2014 ADHB Research Report - Auckland District Health Board
Transcription
2014 ADHB Research Report - Auckland District Health Board
Annual Research Report 2014 Auckland District Health Board Welcome to the Auckland DHB Annual Research Report for 2014. Having an excellent programme of research distinguishes great hospitals. Auckland District Health Board – ADHB - is the largest tertiary care centre and the largest clinical research facility in New Zealand. Our research portfolio comprises over 1100 projects and our doctors, nurses, allied health professionals and scientists engage in research that attracts funding, participation and peer esteem both from New Zealand and internationally. ADHB’s hospitals are teaching hospitals and ADHB partners with the University of Auckland in an Academic Health Alliance. Its goals, to deliver research-informed healthcare alongside clinical teaching and training, will fast-track translation of research findings from “bench to bedside”, and onwards to communities and families. ADHB provides a first-class setting for research across the health spectrum. We serve a diverse population (with rapidly expanding migrant population) of over 400,000 as the local provider, and over 1.3 million as regional provider of specialist health services. Acute services are provided together under one roof so researchers can access participants under the care of skilled multidisciplinary teams of specialists with specialist equipment. ADHB’s accredited laboratory facility, LabPlus, provides a range of on-site laboratory services for clinical research, including diagnostic and genetic analysis, storage, disposal and shipping to central laboratories worldwide. Research at ADHB pays for itself – over 80 staff and a multitude of medical and laboratory procedures for research are paid for from external sponsorship, both commercial and charitable. The A+ Trust provides robust management of research monies, and interest earned on Trust funds is fed back into the organisation as a contestable research grants programme worth a half million dollars annually. ADHB is committed to preserving our status as a centre of clinical excellence by fostering our involvement in research activity, critiquing health care approaches and investigating new initiatives. We celebrate our contribution to health through research with our annual ADHB Research Excellence Award, Young Investigator Award, Best Research Posters and now the best summer students reports. Within the diversity, integral to all ADHB research is a desire by our committed staff to build a strong evidence base for our clinical, community and policy work, and ultimately, the good health and well-being of our patients. Welcome to the ADHB Annual Research Report for 2014. 1 2 Contents Annual Research Report 2014 Welcome to the Auckland DHB Annual Research Report for 2014 1 Introduction from the CMO 4 A word from the ADHB Research Office 5 Collaborations 8 Auckland Academic Health Alliance 9 SHIVERS 12 ADHB Research Excellence Awards 14 Current Research 17 Funding for Research 52 Promoting Research 63 Honours and Awards 66 Publications 70 Directory 109 3 Introduction from the CMO I am delighted to start this foreword by celebrating the fact that ADHB has over 1000 research projects registered with our research office. That is a sizeable portfolio of research activity and represents every type of research; quantitative and qualitative, small audit to multicentre randomised control trial, clinical and bench methods, student to experienced researcher led. This research activity translates into many publications and presentations to scientific and lay meetings, and some of those will be highlighted in this report. In order to support, and provide assurance, to our research community we have in this last year appointed a Clinical Lead Research, Dr Colin McArthur and established a Research Governance Committee comprising membership from the University of Auckland, the A+ Trust and the ADHB. This committee provides oversight for the activities of the Research Office and ensures that our research complies with necessary regulations, and that any issues relating to research are resolved. It also has an important strategic role and together with the University of Auckland, with whom we have a formal Academic Health Alliance, we hope to grow research even further. This year, for the first time, we have a new research funding opportunity courtesy of the University and the A+ Trust. The new Auckland Academic Alliance research grants aim to foster new and existing collaborations between our respective organisations, and from this opportunity we hope to see the emergence of more substantial grant applications to bodies such as the HRC. All of this activity does not happen without a lot of work behind the scenes and I would like to thank Mary-Anne Woodnorth and her team in the Research Office, Drs Colin McArthur and Kim Brackley who have ably chaired the Research Review Committee and of course all the members who have given up their time to read research applications. I also acknowledge the A+ Trust which hosts our research revenues and allows us to use the interest on research surpluses to fund new peer reviewed research activities, the A+ Trust grants. The Trust also sponsors summer students and this year the quality of research outputs was high with fierce competition for the Summer Student research prizes. Congratulations to Lydia Hingston supervised by Drs Ken Whyte and Kevin Ellyett. Thanks also to Prof Andrew Shelling and the University for hosting the awards ceremony. For new and aspiring researchers, I encourage you to continue to question, puzzle and formulate hypotheses - and then set about trying to answer the question, solve the puzzle or prove your hypothesis. If you want advice, come to the research office and we will try and help you get started. For those who are successful researchers already, congratulations on your publications and other achievements. Margaret Wilsher Chief Medical Officer and Head of Research Auckland District Health Board 4 A Word from the ADHB Research Office This document is a comprehensive report of the research activities that commenced at Auckland District Health Board in the years 2012 to 2014. During this period 904 new study protocols were approved and initiated. A total of 447 individuals, the majority ADHB staff members, took the lead role as site principal investigator for these new studies. Countless more were co-investigators, research nurses and co-ordinators, supervisors, mentors, clinical advisors or helpful hands. Considering the size and energy of the ADHB workforce participating in research it isn’t surprising that research activity spans the organisation and extends beyond it, as evidenced by the breadth and quality of our external collaborations both nationally and internationally. In fact, ADHB has been experiencing something of a research boom, with each successive year in this reporting period having the highest number of new projects to commence on record. The new record set in 2014 is 327, which represents a 100% increase in volume since ADHB starting producing research reports in 2006 and leads me to ponder about what might be driving such a surge. Certainly a number of changes and new initiatives have been advantageous for health and clinical research in the last three years and are worth mentioning. New ADHB studies annually 350 300 250 200 150 100 2006 2007 2008 2009 2010 2011 2012 2013 2014 Firstly the reform of the Ministry of Health’s Health and Disability Ethics Committees (HDECs) in 2012 has been a significant driver to reduce research approval cycle times. Prior to July 2012 researchers were tied to their regional HDEC and the distribution of partcipating study sites was restricted to the HDEC’s catchment area. Large multi-centre studies were served by a lone, inefficient, multi-regional HDEC in Wellington. Application was by paper copy in duplicate with ink signatures. The new operating standard introduced in 2012 saw the number of committees reduced from eight to four, but all multi-regional. Applications are now submitted via a web-based electronic system and applicants have the option of submitting to their local HDEC or to fast track to the next available HDEC meeting. Once submitted, applications are guaranteed a decision within acceptable timeframes. Though complicated and sometimes clunky, the e-submission system was quickly mastered by ADHB research staff. Very low risk studies no longer require HDEC review and this has pushed ascertainment of minimal risk on to the research organisations themselves. Our research office has been ably supported by our Research Review Committee to develop good decision rules about supporting low risk studies and so such studies are now having a far more rapid approval process. Two crucial new research appointments were made at ADHB in 2013 and 2014. In 2013 Dr Helen Wihongi (Ngati Porou and Ngapuhi) became the first Māori advisor for research for two DHBs – Auckland and Waitemata. Being co-located in the ADHB research office two days a week has meant Dr Helen has been able to provide a pre-emptive cultural and Tikanga Māori advisory service for researchers developing their research plans. After a tough 2012 during which He Kamaka Oranga ADHB Māori Health team transitioned into He Kamaka Waiora, the ADHB-Waitemata Māori Health collaboration, ADHB was suffering from a shortage 5 of Māori research review. A quality improvement “Greenbelt” project run in parallel by our Research Office team and volunteers from various research groups and attempting to address our then lengthy research approval cycle time made the timely discovery that rework and faulty loops in our process were exacerbating the delays in getting approval. Arriving in her role to discover a large number of projects needing review and research staff desparate to obtain approvals to commence, Helen had to quickly acquire an understanding of the value offering of her role and deal with the backlog. With the learnings from our Greenbelt project we were able to eliminate the duplications and unnecessary work in our processes and prioritise review for those projects that needed it soonest. With the support of Naida Glavish and the Māori Research Committee Helen devised and implemented rational standards for Māori responsiveness relevant to the range of research that is carried out in our organisation. The other accomplishments of Dr Helen in the first years in her new role are really to be admired – she has been the leader of an initiative to standardise Māori research review for DHBs nationally which has resulted in the creation of a document “A Framework for Māori Review of Research in District Health Boards” which will soon be implemented. We acknowledge the financial support of the A+ Trust and the dedicated work of student researcher Shirley Simmonds, sponsor Naida Glavish, and co-supervisor Dr Tristram Ingham (Capital and Coast DHB) in the creation of this work. Naida Glavish and Helen have been successful in winning seed funding for research on the health benefits of karanga (powerful, ceremonial call of welcome by wāhine Māori) from the Health Research Council of New Zealand. Helen is also a leading light of the growing local community of those interested in establishing national best practice for tissue bio-banking in health research, with particular emphasis on indigenous ethics and bio-banking. I have no doubt Helen will continue to act as stimulus and support for Māori-centred research to happen at ADHB and that through the knowledge gained by investigation health inequalities for Māori will improve. Intensive care specialist Dr Colin McArthur, busy researcher, chair of the Australian and New Zealand Intensive Care Society Clinical Trials Group, and long time Research Review Committee member, was appointed as ADHB’s Clinical Advisor for research in 2014 in a 0.2 FTE role funded by the ADHB Charitable Trust (A+ Trust). ADHB was relatively late compared with other research DHBs to appoint a clinical advisor but the appointment had become a matter of some necessity by 2014 with the research boom in full swing and RRC’s core of volunteers stretched to unreasonable lengths to maintain good governance over research. Colin, stepping into the new role took over the leadership of RRC, allowing our steadfast chair Kim Brackley to finally stand down (as chair, not from the committee). It was immediately clear that having Colin meant having the option to supplement the traditional two stream approval pathway with a middle road that dealt with studies that were more than minimal risk but not high risk. Redirecting applications from RRC agendas means RRC are not so overburdened, the time consuming post meeting feedback transactions are obviated and fewer studies miss out on timely review due to full agendas. And this has not had to be achieved at the cost of clinical risk. Colin has also been instrumental in establishing the ADHB Research Governance Committee (RGC) which has taken over responsibility for research strategic direction, probity and safety as workload prevented RRC from exercising these roles. RGC has dealt with an amazing range of issues and questions in its young life, many emerging from our strategic alliance (Auckland Academic Health Alliance) with the University of Auckland, and others reflecting the complexity of our ethical and collaborative environments. Colin, being more often than not the one delegated to action the RGC’s queries and decisions, by dint of his senior position and his ringfenced research time has been effective in bringing a number of matters to resolution in a timeframe that would have been impossible prior to his appointment. I think Colin’s establishment as clinical advisor for research and Helen’s as Māori advisor for research are marks of ADHB’s maturity as a research organisation. I feel very fortunate to have such able partners and wonderful people to bounce ideas off. The emphasis placed in recent years by HRC on funding research at the coalface of the health system has allowed DHB researchers to be competitive against the the more academic researchers of the major universities. Both Colin McArthur and Stewart Dalziel (Children’s Emergency Department) have obtained substantial funding via the HRC’s Research for NZ Health Delivery funding stream. Bill Abbott (NZ Liver Transplant Unit) holds an HRC Research Partnerships for Health Delivery grant with his University of 6 Auckland and Hepatitis Foundation partners. ADHB researchers have won three of only six prestigious HRC Clinical Practitioner Fellowships (Stuart Dalziel, Peter Bergin – Neurology, and Ralph Stewart - Cardiology). Helen, Colin and I recently took advantage of an invitation from the Ministry of Health to join a discussion group on the strategic refresh of the HRC and provided our opinions about how the HRC could continue to support NZ’s health sector by investing in top quality research in DHBs. We look forward to finding out about how the refreshed HRC can continue to create an environment favourable to the research you do. We also look forward to our future with the University of Auckland as a joined up research organisation and how we can leverage the University’s scientific and technical expertise to add translational power to joint funding applications. 1073 904 1032 176 $22.6 million With this report we intend to showcase a range of outputs and achievements of ADHB staff and their research partners over the last three years. We count ADHB’s credentials as a research organisation in volumes, such as new projects approved, number of research publications and value of grants obtained. What we are not able to show you with this report particularly well, and what we hope to be able to improve on in coming years, are the stories about how research has changed DHB practice, clinically, socially or organisationally, for the better. We are starting to be able to find out more about the real impact of research through the ADHB Research Excellence Award, but can do better. If your research project has created new knowledge that has enabled you to improve your service to our patients and community please tell us about it! I acknowledge everyone in our organisation that has supported me, educated me, cooperated with me, argued, struggled and fought with me, and ultimately enabled me and my team to provide your research with the ADHB seal of approval. Congratulations – I hope you enjoy this report. Mary-Anne Woodnorth Manager, Research Office Number of active research projects in 2014 New projects commencing in 2012-2014 Published research articles 2012-2014 Successful research grant applications involving ADHB 2012-2014 Value of research grants involving ADHB 2012-2014 7 Collaborations The Auckland Academic Health Alliance The Auckland DHB, in its many incarnations, has been in Grafton long before the medical school was established alongside it almost 50 years ago. Since then close clinical and research connections, forged by motivated individuals who saw the value in working together, have always been maintained. The foundations of the Auckland Academic Health Alliance – on a campus spanning both sides of Grafton Road, which we see evolving into an academic health campus, are testimony to the country’s highest, internationally ranked, university with a medical school ranked 43rd in the world and the country’s largest public hospital and clinical research facility. Both institutions have observed 21st century best practice abroad and have recognised a domestic need to make health sector returns that are greater than their collective parts. The Alliance model is focused on a virtuous cycle closely linking patients, research, teaching and education. This cycle sees patients involved in research, knowledge reaching patients faster and quicker pathways to commercialisation for research pioneered and developed by hospital and university researchers and clinicians. As two of the country’s largest institutions and certainly the two largest employers in our biggest city we have a single goal. This is to develop New Zealand’s version of a world-recognised leading tertiary and medical institution. These have been formed in the United Kingdom, Europe and the United States. They are internationally recognised, they are best practice, and they are the drivers of innovation and research for patients. Patient needs and health outcomes are met by the Centre. They are a hub for pioneering clinicians, hospital and university researchers. Put another way, they are a magnet for people working in the health sector. So why does New Zealand need an Academic Health Alliance and why should it be in Auckland? There is an array of reasons. We have world-recognised health researchers and clinicians here now who have collaborated. They have lit the pathway and achieved success without support. We see the Alliance as a multiplier – it will foster more collaborations –and more successes. Those collaborations and the nurture of the intersection at which research and clinical practice meet will draw health workers and it will keep them here. We have health issues specific to New Zealand that need New Zealand research and solutions. In Auckland we have the greatest density of population – patients are central to Alliance research. And we are in an age of increasing health sector costs, an ageing population and an acute awareness of the efficiencies and gains that can be achieved through collaboration. 8 The Auckland Academic Health Alliance was officially launched by the Minister of Health the Hon Tony Ryall on Friday 29 November 2013. The Auckland Academic Health Alliance is an exciting development. Its deliverables will be even more exciting. One of the first significant initiatives of the AAHA is the establishment of a co- funded (A+ Trust and Faculty of Medical and Health Sciences) research fund designed to support joint research projects. This is a visible indication of the importance that the University places on the role of AAHA in its future plans, and vice versa. It also provides a greater opportunity to develop collaborative translational research opportunities that should improve success in competitive research grants, such as the Health Research Council project and programme grants. 9 Newsflash – Auckland Academic Health Alliance hosts 2014 Summer Studentship Prize presentation Student researchers work at Auckland DHB during the summer months each year. These studentship projects are well regarded as being one of the best ways to utilise local talent to find out things Auckland DHB is interested in knowing, and for a very small investment. The A+ Trust supports Auckland DHB staff to devise projects which will answer important clinical question by funding stipends for student workers. Thirteen of these projects have been funded during 2012 to 2014. The scheme runs under the auspices of the AAHA, with the Faculty of Medical and Health Sciences administering the grants. The end of project reports prepared by the 2014 students were recently assessed for scientific quality by an expert panel. The winner and runner up of the 2014 A+ Trust Summer Studentship prize for best students’ reports were Lydia Hingston (winner) and Jade Lau Young (runner up). The prizes to Lydia and Jade were announced by Chief Medical Office Dr Margaret Wilsher at an AAHA event held at the University of Auckland Grafton Campus on May 14th. Congratulations to Lydia and Jade. Their winning project abstracts are below. 1. Blood pressure response to spirometry: determination of the arterial pressure response to the forced vital capacity manoeuvre in normal subjects and those with chronic obstructive pulmonary disease Lydia Hingston, supervised by Kevin Ellyett, Brooke Cantley and Ken Whyte, Greenlane Respiratory Clinic Spirometry lung function testing is a key diagnostic tool which aids in the treatment of many lung disorders. Spirometry requires a forced vital capacity (FVC) manoeuvre: a maximal inspiration, forced expiration and a final maximal inspiration. This manoeuvre may cause transient changes in systemic arterial blood pressure (SABP) (Ruppel, 2009). These SABP changes have not been quantified before, yet there are many contraindications for spirometry concerning the transient changes in blood pressure and adverse events, such as risk of aneurysm (Cooper, 2010). The aim of this study was to observe the changes in SABP with the use of a continuous non-invasive arterial blood pressure (CNBP) monitor during spirometry in both a normal group (n=20) and a chronic obstructive pulmonary disease group (COPD) (n=15). Results: Both groups demonstrated rapid increases in SABP during the forced expiration, and decreases in SABP during the final inspiration. The systolic pressure increased during the forced expiration by 31.0 mmHg in the COPD group and 27.7 mmHg in the control group. No significant differences in pressure changes were observed between the two groups. Conclusions: The fluctuations in SABP observed are likely to be less than fluctuations that occur when people perform Valsalva manoeuvres in their everyday lives, such as when defecating. These observed transient pressure changes in both the COPD and control groups were not large and are unlikely to cause an adverse cardiac, cardiovascular or ocular event. We now have quanfified the SABP changes in two groups and have a better understanding of the haemodynamic changes during spirometry. 10 2. The clinical utility of chest CT in chronic unexplained cough Jade Lau Young, supervised by Margaret Wilsher and John Kolbe, Respiratory Department, Auckland City Hospital Background and objectives: Cough is a common, distressing symptom and is the most common reason for presentation to a doctor. In those without satisfactory response to accepted guideline interventions, additional investigations (lung function and HRCT) are often performed to exclude less common pathologies. This study aimed to summarise the clinical picture of a patient with chronic cough in New Zealand. It also used lung function testing to reveal the presence of subtle pulmonary pathology in patients with chronic cough/ Lydia Hingston (left) and Jade Lau Young (right) with Margaret Wilsher at the AAHA prizegiving ceremony. Methods: Patients with chronic, unexplained cough were recruited retrospectively through the Green Lane Imaging Database. Patient demographics, cough symptom information, gastro-oesophageal reflux disease (GORD) and rhinosinusitis symptoms and lung function testing data were collected. Mann-Whitney tests, t-tests, sign tests and linear regression were performed using SPSS software. Results: Patients were 65% female, 92% Caucasian, with median BMI 27.6 (range 17.8-50.1) and median age 65 (15-82). 38% and 57% of patients reported GORD and rhinosinusitis symptoms respectively. When analysed as a group, patients had decreased, abnormal% Predicted FEV1 and FVC on lung function testing (p<0.001 and p=0.001 respectively) despite their lung function falling within normal limits when assessed individually. In this study an obese BMI was shown to have significant effect upon lung function and BMI was a predictor for %predicted FVC and FEV1/FVC, but not FEV1 (p=0.036, 0.036 and 0.267 respectively). Conclusion: This study validated existing ideas of the clinical picture of a patient with chronic cough. Despite appearing normal when assessed individually, patients had statistically significant abnormal lung function tests when analysed as a patient group. BMI was found to be an important factor in lung function performance, correlating negatively with %Predicted FVC and FEV1/FVC. 11 The SHIVERS study Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance SHIVERS is an international, multi-disciplinary and multi-agency collaboration to evaluate influenza disease burden, epidemiology, aetiology, risk factors and immunology, as well as measuring the effectiveness of prevention strategies such as influenza vaccination. This project is a result of a funding arrangement between the US Centre for Disease Control (CDC) and the New Zealand crown research institute Environmental Science and Research (CRI). It aims for better understanding the burden of influenza and how it is spread about the world. The original bid was successful in beating beat all other Southern Hemisphere applicants because of the collaborative potential offered by researchers at the ESR, Auckland DHB, Counties-Manukau DHB, the Universities of Auckland and Otago and Chicago’s St Jude Children’s research hospital. Lead investigators for Auckland DHB are paediatrician Cameron Grant, intensivist Colin McArthur and microbiologist Sally Roberts. A dedicated team of five research nurses at ADHB who work on this project year round. Besides the quality of researchers and their collaborative dynamic, the research team won because of some of the unique features of both our health system and geography. Here, public hospitals look after all acute admissions for SARI, giving us great integrity in our public health database. We also have a good track record in the early detection of pandemic viruses. Dr McArthur co-ordinated the national intensive care response to the influenza pandemic in 2009. The research shows how uniquely well placed a New Zealand team is to pursue these important objectives in international influenza patterns and risks. It has drawn a number of mini-conferences and international visitors to New Zealand, where CDC staff are now frequent visitors. SHIVERS is in its fourth year and the team looks forward to pursuing a set of objectives out onto 2016. Conclusions: The fluctuations in SABP observed are likely to be less than fluctuations that occur when people perform Valsalva manoeuvres in their everyday lives, such as when defecating. These observed transient pressure changes in both the COPD and control groups were not large and are unlikely to cause an adverse cardiac, cardiovascular or ocular event. We now have quanfified the SABP changes in two groups and have a better understanding of the haemodynamic changes during spirometry. 12 13 Auckland District Health Board Awards Auckland DHB Research Excellence Awards This award, offered annually in conjunction with ADHB Healthcare Excellence Awards, recognises lead authors of significant, original research papers published in the preceding year. Applications are judged by a panel of top researchers for contribution to new knowledge, potential to inform best practice, stakeholders and clinical decision making, and potential to improve healthcare delivery. 14 2012 Joint Winner 2012 Joint Winners Dr Deborah Williamson – Department of Clinical Microbiology, LabPlus, Auckland City Hospital, for her paper “Clinical failures associated with rpoB mutations in phenotypically occult multidrug-resistant Mycobacterium tuberculosis” (Int J Tuberc Lung Dis. 2012 Feb; 16(2):216-20. doi: 10.5588/ijtld.11.0178) Drs Bo Remenyi and Nigel Wilson – Paediatric and Congenital Cardiac Service, Starship Children’s Hospital, for their paper “World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease—an evidence-based guideline” (Nature Reviews Cardiology 9, 297-309 (May 2012) | doi:10.1038/nrcardio.2012.7) Dr Deborah Williamson and team. Dr Bo Remenyi and Nigel Wilson. Using molecular tests that detect mutations causing resistance to rifampicin, one of the main drugs used against Mycobacterium tuberculosis, the team found that some of these gene mutations were not detected by conventional methods. There was also a significant association between the presence of these mutations and tuberculosis treatment failure. Following this research, genotypic testing has been adopted as standard in the Clinical Microbiology Laboratory. This has allowed earlier detection and treatment of several cases of MDR-TB sooner than would have been using conventional susceptibility test results. The international rheumatic heart disease (RHD) standardisation project aims to support the effectiveness of screening as a strategy by establishing echocardiographic changes that are indisputably rheumatic heart disease. RHD is the most serious complication of acute rheumatic fever (ARF) and is a significant cause of mortality and morbidity in New Zealand with 800 admissions to hospitals and 200 deaths per year. Rates for Māori and Pacific Island peoples are among the highest in the world. Globally, RHD is the most common cause of acquired heart disease in children and young adults. Long-acting penicillin is effective to prevent mild RHD from progressing to severe disease thus avoiding cardiac surgery. Portable echocardiography allows detection of mild (often subclinical) RHD, but many different criteria have been used internationally. These findings also have international public health significance, as they suggest that the global prevalence of MDR-TB may be greater than is currently estimated. The standardised criteria aim to permit rapid and consistent identification of individuals with RHD without a clear history of acute rheumatic fever and reduce false positive diagnoses. They are evidence-based guidelines that are now being recommended as best practice. 15 2013 Winner 2014 Winner Dr Stuart Dalziel – Children’s Emergency Department, Starship Children’s Hospital, for his paper “Predictors of severe H1N1 infection in children presenting within Pediatric Emergency Research Networks (PERN): retrospective case-control study” (BMJ 2013;347:f4836). Dr Catherine Han – Medical Oncology, Regional Cancer and Blood Service, Auckland City Hospital, for her paper “Phase I drug-interaction study of effects of calcium and magnesium infusions on oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer patients” (BMC Cancer 2013, 13:495 doi:10.1186/1471-2407-13-495). Dr Stuart Dalziel and team. This study has identified six risk factors associated with severe outcomes in children presenting to emergency departments with influenza-like illness. The study identified 321 children with severe outcomes (including death or admission to intensive care) due to H1N1 infection at 79 sites in 12 countries, from a global consortium of paediatric emergency medicine networks during the first season of the H1N1 pandemic in 2009. Of these 265 (83 per cent) presented to emergency departments with Centres for Disease Control and Prevention defined symptoms of influenza-like illness and were matched with random and age-matched controls with influenza-like illness who did not have severe outcomes. The risk factors identified include two chronic disease factors (chronic lung disease, cerebral palsy/developmental delay) and four physiologic or physical examination factors including requirement for oxygen, tachycardia relative to age, signs of chest retractions and dehydration. The study is the largest international study of severe paediatric outcomes with H1N1. The data is applicable both in times of a pandemic and during routine influenza seasons. In addition to identifying the six risk factors, this study involved the establishment of a new research network – Paediatric Emergency Research Networks (PERN) comprised of representative hospitals from the five major paediatric emergency medicine research networks located in Europe, Middle East, North America (one each from Canada and USA) and Australasia – that has access to data from over three million paediatric emergency department presentations annually from more than 100 hospitals in four of the six World Health Organisation regions. 16 Dr Catherine Han and team. Dr Catherine Han undertook research within Auckland City Hospital’s medical oncology department, one of Australasia’s largest cancer treatment centres, to understand if calcium and magnesium infusions had any effect on reducing the debilitating neurotoxicity on patients caused by a commonly used chemotherapy drug, oxaliplatin. Oxaliplatin is regularly used for treating various forms of cancer, but often causes nerve damage that leads to the treatment being reduced in dose or stopped prematurely. Quality of life is reduced for cancer patients due to its side effects. The practice of giving calcium and magnesium infusions to counter the debilitating neurotoxicity of oxaliplatin is currently used by many oncologists worldwide. Dr Han and her team introduced a double-blind, placebo-controlled, cross-over study which evaluated the effectiveness of these infusions in cancer patients. The finding was that the calcium and magnesium gave no protective effects for the oxaliplatin-induced neurotoxicity. Based on the results of the study, the use of the infusions has been withdrawn from Auckland City Hospital’s Oncology Department. This has improved patient contact time, by significantly reducing the treatment time required by oncology nurses. The other key benefit is a large saving every year in health dollars across the department. Current Research ADHB researchers are instigators and leaders of projects in almost all clinical and support services of the organisation. Many participate in international, collaborative, multi-centre studies, and in commercially funded clinical trials of pharmaceuticals and medical devices. ADHB also provides essential resources and partner¬ships for researchers from other organisations. Below is presented a snapshot of the 904 new research projects that commenced at ADHB in 2012 through 2014, along with the lead investigator. 17 Allied Health – Audiology, Nutrition, Pharmacy, Shelley Myers - A comparaison of the effectiveness of tympanometry measures in Down’s Syndrome children Eamon Duffy - Anti-microbial usage point prevalence study Lydia O’Connor - Assessing babies’ speech development using the IMP (Infant Monitor of vocal Production) Physiotherapy, Social Work, Speech & Language: Eamon Duffy - Outpatient intravenous anti-microbial (OPIVA) treament and outcome review Alison Forbes - Clinical audit of compliance with Pharmac’s restrictions on hospital medicines list medicines Alison Forbes - Clinical audit of compliance with Pharmac’s restrictions on Hospital Medicines List medicines: infliximab Lynn Gillanders - Quality of care: experience of an adult HPN patient Meghann Grawburg - A quantitative investigation into thirdparty disability in family members of people with aphasia: The second phase of a mixed methods study Peter Huggard - A hidden jewel: social work in primary care practice in Aotearoa New Zealand Nicola Saywell - Gaining perspectives of people with stroke, to inform development of a group exercise programme David Welch - Cortical auditory evoked potentials in response to frequency-specific speech tokens measured in infants Anaesthesia: Adult, Cardiothoracic, National Women’s and ORL: Vanessa Beavis - International observational cohort study of complications following elective surgery Andrea Kelly - ‘The Self-Esteem of Children with Hearing Impairment Alan Broderick- A novel, non-invasive device for the estimation of stroke volume compared with the continuous thermodilution technique using a pulmonary artery catheter Eddie Kim - ADHB surgical VTE prophylaxis: second snapshot audit Alan Broderick - The use of bivalirudin in the management of unanticipated heparin resistance during cardiac surgery Helen Lo - A study of venous thromboembolic events in surgical patients at Auckland District Health Board Alan Broderick - Aorto-atrial fistula visualised using 3D transoesophageal echocardiography Sandra McLellan - Can dietitians reduce interdialytic weight gain in at risk haemodialysis patients through tailored education on dietary sodium intake? Douglas Campbell - NeuroVISION study- Neurological Impact of Vascular events In noncardiac Surgery Anna Miles - Airway responsiveness to aspiration of thin and thickened fluids and its relationship with clinical outcomes Anna Miles - Swallowing difficulties in people following cardiac surgery and lung transplant surgery Anna Miles - Patterns of swallowing impairment in a paediatric videofluouroscopic swallow study (VFSS) caseload 18 Suzanne Purdy - Perception of Speech Prosody in Children with Hearing Loss Grace Chang - Oxytocin infusion audit in association with elective Caesarian section David Cumin - Factors determining successful information transmission at patient handover: Information salience survey David Cumin - Mining intraoperative physiological data: interrogating the information that is routinely collected Daniel Devcich - A psychometric and pragmatic evaluation of a behaviourally anchored rating scale for measuring the use of the WHO Surgical Safety Checklist Matthew Drake - EROS: Enhanced Recovery in Obstetric Surgery- Effect of a new care pathway on patient outcomes Kerry English - Cancelling Elective Surgery: A Mixed Methods Study of the Impact on Quality of Life, Postoperative Outcomes and Patient’s Socioeconomic Standing Robert Fry - A retrospective survey of substance abuse in anaesthetists in Australia and New Zealand Setareh Ghahreman - Epidural response times at National Women’s Hospital: an audit of current practice Veronica Gin - Improving pre-operative anaesthesia information delivery and communication on Level 8 Anaesthesia via patient survey Kerry Gunn - The Massive Transfusion Registry Kerry Gunn - Retrospective audit for prevalence of Iron Deficient Anaemia at Auckland City Hospital Kerry Gunn - Retrospective audit to understand Blood Transfusion Rates for elective procedures in Adult Patients within Auckland City Hospital and Greenlane Clinical Centre Kathryn Hagen - Measurement of Exercise Tolerance for Surgery (METS) Study Jack Hill - Intrathecal morphine analgesia: outcome measures after caesarian section Jack Hill - Serial TEG® and corresponding Plasma Fibrinogen: A National Womens compliance audit Timothy Holliday - Comparison of Assessment of residual regurgitation following Mitral Valve Repair between the immediate post repair transesophageal echocardiogram and follow up transthoracic echocardiogram Nicola Hooper - Outcomes in Patients with Aortic Stenosis Undergoing Anaesthesia in Auckland City Hospital in 20092010 (or Outcomes in Aortic Stenosis Audit 2009-10) James Houghton - Ultrasound guided brachiocephalic vein cannulation; an audit of practice Kim Jamieson - Mastectomy pain audit: Retrospective audit of the incidence of persistent pain >6months post surgery for mastectomy patients Steven Kim - Preoperative ACE inhibitor and Angiotensin receptor antagonist Management Steven Kim - Preoperative Exercise Testing Study (Retrospective Observation) Beau Klaibert - A Review of Surgical Venous Thromboembolic Prophylaxis at Level 8 Operating Theaters at Auckland City Hospital Cornelis Kruger - Advance Targeted Transfusion in Anaemic Cardiac Surgical patients for Kidney Protection (ATTACK II: Feasibiltiy Chart Review) Cornelis Kruger - Blood Glucose during Cardiopulmonary Bypass Surgery: An Audit Pre & Post Standardisation of Cardioplegia Glucose Content Cornelis Kruger - Propofol vs. Etomidate: Is Etomidate Haemodynamically Superior for Induction of Patients Undergoing Cardiac Surgery: a randomised, controlled blinded trial. Neil MacLennan - Prognostic implications of elevated preoperative high-sensitivity Troponin T in vascular surgery patients Manisha Mistry - Propofol vs etomidate use in cardiac surgery; a retrospective audit of clinical databases: is there a difference in mortality? Mark Moll - Multidisciplinary audit of local anaesthesia use and knowledge of presentation and management of local anasethetic toxicity Mark Moll - Audit of practice and multidisciplinary knowledge of intrauterine resuscitation at National Women's Hospital, Level 9, Auckland City Hospital 19 Anaesthesia: continued Aurance Nkosinathi Mdladla - Audit of the usage of activated recombinant factor 7 (rFVIIa) on Level 4 theatres at Auckland City Hospital Felicity Pugh- Restrictive Versus Liberal Fluid Therapy in Major Abdominal Surgery Catherine Purdy- An Evaluation of the Stress Factors of Practicing Anaesthesia within New Zealand and Australia Jeffrey Reddy- The incidence of rocuronium related anaphylaxis in Auckland Jonathan Wallace – Retrospective opioid audit Guy Warman- Light treatment for sleep and circadian disruption in kidney donor patients Jennifer Weller - Evaluating the multidisciplinary operating room simulation training course Glyn Richards- Retrospective audit of maternity patients receiving mexiletine during pregnancy for neuropathic pain Jennifer Weller - Review of patient notes for surgical complications to evaluate the effectiveness of an educational intervention aimed at improving interdisciplinary communication in the operating room Neil Robertson- Adult perioperative fluid therapy audit Daniel Wood - Fraction Inspired Oxygen Survey Tim Short- Pharmacokinetic-Pharmacodynamic modelling of Sevoflurane: Single centred prospective unblinded descriptive study Anaesthesia (Starship): Michelle Soakell-Ho- Improving Informed Consent in Anaesthesia with IT Mediated Risk Disclosure in the Preoperative Period Michelle Soakell-Ho- The Auckland Review of Surgical Outcomes Study (TAuRoS): a single centre, retrospective cohort study of postoperative outcomes for patients undergoing non-cardiac surgery Paul Baker - An educational evaluation of the Orsim bronchoscopy simulator to differentiate between groups of anaesthetists with different levels of bronchoscopy experience Sue Pickup - A retrospective audit of paediatrics attending the complex pain clinic at Starship Lena Tan – Perioperative anaesthetic assessment Martin Steynor - Antacid prophylaxus in obstetrics: an audit of current practice Wei Chung Tong- Prospective randomized single blind control trial of Catheter assisted nasotracheal intubation in children to minimize nasopharyngeal trauma Ghassan Talab - Retrospective observational study of postoperative temperatures in elective cardiac surgery patients at Auckland City Hospital Wei Chung Tong - Does using Ligasure reduce seroma rates in SLNB, and node dissection (ALND and GD)? Andrew vander Poll - Database for perioperative risk associated with aortic stenosis (AS) in non-cardiac surgery Joreline van der Westhuizen - Retrospective audit of activation of Massive Transfusion Protocol for large obstetric bleeds Joreline van der Westhuizen - Retrospective audit of perioperative management of diabetic patients 20 Yvonne Wagner- Anaesthesia outcomes in the morbidly obese obstetric patient Cardiology (Adult): Angela Barnes - Pacific Best Practice Cardiac Rehabilitation Project Jocelyne Benatar - A Multicenter, Randomized, DoubleBlind, Placebo-Controlled, Phase 3 Study to Evaluate Cardiovascular Outcomes of TAK-875, 50 mg in Addition to Standard of Care in Subjects with Type 2 Diabetes Jocelyne Benatar - A Phase III, multicentre, international, randomised, parallel group, double blind cardiovascular safety study of BI 10773 (10 mg and 25 mg administered orally once daily) compared to usual care in type 2 diabetes mellitus Jocelyne Benatar - Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition with Evacetrapib in Patients At a High-Risk for Vascular Outcomes Jocelyne Benatar- A Randomized, Double-Blind, PlaceboControlled, Multicenter Study to Assess Cardiovascular Outcomes Following Treatment with MK-3102 in Subjects with Type 2 Diabetes Mellitus: OMNEON Jocelyne Benatar- Trans fatty acid analysis in vegans Jocelyne Benatar - A Randomized, Double-blind, Placebocontrolled, Parallel-group Study to Evaluate the Effect of Long-term Treatment with BELVIQ (lorcaserin HC1) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects with Cardiovascular Disease or Multiple Cardiovascular Risk Factors Robert Doughty- Protocol GC28210. A phase II, randomised, placebo controlled, double-blind study of the safety and efficacy of MPSK3169A in patients with coronary heart disease or high risk of coronary heart disease Robert Doughty- Renal Denervation for Heart Failure with Preserved Ejection Fraction Robert Doughty- REDUC LAP-HF (A Study to evaluate the DC Devices Inc IASD System II to REDUCe Elevated Left Atrial Pressure in patients with Heart Failure) Roberty Doughty - A Randomized, Double Blind, Placebo Controlled, Parallel Group Study Evaluating the Efficacy and Safety of Alirocumab in Patients with Primary Hypercholesterolemia not treated with a statin Robert Doughty - A randomised, controlled trial to determine whether intensive behavioural and medical management and/or renal denervation will reduce blood pressure in real-world patients with resistant hypertension, and whether the two approaches achieve a similar benefit Elizabeth Broadbent - Improving patients’ understanding of their heart condition through the use of drawings of the heart Robert Doughty - The Imperative- HF trial (Intensified Management using PERidishArge Biomarker Testing and InterVention in cute heart failure). RCT comparing peridischarge management of acute decompensated heart failure (ADHF) with usual clinical care Arthur Coverdale - Acute myocarditis: our experience at Auckland City Hospital 2003-2012 Chris Ellis- Australian and New Zealand Cardiac Society Acute Coronary Syndrome Audit: ANZ Snapshot 2012 Arthur Coverdale- Retrospective Chart Review of Percutaneous Mitral Valvuloplasty in Pregnancy Jane Hannah- The use of continuous subcutaneous frusemide in decompensated heart failure: can it achieve a diuresis? Brett Cowan- Multicenter open-label study to evaluate efficacy of gadobutrol-enhanced cardiac magnetic resonance imaging (CMRI) for detection of significant coronary artery disease (CAD) in subjects with known or suspected CAD by a blinded image analysi Paul Davis - Paramedic Initiated Helivac to Tertiary Hospital for Primary Percutaneous Coronary Intervention: A new Approach in the Management of ST-Elevation Myocardial Infarction Patients Margaret Hood - A Usability Study of the MoMe Continuous ECG Monitoring and Arrhythmia Detection System Kerryanne Johnson - Repeat balloon aortic valvuloplasty and its role in the TAVI era Nigel Lever - Cardiac Resynchronisation therapy (CRT) and A-V Node ablation in AtrialFibrillation 21 Cardiology (Adult): continued Nigel Lever - PROTECT-ICD Trial: Programmed Ventricular Stimulation to Risk Stratify for Early CardioverterDefibrillator (ICD) Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction Shyam Sankaran - Cardiac MRI at Auckland City Hospital: Experience from 2003-2012 Boris Lowe- Retrospective review of cardiac MRI diagnoses for investigation of elevated troponin in angiographically normal coronary arteries Gnalini Sathananthan - Assessment of right ventricular volumes over time in patients following atrial switch repair Ralph Maddison - REMOTE-CR: Remote Exercise Monitoring Trial for Exercise-based Cardiac Rehabilitation Janarthanan Sathananthan- Risk assessment and outcomes in patients >80years old undergoing isolated aortic valve replacement Steph Madenholt-Titley - Retrospective observational elective cardioversion audit Chris Occleshaw - Audit in the use of cardiac CT scanning in children with congenital heart disease in ADHB 2010-2013 John Ormiston- NG PROMUS A Prospective, Multicenter Trial to Assess the NG PROMUS EverolimusEluting Platinum Chromium Coronary Stent System (NG PROMUS Stent System) for the Treatment of Atherosclerotic Lesion(s) Janarthanan Sathananthan- Coronary artery bypass grafting in asymptomatic dialysis patients prior to renal transplantation Warren Smith- Is the benefit/risk ratio for cardiac defibrillators implanted in older populations (age 75) still favourable? Protocol, v#1, 15/3/12 Warren Smith - Sternal ECG Patch Comparison Trial Cathrine Patten - Evaluating the Rate of Undiagnosed Type 2 Diabetes in Patients Referred for Outpatient Coronary Angiograms (ERUPT) Ralph Stewart- Evaluation of a point score for assigning surgical priority for patients with severe heart valve disease at Auckland District Health Board James Pemberton - Retrospective study of infective endocarditis at Auckland City Hospital 2005-2011 Ralph Stewart- A Randomized, DoubleBlind, Placebo Controlled, ParallelGroup Study to evaluate the effect of SAR236553/REGN727 on the occurrence of cardiovascular events in patients who have recently experienced an Acute Coronary Syndrome James Pemberton- Retrospective study of Trastuzumab induced cardiotoxicity at Auckland City Hospital Peter Ruygrok- A randomized, controlled study to evaluate the safety and cardiovascular effects of Algisyl-LVR™ as a method of left ventricular augmentation in patients with dilated cardiomyopathy (AUGMENT-HF) Peter Ruygrok- Effectiveness of previously cannulated radial arteries as conduits for coronary artery bypass surgery Peter Ruygrok - Outcome following heart transplantation in Maori and Pacific Island patients: a comparison with European New Zealanders Peter Ruygrok – The AVERT Trial 22 Peter Ruygrok - Confocal laser scanning microscopy for assessment of cardiac allograft rejection Ralph Stewart - Prevention of Serious Adverse Events following Angiography: A department of Veteran Affairs Cooperative Study Ralph Stewart - International study of comparative health effectiveness with medical and invasive approaches Ralph Stewart - A Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting with Acute Coronary Syndrome Treated with Losmapimod Compared to Placebo Tom Wang- Myocardial infarction associated with Coronary Artery Bypass Grafting (Type 5 MI) as detected by highsensitivity troponin T (hsTn-T) Tom Wang - High sensitivity troponins and outcomes in patients admitted to coronary care unit Cara Wasywich- Does diastolic pulmonary gradient alter haemodynamic assessment of suitability for cardiac transplantation? Cara Wasywich - A feasibility study of cardiac haemodynamic assessment by cardiac catheterisation augmented with cardiac MR imaging Timothy Watson- Diagnostic yield of elective coronary angiography Mark Webster - ACIST Diagnosis of Coronary Arterial Disease with a Rapid Exchange Monorail Pressure Sensor (MPS) for the Measurement of Fractional Flow Reserve (FFR) Protocol No: NZ100" Mark Webster - Treatment of rEsistant hypertension using a radiofrequency percUtaneous transluminal angioplasty CathetEr Mark Webster- Intra-coronary Cooling (Evaluation of Outcomes) Before Angioplasty Revascularisation in ST Elevation Myocardial Infarction (ICEOBAR-STEMI) Mark Webster- International, Non-randomized, First-InHuman Study of the EnligHTN Generation 2 System in Patients with Drug-Resistant Uncontrolled Hypertension Mark Webster- Safety & Performance Study of the ReZolve2 Sirolimus-Eluting Bioresorbable Coronary Scaffold – RESTORE II Trial Mark Webster- EVOLVE II QCA Trial- A clinical study to assess angiographic and intravascular ultrasound outcomes of the SYNERGY™ Stent System for the treatment of narrowed coronary artery Mark Webster - Neuromodulation for uncontrolled Hypertension Mark Webster - Understanding the effects of localized intracoronary hypothermia on ischaemia and microvascular function Mark Webster - A First In Human (FIH) study to assess safety and performance of hepatic sympathetic denervation for treatment of inadequately controlled type 2 diabetic subjects on oral anti-hyperglycemic agents Cynthia Wensley - Patient comfort after cardiac surgery- an evidence-based, patient-centred approach Jonathon White - Understanding troponin elevations in acute exacerbation of chronic obstructive pulmonary disease: a cardiac magnetic resonance imaging study Alistair Young- Peak Heart Rate during Upright Treadmill and Supine Cycling Alistair Young - Assessment of 3D heart shape in congenital heart disease Cardiology (Starship): Luke Eckersley - Epidemiology of important congenital heart disease in New Zealand Tom Gentles - Fontan liver and renal study Tim Hornung - Long term outcomes after arterial switch operations for transposition of the great arteries Luciana Marcondes- Progression of right ventricular dilation after repair of tetralogy of Fallot- medium term follow up Musthafa Janeel Moosa - Scimitar Syndrome: single centre experience Beau Pontre - Innovative MRI assessment of myocardial geometry and fibre architecture in ex vivo congenital heart disease (CHD) specimens Kathryn Rice - Echocardiographic Review of Dynamic Diastolic Function and Preload Markers in Fontan Patients Jon Skinner - New Zealand experience of an Epicardial approach to Implantable Cardiac Defibrillators in children Jon Skinner - Targeted Next Generation Sequencing to identify the genetic causes of heritable cardiac disorders 23 Cardiology (Starship): continued Jon Skinner - The physical and psychological consequences of left cardiac sympathetic denervation in the management of long QT syndrome and catecholaminergic ventricular tachycardia Jon Skinner - Wolff-Parkinson-White Syndrome and Sudden Death Nigel Wilson - The significance of rheumatic heart disease detected by echocardiography Cardiothoracic Surgical Unit: Indran Ramanathan - The safety and efficacy of dorsal root replacement in the treatment of patients with aortic root pathology Indran Ramanathan - Understanding the carbon footprint of cardiothoracic surgery Tim Willcox - Perfusion Down Under Collaboration Database Tim Willcox- Reducing red blood cell transfusion in cardiac surgery: a multicentre quality improvement initiative of the Perfusion Downunder Collaboration (using PDUC Database) Tim Willcox - The Goal dIrected perFusion Trial: A multicenter, prospective, randomized, controlled study Cardiovascular Intensive Care Unit: Fleur Bethell - A pilot study to evaluate the effect of a brief psycho-education intervention in Cardiac Intensive Care Unit survivors with Post Traumatic Stress Disorder symptomatology David Buckley - Clinical Usability Assessment of the 95X Humidifier Eileen Gilder - Audit of practice: Theraputic Hypothermia Michael Gillham- A randomised, double-blind, multi-centre placebo controlled trial of dexmedetomidine for patients with agitation and delirium in the intensive care unit (DahLA) 24 Michael Gillham- MicroRNA biomarkers for the early diagnosis of Non Occlusive Mesenteric Ischaemia Chang Joon Kim- Prevalence of preoperative anaemia in patients having cardiac surgery and its impact on clinical outcome Shay McGuinness - Analgesic, Sedative and Antibiotic Pharmacokinetics during Extra Corporeal Membrane Oxygenation : Understanding altered pharmacokinetics to improve outcomes Shay McGuinness - Fluid therapy after cardiac surgery- a feasibility study Shay McGuinness - A Multicenter, Open-Label, Randomized Study to Compare the Safety and Efficacy of Intravenous Ceftolozane/Tazobactam with that of Piperacillin/ Tazobactam in Ventilator Associated Pneumonia Shay McGuinness- Trial of early activity and mobility in ICU Shay McGuinness- Prophylactic Intra-aortic Balloon Counterpulsation in High-Risk Cardiac Surgery: An inception cohort study (PINBALL) Shay McGuinness- Therapeutic hypercapnia after cardiac arrest: a pilot feasibility and safety randomized controlled trial Shay McGuinness- Supplemental Parenteral Nutrition in Critically Ill Patients: A Pilot Randomised Controlled Study Shay McGuinness- Pilot randomised controlled trial of early mobilisation in critically ill patients to improve functional recovery and quality of life Shay McGuinness- A multi-centred randomised cross over trial investigating the safety and efficacy of using 0.9% saline or Plasma Lyte® 148 as the primary resuscitation fluid in adult intensive care patients Shay McGuinness - A Prospective, Randomized, DoubleBlind, Multicenter, Phase 3 Study to Assess the Safety and Efficacy of Intravenous Ceftolozane/Tazobactam compared with Meropenem in Adult Patients with Ventilated Nosocomial Pneumonia Shay McGuinness - The Fluid Translation of Research into Practice Study: An International Cross-Sectional Survey of Fluid Resuscitation Practice Colin McArthur- Practice pattern variation in discontinuing mechanical ventilation in critically ill adults: an international prospective observational study (IOSWeaning) Shay McGuinness - A Phase 3 Randomized Double-blind Study Comparing TR 701 FA and Linezolid in Ventilated Gram-positive Nosocomial Pneumonia Colin McArthur - Early goal-directed sedation in mechanically ventilated intensive care patients SPICE Kate Ormrod- Nutrition Therapy in adults requiring ECMO in Australia and New Zealand Rachael Parke- Fluid therapy after cardiac surgery Rachael Parke- A study to describe the airway pressures generated by a wide range of flows provided by high flow humidified nasal oxygen therapy and the effect on regional lung ventilation. (SHOT study) Rachael Parke- Fluid challenges in intensive care: how do we administer fluids in the ICU? (FENICE trial) Janarthanan Sathananthan- The appropriateness of discharge medications at time of discharge from cardiac surgery: A 1 year audit Colin McArthur - Stress ulcer prophylaxis in the intensive care unit. A multicentre inception cohort study (SUP-ICU) Colin McArthur - A week in the neurocritical care unit: point prevalence observational study in neurocritical care: PRINCE study Colin McArthur - Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (PATCH) Study Lynette Newby - Large observational study to Understand the Global Impact of Severe Acute respiratory FailurE Janine Rouse- Discharge delay for Critical Care patientsStaff perspectives of the impacts on patients and staff Dermatology: Critical Care Medicine: Steven Lamb – Australasian Psoriasis registry Doug Elliott - Ventilator Associated Pneumonia: developing consensus for a pragmatic 'clinical surveillance' definition and measuring current incidence in Australian and New Zealand ICUs Harriet Cheng - Dermatology In-patient Service Review Colin McArthur- The CLARITY study: an audit of temperature regulation in intensive care patients with traumatic brain injury and stroke in Australia and New Zealand Colin McArthur- A randomised blinded placebo controlled trial of hydrocortisone in critically ill patients with septic shock Colin McArthur - Standard issue transfusion versus fresher red blood cell use in intensive care Colin McArthur - Southern Hemisphere Influenza vaccine effectiveness, research and surveillance (SHIVERS): Objective 1- Hospital-based surveillance for severe acute respiratory infections caused by influenza and other respiratory pathogens Harriet Cheng - Effect of topical corticosteroid therapy under occlusion on endogenous cortisol production Diabetes Service: Melanie Beatty - Where do adolescents with diabetes currently get their information from about risk reduction education? Tim Cundy/Jasmine Tan - Remission rates with aggressive antihypertensive regimen: Case series of 36 patients from Langimalie Clinic Rosie Dobson - Cross sectional survey of the use of mobile health interventions in young people with type 1 diabetes Anna Friis - Does Kindess Matter? A Randomised Controlled Trial investigating the role of self-compassion in reducing depression and improving compliance in diabetes patients 25 Diabetes Service: continued Manish Khanolkhar - Audit on inpatient hypoglycaemia management in adult Diabetes Mellitus subjects admitted to Auckland City Hospital Manish Khanolkhar - Retrospective clinical audit to estimate the level of metabolic control and the prevalence of diabetes complications in patients with diabetes mellitus attending the Auckland DHB Young Adult Diabetes Clinic Annika Lam- Audit on medium term diabetes outcomes and insulin prescribing patterns at the Auckland Diabetes Centre Jasmine Tan – Five year longitudinal study of native renal biopsies in patients with type 2 diabetes in the Auckland Region Jasmine Tan- Survival and cardiovascular outcomes in patients with type 2 diabetes and end stage renal disease on dialysis – A retrospective observational study Bernard Venn- Postprandial glycaemia in Asian type 2 diabetics Ben Wheeler - Evaluating the insulin pump discontinuation action plan- impact on patient and family confidence, anxiety and knowledge Fiona Wu- Auckland and Waitemata District Health Boards Diabetes Retinal Screening Outcomes Cohort Study Fiona Wu - Audit of patients with Type 2 Diabetes and hospital admissions with cellulitis between 1 Jan 2011- 31 Aug 2013 Emergency (Adult): Peter Jones - The Asia, Australasia and New Zealand Dyspnoea survey in the EMergency departments (AANZDEM study) Sinan Kamona - New Zealand Emergency Medicine Network ED Airway Registry of NZ Emergency Department Airway Practices Acrane Li - Impact of pre-operative imaging on the surgical outcome of Emergency Department patients with suspected appendicitis 26 Timothy Tenbensel - Evaluating the Auckland After Hours Initiative Emergency (Starship): Chris Bullen - Opportunistic Provision of Smoking Cessation Support at Children’s Emergency Department, Starship, Auckland City Hospital Joanne Cole - A Fitness for Purpose Study of the Field Assessment Conditioning Tool (FACT) Stuart Dalziel - Paediatric Emergency Research- HRC Fellowship Stuart Dalziel - The A-PHIRST study (Australasian Paediatric Head Injury Rules Study): a prospective observational study comparing existing paediatric minor head injury clinical decision rules Stuart Dalziel - Utilisation of cranial computed tomography scanning for paediatric head injury in Australasia Stuart Dalziel - Convulsive Status Epilepticus Paediatric Trial (ConSEPT) Study Stuart Dalziel - Global Pediatric Emergency Poisoning Surveillance System Stuart Dalziel - Pharmacotherapy Practice Patterns and Outcomes in Bronchiolitis in the America’s, Australia/NewZealand and Europe Stuart Dalziel - Ibuprofen and Paracetamol in Asthma Causation (iPAC) feasibility study Stuart Dalziel - Bell’s Palsy in Children: A Retrospective Chart Review Bernard McCarthy - A prospective analysis of children, with infection and requiring fluid bolus, in the Starship Children's Emergency Department Michael Shepherd - Refreshing Cardio-Pulmonary Resuscitation using In-Situ Training (ReCPR-IST) Endocrinology (Adult): Tim Cundy - Randomised Trial of Genetic Testing and Targeted Zoledronic acid Therapy to Prevent SQSTM1 Mediated Paget’s Disease (Zoledronate in the Prevention of Paget’s) Maritza Farrant - The management and outcomes of prolactinomas in pregnancy Keith Petrie- Do Bone Models Help Patients Better Understand Osteoporosis (The Model Study) Endocrinology (Starship): Wayne Cutfield - The incidence of new-onset DKA in children with T1DM in Auckland 2000 – 2009 Paul Hofman- Can lifestyle changes during pregnancy improve pregnancy outcomes and protect offspring from the effects of an obesogenic environment Paul Hofman - Efficacy and safety of liraglutide in combination with metformin versus metformin monotherapy on glycaemic control in children and adolescents with type 2 diabetes Craig Jefferies - Clinical trial of Zoledronic acid (Aclasta) in children and adolescents with Duchenne muscular dystrophy Gastroenterology (Adult): Dagmar Hendel - Utility of upper gastroscopy in the setting of frank PR bleeding Mark Lane - A MC, Rand. DB, Placebo-Controlled, ParallelGroup Study of Oral CP-690,550 As An Induction Therapy in Subjects With Moderate To Severe Ulcerative Colitis Mark Lane - A MC, Rand. DB, Placebo-Controlled, ParallelGroup Study of Oral CP-690,550 As A Maintenance Therapy In Subjects With Ulcerative Colitis Mark Lane - A MC, OL Study of CP-690,550 In Subjects With Moderate To Severe Ulcerative Colitis Mark Lane - A study to determine patient specific and general beliefs towards medication and their treatment compliance to selected systemic therapies in chronic inflammatory diseases (ALIGN) David Orr - Very low calorie diet (VLCD) followed by fibre and probiotic supplementation is superior to VLCD alone in achieving sustained weight loss and resolution of NonAlcoholic Fatty Liver Disease. David Orr- Very low calorie diet (VLCD) followed by fibre and probiotic supplementation is superior to VLCD alone in achieving sustained improvement in weight loss and the metabolic syndrome post Liver Transplant. David Rowbotham - The prevalence and management of Eosinophilic Oesophagitis in NZ David Rowbotham - Does acute appendicitis over the age of 40 years correlate with increased risk of developing colorectal cancer: a ten year retrospective review at ADHB Yuriko Wilkins- Is increased oral hydration during bowel preparation associated with improved clarity and quality of bowel cleansing? Gastroenterology (Starship): Ross Anthony - Faecal Calprotectin as a non-invasive biochemical marker of inflammatory bowel disease in the paediatric population Jonathan Bishop - Prospective Study to assess validity of the use of serological markers to diagnose Coeliac Disease in New Zealand children according to ESPGHAN diagnostic guidelines Helen Evans - Do New Zealand babies with biliary atresia present to specialist services later than in overseas centres due to lack of awareness of the disease? Helen Evans - Complication rate of paediatric liver biopsies at Starship Hospital? Helen Evans - Study of micronutrient levels and requirements in paediatric intravenous nutrition (rVN) 27 Gastroenterology (Starship): continued Helen Evans - Defining the genetic disposition to Biliary Atresia Stephen Mouat- Portal hypertensive bleeding in paediatric patients at Starship Children’s Hospital Amin Sheikh - Growth & Bone Mineral Density 5 years post Paediatric Liver Transplant General Medicine: Geoff Braatvedt - Diabetic ketoacidosis in Auckland Hospital in three five-year periods Robyn North - Statin use in the elderly Haematology (Adult): Leanne Berkahn - A Phase 3, Randomised, DoubleBlind, Multicenter study comparing oral MLN9708 plus Lenalidomide and Dexamethasone versus placebo plus Lenalidomide and Dexamethasone in adult patients with relapsed and/or refractory multiple myeloma Leanne Berkahn - A phase III, randomised, observer-blind, placebo-controlled, multicentre, clinical trial to assess the prophylactic efficacy, safety, and immunogenicity of GSK Biologicals’ herpes zoster gE/AS01B Leanne Berkahn - A Phase 3 Study of IPI-145 versus Ofatumumab in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Leanne Berkahn - A Study of IPI-145 and Ofatumumab in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia previously enrolled in Study IPI 14507 Peter Browett- A Phase 3, Randomized, Two-Arm, Open-Label, Multicenter, International Trial of Alisertib (MLN8237) or Investigator’s Choice (Selected Single Agent) in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma 28 Peter Browett - A Randomized, Double-Blind, Multicenter Study of Denosumab Compared with Zoledronic Acid (Zometa) in the Treatment of Bone Disease in Subjects with Newly Diagnosed Multiple Myeloma Richard Doocey- A Randomized, Open-label, Phase 3 Study of Carfilzomib Plus Dexamethasone vs. Bortezomib Plus Dexamethasone in Patients with Relapsed Multiple Myeloma (The ENDEAVOUR trial) Timothy Hawkins - A Randomized, Multicenter, Open-label, Phase 3 Study of the Bruton’s Tyrosine Kinase Inhibitor PCI-32765 versus Chlorambucil in Patients 65 Years or Older with Treatmentnaive Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Timothy Hawkins - An Open-label Extension Study in Patients 65 Years or Older with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Participated in Study PCYC-1115-CA (PCI-32765 versus Chlorambucil) Paul Ockelford - Reduced-dosed rivaroxaban and standarddosed rivaroxaban versus ASA in the long-term prevention of recurrent symptomatic venous thromboembolism in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism Nigel Patton - A Phase 3 Study to Evaluate the Efficacy and Safety of Dinaciclib or Ofatumumab in Subjects with Refractory Chronic Lymphocytic Leukaemia. Nigel Patton- An Open-label, Single arm, Multicenter Phase 2 Study of the Bruton’s Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma with 17p Deletion Nigel Patton - A Phase III Randomized, Placebo-controlled Clinical Trial to Evaluate the Safety and Efficacy of MK-8228 (Letermovir) for the Prevention of Clinically Significant Human Cytomegalovirus (CMV) Infection in Adult, CMVSeropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients Lucy Pemberton - A Programme of Development for Older Patients with Acute Myloid Leukaemia or High Risk Myelodyplastic Sydrome (AML LI) Lucy Pemberton- A Phase 3 Randomized, Open-Label Study of Ponatinib versus Imatinib in Adult Patients with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase Lucy Pemberton - Audit of outcomes in patients with monosomal karyotype AML Joanne Scott - Amyloid Mass Spectometry – a case series based on local experience in New Zealand Laura Young - Anticoagulant reversal and effects study (ARES) Collaborative Laura Young - A Phase III case series clinical study of the reversal of the anticoagulant effects of dabigatran by intravenous administration of 5g idarucizumab (BI 655075) in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures Laura Young - Cancer screening and the incidence of cancer diagnoses in spontaneous venous thromboembolism patients at Auckland City Hospital Haematology/ Oncology (Starship): Stephen Laughton - COG ACNS0821: Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/ Refractory Medulloblastoma/CNS PNET (Primitive Neuro-Ectodermal Tumour) of Childhood, A COG Rand.PII Screening Trial Stephen Laughton - Children’s Oncology Group (COG) ACNS0831: Phase III Randomised Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years Stephen Laughton - COG ACNS1022: A Phase II Randomised Trial of Lenalidomide in Paediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas Stephen Laughton- Australian Children’s Clinical Trials Study Number ACCT007. Phase I study of vinorelbine, cyclophosphamide and Rapamycin for recurrent malignancies in children Stephen Laughton - CPT-SIOP-2009: Intercontinental Multidisciplinary Registry and Treatment Optimisation Study for Patients with Choroid Plexus Tumours Stephen Laughton - Neuropsychological, Social, Emotional, and Behavioural Outcomes in Children with Cancer. ALTE07C1 Peter Bradbeer - International Collaborative Treatment Protocol For Infants Under One Year With Acute Lymphoblastic Or Biphenotypic Leukemia (Interfant06) Stephen Laughton - ACNS0822 A Randomized Phase II/ III Study of Vorinostat (IND#71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab (IND#7921) and Local Irradiation Nyree Cole - Therapeutic infusion of most closely HLAmatched third party donor-derived virus-specific cytotoxic T-lymphocytes in patients with active viral reactivation postallogeneic stem cell transplantation (R3ACT) Rachel Longwell - An evaluation of the New Zealand National Bone Marrow Registry- the differential probabilities of different ethnicities in finding a suitably matched, unrelated haemopoietic stem cell donor Mandy de Silva - Ototoxicity as a Predictor of Outcome in Osteosarcoma Patients treated with Cisplatin Scott Macfarlane- COG:AALL06N1 – A study of Neurocognitive Function in Children Treated for ALL. A Group-wide, Non-Therapeutic Companion Study to AALL0232 and AALL0434 Chow Yee Lai - High dose chemotherapy, with autologous stem cell support/transplant related morbidity and mortality for patients with Medulloblastoma/Supratentorial PNET (Primitive Neuroectodermal Tumour) treated on the SJMP-96 Scott Macfarlane- International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis 29 Haematology/ Oncology (Starship): continued Scott Macfarlane - Cost benefit analysis of the use of routine serological titres in reducing the burden of re-immunisation in chiildren who have undergone chemotherapy for childhood cancer Mark Winstanley- Pilot Study Using Myeloablative Busulfan/Melphalan (BuMel) Consolidation Following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma Jane Skeen- Children’s Oncology Group (COG) AREN0534: Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumour Mark Winstanley - Children’s Oncology Group AEWS1031 A Phase III Randomized Trial of Adding Vincristine-TopotecanCyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma Jane Skeen – Our child has died – hear our story Michael Sullivan- Adolescent and Young Adult Cancer Services – A Patient Experience Evaluation of Those Aged 12-24 Years Enrolled With AYA Key Workers Between 1st January and 31st December 2011 Lochie Teague - AALL1131: A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukaemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Lochie Teague - COG ASCT1221: A Randomized Phase II Study Comparing Two Different Conditioning Regimens Prior to Allogenic Hematopoietic Cell Transplantation (HCT) for Children with Juvenile Myelomonocytic Leukemia (JMML) Lochie Teague - Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localised Central Nervous System Germ Cell Tumours (CNS GCT) Mark Winstanley- COG ARST0921: A Randomized Phase II Trial of Bevacizumab (IND# 7921, Avastin) and Temsirolimus (IND# 61010, Torisel) in Combination with Intravenous Vinorelbine and Cyclophosphamide in Patients with Recurrent/Refractory Rhabdomyosarcoma Mark Winstanley - COG ANBL1221: A Phase II Randomised Trial of Irinotecan/ Temozolamide with Temsirolimus (NSC# 683864, IND# 61010) or Chimeric Antibody Ch 14.18 (NSC# 623408, IND# 4308) in Children with Refractory, Relapsed or Progressive Neuroblastoma Mark Winstanley - New Zealand Adolescent and Young Adult Cancer Incidence and Survival 2000-2009 30 Mark Winstanley - AEPI10N5: Genetic Epidemiology of Ewing Sarcoma (Project GenESis) He Kamaka Waiora: Bridget Robson - Unequal treatment- the role of Health Services (part II. Ischaemic Heart Disease & Maternity). Helen Wihongi - Trialling a National Māori review form at the Auckland, Waitematā, and Wellington DHBs Immunology-Clinical: Rohan Ameratunga - Evaluation of Tim-3 as a cellular marker in Immunodeficient patients Immunology-Starship: Annaliesse Blincoe - Do Defects in the Innate Immune System Contribute to Non-Cystic Fibrosis Bronchiectasis in Maori and Pacific Island Children? Infectious Diseases (Adult): Simon Briggs: Improving unnecessary intravascular-line removal on General Medical Wards at Auckland City Hospital Simon Briggs - Potential earlier diagnosis of HIV infection if the routine offer of HIV testing was introduced at ADHB Rebekah Lane - The Auckland Typhoid Experience: A retrospective review of cases of enteric fever from 20052010 at the three district health boards in Auckland City Rebekah Lane - Baseline audit of cefuroxime and metronidazole use in four departments at Auckland City Hospital- General Surgery, Urology, Gastroenterology and General Medicine Ivone Leong - Targeted and whole exome sequencing to identify the genetic causes of long QT syndrome Christopher Luey - The impact of loading doses and a vancomycin calculator on target vancomycin trough concentration achievement at two Auckland hospitals: a prospective study Arthur Morris- Candida albicans hypermutable genes. Basic biology and potential use in risk stratification for candidemia patients Susan Mundt - Experiences of HIV stigma and discrimination in the healthcare settings Mitzi Nisbet - Audit of screening and treatment for Latent Tuberculosis Infection in patients with HIV infection, Auckland City Hospital Mitzi Nisbet - How many induced sputum samples are required to diagnose smear negative TB Keith Petrie- The SMART Study: Can a Smartphone application improve adherence to antiretroviral therapy? Stephen Ritchie - Understanding nasal flora and prevention of Staphylococcus aureus disease Stephen Ritchie - Use of hospital inpatient services by people living with HIV/AIDS Infectious Diseases (Starship): Michael Baker - New Zealand Rheumatic Fever Risk Factors Study Rachel Webb - Familial study of Rheumatic Fever using Echocardiography and Gene Expression Profiling LabPlus (Genetics, Immunology, Microbiology, Virology): Mary De Almeida - Investigation of a cluster of hospitalacquired invasive pneumococcal disease cases at Auckland City Hospital Donald Love - Cardiac inherited disease registries Arthur Morris- Susceptability of bloodstream Candida species to Echinocandins Sally Roberts - Is Clostridium difficile PCR-ribotype NZ11/21 more likely to be associated with severe community-onset disease than other PCR-ribotypes in the Auckland setting? Sally Roberts - Genetic analysis of emerging ceftriaxone resistance among isolates of gonorrhoea Sally Roberts - Global Antimicrobial Susceptability Surveillance Program Sally Roberts - Study for Monitoring Anti-Microbial Resistance Trends Sally Roberts - Assessing the role of echocardiography in patients with Staphylococcus aureus bacteraemia Clinton Turner - Review of MGMT promoter methylation analysis at ADHB Deborah Williamson- A prospective observational casecontrol study of the clinical and molecular epidemiology of skin and soft tissue infections in paediatric patients presenting to Starship Children’s Hospital Auckland, New Zealand. Deborah Williamson - Population-based assessment of the epidemiology and outcomes of Staphylococcus aureus infections at the Auckland District Health Board, 2001-2011 Deborah Williamson - Validity of hospital discharge coding in diagnosing microbiologically confirmed Staphulococcus aureus infections Fintan Garavan - Clozapine-Associated Myocarditis and Cardiomyopathy: Investigating a Metabolic Basis of Toxicity 31 Liver Transplant Unit: William Abbott - Search for therapeutic targets that initiate HBeAg seroconversion and decrease the risk for liver cancer in chronic hepatitis B William Abbott- Prediction of chronic hepatitis B by sequencing the S open reading frame Ed Gane - A Phase 3, Safety and Efficacy Study of Boceprevir/Peginterferon Alfa-2a/ribavirin in Chronic HCV Genotype 1 IL28B CC Subjects Ed Gane - An Open-Label Study to Explore the Clinical Efficacy of GS 7977 with Ribavirin Administered PreTransplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant Ed Gane - GS-US-283-0106 A Double-Blind, Randomized, Placebo-Controlled, Single and Multiple-Dose Ranging, Adaptive Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antiviral Activity of GS-9620 in Treatment Ed Gane - GS-US-283-0102: A Double-Blind, Randomized, Placebo-Controlled, Single and Multiple-Dose Ranging, Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antiviral Activity of GS-9620 in Virologically Ed Gane- A Phase 3, Randomized, Double-Blind, Controlled Study Evaluating the Efficacy and Safety of Peginterferon Lambda-1a, with and without Daclatasvir, Compared to Peginterferon Alfa-2a, Each in Combination with Ribavirin in Partial Responders to Peginterferon Alfa and Ribavirin (P/R), Intolerant or Ineligible to P/R Subjects and Treatment- Naïve Subjects with Chronic Hepatitis C Genotype 1b Infection Ed Gane - An Open-Label Re-treatment Study with PegInterferon Alfa-2a, Ribavirin and BMS-790052 With or Without BMS-650032 for Subjects With Chronic Hepatitis C Ed Gane - GS-US-334-0109: An Open-Label Study of GS7977 + Ribavirin for 12 Weeks in Subjects with Chronic HCV Infection (GT 2 or GT3) who Participated in Prior Studies Evaluating GS-7977 32 Ed Gane - A Phase 2, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of GS-7977 and Ribavirin for 24 weeks in Subjects with Recurrent Chronic HCV Post Liver Transplant Ed Gane - A Phase 2, Multicenter, Open-Label Randomized Study to Investigate the Safety and Efficacy of GS-7977 and Ribavirin Administered for 24 weeks in Patients Infected with Chronic HCV with Cirrhosis and Portal Hypertension with or without Ed Gane- A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of ABT-450/ Ritonavir/ ABT 267 (ABT-450/ritonavir/ABT-267) and ABT333 Co administered with Ribavirin (RBV) i Ed Gane - A Phase 1 Open LabelParallel Group Single Dose Study to Evaluate the Pharmacokinetics of GS5885 in Subjects with Normal Hepatic Function and Severe Hepatic Impairment Ed Gane- BV28333- An exploratory evaluation of interleukin 28B (IL28B) genotype, protein and RNA biomarkers in serum samples (stored, already obtained from completed studies) from subjects with HBe-antig Ed Gane - A Phase 4, blood sample collection study for exploratory evaluation of the association of single nucleotide polymorphisms with treatment responses from subjects Ed Gane - A Phase III, Randomised, Double-Blind Study of Tivantinib (ARQ197) in Subjects with Met Diagnostic-High Inoperable Hepatocellular Carcinoma (HCC) Treated with One Prior Systemic Therapy Ed Gane - A Phase II trial of Refametinib as first or second line treatment in patients with RAS mutant unresectable advanced or metastatic Hepatocellular Carcinoma (HCC) Ed Gane - A Follow-up Study to Assess Resistance and Durability of Response to AbbVie Direct-Acting Antiviral Agent (DAA) Therapy in Subjects Who Participated in Phase 2 or 3 Clinical Studies for the Treatment of Chronic Hepatitis C Virus (HCV) Infection Ed Gane - Molecular predictors of response to sorafenib as adjuvant therapy after resection in hepatocellular carcinoma. Tissue biomarker study of the STORM randomized trial (BIO-STORM) Management: Ed Gane - A Phase 3, Multicenter, Open-Label Study to Investigate the Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination for 12 Weeks in Subjects with Chronic Genotype 1 or 4 Hepatitis C Virus (HCV) Dora Bocirnea - Investigating Patient Satisfaction with Complaint Resolution Ed Gane - An Open-Label, Multicenter Study To Evaluate The Efficacy And Safety Of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin For 12 or 24 Weeks In Chronic Genotype 1 HCV Infected Participants Who Participated Ed Gane - A prospective, single-arm, multicenter, uncontrolled, open-label Phase II trial of refametinib (BAY 86-9766) in combination with sorafenib as first line treatment in patients with RAS mutant Hepatocellular Carcinoma (HCC) Ed Gane - Directly acting antiviral (DAA) based therapy for recently acquired hepatitis C II Ed Gane - A Phase IIBIII, openlabel, randomized, comparative study to assess the efficacy of ABX203 to maintain control of Hepatitis B disease after cessation of treatment with nucleos(t)ide analogs in adult HBeAg negative patients with chronic Hepatitis B in the Asia Pacific region Rachael Harry- Improving the long term outcome of paediatric liver transplant recipients in New Zealand: Identifying risks and protective factors for outcomes in adolescence and early adulthood Peter Beaver - The effects of organisation and governanance on patient safety in NZ public hospitals Deidre Maxwell - Understanding governance arrangements concerning public health sector clinical networks in New Zealand Paul Rouse- Developing a multi-stakeholder performance measurement framework for health services contracting Mental Health (Adult): Nadav Avny - Mindfulness based stress reduction (MBSR) for ADHB staff Jane Casey - Clinical utility of some commonly used cognitive screening tools in New Zealand Liesje Donkin - Parental experience of Maudsley Family Based Treatment (MFBT) Emme Chacko - Metabolic Side Effects of Atypical Antipsychotics in Older Adults Gary Cheung - Assessing Capacity to Engage in Advance Care Planning in Older People Gary Cheung - Late Life Suicide Attempt Study Gary Cheung - Routine assessment of depressive symptoms in older people- the New Zealand experience with interRAI Brett Knock- Investigation of Psychological, Physiological and Psychosocial Problems in Hepatitis C Patients Following Pegylated Interferon Alpha Pls Ribavirin Treatment Gary Cheung - Validity of the InterRAI outcome scales for older adults in specialist mental health services Alex Lampen-Smith- Future care preferences in patients with advanced liver cirrhosis Mark Franks - The clinical utility of a cognitive behavioural psychological forumlation in the treatment of depression and anxiety: a Pasifika case example Chris Moyes - Audit of AFP screening for detection of Hepatocellular Carcinoma in carriers of Hepatitis B Virus Alison McKinlay - How do older adults cope with a diagnosis of mild cognitive impairment? 33 Mental Health Adult: continued Sione Maka - A qualitative survey on the impacts of Lotofale Pacific Island Mental Health Services' group on clients: a Pacific Island social work perspective Anthony O’Brien - Use of restrictive measures in inpatient mental health services Hiran Thabrew - Game for Health: Development of a modular eHealth resource for children and adolescents with chronic illness Chandni Prakash - Review of mood stabiliser and antipsychotic use in Maternal Mental Health Service users in pregnancy and postpartum and outcome Tania Windelborn - Examination of the utility of a self help computerised cognitive behavioural programme (SPARX) in an acute adolescent in-patient unit Kate Prebble - A history of the establishment of forensic psychiatric services in the Auckland region: An exploration of archival evidence National Women’s Health – Jemaima Tiatia - Suicidal Behaviours and Ideation Amongst Samoan People: The Journey Towards Prevention Fertility Plus, Gynaecological Oncology, High Risk Maternity, Midwifery, Obstetrics and Gynaecology: Malcolm Tingle - Clozapine-associated myocarditis and cardiomyopathy: investigating a metabolic basis of toxicity Tony Baird - The drinking habits of women during pregnancy Jane Walton - An Efficacy and Safety Trial of MK-8931 in subjects with amnestic Mild Cognitive Impairment due to Alzheimer’s Disease (Prodromal AD) Philip Baker - Environmental factors that are likely to influence pregnancy – in particular fetal growth restriction Sara Weeks - F1D-MC-B034(a) Post-Injection Syndrome in Patients with Schizophrenia Receiving Olanzapine LongActing Injection Richard Worrall - Understanding patients’ experiences of Fraser McDonald Unit and the impact of these on its design Mental Health (Starship): Caleb Armstrong - Review of demographics and other characteristics of youths undergoing court ordered assessment by the Regional Youth Forensic Service over a 12 month period Maneesh Deva – Clinical audit of inpatient eating disorders service Starship Children’s Hospital 2005- 2012 Peter Dowrick- Video self modelling in food selectivity Kerry Gibson - Young People’s narrative accounts of their experiences of psychological assessment and counselling 34 Josephine Stanton - Referrers’ perspectives of engaging with the Child and Family Unit Johanna Bannister- Do interventions have a positive impact on women who disclose partner violence in a health-care setting? Larry Chamley- Understanding the placenta: the life cycle of placental trophoblasts in health and diseases of pregnancy Catherine Cook- Cervical smears and other gynaecological examinations: The perceptions of women and health professionals Catherine Cook - Perceptions of women about factors that account for delays from initial symptoms of endometrial cancer to specialist referral Lisa Dawes - A Blinded Prospective Observational Study Comparing Qualitative fFN, Quantitative fFN and PartoSure (PAMG-‐1) to assess the Risk of Preterm Birth in Women with Threatened Preterm Labour Natalie Desmond - Maternal general practice enrolment data-match audit to improve the newborn continuum of care Isabelle Eadie - Midwifery practice in an Obstetric High dependency Unit in New Zealand Lois Eva - PRINCess- The Conservative Management of Cervical Intraepithelial Neoplasia (CIN2) in Young Women to Age 25 Cindy Farquhar - Fertility Urinary Monitoring Study: Assessment of urine metabolites to identify hormonal responses. Cindy Farquhar – The intraUterine Insemination (TUI) study Sarah Fitzgibbon- Management of abnormal uterine bleeding at Auckland District Health Board Premjit Gill - An Evaluation of Body Mass Index and Ethnicity and Endometrial Hyperplasia/Cancer in Premenopausal Women with Abnormal Uterine Bleeding Elizabeth Glanville- Management of women following excision of vulval intraepithelia neoplasia Katie Groom- MAgnesium Sulphate At 30 To 34 Weeks’ GEstational Age: Neuroprotection TriAl Katie Groom- STRIDER: A Randomized Controlled Trial of Sildenafil Therapy in Dismal Prognosis Early-Onset Intrauterine Growth Restriction (New Zealand and Australia Katie Groom- The Fetal OXygenation Study. Free fetal RNA in the maternal circulation: a biomarker of intrauterine hypoxia in growth-restricted fetuses. (FOX Study) Katie Groom - The WISH Project Follow Up Study Devashana Gupta - Endometrial injury in women with subfertility undergoing IVF/ICSI or expectant management; the Pipelle Injury in Pregnancy (PIP) studies Fiona Keogh- HE 4 as a tumour marker for the prediction of ovarian carcinoma Logeswary Kumarasamy - Patient satisfaction with Jadelle Contraceptive Implant: The National Women's Hospital Experience Bev Lawton - Assessing potentially preventable severe acute maternal morbidity: Extension from 4 DHBs to a National SAMM review Emma McGoldrick - Identifying the barriers and enablers in the implementation of the New Zealand and Australian Antenatal Corticosteroid Clinical Practice Guideline. A randomised controlled trial protocol Claire McLintock- A national population-based study of rheumatic heart disease in pregnancy Ed Mitchell- Ed Mitchell- Maternal Sleep in Pregnancy Ellie Moon- Evaluation of the safety of New Zealand’s maternity system: the relationship between maternity care provider and fetal and neonatal outcomes Helen Roberts- Follow up of midwife Jadelle insertions Helen Roberts - Bleeding patterns and nonmenstrual adverse event rate following immediate insertion post abortion of the contraceptive implant Jadelle and the effect on continuation rates at one year Janet Rowan- Metformin in Gestational Diabetes: The Offspring Follow Up at 7-9 years Suzanne Stevens - Prenatal Alcohol Exposure, Genetic Interplay and Neurobehavioural Development (Pilot Study) Peter Stone - A novel method for non-invasive antenatal diagnosis by harvesting trophoblasts Peter Stone - An investigation of the effect of antihypertensives on endothelial activation in preeclampsia Victoria Taylor - Pregnancy associated Plasma Protein (Papp-A) and Association with Small for Gestational Age (SGA) and Intrauterine Fetal Demise (IUFD)-Does the overseas story apply in NZ? Michelle Wise- The BEC Study: An evaluation of body mass index and ethnicity and endometrial hyperplasia/cancer in premenopausal women with abnormal uterine bleeding. 35 National Women’s Health: continued Michelle Wise- Satisfaction with birth experience and with antenatal consultation about previous caesarian Jennifer Pereira - A national incidence study of Multiple Sclerosis (MS) in New Zealand Michelle Wise - Womens’ preference for subsequent births after a primary Casearean Section: An early post-natal review of attitudes Richard Roxburgh - Factors influencing patient experience in diagnosis of genetic disease – a retrospective study investigating the experience Huntingtons disease and Myotonic Dystrophy patients had at the time they were first informed of their genetic diagnosis Neurology (Adult): Alan Barber - EXTEND-IA: Extending the time for thrombolysis in emergency neurological deficits- intraarterial Richard Roxburgh - Cross section of personality traits in at risk, gene positive and clinically diagnosed patients with Huntington’s Disease Alan Barber- Platelet Oriented Inhibition in New TIA & minor ischaemic stroke (POINT) trial Richard Roxburgh- A Prospective Registry Study in a Global Huntington’s Disease Cohort (Enroll-HD) Peter Bergin - Incidence Study of Status Epilepticus in the Greater Auckland Region Richard Roxburgh - Using genome screening tools including but not limited to whole exome sequencing, whole genome sequencing, genome-wide copy number variation, homozygosity mapping Elizabeth Broadbent- Perceptions about stroke and its impact on daily living Wallace Brownlee- Audit of NMO-IgG antibody testing and cases of neuromyelitis optica in Auckland Winston Byblow - Falling off the curve: The link between impulsivity and dopamine Maurice Curtis- New brain cell production in Huntington’s diseased brains Valery Feigin - Epidemiology of atrial fibrillation in ischaeamic stroke patients: a population based study in Auckland, New Zealand Rita Krishnamurthi- Community outcomes after a bleed (subarachnoid haemorrhage, SAH) in the Brain Gwyn Lewis- The effects of non-invasive brain stimulation on pain, corticomotor excitability, and the nociceptive system in people with neuropathic pain Julie Luker - Exploring the implementation of early rehabilitation for patients with acute stroke Ailsa McGregor - Tolerability of varenicline and feasibility of touchscreen cognitive testing in patients with Huntington’s disease 36 Richard Roxburgh - Prevalence and impact of inherited Myopathies in New Zealand Mark Simpson- Clinical usefulness of the Fog Test for the diagnosis of dystonia Barry Snow - A Randomised, Double-blind, Multi-centre, Phase II, Dose Parallel Study to Determine the Safety and Efficacy of MT10109 (Clostridium Botulinum Toxin Type A) in Subjects with Cervical Dystonia in Comparison to BOTOX® Barry Snow - A Phase I/IIa, Open-label Investigation of the Safety and Clinical Effects of NTCELL [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients with Parkinson’s Disease” Protocol Number LCT/PD-012 Barry Snow - A Phase I/IIa, Open-label Investigation of the Safety and Clinical Effects of NTCELL [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients with Parkinson’s Disease” Protocol Number LCT/PD-012 Cathy Stinear - Accelerating recovery after stroke with neuromodulation: a feasibility study Elizabeth Walker- A Randomized, Double-Blind, PlaceboControlled Study of the Safety and Efficacy of Intranasal Midazolam in the Outpatient Treatment of Subjects with Seizure Clusters Elizabeth Walker - An Open-Label Safety Study of USL261 in the Outpatient Treatment of Subjects with Seizure Clusters Ernest Willoughby - Phase Iib randomised, double-blind, placebo-controlled, dose ranging trial of Vitamin D3 in patients with a first demyelinating event Ernest Willoughby - A dose-frequency blinded, multicenter, extension study to determine the long-term safety and efficacy of PEGylated Interferon Beta-1a (BIIB017) in subjects with relapsing multiple sclerosis Ernest Willoughby - A Double-masked, Placebo-controlled Study with Open label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects with Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders Neurology (Starship): Hannah Jones - Advances in the understanding of autoimmune encephalitides and associated movement disorders in children Cynthia Sharpe - Efficacy of intravenous levetiracetam in the treatment of neonatal seizures, a phase 2 randomised, blinded, controlled treatment trial Neurosurgery: Abhinav Jain - Outcomes of the combined medical and surgical management of Gliosarcoma: 1993-2013 Kathryn Quick - A review of trachesotomy insertion in moderate to severe traumatic brain injury patients at ADHB, including analysis ofthe clinical implications and a comparison to best practice guidelines Newborn: Jane Alsweiler - Immunisation of extremely preterm babies after discharge from the neonatal intensive care unit Jane Alsweiler- Investigating the effects of probiotics on the neurodevelopmental outcomes of preterm infants Jane Alsweiler - Hyperglycaemia and Insulin in Neonates Trial Jane Alsweiler - EYE-SPY, Examining young eyes for signs of prematurity Jane Alsweiler - The use of point of care testing for the measurement of blood glucose concentrations in babies at-risk of neonatal hypoglycaemia Jane Alsweiler - Magnesium for Neuroprotection: Understanding Mechanisms Frank Bloomfield - Does bias gas flow in ventilated preterm babies affect lung injury or the risk of BPD? (the FLORA study) Frank Bloomfield - Multinational survey of nutritional practices in very low birthweight babies (NeoNutriNet Marian Buksh - Multicentre randomised controlled trial of minimally invasive surfactant therapy in preterm infants 2528 weeks gestation on continuous positive airway pressure Cath Conlon- Post discharge nutrition of preterm babies: micronutrient status & feeding practices of preterm babies after hospital discharge Barbara Cormack- PROVIDE: The impact of Protein Intravenous Nutrition on Development in preterm babies. A randomised controlled trial of more intravenous protein in the first week of life Jo Hegarty- A dosing trial to determine the most effective dose and frequency of prophylactic oral dextrose gel in preventing neonatal hypoglycaemia Chuan-Chuan Lan - Follow up management of babies born to hepatitis B positive mothers Wingchi Leung - Current practice of red blood cell transfusion in the neonatal intensive care unit Ed Mitchell - A maternal probiotic intervention for infant allergic disease prevention 37 Newborn: continued Keith Petrie- Can a brief information session reduce the stress levels of mothers of newborns admitted to a high dependency unit? Janine Rouse- Improving patient flow from the Department of Critical Care at Auckland City Hospital to general medical and surgical wards Keith Petrie - Evaluating the psychometric properties of two measures of neonatal pain Older People’s Health: Saul Snowise- The utility of reticulocyte haemoglobin to assess iron availability and anaemia in paediatric dialysis patients Anna Tottman- Long-term neurodevelopmental consequences of neonatal hyperglycaemia and its treatment with insulin Northern Regional Genetics Service: Pauline Elmer-English - An ethnography of children diagnosed with medium-chain acyl-CoA dehydrogenase deficiency (MCADD) Emma Glamuzina - A Long-Term Study for Extended BMN 701Treatment of Patients with Pompe Disease who have Participated in a BMN 701 Study Callum Wilson - Natural history of elevated newborn screening C14.1 in New Zealand Nursing: Jill Clendon - Barriers and facilitators to implementing flexible working hours and career planning for older nurses in the workplace Megan Connolly - Clinical Leadership of Registered Nurses at the point of care in the Emergency Department Annette Dickinson - Medication management in newly graduated nurses: a comparative study between New Zealand and Sweden Meryn Gott - Adapting the views of informal carers (‘VOICES’) questionnaire to the New Zealand context Romana Raby - Nurses’ perceptions of their clinical leadership behaviours at the point of care 38 Geoff Braatvedt - Epidemiology of fragility fracture at Auckland Hospital Roger Harris - Australian and New Zealand Hip Fracture Registry (ANZHFR) Oncology (Adult): Karen Amies - A multicenter, randomized, double-blind, placebo-controlled phase III trial of tecemotide versus placebo in subjects with completed concurrent chemoradiotherapy for unresectable stage III non-small cell lung cancer (NSCLC) Reuben Broom - Dovitinib In 1st-Line Renal Cell Carcinoma, an Investigation into tumour GENe status and Correlation with Efficacy – 1st exploratory study (Diligence-1) Kathryn Chrystal - Retrospective clinical audit investigating the pre-medication regimen used before the drug carboplatin and cisplatin infusions while on a hypersensitivity regimen if gynaecological cancer Kathryn Chrystal- An international phase III randomised trial of dose-fractionated chemotherapy compared to standard three-weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian cancer Kathryn Chrystal - A Randomized, Open Label Study Comparing the Combination of YONDELIS® and DOXIL®/ CAELYX® With DOXIL®/CAELYX® Monotherapy for theTreatment of Advanced Relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Dragan Damjanovic- A randomized, open-label, multicenter Phase IIIb study comparing two trastuzumab dosing regimens, each in combination with cisplatin / capecitabine chemotherapy, as first-line therapy in patients with HER2positive Miriama Delaibatiki - Can IMRT reduce the dose to mandible and hence osteoradionecrosis? Geeta Gala - Faster Cancer Treatment: Pilot of computed tomography colooscopy scanning in the Northern Region Michael Findlay- An internal examination of colorectal cancer management in New Zealand (the PIPER Project) Fritha Hanning - A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours ANZUP, Protocol number: ANZUP 1302 Michael Findlay - A Phase II, Multicentre, Open-Label, Randomized Study Evaluating The Efficacy And Safety of Folfiri + MEDHD7945A Versus Folfiri + Cetuximab In Second Line In Patients With KRAS Wild-Type Metastatic Colorectal Cancer Michael Findlay - Assessment of Overall Survival of FOLFOX6m plus SIR-Spheres microspheres versus FOLFOX6m alone as first line treatment in patients with non-resectable liver metastases from primary colorectal carcinoma in a randomised clinical Study Peter Fong - Phase II single arm, non-randomised, multicentre study to evaluate the efficacy of oral TKI258 as second line therapy in patients with either FGFR2 mutated or wild-type advanced and/or metastatic endometrial cancer (TKI Endo) Peter Fong - A Phase I Study to Evaluate the Safety, Tolerability and Efficacy of SCH900353 in Subjects with Advanced Solid Tumours. Protocol No: PO66203 Peter Fong- A Study in Japan and Ex-Japan to Characterize the Pharmacokinetic and Pharmacodynamic Response to Orteronel (TAK-700) in Chemotherapy-Naïve Patients with Castration-Resistant Prostate Cancer Peter Fong- Genetic analysis of ovarian granulosa cell tumours (GCT) Peter Fong - A Multinational, Phase 3, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Enzalutamide in Patients with Nonmetastatic CastrationResistant Prostate Cancer Peter Fong - A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Rucaparib as Switch Maintenance Following Platinum-Based Chemotherapy in Patients with Platinum-Sensitive, High-Grade Serous or Endometrioid Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer Fritha Hanning - A Phase III Randomized Clinical Trial of Pembrolizumab (MK-3475) versus Paclitaxel, Docetaxel or Vinflunine in Subjects with Recurrent or Progressive Metastatic Urothelial Cancer Nuala Helsby- Observational study of frequency and causes of impaired liver metabolism of cyclophosphamide in breast cancer (LIME) Chakiath Jose - A randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer Han Kim- Patterns of failure in Oropharyngeal carcinoma and whether ipsilateral radiotherapy for lateralised HPV+ tonsillar carcinoma is a viable option of de-scalation George Laking- SCOT – Short Course Oncology Therapy. A study of adjuvant chemotherapy in colorectal cancer Ben Lawrence- Describing the incidence, management and outcomes for patients with Neuroendocrine Tumours in New Zealand (NET Epidemiology) Ben Lawrence- Genomic analyses of neuroendocrine tumour (NET) samples for the development of improved clinical predictors and prognosticators Ben Lawrence - A Randomized, Double-Blind, Phase 3 Study of the JAK1/2 Inhibitor, Ruxolitinib or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic Adenocarcinoma of the Pancreas Who Have Failed or Are Intolerant to First-Line Chemotherapy Ben Lawrence - Generation of patient derived xenografts Dongxu Liu - Artemin as a diagnostic/prognostic biomarker for breast cancer (the ARTN biomarker study) 39 Oncology (Adult): continued Andrew Macann- A Randomized Trial Of Weekly Cetuximab And Radiation Versus Weekly Cisplatin And Radiation In Good Prognosis Locoregionally Advanced HPV-Associated Oropharyngeal Squamous Cell Cancer (OPSCC) Michael McCrystal - GO28141: A phase III double blind placebo controlled study of vemurafenib versus vemurafenib plus GDC-0973 in previously untreated BRAF-V600 mutation positive patients with unresectable locally advanced or metastatic melanoma. Michael McCrystal - Real-World Chart Review Study of Survival Outcomes in Patients with Melanoma who Received Dabrafenib for unresectable (Stage IIIc) and metastatic (stage IV) melanoma as part of the Named Patient Programme (NPP) (compassionate use of Dabrafenib) Mark McKeage- A Phase I/II, Multi-Centre, Open-Label, Dose Escalation Trial of the Safety and Pharmacokinetics of Intravenous PR610 Given Weekly in Subjects with Solid Tumours (Proacta) Mark McKeage- Oncogenic Mutations in Cancer Patients Detected by Sequenom Genotyping: A Prospective Feasibility Clinical Study (ONCOMING study). Mark McKeage- A Phase II, multicentre, single-arm study of oral LDK378 in Crizotinib naive adult patients with ALKactivated Non-small cell lung cancer Mark McKeage- A Phase I, open-label, multicentre, 3-period, fixed-sequence study to investigate the effect of Vemurafenib on the pharmacokinetics of a single dose of acenocomarol in patients with BRAFV600 mutation-positive metastatic malignancy Mark McKeage- A Phase IV, post marketing, open-label, extension (rollover) study of vemurafenib in patients with BRAFV600 mutation-positive malignancies previously enrolled in an antecedent vemurafenib protocol Mark McKeage- An open-label, multi-center Phase 1 dose-finding study of RAD001 (everolimus,Afinitor) in combination with BEZ235 in patients with advanced solid tumours 40 Mark McKeage - A Phase III mutlticentre, randomised study of oral LDK378 versus standard chemotherapy in previously untreated adult patients with ALK rearranged (ALK-positive), stage IIIB or IV, non-squamous non-small cell lung cancer Robert McNeill- Northern Region Lung Cancer Patient and Family/Whanau Evaluation Project Soizick Mesnage- Retrospective audit of patients with BRAF mutation positive metastatic melanoma who have received treatment with dabrafenib Soizick Mesnage- Retrospective audit of patients with muscle invasive bladder cancer treated with neoadjuvant chemotherapy for curative intent Soizick Mesnage - Mapping gastro-oesophageal cancer in the Auckland-Northland region Nicola Mitchell- CEA measurement during adjuvant chemotherapy for colon cancer; does a transient abnormaility impact on overall survival? Nicola Mitchell - Metastatic Renal Cell Cancer: A Multicenter Prognostic Factors Project in the Era of Targeted Therapy David Porter- Clinical audit investigating the changes of practice from a three day oral dexamethasone premedication regimen to a single dose IV (dexamethasone) before the chemotherapy drug docetaxel infusion David Porter - A randomized controlled study of YONDELIS (Trabectedin) or dacarbazine for the treatment of advanced liposarcoma or leiomyosarcoma previously treated with an anthracycline and ifosfamide Lisa Reynolds - Comparing a brief mindfulness intervention with standard relaxation therapy on reducing distress and avoidance behaviour in cancer patients undergoing chemotherapy Emily Ryder- A Multi-Centre Observational Study on the Prevalence of BRAF V600 Mutations in Stage III-IV Melanoma in New Zealand Giuseppe Sasso - Retrospective audit of acute genitourinary toxicity in patients with radical radiotherapy Richard Sullivan - A Randomized, Double-Blind, Phase 3 Study of Docetaxel and Ramucirumab versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small Cell Lung Cancer Following Disease Progression after One Prior Platinum-Based Therapy. Protocol I4T-MC-JVBA© REVEL. Richard Sullivan - A Phase III, Open-Label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of MPDL3280A (Anti-PD-L1 Antibody) Compared With Docetaxel in Patients With Non-Small Cell Lung Cancer After Failure with Platinum-Containing Chemotherapy Richard Sullivan - A Randomized Open-Label Phase III Trial of MK-3475 versus Platinum based Chemotherapy in 1L Subjects with PD-L1 Strong Metastatic Non-Small Cell Lung Cancer Paul Thompson - A non-interventional translational research follow-up study to the VELOUR clinical trial (multicentre international study of aflibercept versus placebo in combination with FOLFIRI for metastatic colorectal cancer) Kirsten van Kessel - Experiences of post-cancer fatigue in New Zealand: a qualitative study Ophthalmology: Riyaz Bhikoo - Primary ocular toxoplasmosis presenting to tertiary referral services Harry Bradshaw- Prevalence of rhegmatogenous retinal detachment (RRD) in patients with myopia in NZ Jennifer Craig - Evaluating outcomes of severe microbial keratitis resulting in admission to Auckland Hospital over the years 2006-2007 and 2013-2014 Shuan Dai - Ten year outcome of laser treatment for retinopathy of prematurity in tertiary centres in New Zealand Paul Donaldson- Identifying targets for the development of anti-cataract therapies Akilesh Gokul - Keratoconus- clinical characteristics, incidence, prevalence and severity amongst the New Zealand population Elissa McDonald - Efficacy and safety of topical corticosteroid compared to placebo in the treatment of bacterial keratitis Charles McGhee - Peripheral ulcerative keratitis and necrotising scleritis in a single centre setting- a retrospective review Charles McGhee - Audit of outcomes of cataract surgery in Auckland Stuti Misra - Ocular biometric parameters prior to cataract surgery Justin Mora- An Epidemiological Investigation of Congenital Eye Anomalies in New Zealand and Australia Andrew Old- Review of visual acuity before and after cataract surgery at Auckland and Waitemata DHBs Dipika Patel - Biometric and biomechanical properties of the eye in health and disease Hussain Patel - The effect of selective laser trabeculoplasty on the intraoccular pressure diurnal variation as measured by the drinking water test Hussain Patel - Demographic analysis of glaucoma in a New Zealand population Jo Sims- Spectrum of uveitis in New Zealand Shuan Dai - Quality Audit of Specialist Nurse Grading of Retinopathy of Prematurity Photographs Jo Sims- Tuberculosis-related uveitis in New Zealand Shuan Dai - Clinical outcome after discharge following ROP screening in the neonatal unit Julia Slark - Exploring the patient experience in Oncology Outpatient. Information, organisation and confidence in care 41 Ophthamology: continued David Squirrell - Investigation of Noncompliance for Diabetic Retinopathy Appointments (INDRA) Michel Neeff - An investigation into the cause of chronic suppurative otitis media Benjamin Thompson- Amblyopia: causes, consequences and rehabilitation Lailade Osunsade - Intracranial sepsis and Sigmoid Sinus Thrombosis Benjamin Thompson- Evaluation of Glaucoma and Ischaemic optic neuropathy as Neurodegenerative Diseases using Structural and Functional Magnetic Resonance Imaging (a pilot study) Hester Taekema Landham - Simulation training for new tracheostomy parents- does it improve self-efficacy and competence Benjamin Thompson - A randomised clinical trial of a new binocular treatment for amblyopiaStructural and Functional Magnetic Resonance Imaging (a pilot study) Orthopaedics (Adult): Simon Thornley - Study of the prevalence of blindness and low vision in New Zealand using the capture recapture method Katherine Annan - Can the outcome of Colles’ Fractures be predicted by initial management: a retrospective analysis of patients treated in Auckland City Hospital Aaron Yap - The detection of choroidal melanoma in the New Zealand population Craig Ball - NZ Rotator Cuff Registry ORL – Head and Neck Surgery: Caitlin Bodian - Audit of the incidence of deep vein thrombosis and pulmonary embolism after joint replacement surgery in 2000 patients Theodore Athanasiadis - Audit of epidemiology and treatment outcomes for recurrent respiratory papillomatosis within the ADHB Andrew Johnston - Allograft-Prosthetic composite graft in the proximal tibia: short term results Elizabeth Broadbent- Patient and Family Coping with Head and Neck Cancer Tadeusz Piszel - Delay of fractured neck of femur surgery due to new anticoagulants (Dabigatran/Rivaroxaban) in Auckland Population Emke van den Broek - In-office bilateral injection laryngoplasty as an adjunctive treatment for recalcitrant puberphonia: a case report and review of the literature Orthopaedics (Starship): Danny Wong - A retrospective case-control study on the use of V1STA Negative Pressure Wound Therapy in the management of Pharyngocutaneous and orocutaneous fistula in patients who have had major head and neck surgery ORL (Starship): Nikki Mills - Prospective descriptive study of infectious aetiology of otitis media and nasopharyngeal bacterial flora of children in New Zealand under changing pneumococcal vaccination schedule 42 Graeme van der Meer - Day Stay paediatric tonsillectomyconfirmation of safety and efficacy in New Zealand John Ferguson - A Retrospective Multicenter Review of Early Onset Spinal Deformity Patients That Underwent Either a Primary or Revision Spinal Bracing Procedure with the Ellipse Technologies MAGEC Spinal Bracing and Distraction System Jillian Lee - Ultrasound in upper limb peripheral nerve injuries: can this affect our surgical decision making? Anna Mackey - Incidental findings on hip surveillance in cerebral palsy Zaid Matti - Outcome of fractures reduced under Ketamin in ED Sarah Murgatroyd - A prospective observational study of current clinical features, microbiologic, radiographic and treatment outcomes of spinal infection Adrienne Socci - Applying a clinical prediction algorithm for differenciating between septic arthritis and transient synovitis in New Zealand Susan Stott - The New Zealand Cerebral Palsy Register Susan Stott - BMI of Paediatric Orthopaedic Patients Susan Stott - The kinematics of inclined walking in children with Cerebral Palsy Nichola Wilson- The Feasibility of outcome measures assessing activity and participation in early recovery from lower limb orthopaedic surgery in children and adolescents with Cerebral Palsy Paediatrics: Cayley Ingham - Patient Satisfaction with the Starship Developmental Paediatrics Outpatient Service Patrick Kelly - Evaluating New Zealand’s first multi-agency for child protection Patrick Kelly - Relationship between known family violence or reports of concern to Child Youth and Family and nonaccidental head injury in children under two years of age Patrick Kelly - Do children admitted to Starship with structural head injury and not referred to Te Puaruruhau (the Starship Child Protection Team) differ from those who are referred, and is there a need to develop referral criteria? Aimee Kettoola - Developmental Screening of Refugee Children under 5 Years Old Arriving in New Zealand (NZ) Diana Lennon - Genetic background of susceptibility to Rheumatic Fever Jonathan Bishop - Surveillance studies undertaken by the New Zealand Paediatric Surveillance Unit Alison Leversha - Rheumatic Fever in WDHB and ADHB: an audit of admissions over 2009-2011 Phillipa Clark - Audit of microarray karyotype testing done on Developmental Paediatric team in 2011- a look at the process from consent to sharing of results Alison Leversha - Streptococcal and Staphylococcal load among primary school children: The impact of a school based health intervention targeting sore throats and skin sepsis Phillipa Clark - What do NZ paediatricians say about services for young people with a dual diagnosis – an internet based survey? Colette Muir - Transition of Medical Care for Young People with Disabilities Cameron Grant - Understanding ICD-9-CM-II coding of emergency department visits for food related allergic reactions. Auckland District Health Board chart review 1988-2011 Cameron Grant - Severe life threatening pertussis in the whole cell and acellular vaccine eras Tori Hayward - How well do we identify developmental problems among preschool children admitted to Starship Children’s Hospital? Lynne Hutchison - Treatment policy in infants with deformational plagiocephaly/brachycephaly: a comparison of beliefs, attitudes and treatment practices between New Zealand and the Netherlands Hilda Mulligan - Participation of children with physical disability in leisure activities in New Zealand Jeanine Nunn - Audit of forensic medical examinations completed by Te Puaruruahau for child and adolescent victims of sexual assault Neerali Parbhu - Paediatric Hospital Experiences: Sprout IV pole evaluatio Jan Sinclair - Randomised placebo controlled study of vitamin D during pregnancy and infancy Mark Taylor - Audit of patient initiated follow up in the general paediatric outpatient department at Starship hospital 43 Paediatric Intensive Care Unit: John Beca - Randomised controlled trial of a combination of Dexamethasone and Adrenaline for Bronchiolitis (DAB Trial) John Beca - The SAFE Extrapolation to Paediatric Intensive Care (SAFE-EPIC) Study John Beca - Sedation and delirium practice in Paediatric Intensive Care Units: Australian and New Zealand Observational Study (Baby Spice) John Beca - Sepsis Prevalence Outcomes and Therapies John Beca - Developmental and functional outcomes in school-age children after neonatal surgery for congenital heart disease Elizabeth Segedin - Epidemiology of Paediatric Chronic Illness in Australia and New Zealand Helen Waldron - PATRONuS- Predicting eArly exTubation after Routine heart Surgery y Pain Services: Deborah Bean - Descriptions of Pain Severity, Disability & Psychological Factors in Chronic Low Back Pain and Complex Regional Pain Syndrome John Beca - Point Prevalence study of Plasma Transfusion Exposure Deborah Bean - electronic Persistent Pain Outcomes Collaboration (ePPOC)- an initiative to support continuous improvement in the quality and effectiveness of pain management in Australasia Anusha Ganeshalingham - The New Zealand Pertussis Experience Malcolm Johnson - The Daily Relationships between Sleep and Pain: A Diary Study Anusha Ganeshalingham - VA ECMO versus conventional therapy in severe paediatric sepsis- a tale of two cities Malcolm Johnson - The temporal relationships between sleep, daily activity and cognitive arousal in insomnia and chronic pain Alistair Gunn - EEG biomarkers of brain injury in newborn babies Jonathan Lillie - Does MRI predict prognosis for children who suffer cardiac arrest prior to PICU. A retrospective review of MRIs and case notes of approximately 70 children who presented to Starship PICU between 2003 and 2012 Katie Moynihan - New Zealand’s national paediatric intensive care transport service. A 10 year review of interhospital retrievals Julie Myers - Fatigue in clinicians who undertake regular aeromedical transport work Gabrielle Nuthall - Observation of multi centre quality improvement project: Improving safety and quality of tracheal intubation practice in paediatric intensive care units and paediatric emergency departments Rebecca Pearce - 7 year retrospective audit of All Terrain Vehicle injuries admitted to Starship Hospital 44 Alex Psirides - Characteristics and outcomes of Medical Emergency Team (MET) call in NZ. A prospective observational study Sarah McCambridge - Addressing intimacy and sexual functioning within a pain clinic. Perspectives from chronic pain patients Jane Thomas - A qualitative survey of chronic pain in adolescents and young people attending the Auckland Regional Pain Service Palliative Care (Adult): Gary Bellamy - Understandings of, and preferences for, Advance Care Planning (ACP) amongst current and future consumers of health care: an exploratory study Merryn Gott - How can the costs of providing care for family and whanau within a palliative care context be appropriately captured for research purposes? Jackie Robinson - Benefits and burdens of hospital admissions for patients with palliative care needs Shamsul Shah – ‘Mens sana in corpore sano’: A sound mind in a healthy body. Healthcare staff’s perceptions of spirituality and spiritual care at Auckland City Hospital Physiology Brooke Cantley - Establishing a reference set for cardiovascular autonomic responses in a local population Kevin Ellyet - Sampling of pulmonary function and cardiopulmonary exercise parameters from a normal New Zealand population Anya Lindsay - Is there a significant difference in parasympathetic/sympathetic tone in bronchial asthmatics that respond positively to a beta-2 agonist compared to non-responsive bronchial asthmatics? Public Health: Michael Hale - Does a pertussis vaccine during pregnancy reduce neonatal infection? Simon Thornley - Is dental caries a risk factor for mortality, and hospital treatment for rheumatic fever, cancer, asthma, pneumonia, middle-ear infection, and behavioural disorders? Alistair Woodward - Are our babies getting bigger? Radiology (Adult): Brendan Buckley - Experience with Cyroablation for treating tumours at ADHB James Caldwell - A retrospective audit of patients presenting to Auckland City Hospital with primary intracerebral haemorrhage James Campbell - A Radiological Study of the anatomy and normal variation of the Tibiofibular interosseous ligament Andrew Holden - Safety and feasibility study of the Shockwave Lithoplasty ™ System Andrew Holden - Prospective, Non-Randomized, SingleArm, Multi-Center, Pharmacokinetic Study for the Treatment of Subjects Presenting with De Novo Occluded/ Stenotic or Re-occluded/Restenotic Lesions of the Superficial Femoral or Popliteal Arteries Using Andrew Holden - MAJESTIC: Stenting of the Superficial FeMorAl and/or Proximal Popliteal Artery proJEct with BoSTon ScientifIC’s Innova drug eluting stent Andrew Holden - ILLUMINATE: ProspectIve, SingLe-Arm, Global MuLti-Centre Study to EvalUate TreatMent of Obstructive SupErficial Femoral Artery and/or Popliteal LesioNs With A Novel PacliTaxel-CoatEd Percutaneous Angioplasty Balloon Andrew Holden - An Evaluation of the 480 Biomedical STANZA Drug-Eluting Resorbable Scaffold (DRS) System in the Treatment of de novo SFA Lesions- The SPRINT Study Andrew Holden - ADVANCE – Clinical Evaluation of the Advance 35 Scoring PTA Balloon Dilatation Catheter Andrew Holden - Safety and Performance Study of the Shockwave LithoplastyTM System Andrew Holden - Prospective, Multicenter Tack Optimized Balloon Angioplasty Below the Knee (TOBA-BTK) study for Infrapopliteal Arteries using the Tack-it Endovascular System Andrew Holden - ZIlver PTX Thumbwheel Delivery System Andrew Holden - Seven centre, physician-initiated, retrospective audit of early experiences with the Nellix device, since commercialisation in March 2013 Andrew Holden - Comparison of QISS versus CEMRA at 3T’ Andrew Holden - A prospective, multi-centre, nonrandomised, single-arm study of the Bard LifeStream Balloon Expandable Vascular Covered Stent in the Treatment of iliac artery occlusive disease (BOLSTER) Andrew Holden - Novel Endovascular Access Trial (NEAT): A Study of the LFEX System for Percutaneous AV Fistula Creation in Haemodialysis Patients 45 Radiology (Adult): continued Andrew Holden - Emba Peripheral Embolization Device (EPED) Study Henry Kwok - The use of multidector CT in the evaluation of non-occlusive mesenteric ischaemia in cardiovascular intensive care patients Martyn Nash - Tracking breast cancer across different imaging modalities using biomechanical models Sahan Wadasinghe - Pelvicaliectasis of pregnancy: defining normal Radiology (Starship): Jules Kieser - Retrospective Analysis of Rib Injury Patterns and Frequency in cases of Non-accidental Injury Ali Mirjalili - Surface anatomy of the sciatic nerve in the gluteal region in the paediatric population Poul Nielsen - Collection of computed tomography (CT) and magnetic resonance imaging (MRI) from human infants for research into Shaken Baby Syndrome and modelling the second stage of labour RehabPlus: Sureshbabu Subramanian - Slow stream rehabilitation; review of outcomes Renal Services (Adult): John Collins - New Zealand Peritoneal Dialysis Registry John Collins - SHARP-ER Study of Heart and Renal Protection- An extension study to SHARP OTA/03/11/116 John Collins - Assessing the benefits of prescribed exercise in clinical populations John Collins - Removal of selected low molecular weight highly proteinbound uraemic toxins in patients on peritoneal dialysis John Collins - The CKD-FIX Study: an investigator-initiated, multicentre, prospective, randomised, double-blind, placebo-controlled; parallel-arm trial testing the hypothesis that compared to placebo 46 Michael Collins - The INTENT trial: The effect of intensive nutrition interventions on weight gain after kidney transplantation- a pilot randomised controlled trial Janak de Zoysa - RITAZAREM: An international, open label, randomised controlled trial comparing rituximab with azathioprine as maintenance therapy in relapsing ANCAassociated vasculitis Ian Dittmer - Outcomes in hepatitis B renal transplant patients Ian Dittmer - A Phase 3, Randomised, Double Blind, Placebo controlled Study of the Efficacy and Safety of FG-4592 for the Treatment of Anemia in Chronic Kidney Disease Patients not on Dialysis, FibroGen Enya Ho - ABO-incompatible live donor kidney transplantation- our experience to date Chun-Yuan Hsiao - To determine incidence, clinical characteristics and outcome of renal transplant recipients with BK viraemia and/or BKV nephropathy in the greater Auckland region between 2008 and 2013 Angela Jackson - Living renal donor transplantation: does local vs regional evaluation impact on patient outcomes Paul Manley - Transplantation and Diabetes (Transdiab): A Pilot Randomised Controlled Trial of Metformin in prediabetes after kidney transplantation Helen Pilmore - New Zealand Survey of Glomerulonephritis Helen Pilmore - SONAR: Study Of Diabetic Nephropathy with Atrasentan. A Randomized, Multicountry, Multicenter, Double-Blind, Parallel, Placebo Controlled Study of the Effects of Atrasentan on Renal Outcomes in Subjects with Type 2 Diabetes Damodara Reddy Thangella - Exploring the Adequacy of Haemodialysis Treatment in Chronic Kidney Patients in Satellite Haemodialysis Units, Auckland District Health Board David Semple - A randomised, controlled trial of low sodium dialysate versus conventional sodium dialysate to reduce left ventricular mass index in patients receiving home haemodialysis: The SOdium Lowering In Dialysate (SOLID) trial David Semple - The genetic causes of renal disease in Aotearoa New Zealand Tonya Kara - Global Assessment of Acute Kidney Injury Incidence and Outcomes: Global Snapshot Elizabeth Stallworthy - End of life care preferences and needs: perceptions of satellite and incentre haemodialysis patients treated by Auckland District Health Board Chanel Prestidge - Audit of imaging peri utetic stent removal post paediatric renal transplant Sarah Tan - Positive complement-dependent cytotoxicity crossmatch live donor kidney transplantation Tina Sun - Inflammatory profile and clinical outcomes associated with Icodextrin ® in a cohort of peritoneal dialysis (PD) patients in Auckland City Hospital Maha Yehia - Percutaneous renal biopsy in high risk patients: complications and alternative literature search Maha Yehia - Supported guideline implementation in a network of peritoneal dialysis units: quality of life assessment sub-study Maria Stack- Genetic basis of Kidney Disease in New Zealand Children William Wong - Thrombotic thrombocytopenic purpura (TTP) Registry William Wong - Clinical and genetic features of Dent’s disease in a NZ pedigree Respiratory Services (Adult): Renal Services (Starship): Tim Christmas - A Phase III, randomized, double-blind, placebo controlled study to assess the efficacy and safety of lebrikizumba in patients with uncontrolled asthma who are on inhaled corticosteroids and a second controller medication Louise Alberella - A retrospective audit of renal function pre and post liver transplantation in New Zealand children with biliary atresia Tim Christmas - Post operative srveillance of NSCLC following resecrion for curative intent- does it offer any benefit to patients? Carol Chan - The follow up and outcome of children requiring renal replacement therapy for acute kidney injury following cardiac surgery Hanna Fontinha - Determining if an association exists between heart rate variability (HRV) and the outcome of saline bronco-provocation and/or exhaled nitric oxide (eNO) testing in asthmatics Sarka Davidkova - The utility of reticulocyte haemoglobin to assess iron availability and anaemia in paediatric dialysis patients Tonya Kara - Retrospective review of paediatric liver transplant patient looking for predictors of renal dysfunction Tonya Kara - A retrospective review of analgesia in paediatric renal transplant recipients Tonya Kara - Examining the health of mother’s with renal transplants in pregnancy and factors that may affect the growth and health of the baby Alaina Francis - Do underwater hockey players show a significant difference in heart rate variability during exposures of hypoxia and hypercapnia compared to normal subjects? Clair King - To examine the relationship between measures of pulmonary function and lung morphology as measured by HRCT in a cohort of elderly subjects Clair King - The diagnostic accuracy of partial sleep studies compared with PSG in an unselected group of attendees to OSA clinics Tonya Kara - Risk Factors for recurrent paediatric focal segmental glomerulosclerosis post transplantation 47 Respiratory Services (Adult): continued John Kolbe - Protocol Gb27980: A Phase Iib, Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy, Safety, And Dosing Regimens Of Memp1972a In Adults With Allergic Asthma Who Are Inadequately Controlled On Inhaled Corticosteroids Tanya McWilliams - A 12-Week Dose-ranging Study to Evaluate the Efficacy and Safety of Fp Spiromax® (Fluticasone Propionate Inhalation Powder) Administered Twice Daily compared with Placebo in Adolescent and Adult Subjects John Kolbe - A multicenter, randomised, blinded, activecontrolled, parallel-group study to compare the efficacy, tolerability and safety of NVA237 compared to tiotropium added on to fluticasone/salmeterol in patients with chronic obstructive pulmonary disease Rachel Vicars - Patient evaluation of CPAP therapy comfort John Kolbe - A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS5806 in Hospitalized Adults with Respiratory Syncytial Virus (RSV) Infection Margaret Wilsher - A randomised controlled trial of conservative versus interventional treatment of primary spontaneous pneumothorax John Kolbe - Long Term Administration of Inhaled Mannitol in Cystic Fibrosis – A Safety and Efficacy Trial in Adult Cystic Fibrosis Subjects John Kolbe - A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pulmaquin® in the Management of Chronic Lung Infections with Pseudomonas aeruginosa in Subjects with Non-Cystic Fibrosis Bronchiectasis, including 28 Day OpenLabel Extension (ORBIT-4) John Kolbe - A phase III, 52 week, randomized, doubleblind, 3-arm parallel group study, comparing the efficacy, safety and tolerability of the fixed dose triple combination FF/UMEC/VI with the fixed dose dual combinations of FF/VI and UMEC/VI, all administered once-daily in the morning via a dry powder inhaler in subjects with chronic obstructive pulmonary disease Christopher Lewis - A review of the ADHB Thoracic Multidisciplinary meeting and the accuracy with which decisions made via this process are translated into patient care Michael Maze - Therapeutic drug monitoring of Rifampicin and Isoniazid at Auckland District Health Board 2005-2012 48 Margaret Wilsher - Correlation between HRCT extent and pattern of disease and pulmonary function tests at 6 and 12 months in newly diagnosed or newly treated sarcoidosis Margaret Wilsher - The association between serial serial HRCT measures and lung function parameters in sarcoidosis Margaret Wilsher - A randomised double blind, double dummy parallel group study to compare the efficacyand safety of fluticasone propionate/formoterol fumarate (flutiform) 500/20ug BID and 250/10ug BID versus salmeterol/fluticasone (Seretide) 50/500ug BID in subjects with chronic obstructive pulmonary disease (COPD) Margaret Wilsher - The clinical utility of chest CT in chronic unexplained cough. Conroy Wong - A Randomised Trial of Tiotropium Treatment for Bronchiectasis Respiratory (Starship): Cass Byrnes - Bronchiectasis Exacerbations Study (BEST) in Australia and New Zealand Cass Byrnes - Azithromycin Bronchiolitis Inteverntional Study 2 Cass Byrnes - A randomised controlled trial of effects of early life exposure to general anaesthesia on neurocognitive and behavioural outcomes in children with cystic fibrosis (CF) Cass Byrnes - A phase 3 multi-centre randomized placebocontrolled study of azithromycin in the primary prevention of radiolgoically-defined bronchiectasis in infants with cystic fibrosis Thomas McNeilly - Use of Cardiovascular risk calculators in patients with Rheumatoid Arthritis Cass Byrnes - COB: Cost of Bronchiectasis Fiona McQueen - DECT to investigate urate deposition in the kidneys in patients with tophaceous gout and its association with renal function Cass Byrnes - Clinical and psychosocial changes over late childhood and adolescence and early life determinants of long term clinical outcomes in cystic fibrosis Fiona McQueen - MRI inflammation as an imaging biomarker in rheumatoid arthritis: monitoring response to the “Treat to Target” approach Steve Heap- The updated UTI Guideline: translating into practice? Simon Otter - A survey of the epidemiology of foot complaints in systemic lupus erythematosus Rheumatology (Adult): Keith Rome- The effect of chronic gouty arthritis on the structure and function of the Achilles tendon Nicholas Cao - Development of the gout recommendation adherence scale: an evaluation of reliability and validity Nicola Dalbeth- Study To Look At How Effective And Safe Lesinurad Plus Febuxostat Is Compared To Febuxostat Alone In People With Gout Who Have Tophi (CRYSTAL) Nicola Dalbeth - Study To Look At How Effective And Safe Lesinurad Therapy Is Compared To Placebo In People With Gout Who Are Unable To Take Standard Therapy (LIGHT) Nicola Dalbeth - Investigation Of Genetic Susceptibility Alleles In Ankylosing Spondylitis, And The Prevalence And Severity Clinical Features Nicola Dalbeth- ACR-EULAR multi-centre, case-control study of classification criteria for gout Nicola Dalbeth - A phase 3 randomised, double blind, multicentre, placebo-controlled, combination study to evaluate the efficacy and safety of Lesinurad and Allopurinol compared to Allopurinol alone in subjects with gout who have had an inadequate hypouricemic response to Nicola Dalbeth - An audit of the safety and efficacy of benzbromarone in the management of gout in New Zealand Keith Rome - Footwear for patients with gout: a feasibility study Keith Rome - Foot and ankle characteristics associated with falls and falls risk in people with rheumatoid arthritis Keith Rome - The clinical effectiveness of footwear in the reduction of pain and disability of people with gout Ravi Suppiah- RITAZAREM: An international, open label, randomised controlled trial comparing rituximab with azathioprine as maintenance therapy in relapsing ANCAassociated vasculitis Ravi Suppiah - New Zealand Vasculitis Study (NZVAS) Vicky Tai - The experience and impact of living with Behcet’s diseases: a qualitative study using the grounded theory method Sexual Health Services: Massimo Giola - Knowledge, attitudes and practices towards viral hepatitis among men who have sex with men attending the Auckland Sexual Health Service; a selfadministered questionnaire to inform future educational, screening and preventive interventions 49 Sexual Health Services: continued Massimo Giola - “Care cascade” audit of viral hepatitis screening and prevention in men who have sex with men (MSM) presenting to the Auckland Sexual Health Service for sexually transmissible infection (STI) screening Susan Jensen - Investigation into anal sex practice and knowledge in a cohort of Heterosexual clients attending at Auckland Regional Sexual Health Service Ian Bissett - In vivo characterisation of pressure wave propagation across healed colorectal anastomoses in patients with long-term post-operative evacuatory dysfunction using high resolution Surgery (Adult): Elizabeth Broadbent - Does written emotional disclosure improve wound healing in surgical patients? Cynthia Benny - Lower gastro-intestinal bleeding: patient characteristics, types of investigation and how this can be applied to a framework for requesting radiological investigations Richard Douglas - p16 as a surrogate biomarker for the presence of Human Papillomavirus (HPV) infections in oropharyngeal squamous cell carcinoma Ian Bissett - Randomised double-blind placebo-controlled trial of gastrografin in the therapeutic management of prolonged postoperative ileus following elective surgery Ian Bissett - In vivo characterisation of large bowel pressure wave propagation in the peri-operative setting and across healed colo-colic anastomoses using a high resolution manometry catheter. Andrew Jo - The diagnosis and management of postappendicectomy intra-abdominal collections Rinki Murphy - The impact of bariatric surgery on diabetic retinopathy progression in those with type 2 diabetes Maxim Petrov - Patient-controlled versus stepwise oral refeeding in acute pancreatitis: A randomised controlled trial Ian Bissett - Clinical factors predicting complete pathological response following neoadjuvant chemoradiotherapy in rectal cancer Maxim Petrov - New insights in relation to risk factors of DM (Diabetes Mellitus) after AP (Acute Pancreatitis) Ian Bissett - Risk factors for the development of Anterior Resection Syndrome following colorectal resection Lindsay Plank - Effect of Preoperative Immunonutrition on Outcome in Patients Undergoing Partial Hepatectomy: A Randomised Pilot Study Ian Bissett - Long-term follow up of renal function following perioperative acute kidney injury: a multi-centre study John Windsor- Redefining the basics: Goal directed fluid therapy in acute pancreatitis Ian Bissett - Early ileostomy closure- a retrospective review and costs analysis John Windsor - Physiological and compositional studies of the human thoracic duct lymph Ian Bissett - A retrospective review of outcomes for admissions with acute diverticulitis (AD) at Auckland City Hospital John Windsor - A review of the computed tomography scans of patients whom have had insertion of a percutaneous drain for necrotizing pancreatitis Ian Bissett - Outcomes following intestinal anastomotic leaks in colorectal surgery John Windsor - Measuring the compartment pressure of the cavity containing pancreatic necrosis following insertion of a percutaneous drain in patients with necrotizing pancreatitis Ian Bissett - Mapping motor activity within the defunctioned ileocaecocolonic segment using high resolution manometry 50 Ian Bissett - Tiger 2 self-advancing nasojejunal tube in adhesive small bowel obstruction – A pilot study to assess feasibility John Windsor - Understanding enteral tube feeding intolerance Surgery (Starship): James Hamill - Validity, Reliability and Responsiveness of a New Multidimensional Location and Level of Intensity of Post-Operative Pain Score (LOLIPOPS) James Hamill - The Children's Interval Appendicectomy (CHINA) study James Hamill - Public campaign for driveway run over prevention 2011/2012: did it work? James Hamill - Sprayed Peritoneal Regional Analgesia in Appendicectomy trial - SPRAY trial James Hamill - Too much TV? Trends in television tip-over trauma at a single trauma centre James Hamill - In New Zealand children, what demographics indicate a predisposition of skin and soft tissue infections? Shareena Lala - Enterobius vermicularis and the paediatric appendix Giorgio Stefanutti - Automated immature granulocyte count (IGC) as a diagnostic test for acute appendicitis in children: a prospective study Kiarash Taghavi- Parathyroidectomy case series Vipal Upadhyay- Paediatric Ovarian Lesions- our experience at Starship Children's Hospital, New Zealand Vipal Upadhyay - Management of paediatric umbilical hernia at Starship Children's Hospital Trauma Service Shanthi Ameratunga - The ‘YourCall’ Study: The effectiveness of text messaging to address hazardous drinking behaviours among admitted trauma patients Ian Civil - Long-term outcomes of TEVAR following traumatic aortic transection in a New Zealand population: What is the optimal strategy for ongoing surveillance? Urology: Vincent Chan - Audit of effectiveness of rectal swab cultures prior to Transrectal ultrasound-guided (TRUS) prostate biopsy Vincent Chong - How effective is hyperbaric oxygen therapy (HBOT) in the treatment of radiation induced cystitis Jonathan Masters- Genetic and genomic technologies, and survival from prostate cancer Jonathan Masters - Is Intravesical BCG Used Effectively In The Greater Auckland Area And What Is The Efficacy? Jim Watson - Clinical validation of the use of different tissue samples in the diagnosis of prostate cancer using multiple RNA biomarker amplicon sequencing Vascular Service: Tom Burton - HbA1c and risk of amputation Andrew Hill - GREAT (Global Registry for Endovascular Aortic Treatment) Registry Andrew Hill - Ethnic Variation in the incidence of Thoracic Aortic Dissection Carl Muthukumaraswarmy - Adoption of EVLT as the primary treatment modality for varicose veins: the Auckland City Hospital Experience Craig Webster - Communication in the Hospital Ward- A Patient-stay Diary Study Gjurgjica Badzakova-Trajkov - An exploration of factors that affect recovery from mild traumatic brain injury and the persistence of post-concussion symptoms 51 Funding for Research In 2012, 2013 and 2014 ADHB researchers and their colleagues have enjoyed considerable success in obtaining funding for their research from public-good sources. 52 A+ Trust Grants A+ Trust Research Grants offer contestable research funding by the Auckland DHB Charitable Trust via a twice yearly competitive round. The aim is to support ADHB researchers from all disciplines and specialties to undertake research across the health spectrum from patients to population, disease to prevention, and service delivery to cost effectiveness and beyond. Applications are externally peerreviewed and assessed by the Research Review Committee for scientific merit, feasibility, rationale and methodology, deliverables, and opportunities to develop the capacity of new researchers in the organisation. The below projects were approved from 2012 through 2014: Projects Jane Alsweiler / Anna Tottman – Newborn- Long-term neurodevelopmental consequences of neonatal hyperglycaemia and its treatment with insulin- $28,400.00 Rohan Ameratunga – Clinical Immunology- Evaluation of Tim-3 as a cellular marker in Immunodeficient patients.- $19,240 Johanna Bannister - Do interventions have a positive impact on women who do disclose partner violence in a health care setting?- $3,810 Kylie Becker / Lindsay Plank – Nutrition Services - Effect of Preoperative Immunonutrition on Outcome in Patients Undergoing Partial Hepatectomy: A Randomised Pilot Study- $9,941 Rachael Bergman – Gastroenterology - Haemorrhage alleviation with tranexamic acid-intestinal system. (Halt-It)- $26,030 Jon Bishop – Paediatric Gastroenterology- Prospective Study to assess validity of the use of serological markers to diagnose Coeliac Disease in New Zealand children according to ESPGHAN diagnostic guidelines- $28,178 Annaliesse Blincoe – Paediatric Immunology- Do Defects in the Innate Immune System Contribute to Non-Cystic Fibrosis Bronchiectasis in Maori and Pacific Island Children? – $30,000 Doug Campbell – Anaesthesia- Neurological Impact of Vascular events In noncardiac Surgery patIents cOhort evaluatioN Study (NeuroVISION)- $30,000 Debra Chalmers – Cardiovascular Intensive Care- A survey of New Zealand public opinion on methods to triage intensive care patients in an influenza pandemic- $30,000 Michael Collins – Renal- Optimal nutrition intervention to prevent excessive weight gain post kidney transplantation: pilot randomised controlled trial- $30,000 Barbara Cormack – Newborn- PROVIDE: The impact of Protein Intravenous Nutrition on Development in preterm babies. A randomised controlled trial of more intravenous protein in the first week of life- $29931 Stuart Dalziel – Children’s Emergency Department- The A-PHIRST study (Australasian Paediatric Head Injury Rules Study): a prospective observational study comparing existing paediatric minor head injury clinical decision rules.- $29,665 Jill Depledge – Women’s Health- The effect of exercise and bracing on the width of the rectus abdomens diastasis in early postnatal women, measured by ultrasound- $29,896 Kerry English – Anaesthesia- Cancelling Elective Surgery: A Mixed Methods Study of the Impact on Quality of Life, Postoperative Outcomes and Patients’ Socioeconomic Standing- $30,000 Cindy Farquhar – Women’s Health- The Intrauterine Insemination (TUI) Study- $25,000 Peter Fong – Oncology- Genetic analysis of ovarian granulosa cell tumours (GCT)- $29,636 Kim Gear – Oral Health- The composition of subgingival plaque bacterial and fungal profiles and their effects on the incidence and severity of oral mucositis in head and neck cancer patients receiving radiotherapy treatment- $29,327 Michael Gillham – Cardiovascular Intensive Care- MicroRNA biomarkers for the early diagnosis of Non Occlusive Mesenteric Ischaemia- $9,453 Devshana Gupta – Women’s Health- Endometrial injury in women with subfertility undergoing IVF/ICSI or expectant management; the Pipelle Injury in Pregnancy (PIP) studies$27,212 James Hamill – Paediatric Surgery- Sprayed Peritoneal Regional Analgesia in Appendicectomy trial- SPRAY trial- $29,994 53 Jo Hegarty – Newborn- A dosing trial to determine the most effective dose and frequency of prophylactic oral dextrose gel in preventing neonatal hypoglycaemia- $29,995 James Houghton – Starship Anaesthesia- The impact of obesity on the pharmacokinetics and pharmacodynamics of propofol infusion in children – A PILOT Study- $30,000 Craig Jefferies - Paediatric Endocrinology- Clinical trial of Zoledronic acid (Aclasta) in children and adolescents with Duchenne muscular dystrophy- $30,000 Peter Jones - Humidified High-Flow Oxygen Therapy in the Emergency Room Study- $30,000 Aimee Kettoola – Paediatric Endocrinology- Developemental screening in refugee children- $16,156 Alison Leversha - Community Child Health and Disability Service- Streptococcal and staphylococcal load among primary school children: the impact of a school based health service targeting sore throats and skin sepsis- $29,912 Alison Leversha – Community Child Health and Disability Service- Streptococcal and Staphylococcal load among primary school children: The impact of a school based health intervention targeting sore throats and skin sepsis- $29,629 David Orr – Gastroenterology- Very low calorie diet (VLCD) followed by fibre and probiotic supplementation is superior to VLCD alone in achieving sustained weight loss and resolution of Non-Alcoholic Fatty Liver Disease-$30,000 Celia Palmer – Palliative Care- A prospective cohort study of tunnelled external peritoneal catheters for the management of malignant ascites- $29,443 Rachael Parke - Cardiovascular Intensive Care Unit- Oxygen therapy in non-intubated patients in the Intensive Care Unit. A bi-national point prevalence study- $11,285 Rachael Parke – Cardiovascular Intensive Care Unit- Is fluid resuscitation pro-inflammatory?- $28,817 Lucy Pemberton – Haematology- A Programme of Development for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome- $30,000 Paul Manly – Renal- Transplantation and Diabetes (Transdiab): A Pilot Randomised Controlled Trial of Metformin in prediabetes after kidney transplantation- $30,000 Naveen Pillarisetti – Paediatric Respiratory- A study of lung microbiome in non-CF bronchiectasis during stability and infective exacerbations compared to healthy children- $29,094 Jonathan Masters – Urology- Genetic and genomic technologies, and survival from prostate cancer.- $29,984 Helen Pilmore – Renal- High Sensitivity troponins in End Stage Renal Failure: Correlations with outcome and changes over time- $29,445 Colin McArthur – Critical Care Medicine- Australasian Resuscitation in Sepsis Evaluation- $17,000 Fiona McQueen – Rheumatology- DECT to investigate urate deposition in the kidneys in patients with tophaceous gout and its association with renal function- $29,707 Justin Mora – Ophthalmology- An Epidemiological Investigation of Congenital Eye Anomalies in New Zealand and Australia- $29,566 Michel Neeff – Paediatric ORL- An investigation of the relationship between the microbiology of chronic suppurative otitis media and the subsequent inflammatory response$30,000 54 Gabrielle Nuthall – Paediatric Intensive Care Unit- Observation of multi centre quality improvement project: Improving safety and quality of tracheal intubation practice in paediatric intensive care units and paediatric emergency departments. NEAR-4-KIDS (National Emergency Airway Registry for Children) - $30,000 Helen Pilmore – Renal- Assessment of Scoring for Renal Transplantation Survival: comparison of methodology and patient perceptions- $30,000 Kathryn Rice – Paediatric Cardiology- Echocardiographic Review of Dynamic Diastolic Function and Preload Markers in Fontan Patients- $27,764 Sally Roberts – LabPlus- Genetic analysis of emerging ceftriaxone resistance among isolates of gonorrhoea- $9,736 Deb Rowe – Neonatal Intensive Care Unit- Needle electrodes for continuous EEG monitoring in the NICU, a prospective study of safety and efficacy- $30,000 Jan Sinclair / Cameron Grant – Paediatric Immunology- Vitamin D status during pregnancy and infancy and the development of atopy- $29,836 Maria Stack – Paediatric Renal- Genetic basis of Kidney Disease in New Zealand Children- $10,000 Peter Stone – Women’s Health- An investigation of the effect of antihypertensives on endothelial activation in preeclampsia - $16,219 Ravi Suppiah – Rheumatology- An international, open label, randomised controlled trial comparing rituximab with azathioprine as maintenance therapy in relapsing ANCAassociated vasculitis- $13,518 Elsa Taylor – Starship Anaesthesia- Parecoxib pharmacokinetics and pharmacodynamis in children- $13,600 Mark Thomas - A Survey of New Zealand Public Concerns about the Ebola Virus- $16,184 Greg Williams – Paediatric Intensive Care Unit- Audit of the new Starship Paediatric Early Warning Score system – Phase I of a Validation and Assessment Programme- $27,100 Deborah Williamson – LabPlus- A prospective observational case-control study of the clinical and molecular epidemiology of skin and soft tissue infections in paediatric patients presenting to Starship Children’s Hospital Auckland, New Zealand- $30,000 Summer Studentships Emme Chacko - Mental Health Services for Older People - Metabolic Side Effects of Atypical Antipsychotics in Older Adults Gary Cheung - Mental Health Services for Older People - Assessing Capacity to Engage in Advance Care Planning in Older People Gary Cheung - Mental Health Services for Older PeopleRoutine assessment of depressive symptoms in older people - the New Zealand experience with interRAI Stuart Dalziel - Children’s Emergency Department- Ibuprofen and Paracetamol in Asthma Causation (iPAC) feasibility study Andrew Hill – Vascular Surgery- Ethnic variation in the incidence of Thoracic Aortic Dissection Kim Jamieson – Anaesthesia- Mastectomy pain audit: Retrospective audit of the incidence of persistent pain >6months post surgery for mastectomy patients Peter Jones – Adult Emergency Department- The Effect of the Shorter Stays in Emergency Departments Health Target on the Quality of Discharge Information Rohit Ramchandra – Physiology- What changes occur in the chemoreceptor reflex during heart failure? Peter Ruygrok – Cardiology- Outcome following heart transplantation in Maori and Pacific Island patients: a comparison with European New Zealanders Peter Ruygrok – Cardiology- Confocal laser scanning microscopy for assessment of cardiac allograft rejection Helen Wihongi – He Kamaka Waiora- Trialling a National Māori review form at the Auckland, Waitematā, and Wellington DHBs Margaret Wilsher – Respiratory Services- The clinical utility of chest CT in chronic unexplained cough Ken Whyte – Respiratory Services- Determination of the arterial blood pressure response to the forced vital capacity maneuver in normal subjects and those with chronic obstructive pulmonary disease 55 Greenlane Research and Educational Fund The Green Lane Research & Educational Fund (GLREF) was started in 1971 at Green Lane Hospital with trustees Alan Kerr, David Hill and Ken Graham, who all made outstanding contributions to treating patients with heart disease. from Cardiology (which at that time was combined adults During the 2013 year, the Fund supported salaries to the and children), Cardiothoracic Surgery, Chest Medicine value of $329,764 (John Neutze Research Scholarship and Cardiac Anaesthesia. Money was raised from patient and secretarial support for this, statistician and desktop donations and occasional gifts and bequests. The Fund administrator), awarded $331,894 in research support now has Trustees from Adult Cardiology, Adult Cardiac and $78,561 in conference support to nurses, technicians Surgery, Paediatric Cardiology and Cardiac Surgery, and other paramedical staff. An additional $65,746 Cardiac Anaesthesia and Intensive Care and Respiratory was released from departmental restricted funds for a Services. Its aims then and now are to support research Transplant Fellowship, research and travel support, and to and education within the departments represented by bring keynote speakers to the Australasian TB Conference trustees, with monthly meetings. Money was raised in held in Auckland. At the Green Lane Dinner the Fund a special initiative by John Neutze when he was head celebrated the exceptional achievements of three former of Cardiology to support a research scholarship (the cardiac anaesthetists, Basil Hutchinson, Donald Stenhouse John Neutze Research Scholarship), and Harvey White and Stuart Kaye. was subsequently appointed in a 5 tenths capacity in During the 2014 year GLREF awarded $1,008,668 which which he has remained. Over the last 12 years the trust was the first time over the $1million mark. It supported has supported a Senior Research Fellowship tenable salaries to the value of $279,646 (John Neutze Research for 3 years, annual large and small project grants on Scholarship and secretarial support for this, statistician a merit contested basis and a 3-year PhD Scholarship. and desktop administrator), awarded research support Applications for conference support are considered 3 of $218,371, two Senior Fellowships totalling $200,000, monthly. The Fund also hosts an annual Scientific Session a Transplant Fellowship of $50,000, a PhD Scholarship followed by the Green Lane Dinner, at which a past valued at $105,000, $65,000 in conference support to member or members’ professional achievements nurses, technicians and other paramedical staff and are honoured. a further $85,651 was released to various projects. A During the 2012 year, the Fund supported salaries to the new scholarship, called the Mornington Brennan Nurses value of $283,970 (John Neutze Research Scholarship Scholarship, valued at $5000 was initiated. At the Green and secretarial support for this, statistician and desktop Lane Dinner the Fund celebrated the achievements of the administrator), awarded $228,150 in research support, Physiology Department represented by Carol Ramage, a PhD Scholarship valued at $105,000 and $75,018 in Donna Aitken, Elaine Rush, Heather Nisbet, Margaret conference support to nurses, technicians and other Vedder, Noel Ashton, Sandy Long and Steve Withy. paramedical staff. At the Green Lane Dinner the Fund 56 celebrated the achievements of three past surgeons, Limited Budget Support Srija Bhattacharyya – Cardiology- High sensitivity troponin T after acute exacerbation of COPD ($10,000) Alaina Francis – Respiratory Physiology- To determine whether significant differences in physiological responses exist between underwater hockey players and healthy controls ($21,460) Mike Gillham – Cardiovascular Intensive Care Unit- To complete a prospective pilot study of novel diagnostic biomarkers in patients with clinically suspected non-occlusive mesenteric ischaemia ($11,457) Clair King – Respiratory Services- Pilot study examining lung function and CT correlates in the ageing lung ($20,000) Shay McGuinness – Cardiovascular Intensive Care UnitContribution to study to assess the safety, feasibility and brain biomarker effect of 24 hours of therapeutic hypercapnia in patients admitted to ICU after cardiac arrest ($10, 275) Peter Ruygrok – Cardiology – Research salary support ($20,000) Jonathon White – Cardiology- A cardiac MRI study understanding troponin elevation in acute exacerbation of COPD ($19,850) Project Support Richard Douglas – ORL- Studies of chronic rhinosinusitis ($69,601) Sarah Fitzsimons – Cardiology- Prevalence of anaemia and iron deficiency in patients with HF-PEF ($29,614) Ghaz Jabur – Clinical Perfusion- Is cerebral autoregulation disrupted by emboli exposure during cardiopulmonary bypass ($48,776) Shay McGuinness - Cardiovascular Intensive Care Unit-Study of the control of oxygen levels during cardio- pulmonary bypass ($80,000) John Ormiston, Mark Webster – Cardiology- Construction of a coronary artery anatomical atlas for PCI ($50,000) Kathryn Rice – Paediatric Cardiology- Dynamic ventricular function in the Fontan circulation ($23,000) Jon Skinner – Paediatric Cardiology- Targeted Next Generation Sequencing to identify the genetic causes of heritable cardiac disorders ($48,882) Tim Willcox – Clinical Perfusion- The Goal Directed Perfusion Trial ($38,000) Margaret Wilsher – Respiratory Services- High flow oxygen therapy in the emergency room ($98,300) Margaret Wilsher – Respiratory Services – The Pneumothorax Study ($42,500) Senior Fellowships Pau Medrano-Gracia - Improving coronary stenting design and patient outcomes ($200,000) Kathryn Waddell-Smith – Paediatric Cardiology- The change in QTc around puberty in long QT syndrome and adherence to beta-blocker therapy ($100,000) PhD Scholarship Kathleen Gilbert - Left and right ventricular function in congenital heart disease ($105,000) June Lau - Simulation based optimization in the Cardiac Intensive Care Unit- optimizing the cardiac surgical patient journey ($105,000) Clair King – Respiratory Services- Correlation of functional and morphological change in the aging lung ($73,466) Cornelis Kruger – Cardiothoracic ORL Anaesthesia- Use of etomidate vs propofol in patients undergoing cardiac surgery ($58,981) 57 Auckland Medical Research Foundation William Abbott – NZ Liver Transplant Unit – Travel Grant Jane Alsweiler, Jo Hegarty – Newborn Services- Oral dextrose gel for prevention of hypoglycaemia in at risk newborn infants ($140,672) Jane Alsweiler – Newborn Services – Travel Grant Rohan Ameratunga, See-Tarn Woon, Wikke Koopmans – LabPlus – Molecular defects in common variable immune deficiency ($54913) Jennifer Weller, Alan Merry – Anaesthesia – Ian Civil – Trauma – Improving team collaboration in the operating room ($123,626) Kathryn Williamson – Newborn Services – Ruth Spencer Medical Research Fellowship- Management of neonatal hyperglycaemia ($257,333) John Windsor – Surgery – Improving the surgical drainage of necrotising pancreatitis ($28,761) Ian Bissett – Surgery – Postoperative gut dysfunction ($63,500) John Windsor – Surgery – Written emotional disclosure and surgery ($151,616) Cho Yui Bob Chan – Dermatology – Sir Harcourt Caughey Award ($25,000) John Windsor – Surgery – Travel Grant Nicola Dalbeth – Rheumatology – Urate and bone ($157475) Stuart Dalziel – Children’s Emergency Department – Australasian Paediatric Head Injury Rules Study (APHIRST) ($114,000) Robert Doughty – Cardiology – The PEOPLE Study ($70,000) Cindy Farquhar – National Women’s Health – The TUI study ($78,500) Fritha Hanning, Peter Fong, Reuben Broom – OncologyAccelerated BEP study, a randomised trial of accelerated versus standard BEP chemotherapy for intermediate and poor-risk advanced germ cell tumours ($56,000) Nigel Lever – Cardiology – Mapping study of persistent atrial fibrillation ($107,426) Don Love, Ivone Leong – LabPlus – Jon Skinner – Paediatric Cardiology- Long QT syndrome and hypertrophic cardiomyopathy gene analysis ($50,000) Soizick Mesnage – Medical Oncology – Sir Harcourt Caughey Award ($25,000) Dipika Patel – Eye Clinic – Travel Grant Janet Rowan – National Women’s Health – Malcolm Battin – Newborn Services – MiG TOFU: 7-9 yr olds ($73,683) Chinthaka Samaranayake – General Medicine – Travel Grant Timothy Short – Anaesthesia – Perioperative vascular events in unrecognised obstructive sleep apnoea ($157,880) Ralph Stewart – Cardiology – Technology and cardiac rehabilitation ($153,003) Andrea Vincent – Eye Clinic – Genetics of anterior corneal dystrophy ($138,968) 58 Tom Wang – Cardiology – Travel Grant Andrew Wood – Paediatric Oncology – Goodfellow Repatriation Fellowship Australian and New Zealand Society of Nephrology Michael Collins – Renal Medicine- Optimal nutrition intervention to prevent excessive weight gain post kidney transplantation: a randomised controlled trial ($10,000) Cancer Society of New Zealand Beth Caudwell – Oncology Research- Auckland Division of the New Zealand Cancer Society Travel Grant awarded Sep 2012 to attend the to attend the Australia New Zealand Gynaecological Oncology Group (ANZGOG) Scientific Meeting in the Gold Coast, Australia 20-23 Mar 2013 ($2240) Kathryn Chrystal – Oncology- Phase II trial of weekly vs 3-weekly chemotherapy, in newly diagnosed ovarian cancer: ICON 8 ($68,273) Christine Crooks – Oncology Research- Auckland Division of the New Zealand Cancer Society Travel Grant awarded Sep 2013 ($2,265) to attend the Australia New Zealand Gynaecological Oncology Group (ANZGOG) Scientific Meeting in Canberra, Australia 26-30 Mar 2014 ($2265) Sophie Goodger – Oncology Research- Auckland Division of the New Zealand Cancer Society Travel Grant awarded Sep 2012 to attend the TROG Annual Scientific Meeting in Wellington, New Zealand 26 Feb – 1 Mar 2013 ($2432) Ashish Joshi – Oncology Research- Auckland Division of the New Zealand Cancer Society Travel Grant awarded Sep 2013 to attend the Australia and New Zealand Breast Cancer Trials Group (ANZBCTG) Study Coordinator Workshop and Annual Scientific Meeting, in Wellington, New Zealand 16-19 Jul 2014 ($1502) Leanne Joss – Haematology Research- Auckland Division of the New Zealand Cancer Society Travel Grant in Mar 2012 to attend the Haematology Society of Australia and New Zealand (HSANZ) branch meeting in Dunedin 22-23 Mar 2012 ($980) Andrew Macann – Oncology- Phase II comparison of two chemoradiation regimes for HPV positive oropharyngeal cancer ($64,406) David Porter – Oncology- SCUBA: Safe Chemotherapy using both Arms ($26,418) Vivian Sun – Oncology Research- Auckland Division of the New Zealand Cancer Society Travel Grant awarded Sep 2013 to attend the World Conference on Lung Cancer in Sydney, Australia 27-30 Oct 2013 ($2556) Jane Wylie – Haematology Research- Auckland Division of the New Zealand Cancer Society Travel Grant in Mar 2012 to attend the Haematology Society of Australia and New Zealand (HSANZ) branch meeting in Dunedin 22-23 March 2012 ($1118) Cardiac Society of Australia and New Zealand Christine Crooks – Oncology Research- Professional Development Award May 2012 to attend the Australia and New Zealand Breast Cancer Trials Group (ANZBCTG) Study Coordinator Workshop and Annual Scientific Meeting, in Hobart, Australia 18-21 Jul 2012 ($2000) Carol Fraser-Browne – Oncology Research- Trust Professional Development Award Dec 2012 to attend the European Society for Radiotherapy and Oncology 2nd International Congress Forum in Geneva, Switzerland, 19-23 Apr 2013 ($3000) Ashish Joshi – Oncology Research- Professional Development Award May 2013 to attend the Australia and New Zealand Breast Cancer Trials Group (ANZBCTG) Study Coordinator Workshop and Annual Scientific Meeting, in Brisbane, Australia 10-13 Jul 2013 ($2,500) Michelle Mulligan – Oncology Research- Professional Development Award Dec 2013 to attend the TROG Annual Scientific Meeting Sunshine Coast, Australia 1-4 Apr 2014 ($3000) Vivian Sun – Oncology Research- Professional Development Award Dec 2012 to attend the Beltas Good Clinical Practice (GCP) Course 19-20 Mar 2013 ($865) Julie Thomas – Oncology Research – Professional Development Award Dec 2013 to attend the Australia New Zealand Gynaecological Oncology Group (ANZGOG) Scientific Meeting in Canberra, Australia 26-30 March 2014 ($2500) Chris Ellis – Cardiology – 2012 Quality of Care Research Grant – 3rd New Zealand Acute Coronary Syndrome Audit Gravida: National Centre for Growth and Development Indran Ramanathan – Cardiothoracic Surgery – 2013 Summer Studentship – Outcomes for patients having repeat tissue valve surgery ($5000) Jane Alsweiler, Frank Bloomfield – Newborn Medical Services - The impact of neonatal hyper- and hypo-glycaemia on the development of the brain ($39,900) Nigel Wilson – Paediatric Cardiology- 2013 Summer Studentship – Defining the disease burden of Rheumatic Heart Disease in the Wellington region ($5000) Frank Bloomfield – Newborn Medical Service- Barbara Cormack – Clinical Dietetics- ProVIDe: The impact of Protein IVN on development. A feasibility study ($39,515) Genesis Oncology Trust Frank Bloomfield, Jane Alsweiler – Newborn Medical Service – Barbara Cormack – Clinical Dietetics- Metabolic Outcome with High Protein Intakes in Preterm Babies ($521,985) Beth Caudwell – Oncology Research- Professional Development Award May 2012 to attend the Australasian Gastro-Intestinal Trials Group Annual Scientific Meeting in Sydney, Australia 6-8 Sep 2012 ($2000) Frank Bloomfield - Newborn Medical ServicesPericonceptional programming of adult adipose tissue inflammation and insulin resistance ($30,000) 59 Frank Bloomfield – Newborn Medical Service- Life as a twin begins at conception ($764,333) Frank Bloomfield – Newborn Medical service- Eating patterns in Maori preschool children ($340,623) Katie Groom – National Women’s Health - Frank Bloomfield, Jane Alsweiler – Newborn Medical Service – Barbara Cormack – Clinical Dietetics- The development of a national multicentre perinatal clinical trials network – a feasibility study ($40,000) Health Research Council of New Zealand William Abbott – NZ Liver Transplant Unit - Prediction of Serious Liver Inflammation in Chronic Hepatitis B Virus Infection ($174,386) Peter Bergin- Neurology- Clinical Practitioner Research Fellowship- Use of the EpiNet platform for clinical trials and epidemiological studies in epilepsy ($905,000) Peter Bergin – Neurology- Incidence Study of Status Epilepticus in the Greater Auckland Region ($671,782) Frank Bloomfield, Jane Alsweiler – Newborn Medical Services – Perinatal Care and its Long-term Consequences ($3,622,591) Stuart Dalziel – Children’s Emergency Department – RCT of levetiracetam vs phenytoin for status epilepticus in children (CONSEPT) ($1,198,985) Stuart Dalziel – Children’s Emergency Department- Clinical Practitioner Research Fellowship – Paediatric Emergency Research ($766,067) 60 The EpiNet project Dr Peter Bergin A problem bedevilling research in epilepsy is that the condition is very diverse and often of unknown cause. Drug companies tend to focus on more common forms and it is very difficult to organise the required number of study sites to get an adequate sample size of people with a particular condition by conventional means. Dr Bergin is an Auckland City Hospital epileptologist who over the past six years has developed an electronic, web-based platform for conducting clinical trials in epilepsy. Any specialist in epilepsy, appropriately qualified, would be able to enrol an eligible patient in an EpiNet trial from anywhere in the world. This has the potential to speed international research in epilepsy. Dr Bergin has already achieved much by way of proving the concept with a number of small grants and has recently had a significant boost when the Health Research Council agreed to personal funding for Dr Bergin to continue this work. The HRC awarded a five-year Clinical Practitioner Fellowship which will enable him to further focus on this for five years. He is one of only six people in New Zealand to have received one of these grants. The EpiNet study group is currently planning a series of trials in new-onset epilepsy. Patients who have not previously been treated with an antiepileptic drug will be randomised to receive either levetiracetam, sodium valproate, carbamazepine or lamotrigine, depending on the seizure type and suitability of valproate. These studies are being funded by the Neurological Foundation of New Zealand. Dr Peter Bergin Colin McArthur – Critical Care Medicine – Randomised trial of hydrocortisone in critically ill patients with septic shock ($773,854) Colin McArthur – Critical Care Medicine – Standard issue transfusion versus fresher red blood cell use in intensive care ($775,723) Colin McArthur – Critical Care Medicine – RCT of continuous versus intermittent beta-lactam antibiotics in the critically ill ($213,894) Colin McArthur – Critical Care Medicine- Early goal-directed sedation in mechanically ventilated intensive care patients ($1,118,620) Shay McGuinness – Cardiovascular Intensive Care – Permissive Hypercapnia, Alveolar Recruitment and Limited Airway Pressure in ARDS ($320,960) Leukaemia and Blood Cancer New Zealand National Research Grant Lucy Pemberton – Haematology- AML LI1 trial: A programme of development for older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome ($120,000) Mercia Barnes Trust, Royal Australia and NZ College of Obstetrics and Gynaecology Katie Groom – National Women’s Health – Frank Bloomfield – Newborn Services- The development of a national multicentre perinatal clinical trials network – a feasibility study. ($20,000) National Heart Foundation Shay McGuinness - Cardiovascular Intensive Care Unit - Restrictive vs. Liberal Fluid Therapy in Major Abdominal Surgery- The RELIEF study ($770,667) Ivone Leung – LabPlus- Purchase of equipment for targeted and whole exome sequencing to identify the genetic causes of long QT syndrome ($15,000) Shay McGuinness - Cardiovascular Intensive Care Unit- Study of the Control of Oxygen levels during cardiopulmonary bypass ($141,411) Don Love – LabPlus- Mutation screening of cardiac genes in Sudden Unexpected Death in the Young (SUDY) andSudden Infant Death Syndrome (SIDS) patients ($126,048) Claire McLintock – National Women’s Health – A national population-based study of rheumatic heart disease in pregnancy ($148,910) Ralph Stewart – Cardiology- Evaluation of frailty and comorbidity in patients with severe heart disease ($150,000) Rachael Parke – Cardiovascular Intensive Care – Fluid therapy after cardiac surgery – a feasibility study ($137,356) Tim Short – Anaesthesia – The influence of anaesthetic depth on patient outcome after major surgery ($1,199,005) Ralph Stewart – Cardiology- Evaluation of frailty and comorbidity in patients with ischemic heart disease ($350,000) Ralph Stewart – Cardiology – Clinical Practitioner Research Fellowship- Registry based clinical trials ($800,000) Harvey White – Cardiology- Cost effectiveness of fractional flow reserve in myocardial infarction ($350,000) Nigel Wilson – Paediatric Cardiology – The significance of rheumatic heart disease detected by echocardiography ($800,000) Kathryn Waddell-Smith – Paediatric Cardiology – The Clinical Cardiology Fellowship in Inherited Heart Disease Tom Wang – Green Lane Cardiovascular Service- National Heart Foundation Travel Grant – European Society of Cardiology Congress, Amsterdam 2013 ($3500) Neurological Foundation of New Zealand Peter Bergin – Neurology- Randomised controlled trials of patients with new onset epilepsy; EpiNet-First ($157,686) Douglas Campbell – Anaesthesia- Neurological Impact of Vascular events In non-cardiac Surgery patIents cOhort evaluatioN Study, (NeuroVISION) ($171,530) New Zealand Breast Cancer Foundation Maria Pearse – Oncology – funding for a Research Fellow to evaluate specific breast cancer projects using the data in the Auckland Breast Cancer Study Group database and to undertake laboratory research in breast cancer genomics ($113000) 61 New Zealand Society of Gastroenterology Alex Lampen-Smith – NZ Liver Transplant Unit- Future care preferences in patients with Child-Pugh C cirrhosis ($5,000) David Orr– Gastroenterology- Very low calorie diet (VLCD) followed by antibiotic and prebiotic supplement is superior to VLCD in achieving sustained weight loss and resolution of NAFLD Application ($5,000) The Nurture Foundation for Reproductive Research Frank Bloomfield – Newborn Services- Protein IVN: Impact on Development ($10,055) Pritchard Coutts Charitable Trust Nigel Patton – Haematology- UKALL4: A randomized trial for adults with newly diagnosed acute lymphoblastic leukaemia ($53,500) Trans Tasman Radiation Oncology Group Dee Yang – Oncology Research- Trans-Tasman Radiation Oncology Group (TROG) Conference Scholarship awarded Jan 2013 to attend the TROG Annual Scientific Meeting in Wellington, New Zealand 26 Feb – 1 Mar 2013 ($1400) 62 Promoting Research at Auckland DHB Research Events for Auckland DHB Celebration Week Research Posters ADHB Celebration Week (final week of November) was the occasion, and ACH Level 5 Atrium was the venue, for the 2012, 2013 and 2014 Research Poster Competitions displays. Continuing the success of previous years, over 60 posters were on display every year, showcasing the commitment of our staff to research, and our expertise across a diverse range of disciplines and topics. Winners for the three judging categories are below. Health Professions Promoting Research (Allied, Scientific, Technical) 2012 Winner – Stella Lai, Diagnostic Genetics, LabPlus, “Next Generation Sequencing approach and its use in BRCA testing” 2013 Winner – Indira Basu, Department of Microbiology, LabPlus, “Genotype characterization of multi-drug resistant Mycobacterium tuberculosis isolates in New Zealand 2002-2012” 2014 Winner – Jill Faulkner, Microbiology, LabPlus, “Homograft heart valve implantation culture results January 2007 to April 2013” 63 Medical Nursing 2012 Winner – Reuben Broom, Medical Oncology, “RAD001 and zoledronic acid in renal cell carcinoma patients with bone metastases (RAZOR): A randomized phase II trial” 2012 Winner – Nancy Naea, Community Child health & Disability Service, Child & Youth Health Team, “Pacific people’s awareness and understanding of Rheumatic Fever” 2013 Winner – Cindy Farquhar, Women’s Health, “A randomized controlled trial of fallopian sperm perfusion compared with standard intrauterine insemination for women with non-tubal infertility” 2014 Winner – Tom Wang, Cardiology, “Atrial fibrillation independently predicts short and long-term mortality after aortic valve replacement” 2013 Winner – Karen Schimanski, Adult Emergency Department and Assessment and Planning Unit, “Comparison of the Left Upper Arm and Forearm Non-invasive Blood Pressures in Adult Emergency Department Patients: A Randomised Cross-over Trial” 2014 Winner – Lianne McCarthy, Cardiovascular Intensive Care Unit, “A Randomised Controlled Trial Investigating the Effectiveness of Self-administered Methoxyflurane for the Removal of Post Cardiac Surgery Chest Drains” Auckland DHB Young Investigator Award The quality and impact of research undertaken by our junior clinical staff was also highlighted with the oral presentations for the Young Investigator Award, 2012, 2013 and 2014. Each year five outstanding candidates were selected by a multidisciplinary panel. The Physicians Grand Rounds, held in the Fisher and Paykel Clinical Education Centre in 2012 and 2013 and in the University of Auckland Grafton Campus in 2014, were attended by a large number of staff both past and present to hear the finalists’ presentations, which are listed below. Winners received $1000 Travel Prizes, funded by the A+ Trust. 2012 finalists Matthew Boyle, Department of Orthopaedic Surgery, Starship Children’s Hospital; Is ankle syndesmosis screw removal required? A prospective, randomised, controlled trial Tom Wang, Green Lane Cardiovascular Service, Auckland City Hospital; Utility of high-sensitivity troponin after coronary artery bypass grafting: characteristics and outcomes of type 5 myocardial infarction Mary De Almeida, Department of Microbiology, LabPlus; Clostridium difficile infection (CDI) due to the emergence of a new hypervirulent strain, PCR-ribotype 244, in New Zealand Garalynne Binford, Regional Eating Disorders Service; Normalised Eating in the Treatment of Eating Disorders Laura-Clare Whelan, Paediatric Intensive Care Unit; A pilot study investigating the use of heated humidified oxygen and dry oxygen therapy in children with acute respiratory illness Matthew Boyle was judged the winner and Mary De Almeida the runner-up. 2013 finalists Tom Wang, Green Lane Cardiovascular Service, Auckland City Hospital; Comparison of four contemporary risk scores for predicting mortality and morbidity after aortic valve replacement Ben Albert, Paediatric Endocrinology and Diabetes, Starship Children’s Hospital; Neurodevelopmental outcomes in children with congenital hypothyroidism treated with high-dose initial replacement and close monitoring 64 Janarthanan Sathananthan, Interventional Cardiology; How many dialysis patients receive transplantation after achieving eligibility by undergoing coronary artery bypass grafting? Kaitlin Fahey, Physiotherapy, RehabPlus; Should Elective Spinal Surgeries be placed on the Physiotherapy Weekend Roster? 2013 finalists continued Chris Cederwall, New Zealand Liver Transplant Unit; Retrospective comparison of Radiofrequency and Microwave ablation for Hepatocellular Carcinoma Tom Wang was judged the winner and Ben Albert the runner-up. 2014 finalists Ghaz Jabur, Green Lane Clinical Perfusion, Auckland City Hospital; Integrated arterial filters in new generation oxygenators: do they cut the mustard? 2013 YIA Winner Tom Wang Kylie Russell, Nutrition Services; Effect of Preoperative Immunonutrition on Outcome in Patients Undergoing Liver Resection: A Randomised Pilot Study Leesa Pfeifer, Auckland Diabetes Centre; Modelling Alternative Diabetic Ketoacidosis Management Protocols Suggests TwoHourly Blood Glucose Sampling Overnight Is Safe Nicky Lawrence, Medical Oncology; Does endocrine therapy in mucinous and tubular breast cancer improve outcomes? Nick Gow, LabPlus; The role of echocardiography in Staphylococcus aureus bacteraemia at Auckland City Hospital Kylie Russell was judged the winner and Nick Gow the runner-up. 2014 Young Investigator winner Kylie Russell with Auckland DHB Chief Medical Office, Dr Margaret Wilsher, and Dean of the Faculty of Medical and Health Sciences, University of Auckland, Professor John Fraser. Children’s Research Centre Award Generously funded by the Starship Foundation, and judged by the Children’s Research Centre Advisory Committee, this award is to assist staff of Starship Children’s Health to attend a conference and present the findings of their project. The 2012 winner was Laura-Clare Whelan, Staff Nurse, Paediatric Intensive Care Unit, Starship Children’s Hospital, for her oral presentation entitled “The Heated Humidification Study: A pilot study investigating the use of heated humidification of low flow oxygen in children” at the 4th Congress of the European Academy of Paediatric Societies 2012, October 5-9 2012 Istanbul, Turkey. Wendy Yu, Department of Paediatric Surgery and Urology, Starship Children’s Hospital, was the runner up. The 2013 winner was Rebecca Walker, Department of Paediatrics, University of Auckland. Rebecca gave a poster presentation entitled “Risk factors for chronic otitis media with effusion in Auckland children aged 3-5 years: a case-control study” at the 7th Extraordinary International Symposium on Recent Advances in Otitis Media – Stockholm- Sweden- June 12th-16th 2013. 65 Honours & Awards Of those conducting research at ADHB, many received honours and invitations to showcase their accomplishments from 2012 to 2014. While this list is not exhaustive, we are pleased to congratulate our researchers for the following achievements. 66 Awards and Prizes Ben Albert – Paediatric Endocrinology – 2013 Asia Pacific Paediatric Endocrine Society Kaichi Kida Award Kitty Bach – Newborn Services – Nominated in 2012 for the University of Auckland Vice-Chancellor’s Prize for Best Doctoral Thesis Reuben Broom – Adult Oncology – Australian and New Zealand Urogenital and Prostate Cancer Trials Group 2012 Annual Scientific Meeting – Best Oral Abstract Presentation 2012 for: RAD001 and zoledronic acid in renal cell carcinoma patients with bone metastases (RAZOR) – a randomised phase II trial. John Collins – Renal Medicine - Kidney Health Australia Best Clinical Science award at 2012 Australian and New Zealand Society of Nephrology annual scientific meeting Anthony Doyle – Radiology - RANZCR NZ Education Trust Prize 2012 and Rouse Travelling Fellowship 2013 Ed Gane – NZ Liver Transplant Unit – 2014 Health Research Council of New Zealand Liley Medal Abbey Jebb – Oncology - Young Investigator Prize - 4th National Lung Cancer Conference, Auckland NZ, March 2012. An audit of cisplatin and vinorelbine use and tolerability for patients receiving adjuvant treatment of non-small cell lung cancer Margaret Joppa – Oncology Research - 2013 PPD Excellence Award in recognition of her contribution to the first interim analysis for the C21005 Prostate Cancer Study Alex Lampen- Smith – NZ Liver Transplant Unit – 2013 Gilead Young Investigators Award – Liver, NZ Society of Gastroenterology Tien Huey Lim – NZ Liver Transplant Unit – 2012 Roche Young Investigators Award – Hepatology, NZ Society of Gastroenterology David Orr – NZ Liver Transplant Service – 2012 and 2013 NZSG-Ferring Research Fellowship, NZ Society of Gastroenterology Maggie Ow – Gastroenterology – Abbvie Best Hepatology Paper/Poster at the New Zealand Society of Gastroenterology Conference 2014 RadioHUM trial presentation – Radiation Oncology – at the Royal Australia and New Zealand College of Radiology Annual Scientific Meeting, Auckland, Oct 2013, Chris Atkinson Award for best Radiation Oncology scientific paper presentation, Elekta Award for best Radiation Oncology oral presentation advancing the use of technology and the NZ Radiology Education Trust Prize for the best proffered paper in Radiation Oncology Tom Wang – Cardiology – 2012 Cardiac Society of Australia and New Zealand Young Investigator Award, 2013, Royal Australasian Society of Surgeons Congress Young Investigator Award (Cardiothoracic Surgery) and ADHB Young Investigator Award 67 Health Research Council of New Zealand’s Liley Medal awarded for Hepatitis C breakthrough Auckland District Health Board hepatologist and liver transplant specialist Professor Ed Gane received the Health Research Council of New Zealand’s distinguished Liley Medal in 2014 for demonstrating a safer, more effective treatment for people with hepatitis C virus. The Liley Medal is presented annually to a recipient whose research publication has made a significant contribution to health and medical science. The 2014 Liley Medal recognises Professor Gane’s outstanding contribution to the health and medical sciences in the field of clinical hepatology. Professor Gane was the lead author on two very highly cited papers in the prestigious medical journal, New England Journal of Medicine, which showed that people could be cured of the hepatitis C virus in just 12 weeks using an antiviral treatment called sofosbuvir. “Less than 1 per cent of New Zealanders infected with hepatitis C are treated each year because the current treatment, which uses interferon, is not very effective and is poorly tolerated,” says Professor Gane. Professor Ed Gane Interferon occurs naturally in the human body. When extra quantities of it are injected into the body, the immune system is stimulated to fight off hepatitis C. Unfortunately, because interferon is given by weekly injections at a much higher dose than what the body produces naturally, it can cause many adverse side effects. The antiviral treatment successfully developed and tested by Professor Gane has become the first interferon-free treatment for people with hepatitis C infection. “Hepatitis C virus has become the global and silent epidemic of this century, affecting more than 180 million people. Here in New Zealand, almost 50 per cent of adult liver transplants are for hepatitis C virus-related liver failure,” says Professor Gane. “Hepatitis C virus has now overtaken hepatitis B virus as the leading cause of liver cancer.” “Even in infected individuals who never develop cirrhosis, hepatitis C virus infection is often associated with fatigue and reduced quality of life.” The HRC’s Acting Chief Executive, Dr Tania Pocock, says Professor Gane’s studies have been instrumental in helping to develop safer, more effective and better tolerated therapies for hepatitis C virus that are of short duration. “The impact of this research is substantial due to the high prevalence of the disease worldwide and the relatively simple treatment developed and tested by Professor Gane,” says Dr Pocock. (Courtesy of Health Research Council of New Zealand) 68 Appointments to Professional Societies, Colleges, Advisory Boards, Committees. Professor Peter Ruygrok Frank Bloomfield – Newborn Services- 2013 Guest Professor, Chongqing Medical University, Chongqing, People’s Republic of China, Guest Professor, Medical University of Kunming, Kunming, People’s Republic of China, appointed to Ministry of Health National Maternity Monitoring Group, 2012 appointed as an Editor, Pediatric Research Ed Gane – NZ Liver Transplant Unit -2013 University of Auckland Honorary Professor Inaugural Lecture James Pemberton – Cardiology – 2012 Fellowship of the American Society of Echocardiography (FASE) Peter Ruygrok – Cardiology - 2013 University of Auckland Honorary Professor Inaugural Lecture Ralph Stewart – Cardiology - 2013 University of Auckland Honorary Professor Inaugural Lecture Professor Ralph Stewart 69 Publications 70 Abbott, A.L., Adelman, M.A., Alexandrov, A.V., Barber, P.A., Barnett, H.J.M., Beard, J. et al. Why Calls for More Routine Carotid Stenting Are Currently Inappropriate: An International, Multispecialty, Expert Review and Position Statement. (2013) Stroke, 44, pp.1186-1190. Abbott, W.G.H., Tsai, P., Ross, H.A., ‘Ofanoa, M., Trevarton, A.J., Hornell J., Munn S.R., Gane E.J. Selection Pressure on the Hepatitis B Virus Pre-S/S and P Open Reading Frames in Tongan Subjects with a Chronic Hepatitis B Virus Infection. (2012) Antiviral Research, 96, pp. 148-157. Abizaid, A., Ormiston, J.A., Fajadet, J., Mauri, L., Schofer, J., Verheye, S., Dens, J., Thuesen, L., Macours, N., Qureshi, A.C., Spaulding, C. Two-year follow-up of the NEVO RESELUTION I (NEVO RES-I) trial: a randomised, multicentre comparison of the NEVO sirolimus-eluting coronary stent with the TAXUS Liberté paclitaxel-eluting stent in de novo native coronary artery lesions. (2013) EuroIntervention, 9(6), pp. 721-729. Abdul-Kadir, R., McLintock, C., Ducloy, A.-S., El-Refaey, H., England, A., Federici, A.B., Grotegut, C.A., Halimeh, S., Herman, J.H., Hofer, S., James, A.H., Kouides, P.A., Paidas, M.J., Peyvandi, F., Winikoff, R. Evaluation and management of postpartum hemorrhage: Consensus from an international expert panel. (2014) Transfusion, 54 (7), pp. 1756 - 1768. Abdul Uloom, M.A. A rare case of massive systemic embolisation secondary to atrial myxoma- case report. (2013) Medical Journal of Malaysia, 68 (6), pp. 471 - 472. Abumaree, M.H., Chamley, L.W., Badri, M., ElMuzaini, M.F. Trophoblast debris modulates the expression of immune proteins in macrophages: A key to maternal tolerance of the fetal allograft? (2012) Journal of Reproductive Immunology, 94 (2), pp. 131-141. Ackerley, S.J., Stinear, C.M., Barber, P.A., Byblow, W.D. Priming sensorimotor cortex to enhance task-specific training after subcortical stroke. (2014) Clinical Neurophysiology, 125 (7), pp. 1451 - 1458. Adelson, P.D., Wisniewski, S.R., Beca, J., Brown, S.D., Bell, M., Muizelaar, J.P., Okada, P., Beers, S.R., Balasubramani, G.K., Hirtz, D. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): A phase 3, randomised controlled trial. (2013) The Lancet Neurology, 12 (6), pp. 546-553. Adlbrecht, C., Huber, K., Reynolds, H.R., Carvalho, A.C., Džavík, V., Steg, P.G., Liu, L., Marino, P., Pearte, C.A., Rankin, J.M., White, H.D., Lamas, G.A., Hochman, J.S. Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction. (2014) International Journal of Cardiology, 174 (1), pp. 90 - 95. Allegaert K., Anderson B., Simons S., van Overmeire B. Paracetamol to induce closure of the patent ductus arteriosis: another hype or is it real? (2013) Arch Dis Child, 98, pp. 462-466. Ady Wirawan, I.M., Larsen, P.D., Aldington, S., Griffiths, R.F., Ellis, C.J. Cardiovascular risk score and cardiovascular events among airline pilots: A case-control study. (2012) Aviation Space and Environmental Medicine, 83 (5), pp. 465-471. Allegaert K., Vanhaesebrouck S., Naulaers G., Anderson B.J. The paracetamol concentrationeffect relation in neonates. (2013) Pediatr Anesth, 23, pp. 45-50. Ahmed, J., Smith, W.M., Ruygrok, P.N., Occleshaw, C. Right ventricular morphology on catheter angiography: Variations and its implications for the diagnosis of arrhythmogenic right ventricular cardiomyopathy. (2012) Heart Lung and Circulation, 21 (11), pp. 700-705. Aikman, K.L., Hobbs, M.R., Ticehurst, R., Karmakar, G.C., Wilsher, M.L., Thomas, M.G. Compliance with guidelines for antimicrobial therapy for community acquired pneumonia, at Auckland Hospital, New Zealand. (2013) Journal of Pharmacy Practice and Research, 43 (4), pp. 272-275 Alagna, L., Park, L.P., Nicholson, B.P., Keiger, A.J., Strahilevitz, J., Morris, A., Wray, D., Gordon, D., Delahaye, F., Edathodu, J., Miró, J.M., FernándezHidalgo, N., Nacinovich, F.M., Shahid, R., Woods, C.W., Joyce, M.J., Sexton, D.J., Chu, V.H. Repeat endocarditis: Analysis of risk factors based on the International collaboration on endocarditis - Prospective cohort study. (2014) Clinical Microbiology and Infection, 20 (6), pp. 566 - 575. Allegaert K, Olkkola KT, Owens KH, van de Velde M, de Maat MM, Anderson BJ. Covariates of intravenous paracetamol pharmacokinetics in adults. (2014) BMC Anesthesiol, 14, p. 77. Allen, S.J. Fluid therapy and outcome: Balance is best. (2014) Journal of Extra-Corporeal Technology, 46 ( 1 ), pp. 28 - 32. Allen, S.J. Gastrointestinal complications and cardiac surgery. (2014) Journal of ExtraCorporeal Technology, 46 (2) pp. 142 - 149. Al-Murrani, A., Ashton, F., Aftimos, S., George, A.M., Love, D.R. Amino-terminal microdeletion within the CNTNAP2 gene associated with variable expressivity of speech. (2012) Case Reports in Genetics, 172408. Alpert, J.S., Thygesen, K.A., White, H.D., Jaffe, A.S. Diagnostic and therapeutic implications of type 2 myocardial infarction: Review and commentary. (2014) American Journal of Medicine, 127 ( 2 ), pp. 105 - 108 . Alsweiler, J.M., Harding, J.E., Bloomfield, F.H. Tight glycemic control with insulin in hyperglycemic preterm babies: a randomized controlled trial. (2012) Pediatrics, 129, pp. 639-647. Alawami, M., Wasywich, C., Cicovic, A., Kenedi, C. A systematic review of clozapine induced cardiomyopathy. (2014) International Journal of Cardiology, 176 (2), pp. 315 - 320. Alsweiler, J.M., Harding, J.E., Bloomfield, F.H. Neonatal hyperglycaemia increases mortality and morbidity in preterm lambs. (2013) Neonatology, 103, pp. 83-90. Albert, B.B., Eckersley, L.G., Skinner, J.R., Jefferies, C. QT prolongation in a child with thyroid storm. (2014) BMJ Case Reports. Ameratunga, R. Gluteal subcutaneous atrophy after depot steroid injection for allergic rhinitis. (2012) World Allergy Organ J, 5 (11), pp.168-169. Alherbish, A., Westerhout, C.M., Fu, Y., White, H.D., Granger, C.B., Wagner, G., Armstrong, P. The Forgotten Lead: Does aVR ST-deviation add insight into the outcomes of ST-elevation myocardial infarction patients? (2013) American Heart Journal, 166(2), pp. 333-339. Ameratunga R, Brewerton M, Slade C, Jordan A, Gillis D, Steele R, Koopmans W, Woon ST. Comparison of diagnostic criteria for common variable immunodeficiency disorder. (2014) Front Immunol, 5, p. 415. Alkindi, S., Battin, M., Aftimos, S., Purvis, D. Focal dermal hypoplasia due to a novel mutation in a boy with klinefelter syndrome. (2013) Pediatric Dermatology, 30 (4), pp. 476-479. Ameratunga, R., Casey, P., Parry, S., Kenedi, C. Hypogammaglobulinemia factitia- Munchausen syndrome masquerading as common variable immune deficiency. (2013) Allergy Asthma Clin Immunol, 9 (1), p. 36. 71 Ameratunga R, Chen CJ, Koopmans W, Dunbar PR, Brewerton M, Lloydd R, Mansell CJ, van Vliet C, Woon ST. Identification of germinal centres in the lymph node of a patient with hyperimmunoglobulin M syndrome associated with congenital rubella. (2014) J Clin Immunol., 34 (7), pp. 796-803. Ameratunga R, Crooks C, Simmons G, Woon ST. Health risks and adverse reactions to functional foods. (2014) Crit Rev Food Sci Nutr, Aug 27. Ameratunga, R., Lindsay, K., Woon, S.-T., Jordan, A., Anderson, N. E. and Koopmans, W. (2014), New diagnostic criteria could distinguish common variable immunodeficiency disorder from anticonvulsant-induced hypogammaglobulinemia. (2014) Clinical and Experimental Neuroimmunology, doi: 10.1111/cen3.12135. Ameratunga, R., Randall, N., Dalziel, S., Anderson, B.J. Samter’s triad in childhood: A warning for those prescribing NSAIDs. (2013) Paediatric Anaesthesia, 23 (8), pp. 757-759. Ameratunga, R., Woon, S.T., Gillis, D., Koopmans, W., Steele, R. New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin. (2013) Clin Exp Immunol, 174 (2), pp. 203-211. Ameratunga, R., Woon, S.T., Gillis, D., Koopmans, W., Steele, R. New diagnostic criteria for CVID. (2014) Expert Rev Clin Immunol, 10 (2), pp. 183-186. Anand-Kumar, V., Kung, M., Painter, L., Broadbent, E. Impact of organ transplantation in heart, lung and liver recipients: Assessment of positive life changes. (2014) Psychology and Health, 29 (6), pp. 687 - 697. Anderson, B.J. My child is unique; the pharmacokinetics are universal. (2012) Pediatr Anesth, 22, pp. 530-538. Anderson, B.J. Pharmacology in the very young: anaesthetic implications. (2012) Eur J Anaesth, 29 (6), pp. 261-270. Anderson, B.J. Pharmacology of Pediatric TIVA. (2013) Rev Colomb Anestesiol, 41, 205-214. Anderson, B.J. Goodbye to needles. (2013) Arch Dis Child, 98, pp. 718-719. Anderson, B.J. Is it farewell to codeine? (2013) Arch Dis Child, 98, pp. 986-988. Anderson, B.J., Dare, T. We need to confirm, not relearn old information. (2014) Pediatr Anesth, 24, pp. 549-552. Anderson, B.J., Holford, N.H.G. Understanding dosing: children are small adults, neonates are immature children. (2013) Arch Dis Child, 98, pp. 732-736. 72 Anderson, B.J., McLay, J., Allegaert, K., Engelhardt, T. Do old pharmacokinetic parameter estimates predict new data? (2012) Br J Anaesth, 109 (6), pp. 1013-1014. Anderson, B.J., van den Anker, J.N. Why is there no morphine concentration-response curve for acute pain? (2014) Pediatr Anesth, 24, pp. 233-238. Anderson, N.H., Sadler, L.C., Stewart, A.W., Fyfe, E.M., McCowan, L.M.E. Independent risk factors for infants who are small for gestational age by customised birthweight centiles in a multi-ethnic New Zealand population (2013) Australian and New Zealand Journal of Obstetrics and Gynaecology, 53 (2), pp. 136-142. Anderson, N.H., Sadler, L.C., Stewart, A.W., Fyfe, E.M., McCowan, L.M.E. Ethnicity and risk of caesarean section in a term, nulliparous New Zealand obstetric cohort. (2013) Australian and New Zealand Journal of Obstetrics and Gynaecology, 53 (3), pp. 258-264. Anderson, N.H., Sadler, L.C., Stewart, A.W., Fyfe, E.M., McCowan, L.M.E. Ethnicity, body mass index and risk of pre-eclampsia in a multiethnic New Zealand population. (2012) Australian and New Zealand Journal of Obstetrics and Gynaecology, 52 (6), pp. 552-558. Anderson, N.H., Sadler, L.C., Stewart, A.W., McCowan, L.M.E. Maternal and pathological pregnancy characteristics in customised birthweight centiles and identification of at-risk smallfor-gestational-age infants: A retrospective cohort study. (2012) BJOG: An International Journal of Obstetrics and Gynaecology, 119 (7), pp. 848-856. Andresen, J.H., Battin, M.R. Late preterm infants and therapeutic hypothermia. (2012) Journal of Paediatrics and Child Health, 48 (1), pp. 78-79. Angeli, T.R., Du, P., Paskaranandavadivel, N., Janssen, P.W., Beyder, A., Lentle, R.G., et al. The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings. (2013) The Journal of Physiology, 591 (Pt 18), pp. 4567-4579. Angeli, T.R., O’Grady, G., Du, P., Paskaranandavadivel, N., Pullan, A.J., Bissett, I.P., et al. Circumferential and functional re-entry of in vivo slow-wave activity in the porcine small intestine. (2013) Neurogastroenterology and Motility: the official journal of the European Gastrointestinal Motility Society, 25 (5), e304-314. 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Young, P., Bailey, M., Bellomo, R., Bernard, S., Dicker, B., Freebairn, R., Henderson, S., Mackle, D., McArthur, C., McGuinness, S., Smith, T., Swain, A., Weatherall, M., Beasley, R. HyperOxic Therapy OR NormOxic Therapy after out-of-hospital cardiac arrest (HOT OR NOT): A randomised controlled feasibility trial. (2014) Resuscitation, 85 (12), pp. 1686 - 1691. Young, P.J., Saxena, M.K., Bellomo, R., Freebairn, R.C., Hammond, N.E., van Haren, F.M., Henderson, S.J., McArthur, C.J., McGuinness, S.P., Mackle, D., Myburgh, J.A., Weatherall, M., Webb, S.A., Beasley, R.W.; for ANZICS Clinical Trials Group. The HEAT trial: a protocol for a multicentre randomised placebo-controlled trial of IV paracetamol in ICU patients with fever and infection. (2012) Critical Care and Resuscitation, 14 (4), pp. 290-296. 107 Young, P.J., Weatherall, M., Saxena, M.K., Bellomo, R., Freebairn, R.C., Hammond, N.E., van Haren, F.M.P., Henderson, S.J., McArthur, C.J., McGuinness, S.P., Mackle, D., Myburgh, J.A., Webb, S.A.R., Beasley, R.W. Statistical analysis plan for the HEAT trial: A multicentre randomised placebo-controlled trial of intravenous paracetamol in intensive care unit patients with fever and infection. (2013) Critical Care and Resuscitation, 15 (4), pp. 279 - 286. Young, R.P., Hopkins, R.J. Chronic Obstructive Pulmonary Disease Detection During Lung Cancer Screening. (2012) JAMA, 307 (7), p. 664. Young, R.P., Hopkins, R.J., Hay, B.A. Joint Effect of Single-Nucleotide Polymorphisms and Smoking Exposure in Chronic Obstructive Pulmonary Disease Risk. (2012) Am J Respir Cell Mol Biol, 185, p. 683. Young, R.P., Hopkins, R.J. Statins and small airways disease in COPD. (2012) Am J Respir Cell Mol Biol. Young, R.P., Hopkins, R.J. A Clinical Practice Guideline Update on the Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease (comment). (2012) Ann Int Med, 156 (1), pp. 68-69. Young, R.P., Hopkins, R.J. CT screening for lung cancer. (2012) Thorax, 67 (7), pp. 650-651 Young, R.P., Hopkins, R.J. Diagnosing COPD and targeted lung cancer screening. (2012) Eur Respir J, 40, pp. 1063-1064. Young, R.P., Hopkins, R.J. Genetic susceptibility testing to lung cancer and outcomes for smokers. (2012) Tobacco Control (online), July 17. Young, R.P., Hopkins, R.J. Increasing smokers’ risk perception improves CT screening participation. (2012) Thorax, 67 (9), pp. 834-835. Young, R.P., Hopkins, R.J. Screening with Low-dose Computed Tomography: Response to the American Association of Thoracic Surgery Guidelines. (2012) The Journal of Thoracic and Cardiovascular Surgery, (http:// dx.org/10.1016/j.jtcvs.2012.08.074). Young, R.P., Hopkins, R.J., Gamble, G.D. Clinical applications of gene-based risk prediction for lung cancer and the central role of chronic obstructive pulmonary disease. (2012) Frontiers in Genetics, 3 (Article 210), pp. 1-7. 108 Young, R.P., Hopkins, R.J. Genetic Variation in Innate Immunity and Inflammation Pathways Associated with Lung Cancer Risk. (2013) Cancer 2013; 119 (9), p. 1761. (online 2012; December 24,doi:10.1002/cncr.27953). Young, R.P., Hopkins, R.J. Genetic risk in Childhood Obesity: Implications for clinical Practice. (2013) JAMA Pediatr, 167 (2), pp. 196-197. Young, R.P., Hopkins, R.J. Estimating Overdiagnosis of Lung Cancer. (2013) Ann Int Med, 158 (8), pp. 635-636. Younossi, Z.M., Stepanova, M., Henry, L., Gane, E., Jacobson, I.M., Lawitz, E., Nelson, D., Gerber, L., Nader, F., Hunt, S. Effects of Sofosbuvir-Based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C. (2014) Clinical Gastroenterology and Hepatology, 12 (8), pp. 1349 - 1359.e13. Younossi, Z.M., Stepanova, M., Nader, F., Jacobson, I.M., Gane, E., Nelson, D., Lawitz, E., Hunt, S.L. Patient-reported outcomes in chronic hepatitis C patients with cirrhosis treated with sofosbuvir-containing regimens. (2014) Hepatology, 59 (6), pp. 2161 - 2169. Young, R.P., Hopkins, R.J. Is 20% of a Loaf Enough? (2013) Cancer 2013, 119 (15), p. 2815. Yu, T.-C., Hamill, J.K., Liley, A., Hill, A.G. Warm, humidified carbon dioxide gas insufflation for laparoscopic appendicectomy in children: A double-blinded randomized controlled trial. (2013) Annals of Surgery, 257 (1), pp. 44-53. Young, R.P., Hopkins, R.J. Statins reduce lung inflammation by promoting the clearance of particulate matter from lung tissue. (2013) Chest, 144 (1), July. DOI:10.1378/chest.13-0496. Zargar, H., Addison, B., Mccall, J., Bartlett, A., Buckley, B., Rice, M. Renal artery embolization prior to nephrectomy for locally advanced renal cell carcinoma. (2014) ANZ Journal of Surgery, 84 (7-8 ), pp. 564 - 567. Young, R.P., Hopkins, R.J. Statin Use in Pneumonia. (2013) Am J Med, 126 (7), e12. Young, R.P., Hopkins, R.J. Interleukin-6 and statin therapy: potential role in the management of COPD. (2013) Respiratory Research, 14, pp. 74-75. Young, R.P., Hopkins, R.J. Targeted CT image screening and its effect on lung cancer detection rate. (2013) Chest, 144 (4), pp. 1419-1420. Young, R.P., Hopkins, R.J. Stage shift in computed tomography screening: possible role of indolent cancers, “Histology Shift”, and Overdiagnosis. (2013) Am J Respir Crit Care Med, 188, pp. 1034-1035. Young, R.P., Hopkins, R.J. Update on the potential role of statins in chronic obstructive pulmonary disease and its co—morbidities. (2013) Expert Rev. Respir. Med, 7 (5), pp. 533-544. Young, S.W., Zhang, M., Freeman, J.T., MutuGrigg, J., Pavlou, P., Moore, G.A. The Mark Coventry award: Higher tissue concentrations of vancomycin with low-dose intraosseous regional versus systemic prophylaxis in TKA: A randomized trial knee. (2014) Clinical Orthopaedics and Related Research, 472 (1), pp. 57 - 65. Zeng, I., Lumley, T., Ruggiero, K., Middleditch, M., Woon, S.T., Stewart, R.A. Two optimization strategies of multi-stage design in clinical proteomic studies. (2013) Statistical Applications in Genetics and Molecular Biology, 12 (2), pp. 263-283. Zeuzem, S., Soriano, S., Asselah, T., Bronowicki, J.P., Lohse, A., Müllhaupt, M., Schuchmann, B., Bourlière, M., Buti, M., Roberts, S., Gane, E., et al. Interferon-free Treatment with Faldaprevir and BI 207127 for Genotype 1 HCV. (2013) New England Journal of Medicine, 369, 630-639. Zhang, S., Wilson, N.C., MacKey, A.H., Stott, N.S. Radiological outcome of reconstructive hip surgery in children with gross motor function classification system IV and v cerebral palsy. (2014) Journal of Pediatric Orthopaedics Part B, 23 (5), pp. 430 - 434. Zhang, Y., Roxburgh, R., Huang, L., Parsons, J., Davies, T.C. The effect of hydrotherapy treatment on gait characteristics of hereditary spastic paraparesis patients. (2014) Gait and Posture, 39 (4), pp. 1074 - 1079. Zwi, L.J., Yiu, T.S.Y., Marshall, M.R., Lam-Po-Tang, M.K. Non-diabetic renal diseases in a multiethnic New Zealand cohort with type 2 diabetes mellitus: Clinical and histopathological features. (2014) Pathology, 46 (5), pp. 424 - 432. Directory Research Office Postal Address Private Bag 92024 Auckland Mail Centre 1142, New Zealand Physical Address 14th Floor, Support Building Auckland City Hospital 2 Park Road, Grafton Auckland 1023, New Zealand Email: [email protected] Website: http://www.adhb.govt.nz/ResearchOffice/ Mary-Anne Woodnorth Helen Wihongi Rong Hu Genevieve Morris Peter Reed Mary Righton Tim Sato Manager Māori Advisor, Research Statistical Advisor and Data Analyst Grants Co-ordinator Statistician – Starship Children’s Health Research Co-ordinator Research Advisor and Co-ordinator Research Review Committee Colin McArthur Margaret Wilsher Richard Frith Chair and Clinical Advisor for Research Chief Medical Officer, Head of Research Ex-officio, Chair of A+ Trust Jane Alsweiler Kim Brackley Elizabeth Broadbent Douglas Campbell Amy Cole Michael Collins Craig Jefferies Catherine Patten Nigel Patton Stephen Ritchie Peter Ruygrok Michael Shepherd Ken Whyte Māori Research Review Committee Heta Tobin Tereki Stewart Edith McNeil John Paterson Dr Sue Crengle kaumatua - Ngati Whatua Chair – Ngati Whatua committee member – Waipareira Whānau Trust committee member – Waitematā and Auckland DHB representative committee member – Māori Public Health Physician 109 Annual Research Report 2014 Auckland District Health Board Graphics April 2013 CC6596 AUCKLAND DISTRICT HEALTH BOARD MedPhoto