selenium 01% brochure 2015

BIOAVAILABILITY, ABSORBABILITY
AND STABILITY COMBINED!
POWDER
SELENIUM prevents problems in farrowing, such as high piglet mortality, lethargic
and weak piglets, as well as mulberry heart disease. It enhances muscle tone and strength
of sows, preventing dystocia and related stillbirths. It is a primary component of
Glutathione peroxidase (GPX), that functions to protect the cell membrane from
oxidation preventing carcass paleness, drip loss and increased shelf-life of eggs in poultry
SELENIUM CHELATE* is a 4th generation chelate**, produced in a three stage
chelation process utilizing final form amino acids as ligands, assuring complete
and stability
SELENIUM CHELATE* is non-buffering to gastric pH, helping maintain optimum
High Bioavailability Selenium Supplement
SELENIUM CHELATE
CURRENT NUTRITION
NUTREX
TECHNOLOGY EXPONENTS
XPONENTS
chelation of selenium ions, resulting to unequalled bioavailability, absorbability
acidity for protein digestion and immune enhancement
SELENIUM CHELATE* is non-precipitative in intestinal pH—does not form gut
harmful “magma”
SELENIUM CHELATE* is non-reactive to vitamins and other vital nutrients in the
gut—resulting to unimpaired vitamin bioavailability
SELENIUM CHELATE* is independently absorbed and is not antagonized by other
minerals and substances (e.g. phytic acid)
SELENIUM CHELATE* is the superior, high bioavailability selenium supplement for
predictable and cost effective growth performance enhancement
* As compared with inorganic selenium
**Should be differentiated with “dry blends/complexes”, which are mere physical attachment of the amino acids
with the metal (tends to separate into its component parts in acidic pH)
CONTENTS
Selenium amino acid chelate 1M µg* (bioavailable Selenium)
Carrier calcium carbonate q.s. ad
1 kg
*Equivalent to 1,000 ppm
RECOMMENDED USE AND DOSAGE
Use at 80-300g/ton of feed to achieve 0.08-0.3 ppm active bioavailable Selenium
PACKAGING
25 kg box
A Performance Enhancing Nutritional Product of:
AGRIaccess
4714 175th ST SE Bothell WA 98012 USA
www.agriaccess.com
METABOLIC ROLE OF SELENIUM
1.
2.
3.
recently recognized as one of the
more essential micronutrient for
humans and animals - multi-organ,
protective and regulatory role
primary metabolic role - major
antioxidant - as a vital component
of GLUTATHIONE PEROXIDASE (GPX1)
secondary roles - functional part of
various enzymes (GPX2, GPX3,
GPX4, iodothyronine deiodonases,
thioredoxin reductase selenoprotein P & W, and functional mitochondrial proteins )

acid and glycine
major antioxidant enzyme in humans and animals
(Rotuck et.al. 1973, X.G. Lei 1999)
GPX1
 cellular location, present in most
body cells
 composed of selenium and three
amino acids — cysteine, glutamic
THE SELENIUM METHIONINE
ISSUE
Taking the Animal Perspective
Selenomethionine is the storage form
of selenium in PLANTS. The
functional, and to a certain extent
storage, and plasma transport form in
ANIMALS is selenocysteine (Hill
et.al.1991)
Methionine is convertible to cysteine.
But as methionine is a limiting
essential amino acid, and cysteine is a
common, non-essential amino acid, in
the animal there practically exists a
RARE
NEED
TO
CONVERT
METHIONINE TO CYSTEINE.
DIAGRAM OF SELENIUM METABOLISM IN MAMMALS
and in the tRNA Se joins the amino
acid Serine to form selenoprotein
THUS - if selenomethionine is absorbed - chances are it will NOT be
converted to selenocysteine - selenium
in selenomethionine will either be
extracted and combined with required
amino acids, OR remain as-is, used as
methionine or excreted.
- actual bioavailability of selenomethionine is much lower than the GPX
composite amino acid chelates
(Sunde 1999)
Shows selemethionine has to pass thru
the same breakdown and recombination
process, then the extracted Se joins the
intracellular inorganic mineral pool,
COMPARATIVE BIOAVAILABILITY
OF DIFFERENT SELENIUM FORMS
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)
PROFILE Selenium Amino Acid Chelate 1%
_________________________________
Form
Bioavailability
————————————————–
Se amino acid
>90%
Se methionine yeast
<45%
Se methionine complex
<25%
Na selenite (inorganic)
<0.05%
————————————————–
(HPLC
is the
preferred screening or assay tool
of biotechs for
organic
molecules/materials;
(Methionine
included in solution to provide
perspective)