2014 ADHB Research Report - Auckland District Health Board

Transcription

Annual Research Report 2014
Auckland District Health Board
Welcome to the Auckland DHB
Annual Research Report for 2014.
Having an excellent programme of research distinguishes great hospitals. Auckland
District Health Board – ADHB - is the largest tertiary care centre and the largest clinical
research facility in New Zealand. Our research portfolio comprises over 1100 projects
and our doctors, nurses, allied health professionals and scientists engage in research
that attracts funding, participation and peer esteem both from New Zealand and
internationally.
ADHB’s hospitals are teaching hospitals and ADHB partners with the University of
Auckland in an Academic Health Alliance. Its goals, to deliver research-informed
healthcare alongside clinical teaching and training, will fast-track translation of research
findings from “bench to bedside”, and onwards to communities and families.
ADHB provides a first-class setting for research across the health spectrum. We serve a
diverse population (with rapidly expanding migrant population) of over 400,000 as the
local provider, and over 1.3 million as regional provider of specialist health services. Acute
services are provided together under one roof so researchers can access participants
under the care of skilled multidisciplinary teams of specialists with specialist equipment.
ADHB’s accredited laboratory facility, LabPlus, provides a range of on-site laboratory
services for clinical research, including diagnostic and genetic analysis, storage, disposal
and shipping to central laboratories worldwide.
Research at ADHB pays for itself – over 80 staff and a multitude of medical and laboratory
procedures for research are paid for from external sponsorship, both commercial and
charitable. The A+ Trust provides robust management of research monies, and interest
earned on Trust funds is fed back into the organisation as a contestable research grants
programme worth a half million dollars annually.
ADHB is committed to preserving our status as a centre of clinical excellence by fostering
our involvement in research activity, critiquing health care approaches and investigating
new initiatives. We celebrate our contribution to health through research with our
annual ADHB Research Excellence Award, Young Investigator Award, Best Research
Posters and now the best summer students reports. Within the diversity, integral to all
ADHB research is a desire by our committed staff to build a strong evidence base for our
clinical, community and policy work, and ultimately, the good health and well-being of
our patients.
Welcome to the ADHB Annual Research Report for 2014.
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Contents
Welcome to the Auckland DHB Annual Research Report for 2014
1
Introduction from the CMO 4
A word from the ADHB Research Office
5
Collaborations
8
Auckland Academic Health Alliance
9
SHIVERS
12
ADHB Research Excellence Awards
14
Current Research
17
Funding for Research
52
Promoting Research
63
Honours and Awards
66
Publications
70
Directory
109
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Introduction from the CMO
I am delighted to start this foreword by celebrating the fact that ADHB has over
1000 research projects registered with our research office. That is a sizeable
portfolio of research activity and represents every type of research; quantitative
and qualitative, small audit to multicentre randomised control trial, clinical and
bench methods, student to experienced researcher led. This research activity
translates into many publications and presentations to scientific and lay meetings,
and some of those will be highlighted in this report.
In order to support, and provide assurance, to our research community we have in
this last year appointed a Clinical Lead Research, Dr Colin McArthur and established
a Research Governance Committee comprising membership from the University
of Auckland, the A+ Trust and the ADHB. This committee provides oversight for
the activities of the Research Office and ensures that our research complies with
necessary regulations, and that any issues relating to research are resolved. It also has
an important strategic role and together with the University of Auckland, with whom
we have a formal Academic Health Alliance, we hope to grow research even further.
This year, for the first time, we have a new research funding opportunity courtesy of
the University and the A+ Trust. The new Auckland Academic Alliance research grants
aim to foster new and existing collaborations between our respective organisations,
and from this opportunity we hope to see the emergence of more substantial grant
applications to bodies such as the HRC.
All of this activity does not happen without a lot of work behind the scenes and I would
like to thank Mary-Anne Woodnorth and her team in the Research Office, Drs Colin
McArthur and Kim Brackley who have ably chaired the Research Review Committee and
of course all the members who have given up their time to read research applications. I
also acknowledge the A+ Trust which hosts our research revenues and allows us to use
the interest on research surpluses to fund new peer reviewed research activities, the
A+ Trust grants. The Trust also sponsors summer students and this year the quality of
research outputs was high with fierce competition for the Summer Student research
prizes. Congratulations to Lydia Hingston supervised by Drs Ken Whyte and Kevin
Ellyett. Thanks also to Prof Andrew Shelling and the University for hosting the awards
ceremony.
For new and aspiring researchers, I encourage you to continue to question, puzzle and
formulate hypotheses - and then set about trying to answer the question, solve the
puzzle or prove your hypothesis. If you want advice, come to the research office and
we will try and help you get started. For those who are successful researchers already,
congratulations on your publications and other achievements.
Margaret Wilsher
Chief Medical Officer and Head of Research
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A Word from the ADHB Research Office
This document is a comprehensive report of the research activities that commenced at Auckland District Health Board in the years
2012 to 2014. During this period 904 new study protocols were approved and initiated. A total of 447 individuals, the majority
ADHB staff members, took the lead role as site principal investigator for these new studies. Countless more were co-investigators,
research nurses and co-ordinators, supervisors, mentors, clinical advisors or helpful hands. Considering the size and energy of
the ADHB workforce participating in research it isn’t surprising that research activity spans the organisation and extends beyond
it, as evidenced by the breadth and quality of our external collaborations both nationally and internationally. In fact, ADHB has
been experiencing something of a research boom, with each successive year in this reporting period having the highest number
of new projects to commence on record. The new record set in 2014 is 327, which represents a 100% increase in volume since
ADHB starting producing research reports in 2006 and leads me to ponder about what might be driving such a surge. Certainly a
number of changes and new initiatives have been advantageous for health and clinical research in the last three years and are worth
mentioning.
New ADHB studies annually
350
300
250
200
150
100
2006
2007
2008
2009
2010
2011
2012
2013
2014
Firstly the reform of the Ministry of Health’s Health and Disability Ethics Committees (HDECs) in 2012 has been a significant driver
to reduce research approval cycle times. Prior to July 2012 researchers were tied to their regional HDEC and the distribution of
partcipating study sites was restricted to the HDEC’s catchment area. Large multi-centre studies were served by a lone, inefficient,
multi-regional HDEC in Wellington. Application was by paper copy in duplicate with ink signatures. The new operating standard
introduced in 2012 saw the number of committees reduced from eight to four, but all multi-regional. Applications are now
submitted via a web-based electronic system and applicants have the option of submitting to their local HDEC or to fast track to
the next available HDEC meeting. Once submitted, applications are guaranteed a decision within acceptable timeframes. Though
complicated and sometimes clunky, the e-submission system was quickly mastered by ADHB research staff. Very low risk studies no
longer require HDEC review and this has pushed ascertainment of minimal risk on to the research organisations themselves. Our
research office has been ably supported by our Research Review Committee to develop good decision rules about supporting low
risk studies and so such studies are now having a far more rapid approval process.
Two crucial new research appointments were made at ADHB in 2013 and 2014. In 2013 Dr Helen Wihongi (Ngati Porou and
Ngapuhi) became the first Māori advisor for research for two DHBs – Auckland and Waitemata. Being co-located in the ADHB
research office two days a week has meant Dr Helen has been able to provide a pre-emptive cultural and Tikanga Māori advisory
service for researchers developing their research plans. After a tough 2012 during which He Kamaka Oranga ADHB Māori Health
team transitioned into He Kamaka Waiora, the ADHB-Waitemata Māori Health collaboration, ADHB was suffering from a shortage
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of Māori research review. A quality improvement “Greenbelt” project run in parallel by our Research Office team and volunteers
from various research groups and attempting to address our then lengthy research approval cycle time made the timely discovery
that rework and faulty loops in our process were exacerbating the delays in getting approval. Arriving in her role to discover a large
number of projects needing review and research staff desparate to obtain approvals to commence, Helen had to quickly acquire an
understanding of the value offering of her role and deal with the backlog. With the learnings from our Greenbelt project we were
able to eliminate the duplications and unnecessary work in our processes and prioritise review for those projects that needed it
soonest. With the support of Naida Glavish and the Māori Research Committee Helen devised and implemented rational standards
for Māori responsiveness relevant to the range of research that is carried out in our organisation.
The other accomplishments of Dr Helen in the first years in her new role are really to be admired – she has been the leader of an
initiative to standardise Māori research review for DHBs nationally which has resulted in the creation of a document “A Framework
for Māori Review of Research in District Health Boards” which will soon be implemented. We acknowledge the financial support of
the A+ Trust and the dedicated work of student researcher Shirley Simmonds, sponsor Naida Glavish, and co-supervisor Dr Tristram
Ingham (Capital and Coast DHB) in the creation of this work. Naida Glavish and Helen have been successful in winning seed funding
for research on the health benefits of karanga (powerful, ceremonial call of welcome by wāhine Māori) from the Health Research
Council of New Zealand. Helen is also a leading light of the growing local community of those interested in establishing national best
practice for tissue bio-banking in health research, with particular emphasis on indigenous ethics and bio-banking. I have no doubt
Helen will continue to act as stimulus and support for Māori-centred research to happen at ADHB and that through the knowledge
gained by investigation health inequalities for Māori will improve.
Intensive care specialist Dr Colin McArthur, busy researcher, chair of the Australian and New Zealand Intensive Care Society Clinical
Trials Group, and long time Research Review Committee member, was appointed as ADHB’s Clinical Advisor for research in 2014
in a 0.2 FTE role funded by the ADHB Charitable Trust (A+ Trust). ADHB was relatively late compared with other research DHBs to
appoint a clinical advisor but the appointment had become a matter of some necessity by 2014 with the research boom in full swing
and RRC’s core of volunteers stretched to unreasonable lengths to maintain good governance over research. Colin, stepping into
the new role took over the leadership of RRC, allowing our steadfast chair Kim Brackley to finally stand down (as chair, not from the
committee). It was immediately clear that having Colin meant having the option to supplement the traditional two stream approval
pathway with a middle road that dealt with studies that were more than minimal risk but not high risk. Redirecting applications
from RRC agendas means RRC are not so overburdened, the time consuming post meeting feedback transactions are obviated and
fewer studies miss out on timely review due to full agendas. And this has not had to be achieved at the cost of clinical risk. Colin
has also been instrumental in establishing the ADHB Research Governance Committee (RGC) which has taken over responsibility
for research strategic direction, probity and safety as workload prevented RRC from exercising these roles. RGC has dealt with an
amazing range of issues and questions in its young life, many emerging from our strategic alliance (Auckland Academic Health
Alliance) with the University of Auckland, and others reflecting the complexity of our ethical and collaborative environments. Colin,
being more often than not the one delegated to action the RGC’s queries and decisions, by dint of his senior position and his
ringfenced research time has been effective in bringing a number of matters to resolution in a timeframe that would have been
impossible prior to his appointment.
I think Colin’s establishment as clinical advisor for research and Helen’s as Māori advisor for research are marks of ADHB’s maturity
as a research organisation. I feel very fortunate to have such able partners and wonderful people to bounce ideas off.
The emphasis placed in recent years by HRC on funding research at the coalface of the health system has allowed DHB researchers
to be competitive against the the more academic researchers of the major universities. Both Colin McArthur and Stewart Dalziel
(Children’s Emergency Department) have obtained substantial funding via the HRC’s Research for NZ Health Delivery funding
stream. Bill Abbott (NZ Liver Transplant Unit) holds an HRC Research Partnerships for Health Delivery grant with his University of
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Auckland and Hepatitis Foundation partners. ADHB researchers have won three of
only six prestigious HRC Clinical Practitioner
Fellowships (Stuart Dalziel, Peter Bergin –
Neurology, and Ralph Stewart - Cardiology).
Helen, Colin and I recently took advantage
of an invitation from the Ministry of
Health to join a discussion group on the
strategic refresh of the HRC and provided
our opinions about how the HRC could
continue to support NZ’s health sector by
investing in top quality research in DHBs.
We look forward to finding out about how
the refreshed HRC can continue to create
an environment favourable to the research
you do. We also look forward to our future
with the University of Auckland as a joined
up research organisation and how we can
leverage the University’s scientific and
technical expertise to add translational
power to joint funding applications.
1073
904
1032
176
$22.6 million
With this report we intend to showcase a range of outputs and
achievements of ADHB staff and their research partners over the last three
years. We count ADHB’s credentials as a research organisation in volumes,
such as new projects approved, number of research publications and value
of grants obtained. What we are not able to show you with this report
particularly well, and what we hope to be able to improve on in coming
years, are the stories about how research has changed DHB practice,
clinically, socially or organisationally, for the better. We are starting to be
able to find out more about the real impact of research through the ADHB
Research Excellence Award, but can do better. If your research project has
created new knowledge that has enabled you to improve your service to
our patients and community please tell us about it!
I acknowledge everyone in our organisation that has supported me,
educated me, cooperated with me, argued, struggled and fought with
me, and ultimately enabled me and my team to provide your research
with the ADHB seal of approval. Congratulations – I hope you enjoy this
report.
Mary-Anne Woodnorth
Manager, Research Office
Number of active research projects in 2014
New projects commencing in 2012-2014
Published research articles 2012-2014
Successful research grant applications involving ADHB 2012-2014
Value of research grants involving ADHB 2012-2014
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Collaborations
The Auckland Academic Health Alliance
The Auckland DHB, in its many incarnations, has been in Grafton long before the
medical school was established alongside it almost 50 years ago. Since then close
clinical and research connections, forged by motivated individuals who saw the
value in working together, have always been maintained.
The foundations of the Auckland Academic Health Alliance – on a campus spanning both sides of Grafton Road, which we see evolving into an academic health
campus, are testimony to the country’s highest, internationally ranked, university
with a medical school ranked 43rd in the world and the country’s largest public
hospital and clinical research facility.
Both institutions have observed 21st century best practice abroad and have recognised
a domestic need to make health sector returns that are greater than their collective
parts.
The Alliance model is focused on a virtuous cycle closely linking patients, research,
teaching and education. This cycle sees patients involved in research, knowledge
reaching patients faster and quicker pathways to commercialisation for research
pioneered and developed by hospital and university researchers and clinicians.
As two of the country’s largest institutions and certainly the two largest employers in
our biggest city we have a single goal.
This is to develop New Zealand’s version of a world-recognised leading tertiary and
medical institution. These have been formed in the United Kingdom, Europe and the
United States.
They are internationally recognised, they are best practice, and they are the drivers of
innovation and research for patients. Patient needs and health outcomes are met by
the Centre.
They are a hub for pioneering clinicians, hospital and university researchers. Put
another way, they are a magnet for people working in the health sector.
So why does New Zealand need an Academic Health Alliance and why should it be in
Auckland? There is an array of reasons.
We have world-recognised health researchers and clinicians here now who have
collaborated. They have lit the pathway and achieved success without support. We
see the Alliance as a multiplier – it will foster more collaborations –and more successes.
Those collaborations and the nurture of the intersection at which research and clinical
practice meet will draw health workers and it will keep them here.
We have health issues specific to New Zealand that need New Zealand research and
solutions. In Auckland we have the greatest density of population – patients are central
to Alliance research.
And we are in an age of increasing health sector costs, an ageing population and an acute
awareness of the efficiencies and gains that can be achieved through collaboration.
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The Auckland Academic Health Alliance
was officially launched by the Minister of
Health the Hon Tony Ryall on Friday
29 November 2013.
The Auckland Academic Health Alliance is an exciting
development. Its deliverables will be even more exciting.
One of the first significant initiatives of the AAHA is the
establishment of a co- funded (A+ Trust and Faculty of Medical
and Health Sciences) research fund designed to support joint
research projects. This is a visible indication of the importance
that the University places on the role of AAHA in its future
plans, and vice versa. It also provides a greater opportunity
to develop collaborative translational research opportunities
that should improve success in competitive research
grants, such as the Health Research Council project and
programme grants.
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Newsflash – Auckland Academic Health Alliance hosts
2014 Summer Studentship Prize presentation
Student researchers work at Auckland DHB during the summer months each year.
These studentship projects are well regarded as being one of the best ways to
utilise local talent to find out things Auckland DHB is interested in knowing, and
for a very small investment. The A+ Trust supports Auckland DHB staff to devise
projects which will answer important clinical question by funding stipends for student workers. Thirteen of these projects have been funded during 2012 to 2014.
The scheme runs under the auspices of the AAHA, with the Faculty of Medical and
Health Sciences administering the grants. The end of project reports prepared by
the 2014 students were recently assessed for scientific quality by an expert panel.
The winner and runner up of the 2014 A+ Trust Summer Studentship prize for best
students’ reports were Lydia Hingston (winner) and Jade Lau Young (runner up).
The prizes to Lydia and Jade were announced by Chief Medical Office Dr Margaret
Wilsher at an AAHA event held at the University of Auckland Grafton Campus on
May 14th. Congratulations to Lydia and Jade. Their winning project abstracts are
below.
1. Blood pressure response to spirometry: determination of the arterial pressure
response to the forced vital capacity manoeuvre in normal subjects and those with
chronic obstructive pulmonary disease
Lydia Hingston, supervised by Kevin Ellyett, Brooke Cantley and Ken Whyte, Greenlane
Respiratory Clinic
Spirometry lung function testing is a key diagnostic tool which aids in the treatment of
many lung disorders. Spirometry requires a forced vital capacity (FVC) manoeuvre: a
maximal inspiration, forced expiration and a final maximal inspiration. This manoeuvre
may cause transient changes in systemic arterial blood pressure (SABP) (Ruppel,
2009). These SABP changes have not been quantified before, yet there are many
contraindications for spirometry concerning the transient changes in blood pressure
and adverse events, such as risk of aneurysm (Cooper, 2010). The aim of this study
was to observe the changes in SABP with the use of a continuous non-invasive arterial
blood pressure (CNBP) monitor during spirometry in both a normal group (n=20) and a
chronic obstructive pulmonary disease group (COPD) (n=15).
Results: Both groups demonstrated rapid increases in SABP during the forced expiration,
and decreases in SABP during the final inspiration. The systolic pressure increased
during the forced expiration by 31.0 mmHg in the COPD group and 27.7 mmHg in the
control group. No significant differences in pressure changes were observed between
the two groups.
Conclusions: The fluctuations in SABP observed are likely to be less than fluctuations that
occur when people perform Valsalva manoeuvres in their everyday lives, such as when
defecating. These observed transient pressure changes in both the COPD and control
groups were not large and are unlikely to cause an adverse cardiac, cardiovascular or
ocular event. We now have quanfified the SABP changes in two groups and have a
better understanding of the haemodynamic changes during spirometry.
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2. The clinical utility of chest CT in chronic unexplained cough
Jade Lau Young, supervised by Margaret Wilsher and John
Kolbe, Respiratory Department, Auckland City Hospital
Background and objectives: Cough is a common, distressing
symptom and is the most common reason for presentation
to a doctor. In those without satisfactory response to
accepted guideline interventions, additional investigations
(lung function and HRCT) are often performed to exclude less
common pathologies. This study aimed to summarise the
clinical picture of a patient with chronic cough in New Zealand.
It also used lung function testing to reveal the presence of
subtle pulmonary pathology in patients with chronic cough/
Lydia Hingston (left) and Jade Lau Young
(right) with Margaret Wilsher at the
AAHA prizegiving ceremony.
Methods: Patients with chronic, unexplained cough were
recruited retrospectively through the Green Lane Imaging
Database. Patient demographics, cough symptom information, gastro-oesophageal reflux disease (GORD) and
rhinosinusitis symptoms and lung function testing data were
collected. Mann-Whitney tests, t-tests, sign tests and linear
regression were performed using SPSS software.
Results: Patients were 65% female, 92% Caucasian, with
median BMI 27.6 (range 17.8-50.1) and median age 65 (15-82).
38% and 57% of patients reported GORD and rhinosinusitis
symptoms respectively. When analysed as a group, patients
had decreased, abnormal% Predicted FEV1 and FVC on lung
function testing (p<0.001 and p=0.001 respectively) despite
their lung function falling within normal limits when assessed
individually. In this study an obese BMI was shown to have
significant effect upon lung function and BMI was a predictor
for %predicted FVC and FEV1/FVC, but not FEV1 (p=0.036,
0.036 and 0.267 respectively).
Conclusion: This study validated existing ideas of the clinical
picture of a patient with chronic cough. Despite appearing
normal when assessed individually, patients had statistically
significant abnormal lung function tests when analysed as
a patient group. BMI was found to be an important factor
in lung function performance, correlating negatively with
%Predicted FVC and FEV1/FVC.
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The SHIVERS study
Southern Hemisphere Influenza and Vaccine Effectiveness
Research and Surveillance
SHIVERS is an international, multi-disciplinary and multi-agency
collaboration to evaluate influenza disease burden, epidemiology,
aetiology, risk factors and immunology, as well as measuring
the effectiveness of prevention strategies such as influenza
vaccination.
This project is a result of a funding arrangement between the
US Centre for Disease Control (CDC) and the New Zealand crown
research institute Environmental Science and Research (CRI). It aims
for better understanding the burden of influenza and how it is spread
about the world.
The original bid was successful in beating beat all other Southern
Hemisphere applicants because of the collaborative potential
offered by researchers at the ESR, Auckland DHB, Counties-Manukau
DHB, the Universities of Auckland and Otago and Chicago’s St Jude
Children’s research hospital. Lead investigators for Auckland DHB
are paediatrician Cameron Grant, intensivist Colin McArthur and
microbiologist Sally Roberts. A dedicated team of five research nurses
at ADHB who work on this project year round.
Besides the quality of researchers and their collaborative dynamic,
the research team won because of some of the unique features of
both our health system and geography. Here, public hospitals look
after all acute admissions for SARI, giving us great integrity in our
public health database. We also have a good track record in the
early detection of pandemic viruses. Dr McArthur co-ordinated the
national intensive care response to the influenza pandemic in 2009.
The research shows how uniquely well placed a New Zealand team
is to pursue these important objectives in international influenza
patterns and risks. It has drawn a number of mini-conferences and
international visitors to New Zealand, where CDC staff are now
frequent visitors. SHIVERS is in its fourth year and the team looks
forward to pursuing a set of objectives out onto 2016.
Conclusions: The fluctuations in SABP observed are likely to be
less than fluctuations that occur when people perform Valsalva
manoeuvres in their everyday lives, such as when defecating. These
observed transient pressure changes in both the COPD and control
groups were not large and are unlikely to cause an adverse cardiac,
cardiovascular or ocular event. We now have quanfified the SABP
changes in two groups and have a better understanding of the
haemodynamic changes during spirometry.
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Awards
Auckland DHB
Research Excellence
Awards
This award, offered annually in conjunction
with ADHB Healthcare Excellence Awards,
recognises lead authors of significant, original
research papers published in the preceding
year. Applications are judged by a panel of top
researchers for contribution to new knowledge,
potential to inform best practice, stakeholders
and clinical decision making, and potential to
improve healthcare delivery.
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2012 Joint Winner
2012 Joint Winners
Dr Deborah Williamson – Department of Clinical
Microbiology, LabPlus, Auckland City Hospital, for her
paper “Clinical failures associated with rpoB mutations in
phenotypically occult multidrug-resistant Mycobacterium
tuberculosis” (Int J Tuberc Lung Dis. 2012 Feb;
16(2):216-20. doi: 10.5588/ijtld.11.0178)
Drs Bo Remenyi and Nigel Wilson – Paediatric and Congenital
Cardiac Service, Starship Children’s Hospital, for their paper
“World Heart Federation criteria for echocardiographic
diagnosis of rheumatic heart disease—an evidence-based
guideline” (Nature Reviews Cardiology 9, 297-309 (May 2012)
| doi:10.1038/nrcardio.2012.7)
Dr Deborah Williamson and team.
Dr Bo Remenyi and Nigel Wilson.
Using molecular tests that detect mutations causing resistance
to rifampicin, one of the main drugs used against Mycobacterium
tuberculosis, the team found that some of these gene mutations
were not detected by conventional methods. There was also a
significant association between the presence of these mutations
and tuberculosis treatment failure. Following this research,
genotypic testing has been adopted as standard in the Clinical
Microbiology Laboratory. This has allowed earlier detection and
treatment of several cases of MDR-TB sooner than would have
been using conventional susceptibility test results.
The international rheumatic heart disease (RHD) standardisation
project aims to support the effectiveness of screening as a
strategy by establishing echocardiographic changes that are
indisputably rheumatic heart disease. RHD is the most serious
complication of acute rheumatic fever (ARF) and is a significant
cause of mortality and morbidity in New Zealand with 800
admissions to hospitals and 200 deaths per year. Rates for Māori
and Pacific Island peoples are among the highest in the world.
Globally, RHD is the most common cause of acquired heart
disease in children and young adults. Long-acting penicillin is
effective to prevent mild RHD from progressing to severe disease
thus avoiding cardiac surgery. Portable echocardiography allows
detection of mild (often subclinical) RHD, but many different
criteria have been used internationally.
These findings also have international public health significance,
as they suggest that the global prevalence of MDR-TB may be
greater than is currently estimated.
The standardised criteria aim to permit rapid and consistent
identification of individuals with RHD without a clear history
of acute rheumatic fever and reduce false positive diagnoses.
They are evidence-based guidelines that are now being
recommended as best practice.
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2013 Winner
2014 Winner
Dr Stuart Dalziel – Children’s Emergency Department,
Starship Children’s Hospital, for his paper “Predictors of
severe H1N1 infection in children presenting within Pediatric
Emergency Research Networks (PERN): retrospective
case-control study” (BMJ 2013;347:f4836).
Dr Catherine Han – Medical Oncology, Regional Cancer and
Blood Service, Auckland City Hospital, for her paper “Phase
I drug-interaction study of effects of calcium and magnesium
infusions on oxaliplatin pharmacokinetics and acute
neurotoxicity in colorectal cancer patients” (BMC Cancer
2013, 13:495 doi:10.1186/1471-2407-13-495).
Dr Stuart Dalziel
and team.
This study has identified six risk factors associated with severe
outcomes in children presenting to emergency departments
with influenza-like illness. The study identified 321 children with
severe outcomes (including death or admission to intensive
care) due to H1N1 infection at 79 sites in 12 countries, from a
global consortium of paediatric emergency medicine networks
during the first season of the H1N1 pandemic in 2009. Of
these 265 (83 per cent) presented to emergency departments
with Centres for Disease Control and Prevention defined
symptoms of influenza-like illness and were matched with
random and age-matched controls with influenza-like illness
who did not have severe outcomes. The risk factors identified
include two chronic disease factors (chronic lung disease,
cerebral palsy/developmental delay) and four physiologic or
physical examination factors including requirement for oxygen,
tachycardia relative to age, signs of chest retractions and
dehydration.
The study is the largest international study of severe paediatric
outcomes with H1N1. The data is applicable both in times of
a pandemic and during routine influenza seasons. In addition
to identifying the six risk factors, this study involved the
establishment of a new research network – Paediatric Emergency
Research Networks (PERN) comprised of representative hospitals
from the five major paediatric emergency medicine research
networks located in Europe, Middle East, North America (one
each from Canada and USA) and Australasia – that has access to
data from over three million paediatric emergency department
presentations annually from more than 100 hospitals in four of
the six World Health Organisation regions.
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Dr Catherine Han
and team.
Dr Catherine Han undertook research within Auckland City
Hospital’s medical oncology department, one of Australasia’s
largest cancer treatment centres, to understand if calcium and
magnesium infusions had any effect on reducing the debilitating
neurotoxicity on patients caused by a commonly used
chemotherapy drug, oxaliplatin. Oxaliplatin is regularly used for
treating various forms of cancer, but often causes nerve damage
that leads to the treatment being reduced in dose or stopped
prematurely. Quality of life is reduced for cancer patients due
to its side effects.
The practice of giving calcium and magnesium infusions to
counter the debilitating neurotoxicity of oxaliplatin is currently
used by many oncologists worldwide. Dr Han and her team
introduced a double-blind, placebo-controlled, cross-over study
which evaluated the effectiveness of these infusions in cancer
patients. The finding was that the calcium and magnesium gave
no protective effects for the oxaliplatin-induced neurotoxicity.
Based on the results of the study, the use of the infusions
has been withdrawn from Auckland City Hospital’s Oncology
Department. This has improved patient contact time, by
significantly reducing the treatment time required by oncology
nurses. The other key benefit is a large saving every year in
health dollars across the department.
Current Research
ADHB researchers are instigators and leaders
of projects in almost all clinical and support
services of the organisation. Many participate
in international, collaborative, multi-centre
studies, and in commercially funded clinical
trials of pharmaceuticals and medical devices.
ADHB also provides essential resources and
partner¬ships for researchers from other
organisations.
Below is presented a snapshot of the 904 new
research projects that commenced at ADHB
in 2012 through 2014, along with the lead
investigator.
17
Allied Health – Audiology, Nutrition, Pharmacy,
Shelley Myers - A comparaison of the effectiveness of
tympanometry measures in Down’s Syndrome children
Eamon Duffy - Anti-microbial usage point prevalence study
Lydia O’Connor - Assessing babies’ speech development
using the IMP (Infant Monitor of vocal Production)
Physiotherapy, Social Work, Speech & Language:
Eamon Duffy - Outpatient intravenous anti-microbial
(OPIVA) treament and outcome review
Alison Forbes - Clinical audit of compliance with Pharmac’s
restrictions on hospital medicines list medicines
Alison Forbes - Clinical audit of compliance with Pharmac’s
restrictions on Hospital Medicines List medicines: infliximab
Lynn Gillanders - Quality of care: experience of an adult
HPN patient
Meghann Grawburg - A quantitative investigation into thirdparty disability in family members of people with aphasia:
The second phase of a mixed methods study
Peter Huggard - A hidden jewel: social work in primary care
practice in Aotearoa New Zealand
Nicola Saywell - Gaining perspectives of people with stroke,
to inform development of a group exercise programme
David Welch - Cortical auditory evoked potentials in
response to frequency-specific speech tokens measured in
infants
Anaesthesia:
Adult, Cardiothoracic, National Women’s and ORL:
Vanessa Beavis - International observational cohort study of
complications following elective surgery
Andrea Kelly - ‘The Self-Esteem of Children with Hearing
Impairment
Alan Broderick- A novel, non-invasive device for the
estimation of stroke volume compared with the continuous
thermodilution technique using a pulmonary artery
catheter
Eddie Kim - ADHB surgical VTE prophylaxis: second snapshot audit
Alan Broderick - The use of bivalirudin in the management
of unanticipated heparin resistance during cardiac surgery
Helen Lo - A study of venous thromboembolic events in
surgical patients at Auckland District Health Board
Alan Broderick - Aorto-atrial fistula visualised using 3D
transoesophageal echocardiography
Sandra McLellan - Can dietitians reduce interdialytic weight
gain in at risk haemodialysis patients through tailored
education on dietary sodium intake?
Douglas Campbell - NeuroVISION study- Neurological
Impact of Vascular events In noncardiac Surgery
Anna Miles - Airway responsiveness to aspiration of thin
and thickened fluids and its relationship with clinical
outcomes
Anna Miles - Swallowing difficulties in people following
cardiac surgery and lung transplant surgery
Anna Miles - Patterns of swallowing impairment in a paediatric videofluouroscopic swallow study (VFSS) caseload
18
Suzanne Purdy - Perception of Speech Prosody in Children
with Hearing Loss
Grace Chang - Oxytocin infusion audit in association with
elective Caesarian section
David Cumin - Factors determining successful information
transmission at patient handover: Information salience
survey
David Cumin - Mining intraoperative physiological data:
interrogating the information that is routinely collected
Daniel Devcich - A psychometric and pragmatic evaluation
of a behaviourally anchored rating scale for measuring the
use of the WHO Surgical Safety Checklist
Matthew Drake - EROS: Enhanced Recovery in Obstetric
Surgery- Effect of a new care pathway on patient outcomes
Kerry English - Cancelling Elective Surgery: A Mixed
Methods Study of the Impact on Quality of Life,
Postoperative Outcomes and Patient’s Socioeconomic
Standing
Robert Fry - A retrospective survey of substance abuse in
anaesthetists in Australia and New Zealand
Setareh Ghahreman - Epidural response times at National
Women’s Hospital: an audit of current practice
Veronica Gin - Improving pre-operative anaesthesia
information delivery and communication on Level 8
Anaesthesia via patient survey
Kerry Gunn - The Massive Transfusion Registry
Kerry Gunn - Retrospective audit for prevalence of Iron
Deficient Anaemia at Auckland City Hospital
Kerry Gunn - Retrospective audit to understand Blood
Transfusion Rates for elective procedures in Adult Patients
within Auckland City Hospital and Greenlane Clinical Centre
Kathryn Hagen - Measurement of Exercise Tolerance for
Surgery (METS) Study
Jack Hill - Intrathecal morphine analgesia: outcome
measures after caesarian section
Jack Hill - Serial TEG® and corresponding Plasma
Fibrinogen: A National Womens compliance audit
Timothy Holliday - Comparison of Assessment of residual
regurgitation following Mitral Valve Repair between the
immediate post repair transesophageal echocardiogram
and follow up transthoracic echocardiogram
Nicola Hooper - Outcomes in Patients with Aortic Stenosis
Undergoing Anaesthesia in Auckland City Hospital in 20092010 (or Outcomes in Aortic Stenosis Audit 2009-10)
James Houghton - Ultrasound guided brachiocephalic vein
cannulation; an audit of practice
Kim Jamieson - Mastectomy pain audit: Retrospective audit
of the incidence of persistent pain >6months post surgery
for mastectomy patients
Steven Kim - Preoperative ACE inhibitor and Angiotensin
receptor antagonist Management
Steven Kim - Preoperative Exercise Testing Study
(Retrospective Observation)
Beau Klaibert - A Review of Surgical Venous
Thromboembolic Prophylaxis at Level 8 Operating Theaters
at Auckland City Hospital
Cornelis Kruger - Advance Targeted Transfusion in Anaemic
Cardiac Surgical patients for Kidney Protection (ATTACK II:
Feasibiltiy Chart Review)
Cornelis Kruger - Blood Glucose during Cardiopulmonary
Bypass Surgery: An Audit Pre & Post Standardisation of
Cardioplegia Glucose Content
Cornelis Kruger - Propofol vs. Etomidate: Is Etomidate
Haemodynamically Superior for Induction of Patients
Undergoing Cardiac Surgery: a randomised, controlled
blinded trial.
Neil MacLennan - Prognostic implications of elevated
preoperative high-sensitivity Troponin T in vascular surgery
patients
Manisha Mistry - Propofol vs etomidate use in cardiac
surgery; a retrospective audit of clinical databases: is there
a difference in mortality?
Mark Moll - Multidisciplinary audit of local anaesthesia use
and knowledge of presentation and management of local
anasethetic toxicity
Mark Moll - Audit of practice and multidisciplinary
knowledge of intrauterine resuscitation at National
Women's Hospital, Level 9, Auckland City Hospital
19
Anaesthesia: continued
Aurance Nkosinathi Mdladla - Audit of the usage of
activated recombinant factor 7 (rFVIIa) on Level 4 theatres
Felicity Pugh- Restrictive Versus Liberal Fluid Therapy in
Major Abdominal Surgery
Catherine Purdy- An Evaluation of the Stress Factors of
Practicing Anaesthesia within New Zealand and Australia
Jeffrey Reddy- The incidence of rocuronium related
anaphylaxis in Auckland
Jonathan Wallace – Retrospective opioid audit
Guy Warman- Light treatment for sleep and circadian
disruption in kidney donor patients
Jennifer Weller - Evaluating the multidisciplinary operating
room simulation training course
Glyn Richards- Retrospective audit of maternity patients
receiving mexiletine during pregnancy for neuropathic pain
Jennifer Weller - Review of patient notes for surgical
complications to evaluate the effectiveness of
an educational intervention aimed at improving
interdisciplinary communication in the operating room
Neil Robertson- Adult perioperative fluid therapy audit
Daniel Wood - Fraction Inspired Oxygen Survey
Tim Short- Pharmacokinetic-Pharmacodynamic modelling
of Sevoflurane: Single centred prospective unblinded
descriptive study
Anaesthesia (Starship):
Michelle Soakell-Ho- Improving Informed Consent in
Anaesthesia with IT Mediated Risk Disclosure in the
Preoperative Period
Michelle Soakell-Ho- The Auckland Review of Surgical
Outcomes Study (TAuRoS): a single centre, retrospective
cohort study of postoperative outcomes for patients
undergoing non-cardiac surgery
Paul Baker - An educational evaluation of the Orsim
bronchoscopy simulator to differentiate between groups
of anaesthetists with different levels of bronchoscopy
experience
Sue Pickup - A retrospective audit of paediatrics attending
the complex pain clinic at Starship
Lena Tan – Perioperative anaesthetic assessment
Martin Steynor - Antacid prophylaxus in obstetrics: an audit
of current practice
Wei Chung Tong- Prospective randomized single blind
control trial of Catheter assisted nasotracheal intubation in
children to minimize nasopharyngeal trauma
Ghassan Talab - Retrospective observational study of postoperative temperatures in elective cardiac surgery patients
Wei Chung Tong - Does using Ligasure reduce seroma rates
in SLNB, and node dissection (ALND and GD)?
Andrew vander Poll - Database for perioperative risk
associated with aortic stenosis (AS) in non-cardiac surgery
Joreline van der Westhuizen - Retrospective audit of
activation of Massive Transfusion Protocol for large
obstetric bleeds
Joreline van der Westhuizen - Retrospective audit of
perioperative management of diabetic patients
20
Yvonne Wagner- Anaesthesia outcomes in the morbidly
obese obstetric patient
Cardiology (Adult):
Angela Barnes - Pacific Best Practice Cardiac Rehabilitation
Project
Jocelyne Benatar - A Multicenter, Randomized, DoubleBlind, Placebo-Controlled, Phase 3 Study to Evaluate
Cardiovascular Outcomes of TAK-875, 50 mg in Addition to
Standard of Care in Subjects with Type 2 Diabetes
Jocelyne Benatar - A Phase III, multicentre, international,
randomised, parallel group, double blind cardiovascular
safety study of BI 10773 (10 mg and 25 mg administered
orally once daily) compared to usual care in type 2 diabetes
mellitus
Jocelyne Benatar - Assessment of Clinical Effects of
Cholesteryl Ester Transfer Protein Inhibition with Evacetrapib in Patients At a High-Risk for Vascular Outcomes
Jocelyne Benatar- A Randomized, Double-Blind, PlaceboControlled, Multicenter Study to Assess Cardiovascular
Outcomes Following Treatment with MK-3102 in Subjects
with Type 2 Diabetes Mellitus: OMNEON
Jocelyne Benatar- Trans fatty acid analysis in vegans
Jocelyne Benatar - A Randomized, Double-blind, Placebocontrolled, Parallel-group Study to Evaluate the Effect of
Long-term Treatment with BELVIQ (lorcaserin HC1) on
the Incidence of Major Adverse Cardiovascular Events
and Conversion to Type 2 Diabetes Mellitus in Obese
and Overweight Subjects with Cardiovascular Disease or
Multiple Cardiovascular Risk Factors
Robert Doughty- Protocol GC28210. A phase II,
randomised, placebo controlled, double-blind study of the
safety and efficacy of MPSK3169A in patients with coronary
heart disease or high risk of coronary heart disease
Robert Doughty- Renal Denervation for Heart Failure with
Preserved Ejection Fraction
Robert Doughty- REDUC LAP-HF (A Study to evaluate the
DC Devices Inc IASD System II to REDUCe Elevated Left
Atrial Pressure in patients with Heart Failure)
Roberty Doughty - A Randomized, Double Blind, Placebo
Controlled, Parallel Group Study Evaluating the Efficacy
and Safety of Alirocumab in Patients with Primary
Hypercholesterolemia not treated with a statin
Robert Doughty - A randomised, controlled trial to
determine whether intensive behavioural and medical
management and/or renal denervation will reduce blood
pressure in real-world patients with resistant hypertension,
and whether the two approaches achieve a similar benefit
Elizabeth Broadbent - Improving patients’ understanding
of their heart condition through the use of drawings of the
heart
Robert Doughty - The Imperative- HF trial (Intensified
Management using PERidishArge Biomarker Testing and
InterVention in cute heart failure). RCT comparing peridischarge management of acute decompensated heart
failure (ADHF) with usual clinical care
Arthur Coverdale - Acute myocarditis: our experience at
Auckland City Hospital 2003-2012
Chris Ellis- Australian and New Zealand Cardiac Society
Acute Coronary Syndrome Audit: ANZ Snapshot 2012
Arthur Coverdale- Retrospective Chart Review of
Percutaneous Mitral Valvuloplasty in Pregnancy
Jane Hannah- The use of continuous subcutaneous
frusemide in decompensated heart failure: can it achieve a
diuresis?
Brett Cowan- Multicenter open-label study to evaluate
efficacy of gadobutrol-enhanced cardiac magnetic
resonance imaging (CMRI) for detection of significant
coronary artery disease (CAD) in subjects with known or
suspected CAD by a blinded image analysi
Paul Davis - Paramedic Initiated Helivac to Tertiary Hospital
for Primary Percutaneous Coronary Intervention: A new
Approach in the Management of ST-Elevation Myocardial
Infarction Patients
Margaret Hood - A Usability Study of the MoMe
Continuous ECG Monitoring and Arrhythmia Detection
System
Kerryanne Johnson - Repeat balloon aortic valvuloplasty
and its role in the TAVI era
Nigel Lever - Cardiac Resynchronisation therapy (CRT) and
A-V Node ablation in AtrialFibrillation
21
Cardiology (Adult): continued
Nigel Lever - PROTECT-ICD Trial: Programmed Ventricular
Stimulation to Risk Stratify for Early CardioverterDefibrillator (ICD) Implantation to Prevent Tachyarrhythmias
following Acute Myocardial Infarction
Shyam Sankaran - Cardiac MRI at Auckland City Hospital:
Experience from 2003-2012
Boris Lowe- Retrospective review of cardiac MRI diagnoses
for investigation of elevated troponin in angiographically
normal coronary arteries
Gnalini Sathananthan - Assessment of right ventricular
volumes over time in patients following atrial switch repair
Ralph Maddison - REMOTE-CR: Remote Exercise Monitoring
Trial for Exercise-based Cardiac Rehabilitation
Janarthanan Sathananthan- Risk assessment and outcomes
in patients >80years old undergoing isolated aortic valve
replacement
Steph Madenholt-Titley - Retrospective observational
elective cardioversion audit
Chris Occleshaw - Audit in the use of cardiac CT scanning in
children with congenital heart disease in ADHB 2010-2013
John Ormiston- NG PROMUS A Prospective, Multicenter
Trial to Assess the NG PROMUS EverolimusEluting Platinum
Chromium Coronary Stent System (NG PROMUS Stent
System) for the Treatment of Atherosclerotic Lesion(s)
Janarthanan Sathananthan- Coronary artery bypass
grafting in asymptomatic dialysis patients prior to renal
transplantation
Warren Smith- Is the benefit/risk ratio for cardiac
defibrillators implanted in older populations (age 75) still
favourable? Protocol, v#1, 15/3/12
Warren Smith - Sternal ECG Patch Comparison Trial
Cathrine Patten - Evaluating the Rate of Undiagnosed Type
2 Diabetes in Patients Referred for Outpatient Coronary
Angiograms (ERUPT)
Ralph Stewart- Evaluation of a point score for assigning
surgical priority for patients with severe heart valve disease
at Auckland District Health Board
James Pemberton - Retrospective study of infective
endocarditis at Auckland City Hospital 2005-2011
Ralph Stewart- A Randomized, DoubleBlind, Placebo
Controlled, ParallelGroup Study to evaluate the effect of
SAR236553/REGN727 on the occurrence of cardiovascular
events in patients who have recently experienced an Acute
Coronary Syndrome
James Pemberton- Retrospective study of Trastuzumab
induced cardiotoxicity at Auckland City Hospital
Peter Ruygrok- A randomized, controlled study to evaluate
the safety and cardiovascular effects of Algisyl-LVR™ as a
method of left ventricular augmentation in patients with
dilated cardiomyopathy (AUGMENT-HF)
Peter Ruygrok- Effectiveness of previously cannulated radial
arteries as conduits for coronary artery bypass surgery
Peter Ruygrok - Outcome following heart transplantation
in Maori and Pacific Island patients: a comparison with
European New Zealanders
Peter Ruygrok – The AVERT Trial
22
Peter Ruygrok - Confocal laser scanning microscopy for
assessment of cardiac allograft rejection
Ralph Stewart - Prevention of Serious Adverse Events
following Angiography: A department of Veteran Affairs
Cooperative Study
Ralph Stewart - International study of comparative health
effectiveness with medical and invasive approaches
Ralph Stewart - A Clinical Outcomes Study to Compare
the Incidence of Major Adverse Cardiovascular Events in
Subjects Presenting with Acute Coronary Syndrome Treated
with Losmapimod Compared to Placebo
Tom Wang- Myocardial infarction associated with Coronary
Artery Bypass Grafting (Type 5 MI) as detected by highsensitivity troponin T (hsTn-T)
Tom Wang - High sensitivity troponins and outcomes in
patients admitted to coronary care unit
Cara Wasywich- Does diastolic pulmonary gradient alter
haemodynamic assessment of suitability for cardiac
transplantation?
Cara Wasywich - A feasibility study of cardiac
haemodynamic assessment by cardiac catheterisation
augmented with cardiac MR imaging
Timothy Watson- Diagnostic yield of elective coronary
angiography
Mark Webster - ACIST Diagnosis of Coronary Arterial
Disease with a Rapid Exchange Monorail Pressure Sensor
(MPS) for the Measurement of Fractional Flow Reserve
(FFR) Protocol No: NZ100"
Mark Webster - Treatment of rEsistant hypertension using
a radiofrequency percUtaneous transluminal angioplasty
CathetEr
Mark Webster- Intra-coronary Cooling (Evaluation of
Outcomes) Before Angioplasty Revascularisation in ST
Elevation Myocardial Infarction (ICEOBAR-STEMI)
Mark Webster- International, Non-randomized, First-InHuman Study of the EnligHTN Generation 2 System in
Patients with Drug-Resistant Uncontrolled Hypertension
Mark Webster- Safety & Performance Study of the
ReZolve2 Sirolimus-Eluting Bioresorbable Coronary Scaffold
– RESTORE II Trial
Mark Webster- EVOLVE II QCA Trial- A clinical study to
assess angiographic and intravascular ultrasound outcomes
of the SYNERGY™ Stent System for the treatment of
narrowed coronary artery
Mark Webster - Neuromodulation for uncontrolled
Hypertension
Mark Webster - Understanding the effects of localized intracoronary hypothermia on ischaemia and microvascular
function
Mark Webster - A First In Human (FIH) study to assess
safety and performance of hepatic sympathetic denervation
for treatment of inadequately controlled type 2 diabetic
subjects on oral anti-hyperglycemic agents
Cynthia Wensley - Patient comfort after cardiac surgery- an
evidence-based, patient-centred approach
Jonathon White - Understanding troponin elevations in
acute exacerbation of chronic obstructive pulmonary
disease: a cardiac magnetic resonance imaging study
Alistair Young- Peak Heart Rate during Upright Treadmill
and Supine Cycling
Alistair Young - Assessment of 3D heart shape in congenital
heart disease
Cardiology (Starship):
Luke Eckersley - Epidemiology of important congenital
heart disease in New Zealand
Tom Gentles - Fontan liver and renal study
Tim Hornung - Long term outcomes after arterial switch
operations for transposition of the great arteries
Luciana Marcondes- Progression of right ventricular dilation
after repair of tetralogy of Fallot- medium term follow up
Musthafa Janeel Moosa - Scimitar Syndrome: single centre
experience
Beau Pontre - Innovative MRI assessment of myocardial
geometry and fibre architecture in ex vivo congenital heart
disease (CHD) specimens
Kathryn Rice - Echocardiographic Review of Dynamic
Diastolic Function and Preload Markers in Fontan Patients
Jon Skinner - New Zealand experience of an Epicardial
approach to Implantable Cardiac Defibrillators in children
Jon Skinner - Targeted Next Generation Sequencing to
identify the genetic causes of heritable cardiac disorders
23
Cardiology (Starship): continued
Jon Skinner - The physical and psychological consequences
of left cardiac sympathetic denervation in the management
of long QT syndrome and catecholaminergic ventricular
tachycardia
Jon Skinner - Wolff-Parkinson-White Syndrome and Sudden
Death
Nigel Wilson - The significance of rheumatic heart disease
detected by echocardiography
Cardiothoracic Surgical Unit:
Indran Ramanathan - The safety and efficacy of dorsal root
replacement in the treatment of patients with aortic root
pathology
Indran Ramanathan - Understanding the carbon footprint
of cardiothoracic surgery
Tim Willcox - Perfusion Down Under Collaboration
Database
Tim Willcox- Reducing red blood cell transfusion in cardiac
surgery: a multicentre quality improvement initiative of the
Perfusion Downunder Collaboration (using PDUC Database)
Tim Willcox - The Goal dIrected perFusion Trial: A multicenter, prospective, randomized, controlled study
Cardiovascular
Intensive Care Unit:
Fleur Bethell - A pilot study to evaluate the effect of a
brief psycho-education intervention in Cardiac Intensive
Care Unit survivors with Post Traumatic Stress Disorder
symptomatology
David Buckley - Clinical Usability Assessment of the 95X
Humidifier
Eileen Gilder - Audit of practice: Theraputic Hypothermia
Michael Gillham- A randomised, double-blind, multi-centre
placebo controlled trial of dexmedetomidine for patients
with agitation and delirium in the intensive care unit
(DahLA)
24
Michael Gillham- MicroRNA biomarkers for the early
diagnosis of Non Occlusive Mesenteric Ischaemia
Chang Joon Kim- Prevalence of preoperative anaemia in
patients having cardiac surgery and its impact on clinical
outcome
Shay McGuinness - Analgesic, Sedative and Antibiotic
Pharmacokinetics during Extra Corporeal Membrane
Oxygenation : Understanding altered pharmacokinetics to
improve outcomes
Shay McGuinness - Fluid therapy after cardiac surgery- a
feasibility study
Shay McGuinness - A Multicenter, Open-Label, Randomized
Study to Compare the Safety and Efficacy of Intravenous
Ceftolozane/Tazobactam with that of Piperacillin/
Tazobactam in Ventilator Associated Pneumonia
Shay McGuinness- Trial of early activity and mobility in ICU
Shay McGuinness- Prophylactic Intra-aortic Balloon
Counterpulsation in High-Risk Cardiac Surgery: An inception
cohort study (PINBALL)
Shay McGuinness- Therapeutic hypercapnia after cardiac
arrest: a pilot feasibility and safety randomized controlled
trial
Shay McGuinness- Supplemental Parenteral Nutrition in
Critically Ill Patients: A Pilot Randomised Controlled Study
Shay McGuinness- Pilot randomised controlled trial of early
mobilisation in critically ill patients to improve functional
recovery and quality of life
Shay McGuinness- A multi-centred randomised cross over
trial investigating the safety and efficacy of using 0.9%
saline or Plasma Lyte® 148 as the primary resuscitation fluid
in adult intensive care patients
Shay McGuinness - A Prospective, Randomized, DoubleBlind, Multicenter, Phase 3 Study to Assess the Safety and
Efficacy of Intravenous Ceftolozane/Tazobactam compared
with Meropenem in Adult Patients with Ventilated
Nosocomial Pneumonia
Shay McGuinness - The Fluid Translation of Research into
Practice Study: An International Cross-Sectional Survey of
Fluid Resuscitation Practice
Colin McArthur- Practice pattern variation in discontinuing
mechanical ventilation in critically ill adults: an international
prospective observational study (IOSWeaning)
Shay McGuinness - A Phase 3 Randomized Double-blind
Study Comparing TR 701 FA and Linezolid in Ventilated
Gram-positive Nosocomial Pneumonia
Colin McArthur - Early goal-directed sedation in
mechanically ventilated intensive care patients SPICE
Kate Ormrod- Nutrition Therapy in adults requiring ECMO
in Australia and New Zealand
Rachael Parke- Fluid therapy after cardiac surgery
Rachael Parke- A study to describe the airway pressures
generated by a wide range of flows provided by high flow
humidified nasal oxygen therapy and the effect on regional
lung ventilation. (SHOT study)
Rachael Parke- Fluid challenges in intensive care: how do
we administer fluids in the ICU? (FENICE trial)
Janarthanan Sathananthan- The appropriateness of
discharge medications at time of discharge from cardiac
surgery: A 1 year audit
Colin McArthur - Stress ulcer prophylaxis in the intensive
care unit. A multicentre inception cohort study (SUP-ICU)
Colin McArthur - A week in the neurocritical care unit:
point prevalence observational study in neurocritical care:
PRINCE study
Colin McArthur - Pre-hospital Anti-fibrinolytics for
Traumatic Coagulopathy and Haemorrhage (PATCH) Study
Lynette Newby - Large observational study to Understand
the Global Impact of Severe Acute respiratory FailurE
Janine Rouse- Discharge delay for Critical Care patientsStaff perspectives of the impacts on patients and staff
Dermatology:
Critical Care Medicine:
Steven Lamb – Australasian Psoriasis registry
Doug Elliott - Ventilator Associated Pneumonia: developing
consensus for a pragmatic 'clinical surveillance' definition
and measuring current incidence in Australian and New
Zealand ICUs
Harriet Cheng - Dermatology In-patient Service Review
Colin McArthur- The CLARITY study: an audit of
temperature regulation in intensive care patients with
traumatic brain injury and stroke in Australia and New
Zealand
Colin McArthur- A randomised blinded placebo controlled
trial of hydrocortisone in critically ill patients with septic
shock
Colin McArthur - Standard issue transfusion versus fresher
red blood cell use in intensive care
Colin McArthur - Southern Hemisphere Influenza vaccine
effectiveness, research and surveillance (SHIVERS):
Objective 1- Hospital-based surveillance for severe acute
respiratory infections caused by influenza and other
respiratory pathogens
Harriet Cheng - Effect of topical corticosteroid therapy
under occlusion on endogenous cortisol production
Diabetes Service:
Melanie Beatty - Where do adolescents with diabetes
currently get their information from about risk reduction
education?
Tim Cundy/Jasmine Tan - Remission rates with aggressive
antihypertensive regimen: Case series of 36 patients from
Langimalie Clinic
Rosie Dobson - Cross sectional survey of the use of mobile
health interventions in young people with type 1 diabetes
Anna Friis - Does Kindess Matter? A Randomised Controlled
Trial investigating the role of self-compassion in reducing
depression and improving compliance in diabetes patients
25
Diabetes Service: continued
Manish Khanolkhar - Audit on inpatient hypoglycaemia
management in adult Diabetes Mellitus subjects admitted
to Auckland City Hospital
Manish Khanolkhar - Retrospective clinical audit to
estimate the level of metabolic control and the prevalence
of diabetes complications in patients with diabetes mellitus
attending the Auckland DHB Young Adult Diabetes Clinic
Annika Lam- Audit on medium term diabetes outcomes
and insulin prescribing patterns at the Auckland Diabetes
Centre
Jasmine Tan – Five year longitudinal study of native renal
biopsies in patients with type 2 diabetes in the Auckland
Region
Jasmine Tan- Survival and cardiovascular outcomes in
patients with type 2 diabetes and end stage renal disease
on dialysis – A retrospective observational study
Bernard Venn- Postprandial glycaemia in Asian type 2
diabetics
Ben Wheeler - Evaluating the insulin pump discontinuation
action plan- impact on patient and family confidence,
anxiety and knowledge
Fiona Wu- Auckland and Waitemata District Health Boards
Diabetes Retinal Screening Outcomes Cohort Study
Fiona Wu - Audit of patients with Type 2 Diabetes and
hospital admissions with cellulitis between 1 Jan 2011- 31
Aug 2013
Emergency (Adult):
Peter Jones - The Asia, Australasia and New Zealand
Dyspnoea survey in the EMergency departments
(AANZDEM study)
Sinan Kamona - New Zealand Emergency Medicine
Network ED Airway Registry of NZ Emergency Department
Airway Practices
Acrane Li - Impact of pre-operative imaging on the
surgical outcome of Emergency Department patients with
suspected appendicitis
26
Timothy Tenbensel - Evaluating the Auckland After Hours
Initiative
Emergency (Starship):
Chris Bullen - Opportunistic Provision of Smoking Cessation
Support at Children’s Emergency Department, Starship,
Auckland City Hospital
Joanne Cole - A Fitness for Purpose Study of the Field
Assessment Conditioning Tool (FACT)
Stuart Dalziel - Paediatric Emergency Research- HRC
Fellowship
Stuart Dalziel - The A-PHIRST study (Australasian Paediatric
Head Injury Rules Study): a prospective observational study
comparing existing paediatric minor head injury clinical
decision rules
Stuart Dalziel - Utilisation of cranial computed tomography
scanning for paediatric head injury in Australasia
Stuart Dalziel - Convulsive Status Epilepticus Paediatric Trial
(ConSEPT) Study
Stuart Dalziel - Global Pediatric Emergency Poisoning
Surveillance System
Stuart Dalziel - Pharmacotherapy Practice Patterns and
Outcomes in Bronchiolitis in the America’s, Australia/NewZealand and Europe
Stuart Dalziel - Ibuprofen and Paracetamol in Asthma
Causation (iPAC) feasibility study
Stuart Dalziel - Bell’s Palsy in Children: A Retrospective
Chart Review
Bernard McCarthy - A prospective analysis of children, with
infection and requiring fluid bolus, in the Starship Children's
Emergency Department
Michael Shepherd - Refreshing Cardio-Pulmonary
Resuscitation using In-Situ Training (ReCPR-IST)
Endocrinology (Adult):
Tim Cundy - Randomised Trial of Genetic Testing and
Targeted Zoledronic acid Therapy to Prevent SQSTM1
Mediated Paget’s Disease (Zoledronate in the Prevention of
Paget’s)
Maritza Farrant - The management and outcomes of
prolactinomas in pregnancy
Keith Petrie- Do Bone Models Help Patients Better
Understand Osteoporosis (The Model Study)
Endocrinology (Starship):
Wayne Cutfield - The incidence of new-onset DKA in
children with T1DM in Auckland 2000 – 2009
Paul Hofman- Can lifestyle changes during pregnancy
improve pregnancy outcomes and protect offspring from
the effects of an obesogenic environment
Paul Hofman - Efficacy and safety of liraglutide in
combination with metformin versus metformin
monotherapy on glycaemic control in children and
adolescents with type 2 diabetes
Craig Jefferies - Clinical trial of Zoledronic acid (Aclasta)
in children and adolescents with Duchenne muscular
dystrophy
Gastroenterology (Adult):
Dagmar Hendel - Utility of upper gastroscopy in the setting
of frank PR bleeding
Mark Lane - A MC, Rand. DB, Placebo-Controlled, ParallelGroup Study of Oral CP-690,550 As An Induction Therapy in
Subjects With Moderate To Severe Ulcerative Colitis
Mark Lane - A MC, Rand. DB, Placebo-Controlled, ParallelGroup Study of Oral CP-690,550 As A Maintenance Therapy
In Subjects With Ulcerative Colitis
Mark Lane - A MC, OL Study of CP-690,550 In Subjects With
Moderate To Severe Ulcerative Colitis
Mark Lane - A study to determine patient specific and
general beliefs towards medication and their treatment
compliance to selected systemic therapies in chronic
inflammatory diseases (ALIGN)
David Orr - Very low calorie diet (VLCD) followed by fibre
and probiotic supplementation is superior to VLCD alone
in achieving sustained weight loss and resolution of NonAlcoholic Fatty Liver Disease.
David Orr- Very low calorie diet (VLCD) followed by fibre
and probiotic supplementation is superior to VLCD alone
in achieving sustained improvement in weight loss and the
metabolic syndrome post Liver Transplant.
David Rowbotham - The prevalence and management of
Eosinophilic Oesophagitis in NZ
David Rowbotham - Does acute appendicitis over the age
of 40 years correlate with increased risk of developing
colorectal cancer: a ten year retrospective review at ADHB
Yuriko Wilkins- Is increased oral hydration during bowel
preparation associated with improved clarity and quality of
bowel cleansing?
Gastroenterology (Starship):
Ross Anthony - Faecal Calprotectin as a non-invasive
biochemical marker of inflammatory bowel disease in the
paediatric population
Jonathan Bishop - Prospective Study to assess validity of
the use of serological markers to diagnose Coeliac Disease
in New Zealand children according to ESPGHAN diagnostic
guidelines
Helen Evans - Do New Zealand babies with biliary atresia
present to specialist services later than in overseas centres
due to lack of awareness of the disease?
Helen Evans - Complication rate of paediatric liver biopsies
at Starship Hospital?
Helen Evans - Study of micronutrient levels and
requirements in paediatric intravenous nutrition (rVN)
27
Gastroenterology (Starship): continued
Helen Evans - Defining the genetic disposition to Biliary
Atresia
Stephen Mouat- Portal hypertensive bleeding in paediatric
patients at Starship Children’s Hospital
Amin Sheikh - Growth & Bone Mineral Density 5 years post
Paediatric Liver Transplant
General Medicine:
Geoff Braatvedt - Diabetic ketoacidosis in Auckland Hospital
in three five-year periods
Robyn North - Statin use in the elderly
Haematology (Adult):
Leanne Berkahn - A Phase 3, Randomised, DoubleBlind, Multicenter study comparing oral MLN9708 plus
Lenalidomide and Dexamethasone versus placebo plus
Lenalidomide and Dexamethasone in adult patients with
relapsed and/or refractory multiple myeloma
Leanne Berkahn - A phase III, randomised, observer-blind,
placebo-controlled, multicentre, clinical trial to assess the
prophylactic efficacy, safety, and immunogenicity of GSK
Biologicals’ herpes zoster gE/AS01B
Leanne Berkahn - A Phase 3 Study of IPI-145 versus
Ofatumumab in Patients with Relapsed or Refractory
Chronic Lymphocytic Leukemia/Small Lymphocytic
Lymphoma
Leanne Berkahn - A Study of IPI-145 and Ofatumumab
in Patients with Chronic Lymphocytic Leukemia/Small
Lymphocytic Leukemia previously enrolled in Study IPI 14507
Peter Browett- A Phase 3, Randomized, Two-Arm,
Open-Label, Multicenter, International Trial of Alisertib
(MLN8237) or Investigator’s Choice (Selected Single Agent)
in Patients With Relapsed or Refractory Peripheral T-Cell
Lymphoma
28
Peter Browett - A Randomized, Double-Blind, Multicenter
Study of Denosumab Compared with Zoledronic Acid
(Zometa) in the Treatment of Bone Disease in Subjects with
Newly Diagnosed Multiple Myeloma
Richard Doocey- A Randomized, Open-label, Phase 3
Study of Carfilzomib Plus Dexamethasone vs. Bortezomib
Plus Dexamethasone in Patients with Relapsed Multiple
Myeloma (The ENDEAVOUR trial)
Timothy Hawkins - A Randomized, Multicenter, Open-label,
Phase 3 Study of the Bruton’s Tyrosine Kinase Inhibitor
PCI-32765 versus Chlorambucil in Patients 65 Years or Older
with Treatmentnaive Chronic Lymphocytic Leukemia or
Small Lymphocytic Lymphoma
Timothy Hawkins - An Open-label Extension Study in
Patients 65 Years or Older with Chronic Lymphocytic
Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who
Participated in Study PCYC-1115-CA (PCI-32765 versus
Chlorambucil)
Paul Ockelford - Reduced-dosed rivaroxaban and standarddosed rivaroxaban versus ASA in the long-term prevention
of recurrent symptomatic venous thromboembolism in
patients with symptomatic deep-vein thrombosis and/or
pulmonary embolism
Nigel Patton - A Phase 3 Study to Evaluate the Efficacy
and Safety of Dinaciclib or Ofatumumab in Subjects with
Refractory Chronic Lymphocytic Leukaemia.
Nigel Patton- An Open-label, Single arm, Multicenter Phase
2 Study of the Bruton’s Tyrosine Kinase Inhibitor PCI-32765
(Ibrutinib) in Patients with Relapsed or Refractory Chronic
Lymphocytic Leukemia or Small Lymphocytic Lymphoma
with 17p Deletion
Nigel Patton - A Phase III Randomized, Placebo-controlled
Clinical Trial to Evaluate the Safety and Efficacy of MK-8228
(Letermovir) for the Prevention of Clinically Significant
Human Cytomegalovirus (CMV) Infection in Adult, CMVSeropositive Allogeneic Hematopoietic Stem Cell Transplant
Recipients
Lucy Pemberton - A Programme of Development for
Older Patients with Acute Myloid Leukaemia or High Risk
Myelodyplastic Sydrome (AML LI)
Lucy Pemberton- A Phase 3 Randomized, Open-Label Study
of Ponatinib versus Imatinib in Adult Patients with Newly
Diagnosed Chronic Myeloid Leukemia in Chronic Phase
Lucy Pemberton - Audit of outcomes in patients with
monosomal karyotype AML
Joanne Scott - Amyloid Mass Spectometry – a case series
based on local experience in New Zealand
Laura Young - Anticoagulant reversal and effects study
(ARES) Collaborative
Laura Young - A Phase III case series clinical study of the
reversal of the anticoagulant effects of dabigatran by
intravenous administration of 5g idarucizumab (BI 655075)
in patients treated with dabigatran etexilate who have
uncontrolled bleeding or require emergency surgery or
procedures
Laura Young - Cancer screening and the incidence of cancer
diagnoses in spontaneous venous thromboembolism
patients at Auckland City Hospital
Haematology/ Oncology
(Starship):
Stephen Laughton - COG ACNS0821: Temozolomide
with Irinotecan versus Temozolomide, Irinotecan plus
Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/
Refractory Medulloblastoma/CNS PNET (Primitive
Neuro-Ectodermal Tumour) of Childhood, A COG Rand.PII
Screening Trial
Stephen Laughton - Children’s Oncology Group (COG)
ACNS0831: Phase III Randomised Trial of Post-Radiation
Chemotherapy in Patients with Newly Diagnosed
Ependymoma Ages 1 to 21 years
Stephen Laughton - COG ACNS1022: A Phase II Randomised
Trial of Lenalidomide in Paediatric Patients with Recurrent,
Refractory or Progressive Juvenile Pilocytic Astrocytomas
and Optic Pathway Gliomas
Stephen Laughton- Australian Children’s Clinical Trials
Study Number ACCT007. Phase I study of vinorelbine,
cyclophosphamide and Rapamycin for recurrent
malignancies in children
Stephen Laughton - CPT-SIOP-2009: Intercontinental
Multidisciplinary Registry and Treatment Optimisation
Study for Patients with Choroid Plexus Tumours
Stephen Laughton - Neuropsychological, Social, Emotional,
and Behavioural Outcomes in Children with Cancer.
ALTE07C1
Peter Bradbeer - International Collaborative Treatment
Protocol For Infants Under One Year With Acute
Lymphoblastic Or Biphenotypic Leukemia (Interfant06)
Stephen Laughton - ACNS0822 A Randomized Phase II/
III Study of Vorinostat (IND#71976) and Local Irradiation
OR Temozolomide and Local Irradiation OR Bevacizumab
(IND#7921) and Local Irradiation
Nyree Cole - Therapeutic infusion of most closely HLAmatched third party donor-derived virus-specific cytotoxic
T-lymphocytes in patients with active viral reactivation postallogeneic stem cell transplantation (R3ACT)
Rachel Longwell - An evaluation of the New Zealand
National Bone Marrow Registry- the differential
probabilities of different ethnicities in finding a suitably
matched, unrelated haemopoietic stem cell donor
Mandy de Silva - Ototoxicity as a Predictor of Outcome in
Osteosarcoma Patients treated with Cisplatin
Scott Macfarlane- COG:AALL06N1 – A study of
Neurocognitive Function in Children Treated for ALL.
A Group-wide, Non-Therapeutic Companion Study to
AALL0232 and AALL0434
Chow Yee Lai - High dose chemotherapy, with autologous
stem cell support/transplant related morbidity and
mortality for patients with Medulloblastoma/Supratentorial
PNET (Primitive Neuroectodermal Tumour) treated on the
SJMP-96
Scott Macfarlane- International Collaborative Treatment
Protocol for Children and Adolescents with Langerhans Cell
Histiocytosis
29
Haematology/ Oncology
(Starship): continued
Scott Macfarlane - Cost benefit analysis of the use
of routine serological titres in reducing the burden
of re-immunisation in chiildren who have undergone
chemotherapy for childhood cancer
Mark Winstanley- Pilot Study Using Myeloablative
Busulfan/Melphalan (BuMel) Consolidation Following
Induction Chemotherapy for Patients with Newly Diagnosed
High-Risk Neuroblastoma
Jane Skeen- Children’s Oncology Group (COG) AREN0534:
Treatment for Patients with Bilateral, Multicentric, or
Bilaterally-Predisposed Unilateral Wilms Tumour
Mark Winstanley - Children’s Oncology Group AEWS1031 A
Phase III Randomized Trial of Adding Vincristine-TopotecanCyclophosphamide to Standard Chemotherapy in Initial
Treatment of Non-metastatic Ewing Sarcoma
Jane Skeen – Our child has died – hear our story
Michael Sullivan- Adolescent and Young Adult Cancer
Services – A Patient Experience Evaluation of Those Aged
12-24 Years Enrolled With AYA Key Workers Between 1st
January and 31st December 2011
Lochie Teague - AALL1131: A Phase III Randomized
Trial for Newly Diagnosed High Risk B-precursor Acute
Lymphoblastic Leukaemia (ALL) Testing Clofarabine (IND#
73789, NSC# 606869) in the Very High Risk Stratum
Lochie Teague - COG ASCT1221: A Randomized Phase II
Study Comparing Two Different Conditioning Regimens
Prior to Allogenic Hematopoietic Cell Transplantation (HCT)
for Children with Juvenile Myelomonocytic Leukemia
(JMML)
Lochie Teague - Phase 2 Trial of Response-Based Radiation
Therapy for Patients with Localised Central Nervous System
Germ Cell Tumours (CNS GCT)
Mark Winstanley- COG ARST0921: A Randomized Phase II
Trial of Bevacizumab (IND# 7921, Avastin) and Temsirolimus
(IND# 61010, Torisel) in Combination with Intravenous
Vinorelbine and Cyclophosphamide in Patients with
Recurrent/Refractory Rhabdomyosarcoma
Mark Winstanley - COG ANBL1221: A Phase II Randomised
Trial of Irinotecan/ Temozolamide with Temsirolimus (NSC#
683864, IND# 61010) or Chimeric Antibody Ch 14.18 (NSC#
623408, IND# 4308) in Children with Refractory, Relapsed
or Progressive Neuroblastoma
Mark Winstanley - New Zealand Adolescent and Young
Adult Cancer Incidence and Survival 2000-2009
30
Mark Winstanley - AEPI10N5: Genetic Epidemiology of
Ewing Sarcoma (Project GenESis)
He Kamaka Waiora:
Bridget Robson - Unequal treatment- the role of Health
Services (part II. Ischaemic Heart Disease & Maternity).
Helen Wihongi - Trialling a National Māori review form at
the Auckland, Waitematā, and Wellington DHBs
Immunology-Clinical:
Rohan Ameratunga - Evaluation of Tim-3 as a cellular
marker in Immunodeficient patients
Immunology-Starship:
Annaliesse Blincoe - Do Defects in the Innate Immune
System Contribute to Non-Cystic Fibrosis Bronchiectasis in
Maori and Pacific Island Children?
Infectious Diseases (Adult):
Simon Briggs: Improving unnecessary intravascular-line
removal on General Medical Wards at Auckland City
Hospital
Simon Briggs - Potential earlier diagnosis of HIV infection if
the routine offer of HIV testing was introduced at ADHB
Rebekah Lane - The Auckland Typhoid Experience: A
retrospective review of cases of enteric fever from 20052010 at the three district health boards in Auckland City
Rebekah Lane - Baseline audit of cefuroxime and
metronidazole use in four departments at Auckland City
Hospital- General Surgery, Urology, Gastroenterology and
General Medicine
Ivone Leong - Targeted and whole exome sequencing to
identify the genetic causes of long QT syndrome
Christopher Luey - The impact of loading doses and a
vancomycin calculator on target vancomycin trough
concentration achievement at two Auckland hospitals: a
prospective study
Arthur Morris- Candida albicans hypermutable genes.
Basic biology and potential use in risk stratification for
candidemia patients
Susan Mundt - Experiences of HIV stigma and
discrimination in the healthcare settings
Mitzi Nisbet - Audit of screening and treatment for Latent
Tuberculosis Infection in patients with HIV infection,
Mitzi Nisbet - How many induced sputum samples are
required to diagnose smear negative TB
Keith Petrie- The SMART Study: Can a Smartphone
application improve adherence to antiretroviral therapy?
Stephen Ritchie - Understanding nasal flora and prevention
of Staphylococcus aureus disease
Stephen Ritchie - Use of hospital inpatient services by
people living with HIV/AIDS
Infectious Diseases (Starship):
Michael Baker - New Zealand Rheumatic Fever Risk Factors
Study
Rachel Webb - Familial study of Rheumatic Fever using
Echocardiography and Gene Expression Profiling
LabPlus (Genetics, Immunology,
Microbiology, Virology):
Mary De Almeida - Investigation of a cluster of hospitalacquired invasive pneumococcal disease cases at Auckland
City Hospital
Donald Love - Cardiac inherited disease registries
Arthur Morris- Susceptability of bloodstream Candida
species to Echinocandins
Sally Roberts - Is Clostridium difficile PCR-ribotype NZ11/21
more likely to be associated with severe community-onset
disease than other PCR-ribotypes in the Auckland setting?
Sally Roberts - Genetic analysis of emerging ceftriaxone
resistance among isolates of gonorrhoea
Sally Roberts - Global Antimicrobial Susceptability
Surveillance Program
Sally Roberts - Study for Monitoring Anti-Microbial
Resistance Trends
Sally Roberts - Assessing the role of echocardiography in
patients with Staphylococcus aureus bacteraemia
Clinton Turner - Review of MGMT promoter methylation
analysis at ADHB
Deborah Williamson- A prospective observational casecontrol study of the clinical and molecular epidemiology
of skin and soft tissue infections in paediatric patients
presenting to Starship Children’s Hospital Auckland, New
Zealand.
Deborah Williamson - Population-based assessment of
the epidemiology and outcomes of Staphylococcus aureus
infections at the Auckland District Health Board, 2001-2011
Deborah Williamson - Validity of hospital discharge coding
in diagnosing microbiologically confirmed Staphulococcus
aureus infections
Fintan Garavan - Clozapine-Associated Myocarditis and
Cardiomyopathy: Investigating a Metabolic Basis of Toxicity
31
Liver Transplant Unit:
William Abbott - Search for therapeutic targets that initiate
HBeAg seroconversion and decrease the risk for liver cancer
in chronic hepatitis B
William Abbott- Prediction of chronic hepatitis B by
sequencing the S open reading frame
Ed Gane - A Phase 3, Safety and Efficacy Study of
Boceprevir/Peginterferon Alfa-2a/ribavirin in Chronic HCV
Genotype 1 IL28B CC Subjects
Ed Gane - An Open-Label Study to Explore the Clinical
Efficacy of GS 7977 with Ribavirin Administered PreTransplant in Preventing Hepatitis C Virus (HCV) Recurrence
Post-Transplant
Ed Gane - GS-US-283-0106 A Double-Blind, Randomized,
Placebo-Controlled, Single and Multiple-Dose Ranging,
Adaptive Study Evaluating the Safety, Tolerability,
Pharmacokinetics, Pharmacodynamics, and Antiviral
Activity of GS-9620 in Treatment
Ed Gane - GS-US-283-0102: A Double-Blind, Randomized,
Placebo-Controlled, Single and Multiple-Dose Ranging,
Study Evaluating the Safety, Tolerability, Pharmacokinetics,
Pharmacodynamics, and Antiviral Activity of GS-9620 in
Virologically
Ed Gane- A Phase 3, Randomized, Double-Blind, Controlled
Study Evaluating the Efficacy and Safety of Peginterferon
Lambda-1a, with and without Daclatasvir, Compared to
Peginterferon Alfa-2a, Each in Combination with Ribavirin in
Partial Responders to Peginterferon Alfa and Ribavirin (P/R),
Intolerant or Ineligible to P/R Subjects and Treatment- Naïve
Subjects with Chronic Hepatitis C Genotype 1b Infection
Ed Gane - An Open-Label Re-treatment Study with PegInterferon Alfa-2a, Ribavirin and BMS-790052 With or
Without BMS-650032 for Subjects With Chronic Hepatitis C
Ed Gane - GS-US-334-0109: An Open-Label Study of GS7977 + Ribavirin for 12 Weeks in Subjects with Chronic HCV
Infection (GT 2 or GT3) who Participated in Prior Studies
Evaluating GS-7977
32
Ed Gane - A Phase 2, Multicenter, Open-Label Study to
Investigate the Safety and Efficacy of GS-7977 and Ribavirin
for 24 weeks in Subjects with Recurrent Chronic HCV Post
Liver Transplant
Ed Gane - A Phase 2, Multicenter, Open-Label Randomized
Study to Investigate the Safety and Efficacy of GS-7977 and
Ribavirin Administered for 24 weeks in Patients Infected
with Chronic HCV with Cirrhosis and Portal Hypertension
with or without
Ed Gane- A Randomized, Double-blind, Placebo-controlled
Study to Evaluate the Efficacy and Safety of ABT-450/
Ritonavir/ ABT 267 (ABT-450/ritonavir/ABT-267) and ABT333 Co administered with Ribavirin (RBV) i
Ed Gane - A Phase 1 Open LabelParallel Group Single
Dose Study to Evaluate the Pharmacokinetics of GS5885 in
Subjects with Normal Hepatic Function and Severe Hepatic
Impairment
Ed Gane- BV28333- An exploratory evaluation of interleukin
28B (IL28B) genotype, protein and RNA biomarkers in
serum samples (stored, already obtained from completed
studies) from subjects with HBe-antig
Ed Gane - A Phase 4, blood sample collection study
for exploratory evaluation of the association of single
nucleotide polymorphisms with treatment responses from
subjects
Ed Gane - A Phase III, Randomised, Double-Blind Study of
Tivantinib (ARQ197) in Subjects with Met Diagnostic-High
Inoperable Hepatocellular Carcinoma (HCC) Treated with
One Prior Systemic Therapy
Ed Gane - A Phase II trial of Refametinib as first or second
line treatment in patients with RAS mutant unresectable
advanced or metastatic Hepatocellular Carcinoma (HCC)
Ed Gane - A Follow-up Study to Assess Resistance and
Durability of Response to AbbVie Direct-Acting Antiviral
Agent (DAA) Therapy in Subjects Who Participated in
Phase 2 or 3 Clinical Studies for the Treatment of Chronic
Hepatitis C Virus (HCV) Infection
Ed Gane - Molecular predictors of response to sorafenib
as adjuvant therapy after resection in hepatocellular
carcinoma. Tissue biomarker study of the STORM
randomized trial (BIO-STORM)
Management:
Ed Gane - A Phase 3, Multicenter, Open-Label Study to
Investigate the Efficacy and Safety of Sofosbuvir/Ledipasvir
Fixed-Dose Combination for 12 Weeks in Subjects with
Chronic Genotype 1 or 4 Hepatitis C Virus (HCV)
Dora Bocirnea - Investigating Patient Satisfaction with
Complaint Resolution
Ed Gane - An Open-Label, Multicenter Study To Evaluate
The Efficacy And Safety Of Sofosbuvir/Ledipasvir Fixed-Dose
Combination ± Ribavirin For 12 or 24 Weeks In Chronic
Genotype 1 HCV Infected Participants Who Participated
Ed Gane - A prospective, single-arm, multicenter,
uncontrolled, open-label Phase II trial of refametinib
(BAY 86-9766) in combination with sorafenib as first line
treatment in patients with RAS mutant Hepatocellular
Carcinoma (HCC)
Ed Gane - Directly acting antiviral (DAA) based therapy for
recently acquired hepatitis C II
Ed Gane - A Phase IIBIII, openlabel, randomized,
comparative study to assess the efficacy of ABX203 to
maintain control of Hepatitis B disease after cessation
of treatment with nucleos(t)ide analogs in adult HBeAg
negative patients with chronic Hepatitis B in the Asia Pacific
region
Rachael Harry- Improving the long term outcome of
paediatric liver transplant recipients in New Zealand:
Identifying risks and protective factors for outcomes in
adolescence and early adulthood
Peter Beaver - The effects of organisation and
governanance on patient safety in NZ public hospitals
Deidre Maxwell - Understanding governance arrangements
concerning public health sector clinical networks in New
Zealand
Paul Rouse- Developing a multi-stakeholder performance
measurement framework for health services contracting
Mental Health (Adult):
Nadav Avny - Mindfulness based stress reduction (MBSR)
for ADHB staff
Jane Casey - Clinical utility of some commonly used
cognitive screening tools in New Zealand
Liesje Donkin - Parental experience of Maudsley Family
Based Treatment (MFBT)
Emme Chacko - Metabolic Side Effects of Atypical
Antipsychotics in Older Adults
Gary Cheung - Assessing Capacity to Engage in Advance
Care Planning in Older People
Gary Cheung - Late Life Suicide Attempt Study
Gary Cheung - Routine assessment of depressive symptoms
in older people- the New Zealand experience with interRAI
Brett Knock- Investigation of Psychological, Physiological
and Psychosocial Problems in Hepatitis C Patients Following
Pegylated Interferon Alpha Pls Ribavirin Treatment
Gary Cheung - Validity of the InterRAI outcome scales for
older adults in specialist mental health services
Alex Lampen-Smith- Future care preferences in patients
with advanced liver cirrhosis
Mark Franks - The clinical utility of a cognitive behavioural
psychological forumlation in the treatment of depression
and anxiety: a Pasifika case example
Chris Moyes - Audit of AFP screening for detection of
Hepatocellular Carcinoma in carriers of Hepatitis B Virus
Alison McKinlay - How do older adults cope with a
diagnosis of mild cognitive impairment?
33
Mental Health Adult: continued
Sione Maka - A qualitative survey on the impacts of Lotofale
Pacific Island Mental Health Services' group on clients: a
Pacific Island social work perspective
Anthony O’Brien - Use of restrictive measures in inpatient
mental health services
Hiran Thabrew - Game for Health: Development of a
modular eHealth resource for children and adolescents
with chronic illness
Chandni Prakash - Review of mood stabiliser and
antipsychotic use in Maternal Mental Health Service users
in pregnancy and postpartum and outcome
Tania Windelborn - Examination of the utility of a self help
computerised cognitive behavioural programme (SPARX) in
an acute adolescent in-patient unit
Kate Prebble - A history of the establishment of forensic
psychiatric services in the Auckland region: An exploration
of archival evidence
National Women’s Health –
Jemaima Tiatia - Suicidal Behaviours and Ideation Amongst
Samoan People: The Journey Towards Prevention
Fertility Plus, Gynaecological Oncology,
High Risk Maternity, Midwifery,
Obstetrics and Gynaecology:
Malcolm Tingle - Clozapine-associated myocarditis and
cardiomyopathy: investigating a metabolic basis of toxicity
Tony Baird - The drinking habits of women during
pregnancy
Jane Walton - An Efficacy and Safety Trial of MK-8931 in
subjects with amnestic Mild Cognitive Impairment due to
Alzheimer’s Disease (Prodromal AD)
Philip Baker - Environmental factors that are likely to
influence pregnancy – in particular fetal growth restriction
Sara Weeks - F1D-MC-B034(a) Post-Injection Syndrome in
Patients with Schizophrenia Receiving Olanzapine LongActing Injection
Richard Worrall - Understanding patients’ experiences of
Fraser McDonald Unit and the impact of these on its design
Mental Health (Starship):
Caleb Armstrong - Review of demographics and other
characteristics of youths undergoing court ordered
assessment by the Regional Youth Forensic Service over a
12 month period
Maneesh Deva – Clinical audit of inpatient eating disorders
service Starship Children’s Hospital 2005- 2012
Peter Dowrick- Video self modelling in food selectivity
Kerry Gibson - Young People’s narrative accounts of their
experiences of psychological assessment and counselling
34
Josephine Stanton - Referrers’ perspectives of engaging
with the Child and Family Unit
Johanna Bannister- Do interventions have a positive impact
on women who disclose partner violence in a health-care
setting?
Larry Chamley- Understanding the placenta: the life cycle of
placental trophoblasts in health and diseases of pregnancy
Catherine Cook- Cervical smears and other gynaecological
examinations: The perceptions of women and health
professionals
Catherine Cook - Perceptions of women about factors that
account for delays from initial symptoms of endometrial
cancer to specialist referral
Lisa Dawes - A Blinded Prospective Observational Study
Comparing Qualitative fFN, Quantitative fFN and PartoSure
(PAMG-‐1) to assess the Risk of Preterm Birth in Women
with Threatened Preterm Labour
Natalie Desmond - Maternal general practice enrolment
data-match audit to improve the newborn continuum of
care
Isabelle Eadie - Midwifery practice in an Obstetric High
dependency Unit in New Zealand
Lois Eva - PRINCess- The Conservative Management of
Cervical Intraepithelial Neoplasia (CIN2) in Young Women
to Age 25
Cindy Farquhar - Fertility Urinary Monitoring Study:
Assessment of urine metabolites to identify hormonal
responses.
Cindy Farquhar – The intraUterine Insemination (TUI) study
Sarah Fitzgibbon- Management of abnormal uterine
bleeding at Auckland District Health Board
Premjit Gill - An Evaluation of Body Mass Index and
Ethnicity and Endometrial Hyperplasia/Cancer in
Premenopausal Women with Abnormal Uterine Bleeding
Elizabeth Glanville- Management of women following
excision of vulval intraepithelia neoplasia
Katie Groom- MAgnesium Sulphate At 30 To 34 Weeks’
GEstational Age: Neuroprotection TriAl
Katie Groom- STRIDER: A Randomized Controlled Trial
of Sildenafil Therapy in Dismal Prognosis Early-Onset
Intrauterine Growth Restriction (New Zealand and Australia
Katie Groom- The Fetal OXygenation Study. Free fetal RNA
in the maternal circulation: a biomarker of intrauterine
hypoxia in growth-restricted fetuses. (FOX Study)
Katie Groom - The WISH Project Follow Up Study
Devashana Gupta - Endometrial injury in women with
subfertility undergoing IVF/ICSI or expectant management;
the Pipelle Injury in Pregnancy (PIP) studies
Fiona Keogh- HE 4 as a tumour marker for the prediction of
ovarian carcinoma
Logeswary Kumarasamy - Patient satisfaction with Jadelle
Contraceptive Implant: The National Women's Hospital
Experience
Bev Lawton - Assessing potentially preventable severe
acute maternal morbidity: Extension from 4 DHBs to a
National SAMM review
Emma McGoldrick - Identifying the barriers and enablers
in the implementation of the New Zealand and Australian
Antenatal Corticosteroid Clinical Practice Guideline. A
randomised controlled trial protocol
Claire McLintock- A national population-based study of
rheumatic heart disease in pregnancy
Ed Mitchell- Ed Mitchell- Maternal Sleep in Pregnancy
Ellie Moon- Evaluation of the safety of New Zealand’s
maternity system: the relationship between maternity care
provider and fetal and neonatal outcomes
Helen Roberts- Follow up of midwife Jadelle insertions
Helen Roberts - Bleeding patterns and nonmenstrual
adverse event rate following immediate insertion post
abortion of the contraceptive implant Jadelle and the effect
on continuation rates at one year
Janet Rowan- Metformin in Gestational Diabetes: The
Offspring Follow Up at 7-9 years
Suzanne Stevens - Prenatal Alcohol Exposure, Genetic
Interplay and Neurobehavioural Development (Pilot Study)
Peter Stone - A novel method for non-invasive antenatal
diagnosis by harvesting trophoblasts
Peter Stone - An investigation of the effect of
antihypertensives on endothelial activation in preeclampsia
Victoria Taylor - Pregnancy associated Plasma Protein
(Papp-A) and Association with Small for Gestational Age
(SGA) and Intrauterine Fetal Demise (IUFD)-Does the
overseas story apply in NZ?
Michelle Wise- The BEC Study: An evaluation of body mass
index and ethnicity and endometrial hyperplasia/cancer in
premenopausal women with abnormal uterine bleeding.
35
National Women’s Health: continued
Michelle Wise- Satisfaction with birth experience and with
antenatal consultation about previous caesarian
Jennifer Pereira - A national incidence study of Multiple
Sclerosis (MS) in New Zealand
Michelle Wise - Womens’ preference for subsequent births
after a primary Casearean Section: An early post-natal
review of attitudes
Richard Roxburgh - Factors influencing patient experience
in diagnosis of genetic disease – a retrospective study
investigating the experience Huntingtons disease and
Myotonic Dystrophy patients had at the time they were first
informed of their genetic diagnosis
Neurology (Adult):
Alan Barber - EXTEND-IA: Extending the time for
thrombolysis in emergency neurological deficits- intraarterial
Richard Roxburgh - Cross section of personality traits in at
risk, gene positive and clinically diagnosed patients with
Huntington’s Disease
Alan Barber- Platelet Oriented Inhibition in New TIA &
minor ischaemic stroke (POINT) trial
Richard Roxburgh- A Prospective Registry Study in a Global
Huntington’s Disease Cohort (Enroll-HD)
Peter Bergin - Incidence Study of Status Epilepticus in the
Greater Auckland Region
Richard Roxburgh - Using genome screening tools including
but not limited to whole exome sequencing, whole
genome sequencing, genome-wide copy number variation,
homozygosity mapping
Elizabeth Broadbent- Perceptions about stroke and its
impact on daily living
Wallace Brownlee- Audit of NMO-IgG antibody testing and
cases of neuromyelitis optica in Auckland
Winston Byblow - Falling off the curve: The link between
impulsivity and dopamine
Maurice Curtis- New brain cell production in Huntington’s
diseased brains
Valery Feigin - Epidemiology of atrial fibrillation in
ischaeamic stroke patients: a population based study in
Auckland, New Zealand
Rita Krishnamurthi- Community outcomes after a bleed
(subarachnoid haemorrhage, SAH) in the Brain
Gwyn Lewis- The effects of non-invasive brain stimulation
on pain, corticomotor excitability, and the nociceptive
system in people with neuropathic pain
Julie Luker - Exploring the implementation of early
rehabilitation for patients with acute stroke
Ailsa McGregor - Tolerability of varenicline and feasibility of
touchscreen cognitive testing in patients with Huntington’s
disease
36
Richard Roxburgh - Prevalence and impact of inherited
Myopathies in New Zealand
Mark Simpson- Clinical usefulness of the Fog Test for the
diagnosis of dystonia
Barry Snow - A Randomised, Double-blind, Multi-centre,
Phase II, Dose Parallel Study to Determine the Safety and
Efficacy of MT10109 (Clostridium Botulinum Toxin Type A)
in Subjects with Cervical Dystonia in Comparison to BOTOX®
Barry Snow - A Phase I/IIa, Open-label Investigation of the
Safety and Clinical Effects of NTCELL [Immunoprotected
(Alginate-Encapsulated) Porcine Choroid Plexus Cells for
Xenotransplantation] in Patients with Parkinson’s Disease”
Protocol Number LCT/PD-012
Barry Snow - A Phase I/IIa, Open-label Investigation of the
Safety and Clinical Effects of NTCELL [Immunoprotected
(Alginate-Encapsulated) Porcine Choroid Plexus Cells for
Xenotransplantation] in Patients with Parkinson’s Disease”
Protocol Number LCT/PD-012
Cathy Stinear - Accelerating recovery after stroke with
neuromodulation: a feasibility study
Elizabeth Walker- A Randomized, Double-Blind, PlaceboControlled Study of the Safety and Efficacy of Intranasal
Midazolam in the Outpatient Treatment of Subjects with
Seizure Clusters
Elizabeth Walker - An Open-Label Safety Study of USL261 in
the Outpatient Treatment of Subjects with Seizure Clusters
Ernest Willoughby - Phase Iib randomised, double-blind,
placebo-controlled, dose ranging trial of Vitamin D3 in
patients with a first demyelinating event
Ernest Willoughby - A dose-frequency blinded, multicenter,
extension study to determine the long-term safety and
efficacy of PEGylated Interferon Beta-1a (BIIB017) in
subjects with relapsing multiple sclerosis
Ernest Willoughby - A Double-masked, Placebo-controlled
Study with Open label Period to Evaluate the Efficacy and
Safety of MEDI-551 in Adult Subjects with Neuromyelitis
Optica and Neuromyelitis Optica Spectrum Disorders
Neurology (Starship):
Hannah Jones - Advances in the understanding of
autoimmune encephalitides and associated movement
disorders in children
Cynthia Sharpe - Efficacy of intravenous levetiracetam in
the treatment of neonatal seizures, a phase 2 randomised,
blinded, controlled treatment trial
Neurosurgery:
Abhinav Jain - Outcomes of the combined medical and
surgical management of Gliosarcoma: 1993-2013
Kathryn Quick - A review of trachesotomy insertion in
moderate to severe traumatic brain injury patients at
ADHB, including analysis ofthe clinical implications and a
comparison to best practice guidelines
Newborn:
Jane Alsweiler - Immunisation of extremely preterm babies
after discharge from the neonatal intensive care unit
Jane Alsweiler- Investigating the effects of probiotics on the
neurodevelopmental outcomes of preterm infants
Jane Alsweiler - Hyperglycaemia and Insulin in Neonates
Trial
Jane Alsweiler - EYE-SPY, Examining young eyes for signs of
prematurity
Jane Alsweiler - The use of point of care testing for the
measurement of blood glucose concentrations in babies
at-risk of neonatal hypoglycaemia
Jane Alsweiler - Magnesium for Neuroprotection:
Understanding Mechanisms
Frank Bloomfield - Does bias gas flow in ventilated preterm
babies affect lung injury or the risk of BPD? (the FLORA
study)
Frank Bloomfield - Multinational survey of nutritional
practices in very low birthweight babies (NeoNutriNet
Marian Buksh - Multicentre randomised controlled trial of
minimally invasive surfactant therapy in preterm infants 2528 weeks gestation on continuous positive airway pressure
Cath Conlon- Post discharge nutrition of preterm babies:
micronutrient status & feeding practices of preterm babies
after hospital discharge
Barbara Cormack- PROVIDE: The impact of Protein
Intravenous Nutrition on Development in preterm babies.
A randomised controlled trial of more intravenous protein
in the first week of life
Jo Hegarty- A dosing trial to determine the most effective
dose and frequency of prophylactic oral dextrose gel in
preventing neonatal hypoglycaemia
Chuan-Chuan Lan - Follow up management of babies born
to hepatitis B positive mothers
Wingchi Leung - Current practice of red blood cell
transfusion in the neonatal intensive care unit
Ed Mitchell - A maternal probiotic intervention for infant
allergic disease prevention
37
Newborn: continued
Keith Petrie- Can a brief information session reduce the
stress levels of mothers of newborns admitted to a high
dependency unit?
Janine Rouse- Improving patient flow from the Department
of Critical Care at Auckland City Hospital to general medical
and surgical wards
Keith Petrie - Evaluating the psychometric properties of two
measures of neonatal pain
Older People’s Health:
Saul Snowise- The utility of reticulocyte haemoglobin to
assess iron availability and anaemia in paediatric dialysis
patients
Anna Tottman- Long-term neurodevelopmental
consequences of neonatal hyperglycaemia and its
treatment with insulin
Northern Regional
Genetics Service:
Pauline Elmer-English - An ethnography of children
diagnosed with medium-chain acyl-CoA dehydrogenase
deficiency (MCADD)
Emma Glamuzina - A Long-Term Study for Extended BMN
701Treatment of Patients with Pompe Disease who have
Participated in a BMN 701 Study
Callum Wilson - Natural history of elevated newborn
screening C14.1 in New Zealand
Nursing:
Jill Clendon - Barriers and facilitators to implementing
flexible working hours and career planning for older nurses
in the workplace
Megan Connolly - Clinical Leadership of Registered Nurses
at the point of care in the Emergency Department
Annette Dickinson - Medication management in newly
graduated nurses: a comparative study between New
Zealand and Sweden
Meryn Gott - Adapting the views of informal carers
(‘VOICES’) questionnaire to the New Zealand context
Romana Raby - Nurses’ perceptions of their clinical
leadership behaviours at the point of care
38
Geoff Braatvedt - Epidemiology of fragility fracture at
Auckland Hospital
Roger Harris - Australian and New Zealand Hip Fracture
Registry (ANZHFR)
Oncology (Adult):
Karen Amies - A multicenter, randomized, double-blind,
placebo-controlled phase III trial of tecemotide versus
placebo in subjects with completed concurrent chemoradiotherapy for unresectable stage III non-small cell lung
cancer (NSCLC)
Reuben Broom - Dovitinib In 1st-Line Renal Cell Carcinoma,
an Investigation into tumour GENe status and Correlation
with Efficacy – 1st exploratory study (Diligence-1)
Kathryn Chrystal - Retrospective clinical audit
investigating the pre-medication regimen used before
the drug carboplatin and cisplatin infusions while on a
hypersensitivity regimen if gynaecological cancer
Kathryn Chrystal- An international phase III randomised
trial of dose-fractionated chemotherapy compared to
standard three-weekly chemotherapy, following immediate
primary surgery or as part of delayed primary surgery, for
women with newly diagnosed epithelial ovarian cancer
Kathryn Chrystal - A Randomized, Open Label Study
Comparing the Combination of YONDELIS® and DOXIL®/
CAELYX® With DOXIL®/CAELYX® Monotherapy for
theTreatment of Advanced Relapsed Epithelial Ovarian,
Primary Peritoneal, or Fallopian Tube Cancer
Dragan Damjanovic- A randomized, open-label, multicenter
Phase IIIb study comparing two trastuzumab dosing
regimens, each in combination with cisplatin / capecitabine
chemotherapy, as first-line therapy in patients with HER2positive
Miriama Delaibatiki - Can IMRT reduce the dose to
mandible and hence osteoradionecrosis?
Geeta Gala - Faster Cancer Treatment: Pilot of computed
tomography colooscopy scanning in the Northern Region
Michael Findlay- An internal examination of colorectal
cancer management in New Zealand (the PIPER Project)
Fritha Hanning - A randomised phase 3 trial of accelerated
versus standard BEP chemotherapy for patients with
intermediate and poor-risk metastatic germ cell tumours
ANZUP, Protocol number: ANZUP 1302
Michael Findlay - A Phase II, Multicentre, Open-Label,
Randomized Study Evaluating The Efficacy And Safety of
Folfiri + MEDHD7945A Versus Folfiri + Cetuximab In Second
Line In Patients With KRAS Wild-Type Metastatic Colorectal
Cancer
Michael Findlay - Assessment of Overall Survival of
FOLFOX6m plus SIR-Spheres microspheres versus
FOLFOX6m alone as first line treatment in patients with
non-resectable liver metastases from primary colorectal
carcinoma in a randomised clinical Study
Peter Fong - Phase II single arm, non-randomised, multicentre study to evaluate the efficacy of oral TKI258 as
second line therapy in patients with either FGFR2 mutated
or wild-type advanced and/or metastatic endometrial
cancer (TKI Endo)
Peter Fong - A Phase I Study to Evaluate the Safety,
Tolerability and Efficacy of SCH900353 in Subjects with
Advanced Solid Tumours. Protocol No: PO66203
Peter Fong- A Study in Japan and Ex-Japan to Characterize
the Pharmacokinetic and Pharmacodynamic Response to
Orteronel (TAK-700) in Chemotherapy-Naïve Patients with
Castration-Resistant Prostate Cancer
Peter Fong- Genetic analysis of ovarian granulosa cell
tumours (GCT)
Peter Fong - A Multinational, Phase 3, Randomized,
Double-Blind, Placebo-Controlled, Efficacy and Safety Study
of Enzalutamide in Patients with Nonmetastatic CastrationResistant Prostate Cancer
Peter Fong - A Multicenter, Randomized, Double-Blind,
Placebo-Controlled Phase 3 Study of Rucaparib as Switch
Maintenance Following Platinum-Based Chemotherapy
in Patients with Platinum-Sensitive, High-Grade Serous
or Endometrioid Epithelial Ovarian, Primary Peritoneal or
Fallopian Tube Cancer
Fritha Hanning - A Phase III Randomized Clinical Trial of
Pembrolizumab (MK-3475) versus Paclitaxel, Docetaxel
or Vinflunine in Subjects with Recurrent or Progressive
Metastatic Urothelial Cancer
Nuala Helsby- Observational study of frequency and causes
of impaired liver metabolism of cyclophosphamide in breast
cancer (LIME)
Chakiath Jose - A randomised phase 3 trial of enzalutamide
in androgen deprivation therapy with radiation therapy for
high risk, clinically localised, prostate cancer
Han Kim- Patterns of failure in Oropharyngeal carcinoma
and whether ipsilateral radiotherapy for lateralised HPV+
tonsillar carcinoma is a viable option of de-scalation
George Laking- SCOT – Short Course Oncology Therapy. A
study of adjuvant chemotherapy in colorectal cancer
Ben Lawrence- Describing the incidence, management and
outcomes for patients with Neuroendocrine Tumours in
New Zealand (NET Epidemiology)
Ben Lawrence- Genomic analyses of neuroendocrine
tumour (NET) samples for the development of improved
clinical predictors and prognosticators
Ben Lawrence - A Randomized, Double-Blind, Phase 3
Study of the JAK1/2 Inhibitor, Ruxolitinib or Placebo in
Combination With Capecitabine in Subjects With Advanced
or Metastatic Adenocarcinoma of the Pancreas Who Have
Failed or Are Intolerant to First-Line Chemotherapy
Ben Lawrence - Generation of patient derived xenografts
Dongxu Liu - Artemin as a diagnostic/prognostic biomarker
for breast cancer (the ARTN biomarker study)
39
Oncology (Adult): continued
Andrew Macann- A Randomized Trial Of Weekly Cetuximab
And Radiation Versus Weekly Cisplatin And Radiation In
Good Prognosis Locoregionally Advanced HPV-Associated
Oropharyngeal Squamous Cell Cancer (OPSCC)
Michael McCrystal - GO28141: A phase III double
blind placebo controlled study of vemurafenib versus
vemurafenib plus GDC-0973 in previously untreated
BRAF-V600 mutation positive patients with unresectable
locally advanced or metastatic melanoma.
Michael McCrystal - Real-World Chart Review Study
of Survival Outcomes in Patients with Melanoma who
Received Dabrafenib for unresectable (Stage IIIc) and
metastatic (stage IV) melanoma as part of the Named
Patient Programme (NPP) (compassionate use of
Dabrafenib)
Mark McKeage- A Phase I/II, Multi-Centre, Open-Label,
Dose Escalation Trial of the Safety and Pharmacokinetics
of Intravenous PR610 Given Weekly in Subjects with Solid
Tumours (Proacta)
Mark McKeage- Oncogenic Mutations in Cancer Patients
Detected by Sequenom Genotyping: A Prospective
Feasibility Clinical Study (ONCOMING study).
Mark McKeage- A Phase II, multicentre, single-arm study
of oral LDK378 in Crizotinib naive adult patients with ALKactivated Non-small cell lung cancer
Mark McKeage- A Phase I, open-label, multicentre,
3-period, fixed-sequence study to investigate the effect of
Vemurafenib on the pharmacokinetics of a single dose of
acenocomarol in patients with BRAFV600 mutation-positive
metastatic malignancy
Mark McKeage- A Phase IV, post marketing, open-label,
extension (rollover) study of vemurafenib in patients with
BRAFV600 mutation-positive malignancies previously
enrolled in an antecedent vemurafenib protocol
Mark McKeage- An open-label, multi-center Phase 1
dose-finding study of RAD001 (everolimus,Afinitor) in
combination with BEZ235 in patients with advanced solid
tumours
40
Mark McKeage - A Phase III mutlticentre, randomised
study of oral LDK378 versus standard chemotherapy in
previously untreated adult patients with ALK rearranged
(ALK-positive), stage IIIB or IV, non-squamous non-small cell
lung cancer
Robert McNeill- Northern Region Lung Cancer Patient and
Family/Whanau Evaluation Project
Soizick Mesnage- Retrospective audit of patients with BRAF
mutation positive metastatic melanoma who have received
treatment with dabrafenib
Soizick Mesnage- Retrospective audit of patients with
muscle invasive bladder cancer treated with neoadjuvant
chemotherapy for curative intent
Soizick Mesnage - Mapping gastro-oesophageal cancer in
the Auckland-Northland region
Nicola Mitchell- CEA measurement during adjuvant
chemotherapy for colon cancer; does a transient
abnormaility impact on overall survival?
Nicola Mitchell - Metastatic Renal Cell Cancer: A
Multicenter Prognostic Factors Project in the Era of
Targeted Therapy
David Porter- Clinical audit investigating the changes
of practice from a three day oral dexamethasone premedication regimen to a single dose IV (dexamethasone)
before the chemotherapy drug docetaxel infusion
David Porter - A randomized controlled study of YONDELIS
(Trabectedin) or dacarbazine for the treatment of advanced
liposarcoma or leiomyosarcoma previously treated with an
anthracycline and ifosfamide
Lisa Reynolds - Comparing a brief mindfulness intervention
with standard relaxation therapy on reducing distress
and avoidance behaviour in cancer patients undergoing
chemotherapy
Emily Ryder- A Multi-Centre Observational Study on
the Prevalence of BRAF V600 Mutations in Stage III-IV
Melanoma in New Zealand
Giuseppe Sasso - Retrospective audit of acute genitourinary toxicity in patients with radical radiotherapy
Richard Sullivan - A Randomized, Double-Blind, Phase 3
Study of Docetaxel and Ramucirumab versus Docetaxel
and Placebo in the Treatment of Stage IV Non-Small Cell
Lung Cancer Following Disease Progression after One Prior
Platinum-Based Therapy. Protocol I4T-MC-JVBA© REVEL.
Richard Sullivan - A Phase III, Open-Label, Multicenter,
Randomized Study to Investigate the Efficacy and Safety
of MPDL3280A (Anti-PD-L1 Antibody) Compared With
Docetaxel in Patients With Non-Small Cell Lung Cancer After
Failure with Platinum-Containing Chemotherapy
Richard Sullivan - A Randomized Open-Label Phase III Trial
of MK-3475 versus Platinum based Chemotherapy in 1L
Subjects with PD-L1 Strong Metastatic Non-Small Cell Lung
Cancer
Paul Thompson - A non-interventional translational
research follow-up study to the VELOUR clinical trial
(multicentre international study of aflibercept versus
placebo in combination with FOLFIRI for metastatic
colorectal cancer)
Kirsten van Kessel - Experiences of post-cancer fatigue in
New Zealand: a qualitative study
Ophthalmology:
Riyaz Bhikoo - Primary ocular toxoplasmosis presenting to
tertiary referral services
Harry Bradshaw- Prevalence of rhegmatogenous retinal
detachment (RRD) in patients with myopia in NZ
Jennifer Craig - Evaluating outcomes of severe microbial
keratitis resulting in admission to Auckland Hospital over
the years 2006-2007 and 2013-2014
Shuan Dai - Ten year outcome of laser treatment for
retinopathy of prematurity in tertiary centres in New
Zealand
Paul Donaldson- Identifying targets for the development of
anti-cataract therapies
Akilesh Gokul - Keratoconus- clinical characteristics,
incidence, prevalence and severity amongst the New
Zealand population
Elissa McDonald - Efficacy and safety of topical
corticosteroid compared to placebo in the treatment of
bacterial keratitis
Charles McGhee - Peripheral ulcerative keratitis
and necrotising scleritis in a single centre setting- a
retrospective review
Charles McGhee - Audit of outcomes of cataract surgery in
Auckland
Stuti Misra - Ocular biometric parameters prior to cataract
surgery
Justin Mora- An Epidemiological Investigation of Congenital
Eye Anomalies in New Zealand and Australia
Andrew Old- Review of visual acuity before and after
cataract surgery at Auckland and Waitemata DHBs
Dipika Patel - Biometric and biomechanical properties of
the eye in health and disease
Hussain Patel - The effect of selective laser trabeculoplasty
on the intraoccular pressure diurnal variation as measured
by the drinking water test
Hussain Patel - Demographic analysis of glaucoma in a New
Zealand population
Jo Sims- Spectrum of uveitis in New Zealand
Shuan Dai - Quality Audit of Specialist Nurse Grading of
Retinopathy of Prematurity Photographs
Jo Sims- Tuberculosis-related uveitis in New Zealand
Shuan Dai - Clinical outcome after discharge following ROP
screening in the neonatal unit
Julia Slark - Exploring the patient experience in Oncology
Outpatient. Information, organisation and confidence in
care
41
Ophthamology: continued
David Squirrell - Investigation of Noncompliance for
Diabetic Retinopathy Appointments (INDRA)
Michel Neeff - An investigation into the cause of chronic
suppurative otitis media
Benjamin Thompson- Amblyopia: causes, consequences
and rehabilitation
Lailade Osunsade - Intracranial sepsis and Sigmoid Sinus
Thrombosis
Benjamin Thompson- Evaluation of Glaucoma and
Ischaemic optic neuropathy as Neurodegenerative Diseases
using Structural and Functional Magnetic Resonance
Imaging (a pilot study)
Hester Taekema Landham - Simulation training for new
tracheostomy parents- does it improve self-efficacy and
competence
Benjamin Thompson - A randomised clinical trial of a new
binocular treatment for amblyopiaStructural and Functional
Magnetic Resonance Imaging (a pilot study)
Orthopaedics (Adult):
Simon Thornley - Study of the prevalence of blindness and
low vision in New Zealand using the capture recapture
method
Katherine Annan - Can the outcome of Colles’ Fractures be
predicted by initial management: a retrospective analysis of
patients treated in Auckland City Hospital
Aaron Yap - The detection of choroidal melanoma in the
New Zealand population
Craig Ball - NZ Rotator Cuff Registry
ORL – Head and Neck Surgery:
Caitlin Bodian - Audit of the incidence of deep vein
thrombosis and pulmonary embolism after joint
replacement surgery in 2000 patients
Theodore Athanasiadis - Audit of epidemiology
and treatment outcomes for recurrent respiratory
papillomatosis within the ADHB
Andrew Johnston - Allograft-Prosthetic composite graft in
the proximal tibia: short term results
Elizabeth Broadbent- Patient and Family Coping with Head
and Neck Cancer
Tadeusz Piszel - Delay of fractured neck of femur surgery
due to new anticoagulants (Dabigatran/Rivaroxaban) in
Auckland Population
Emke van den Broek - In-office bilateral injection
laryngoplasty as an adjunctive treatment for recalcitrant
puberphonia: a case report and review of the literature
Orthopaedics (Starship):
Danny Wong - A retrospective case-control study on the
use of V1STA Negative Pressure Wound Therapy in the
management of Pharyngocutaneous and orocutaneous
fistula in patients who have had major head and neck
surgery
ORL (Starship):
Nikki Mills - Prospective descriptive study of infectious
aetiology of otitis media and nasopharyngeal bacterial flora
of children in New Zealand under changing pneumococcal
vaccination schedule
42
Graeme van der Meer - Day Stay paediatric tonsillectomyconfirmation of safety and efficacy in New Zealand
John Ferguson - A Retrospective Multicenter Review of
Early Onset Spinal Deformity Patients That Underwent
Either a Primary or Revision Spinal Bracing Procedure
with the Ellipse Technologies MAGEC Spinal Bracing and
Distraction System
Jillian Lee - Ultrasound in upper limb peripheral nerve
injuries: can this affect our surgical decision making?
Anna Mackey - Incidental findings on hip surveillance in
cerebral palsy
Zaid Matti - Outcome of fractures reduced under Ketamin
in ED
Sarah Murgatroyd - A prospective observational study of
current clinical features, microbiologic, radiographic and
treatment outcomes of spinal infection
Adrienne Socci - Applying a clinical prediction algorithm
for differenciating between septic arthritis and transient
synovitis in New Zealand
Susan Stott - The New Zealand Cerebral Palsy Register
Susan Stott - BMI of Paediatric Orthopaedic Patients
Susan Stott - The kinematics of inclined walking in children
with Cerebral Palsy
Nichola Wilson- The Feasibility of outcome measures
assessing activity and participation in early recovery from
lower limb orthopaedic surgery in children and adolescents
with Cerebral Palsy
Paediatrics:
Cayley Ingham - Patient Satisfaction with the Starship Developmental Paediatrics Outpatient Service
Patrick Kelly - Evaluating New Zealand’s first multi-agency
for child protection
Patrick Kelly - Relationship between known family violence
or reports of concern to Child Youth and Family and nonaccidental head injury in children under two years of age
Patrick Kelly - Do children admitted to Starship with
structural head injury and not referred to Te Puaruruhau
(the Starship Child Protection Team) differ from those
who are referred, and is there a need to develop referral
criteria?
Aimee Kettoola - Developmental Screening of Refugee
Children under 5 Years Old Arriving in New Zealand (NZ)
Diana Lennon - Genetic background of susceptibility to
Rheumatic Fever
Jonathan Bishop - Surveillance studies undertaken by the
New Zealand Paediatric Surveillance Unit
Alison Leversha - Rheumatic Fever in WDHB and ADHB: an
audit of admissions over 2009-2011
Phillipa Clark - Audit of microarray karyotype testing done
on Developmental Paediatric team in 2011- a look at the
process from consent to sharing of results
Alison Leversha - Streptococcal and Staphylococcal load
among primary school children: The impact of a school
based health intervention targeting sore throats and skin
sepsis
Phillipa Clark - What do NZ paediatricians say about
services for young people with a dual diagnosis – an
internet based survey?
Colette Muir - Transition of Medical Care for Young People
with Disabilities
Cameron Grant - Understanding ICD-9-CM-II coding of
emergency department visits for food related allergic
reactions. Auckland District Health Board chart review
1988-2011
Cameron Grant - Severe life threatening pertussis in the
whole cell and acellular vaccine eras
Tori Hayward - How well do we identify developmental
problems among preschool children admitted to Starship
Children’s Hospital?
Lynne Hutchison - Treatment policy in infants with
deformational plagiocephaly/brachycephaly: a comparison
of beliefs, attitudes and treatment practices between New
Zealand and the Netherlands
Hilda Mulligan - Participation of children with physical
disability in leisure activities in New Zealand
Jeanine Nunn - Audit of forensic medical examinations
completed by Te Puaruruahau for child and adolescent
victims of sexual assault
Neerali Parbhu - Paediatric Hospital Experiences: Sprout IV
pole evaluatio
Jan Sinclair - Randomised placebo controlled study of
vitamin D during pregnancy and infancy
Mark Taylor - Audit of patient initiated follow up in the
general paediatric outpatient department at Starship
hospital
43
Paediatric Intensive Care Unit:
John Beca - Randomised controlled trial of a combination of
Dexamethasone and Adrenaline for Bronchiolitis (DAB Trial)
John Beca - The SAFE Extrapolation to Paediatric Intensive
Care (SAFE-EPIC) Study
John Beca - Sedation and delirium practice in Paediatric
Intensive Care Units: Australian and New Zealand
Observational Study (Baby Spice)
John Beca - Sepsis Prevalence Outcomes and Therapies
John Beca - Developmental and functional outcomes in
school-age children after neonatal surgery for congenital
heart disease
Elizabeth Segedin - Epidemiology of Paediatric Chronic
Illness in Australia and New Zealand
Helen Waldron - PATRONuS- Predicting eArly exTubation
after Routine heart Surgery y
Pain Services:
Deborah Bean - Descriptions of Pain Severity, Disability &
Psychological Factors in Chronic Low Back Pain and Complex
Regional Pain Syndrome
John Beca - Point Prevalence study of Plasma Transfusion
Exposure
Deborah Bean - electronic Persistent Pain Outcomes
Collaboration (ePPOC)- an initiative to support continuous
improvement in the quality and effectiveness of pain
management in Australasia
Anusha Ganeshalingham - The New Zealand Pertussis
Experience
Malcolm Johnson - The Daily Relationships between Sleep
and Pain: A Diary Study
Anusha Ganeshalingham - VA ECMO versus conventional
therapy in severe paediatric sepsis- a tale of two cities
Malcolm Johnson - The temporal relationships between
sleep, daily activity and cognitive arousal in insomnia and
chronic pain
Alistair Gunn - EEG biomarkers of brain injury in newborn
babies
Jonathan Lillie - Does MRI predict prognosis for children
who suffer cardiac arrest prior to PICU. A retrospective
review of MRIs and case notes of approximately 70 children
who presented to Starship PICU between 2003 and 2012
Katie Moynihan - New Zealand’s national paediatric
intensive care transport service. A 10 year review of
interhospital retrievals
Julie Myers - Fatigue in clinicians who undertake regular
aeromedical transport work
Gabrielle Nuthall - Observation of multi centre quality
improvement project: Improving safety and quality of
tracheal intubation practice in paediatric intensive care
units and paediatric emergency departments
Rebecca Pearce - 7 year retrospective audit of All Terrain
Vehicle injuries admitted to Starship Hospital
44
Alex Psirides - Characteristics and outcomes of Medical
Emergency Team (MET) call in NZ. A prospective observational study
Sarah McCambridge - Addressing intimacy and sexual
functioning within a pain clinic. Perspectives from chronic
pain patients
Jane Thomas - A qualitative survey of chronic pain in
adolescents and young people attending the Auckland
Regional Pain Service
Palliative Care (Adult):
Gary Bellamy - Understandings of, and preferences for,
Advance Care Planning (ACP) amongst current and future
consumers of health care: an exploratory study
Merryn Gott - How can the costs of providing care for
family and whanau within a palliative care context be
appropriately captured for research purposes?
Jackie Robinson - Benefits and burdens of hospital
admissions for patients with palliative care needs
Shamsul Shah – ‘Mens sana in corpore sano’: A sound
mind in a healthy body. Healthcare staff’s perceptions of
spirituality and spiritual care at Auckland City Hospital
Physiology
Brooke Cantley - Establishing a reference set for
cardiovascular autonomic responses in a local population
Kevin Ellyet - Sampling of pulmonary function and
cardiopulmonary exercise parameters from a normal New
Zealand population
Anya Lindsay - Is there a significant difference in
parasympathetic/sympathetic tone in bronchial asthmatics
that respond positively to a beta-2 agonist compared to
non-responsive bronchial asthmatics?
Public Health:
Michael Hale - Does a pertussis vaccine during pregnancy
reduce neonatal infection?
Simon Thornley - Is dental caries a risk factor for mortality,
and hospital treatment for rheumatic fever, cancer,
asthma, pneumonia, middle-ear infection, and behavioural
disorders?
Alistair Woodward - Are our babies getting bigger?
Radiology (Adult):
Brendan Buckley - Experience with Cyroablation for treating
tumours at ADHB
James Caldwell - A retrospective audit of patients
presenting to Auckland City Hospital with primary
intracerebral haemorrhage
James Campbell - A Radiological Study of the anatomy and
normal variation of the Tibiofibular interosseous ligament
Andrew Holden - Safety and feasibility study of the
Shockwave Lithoplasty ™ System
Andrew Holden - Prospective, Non-Randomized, SingleArm, Multi-Center, Pharmacokinetic Study for the
Treatment of Subjects Presenting with De Novo Occluded/
Stenotic or Re-occluded/Restenotic Lesions of the
Superficial Femoral or Popliteal Arteries Using
Andrew Holden - MAJESTIC: Stenting of the Superficial
FeMorAl and/or Proximal Popliteal Artery proJEct with
BoSTon ScientifIC’s Innova drug eluting stent
Andrew Holden - ILLUMINATE: ProspectIve, SingLe-Arm,
Global MuLti-Centre Study to EvalUate TreatMent of
Obstructive SupErficial Femoral Artery and/or Popliteal
LesioNs With A Novel PacliTaxel-CoatEd Percutaneous
Angioplasty Balloon
Andrew Holden - An Evaluation of the 480 Biomedical
STANZA Drug-Eluting Resorbable Scaffold (DRS) System in
the Treatment of de novo SFA Lesions- The SPRINT Study
Andrew Holden - ADVANCE – Clinical Evaluation of the
Advance 35 Scoring PTA Balloon Dilatation Catheter
Andrew Holden - Safety and Performance Study of the
Shockwave LithoplastyTM System
Andrew Holden - Prospective, Multicenter Tack Optimized
Balloon Angioplasty Below the Knee (TOBA-BTK) study
for Infrapopliteal Arteries using the Tack-it Endovascular
System
Andrew Holden - ZIlver PTX Thumbwheel Delivery System
Andrew Holden - Seven centre, physician-initiated,
retrospective audit of early experiences with the Nellix
device, since commercialisation in March 2013
Andrew Holden - Comparison of QISS versus CEMRA at 3T’
Andrew Holden - A prospective, multi-centre, nonrandomised, single-arm study of the Bard LifeStream
Balloon Expandable Vascular Covered Stent in the
Treatment of iliac artery occlusive disease (BOLSTER)
Andrew Holden - Novel Endovascular Access Trial (NEAT):
A Study of the LFEX System for Percutaneous AV Fistula
Creation in Haemodialysis Patients
45
Radiology (Adult): continued
Andrew Holden - Emba Peripheral Embolization Device
(EPED) Study
Henry Kwok - The use of multidector CT in the evaluation
of non-occlusive mesenteric ischaemia in cardiovascular
intensive care patients
Martyn Nash - Tracking breast cancer across different
imaging modalities using biomechanical models
Sahan Wadasinghe - Pelvicaliectasis of pregnancy: defining
normal
Radiology (Starship):
Jules Kieser - Retrospective Analysis of Rib Injury Patterns
and Frequency in cases of Non-accidental Injury
Ali Mirjalili - Surface anatomy of the sciatic nerve in the
gluteal region in the paediatric population
Poul Nielsen - Collection of computed tomography (CT) and
magnetic resonance imaging (MRI) from human infants for
research into Shaken Baby Syndrome and modelling the
second stage of labour
RehabPlus:
Sureshbabu Subramanian - Slow stream rehabilitation;
review of outcomes
Renal Services (Adult):
John Collins - New Zealand Peritoneal Dialysis Registry
John Collins - SHARP-ER Study of Heart and Renal
Protection- An extension study to SHARP OTA/03/11/116
John Collins - Assessing the benefits of prescribed exercise
in clinical populations
John Collins - Removal of selected low molecular weight
highly proteinbound uraemic toxins in patients on
peritoneal dialysis
John Collins - The CKD-FIX Study: an investigator-initiated,
multicentre, prospective, randomised, double-blind,
placebo-controlled; parallel-arm trial testing the hypothesis
that compared to placebo
46
Michael Collins - The INTENT trial: The effect of intensive
nutrition interventions on weight gain after kidney
transplantation- a pilot randomised controlled trial
Janak de Zoysa - RITAZAREM: An international, open label,
randomised controlled trial comparing rituximab with
azathioprine as maintenance therapy in relapsing ANCAassociated vasculitis
Ian Dittmer - Outcomes in hepatitis B renal transplant
patients
Ian Dittmer - A Phase 3, Randomised, Double Blind, Placebo
controlled Study of the Efficacy and Safety of FG-4592 for
the Treatment of Anemia in Chronic Kidney Disease Patients
not on Dialysis, FibroGen
Enya Ho - ABO-incompatible live donor kidney
transplantation- our experience to date
Chun-Yuan Hsiao - To determine incidence, clinical
characteristics and outcome of renal transplant recipients
with BK viraemia and/or BKV nephropathy in the greater
Auckland region between 2008 and 2013
Angela Jackson - Living renal donor transplantation: does
local vs regional evaluation impact on patient outcomes
Paul Manley - Transplantation and Diabetes (Transdiab):
A Pilot Randomised Controlled Trial of Metformin in prediabetes after kidney transplantation
Helen Pilmore - New Zealand Survey of Glomerulonephritis
Helen Pilmore - SONAR: Study Of Diabetic Nephropathy
with Atrasentan. A Randomized, Multicountry, Multicenter,
Double-Blind, Parallel, Placebo Controlled Study of the
Effects of Atrasentan on Renal Outcomes in Subjects with
Type 2 Diabetes
Damodara Reddy Thangella - Exploring the Adequacy of
Haemodialysis Treatment in Chronic Kidney Patients in
Satellite Haemodialysis Units, Auckland District Health
Board
David Semple - A randomised, controlled trial of low
sodium dialysate versus conventional sodium dialysate
to reduce left ventricular mass index in patients receiving
home haemodialysis: The SOdium Lowering In Dialysate
(SOLID) trial
David Semple - The genetic causes of renal disease in
Aotearoa New Zealand
Tonya Kara - Global Assessment of Acute Kidney Injury
Incidence and Outcomes: Global Snapshot
Elizabeth Stallworthy - End of life care preferences and
needs: perceptions of satellite and incentre haemodialysis
patients treated by Auckland District Health Board
Chanel Prestidge - Audit of imaging peri utetic stent
removal post paediatric renal transplant
Sarah Tan - Positive complement-dependent cytotoxicity
crossmatch live donor kidney transplantation
Tina Sun - Inflammatory profile and clinical outcomes
associated with Icodextrin ® in a cohort of peritoneal
dialysis (PD) patients in Auckland City Hospital
Maha Yehia - Percutaneous renal biopsy in high risk
patients: complications and alternative literature search
Maha Yehia - Supported guideline implementation in
a network of peritoneal dialysis units: quality of life
assessment sub-study
Maria Stack- Genetic basis of Kidney Disease in New
Zealand Children
William Wong - Thrombotic thrombocytopenic purpura
(TTP) Registry
William Wong - Clinical and genetic features of Dent’s
disease in a NZ pedigree
Respiratory Services (Adult):
Renal Services (Starship):
Tim Christmas - A Phase III, randomized, double-blind,
placebo controlled study to assess the efficacy and safety
of lebrikizumba in patients with uncontrolled asthma who
are on inhaled corticosteroids and a second controller
medication
Louise Alberella - A retrospective audit of renal function pre
and post liver transplantation in New Zealand children with
biliary atresia
Tim Christmas - Post operative srveillance of NSCLC
following resecrion for curative intent- does it offer any
benefit to patients?
Carol Chan - The follow up and outcome of children
requiring renal replacement therapy for acute kidney injury
following cardiac surgery
Hanna Fontinha - Determining if an association exists
between heart rate variability (HRV) and the outcome
of saline bronco-provocation and/or exhaled nitric oxide
(eNO) testing in asthmatics
Sarka Davidkova - The utility of reticulocyte haemoglobin
to assess iron availability and anaemia in paediatric dialysis
patients
Tonya Kara - Retrospective review of paediatric liver
transplant patient looking for predictors of renal
dysfunction
Tonya Kara - A retrospective review of analgesia in
paediatric renal transplant recipients
Tonya Kara - Examining the health of mother’s with renal
transplants in pregnancy and factors that may affect the
growth and health of the baby
Alaina Francis - Do underwater hockey players show
a significant difference in heart rate variability during
exposures of hypoxia and hypercapnia compared to normal
subjects?
Clair King - To examine the relationship between measures
of pulmonary function and lung morphology as measured
by HRCT in a cohort of elderly subjects
Clair King - The diagnostic accuracy of partial sleep studies
compared with PSG in an unselected group of attendees to
OSA clinics
Tonya Kara - Risk Factors for recurrent paediatric focal
segmental glomerulosclerosis post transplantation
47
Respiratory Services
(Adult): continued
John Kolbe - Protocol Gb27980: A Phase Iib, Randomized,
Double-Blind, Placebo-Controlled Study To Evaluate The
Efficacy, Safety, And Dosing Regimens Of Memp1972a
In Adults With Allergic Asthma Who Are Inadequately
Controlled On Inhaled Corticosteroids
Tanya McWilliams - A 12-Week Dose-ranging Study
to Evaluate the Efficacy and Safety of Fp Spiromax®
(Fluticasone Propionate Inhalation Powder) Administered
Twice Daily compared with Placebo in Adolescent and Adult
Subjects
John Kolbe - A multicenter, randomised, blinded, activecontrolled, parallel-group study to compare the efficacy,
tolerability and safety of NVA237 compared to tiotropium
added on to fluticasone/salmeterol in patients with chronic
obstructive pulmonary disease
Rachel Vicars - Patient evaluation of CPAP therapy comfort
John Kolbe - A Phase 2b, Randomized, Double-Blind,
Placebo-Controlled Multi-Center Study Evaluating Antiviral
Effects, Pharmacokinetics, Safety, and Tolerability of GS5806 in Hospitalized Adults with Respiratory Syncytial Virus
(RSV) Infection
Margaret Wilsher - A randomised controlled trial of
conservative versus interventional treatment of primary
spontaneous pneumothorax
John Kolbe - Long Term Administration of Inhaled Mannitol
in Cystic Fibrosis – A Safety and Efficacy Trial in Adult Cystic
Fibrosis Subjects
John Kolbe - A Multicenter, Randomized, Double-Blind,
Placebo-Controlled Study to Evaluate the Safety and
Efficacy of Pulmaquin® in the Management of Chronic Lung
Infections with Pseudomonas aeruginosa in Subjects with
Non-Cystic Fibrosis Bronchiectasis, including 28 Day OpenLabel Extension (ORBIT-4)
John Kolbe - A phase III, 52 week, randomized, doubleblind, 3-arm parallel group study, comparing the efficacy,
safety and tolerability of the fixed dose triple combination
FF/UMEC/VI with the fixed dose dual combinations of
FF/VI and UMEC/VI, all administered once-daily in the
morning via a dry powder inhaler in subjects with chronic
Christopher Lewis - A review of the ADHB Thoracic
Multidisciplinary meeting and the accuracy with which
decisions made via this process are translated into patient
care
Michael Maze - Therapeutic drug monitoring of Rifampicin
and Isoniazid at Auckland District Health Board 2005-2012
48
Margaret Wilsher - Correlation between HRCT extent and
pattern of disease and pulmonary function tests at 6 and 12
months in newly diagnosed or newly treated sarcoidosis
Margaret Wilsher - The association between serial serial
HRCT measures and lung function parameters in sarcoidosis
Margaret Wilsher - A randomised double blind, double
dummy parallel group study to compare the efficacyand
safety of fluticasone propionate/formoterol fumarate
(flutiform) 500/20ug BID and 250/10ug BID versus
salmeterol/fluticasone (Seretide) 50/500ug BID in subjects
with chronic obstructive pulmonary disease (COPD)
Margaret Wilsher - The clinical utility of chest CT in chronic
unexplained cough.
Conroy Wong - A Randomised Trial of Tiotropium
Treatment for Bronchiectasis
Respiratory (Starship):
Cass Byrnes - Bronchiectasis Exacerbations Study (BEST) in
Australia and New Zealand
Cass Byrnes - Azithromycin Bronchiolitis Inteverntional
Study 2
Cass Byrnes - A randomised controlled trial of effects of
early life exposure to general anaesthesia on neurocognitive
and behavioural outcomes in children with cystic fibrosis
(CF)
Cass Byrnes - A phase 3 multi-centre randomized placebocontrolled study of azithromycin in the primary prevention
of radiolgoically-defined bronchiectasis in infants with cystic
fibrosis
Thomas McNeilly - Use of Cardiovascular risk calculators in
patients with Rheumatoid Arthritis
Cass Byrnes - COB: Cost of Bronchiectasis
Fiona McQueen - DECT to investigate urate deposition
in the kidneys in patients with tophaceous gout and its
association with renal function
Cass Byrnes - Clinical and psychosocial changes over late
childhood and adolescence and early life determinants of
long term clinical outcomes in cystic fibrosis
Fiona McQueen - MRI inflammation as an imaging
biomarker in rheumatoid arthritis: monitoring response to
the “Treat to Target” approach
Steve Heap- The updated UTI Guideline: translating into
practice?
Simon Otter - A survey of the epidemiology of foot
complaints in systemic lupus erythematosus
Rheumatology (Adult):
Keith Rome- The effect of chronic gouty arthritis on the
structure and function of the Achilles tendon
Nicholas Cao - Development of the gout recommendation
adherence scale: an evaluation of reliability and validity
Nicola Dalbeth- Study To Look At How Effective And Safe
Lesinurad Plus Febuxostat Is Compared To Febuxostat Alone
In People With Gout Who Have Tophi (CRYSTAL)
Nicola Dalbeth - Study To Look At How Effective And Safe
Lesinurad Therapy Is Compared To Placebo In People With
Gout Who Are Unable To Take Standard Therapy (LIGHT)
Nicola Dalbeth - Investigation Of Genetic Susceptibility
Alleles In Ankylosing Spondylitis, And The Prevalence And
Severity Clinical Features
Nicola Dalbeth- ACR-EULAR multi-centre, case-control
study of classification criteria for gout
Nicola Dalbeth - A phase 3 randomised, double blind,
multicentre, placebo-controlled, combination study
to evaluate the efficacy and safety of Lesinurad and
Allopurinol compared to Allopurinol alone in subjects with
gout who have had an inadequate hypouricemic response
to
Nicola Dalbeth - An audit of the safety and efficacy of
benzbromarone in the management of gout in New
Zealand
Keith Rome - Footwear for patients with gout: a feasibility
study
Keith Rome - Foot and ankle characteristics associated with
falls and falls risk in people with rheumatoid arthritis
Keith Rome - The clinical effectiveness of footwear in the
reduction of pain and disability of people with gout
Ravi Suppiah- RITAZAREM: An international, open label,
randomised controlled trial comparing rituximab with
azathioprine as maintenance therapy in relapsing ANCAassociated vasculitis
Ravi Suppiah - New Zealand Vasculitis Study (NZVAS)
Vicky Tai - The experience and impact of living with
Behcet’s diseases: a qualitative study using the grounded
theory method
Sexual Health Services:
Massimo Giola - Knowledge, attitudes and practices
towards viral hepatitis among men who have sex with
men attending the Auckland Sexual Health Service; a selfadministered questionnaire to inform future educational,
screening and preventive interventions
49
Sexual Health Services: continued
Massimo Giola - “Care cascade” audit of viral hepatitis
screening and prevention in men who have sex with men
(MSM) presenting to the Auckland Sexual Health Service for
sexually transmissible infection (STI) screening
Susan Jensen - Investigation into anal sex practice and
knowledge in a cohort of Heterosexual clients attending at
Auckland Regional Sexual Health Service
Ian Bissett - In vivo characterisation of pressure wave
propagation across healed colorectal anastomoses
in patients with long-term post-operative evacuatory
dysfunction using high resolution
Surgery (Adult):
Elizabeth Broadbent - Does written emotional disclosure
improve wound healing in surgical patients?
Cynthia Benny - Lower gastro-intestinal bleeding: patient
characteristics, types of investigation and how this can
be applied to a framework for requesting radiological
investigations
Richard Douglas - p16 as a surrogate biomarker for the
presence of Human Papillomavirus (HPV) infections in
oropharyngeal squamous cell carcinoma
Ian Bissett - Randomised double-blind placebo-controlled
trial of gastrografin in the therapeutic management of
prolonged postoperative ileus following elective surgery
Ian Bissett - In vivo characterisation of large bowel pressure
wave propagation in the peri-operative setting and across
healed colo-colic anastomoses using a high resolution
manometry catheter.
Andrew Jo - The diagnosis and management of postappendicectomy intra-abdominal collections
Rinki Murphy - The impact of bariatric surgery on diabetic
retinopathy progression in those with type 2 diabetes
Maxim Petrov - Patient-controlled versus stepwise oral
refeeding in acute pancreatitis: A randomised controlled
trial
Ian Bissett - Clinical factors predicting complete pathological
response following neoadjuvant chemoradiotherapy in
rectal cancer
Maxim Petrov - New insights in relation to risk factors of
DM (Diabetes Mellitus) after AP (Acute Pancreatitis)
Ian Bissett - Risk factors for the development of Anterior
Resection Syndrome following colorectal resection
Lindsay Plank - Effect of Preoperative Immunonutrition on
Outcome in Patients Undergoing Partial Hepatectomy: A
Randomised Pilot Study
Ian Bissett - Long-term follow up of renal function following
perioperative acute kidney injury: a multi-centre study
John Windsor- Redefining the basics: Goal directed fluid
therapy in acute pancreatitis
Ian Bissett - Early ileostomy closure- a retrospective review
and costs analysis
John Windsor - Physiological and compositional studies of
the human thoracic duct lymph
Ian Bissett - A retrospective review of outcomes for
admissions with acute diverticulitis (AD) at Auckland City
Hospital
John Windsor - A review of the computed tomography
scans of patients whom have had insertion of a
percutaneous drain for necrotizing pancreatitis
Ian Bissett - Outcomes following intestinal anastomotic
leaks in colorectal surgery
John Windsor - Measuring the compartment pressure of
the cavity containing pancreatic necrosis following insertion
of a percutaneous drain in patients with necrotizing
pancreatitis
Ian Bissett - Mapping motor activity within the
defunctioned ileocaecocolonic segment using high
resolution manometry
50
Ian Bissett - Tiger 2 self-advancing nasojejunal tube in
adhesive small bowel obstruction – A pilot study to assess
feasibility
John Windsor - Understanding enteral tube feeding
intolerance
Surgery (Starship):
James Hamill - Validity, Reliability and Responsiveness of a
New Multidimensional Location and Level of Intensity of
Post-Operative Pain Score (LOLIPOPS)
James Hamill - The Children's Interval Appendicectomy
(CHINA) study
James Hamill - Public campaign for driveway run over
prevention 2011/2012: did it work?
James Hamill - Sprayed Peritoneal Regional Analgesia in
Appendicectomy trial - SPRAY trial
James Hamill - Too much TV? Trends in television tip-over
trauma at a single trauma centre
James Hamill - In New Zealand children, what
demographics indicate a predisposition of skin and soft
tissue infections?
Shareena Lala - Enterobius vermicularis and the paediatric
appendix
Giorgio Stefanutti - Automated immature granulocyte
count (IGC) as a diagnostic test for acute appendicitis in
children: a prospective study
Kiarash Taghavi- Parathyroidectomy case series
Vipal Upadhyay- Paediatric Ovarian Lesions- our experience
at Starship Children's Hospital, New Zealand
Vipal Upadhyay - Management of paediatric umbilical
hernia at Starship Children's Hospital
Trauma Service
Shanthi Ameratunga - The ‘YourCall’ Study: The
effectiveness of text messaging to address hazardous
drinking behaviours among admitted trauma patients
Ian Civil - Long-term outcomes of TEVAR following
traumatic aortic transection in a New Zealand population:
What is the optimal strategy for ongoing surveillance?
Urology:
Vincent Chan - Audit of effectiveness of rectal swab
cultures prior to Transrectal ultrasound-guided (TRUS)
prostate biopsy
Vincent Chong - How effective is hyperbaric oxygen therapy
(HBOT) in the treatment of radiation induced cystitis
Jonathan Masters- Genetic and genomic technologies, and
survival from prostate cancer
Jonathan Masters - Is Intravesical BCG Used Effectively In
The Greater Auckland Area And What Is The Efficacy?
Jim Watson - Clinical validation of the use of different tissue
samples in the diagnosis of prostate cancer using multiple
RNA biomarker amplicon sequencing
Vascular Service:
Tom Burton - HbA1c and risk of amputation
Andrew Hill - GREAT (Global Registry for Endovascular
Aortic Treatment) Registry
Andrew Hill - Ethnic Variation in the incidence of Thoracic
Aortic Dissection
Carl Muthukumaraswarmy - Adoption of EVLT as the
primary treatment modality for varicose veins: the
Auckland City Hospital Experience
Craig Webster - Communication in the Hospital Ward- A
Patient-stay Diary Study
Gjurgjica Badzakova-Trajkov - An exploration of factors that
affect recovery from mild traumatic brain injury and the
persistence of post-concussion symptoms
51
Funding for Research
In 2012, 2013 and 2014 ADHB researchers and their
colleagues have enjoyed considerable success in obtaining funding for their research from public-good
sources.
52
A+ Trust Grants
A+ Trust Research Grants offer contestable research funding by the Auckland DHB Charitable Trust via a twice yearly
competitive round. The aim is to support ADHB researchers
from all disciplines and specialties to undertake research
across the health spectrum from patients to population,
disease to prevention, and service delivery to cost effectiveness and beyond. Applications are externally peerreviewed and assessed by the Research Review Committee
for scientific merit, feasibility, rationale and methodology,
deliverables, and opportunities to develop the capacity of
new researchers in the organisation. The below projects
were approved from 2012 through 2014:
Projects
Jane Alsweiler / Anna Tottman – Newborn- Long-term
neurodevelopmental consequences of neonatal hyperglycaemia and its treatment with insulin- $28,400.00
Rohan Ameratunga – Clinical Immunology- Evaluation of Tim-3
as a cellular marker in Immunodeficient patients.- $19,240
Johanna Bannister - Do interventions have a positive
impact on women who do disclose partner violence in
a health care setting?- $3,810
Kylie Becker / Lindsay Plank – Nutrition Services - Effect
of Preoperative Immunonutrition on Outcome in Patients
Undergoing Partial Hepatectomy: A Randomised
Pilot Study- $9,941
Rachael Bergman – Gastroenterology - Haemorrhage
alleviation with tranexamic acid-intestinal system.
(Halt-It)- $26,030
Jon Bishop – Paediatric Gastroenterology- Prospective
Study to assess validity of the use of serological markers to
diagnose Coeliac Disease in New Zealand children according
to ESPGHAN diagnostic guidelines- $28,178
Annaliesse Blincoe – Paediatric Immunology- Do Defects in
the Innate Immune System Contribute to Non-Cystic Fibrosis
Bronchiectasis in Maori and Pacific Island Children? – $30,000
Doug Campbell – Anaesthesia- Neurological Impact of Vascular
events In noncardiac Surgery patIents cOhort evaluatioN Study
(NeuroVISION)- $30,000
Debra Chalmers – Cardiovascular Intensive Care- A survey of
New Zealand public opinion on methods to triage intensive
care patients in an influenza pandemic- $30,000
Michael Collins – Renal- Optimal nutrition intervention to
prevent excessive weight gain post kidney transplantation:
pilot randomised controlled trial- $30,000
Barbara Cormack – Newborn- PROVIDE: The impact of Protein
Intravenous Nutrition on Development in preterm babies. A
randomised controlled trial of more intravenous protein in
the first week of life- $29931
Stuart Dalziel – Children’s Emergency Department- The
A-PHIRST study (Australasian Paediatric Head Injury Rules
Study): a prospective observational study comparing existing
paediatric minor head injury clinical decision rules.- $29,665
Jill Depledge – Women’s Health- The effect of exercise and
bracing on the width of the rectus abdomens diastasis in early
postnatal women, measured by ultrasound- $29,896
Kerry English – Anaesthesia- Cancelling Elective Surgery:
A Mixed Methods Study of the Impact on Quality of Life,
Postoperative Outcomes and Patients’ Socioeconomic
Standing- $30,000
Cindy Farquhar – Women’s Health- The Intrauterine
Insemination (TUI) Study- $25,000
Peter Fong – Oncology- Genetic analysis of ovarian granulosa
cell tumours (GCT)- $29,636
Kim Gear – Oral Health- The composition of subgingival plaque
bacterial and fungal profiles and their effects on the incidence
and severity of oral mucositis in head and neck cancer patients
receiving radiotherapy treatment- $29,327
Michael Gillham – Cardiovascular Intensive Care- MicroRNA
biomarkers for the early diagnosis of Non Occlusive Mesenteric
Ischaemia- $9,453
Devshana Gupta – Women’s Health- Endometrial injury in
women with subfertility undergoing IVF/ICSI or expectant
management; the Pipelle Injury in Pregnancy (PIP) studies$27,212
James Hamill – Paediatric Surgery- Sprayed Peritoneal Regional
Analgesia in Appendicectomy trial- SPRAY trial- $29,994
53
Jo Hegarty – Newborn- A dosing trial to determine the most
effective dose and frequency of prophylactic oral dextrose gel
in preventing neonatal hypoglycaemia- $29,995
James Houghton – Starship Anaesthesia- The impact of obesity
on the pharmacokinetics and pharmacodynamics of propofol
infusion in children – A PILOT Study- $30,000
Craig Jefferies - Paediatric Endocrinology- Clinical trial of
Zoledronic acid (Aclasta) in children and adolescents with
Duchenne muscular dystrophy- $30,000
Peter Jones - Humidified High-Flow Oxygen Therapy in the
Emergency Room Study- $30,000
Aimee Kettoola – Paediatric Endocrinology- Developemental
screening in refugee children- $16,156
Alison Leversha - Community Child Health and Disability
Service- Streptococcal and staphylococcal load among primary
school children: the impact of a school based health service
targeting sore throats and skin sepsis- $29,912
Alison Leversha – Community Child Health and Disability
Service- Streptococcal and Staphylococcal load among
primary school children: The impact of a school based health
intervention targeting sore throats and skin sepsis- $29,629
David Orr – Gastroenterology- Very low calorie diet (VLCD)
followed by fibre and probiotic supplementation is superior to
VLCD alone in achieving sustained weight loss and resolution of
Non-Alcoholic Fatty Liver Disease-$30,000
Celia Palmer – Palliative Care- A prospective cohort study of
tunnelled external peritoneal catheters for the management of
malignant ascites- $29,443
Rachael Parke - Cardiovascular Intensive Care Unit- Oxygen
therapy in non-intubated patients in the Intensive Care Unit. A
bi-national point prevalence study- $11,285
Rachael Parke – Cardiovascular Intensive Care Unit- Is fluid
resuscitation pro-inflammatory?- $28,817
Lucy Pemberton – Haematology- A Programme of
Development for Older Patients with Acute Myeloid Leukaemia
and High Risk Myelodysplastic Syndrome- $30,000
Paul Manly – Renal- Transplantation and Diabetes (Transdiab):
A Pilot Randomised Controlled Trial of Metformin in prediabetes after kidney transplantation- $30,000
Naveen Pillarisetti – Paediatric Respiratory- A study of lung
microbiome in non-CF bronchiectasis during stability and
infective exacerbations compared to healthy children- $29,094
Jonathan Masters – Urology- Genetic and genomic
technologies, and survival from prostate cancer.- $29,984
Helen Pilmore – Renal- High Sensitivity troponins in End Stage
Renal Failure: Correlations with outcome and changes over
time- $29,445
Colin McArthur – Critical Care Medicine- Australasian
Resuscitation in Sepsis Evaluation- $17,000
Fiona McQueen – Rheumatology- DECT to investigate urate
deposition in the kidneys in patients with tophaceous gout and
its association with renal function- $29,707
Justin Mora – Ophthalmology- An Epidemiological
Investigation of Congenital Eye Anomalies in New Zealand and
Australia- $29,566
Michel Neeff – Paediatric ORL- An investigation of the
relationship between the microbiology of chronic suppurative
otitis media and the subsequent inflammatory response$30,000
54
Gabrielle Nuthall – Paediatric Intensive Care Unit- Observation
of multi centre quality improvement project: Improving
safety and quality of tracheal intubation practice in paediatric
intensive care units and paediatric emergency departments.
NEAR-4-KIDS (National Emergency Airway Registry for Children)
- $30,000
Helen Pilmore – Renal- Assessment of Scoring for Renal
Transplantation Survival: comparison of methodology and
patient perceptions- $30,000
Kathryn Rice – Paediatric Cardiology- Echocardiographic
Review of Dynamic Diastolic Function and Preload Markers in
Fontan Patients- $27,764
Sally Roberts – LabPlus- Genetic analysis of emerging
ceftriaxone resistance among isolates of gonorrhoea- $9,736
Deb Rowe – Neonatal Intensive Care Unit- Needle electrodes
for continuous EEG monitoring in the NICU, a prospective
study of safety and efficacy- $30,000
Jan Sinclair / Cameron Grant – Paediatric Immunology- Vitamin
D status during pregnancy and infancy and the development of
atopy- $29,836
Maria Stack – Paediatric Renal- Genetic basis of Kidney Disease
in New Zealand Children- $10,000
Peter Stone – Women’s Health- An investigation of the effect
of antihypertensives on endothelial activation in preeclampsia
- $16,219
Ravi Suppiah – Rheumatology- An international, open
label, randomised controlled trial comparing rituximab with
azathioprine as maintenance therapy in relapsing ANCAassociated vasculitis- $13,518
Elsa Taylor – Starship Anaesthesia- Parecoxib pharmacokinetics
and pharmacodynamis in children- $13,600
Mark Thomas - A Survey of New Zealand Public Concerns
about the Ebola Virus- $16,184
Greg Williams – Paediatric Intensive Care Unit- Audit of the
new Starship Paediatric Early Warning Score system – Phase I
of a Validation and Assessment Programme- $27,100
Deborah Williamson – LabPlus- A prospective observational
case-control study of the clinical and molecular epidemiology
of skin and soft tissue infections in paediatric patients
presenting to Starship Children’s Hospital Auckland, New
Zealand- $30,000
Summer Studentships
Emme Chacko - Mental Health Services for Older People
- Metabolic Side Effects of Atypical Antipsychotics in Older
Adults
Gary Cheung - Mental Health Services for Older People
- Assessing Capacity to Engage in Advance Care Planning in
Older People
Gary Cheung - Mental Health Services for Older PeopleRoutine assessment of depressive symptoms in older people
- the New Zealand experience with interRAI
Stuart Dalziel - Children’s Emergency Department- Ibuprofen
and Paracetamol in Asthma Causation (iPAC) feasibility study
Andrew Hill – Vascular Surgery- Ethnic variation in the
incidence of Thoracic Aortic Dissection
Kim Jamieson – Anaesthesia- Mastectomy pain audit:
Retrospective audit of the incidence of persistent pain
>6months post surgery for mastectomy patients
Peter Jones – Adult Emergency Department- The Effect of the
Shorter Stays in Emergency Departments Health Target on the
Quality of Discharge Information
Rohit Ramchandra – Physiology- What changes occur in the
chemoreceptor reflex during heart failure?
Peter Ruygrok – Cardiology- Outcome following heart
transplantation in Maori and Pacific Island patients: a
comparison with European New Zealanders
Peter Ruygrok – Cardiology- Confocal laser scanning
microscopy for assessment of cardiac allograft rejection
Helen Wihongi – He Kamaka Waiora- Trialling a National Māori
review form at the Auckland, Waitematā, and Wellington DHBs
Margaret Wilsher – Respiratory Services- The clinical utility of
chest CT in chronic unexplained cough
Ken Whyte – Respiratory Services- Determination of the
arterial blood pressure response to the forced vital capacity
maneuver in normal subjects and those with chronic
55
Greenlane Research
and Educational Fund
The Green Lane Research & Educational Fund (GLREF)
was started in 1971 at Green Lane Hospital with trustees
Alan Kerr, David Hill and Ken Graham, who all made
outstanding contributions to treating patients with heart
disease.
from Cardiology (which at that time was combined adults
During the 2013 year, the Fund supported salaries to the
and children), Cardiothoracic Surgery, Chest Medicine
value of $329,764 (John Neutze Research Scholarship
and Cardiac Anaesthesia. Money was raised from patient
and secretarial support for this, statistician and desktop
donations and occasional gifts and bequests. The Fund
administrator), awarded $331,894 in research support
now has Trustees from Adult Cardiology, Adult Cardiac
and $78,561 in conference support to nurses, technicians
Surgery, Paediatric Cardiology and Cardiac Surgery,
and other paramedical staff. An additional $65,746
Cardiac Anaesthesia and Intensive Care and Respiratory
was released from departmental restricted funds for a
Services. Its aims then and now are to support research
Transplant Fellowship, research and travel support, and to
and education within the departments represented by
bring keynote speakers to the Australasian TB Conference
trustees, with monthly meetings. Money was raised in
held in Auckland. At the Green Lane Dinner the Fund
a special initiative by John Neutze when he was head
celebrated the exceptional achievements of three former
of Cardiology to support a research scholarship (the
cardiac anaesthetists, Basil Hutchinson, Donald Stenhouse
John Neutze Research Scholarship), and Harvey White
and Stuart Kaye.
was subsequently appointed in a 5 tenths capacity in
During the 2014 year GLREF awarded $1,008,668 which
which he has remained. Over the last 12 years the trust
was the first time over the $1million mark. It supported
has supported a Senior Research Fellowship tenable
salaries to the value of $279,646 (John Neutze Research
for 3 years, annual large and small project grants on
Scholarship and secretarial support for this, statistician
a merit contested basis and a 3-year PhD Scholarship.
and desktop administrator), awarded research support
Applications for conference support are considered 3
of $218,371, two Senior Fellowships totalling $200,000,
monthly. The Fund also hosts an annual Scientific Session
a Transplant Fellowship of $50,000, a PhD Scholarship
followed by the Green Lane Dinner, at which a past
valued at $105,000, $65,000 in conference support to
member or members’ professional achievements
nurses, technicians and other paramedical staff and
are honoured.
a further $85,651 was released to various projects. A
During the 2012 year, the Fund supported salaries to the
new scholarship, called the Mornington Brennan Nurses
value of $283,970 (John Neutze Research Scholarship
Scholarship, valued at $5000 was initiated. At the Green
and secretarial support for this, statistician and desktop
Lane Dinner the Fund celebrated the achievements of the
administrator), awarded $228,150 in research support,
Physiology Department represented by Carol Ramage,
a PhD Scholarship valued at $105,000 and $75,018 in
Donna Aitken, Elaine Rush, Heather Nisbet, Margaret
conference support to nurses, technicians and other
Vedder, Noel Ashton, Sandy Long and Steve Withy.
paramedical staff. At the Green Lane Dinner the Fund
56
celebrated the achievements of three past surgeons,
Limited Budget Support
Srija Bhattacharyya – Cardiology- High sensitivity troponin T
after acute exacerbation of COPD ($10,000)
Alaina Francis – Respiratory Physiology- To determine whether
significant differences in physiological responses exist between
underwater hockey players and healthy controls ($21,460)
Mike Gillham – Cardiovascular Intensive Care Unit- To
complete a prospective pilot study of novel diagnostic
biomarkers in patients with clinically suspected non-occlusive
mesenteric ischaemia ($11,457)
Clair King – Respiratory Services- Pilot study examining lung
function and CT correlates in the ageing lung ($20,000)
Shay McGuinness – Cardiovascular Intensive Care UnitContribution to study to assess the safety, feasibility and brain
biomarker effect of 24 hours of therapeutic hypercapnia in
patients admitted to ICU after cardiac arrest ($10, 275)
Peter Ruygrok – Cardiology – Research salary support
($20,000)
Jonathon White – Cardiology- A cardiac MRI study
understanding troponin elevation in acute exacerbation of
COPD ($19,850)
Project Support
Richard Douglas – ORL- Studies of chronic rhinosinusitis
($69,601)
Sarah Fitzsimons – Cardiology- Prevalence of anaemia and iron
deficiency in patients with HF-PEF ($29,614)
Ghaz Jabur – Clinical Perfusion- Is cerebral autoregulation
disrupted by emboli exposure during cardiopulmonary
bypass ($48,776)
Shay McGuinness - Cardiovascular Intensive Care Unit-Study
of the control of oxygen levels during cardiopulmonary
bypass ($80,000)
John Ormiston, Mark Webster – Cardiology- Construction
of a coronary artery anatomical atlas for PCI ($50,000)
Kathryn Rice – Paediatric Cardiology- Dynamic ventricular
function in the Fontan circulation ($23,000)
Jon Skinner – Paediatric Cardiology- Targeted Next Generation
Sequencing to identify the genetic causes of heritable cardiac
disorders ($48,882)
Tim Willcox – Clinical Perfusion- The Goal Directed Perfusion
Trial ($38,000)
Margaret Wilsher – Respiratory Services- High flow oxygen
therapy in the emergency room ($98,300)
Margaret Wilsher – Respiratory Services – The Pneumothorax
Study ($42,500)
Senior Fellowships
Pau Medrano-Gracia - Improving coronary stenting design and
patient outcomes ($200,000)
Kathryn Waddell-Smith – Paediatric Cardiology- The change
in QTc around puberty in long QT syndrome and adherence to
beta-blocker therapy ($100,000)
PhD Scholarship
Kathleen Gilbert - Left and right ventricular function in
congenital heart disease ($105,000)
June Lau - Simulation based optimization in the Cardiac
Intensive Care Unit- optimizing the cardiac surgical patient
journey ($105,000)
Clair King – Respiratory Services- Correlation of functional
and morphological change in the aging lung ($73,466)
Cornelis Kruger – Cardiothoracic ORL Anaesthesia- Use of
etomidate vs propofol in patients undergoing cardiac
surgery ($58,981)
57
Auckland Medical Research Foundation
William Abbott – NZ Liver Transplant Unit – Travel Grant
Jane Alsweiler, Jo Hegarty – Newborn Services- Oral dextrose
gel for prevention of hypoglycaemia in at risk newborn infants
($140,672)
Jane Alsweiler – Newborn Services – Travel Grant
Rohan Ameratunga, See-Tarn Woon, Wikke Koopmans –
LabPlus – Molecular defects in common variable immune
deficiency ($54913)
Jennifer Weller, Alan Merry – Anaesthesia – Ian Civil –
Trauma – Improving team collaboration in the operating room
($123,626)
Kathryn Williamson – Newborn Services – Ruth Spencer
Medical Research Fellowship- Management of neonatal
hyperglycaemia ($257,333)
John Windsor – Surgery – Improving the surgical drainage of
necrotising pancreatitis ($28,761)
Ian Bissett – Surgery – Postoperative gut dysfunction ($63,500)
John Windsor – Surgery – Written emotional disclosure and
surgery ($151,616)
Cho Yui Bob Chan – Dermatology – Sir Harcourt Caughey
Award ($25,000)
John Windsor – Surgery – Travel Grant
Nicola Dalbeth – Rheumatology – Urate and bone ($157475)
Stuart Dalziel – Children’s Emergency Department –
Australasian Paediatric Head Injury Rules Study (APHIRST)
($114,000)
Robert Doughty – Cardiology – The PEOPLE Study ($70,000)
Cindy Farquhar – National Women’s Health – The TUI study
($78,500)
Fritha Hanning, Peter Fong, Reuben Broom – OncologyAccelerated BEP study, a randomised trial of accelerated versus
standard BEP chemotherapy for intermediate and poor-risk
advanced germ cell tumours ($56,000)
Nigel Lever – Cardiology – Mapping study of persistent atrial
fibrillation ($107,426)
Don Love, Ivone Leong – LabPlus – Jon Skinner – Paediatric
Cardiology- Long QT syndrome and hypertrophic
cardiomyopathy gene analysis ($50,000)
Soizick Mesnage – Medical Oncology – Sir Harcourt Caughey
Award ($25,000)
Dipika Patel – Eye Clinic – Travel Grant
Janet Rowan – National Women’s Health – Malcolm Battin –
Newborn Services – MiG TOFU: 7-9 yr olds ($73,683)
Chinthaka Samaranayake – General Medicine – Travel Grant
Timothy Short – Anaesthesia – Perioperative vascular events in
unrecognised obstructive sleep apnoea ($157,880)
Ralph Stewart – Cardiology – Technology and cardiac
rehabilitation ($153,003)
Andrea Vincent – Eye Clinic – Genetics of anterior corneal
dystrophy ($138,968)
58
Tom Wang – Cardiology – Travel Grant
Andrew Wood – Paediatric Oncology – Goodfellow
Repatriation Fellowship
Australian and New Zealand Society of
Nephrology
Michael Collins – Renal Medicine- Optimal nutrition
intervention to prevent excessive weight gain post kidney
transplantation: a randomised controlled trial ($10,000)
Cancer Society of New Zealand
Beth Caudwell – Oncology Research- Auckland Division of the
New Zealand Cancer Society Travel Grant awarded Sep 2012 to
attend the to attend the Australia New Zealand Gynaecological
Oncology Group (ANZGOG) Scientific Meeting in the Gold
Coast, Australia 20-23 Mar 2013 ($2240)
Kathryn Chrystal – Oncology- Phase II trial of weekly vs
3-weekly chemotherapy, in newly diagnosed ovarian cancer:
ICON 8 ($68,273)
Christine Crooks – Oncology Research- Auckland Division
of the New Zealand Cancer Society Travel Grant awarded
Sep 2013 ($2,265) to attend the Australia New Zealand
Gynaecological Oncology Group (ANZGOG) Scientific Meeting
in Canberra, Australia 26-30 Mar 2014 ($2265)
Sophie Goodger – Oncology Research- Auckland Division of the
New Zealand Cancer Society Travel Grant awarded Sep 2012 to
attend the TROG Annual Scientific Meeting in Wellington, New
Zealand 26 Feb – 1 Mar 2013 ($2432)
Ashish Joshi – Oncology Research- Auckland Division of the
New Zealand Cancer Society Travel Grant awarded Sep 2013
to attend the Australia and New Zealand Breast Cancer Trials
Group (ANZBCTG) Study Coordinator Workshop and Annual
Scientific Meeting, in Wellington, New Zealand 16-19 Jul 2014
($1502)
Leanne Joss – Haematology Research- Auckland Division of
the New Zealand Cancer Society Travel Grant in Mar 2012 to
attend the Haematology Society of Australia and New Zealand
(HSANZ) branch meeting in Dunedin 22-23 Mar 2012 ($980)
Andrew Macann – Oncology- Phase II comparison of two
chemoradiation regimes for HPV positive oropharyngeal cancer
($64,406)
David Porter – Oncology- SCUBA: Safe Chemotherapy using
both Arms ($26,418)
Vivian Sun – Oncology Research- Auckland Division of the
New Zealand Cancer Society Travel Grant awarded Sep 2013
to attend the World Conference on Lung Cancer in Sydney,
Australia 27-30 Oct 2013 ($2556)
Jane Wylie – Haematology Research- Auckland Division of
the New Zealand Cancer Society Travel Grant in Mar 2012 to
attend the Haematology Society of Australia and New Zealand
(HSANZ) branch meeting in Dunedin 22-23 March 2012
($1118)
Cardiac Society of Australia
and New Zealand
Christine Crooks – Oncology Research- Professional
Development Award May 2012 to attend the Australia and
New Zealand Breast Cancer Trials Group (ANZBCTG) Study
Coordinator Workshop and Annual Scientific Meeting, in
Hobart, Australia 18-21 Jul 2012 ($2000)
Carol Fraser-Browne – Oncology Research- Trust Professional
Development Award Dec 2012 to attend the European Society
for Radiotherapy and Oncology 2nd International Congress
Forum in Geneva, Switzerland, 19-23 Apr 2013 ($3000)
Ashish Joshi – Oncology Research- Professional Development
Award May 2013 to attend the Australia and New Zealand
Breast Cancer Trials Group (ANZBCTG) Study Coordinator
Workshop and Annual Scientific Meeting, in Brisbane, Australia
10-13 Jul 2013 ($2,500)
Michelle Mulligan – Oncology Research- Professional
Development Award Dec 2013 to attend the TROG Annual
Scientific Meeting Sunshine Coast, Australia 1-4 Apr 2014
($3000)
Vivian Sun – Oncology Research- Professional Development
Award Dec 2012 to attend the Beltas Good Clinical Practice
(GCP) Course 19-20 Mar 2013 ($865)
Julie Thomas – Oncology Research – Professional Development
Award Dec 2013 to attend the Australia New Zealand
Gynaecological Oncology Group (ANZGOG) Scientific Meeting
in Canberra, Australia 26-30 March 2014 ($2500)
Chris Ellis – Cardiology – 2012 Quality of Care Research Grant –
3rd New Zealand Acute Coronary Syndrome Audit
Gravida: National Centre for Growth
and Development
Indran Ramanathan – Cardiothoracic Surgery – 2013 Summer
Studentship – Outcomes for patients having repeat tissue valve
surgery ($5000)
Jane Alsweiler, Frank Bloomfield – Newborn Medical Services
- The impact of neonatal hyper- and hypo-glycaemia on the
development of the brain ($39,900)
Nigel Wilson – Paediatric Cardiology- 2013 Summer
Studentship – Defining the disease burden of Rheumatic Heart
Disease in the Wellington region ($5000)
Frank Bloomfield – Newborn Medical Service- Barbara
Cormack – Clinical Dietetics- ProVIDe: The impact of Protein
IVN on development. A feasibility study ($39,515)
Genesis Oncology Trust
Frank Bloomfield, Jane Alsweiler – Newborn Medical Service –
Barbara Cormack – Clinical Dietetics- Metabolic Outcome with
High Protein Intakes in Preterm Babies ($521,985)
Beth Caudwell – Oncology Research- Professional
Development Award May 2012 to attend the Australasian
Gastro-Intestinal Trials Group Annual Scientific Meeting in
Sydney, Australia 6-8 Sep 2012 ($2000)
Frank Bloomfield - Newborn Medical ServicesPericonceptional programming of adult adipose tissue
inflammation and insulin resistance ($30,000)
59
Frank Bloomfield – Newborn Medical
Service- Life as a twin begins at conception
($764,333)
Frank Bloomfield – Newborn Medical
service- Eating patterns in Maori preschool
children ($340,623)
Katie Groom – National Women’s Health
- Frank Bloomfield, Jane Alsweiler –
Newborn Medical Service – Barbara
Cormack – Clinical Dietetics- The
development of a national multicentre
perinatal clinical trials network – a
feasibility study ($40,000)
Health Research Council of
New Zealand
William Abbott – NZ Liver Transplant Unit
- Prediction of Serious Liver Inflammation
in Chronic Hepatitis B Virus Infection
($174,386)
Peter Bergin- Neurology- Clinical
Practitioner Research Fellowship- Use
of the EpiNet platform for clinical trials
and epidemiological studies in epilepsy
($905,000)
Peter Bergin – Neurology- Incidence
Study of Status Epilepticus in the Greater
Auckland Region ($671,782)
Frank Bloomfield, Jane Alsweiler –
Newborn Medical Services – Perinatal
Care and its Long-term Consequences
($3,622,591)
Stuart Dalziel – Children’s Emergency
Department – RCT of levetiracetam vs
phenytoin for status epilepticus in children
(CONSEPT) ($1,198,985)
Stuart Dalziel – Children’s Emergency
Department- Clinical Practitioner Research
Fellowship – Paediatric Emergency
Research ($766,067)
60
The EpiNet project
Dr Peter Bergin
A problem bedevilling research in epilepsy is that the condition is very
diverse and often of unknown cause. Drug companies tend to focus
on more common forms and it is very difficult to organise the required
number of study sites to get an adequate sample size of people with a
particular condition by conventional means. Dr Bergin is an Auckland
City Hospital epileptologist who over the past six years has developed an
electronic, web-based platform for conducting clinical trials in epilepsy.
Any specialist in epilepsy, appropriately qualified, would be able to enrol
an eligible patient in an EpiNet trial from anywhere in the world. This has
the potential to speed international research in epilepsy. Dr Bergin has
already achieved much by way of proving the concept with a number of
small grants and has recently had a significant boost when the Health
Research Council agreed to personal funding for Dr Bergin to continue
this work. The HRC awarded a five-year Clinical Practitioner Fellowship
which will enable him to further focus on this for five years. He is one of
only six people in New Zealand to
have received one of these grants.
The EpiNet study group is currently
planning a series of trials in
new-onset epilepsy. Patients who
have not previously been treated
with an antiepileptic drug will
be randomised to receive either
levetiracetam, sodium valproate,
carbamazepine or lamotrigine,
depending on the seizure type
and suitability of valproate. These
studies are being funded by the
Neurological Foundation of New
Zealand.
Dr Peter Bergin
Colin McArthur – Critical Care Medicine – Randomised trial
of hydrocortisone in critically ill patients with septic shock
($773,854) Colin McArthur – Critical Care Medicine – Standard
issue transfusion versus fresher red blood cell use in intensive
care ($775,723)
Colin McArthur – Critical Care Medicine – RCT of continuous
versus intermittent beta-lactam antibiotics in the critically ill
($213,894)
Colin McArthur – Critical Care Medicine- Early goal-directed
sedation in mechanically ventilated intensive care patients
($1,118,620)
Shay McGuinness – Cardiovascular Intensive Care – Permissive
Hypercapnia, Alveolar Recruitment and Limited Airway
Pressure in ARDS ($320,960)
Leukaemia and Blood Cancer
New Zealand National Research Grant
Lucy Pemberton – Haematology- AML LI1 trial: A programme
of development for older patients with acute myeloid
leukaemia and high risk myelodysplastic syndrome ($120,000)
Mercia Barnes Trust, Royal Australia and
NZ College of Obstetrics and Gynaecology
Katie Groom – National Women’s Health – Frank Bloomfield –
Newborn Services- The development of a national multicentre
perinatal clinical trials network – a feasibility study. ($20,000)
National Heart Foundation
Shay McGuinness - Cardiovascular Intensive Care Unit
- Restrictive vs. Liberal Fluid Therapy in Major Abdominal
Surgery- The RELIEF study ($770,667)
Ivone Leung – LabPlus- Purchase of equipment for targeted
and whole exome sequencing to identify the genetic causes of
long QT syndrome ($15,000)
Shay McGuinness - Cardiovascular Intensive Care Unit- Study
of the Control of Oxygen levels during cardiopulmonary bypass
($141,411)
Don Love – LabPlus- Mutation screening of cardiac genes in
Sudden Unexpected Death in the Young (SUDY) andSudden
Infant Death Syndrome (SIDS) patients ($126,048)
Claire McLintock – National Women’s Health – A national
population-based study of rheumatic heart disease in
pregnancy ($148,910)
Ralph Stewart – Cardiology- Evaluation of frailty and comorbidity in patients with severe heart disease ($150,000)
Rachael Parke – Cardiovascular Intensive Care – Fluid therapy
after cardiac surgery – a feasibility study ($137,356)
Tim Short – Anaesthesia – The influence of anaesthetic depth
on patient outcome after major surgery ($1,199,005)
Ralph Stewart – Cardiology- Evaluation of frailty and comorbidity in patients with ischemic heart disease ($350,000)
Ralph Stewart – Cardiology – Clinical Practitioner Research
Fellowship- Registry based clinical trials ($800,000)
Harvey White – Cardiology- Cost effectiveness of fractional
flow reserve in myocardial infarction ($350,000)
Nigel Wilson – Paediatric Cardiology – The significance of
rheumatic heart disease detected by echocardiography
($800,000)
Kathryn Waddell-Smith – Paediatric Cardiology – The Clinical
Cardiology Fellowship in Inherited Heart Disease
Tom Wang – Green Lane Cardiovascular Service- National
Heart Foundation Travel Grant – European Society of
Cardiology Congress, Amsterdam 2013 ($3500)
Neurological Foundation of New Zealand
Peter Bergin – Neurology- Randomised controlled trials of
patients with new onset epilepsy; EpiNet-First ($157,686)
Douglas Campbell – Anaesthesia- Neurological Impact of
Vascular events In non-cardiac Surgery patIents cOhort
evaluatioN Study, (NeuroVISION) ($171,530)
New Zealand Breast Cancer Foundation
Maria Pearse – Oncology – funding for a Research Fellow
to evaluate specific breast cancer projects using the data in
the Auckland Breast Cancer Study Group database and to
undertake laboratory research in breast cancer genomics
($113000)
61
New Zealand Society of Gastroenterology
Alex Lampen-Smith – NZ Liver Transplant Unit- Future care
preferences in patients with Child-Pugh C cirrhosis ($5,000)
David Orr– Gastroenterology- Very low calorie diet (VLCD)
followed by antibiotic and prebiotic supplement is superior
to VLCD in achieving sustained weight loss and resolution of
NAFLD Application ($5,000)
The Nurture Foundation for
Reproductive Research
Frank Bloomfield – Newborn Services- Protein IVN: Impact on
Development ($10,055)
Pritchard Coutts Charitable Trust
Nigel Patton – Haematology- UKALL4: A randomized trial for
adults with newly diagnosed acute lymphoblastic leukaemia
($53,500)
Trans Tasman Radiation Oncology Group
Dee Yang – Oncology Research- Trans-Tasman Radiation
Oncology Group (TROG) Conference Scholarship awarded
Jan 2013 to attend the TROG Annual Scientific Meeting in
Wellington, New Zealand 26 Feb – 1 Mar 2013 ($1400)
62
Promoting Research
at Auckland DHB
Research Events for
Auckland DHB
Celebration Week
Research Posters
ADHB Celebration Week (final week of November) was
the occasion, and ACH Level 5 Atrium was the venue, for
the 2012, 2013 and 2014 Research Poster Competitions
displays. Continuing the success of previous years, over 60
posters were on display every year, showcasing the commitment of our staff to research, and our expertise across
a diverse range of disciplines and topics. Winners for the
three judging categories are below.
Health Professions
Promoting Research
(Allied, Scientific, Technical)
2012 Winner – Stella Lai,
Diagnostic Genetics, LabPlus,
“Next Generation Sequencing approach and its use in
BRCA testing”
2013 Winner – Indira Basu,
Department of Microbiology, LabPlus,
“Genotype characterization of multi-drug resistant
Mycobacterium tuberculosis isolates in New Zealand
2002-2012”
2014 Winner – Jill Faulkner,
Microbiology, LabPlus,
“Homograft heart valve implantation culture results
January 2007 to April 2013”
63
Medical Nursing
2012 Winner – Reuben Broom,
Medical Oncology,
“RAD001 and zoledronic acid in renal cell carcinoma patients
with bone metastases (RAZOR): A randomized phase II trial”
2012 Winner – Nancy Naea,
Community Child health & Disability Service, Child &
Youth Health Team,
“Pacific people’s awareness and understanding of
Rheumatic Fever”
2013 Winner – Cindy Farquhar,
Women’s Health,
“A randomized controlled trial of fallopian sperm perfusion
compared with standard intrauterine insemination for women
with non-tubal infertility”
2014 Winner – Tom Wang,
Cardiology,
“Atrial fibrillation independently predicts short and long-term
mortality after aortic valve replacement”
2013 Winner – Karen Schimanski,
Adult Emergency Department and Assessment and
Planning Unit,
“Comparison of the Left Upper Arm and Forearm Non-invasive
Blood Pressures in Adult Emergency Department Patients: A
Randomised Cross-over Trial”
2014 Winner – Lianne McCarthy,
Cardiovascular Intensive Care Unit,
“A Randomised Controlled Trial Investigating the Effectiveness
of Self-administered Methoxyflurane for the Removal of Post
Cardiac Surgery Chest Drains”
Auckland DHB Young Investigator Award
The quality and impact of research undertaken by our junior clinical staff was also highlighted with the oral presentations for
the Young Investigator Award, 2012, 2013 and 2014. Each year five outstanding candidates were selected by a multidisciplinary
panel. The Physicians Grand Rounds, held in the Fisher and Paykel Clinical Education Centre in 2012 and 2013 and in the University of Auckland Grafton Campus in 2014, were attended by a large number of staff both past and present to hear the finalists’
presentations, which are listed below. Winners received $1000 Travel Prizes, funded by the A+ Trust.
2012 finalists
Matthew Boyle, Department of Orthopaedic Surgery, Starship
Children’s Hospital; Is ankle syndesmosis screw removal
required? A prospective, randomised, controlled trial
Tom Wang, Green Lane Cardiovascular Service, Auckland City
Hospital; Utility of high-sensitivity troponin after coronary
artery bypass grafting: characteristics and outcomes of type 5
myocardial infarction
Mary De Almeida, Department of Microbiology, LabPlus;
Clostridium difficile infection (CDI) due to the emergence of a
new hypervirulent strain, PCR-ribotype 244, in New Zealand
Garalynne Binford, Regional Eating Disorders Service; Normalised
Eating in the Treatment of Eating Disorders
Laura-Clare Whelan, Paediatric Intensive Care Unit; A pilot
study investigating the use of heated humidified oxygen and dry
oxygen therapy in children with acute respiratory illness
Matthew Boyle was judged the winner and
Mary De Almeida the runner-up.
2013 finalists
Tom Wang, Green Lane Cardiovascular Service, Auckland City
Hospital; Comparison of four contemporary risk scores for
predicting mortality and morbidity after aortic valve replacement
Ben Albert, Paediatric Endocrinology and Diabetes, Starship
Children’s Hospital; Neurodevelopmental outcomes in children
with congenital hypothyroidism treated with high-dose initial
replacement and close monitoring
64
Janarthanan Sathananthan, Interventional Cardiology; How
many dialysis patients receive transplantation after achieving
eligibility by undergoing coronary artery bypass grafting?
Kaitlin Fahey, Physiotherapy, RehabPlus; Should Elective Spinal
Surgeries be placed on the Physiotherapy Weekend Roster?
2013 finalists continued
Chris Cederwall, New Zealand Liver Transplant Unit;
Retrospective comparison of Radiofrequency and Microwave
ablation for Hepatocellular Carcinoma
Tom Wang was judged the winner and
Ben Albert the runner-up.
2014 finalists
Ghaz Jabur, Green Lane Clinical Perfusion, Auckland City Hospital;
Integrated arterial filters in new generation oxygenators: do they
cut the mustard?
2013 YIA Winner Tom Wang
Kylie Russell, Nutrition Services; Effect of Preoperative
Immunonutrition on Outcome in Patients Undergoing Liver
Resection: A Randomised Pilot Study
Leesa Pfeifer, Auckland Diabetes Centre; Modelling Alternative
Diabetic Ketoacidosis Management Protocols Suggests TwoHourly Blood Glucose Sampling Overnight Is Safe
Nicky Lawrence, Medical Oncology; Does endocrine therapy in
mucinous and tubular breast cancer improve outcomes?
Nick Gow, LabPlus; The role of echocardiography in
Staphylococcus aureus bacteraemia at Auckland City Hospital
Kylie Russell was judged the winner and
Nick Gow the runner-up.
2014 Young Investigator winner Kylie Russell with
Auckland DHB Chief Medical Office, Dr Margaret
Wilsher, and Dean of the Faculty of Medical and
Health Sciences, University of Auckland, Professor
John Fraser.
Children’s Research Centre Award
Generously funded by the Starship Foundation, and judged by
the Children’s Research Centre Advisory Committee, this award is
to assist staff of Starship Children’s Health to attend a conference
and present the findings of their project.
The 2012 winner was Laura-Clare Whelan, Staff Nurse, Paediatric
Intensive Care Unit, Starship Children’s Hospital, for her oral
presentation entitled “The Heated Humidification Study: A
pilot study investigating the use of heated humidification of low
flow oxygen in children” at the 4th Congress of the European
Academy of Paediatric Societies 2012, October 5-9 2012
Istanbul, Turkey. Wendy Yu, Department of Paediatric Surgery
and Urology, Starship Children’s Hospital, was the runner up.
The 2013 winner was Rebecca Walker, Department of
Paediatrics, University of Auckland. Rebecca gave a poster
presentation entitled “Risk factors for chronic otitis media with
effusion in Auckland children aged 3-5 years: a case-control
study” at the 7th Extraordinary International Symposium on
Recent Advances in Otitis Media – Stockholm- Sweden- June
12th-16th 2013.
65
Honours & Awards
Of those conducting research at ADHB,
many received honours and invitations
to showcase their accomplishments
from 2012 to 2014. While this list is
not exhaustive, we are pleased to
congratulate our researchers for the
following achievements.
66
Awards and Prizes
Ben Albert – Paediatric Endocrinology – 2013 Asia Pacific
Paediatric Endocrine Society Kaichi Kida Award
Kitty Bach – Newborn Services – Nominated in 2012 for
the University of Auckland Vice-Chancellor’s Prize for Best
Doctoral Thesis
Reuben Broom – Adult Oncology – Australian and New
Zealand Urogenital and Prostate Cancer Trials Group 2012
Annual Scientific Meeting – Best Oral Abstract Presentation
2012 for: RAD001 and zoledronic acid in renal cell carcinoma
patients with bone metastases (RAZOR) – a randomised
phase II trial.
John Collins – Renal Medicine - Kidney Health Australia Best
Clinical Science award at 2012 Australian and New Zealand
Society of Nephrology annual scientific meeting
Anthony Doyle – Radiology - RANZCR NZ Education Trust Prize
2012 and Rouse Travelling Fellowship 2013
Ed Gane – NZ Liver Transplant Unit – 2014 Health Research
Council of New Zealand Liley Medal
Abbey Jebb – Oncology - Young Investigator Prize - 4th
National Lung Cancer Conference, Auckland NZ, March
2012. An audit of cisplatin and vinorelbine use and tolerability
for patients receiving adjuvant treatment of non-small
cell lung cancer
Margaret Joppa – Oncology Research - 2013 PPD Excellence
Award in recognition of her contribution to the first interim
analysis for the C21005 Prostate Cancer Study
Alex Lampen- Smith – NZ Liver Transplant Unit – 2013
Gilead Young Investigators Award – Liver, NZ Society
of Gastroenterology
Tien Huey Lim – NZ Liver Transplant Unit – 2012 Roche
Young Investigators Award – Hepatology, NZ Society
of Gastroenterology
David Orr – NZ Liver Transplant Service – 2012 and
2013 NZSG-Ferring Research Fellowship, NZ Society
of Gastroenterology
Maggie Ow – Gastroenterology – Abbvie Best Hepatology
Paper/Poster at the New Zealand Society of Gastroenterology
Conference 2014
RadioHUM trial presentation – Radiation Oncology – at the
Royal Australia and New Zealand College of Radiology Annual
Scientific Meeting, Auckland, Oct 2013, Chris Atkinson Award
for best Radiation Oncology scientific paper presentation,
Elekta Award for best Radiation Oncology oral presentation
advancing the use of technology and the NZ Radiology
Education Trust Prize for the best proffered paper in
Radiation Oncology
Tom Wang – Cardiology – 2012 Cardiac Society of Australia
and New Zealand Young Investigator Award, 2013, Royal
Australasian Society of Surgeons Congress Young Investigator
Award (Cardiothoracic Surgery) and ADHB Young
Investigator Award
67
Health Research Council of New
Zealand’s Liley Medal awarded for
Hepatitis C breakthrough
Auckland District Health Board hepatologist and liver
transplant specialist Professor Ed Gane received the Health
Research Council of New Zealand’s distinguished Liley
Medal in 2014 for demonstrating a safer, more effective
treatment for people with hepatitis C virus. The Liley
Medal is presented annually to a recipient whose research
publication has made a significant contribution to health
and medical science.
The 2014 Liley Medal recognises Professor Gane’s
outstanding contribution to the health and medical
sciences in the field of clinical hepatology. Professor Gane
was the lead author on two very highly cited papers in
the prestigious medical journal, New England Journal of
Medicine, which showed that people could be cured of
the hepatitis C virus in just 12 weeks using an antiviral
treatment called sofosbuvir.
“Less than 1 per cent of New Zealanders infected with
hepatitis C are treated each year because the current
treatment, which uses interferon, is not very effective and
is poorly tolerated,” says Professor Gane.
Professor Ed Gane
Interferon occurs naturally in the human body. When extra
quantities of it are injected into the body, the immune
system is stimulated to fight off hepatitis C. Unfortunately,
because interferon is given by weekly injections at a much
higher dose than what the body produces naturally, it can
cause many adverse side effects.
The antiviral treatment successfully developed and tested
by Professor Gane has become the first interferon-free
treatment for people with hepatitis C infection.
“Hepatitis C virus has become the global and silent
epidemic of this century, affecting more than 180 million
people. Here in New Zealand, almost 50 per cent of adult
liver transplants are for hepatitis C virus-related liver
failure,” says Professor Gane.
“Hepatitis C virus has now overtaken hepatitis B virus as
the leading cause of liver cancer.”
“Even in infected individuals who never develop cirrhosis,
hepatitis C virus infection is often associated with fatigue
and reduced quality of life.”
The HRC’s Acting Chief Executive, Dr Tania Pocock, says
Professor Gane’s studies have been instrumental in helping to
develop safer, more effective and better tolerated therapies
for hepatitis C virus that are of short duration.
“The impact of this research is substantial due to the high
prevalence of the disease worldwide and the relatively simple
treatment developed and tested by Professor Gane,” says Dr
Pocock.
(Courtesy of Health Research Council of New Zealand)
68
Appointments to
Professional Societies,
Colleges, Advisory Boards,
Committees.
Professor Peter Ruygrok
Frank Bloomfield – Newborn Services- 2013 Guest Professor,
Chongqing Medical University, Chongqing, People’s Republic
of China, Guest Professor, Medical University of Kunming,
Kunming, People’s Republic of China, appointed to Ministry of
Health National Maternity Monitoring Group, 2012 appointed
as an Editor, Pediatric Research
Ed Gane – NZ Liver Transplant Unit -2013 University of
Auckland Honorary Professor Inaugural Lecture
James Pemberton – Cardiology – 2012 Fellowship of the
American Society of Echocardiography (FASE)
Peter Ruygrok – Cardiology - 2013 University of Auckland
Honorary Professor Inaugural Lecture
Ralph Stewart – Cardiology - 2013 University of Auckland
Honorary Professor Inaugural Lecture
Professor Ralph Stewart
69
Publications
70
Abbott, A.L., Adelman, M.A., Alexandrov, A.V.,
Barber, P.A., Barnett, H.J.M., Beard, J. et al.
Why Calls for More Routine Carotid Stenting
Are Currently Inappropriate: An International,
Multispecialty, Expert Review and Position
Statement. (2013) Stroke, 44, pp.1186-1190.
Abbott, W.G.H., Tsai, P., Ross, H.A., ‘Ofanoa, M.,
Trevarton, A.J., Hornell J., Munn S.R., Gane E.J.
Selection Pressure on the Hepatitis B Virus Pre-S/S
and P Open Reading Frames in Tongan Subjects
with a Chronic Hepatitis B Virus Infection.
(2012) Antiviral Research, 96, pp. 148-157.
Abizaid, A., Ormiston, J.A., Fajadet, J., Mauri, L.,
Schofer, J., Verheye, S., Dens, J., Thuesen,
L., Macours, N., Qureshi, A.C., Spaulding,
C. Two-year follow-up of the NEVO RESELUTION I (NEVO RES-I) trial: a randomised,
multicentre comparison of the NEVO
sirolimus-eluting coronary stent with the
TAXUS Liberté paclitaxel-eluting stent in
de novo native coronary artery lesions.
(2013) EuroIntervention, 9(6), pp. 721-729.
Abdul-Kadir, R., McLintock, C., Ducloy, A.-S.,
El-Refaey, H., England, A., Federici, A.B.,
Grotegut, C.A., Halimeh, S., Herman, J.H.,
Hofer, S., James, A.H., Kouides, P.A., Paidas,
M.J., Peyvandi, F., Winikoff, R. Evaluation and
management of postpartum hemorrhage:
Consensus from an international expert panel.
(2014) Transfusion, 54 (7), pp. 1756 - 1768.
Abdul Uloom, M.A. A rare case of massive
systemic embolisation secondary to atrial
myxoma- case report. (2013) Medical Journal
of Malaysia, 68 (6), pp. 471 - 472.
Abumaree, M.H., Chamley, L.W., Badri, M., ElMuzaini, M.F. Trophoblast debris modulates
the expression of immune proteins in
macrophages: A key to maternal tolerance of the
fetal allograft? (2012) Journal of Reproductive
Immunology, 94 (2), pp. 131-141.
Ackerley, S.J., Stinear, C.M., Barber, P.A., Byblow,
W.D. Priming sensorimotor cortex to enhance
task-specific training after subcortical stroke.
(2014) Clinical Neurophysiology, 125 (7),
pp. 1451 - 1458.
Adelson, P.D., Wisniewski, S.R., Beca, J., Brown,
S.D., Bell, M., Muizelaar, J.P., Okada, P., Beers,
S.R., Balasubramani, G.K., Hirtz, D. Comparison
of hypothermia and normothermia after severe
traumatic brain injury in children (Cool Kids): A
phase 3, randomised controlled trial. (2013) The
Lancet Neurology, 12 (6), pp. 546-553.
Adlbrecht, C., Huber, K., Reynolds, H.R., Carvalho,
A.C., Džavík, V., Steg, P.G., Liu, L., Marino, P.,
Pearte, C.A., Rankin, J.M., White, H.D., Lamas,
G.A., Hochman, J.S. Effects of timing, location
and definition of reinfarction on mortality in
patients with totally occluded infarct related
arteries late after myocardial infarction. (2014)
International Journal of Cardiology, 174 (1),
pp. 90 - 95.
Allegaert K., Anderson B., Simons S., van
Overmeire B. Paracetamol to induce closure of
the patent ductus arteriosis: another hype or is
it real? (2013) Arch Dis Child, 98, pp. 462-466.
Ady Wirawan, I.M., Larsen, P.D., Aldington, S.,
Griffiths, R.F., Ellis, C.J. Cardiovascular risk score
and cardiovascular events among airline pilots:
A case-control study. (2012) Aviation Space and
Environmental Medicine, 83 (5), pp. 465-471.
Allegaert K., Vanhaesebrouck S., Naulaers G.,
Anderson B.J. The paracetamol concentrationeffect relation in neonates. (2013) Pediatr
Anesth, 23, pp. 45-50.
Ahmed, J., Smith, W.M., Ruygrok, P.N.,
Occleshaw, C. Right ventricular morphology
on catheter angiography: Variations and its
implications for the diagnosis of arrhythmogenic
right ventricular cardiomyopathy. (2012) Heart
Lung and Circulation, 21 (11), pp. 700-705.
Aikman, K.L., Hobbs, M.R., Ticehurst, R.,
Karmakar, G.C., Wilsher, M.L., Thomas, M.G.
Compliance with guidelines for antimicrobial
therapy for community acquired pneumonia, at
Auckland Hospital, New Zealand. (2013) Journal
of Pharmacy Practice and Research, 43 (4),
pp. 272-275
Alagna, L., Park, L.P., Nicholson, B.P., Keiger, A.J.,
Strahilevitz, J., Morris, A., Wray, D., Gordon, D.,
Delahaye, F., Edathodu, J., Miró, J.M., FernándezHidalgo, N., Nacinovich, F.M., Shahid, R., Woods,
C.W., Joyce, M.J., Sexton, D.J., Chu, V.H. Repeat
endocarditis: Analysis of risk factors based on
the International collaboration on endocarditis
- Prospective cohort study. (2014) Clinical
Microbiology and Infection, 20 (6), pp. 566 - 575.
Allegaert K, Olkkola KT, Owens KH, van de Velde
M, de Maat MM, Anderson BJ. Covariates of
intravenous paracetamol pharmacokinetics in
adults. (2014) BMC Anesthesiol, 14, p. 77.
Allen, S.J. Fluid therapy and outcome: Balance
is best. (2014) Journal of Extra-Corporeal
Technology, 46 ( 1 ), pp. 28 - 32.
Allen, S.J. Gastrointestinal complications and
cardiac surgery. (2014) Journal of ExtraCorporeal Technology, 46 (2) pp. 142 - 149.
Al-Murrani, A., Ashton, F., Aftimos, S., George,
A.M., Love, D.R. Amino-terminal microdeletion
within the CNTNAP2 gene associated with
variable expressivity of speech. (2012) Case
Reports in Genetics, 172408.
Alpert, J.S., Thygesen, K.A., White, H.D., Jaffe,
A.S. Diagnostic and therapeutic implications
of type 2 myocardial infarction: Review and
commentary. (2014) American Journal of
Medicine, 127 ( 2 ), pp. 105 - 108 .
Alsweiler, J.M., Harding, J.E., Bloomfield,
F.H. Tight glycemic control with insulin in
hyperglycemic preterm babies: a randomized
controlled trial. (2012) Pediatrics, 129,
pp. 639-647.
Alawami, M., Wasywich, C., Cicovic, A., Kenedi,
C. A systematic review of clozapine induced
cardiomyopathy. (2014) International Journal of
Cardiology, 176 (2), pp. 315 - 320.
Alsweiler, J.M., Harding, J.E., Bloomfield, F.H.
Neonatal hyperglycaemia increases mortality
and morbidity in preterm lambs. (2013)
Neonatology, 103, pp. 83-90.
Albert, B.B., Eckersley, L.G., Skinner, J.R.,
Jefferies, C. QT prolongation in a child with
thyroid storm. (2014) BMJ Case Reports.
Ameratunga, R. Gluteal subcutaneous atrophy
after depot steroid injection for allergic rhinitis.
(2012) World Allergy Organ J, 5 (11), pp.168-169.
Alherbish, A., Westerhout, C.M., Fu, Y., White,
H.D., Granger, C.B., Wagner, G., Armstrong,
P. The Forgotten Lead: Does aVR ST-deviation
add insight into the outcomes of ST-elevation
myocardial infarction patients? (2013) American
Heart Journal, 166(2), pp. 333-339.
Ameratunga R, Brewerton M, Slade C, Jordan
A, Gillis D, Steele R, Koopmans W, Woon ST.
Comparison of diagnostic criteria for common
variable immunodeficiency disorder. (2014)
Front Immunol, 5, p. 415.
Alkindi, S., Battin, M., Aftimos, S., Purvis, D. Focal
dermal hypoplasia due to a novel mutation in a
boy with klinefelter syndrome. (2013) Pediatric
Dermatology, 30 (4), pp. 476-479.
Ameratunga, R., Casey, P., Parry, S., Kenedi, C.
Hypogammaglobulinemia factitia- Munchausen
syndrome masquerading as common variable
immune deficiency. (2013) Allergy Asthma Clin
Immunol, 9 (1), p. 36.
71
Ameratunga R, Chen CJ, Koopmans W, Dunbar
PR, Brewerton M, Lloydd R, Mansell CJ, van
Vliet C, Woon ST. Identification of germinal
centres in the lymph node of a patient with
hyperimmunoglobulin M syndrome associated
with congenital rubella. (2014) J Clin Immunol.,
34 (7), pp. 796-803.
Ameratunga R, Crooks C, Simmons G, Woon ST.
Health risks and adverse reactions to functional
foods. (2014) Crit Rev Food Sci Nutr, Aug 27.
Ameratunga, R., Lindsay, K., Woon, S.-T., Jordan,
A., Anderson, N. E. and Koopmans, W. (2014),
New diagnostic criteria could distinguish
common variable immunodeficiency disorder
from anticonvulsant-induced hypogammaglobulinemia. (2014) Clinical and Experimental
Neuroimmunology, doi: 10.1111/cen3.12135.
Ameratunga, R., Randall, N., Dalziel, S.,
Anderson, B.J. Samter’s triad in childhood: A
warning for those prescribing NSAIDs. (2013)
Paediatric Anaesthesia, 23 (8), pp. 757-759.
Ameratunga, R., Woon, S.T., Gillis, D., Koopmans,
W., Steele, R. New diagnostic criteria for
common variable immune deficiency (CVID),
which may assist with decisions to treat with
intravenous or subcutaneous immunoglobulin.
(2013) Clin Exp Immunol, 174 (2), pp. 203-211.
Ameratunga, R., Woon, S.T., Gillis, D., Koopmans,
W., Steele, R. New diagnostic criteria for
CVID. (2014) Expert Rev Clin Immunol, 10 (2),
pp. 183-186.
Anand-Kumar, V., Kung, M., Painter, L., Broadbent,
E. Impact of organ transplantation in heart, lung
and liver recipients: Assessment of positive life
changes. (2014) Psychology and Health, 29 (6),
pp. 687 - 697.
Anderson, B.J. My child is unique; the
pharmacokinetics are universal. (2012) Pediatr
Anesth, 22, pp. 530-538.
Anderson, B.J. Pharmacology in the very young:
anaesthetic implications. (2012) Eur J Anaesth,
29 (6), pp. 261-270.
Anderson, B.J. Pharmacology of Pediatric TIVA.
(2013) Rev Colomb Anestesiol, 41, 205-214.
Anderson, B.J. Goodbye to needles. (2013) Arch
Dis Child, 98, pp. 718-719.
Anderson, B.J. Is it farewell to codeine? (2013)
Arch Dis Child, 98, pp. 986-988.
Anderson, B.J., Dare, T. We need to confirm, not
relearn old information. (2014) Pediatr Anesth,
24, pp. 549-552.
Anderson, B.J., Holford, N.H.G. Understanding
dosing: children are small adults, neonates are
immature children. (2013) Arch Dis Child, 98,
pp. 732-736.
72
Anderson, B.J., McLay, J., Allegaert, K., Engelhardt,
T. Do old pharmacokinetic parameter estimates
predict new data? (2012) Br J Anaesth, 109 (6),
pp. 1013-1014.
Anderson, B.J., van den Anker, J.N. Why is
there no morphine concentration-response
curve for acute pain? (2014) Pediatr Anesth, 24,
pp. 233-238.
Anderson, N.H., Sadler, L.C., Stewart, A.W., Fyfe,
E.M., McCowan, L.M.E. Independent risk factors
for infants who are small for gestational age by
customised birthweight centiles in a multi-ethnic
New Zealand population (2013) Australian
and New Zealand Journal of Obstetrics and
Gynaecology, 53 (2), pp. 136-142.
E.M., McCowan, L.M.E. Ethnicity and risk of
caesarean section in a term, nulliparous New
Zealand obstetric cohort. (2013) Australian
Gynaecology, 53 (3), pp. 258-264.
E.M., McCowan, L.M.E. Ethnicity, body mass
index and risk of pre-eclampsia in a multiethnic
New Zealand population. (2012) Australian
Gynaecology, 52 (6), pp. 552-558.
Anderson, N.H., Sadler, L.C., Stewart, A.W.,
McCowan, L.M.E. Maternal and pathological
pregnancy characteristics in customised birthweight centiles and identification of at-risk smallfor-gestational-age infants: A retrospective
cohort study. (2012) BJOG: An International
Journal of Obstetrics and Gynaecology, 119 (7),
pp. 848-856.
Andresen, J.H., Battin, M.R. Late preterm infants
and therapeutic hypothermia. (2012) Journal of
Paediatrics and Child Health, 48 (1), pp. 78-79.
Angeli, T.R., Du, P., Paskaranandavadivel, N.,
Janssen, P.W., Beyder, A., Lentle, R.G., et al.
The bioelectrical basis and validity of
gastrointestinal extracellular slow wave
recordings. (2013) The Journal of Physiology,
591 (Pt 18), pp. 4567-4579.
Angeli, T.R., O’Grady, G., Du, P., Paskaranandavadivel, N., Pullan, A.J., Bissett, I.P., et al.
Circumferential and functional re-entry of in vivo
slow-wave activity in the porcine small intestine.
(2013) Neurogastroenterology and Motility:
the official journal of the European Gastrointestinal Motility Society, 25 (5), e304-314.
Angeli, T.R., O’Grady, G., Paskaranandavadivel,
N., Erickson, J.C., Du, P., Pullan, A.J., et al. Experimental and Automated Analysis Techniques
for High-resolution Electrical Mapping of
Small Intestine Slow Wave Activity. (2013)
Neurogastroenterology and Motility: the
official journal of the European Gastrointestinal
Motility Society, 19(2), pp. 179-191.
Arrol, N., Farquhar, C., Masson, V., Stone, P.,
Sadler, L. Can we improve the prevention and
detection of congenital abnormalities? An audit
of early pregnancy care. (2013) New Zealand
Medical Journal, 126 (1380), pp. 46-56.
Arsov, T., Mullen, S.A., Damiano, J.A., Lawrence,
K.M., Huh, L.L., Nolan, M., Young, H., Thouin,
A., Dahl, H.-H.M., Berkovic, S.F., Crompton,
D.E., Sadleir, L.G., Scheffer, I.E. Early onset
absence epilepsy: 1 in 10 cases is caused by
GLUT1 deficiency. (2012) Epilepsia, 53 (12),
pp. e204-e207.
Artrip, J.H., Rumball, E.M., Finucane, K. Repair
of left atrioventricular valve cleft defects with
patch augmentation. (2012) Annals of Thoracic
Surgery, 93 (6), pp. 2081-2083.
Atkinson HC, Stanescu I, Anderson BJ. Increased
phenylephrine plasma concentrations when
given in combination with acetaminophen.
(2014) New England Journal of Medicine, 370,
pp. 1171-1172.
Austin, D.M., Sadler, L., McLintock, C., McArthur,
C., Masson, V., Farquhar, C., Rhodes, S. Early
detection of severe maternal morbidity: A
retrospective assessment of the role of an
Early Warning Score System. (2014) Australian
Gynaecology, 54 (2), pp. 152 - 155.
Awori, M.N., Leong, W., Artrip, J.H., O’Donnell, C.
Tetralogy of fallot repair: Optimal z-score use for
transannular patch insertion. (2013) European
Journal of Cardio-thoracic Surgery, 43 (3), art.
no. ezs372, pp. 483-486.
Ayyavoo, A., Derraik, J.G.B., Cutfield, W.S.,
Hofman, P.L. Elimination of pain and improvement of exercise capacity in camurati-engelmann
disease with losartan. (2014) Journal of Clinical
Endocrinology and Metabolism, 99 (11),
pp. 3978 - 3982.
Ayyavoo, A., Derraik, J.G.B., Hofman, P.L., Biggs,
J. Bloomfield, F.H., Cormack, B.E., Stone, P.,
Cutfield, W.S. Severe Hyperemesis Gravidarum
is associated with Reduced Insulin Sensitivity
in the Offspring in Childhood. (2013) Journal
of Clinical Endocrinology And Metabolism,
Doi:10.1210/Jc.2013-2043.
Ayyavoo, A., Derraik, J.G.B., Hofman, P.L.,
Mathai, S., Biggs, J., Stone, P., Sadler, L., Cutfield,
W.S. Pre-Pubertal Children Born Post-Term Have
Reduced Insulin Sensitivity and Other Markers of
the Metabolic Syndrome. (2013) PLoS ONE, 8 (7),
art. no. e67966.
Azam, A., Cutfield, W., Mouat, F., Hofman, P.L.,
Jefferies, C., Webster, D., Gunn, A.J. Missed
congenital hypothyroidism in an identical twin.
(2012) Journal of Paediatrics and Child Health,
48 (10), pp. 936-938.
E Babl, F., Dalton, S., Cheng, N., Jay, G., Keijers, G.,
Lee, M., Neutze, J., Craig, S., Herd, D., Borland,
M., Phillips, N., Babl, F., Dalziel, S., Krieser, D.,
Rao, A., Schutz, J. Management of children with
possible appendicitis: A survey of emergency
physicians in Australia and New Zealand. (2014)
EMA - Emergency Medicine Australasia, 26 (5),
pp. 481 - 486.
Babl, F.E., Krieser, D., Oakley, E., Dalziel, S. A
platform for paediatric acute care research.
(2014) EMA - Emergency Medicine Australasia,
26 (5), pp. 419 - 422.
Bach, K.P., Kuschel, C.A., Hooper, S.B., Bertram,
J., McKnight, S., Peachey, S.E., Zahra, V.A.,
Flecknoe, S.J., Oliver, M.H., Wallace, M.J.,
Bloomfield, F.H. High bias gas flows increase lung
injury in the ventilated preterm lamb. (2012)
PLoS One, 7 (10), e47044.
Bahit, M.C., Lopes, R.D., Clare, R.M., Newby,
L.K., Pieper, K.S., Van de Werf, F., Armstrong,
P.W., Mahaffey, K.W., Harrington, R.A., Diaz, R.,
Ohman, E.M., White, H.D., James, S., Granger,
C.B. Heart failure complicating non-st-segment
elevation acute coronary syndrome: Timing,
predictors, and clinical outcomes. (2013) JACC:
Heart Failure, 1 (3), pp. 223-229.
Baker, P.A., Fernandez, T.M.A., Hamaekers, A.E.,
Thompson, J.M.D. Parker Flex-Tip or standard
tracheal tube for percutaneous emergency
airway access? (2013) Acta Anaesthesiologica
Scandinavica, 57 (2), pp. 165-170.
Baker, P.A., Moore, C.L., Hopley, L., Herzer,
K.R., Mark, L.J. How do anaesthetists in New
Zealand disseminate critical airway information?
(2013) Anaesthesia and Intensive Care, 41 (3),
pp. 334-341.
Baker, P.A., Raos, A.S., Thompson, J.M.D., Jacobs,
R.J. Visual acuity during direct laryngoscopy at
different illuminance levels. (2013) Anesthesia
and Analgesia, 116 (2), pp. 343-350.
Baker, P., Webber, J. Should supraglottic airway
devices be used by lifeguards at all? (2014)
Anaesthesia, 69 (8), pp. 928 - 929.
Baker, R.I., Harper, P., McLintock, C. Avoiding
adverse events with dabigatran by careful
selection of eligible patients. (2012) Medical
Journal of Australia, 196 (7), pp. 431-432.
Ball, D., Fisher, R., Burmeister, B., Poulsen, M.,
Graham, P., Penniment, M., Vinod, S., Krawitz, H.,
Joseph, D., Wheeler, G., McClure, B. The complex
relationship between lung tumor volume and
survival in patients with non-small cell lung
cancer treated by definitive radiotherapy: a
prospective, observational prognostic factor
study of the Trans-Tasman Radiation Oncology
Group (TROG 99.05). (2013) Radiotherapy and
Oncology, 106 (2013), pp. 305–311.
Baraliokos, X., McQueen, F.M., Suppiah, R.,
Braun, J. Quantification of bone marrow edema
by using magnetic resonance imaging for the
assessment of neck pain only marginally reflects
clinical evaluation in patients with rheumatoid
arthritis and ankylosing spondylitis. (2013) Ann
Rheum Dis, 72, p. 611.
Barber, C., Ille, S., Vergison, A., Coates, H. Acute
otitis media in young children - What do parents
say? (2014) International Journal of Pediatric
Otorhinolaryngology, 78 (2), pp. 300 - 306.
Barber, P.A., Pridmore, H.M., Krishnamurthy, V.,
Roberts, S., Spriggs, D.A., Carter, K.N., Anderson,
N.E. Cannabis, ischemic stroke and transient
ischemic attack: a case-control study. (2013)
Stroke, 44 (8), pp. 2327-2329.
Barrett, H.L., Gatford, K.L., Houda, C.M., De
Blasio, M.J., Mcintyre, H.D., Callaway, L.K.,
Nitert, M.D., Coat, S., Owens, J.A., Hague, W.M.,
Rowan, J.A. Maternal and neonatal circulating
markers of metabolic and cardiovascular risk in
the metformin in gestational diabetes (mig) trial.
(2013) Diabetes Care, 36 (3), pp. 529-536.
Barrett, H.L., Nitert, M.D., Jones, L., O’Rourke,
P., Lust, K., Gatford, K.L., De Blasio, M.J., Coat,
S., Owens, J.A., Hague, W.M., McIntyre, H.D.,
Callaway, L., Rowan, J. Determinants of maternal
triglycerides in women with gestational diabetes
mellitus in the metformin in gestational diabetes
(MiG) study. (2013) Diabetes Care, 36 (7),
pp. 1941-1946.
Bartley, J., Garrett, J., Grant, C.C., Camargo
Jr., C.A. Could vitamin D have a potential
anti-inflammatory and anti-infective role in
bronchiectasis? (2013) Current Infectious
Disease Reports, 15 (2), pp. 148-157.
Baker, R.A., Merry, A.F. Cell salvage is beneficial
for all cardiac surgical patients: Arguments for
and against. (2012) Journal of Extra-Corporeal
Technology, 44 (1), pp. p38-p41.
Batchelor, W.B., Ellis, S.G., Ormiston, J.A.,
Stone, G.W., Joshi, A.A., Wang, H., Underwood,
P.L. Racial differences in long-term outcomes
after percutaneous coronary intervention
with paclitaxel-eluting coronary stents. (2012)
Journal of Interventional Cardiology, 18,
pp. 1540-8183.
Baker, R.A., Newland Richard F., R.F., Fenton,
C., McDonald, M., Willcox, T.W., Merry,
A.F. Developing a benchmarking process in
perfusion: A report of the perfusion downunder
collaboration. (2012) Journal of Extra-Corporeal
Technology, 44 (1), pp. 26-33.
Batorelli AL, Andreini D, Pontone G, Trabattoni
D, Ferrari C, Mushtaq S, Ormiston JA. Stent
longitudinal distortion: strut separation
(pseudo-fracture) and strut compression
(“concertina” effect). (2012) EuroIntervention,
8, pp. 290-291.
Battin, M., Bevan, C., Harding, J. Growth in
the neonatal period after repeat courses
of antenatal corticosteroids: Data from the
ACTORDS randomised trial. (2012) Archives
of Disease in Childhood: Fetal and Neonatal
Edition, 97 (2), pp. F99-F105.
Battin, M.R., Knight, D.B., Kuschel, C.A.,
Howie, R.N. Improvement in mortality of very
low birthweight infants and the changing
pattern of neonatal mortality: The 50-year
experience of one perinatal centre. (2012)
Journal of Paediatrics and Child Health, 48 (7),
pp. 596-599.
Bean, D.J., Johnson, M.H., Kydd, R.R.
Relationships between psychological factors,
pain, and disability in complex regional pain
syndrome and low back pain. (2014) Clinical
Journal of Pain, 30 (8), pp. 647 - 653.
Bean, D.J., Johnson, M.H., Kydd, R.R. The
outcome of complex regional pain syndrome
type 1: A systematic review. (2014) Journal of
Pain, 15 (7), pp. 677 - 690.
Beatty, P.A., Laking, G. Clinical cancer advances
2012 and neoadjuvant chemoradiotherapy
in
operable
gastroesophageal
cancers.
(2013) Journal of Clinical Oncology, 31 (21),
pp. 2751 - 2752.
Beca, J., Gunn, J.K., Coleman, L., Hope, A.,
Reed, P.W., Hunt, R.W., Finucane, K., Brizard, C.,
Dance, B., Shekerdemian, L.S. New White matter
brain injury after infant heart surgery is
associated with diagnostic group and the use
of circulatory arrest. (2013) Circulation, 127 (9),
pp. 971-979.
Begum, G., Davies, A., Stevens, A., Oliver,
M.H., Jaquiery, A.L., Challis, J.R.G., Harding,
J.E., Bloomfield, F.H., White, A. Maternal
undernutrition programs tissue-specific epigenetic changes in the glucocorticoid receptor
in adult offspring. (2013) Endocrinology, 154,
pp. 4560-4569.
Begum, G., Stevens, A., Bolton Smith, E., Connor,
K.L., Challis, J.R.G., Bloomfield, F.H., White,
A. Epigenetic changes in fetal hypothalamic
energy regulating pathways are associated with
maternal undernutrition and twinning. (2012)
FASEB Journal, 26 (4), pp. 1694-1703.
Beliaev, A.M., Barber, P.A., Marshall, R.J.,
Civil, I. Denver screening protocol for blunt
cerebrovascular injury reduces the use of multidetector computed tomography angiography.
(2014) ANZ Journal of Surgery, 84 (6), pp. 429 432.
Beliaev, A.M., Civil, I. Asymptomatic carotid
blunt cerebrovascular injury: A new screening
criterion. (2014) ANZ Journal of Surgery, 84 (6),
pp. 491 - 492.
73
Beliaev, A.M., Civil, I. Multidetector CT
angiography influences the choice of treatment
for blunt carotid artery injury. (2014) BMJ Case
Reports, art. no. A1606.
Beliaev, A., Windsor, J., Smith, W.M. Mortality
risk stratification in severely anaemic Jehovah’s
Witness patients. (2012) Intern Med J,
42 (3), e1-3.
Bell, R., Pandanaboyana, S., Shah, N.,
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R.A., Steg, P.G., Ardissino, D., Armstrong, P.W.,
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Young, R.P., Hopkins, R.J., Hay, B.A. Joint Effect of
Single-Nucleotide Polymorphisms and Smoking
Exposure in Chronic Obstructive Pulmonary
Disease Risk. (2012) Am J Respir Cell Mol Biol,
185, p. 683.
Young, R.P., Hopkins, R.J. Statins and small
airways disease in COPD. (2012) Am J Respir Cell
Mol Biol.
Young, R.P., Hopkins, R.J. A Clinical Practice
Guideline Update on the Diagnosis and
Management of Stable Chronic Obstructive
Pulmonary Disease (comment). (2012) Ann Int
Med, 156 (1), pp. 68-69.
Young, R.P., Hopkins, R.J. CT screening for lung
cancer. (2012) Thorax, 67 (7), pp. 650-651
Young, R.P., Hopkins, R.J. Diagnosing COPD
and targeted lung cancer screening. (2012) Eur
Respir J, 40, pp. 1063-1064.
Young, R.P., Hopkins, R.J. Genetic susceptibility
testing to lung cancer and outcomes for smokers.
(2012) Tobacco Control (online), July 17.
Young, R.P., Hopkins, R.J. Increasing smokers’ risk
perception improves CT screening participation.
(2012) Thorax, 67 (9), pp. 834-835.
Young, R.P., Hopkins, R.J. Screening with
Low-dose Computed Tomography: Response
to the American Association of Thoracic
Surgery Guidelines. (2012) The Journal of
Thoracic and Cardiovascular Surgery, (http://
dx.org/10.1016/j.jtcvs.2012.08.074).
Young, R.P., Hopkins, R.J., Gamble, G.D. Clinical
applications of gene-based risk prediction for
lung cancer and the central role of chronic
obstructive pulmonary disease. (2012) Frontiers
in Genetics, 3 (Article 210), pp. 1-7.
108
Young, R.P., Hopkins, R.J. Genetic Variation in
Innate Immunity and Inflammation Pathways
Associated with Lung Cancer Risk. (2013) Cancer
2013; 119 (9), p. 1761. (online 2012; December
24,doi:10.1002/cncr.27953).
Young, R.P., Hopkins, R.J. Genetic risk in
Childhood Obesity: Implications for clinical
Practice. (2013) JAMA Pediatr, 167 (2),
pp. 196-197.
Young, R.P., Hopkins, R.J. Estimating
Overdiagnosis of Lung Cancer. (2013) Ann Int
Med, 158 (8), pp. 635-636.
Younossi, Z.M., Stepanova, M., Henry, L.,
Gane, E., Jacobson, I.M., Lawitz, E., Nelson,
D., Gerber, L., Nader, F., Hunt, S. Effects of
Sofosbuvir-Based Treatment, With and Without
Interferon, on Outcome and Productivity of
Patients With Chronic Hepatitis C. (2014) Clinical
Gastroenterology and Hepatology, 12 (8), pp.
1349 - 1359.e13.
Younossi, Z.M., Stepanova, M., Nader, F.,
Jacobson, I.M., Gane, E., Nelson, D., Lawitz, E.,
Hunt, S.L. Patient-reported outcomes in chronic
hepatitis C patients with cirrhosis treated
with sofosbuvir-containing regimens. (2014)
Hepatology, 59 (6), pp. 2161 - 2169.
Young, R.P., Hopkins, R.J. Is 20% of a Loaf
Enough? (2013) Cancer 2013, 119 (15), p. 2815.
Yu, T.-C., Hamill, J.K., Liley, A., Hill, A.G. Warm,
humidified carbon dioxide gas insufflation for
laparoscopic appendicectomy in children: A
double-blinded randomized controlled trial.
(2013) Annals of Surgery, 257 (1), pp. 44-53.
Young, R.P., Hopkins, R.J. Statins reduce lung
inflammation by promoting the clearance of
particulate matter from lung tissue. (2013)
Chest, 144 (1), July. DOI:10.1378/chest.13-0496.
Zargar, H., Addison, B., Mccall, J., Bartlett, A.,
Buckley, B., Rice, M. Renal artery embolization
prior to nephrectomy for locally advanced renal
cell carcinoma. (2014) ANZ Journal of Surgery,
84 (7-8 ), pp. 564 - 567.
Young, R.P., Hopkins, R.J. Statin Use in
Pneumonia. (2013) Am J Med, 126 (7), e12.
Young, R.P., Hopkins, R.J. Interleukin-6 and statin
therapy: potential role in the management
of COPD. (2013) Respiratory Research, 14,
pp. 74-75.
Young, R.P., Hopkins, R.J. Targeted CT image
screening and its effect on lung cancer detection
rate. (2013) Chest, 144 (4), pp. 1419-1420.
Young, R.P., Hopkins, R.J. Stage shift in computed
tomography screening: possible role of indolent
cancers, “Histology Shift”, and Overdiagnosis.
(2013) Am J Respir Crit Care Med, 188,
pp. 1034-1035.
Young, R.P., Hopkins, R.J. Update on the potential
role of statins in chronic obstructive pulmonary
disease and its co—morbidities. (2013) Expert
Rev. Respir. Med, 7 (5), pp. 533-544.
Young, S.W., Zhang, M., Freeman, J.T., MutuGrigg, J., Pavlou, P., Moore, G.A. The Mark
Coventry award: Higher tissue concentrations
of vancomycin with low-dose intraosseous
regional versus systemic prophylaxis in TKA:
A randomized trial knee. (2014) Clinical
Orthopaedics and Related Research, 472 (1),
pp. 57 - 65.
Zeng, I., Lumley, T., Ruggiero, K., Middleditch,
M., Woon, S.T., Stewart, R.A. Two optimization
strategies of multi-stage design in clinical
proteomic
studies.
(2013)
Statistical
Applications in Genetics and Molecular Biology,
12 (2), pp. 263-283.
Zeuzem, S., Soriano, S., Asselah, T., Bronowicki,
J.P., Lohse, A., Müllhaupt, M., Schuchmann, B.,
Bourlière, M., Buti, M., Roberts, S., Gane, E., et
al. Interferon-free Treatment with Faldaprevir
and BI 207127 for Genotype 1 HCV. (2013) New
England Journal of Medicine, 369, 630-639.
Zhang, S., Wilson, N.C., MacKey, A.H., Stott,
N.S. Radiological outcome of reconstructive hip
surgery in children with gross motor function
classification system IV and v cerebral palsy.
(2014) Journal of Pediatric Orthopaedics Part B,
23 (5), pp. 430 - 434.
Zhang, Y., Roxburgh, R., Huang, L., Parsons,
J., Davies, T.C. The effect of hydrotherapy
treatment on gait characteristics of hereditary
spastic paraparesis patients. (2014) Gait and
Posture, 39 (4), pp. 1074 - 1079.
Zwi, L.J., Yiu, T.S.Y., Marshall, M.R., Lam-Po-Tang,
M.K. Non-diabetic renal diseases in a multiethnic New Zealand cohort with type 2 diabetes
mellitus: Clinical and histopathological features.
(2014) Pathology, 46 (5), pp. 424 - 432.
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