Mambetov3 1- Institute of Medical Problems, National Academy of Sciences, Osh, KGZ; 2- Nooken Sanitary and Epidemiological Control Center, Nooken, KGZ; 3- Mayluusuu Sanitary and Epidemiological Control Center, Mayluusuu, KGZ EP Emerging Zoonotic Infections EP 01 Inhomogeneous distribution of Puumala virus in South-West Germany S Drewes1, H Turni2, UM Rosenfeld1, A Obiegala3, P Straková1, C Imholt4, E Glatthaar5, K Dressel6, M Pfeffer3, J Jacob4, C Wagner-Wiening7, and RG Ulrich1 1- Friedrich-Loeffler-Institut, INNT, Greifswald - Insel Riems, DEU; 2- Stauss & Turni Gutachterbüro, Tübingen, DEU; 3- University Leipzig, Veterinärmedizinische Fakultät, Institut für Tierhygiene und Öffentliches Veterinärwesen, Leipzig, DEU; 4- Julius KühnInstitute, Federal Research Centre for Cultivated Plants, Institute for Plant Protection in Horticulture and Forests, Vertebrate Research, Münster, DEU; 5- Universität Freiburg, Forstzoologisches Institut, Arbeitsbereich Wildtierökologie und Wildtiermanagement, Freiburg, DEU; 6- sine-Institut gGmbH, Munich, DEU; 7- Landesgesundheitsamt BadenWürttemberg, Referat 95 - Epidemiologie und Gesundheitsberichterstattung, Sachgebietsleitung: Infektionsepidemiologische Meldesysteme (SG4), Stuttgart, DEU Advanced training session by the Center for Infection Medicine Munich (CIMM) Medical Biodefense Conference 2016 EP 02 Zoonotic Parapoxvirus infection associated with game animals in the Tyrol region of Austria and Italy HP Huemer1, A Zobl2, A Windisch2, W Glawischnig3, N Romani4, M Büttner5, and M Kitchen4 1- AGES- Austr.Agency f.Health & Food Sefety, IMED, Vienna, AUT; 2- Med.U.Innsbruck, Hygiene/Microbiology, Innsbruck, AUT; 3- AGES, Inst.f.Vet.Med., Innsbruck, AUT; 4Med.U.Innsbruck, Dermatology, Innsbruck, AUT; 5- LGL-Bavarian Health and Food Safety Authority, Dpt.Animal Health, Oberschleissheim, DEU EP 03 Monitoring of shrew-borne Seewis hantavirus in Germany MM Dafalla FLI, Institute of Novel and Emerging Infectious Diseases (INNT), Greifswald, DEU EP 04 Horses and dogs sentinels of West Nile virus circulation in Chad JL Marié1, B Davoust2, M Maquart3, O Carette4, and I Leparc-Goffart3 1- Working Group on Animal Epidemiology, Regional Medical Command, Toulon, FRA; 2Research Unit on Emerging Infectious and Tropical Diseases (URMITE), Marseille, FRA; 3Centre National de Référence des Arbovirus, Equipe Résidente de Recherche en Infectiologie Tropicale (ERRIT), Institut de recherche Biomédicale des Armées, Marseille, FRA; 4- Antenne vétérinaire de Paris, Garde Républicaine, Paris, FRA EP 05 Life-Threatening Dobrava-Belgrade Virus Infections in Europe DH Kruger1, EA Tkachenko2, VG Morozov3, YV Yunicheva4, OM Pilikova5, G Malkin2, AA Ishmukhametov2, P Heinemann1, PT Witkowski1, B Klempa1, and TK Dzagurova2 1- Charité School of Medicine, Virology, Berlin, DEU; 2- Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, RUS; 3- Medical State University, Samara, RUS; 4- AntiPlague Stations, Sochi, RUS; 5- Anti-Plague Stations, Novorossiysk, RUS EP 06 Infection of Human Pulmonary Cells with Old World Hantaviruses A Müller1, A Baumann1, S Essbauer2, M Zeier1, and E Krautkrämer1 1- University of Heidelberg, Department of Nephrology, Heidelberg, DEU; 2- Bundeswehr Institute of Microbiology, Department of Virology & Rickettsiology, Munich, DEU FP Next Generation Sequencing Approaches FP 01 Whole genome sequence analysis suggests that a remarkable expansion of Bacillus anthracis occurred in France during the Hundred Years War with England G Vergnaud1, G Girault2, S Thierry2, C Pourcel1, N Madani2, and Y Blouin3 1- University Paris-Saclay, I2BC, Orsay, FRA; 2- University Paris-Est, ANSES, MaisonsAlfort, FRA; 3- DGA, NRBC, Vert-le-Petit, FRA FP 02 3rd generation long read sequencing as basis for human diagnostics M Droege Roche Diagnostics International Ltd., Rotkreuz, CHE 35 Poster Presentations 36 FP Next Generation Sequencing Approaches FP 03 MinIONTM-Sequencing– A new approach for rapid diagnostics in the field? MH Antwerpen, E Georgi, P Vette, GH Genzel, and M Walter Bundeswehr Institute of Microbiology, Munich, DEU FP 04 Identification of pathogen sequences in NGS datasets A Andrusch1, PW Dabrowski2, J Klenner1, and A Nitsche1 1- Robert Koch Institute, ZBS 1 - Centre for Biological Threats and Special Pathogens: Highly Pathogenic Viruses, Berlin, DEU; 2- Robert Koch Institute, JRG 4 - Junior Research Group: Bioinformatics, Berlin, DEU FP 05 Separation of foreground and background reads in mixed NGS datasets S Tausch1, BY Renard2, A Nitsche1, and PW Dabrowski2 1- Robert Koch Institute, ZBS 1 - Centre for Biological Threats and Special Pathogens: Highly Pathogenic Viruses, Berlin, DEU; 2- Robert Koch Institute, JRG 4 - Junior Research Group: Bioinformatics, Berlin, DEU FP 06 Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus RNA Strains from South Kazakhstan P Deryabin1, Y Sansyzbayev1, T Nurmakhanov1, V Berezin2, A Shevtsov3, A Vilkova1, O Yeskhojayev1, R Sailaubekuly1, M Kulyomin1, and L Atovulayeva1 1- M. Aikimbayev Kazakh Scientific Center of Quarantine and Zoonotic Diseases, Almaty, KAZ; 2- Institute of Microbiology and Virology, Almaty, KAZ; 3- National Center for Biotechnology, Astana, KAZ FP 07 Genotyping of Brucella species by SNPs analysis M Ancora1, R De Santis2, A Anselmo2, M Orsini1, F De massis1, S Fillo2, K Zilli1, A Fortunato2, A Palozzi2, B Gentile2, A Ciammaruconi2, E Di Giannatale1, C Cammà1, and F Lista2 1- Istituto Zooprofilattico Sperimentale Teramo, Teramo, ITA; 2- Centro Studi e Ricerche di Sanità e Veterinaria Esercito Italiano, Roma, ITA FP 08 Assessing congruence in SNP genotypes determined from CLC Genomics Workbench and Life Technologies HID SNP Genotyper KA Meiklejohn, and JM Robertson FBI Laboratory, CFSRU, Quantico, VA, USA FP 09 16S Metagenomics for Identification of Bacterial Genotypes in Voles KA Koskela1, L Kalin-Mänttäri1, H Hemmilä1, PM Kinnunen2, P Auvinen3, J Niemimaa4, H Henttonen4, and S Nikkari1 1- Centre for Military Medicine, Research and Development Department, Helsinki, FIN; 2Finnish Defence Forces, Defence Command FIN, Helsinki, FIN; 3- University of Helsinki, Institute of Biotechnology, Helsinki, FIN; 4- Natural Resources Institute FIN, Vantaa, FIN Medical Biodefense Conference 2016 FP 10 Genome-wide comparison of Cowpox viruses reveals a new clade related to Variola virus L Schrick1, PW Dabrowski1, A Radonić1, A Kurth2, and A Nitsche1 1- Robert Koch Institute, Centre for Biological Threats and Special Pathogens 1 - Highly Pathogenic Viruses, Berlin, DEU; 2- Robert Koch Institute, Centre for Biological Threats and Special Pathogens 5 - Biosafety Level 4 Laboratory, Berlin, DEU FP 11 Bioinformatic search and screening of phages and plasmids via spacer sites of Yersinia pesudotuberculosis YPIII CRISPR/CAS System FP Peretolchina1, YP Dzhioev1, AY Borisenko1, AI Paramonov1, EA Voskresenskaya2, LA Stepanenko1, NE Zelinskaya1, OV Kolbaseeva 1, and VI Zlobin1 1- Irkutsk State Medical University, Irkutsk, RUS, Irkutsk, RUS; 2- Pasteur Institute of Epidemiology and Microbiology, Saint-Petersburg, RUS, Saint-Petersburg, RUS FP 12 Whole genome core gene typing of Bacillus anthracis MC Walter, G Grass, and MH Antwerpen Bundeswehr Institute of Microbiology, Munich, DEU FP 13 Whole genome analysis of endospore-forming bacteria isolated from heroin J Kalinowski1, L Dobrzykowski2, B Ahrens3, A Winkler1, A Al-Dilaimi1, D Wibberg1, M Wagner4, U Schleenbecker3, R Wölfel2, and G Grass2 1- Bielefeld University, Center for Biotechnology, Bielefeld, DEU; 2- Bundeswehr Institute of Microbiology, Bacteriology and Toxinology, Munich, DEU; 3- Federal Criminal Police Office, Forensic Science Institute, Wiesbaden, DEU; 4- Bundeswehr Institute of Microbiology, Medical Bio Reconnaissance and Verification, Munich, DEU GP Strategies for Preparedness and Management GP 01 The German Academy for Crisis Management, Emergency Planning and Civil Protection – a nationally and internationally recognized CBRN Training Center MV Weber, G Uelpenich, J Kaempen, and D Friedrich Federal Office of Civil Protection and Disaster Assistance, Academy for Crisis Management, Emergency Planning and Civil Protection, Bad Neuenahr – Ahrweiler, DEU GP 02 Comparison of NATO AMedP-7.5 Biological Casualty Estimates CA Curling, and SM Oxford Institute for Defense Analyses, Strategy, Forces and Resources Division, Alexandria, VA, USA GP 03 Open Source Tools for the Assessment of Compliance with the BWC M Himmel, and G Jeremias Research Group for Biological Arms Control, University of Hamburg / ZNF, Hamburg, DEU 37 Poster Presentations 38 GP Strategies for Preparedness and Management GP 04 Animal sentinel systems for biohazard risk assessment in French armed forces S Watier-Grillot1, B Davoust2, J Demoncheaux3, R Michel1, and J Marié4 1- Army Center for Epidemiology and Public Health Center, Health surveillance, Marseille, FRA; 2- University of Aix-Marseille - Faculty of Medicine, Research Unit of Emerging Infections and Tropical Diseases - UMR CNRS 7278 IRD 198 INSERM 1095, Marseille, FRA; 3- Central Direction of French Army Health Service, Health operational headquarters, Paris, FRA; 4- Regional Direction of French Army Health service, Working group on Animal Epidemiology, Toulon, FRA GP 05 The US European Command Counter Bio-Threats Cell JA Steele, and KC Allen U.S. European Command, Counter Bio-Threats Cell, Stuttgart, DEU GP 06 Food defense concept and application to French army S Watier-Grillot1, J Demoncheaux2, R Lamand3, R Michel1, and O Cabre4 1- Army Center for Epidemiology and Public Health Center, Health surveillance, Marseille, FRA; 2- Central Direction of French Army Health Service, Health operational headquarters, Paris, FRA; 3- French Army Health Service, Veterinary Public Health Unit, Paris, FRA; 4Technical Inspectorate of French Army Veterinary Services, Quality Cell, Paris, FRA GP 07 RIGEL: Analysis System for Microbial Attribution, Bioforensics and Biosurveillance WA Valdivia-Granda Orion Integrated Biosciences, New York, USA GP 08 Quality Assurance of BSL3 laboratory capacity in Sweden T Boskani1, M Granberg2, S Frosth3, S Bereczky1, and C Flink4 1- Public Health Agency of SWE, Stockhom, SWE; 2- Swedish Defence Research Agency, Umeå, SWE; 3- National Veterinary Institute, Uppsala, SWE; 4- National Food Agency, Uppsala, SWE GP 09 The European Network on Highly Pathogenic Infectious Agents R Grunow1, A Di Caro2, D Jacob1, C Nisii2, A Rohleder1, and G Ippolito2 on behalf of the EMERGE partners3 1- Robert Koch Institute, Centre for Biological Threats and Special Pathogens (ZBS 2), Berlin, DEU; 2- Spallanzani National Institute for Infectious Diseases, Virology Department, Rome, ITA; 3- http://www.emerge.rki.eu, EU, EU GP 10 Joint Action EMERGE: Efficient response to highly dangerous and emerging pathogens at EU level D Jacob1, A Sandra1, A Di Caro2, C Nisii2, B Bartolini2, A Rohleder1, G Ippolito2, and R Grunow1 on behalf of the EMERGE partners3 1- Robert Koch-Institut, Centre for Biological Threats and Special Pathogens, Highly Pathogenic Microorganisms (ZBS 2), Berlin, DEU; 2- L. Spallanzani National Institute for Infectious Diseases, Virology Department, Rome, ITA; 3- http://www.emerge.rki.eu, EU, EU Medical Biodefense Conference 2016 GP 12 New approaches and new intentions against biological attacks⁄threats V Radosavljevic1,2, and G Belojevic3 1- Military Academy, University of Defense, Belgrade, SRB; 2- Medical Corps Headquarters, Ministry of Defence, Belgrade, SRB; 3- University of Belgrade, Institute of Hygiene and Medical Ecology, Belgrade, SRB GP 13 Strengthening Health and Biosecurity in Tanzania by Biodetection Capacity Building A Katz1, Z Makondo2, J Masambu2, F Mramba2, and S Nikkari1 1- Center for Biothreat Preparedness and for Military Medicine, Finnish Defence Forces, Helsinki, FIN; 2- TZA Veterinary Laboratory Agency, Ministry of Agriculture, Livestock and Fisheries, Dar es Salaam, TZA GP 14 National Brucella strain collection maintenance standard development accordance with the European requirements for biosafety and biosecurity BT Stegniy1, OV Obukhovska2, AP Gerilovych3, AI Zavgorodniy2, and MS Mandygra1 1- NSC IECVM, Kharkiv, UKR; 2- NSC IECVM, Brucellosis and tuberculosis, Kharkiv, UKR; 3- NSC IECVM, Molecular Epidemiology, Kharkiv, UKR GP 15 International cooperation helps to reduce biological threats NT Usenbaev, and AK Dzhaparova The Center of Quarantine and Especially Dangerous Infections, Bishkek, KGZ HP Interactive Voting Session - Case Reports Advanced training session by the Center for Infection Medicine Munich (CIMM) and the German Society for Military Medicine and Pharmacy HP 01 Update from the German Brucella reference laboratory M Pfalzgraf, B Thoma, P Vollmar, H Scholz, L Zöller, and S Zange Bundeswehr Institute of Microbiology, Munich, DEU HP 02 Plague suspected case in Aktobe Region of Kazakhstan 2014 AM Dmitrovskiy1, AZ Murzagaliyeva2, GD Zhumagaliyeva3, MS Kurmangazin2, IN Musabekova3, and ZE Bekenov4 1- Kazakh National Medical University, Infectious Diseases, Almaty, KAZ; 2- Western-KAZ Medical University, Epidemiology, Aktobe, KAZ; 3- Western-KAZ Medical University, Pediatric Infectious Diseases, Aktobe, KAZ; 4- Aktobe Anti Plague Station, Aktobe, KAZ HP 03 Coxiella burnetii infection in Latvia in 2012-2015 J Storozenko1, T Kolupajeva1, G Pakarna1, N Zamjatina1, A Drabovics1, B Rozentale2, and A Brila3 1- Latvian Center of Infectious Diseases, National Microbiology Reference Laboratory, Riga, LVA; 2- Latvian Center of Infectious Diseases, Riga, LVA; 3- The Centre for Disease Prevention and Control of Latvia, Epidemiology, Riga, LVA HP 04 Clinical characteristics of anthrax disease in southern region of the Kyrgyz Republic S Zholdoshov Institute of Medical Problems, National Academy of Sciences, Osh, KGZ 39 Poster Presentations HP 40 Interactive Voting Session - Case Reports Advanced training session by the Center for Infection Medicine Munich (CIMM) and the German Society for Military Medicine and Pharmacy HP 05 A complicated Pneumonic Plague with MDR-bacterial Co-Infection in Madagascar V Andrianaivoarimanana1, E Bertherat2, C Rogier3, and M Rajerison1 1- Institut Pasteur de Madagascar, Plague Unit, Antananarivo, MDG; 2- World Health Organization, Department of Pandemic and Epidemic Diseases, Geneva, CHE; 3- Institut Pasteur de Madagascar, Antananarivo, MDG HP 06 Probable case of Hanta Virus Infection (Hemorrhagic Fever with Renal Syndrome) in Aktobe Region of Kazakhstan, 2015 AM Dmitrovskiy1, MS Kurmangazin2, IN Musabekova2, AZ Murzagaliyeva3, ZE Bekenov4, and MG Nurgaliyeva5 1- Kazakh National Medical University, Infectious Diseases, Almaty, KAZ; 2- Western-KAZ Medical University, Infectious diseases, Aktobe, KAZ; 3- Western-KAZ Medical University, Epidemiology, Aktobe, KAZ; 4- Aktobe Anti Plague Station, Aktobe, KAZ; 5- Aktobe Infectious Hospital, Aktobe, KAZ HP 07 Severe Outbreak amongst Soldiers caused by Salmonella JM Riehm1, P Simoes2, M Hergenroether1, J Oltersdorf3, U Messelhaeuser4, W Rabsch5, P Joo6, and S Sauer1 1- Central Institute of the Bundeswehr Medical Service, Bacteriology, Munich, DEU; 2- POR military, Lissabon, PRT; 3- Central Institute of the Bundeswehr Medical Service, Bacteriology, Mainz, DEU; 4- Landesuntersuchungsamt Bayern, Munich, DEU; 5- RobertKoch Institute, Wernigerode, DEU; 6- HUN military, Budapest, HUN IP Outbreak Management: “Ready or Not - Here I Come“ IP 01 Field investigation of arboviruses in Australia TJ Inglis1, AJ Merritt1, and A Levy2 1- University of Western AUS, School of Pathology & Laboratory Medicine, Crawley, AUS; 2 - PathWest Laboratory Medicine, Department of Microbiology, Nedlands, AUS IP 02 CCHF Exposure of Healthcare Professionals in Turkey; How Could We Use This Experience For Ebola? S Sezigen1, K Eyison1, L Kenar1, and A Oztuna2 1- GMMA Institýte of Health Sciences, Medical CBRN Defense, Ankara, TUR; 2- GMMA, Medical Genetics, Ankara, TUR IP 03 Field based multiplex detection of biothreat agents C Pöhlmann, and T Elßner Bruker Daltonik GmbH, Application CBRNE, Leipzig, DEU IP 04 The mobile suitcase laboratory: A tool for the rapid detection of emerging and endemic infectious disease A Abd el Wahed1, P Patel2, O Faye3, MA Shalaby4, M Niedrig5, C Czerny1, AA Sall3, FT Hufert6, and M Weidmann7 Medical Biodefense Conference 2016 1- Georg-August-University, Division of Microbiology and Animal Hygiene, Goettingen, DEU; 2- TIB MOLBIOL Syntheselabor GmbH, Berlin, DEU; 3- Pasteur Institute, Arbovirus unit, Dakar, Senegal; 4- Cairo University, Faculty of Veterinary Medicine, Department of Virology, Giza, Egypt; 5- Robert Koch Institute, Berlin, DEU; 6- Brandenburg Medical School Fontane, Senftenberg, DEU; 7- University of Stirling, Institute of Aquaculture, Stirling, Scotland, GBR IP 05 After Ebola: Moving forward on preparedness for unusual disease outbreaks I Hunger Robert Koch Institute, ZBS, Berlin, DEU IP 06 Verification of the mobile qPCR device Razor Ex ("The 10®" Pouch) K Keeren1, T Muzeniek1, S Lenerz2, R Grunow3, D Brigitte4, and A Nitsche1 1- Robert Koch-Institute, ZBS 1, Berlin, DEU; 2- Federal Office of Civil Protection and Disaster Assistance, Bonn, DEU; 3- Robert Koch-Institute, ZBS 2, Berlin, DEU; 4- Robert Koch-Institute, ZBS 3, Berlin, DEU IP 07 CBRN Sampling Equipment - From Research via development to practical training – an integrative approach G Uelpenich1, and N Derakshani2 1- Federal Office of Civil Protection and Disaster Assistance, Academy for Crisis Management, Emergency Planning and Civil Protection, Bad Neuenahr - Ahrweiler, DEU; 2Federal Office of Civil Protection and Disaster Assistance, Bonn, DEU IP 08 Assessing the Impact of Emerging Infectious Diseases on Military Operations JK Burr, and RL Cubeta Institute for Defense Analyses, Strategy, Forces, and Resources Division, Alexandria, Virginia, USA IP 09 Assessment of risks of infection of people and animals at contact with natural (the soil foci) or artificial (laboratory) of anthrax reservoirs L Lukhnova, A Bakhyt, L Nekrassova, T Meka-Mechenko, V Kazakov, U Izbanova, and V Sushchikh The Kazakh Scientific Center of Quarantine and Zoonotic Diseases named after Masgut Aikimbaev,Almaty, KAZ ´ IP 10 The EFFO project: Linking micro and macro levels to prepare health care workers (HCW) for outbreak situations by transcultural training and networking L Verbeek1, P Kabore2, M Mendy3, R Kabore2, R Ellwanger1, Z Kolobaric1, and S Gies4 1- Robert Koch Institute, Centre for Biological Threats and Special Pathogens, Berlin, DEU; 2- OCADES Caritas Burkina, Ouagadougou, BFA; 3- Association Nationale des Postes de Santé Catholique du Sénégal (ANPSCS), Dakar, SEN; 4- Medical Mission Institute Würzburg, Würzburg, DEU 41 Poster Presentations 42 JP Diagnostics - “Sherlock“ at his best JP 01 Compact Systems for Automated Enrichment and Detection of Biothreats at Point-ofuse R Himmelreich, M Bassler, R Gransee, C Schwindt, and K Potje-Kamloth Fraunhofer ICT-IMM, Analytics and Sensorics, Mainz, DEU JP 02 Ebolavirus proficiency test within the National Laboratory Network for Diagnostics of BT-relevant Agents (NaLaDiBA) K Keeren1, S Becker2, S Günther3, H Ellerbrok1, M Panning4, M Eiden5, J SchmidtChanasit3, M Eickmann2, M Monazahian6, B Hülseweh7, B Thoma8, R Oehme9, and A Nitsche1 1- Robert Koch-Institute, ZBS 1, Berlin, DEU; 2- Institute of Virology, Philipps University, Marburg, DEU; 3- Bernhard Nocht Institute, Hamburg, DEU; 4- University Hospital, Virology, Freiburg, DEU; 5- Friedrich Loeffler Institute, Greifswald, Island of Riems, DEU; 6- Lower Saxony State Health Office, Hannover, DEU; 7- Bundeswehr Research Institute for Protective Technologies and NBC Protection (WIS), Munster, DEU; 8- Bundeswehr Institute of Microbiology, Munich, DEU; 9- Baden-Württemberg State Health Office, Stuttgart, DEU JP 03 Rapid, Reliable and Easy On-Site Identification of Biological Threats S Ziewer-Arndts analyticon instruments Gmbh, Rosbach, DEU JP 04 A comparison of fluorescence in situ hybridization and quantitative RT-PCR for the detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis S Mantel1, K Aistleitner1, K Stoecker2, and R Wölfel1 1- InstMikroBioBw, Division for Bacteriology and Toxinology, Munich, DEU; 2InstMikroBioBw, Department for Med. Bio Reconnaissance and Verification, Munich, DEU JP 05 Validation of a novel Bacillus anthracis PCR Kit within the National Laboratory Network for Diagnostic of BT-relevant Agents (NaLaDiBA) K Keeren1, S Ölschläger2, M Elschner3, S Klee4, B Hülseweh5, R Konrad6, G Grass7, M Monazahian8, R Oehme9, and A Nitsche1 1- Robert Koch-Institute, ZBS 1, Berlin, DEU; 2- altona Diagnostics GmbH, , Hamburg, DEU; 3- Friedrich Loeffler Institute, Jena, DEU; 4- Robert Koch-Institute, ZBS 2, Berlin, DEU; 5- Bundeswehr Research Institute for Protective Technologies and NBC Protection (WIS), Munster, DEU; 6- Bavarian Health and Food Safety Authority, Oberschleißheim, DEU; 7- Bundeswehr Institute of Microbiology, Munich, DEU; 8- Lower Saxony State Health Office, Hannover, DEU; 9- Baden-Württemberg State Health Office, Stuttgart, DEU JP 06 An microarray-based platform for the multiplexed analysis of immunoprofiles for early differential diagnosis of infectious diseases R Sekul PEPperPRINT GmbH, F&E, Heidelberg, DEU Medical Biodefense Conference 2016 JP 07 Development of a real time microwave-enhanced rapid (~5 minutes) detection assay for genomic Bacillus anthracis LT Joshi1, J Lees2, A Porch2, R Probert1, T Connor3, and L Baillie1 1- Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff, GBR; 2Cardiff University, School of Engineering, Cardiff, GBR; 3- Cardiff University, School of Biosciences, Cardiff, GBR JP 08 Using rapid diagnostics to identify causes of febrile illnesses other than Ebola Virus Disease at a military Ebola Treatment Unit in Sierra Leone MK Oshea1, K Clay1, T Fletcher1, M Bailey1, and E Hutley2 1- Royal Centre for Defence Medicine, Academic Department of Military Medicine, Birmingham, GBR; 2- Royal Centre for Defence Medicine, Centre for Defence Pathology, Birmingham, GBR JP 09 Influence of different blood collection tubes on virus diagnostics J Klenner, C Kohl, and A Nitsche Robert Koch Institute, ZBS 1 - Highly Pathogenic Viruses, Berlin, DEU JP 10 Rapid detection of viral infections by use of a novel optical biosensor technology D Vollandt1, P Patel1, P Prüger1, G Proll1, F Pröll2, and M Niedrig1 1- Robert Koch Institute, Center for Biological Threats and Special Pathogens 1, Highly Pathogenic Viruses, Berlin, DEU; 2- Biametrics GmbH, Tübingen, DEU JP 11 Rapid detection of ESBL-producing bacteria in irrigation water by DNA microarrays S Schaefer1, G Valenza2, D Calomfirescu3, S Huber3, C Höller3, R Niessner1, and M Seidel1 1- Technical University of Munich, Chair of Analytical Chemistry and Institute of Hydrochemistry, Munich, DEU; 2- Bavarian Health and Food Safety Authority, Erlangen, DEU; 3- Bavarian Health and Food Safety Authority, Oberschleissheim, DEU JP 12 Prepared for the unusual – fast exchange of database entries for strengthening MALDI-TOF MS diagnostics on the example of Streptobacillus J Rau1, and T Eisenberg2 1- Chemisches und Veterinäruntersuchungsamt Stuttgart, Fellbach, DEU; 2- Landesbetrieb Hessisches Landeslabor, Gießen, DEU JP 13 Using MALDI-TOF for Genetically Altered Vibrio cholerae Elitor Variants Detection ZY Khunkheeva1, LV Mironova1, SV Balakhonov2, and MV Afanasev1 1- Irkutsk Antiplague Research Institute of Rospotrebnadzor, Laboratory of Cholera, Irkutsk, RUS; 2- Irkutsk Antiplague Research Institute of Rospotrebnadzor, Microbiological Department, Irkutsk, RUS; 3- Irkutsk Regional Clinical Advisory-Diagnostic Centre, Department of Laboratory Diagnostics, Irkutsk, RUS JP 14 Performance evaluation of an IgG capture and an IgM µ-capture Chikugunya ELISA with regards to different strains and regions H Duchmann, and C Flechsig NovaTec Immundiagnostica GmbH, Dietzenbach, DEU 43 Poster Presentations 44 JP Diagnostics - “Sherlock“ at his best JP 15 Verification and Validation of three RealStar® RT-PCR Kits for Parallel Detection of Zika, Chikungunya and Dengue Virus M Zaruba, H El Halas, M Hess, and S Ölschläger altona Diagnostics GmbH, Research and Development, Hamburg, DEU JP 16 Species-specific differentiation of variola, monkeypox, and varicella-zoster viruses by multiplex real-time PCR assay RA Maksyutov, EV Gavrilova, and SN Shchelkunov State Research Center of Virology and Biotechnology VECTOR, Koltsovo, RUS JP 17 Comparison of four commercial DNA extraction kits for the recovery of Bacillus thuringiensis spore DNA from spiked powder samples M Mölsä1, L Kalin-Mänttäri2, E Tonteri1, H Hemmilä1, and S Nikkari1 1- Centres for Military Medicine and for Biological Threat Preparedness, Helsinki, FIN; 2National Institute for Health and Welfare, Helsinki, FIN JP 18 Molecular tools for the discrimination among homogeneous pathogens: example of anthrax, brucellosis and tularemia G Girault, N Madani, M Jay, C Mendy, C Ponsart, and V Mick ANSES, Animal Health Laboratory, Maisons-Alfort, FRA JP 19 Implementation of New Diagnostic Immunoassays for Detection of F. tularensis and Brucella species in the Country of Georgia M Chubinidze1, L Johnson2, B Jenkins2, J Czarnecki2, and S Tsanava1 1- National Center for Disease Control and Public Health, Tbilisi, GEO; 2- Naval Medical Research Center, Frederick, USA JP 20 Point-of-Need Detection of Biological Threats T van Oordt, O Strohmeier, K Mitsakakis, S Hin, R Zengerle, and F von Stetten Hahn-Schickard, Freiburg, DEU JP 21 Discovery of Host Biomarkers for Early Diagnosis of Biological Agents K Willis1, D Donohue2, R Yang3, S Muhie3, R Hammamieh2, M Jett-Templeton2, and S Ibrahim1 1- Edgewood Chemical Biological Center, Aberdeen Proving Ground, US; 2- U.S. Army Center for Environmental Health Research, Frederick, US; 3- The Geneva Foundation, Frederick, US JP 22 Fast and on-site detection of F. tularensis and Y. pestis with commercial ready-to-use assays N Sparding, G Kristiansen, MB Oleksiewicz, NR Steenhard, and KN Olsen Centre for Biosecurity and Biopreparedness , Statens Serum Institut, Copenhagen, DNK Medical Biodefense Conference 2016 JP 23 A Selective Solid Growth Medium for Isolating and Differentiating Francisella tularensis Type A and B subspecies A Shea, T Abshire, M Wolcott, and D Rozak USAMRIID, DSD, Frederick, USA JP 24 Diagnostic SNP-based system for the differentiation of Y. pestis ssp pestis and Y. pestis ssp pestoides in real time PCR A Trukhachev1, N Konovalova2, A Vodopianov1, K Blagodatskikh2, D Kuznetsova1, D Sochivko3, and A Rakin4 1- Antiplague Research Institute, Microbiology of Yersinia pestis, Rostov-on-Don, RUS; 2Antiplague Research Institute, Virology, Rostov-on-Don, RUS; 3- Syntol, Biotechnology, Moscow, RUS; 4- Max von Pettenkofer-Institute, Microbiology of Yersinia, Munich, DEU JP 25 Multiplex real-time PCR Assay for the Detection and Differentiation of Poxviruses and Poxvirus Vectors T Stellberger1, I Stockmar1, M Haase1, H Meyer2, G Zoeller2, M Pavlovic1, M Büttner1, R Konrad1, H Lang1, K Tischer3, BB Kaufer3, U Busch1, and A Baiker1 1- Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Gentechnische Anlagen, Oberschleißheim, DEU; 2- Bundeswehr, Institute of Microbiology, Dep Virology, Munich, DEU; 3- FU Berlin, Institute of Virology, Berlin, DEU JP 26 Bacillus cereus spores grown in different media can be differentiated using fatty acid methyl ester (FAME) analysis and Raman spectroscopy JR Dettman1, CJ Ehrhardt2, and JM Robertson1 1- FBI Laboratory, CFSRU, Quantico, VA, USA; 2- Virginia Commonwealth University, Dept. Forensic Sciences , Richmond, VA, USA JP 27 The “who is who” in electron microscopy: establishing techniques for virological diagnostics and applied research S Essbauer, T Hinsel, C Kahlhofer, and J Brohl Bundeswehr Institute of Microbiology, Dept. Virology & intracellular agents, München, DEU JP 28 A new TaqMan-based real-time PCR assay for detection of Yersinia subspecies EN Salomonsson1, P Ågren2, M Wijkander3, J Börjesson4, S Frosth4, J Thelaus 1 and E Karlsson1 1- The Swedish Defence Research Agency, CBRN - Defence and Security, Umeå, SWE; 2The Swedish National Food Agency, Uppsala, SWE; 3- The Swedish National Institute of Public Health, Stockholm, SWE; 4- The National Veterinary Institute, Uppsala, SWE JP 29 Simultaneous identification of biological warefare agents with the BioPlex200-System C Erdmann, and B Hülseweh Bundeswehr Research Institute, Biological Laboratory, Munster, DEU JP 30 Decentralized Molecular Testing — Simplicity Rules A Wende1, C Engemann2, S Werner1, and C Fischer-Rasokat3 1- QIAGEN GmbH, Hilden, DEU; 2- QIAGEN Leipzig GmbH, Leipzig, DEU; 3- QIAGEN Lake Constance GmbH, Stockach, DEU 45 Poster Presentations JP JP 31 Molecular detection of hepatitis C virus in high risk population: the military medical concerns E Ristanovic1,2, S Radakovic1,2, V Protic-Djokic1, S Atanasievska1, and D Jovanovic1 1- Military Medical Academy, Belgrade, SRB; 2- University of Defence, Belgrade, SRB JP 32 Creation of polymerase chain reaction protocol for West Nile fever virus detection AP Gerilovych1, BT Stegniy1, OS Solodiankin1, MY Stegniy2, VI Bolotin1, IO Gerilovych1, and IV Goraichuk1 1- NSC IECVM, Molecular Epidemiology, Kharkiv, UKR; 2- NSC IECVM, Kharkiv, UKR KP 46 Diagnostics - “Sherlock“ at his best Microbial Population Genomics KP 01 Using Full Genome SNP Analysis as a tool to investigate the Epidemiology and Ecology of Bacillus cereus biovar anthracis F Zimmermann1,2, C Hoffmann2, K Nowak1,2, S Dupke1, E Couacy-Hymann3, R Grunow1, S Calvignac-Spencer2, S Klee1, and F Leendertz2 1- Robert Koch-Institute, Centre for Biological Threats and Special Pathogens (ZBS2), Berlin, DEU; 2- Robert Koch-Institute, Epidemiology of highly pathogenic Microorganisms (P3), Berlin, DEU; 3- Laboratoire National d’Appui au Développement Agricole (LANADA)/ Laboratoire Central Vétérinaire de Bingerville (LCVB), Department of Virology, Bingerville, Côte d'Ivoire KP 02 Integrating the Risk Analysis of Brucella infection in Dairy Herds into Herd Management Software A Banai1, and M Banai2 1- Honorary consultant, Helsinki, FIN; 2- Kimron Veterinary Institute, Bacteriology, Bet Dagan 5025001, ISR KP 03 Microevolution from a Young Ancestor (M.A.Y.A.) Suggests a Soil-Borne Life Cycle of Bacillus anthracis P Braun1, G Grass1, M Hanczaruk1, A Aceti2, A Affuso2, V Rondinone2, L Serrechia2, L Marino2, B Northoff3, M Schloter4, E Georgi5, MH Antwerpen5, and A Fasanella2 1- Bundeswehr Institute of Microbiology, Bacteriology and Toxinology, Munich, DEU; 2Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, Anthrax Reference Institute of ITA, Foggia, ITA; 3- Ludwig Maximilians Universität München, Institut für Laboratoriumsmedizin, Munich, DEU; 4- German Research Center for Environmental Health, Research Unit for Environmental Genomics, Neuherberg, DEU; 5- Bundeswehr Institute of Microbiology, Genomics and Bioinformatics, Munich, DEU KP 04 MLVA genotyping of Brucella abortus and Brucella melitensis in Kazakhstan E Shevtsova1, A Shevtsov1, P Tarlykov1, Y Ramankulov1, A Jailbekova2, M Syzdykov3, A Kuznetsov3, A Chsherbakov2, A Kairzhanova1, D Kamalova1, G Abisheva1, S Tyulegenov2, I Sytnik2, T Karibayev2, and M Filipenko4 Medical Biodefense Conference 2016 1- National Center for Biotechnology, Astana, KAZ; 2- National Reference Center for Veterinary, Astana, KAZ; 3- M. Aikimbayev Kazakh Scientific Center of Quarantine and Zoonotic Diseases, Almaty, KAZ; 4- Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, RUS KP 05 Canine brucellosis in Brazil: existence of an autochthonous lineage AF Vicente1, Y Corde1, L Perrot1, MR Mioni2, LB Keid3, VR Salgado4, M Jay1, J Megid2, and V Mick1 1- Paris-Est University/ANSES, Bacterial Zoonoses Unit, Maisons-Alfort, FRA; 2- FMVZ, UNESP, Dep. of Veterinary Hygiene and Public Health, Botucatu, BRA; 3- USP, Dep. of Veterinary Medicine, Pirassununga, BRA; 4- Federal University of Bahia, Salvador, BRA KP 06 Investigation of dog blood samples for the presence of fastidious micro-organisms N Abazashvili1, T Giorgadze1, G Katsitadze1, R Arner2, M Kosoy3, and L Malania1 1- National Center for Disease Control and Public Health, Tbilisi, GEO; 2- Metabiota, Inc., San Francisco, USA; 3- Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, USA KP 07 Epidemiological Features of Human Anthrax Cases in Mongolia K Burmaa1, N Tsogbadrakh1, G Ganbileg1, M Darmaa2, and G Davaa2 1- National center for zoonotic diseases, Ulaanbaatar, MNG; 2- Mongolian National University of Medical Sciences, Ulaanbaatar, MNG KP 08 Unexpected genomic relationships between Bacillus anthracis strains from Bangladesh and central Europe CR Ahsan1, G Grass2, MH Antwerpen3, FI Rume1, and MA Hanczaruk2 1- University of Dhaka, Department of Microbiology, Dhaka, BGD; 2- Bundeswehr Institute of Microbiology, Department for Bacteriology and Toxinology, Munich, DEU; 3Bundeswehr Institute of Microbiology, Department for Microbial Genomics and Bioforensics, Munich, DEU LP Virulence Factors and Pathogenic Mechanisms LP 01 Virulence of emerging Bacillus cereus biovar anthracis is determined by toxins and two types of capsules SR Klee1, S Dupke1, C Brézillon2, M Haustant2, A Lander1, J Corre2, T Franz1, F Zimmermann1, FH Leendertz3, M Mock2, R Grunow1, and PL Goossens2 1- Robert Koch-Institut, Centre for Biological Threats and Special Pathogens (ZBS 2), Berlin, DEU; 2- Institut Pasteur, Pathogénie des Toxi-Infections Bactériennes, Paris, FRA; 3- Robert Koch-Institut, Epidemiology of Highly Pathogenic Microorganisms (P3), Berlin, DEU LP 02 Machine Learning Driven Detection of Bacterial Virulence Factors R Rentzsch, C Deneke, and BY Renard Robert Koch Institut, NG4, Berlin, DEU 47 Poster Presentations 48 LP Virulence Factors and Pathogenic Mechanisms LP 03 Rapid and sensitive Detection of Staphylococcal Enterotoxins by Immunomagnetic separation inline-coupled Microarray analysis A Nistler1, M Sandhu1, R Dietrich2, E Märtlbauer2, T Wittwer3, R Niessner1, and M Seidel1 1- Technical University of Munich, Institute of Hydrochemistry and Chair of Analytical Chemistry , Munich, DEU; 2- Ludwig Maximilians University of Munich, Hygiene and Technology of Milk, Munich, DEU; 3- R-Biopharm AG, Darmstadt, DEU LP 04 Investigations of biological characteristics and patterns of cell death genes during Langat virus infection of neuroblastoma cell lines S Essbauer1, K Freimüller1, A Mayer1, P Vollmar1, S Frey1, G Dobler1, and R Kühn2 1- Bundeswehr Institute of Microbiology, Dept. Virology & intracellular agents, München, DEU; 2- Technical University Munich, AG Molecular Zoology, Freising-Weihenstephan, DEU LP 05 Anthrax pore biology: characterization by neutron scattering and application to cytosolic antisense and siRNA delivery. S Shorter1, P Dyer1, S Richardson1, L Baillie2, and R Barker3 1- University of Greenwich, Life and Sport Science, Chatham Maritime, GBR; 2- Cardiff University, School of Pharmacy & Pharmaceutical Science, Cardiff, GBR; 3- University of Dundee, Dundee, GBR LP 06 Validation of a mass spectrometry (MS) method capable of detecting and measuring the activity of ribosome inactivating proteins (RIPs) in complex food and drink matrices JM Goss, and JM Robertson FBI Laboratory, CFSRU, Quantico, VA, USA LP 07 Novel cell targeting L-ddBCNA antiviral inhibits autophagy in measles virus infected cells R Narayan1, L Farleigh1, D Friese2, C McGuigan3, E Sayers3, AT Jones3, and JJ Bugert1 1- Cardiff University, Medical Microbiology and Infectious Diseases, Cardiff, GBR; 2Institute for Microbiology, Ministry of Defence, Munich, DEU; 3- Cardiff University, Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff, GBR LP 08 A cross-reactive monoclonal antibody raised against recombinant hepatitis E virus genotype 3 capsid antigen B Kubickova1, JA Schenk2, K Marcinkeviciute3, J Reetz4, P Dremsek1, PL Tamosiunas3, R Petraityte-Burneikiene3, JF Drexler5, A Andersson4, D Becher6, MH Groschup1, F Sellrie2, R Johne4, and RG Ulrich1 1- Friedrich-Loeffler-Institut, Greifswald, DEU; 2- Hybrotec GmbH, Potsdam, DEU; 3Vilnius University, Vilnius, Lithuania; 4- Federal Institute for Risk Assessment, Berlin, DEU; 5- Universitätsklinikum Bonn, Bonn, DEU; 6- Micromun GmbH, Greifswald, DEU Medical Biodefense Conference 2016 LP 09 Comparative analysis of the antigenic properties of the tick-borne encephalitis virus strains used for vaccination YS Bukin1, YP Dzhioev2, VI Zlobin2, IV Kozlova3, SE Tkachev4, and D Ruzek5 1- Limnological Institute, SB RAS, Irkutsk, RUS; 2- Irkutsk State Medical University, Irkutsk, RUS; 3- Scientific Center for Problems of Family Health and Human Reproduction, Irkutsk, RUS; 4- Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, RUS; 5- Institute of Parasitology, Biology Centre of the Academy of Sciences, České Budějovice, CZE LP 10 Eavualtion of humoral immunity against smallpox in Brazilian army CBRN troops NV Cruz1, RH Peralta2, and C Damaso3 1- Biology Institute of Brazilian Army, Education and Research Division, Rio de Janeiro, BRA; 2- Fluminense Federal University, School of Medicine, Niterói, BRA; 3- Federal University of Rio de Janeiro, Biophysics Institute, Rio de Janeiro, BRA LP 11 The Regional Differences of the Human Immunological Response to Anthrax Infection N Chitadze1, M Doganay2, E Parlak3, U Kayabas4, M Parlak3, M Sunnetcioglu5, M Karahocagil5, and P Baillie6 1- National Center for Disease Control and Public Health, Virology and Molecular Biology, Tbilisi, GEO; 2- Erciyes University, Kayseri, TUR; 3- Ataturk University, Erzurum, TUR; 4Inonu University, Malatya, TUR; 5- Yuzuncu Yil University, Van, TUR; 6- School of Pharmacy and Pharmaceutical Sciences College of Biomedical and Life Sciences Cardiff University, Cardiff, GBR LP 12 γ-Glytamyl Transpeptidase of Francisella tularensis as drug target for the development of a new class of anti-infectives C Daschkin1, Z Sahavi-Ouriaghi1, MH Antwerpen2, H von Buttlar2, G Popowicz4, M Gerhard1, and H Meyer1 1- Technical University Munich, Institut für medizinische Mikrobiologie, Immunologie und Hygiene, Munich, DEU; 2- Bundeswehr Institute of Microbiology, Munich, DEU; 3Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Institute of Structural Biology, Neuherberg, DEU LP 13 Computer-Aided Design of Novel Nucleoside Analogues as Dengue Virus Inhibitors. CM Cima1, JJ Bugert2, and A Brancale1 1- Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff, GBR; 2Armed Forces Medical Academy, Institute for Microbiology, Munich, DEU LP 14 Targeted Proteomic Analysis of Abrin A Myslivcova Fucikova1, J Klimentova1, M Duracova1, J Dresler2, and Z Krocova1 1- University of Defence, Department of Molecular Pathology and Biology, Hradec Kralove, CZE; 2- Military Health Institute, Praha, CZE LP 15 Analysis of OPCW relevant toxins B Hülseweh, and T Meißner Bundeswehr Research Institute, Biological Laboratory, Munster, DEU 49 Poster Presentations 50 LP Virulence Factors and Pathogenic Mechanisms LP 16 Detection of Clostridium perfringens toxins in complex matrices by mass spectrometry M Ďuráčová1, J Klimentová1, V Sheshko1, A Myslivcová Fučíková1, J Dresler2, and Z Kročová1 1- University of Defense, Department of Molecular Pathology and Biology, Hradec Králové, CZE; 2- Military Health Institute, Prague, CZE LP 17 Ricin vs. Abrin – or how to distinguish twins? AW Weiß, P Vollmar, H von Buttlar, R Wölfel, and MA Hanczaruk Bundeswehr Institute of Microbiology, Department for Bacteriology and Toxinology, Munich, DEU LP18 Sensitive detection of Botulinum Neurotoxin combining affinity enrichment and enzyme activity detection H Buttlar, I Mochner, P Kriebs, and R Woelfel Bundeswehr Institute of Microbiology, Bacteriology and Toxinology, Munich, DEU LP 19 Improvement of Ricin detection in food chain matrices by affinity enrichment H Buttlar, M Hanczaruk, P Kriebs, and R Woelfel Bundeswehr Institute of Microbiology, Bacteriology and Toxinology, Munich, DEU LP 20 Effects on the structure of the proteins ricin and SEB M Kruse1, M Winkler2, S Schirmer2, and B Niederwöhrmeier2 1- Bundeswehr Research Institute for Protective Technologies and NBC Protection, Biological Lab, Munster, DEU; 2- Bundeswehr Research Institute for Protective Technologies and NBC Protection, B-Detection, Munster, DEU LP 21 Novel cell targeting L-ddBCNA antiviral inhibits autophagy in measles virus infected cells. LJ Farleigh1, R Narayan1, D Friese2, E Sayers1, AT Jones3, C McGuigan3, and JJ Bugert2 1- Cardiff University, Medical Microbiology, Cardiff, GBR; 2- Bundeswehr Institute of Microbiology, Munich, DEU; 3- Cardiff University, Pharmacy and Pharmaceutical Sciences, Cardiff, GBR MP Anti-Infective Strategies - Vaccines and Antibiotics MP 01 Efficacy assessment of anthrax vaccines S Charlton1, H Cuthbertson1, K Thomas1, E Hughes1, L Mcinroy1, D Powell1, P Proud1, C Neil1, K Steeds1, M Matheson2, A England2, S Funnell3, I Taylor4, G Hatch4, and B Hallis1 1- Public Health England, Vaccine Research Group (National Infections Service Porton), Salisbury, GBR; 2- Public Health England, Immunoassay Group (National Infections Service Porton), Salisbury, GBR; 3- Public Health England, Biodefense and Preclinical Evaluation Group, Salisbury, GBR; 4- Public Health England, Biological Investigations Group, Salisbury, GBR Medical Biodefense Conference 2016 MP 02 Engeneering of Neutralizing Human Recombinant Antibodies Derived from Immunoglobulin Libraries binding to Orthopox Virus Envelope Proteins. US Diesterbeck1, A Frenzel2, H Ahsendorf3, T Schirrmann2, S Dübel2, and CP Czerny3 1- NIH, NIAID, Laboratory of Viral Diseases, Bethesda, USA; 2- Technische Universität Braunschweig, Institute of Biochemistry, Biotechnology and Bioinformatics, Braunschweig, DEU; 3- Georg-August-University, Department of Animal Sciences, Göttingen, DEU MP 03 Recombination between Modified vaccinia virus Ankara-vectored influenza vaccine and a feline cowpox virus during co-infection and superinfection in Vero cells DD Canova1, TG Oludotun2, AS Okoli1, Ø Nilssen3, U Moens4, M Tryland5, T Bøhn6, T Traavik1, B Entler7, and MI Okeke1 1- GenØk-Centre for Biosafety, Virology, GM Viruses and Vaccines, Tromsø, NOR; 2IMC University of Applied Sciences, Medical and Pharmaceutical Biotechnology, Krems, AUT; 3- UiT The Arctic University of NOR, Clinical Medicine, Tromsø, NOR; 4- UiT The Arctic University of NOR, Medical Biology, Tromsø, NOR; 5- UiT The Arctic University of NOR, Arctic and Marine Biology, Tromsø, NOR; 6- GenØk-Centre for Biosafety, Ecotoxicology, Tromsø, NOR; 7- IMC University of Applied Sciences Krems, Medical and Pharmaceutical Biotechnology, Krems, AUT MP 04 Establishment of Processes for the Development of Monoclonal and Polyclonal Antibodies in the Country of Georgia T Shutkova1, E Nalbandishvili1, V Kakhadze1, T Deal1, B Jenkins2, J Czarnecki2, and S Tsanava1 1- National Center for Disease Control and Public Health, Tbilisi, GEO; 2- Naval Medical Research Center, Frederick, USA MP 05 A complex approach for development of safe vaccines against human orthopoxvirus infections RA Maksyutov, SN Yakubitsky, IV Kolosova, SN Shchelkunov State Research Center of Virology and Biotechnology "VECTOR”, Koltsovo, Novosibirsk region, RUS MP 06 Identification of novel tularemia vaccine candidates V Sheshko, M Schmidt, and J Stulik University of Defence, Faculty of Military Health Sciences, Hradec Kralove, CZE MP 07 Testing of new compounds with potential activity against Mycobacterium tuberculosis O Pavliš1, P Kubíèková1, J Roh2, and V Klimešová2 1- Military Health Institute, Department of Biological Defense, Tìchonín, CZE; 2- Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Hradec Králové, CZE MP 08 Anthrax Toxin Removal by Fusion Protein Immobilised on New Cryogel Materials E Lis1, A Leistner1, M Stier1, A Leistner1, and L Baillie2 1- Polymerics GmbH, Berlin, DEU; 2- Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff, GBR 51 Poster Presentations MP Anti-Infective Strategies - Vaccines and Antibiotics MP 09 The efficient removal of anthrax toxin from human blood using monoclonal antibodies immobilized on a disposable polymeric cryogel G Ingavle1, S Sandeman1, Y Zheng1, S Mikhalovsky1, and L Baillie2 1- University of Brighton, School of Pharmacy and Biomolecular Sciences, Brighton, GBR; 2- Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff, GBR MP 10 An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels B Haagmans1, J van den Brand1, V Raj1, A Volz2, P Wohlsein3, S Smits1, D Schipper1, T Bestebroer1, N Okba1, R Fux2, A Bensaid4, D Foz4, T Kuiken1, W Baumgärtner3, J Segalés4, G Sutter2, and A Osterhaus5 1- Erasmus Medical Center, Department of Viroscience, Rotterdam, NLD; 2- LMU Munich, Institute for Infectious Diseases and Zoonoses, Munich, DEU; 3- University of Veterinary Medicine, Department of Pathology, Hannover, DEU; 4- Campus de la Universitat Autònoma de Barcelona, Centre de Recerca en Sanitat Animal (CReSA), Barcelona, ESP; 5- University of Veterinary Medicine, Center for Infection Medicine and Zoonoses Research (RIZ), Hannover, DEU NP 52 Fostering Biosafety for a Safer World Advanced training session by the German Partnership Program for Excellence in Biological and Health Security NP 01 Brucellosis and Q-Fever Infections in Egypt H El-Adawy, J Klemmer1, F Melzer1, and H Neubauer1 Friedrich Loeffler Institut, Institute of Bacterial Infections and Zoonoses, Jena, DEU NP 02 Glanders and Brucellosis in Ukraine MC Elschner1, F Melzer1, R Koziy2, and H Neubauer1 1- Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Bacterial Infections and Zoonoses, Jena, DEU; 2- State Scientific Control Institute of Biotechnology and Strains of Microorganisms, Kiev, UKR NP 03 Outbreak preparedness in developing countries - Conclusions from a conference, capacity building workshop and infrastructure adaptation in Mbeya, Tanzania G Froeschl1, NE Ntinginya2, A Sangare3, P Lawala3, C Mangu2, G Dobler4, N Heinrich1, B Flach4, A Nsojo3, and T Lennemann1 1- Medical Centre of the University of Munich, Division of Infectious Diseases and Tropical Medicine, Munich, DEU; 2- National Institute of Medical Research, Mbeya Medical Research Center, Mbeya, TZA; 3- Mbeya Zonal Referral Hospital, Mbeya, TZA; 4Bundeswehr, Institute of Microbiology, Munich, DEU NP 04 Tick-borne Encephalitis virus (TBEV) investigation in Georgia T Jashiashvili1, R Sukhiashvili1, S Thumann2, M Strehle2, R Wölfel2, and P Imnadze1 1- National Center for Disease Control and Public Health (NCDC), Richar G. Lugar Center for Public Health Research, Tbilisi, GEO; 2- Bundeswehr Institute of Microbiology, Bacteriology & Toxinology, Munich, DEU Medical Biodefense Conference 2016 NP 05 German-Georgian Collaboration for Global Health Security A Gamkrelidze1, P Imnadze1, and R Wölfel2 1- National Center for Disease Control and Public Health, Tbilisi, GEO; 2- Bundeswehr Institute of Microbiology, Munich, DEU NP 06 Strengthening Biosafety and Biosecurity in Sudan – an unprecedented cooperation IE Andernach1, J Wolf2, N Hanschmann1, W Biederbick2, and R Grunow1 1- Robert Koch Institute, Centre for Biological Threats and Special Pathogens - Highly Pathogenic Microorganisms, Berlin, DEU; 2- Robert Koch Institute, Strengthening Global Biosecurity, Berlin, DEU NP 07 The German Partnership Program Supports Biorisk Management in Kazakhstan S Frey1, Z Shapiyeva2, R Yegemberdiyeva3, A Dmitrovsky3, L Yeralyeva3, N Turebekov4, K Abdiyeva4, J Zinner1, A Zhalmagambetova5, and S Essbauer1 1- Bundeswehr Institute of Microbiology, Virology & Rickettsiology, Munich, DEU; 2- Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring, Parasitology, Almaty, KAZ; 3- Kazakh National Medical University, Almaty, KAZ; 4- Ludwig-Maximillians-Universität, Center for International Health, Munich, DEU; 5- Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ), Almaty, KAZ NP 08 Improving biosafety in ministry of health laboratories in Morocco R Selka1, M Rhajaoui1, and A Maaroufi2 1- National Institut of hygiene, Ministry of Health, Rabat, MAR; 2- Direction of Epidemiology and fight against diseases, Ministry of Health, Rabat, MAR NP 09 Crimean-Congo Hemorrhagic Fever Virus Infections in Sub-Saharan Africa: diagnostic challenges for seroprevalence studies in ruminants M Mertens, MA Sas, I Schuster, and MH Groschup Friedrich-Loeffler-Institut, Institute for Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, DEU NP 10 Brucellosis in Pakistan H El-Adawy1, I Khan2, F Melzer1, and H Neubauer1 1- Friedrich Loeffler Institut, Institute for Bacterial Infections & Zoonoses, Jena, DEU; 2-College of Veterinary and Animal Sciences, Section of Epidemiology and Public Health, Jhang, PAK NP 11 Experience of our Virology Laboratory (Pasteur Institute Casablanca) during Ebola virus outbreak in West Africa J Nourlil1, A Faouzi1, L Anga1, and N El Mdaghri2 1- Institut Pasteur du Maroc, Virology, Casablanca, MAR; 2- Institut Pasteur du Maroc, Casablanca, MAR NP 12 Biosafety/ Biosecurity activities of the German Partnership Program in Morocco: Goals and way forward O Kysil1, JP Böttcher2, R Selka3, J Nourlil4, L Wakrim4, M Abid4, S Abdelouhab4, N Barakate3, L Ouaffak3, N El Mdaghri4, M Rhajaoui3, and R Grunow2 1- Robert Koch-Institut, Strengthening Global Biosecurity, Berlin, DEU; 2Robert Koch-Institut, Centre for Biological Threats and Special Pathogens, Berlin, DEU; 3 Institut National d’Hygiène (INH), Rabat, MAR; 4 - Institut Pasteur du Maroc, Casablanca, MAR 53 Poster Presentations OP 54 Emerging Diversity of Intracellular Agents OP 01 Distribution of Tick-Borne Rickettsioses in Mongolia D Altantogtokh, D Tserennorov, B Bolorchimeg, N Tsogbadrakh, and G Ganbileg National Center for Zoonotic Diseases, Ulaanbaatar, MNG OP 02 Chronic Q fever endocarditis in a patient with recurrent aortic valve prosthesis P Vollmar1, B Thoma1, S Feihl2, U Reischl3, A Hiergeist3, S Bleiziffer4, K Specht5, C Kahlhofer1, MC Walter1, and D Frangoulidis1 1- Bundeswehr Institute of Microbiology, Munich, DEU; 2- Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, DEU; 3- Institute of Medical Microbiology and Hygiene, Universitätsklinikum Regensburg, , Regensburg, DEU; 4- Department of Cardiovascular Surgery, German Heart Center Munich, Munich, DEU; 5- Institute of Pathology, Technische Universität München, Munich, DEU OP 03 Emerging tularemia in the county of Oslo, Norway T Hoel1, S Helland2, and O Scheel2 1- Oslo University Hospital, Ulleval, Department of Infectious Diseases, Oslo, NOR; 2Armed Forces Medical Services, Institute of Microbiology, Oslo, NOR OP 04 The epidemiology of tick-borne rickettsioses in Kazakhstan L Yeraliyeva1, R Yegemberdiyeva1, A Dmitrovskiy1, Z Shapiyeva2, N Turebekov1, and A Dushpanova1 1- Kazakh National Medical University, Almaty, KAZ; 2- Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring, Almaty, KAZ OP 05 Rickettsial biodiversity and emerging health risk in France L Kurzrock1, R Oehme2, P Sebastian1, and U Mackenstedt1 1- Institute of Parasitology, University of Hohenheim, Stuttgart, DEU; 2- State Health Office Baden-Wuerttemberg, Stuttgart, DEU OP 06 Rickettsia diversity in small mammals from South Africa S Essbauer1, M Hofmann1, C Kleinemeier1, and S Matthee2 1- Bundeswehr Institute of Microbiology, Munich, DEU; 2- Stellenbosch University, Department of Conservation Ecology and Entomology, Matieland, ZAF OP 07 The Pangenome and Variome of Coxiella burnetii MC Walter, and D Frangoulidis Bundeswehr Institute of Microbiology, Munich, DEU OP 08 Do lice deserve their lousy reputation? S Cutler1, S Moutailler2, and M Vayssier-Taussat2 1- University of East London, School of Health, Sport and Bioscience, London, GBR; 2ANSES, Paris, FRA Medical Biodefense Conference 2016 PP Tick-Borne Pathogens in Nature PP 01 Detection of Dobrava-Belgrade hantavirus genotype Kurkino in Apodemus agrarius in Germany during 2009-2015 P Strakova, S Schmidt, M Schlegel, S Drewes, and RG Ulrich Friedrich Loeffler Institut, Institut für neue und neuartige Tierseuchenerreger , Greifswald, DEU PP 02 Lyme Borreliosis in Europe: Trend analysis from 1999 through 2014 C Klier1, S Oconnell2, C Kleinemeier3, and R Smith4 1- Munich, DEU; 2- formerly Health Protection Agency, Southhampton, GBR; 3- LMU München, Department for Bacteriology, Oberschleißheim, DEU; 4- Public Health UK, Cardiff, GBR PP 03 First detection of Ixodes inopinatus north of the Alpian Mountains L Chitimia-Dobler1, M Bestehorn1, and S Nava2, G. Dobler1 1- Bundeswehr Institute of Microbiology, Dept of Virology and Rickettsiology, Munich, DEU; 2- INTA, Dept of Parasitology, Rafaela, ARG PP 04 First detection of Hyalomma rufipes in Germany L Chitimia-Dobler, M Bestehorn, G Dobler, and S Wölfel Bundeswehr Institute of Microbiology, Virology & Rickettsiology, Munich, DEU PP 05 First molecular characterization of a complete E gene of a TBE virus strain from Bornholm, Denmark NS Andersen1, R Riess2, L Chitimia-Dobler2, S Skarphédinsson3, PM Jensen4, S Wölfel2, G Dobler2, and M Bestehorn2 1- Odense University Hospital and Clinical Institute, University of Southern Denmark, Clinical Center of Emerging and Vectorborne Infections and Research Unit of Clinical Microbiology , Odense, DNK; 2- Bundeswehr Institute of Microbiology, partner of German Center of Infection Research (DZIF), Munich, DEU; 3- Odense University Hospital, Clinical Center of Emerging and Vectorborne Infections, Odense, DNK; 4- University of Copenhagen, Department of Plant- and Environmental Sciences, Copenhagen, DNK PP 06 Tick-borne encephalitis in Germany– Actual Situation and Trends G Dobler Bundeswehr Institute of Microbiology, Dept of Virology and Rickettsiology, Munich, DEU PP 07 Clinical and epidemiological characteristics of tick-borne encephalitis in Kazakhstan R Yegemberdiyeva1, A Dmitrovskiy1, Z Shapiyeva2, L Yeraliyeva1, N Turebekov1, K Abdiyeva1, and A Shin1 1- Kazakh National Medical University, Almaty, KAZ; 2- Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring, Almaty, KAZ 55 Poster Presentations 56 PP Tick-Borne Pathogens in Nature PP 08 The unique combined natural foci of tick-borne infections in the Irkutsk region, Russia I Kozlova1, O Lisak1, E Doroshchenko1, O Suntsova1, J Savinova1, M Verkhozina2, Y Dzhioev1, V Rar3, S Tkachev3, T Demina4, A Paramonov1, and V Zlobin5 1- Scientific Centre of Family Health and Human Reproduction Problems, Laboratory of Molecular Epidemiology and Genetic Diagnostics, Irkutsk, RUS; 2- Centre for Hygiene and Epidemiology in Irkutsk region, Department of Virology Research and PCR Laboratory, Irkutsk, RUS; 3- Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Novosibirsk, RUS; 4- Irkutsk State Academy of Agriculture, Faculty of Veterinary Medicine and Biotechnology, Irkutsk, RUS; 5- Institute of Biomedical Technology, Irkutsk State Medical University of Russian Ministry of Heath, Laboratory of Molecular Virology and Biotechnology, Irkutsk, RUS PP 09 Some Results Spatial Analyze of Distribution I. persulcatus Tick in Mongolia J Battsetseg, N Uranshagai, and D Tserennorov National center for zoonotic diseases, Ulaanbaatar, MNG PP 10 Tick borne-pathogens in ticks infesting humans from Sibiu County, Romania M Andersson1, G Marga2, L Pricop3, P Tamba3, T Banu4, G Dobler5,6, and L ChitimiaDobler5,6 1- Lund University, Molecular Ecology and Evolution Lab, Lund, SWE; 2- Public Health Direction, Epidemiological Surveillance and Disease Control Department, Sibiu, ROU; 3Institute for Diagnosis and Animal Health, Molecular Biology, Bucharest, ROU; 4- Institute for Diagnosis and Animal Health, Epidemiology, Bucharest, ROU; 5- Bundeswehr Institute of Microbiology, Virology and Rickettiology, Munich, DEU; 6- German Center of Infection Research (DZIF), Munich PP 11 The Situation on Tick-borne Dieseases in Kazakhstan Z Shapiyeva1, R Yegemberdiyeva2, and L Yeraliyeva3 1- SPC SEEM, Epidemiology and Parasitology, Almaty, KAZ; 2- KazNMU, Infectious Diseases, Almaty, KAZ; 3- KazNMU, Institute of Applied Medicine, Almaty, KAZ PP 12 Who are you and where are you from? Comparison of Methods for Identification and Trace-Backing of Vectors A Nikolic1, L Chitima-Dobler2, G Dobler2, and MH Antwerpen1 1- Bundeswehr Institute of Microbiology, Microbial Genomics and Bioforensics, Munich, DEU; 2- Bundeswehr Institute of Microbiology, Virology and Rickettsiology, Munich, DEU PP 13 Molecular survey of tick-borne pathogens in wild boars from Central Italy M Di Domenico1, C Cammà1, V Curini1, F Dall Acqua1, D Di Sabatino1, and I Pascucci1 Istituto Zooprofilattico Sperimentale, Teramo, ITA PP 14 Tick screening at military training sites in Austria M Weiler1, G Duscher2, P Hufnagl3, and J Walochnik4 1- CBRN-Defense School, Korneuburg, AUT; 2- University of Veterinary Medicine, Medical Biodefense Conference 2016 Institute of Parasitology, Vienna, AUT; 3- AUTn Agency for Health and Food Safet , Vienna, AUT; 4- Medical University of Vienna, Institute of Specific Prophylaxis und Tropical Medicine, Vienna, AUT PP 15 Establishing of a MALDI-TOF database for identifying African ticks MH Antwerpen, M Weiß, B Flach, K Baumann, G Dobler, and L Chitima-Dobler Bundeswehr Institute of Microbiology, Munich, DEU 57 General Information Conference Venue and Date The Medical Biodefense Conference 2016 will take place from 26th to 29th April 2016 at the Bundeswehr Medical Academy in Munich: Ernst von Bergmann Barracks Neuherbergstrasse 11 80937 Munich Germany The conference will be held on military premises (Ernst von Bergmann Barracks). Access to the barracks is possible only through the main gate and upon presentation of a valid passport or military ID card. Please make sure that the number entered in the registration form exactly corresponds to the number shown on your passport/ID. If your name is not on the list kept by the guard personnel, you may encounter problems entering the premises. Conference Office / Registration Desk The conference office is located next to the Audimax lecture hall, Entry B, Room 13. Opening hours: 26 April 2016 27 April 2016 28 April 2016 29 April 2016 14:00 — 19:00 08:00 — 18:30 08:00 — 18:30 08:00 — 12:00 Following registration at the conference office, you are requested to wear your name tag inside the barracks at all times. Conference Fee The mandatory conference fee of 110€ is an overhead fee covering all extras such as lunch buffet, beverages served during coffee breaks, abstract book, congress bag, etc. Participation in the Conference Dinner with Bavarian music and hospitality at the Eventstadel, Moosach (Social Events) is optional. The Conference Dinner must be booked separately and will be charged at 45€. CME Points The Conference is accredited by the Bavarian Medical Association. To earn CME credits, participants are asked to register daily in the lists of the Bavarian Medical Association displayed at the registration office. Please indicate your central CME reference number. 58 Medical Biodefense Conference 2016 Registration and Support Deutsche Gesellschaft für Wehrmedizin und Wehrpharmazie GmbH Phone: +49 (0)228 63 24 20 e-mail: [email protected] For further details on registration options, please see the conference website http://www.biodefense2016.org Please note that there is no on-site registration option. Industrial Exhibition During the conference an industrial exhibition will be held by the German Society for Military Medicine and Pharmacy (GSMMP/DGWMP) in the foyer of the Audimax lecture hall. For inquiries: General Secretary of GSMMP/DGWMP Neckarstraße 2a, 53175 Bonn Phone: +49 (0)228 63 24 20 Fax: +49 (0)228 698 53 3 e-mail: [email protected] Exhibitors and Sponsors Sponsors: Exhibitors: Emergent Biosolutions Abaxis Accelerate Diagnostics S. L. Berner International Corp. AID Autoimmun Diagnostika GmbH altona Diagnostics GmbH analyticon instruments GmbH Bruker Daltonik GmbH CTL Europe GmbH Euroimmun AG GlaxoSmithKline GmbH & Co. KG GS GLOVEBOX Systemtechnik GmbH Hermes Arzneimittel GmbH miprolab Mikrobiologische Diagnostik GmbH New England BioLabs GmbH Oxford Nanopore Technologies Ltd Pfizer Pharma GmbH Schülke & Mayr GmbH STERIS Deutschland GmbH ThermoFisher Scientific BRAHMS GmbH 59 General Information Abstract Numbers Abstract numbers are composed of a first letter (A-P), indicating the session to which the presentation has been assigned, a second letter, where O indicates an oral presentation and P indicates a poster presentation, and a serial number. Abstracts are sorted according to their serial numbers in the abstract book. Advice for Speakers Please prepare your presentation as a PowerPoint for Windows® file. Check the Corrigenda and the "Program Changes Board" to find out if there are any changes to the program that might relate to your presentation. Make sure to bring your presentation to the media room at least 30 minutes before your session starts. Files for early morning presentations should ideally be handed in the day before. If possible, arrive at your presentation room prior to the start of the session and introduce yourself to the chair. Keep strictly to the scheduled presentation time, which includes the time for discussion. The chairpersons are advised to start the sessions in time and to terminate the lectures on schedule to avoid any overrun. Advice for Poster Presentations Posters should be prepared in English. The format should not exceed DIN A0 (84.1 cm width x 118.9 cm height; portrait format), and the posters should not be laminated. Mounting materials will be provided. Your poster should be presented on the assigned poster board during the whole conference. Additionally, there will be a special poster session (Thursday, 28th April 2016, 13:30-15:30) during which one of the authors should be personally present at the poster. Poster presenters are encouraged to distribute one-page handouts. Poster Awards The German Society for Military Medicine and Pharmacy will honor three posters with a poster award (kindly supported by altona Diagnostics GmbH), which will be presented to the award winners during the poster award ceremony on 28th April 2016 at 16:00h. 1st prize: 500 EUR 2nd prize: 300 EUR 3rd prize: 200 EUR Conference Language The official conference language is English. 60 Medical Biodefense Conference 2016 Meals and beverages Lunch snack buffet (Wednesday and Thursday only) and beverages served during coffee breaks (coffee, tea, soft drinks) are covered by the conference fee. Meals are also available for purchase at the Officers Mess (payment in cash only). Casual dress is acceptable for all meals. No shorts or sandals as per dress policy. Participants may also use the Dining Hall (Bldg. 8) as well (payment in cash or with prepaid card issued by Verpflegungsmanagement der Bundeswehr). Opening hours Officers´ Mess: Breakfast Lunch Dinner 07:00 - 11:00 11:00 - 13:00 16:00 - 22:00 Opening hours Dining Hall (Bldg. 8): Breakfast Lunch Dinner 05:45 - 07:30 11:00 - 12:30 16:00 - 17:30 Social Events Icebreaker The German Society for Military Medicine and Pharmacy invites the participants to a Welcoming Reception, which will take place on Tuesday, 26h April 2016, 18:00-21:30 in the Sergeants´ Mess on the premises of the Bundeswehr Medical Academy. Participation is free. Conference Dinner The German Society for Military Medicine and Pharmacy invites the conference attendees to a social event at the Eventstadel, Moosach / Wasserburg (Wednesday, 27th April 2016, 19:00 - 22:30). Bus transportation to this location will be available. Participation in the Conference Dinner will be 45 EUR for a three-course menu (two beverages included). If you have not yet enrolled for the Dinner in advance, please ask for residual tickets on-site at the registration desk. Phone numbers Conference office (during opening hours): +49 (0)89 992692 4513 Officer on duty (room key pickup after closing of the conference office): +49 (0)89 992692 4600 Bundeswehr Institute of Microbiology: +49 (0)89 992692 3981 In case of emergency call: Medical center of the Academy: +49 (0)89 992692 3333 or Civilian Ambulance: 112 61 General Information Travel and Transportation Free shuttle bus service: There will be a free shuttle service between „Harthof“ underground station (U2) and the conference venue for your arrival on 26th April from 14:00 to 18:30 hrs and for late arrivals on 27th April from 8:00 to 9:00 hrs as well as for your departure on 28th April from 16:00 hrs to 19:00 hrs and on 29th April from 07:00 hrs to 14:00 hrs. The venue (Ernst von Bergmann Barracks) can be reached as follows : By airplane: The nearest airport is Franz-Joseph-Strauss Airport in Munich (MUC). To reach the center of Munich you can use the Lufthansa Airport Shuttle Bus (operating from 06:25 to 22:25 hrs every 20 min; approx. 11 EUR for a single ticket) or the suburban train (S-Bahn S8, approx. 12 EUR for a single ticket) to the main station. You will also find car rental agencies or taxis at the airport (one-way taxi fare approx. 50 EUR). To directly reach the conference venue, use suburban train S1 and change to underground train U2 at Feldmoching. Get off at the stop „Harthof“. From there you can take the free shuttle bus or city bus line 170 to „Kieferngarten“ or 141 to „Scheidplatz“ and get off at the stop „Rose-Pichler-Weg“, which is right next to the main gate. Further information: http://www.munich-airport.de/en/consumer/index.jsp By train: From the main station, take underground train U2 to Feldmoching and get off at the stop „Harthof“. There, take the free shuttle bus or the city bus lines 141 or 170 to „Münchner Freiheit“ or „Kieferngarten“. Get off at the stop „Rose-Pichler-Weg“ and you will find yourself right next to the main gate. Further information: http://www.bahn.de/i/view/USA/en/index.shtml Use Google Route Planner to help guide you to the conference venue: https://maps.google.com/maps?output=classic&daddr=%4048.21061124615,11.581563949585 By car: Highway A8 Stuttgart-Munich: At Eschenried intersection change to highway A99 to Salzburg. Take the exit Neuherberg, then drive in the direction of Munich. After passing the city boundaries, turn right into Neuherbergstrasse at the first traffic lights; after 400 m you will find the main gate on the left hand side Highway A9 Nuremberg-Munich: At Neufahrn intersection change to highway A92 to Stuttgart, then at Feldmoching junction to highway A99 to Salzburg. Take the exit Neuherberg, then drive in the direction of Munich. After passing the city boundaries, turn right into Neuherbergstrasse at the first traffic lights; after 400 m you will find the main gate on the left hand side. 62 Medical Biodefense Conference 2016 Highway A8 Salzburg-Munich: At the intersection München Brunnthal change to highway A99 to Nuremberg/Stuttgart, then stay on the A99. Take the exit Neuherberg, then drive in the direction of Munich. After passing the city boundaries, turn right into Neuherbergstrasse at the first traffic lights; after 400 m you will find the main gate on the left hand side. When arriving by car, please note that there are parking restrictions on the barracks’ premises. Please do not park on reserved parking spaces. Hotel shuttle bus (provided by the German Society for Military Medicine and Pharmacy) Guests staying at the recommended conference hotels may use the complimentary hotel shuttle bus on 27 to 29 April for commuting to the conference venue in the morning and back in the evening. You will be informed about departure times of the buses when checking in at the conference office. Guests staying at other hotels should use public transport. 63 Map of Ernst von Bergmann Barracks 64 Medical Biodefense Conference 2016 _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ 65 _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________ _______________________________________________________________________