Publications by Core Members (2008

Publications by Core Members (2008-Aug, 2012)
Total number: 1681
Clinical-Basic collaborations (circles in the list): 333 (19.8%)
1) Shuh Narumiya
1. Torres D, Paget C, Fontaine J, Mallevaey T, Matsuoka T, Maruyama T, Narumiya S, Capron M,
Gosset P, Faveeuw C, Trottein F (2008) Prostaglandin D2 Inhibits the Production of IFN-g by
Invariant NK T Cells: Consequences in the Control of B16 Melanoma. J Im munol 180:
783-792
2.
○ Koyanagi M, Takahashi J, Arakawa Y, Doi D, Fukuda H, Hayashi H, Narumiya S,
Hashimoto N (2008) Inhibition of the Rho/ROCK pathway reduces apoptosis during
transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res 86: 270-280.
3.
Takeya R, Taniguchi K, Narumiya S, Sumimoto H. (2008) The mammalian formin FHOD1 is
activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre
formation in endothelial cells. EMBO J 27: 618-628
4.
Yuhki KI, Ushikubi F, Naraba H, Ueno A, Kato H, Kojima F, Narumiya S, Sugimoto Y,
Matsushita M, Oh-Ishi S (2008) Prostaglandin I2 Plays a Key Role in Zymosan-Induced Mouse
Pleurisy. J Pharmacol Exp Ther 325: 601-609
5.
Watanabe S, Ando Y, Yasuda S, Hosoya H, Watanabe N, Ishizaki T, Narumiya S (2008)
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during
cytokinesis in NIH 3T3 cells. Mol Biol Cell 19: 2328-2338
6.
○ Wang X, Momota Y, Yanase H, Narumiya S, Maruyama T, Kawatani M (2008) Urothelium
EP1 receptor facilitates the micturition reflex in mice. Biomed Res 29: 105-111.
7.
Matsuoka T, Narumiya S (2008) The roles of prostanoids in infection and sickness behaviors. J
Infect Chemother 14: 270-278
8.
Wei G, Kibler KK, Koehler RC, Maruyama T, Narumiya S, Doré, S (2008) Prostacyclin
receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery
occlusion in mouse. Neuroscience 156: 1111-1117
9.
Tamba S, Yodoi R, Segi-Nishida E, Ichikawa A, Narumiya S, Sugimoto Y (2008) Timely
interaction between prostaglandin and chemokine signaling is a prerequisite for successful
fertilization. Proc Natl Acad Sci U S A 105: 14539-14544.
1
10. Katagiri H, Ito Y, Ito, S, Murata, T, Yukihiko S, Narumiya S, Watanabe M, Majima M (2008)
TNF-a induces thromboxane receptor signaling-dependent microcirculatory dysfunction in
mouse liver. Shock 30: 463-467
11. Higashida C, Suetsugu S, Tsuji T, Monypenny J, Narumiya S, Watanabe N (2008) G-actin
regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers. J Cell
Sci 121: 3403-3412
12. Fujita A, Shishido T, Yuan Y, Inamoto E, Narumiya S, Watanabe N (2009) Imatinib mesylate
(STI571)-induced cell edge translocation of kinase-active and kinase-defective Abelson kinase:
requirements of myristoylation and src homology 3 domain. Mol Pharmacol 75: 75-84
13. Popp L, Häussler A, Olliges A, Nüsing R, Narumiya S, Geisslinger G, Tegeder I (2009)
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane
receptor knockout mice. Eur J Pain, 13(7):691-703
14. ○ Ueta M, Matsuoka T, Narumiya S, Kinoshita S (2009) Prostaglandin E receptor subtype
EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic
conjunctivitis. J Allergy Clin Immunol 123: 466-471
15. Murata T, Lin MI, Aritake K, Matsumoto S, Narumiya S, Ozaki H, Urade Y, Hori M, Sessa
WC (2008) Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability
and angiogenesis in vivo. Proc Natl Acad Sci U S A 105: 20009-20014
16. Miki T, Okawa K, Sekimoto T, Yoneda Y, Watanabe S, Ishizaki T, Narumiya S (2009) mDia2
shuttles between the nucleus and the cytoplasm through the importin-a/b- and CRM1-mediated
nuclear transport mechanism. . Biol Chem 284: 5753-5762
17. Nemenoff R, Meyer AM, Hudish TM, Mozer AB, Snee A, Narumiya S, Stearman RS, Winn
RA, Weiser-Evans M, Geraci MW, Keith RL (2008) Prostacyclin prevents murine lung cancer
independent of the membrane receptor by activation of peroxisomal proliferator-activated
receptor-g. Cancer Prev Res 1: 349-356.
18. Furuyashiki T, Narumiya S (2009) Roles of prostaglandin E receptors in stress responses. Curr
Opin Pharmacol 9: 31-38
19. ○ Narumiya S, Tanji M, Ishizaki T (2009) Rho signaling, ROCK and mDia1, in
transformation, metastasis and invasion. Cancer Metastasis Rev 28: 65-76
2
20. Saleem S, Kim YT, Maruyama T, Narumiya S, Doré S (2009) Reduced acute brain injury in
PGE2 EP3 receptor-deficient mice after cerebral ischemia. J Neuroimmunol 208: 87-93.
21. Monypenny J, Zicha D, Higashida C, Oceguera-Yanez F, Narumiya S, Watanabe N (2009)
Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary
fibroblast migration during PDGF-dependent chemotaxis. Mol Cell Biol, 29: 2730-2747
22. Tsuji T, Miyoshi T, Higashida C, Narumiya S, Watanabe N (2009) An order of magnitude
faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodia.
PLoS ONE, 4: e4921
23. Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Kitasato H, Hayashi I, Kato T,
Sugimoto Y, Narumiya S, Watanabe M, Majima M (2009) Bone Marrow-derived
EP3-expressing Stromal Cells Enhance Tumor-associated Angiogenesis and Tumor Growth.
Biochem Biophys Res Commun 382: 720-725
24. Yodoi R, Tamba S, Morimoto K, Segi-Nishida E, Nishihara M, Ichikawa A, Narumiya S,
Sugimoto Y (2009) RhoA/ROCK Signaling in the Cumulus Mediates Extracellular Matrix
Assembly. Endocrinology 150: 3345-3352
25. Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K, Sugimoto Y, Narumiya S (2009)
Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell
differentiation and TH17 cell expansion. Nat Med 15: 633-640
26. ○ Oga T, Matsuoka T, Yao C, Nonomura K, Kitaoka S, Sakata D, Kita Y, Tanizawa K,
Taguchi Y, Chin K, Mishima M, Shimizu T, Narumiya S (2009) Prostaglandin F2α-FP
signaling facilitates bleomycin-induced pulmonary fibrosis independently of TGF-b. Nat Med
15: 1426-1430
27. Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujiwara F, Trichereau J,
Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi
N, von Haeseler A, Bader M, Kilic SS, Ueta Y, Pifl C, Narumiya S, Penninger JM (2009)
Central control of fever and female body temperature by the osteoclast differentiation factors
RANKL/RANK. Natur e 462: 505-509
28. Tanaka Y, Furuyashiki T, Momiyama T, Namba H, Mizoguchi A, Mitsumori T, Kayahara T,
Shichi H, Kimura K, Matsuoka T, Nawa H, Narumiya S (2009) Prostaglandin E receptor EP1
enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars
compacta and regulates dopamine level in the dorsal striatum. Eur J Neurosci 30: 2338-2346
3
29. ○ Honda T, Matsuoka T, Ueta M, Kabashima K, Miyachi Y, Narumiya S (2009)
ProstaglandinE2-EP3 signaling suppresses skin inflammation in mouse contact hypersensitivity.
J Allergy Clin Immunol 124: 809-818.
30. Narumiya S (2009) Prostanoids and inflammation: a new concept arising from receptor
Knockout mice. J Mol Med 87: 1015-1022
31. ○ Nakase H, Fujiyama Y, Oshitani N, Oga T, Nonomura K, Matsuoka T, Esaki Y, Murayama
T, Teramukai S, Chiba T, Narumiya S (2009) Effect of EP4 agonist (ONO-4819CD) for
patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: A randomized
phase II, placebo-controlled trial. Inflamm Bowel Dis 16: 732-734
32. Amano H, Ito Y, Suzuki T, Kato S, Matsui Y, Ogawa F, Murata T, Sugimoto Y, Senior R,
Kitasato H, Hayashi I, Satoh Y, Narumiya S, Majima M (2009) Roles of a prostaglandin E-tape
receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth
factor during enhancement of tumor metastasis. Cancer Sci 100: 2318-2324.
33. Duffy P, Schmandke A, Schmandke A, Sigworth J, Narumiya S, Cafferty W, Strittmatter S
(2009) Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult
mouse spinal cord. J Neurosci 29: 15266-15276
34. Narumiya S, Watanabe N (2009) Migration without a clutch. Nat Cell Biol 11: 1394-1396
35. Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H,
Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M (2010) COX-2 and
prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment
via CXCL12-CXCR4z chemokine systems. Am J Pathol 176: 1469-1483
36. Sakata D, Yao C, Narumiya S (2010) Prostaglandin E2, an immunoactivator. J Pharmacol Sci.
112: 1-5.
37. Kubo H, Hosono K, Suzuki T, Ogawa Y, Kato H, Kamata H, Ito Y, Amano H, Kato T,
Sakagami H, Hayashi I, Sugimoto Y, Narumiya S, Watanabe M, Majima M (2010) Host
prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. Biomed
Pharmacother 64: 101-106
38. Ueno T, Suzuki T, Oikawa A, Hosono K, Kosaka Y, Amano H, Kitasato H, Toda M, Hayashi I,
Kato T, Ito Y, Sugimoto Y, Narumiya S, Okamoto H, Majima M (2010) Recruited bone
marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during
chronic inflammation. Biomed Pharmacother 64: 93-100
4
39. Kawabe J, Yuhki K, Okada M, Kanno T, Yamauchi A, Tashiro N, Sasaki T, Okumura S,
Nakagawa N, Aburakawa Y, Takehara N, Fujino T, Hasebe N, Narumiya S, Ushikubi F (2010)
Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular
remodeling. Arterioscler Thromb Vasc Biol 30: 464-470
40. ○ Terada N, Shimizu Y, Kamba T, Inoue T, Maeno A, Kobayashi T, Nakamura E, Kamoto T,
Kanaji T, Maruyama T, Mikami Y, Toda Y, Matsuoka T, Okuno Y, Tsujimoto G, Narumiya S,
Ogawa O (2010) Identification of EP4 as a potential target for the treatment of
castration-resistant prostate cancer using a novel xenograft model. Cancer Res 70: 1606-15
41. Tamba S, Yodoi R, Morimoto K, Inazumi T, Sukeno M, Segi-Nishida E, Okuno Y, Tsujimoto
G, Narumiya S, Sugimoto Y (2010) Expression profiling of cumulus cells reveals functional
changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling.
Biochimie 92: 665-675
42. ○ Nakajima S, Honda T, Sakata D, Egawa G, Tanizaki H, Otsuka A, Moniaga CS, Watanabe
T, Miyachi Y, Narumiya S, Kabashima K (2010) Prostaglandin I2-IP signaling promotes Th1
differentiation in a mouse model of contact hypersensitivity. J Immunol 15: 5595-5603.
43. Chan EC, Dusting GJ, Guo N, Peshavariya HM, Taylor CJ, Dilley R, Narumiya S, Jiang F
(2010) Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation. J Mol
Cell Cardiol A49: 176-185.
44. ○ Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T, Fukuda K, Narumiya S
(2010) Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune
encephalomyelitis. Proc Natl Acad Sci USA 107: 12233-12238
45. Ahmad M, Saleem S, Shah Z, Maruyama T, Narumiya S, Doré S (2010) The PGE2 EP2
receptor and its selective activation are beneficial against ischemic stroke. Exp Transl Stroke
Med 2: 12.
46. Saleem S, Shah ZA, Maruyama T, Narumiya S, Doré S (2010) Neuroprotective properties of
prostaglandin I2 IP receptor in focal cerebral ischemia. Neuroscience 170(1): 317-323
47. Ahmad AS, Ahmad M, Maruyama T, Narumiya S, Doré S (2010) Prostaglandin D2 DP1
receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. Age
(Dordr), 32: 271-282.
5
48. Watanabe S, Okawa K, Miki T, Sakamoto S, Morinaga T, Segawa K, Arakawa T, Kinoshita M,
Ishizaki T, Narumiya S (2010) Rho and Anillin-dependent Control of mDia2 Localization and
Function in Cytokinesis. Mol Biol Cell 21: 3193-3204.
49. Kuriyama S, Kashiwagi H, Yuhkim KI, Kojimam F, Yamadam T, Fujino T, Hara A.,
Takayama K, Maruyama T, Yoshida A, Narumiya S, Ushikubi F (2010) Selective activation of
the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation.
Thromb Haemost. 104(4): 796-803
50. Sakata D, Yao C, Narumiya S (2010) Emerging roles of prostanoids in T cell-mediated
immunity. IUBMB Life 62: 591-596.
51. ○ Tanji M, Ishizaki T, Ebrahimi S, Tsuboguchi Y, Sukezane T, Akagi T, Frame MC,
Hashimoto N, Miyamoto S, Narumiya S (2010) mDia1 Targets v-Src to Cell Periphery and
Facilitates Cell Transformation, Tumorigenesis and Invasion. Mol Cell Biol 30: 4604-4615.
52. Ohgushi M, Matsumura M, Eirakum M, Murakami K, Aramaki T, Nishiyama A, Muguruma K,
Nakano T, Sugam H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y (2010)
Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human
Pluripotent Stem Cells. Cell Stem Cell 7: 225-239.
53. Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T, Hayashi I,
Sugimoto Y, Narumiya S, Saigenji K, Majima M. (2010) Roles of prostaglandin E2-EP1
receptor signaling in regulation of gastric motor activity and emptying. Am J Physiol
Gastrointest Liver Physiol. 299: G1078-1086.
54. Furuyashiki T, Narumiya S (2010) Stress responses: the contribution of prostaglandin E2 and
its receptors. Nat Rev Endocrinol 7: 163-175.
55. Yuhki K, Kojima F, Kashiwagi H, Kawabe J, Fujino T, Narumiya S, Ushikubi F (2011) Roles
of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout
mouse studies. Pharmacol Ther 129: 195-205.
56. Eguchi M, Kariya S, Okano M, Higaki T, Makihara S, Fujiwara T, Nagata K, Hirai H,
Narumiya S, Nakamura M, Nishizaki K. (2011) Lipopolysaccharide induces proinflammatory
cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor
(DP)-dependent pathway. Clin Exp Immunol 163: 260-269.
6
57. Mizuno H, Higashida C, Yuan Y, Ishizaki T, Narumiya S, Watanabe N (2011) Rotational
movement of the formin mDia1 along the double helical strand of an actin filament. Science
331: 80-83
58. ○ Tanizaki H, Egawa G, Inaba K, Honda T, Nakajima S, Moniaga CS, Otsuka A, Ishizaki T,
Tomura M, Watanabe T, Miyachi Y, Narumiya S, Okada T, Kabashima K. (2010) Rho-mDia1
pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells. Blood,
116: 5875-5884.
59. ○ Aoki T, Nishimura M, Matsuoka T, Yamamoto K, Furuyahsiki T, Kataoka H, Kitaoka S,
Ishibashi R, Ishibazawa A, Miyamoto S, Motishita R, Ando J, Hashimoto N, Nozaki K,
Narumiya S (2011) PGE2-EP2 signaling in endothelium is activated to hemodynamic stress
and induces cerebral aneurysm through an amplifying loop via NF-kB. Br J Phar macol 163:
1237-1249.
60. Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M
(2011) Roles of Prostaglandin E2-EP3/EP4 Receptor Signaling in the Enhancement of
Lymphangiogenesis During Fibroblast Growth Factor-2-Induced Granulation Formation.
Arterioscler Thromb Vasc Biol 31:1049-1058.
61. Narumiya S, Furuyashiki T (2011) Fever, inflammation, pain and beyond: prostanoid receptor
research during these 25 years. FASEB J. 25: 813-818
62. Johansson T, Narumiya S, Zeilhofer HU (2011) Contribution of peripheral versus central EP1
prostaglandin receptors to inflammatory pain. Neurosci Lett 495: 98-101.
63. ○ Soontrapa K, Honda T, Sakata D, Yao C, Hirata T, Hori S, Matsuoka T, Kita Y, Shimizu T,
Kabashima K, Narumiya S (2011) Prostaglandin E2-EP4 signaling mediates UV
irradiation-induced systemic immunosuppression. Proc Natl Acad Sci USA 108: 6668-6673
64. ○ Fujita T, Matsuoka T, Honda T, Kabashima K, Hirata T, Narumiya S (2011) A GPR40
agonist GW9508 suppresses CCL5, CCL17 and CXCL10 induction in keratinocytes and
attenuates cutaneous immune inflammation. J Invest Dermatol 131: 1660-1667.
65.
Zhen G, Kim YT, Li RC, Yocum J, Kapoor N, Langer J, Dobrowolski P, Maruyama T,
Narumiya S, Doré S. (2011) PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of
cerebral ischemia and Alzheimer's disease. Neurobiol Aging 33(9): 2215-2219
7
66.
Thumkeo D, Shinohara R, Watanabe K, Takebayashi H, Toyoda Y, Tohyama K, Ishizaki T,
Furuyashiki T, Narumiya S. (2011) Deficiency of mDia, an Actin Nucleator, Disrupts Integrity
of Neuroepithelium and Causes Periventricular Dysplasia. PLoS One 6(9):e25465
67.
Kamijo H, Matsumura Y, Thumkeo D, Koike S, Masu M, Shimizu Y, Ishizaki T, Narumiya
S. (2011) Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and
ROCK-II. Genes Cells 16(10):1012-1021.
68.
Hirata T, Narumiya S. (2011) Prostanoid receptors. Chem Rev 111(10): 6209-6230.
69.
Ikeda-Matsuo Y, Tanji H, Narumiya S, Sasaki Y. (2011) Inhibition of prostaglandin E2 EP3
receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms. J
Neuroimmunol 238(1-2):34-43.
70.
Woodward DF, Jones RL, Narumiya S (2011) International union of basic and clinical
pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress.
Pharmacol Rev 63(3): 471-538.
71.
Mitsumori T, Furuyashiki T, Momiyama T, Nishi A, Shuto T, Hayakawa T, Ushikubi F,
Kitaoka S, Aoki T, Inoue H, Matsuoka T, Narumiya S. (2011) Thromboxane receptor
activation enhances striatal dopamine release, leading to suppression of GABAergic
transmission and enhanced sugar intake. Eur J Neurosci 34(4):594-604.
72.
Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H,
Nakamura M, Satoh T (2011) Dual functions of prostaglandin D2 in murine contact
hypersensitivity via DP and CRTH2. Am J Pathol 179(1):302-14.
73.
Suzuki C, Miyamoto C, Furuyashiki T, Narumiya S, Ohinata K. (2011) Central PGE2
exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin
5-HT1A, dopamine D1 and GABAA receptors. FEBS Lett 585(14):2357-2362.
74.
Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S,
Suzuki T, Mizushima T. (2012) Improvement of cognitive function in Alzheimer's disease
model mice by genetic and pharmacological inhibition of the EP4 receptor. J N eurochem
120(5): 795-805.
75.
Tajima T, Murata T, Aritake K, Urade Y, Michishita M, Matsuoka T, Narumiya S, Ozaki H,
Hori M. (2012) EP2 and EP4 receptors on muscularis resident macrophages mediate
LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Am J
Physiol Gastrointest Liver Physiol 302(5):G524-34.
8
76.
○ Hamaguchi K, Yamamoto N, Nakagawa T, Furuyashiki T, Narumiya S, Ito J. (2012)
Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice.
Neuropharmacology 62(4):1841-1847
77.
Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H,
Narumiya S, Koizumi W, Majima M. (2012) Thromboxane A2 receptor signaling promotes
liver tissue repair after toxic injury through the enhancement of macrophage recruitment.
Toxicol Appl Pharmacol 259(1):104-14
78.
Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H,
Kiyonari H, Ishizaki T, Furuyashiki T, Narumiya S. A role for mDia, a Rho-regulated actin
nucleator, in tangential migration of interneuron precursors. Nat Neurosci 15(3): 373-380
79.
Sakamoto S, Ishizaki T, Okawa K, Watanabe S, Arakawa T, Watanabe N, Narumiya S.
(2012) Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane
localization. J Cell Sci 125(1): 108-120
80.
Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S,
Nakamura M, Kitasato H, Narumiya S, Majima M. (2012) Thromboxane A2 receptor signaling
facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with
platelets and endothelial cells. Cancer Sci 103(4): 700-707
81.
○ Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T,
Akira S, Narumiya S, Tashiro K, Kinoshita S (2012) Epistatic interaction between Toll-like
receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes. J Allergy Clin Immunol
129(5): 1413-1416
82.
Tanaka K, Furuyashiki T, Kitaoka S, Senzai Y, Imoto Y, Segi-Nishida E, Deguchi Y, Breyer
RM, Breyer MD, Narumiya S (2012) Prostaglandin E2-mediated attenuation of mesocortical
dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. J
Neurosci 32(12): 4319-4329.
83.
Aoki T, Narumiya S (2012) Prostaglandins and chronic inflammation. Trends Pharmacol Sci
33(6): 304-311
84.
Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F,
Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F (2012) The intrinsic
prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of
tubulointerstitial fibrosis in mice. Kidney Int 82(2): 158-171
9
85.
Vennemann A, Gerstner A, Kern N, Ferreiros Bouzas N, Narumiya S, Maruyama T, Nüsing
RM (2012) PTGS-2-PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic
Toxicity of Streptozotocin in Mice. Diabetes 61(7): 1879-1887
86.
Frölich S, Olliges A, Kern N, Schreiber Y, Narumiya S, Nüsing RM (2012) Temporal
expression of the PGE2 synthetic system in the kidney is associated with the time frame of
renal developmental vulnerability to cyclooxygenase-2 inhibition. Am J Physiol Renal Physiol
303(2): F209-219.
87.
○ Imai K, Ueta M, Mori K, Ueno M, Ikeda Y, Oga T, Yokoi N, Shinomiya K, Narumiya S,
Kinoshita S (2012) Expression of prostaglandin F receptor in scleral and subconjunctival tissue.
Br J Ophthalmol 96(8):1148-1149.
88.
Kim YT, Moon SK, Maruyama T, Narumiya S, Doré S (2012) Prostaglandin FP receptor
inhibitor reduces ischemic brain damage and neurotoxicity. Neurobiol Dis 48(1):58-65.
89.
Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K,
Furuyashiki T, Narumiya S, Urade Y, Ohinata K. (2012) Orally administered rubiscolin-6, a δ
opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type
prostaglandin D synthase in mice. Mol Nutr Food Res 56(8):1315-1323
90.
Sakamoto S, Narumiya S, Ishizaki T (2012) A new role of multi scaffold protein Liprin-α:
Liprin-α suppresses Rho-mDia mediated stress fiber formation. Bioarchitecture 2(2):43-49.
91.
Guo Y, Tukaye DN, Wu WJ, Zhu X, Book M, Tan W, Jones SP, Rokosh G, Narumiya S, Li
Q, Bolli R. (2012) The COX-2/PGI2 Receptor Axis Plays an Obligatory Role in Mediating the
Cardioprotection Conferred by the Late Phase of Ischemic Preconditioning. PLoS One
7(7):e4117
92.
Hirata T, Nomachi A, Tohya K, Miyasaka M, Tsukita S, Watanabe T, Narumiya S. (2012)
Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis. Int
Immunol 2012 Aug 8. [Epub ahead of print]
2) Nagahiro Minato
1.
Wang, S-F, Aoki, M., Shinozuka, Y., Nakashima, Y., Tanaka, H., Taniwaki, F., Hattori, M., and
Minato, N. (2008) Development of Notch-dependent T cell leukemia by deregulated Rap1
signaling. Blood 111:3011-3016.
10
2.
Lin, D. Y., Tanaka, Y., Iwasaki, M., Gitttis, A. G., Su, H-P., Mikami, B., Okazaki, T., Honjo, T.,
Minato, N., and Garboczi, D, N. (2008) Structure of the human programmed death (PD)-1
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4) Shimon Sakaguchi
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M (2011) Histological changes in chronic autoimmune SKG-arthritis evaluated by quantitative
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17
22. Peterson L K, Shaw L A, Joetham A, Sakaguchi S, Gelfand E W, Dragone L L (2011) SLAP
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18
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35. Teng M W, Swann J B, von Scheidt B, Sharkey J, Zerafa N, McLaughlin N, Yamaguchi T,
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37. Hashimoto M, Hirota K, Yoshitomi H, Maeda S, Teradaira S, Akizuki S, Prieto-Martin P,
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19
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interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.
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20
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56. Miyara M, Sakaguchi S (2008) Regulatory T Cells and the Control of Auto -Immunity: From
day 3 Thymectomy to FoxP3+ Regulatory T Cells. In Regulatory T cells and Clinical
Application, Ed. S. Jiang, Springer, p3-16
57. Sakihama T, Sato T, Iwanari H, Kitamura T, Sakaguchi S, Kodama T, Hamakubo T. (2008) A
simple detection method for low-affinity membrane protein interactions by baculoviral display.
PLoS ONE. 3(12):e4024.
58. ○ Satoda N, Shoji T, Wu Y, Fujinaga T, Chen F, Aoyama A, Zhang J T, Takahashi A,
Okamoto T, Matsumoto I, Sakai H, Li Y, Zhao X, Manabe T, Kobayashi E, Sakaguchi S, Wada
H, Ohe H, Uemoto S, Tottori J, Bando T, Date H, Koshiba T (2008) Value of FOXP3
Expression in Peripheral Blood as Rejection Marker After Miniature Swine Lung
Transplantation. J. Heart Lung Transplant. 27:1293-1301
59. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T,
Sakaguchi S (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science.
322:271-275
60. ○ Li Y, Zhao, X, Cheng D, Haga H, Tsuruyama T, Wood K, Tanaka, K., Uemoto S, Koshiba
(2008) T The presence of FOXP3 expressing T cells within grafts of tolerance human liver
transplant recipients. Transplantation. 86:1837-1843
61. Sharma S, Dominguez A L, Manrique S Z, Cavallo F, Sakaguchi S, Lustgarten J (2008)
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Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid
molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant
mice. Cancer Res. 68:7530-7540
62. Wakasa-Morimoto C, Toyosaki-Maeda T, Matsutani T, Yoshida R, Nakamura-Kikuoka, S.,
Maeda-Tanimura, M., Yoshitomi, H., Hirota, K., Hashimoto H, Masaki H, Fujii F, Sakata T,
Tsuruta Y, Suzuki R, Sakaguchi N, Sakaguchi S (2008) Arthritis and pneumonitis produced
by the same T-cell clones from mice with spontaneous autoimmune arthritis. Int. Immunol.
20:1331-1342
Sakaguchi S (2008) Foxp3+ natural regulatory T cells
preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.
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tolerance. Cell. 133: 775-787
65. Miyara M, Sakaguchi S (2008) Immune Dysregulation, Polyendocrinopathy, Enteropathy,
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66. Fehervari Z, Sakaguchi S (2008) T lymphocytes: Regulatory. In Nature Encyclopedia of Life
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5) Tsuneyo Mimori
2012
1) Fujita Y, Yanagida H, Mimori T, Jin ZX, Sakai T, Kawanami T, Sawaki T, Masaki Y,
Fukushima T, Okazaki T, Umehara H (2012) Prevention of fasting-mediated bone marrow
atrophy by leptin administration. Cell Immunol. 273(1):52-8.
2) ○ Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T,
Atsumi T, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K,
Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C,
Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y,
Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N,
Yamada R, Nakamura Y, Yamamoto K (2012) A Genome-Wide Association Study Identified
22
AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese. PLoS Genet.
8(1):e1002455.
3) Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T,
Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, Suzuki R, Takegami T, Tomosugi N,
Kurose N, Ishigaki Y, Azumi A, Kojima M, Nakamura S, Inoue D; The Research Program for
Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team (2012)
A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod
Rheumatol 22(1):1-14.
4) Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T,
Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito
T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H,
Inui K, Ohara H (2012) Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD),
2011. Mod Rheumatol. 22(1):21-30.
5) ○ Meziani R, Yamada R, Takahashi M, Ohigashi K, Morinobu A, Terao C, Hiratani H,
Ohmura K, Yamaguchi M, Nomura T, Vasilescu A, Kokubo M, Renault V, Hirosawa K,
Ratanajaraya C, Heath S, Mimori T, Sakaguchi S, Lathrop M, Melchers I, Kumagai S, Matsuda
F (2012) A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate
common risk factor in Japanese and European populations. Mod Rheumatol. 22(1):52-8.
6) Murakami K, Tanaka M, Usui T, Kawabata D, Shiomi A, Iguchi-Hashimoto M, Shimizu M,
Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Mimori T (2012) Follistatin-related protein/
follistatin-like 1 evokes an innate immune response via CD14 and toll- like receptor 4. FEBS
Lett. 586(4):319-24.
7) Bonroy C, Van Praet J, Smith V, Van Steendam K, Mimori T, Deschepper E, Deforce D,
Devreese K, De Keyser F (2012) Optimization and diagnostic performance of a single
multiparameter lineblot in the serological workup of systemic sclerosis. J Immunol Methods.
379(1-2):53-60.
8) Mimori T, Nakashima R, Hosono Y (2012) Interstitial lung disease in myositis: Clinical subsets,
biomarkers, and treatment. Curr Rheumatol Rep 14(3):264-74.
9) ○ Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA,
Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y,
Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K,
Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y,
Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA,
23
Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N,
Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K
(2012) Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the
Japanese population. Nat Genet. 44(5):511-6.
10) Kiyama K, Kawabata D, Hosono Y, Kitagori K, Yukawa N, Yoshifuji H, Ohmura K, Fujii T,
Mimori T (2012) Serum BAFF and APRIL levels in patients with IgG4-related disease and
their clinical significance. Arthritis Res Ther. 14(2):R86.
11) ○ Terao C, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, Saji H, Taniguchi A,
Momohara S, Yamanaka H, Matsuda F, Mimori T (2012) Quantitative effect of HLA-DRB1
alleles to ACPA levels in Japanese rheumatoid arthritis: no strong genetic impact of shared
epitope to ACPA levels after stratification of HLA-DRB1*09:01. Ann Rheum Dis.
71(6):1095-7.
12) Ohmura K, Terao C, Mimori T (2012) Recent advances on the genetics of rheumatoid arthritis:
Current topics and the future.
Inflammation and Regeneration 32(3):90-98.
13) Terao C, Ohmura K, Yamamoto K, Yukawa N, Kawabata D, Nojima T, Fujii T, Mimori T
(2012) Serum IgG levels demonstrate seasonal change in connective tissue diseases: a
large-scale, 4-year analysis in Japanese. Mod Rheumatol. 22(3):426-30.
14) ○ Terao C, Ohmura K, Ikari K, Kochi Y, Maruya E, Katayama M, Yurugi K, Shimada K,
Murasawa A, Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara
S, Yamanaka H, Yamada R, Saji H, Matsuda F, Mimori T (2012) ACPA-negative RA consists
of two genetically distinct subsets based on RF positivity in Japanese. PLoS One .
7(7):e40067.
15) Imura Y, Shirai Y, Nojima T, Nakashima R, Yamagata H, Miyachi K, Yoshifuji H, Kawabata D,
Ohmura K, Usui T, Fujii T, Mimori T (2012) NEFA/nucleobindin-2 is a target autoantigen of
the anti-Wa antibody and is associated with transfer RNA. Mod Rheumatol. 2012 Jan 24.
[Epub ahead of print]
16) Shoji T, Bando T, Fujinaga T, Chen F, Sasano H, Yukawa N, Mimori T, Date H (2012)
Living-donor lobar lung transplantation for rapidly progressive interstitial pneumonia
associated with clinically amyopathic dermatomyositis: report of a case. Gen Thorac
Cardiovasc Surg. 2012 May 23. [Epub ahead of print]
17) Sakai R, Tanaka M, Nanki T, Watanabe K, Yamazaki H, Koike R, Nagasawa H, Amano K,
Saito K, Tanaka Y, Ito S, Sumida T, Ihata A, Ishigatsubo Y, Atsumi T, Koike T, Nakajima A,
24
Tamura N, Fujii T, Dobashi H, Tohma S, Sugihara T, Ueki Y, Hashiramoto A, Kawakami A,
Hagino N, Miyasaka N, Harigai M, Komano Y, Hirata S, Hayashi T, Takeno M, Yasuda S,
Takanasaki Y, Mimori T, Shiozawa S, Ida H, Eguchi K, Yamamoto K, Ezawa K, Ochi S,
Nagasaka K, Kameda H, Kaneko Y, Takeuchi T, Migita K, Miura Y, Sawada T, Nakajima A,
Yamanaka H, Nonomura, Y (2012) Drug retention rates and relevant risk factors for drug
discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine
therapy with different target molecules. Ann Rheum Dis. 13 April 2012. [Epub ahead of
print]
18) Ishiguro N, Yamamoto K, Katayama K, Kondo M, Sumida T, Mimori T, Soen S, Nagai K,
Yamaguchi T, Hara M (2012) Iguratimod-Clinical Study Group. Concomitant iguratimod
therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a
randomized, double-blind, placebo-controlled trial. Mod Rheumatol. 2012 Jul 26. [Epub
ahead of print]
19) ○ Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A, Ikari K, Takahashi A, Kubo M,
Taniguchi A, Matsuda F, Ohmura K, Momohara S, Mimori T, Yamanaka H, Kamatani N,
Yamada R, Nakamura Y, Yamamoto K (2012) Functional Variants in NFKBIE and RTKN2
Involving Activation of the NF-kB Pathway Predispose Rheumatoid Arthritis in Japanese.
PLoS Genetics , in press.
2011
1) Ishikawa Y, Yukawa N, Ohmura K, Hosono Y, Imura Y, Kawabata D, Nojima T, Fujii T, Usui T,
Mimori T (2011) A case of anti-synthetase syndrome in a rheumatoid arthritis patient with
anti-PL-12 antibody following treatment with etanercept. Clin Rheumatol 30(3):429-32.
2) Zaima C, Kanai M, Ishikawa S, Kawaguchi Y, Masui S, Mori Y, Nishimura T, Matsumoto S,
Yanagihara K, Chiba T, Mimori T (2011) A case of progressive digital ischemia after early
withdrawal of gemcitabine and S-1 in a patient with systemic sclerosis. Jpn J Clin Oncol
41(6):803-6.
3) ○ Terao C, Yamada R, Ohmura K, Takahashi M, Kawaguchi T, Kochi Y, Human Disease
Genomics Working Group, RA Clinical and Genetic Study Consortium, Okada Y, Nakamura Y,
Yamamoto K, Melchers I, Lathrop M, Mimori T, Matsuda F (2011) The human AIRE gene at
chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in
Japanese population. Hum Mol Genet. 20(13):2680-5.
4) ○ Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, Toda Y, Yamamoto
N; Human Disease Genomics Working Group; Rheumatoid Arthritis (RA) Clinical and Genetic
Study Consortium, Shinkura R, Shimizu M, Gut I, Heath S, Melchers I, Manabe T, Lathrop M,
25
Mimori T, Yamada R, Matsuda F (2011) Myelin basic protein as a novel genetic risk factor in
rheumatoid arthritis - a genome-wide study combined with immunological analyses. PLoS
One 6(6):e20457.
5) Van Praet J, Van Steendam K, Smith V, De Bruyne G, Mimori T, Bonroy C, Elewaut D, Deforce
D, De Keyser F (2011) Specific antinuclear antibodies in systemic sclerosis patients with and
without skin involvement: an extended methodological approach. Rheumatology (Oxford)
50(7):1302-9.
6) Watanabe K, Handa T, Tanizawa K, Hosono Y, Taguchi Y, Noma S, Kobashi Y, Kubo T, Aihara
K, Chin K, Nagai S, Mimori T, Mishima M (2011) Detection of antisynthetase syndrome in
patients with idiopathic interstitial pneumonias. Respir Med. 105(8):1238-47.
7) Takeda N, Nojima T, Terao C, Yukawa N, Kawabata D, Ohmura K, Usui T, Fujii T, Ito Y,
Inuma Y, Mimori T (2011) Interferon-γrelease assay for diagnosing Mycobacterium
tuberculosis diseases in patients with systemic lupus erythematosus.
2011.
Lupus
20(8):792-800,
8) Tanizawa K, Handa T, Nakashima R, Kubo T, Hosono Y, Watanabe K, Aihara K, Oga T, Chin K,
Nagai S, Mimori T, Mishima M (2011) HRCT features of interstitial lung disease in
dermatomyositis with anti-CADM-140 antibody. Resp Med 105(9):1380-7.
9) Arima K, Kinoshita A, Mishima H, Kanazawa N, Kaneko T, Mizushima T, Ichinose K,
Nakamura H, Tsujino A, Kawakami A, Matsunaka M, Kasagi S, Kawano S, Kumagai S,
Ohmura K, Mimori T, Hirano M, Ueno S, Tanaka K, Tanaka M, Toyoshima I, Sugino H,
Yamakawa A, Tanaka K, Niikawa N, Furukawa F, Murata S, Eguchi K, Ida H, Yoshiura KI
(2011) Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation
causes the autoinflammatory disorder, Nakajo-Nishimura syndrome. Proc Natl Acad Sci
USA. 108(36):14914-9.
10) Kimura E, Kobayashi S, Kanatani Y, Ishihara K, Mimori T, Takahashi R, Chiba T, Yoshihara H
(2011) Developing an electronic health record for intractable diseases in Japan. Stud Health
Technol Inform. 169:255-9, 2011.
11) ○ Terao C, Ohmura K, Kochi Y, Ikari K, Maruya E, Katayama M, Shimada K, Murasawa A,
Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka
H, Yamada R, Saji H, Matsuda F, Mimori T (2011) A large-scale association study identified
multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese
subjects. Ann Rheum Dis. 70(12):2134-9.
26
12) Iguchi-Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, Murakami K,
Shiomi A, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T (2011)
Overexpression of minimal domain of calpastatin suppresses IL-6 production and Th17
development via reduced NF-kB and increased STAT5 signals. PLoS ONE 6(10):e27020.
13) Yukawa N, Fujii T, Kondo-Ishikawa S, Yoshifuji H, Kawabata D, Nojima T, Ohmura K, Usui
T, Mimori T (2011) Correlation of antinuclear antibody and anti-double-stranded DNA
antibody with clinical response to infliximab in patients with rheumatoid arthritis: a
retrospective clinical study. Arthritis Res Ther 13(6):R213.
2010
1) Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura
K, Usui T, Fujii T, Okawa K, Mimori T (2010) The RIG-I-like receptor IFIH1/MDA5 is a
dermatomyositis-specific
autoantigen
recognized
by
anti-CADM-140
antibody.
Rheumatology (Oxford) 49(3):433-40.
2) Higashi T, Nakayama T, Fukuhara S, Yamanaka H, Mimori T, Ryu J, Yonenobu K, Murata N,
Matsuno H, Ishikawa H, Ochi T (2010) Opinions of Japanese rheumatology physicians
regarding clinical practice guidelines. Int J Qual Health Care 22(2):78-85.
3) Ishikawa Y, Yukawa N, Ohmura K, Hosono Y, Imura Y, Kawabata D, Nojima T, Fujii T, Usui T,
Mimori T (2010) Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with
rheumatoid arthritis: a case report and review of the literature. Clin Rheumatol 29(5):563-6.
4) Ichikawa Y, Saito T, Yamanaka H, Akizuki M, Kondo H, Kobayashi S, Oshima H, Kawai S,
Hama N, Yamada H, Mimori T, Amano K, Tanaka Y, Matsuoka Y, Yamamoto S, Matsubara T,
Murata N, Asai T, Suzuki Y (2010) Clinical activity after 12 weeks of treatment with
nonbiologics in early rheumatoid arthritis may predict articular destruction 2 years later. J
Rheumatol 37(4):723-9.
5) Shoji T, Bando T, Fujinaga T, Okubo K, Yukawa N, Mimori T, Date H (2010) Living-donor
lobar lung transplantation for interstitial pneumonia associated with dermatomyositis.
Transpl Int 23(5):e10-1.
6) ○ Yamaguchi H, Fujimoto T, Nakamura S, Ohmura K, Mimori T, Matsuda F, Nagata S (2010)
Aberrant splicing of milk fat globule EGF factor 8 gene in human systemic lupus
erythematosus. Eur J Immunol. 40(6):1778-1785.
7) ○ Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N,
Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F,
27
Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K
(2010) A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
Nat Genet 42(6):515-9.
8) ○ Hashimoto M, Hirota K, Yoshitomi H, Maeda S, Teradaira S, Akizuki S, Prieto-Martin P,
Nomura T, Sakaguchi N, Köhl J, Heyman B, Takahashi M, Fujita T, Mimori T, Sakaguchi S
(2010) Complement drives Th17 cell differentiation and triggers autoimmune arthritis.
Med 207(6):1135-43.
J Exp
9) Tanaka Y, Takeuchi T, Mimori T, Saito K, Nawata M, Kameda H, Nojima T, Miyasaka N,
Koike T; for the RRR study investigators (2010) Discontinuation of infliximab after attaining
low disease activity in patients with rheumatoid arthritis: RRR (remission induction by
Remicade in RA) study. Ann Rheum Dis 69(7):1286-1291.
10) Yokoyama T, Usui T, Kiyama K, Terao C, Nakashima R, Yukawa N, Kawabata D, Nojima T,
Ohmura K, Fujii T, Mimori T (2010) Two cases of late-onset drug-induced lupus
erythematosus caused by ticlopidine in elderly men. Mod Rheumatol 20(4):405-9.
11) Fujimura T, Yukawa N, Nakashima R, Imura Y, Kawabata D, Nojima T, Ohmura K, Fujii T,
Usui T, Mimori T (2010) Periodic fever and erythema nodosum associated with MDS with
trisomy 8: Report of two cases and review of the literature. Mod Rheumatol 20(4):413-9.
12) Hoshino K, Muro Y, Sugiura K, Tomita Y, Nakashima R, Mimori T (2010) Anti-MDA5 and
anti-TIF1γ antibodies have clinical significance for patients with dermatomyositis.
Rheumatology (Oxford) 49(9):1726-33.
13) Tanaka M, Murakami K, Ozaki S, Imura Y, Tong XP, Watanabe T, Sawaki T, Kawanami T,
Kawabata D, Fujii T, Usui T, Masaki Y, Fukushima T, Jin ZX, Umehara H, Mimori T (2010)
DIP2 disco-interacting protein 2 homolog A (Drosophilla) is a candidate receptor for
follistatin-related protein/ follistatin-like 1. Analysis of their binding with TGF-β superfamily
proteins. FEBS J. 277(20):4278-89.
14) Nakashima R, Mimori T (2010) Clinical and pathophysiological significance of myositisspecific autoantibodies and myositis-associated antibodies. Int J Clin Rheumatol . 5(5):
523-536.
15) ○ Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K, Murasawa A, Honjo
S, Takasugi K, Tohma S, Matsuo K, Tajima K, Yukawa N, Kawabata D, Nojima T, Fujii T,
Yamada R, Saji H, Matsuda F, Mimori T (2010) Anti-citrullinated peptide antibody-negative
RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative
28
rheumatoid arthritis.
Rheumatology (Oxford). 49(12): 2298–2304.
16) Kang EH, Nakashima R, Mimori T, Kim J, Lee1 YJ, Lee EB, Song YW (2010) Myositis
autoantibodies in Korean patients with inflammatory myositis: Anti-140-kDa polypeptide
antibody is primarily associated with rapidly progressive interstitial lung disease independent
of clinically amyopathic dermatomyositis. BMC Musculoskelet Disord. 11(1):223.
17) Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima N, Ohmura
K, Usui T, Mimori T (2010) Anti-U1 RNP antibodies in cerebrospinal fluid are associated with
central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective
tissue disease. Arthritis Rheum. 62(12):3730-40.
2009
1) Satoh T, Ishikawa O, Ihn H, Endo H, Kawaguchi Y, Sasaki T, Goto D, Takahashi K, Takahashi
H, Misaki Y, Mimori T, Muro Y, Yazawa N, Sato S, Takehara K, Kuwana M (2009) Clinical
usefulness of anti-RNA polymerase III antibody measurement
immunosorbent assay. Rheumatology (Oxford) 48(12):1570-4.
by
enzyme-linked
2) Kobayashi K, Okamoto Y, Inoue H, Usui T, Ihara M, Kawamata J, Miki Y, Mimori T,
Tomimoto H, Takahashi R (2009) Leukoencephalopathy with cognitive impairment following
tocilizumab for the treatment of rheumatoid arthritis (RA). Intern Med. 48(15):1307-9.
3) Fujii T, Okada M, Fujita Y, Sato T, Tanaka M, Usui T, Umehara H, Mimori T (2009)
Vaccination with autoreactive CD4(+)Th1 clones in lupus-prone MRL/Mp-Fas(lpr/lpr) mice.
J Autoimmun. 33(2):125-34.
4) ○ Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T,
Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H,
Nojima T, Ohmura K, Fujii T, Mimori T (2009) Gamma/delta T cells are the predominant
source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid
arthritis. Arthritis Rheum. 60(8):2294-303.
5) ○ Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, Hashimoto H, Tokano Y, Mimori T,
Terao C, Matsuda F, Kuno T, Kumagai S (2009) Lack of association between tyrosine kinase 2
(TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. Mod
Rheumatol. 19(4):401-6.
6) Kitaori T, Ito H, Yoshitomi H, Aoyama T, Fujii T, Mimori T, Nakamura T (2009) Severe erosive
arthropathy requiring surgical treatments in systemic lupus erythematosus. Mod Rheumatol.
19(4):431-6.
29
7) Kondo T, Inoue H, Usui T, Mimori T, Tomimoto H, Vernino S, Takahashi R (2009)
Autoimmune autonomic ganglionopathy with Sjögren's syndrome: significance of ganglionic
acetylcholine receptor antibody and therapeutic approach. Auton Neurosci. 146(1-2): 33-5.
2008
1) Jin ZX, Huang CR, Dong L, Goda S, Kawanami T, Sawaki T, Sakai T, Tong XP, Masaki Y,
Fukushima T, Tanaka M, Mimori T, Tojo H, Bloom ET, Okazaki T, Umehara H. (2008)
Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1
(SMS1)-knockdown T cells. Int Immunol. 20(11):1427-37.
2) Fujita Y, Fujii T, Nakashima R, Tanaka M, Mimori T. (2008) Aseptic meningitis in mixed
connective tissue disease: cytokine and anti-U1RNP antibodies in cerebrospinal fluids from
two different cases. Mod Rheumatol. 18(2):184-8.
6) Tsutomu Chiba
1.
Kanda K, Komekado H, Sawabu T, Ishizu S, Nakanishi U, Nakatsuji M, Akitake-Kawano R,
Ohono M, Hiraoka Y, Kawada M, Kawada K, Sakai Y, Matsumoto K, Kunichika M, Kimura T,
Seno H, Nishi E, Chiba T: Nardilysin and ADAM proteases promote gastric cancer cell growth
by activating intrinsic cytokine signaling via enhanced ectodomain shedding of TNFα. EMBO
Mol Med 4:396-411:2012.
2.
Ueda Y, Marusawa H, Kaido T, Ogura Y, Oike F, Mori A, Ogawa K, Yoshizawa A, Hatano
E, Miyagawa-Hayashino A, Haga H, Egawa H, Takada Y, Uemoto S, Chiba T: Effect of
maintenance therapy with low-dose peginterferon for recurrent hepatitis C after living donor
liver transplantation. J Viral Hept 19:32-38:2012.
3.
Nishiura H, Kido M, Aoki N, Iwamoto S, Maruoka R, Ikeda A, Chiba T, Ziegler SF,
Watanabe N: Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin
receptor-deficient mice. J Immunol 188:190-197:2012.
4.
Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T,
Nakamura S, Kawa S, Hamano H, Kamisawa T, SHIMOSEGAWA T, Shimatsu A, Nakamura
S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi, Tsubouchi
H, Inui K, Ohara H: Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD),
2011. Mod Rheumatol 22:21-30:2012.
5.
Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S,
Ishiguro H, Chiba T: Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a
30
potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer
Chemother Pharmacol 69:65-70:2012.
6.
Koyasu S, Isoda H, Tsuji Y, Yamamoto H, Matsueda K, Watanabe Y, Chiba T, Togashi K.
Hepatic arterial perfusion increases in the early stage of severe acute pancreatitis patients:
Evaluation by perfusion computed tomography. Eur J Radiol 81:43-46:2012.
7.
Okuyama S, Marusawa H, Matsumoto T, Ueda Y, Matsumoto Y, Endo Y, Takai A, Chiba T．
Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2
(APOBEC2) contiributes to liver and lung tumorigenesis. Int J Cancer 130:1294-1301:2012.
8.
Iwamoto S, Kido M, Aoki N, Nishiura H, Maruoka R, Ikeda A, Okazaki T, Chiba T,
Watanabe N: IFN-γ is reciprocally involved in the concurrent development of organ-specific
autoimmunity in the liver and stomach. Autoimmunity 45:186-198:2012.
9.
○ Ueo T, Imayoshi T, Kobayashi T, Ohtsuka T, Seno H, Nakae H, Chiba T, Kageyama R:
The role of Hes genes in intestinal development, homeostasis and tumor formation.
Development 139:1071-1082:2012.
10.
Tsuji Y, Takahashi N, Chiba T: Pancreatic perfusion CT in early stage of severe acute
pancreatitis. Int J Inflamm 2012;doi 10.1155/497386.
11.
Watanabe T, Tsuji Y, Takahashi N, Yoshida T, Tamaoki M, Kikuchi O, Watanabe Y,
Kodama Y, Isoda H, Yamamoto H, Chiba T: Relationship between pancreatic perfusion
parameters and clinical complications of severe acute pancreatitis. Pancreas 2012 (in press).
12.
Umehara H, Okazaki K, Msaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T,
Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito
T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H,
Inui K, Ohara H: Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011.
Mod Rheumatol 22:21-30:2012.
13.
Watanabe T, Yamashita K, Fujikawa S, Sakurai T, Kudo M, Shiokawa M, Kodama Y,
Uchida K, Okazaki K, Chiba T: Involvement of activation of toll-like receptors and
nucleotide-binding oligomerization domain-like receptors in enhanced IgG4 responses in
autoimmune pancreatitis. Arthritis Rheum 64:914-924:2012.
14.
Takai A, Marusawa H, Minaki Y, Watanabe T, Nakase H, Kinoshita K, Tsujimoto G, Chiba
T. Targeting activation-induced cytidine deaminase prevents colon cancer development despite
persistent colonic inflammation. Oncogene 31:1733-1742:2012.
31
15.
Osaki Y, Ueda Y, Marusawa H, Nakajima J, Kimura T, Kita R, Nishikawa H, Saito S, Henmi
S, Sakamoto A, Eso Y, Chiba T: Decrease in alpha-fetoprotein levels predicts reduced
incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving
interferon therapy: a single center study. J Gastroenterol 47:444-451:2012.
16.
Muto M, Ezoe Y, Yano T, Aoyama I, Yoda Y, Minashi K, Morita S, Horimatsu T,
Miyamoto S, Ohtsu A, Chiba T: Usefulness of endoscopic radial incision and cutting method
for refractory esophagogastric anastomotic stricture (with video): Gastrointest Endosc
75:965-972:2012.
17.
Horimatsu T, Muto M, Yoda Y, Yano T, Ezoe Y, Miyamoto S, Chiba T: Tissue damage of
the canine normal esophagus by photoactivation of taraporfin sodium (Laserphyrin): A
preclinical study. PLoS one 7:e38308:2012.
18.
Ueda Y, Marusawa H, Kaido T, Ogura Y, Ogawa K, Yoshizawa A, Hata K, Fujimoto Y,
Nishijima N, Chiba T, Uemoto S: Efficacy and safety of prophylaxis with entecavir and
hepatitis B immunoglobulin in preventing hepatitis B recurrence after living-donor liver
transplantation: Hepatol Res 2012 (in press).
19.
Nishijima N, Marusawa H, Ueda Y, Takahashi K, Nasu A, Osaki Y, Kou T, Yazumi S,
Fujiwara T, Tsuchiya S, Shimizu K, Uemoto S, Chiba T: Dynamics of hepatitis B virus
quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep
sequencing: PLoS One 7:e35052:2012.
20.
Hori K, Miyamoto S, Yukawa Y, Muto M, Chiba T, Matsuda T: Stability of
acetaldehyde-derived DNA adduct in vitro. Biochem Biophy Res Commun 423:642-646:2012.
21.
Yukawa Y, Muto M, Hori K, Nagayoshi H, Yokoyama A, Chiba T, Matsuda T: Combination
of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the
blood of Japanese alcoholics. Cancer Sci 2012 (in press).
22.
Watanabe T, Yamashita K, Sakurai T, Kudo T, Shiokawa M, Uza N, Kodama Y, Uchida K,
Okazaki K, Chiba T: Toll-like receptor activation in basophils contributes to the development
of IgG4-related disease. J Gastroenterol 2012 (in press).
23.
Kawada M, Seno H, Kanda K, Nakanishi Y, Akitake R, Komekado H, Kawada K, Sakai Y,
Mizoguchi E, Chiba T: Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis
in colorectal cancer. Oncogene 31:3111-3123:2012.
32
24.
Yukawa Y, Muto M, Amanuma Y, Ezoe Y, Mashimo Y, Hori K, Horimatsu T, Morita S,
Miyamoto S, Minamiguchi S, Chiba T: Elimination of esophageal multiple precancerous
lesions by chemotherapy: potential chemoprevention of metachronous multiple cancer
development after curative treatment. Esophagus (in press).
25.
Tsuji Y, Watanabe T, Kudo M, Arai H, Strober W, Chiba T: Sensing of commensal
organisms by the intracellular sensor NOD1 mediates experimental pancreatitis. Immunity 37,
2012 (in press).
26.
Matsubara J, Honda K, Ono M, Tanaka Y, Kobayashi M, Jung G, Yanagisawa K, Sakuma T,
Nakamori S, Sata N, Nagai H, Ioka T, Okusaka T, Kosuge T, Tsuchida A, Shimahara M,
Yasunami Y, Chiba T, Hirohashi S, Yamada T: Reduced plasma level of CXC chemokine
ligand 7 in patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev
20:160–171:2011.
27.
Nakase H, Yoshino T, Matsumura K, Honzawa Y, Yamamoto S, Matsuura M, Chiba T.
Positive finding of colonic PCR for CMV-DNA is not false positive but warning for treating
patients with UC refractory to immunosuppressive therapies Inflammatory Bowel Disease
17:E13-4:2011
28.
Yoshino T, Nakase H, Matsuura M, Matsumura K, Honzawa Y, Fukuchi T, Watanabe K,
Murano M, Tsujikawa T, Fukunaga K, Matsumoto T, Chiba T. Effect and Safety of
Granulocyte-Monocyte adsorption apheresis for UC patients positive for cytomegalovirus in
comparison with immunosuppressants. Digestion 84:3-9:2011.
29.
Kishimoto M, Tsuji Y, Katabami N, Shimizu J, Lee KJ, Iwasaki T, Miyake Y, Yazumi S,
Chiba T, Yamada K. Measurement of canine pancreatic perfusion using dynamic computed
tomography: Influence of input-output vessels on deconvolution and maximum slope methods.
Eur J Radiol 77:175-181: 2011.
30.
Horimatsu T, Miyamoto S, Morita S, Mashimo Y, Ezoe Y, Muto M, Chiba T.
Pharmacokinetics of oxaliplatin in a hemodialytic patient treated with modified FOLFOX-6
plus bevacizumab therapy. Cancer Chemother Pharmacol 68:263-266:2011.
31.
Nakase H, Matsuura M, Chiba T. Potential role of granulocyte/monocyte adsorptive apheresis
for ulcerative colitis with concomitant CMV infection. Aliment Pharmacol Ther
33:497-498:2011.
32.
Kitamura H, Yamamoto S, Nakase H, Matsuura M, Honzawa Y, Matsumura K, Takeda Y,
Uza N, Nagata K, Chiba T. Role of heat shock protein 47 in intestinal fibrosis of experimental
33
colitis. Biochem Biophys Res Commun 404:599-604:2011.
33.
Alaboudy AA, Elbahrawy A, Matsumoto S, Yoshizawa A: Conventional narrow-band
imaging has good correlation with histopathological severity of Helicobacter pylori gastritis.
Dig Dis Sci 56:1127-1130: 2011.
34.
Uza N, Nakase H, Yamamoto S, Yoshino T, Takeda Y, Ueno S, Inoue S, Mikami S,
Matsuura M, Shimaoka T, Kume N, Minami M, Yonehara S, Ikeuchi H, Chiba T.
SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation. Gut
60:1494-1505:2011.
35.
Ueda Y, Marusawa H, Egawa H, Okamoto S, Ogura Y, Oike F, Nishijima N, Takada Y,
Uemoto S, Chiba T. De novo activation of HBV with escape mutations from hepatitis B
surface antibody after living donor liver transplantation. Antivir Ther 16:479-487:2011.
36.
Yamamoto S, Nakase H, Matsuura M, Masuda S, Inui K, Chiba T. Tacrolimus therapy as
an alternative to thiopurines for maintaining remission in patients with refractory ulcerative
colitis. J Clin Gastroenterol 45:526-530:2011.
37.
Aoki N, Kido M, Iwamoto S, Nishiura H, Maruoka R, Tanaka J, Watanabe T, Tanaka Y,
Okazaki T, Chiba T, Watanabe N. Dysregulated generation of follicular helper T cells in the
spleen triggers fatal autoimmune hepatitis in mice. Gastroenterology 140:1322-1333:2011.
38.
Shio S, Kodama Y, Ida H, Shiokawa M, Kitamura K, Hatano E, Uemoto S, Chiba T. Loss of
RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis.
Cancer Sci 102:776-783:2011.
39.
Takai A, Marusawa H, Chiba T: Acquisition of genetic aberrations by activation-induced
cytidine deaminase (AID) during inflammation–associated carcinogenesis. Cancers 3:
2750-2766: 2011.
40.
Chung H, Watanabe T, Kudo M, Chiba T. Correlation between hyporesponsiveness to
Toll-like receptor ligands and liver dysfunction in patients with chronic hepatitis C virus
infection. J Viral Hepatitis 18:e561-567:2011.
41.
Nasu A, Marusawa H, Ueda Y, Nishijima N, Takahashi K, Osaki Y, Yamashita Y, Inokuma
T, Tamada T, Fujiwara T, Sato F, Shimizu K, Chiba T. Genetic heterogeneity of hepatitis C
virus in association with antiviral therapy determined by ultra-deep sequencing. PLos One
6:e24907:2011.
34
42.
Honzawa Y, Nakase H, Matsuura M, Chiba T. Clinical significance of serum diamine oxidase
activity in inflammatory bowel disease. –importance of evaluation of small intestinal
permeability- Inflamm Bowel Dis 17:E23-E25:2011.
43.
Nakase H, Matsuura M, Uza N, Chiba T. Tacrolimus suppresses IL-12/IL-23p40 in Crohn’s
disease and heals fistulae refractory to anti-TNF-α therapy. Aliment Pharmacol Ther
33:979-980:2011.
44.
Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori
Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB. A phase
I/II study of gemcitabine-based chemotherapy plus curcumin for patients with
gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol 68:157-164:2011.
45.
○ Nakase H, Yamamoto S, Matsuura M, Chiba T. Tacrolimus ： rescue therapy or
experimental drugs for severe ulcerative colitis? Aliment Pharmacol Ther 33:413-414:2011.
46.
Hirota M, Tsuda M, Tsuji Y, Kanno A, Kikuta K, Kume K, Hamada S, Unno J, Ito H, Ariga
H, Chiba T, Masamune A, Satoh K, Shimosegawa T. Perfusion computed tomography findings
of autoimmune pancreatitis. Pancreas 40:1295-1301:2011.
47.
Muto M, Higuchi H, Ezoe Y, Horimatsu T, Morita S, Miyamoto S, Chiba T. Difference of
image enhancement in image-enhanced endoscopy: narrow band imaging versus flexible
spectral imaging color enhancement. J Gastroenterol 46:998-1002:2011.
48.
Muto M, Satake H, Yano T, Minashi K, Hayashi R, Fujii S, Ochiai A, Ohtsu A, Morita S,
Horimatsu T, Ezoe Y, Miyamoto S, Asato R, Tateya I, Yoshizawa A, Chiba T. Long-term
outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial
pharyngeal cancer. Gastrointest Endoscopy 74:477-484:2011.
49.
Takata K, Okada H, Ohmiya N, Nakamura S, Kitadai Y, Tari A, Akamatsu T, Kawai H,
Tanaka S, Araki H, Yoshida T, Okumura H, Nishisaki H, Sagawa T, Watanabe N, Arima N,
Takatsu N, Nakamura M, Yanai S, Kaya H, Morito T, Sato Y, Moriwaki H, Sakamoto C, Niwa
Y, Goto H, Chiba T, Matsumoto T, Ennishi D, Kinoshita T, Yoshino T. Primary
gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity:
A multicenter, retrospective analysis in Japan. Cancer Sci 102:1532-1536:2011.
50.
Ido A, Moriuchi A, Numata M, Murayama T, Teramukai S, Marusawa H, Yamaji N,
Setoyama H, Kim ID, Chiba T, Higuchi S, Yokode M, Fukushima M, Shimizu A, Tsubouchi H.
Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in
patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to
35
ensure safety. J Translational Med 9:55:2011.
51.
Nakase H,Uza N, Matsuura M, Chiba T. Importance of CXCL16 as a biomarker for
granulocytapheresis in patients with Crohn’s disease. Inflamm Bowel Dis 2211-2212:2011.
52.
Nakase H, Tamaki H, Matsuura M, Chiba T, Okazaki K. Involvment of mycobacterium
avium subspecies paratuberculosis with in TNF-α production from macrophage-possible link
between MAP and immune response in Crohn’s disease. Inflamm Bowel Dis
17:E140-E142:2011.
53.
Kido M, Watanabe N, Aoki N, Iwamoto S, Nishiura H, Maruoka R, Ikeda A, Azuma T,
Chiba T. Dual roles of CagA protein in Helicobacter pylori-induced chronic gastritis in mice.
Biophys Biochem Res Commun 412:266-272:2011.
54.
Morita S, Matsumoto Y, Okuyama S, Ono K, Kitamura Y, Tomori A, Oyama T, Amano Y,
Kinoshita Y, Chiba T, Marusawa H. Bile acid-induced expression of activation-induced
cytidine deaminase during the development of Barrett’s oesophageal adenocarcinoma.
Carcinogenesis 32:1706-1712:2011.
55.
Kanai M, Ishiguro H, Mori Y, Kitano T, Nishimura T, Matsumoto S, Yanagihara K, Chiba T,
Toi M. Temporary blood pressure drop after bevacizumab administration is associated with
clinical course of advanced colorectal cancer. Br J Cancer 105:1693-1696:2011.
56.
Marusawa H, Takai A, Chiba T: Role of activation-induced cytidine deaminase in
inflammation-associated cancer development. Adv Immunol 111:109-141:2011.
57.
Nakanishi Y, Nakatsuji M, Seno H, Ishizu S, Akitake-Kawano R, Kanda K, Ueo T,
Komekado H, Kawada M, Minami M, Chiba T: COX2 inhibition alters the phenotype of
tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. Carcinogenesis
32:1333-1339:2011.
58.
Watanabe T, Tsuji Y, Kodama Y, Isoda H, Yamamoto H, Chiba T: Relationship between
serum angiopoietin 2 level and perfusion CT parameters in severe acute pancreatitis. Am J
Gastroenterol 106:1859-1861: 2011.
59.
Fukui H, Sekikawa A, Tanaka H, Fujimori Y, Katake Y, Fujii S, Ichikawa K, Tomita S,
Imura J, Chiba T, Fujimori T: DMBT1 is a novel gene induced by IL-22 in ulcerative colitis.
Inflamm Bowel Dis 17:1177-1188:2011.
60.
Kanai M, Yoshimura K, Tsumura T, Asada M, Suzuki C, Niimi M, Matsumoto S, Nishimura
36
T, Nitta T, Yasuchika K, Taura K, Mori Y, Hamada A, Inoue N, Tada S, Yanagihara K,
Yazumi S, Osaki Y, Chiba T, Ikai I, Fukushima M, Uemoto S, Hatano E: A multi-institution
phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary
tract cancer. Cancer Chemother Pharmacol 67:1429-1434:2011.
61.
Matsubara J, Honda K, Ono M, Sekine S, Tanaka Y, Kobayashi M, Jung G, Sakuma T,
Nakamori S, Sata N, Nagai H, Ioka T, Okusaka T, Kosuge T, Tsuchida A, Shimahara M,
Yasunami Y, Chiba T, Yamada T: Identification of adipophilin as a potential plasma biomarker
for colorectal cancer using label-free quantitative mass spectrometry and protein microarray.
Cancer Epidemiol Biomarkers Prev 20:2195-2203:2011.
62.
Tanaka H, Fukui H, Fujii S, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J,
Yasuda Y, Chiba T, Fujimori T. Immunohistochemical analysis of REG Iα expression in
ulcerative colitis-associated neoplastic lesions. Digestion 83:204-209:2011.
63.
Yamada A, Fujii S, Daiko H, Nishimura M, Chiba T, Ochiai A: Aberrant expression of EZH2
is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the
esophagus. Int J Oncol 38:345-353:2011.
64.
Nishio A, Asada M, Uchida K, Fukui T, Chiba T, Okazaki K: The role of innate immunity in
the pathogenesis of experimental autoimmune pancreatitis in mice. Pancreas 40:95-102:2011.
65.
S-K, Kim, Marusawa H, Eso Y, Nishikawa H, Ueda Y, Kita R, Kimura T, Chiba T, Osaki Y,
Kudo M: Clinical characteristics of non-B non-C hepatocellular carcinoma: A single-center
retrospective study. Digestion 84:43-49:2011.
66.
Endo Y, Marusawa H, Chiba T: Involvement of activation-induced cytidine deaminase in the
development of colitis-associated colorectal cancers. J Gastroenterol 46 (Suppl 1):6-10:2011.
67.
Kido M, Tanaka J, Aoki N, Iwamoto S, Nishiura H, Chiba T, Watanabe N: Helicobacter
pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and
induces dendritic cell-mediated inflammatory Th2 responses. Infect Immun 78:108-114: 2010.
68.
Matsumura K, Nakase H, Chiba T. Efficacy of Oral Tacrolimus on Inetestinal Behcet’s
Disease. Inflamm Bowel Disease 16:188-189:2010.
69.
Matsunaka T, Miyamoto S, Shitara K, Ochiai A, Chiba T: Ligand-specific antibodies to
insulin-like growth factors suppress intestinal polyp formation in apc +/- mice. Mol cancer
Ther 9:419-428:2010.
37
70.
Nakase H, Chiba T: TNFα is an important pathogenic factor contributing to reactivation of
cytomegalovirus in inflamed mucosa of colon in patients with ulcerative colitis: Lesson from
clinical experience. Inflamm Bowel Dis 16:550-551:2010.
71.
Yamamoto S, Nakase H, Yamashita K, Matsuura M, Takada M, Kawanami C, Chiba T:
Gastrointestinal follicular lymphoma: Review of the literature. J Gastroenterol
45:370-388:2010.
72.
Tanaka J, Saga K, Kido M, Nishiura H, Akamatsu T, Chiba T, Watanabe N. Proinflammatory
Th2 cytokines induce production of thymic stromal lymphopoietin in human colonic epithelial
cells: Dig Dis Sci 55:1896-1904:2010.
73.
Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui
T, Okazaki K, Chiba T. Analysis of Humoral Immune Response in Experimental Autoimmune
Pancreatitis in Mice. Pancreas 39:224-231: 2010.
74.
Marusawa H, Chiba T: Helicobacter pylori-induced activation-induced cytidine deaminase
expression and carcinogenesis. Curr Opi Immunol 22:442-447:2010.
75.
Akitake R, Nakase H, Tamaoki M, Ueno S, Mikami S, Chiba T. Modulation of Th1/Th2
balance by Infliximab Rescues Postoperative Occurrence of Small-Intestinal Inflammation
Associated with Ulcerative Colitis. Dig Dis Sci 55:1781-1784:2010.
76.
Ezoe Y, Muto M, Horimatsu T, Minashi K, Yano T, Chiba T, Ohtsu A: Magnifying
narrow-band imaging versus magnifying white-light imaging for differential diagnosis of
gastric small depressive lesions: A prospective study. Gastrointest Endosc 71:477-484:2010.
77.
Ueda Y, Takada Y, Marusawa H, Haga H, Sato T, Tanaka Y, Egawa H, Uemoto S, Chiba T:
Clinical features of biochemical cholestasis in patients with recurrent hepatitis C after
living-donor-liver transplantation. J Viral Hep 17:481-487:2010.
78.
Akitake R, Watanabe T, Zaima C, Uza N, Ida H, Tada S, Nishida N, Chiba T: Possible
involvement of T helper Type 2 responses to toll -like receptor ligands in IgG4-related
sclerosing disease. Gut 59:542-545: 2010.
79.
Yamamoto S, Nakase H, Matsuura M, Honzawa Y, Masuda S, Inui K, Chiba T: Efficacy and
safty of infliximab as rescue therapy for ulcerative colitis refractory to tacrolimus. J
Gastroenterol Hepatol 25:886-891:2010.
80.
○ Nakase H, Fujiyama Y, Oshitani N, Oga T, Nonomura K, Matsuoka T, , Murayama T,
38
Teramukai S, Chiba T, Narumiya S. Effect of EP4 agonist (ONO-4819CD) for patients with
mild to moderate ulcerative colitis refractory to 5-aminosalicylates: A randomized phase 2,
placebo-controlled trial. Inflamm Bowel Dis 16:731-733:2010.
81.
Kanai M, Yoshioka A, Tanaka S, Nagayama S, Matsumoto S, Nishimura T, Niimi M,
Teramukai S, Takahashi R, Mori Y, Kitano T, Ishiguro H, Yanagihara K, Chiba T, Fukushima
M, Matsuda F: Associations between glutathione S-transferase π Ile105Val and glyoxylate
aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced
neuropathy. Cancer Epidem 34:189-193:2010.
82.
Kanai M, Matsumoto S, Nishimura T, Matsumura Y, Hatano E, Mori A, Masui T, Kawaguchi
Y, Nakamura E, Tada S, Kitano T, Ishiguro H, Yanagihara K, Chiba T: Premedication with 20
mg dexamethasone effectively prevents relapse of extensive skin rash associated with
gemcitabine monotherapy. Ann Oncol 21:189-190:2010.
83.
Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss
IJ, Kitani A, Strober W: NOD1 contributes to mouse host defense against Helicobacter pylori
via induction of type I IFN and activation of the ISGF3 signaling. J Clin Invest
120:1645-1662:2010.
84.
Chung H, Watanabe T, Kudo M, Maenishi O, Wakatsuki Y, Chiba T: Identification and
characterization of IgG4-associated autoimmune hepatitis. Liver Int 30:222-231:2010.
85.
Honzawa Y, Nakase H, Takeda Y, Nagata K, Chiba T: Heat shock protein 47 can be a new
target molecule for intestinal fibrosis related to inflammatory bowel disease. Inflam Bowel Dis
16:2004-2006:2010.
86.
Nasu A, Marusawa H, Ueda Y, Eso Y, Umeda M, Chiba T, Osaki Y. De novo hepatitis B
virus infection in hepatocellular carcinoma that developed after eradication of hepatitis C virus
by interferon therapy. Hepatology Research 40:661-665:2010
87.
Matsubara J, Ono M, Honda K, Negishi A, Ueno H, Okusaka T, Furuse J, Furuta K,
Sugiyama E, Saito Y, Kamiwa N, Sawada J, Shoji A, Sakuma T, Chiba T, Saijo N, Hirohashi S,
Yamada T: Survival prediction for pancreatic cancer patients receiving gemcitabine treatment.
Mol Cell Proteomics 9:695-704:2010
88.
Nakase H, Honzawa Y, Chiba T. Heat shock protein 47 is a new candidate molecule as
anti-fibrotic treatment of Crohn’s disease. Aliment Pharmacol Ther 31:926-927:2010.
89.
Nakase H, Yoshino T, Honzawa Y, Chiba T. Low prevalence of CMV infection in patients
39
with Crohn’s disease in comparison with ulcerative colitis-effect of different immune response
on prevalence of CMV infection- Dig Dis Sci 55:1498-1499:2010.
90.
Chiba T, Marusawa H, Seno H, Watanabe N: H.pylori infection –The route from
inflammation to cancer. In Sansonetti P, ed, Infection Biology Handbook Series. Bacterial
Virulence. Basic principles, models and global approaches. Willey-Blackwell 2010:31-41.
91.
Nakase H, Yamamoto S, Matsuura M, Honzawa Y, Chiba T. Cytomegalovirus affects clinical
outcome of infliximab therapy on patients with ulcerative colitis refractory to tacrolimus.
Aliment Pharmacol Ther. 32:510-511:2010.
92.
○ Matsumoto Y, Marusawa H, Kinoshita K, Niwa Y, Sakai Y, Chiba T: Up-regulation of
activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in
gastric cancer. Gastroenterology 139:1984-1994:2010.
93.
Sawai Y, Yamao K, Bhatia V, Chiba T, Mizuno N, Sawaki A, Takahashi K, Tajika M,
Shimizu Y, Yatabe Y, Yanagisawa A: Development of pancreatic cancers during long-term
follow-up of side branch intraductal papillary-mucinous neoplasms. Endoscopy
42:1077-1084:2010
94.
Tsuji Y, Hamaguchi K, Watanabe Y, Okumura A, Isoda H, Yamamoto N, Kikuchi O,
Yamamoto H, Matsuda K, Ueno K, Tada S, Togashi K, Yamamoto H, Chiba T: Perfusion CT
is superior to angiography in predicting pancreatic necrosis in patients with severe acute
pancretitis. J Gastroenterol 45:1155-1162:2010.
95.
Chung H, Watanabe T, Kudo M, Chiba T: Hepatitis C virus core protein induces homo- and
cross-tolerance to Toll-like receptor ligands via activation of Toll-like receptor 2. J Infect Dis
202:853-861:2010.
96.
Yoshino T, Nakase H, Honzawa Y, Matsumura K, Yamamoto S, Takeda Y, Ueno S, Uza N,
Masuda S, Inui K, Chiba T: Immunosuppressive effects of tacrolimus on macrophages
ameliorate experimental colitis. Inflamm Bowel Dis 16:2022-2033:2010.
97.
Ueda Y, Takada Y, Marusawa H, Egawa Y, Uemoto S, Chiba T: Individualized extension of
pegylated interferon plus ribavirin therapy for reccurrent Hepatitis C genotype Ib after
living-donor liver transplantation. Transplantation 90:661-665:2010.
98.
Fukuhara M, Watanabe T, Ueo T, Ida H, Kodama Y, Chiba T: Enhanced cytokine responses
to Toll-like and NOD-like receptor ligands in primary biliary cirrhosis-CREST overlap
syndrome. Rheumatology 49:1602-1604:2010.
40
99.
○ Nishio M, Sakakura C, Nagata T, Komiyama S, Miyashita A, Hamada T, Kuryu T, Ikoma
H, Kubota T, Kimura A, Nakanishi M, Ichikawa D, Fujiwara H, Okamoto K, Ochiai T, Kokubo
Y, Sonoyama T, Ida H, Ito K, Chiba T, Ito Y, Otsuji E. RUNX3 promoter methylation in
colorectal cancer: its relationship with microsatellite instability and its suitability as a novel
serum tumor marker. Anticancer Res 30:2673-2682:2010.
100.
Nakase H, Chiba T. TNF-alpha is an important pathogenic factor contributing to
reactivation of cytomegalovirus in inflamed mucosa of colon in patients with ulcerative colitis:
lesson from clinical experience. Inflamm Bowel Dis 16:550-551:2010.
101.
Sekikawa A, Fukui H, Suzuki K, Karibe T, Fujii S, Ichikawa K, Tomita S, Imura J, Shiratori
K, Chiba T, Fujimori T: Involvement of IL-22/REGIα axis in ulcerative colitis. Lab Invest
90:496-505:2010.
102.
Watanabe T, Asano N, Kitani A, Fuss IJ, Chiba T, Strober W. NOD1-mediated mucosal
host defense against Helicobacter pylori. Int J Inflam 2010. article No:476482;doi
10.4061.2010.
103.
Tanaka J, Watanabe N, Kido M, Saga K, Akamatsu T, Nishio A, Chiba T: Human TSLP and
TLR3 ligand promote differentiation of Th17 cells with central memory phenotype under
Th2-polarizing conditions. Clin Exp Allergy 39:89-100:2009.
104.
Wada M, Marusawa H, Yamada R, Nasu A, Osaki Y, Kudo M, Nabeshima M, Fukuda Y,
Chiba T, Matsuda F: Association of genetic polymorphism with interferon-induced
hematologic adverse effects in chronic hepatitis C patients. J Viral Hepat 16:388-396:2009.
105.
Muto M, Horimatsu T, Ezoe Y, Hori K, Yukawa Y, Morita S, Miyamoto S, Chiba T:
Narrow-band imaging of the gastrointestinal tract. J Gastroenterol 44:13-25:2009.
106. Kuwabara A, Tanaka K, Tsugawa H, Nakase H, Tsuji H, Shide K, Kamao M, Chiba T,
Inagaki N, Okano T, Kido S: High prevalence of vitamin K and D deficiency and decreased
BMD in inflammatory bowel disease. Osteoporos Int 20:935-42:2009.
107.
Takeda Y, Nakase H, Chiba T: Up-regulation of T-bet and tight junction molecules by
Bifidobactrium longum improves colonic inflammation of ulcerative colitis: Inflam Bowel Dis
15:1617-18:2009.
108. Inoue S, Nakase H, Matsuura M, Mikami S, Ueno S, Uza N, Chiba T: The effect of
proteasome inhibitor MG-132 on experimental inflammatory bowel disease. Clin Exp Immunol
41
156:172-182: 2009.
109.
Nakase H, Mikami S, Chiba T: Alteration of CXCR4 expression and Th1/Th2 balance of
peripheral CD4 positive T cells can be a biomarker for leukocytapheresis therapy for patients
with refractory ulcerative colitis. Inflamm Bowel Dis 15:963-964:2009.
110. ○ Takai A, Toyoshima T, Uemura M, Kitawaki Y, Marusawa H, Hiai H, Yamada S,
Okazaki I, Honjo T, Chiba T, Kinoshita K: A novel mouse model of hepatocarcinogenesis
triggered by AID causing deleterious p53 mutations. Oncogene 28:469-478:2009.
111.
Ueda Y, Marusawa H, Ichinohe T, Kadowaki N, Uchiyama T, Chiba T: Effective treatment
for de novo hepatitis B with nucleotide analogue in patients with hematological malignancies.
Am J Hematol 84:315-316:2009.
112.
El-Sherif A, Abou-Shady M, Abou-Zeid H, Elwassief A, Elbarhrawy A, Ueda Y, Chiba T,
Hosney A: Antibody to hepatitis B core antigen as a screening test for occult hepatitis B virus
infection in Egyptian chronic hepatitis C patients. J Gastroenterol 44:359-364:2009.
113. Ikeuchi K, Marusawa H, Fujiwara M, Matsumoto Y, Endo Y, Watanabe T, Iwai A, Sakai Y,
Takahashi R, Chiba T: Attenuation of proteolysis-mediated cyclin E regulation by alternatively
spliced Parkin in human colorectal cancers. Int J Cancer 125:2029-2035:2009.
114.
Matsubara J, Ono M, Negishi A, Ueno H, Okusaka T, Fruse J, Furuta K, Sugiyama E, Saito
Y, Kaniwa N, Sawada J, Honda K, Sakuma T, Chiba T, Saijo N, Hirohashi S, Yamada T:
Identification of a predictive biomarker for hematologic toxicities of Gemcitabine. J Clin Oncol
27:2261-2268:2009.
115.
Yamagishi H, Fukui H, Sekikawa A, Kono T, Fujii S, Ichikawa K, Tomita S, Imura J,
Hiraishi H, Chiba T, Fujimori T: Expression profile of REG family proteins, REG Iα and
REGIV in advanced gastric cancer: Comparison with mucinous phenotype and prognostic
markers. Modern Pathol 22: 906-913:2009.
116.
Chiba T, Marusawa H: A novel mechanism for inflammation-associated carcinogenesis; an
important role of activation-induced cytidine deaminase (AID) in mutation induction. J Mol
Med 87:1023-1027:2009.
117. Matsui H, Watanabe T, Ueno K, Ueno S, Matsumura K, Nakatsuji M, Ueda Y, Chiba T:
Colonic polyposis associated with autoimmune pancreatitis. Pancreas 38:840-842:2009.
118.
Sakuraba A, Motoya S, Watanabe K, Nishishita M, Kanke K, Matsui T, Suzuki Y, Oshima T,
42
Kunisaki R, Matsumoto T, Hanai H, Fukunaga K, Yoshimura N, Chiba T, Funakoshi S,
Aoyama N, Andoh A, Nakase H, Mizuta Y, Suzuki R, Akamatsu T, Iizuka M, Ashida T, Hibi T.
An open-label prospective randomized multicenter study shows very rapid remission of
ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with
routine weekly treatment. Am J Gastroenterol. 104:2990-5:2009.
119.
Kimura T, Fukui H, Sekikawa A, Yamaguchi H, Ichikawa K, Tomita S, Fujii S, Imura J,
Kawamata H, Chiba T, Imai Y, Fujimori T: Involvement of REG Iα protein in the regeneration
of ductal epithelial cells in the minor salivary glands of patients with Shogrens syndrome Clin
Exp Immunol 155:16-20;2009.
120. ○ Sakakura C, Hamada T, Miyagawa K, Nishio M, Miyashita A, Nagata H, Ida H, Yazumi S,
Otsuji E, Chiba T, Ito K, Ito Y. Quantitative analysis of tumor-derived methylated RUNX3
sequences in the serum of gastric cancer patients. Anticancer Res 29:2619-2625:2009.
121.
Matsumura K, Nakase H, Yamamoto S, Yoshino T, Takeda Y, Kasahara K, Ueno S, Uza N,
Chiba T: Modulation of the Th1/Th2 balance by infliximab improves hyperthyroidism
associated with flare-up of ulcerative colitis. Inflamm Bowel Dis 15:967-968:2009.
122.
Watanabe N, Kiriya K, Chiba T: Small intestine Peyer’s patches are major induction sites of
the Helicobacter-induced host immune responses. Gastroenterology 134:642-643:2008.
123. ○ Aoi T, Yae K, Nakagawa M, Ichisaka T, Okita K, Takahashi K, Chiba T, Yamanaka S:
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science
321:699-702:2008 (published on line 14 February, 2008).
124.
Matsumoto T, Iida M, Motoya S, Haruma K, Suzuki Y, Kobayashi K, Ito H, Miyata M,
Kusunoki M, Chiba T, Yamamoto S, Hibi T: Therapeutic efficacy of infliximab on patients
with short duration of Crohn’s disease: A Japanese multicenter survey. Dis Colon Rectum
43:916-923:2008.
125. Komori J, Marusawa H, Machimoto T, Endo Y, Kinoshita K, Kou T, Haga H, Ikai I, Uemoto
S, Chiba T: Activation-induced cytidine deaminase links bile duct inflammation to human
cholangiocarcinoma. Hepatology 47:888-896:2008.
126.
Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T, Fujimori T: REG Iα
protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells.
Carcinogenesis 29:76-83:2008.
127. Akamizu T, Iwakura H, Ariyasu H, Hosoda H, Murayama T, Yokode M, Teramukai S, Seno
43
H, Chiba T, Noma S, Nakai Y, Fukunaga M, Nakai Y, Kangawa K, FD Clinical Study Team:
Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food
intake and appetite. Eur J Endocrinology 158;491-498:2008.
128.
Watanabe T, Kudo M, Chiba T, Wakatsuki Y: Molecular mechanisms of portal vein
tolerance. Hepatol Res38:441-449:2008.
129. ○ Iwai A, Hijikata M, Hishiki T, Isono O, Chiba T, Shimotohno K: Coiled-coil domain
containing 85B suppresses the β-catenin activity in a p53-dependent manner. Oncogene
27:1520-1526:2008
130. ○ Kido M, Watanabe N, Okazaki T, Akamatsu T, Tanaka J, Saga K, Nishio A, Honjo T,
Chiba T: Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory
T cells and PD-1-mediated signaling. Gastroenterology 135:1333-1343:2008.
131. ○ Endo Y, Marusawa H, Kou T, Nakase H, Fujii S, Fujimori T, Kinoshita K, Honjo T,
Chiba T: Activation-induced cytidine deaminase links between inflammation and the
development of colitis-associated colorectal cancers. Gastroenterology 135:889-898:2008.
132. ○ Morisawa T, Marusawa H, Ueda Y, Iwai A, Okazaki IM, Honjo T, Chiba T:
Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine
deaminase expression. Int J Cancer 123; 2735-40:2008.
133.
Fujiwara M, Marusawa H, Wang HQ, Iwai A, Ikeuchi K, Imai Y, Kataoka A, Nukina N,
Takahashi R, Chiba T: Parkin as a tumor suppressor gene for hepatocellular carcinoma.
Oncogene 27:6002-6011:2008.
134.
Yoshino T, Nakase H, Mikami S, Nio M, Ueno S, Uza N, Ohmori K, Manabe T, Chiba
T:Importance of diagnosis of concomitant cytomegalovirus infection in patients with intestinal
Behcet’s disease. Inflamm Bowel Dis 14:877-878:2008.
135.
Shio S, Yazumi S, Ogawa K, Hasegawa K, Tsuji Y, Kida M, Yamauchi J, Ida H, Tada S,
Uemoto S, Chiba T: Biliary complications in donors for living-donor liver transplantation. Am
J Gastroenterol 103:1393-1398: 2008.
136.
Yamamoto S, Nakase H, Mikami S, Inoue S, Yoshino T, Takeda Y, Kasahara K, Ueno S,
Uza N, Kitamura H, Tamaki H, Matsuura M, Inui K, Chiba T: Long-term effect of tacrolimus
therapy in patients with refractory ulcerative colitis. Aliment Pharmacol Ther 28:589-597:2008.
137.
Ueno K, Watanabe T, Kawata Y, Gotoh T, Tsuji Y, Ida H, Tada S, Yazumi S, Chiba T:
44
IgG4-related autoimmune pancreatitis involving the colonic mucosa. Eur J Gastroenterol
Hepatol 20:1118-1121:2008.
138. Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M,
Terao M, Doi R, Wright C, Hoshino M, Chiba T, Uemoto S: Reduction of Ptf1a gene dosage
causes pancreatic hypoplasia and diabetes in mice. Diabetes 57:2421-31:2008.
139.
Ueda Y, Takada Y, Haga H, Nabeshima M, Marusawa H, Ito T, Egawa H, Tanaka K,
Uemoto S, Chiba T: Limited benefit of biochemical response to combination therapy for
patients with recurrent hepatitis C after living-donor liver transplantation. Transplantation
85:855-862:2008.
140. Chiba T, Marusawa H, Seno H, Watanabe N: Mechanism for gastric cancer development by
Helicobacter pylori ifection. J Gastroenterol Hepatol 23:1175-1181:2008.
141. ○ Mikami S, Nakase H, Yamamoto S, Takeda Y, Yoshino T, Kasahara K, Ueno S, Uza N,
Oishi S, Fujii N, Nagasawa T, Chiba T: Blockade of CXCL12/CXCR4 axis ameliorates murine
experimental colitis. J Pharmacol Exp Ther 327:383-392:2008.
142. Vorobjova T, Watanabe T, Chiba T: Helicobacter pylori immunology and vaccines.
Helicobacter 13(Suppl 1):18-22:2008.
143.
Tamaki H, Nakase H, Matsuura M, Inoue S, Mikami S, Ueno S, Uza N, Kitamura H,
Kasahara K, Chiba T: The effect of tacrolimus (FK-506) on Japanese patients with refractory
Crohn’s disease. J Gastroenterol 43:774-779:2008.
144.
Akamatsu T, Watanabe N, Kido M, Saga K, Tanaka J, Kuzushima K, Nishio A, Chiba T:
Human TSLP directly enhances expansion of CD8+ T cells. Clin Exp Immunol
154:98-106:2008.
145.
Nakase H, Matsumura K, Yoshino T, Chiba T: Systematic review: cytomegalovirus infection
in inflammatory bowel disease. J Gastroenterol 43:735-740:2008.
146.
Takeda Y, Nakase H, Mikami S, Inoue T, Satou S, Sakai Y, Chiba T : Possible link
Between Ulcerative Colitis and In situ Adenocarcinoma of an Appendiceal Mucolece:
Importance of Inflammation in the Appendiceal Orfice Related to UC. Inflamm Bowel Dis
14:873-874:2008.
147.
Ido A, Moriuchi A, Marusawa H, Ikeda K, Numata M, Yamaji N, Setoyama H, Ida H,
Oketani M, Chiba T, Tusbouhi H: Translational research on HGF:A phase I/II study of
45
recombinant human HGF for the treatment of fulminant hepatic failure. Hepatol Res
38:S88-92:2008.
148.
Ikeda K, Marusawa H, Chiba T: Association between body mass index and diabetes and
hepatocellular carcinoma. Ann Int Med 148:166-167:2008.
149. ○ Yamada A, Sakaki H, Aoyagi K, Sano M, Fujii S, Daiko H, Nishimura M, Yoshida T,
Chiba T, Ochiai A: Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous
cell carcinoma of the esophagus Oocol Rep 20:1021-1027:2008
150. ○ Kimura T, Fukui H, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Fujii S, Imura J,
Kawamata H, Chiba T, Imai Y, Fujimori T: Involvement of REGIα protein in the regeneration
of ductal epithelial cells in the minor salivary glands of patients with Sjogren’s syndrome. Clin
Exp Immunol 155:16-20:2008.
7) Makoto Noda
1.
Kawashima S, Imamura Y, Chandana EP, Noda T, Takahashi R, Adachi E, Takahashi C, Noda
M (2008) Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular
junctions. J Neurochem 104(2): 376-385
2.
Lee H, Lim C, Lee J, Kim N, Bang S, Min B, Park G, Noda M, Stetler-Stevenson WG, Oh J
(2008) TGF-beta signaling preserves RECK expression in activated pancreatic stellate cells. J
Cell Biochem 104(3): 1065-1074
3.
Ohne Y, Takahara T, Hatakeyama R, Matsuzaki T, Noda M, Mizushima N, Maeda T (2008)
Isolation of hyperactive mutants of mammalian target of rapamycin. J Biol Chem 283(46):
31861-31870
4.
Hatta M, Matsuzaki T, Morioka Y, Yoshida Y, Noda M (2009) Density- and serum-dependent
regulation of the Reck tumor suppressor in mouse embryo fibroblasts. Cell Signal 21(12):
1885-1893
5.
Morioka Y, Monypenny J, Matsuzaki T, Shi S, Alexander DB, Kitayama H, Noda M (2009)
The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and
anterior-posterior polarity in fibroblasts. Oncogene 28(11): 1454-1464
6.
Omura A, Matsuzaki T, Mio K, Ogura T, Yamamoto M, Fujita A, Okawa K, Kitayama H,
Takahashi C, Sato C, Noda M (2009) RECK forms cowbell-shaped dimers and inhibits matrix
metalloproteinase-catalyzed cleavage of fibronectin. J Biol Chem 284(6): 3461-3469
46
7.
Shamma A, Takegami Y, Miki T, Kitajima S, Noda M, Obara T, Okamoto T, Takahashi C
(2009) Rb Regulates DNA damage response and cellular senescence through E2F-dependent
suppression of N-ras isoprenylation. Cancer Cell 15(4): 255-269
8.
Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J,
Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y,
Matsuzaki T, Noda M (2010) Involvement of the Reck tumor suppressor protein in maternal
and embryonic vascular remodeling in mice. BMC Dev Biol 10(1): 84
9.
Kimura T, Okada A, Yatabe T, Okubo M, Toyama Y, Noda M, Okada Y (2010) RECK is
up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage. Am J
Pathol 176(6): 2858-2867
10. Kitajima S, Miki T, Takegami Y, Kido Y, Noda M, Hara E, Shamma A, Takahashi C (2010)
Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth
factor receptor signaling. Oncogene 30(6): 737-750
11. Loayza-Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H, Noda M (2010) Hypoxia
and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK
tumor-suppressor protein through microRNAs. Oncogene 29(18): 2638-2648
12. Matsumoto N, Taguchi A, Kitayama H, Watanabe Y, Ohta M, Yoshihara T, Itokazu Y, Dezawa
M, Suzuki Y, Sugimoto H, Noda M, Ide C (2010) Transplantation of cultured choroid plexus
epithelial cells via cerebrospinal fluid shows prominent neuroprotective effects against acute
ischemic brain injury in the rat. Neurosci Lett 469(3): 283-288
13. Miki T, Shamma A, Kitajima S, Takegami Y, Noda M, Nakashima Y, Watanabe K, Takahashi
C (2010) The beta1-integrin-dependent function of RECK in physiologic and tumor
angiogenesis. Mol Cancer Res 8(5): 665-676
14. ○ Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S,
Kawazoe Y, Hiraoka M, Uesugi M, Noda M (2010) A novel screen using the Reck tumor
suppressor gene promoter detects both conventional and metastasis-suppressing anticancer
drugs. Oncotarget 1(4): 252-264
15. Noda M, Takahashi C, Matsuzaki T, Kitayama H (2010) What we learn from transformation
suppressor genes: lessons from RECK. Future Oncol 6(7): 1105-1116
16. ○ Wang H, Imamura Y, Ishibashi R, Chandana EP, Yamamoto M, Noda M (2010) The Reck
47
tumor suppressor protein alleviates tissue damage and promotes functional recovery after
transient cerebral ischemia in mice. J Neurochem 115(2): 385-398
17. ○ Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H,
Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda
M (2012) The transformation suppressor gene Reck is required for postaxial patterning in
mouse forelimbs. Biology Open 1(5): 458-466
18. Yoshida Y, Ninomiya K, Hamada H, Noda M (2012) Involvement of the SKP2-p27(KIP1)
pathway in suppression of cancer cell proliferation by RECK. Oncogene in press
8) Makoto Mark Taketo
1. Bagheri-Fam, S., Sim, H., Bernard, P., Jayakody, I., Taketo, M.M., Scherer, G., Harley, V.R.
Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol 2008, 314 :71-83.
2. Dunty, W.C., Jr., Biris, K.K., Chalamalasetty, R.B., Taketo, M.M., Lewandoski, M., Yamaguchi,
T.P. Wnt3a/ β-catenin signaling controls posterior body development by coordinating
mesoderm formation and segmentation. Development 2008, 135: 85-94.
3. Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S,
Schmidt-Ullrich R, Taketo, M.M., Morrisey EE, Atit R, Dlugosz AA, Millar SE.
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008,
313:210-24.
4. Chassot, A.A., Ranc, F., Gregoire, E.P., Roepers-Gajadien, H.L., Taketo, M.M., Camerino, G.,
de Rooij, D.G., Schedl, A., Chaboissier, M.C. Activation of β-catenin signaling by Rspo1
controls differentiation of the mammalian ovary. Hum. Mol. Genet. 2008, 17:1264-1277.
5. Närhi, K., Järvinen, E., Birchmeier, W., Taketo, M.M., Mikkola, M.L., Thesleff, I. Sustained
epithelial β-catenin activity induces precocious hair development but disrupts hair follicle
down-growth and hair shaft formation. Development, 2008, 135:1019-1028.
6. ○ Turner, N., Li, J.Y., Gosby, A., To, S.W., Cheng, Z., Miyoshi, H., Taketo, M.M., Cooney,
G.J., Kraegen, E.W., James, D.E., Hu, L.H., Li, J., Ye, J.M. Berberine and its more biologically
available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a
mechanism for the action of berberine to activate AMP-activated protein kinase and improve
insulin action. Diabetes, 2008, 57:1414-1418.
7. Yamanaka, Y., Heike, T., Kumada, T., Shibata, M., Takaoka, Y., Kitano, A., Shiraishi, K., Kato,
48
T., Nagato, M., Okawa, K., Furushima, K., Nakao, K., Nakamura, Y., Taketo, M.M., Aizawa,
S., Nakahata, T. Loss of Borealin/DasraB leads to defective cell proliferation, p53
accumulation and early embryonic lethality. Mech. Dev. 2008, 125:441-450.
8. Reynolds, S.D., Zemke, A.C., Giangreco, A., Brockway, B.L., Teisanu, R.M., Drake, J.A.,
Mariani, T., Di, P.Y., Taketo, M.M., Stripp, B.R. Conditional stabilization of β-catenin
expands the pool of lung stem cells. Stem Cells, 2008, 26:1337-1346.
9. Barrionuevo, F., Naumann, A., Bagheri-Fam, S., Speth, V., Taketo, M.M., Scherer, G., Neubüser,
A. Sox9 is required for invagination of the optic placode in mice. Dev. Biol. 2008,
317:213-224.
10. Chang, H., Gao, F., Guillou, F., Taketo, M.M., Huff, V., Behringer, R.R. Wt1 negatively
regulates β-catenin signaling during testis development. Development, 2008, 135:1875-1885.
11. Zhang, Y., Andl, T., Yang, S.H., Teta, M., Liu, F., Seykora, J.T., Tobias, J.W., Piccolo, S.,
Schmidt-Ullrich, R., Nagy, A., Taketo, M.M., Dlugosz, A.A., Millar, S.E. Activation of
β-catenin signaling programs embryonic epidermis to hair follicle fate. Development, 2008,
135:2161-2172.
12. Burns, C.J., Zhang, J., Brown, E.C., van Bibber, A.M., van Es, J., Clevers, H., Ishikawa, T.O.,
Taketo, M.M., Vetter, M.L., Fuhrmann, S. Investigation of Frizzled-5 during embryonic neural
development in mouse. Dev. Dyn. 2008, 237:1614-1626.
13. Guo, X., Oshima, H., Kitamura, T., Taketo, M.M., Oshima, M. Stromal fibroblasts activated by
tumor cells promote angiogenesis in mouse gastric cancer. J. Biol. Chem.
2008,
283:19864-19871.
14. Oguma, K., Oshima, H., Aoki, M., Uchio, R., Naka, K., Nakamura, S., Hirao, A., Saya, H.,
Taketo, M.M., Oshima, M. Activated macrophages promote Wnt signalling through tumour
necrosis factor-alpha in gastric tumour cells. EMBO J. 2008, 27:1671-1681.
15. Maatouk, D.M., DiNapoli, L., Alvers, A., Parker, K.L., Taketo, M.M., Capel, B. Stabilization of
β-catenin in XY gonads causes male-to-female sex-reversal. Hum. Mol. Genet.
2008,
17:2949-2955.
16. Heiser, P.W., Cano, D.A., Landsman, L., Kim, G.E., Kench, J.G., Klimstra, D.S., Taketo, M.M.,
Biankin, A.V., Hebrok, M. Stabilization of β-catenin induces pancreas tumor formation.
Gastroenterology 2008, 135:1288-1300.
49
17. Fujishita, T., Aoki, K., Lane, H.A., Aoki, M., Taketo, M.M., Inhibition of the mTORC1
pathway suppresses intestinal polyp formation and reduces mortality in ApcΔ716 mice. Proc.
Natl. Acad. Sci. USA, 2008, 105:13544-13549.
18. Koso, H., Iida, A., Tabata, Y., Baba, Y., Satoh, S., Taketo, M.M., Watanabe, S.
CD138/syndecan-1 and SSEA-1 mark distinct populations of developing ciliary epithelium that
are regulated differentially by Wnt signal. Stem Cells 2008, 26:3162-3171.
19. Jeong, J.W., Lee, H.S., Franco, H.L., Broaddus, R.R., Taketo, M.M., Tsai, S.Y., Lydon, J.P.,
Demayo, F.J. β-Catenin mediates glandular formation and dysregulation of β-catenin induces
hyperplasia formation in the murine uterus. Oncogene 2008, 28:31-40.
20. Yu, W., McDonnell, K., Taketo, M.M., Bai, C.B. Wnt signaling determines ventral spinal cord
cell fates in a time-dependent manner. Devlopment 2008, 135:3687-3696.
21. Andreu, P., Peignon, G., Slomianny, C., Taketo, M.M., Colnot, S., Robine, S., Lamarque, D.,
Laurent-Puig, P., Perret, C., Romagnolo, B. A genetic study of the role of the Wnt/β-catenin
signalling in Paneth cell differentiation. Dev. Biol. 2008, 324:288-96.
22. Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C.J., Reis, M., Felici,
A., Wolburg, H., Fruttiger, M., Taketo, M.M., von Melchner, H., Plate, K.H., Gerhardt, H.,
Dejana, E. Wnt/β-catenin signaling controls development of the blood-brain barrier. J. Ce ll
Biol. 2008, 183:409-417.
23. Aoki, K., Taketo, M.M., Tissue-specific transgenic, conditional knockout and knock-in mice of
genes in the canonical Wnt signaling pathway. Methods Mol Biol. 2008, 468:307-331. Review.
24. Kato, T., Mizuno, S., Taketo, M. M., Kurosawa, T. M. The possible involvement of tensin2 in
the expression and extension of nephrin by glomerular podocytes in mice. Biomed Res. 2008,
29:279-87.
25. Kitamura, T., Biyajima, K., Aoki, M., Oshima, M., Taketo, M.M., Matrix metalloproteinase 7 is
required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient
intestinal adenocarcinomas. Lab Invest. 2009, 89:98-105.
26. Yu, X., Wang, Y., Jiang, M., Bierie, B., Roy-Burman. P., Shen, M. M., Taketo, M. M., Wills,
M., Matusik, R. J. Activation of β-Catenin in mouse prostate causes HGPIN and continuous
prostate growth after castration. Prostate. 2009, 69:249-62.
27. Suzuki, K., Yamaguchi, Y., Villacorte, M., Mihara, K., Akiyama, M., Shimizu, H., Taketo,
50
M.M., Nakagata, N., Tsukiyama, T., Yamaguchi, T. P., Birchmeier, W., Kato, S., Yamada, G.
Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling.
Development. 2009, 136:367-72.
28. Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo, M.M., McKay RD,
Awatramani RB. Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat
Neurosci. 2009, 12:125-31.
29. Taketo, M.M., Role of bone marrow-derived cells in colon cancer: lessons from mouse model
studies. J Gastroenterol. 2009, 44:93-102.
30. Zuklys S, Gill J, Keller MP, Hauri-Hohl M, Zhanybekova S, Balciunaite G, Na KJ, Jeker LT,
Hafen K, Tsukamoto N, Amagai T, Taketo, M.M., Krenger W, Holländer GA. Stabilized
β-catenin in thymic epithelial cells blocks thymus development and function. J Immunol. 2009,
182:2997-3007.
31. Taketo, M.M., Edelmann, W. Mouse models of colon cancer. Gastroenterology. 2009,
136:780-98. Review. (PMID: 19263594)
32. Kato, T., Kurosawa, T. M., Taketo, M.M., Proteinuria-induced chronic kidney disease in the
ICGN/Oa mice with a mutation of Tensin2 gene. Ren Fail. 2009, 31:229-38.
33. Oshima, H., Itadani, H., Kotani, H., Taketo, M.M., Oshima, M. Induction of prostaglandin E2
pathway promotes gastric hamartoma development with suppression of bone morphogenetic
protein signaling. Cancer Res. 2009, 69:2729-33.
34. Miyagawa, S., Satoh, Y., Haraguchi, R., Suzuki, K., Iguchi, T., Taketo, M. M., Nakagata, N.,
Matsumoto, T., Takeyama, K. I., Kato, S., Yamada, G. Genetic interactions of the Androgen
and Wnt/{beta}-catenin Pathways for the Masculinization of External Genitalia. Mol Endocrinol.
2009 Mar 12. [Epub ahead of print]
35. Arimura S, Matsunaga A, Kitamura T, Aoki K, Aoki M, Taketo MM. Reduced Level of
Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling.
Gastroenterology 137: 629-638, 2009. (PMID: 19427313)
.
36. Tanwar PS, Lee HJ, Zhang L, Zukerberg LR, Taketo MM, Rueda BR, Teixeira JM. Constitutive
Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of
Mesenchymal Tumors in Mice. Biol Reprod. 2009 Apr 29. [Epub ahead of print]
37. Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, van Es JH,
51
Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR. HDAC1 and HDAC2 regulate
oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci.
2009 Jul;12(7):829-38.
38. Martinez G, Wijesinghe M, Turner KN, Abud HE, Taketo MM, Noda T, Robinson ML, de
Iongh RU. Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt
signaling in lens differentiation. Invest Ophthalmol Vis Sci. 50(10): 4794-806 2009.
39. Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T,
Minamoto T, Kotani H, Taketo MM, Oshima M. Induction and downregulation of Sox17and its
possible roles during the course of gastrointestinal tumorigenesis. Gastroenterology. 2009 Jun
20. [Epub ahead of print]
40. Chang H, Guillou F, Taketo MM, Behringer RR. Overactive Beta-Catenin Signaling Causes
Testicular Sertoli Cell Tumor Development in the Mouse. Biol Reprod. 2009 Jun 24. [Epub
ahead of print]
41. Guo X, Mak KK, Taketo MM, Yang Y. The Wnt/beta-catenin pathway interacts differentially
with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One.
2009 Jun 26;4(6):e6067.
42. Shaham O, Smith AN, Robinson ML, Taketo MM, Lang RA, Ashery-Padan R. Pax6 is essential
for lens fiber cell differentiation. Development. 2009 Aug;136(15):2567-78.
43. Fujimura N, Taketo MM, Mori M, Korinek V, Kozmik Z. Spatial and temporal regulation of
Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev
Biol. 2009 Oct 1;334(1):31-45.
44. ○ Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T,
Minamoto T, Kotani H, Taketo MM, Oshima M. Induction and down-regulation of Sox17 and
its possible roles during the course of gastrointestinal tumorigenesis. Gastroenterology. 2009
Oct;137(4):1346-57.
45. Li C, Li A, Li M, Xing Y, Chen H, Hu L, Tiozzo C, Anderson S, Taketo MM, Minoo P.
Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and
bronchial polyposis. Dev Biol. 2009 Oct 1;334(1):97-108.
46. Miyoshi H, Deguchi A, Nakau M, Kojima Y, Mori A, Oshima M, Aoki M, Taketo MM.
Hepatocellular carcinoma development induced by conditional beta-catenin activation in
Lkb1+/- mice. Cancer Sci. 2009 Nov;100(11):2046-53. (PMID: 19671058)
52
47. Chang H, Guillou F, Taketo MM, Behringer RR. Overactive beta-catenin signaling causes
testicular sertoli cell tumor development in the mouse. Biol Reprod. 2009 Nov;81(5):842-9.
48. Guo X, Mak KK, Taketo MM, Yang Y. The Wnt/beta-catenin pathway interacts differentially
with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One.
2009 Jun 26;4(6):e6067.
49. Fujishita T, Aoki M, Taketo MM. The role of mTORC1 pathway in intestinal tumorigenesis.
Cell Cycle. 2009 Nov 15;8(22):3684-7.
50. Miyagawa S, Moon A, Haraguchi R, Inoue C, Harada M, Nakahara C, Suzuki K, Matsumaru D,
Kaneko T, Matsuo I, Yang L, Taketo MM, Iguchi T, Evans SM, Yamada G. Dosage-dependent
hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia
formation as an appendicular program. Development. 2009 Dec;136(23):3969-78.
51. Kakizaki, F., Aoki, K., Miyoshi, H. Carrasco, N., Aoki, M. and Taketo, M. M. CDX
Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in
the Colonic Epithelium. Gastroenterology 2010, 138:627-635. (PMID: 19900445)
52. Villacorte M, Suzuki K, Hayashi K, de Sousa Lopes SC, Haraguchi R, Taketo MM, Nakagata N,
Yamada G. Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical
Ectodermal Ridge (AER) regulates interdigit formation. Biochem Biophys Res Commun. 2010
Jan 22;391(4):1653-7.
53. Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, and Taketo MM (2010 Jun) LKB1
suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding
domain. J. Biol. Chem. 285: 18283-18290. (PMID: 20400510)
54. Tang M, Villaescusa JC, Luo SX, Guitarte C, Lei S, Miyamoto Y, Taketo MM, Arenas E,
Huang EJ. (2010 Jul) Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate
the neurogenesis of ventral midbrain dopamine neurons. J Neurosci. 30: 9280-91.
55. ○ Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, and
Taketo MM. (2010 Jul) Inactivation of CCR1 suppresses colon cancer liver metastasis by
blocking accumulation of immature myeloid cells in a mouse model. Proc. Natl. Acad. Sci.
USA 107: 13063-13068. (PMID: 20616008)
56. ○ Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A,
Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura K, Oshima M, and Taketo MM.
53
(2011 Jan) Suppression of colon cancer metastasis by Aes through inhibition of Notch
signaling. Cancer Cell 19: 125-137. (PMID: 21251616) (Featured Ar ticle: Fa culty of 100 0
paper)
57. Reid BS, Yang H, Melvin VS, Taketo MM, Williams T. (2011 Jan) Ectodermal Wnt/β-catenin
signaling shapes the mouse face. Dev Biol. 349: 261-9.
58. ○ Aoki, K., Kakizaki, F., Sakashita, H., Manabe, T., Aoki, M., and Taketo, M. M. (2011 Jan)
Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional
function that stabilizes p27Kip1. Cancer Res. 71: 593-602. (PMID: 21224344)
59. He F, Xiong W, Wang Y, Li L, Liu C, Yamagami T, Taketo MM, Zhou C, Chen Y. (2011 Feb)
Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3
expression. Dev Biol. 350: 511-9.
60. ○ Kawada K and Taketo MM. (2011 Feb) Significance and mechanism of lymph node
metastasis in cancer progression. Cancer Res. 71: 1214-1218. (PMID: 21212413)
61. Taketo, M. M. (2011 Mar) Reflections on the spread of metastasis to cancer prevention. Cancer
Prev. Res. 4: 324-328. (PMID: 21372032)
62. Ahmad I, Singh LB, Foth M, Morris CA, Taketo MM, Wu XR, Leung HY, Sansom OJ, Iwata T.
(2011 Mar) K-Ras and {beta}-catenin mutations cooperate with Fgfr3 mutations in mice to
promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech. 4: 548-55.
(PMID: 21504907)
63. Karalay O, Doberauer K, Vadodaria KC, Knobloch M, Berti L, Miquelajauregui A, Schwark M,
Jagasia R, Taketo MM, Tarabykin V, Lie DC, Jessberger S. (2011 Apr) Prospero-related
homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in
adult hippocampal neurogenesis. Proc Natl Acad Sci USA. 108: 5807-12. (PMID: 21436036)
64. Ouchi Y, Baba Y, Koso H, Taketo MM, Iwamoto T, Aburatani H, Watanabe S. (2011 Apr)
β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells.
Mol Cell Neurosci. 46: 770-80. (PMID: 21354309)
65. Fujishita, T., Aoki, M., and Taketo, M. M. (2011 May) JNK signaling promotes intestinal
tumorigenesis through mTOR complex1 activation in ApcΔ716 mice. Gatroenterology 140:
1556-1563 (Cover Article) (PMID: 21320501)
66. Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, Roberts DJ, Teixeira JM.
54
(2011 Jun) Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian
Endometrioid Adenocarcinomas with Dysregulated Wnt/β-Catenin and PTEN. PLoS One. 6:
e20715. (PMID: 21695255)
67. Sugai M, Aoki K, Osato M, Nambu Y, Ito K, Taketo MM, Shimizu A. (2011 Jun) Runx3 is
required for full activation of regulatory T cells to prevent colitis-associated tumor formation. J
Immunol. 186: 6515-20. (PMID: 21515792)
68. Rabbani P, Takeo M, Chou W, Myung P, Bosenberg M, Chin L, Taketo MM, Ito M. (2011 Jun)
Coordinated activation of wnt in epithelial and melanocyte stem cells initiates pigmented hair
regeneration. Cell 145(6):941-55. (PMID: 21663796)
69. Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY, Sansom OJ. (2011 Jul) Ras
mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2:
e124. (PMID: 21368895)
70. Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE,
Holzman LB, Susztak K. (2011 Jul) Wnt/{beta}-Catenin Pathway in Podocytes Integrates Cell
Adhesion, Differentiation, and Survival. J Biol Chem. 286: 26003-15. (PMID: 21613219)
71. Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay
B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP. (2011 Jul) From the
Cover: Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to
pituitary tumors in mice and humans. Proc Natl Acad Sci U S A. 108: 11482-7. (PMID:
21636786)
72. Koshimizu H, Fukui Y, Takao K, Ohira K, Tanda K, Nakanishi K, Toyama K, Oshima M,
Taketo MM, Miyakawa T. (2011 Dec). Adenomatous polyposis coli heterozygous knockout
mice display hypoactivity and age-dependent working memory deficits. Front Behav Neurosci.
(PMID: 22347851)
73. Jin YR, Han XH, Taketo MM, Yoon JK. (2012 Mar). Wnt9b-dependent FGF signaling is
crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip
development. Development [e-pub ahead of print] (PMID: 22461561)
74. Beyer C, Schramm A, Akhmetshina A, Dees C, Kireva T, Gelse K, Sonnylal S, de
Crombrugghe B, Taketo MM, Distler O, Schett G, Distler JH. (2012 May) β-catenin is a central
mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis. 71: 761-767.
(PMID: 22328737)
55
75. Chassot AA, Gregoire EP, Lavery R, Taketo MM, de Rooij DG, Adams IR, Chaboissier MC.
(2011 Oct) RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into
meiosis in the mouse fetal ovary. PLoS One 6: e25641. (PMID: 21991325)
76. Kawada K, Hasegawa S, Murakami T, Itatani Y, Hosogi H, Sonoshita M, Kitamura T, Fujishita
T, Iwamoto M, Matsumoto T, Matsusue R, Hida K, Akiyama G, Okoshi K, Yamada M,
Kawamura J, Taketo MM, Sakai Y. (2011 Oct) Molecular mechanisms of liver metastasis. Int J
Clin Oncol. 16: 464-72. (PMID: 21847533)
77. Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S,
Iwama A, Nakauchi H. (2011 Nov) Nonmyelinating Schwann cells maintain hematopoietic
stem cell hibernation in the bone marrow niche. Cell 147: 1146-58. (PMID: 2218468)
78. Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE,
Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. (2011 Dec) β-catenin
signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell 20:
741-54. (doi: 10.1016/j.ccr.2011.10.030)
79. Joksimovic M, Patel M, Taketo MM, Johnson R, Awatramani R. (2012 Jan). Ectopic
Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plate.
PLoS One 7: e30266. (PMID: 22276170)
80. Taketo MM. (2012 Apr) Roles of stromal microenvironment in colon cancer progression. J
Biolchem. [E-pub ahead of print] (PMID: 22496483)
81. Beyer, C., A. Schramm, Akhmetshina, A., Dees, C., Kierva, T., Gelse, K., Sonnylal, S., de
Crombrugghe, B., Taketo, M. M., Distler, O., Schett, G., Distler, J. H. W. (2012). "β-catenin is
a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis." Ann. Reum. Dis.
82. Bluske, K. K., T. Y. Vue, Kawakami, Y., Taketo, M. M., Yoshikawa, K., Johnson, J. E.,
Nakagawa, Y. (2012). "β-Catenin signaling specifies progenitor cell identity in parallel with
Shh signaling in the developing mammalian thalamus." Development 139: 2692-2702.
83. Hari, L., I. Miescher, Shakhova, O., Suter, U., Chin, L., Taketo, M., Richardson, W. D.,
Kessaris, N., Sommer, L. (2012). "Temporal control of neural crest lineage generation by
Wnt/β-catenin signaling." Development 139: 2107-2117.
84. Jin, Y.-R., X. H. Han, Taketo, M. M., Yoon, J. K. (2012). "Wnt9b-dependent FGF signaling is
crucial for outgrowth of the nasal and maximally processes during upper jaw and lip
development." Development 139: 1821-1830.
56
85. Maezawa, Y., M. Binnie, Li, C., Thorner, P., Hui, C.-C., Alman, B., Taketo, M. M., Quaggin, S.
E. (2012). "A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme."
PLoSone 7(7): e40547.
86. Pei, Y., S. N. Brun, Markant, S. L., Lento, W., Gibson, P., Taketo, M. M. Giovannini, M.,
Gilbertson, R. J., Wechsler-Reya, R. J. (2012). "WNT signaling increases proliferation and
impairs differentiation of stem cells in the devloping crebellum." Development 139:
1724-1733.
9) Michiyuki Matsuda
1. Aoki K, Kiyokawa E, Nakamura T, Matsuda M (2008) Visualization of growth signal
transduction cascades in living cells with genetically encoded probes based on Forster
resonance energy transfer. Philos Trans R Soc Lond B Biol Sci 363: 2143-2151
2.
Aoki K, Komatsu N, Hirata E, Kamioka Y, Matsuda M (2011a) Stable expression of FRET
biosensors: a new light in cancer research. Cancer Sci 103: 614-619
3.
Aoki K, Matsuda M (2009) Visualization of small GTPase activity with fluorescence resonance
energy transfer-based biosensors. Nature Protocol 4: 1623-1631
4.
Aoki K, Yamada M, Kunida K, Yasuda S, Matsuda M (2011b) Processive phosphorylation of
ERK MAP kinase in mammalian cells. Proc Natl Acad Sci U S A 108: 12675-12680
5.
Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M (2009) Suppression
of RhoG activity is mediated by a syndecan 4.synectin.RhoGDI1 complex and is reversed by
PKCalpha in a Rac1 activation pathway. J Cell Biol 186: 75-83
6.
Goto A, Hoshino M, Matsuda M, Nakamura T (2011) Phosphorylation of STEF/Tiam2 by
protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl
cAMP-treated PC12D cells. Mol Biol Cell 22: 1780-1790
7.
Hara S, Kiyokawa E, Iemura SI, Natsume T, Wassmer T, Cullen PJ, Hiai H, Matsuda M (2008)
The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose
6-phosphate receptor transport. Mol Biol Cell 19: 3823-3835
8.
Higashi M, Ishikawa C, Yu J, Toyoda A, Kawana H, Kurokawa K, Matsuda M, Kitagawa M,
Harigaya K (2009) Human Mena associates with Rac1 small GTPase in glioblastoma cell lines.
PLoS One 4: e4765
57
9.
○ Hirata E, Arakawa Y, Shirahata M, Yamaguchi M, Kishi Y, Okada T, Takahashi JA,
Matsuda M, Hashimoto N (2009) Endogenous tenascin-C enhances glioblastoma invasion with
reactive change of surrounding brain tissue. Cancer Sci 100: 1451-1459
10. ○ Hirata E, Yukinaga H, Kamioka Y, Arakawa Y, Miyamoto S, Okada T, Sahai E, Matsuda
M (2012) In vivo fluorescence resonance energy transfer imaging reveals differential activation
of Rho-family GTPases in glioblastoma cell invasion J Cell Sci 125: 858-868
11. Itoh RE, Kiyokawa E, Aoki K, Nishioka T, Akiyama T, Matsuda M (2008) Phosphorylation
and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF. J Cell Sci
121: 2635-2642
12. ○ Kamioka Y, Sumiyama K, Mizuno R, Sakai Y, Hirata E, Kiyokawa E, Matsuda M (2012)
Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell
Struct Funct 37: 65-73
13. Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M (2010) Multiple decisive phosphorylation
sites for the negative feedback regulation of SOS1 via ERK. J Biol Chem 285: 33540-33548
14. Kitano M, Nakaya M, Nakamura T, Nagata S, Matsuda M (2008) Imaging of Rab5 activity
identifies essential regulators for phagosome maturation. Nature (London) 453: 241-245
15. Kiyokawa E, Aoki K, Nakamura T, Matsuda M (2010) Spatiotemporal regulation of small
GTPases as revealed by probes based on the principle of Foerster resonance energy transfer
(FRET): Implications for signaling and pharmacology. Annu Rev Pharmacol Toxicol 51:
337-358
16. Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M (2011)
Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol
Biol Cell 22: 4647-4656
17. Kumagai Y, Kamioka Y, Yagi S, Matsuda M, Kiyokawa E (2011) A genetically encoded
Forster resonance energy transfer biosensor for two-photon excitation microscopy. Anal
Biochem 413: 192-199
18. Kunida K, Matsuda M, Aoki K (2012) FRET imaging and statistical signal processing reveal
positive and negative feedback loops regulating the morphology of randomly migrating
HT-1080 cells. J Cell Sci 125: 2381-2392
58
19. Lu A, Tebar F, Alvarez-Moya B, Lopez-Alcala C, Calvo M, Enrich C, Agell N, Nakamura T,
Matsuda M, Bachs O (2009) A clathrin-dependent pathway leads to KRas signaling on late
endosomes en route to lysosomes. J Cell Biol 184: 863-879
20. Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki
K, Matsuda M (2010) The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and
Raf. J Biol Chem 285: 7818-7826
21. Mitsushima M, Aoki K, Ebisuya M, Matsumura S, Yamamoto T, Matsuda M, Toyoshima F,
Nishida E (2010) Revolving movement of a dynamic cluster of actin filaments during mitosis. J
Cell Biol 191: 453-462
22. Nakamura T, Aoki K, Matsuda M (2008) FRET imaging and in silico simulation: analysis of
the signaling network of nerve growth factor-induced neuritogenesis. Brain Cell Biol 36: 19-30
23. Nakamura T, Matsuda M (2009) In vivo imaging of signal transduction cascades with probes
based on Forster Resonance Energy Transfer (FRET). Curr Protoc Cell Biolo Chapter 14: Unit
14.10
24. Nakaya M, Kitano M, Matsuda M, Nagata S (2008) Spatiotemporal regulation of Rac1 for
engulfment of apoptotic cellsA1 - Nakaya,M. Proc Natl Acad Sci U S A 105: 9198-9203
25. Nishioka T, Aoki K, Hikake K, Yoshizaki H, Kiyokawa E, Matsuda M (2008) Rapid turnover
rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell 19: 4213-4223
26. Nishioka T, Frohman MA, Matsuda M, Kiyokawa E (2010) Heterogeneity of phosphatidic acid
levels and distribution at the plasma membrane in living cells as visualized by a Foerster
resonance energy transfer (FRET) biosensor. J Biol Chem 285: 35979-35987
27. Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y,
Kawai J, Suzuki M, Hayashizaki Y, Hiai H (2008) Mutation of Dock5, a member of the
guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp Eye
Res 86: 828-834
28. Parrini MC, Camonis J, Matsuda M, de Gunzburg J (2009) Dissecting activation of the PAK1
kinase at protrusions in living cells 2. J Biol Chem 284: 24133-24143
29. Parrini MC, Sadou-Dubourgnoux A, Aoki K, Kunida K, Biondini M, Hatzoglou A, Poullet P,
Formstecher E, Yeaman C, Matsuda M, Rosse C, Camonis J (2011) SH3BP1, an
exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell 42:
59
650-661
30. ○ Tachibana M, Kiyokawa E, Hara S, Iemura SI, Natsume T, Manabe T, Matsuda M (2009)
Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell
migration by regulating focal adhesion formation. Exp Cell Res 315: 863-876
31. Tsukada Y, Aoki K, Nakamura T, Sakumura Y, Matsuda M, Ishii S (2008) Quantification of
local morphodynamics and local GTPase activity by edge evolution tracking. PLoS Comput
Biol 4: e1000223
32. Tunceroglu A, Matsuda M, Birge RB (2010) Real-time fluorescent resonance energy transfer
analysis to monitor drug resistance in chronic myelogenous leukemia. Mol Cancer Ther 9:
3065-3073
10) Shunichi Takeda
2012
1. Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck
D, Caldecott KW, El-Khamisy SF (2012) TDP2 promotes repair of topoisomerase I-mediated
DNA damage in the absence of TDP1. Nucleic Acids Res (in press)
2.
Morita A, Nakahira K, Hasegawa T, Uchida K, Taniguchi Y, Takeda S, Toyoda A, Sakaki Y,
Shimada A, Takeda H, Yanagihara I (2012) Establishment and characterization of Roberts
syndrome and SC phocomelia model medaka (Oryzias latipes). Develop Growth Differ 54(5):
588-604
3.
Kohzaki M, Chiourea M, Versini G, Adachi N, Takeda S, Gagos S, Halazonetis TD (2012) The
helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA
templates damaged by ionizing radiation. Carcinogenetis 33(6): 1203-1210
4.
Liu X, Lee J， Ji K, Takeda S, Choi K (2012) Potentials and mechanisms of genotoxicity of six
pharmaceuticals frequently detected in freshwater environment. Toxicol Let 211(1): 70-76
5.
Murai J, Huang SY, Das BB, Dexheimer TS, Takeda S, Pommier Y (2012) Tyrosyl-DNA
phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II, and
base alkylation in vertebrate cells. J Biol Chem 287(16): 12848-12857
6.
Moldovan GL, Dejsuphong D, Petalcorin MI, Hofmann K, Takeda S, Boulton SJ, D'Andrea
AD (2012) Inhibition of homologous recombination by the PCNA-interacting protein PARI.
Mol Cell 45(1): 75-86
60
2011
7. Hégarat N, Smith E, Nayak G, Takeda S, Eyers PA, Hochegger H (2011) Aurora A and Aurora
B jointly coordinate chromosome segregation and anaphase microtubule dynamics. J Cell Biol
195(7): 1103-1113
8.
Ishikawa T, Taniguchi Y, Okada T, Takeda S, Mori K (2011) Vertebrate unfolded protein
response: Mammalian signaling pathways are conserved in medaka fish. Cell Struct Funct
36(2): 247-259
9.
Chisada S, Okamoto H, Taniguchi Y, Kimori Y, Toyoda A, Sakaki Y, Takeda S, Yoshiura Y
(2011) Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and
hypertrophy, which occur sequentially during post-hatch development. Dev Biol 359(1): 82-94
10. Yang K, Moldovan GL, Vinciguerra P, Murai J, Takeda S, D'Andrea AD (2011) Regulation of
the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev 25(17): 1847-1858
11. Ninagawa S, Okada T, Takeda S, Mori K (2011) SEL1L Is Required for Endoplasmic
Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane
Proteins in Chicken DT40 Cell Line. Cell Struct Funct 36(2): 187-195
12. Ji K, Seo J, Liu X, Lee J, Lee S, Lee W, Park J, Khim JS, Hong S, Choi Y, Shim WJ, Takeda S,
Giesy JP, Choi K (2011) Genotoxicity and endocrine disruption potentials of sediment near an
oil spill site: 2 years after the Hebei Spirit oil spill. Environ Sci Technol 45(17): 7481-7488
13. Qing Y, Yamazoe M, Hirota K, Dejsuphong D, Sakai W, Yamamoto KN, Bishop DK, Wu X,
Takeda S (2011) The epistatic relationship between BRCA2 and the other RAD51 mediators in
homologous recombination. PLoS Genet 7(7): e1002148
14. Abe T, Sugimura K, Hosono Y, Takami Y, Akita M, Yoshimura A, Tada S, Nakayama T,
Murofushi H, Okumura K, Takeda S, Horikoshi M, Seki M, Enomoto T (2011) The histone
chaperone FACT maintains normal replication fork rates. J Biol Chem 286(35): 30504-30512
15. Takaku M, Tsujita T, Horikoshi N, Takizawa Y, Qing Y, Hirota K, Ikura M, Ikura T, Takeda S,
Kurumizaka H (2011) Purification of the human SMN-GEMIN2 complex and assessment of its
stimulation of RAD51-mediated DNA recombination reactions. Biochemistry 50(32):
6797-6805
16. Ji K, Choi K, Giesy JP, Musarrat J, Takeda S (2011) Genotoxicity of Several Polybrominated
Diphenyl Ethers (PBDEs) and Hydroxylated PBDEs, and Their Mechanisms of Toxicity.
61
Environ Sci Technol 45(11): 5003-5008
17. Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt
KL, Tice RR (2011) Characterization of environmental chemicals with potential for DNA
damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen
52(7): 547-561
18. Murai J, Yang K, Dejsuphong D, Hirota K, Takeda S, D'Andrea AD (2011) The USP1/UAF1
Complex Promotes Double Strand Break Repair through Homologous Recombination. Mol
Cell Biol 31(12): 2462-2469
19. Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda
S, Hirota K (2011) Involvement of SLX4 in interstrand cross-link repair is regulated by the
Fanconi anemia pathway. Proc Natl Acad Sci USA 108(16): 6492-6496
20. Quennet V, Beucher A, Barton O, Takeda S, Löbrich M (2011) CtIP and MRN promote
non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic
Acids Res 39(6): 2144-2452
21. Ridpath JR, Takeda S, Swenberg JA, Nakamura J (2011) Convenient, multi-well plate-based
DNA damage response analysis using DT40 mutants is applicable to a High-throughput
genotoxicity assay with characterization of modes of action (p NA). Environ Mol Mutagen
52(2): 153-160
2010
22. ○ Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R (2010) Ammonium chloride and
tunicamycin are novel toxins for dopaminergic neurons and induced Parkinson’s disease-like
phenotypes in medaka fish. J Neurochem 115(5): 1150-1160
23. Yoshikiyo K, Kratz K, Hirota K, Nishihara K, Takata M, Kurumizaka H, Horimoto S, Takeda
S, Jiricny J (2010) KIAA1018/FAN1 nuclease protects cells against genomic instability
induced by interstrand cross-linking agents. Proc Natl Acad Sci USA 107(50): 21553-21557
24. Narita T, Tsurimoto T, Yamamoto J, Nishihara K, Ogawa K, Ohashi E, Evans T, Iwai S,
Takeda S, Hirota K (2010) Human replicative DNA polymerase δ can bypass T-T (6-4)
ultraviolet photoproducts on template strands. Genes Cells .15(12): 1228-1239
25. Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ,
Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S,
Lavin MF, Heierhorst J (2010) Dual Functions of ASCIZ in the DNA Base Damage Response
62
and Pulmonary Organogenesis. PLoS Genet 6(10): e1001170
26. Iijima J, Zeng Z, Takeda S, Taniguchi Y (2010) RAP80 acts independently of BRCA1 in repair
of topoisomerase II poison-induced DNA damage. Cancer Res 70(21): 8467-8474
27. Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szuts D, Iwai S, Sale JE,
Lehmann A, Takeda S (2010) Simultaneous disruption of two DNA polymerases, Polη and
Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.
PLoS Genet 6(10): e1001151
28. Luke AM, Chastain PD, Pachkowski BF, Afonin V, Takeda S, Kaufman DG, Swenberg JA,
Nakamura J (2010) Accumulation of true single strand breaks and AP sites in base excision
repair deficient cells. Mutat Res 694(1-2): 65-71
29. Paddock MN, Buelow BD, Takeda S, Scharenberg AM (2010) The BRCT domain of PARP-1
is required for immunoglobulin gene conversion. PLoS Biol 8(7): e1000428
30. ○ Matsui H, Ito H, Taniguchi Y, Inoue H, Takeda S, Takahashi R (2010) Proteasome
inhibition in medaka brain induces the features of Parkinson disease. J Neurochem . 115(1):
178-187
31. Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M,
Halazonetis T, Takeda S (2010) DNA polymerases ν and θ are required for efficient
Immunoglobulin V gene diversification in chicken. J Cell Biol 189(7): 1117-1127
32. Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K,
Takahashi M, Shibata T, Kurumizaka H, Takeda S (2010) GEMIN2 promotes accumulation of
RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res 38(15):
5059-5074
33. Hara K, Hashimoto H, Murakumo Y, Kobayashi S, Kogame T, Unzai S, Akashi S, Takeda S,
Shimizu T, Sato M (2010) Crystal structure of human REV7 in complex with a human REV3
fragment and structural implication of the interaction between DNA polymerase zeta and
REV1. J Biol Chem 285(16): 12299-12307
34. Hashimoto H, Takami Y, Sonoda E, Iwasaki T, Iwano H, Tachibana M, Takeda S, Nakayama
T, Kimura H, Shinkai Y (2010) Histone H1 null vertebrate cells exhibit altered nucleosome
architecture. Nucleic Acids Res 38(11): 3533-3545
35. Wang H, Zhang X, Wang P, Yu X, Essers J, Chen D, Kanaar R, Takeda S, Wang Y (2010)
63
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear
energy transfer radiation. Nucleic Acids Res 38(10): 3245-3251
36. Asagoshi K, Tano K, Chastain II PD, Adachi N, Sonoda E, Kikuchi K, Koyama H, Nagata K,
Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J (2010) FEN1
functions in long patch base excision repair under conditions of oxidative stress in vertebrate
cells. Mol Cancer Res 8(2): 204-215
37. Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y,
Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y (2010) Collaborative
action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to
facilitate subsequent break repair. PLoS Genet 6(1): e1000828
38. Wang X, Takenaka K, Takeda S (2010) PTIP promotes DNA double-strand break repair
through homologous recombination. Genes Cells 15(3): 243-254
39. ○ Matsui H, Taniguchi Y, Inoue H, Kobayashi Y, Sakaki Y, Toyoda A, Uemura K,
Kobayashi D, Takeda S, Takahashi R (2010) Loss of PINK1 in medaka fish (Oryzias latipes)
causes late-onset decrease in spontaneous movement. Neurosci Res 66(2): 151-161
40. Bourke E, Brown JA, Takeda S, Hochegger H, Morrison CG (2010) DNA damage induces
Chk1-dependent threonine-160 phosphorylation and activation of Cdk2. Oncogene 29(4):
616-624
Review
41. Evans TJ, Yamamoto KN, Hirota K, Takeda S (2010) Mutant cells defective in DNA repair
pathways provide a sensitive high-throughput assay for genotoxicity. DNA Repair (Amst )
9(12): 1292-1298
2009
42. Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S (2009) A novel approach
using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the
genotoxicity of environmental contaminants. Environ Health Perspect 117(11): 1737-1744
43. Pachkowski BF, Tano K, Afonin V, Elder RH, Takeda S, Watanabe M, Swenberg JA,
Nakamura J (2009) Cells deficient in PARP-1 show an accelerated accumulation of DNA
single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS.
Mutat Res 671(1-2): 93-99
44. Kawasaki T, Saito K, Mitsui K, Ikawa M, Yamashita M, Taniguchi Y, Takeda S, Mitani K,
64
Sakai N (2009) Introduction of a foreign gene into zebrafish and medaka cells using adenoviral
vectors. Zebrafish 6(3): 253-258
45. ○ Matsui H, Taniguchi Y, Inoue H, Uemura K, Takeda S, Takahashi R (2009) A chemical
neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and
persistent loss of dopamine neurons in medaka fish. Neurosci Res 65(3): 263-271
46. Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K (2009) Bloom DNA
helicase facilitates homologous recombination between diverged homologous sequences. J Biol
Chem 284(39): 26360-26367
47. Suzuki J, Yamaguchi K, Kajikawa M, Ichiyanagi K, Adachi N, Koyama H, Takeda S, Okada N
(2009) Genetic evidence that the non-homologous end-joining repair pathway is involved in
LINE retrotransposition. PLoS Genet 5(4): e1000461
48. Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V
(2009) An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting
CEP63. Nat Cell Biol 11(3): 278-285
49. Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura
K, Sumitomo Y, Bree RT, Lowndes NF, Takeda S (2009) Genetic evidence for single-strand
lesions initiating Nbs1-dependent homologous recombination in diversification of Ig V in
chicken B lymphocytes. PLoS Genet 5(1): e1000356
50. Kong X, Ball AR, Jr., Sonoda E, Feng J, Takeda S, Fukagawa T, Yen TJ, Yokomori K (2009)
Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle
assembly in vertebrate cells. Mol Biol Cell 20(5): 1289-1301
Review
51. Motegi A, Murakawa Y, Takeda S (2009) The vital link between the ubiquitin-proteasome
pathway and DNA repair: Impact on cancer therapy. Cancer Lett 283(1): 1-9
2008
52. Sugimura K, Takebayashi S, Taguchi H, Takeda S, Okumura K (2008) PARP-1 ensures the
modulation of replication fork progression by homologous recombination on damaged DNA. J
Cell Biol 183(7): 1203-1212
53. Abe T, Ishiai M, Hosono Y, Yoshimura A, Tada S, Adachi N, Koyama H, Takata M, Takeda S,
Enomoto T, Seki M (2008) KU70/80, DNA-PKcs, and Artemis are essential for the rapid
induction of apoptosis after massive DSB formation. Cell Signal 20(11): 1978-1985
65
54. Saberi A, Nakahara M, Sale JE, Kikuchi K, Arakawa H, Buerstedde J-M, Takeda S, Sonoda E
(2008) The 9-1-1 DNA clamp is required for immunoglobulin gene conversion. Mol Cell Bio l
28(19)：6113-6122
55. Richard D, Bolderson E, Cubeddu L, Wadsworth RIM, Savage K, Sharma GG, Nicolette ML,
Tsvetanov S, McIlwraith MJ, Pandita R, Takeda S, Hay TT, Gautier J, West SC, Paull TT,
Pandita TK, White MF, Khanna KK (2008) Single stranded DNA binding protein hSSB1 is
critical for genomic stability. Nature 453(7195): 677-681
56. Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobayashi M, Yamamoto K,
Heierhorst J, Takeda S, Taniguchi Y (2008) DNA damage response protein ASCIZ links base
excision repair with immunoglobulin gene conversion. Biochem Biophys Res Commun 371(2):
225-229
57. Faure V, Wenner T, Cooley C, Bourke E, Farr CJ, Takeda S, Morrison CG (2008) Ku70 prevents
genome instability resulting from heterozygosity of the telomerase RNA component in a
vertebrate tumour line. DNA Repair (Amst) 7(5): 713-724
Review
58. Hochegger H, Takeda S, Hunt T (2008) Cyclin-dependent kinases and cell-cycle transitions:
does one fit all? Nat Rev Mol Cell Biol 9(11)：910-916
11) Masahiro Hiraoka
1.
Harada H, Xie X, Itasaka S, Zeng L, Zhu Y, Morinibu A, Shinomiya K, Hiraoka M (2008)
Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid
tumors. Biochemical and biophysical research communications 373: 533-538
2.
Nakamura K, Mizowaki T, Imada H, Karasawa K, Uno T, Onishi H, Nihei K, Sasaki S, Ogura
M, Akimoto T (2008) External-beam radiotherapy for localized or locally advanced prostate
cancer in Japan: a multi-institutional outcome analysis. Jpn J Clin Oncol 38: 200-204
3.
○ Nakamura M, Narita Y, Matsuo Y, Narabayashi M, Nakata M, Yano S, Miyabe Y, Matsugi
K, Sawada A, Norihisa Y, Mizowaki T, Nagata Y, Hiraoka M (2008) Geometrical differences
in target volumes between slow CT and 4D CT imaging in stereotactic body radiotherapy for
lung tumors in the upper and middle lobe. Med Phys 35: 4142-4148
4.
○ Nakayama H, Mizowaki T, Narita Y, Kawada N, Takahashi K, Mihara K, Hiraoka M
(2008) Development of a three-dimensionally movable phantom system for dosimetric
66
verifications. Med Phys 35: 1643-1650
5.
Norihisa Y, Nagata Y, Takayama K, Matsuo Y, Sakamoto T, Sakamoto M, Mizowaki T, Yano
S, Hiraoka M (2008) Stereotactic body radiotherapy for oligometastatic lung tumors. Int J
Radiat Oncol Biol Phys 72: 398-403
6.
Tanabe K, Hirata N, Harada H, Hiraoka M, Nishimoto S (2008) Emission under hypoxia:
one-electron reduction and fluorescence characteristics of an indolequinone-coumarin
conjugate. Chembiochem 9: 426-432
7.
Zeng L, Ou G, Itasaka S, Harada H, Xie X, Shibuya K, Kizaka-Kondoh S, Morinibu A,
Shinomiya K, Hiraoka M (2008) TS-1 enhances the effect of radiotherapy by suppressing
radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis.
Cancer science 99: 2327-2335
8.
Zhu SY, Mizowaki T, Norihisa Y, Takayama K, Nagata Y, Hiraoka M (2008) Comparisons of
the impact of systematic uncertainties in patient setup and prostate motion on doses to the
target among different plans for definitive external-beam radiotherapy for prostate cancer. Int J
Clin Oncol 13: 54-61
9.
○ Isomura M, Oya N, Tachiiri S, Kaneyasu Y, Nishimura Y, Akimoto T, Hareyama M, Sugita
T, Mitsuhashi N, Yamashita T, Aoki M, Sai H, Hirokawa Y, Sakata K, Karasawa K, Tomida A,
Tsuruo T, Miki Y, Noda T, Hiraoka M (2008) IL12RB2 and ABCA1 genes are associated with
susceptibility to radiation dermatitis. Clin Cancer Res 14: 6683-6689
10. Kawashita M, Domi S, Saito Y, Aoki M, Ebisawa Y, Kokubo T, Saito T, Takano M, Araki N,
Hiraoka M (2008) In vitro heat generation by ferrimagnetic maghemite microspheres for
hyperthermic treatment of cancer under an alternating magnetic field. J Mater Sci Mater Med
19: 1897-1903
11. Kosaka Y, Mitsumori M, Yamauchi C, Narita Y, Hiraoka M (2008) Feasibility of accelerated
partial breast irradiation using three-dimensional conformal radiation therapy for Japanese
women: a theoretical plan using six patients' CT data. Breast Cancer 15: 108-114
12. Mitsumori M, Hiraoka M (2008) Current status of accelerated partial breast irradiation. Breast
Cancer 15: 101-107
13. Naka K, Narita A, Tanaka H, Chujo Y, Morita M, Inubushi T, Nishimura I, Hiruta J,
Shibayama H, Koga M, Ishibashi S, Seki J, Kizaka-Kondoh S, Hiraoka M (2008) Biomedical
applications of imidazolium cation-modified iron oxide nanoparticles. Polymers for Advanced
67
Technologies 19: 1421-1429
14. Nakamura K, Kodaira T, Shikama N, Kagami Y, Ishikura S, Shibata T, Hiraoka M (2008a)
Accelerated fractionation versus conventional fractionation radiation therapy for glottic cancer
of T1-2N0M0 Phase III study: Japan Clinical Oncology Group study (JCOG 0701). Jpn J Clin
Oncol 38: 387-389
15. Tanisaka H, Kizaka-Kondoh S, Makino A, Tanaka S, Hiraoka M, Kimura S (2008)
Near-infrared fluorescent labeled peptosome for application to cancer imaging. Bioconjug
Chem 19: 109-117
16. Yamada K, Akiyama N, Yamada S, Tanaka H, Saito S, Hiraoka M, Kizaka-Kondoh S (2008)
Taip2 is a novel cell death-related gene expressed in the brain during development. Biochem
Biophys Res Commun 369: 426-431
17. Harada H, Hiraoka M (2009) Protein Transduction Domain-mediated Delivery of Anti-cancer
Drugs and Proteins. In Pharmaceutical Perspectives of Cancer Therapeutics, Lu Y, Mahato RI
(eds), pp 297-319. Springer
18. Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M
(2009) The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and
reoxygenation-dependent manner in irradiated tumors. The Journal of biological chemistry 284:
5332-5342
19. Harada H, Itasaka S, Zhu Y, Zeng L, Xie X, Morinibu A, Shinomiya K, Hiraoka M (2009)
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of
radiation therapy. British journal of cancer 100: 747-757
20. Hirata N, Fujisawa Y, Tanabe K, Harada H, Hiraoka M, Nishimoto S (2009) Radiolytic
activation of a cytarabine prodrug possessing a 2-oxoalkyl group: one-electron reduction and
cytotoxicity characteristics. Org Biomol Chem 7: 651-654
21. Itasaka S, Hiraoka M (2009) Treatment of the Primary Tumor in Metastatic Cancer: Influence
on Outcome. In The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary
Strategies, Molls M, Vaupel P, Nieder C, Anscher MS (eds), 21, pp 347-354. Springer
22. Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y, Shibuya K, Hirota K,
Semenza GL, Hiraoka M (2009) Selective killing of hypoxia-inducible factor-1-active cells
improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clinical
cancer research : an official journal of the American Association for Cancer Research 15:
68
3433-3441
23. Kizaka-Kondoh S, Tanaka S, Harada H, Hiraoka M (2009) The HIF-1-active
microenvironment: an environmental target for cancer therapy. Adv Drug Deliv Rev 61:
623-632
24. ○ Matsugi K, Narita Y, Sawada A, Nakamura M, Miyabe Y, Matsuo Y, Narabayashi M,
Norihisa Y, Mizowaki T, Hiraoka M (2009) Measurement of interfraction variations in position
and size of target volumes in stereotactic body radiotherapy for lung cancer. Int J Radiat Oncol
Biol Phys 75: 543-548
25. Miki K, Kuramochi Y, Oride K, Inoue S, Harada H, Hiraoka M, Ohe K (2009) Ring-opening
metathesis polymerization-based synthesis of ICG-containing amphiphilic triblock copolymers
for in vivo tumor imaging. Bioconjug Chem 20: 511-517
26. ○ Miyabe Y, Narita Y, Mizowaki T, Matsuo Y, Takayama K, Takahashi K, Kaneko S,
Kawada N, Maruhashi A, Hiraoka M (2009) New algorithm to simulate organ movement and
deformation for four-dimensional dose calculation based on a three-dimensional CT and
fluoroscopy of the thorax. Med Phys 36: 4328-4339
27. ○ Mukumoto N, Tsujii K, Saito S, Yasunaga M, Takegawa H, Yamamoto T, Numasaki H,
Teshima T (2009) A preliminary study of in-house Monte Carlo simulations: an integrated
Monte Carlo verification system. Int J Radiat Oncol Biol Phys 75: 571-579
28. Nagata Y, Hiraoka M, Mizowaki T, Narita Y, Matsuo Y, Norihisa Y, Onishi H, Shirato H
(2009) Survey of stereotactic body radiation therapy in Japan by the Japan 3-D Conformal
External Beam Radiotherapy Group. Int J Radiat Oncol Biol Phys 75: 343-347
29. Nakamura K, Ogawa K, Sasaki T, Onishi H, Koizumi M, Araya M, Mukumoto N, Mitsumori
M, Teshima T, Japanese Patterns of Care Study Working Subgroup of Prostate C (2009)
Patterns of radiation treatment planning for localized prostate cancer in Japan: 2003-05 patterns
of care study report. Jpn J Clin Oncol 39: 820-824
30. ○ Nakamura M, Narita Y, Matsuo Y, Narabayashi M, Nakata M, Sawada A, Mizowaki T,
Nagata Y, Hiraoka M (2009) Effect of audio coaching on correlation of abdominal
displacement with lung tumor motion. Int J Radiat Oncol Biol Phys 75: 558-563
31. ○ Nakamura M, Narita Y, Sawada A, Matsugi K, Nakata M, Matsuo Y, Mizowaki T, Hiraoka
M (2009) Impact of motion velocity on four-dimensional target volumes: a phantom study.
Med Phys 36: 1610-1617
69
32. Ogawa K, Nakamura K, Sasaki T, Onishi H, Koizumi M, Araya M, Mukumoto N, Mitsumori
M, Teshima T, Japanese Patterns of Care Study Working Subgroup of Prostate C (2009)
Postoperative radiotherapy for localized prostate cancer: clinical significance of nadir
prostate-specific antigen value within 12 months. Anticancer Res 29: 4605-4613
33. Ogawa K, Nakamura K, Sasaki T, Onishi H, Koizumi M, Shioyama Y, Araya M, Mukumoto N,
Mitsumori M, Teshima T, Japanese Patterns of Care Study Working Subgroup of Prostate C
(2009) External beam radiotherapy for clinically localized hormone-refractory prostate cancer:
clinical significance of Nadir prostate-specific antigen value within 12 months. Int J Radiat
Oncol Biol Phys 74: 759-765
34. Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M (2009) Usefulness of HIF-1
imaging for determining optimal timing of combining bevacizumab and radiotherapy. Int J
Radiat Oncol Biol Phys 75: 463-467
35. ○ Takayama K, Mizowaki T, Kokubo M, Kawada N, Nakayama H, Narita Y, Nagano K,
Kamino Y, Hiraoka M (2009) Initial validations for pursuing irradiation using a gimbals
tracking system. Radiother Oncol 93(1):45-49
36. Tanabe K, Harada H, Narazaki M, Tanaka K, Inafuku K, Komatsu H, Ito T, Yamada H, Chujo
Y, Matsuda T, Hiraoka M, Nishimoto S (2009) Monitoring of biological one-electron reduction
by (19)F NMR using hypoxia selective activation of an (19)F-labeled indolequinone derivative.
J Am Chem Soc 131: 15982-15983
37. Wakamatsu T, Tanaka T, Oda S, Nishi K, Harada H, Daijo H, Takabuchi S, Kai S, Fukuda K,
Hirota K (2009) The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1
activation. Eur J Pharmacol 617: 17-22
38. Kizaka-Kondoh S, Tanaka S, Hiraoka M (2009) Imaging and Targeting of the
Hypoxia-inducible Factor 1-active Microenvironment. Journal of Toxicologic Pathology 22:
93-100
39. Kudo T, Ueda M, Kuge Y, Mukai T, Tanaka S, Masutani M, Kiyono Y, Kizaka-Kondoh S,
Hiraoka M, Saji H (2009) Imaging of HIF-1-active tumor hypoxia using a protein effectively
delivered to and specifically stabilized in HIF-1-active tumor cells. J Nucl Med 50: 942-949
40. Makino A, Kizaka-Kondoh S, Yamahara R, Hara I, Kanzaki T, Ozeki E, Hiraoka M, Kimura S
(2009) Near-infrared fluorescence tumor imaging using nanocarrier composed of poly(L-lactic
acid)-block-poly(sarcosine) amphiphilic polydepsipeptide. Biomaterials 30: 5156-5160
70
41. Mitsumori M, Hiraoka M, Inaji H, Noguchi S, Oishi H, Kodama H, Koyama H (2009) Impact
of radiation therapy on breast-conserving therapy for breast cancer in Japanese women: a
retrospective analyses of multi-institutional experience. Kansai Breast Cancer Radiation
Therapy Study Group. Oncol Rep 21: 1461-1466
42. Nishimura Y, Mitsumori M, Hiraoka M, Koike R, Nakamatsu K, Kawamura M, Negoro Y,
Fujiwara K, Sakurai H, Mitsuhashi N (2009) A randomized phase II study of cisplatin/5-FU
concurrent chemoradiotherapy for esophageal cancer: Short-term infusion versus protracted
infusion chemotherapy (KROSG0101/JROSG021). Radiother Oncol 92: 260-265
43. Okubo K, Sonobe M, Fujinaga T, Shoji T, Sakai H, Miyahara R, Bando T, Date H, Shibuya K,
Hiraoka M (2009) Survival and relapse pattern after trimodality therapy for malignant pleural
mesothelioma. Gen Thorac Cardiovasc Surg 57: 585-590
44. Sakamoto T, Oya N, Shibuya K, Nagata Y, Hiraoka M (2009) Dose-response relationship and
dose optimization in radiotherapy of postoperative keloids. Radiother Oncol 91: 271-276
45. Abe E, Mizowaki T, Norihisa Y, Narita Y, Matsuo Y, Narabayashi M, Nagata Y, Hiraoka M
(2010) Impact of multileaf collimator width on intraprostatic dose painting plans for dominant
intraprostatic lesion of prostate cancer. J Appl Clin Med Phys 11: 3193
46. Chen F, Matsuo Y, Yoshizawa A, Sato T, Sakai H, Bando T, Okubo K, Shibuya K, Date H
(2010) Salvage lung resection for non-small cell lung cancer after stereotactic body
radiotherapy in initially operable patients. Journal of thoracic oncology : official publication of
the International Association for the Study of Lung Cancer 5: 1999-2002
47. Harada H, Hiraoka M (2010) Hypoxia-inducuble factor 1 in tumor radioresistance. Curr Signal
Transduct Ther 5: 188-196
48. Higgins GS, Prevo R, Lee YF, Helleday T, Muschel RJ, Taylor S, Yoshimura M, Hickson ID,
Bernhard EJ, McKenna WG (2010) A small interfering RNA screen of genes involved in DNA
repair identifies tumor-specific radiosensitization by POLQ knockdown. Cancer research 70:
2984-2993
49. Hiraoka M, Matsuo Y, Takayama K (2010) Stereotactic body radiation therapy for lung cancer:
achievements and perspectives. Japanese journal of clinical oncology 40: 846-854
50. Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M,
Halazonetis TD, Takeda S (2010) DNA polymerases nu and theta are required for efficient
71
immunoglobulin V gene diversification in chicken. The Journal of cell biology 189: 1117-1127
51. Komatsu H, Harada H, Tanabe K, Hiraoka M, Nishimoto S (2010) Indolequinon-rhodol
conjugate as fluorescent probe for hypoxic cells: enzymatic activation and fluorescence
properties. MedChemComm 1: 50-53
52. Kumar D, Kumar NM, Akamatsu K, Kusaka E, Harada H, Ito T (2010) Synthesis and
biological evaluation of indolyl chalcones as antitumor agents. Bioorg Med Chem Lett 20:
3916-3919
53. Matsuo Y, Nakamoto Y, Nagata Y, Shibuya K, Takayama K, Norihisa Y, Narabayashi M,
Mizowaki T, Saga T, Higashi T, Togashi K, Hiraoka M (2010) Characterization of FDG-PET
images after stereotactic body radiation therapy for lung cancer. Radiother Oncol 97: 200-204
54. Miki K, Oride K, Inoue S, Kuramochi Y, Nayak RR, Matsuoka H, Harada H, Hiraoka M, Ohe
K (2010) Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticles
for enhanced tumor imaging in vivo: Synergistic effect of folate-receptor targeting and
PEGylation. Biomaterials 31: 934-942
55. Nakamura M, Sawada A, Ishihara Y, Takayama K, Mizowaki T, Kaneko S, Yamashita M,
Tanabe H, Kokubo M, Hiraoka M (2010) Dosimetric characterization of a multileaf collimator
for a new four-dimensional image-guided radiotherapy system with a gimbaled x-ray head,
MHI-TM2000. Med Phys 37: 4684-4691
56. Sakamoto M, Mizowaki T, Mitsumori M, Takayama K, Sasai K, Norihisa Y, Kamoto T,
Nakamura E, Ogawa O, Hiraoka M (2010) Long-term outcomes of three-dimensional
conformal radiation therapy combined with neoadjuvant hormonal therapy in Japanese patients
with locally advanced prostate cancer. Int J Clin Oncol 15: 571-577
57. Takakura T, Mizowaki T, Nakata M, Yano S, Fujimoto T, Miyabe Y, Nakamura M, Hiraoka M
(2010) The geometric accuracy of frameless stereotactic radiosurgery using a 6D robotic couch
system. Phys Med Biol 55: 1-10
58. Zhao T, Harada H, Teramura Y, Tanaka S, Itasaka S, Morinibu A, Shinomiya K, Zhu Y,
Hanaoka H, Iwata H, Saji H, Hiraoka M (2010) A novel strategy to tag matrix
metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of
tumor cells. Journal of controlled release : official journal of the Controlled Release Society
144: 109-114
59. Li Z, Kawashita M, Araki N, Mitsumori M, Hiraoka M, Doi M (2010) Magnetite nanoparticles
72
with high heating efficiencies for application in the hyperthermia of cancer. Materials Science
and Engineering: C 30: 990-996
60. Miyazaki T, Kai T, Ishida E, Kawashita M, Hiraoka M (2010) Fabrication of yttria
microcapsules for radiotherapy from water/oil emulsion. Journal of the Ceramic Society of
Japan 118: 479-482
61. Toita T, Ohno T, Kaneyasu Y, Uno T, Yoshimura R, Kodaira T, Furutani K, Kasuya G,
Ishikura S, Kamura T, Hiraoka M, Group JCO (2010) A consensus-based guideline defining
the clinical target volume for pelvic lymph nodes in external beam radiotherapy for uterine
cervical cancer. Jpn J Clin Oncol 40: 456-463
62. Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh
S, Hiraoka M, Saji H (2010) Rapid detection of hypoxia-inducible factor-1-active tumours:
pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible
factor-1alpha. Eur J Nucl Med Mol Imaging 37: 1566-1574
63. Ushiki T, Kizaka-Kondoh S, Ashihara E, Tanaka S, Masuko M, Hirai H, Kimura S, Aizawa Y,
Maekawa T, Hiraoka M (2010) Noninvasive tracking of donor cell homing by near-infrared
fluorescence imaging shortly after bone marrow transplantation. PLoS One 5: e11114
64. Li Z, Kawashita M, Araki N, Mitsumori M, Hiraoka M, Doi M (2010) Magnetic SiO2 gel
microspheres for arterial embolization hyperthermia. Biomed Mater 5: 065010
65. Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-Kondoh S, Hiraoka M, Ito H, Takahashi R (2010)
Early protective effect of bone marrow mononuclear cells against ischemic white matter
damage through augmentation of cerebral blood flow. Stroke 41: 2938-2943
66. Cilek MZ, Hirohata S, Faruk Hatipoglu O, Ogawa H, Miyoshi T, Inagaki J, Ohtsuki T, Harada
H, Kamikawa S, Kusachi S, Ninomiya Y (2011) AHR, a novel acute hypoxia-response
sequence, drives reporter gene expression under hypoxia in vitro and in vivo. Cell Biol Int 35:
1-8
67. Daijo H, Kai S, Tanaka T, Wakamatsu T, Kishimoto S, Suzuki K, Harada H, Takabuchi S,
Adachi T, Fukuda K, Hirota K (2011) Fentanyl activates hypoxia-inducible factor 1 in neuronal
SH-SY5Y cells and mice under non-hypoxic conditions in a mu-opioid receptor-dependent
manner. Eur J Pharmacol 667: 144-152
68. Harada H (2011) Gene Therapy Strategy for Tumor Hypoxia. In Targets in Gene Therapy, You
Y (ed), Vol. 11, pp 185-200. Intech
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69. Harada H (2011) How can we overcome tumor hypoxia in radiation therapy? J Radiat Res 52:
545-556
70. Higashi T, Nishii R, Yamada S, Nakamoto Y, Ishizu K, Kawase S, Togashi K, Itasaka S,
Hiraoka M, Misaki T, Konishi J (2011) Delayed initial radioactive iodine therapy resulted in
poor survival in patients with metastatic differentiated thyroid carcinoma: a retrospective
statistical analysis of 198 cases. Journal of nuclear medicine : official publication, Society of
Nuclear Medicine 52: 683-689
71. Kamomae T, Miyabe Y, Sawada A, Matoba O, Nakata M, Yano S, Takakura T, Mizowaki T,
Itoh A, Hiraoka M (2011) Simulation for improvement of system sensitivity of radiochromic
film dosimetry with different band-pass filters and scanner light intensities. Radiological
physics and technology 4: 140-147
72. Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R
(2011) Angiogenic roles of adrenomedullin through vascular endothelial growth factor
induction. Neuroreport 22: 442-447
73. Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H,
Harada H, Yokoi H, Arai H, Itoh H, Nakao K, Takahashi R, Tomimoto H (2011) Angiogenic
and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic
cerebral hypoperfusion in mice. Stroke 42: 1122-1128
74. Makino A, Harada H, Okada T, Kimura H, Amano H, Saji H, Hiraoka M, Kimura S (2011)
Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation
as an MRI contrast agent. Nanomedicine 7: 638-646
75. Matsuo Y, Shibuya K, Nagata Y, Takayama K, Norihisa Y, Mizowaki T, Narabayashi M,
Sakanaka K, Hiraoka M (2011) Prognostic factors in stereotactic body radiotherapy for
non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 79: 1104-1111
76. Matsuo Y, Shibuya K, Narabayashi M, Hiraoka M. (2011) Stereotactic Body Radiotherapy for
the Lung. In De Salles AAF, Gorgulho A, Agazaryan N, Slotman B, Selch M, Burwick AJ,
Schulz R (eds.), Shaped Beam Radiosurgery. Springer Berlin Heidelberg, pp. 267-277.
77. Miki K, Kimura A, Oride K, Kuramochi Y, Matsuoka H, Harada H, Hiraoka M, Ohe K (2011)
High-contrast fluorescence imaging of tumors in vivo using nanoparticles of amphiphilic
brush-like copolymers produced by ROMP. Angew Chem Int Ed Engl 50: 6567-6570
74
78. Miki K, Oride K, Kimura A, Kuramochi Y, Matsuoka H, Harada H, Hiraoka M, Ohe K (2011)
Influence of side chain length on fluorescence intensity of ROMP-based polymeric
nanoparticles and their tumor specificity in in-vivo tumor imaging. Small 7: 3536-3547
79. Miyabe Y, Sawada A, Takayama K, Kaneko S, Mizowaki T, Kokubo M, Hiraoka M (2011)
Positioning accuracy of a new image-guided radiotherapy system. Med Phys 38: 2535-2541
80. Mizowaki T, Takayama K, Norihisa Y, Ogura M, Kamba T, Inoue T, Shimizu Y, Kamoto T,
Ogawa O, Hiraoka M (2011) Long-term outcomes of three-dimensional conformal radiation
therapy combined with neoadjuvant hormonal therapy for Japanese patients with T1c-T2N0M0
prostate cancer. Int J Clin Oncol
81. ○ Nakamura M, Shibuya K, Shiinoki T, Matsuo Y, Nakamura A, Nakata M, Sawada A,
Mizowaki T, Hiraoka M (2011) Positional reproducibility of pancreatic tumors under
end-exhalation breath-hold conditions using a visual feedback technique. Int J Radiat Oncol
Biol Phys 79: 1565-1571
82. Norihisa Y, Mizowaki T, Takayama K, Miyabe Y, Matsugi K, Matsuo Y, Narabayashi M,
Sakanaka K, Nakamura A, Nagata Y, Hiraoka M (2011) Detailed dosimetric evaluation of
intensity-modulated radiation therapy plans created for stage C prostate cancer based on a
planning protocol. Int J Clin Oncol
83. Ogawa K, Nakamura K, Sasaki T, Onishi H, Koizumi M, Araya M, Mukumoto N, Teshima T,
Mitsumori M, Japanese Patterns of Care Study Working Subgroup of Prostate C (2011) Radical
external beam radiotherapy for clinically localized prostate cancer in Japan: changing trends in
the patterns of care process survey. Int J Radiat Oncol Biol Phys 81: 1310-1318
84. Saha D, Dunn H, Zhou H, Harada H, Hiraoka M, Mason RP, Zhao D (2011) In vivo
bioluminescence imaging of tumor hypoxia dynamics of breast cancer brain metastasis in a
mouse model. J Vis Exp
85. Sakanaka K, Mizowaki T, Arakawa Y, Araki N, Oya N, Takahashi JA, Mikuni N, Miyamoto S,
Hashimoto N, Hiraoka M (2011) Hypofractionated stereotactic radiotherapy for acoustic
neuromas: safety and effectiveness over 8 years of experience. Int J Clin Oncol 16: 27-32
86. Shibuya K, Oya N, Fujii T, Doi R, Nakamura A, Matsuo Y, Mitsumori M, Hiraoka M (2011)
Phase II study of radiation therapy combined with weekly low-dose gemcitabine for locally
advanced, unresectable pancreatic cancer. American journal of clinical oncology 34: 115-119
87. ○ Shiinoki T, Shibuya K, Nakamura M, Nakamura A, Matsuo Y, Nakata M, Sawada A,
75
Mizowaki T, Itoh A, Hiraoka M (2011) Interfractional reproducibility in pancreatic position
based on four-dimensional computed tomography. Int J Radiat Oncol Biol Phys 80: 1567-1572
88. Soejima T, Yoden E, Y NI, Ono S, Yoshida A, Fukuda H, Fukuhara N, Sasaki R, Tsujino K,
Norihisa Y (2011) Radiation therapy in patients with implanted cardiac pacemakers and
implantable cardioverter defibrillators: a prospective survey in Japan. J Radiat Res (Tokyo) 52:
516-521
89. Takayama K, Mizowaki T, Negoro Y, Norihisa Y, Hiraoka M (2011) Impact of double-balloon
rectal catheter use in external-beam radiotherapy for prostate cancer. Int J Clin Oncol 16: 50-56
90. Toita T, Ohno T, Kaneyasu Y, Kato T, Uno T, Hatano K, Norihisa Y, Kasamatsu T, Kodaira T,
Yoshimura R, Ishikura S, Hiraoka M (2011) A consensus-based guideline defining clinical
target volume for primary disease in external beam radiotherapy for intact uterine cervical
cancer. Jpn J Clin Oncol 41: 1119-1126
91. Yeom CJ, Zeng L, Zhu J, Hiraoka M, Harada H (2011) Strategies to assess
hypoxic/HIF-1-active cancer cells for the development ofinnovative radiation therapy. Cancers
3: 3610-3631
92. Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S,
Kizaka-Kondoh S, Hiraoka M, Saji H (2011) PET imaging of hypoxia-inducible factor-1-active
tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel
18F-labeled biotin derivative. Mol Imaging Biol 13: 1003-1010
93. Ishikura S, Ito Y, Hiraoka M (2011) JCOG Radiation Therapy Study Group: history and
achievements. Jpn J Clin Oncol 41: 1241-1243
94. Li Z, Kawashita M, Araki N, Mitsumori M, Hiraoka M, Doi M (2011) Preparation of magnetic
iron oxide nanoparticles for hyperthermia of cancer in a FeCl?-NaNO?-NaOH aqueous system.
J Biomater Appl 25: 643-661
95. Nakajima A, Nishiyama K, Morimoto M, Nakamura S, Suzuki O, Kawaguchi Y, Miyagi K,
Fujii T, Yoshino K (2012) Definitive radiotherapy for T1-2 hypopharyngeal cancer: a
single-institution experience. Int J Radiat Oncol Biol Phys 82: e129-135
96. Toi M, Winer EP, Inamoto T, Benson JR, Forbes JF, Mitsumori M, Robertson JF, Sasano H,
von Minckwitz G, Yamauchi A, Klimberg VS (2011) Identifying gaps in the locoregional
management of early breast cancer: highlights from the kyoto consensus conference. Ann Surg
Oncol 18: 2885-2892
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97. Tomita N, Toita T, Kodaira T, Shinoda A, Uno T, Numasaki H, Teshima T, Mitsumori M
(2011) Changing trend in the patterns of pretreatment diagnostic assessment for patients with
cervical cancer in Japan. Gynecol Oncol 123: 577-580
98. Ueda M, Kudo T, Mutou Y, Umeda IO, Miyano A, Ogawa K, Ono M, Fujii H, Kizaka-Kondoh
S, Hiraoka M, Saji H (2011) Evaluation of [125I]IPOS as a molecular imaging probe for
hypoxia-inducible factor-1-active regions in a tumor: comparison among single-photon
emission computed tomography/X-ray computed tomography imaging, autoradiography, and
immunohistochemistry. Cancer Sci 102: 2090-2096
99. Fokas E, Yoshimura M, Prevo R, Higgins G, Hackl W, Maira SM, Bernhard EJ, McKenna WG,
Muschel RJ (2012) NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol
3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell
radiosensitivity. Radiation oncology 7: 48
100. Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y,
Yoshimura M, McKenna WG, Muschel RJ, Hiraoka M (2012) Cancer cells that survive
radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nature
communications 3: 783
101. Kai S, Tanaka T, Daijo H, Harada H, Kishimoto S, Suzuki K, Takabuchi S, Takenaga K,
Fukuda K, Hirota K (2012) Hydrogen sulfide inhibits hypoxia- but not anoxia-induced
hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent
manner. Antioxid Redox Signal 16: 203-216
102. Matsuo Y, Shibuya K, Nagata Y, Norihisa Y, Narabayashi M, Sakanaka K, Ueki N, Mizowaki
T, Hiraoka M (2012) Preliminary report of late recurrences, at 5 years or more, after
stereotactic body radiation therapy for non-small cell lung cancer. J Thorac Oncol 7: 453-456
103. Matsuo Y, Shibuya K, Nakamura M, Narabayashi M, Sakanaka K, Ueki N, Miyagi K,
Norihisa Y, Mizowaki T, Nagata Y, Hiraoka M (2012) Dose-Volume Metrics Associated With
Radiation Pneumonitis After Stereotactic Body Radiation Therapy For Lung Cancer. Int J
Radiat Oncol Biol Phys
104. Mizowaki T, Takayama K, Norihisa Y, Ogura M, Kamba T, Inoue T, Shimizu Y, Kamoto T,
Ogawa O, Hiraoka M (2012) Long-term outcomes of three-dimensional conformal radiation
therapy combined with neoadjuvant hormonal therapy for Japanese patients with T1c-T2N0M0
prostate cancer. International journal of clinical oncology / Japan Society of Clinical Oncology
77
105. Nakamura A, Shibuya K, Matsuo Y, Nakamura M, Shiinoki T, Mizowaki T, Hiraoka M
(2012) Analysis of Dosimetric Parameters Associated With Acute Gastrointestinal Toxicity and
Upper Gastrointestinal Bleeding in Locally Advanced Pancreatic Cancer Patients Treated With
Gemcitabine-Based Concurrent Chemoradiotherapy. Int J Radiat Oncol Biol Phys
106. Nakamura K, Akimoto T, Mizowaki T, Hatano K, Kodaira T, Nakamura N, Kozuka T,
Shikama N, Kagami Y (2012) Patterns of Practice in Intensity-modulated Radiation Therapy
and Image-guided Radiation Therapy for Prostate Cancer in Japan. Japanese journal of clinical
oncology 42: 53-57
107. ○ Nakamura M, Kishimoto S, Iwamura K, Shiinoki T, Nakamura A, Matsuo Y, Shibuya K,
Hiraoka M (2012) Dosimetric investigation of breath-hold intensity-modulated radiotherapy for
pancreatic cancer. Med Phys 39: 48-54
108. ○ Nakamura M, Miyabe Y, Matsuo Y, Kamomae T, Nakata M, Yano S, Sawada A,
Mizowaki T, Hiraoka M (2012) Experimental validation of heterogeneity-corrected
dose-volume prescription on respiratory-averaged CT images in stereotactic body radiotherapy
for moving tumors. Med Dosim 37: 20-25
109. ○ Nakamura M, Shibuya K, Nakamura A, Shiinoki T, Matsuo Y, Nakata M, Sawada A,
Mizowaki T, Hiraoka M (2012) Interfractional dose variations in intensity-modulated
radiotherapy with breath-hold for pancreatic cancer. Int J Radiat Oncol Biol Phys 82:
1619-1626
110. Nishimura Y, Koike R, Ogawa K, Sasamoto R, Murakami Y, Itoh Y, Negoro Y, Itasaka S,
Sakayauchi T, Tamamoto T (2012) Clinical practice and outcome of radiotherapy for
esophageal cancer between 1999 and 2003: the Japanese Radiation Oncology Study Group
(JROSG) Survey. Int J Clin Oncol 17: 48-54
111. ○ Sakanaka K, Mizowaki T, Hiraoka M (2012) Dosimetric advantage of intensity-modulated
radiotherapy for whole ventricles in the treatment of localized intracranial germinoma. Int J
Radiat Oncol Biol Phys 82: e273-280
112. Yoshimura M, Hiraoka M, Harada H (2012) Molecularly based Chemoradiotherapy and
High-Precision Radiotherapy. In Principles of Molecular Diagnostics and Personalized Cancer
Medicine, Tan D, Lynch H (eds), p in press. Lippincott Williams & Milkins
113. Zhu Y, Zhao T, Itasaka S, Zeng L, Yeom CJ, Hirota K, Suzuki K, Morinibu A, Shinomiya K,
Ou G, Yoshimura M, Hiraoka M, Harada H (2012) Involvement of decreased
hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance
78
of perinecrotic tumor cells. Oncogene
114. Nozaki M, Kagami Y, Mitsumori M, Hiraoka M (2012) A multicenter investigation of late
adverse events in Japanese women treated with breast-conserving surgery plus conventional
fractionated whole-breast radiation therapy. Jpn J Clin Oncol 42: 522-527
115. Saji S, Hiraoka M, Tokuda Y, Fukui N, Ikeda T (2012) Trends in local therapy application for
early breast cancer patients in the Japanese Breast Cancer Society Breast Cancer Registry
during 2004-2009. Breast Cancer 19: 1-3
116. ○ Narabayashi M, Mizowaki T, Matsuo Y, Nakamura M, Takayama K, Norihisa Y,
Sakanaka K, Hiraoka M (2012) Dosimetric evaluation of the impacts of different heterogeneity
correction algorithms on target doses in stereotactic body radiation therapy for lung tumors. J
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12) Nobuya Inagaki
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X., Toyoda, K., Seino, Y., and Inagaki, N. A novel gastric inhibitory polypeptide (GIP) receptor
splice variant influences GIP sensitivity of pancreatic β-cells in obese mice. Am. J. Physiol.
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2. Toyoda, K., Fukushima, M., Mitsui, R., Harada, N., Suzuki, H., Takeda, T., Taniguchi, A., Nakai,
Y., Kawakita, T., Yamada, Y., Inagaki, N., and Seino, Y. Factors responsible for age-related
elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Metabolism. 57:
299-303, 2008.
3. Nakamura, Y., Ogura, M., Tanaka, D., and Inagaki, N. Localization of mouse mitochondrial SIRT
proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem. Biophys. Res.
Commun. 366: 174-179, 2008. (Top Cited Article 2008-2010 Award of Biochemical and
Biophysical Research Communications)
4. Toyoda, K., Okitsu, T., Yamane, S., Uonaga, T., Liu, X., Harada, N., Uemoto, S., Seino, Y., and
Inagaki, N. GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant
by inhibiting apoptosis. Biochem. Biophys. Res. Commun., 367: 793-798, 2008.
5. Yamada, C., Yamada, Y., Tsukiyama, K., Yamada, K., Udagawa, N., Takahashi, N., Tanaka, K.,
Drucker, D. J., Seino, Y., and Inagaki, N. The murine Glp1r is essential for control of bone
resorption. Endocrinology 149: 574-579, 2008.
79
6. Fujita, Y., Fukushima, M., Suzuki, H., Taniguchi, A., Nakai, Y., Kuroe, A., Yasuda, K., Hosokawa,
M., Yamada, Y., Inagaki, N., and Seino, Y. Short-term intensive glycemic control improves
vibratory sensation in type 2 diabetes. Diabetes Res. Clin. Pract., 80: 16-19, 2008.
7. Yamada, K., Hosokawa, M., Fujimoto, S., Fujiwara, H., Fujita, Y., Harada, N., Yamada, C.,
Fukushima, M., Ueda, N., Kaneko, T., Matsuyama, F., Yamada, Y., Seino, Y., and Inagaki, N.
Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Res. Clin. Pract. 80: 48-55,
2008.
8. Yamada, K., Hosokawa, M., Yamada, C., Watanabe, R., Fujimoto, S., Fujiwara, H., Kunitomo,
M., Miura, T., Kaneko, T., Tsuda, K., Seino, Y., and Inagaki, N. Dietary Corosolic Acid
Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice. Biol. Pharm. Bull. 31: 651-655,
2008.
9. Fujiwara, H., Hosokawa, M., Zhou, X., Fujimoto, S., Fukuda, K., Toyoda, K., Nishi, Y., Fujita, Y.,
Yamada, K., Yamada, Y., Seino, Y., and Inagaki, N. Curcumin inhibits glucose production in
isolated mice hepatocytes. Diabetes Res. Clin. Pract. 80: 185-191, 2008.
10. Yokota, T.*, Matsumura, Y.*, Ban, N., Matsubayashi, T., and Inagaki, N. Heterozygous ABCA3
mutation associated with non-fatal evolution of respiratory distress. Eur. J. Pe diatr. 167:
691-693, 2008. (*; equal contribution)
11. Aramaki, Y., Mitsuoka, H., Toyohara, M., Jinnai, T., Kanatani, K., Nakajima, K., Mukai, E.,
Yamada, Y., Kita, T., Inagaki, N., and Kume, N. Lectin-like LDL receptor-1 (LOX-1) acts as a
receptor for remnant-like lipoprotein particles (PLPs) and mediates RLP-induced migration of
vascular smooth muscle cells. Atherosclerosis 198: 272-279, 2008.
12. Kominato, R., Fujimoto, S., Mukai, E., Nakamura, Y., Nabe, K., Shimodahira, M., Nishi, Y.,
Funakoshi, S., Seino, Y., and Inagaki, N. Src activation generates reactive oxygen species and
impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat
pancreatic islets. Diabetologia 51: 1226-1235, 2008.
13. Chapuy, B., Koch, R., Radunski, U., Corsham, S., Cheong, N., Inagaki, N., Ban, N., Wenzel, D.,
Reinhardt, D., Zapf, A., Schweyer, S., Kosari, F., Klapper, W., Truemper, L., and Wulf, G. G.
Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal
drug sequestration. Leukemia 22: 1576-1586, 2008.
14. Sassa, M., Yamada, Y., Hosokawa, M., Fukuda, K., Fujimoto, S., Toyoda, K., Tsukiyama, K.,
Seino, Y., and Inagaki, N. Glycemic instability in type 1 diabetic patients: Possible role of
ketosis or ketoacidosis at onset of diabetes. Diabetes Res. Clin. Pract. 81: 191-195, 2008.
80
15. Harada, N., Fukushima, M., Toyoda, K., Mitsui, R., Izuka, T., Taniguchi, A., Nakai, Y., Yamada,
Y., Seino, Y., and Inagaki, N. Factors responsible for elevation of 1-h postchallenge plasma
glucose levels in Japanese men. Diabetes Res. Clin. Pract. 81: 284-289, 2008.
16. Matsumura, Y., Ban, N., and Inagaki, N. Aberrant catalytic cycle and impaired lipid transport
into intracellular vesicles in ABCA3 mutants associated with nonfatal pediatric interstitial lung
disease. Am. J. Physiol.-Lung Cell. Mol. Physiol. 295：L698-707, 2008.
17. Naito, R., Miyawaki, K., Harada, N., Mizunoya, W., Toyoda, K., Fushiki, T., Yamada, Y., Seino,
Y., and Inagaki, N. Inhibition of GIP signaling modulates adiponectin levels under high-fat diet
in mice. Biochem. Biophys. Res. Commun. 376: 21-25, 2008.
18. Funakoshi, S., Fujimoto, S., Hamasaki, A., Fujiwara, H., Fujita, Y., Hamamoto, Y., Hosokawa,
M., Seino, Y., and Inagaki, N. Analysis of factors influencing pancreatic β-cell function in
Japanese patients with type 2 diabetes: association with body mass index and duration of
diabetic exposure. Diabetes Res. Clin. Pract. 82: 353-358, 2008.
19. Koshiyama, H., Taniguchi, A., Tanaka, K., Kagimoto, S., Fujioka, Y., Hirata, K., Nakamura, Y.,
Iwakura, A., Hara, K., Yamamoto, T., Kuroe, A., Ohya, M., Fujimoto, S., Hamamoto, Y., Honjo,
S., Ikeda, H., Nabe, K., Tsuda, K., Inagaki, N., Seino, Y., and Kume, N. Effects of pitavastatin
on lipid profiles and high-sensitivity CRP in Japanese subjects with hypercholesterolemia:
Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and
Endocrinology (KISHIMEN) investigatars. J. Atheroscler. Thromb. 15:345-50, 2008.
20. Kuwabara, A., Tanaka, K., Tsugawa, N., Nakase, H., Tsuji, H., Shide, K., Kamao, M., Chiba, T.,
Inagaki, N., Okano, T., and Kido, S. High prevalence of vitamin K and D deficiency and
decreased BMD in inflammatory bowel disease. Osteoporos Int. 20: 935-942, 2009.
21. Liu, X.-B., Harada, N., Yamane, S., Kitajima, L., Uchida, S., Hamasaki, A., Mukai, E., Toyoda,
K., Yamada, C., Hamamoto, Y., Yamada, Y., Seino, Y., and Inagaki, N. Effects of long-term
DPP-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice. Life
Sci. 84: 876-881, 2009.
22. Mukai, E., Toyoda, K., Kimura, H., Kawashima, H., Fujimoto, H., Ueda, M., Temma, T., Hirao,
K., Nagakawa, K., Saji, H., and Inagaki N. GLP-1 receptor antagonist as a potential probe for
pancreatic β-cell imaging. Biochem. Biophys. Res. Commun. 389: 523-526, 2009.
23. ○ Chapuy, B., Panse, M., Radunski, U., Koch, R., Wenzel, D., Inagaki, N., Haase, D.,
Truemper, L., Wulf, G. G., ABC transporter A3 facilitates lysosomal sequestration of imatinib
81
and modulates susceptibility of chronic myeloid leukemia cell lines to this drug.
Haematologica 94: 1528-1536, 2009.
24. Shimodahira, M., Fujimoto, S., Mukai, E., Nakamura, Y., Nishi, Y., Sasaki, M., Sato, Y., Sato,
H., Hosokawa, M., Nagashima, K., Seino, Y., and Inagaki, N. Rapamycin impairs
metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism
in the Krebs cycle. J. Endocrinol.204: 37-46, 2010.
25. ○ Park, S.-K., Amos, L., Rao, A., Quasney, M.W., Matsumura, Y., Inagaki, N., and Dahmer, M.
K. A novel ABCA3 mutation in a premature infant with chronic respiratory insufficiency.
Physiol. Genomics 40: 94-99, 2010.
26. ○ Toyama, K., Yonezawa, A., Tsuda, M., Masuda, S., Yano, I., Terada, T., Ogawa, R., Katsura,
T., Hosokawa, M., Fujimoto, S., Inagaki, N., and Inui, K.-I. Heterozygous variants of multidrug
and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of
metformin in diabetic patients. Pharmacogenet. Genomics 20: 135-138, 2010.
27. Ogura, M., Nakamura, Y., Tanaka, D., Zhuang, X.-T., Fujita, Y., Obara, A., Hamasaki, A.,
Hosokawa, M., and Inagaki N. Overexpression of SIRT5 confirms its involvement in
deacetylation and activation of carbamoyl phosphate synthethase 1. Biochem. Biophys. Res.
Commun. 393: 73-78, 2010.
28. ○ Sato, S., Ishida-Nakajima, W., Ishida, A., Kawamura, M., Miura, S., Ono, K., Inagaki, N.,
Takada, G., and Takahashi, T. Assessment of a new piezoelectric transducer sensor for
noninvasive cardiorespiratory monitoring of newborn infants in the NICU. Neonatology 98:
179-190, 2010.
29. Kawasaki, Y., Harashima, S.-I., Sasaki, M., Mukai, E., Nakamura, Y., Harada, N., Toyoda, K.,
Hamasaki, A., Yamane, S., Yamada, C., Yamada, Y., Seino Y., and Inagaki N. Exendin-4
protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38
phosphorylation. Horm. Metab. Res. 42: 311-317, 2010.
30. Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, C. F.,
Holst, J. J., Hirano, T., Inagaki, N., and Seino, Y. Little enhancement of meal-induced GLP-1
secretion in Japanese: comparison of type 2 diabetes and healthy controls. J. Diabetes. Invest.
1: 56-59, 2010.
31. Fujita, Y., Hosokawa, M., Fujimoto, S., Mukai, E., Abudukadier, A., Obara, A., Ogura, M.,
Nakamura Y., Toyoda, K., Nagashima, K., Seino, Y., and Inagaki, N. Metformin suppresses
hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen
82
species. Diabetologia 53: 1472-1481, 2010.
32. Uonaga, T., Toyoda, K., Okitsu, T., Liu, X.-B., Yamane, S., Uemoto, S., and Inagaki, N.
FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model. Islets 2:
247-251, 2010.
33. Yoneda, K., Demitsu, T., Manabe, M., Igarashi, J., Kosaka, H., Inagaki, N., Takahashi, H., Kon,
A., Kakurai, M., and Kubota, Y. Expression of wild-type, but not mutant, loricrin causes
programmed cell death in HaCaT keratinocytes. J. Dermatol. 37: 956-964, 2010.
34. ○ Yoshihara, E., Fujimoto, S., Inagaki, N., Okawa, K., Masaki, S., Yodoi, J., and Masutani, H.
Disruption of TBP-2/Txnip ameliorates insulin sensitivity and secretion without affecting
obesity. Nat. Commun. Nov. 23; 1: 127, 2010 (doi: 10.1038/ncomms1127).
35. Kuwabara, A., Nakase, H., Tsuji, H., Shide, K., Chiba, T., Inagaki, N., and Tanaka, K. Fat
restriction is associated with impaired quality of life (QOL) in patients with ulcerative colitis
and Crohn’s disease. Ulcers, Article ID 594532, doi:10.1155/2011/594532, 2011
36. Mukai, E., Fujimoto, S., Sato, H., Oneyama, C., Kominato, R., Sato, Y., Sasaki, M., Nishi, Y.,
Okada, M., and Inagaki, N. Exendin-4 suppresses Src activation and reactive oxygen species
production in diabetic GK rat islets in an Epac-dependent manner. Diabetes 60:218-226, 2011
37. Ogawa, E., Hosokawa, M., Harada, N., Yamane, S., Hamasaki, A., Toyoda, K., Fujimoto, S.,
Fujita, Y., Fukuda, K., Tsukiyama, K., Yamada, Y., Seino, Y., and Inagaki N. The effect of
gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice.
Biochem. Biophys. Res. Commun. 404: 115-120, 2011.
38. Tanaka, D., Nagashima, K., Sasaki, M., Yamada, C., Funakoshi, S., Akitomo, K., Takenaka, K.,
Harada, K., Koizumi, A., and Inagaki N. GCKR mutations in Japanese families with clustered
type 2 diabetes. Mol. Genet. Metab. 102: 453-.460, 2011.
39. Yamane, S., Hamamoto, Y., Harashima, S.-I., Harada, N., Hamasaki, A., Toyoda, K., Fujita,
Joo, E., and Inagaki, N. GLP-1 receptor agonist attenuates ER stress-mediated β-cell damage in
Akita mice. J. Diabtes Invest. 2: 104-110, 2011.
40. Harada, N., Hamasaki, A., Yamane, S., Muraoka, A., Joo, E., Fujita, K., and Inagaki, N. Plasma
gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are
associated with different factors in Japanese subjects. J. Diabtes Invest. 2: 193-199, 2011.
41. Yamada, C., Fujimoto, S., Ikeda, K., Nomura, Y., Matsubara, A., Kanno, M., Shide, K., Tanaka,
83
K., Imai, E., Fukuwatari, T., Shibata, K., and Inagaki, N. Relation of homocysteine and
homocysteine-related vitamins to bone mineral density in Japanese patients with type 2
diabetes. J. Diabtes Invest. 2: 233-239, 2011.
42. Nishi, Y., Fujimoto, S., Sasaki, M., Mukai, E., Sato, H., Sato, Y., Tahara, Y., Nakamura, Y.,
and Inagaki, N. Role of mitochondrial phosphate carrier in metabolism-secretion coupling in
rat insulinoma cell line INS-1. Biochem. J. 435: 421-430, 2011.
43. Fujimoto, H., Toyoda, K., Okitsu, T., Liu, X., Mukai, E., Zhuang, X.-T., Uemoto, S., Mochizuki,
N., and Inagaki N. Three dimensional ex vivo imaging and analysis of intraportal islet
transplants. Transpl. Int. 24: 839-844, 2011.
44. Harashima, S.-I., Wang, Y., Horiuchi, T., Seino, Y., and Inagaki, N. Purkinje cell protein 4
positively regulates neurite outgrowth and neurotransmitter release. J. Neur osci. Res. 89:
1519-1530.
45. ○ Cha, C.-Y., Nakamura, Y., Himeno, Y., Wang, J., Fujimoto, S., Inagaki, N., Earm, Y. E.,
and Noma, A. Ionic mechanisms and Ca2+ dynamics underlying the glucose response of
pancreatic β-cells: A simulation study. J. Gen. Physiol. 138: 21-37, 2011.
46. Funakoshi, S., Fujimoto, S., Hamasaki, A., Fujiwara, H., Fujita, Y., Ikeda, K., Takahara, S.,
Nagashima, K., Hosokawa, M., Seino, Y., and Inagaki, N. Utility of indices using C-peptide
levels for indication of insulin therapy to achieve good glycemic control in Japanese patients
with type 2 diabetes. J. Diabtes Invest. 2: 297-303, 2011.
47. ○ Himeno, T., Kamiya, H., Naruse, K., Harada, N., Ozaki, N., Seino, Y., Shibata, T., Kondo,
M., Kato, J., Okawa, T., Fukami, A., Hamada, Y., Inagaki, N., Seino, Y., Drucker, D. J., Oiso,
Y., and Nakamura, J. Beneficial effects of exendin-4 on experimental polyneuropathy in
diabetic mice. Diabetes 60: 2397-2406, 2011.
48. ○ Cifuentes, M., Pérez-Martín, M., Grondona, J. M., López-Ávalos, M. D., Inagaki, N.,
Granados-Durán, P., Rivera, P., and Fernández-Llebrez, P. A comparative analysis of
intraperitoneal versus intracerebroventricular administration of bromodeoxyuridine for the
study of cell proliferation in the adult rat brain. J. Neurosci. Methods 201: 307-314, 2011.
49. ○ Takeda, Y., Amano, A., Noma, A., Nakamura, Y., Fujimoto, S., and Inagaki, N. Systems
analysis of GLP-1 receptor signaling in pancreatic β-cells. Am. J. Physiol.-Ce ll Physiol. 301:
C792-803, 2011.
50. Shihara, N., Kitaoka, M., Inagaki, N., Kadowaki, T., Koumoto, S., Satoh, J., Terauchi, Y.,
84
Nunoi, K., Yamada, Y., Sakamaki, H., and Seino, Y. Randomized controlled trial of
single-agent glimepiride and pioglitazone in Japanese patients with type 2 diabetes: A
comparative study. J. Diabetes Invest. 2: 391-398, 2011.
51. Ikeda, K., Fujimoto, S., Goto, M., Yamada, C., Hamasaki, A., Shide, K., Kawamura, T., and
Inagaki, N. Impact of endogenous and exogenous insulin on basal energy expenditure in
patients with type 2 diabetes under standard treatment. Am. J. Clin. Nutr ., 94: 1513-1518,
2011.
52. Funakoshi, S., Fujimoto, S., Hamasaki, A., Fujiwara, H., Fujita, Y., Ikeda, K., Takahara, S.,
Seino, Y., and Inagaki, N. Analysis of factors influencing postprandial C peptide levels in
Japanese patients with type 2 diabetes: Comparison with C peptide levels after glucagon load. J.
Diabtes Invest. 2: 429-434, 2011.
53. Inagaki, N., Ueki, K., Yamamura, A., Saito, H., and Imaoka, T. Long-term safety and efficacy
of exenatide twice daily in Japanese patients with suboptimally controlled type 2 diabetes J.
Diabetes Invest. 2: 448-456, 2011.
54. ○ Flamein, F., Riffault, L., Muselet-Charlier, C., Pernelle, J., Feldmann, D., Jonald, L.,
Durand-Schneider, A.M., Coulomb, A., Maurice, M., Nogee, L. M., Inagaki, N., Amselem, S.,
Dubus, J. C., Rigourd, V., Brémont, F., Marguet, C., Brouard, J., de Blic, J., Clement, A.,
Epaud, R., and Guillot, L. Molecular and cellular characteristics of ABCA3 mutation
associated with diffuse parenchymal lung diseases in children. Hum. Mol. Genet.21: 765-775,
2012.
55. ○ Morales, C. R., Ni, X.-Y., Smith, C. E., Inagaki, N., and Hermo, L. ABCA17 mediates sterol
efflux from mouse spermatozoa plasma membranes. Histol. Histopathol. 27: 317-328, 2012.
56. Harashima, S.-I., Horiuchi, T., Wang, Y., Notkins, A. L., Seino, Y., and Inagaki, N.
Sortingnexin 19 regulates the number of dense core vesicles in pancreatic β-cells. J. Diabtes
Invest. 3: 52-61, 2012.
57. Yabe, D., Watanabe, K., Sugawara, K., Kuwata, H., Kitamoto, Y., Sugizaki, K., Fujiwara, S.,
Hishizawa, M., Hyo, T., Kuwabara, K., Yokota, K., Iwasaki, M., Kitatani, N., Kurose, T.,
Inagaki, N., and Seino, Y. Comparison of incretin immunoassays with or without plasma
extraction: correlation of clinical characteristics and incretin secretion in Japanese patients with
type 2 diabetes. J. Diabtes Invest., 3: 70-79, 2012.
58. Yamane, S., Harada, N., Hamasaki, A., Muraoka, A., Joo, E., Suzuki, K., Nasteska, D., Tanaka,
D., Ogura, M., Harashima, S.-I., and Inagaki, N. The effects of glucose and meal ingestion on
85
incretin secretion in Japanese subjects with normal glucose tolerance. J. Diabtes Invest. 3:
80-85, 2012.
59. Kawamori, R., Inagaki, N., Araki, E., Watada, H., Hayashi, N., Horie, Y., Sarashina, A., Gong,
Y., von Eynatten, M., Woerle, H. J., and Dugi, K. A. Linagliptin monotherapy provides
superior glycaemic control versus placebo or voglibose with comparable safety in Japanese
patients with type 2 diabetes: a randomized, placebo and active comparator-controlled,
double-blind study. Diabetes Obes. Metab. 14: 348-357, 2012.
60. Harashima, S., Ogura, M., Tanaka, D., Fukushima, T., Wang, Y., Koizumi, T., Aono, M.,
Murata, Y., Seike, M., and Inagaki, N. Sitagliptin add-on to low dosage sulfonylureas:
efficacy and safety of combination therapy on glycemic control and insulin secretion capacity
in type 2 diabetes. Int. J. Clin. Pract. 66: 465-476, 2012.
61. ○ Toyama, K., Yonezawa, A., Masuda, S., Osawa, R., Hosokawa, M., Fujimoto, S., Inagaki,
N., Inui, K.-I., and Katsura, T. Loss of multidrug and toxin extrusion (MATE 1) is associated
with metformin-induced lactic acidosis. Br. J. Pharmacol. 166: 1183-1191.
62. Sakamoto, E., Seino, Y., Fukami, A., Mizutani, N., Tsunekawa, S., Ishikawa, K., Ogata, H.,
Uenishi, E., Kamiya, H., Hamada, Y., Sato, H., Harada, N., Toyoda, Y., Miwa, I., Nakamura, J.,
Inagaki, N., Oiso, Y., and Ozaki, N. Ingestion of a moderate high-sucrose diet results in
glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like
peptide-1 secretion. J. Diabtes Invest., in press.
63. Mitsui, R., Fukushima, M., Taniguchi, A., Nakai, Y., Aoyama, S., Takahashi, Y., Tsuji, H.,
Yabe, D., Yasuda, K., Kurose, T., Kawakita, T., Seino, Y, and Inagaki, N. Insulin secretory
capacity and insulin sensitivity in impaired fasting glucose in Japanese. J. Diabtes Invest. , in
press.
64. ○ Saito, M., Hayakawa, A., Inagaki, N., and Matsuoka, H. Development of novel cell lines of
diabetic dysfunction model fit for cell-based screening tests of medicinal materials.
Cytotechnology, in press.
65. Inagaki, N., Atsumi, Y., Oura, T., Saito, H., and Imaoka, T. Efficacy and safety of exenatide
once weekly compared with insulin once daily in Japanese patients with type 2 diabetes treated
with oral antidiabetic drug(s): a randomized, open-label, non-inferiority study. Clin. Ther., in
press.
13) Yo-ichi Nabeshima
86
1.
○ Yokoyama K, Imura A, Ohkido I, Maruyama Y, Yamazaki Y, Hasegawa H, Urae J, Sekino
H, Nabeshima Y, Hosoya T (2012) Serum soluble alpha-klotho in hemodialysis patients. Clin
Nephrol 77(5): 347-351
2.
Sugimoto R, Nabeshima Y, Yoshida S (2012) Retinoic acid metabolism links the periodical
differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium.
Mech Dev 128(11-12): 610-624
3.
○ Siahanidou T, Garatzioti M, Lazaropoulou C, Kourlaba G, Papassotiriou I, Kino T, Imura A,
Nabeshima YI, Chrousos G (2012) Plasma soluble alpha-Klotho protein levels in premature
and term neonates: Correlations with growth and metabolic parameters. Eur J Endocrinol
4.
○ Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi
Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y (2012) Decreased renal
alpha-Klotho expression in early diabetic nephropathy in humans and mice and its possible role
in urinary calcium excretion. Kidney Int 81(6): 539-547
5.
Ohkido I, Yokoyama K, Imura A, Utsunomiya Y, Hosoya T, Nabeshima Y (2011) Persistent
alpha-Klotho (a-Kl) expression in the parathyroid glands of patients with secondary
hyperparathyroidism. Nephrol Dial Transplant 25(3): 1007-1008; author reply 1008-1009
6.
Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T,
Imura A, Nabeshima Y, Yamazaki Y, Ozono K (2011) Circulating levels of soluble
alpha-Klotho are markedly elevated in human umbilical cord blood. J Clin Endocrinol Metab
96(6): E943-947
7.
Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita
T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T,
Hataya H, Ichikawa S, Imel EA, Econs MJ, Nabeshima Y (2010) Establishment of sandwich
ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho
levels in healthy subjects. Biochem Biophys Res Commun 398(3): 513-518
8.
Tomiyama K, Maeda R, Urakawa I, Yamazaki Y, Tanaka T, Ito S, Nabeshima Y, Tomita T,
Odori S, Hosoda K, Nakao K, Imura A (2010) Relevant use of Klotho in FGF19 subfamily
signaling system in vivo. Proc Natl Acad Sci U S A 107(4): 1666-1671
9.
Nakagawa T, Sharma M, Nabeshima Y, Braun RE, Yoshida S (2010) Functional hierarchy and
reversibility within the murine spermatogenic stem cell compartment. Science 328(5974):
62-67
87
10. Okuyama H, Yoshida T, Son A, Oka S, Wang D, Nakayama R, Masutani H, Nakamura H,
Nabeshima Y, Yodoi J (2009) Thioredoxin binding protein 2 modulates natural killer T
cell-dependent innate immunity in the liver: possible link to lipid metabolism. Antioxid Redox
Signal 11(10): 2585-2593
11. Nabeshima Y (2009) Discovery of alpha-Klotho unveiled new insights into calcium and
phosphate homeostasis. Proc Jpn Acad Ser B Phys Biol Sci 85(3): 125-141
12. Fujimori T, Kurotaki Y, Komatsu K, Nabeshima Y (2009) Morphological organization of the
mouse preimplantation embryo. Reprod Sci 16(2): 171-177
13. Nabeshima Y, Imura H (2008) alpha-Klotho: a regulator that integrates calcium homeostasis.
Am J Nephrol 28(3): 455-464
14. Nabeshima Y (2008) The discovery of alpha-Klotho and FGF23 unveiled new insight into
calcium and phosphate homeostasis. Cell Mol Life Sci 65(20): 3218-3230
15. Brownstein CA, Adler F, Nelson-Williams C, Iijima J, Li P, Imura A, Nabeshima Y,
Reyes-Mugica M, Carpenter TO, Lifton RP (2008) A translocation causing increased
alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl
Acad Sci U S A 105(9): 3455-3460
14) Kazuwa Nakao
Total: 78
2012
1. Himeno A, Satoh-Asahara N, Usui T, Wada H, Tochiya M, Kono S, Yamada-Goto N, Katsuura
G, Hasegawa K, Nakao K, Shimatsu A. Salivary cortisol levels are associated with outcomes of
weight reduction therapy in obese Japanese patients. Metabolism 61:255-261, 2012
2011
1. K. Mori, M. Mukoyama and K. Nakao. Commentary: PPAR-γ transcriptional activity is required
to combat doxorubicin-induced podocyte injury in mice. Kidney Int. 79 (12): 1274-1276, 2011.
2. ○ H. Yokoi, M. Kasahara, K. Mori, Y. Ogawa, T. Kuwabara, H. Imamaki, T. Kawanishi, K.
Koga, A. Ishii, H. Muramatsu, T. Muramatsu, A. Sugawara, M. Mukoyama and K. Nakao. The
pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal
fibrosis. Kidney Int. 81:160-169, 2011.
3. T. Maki, M. Ihara, Y. Fujita Y, T. Nambu, K. Miyashita, M. Yamada, K. Washida, K. Nishio, H.
88
Ito, H Harada, H. Yokoi, H. Arai, H. Itoh, K. Nakao, R. Takahashi, H. Tomimoto. Angiogenic
and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic
cerebral hypoperfusion in mice. Stroke 42:1122-1128, 2011.
4. M. Naito, J. Fujikura, K. Ebihara, F. Miyanaga, H. Yokoi, T. Kusakabe, Y. Yamamoto, C. Son,
M. Mukoyama, K. Hosoda, K. Nakao. Therapeutic impact of leptin on diabetes, diabetic
complications, and longevity in insulin-deficient diabetic mice. Diabetes 60: 2265-2273, 2011
5. Zhao M, Li Y, Wang J, Ebihara K, Rong X, Hosoda K, Tomita T, Nakao K. Azilsartan treatment
improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes Obes
Metab 13:1123-1129, 2011.
6. Yamada N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, Nakao K. Impaired CNS
leptin action is implicated in depression associated with obesity. Endocrinology. 2011
Jul;152(7):2634-43.
7. ○ H. Iwakura, H. Ariyasu, H. Hosoda, G. Yamada, K. Hosoda, K. Nakao, K. Kangawa, T.
Akamizu. Oxytocin and Dopamine Stimulate Ghrelin Secretion by the Ghrelin-Producing Cell
Line, MGN3-1 in Vitro. Endocrinology 152: 2619-2625, 2011.
8. Ogihara T, Fujimoto A, Ueshima K, Nakao K, Saruta T: Age-related differences in the effects of
antihypertensive therapy on left ventricular hypertrophy in high-risk patients with
hypertension-candesartan antihypertensive survival evaluation in Japan subanalysis. J Am
Geriatr Soc. 59:180-181, 2011
9. Nakao MY, Ueshima K, Teramukai S, Tanaka S, Yasuno S, Fujimoto A, Kawakami K, Nakao K:
Considering selection bias when developing a search strategy. Arch Intern Med 171: 471-472
2011
10. Matsuoka H, Ando K, Ueshima K, Babazono T, Kario K, Tanaka S, Nakao K, Fujita T: Design
and rationale of the Study of Assessment for Kidney function by Urinary microalbumin in
RAndomized (SAKURA) trial: Comparison of the antialbuminuric effects between L-/N-type
and L-type calcium channel blocker in hypertensive patients with diabetes and
microalbuminuria. Clin Exp Hypertens 33: 455-462, 2011
11. Sawata H, Ueshima K, Tsutani K: Changes in the environment surrounding Japanese large-scale
clinical trials for cardiovascular diseases. Trials 12: 96, 2011
12. Ueshima K, Oba K, Yasuno S, Fujimoto A, Tanaka S, Ogihara T, Saruta T, Nakao K: Adverse
effects of coronary risk factors on coronary events in Japanese high-risk hypertensive patients:
89
Primary and secondary prevention of ischemic heart disease in a subanalysis of the CASE-J
(Candesartan Antihypertensive Survival Evaluation in Japan) trial Circ J 75: 2411-2416, 2011
13. Ogihara T, Nakao K, Fukiyama K, Ueshima K, Oba K, Yasuno S, Fujimoto A, Sato T,
Matsuoka H, Saruta T, for the CASE-J Trial Group: Long-term effects of candesartan and
amlodipine on cardiovascular morbidity and mortality in Japanese high-risk hypertensive
patients: the Candesartan Antihypertensive Survival Evaluation in Japan Extension Study
(CASE-J Ex). Hypertens Res 34:1295-1301, 2011
14. Kuwahara K, Nakao K. New Molecular Mechanisms for Cardiovascular Disease:
Transcriptional Pathways and Novel Therapeutic Targets in Heart Failure. J Pharmacol Sci.
116: 337-342, 2011
15. Nishikimi T, Ikeda M, Takeda Y, Ishimitsu T, Shibasaki I, Fukuda H, Kinoshita H, Nakagawa
Y, Kuwahara K, Nakao K. The effect of glycosylation on plasma N-terminal proBNP-76 levels
in patients with heart or renal failure. Heart 98:152-61, 2011
16. Nishikimi T, Minamino N, Nakao K. Diverse molecular forms of plasma B-type natriuretic
peptide in heart failure. Curr Heart Fail Rep. 8: 140-146, 2011.
17. Nishikimi T, Kuwahara K, Nakao K. Current biochemistry molecular biology, and clinical
relevance of natriuretic peptides. J Cardiol, 57: 131-140, 2011
18. ○ Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada
M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R,
Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK. Induction and
enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem
cells with cyclesporin-A. PLoS One. 22;6(2):e16734, 2011
19. Hata L, Murakami M, Kuwahara K, Nakagawa Y, Kinoshita H, Usami S, Yasuno S, Fujiwara
M, Kuwabara Y, Minami T, Yamada Y, Yamada C, Nakao K, Ueshima K, Nishikimi T, Nakao
K. Zinc-finger protein 90 negatively relulates neuron-restrictive silencer factor-mediated
transcriptional repression of fetal cardiac genes. J Mol Cell Cardiol. 50: 972-981, 2011
20. Sonoyama T, Sone M, Miyashita K, Tamura N, Yamahara K, Park K, Oyamada N, Taura D,
Inuzuka M, Kojima K, Honda K, Fukunaga Y, Kanamoto N, Miura M, Yasoda A, Arai H, Itoh
H, Nakao K. Significance of Adrenocorticotropin Stimulation Test in the Diagnosis of an
Aldosterone-Producing Adenoma. J Clin Endocrinol Metab 96: 2771-2778, 2011.
21. Alan S. Maisel, Kazuwa Nakao, Piotr Ponikowski, W. Frank Peacock, Michihiro Yoshimura,
90
Toru Suzuki, Takayoshi Tsutamoto, Gerasimos S. Filippatos, Yoshihiko Saito, Yoshihiko
Seino, Naoto Minamino, Yasunobu Hirata, Masashi Mukoyama, Toshio Nishikimi and Ryozo
NagaiJapanese-Western Consensus Meeting on Biomarkers Executive Summary. International
Heart Journal 52: 253-265, 2011
2010
1. ○ Yamada G, Ariyasu H, Iwakura H, Hosoda H, Akamizu T, Nakao K, Kangawa K.
Generation of transgenic mice overexpressing a ghrelin analog. Endocrinology 151: 5935-40,
2010
2. Ueshima K, Yasuno S, Oba K, Fujimoto A, Mukoyama M, Ogihara T, Saruta T, Nakao K.
Impact of left ventricular hypertrophy on the time-course of renal function in hypertensive
patients - subanalysis of the CASE-J trial - Circ J. 2010, 74: 2132-8.
3. Yasoda A, Nakao K. Genetic basis for skeletal disease. CNP therapy for achondroplasia Clin
Calcium 20: 1212-8, 2010
4. Mori K, Mukoyama M, Nakao K. Searching for novel intercellular signal-transducing molecules
in the kidney and their clinical application. Clin Exp Nephrol 14: 523-7, 2010
5. ○ Rong X, Li Y, Ebihara K, Zhao M, Kusakabe T, Tomita T, Murray M, Nakao K. Irbesartan
treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky
(fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010, 160:
1796-807.
6. Ueshima K, Kobayashi N, Yamazaki T, Saitoh M, Nakamura M, Nakao K. Clinical significance
of awake oscillatory ventilation in patients with heart failure and effects of open-heart surgery.
Clin Cardiol. 2010, 33:E20-3.
7. Fujii T, Komatsu Y, Yasoda A, Kondo E, Yoshioka T, Nambu T, Kanamoto N, Miura M,
Tamura N, Arai H, Mukoyama M, Nakao K. Circulating C-type natriuretic peptide (CNP)
rescues chondrodysplastic CNP knockout mice from their impaired skeletal growth and early
death. Endocrinology. 2010, 151:4381-8.
8. Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, Minami T, Yamada Y, Fujiwara
M, Nakao K. Myocardin-related transcription factor A is a common mediator of mechanical
stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to
activation of brain natriuretic peptide gene expression. Mol Cell Biol. 2010, 30:4134-48.
9. Inuzuka M, Tamura N, Yamada N, Katsuura G, Oyamada N, Taura D, Sonoyama T, Fukunaga Y,
91
Ohinata K, Sone M, Nakao K. C-type natriuretic peptide as a new regulator of food intake and
energy expenditure. Endocrinology. 2010, 151:3633-42.
10. ○ Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka
M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K. Sirt1 plays an important role in
mediating greater functionality of human ES/iPS-derived vascular endothelial cells.
Atherosclerosis. 2010, 212:42-7.
11. ○ Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose
H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T,
Ueshima K, Nakao K. Inhibition of TRPC6 channel activity contributes to the antihypertrophic
effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Circ Res. 2010,
106:1849-60.
12. ○ Rong X, Li Y, Ebihara K, Zhao M, Naowaboot J, Kusakabe T, Kuwahara K, Murray M,
Nakao K. Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on
dietary-induced obesity, insulin resistance and fatty liver in mice. Diabetologia 53: 1727-1731,
2010.
13. Nakao K, Hirata M, Oba K, Yasuno S, Ueshima K, Fujimoto A, Ogihara T, Saruta T; CASE-J
Trial Group. Role of diabetes and obesity in outcomes of the candesartan antihypertensive
survival evaluation in Japan (CASE-J) trial. Hypertens Res. 2010, 33:600-6.
14. ○ Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K,
Nakao K, Kangawa K, Akamizu T. Establishment of a novel ghrelin-producing cell line.
Endocrinology. 2010, 151:2940-5.
15. Ogihara T, Fujimoto A, Nakao K, Saruta T. Effects of antihypertensive drugs in the prevention
of new-onset diabetes mellitus in patients with hypertension at high-risk of cardiovascular
events in relation to aging. J Am Geriatr Soc. 2010, 58:395-6.
16. ○ Ariyasu H, Iwakura H, Yamada G, Kanamoto N, Bando M, Kohno K, Sato T, Kojima M,
Nakao K, Kangawa K, Akamizu T. A postweaning reduction in circulating ghrelin temporarily
alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does
not affect somatic growth. Endocrinology. 2010, 151:1743-50.
17. Yasuno S, Ueshima K, Oba K, Fujimoto A, Hirata M, Ogihara T, Saruta T, Nakao K. Is pulse
pressure a predictor of new-onset diabetes in high-risk hypertensive patients?: a subanalysis of
the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial. Diabetes Care.
2010, 33:1122-7.
92
18. Yokoi H, Kasahara M, Mukoyama M, Mori K, Kuwahara K, Fujikura J, Arai Y, Saito Y,
Ogawa Y, Kuwabara T, Sugawara A, Nakao K. Podocyte-specific expression of
tamoxifen-inducible Cre recombinase in mice. Nephrol Dial Transplant. 2010, 25:2120-4.
19. ○ Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Horiuchi M, Murray M,
Nakao K. Vasodilator therapy with hydralazine induces angiotensin AT receptor-mediated
cardiomyocyte growth in mice lacking guanylyl cyclase-A. Br J Pharmacol. 2010,
159:1133-42.
20. ○ Yasue S, Masuzaki H, Okada S, Ishii T, Kozuka C, Tanaka T, Fujikura J, Ebihara K,
Hosoda K, Katsurada A, Ohashi N, Urushihara M, Kobori H, Morimoto N, Kawazoe T, Naitoh
M, Okada M, Sakaue H, Suzuki S, Nakao K. Adipose tissue-specific regulation of
angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte
hypertrophy. Am J Hypertens. 2010, 23:425-31.
21. ○ Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y,
Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H,
Ham M, Lee YS, Kim JB, Saito Y, Nakao K. Adipose tissue-specific dysregulation of
angiotensinogen by oxidative stress in obesity. Metabolism. 2010, 59:1241-51.
2009
1. M. Sone, H. Shibata, K. Homma, N. Tamura, J. Akahira, S. Hamada, M. Yahata, N. Fukui, H.
Itoh, H. Sasano, and K. Nakao. Close examination of steroidogenesis disorders in a DOC- and
progesterone-producing adrenocortical carcinoma. Endocrine 35: 25-33, 2009
2. Nakao K. Adiposcience and adipotoxicity. Nat Clin Pract Endocrinol Metab. 5: 63, 2009.
3. ○ T. Kuwabara, K. Mori, M. Mukoyama, M. Kasahara, H. Yokoi, Y. Saito, T. Yoshioka, Y.
Ogawa, H. Imamaki, T. Kusakabe, K. Ebihara, M. Omata, N. Satoh, A. Sugawara, J. Barasch,
and K. Nakao. Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to
glomeruli, proximal tubules, and distal nephrons. Kidney Int. 75: 285-294, 2009.
4. T. Kusakabe, H. Tanioka, K. Ebihara, M. Hirata, L. Miyamoto, F. Miyanaga, H. Hige, D. Aotani,
T. Fujisawa, H. Masuzaki, K. Hosoda, and K. Nakao. Beneficial effects of leptin on glycaemic
and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by
streptozotocin and a high-fat diet. Diabetologia 52: 675-683, 2009.
5. ○ A. Yasoda, H. Kitamura, T. Fujii, E. Kondo, N. Murao, M. Miura, N. Kanamoto, Y. Komatsu,
H. Arai, and K. Nakao. Systemic administration of C-type natriuretic peptide as a novel
93
therapeutic strategy for skeletal dysplasias. Endocrinology. 150: 3138-3144, 2009.
6. K. Nakao, A. Yasoda, K. Ebihara, K. Hosoda, and M. Mokoyama. Translational research of
novel hormones: lessons from animal models and rare human diseases for common human
diseases. J Mol Med. 87: 1029-1039, 2009.
7. ○ H. Iwakura , H. Ariyasu, Y. Li, N. Kanamoto, M. Bando, G. Yamada, H. Hosoda, K. Hosoda,
A. Shimatsu, K. Nakao, K. Kangawa, and T. Akamizu. A mouse model of ghrelinoma exhibited
activated growth hormone-insulin-like growth factor I axis and glucose intolerance. Am J
Physiol Endocrinol Metab. 297:E802-811, 2009.
8. H. Kinoshita, K. Kuwahara, M. Takano, Y. Arai, Y. Kuwabara, S. Yasuno, Y. Nakagawa, M.
Nakanishi, M. Harada, M. Fujiwara, M. Murakami, K. Ueshima, and K. Nakao. T-type Ca2+
channel blockade prevents sudden death in mice with heart failure. Circulation. 120:743-752,
2009.
9. S. Yasuno, S. Usami, K. Kuwahara, M. Nakanishi, Y. Arai, H. Kinoshita, Y. Nakagawa, M.
Fujiwara, M. Murakami, K. Ueshima, M. Harada, and K. Nakao. Endogenous cardiac natriuretic
peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death. Am J
Physiol Heart Circ Physiol. 296: H1804-1810, 2009.
10. ○ D. Taura, M. Noguchi, M. Sone, K. Hosoda, E. Mori, Y. Okada, K. Takahashi, K. Homma,
N. Oyamada, M. Inuzuka, T. Sonoyama, K. Ebihara, N. Tamura, H. Itoh, H. Suemori, N.
Nakatsuji, H. Okano, S. Yamanaka, and K. Nakao. Adipogenic differentiation of human
induced pluripotent stem cells: comparison with that of human embryonic stem cells. FEBS
Lett. 583: 1029-1033, 2009.
11. ○ D. Taura, M. Sone, K. Homma, N. Oyamada, K. Takahashi, N. Tamura, S. Yamanaka, and
K. Nakao. Induction and isolation of vascular cells from human induced pluripotent stem
cells--brief report. Arterioscler Thromb Vasc Biol. 29:1100-1103, 2009.
12. T. Sonoyama, N. Tamura, K. Miyashita, K. Park, N. Oyamada, D. Taura, M. Inuzuka, Y.
Fukunaga, M. Sone, and K. Nakao. Inhibition of hepatic damage and liver fibrosis by brain
natriuretic peptide. FEBS Lett. 583:2067-2070, 2009.
13. K. Miyashita, H. Itoh, H. Tsujimoto, N. Tamura, Y. Fukunaga, M. Sone, K. Yamahara, D.
Taura, M. Inuzuka, T. Sonoyama, and K. Nakao. Natriuretic peptides/cGMP/cGMP-dependent
protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity.
Diabetes. 58:2880-2892, 2009.
94
14. ○ N. Sawada, H. Itoh, K. Miyashita, H. Tsujimoto, M. Sone, K. Yamahara, ZP Arany, F.
Hofmann, and K. Nakao. Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate proand antifibrotic signals in blood vessels. Mol Cell Biol. 29:6018-6032, 2009.
15. ○ T. Kake, H. Kitamura, Y. Adachi, T. Yoshioka, T. Watanabe, H. Matsushita H, T. Fujii, E.
Kondo, T. Tachibe, Y. Kawase, KI Jishage, A. Yasoda, M. Mukoyama, and K. Nakao.
Chronically elevated plasma C-type natriuretic peptide (CNP) level stimulates skeletal growth
in transgenic mice. Am J Physiol Endocrinol Metab. 297: E1339-48, 2009.
16. Y. Nakagawa, K. Kuwahara, G. Takemura, M. Akao, M. Kato, Y. Arai, M. Takano, M. Harada,
M. Murakami, M. Nakanishi, S. Usami, S. Yasuno, H. Kinoshita, M. Fujiwara, K. Ueshima,
and K. Nakao. p300 plays a critical role in maintaining cardiac mitochondrial function and
cell survival in postnatal hearts. Circ. Res. 105: 746-754. 2009.
17. ○ Y. Li, Y. Saito, K. Kuwahara, X. Rong, I. Kishimoto, H. Harada, Y. Adachi, M. Nakanishi,
H. Kinoshita, M. Horiuchi, M. Murray, and K. Nakao. Natriuretic peptide receptor/guanylyl
cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the
heart. Endocrinology 150: 3759-3765. 2009.
18. ○ N. Yamada, N, G. Katsuura, I. Tatsuno, S. Kawahara, K. Ebihara, Y. Saito, and K. Nakao.
Orexin increase mRNA expressions of neurotrophin-3 in rat primary cortical neuron culture
neuron cultures. Neurosci.Lett. 450: 132-135. 2009.
2008
1. T. Ogihara, K. Nakao, T. Fukui, K. Fukiyama, K. Ueshima, K. Oba, T. Sato, T. Saruta, for the
CASE-J Trial Group. Effects of candesartan compared with amlodipine for treatment of
hypertensive patients with high cardiovascular risks in CASE-J trial. Hypertension 51: 393-398,
2008
2. H. Yokoi, M. Mukoyama, K. Mori, M. Kasahara, T. Suganami, K. Sawai, T. Yoshioka, Y. Saito,
Y. Ogawa, T. Kuwabara, A. Sugawara, and K. Nakao. Overexpression of connective tissue
growth factor in podocytes worsens diabetic nephropathy in mice. Kidney Int. 73: 446-455,
2008.
3. ○ K. Hotta, Y. Nakata, T. Matsuo, S. Komohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J.
Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto, T.
Funahashi, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T.
Sakata, Y. Matsuzawa, K. Tanaka, N. Kamatani, and Y. Nakamura. Variations in the FTO gene
are associated with severe obesity in the Japanese. J. Hum. Genet. 53: 546-553, 2008.
95
4. ○ S. Usami, I. Kishimoto, Y. Saito, M. Harada, K. Kuwahara, Y. Nakagawa, M. Nakanishi, S.
Yasuno, K. Kangawa, and K. Nakao. Association of CT dinucleotide repeat polymorphism in the
5’-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the
Japanese. Hypertens. Res. 31: 89-96, 2008.
5. ○ H. Ariyasu, H. Iwakura, G. Yamada, K. Nakao, K. Kangawa, and T. Akamizu. Efficacy of
ghrelin as a therapeutic approach for age-related physiological changes. Endocrinology 149:
3722-3728, 2008.
6. H. Arai, N. Kobayashi, Y. Nakatsuru, H. Masuzaki, T. Nambu, K. Tanaka, Y. Yamanaka, E.
Kondo, G. Yamada, T. Fujii, M. Miura, Y. Komatsu, N. Kanemoto, H. Ariyasu, K. Moriyama, A.
Yasoda, and K. Nakao. A case of cortisol producing adrenal adenoma without phenotype of
cusing’s syndrome due to impaired 11β-hydroxysteroid dehydrogenase 1 activity. Endocr. J. 55:
709-715, 2008.
7. ○ T. Tokudome, I. Kishimoto, T. Horio, Y. Arai, D-O Schwenke, J. Hino, I. Okano, Y.
Kawano, M. Kohno, M. Miyazato, K. Nakao, and K. Kangawa. Regulator of G-protein signaling
subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
Circulation 117: 2329-2339, 2008.
8. ○ K. Hotta, M. Kanamura, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, R. Komatsu, N.
Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M.
Kawamoto, T. Funahashi, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu,
K. Nakao, T. Sakata, Y. Matsuzawa, K. Tanaka, N. Kamatani, and Y. Nakamura. INSIG2 gene
rs7566605 polymorphism is associated with severe obesity in Japanese. J. Hum. Genet.
53:0857-862, 2008
9. T. Ogihara, K. Nakao, T. Fukui, K. Fukiyama, A. Fujimoto, K. Ueshima, K. Oba, K. Shimamoto,
H. Matsuoka, and T. Saruta, for the CASE-J Traial Group. The optimal target blood pressure for
antihypertensive treatment in Japanese elderly patients with high-risk hypertension: a
subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial.
Hypertens. Res. 31: 1595-1601, 2008.
10. M. Yamamuro, M. Yoshimura, M. Nakayama, K. Abe, H. Sumida, S. Sugiyama, Y. Saito, K.
Nakao, H. Yasue, and H. Ogawa. Aldosterone, but not angiotensin II, reduces angiotensin
converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes. Circ. J.
72: 1346-1350, 2008
11. T. Nagae, K. Mori, M. Mukoyama, M. Kasahara, H. Yokoi, T. Suganami, K. Sawai, T.
Yoshioka, M. Koshikawa, Y. Saito, Y. Ogawa, T. Kuwabara, I. Tanaka, A. Sugawara, T.
96
Kuwahara, and K. Nakao. Adrenomedullin inhibits connective tissue growth factor expression,
extracellular signal-regulated kinase activation and renal fibrosis. Kidney Int. 74: 70-80, 2008.
12. N. Oyamada, M. Sone, K. Miyashita, K. Park, D. Taura, M. Inuzuka, T. Sonoyama, H.
Tsujimoto, Y. Fukunaga, N. Tamura, H. Itoh, and K. Nakao. The role of mineralocorticoid
receptor expression in brain remodeling after cerebral ischemia. Endocrinology 149: 3764-3777,
2008.
13. ○ Y. Hotta, S. Sasaki, M. Konishi, H. Kinoshita, K. Kuwahara, K. Nakao, and N. Itoh. Fgf16
is required for cardiomyocyte proliferation in the mouse embryonic heart. Dev Dyn.
237:2947-2954, 2008.
14. K. Park, H. Itoh, K. Yamahara, M. Sone, K. Miyashita, N. Oyamada, N. Sawada, D. Taura, M.
Inuzuka, T. Sonoyama, H. Tsujimoto, Y. Fukunaga, N. Tamura, and K. Nakao. Therapeutic
potential of atrial nariuretic peptide administration on peripheral arterial diseases.
Endorcinology 149: 483-491, 2008.
15. ○ K. Yamahara, M. Sone, H. Itoh, J. K. Yamashita, T. Yurugi-Kobayashi, K. Homma, T.-H.
Chao, K. Miyashita, K. Park, N. Oyamada, N. Sawada, D. Taura, Y. Fukunaga, N. Tamura, and
K. Nakao. Augmentation of neovascularizaiton in hindlimb ischemia by combined
transplantation of human embryonic stem cells-derived endothelial and mural cells. PLoS ONE
3: e1666, 2008
16. N. Oyamada, H. Itoh, M. Sone, K. Yamahara, K. Miyashita, K. Park, D. Taura, M. Inuzuka, T.
Sonoyama, H. Tsujimoto, Y. Fukunaga, N. Tamura, and K. Nakao. Transplantation of vascular
cells derived from human embryonic stem cells contributes to vascular regeneration after stroke
in mice. J. Transl. Med. 6: 54, 2008.
17. K. Ueshima, K. Oba, S. Yasuno, A. Fujimoto, T. Sato, K. Fukiyama, J. Azuma, T. Ogihara, T.
Saruta, K. Nakao; Candesartan Antihypertensive Survival Evaluation in Japan Trial Group.
Long-term effects of candesartan and amlodipine on cardiovascular mortality and morbidity in
Japanese high-risk hypertensive patients: rationale, design, and characteristics of candesartan
antihypertensive survival evaluation in Japan extension (CASE-J Ex). Contemp Clin Trials. 30:
97-101, 2008.
15) Toru Kita
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Tokushige A, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Iwabuchi M,
Shizuta S, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Ehara N, Inada T, Kaburagi S,
Hamasaki S, Tei C, Nakashima H, Ogawa H, Tatami R, Suwa S, Takizawa A, Nohara R,
Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T (2012) Incidence and outcome of
surgical procedures after coronary bare-metal and drug-eluting stent implantation: a report from
the CREDO-Kyoto PCI/CABG registry cohort-2. Circ Cardiovasc Interv 5(2): 237-246
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Tada T, Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Byrne RA, Kastrati A, Kadota K,
Iwabuchi M, Shizuta S, Tazaki J, Shiomi H, Abe M, Ehara N, Mizoguchi T, Mitsuoka H, Inada
T, Araki M, Kaburagi S, Taniguchi R, Eizawa H, Nakano A, Suwa S, Takizawa A, Nohara R,
Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T, Kimura T (2012) Duration of dual antiplatelet
therapy and long-term clinical outcome after coronary drug-eluting stent implantation:
landmark analyses from the CREDO-Kyoto PCI/CABG Registry Cohort-2. Circ Cardiovasc
Interv 5(3): 381-391
4.
Shizuta S, Ando K, Nobuyoshi M, Ikeda T, Yoshino H, Hiramatsu S, Kazatani Y, Yamashiro K,
Okajima K, Kajiya T, Kobayashi Y, Kato T, Fujii S, Mitsudo K, Inoue K, Ito H, Haruna Y, Doi
T, Nishio Y, Ozasa N, Nishiyama K, Kita T, Morimoto T, Kimura T (2012) Prognostic utility
of T-wave alternans in a real-world population of patients with left ventricular dysfunction: the
PREVENT-SCD study. Clin Res Cardiol 101(2): 89-99
5.
Shiomi H, Morimoto T, Hayano M, Furukawa Y, Nakagawa Y, Tazaki J, Imai M, Yamaji K,
Tada T, Natsuaki M, Saijo S, Funakoshi S, Nagao K, Hanazawa K, Ehara N, Kadota K,
Iwabuchi M, Shizuta S, Abe M, Sakata R, Okabayashi H, Hanyu M, Yamazaki F, Shimamoto
M, Nishiwaki N, Imoto Y, Komiya T, Horie M, Fujiwara H, Mitsudo K, Nobuyoshi M, Kita T,
Kimura T (2012) Comparison of Long-Term Outcome After Percutaneous Coronary
Intervention Versus Coronary Artery Bypass Grafting in Patients With Unprotected Left Main
Coronary Artery Disease (from the CREDO-Kyoto PCI/CABG Registry Cohort-2). Am J
Cardiol
6.
Niizuma S, Inuzuka Y, Okuda J, Kato T, Kawashima T, Tamaki Y, Iwanaga Y, Yoshida Y,
Kosugi R, Watanabe-Maeda K, Machida Y, Tsuji S, Aburatani H, Izumi T, Kita T, Kimura T,
Shioi T (2012) Effect of persistent activation of phosphoinositide 3-kinase on heart. Life Sci
90(15-16): 619-628
7.
Natsuaki M, Nakagawa Y, Morimoto T, Ono K, Shizuta S, Furukawa Y, Kadota K, Iwabuchi
M, Kato Y, Suwa S, Inada T, Doi O, Takizawa A, Nobuyoshi M, Kita T, Kimura T (2012)
98
Impact of statin therapy on late target lesion revascularization after sirolimus-eluting stent
implantation (from the CREDO-Kyoto Registry Cohort-2). Am J Cardiol 109(10): 1387-1396
8.
Natsuaki M, Furukawa Y, Morimoto T, Nakagawa Y, Ono K, Kaburagi S, Inada T, Mitsuoka H,
Taniguchi R, Nakano A, Kita T, Sakata R, Kimura T (2012) Intensity of Statin Therapy,
Achieved Low-Density Lipoprotein Cholesterol Levels and Cardiovascular Outcomes in
Japanese Patients After Coronary Revascularization. Circ J 76(6): 1369-1379
9.
Nakao T, Kimura T, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Nobuyoshi M, Kita T,
Mitsudo K (2012) The long-term efficacy of cilostazol in addition to dual antiplatelet therapy
after sirolimus-eluting stent implantation for Japanese patients: an analysis of the 3-year
follow-up outcomes from the j-Cypher registry. Cardiovasc Interv Ther
10. Miyata H, Uno K, Ono T, Yashiro M, Fukatsu A, Kita T, Kimura T, Muso E (2012) Low
density lipoprotein apheresis ameliorates interferon-gamma production in patients with
nephrotic syndrome. Ther Apher Dial 16(2): 189-194
11. Marui A, Kimura T, Tanaka S, Furukawa Y, Kita T, Sakata R (2012) Significance of off-pump
coronary artery bypass grafting compared with percutaneous coronary intervention: a
propensity score analysis. Eur J Cardiothorac Surg 41(1): 94-101
12. Kawashima T, Inuzuka Y, Okuda J, Kato T, Niizuma S, Tamaki Y, Iwanaga Y, Kawamoto A,
Narazaki M, Matsuda T, Adachi S, Takemura G, Kita T, Kimura T, Shioi T (2012) Constitutive
SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice. J Mol Cell
Cardiol 51(6): 1026-1036
13. Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Kawamoto A, Tamaki Y, Iwanaga Y,
Soga T, Kita T, Kimura T, Shioi T (2012) Analysis of liver metabolism in a rat model of heart
failure. Int J Cardiol
14. Iguchi M, Kato M, Nakai J, Takeda T, Matsumoto-Ida M, Kita T, Kimura T, Akao M (2012)
Direct monitoring of mitochondrial calcium levels in cultured cardiac myocytes using a novel
fluorescent indicator protein, GCaMP2-mt. Int J Cardiol 158(2): 225-234
15. Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki
Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T
(2011) MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting
thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. Mol Cell B iol 31(4):
744-755
99
16. Marui A, Kimura T, Tanaka S, Miwa S, Yamazaki K, Minakata K, Nakata T, Ikeda T,
Furukawa Y, Kita T, Sakata R (2011) Coronary revascularization in patients with liver cirrhosis.
Ann Thorac Surg 91(5): 1393-1399
17. Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Kinoshita M, Watanabe S, Baba O, Kojima
Y, Shizuta S, Imai M, Tamura T, Kita T, Kimura T (2011) Increased microRNA-1 and
microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial
damage. Circ Cardiovasc Genet 4(4): 446-454
18. Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A,
Kita T, Hasegawa K (2010) Aldosterone signaling associates with p300/GATA4 transcriptional
pathway during the hypertrophic response of cardiomyocytes. Circ J 74(1): 156-162
19. Watanabe S, Tamura T, Ono K, Horiuchi H, Kimura T, Kita T, Furukawa Y (2010) Insulin-like
growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as
a prognostic predictor of heart failure: association with adiponectin. Eur J Heart Fail 12(11):
1214-1222
20. Nishiyama K, Morimoto T, Furukawa Y, Nakagawa Y, Ehara N, Taniguchi R, Ozasa N, Saito
N, Hoshino K, Touma M, Tamura T, Haruna Y, Shizuta S, Doi T, Fukushima M, Kita T,
Kimura T (2010) Chronic obstructive pulmonary disease--an independent risk factor for
long-term cardiac and cardiovascular mortality in patients with ischemic heart disease. Int J
Cardiol 143(2): 178-183
21. Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Mori
RT, Hasegawa K, Kita T, Kimura T (2010) MicroRNA-15b modulates cellular ATP levels and
degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes. J Biol Chem 285(7):
4920-4930
22. Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara
Y, Hasegawa K, Kita T, Kimura T (2010) Neural cell adhesion molecule is a cardioprotective
factor up-regulated by metabolic stress. J Mol Cell Cardiol 48(6): 1157-1168
23. Kume N, Mitsuoka H, Hayashida K, Tanaka M, Kominami G, Kita T (2010) Soluble lectin-like
oxidized LDL receptor-1 (sLOX-1) as a sensitive and specific biomarker for acute coronary
syndrome--comparison with other biomarkers. J Cardiol 56(2): 159-165
24. Kume N, Mitsuoka H, Hayashida K, Tanaka M, Kita T (2010) Soluble lectin-like oxidized
low-density lipoprotein receptor-1 predicts prognosis after acute coronary syndrome--a pilot
study. Circ J 74(7): 1399-1404
100
25. Kinoshita M, Ono K, Horie T, Nagao K, Nishi H, Kuwabara Y, Takanabe-Mori R, Hasegawa
K, Kita T, Kimura T (2010) Regulation of adipocyte differentiation by activation of serotonin
(5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated
repression of KLF5. Mol Endocrinol 24(10): 1978-1987
26. Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Tamaki Y, Iwanaga Y, Narazaki M,
Matsuda T, Soga T, Kita T, Kimura T, Shioi T (2010) Analysis of metabolic remodeling in
compensated left ventricular hypertrophy and heart failure. Circ Heart Fail 3(3): 420-430
27. Ikeda T, Taniguchi R, Watanabe S, Kawato M, Kondo H, Shirakawa R, Yamane K, Toma M,
Tamura T, Takahashi K, Watanabe H, Yoshikawa Y, Tabuchi A, Kita T, Kimura T, Horiuchi H
(2010) Characterization of the antiplatelet effect of aspirin at enrollment and after 2-year
follow-up in a real clinical setting in Japan. Circ J 74(6): 1227-1235
28. Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y,
Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T (2010) Acute doxorubicin
cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway.
Cardiovasc Res 87(4): 656-664
29. Higashi T, Ikeda T, Murakami T, Shirakawa R, Kawato M, Okawa K, Furuse M, Kimura T,
Kita T, Horiuchi H (2010) Flightless-I (Fli-I) regulates the actin assembly activity of
diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.
J Biol Chem 285(21): 16231-16238
30. Shirakawa R, Fukai S, Kawato M, Higashi T, Kondo H, Ikeda T, Nakayama E, Okawa K,
Nureki O, Kimura T, Kita T, Horiuchi H (2009) Tuberous sclerosis tumor suppressor
complex-like complexes act as GTPase-activating proteins for Ral GTPases. J Biol Chem
284(32): 21580-21588
31. Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K,
Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T, Horie M (2009) Novel
KCNE3 mutation reduces repolarizing potassium current and associated with long QT
syndrome. Hum Mutat 30(4): 557-563
32. Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, Oshima N, Kiyonari H,
Kimura T, Kita T, Nishi E (2009) Nardilysin regulates axonal maturation and myelination in
the central and peripheral nervous system. Nat Neurosci 12(12): 1506-1513
33. Oga T, Chin K, Tabuchi A, Kawato M, Morimoto T, Takahashi K, Handa T, Taniguchi R,
101
Kondo H, Mishima M, Kita T, Horiuchi H (2009) Effects of obstructive sleep apnea with
intermittent hypoxia on platelet aggregability. J Atheroscler Thromb 16(6): 862-869
34. Nishiyama K, Horiguchi M, Shizuta S, Doi T, Ehara N, Tanuguchi R, Haruna Y, Nakagawa Y,
Furukawa Y, Fukushima M, Kita T, Kimura T (2009) Temporal pattern of strokes after
on-pump and off-pump coronary artery bypass graft surgery. Ann Thorac Surg 87(6):
1839-1844
35. Nishio Y, Makiyama T, Itoh H, Sakaguchi T, Ohno S, Gong YZ, Yamamoto S, Ozawa T, Ding
WG, Toyoda F, Kawamura M, Akao M, Matsuura H, Kimura T, Kita T, Horie M (2009) D85N,
a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome. J Am Coll
Cardiol 54(9): 812-819
36. Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Tanaka M, Kimura T (2009) The search
for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with
Nkx2-5 gene targeting. Biochem Biophys Res Commun 390(3): 821-826
37. Mitsuoka H, Toyohara M, Kume N, Hayashida K, Jinnai T, Tanaka M, Kita T (2009)
Circulating soluble SR-PSOX/CXCL16 as a biomarker for acute coronary syndrome
-comparison with high-sensitivity C-reactive protein. J Atheroscler Thromb 16(5): 586-593
38. Mitsuoka H, Kume N, Hayashida K, Inui-Hayashiada A, Aramaki Y, Toyohara M, Jinnai T,
Nishi E, Kita T (2009) Interleukin 18 stimulates release of soluble lectin-like oxidized LDL
receptor-1 (sLOX-1). Atherosclerosis 202(1): 176-182
39. Kojima Y, Ono K, Inoue K, Takagi Y, Kikuta K, Nishimura M, Yoshida Y, Nakashima Y,
Matsumae H, Furukawa Y, Mikuni N, Nobuyoshi M, Kimura T, Kita T, Tanaka M (2009)
Progranulin expression in advanced human atherosclerotic plaque. Atherosclerosis 206(1):
102-108
40. Kimura T, Morimoto T, Nakagawa Y, Tamura T, Kadota K, Yasumoto H, Nishikawa H, Hiasa
Y, Muramatsu T, Meguro T, Inoue N, Honda H, Hayashi Y, Miyazaki S, Oshima S, Honda T,
Shiode N, Namura M, Sone T, Nobuyoshi M, Kita T, Mitsudo K (2009) Antiplatelet therapy
and stent thrombosis after sirolimus-eluting stent implantation. Circulation 119(7): 987-995
41. Kato M, Akao M, Matsumoto-Ida M, Makiyama T, Iguchi M, Takeda T, Shimizu S, Kita T
(2009) The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence
from two-photon imaging. Cardiovasc Res 83(2): 335-344
42. Jinnai T, Horiuchi H, Makiyama T, Tazaki J, Tada T, Akao M, Ono K, Hoshino K, Naruse Y,
102
Takahashi K, Watanabe H, Kita T, Kimura T (2009) Impact of CYP2C19 polymorphisms on
the antiplatelet effect of clopidogrel in an actual clinical setting in Japan. Circ J 73(8):
1498-1503
43. Inuzuka Y, Okuda J, Kawashima T, Kato T, Niizuma S, Tamaki Y, Iwanaga Y, Yoshida Y,
Kosugi R, Watanabe-Maeda K, Machida Y, Tsuji S, Aburatani H, Izumi T, Kita T, Shioi T
(2009) Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice. Circulation
120(17): 1695-1703
44. Hoshino K, Horiuchi H, Tada T, Tazaki J, Nishi E, Kawato M, Ikeda T, Yamamoto H, Akao M,
Furukawa Y, Shizuta S, Toma M, Tamura T, Saito N, Doi T, Ozasa N, Jinnai T, Takahashi K,
Watanabe H, Yoshikawa Y, Nishimoto N, Ouchi C, Morimoto T, Kita T, Kimura T (2009)
Clopidogrel resistance in Japanese patients scheduled for percutaneous coronary intervention.
Circ J 73(2): 336-342
45. Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K,
Akama TO, Kita T, Kimura T, Nakamura T (2009) Fibulin-4 conducts proper elastogenesis via
interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A
106(45):
19029-19034
46. Horie T, Ono K, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Takanabe R,
Hasegawa K, Kita T, Kimura T (2009) MicroRNA-133 regulates the expression of GLUT4 by
targeting KLF15 and is involved in metabolic control in cardiac myocytes. Biochem Biophys
Res Commun 389(2): 315-320
47. Yamamoto H, Takahashi K, Watanabe H, Yoshikawa Y, Shirakawa R, Higashi T, Kawato M,
Ikeda T, Tabuchi A, Morimoto T, Kita T, Horiuchi H (2008) Evaluation of the antiplatelet
effects of cilostazol, a phosphodiesterase 3 inhibitor, by VASP phosphorylation and platelet
aggregation. Circ J 72(11): 1844-1851
48. Yamamoto H, Kawada T, Kamiya A, Kita T, Sugimachi M (2008) Electroacupuncture changes
the relationship between cardiac and renal sympathetic nerve activities in anesthetized cats.
Auton Neurosci 144(1-2): 43-49
49. Wu YW, Tadamura E, Kanao S, Yamamuro M, Okayama S, Ozasa N, Toma M, Kimura T,
Kita T, Marui A, Komeda M, Togashi K (2008) Left ventricular functional analysis using
64-slice multidetector row computed tomography: comparison with left ventriculography and
cardiovascular magnetic resonance. Cardiology 109(2): 135-142
50. Ozasa N, Furukawa Y, Morimoto T, Tadamura E, Kita T, Kimura T (2008) Relation among left
103
ventricular mass, insulin resistance, and hemodynamic parameters in type 2 diabetes.
Hypertens Res 31(3): 425-432
51. Ohno S, Kubota T, Yoshida H, Tsuji K, Makiyama T, Yamada S, Kuga K, Yamaguchi I, Kita T,
Horie M (2008) A novel mutation associated with Jervell and Lange-Nielsen syndrome in a
Japanese family. Circ J 72(5): 687-693
52. Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y, Nakashima Y, Kojima Y,
Nobuyoshi M, Kita T, Tanaka M (2008) CCN1 knockdown suppresses neointimal hyperplasia
in a rat artery balloon injury model. Arterioscler Thromb Vasc Biol 28(6): 1077-1083
53. Makiyama T, Akao M, Shizuta S, Doi T, Nishiyama K, Oka Y, Ohno S, Nishio Y, Tsuji K, Itoh
H, Kimura T, Kita T, Horie M (2008) A novel SCN5A gain-of-function mutation M1875T
associated with familial atrial fibrillation. J Am Coll Cardiol 52(16): 1326-1334
54. Makiyama T, Akao M, Haruna Y, Tsuji K, Doi T, Ohno S, Nishio Y, Kita T, Horie M (2008)
Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese
patients with Brugada syndrome. Circ J 72(10): 1705-1706
55. Komori H, Arai H, Kashima T, Huby T, Kita T, Ueda Y (2008) Coexpression of CLA-1 and
human PDZK1 in murine liver modulates HDL cholesterol metabolism. Arterioscler Thromb
Vasc Biol 28(7): 1298-1303
56. Kimura T, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Ehara N, Taniguchi R, Doi T,
Nishiyama K, Ozasa N, Saito N, Hoshino K, Mitsuoka H, Abe M, Toma M, Tamura T, Haruna
Y, Imai Y, Teramukai S, Fukushima M, Kita T (2008) Long-term outcomes of coronary-artery
bypass graft surgery versus percutaneous coronary intervention for multivessel coronary artery
disease in the bare-metal stent era. Circulation 118(14 Suppl): S199-209
57. Kawato M, Shirakawa R, Kondo H, Higashi T, Ikeda T, Okawa K, Fukai S, Nureki O, Kita T,
Horiuchi H (2008) Regulation of platelet dense granule secretion by the Ral GTPase-exocyst
pathway. J Biol Chem 283(1): 166-174
58. Imai M, Kimura T, Toma M, Saito N, Nakanoue T, Tadamura E, Kita T, Inoue K (2008) Inoue
Stent-Graft Implantation for Thoracoabdominal Aortic Aneurysm Involving the Visceral
Arteries. Eur J Vasc Endovasc Surg 35(4): 462-465
59. Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu A, Kita T,
Hasegawa K (2008) Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt
and dual AMPK kinase in cardiac myocytes. J Cell Physiol 215(3): 733-742
104
60. Horie T, Ono K, Kinoshita M, Nishi H, Nagao K, Kawamura T, Abe Y, Wada H, Shimatsu A,
Kita T, Hasegawa K (2008) TG-interacting factor is required for the differentiation of
preadipocytes. J Lipid Res 49(6): 1224-1234
61. Hiraoka Y, Yoshida K, Ohno M, Matsuoka T, Kita T, Nishi E (2008) Ectodomain shedding of
TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Biochem Biophys Res
Commun 370(1): 154-158
62. Higashi T, Ikeda T, Shirakawa R, Kondo H, Kawato M, Horiguchi M, Okuda T, Okawa K,
Fukai S, Nureki O, Kita T, Horiuchi H (2008) Biochemical characterization of the Rho
GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in
platelets. J Biol Chem 283(13): 8746-8755
16) Masayuki Yokode
1.
Morimoto N, Yoshimura K, Niimi M, Ito T, Tada H, Teramukai S, Murayama T, Toyooka C,
Takemoto S, Kawai K, Yokode M, Shimizu A, Suzuki S(2012) An exploratory clinical trial for
combination wound therapy with a novel medical matrix and fibroblast growth factor in
patients with chronic skin ulcers: a study protocol. Am J Transl Res. 4(1): 52-59.
2.
Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Nishio Y, Sasaki K, Itoh H,
Yokode M, Kita T, Horie M, Kimura T (2012) A novel gain-of-function KCNJ2 mutation
associated with short-QT syndrome impairs inward rectification of Kir2.1 currents. Cardiovasc
Res. 93(4): 666-673.
3.
Tamura Y, Murayama T, Minami M, Matsubara T, Yokode M, Arai H (2012) Ezetimibe
Ameliorates Early Diabetic Nephropathy in db/db Mice. J Atheroscler Thromb 19(7): 608-618.
4.
Shimada K, Murayama T, Yokode M, Kita T, Fujita M, Kishimoto C (2011) Olmesartan, a
novel angiotensin II type 1 receptor antagonist, reduces severity of atherosclerosis in
apolipoprotein E deficient mice associated with reducing superoxide production. Nutr Metab
Cardiovasc Dis. 21(9): 672-678
5.
Shimada K, Mikami Y, Murayama T, Yokode M, Fujita M, Kita T, Kishimoto C (2011)
Atherosclerotic plaques induced by marble-burying behavior are stabilized by exercise training
in experimental atherosclerosis. Int J Cardiol. 151(3): 284-289.
6.
Ido A, Moriuchi A, Numata M, Murayama T, Teramukai S, Marusawa H, Yamaji N, Setoyama
H, Kim ID, Chiba T, Higuchi S, Yokode M, Fukushima M, Shimizu A, Tsubouchi H (2011)
105
Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in
patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to
ensure safety. J Transl Med. 9: 55.
7.
Tamura Y, Murayama T, Minami M, Yokode M, Arai H (2011) Differential effect of statins on
diabetic nephropathy in db/db mice. Int J Mol Med. 28(5): 683-687.
8.
Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R,
Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa
K(2011) Distinct characteristics of circulating vascular endothelial growth factor-a and C levels
in human subjects. PLoS One. 6(12):e29351.
9.
Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y,
Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T (2010) MicroRNA-33
encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in
vivo. ProcNatlAcadSci U S A. 107(40):17321-17326
10. Tamura Y, Sugimoto M, Murayama T, Minami M, Nishikaze Y, Ariyasu H, Akamizu T, Kita T,
Yokode M, Arai H (2010) C-C chemokine receptor 2 inhibitor improves diet-induced
development of insulin resistance and hepatic steatosis in mice. J Atheroscler Thromb
17(3):219-228.
11. Sugimoto M, Arai H, Tamura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H,
Akamizu T, Ueda Y, Kita T, Harada S, Kamei K, Yokode M (2009) Mulberry leaf ameliorates
the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in
db/db mice. Atherosclerosis 204: 388-394.
12. Shimada K, Murayama T, Yokode M, Kita T, Uzui H, Ueda T, Lee JD, Kishimoto C (2009)
N-Acetylcysteine reduces the severity of atherosclerosis in apolipoprotein E-deficient mice by
reducing superoxide production. Circ J 73: 1337-1341.
13. Tamura Y, Sugimoto M, Murayama T, Minami M, Nishikaze Y, Ariyasu H, Akamizu T, Kita T,
Yokode M, Arai H (2009) C-C Chemokine receptor 2 inhibitor improves diet-induced
development of insulin resistance and hepatic steatosis in mice. J Arterios cler Thromb 17:
219-228.
14. Akamizu T, Iwakura H, Ariyasu H, Hosoda H, Murayama T, Yokode M, Teramukai S, Seno H,
Chiba T, Noma S, Nakai Y, Fukunaga M, Nakai Y, Kangawa K, FD Clinical Study Team
(2008) Repeated administration of ghrelin to patients with functional dyspepsia: its effects on
food intake and appetite. Eur J Endocrinol 158: 491-498.
106
15. Tamura Y, Sugimoto M, Murayama T, Ueda Y, Kanamori H, Ono K, Ariyasu H, Akamizu T,
Kita T, Yokode M, Arai H (2008) Inhibition of CCR2 ameliorates insulin resistance and
hepatic steatosis in db/db mice. Arterioscler Thromb Vasc Biol 28: 2195-2201.
17) Motoko Yanagita
1 Physical finding of nutcracker phenomenon. Takeshi Matsubara, Osamu Ogawa, Motoko
Yanagita, Kidney International in press.
2
Inhibitors/antagonists of the TGF-ß system in kidney fibrosis. Motoko Yanagita, Nephrol Dial
Transpl in press.
3
Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenitalorgan aplasia: a
new mouse model of sirenomelia. Kentaro Suzuki, Yasuha Adachi, Tomokazu Numata, Shoko
Nakada, Motoko Yanagita, Naomi Nakagata, Sylvia M. Evans, Daniel Graf, Aris Economides,
Ryuma Haraguchi, Anne M. Moon, Gen Yamada. Plos One in press.
4
Bmp modulators in kidney disease. Nakamura J, Yanagita M. Discov Med. 2012
Jan;13(68):57-63.
5
Comparison of the psychosocial quality of life in hemodialysis patients between the elderly and
non-elderly using a visual analogue scale: the importance of appetite and depressive mood.
Kanamori H, Nagai K, Matsubara T, Mima A, Yanagita M, Iehara N, Takechi H, Fujimaki K,
Usami K, Fukatsu A, Kita T, Matsubayashi K, Arai H. Geriatr Gerontol Int. 2012
Jan;12(1):65-71.
6
Nariaki Asada, Masayuki Takase, Jin Nakamura, Akiko Oguchi, Misako Asada, Norio Suzuki,
Ken-ichi Yamamura, Narihito Nagoshi, Shinsuke Shibata, Tata Nageswara Rao, Hans Joerg
Fehling, Atsushi Fukatsu, Naoko Minegishi, Toru Kita, Takeshi Kimura, Hideyuki Okano,
Masayuki Yamamoto, and Motoko Yanagita. Dysfunction of fibroblasts of extra-renal origin
underlies renal fibrosis and renal anemia in mice. J Clin Invest. 121(10):3981-90, 2011
7
Mari Tanaka, Misako Asada, Atsuko Y Higashi, Jin Nakamura, Akiko Oguchi, Mayumi
Tomita, Sachiko Yamada, Nariaki Asada, Masayuki Takase, Tomohiko Okuda, Hiroshi
Kawachi, Aris N. Economides, Elizabeth Robertson, Satoru Takahashi, Takeshi Sakurai, Roel
Goldschmeding, Eri Muso, Atsushi Fukatsu, Toru Kita, and Motoko Yanagita. Loss of the
BMP antagonist, USAG-1 ameliorates disease in a mouse model of progressive hereditary
kidney disease Alport syndrome. J Clin Invest. 120 (3):768-77, 2010
107
8
Motoko Yanagita. BMP antagonists in kidney diseases. Curr Opin Invest Drugs 11(3):315-22,
2010.
9
Atsuko Y. Higashi, Tomokatsu Ikawa, Masamichi Muramatsu, Aris N. Economides, Akira
Niwa, Tomohiko Okuda, Andrew J. Murphy, Jose Rojas, Toshio Heike, Tatsutoshi Nakahata,
Hiroshi Kawamoto, Toru Kita, and Motoko Yanagita. Direct hematological toxicity and
illegitimate chromosomal recombination caused by the systemic activation of CreERT2.
Journal of Immunology 182 (9):5633-40, 2009.
10 New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by
growth factor signaling. Kentaro Suzuki, Aris Economides, Motoko Yanagita, Daniel Graf,
Gen Yamada. Curr Opin Genet Dev. 19(5):491-6, 2009.
11 Motoko Yanagita. BMP modulators regulate the function of BMP during body patterning and
disease progression. Biofactors 35(2):113-9, 2009.
12 Mari Tanaka, Shuichiro Endo, Tomohiko Okuda, Aris N. Economides, David M. Valenzuela,
Andrew J. Murphy, Elizabeth Robertson, Takeshi Sakurai, Atsushi Fukatsu, George D.
Yancopoulos, Toru Kita, Motoko Yanagita. Expression of BMP-7 and USAG-1 (a BMP
antagonist) in kidney development and injury. Kidney Int. 73(2):181-91, 2008.
13 Mima A, Ichida K, Matsubara T, Kanamori H, Inui E, Tanaka M, Manabe Y, Iehara N, Tanaka
Y, Yanagita M, Yoshioka A, Arai H, Kawamura M, Usami K, Hosoya T, Kita T, Fukatsu A.
Acute renal failure after exercise in a Japanese sumo wrestler with renal hypouricemia. Am J
Med Sci. 336(6):512-4, 2008.
14 Murashima-Suginami A, Takahashi K, Sakata T, Tsukamoto H, Sugai M, Yanagita M, Shimizu
A, Sakurai T, Slavkin HC, Bessho K. Enhanced BMP signaling results in supernumerary tooth
formation in USAG-1 deficient mouse. Biochem Biophys Res Commun. 2008 May
16;369(4):1012-6.
18) Ryosuke Takahashi
1. ○ Yamanaka, K., Chun, S.J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann,D.H.,
Takahashi, R., Misawa, H., Cleveland, D.W. (2008) Astrocytes as determinants of disease
progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11:251-253
2.
Moriwaki, Y., Kim,Y.J., Ido, Y., Misawa, H., Kawashima, K., Endo, S., Takahashi, R.(2008)
L347P PINK1 mutant that fails to bind to Hsp90/cdc37 chaperones is rapidlydegraded in a
proteasome-dependant manner. Neurosci Res 61:43-8
108
3.
Ogawa, M., Mizuguchi, K., Ishiguro, A., Koyabu, Y., Imai, Y., Takahashi, R., Mikoshina, K.
and Aruga, J.(2008) Rines/RNF180, a novel RING finger gene-encoded product, is a
membrane-bound ubiquitin ligase. Gene Cells 13: 397-409
4.
○ Imai, Y., Gehrke, S., Wang, H.Q., Takahashi, R., Hasegawa, K., Oota, E., Lu, B.
(2008)Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic
neuronsin Drosophila. EMBO J 27:, 2432-43.
5.
○ Wang, H.Q., Imai, Y., Inoue, H., Kataoka, A., Iita, S., Nukina, N. and Takahashi, R.
(2008)Pael-R transgenic mice crossed with parkin deficient mice displayed progressive
andselective catecholaminergic neuronal loss. J Neurochem 107: 171-85.
6.
Fujiwara, M., Marusawa, H., Wang, H.Q., Iwai, A., Ikeuchi, K., Imai, Y., Kataoka, A., Nukina,
N., Takahashi, R. and Chiba, T. (2008) Parkin as a tumor suppressor gene for hepatocellular
carcinoma. Oncogene 27: 6002-11.
7.
Kawamoto, Y., Kobayashi, Y., Suzuki, Y., Inoue, H., Tomimoto, H., Akiguchi, I., Budka,
H.,Martins, L.M., Downward, J. and Takahashi, R. (2008) Accumulation of HtrA2/Omi in
neuronal and glial inclusions in brains withalpha-synucleinopathies. J Neuropathol Exp
Neurol 67: 984-93.
8.
Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T (2008) Mutant SOD1 impairs
axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.
Hum Mol Genet 18: 942-55
9.
Matsumoto R, Okada T, Mikuni N, Mitsueda-Ono T, Taki J, Sawamoto N, Hanakawa T, Miki
Y, Hashimoto N, Fukuyama H, Takahashi R, Ikeda A.(2008) Hemispheric asymmetry of the
arcuate fasciculus: a preliminary diffusion tensor tractography study in patients with unilateral
language dominance defined by Wada test. J Neurol 255:1703-11.
10. Fujita Y, Lin JX, Takahashi R, Tomimoto H (2008) Cilostazol alleviates cerebral small-vessel
pathology and white-matter lesions in stroke-prone spontaneously hypertensive rats. Brain Res
1203: 170-176
11. Kawashima S, Imamura Y, Chandana EP, Noda T, Takahashi R, Adachi E, Takahashi C, Noda
M (2008) Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular
junctions. J. Neurochem 104: 376-385
12. Kinoshita M, Takahashi R, Ikeda A (2008) Application of the 2001 diagnostic scheme and the
109
2006 ILAE report of seizure and epilepsy: a feedback from the clinical practice of adult
epilepsy. Epileptic Disord 10: 206-212
13. Ogawa M, Mizugishi K, Ishiguro A, Koyabu Y, Imai Y, Takahashi R, Mikoshiba K, Aruga J
(2008) Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound
ubiquitin ligase. Genes Cells13: 397-409
14. Kinoshita M, Takahashi R, Ikeda A. (2008) Application of the 2001 diagnostic scheme and the
2006 ILAE report of seizure and epilepsy: a feedback from the clinical practice of adult
epilepsy. Epileptic Disord 10:206-12.
15. Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, Yamakawa K, Sawada H, Izumi Y,
Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashi R,
Shimohama S.(2009) Nicotinic receptor stimulation protects nigral dopaminergic neurons in
rotenone-induced Parkinson's disease models. J Neurosci Res 87:576-85.
16. ○ Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T,
Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita
A.(2009) N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J.
Neurochem 108:350-360.
17. Kondo T, Inoue H, Usui T, Mimori T, Tomimoto H, Vernino S, Takahashi R.(2009)
Autoimmune autonomic ganglionopathy with Sjögren's syndrome: significance of ganglionic
acetylcholine receptor antibody and therapeutic approach. Auton Neurosci 146:33-35.
18. Sawada H, Oeda T, Yamamoto K, Kitagawa N, Mizuta E, Hosokawa R, Ohba M, Nishio R,
Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T.(2009) Diagnostic
accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease. Eur J Neurol
16:174-182.
19. Ikeda A, Hirasawa K, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki JY, Inouch M,
Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R. Negative motor
seizure arising from the negative motor area: is it ictal apraxia? Epilepsia 50: 2072-2084.
20. Okamoto Y, Ihara M, Fujita Y, Ito H, Takahashi R, Tomimoto H.(2009) Cortical microinfarcts
in Alzheimer's disease and subcortical vascular dementia. Neuroreport 20: 990-996.
21. Ikeuchi K, Marusawa H, Fujiwara M, Matsumoto Y, Endo Y, Watanabe T, Iwai A, Sakai Y,
Takahashi R, Chiba T.(2009)Attenuation of proteolysis-mediated cyclin E regulation by
alternatively spliced Parkin in human colorectal cancers. Int J Cancer 125: 2029-35.
110
22. Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, Kihara T,
Asada-Utsugi M, Kinoshita A, Takahashi R.(2009) Chronic cerebral hypoperfusion accelerates
amyloid beta deposition in APPSwInd transgenic mice. .Brain Res 1294:202-10.
23. Kobayashi K, Okamoto Y, Inoue H, Usui T, Ihara M, Kawamata J, Miki Y, Mimori T,
Tomimoto H, Takahashi R. (2009) Leukoencephalopathy with cognitive impairment following
tocilizumab for the treatment of rheumatoid arthritis (RA).Intern Med 48: 1307-9.
24. Matsui H, Taniguchi Y, Inoue H, Uemura K, Takeda S, Takahashi R.(2009) A chemical
neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and
persistent loss of dopamine neurons in medaka fish. Neurosci Res 65: 263-71.
25. Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahashi R.(2009)Mutations in LGI1
gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: The first
report from Asian families.Epilepsia 51: 690-693
26. Usui K, Ikeda A, Nagamine T, Matsubayashi J, Matsumoto R, Hiraumi H, Kawamata J,
Matsuhashi M, Takahashi R, Fukuyama H.(2009)Abnormal auditory cortex with giant N100m
signal in patients with autosomal dominant lateral temporal lobe epilepsy. Clin Neurophysiol
120, 1923-6.
27. Uyama N, Uchihara T, Mochizuki Y, Nakamura A, Takahashi R, Mizutani T.(2009) Selective
nuclear shrinkage of oligodendrocytes lacking glial cytoplasmic inclusions in multiple system
atrophy: a 3-dimensional volumetric study. J Neuropathol Exp Neurol 68:1084-91.
28. Takahashi R. (2009) Edaravone in ALS. Exp Neurol. 217: 235-236
29. Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T. (2009) Mutant SOD1 impairs
axonal transport of choline acetyltransferase and acetylcholine release by sequestering
KAP3..Hum Mol Genet 18:942-955.
30. Yamakawa K, Izumi Y, Takeuchi H, Yamamoto N, Kume T, Akaike A, Takahashi R,
Shimohama S, Sawada H.(2010)Dopamine facilitates alpha-synuclein oligomerization in
human neuroblastoma SH-SY5Y cells. Biochem Biophys Res Commun 391:129-134.
31. Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, Kinoshita A,
Takahashi R.(2010) PI3K inhibition causes the accumulation of ubiquitinated presenilin 1
without affecting the proteasome activity. Biochem. Biophys. Res. Commun 391:1240-5.
111
32. ○ Matsui H, Taniguchi Y, Inoue H, Kobayashi Y, Sakaki Y, Toyoda A, Uemura K,
Kobayashi D, Takeda S, Takahashi R.(2010) Loss of PINK1 in medaka fish (Oryzias latipes)
causes late-onset decrease in spontaneous movement. Neurosc.i Res 66:151-61
33. Kawamoto, Y., Ito, H., Kobayashi, Y., Suzuki, Y., Ihara, M., Kawamata, J., Akiguchi, I.,
Fujimura, H., Sakoda, S., Kusaka, H., Hirano, A., Takahashi, R. (2010)
HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn from patients with
sporadic and SOD1 mutant amyotrophic lateral sclerosis. Neuropath. Appl Neurobiol
36:331-44.
34. Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T,
Ito H, Tomimoto H, Takahashi R. (2010) Nonhypotensive Dose of Telmisartan Attenuates
Cognitive Impairment Partially due to Peroxisome Proliferator-Activated Receptor-γ
Activation in Mice with Chronic Cerebral Hypoperfusion. Stroke. 41:1798-1806..
35. ○ Nishio K, Ihara M, Yamasaki N, Kalaria R N, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama
H, Miyakawa T, Takahashi R, Tomimoto H. (2010) A mouse model characterizing features of
vascular dementia with hippocampal atrophy. Stroke 41:1278-84.
36. Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K. (2010) Protein disulfide
isomerase-immunopositive inclusions in patients with Alzheimer disease. Brain Res
1349:90-96.
37. ○ Matsui H, Ito H, Inoue H, Taniguchi Y, Takeda S, Takahashi R. (2010) Proteasome
inhibition in medaka brain induces the features of Parkinson disease. J Neurochem 115:178-87.
38. Hideyama T, Yamashita T, Suzuki T, Tsuji S, Higuchi M, Seeburg P H, Takahashi R, Misawa
H, Kwak S. (2010) Induced loss of ADAR2 engenders slow death of motor neurons from Q/R
site-unedited GluR2. J Neurosci 30:11917-25.
39. ○ Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R. (2010) Ammonium chloride and
tunicamycin are novel toxins for dopaminergic neurons and induced Parkinson’s disease-like
phenotypes in medaka fish. J Neurochem 115:1150-60.
40. ○ Imai Y, Kanao T, Sawada T, Kobayashi Y, Moriwaki Y, Ishida Y, Takeda K, Ichijo H, Lu
B, Takahashi R. (2010) The loss of PGAM5 suppresses the mitochondrial degeneration caused
by inactivation of PINK1 in Drosophila. Plos Genetics 6: e1001229.
41. ○ Matsui H, Taniguchi Y, Inoue H, Kobayashi Y, Sakaki Y, Toyoda A, Uemura K,
Kobayashi D, Takeda S, Takahashi R. (2010) Loss of PINK1 in medaka fish (Oryzias latipes)
112
causes late-onset decrease in spontaneous movement. Neuroscie Res 66: 151-161
42. Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, Kinoshita A,
Takahashi R. (2010) PI3K inhibition causes the accumulation of ubiquitinated presenilin 1
without affecting the proteasome activity. Biochem Biophys Res Commun 391: 1240-1245
43. Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-Kondoh S, Hiraoka M, Ito H, Takahashi R.
(2010) Early protective effect of bone marrow mononuclear cells against ischemic white matter
damage through augmentation of cerebral blood flow. Stroke 41: 2938-2943
44. Kawamoto Y, Ito H, Kobayashi Y, Suzuki Y, Takahashi R.(2010) Localization of HtrA2/Omi
immunoreactivity in brains affected by Alzheimer's disease. Neuroreport . 21: 1121-1125
45. Koganemaru S, Mima T, Thabit MN, Ikkaku T, Shimada K, Kanematsu M, Takahashi K, Fawi
G, Takahashi R, Fukuyama H, Domen K. (2010) Recovery of upper-limb function due to
enhanced use-dependent plasticity in chronic stroke patients. Brain. 133: 3373-84.
46. ○ Takeuchi S, Fujiwara N, Ido A, Oono M, Takeuchi Y, Tateno M, Suzuki K, Takahashi R,
Tooyama I, Taniguchi N, Julien JP, Urushitani M. (2010) Induction of protective immunity by
vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice. J
Neuropathol Exp Neurol 69:1044-56.
47. Oyama G, Yoshimi K, Natori S, Chikaoka Y, Ren YR, Funayama M, Shimo Y, Takahashi R,
Nakazato T, Kitazawa S, Hattori N.(2010) Impaired in vivo dopamine release in parkin
knockout mice. Brain Res. 1352: 214-222.
48. Saiki H, Hayashi T, Takahashi R, Takahashi J. (2010) Objective and quantitative evaluation of
motor function in a monkey model of Parkinson's disease.J Neurosci Methods. 190:198-204.
49. Kinoshita M, Hitomi T, Matsuhashi M, Nakagawa T, Nagamine T, Sawada H, Saiki H,
Shibasaki H, Takahashi R, Ikeda A. (2010) How does voluntary movement stop resting tremor?
Clin Neurophysiol. 121:983-985.
50. Shiotsuki H, Yoshimi K, Shimo Y, Funayama M, Takamatsu Y, Ikeda K, Takahashi R,
Kitazawa S, Hattori N. (2010)A rotarod test for evaluation of motor skill learning.J Neurosci
Methods. 89:180-5.
51. ○ Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K, Takahashi R. (2011) The
endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced
dopaminergic neuronal death. J Biol Chem 286: 7947-57
113
52. Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka
K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A. (2010)
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper
protein: implications for neurodegeneration in Alzheimer disease. J Biol Chem 286:7619-7628.
53. ○ Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M,
Nakatsuji N, Takahashi R. (2011) Chemical library screening identifies a small molecule that
downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis. J Biomol
Screen.16: 405-414.
54. Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, Fujita K,
Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, Kaji R,
Takahashi R, Kawakami H. (2011) Clinicopathologic study on an ALS family with a
heterozygous E478G optineurin mutation. Acta Neuropathol 122: 223-229.
55. Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N,
Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. (2011) Left anterior temporal cortex actively
engages
in
speech
perception:
A
direct
cortical
stimulation
study.
Neuropsychologia.;49:1350-1354.
56. Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K,
Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R. (2011) The influence of chronic cerebral
hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice.
PLoS One 27;6:e16567.
57. Ito H, Fujita K, Nakamura M, Wate R, Kaneko S, Sasaki S, Yamane K, Suzuki N, Aoki M,
Shibata N, Togashi S, Kawata A, Mochizuki Y, Mizutani T, Maruyama H, Hirano A,
Takahashi R, Kawakami H, Kusaka H. (2011) Optineurin is co-localized with FUS in
basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease. Acta
Neuropathol 121:555-7.
58. Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N,
Mikuni N, Fukuyama H, Takahashi R. (2011) Amygdalar enlargement in patients with
temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 82:652-7.
59. Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A. Ictal
wideband ECoG: direct comparison between ictal slow shifts and high frequency oscillations.
Clin Neurophysiol. 122:1500-1504.
114
60. Kobayashi K, Matsumoto R, Kondo T, Kawamata J, Hitomi T, Inouchi M, Matsuhashi M,
Takahashi R, Ikeda A. (2011) Decreased cortical excitability in Unverricht-Lundborg disease in
the long-term follow-up: a consecutive SEP study. Clin Neurophysiol. 122:1617-1621.
61. Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H,
Harada H, Yokoi H, Arai H, Itoh H, Nakao K, Takahashi R, Tomimoto H. (2011) Angiogenic
and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic
cerebral hypoperfusion in mice. Stroke 42:1122-1128.
62. Maki T, Matsumoto R, Kohara N, Kondo T, Son I, Mezaki T, Nishino I, Ikeda A, Takahashi R.
(2011) Rippling is not always electrically silent in rippling muscle disease. Muscle Nerve
45:303.
63. Tabu H, Mima T, Aso T, Takahashi R (2011) Fukuyama H. Functional relevance of
pre-supplementary motor areas for the choice to stop during Stop signal task. Neurosci Res 70:
277-284.
64. Hitomi T, Ikeda A, Kondo T, Imamura H, Inouchi M, Matsumoto R, Terada K, Kanda M,
Matsuhashi M, Nagamine T, Shibasaki H, Takahashi R. (2011) Increased cortical
hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus
epilepsy. Mov Disord. 26:1509-1514.
65. Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R.
(2011) Angiogenic roles of adrenomedullin through vascular endothelial growth factor
induction. Neuroreport. 22:442-7.
66. Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M,
Tomimoto H. (2011) Watershed infarcts in a multiple microembolic model of monkey.
Neurosci Lett. 499:80-83.
67. Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, Fujita K,
Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, Kaji R,
Takahashi R, Kawakami H. (2011) Clinicopathologic study on an ALS family with a
heterozygous E478G optineurin mutation. Acta Neuropathol. 122:223-9.
68. Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H,
Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R. (2011) Colocalization of
14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic
lateral sclerosis cases and the animal model. PLoS One. 6:e20427.
115
69. ○ Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K. (2011) Protein disulfide isomerase
immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy. Int J
Neurosci 121:543-550.
70. ○ Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M,
Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A.
(2011) N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ
production. J Neurochem 119:354-363.
71. ○ Honjo Y, Kaneko S, Ito H, Horibe T, Nagashima M, Nakamura M, Fujita K, Takahashi R,
Kusaka H, Kawakami K. Protein disulfide isomerase-immunopositive inclusions in patients
with amyotrophic lateral sclerosis.Amyotroph Lateral Scler. 12:444-450.
72. Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata
J, Ikemoto A, Kawamoto Y, Takahashi R, Ito H. (2011) An autopsy case of SOD1-related ALS
with TDP-43 positive inclusions.Neurology. 77:1993-5.
73. Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S,
Fukuyama H, Takahashi R, Najm I, Shibasaki H, Lüders HO. (2011) Parieto-frontal network in
humans studied by cortico-cortical evoked potential.Hum Brain Mapp doi:
10.1002/hbm.21407.
74. Tanioka K, Nagao M, Yamamoto M, Matsumura Y, Tabu H, Matsushima A, Uemura K,
Matsumoto R, Ito Y, Takakura S, Takahashi R, Ichiyama S. (2012) Disseminated Nocardia
farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case
report and literature review.J Infect Chemother 18: 390-4
75. Hitomi T, Ikeda A, Inouchi M, Imamura H, Nakagawa T, Fumuro T, Matsumoto R, Takahashi
R. (2011) Transient myoclonic state with asterixis: primary motor cortex hyperexcitability is
correlated with myoclonus.Intern Med 50:2303-2309.
76. ○ Tabu H, Mima T, Aso T, Takahashi R, Fukuyama H. (2012) Common inhibitory prefrontal
activation during inhibition of hand and foot responses.Neuroimage. 59: 3373-3378.
77. ○ Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Iwamoto Y,
Miyakawa T, Suhara T, Trojanowski JQ, Lee VM, Takahashi R. P301S mutant human tau
transgenic mice manifest early symptoms of human tauopathies with dementia and altered
sensorimotor gating. PloS One 6: e21050
78. ○ Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y,
116
Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M. (2012)
Selective white matter abnormalities in a novel rat model of vascular dementia.Neurobiol
Aging 33:1012.e25-35.
79. Hitomi T, Kondo T, Kobayashi K, Matsumoto R, Takahashi R, Ikeda A. (2012) Clinical
anticipation in Japanese families of benign adult familial myoclonus epilepsy.Epilepsia.
53:e33-36.
80. Okamoto Y, Yamamoto T, Raj N Kalaria, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K,
Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M. (2012) Cerebralhypoperfusion
accelerates cerebral amyloid angiopathy and promotes corticalmicroinfarcts. Acta Neuropathol.
123:381-94.
81. Hase Y, Okamoto Y, Fujita Y, Kitamura A, Nakabayashi H, Ito H, Maki T, Washida K,
Takahashi R, Ihara M. (2012) Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and
hemorrhage in mice with focal cerebral ischemia.Exp Neurol. 233: 523-533.
82. Kawamoto Y, Ito H, Ihara M, Takahashi R. Immunohistochemical localization of X-linked
inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.Neuroreport.
23:162-167.
83. ○ Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni
N, Ishizu K, Takahashi R, Fukuyama H. (2012) Temporal Lobe Epilepsy with Amygdala
Enlargement: A Morphologic and Functional Study.J Neuroimaging. 2012 Feb 3. doi:
10.1111/j.1552-6569.2011.00694.x.
84. Ihara M, Okamoto Y, Takahashi R. Suitability of the Montreal Cognitive Assessment versus
the Mini-Mental State Examination in Detecting Vascular Cognitive Impairment.J Stroke
Cerebrovasc Dis. 2012 Feb 4.
85. ○ Kanao T, Sawada T, Davies SA, Ichinose H, Hasegawa K, Takahashi R, Hattori N, Imai Y.
(2012) The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic
Neuron Survival in Drosophila. PLoS One. 7:e30958. Epub 2012 Feb 29.
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20) Kenji Kawano
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Miura K, Kobayashi Y, Kawano K. Ocular responses to brief motion of textured backgrounds
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Li Zhihong, Ge Shunnan, Zhang Fuxing, Zhang Ting, Mizuno N, Hioki H, Kaneko T（2012）
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Tanaka T, Aoyagi T, Kaneko T（2012） Replicating receptive fields of simple and complex
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Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T,
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Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto
K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M,
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*Honda Y, Furuta T, Kaneko T, Shibata H, Sasaki H (2011) Patterns of Axonal
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Ma Y, *Hioki H, Konno M, Pan S, Nakamura H, Nakamura KC, Furuta T, Li J-L, Kaneko
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Wu S, Esumi S, Watanabe K, Chen J, Nakamura KC, Nakamura K, Kometani K, Minato N,
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and proliferation of intermediate progenitors of GABAergic neurons in the mouse
telencephalon. Development138(12):2499-509
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11. Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido
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platform using human iPS cell-derived neurons for the treatment of Alzheimer's
disease. PlosONE, vol. 6 (no. 9), article e25788
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horn. Molecular Pain, vol. 7 (no. 1), article 76
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to corticothalamic neurons in the rat barrel cortex. Journal of Neuroscience , vol. 31 (no. 50),
pp. 18223-28236
14. Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M,
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rat posterior thalamic nuclei: A single neuron tracing study with viral vectors. Cerebral
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15. Ohira K, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Tanaka Y, Funatsu N, Shimizu K,
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neurogenesis of neocortical layer 1 progenitor cells. Nature Neuroscience vol. 13 (no. 2), pp.
173-179
16. Furuta T, Urbain N, Kaneko T, *Deschênes M(2010)
Corticofugal control of
vibrissa-sensitive neurons in the interpolaris nucleus of the trigeminal complex. The Journal
of Neuroscience, vol. 30 (no. 5), pp. 1832-1838
17. Toyoda H, Saito M, Okazawa M, Hirao K, Sato H, Abe H, Takada K, Funabiki K, Takada M,
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cholinergic neurons of the basal forebrain. The Journal of Neuroscience , vol. 30 (no. 16), pp.
5677-5689
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J-L. Coexpression of VGLUT1 and VGLUT2 in trigeminothalamic projection neurons in the
principal sensory trigeminal nucleus of the rat. The Journal of Comparative Neurology , vol.
518 (no. 15), pp. 3149-3168
19. Kuramoto E, Fujiyama F, Nakamura KC, Tanaka Y, Hioki H, *Kaneko T (2010)
Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents
to the rat motor thalamic nuclei. European Journal of Neuroscience , vol. 33 (no. 1), pp.
95-109
20. Fujiyama F, Sohn J, Nakano T, Furuta T, Nakamura KC, Matsuda W, *Kaneko T (2011)
Exclusive and common targets of neostriatofugal projections of rat striosome neurons: a single
neuron-tracing study using a viral vector. European Journal of Neuroscience , vol. 33 (no. 4):
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21. *Tanaka T, Kaneko T, Aoyagi T (2009) Recurrent infomax generates cell assemblies, neuronal
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of Neuroscience, vol. 28 (no. 10): 2053-2064
23. Pang Y-W, Ge S-N, Nakamura KC, *Li J-L, Xiong K-H, Kaneko T, Mizuno N (2009) Axon
terminals expressing vesicular glutamate transporter VGLUT1 or VGLUT2 within the
trigeminal motor nucleus of the rat: origins and distribution patterns. The Journal of
Comparative Neurology, vol. 512 (no. 5): 595-612
24. Hioki H, Kuramoto E, Konno M, Kameda H, Takahashi Y, Nakano T, Nakamura KC, *Kaneko
T. (2009)
High-level transgene expression in neurons by lentivirus with Tet-Off
system. Neuroscience Research, vol. 63 (no. 2): 149-154
25. Ide Y, Fujiyama F, Okamoto-Furuta K, Tamamaki N, Kaneko T, *Hisatsune T (2008) Rapid
integration of young newborn dentate gyrus granule cells into the adult hippocampal
circuitry. European Journal of Neuroscience, vol. 28 (no. 12): 2381-2392
26. Kuramoto E, Furuta T, Nakamura KC, Unzai T, Hioki H, *Kaneko T (2009) Two types of
thalamocortical projections from the motor thalamic nuclei of the rat: A single neuron tracing
study using viral vectors. Cerebral Cortex, vol. 19 (no. 9), pp. 2065-2077
27. Matsuda W, Furuta T, Nakamura KC, Hioki H, Fujiyama F, Arai R, *Kaneko T (2009) Single
nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations
in the neostriatum. The Journal of Neuroscience, vol. 29 (no. 2): 444-453
28. Tanahira C, Higo S, Watanabe K, Tomioka R, Ebihara S, Kaneko T, *Tamamaki N (2009)
Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic
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31. Furuta T, Kaneko T, *Deschênes M(2009)Septal neurons in barrel cortex derive their receptive
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T (2009) Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons
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34. Furuta T, Timofeeva E, Nakamura Ko, Okamoto K, Kaneko T, *Deschenes M (2008)
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8), pp. 1789-1797
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78-87
36. Basu K, Gravel C, Tomioka R, Kaneko T, Tamamaki N, *Sík A. (2008) Novel strategy to
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Neuroscience Methods, vol. 170 (no. 2), pp. 212-219
37. Kameda H, Furuta T, Matsuda W, Ohira K, Nakamura Ko, Hioki H, *Kaneko T(2008)
Targeting green fluorescent protein to dendritic membrane in central neurons. Neuroscience
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38. Toyoda H, Saito M, Sato H, Dempo Y, Ohashi A, Hirai T, Maeda Y, Kaneko T, *Kang
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basal forebrain. Journal of Neurophysiology, vol. 99 (no. 5), pp. 2126-2133
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Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy
Undergoing Leptin Replacement Therapy. J Clin Endocrinol Metab
3.
Arai H, Ouchi Y, Yokode M, Ito H, Uematsu H, Eto F, Oshima S, Ota K, Saito Y, Sasaki H,
Tsubota K, Fukuyama H, Honda Y, Iguchi A, Toba K, Hosoi T, Kita T, Aging MoSf (2012)
Toward the realization of a better aged society: messages from gerontology and geriatrics.
Geriatr Gerontol Int 12: 16-22
4.
Asada T, Takaya S, Takayama Y, Yamauchi H, Hashikawa K, Fukuyama H (2010) Reversible
alcohol-related dementia: a five-year follow-up study using FDG-PET and neuropsychological
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Aso K, Hanakawa T, Aso T, Fukuyama H (2010) Cerebro-cerebellar interactions underlying
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Badry R, Mima T, Aso T, Nakatsuka M, Abe M, Fathi D, Foly N, Nagiub H, Nagamine T,
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Fathi D, Ueki Y, Mima T, Koganemaru S, Nagamine T, Tawfik A, Fukuyama H (2010) Effects
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10. Fujie S, Namiki C, Nishi H, Yamada M, Miyata J, Sakata D, Sawamoto N, Fukuyama H,
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recognition in amnestic mild cognitive impairment. Dement Geriatr Cogn Disord 26: 432-439
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activation during encoding and recognition of male and female faces. Brain Imaging Behav 4:
55-67
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autobiographical memory retrieval with special reference to default mode network. Open
Neuroimag J 5: 14-23
22. Ino T, Tokumoto K, Usami K, Kimura T, Hashimoto Y, Fukuyama H (2008) Longitudinal
fMRI study of reading in a patient with letter-by-letter reading. Cortex 44: 773-781
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Fukuyama H (2010) Gait disturbance associated with white matter changes: a gait analysis and
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34. Koganemaru S, Domen K, Fukuyama H, Mima T (2012) Negative emotion can enhance human
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35. Kohno S, Sawamoto N, Urayama S, Aso T, Aso K, Seiyama A, Fukuyama H, Le Bihan D
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36. Kubota M, Miyata J, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A,
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38. Maezawa H, Yoshida K, Matsuhashi M, Yokoyama Y, Mima T, Bessho K, Fujita S, Nagamine
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39. Maezawa H, Yoshida K, Nagamine T, Matsubayashi J, Enatsu R, Bessho K, Fukuyama H
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41. Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S,
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43. Matsuyoshi D, Ikeda T, Sawamoto N, Kakigi R, Fukuyama H, Osaka N (2010) Task-irrelevant
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53. Nakamura K, Oga T, Fukuyama H (2012) Task-sensitivity of unconscious word processing in
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27) Yasuhiko Tabata
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945-952
30. ○ Sasaki K, Kuroda R, Ishida K, Kubo S, Matsumoto T, Mifune Y, Kinoshita K, Tei K,
Akisue T, Tabata Y, Kurosaka M (2008) Enhancement of tendon-bone osteointegration of
anterior cruciate ligament graft using granulocyte colony-stimulating factor. The American
journal of sports medicine 36: 1519-1527
31. ○ Sasaki N, Minami T, Yamada K, Yamada H, Inoue Y, Kobayashi M, Tabata Y (2008) In
vivo effects of intra-articular injection of gelatin hydrogen microspheres containing basic
fibroblast growth factor on experimentally induced defects in third metacarpal bones of horses.
American journal of veterinary research 69: 1555-1559
32. ○ Sato S, Nitta Y, Saiki Y, Kawamoto S, Iguchi A, Kaku M, Tabata Y, Tabayashi K (2008)
Enhanced perigraft angiogenesis prevents prosthetic graft infection. Annals of thoracic surgery
33. ○ Shibusawa Y, Negishi I, Tabata Y, Ishikawa O (2008) Mouse model of dermal fibrosis
induced by one-time injection of bleomycin-poly(L-lactic acid) microspheres. Rheumatology
47: 454-457
34. ○ Sonoda A, Nitta N, Ohta S, Seko A, Jo JI, Morikawa S, Tabata Y, Takahashi M, Murata K
(2008) Development of a conjugated gadolinium and cisplatin-gelatin possessing properties as
an intravascular contrast agent for MR imaging. European journal of radiology 71: 570-575
35. Tabata Y (2008) Current status of regenerative medical therapy based on drug delivery
technology. Reproductive BioMedicine Online 16: 70-80
36. Tabata Y (2008) Regenerative medical therapy from the viewpoint of biomaterials.
Inflammation and regeneration 28: 86-95
37. ○ Takehara N, Tsutsumi Y, Tateishi K, Ogata T, Tanaka H, Ueyama T, Takahashi T,
148
Takamatsu T, Fukushima M, Komeda M, Yamagishi M, Yaku H, Tabata Y, Matsubara H, Oh
H (2008) Controlled delivery of basic fibroblast growth factor promotes human
cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial
infarction. J Am Coll Cardiol 52: 1858-1865
38. ○ Takemoto S, Morimoto N, Kimura Y, Taira T, Kitagawa T, Tomihata K, Tabata Y, Suzuki
S (2008) Preparation of Collagen/Gelatin Sponge Scaffold for Sustained Release of bFGF.
Tissue Eng Part A 14: 1629-1638
39. ○ Takigawa M, Kikuchi T, Kubota S, Asaumi K, Kawaki H, Nishida T, Kawata K, Mitani S,
Tabata Y, Ozaki T (2008) Promotion of Bone Regeneration by CCN2 Incorporated into Gelatin
Hydrogel. Tissue Engineering Part A 14: 1089-1098
40. ○ Tamura E, Fukuda H, Tabata Y, Nishimura M (2008a) Use of the buccal fad pad for vocal
cord augmentation. Acta Oto-Laryngologica 128: 219-224
41. ○ Tazaki J, Akazawa T, Murata M, Yamamoto M, Tabata Y, Hino J, Arisue M, Shibata T
(2008) Comparison of HAp and β-TCP in BMP-2 Dose-response and Release Study. Key
Engineering Materials 361-363: 1033-1036
42. ○ Tomioka A, Tanaka M, De Velasco MA, Anai S, Takada S, Kushibiki T, Tabata Y, Rosser
CJ, Uemura H, Hirao Y (2008) Delivery of PTEN via a novel gene microcapsule sensitizes
prostate cancer cells to irradiation. Mol Cancer Ther 7: 1864-1870
43. ○ Tsubouchi M, Morishita R, Tabata Y, Matsui S, Kawakami K (2008) Critical issues for
effective collaboration between academia and industry in the field of regenerative medicine in
Japan. Regenerative medicine 3: 497-504
44. ○ Xia Z, Abe K, Furusu A, Miyazaki M, Obata Y, Tabata Y, Koji T, Kohno S (2008)
Suppression of renal tubulointerstitial fibrosis by small interfering RNA targeting heat shock
protein 47. Am J Nephrol 28: 34-46
45. Zhao Q-Q, Chen J-L, Han M, Liang W-Q, Tabata Y, Gao J-Q (2008) Combination of
Poly(ethylenimine) and Chitosan Induces High Gene Transfection Efficiency and Low
Cytotoxicity. Journal of Bioscience and Bioengineering 105: 65-68
46. ○ Akagawa Y, Kubo T, Katsunori K, Hayashi K, Doi K, Matsuura A, Morita K, Takeshita R,
Yuan Q, Tabata Y (2009) Initial bone regeneration around fenestrated implants in Beagle dogs
using basic fibroblast growth factor-gelatin hydrogel complex with varying biodegradation
rates. Journal of Prosthodontic Research 53: 41-47
149
47. Guo X, Park H, Liu G, Liu W, Cao Y, Tabata Y, Kasper FK, Mikos AG (2009) In vitro
generation of an osteochondral construct using injectable hydrogel composites encapsulating
rabbit marrow mesenchymal stem cells. Biomaterials 30: 2741-2752
48. ○ Hashimoto T, Koyama H, Miyata T, Hosaka A, Tabata Y, Takato T, Nagawa H (2009)
Selective and Sustained Delivery of Basic Fibroblast Growth Factor (bFGF) for Treatment of
Peripheral Arterial Disease: Results of a Phase I Trial. Eur J Vasc Endovasc Surg 38: 71-75
49. He CX, Tabata Y, Gao JQ (2009) Non-viral gene delivery carrier and its three dimensional
transfection system. Int J Pharm 386: 232-242
50. Hyoudou K, Nishikawa M, Ikemura M, Kobayashi Y, Mendelsohn A, Miyazaki N, Tabata Y,
Yamashita F, Hashida M (2009) Prevention of pulmonary metastasis from subcutaneous
tumors by binary system-based sustained delivery of catalase. Journal of controlled release
137: 110-115
51. ○ Imamura M, Negoro H, Kanematsu A, Yamamoto S, Kimura Y, Nagane K, Yamasaki T,
Kanatani I, Ito N, Tabata Y, Ogawa O (2009) Basic fibroblast growth factor causes urinary
bladder overactivity through gap junction generation in the smooth muscle. Am J Physiol Renal
Physiol 297: F46-54
52. ○ Inoue K, Aoi N, Yamauchi Y, Sato T, Suga H, Eto H, Kato H, Tabata Y, Yoshimura K
(2009) TGF-β2 is specifically expressed in human dermal papilla cells and modulates hair
folliculogenes. J Cell Mol Med 13: 4643-4656
53. Inoue S, Iida Y, Otani Y, Hirano Y, Tabata Y (2009) Adhesion behavior of human
adipo-stromal cells on self-assembled monolayers with different surface densities or gradients
RGD peptide. J Biomater Sciences Polym Eds 20: 495-510
54. Inoue S, Imamura M, Hirano Y, Tabata Y (2009) Adhesion and proliferation of human
adipo-stromal cells for two- or three dimensional poly(ethylene terephthalate) substrates with
or without RGD immobilization. J Biomater Sciences Polym Eds, 20: 721-736
55. Inoue S, Imamura M, Tabata Y (2009) Adipogenic differentiation of adipo-stromal cells
incubated with basic fibroblast growth factor in the solution and coated form. J Biomater
Sciences Polym Eds 20: 483-494
56. ○ Ishimatsu H, Kitamura C, Morotomi T, Tabata Y, Nishibara T, Chen K, Terashita M (2009)
Formation of Dentinal Bridge on Surface of Regenerated Dental Pulp in Dentin Defects by
150
Controlled Release of Fibroblast Growth Factor-2 From Gelatin Hydrogels. Journal of
endodontics 35: 858-865
57. Jo J, Tabata Y (2009) Gene delivery system based on cationized polysaccharide carriers. , Vol.
2, California: American Scientific Publishers.
58. ○ Katsuno A, Aimoto T, Uchida E, Tabata Y, Miyamoto M, Tajiri T (2009) The controlled
release of basic fibroblast growth factor promotes a rapid healing of pancreaticojejunal
anastomosis with potent angiogenesis and accelerates apoptosis in granulation tissue.
59. ○ Kawanaka H, Takagi G, Miyamoto M, Tara S, Takagi I, Takano H, Yasutake M, Tabata Y,
Mizuno K (2009) Therapeutic angiogenesis by controlld-release fibroblast growth factor in a
patient with Churg-Strauss syndrome complicated by an intractable ischemic leg ulcer. Am J
Med Sci 338: 341-342
60. Kimura Y, Tabata Y (2009) Controlled Release of Stromal Cell-Derived Factor-1 From Gelatin
Hydrogels Enhances Angiogenesis. J Biomater Sciences Polym Eds 21: 37-51
61. ○ Kishimoto Y, Hirano S, Kitani Y, Suehiro A, Umeda H, Tateya I, Kanemaru S, Tabata Y,
Ito J (2009) Chronic vocal fold scar restoration with hepatocyte growth factor hydrogel.
Laryngoscope 120: 108-113
62. ○ Kodama N, Nagata M, Tabata Y, Ozeki M, Ninomiya T, Takagi R (2009) A local bone
anabolic effect of rhFGF2-impregnated gelatin hydrogel by promoting cell proliferation and
coordinating osteoblastic differentiation. Bone 44: 699-707
63. ○ Komeda M, Marui A, Tambara K, Yamamoto M, Saji Y, Nishina T, Tabata Y (2009)
Biologic anastomosis: The first case of biologic coronary bypass surgey. The Journal of
Thoracic and Cardiovascular Surgery 138: 775-777
64. Li L, Okada H, Takemura G, Esaki M, Kobayashi H, Kanamori H, Kawamura I, Maruyama R,
Fujiwara T, Fujiwara H, Tabata Y, Minatoguchi S (2009) Sustained release of erythropoietin
using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia.
Journal of the American College of Cardiology 53: 2378-2388
65. ○ Lin X, Jo H, Ishii T, Fujita M, Fu M, Tambara K, Yamamoto M, Tabata Y, Komeda M,
Matsuoka S (2009) Controlled release of matrix metalloproteinase-1 plasmid DNA prevents
left ventricular remodeling in chronic myocardial infarction of rats. Circ J 73: 2315-2321
66. ○ Lin X, Tammbara K, Fu M, Yamamoto M, Premaratne G, Sakakibara Y, Marui A, Ikeda T,
151
Komeda M, Tabata Y (2009) Controlled release of matrix metalloproteinase 1 with or without
skeletal myoblasts transplantion improves cardiac function of rat hearts with chronic
myocardial infarction. Tissu Engineering Part A 15: 2699-2706
67. ○ Matsumoto G, Omi Y, Kubota E, Ozono S, Tsuzuki H, Kinoshita Y, Yamamoto M, Tabata
Y (2009) Enhanced Regeneration of Critical Bone Defects Using a Biodegradable Gelatin
Sponge and β-Tricalcium Phosphate with Bone Morphogenetic Protein-2. Journal of
Biomaterials Applications 24: 327-342
68. Nagane K, Kitada M, Wakao S, Dezawa M, Tabata Y (2009) Practical induction system for
dopamine-producing cells from bone marrow stromal cells by spermine-pullulan-mediated
reverse transfection method. Tissue Engineering Part A 15: 1655-1665
69. ○ Narita A, Takahara M, Ogino T, Fukushima S, Kimura Y, Tabata Y (2009) Effect of gelatin
hydrogel incorporating fibroblast growth factor 2 on human meniscal cells in an organ culture
model. Knee 16: 285-289
70. Neethu Mohan, Prabha D. Nair, Tabata Y (2009) A 3D biodegradable protein based matrix for
cartilage tissue engineering and stem cell differentiation to cartilage. J Mater Sc i: Mater M ed
20: 49-60
71. ○ Nitta N, Ohta S, Tanaka T, Takazakura R, Toyama T, Sonoda A, Seko A, Furukawa A,
Takahashi M, Murata K, Kurumi Y, Tani T, Sakamoto T, Tabata Y (2009) An initial clinical
study on the efficacy of cisplatin-releasing gelatin microspheres for metastatic liver tumors.
European journal of radiology 71: 519-526
72. Ogawa T, Akazawa T, Tabata Y (2009) In vitro proliferation and chondrogenic differentiation
of rat bone marrow stem cells cultured with gelatin hydrogel microspheres for TGF-β1. J
Biomater Sciences Polym Eds 21: 609-621
73. ○ Ohta S, Nitta N, Sonoda A, Seko A, Tanaka T, Takahashi M, Kimura Y, Tabata Y, Murata
K (2009) Cisplatin-conjugated degradable gelatin microspheres: fundamental study in vitro. Br
J Radiol 82: 380-385
74. ○ Ohta S, Nitta N, Sonoda A, Seko A, Tanaka T, Takahashi M, Takemura S, Tabata Y,
Murata K (2009) Prolonged local persistence of cisplatin-loaded gelatin microspheres and their
chemoembolic anti-cancer effect in rabbits. European journal of radiology
75. Park H, Guo X, Temenoff JS, Tabata Y, Caplan AI, Kasper FK, Mikos AG (2009) Effect of
Swelling Ratio of Injectable Hydrogel Composites on Chondrogenic Differentiation of
152
Encapsulated Rabbit Marrow Mesenchymal Stem Cells In Vitro. Biomacromolecules 10:
541-546
76. Park H, Temenoff JS, Tabata Y, Caplan AI, Raphael RM, Jansen JA, Mikos AG (2009) Effect
of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal
stem cells encapsulated in injectable hydrogel composites. J Biomed Mater Res A 88: 889-897
77. Zhao QQ, Chen JL, Lv TF, He CX, Tang GP, Liang WQ, Tabata Y, Gao JQ (2009) N/P ratio
significantly influences the transfection efficiency and cytotoxicity of a
polyethylenimine/chitosan/DNA complex. Biol Pharm Bull 32: 706-710
78. ○ Sawamura K, Ikeda T, Nagae M, Okamoto S, Mikami Y, Hase H, Ikoma K, Yamada T,
Sakamoto H, Matsuda K, Tabata Y, Kawata M, Kubo T (2009) Characterization of in vivo
effects of platelet-rich plasma and biodegradable gelatin hydrogel microspheres on degenerated
intervertebral discs. Tissue Eng Part A 15: 3719-3727
79. ○ Seko A, Nitta N, Sonoda A, Ohta S, Takahashi M, Murata K, Tabata Y (2009) Vascular
regeneration by repeated infusions of basic fibroblast growth factor in a rabbit model of hind
limb ischemia. American Journal of Roentgenology 192: 306-310
80. ○ Sonoda A, Nitta N, Ohta S, Nitta-Seko A, Murata S, Jo J, Tabata Y, Takahashi M, Tani T,
Murata K (2009) Investigation using an HER-2/neu transgenic mouse model of a newly
developed MR contrast agent with the effect of an antitumor drug. J Magn Reson Im aging 30:
907-910
81. Tabata Y (2009) Biomaterial technology for tissue engineering applications. JRSocInterface 6:
311-324
82. ○ Takaoka M, Nagata D, Kihara S, Shimomura I, Kimura Y, Tabata Y, Saito Y, Nagai R,
Sata M (2009) Periadventitial adipose tissue plays a critical role in vascular remodeling. Circ
Res 105: 906-911
83. Takaoka R, Hikasa Y, Tabata Y (2009) Vascularization Around Poly(tetrafluoroethylene)
Mesh with Coating of Gelatin Hydrogel Incorporating Basic Fibroblast Growth Factor. Journal
of Biomaterials Science 20: 1483-1494
84. ○ Takemoto Y, Kawata H, Soeda T, Imagawa K, Somekawa S, Takeda Y, Uemura S,
Matsumoto M, Fujimura Y, Jo J, Kimura Y, Tabata Y, Saito Y (2009) Human placental
ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents
prevents in-stent thrombosis. Artherioscler Thromb Vasc Biol 29: 857-862
153
85. Thakor DK, Teng YD, Tabata Y (2009) Neuronal gene delivery by negatively charged
pullulan-spermine/DNA anioplexes. Biomaterials 30: 1815-1826
86. ○ Tsuji W, Inamoto T, Yamashiro H, Ueno T, Kato H, Kimura Y, Tabata Y, Toi M (2009)
Adipogenesis Induced by Human Adipose Tissue-Derived Stem Cells. Tissue Engineering Part
A 15: 83-93
87. Young S, Patel ZS, Kretlow JD, Murphy MB, Mountziaris PM, Baggett LS, Ueda H, Tabata Y,
Jansen JA, Wong M, Mikos AG (2009) Dose effect of dual delivery of vascular endothelial
growth factor and bone morphogenetic protein-2 on bone regeneration in a rat critical-size
defect model. Tissue Engineering: Part A 15: 2347-2362
88. ○ Zhong H, Matsui O, Xu K, Ogi T, Sanada J, Okamoto Y, Tabata Y, Takuwa Y (2009) Gene
transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated polyester
stent-graft. Journal of Vascular Surgery 50: 1433-1443
89. ○ Asamura S, Mochizuki Y, Yamamoto M, Tabata Y, Isogai N (2010) Bone regeneration
using a BMP-2-saturated slow-release gelatin hydrogel sheet: evaluation in a canine orbital
floor fracture model. Ann Plast Surg 64: 496-502
90. Chandana EPS, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J,
Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y,
Matsuzaki T, Noda M (2010) Involvement of the Reck tumor suppressor protein in maternal
and embryonic vascular remodeling in mice. BMC Der Biol 10: 84
91. Chen W, Tabata Y, Tong YW (2010) Fabricating tissue engineering scaffolds for simultaneous
cell growth and drug delivery. Curr Pharm Des 16: 2388-2394
92. Chen YZ, Yao XL, Nakagawa S, Tabata Y, Gao J.Q (2010) Gene carriers and transfection
systems used in the recombination of dendritic cells for effective cancer immuno therapy. Clin
Dev Immunol 2010: 565643
93. ○ Fujiwara H, Saiki Y, Sato M, Sakamoto N, Ohashi T, Sato M, Tabata Y, Tabayashi K
(2010) Modification of the descending thoracic aortic anastomotic site using biodegradable felt:
Study in a canine model with or without basic fibroblast growth factor. J Vasc Surg 51:
194-292
94. Gao JQ, Zhao QQ, Lv TF, Shuai WP, Zhou J, Tang GP, Liang WQ, Tabata Y, Hu YL (2010)
Gene-carried chitosan-linked-PEI induced high gene transfection efficiency with low toxicity
154
and significant tumor-suppressive activity. Int J Pharm 387: 286-294
95. ○ Gunji S, Obama K, Tabata Y, Sakai Y, Hirai K, Sakai Y (2010) Controlled release of
cisplatin from biodegradable gelatin microspheres and the anti-tumor effect on mouse colon
tumor peritoneal dissemination. British Journal of Surgery 97: S6-S6
96. Guo X, Liao J, Park H, Saraf A, Raphael RM, Tabata Y, Kasper FK, Mikos AG (2010) Effects
of TGF-β3 and preculture period of osteogenic cells on the chondrogenic differentiation of
rabbit marrow mesenchymal stem cells encapsulated in a bilayered hydrogel composite. Acta
Biomater 6: 2920-2931
97. ○ Horie RT, Sakamoto T, Nakagawa T, Tabata Y, Okamura N, Tomiyama N, Tachibana M,
Ito J (2010) Sustained delivery of lidocaine into the cochlea using poly lactic/glycolic acid
microparticles. Laryngoscope 120: 377-383
98. Hu Y, Fu Y, Tabata Y, Gao J (2010) Mesenchymal stem cells: A promising targeted-delivery
vehicle in cancer gene therapy. J Control Release 147
99. ○ Ichinohe N, Nakano T, Mitaka T, Umakoshi Y, Tabata Y (2010) Proliferation and
osteogenic differentiation of rat bone marrow stromal cells on bioapatite with different
crystalline facets. J Biomed Mater Res A 93: 646-655
100.○ Inuyama Y, Kitamura C, Nishihara T, Morotomi T, Nagayoshi M, Tabata Y, Matsuo K,
Chen KK, Terashita M (2010) Effects of hyaluronic acid sponge as a scaffold on odontoblastic
cell line and amputated dental pulp. J Biomed Mater Res B Appl Biomater 92: 120-128
101.○ Ishida K, Matsumoto T, Sasaki K, Mifune Y, Tei K, Kubo S, Matsushita TT, K, Akisue T,
Tabata Y, Kurosaka M, Kuroda R (2010) Bone regeneration properties of granulocyte
colony-stimulating factor via neovascularization and osteogenesis. Tissue Eng Part A 16:
3271-3284
102.Jo J, Aoki I, Tabata Y (2010) Design of iron oxide nanoparticles with different sizes and
surface charges for simple and efficient labeling of mesenchymal stem cells. J Control Release
142: 465-473
103.Jo J, Nagane K, Yamamoto M, Tabata Y (2010) Effect of amine type on the expression of
plasmid DNA by cationized dextran. J Biomater Sciences Polym Eds 21: 225-236
104.Jo J, Okazaki A, Nagane K, Yamamoto M, Tabata Y (2010) Preparation of cationized
polysaccharides as gene transfection carrier for bone marrow-derived mesenchymal stem cells.
155
J Biomater Sciences Polym Eds 21: 185-204
105.Kabashima K, Sakabe J, Yoshiki R, Tabata Y, Kohno K, Tokura Y (2010) Involvement of Wnt
signaling in dermal fibroblasts. Am J Pathol 176: 721-732
106.○ Kato H, Suga H, Eto H, Araki J, Aoi N, Doi K, Iida T, Tabata Y, Yoshimura K (2010)
Reversible adipose tissue enlargement induced by external tissue suspension: possible
contribution of basic fibroblast growth factor in the preservation of enlarged tissue. Tissue Eng
Part A 16: 2029-2040
107.○ Kimura Y, Inamoto T, Tabata Y (2010) Adipose Tissue Formation in Collagen Scaffolds
with Different Biodegradabilities. J Biomater Sciences Polym Eds 21: 463-476
108.○ Kimura Y, Miyazaki N, Hayashi N, Otsuru S, Tamai K, Kaneda Y, Tabata Y (2010)
Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic
progenitor cells for de novo generation of bone tissue. Tissue Eng Part A 16: 1263-1270
109.○ Kimura Y, Tsuji W, Yamashiro H, Toi M, Inamoto T, Tabata Y (2010) In situ adipogenesis
in fat tissue augmented by collagen scaffold with gelatin microspheres containing basic
fibroblast growth factor. J Tissue Eng Regen Med 4: 55-61
110.Kohara H, Tabata Y (2010) Review: Tissue engineering technology to enhance cells
recruitment for regeneration therapy. J Med Biol Eng 30: 267-276
111.Kohara H, Tabata Y (2010) Tissue engineering technology to enhance cell recruitment for
regeneration therapy. Journal of Medical and Biological Engineering 30: 267-276
112.Kohara H, Tajima S, Yamamoto M, Tabata Y (2010) Angiogenesis induced by controlled
release of neuropeptide substance P. Biomaterials 31: 8617-8625
113.○ Komobuchi H, Hato N, Teraoka M, Wakisaka H, Takahashi H, Gyo K, Tabata Y,
Yamamoto M (2010) Basic fibroblast growth factor combined with biodegradable hydrogel
promotes. Acta Otolaryngol 130: 173-178
114.○ Kubo H, Tabata Y, Yamamoto M (2010) The effects of fibroblast growth factor with
sustained release method on wound healing in intestinal anastomoses. British Journal of
Surgery 97: S28-S29
115.○ Kuroda Y, Akiyama H, Kawanabe K, Tabata Y, Nakamura T (2010) Treatment of
experimental osteonecrosis of the hip in adult rabbits with a single local injection of
156
recombinant human FGF-2 microspheres. J Bone Miner Metab 28: 608-616
116.Leeuwenburgh SC, Jo J, Wang H, Yamamoto M, Jansen JA, Tabata Y (2010) Mineralization,
biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone
regeneration. Biomacromolecules 11: 2653-2659
117.Liu J, Tabata Y (2010) Photodynamic antitumor activity of fullerene modified with
poly(ethylene glycol) with different molecular weights and terminal structures. J Biomater
Sciences Polym Eds 22: 297-312
118.Liu J, Tabata Y (2010) Photodynamic therapy of fullerene modified with pullulan on hepatoma
cells. J Drug Target 18: 602-610
119.○ Mcmillan JR, Kempf M, Miyamura Y, Liu P-YA, Chen AC-H, Shimizu H, Tabata Y,
Kimble RM (2010) Animal model assessmet in vitro derived of novel denatured collagen
electrospun scaffoled for skin tissue engineering. Experimental Dermatology 19: 1032-1033
120.Mizusawa K, Igarashi R, Uehira K, Takafuji Y, Tabata Y, Tochio H, Shirakawa M, Sando S,
Aoyama Y (2010) Turn-on detection of targeted biochemical reactions by triple resonance
NMR analysis using isotope-labeled probe. Chem Lett 39: 926-928
121.Mohan N, Nair PD, Tabata Y (2010) Growth factor-mediated effects on chondrogenic
differentiation
of
mesenchymal
stem
cells
in
3D
semi-IPN
poly(vinyl
alcohol)-poly(caprolactone) scaffolds. J Biomed Mater Res A, 94A: 146-159
122.Nagane K, Jo J, Tabata Y (2010) Promoted adipogenesis of rat mesenchymal stem cells by
transfection of small interfering RNA complexed with a cationized dextran. Tissue Engineering
16: 21-31
123.○ Nakagawa T, Sakamoto T, Hiraumi H, Kikkawa YS, Yamamoto N, Hamaguchi K, Ono K,
Yamamoto M, Tabata Y, Teramukai S, Tanaka S, Tada H, Onodera R, Yonezawa A, Inui K,
Ito J (2010) Topical insulin-like growth factor 1 treatment using gelatin hydrogels for
glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC
Med 8: 76
124.Nakamura K, Tabata Y (2010) A new fluorescent imaging of renal inflammation with RCP. J
Control Release 148: 351-358
125.Ogawa T, Akazawa T, Tabata Y (2010) In Vitro proliferation and chondrogenic differentiation
of rat bone marrow stem cells cultured with gelatin hydrogel microspheres for TGF-β1 release.
157
J Biomater Sciences Polym Eds 21: 609-621
126.○ Ohta S, Nitta N, Sonoda A, Seko A, Tanaka T, Takazakura R, Furukawa A, Takahashi M,
Sakamoto T, Tabata Y, Murata K (2010) Embolization materials made of gelatin: comparison
between Gelpart and gelatin microspheres. Cardiovasc Intervent Radiol 33: 120-126
127.Pimpha N, Sunintaboon P, Inphonlek S, Tabata Y (2010) Gene delivery efficacy of
polyethyleneimine-introduced chitosan shell/poly(methyl methacrylate) core nanoparticles for
rat mesenchymal stem cells. J Biomater Sciences Polym Eds 21: 205-223
128.Ratanavaraporn J, Kanokpanont S, Tabata Y, Damrongsakkul S (2010) Modulation of in vitro
attachment, proliferation and osteogenic differentiation of rat bone-marrow-derived stem cells
using different molecular mass chitosans and their blends with gelatin. J Biomater Sciences
Polym Eds 21: 979-996
129.○ Sonoda A, Nitta N, Nitta-Seko A, Ohta S, Takamatsu S, Ikehata Y, Nagano I, Jo J, Tabata
Y, Takahashi M, Matsui O, Murata K (2010) Complex comprised of dextran magnetite and
conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential. Int J
Nanomedicine 5: 499-504
130.○ Sonoda A, Nitta N, Ohta S, Nitta-Seko A, Morikawa S, Tabata Y, Takahashi M, Murata K
(2010) Controlled release and antitumor effect of pluronic F127 mixed with cisplatin in a rabbit
model. Cardiovasc Intervent Radiol 33: 135-142
131.○ Takahashi R, Sonoda H, Tabata Y, Hisada A (2010) Formation of hepatocyte spheroids
with structural polarity and functional bile canaliculi using nanopillar sheets. Tissue Eng Part A
16: 1983-1995
132.Tanigo T, Takaoka R, Tabata Y (2010) Sustained release of water-insoluble simvastatin from
biodegradable hydrogel augments bone regeneration. J Control Release 143: 201-206
133.○ Tobe M, Obata H, Suto T, Yokoo H, Nakazato Y, Tabata Y, Saito S (2010) Long-term
effect of sciatic nerve block with slow-release lidocaine in a rat model of postoperative pain.
Anesthesiology 112: 1473-1481
134.○ Uesugi Y, Kawata H, Jo J, Saito Y, Tabata Y (2010) An ultrasound-responsive nano
delivery system of tissue-type plasminogen activator for thrombolytic therapy. J Control
Release 147: 269-277
135.○ Wakao S, Hayashi T, Kitada M, Kohama M, Matsuse D, Teramoto N, Ose T, Itokazu Y,
158
Koshino K, Watabe H, Iida H, Takamoto T, Tabata Y, Dezawa M (2010) Long-term
observation of auto-cell transplantation in non-human primate reveals safety and efficiency of
bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration Experimental
Neurology 223: 537-547
136.○ Watanabe M, Jo J, Radu A, Kaneko M, Tabata Y, Flake AW (2010) A tissue engineering
approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic
fibroblast growth factor. Tissue Eng Part A, 16
137.Wongpanit P, Ueda H, Tabata Y, Rujiravanit R (2010) In vitro and in vio release of basic
fibroblast growth factor using a silk fibroin scaffold as delivery carrier. J Biomater Sciences
Polym Eds 21: 1403-1419
138.Yamamoto M, Yanase K, Tabata Y (2010) Generation of type Ⅰ collagen gradient in
polyacrylamide hydrogels by a simple diffusion-controlled hydrolysis of amide groups.
Materials 3: 2393-2404
139.Yoshida M, Jo J, Tabata Y (2010) Augmented anti-tumor effect of dendritic cells genetically
engineered by interleukin-12 plasmid DNA. J Biomater Sciences Polym Eds 21: 659-675
140.Yoshida M, Tabata Y (2010) Tumor targeting of protein through poly (ethyleneglycol)
conjugation with metal coordination. J Nanosci Nanotechnol 10: 877-885
141.Chew SA, Kretlow JD, Spicer PP, Edwards AW, Baggett LS, Tabata Y, Kasper FK, Mikos AG
(2011) Delivery of plasmid DNA encoding bone morphogenetic protein-2 with a biodegradable
branched polycationic polymer in a critical-size rat cranial defect model. Tissue Eng Part A 17:
751-763
142.Doi N, Jo J, Tabata Y (2011) Preparation of biodegradable gelatin nanospheres with a narrow
size distribution for carrier of cellular internalization of plasmid DNA. J Biomater Sciences
Polym Eds
143.○ Fujii H, Matsuyama A, Komoda H, Sasai M, Suzuki M, Asano T, Doki Y, Kirihata M, Ono
K, Tabata Y, Kaneda Y, Sawa Y, Lee CM (2011) Cationized gelatin-HVJ envelope with
sodium borocaptate improved the BNCT efficacy for liver tumors in vivo. Radiat Oncol 6: 8
144.○ Fujita N MT, Ishida K, Sasaki K, Kubo S, Matsumoto T, Kurosaka M, Tabata Y, Kuroda R
(2011) An analysis of bone regeneration at a segmental bone defect by controlled release of
bone morphogenetic protein 2 from a biodegradable sponge composed of gelatin and β
tricalcium phosphate. J Tissue Eng Regen Med 6: 291-298
159
145.○ Fukata N, Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukui T, Matsushita M, Nishio A,
Tabata Y, Okazaki K (2011) The effective therapy of cyclosporine A with drug delivery system
in experimental colitis. J Drug Target 19: 458-467
146.Hayashi K, Tabata Y (2011) Preparation of stem cell aggregates with gelatin microspheres to
enhance biological functions. Acta Biomater 7: 2797-2803
147.He CX, Li N, Hu YL, Zhu XM, Li HJ, Han M, Miao PH, Hu ZJ, Wang G, Liang WQ, Tabata
Y, Gao JQ (2011) Effective gene delivery to mesenchymal stem cells based on the reverse
transfection and three-dimensional cell culture system. Pharm Res 28: 1577-1590
148.Higashiyama R, Nakao S, Shibusawa Y, Ishikawa O, Moro T, Mikami K, Fukumitsu H, Ueda
Y, Minakawa K, Tabata Y, Bou-Gharios G, Inagaki Y (2011) Differential contribution of
dermal resident and bone marrow-derived cells to collagen production during wound healing
and fibrogenesis in mice. J invest Dermatol 131: 529-536
149.Ishikawa H, Jo J, Tabata Y (2011) Liver anti-fibrosis therapy with mesenchymal stem cells
secreting hepatocyte growth factor. J Biomater Sciences Polym Eds in press
150.Ishimoto T, Nakano T, Yamamoto M, Tabata Y (2011) Biomechanical evaluation of
regenerating long bone by nanoindentation. J Mater Sci Mater Med 22: 969-976
151.○ Kawabata S, Asano K, Tabata Y (2011) Electrodeposition of pronectin for titanium to
augment the gingival epithelium adhesion. J Tissue Eng Regen Med: 1-5
152.○ Kawamura I, Takemura G, Tsujimoto A, Watanabe T, Kanamori H, Esaki M, Kobayashi H,
Takeyama T, Kawaguchi T, Goto K, Maruyama R, Fujiwara T, Fujiwara H, Tabata Y,
Minatoguchi S (2011) Treatment of leg ischemia with biodegradable gelatin hydrogel
microspheres incorporating granulocyte colony-stimulating factor. J Cardiovasc P harmacol
57: 416-423
153.○ Kempf M, Miyamura Y, Liu PY, Chen ACH, Nakamura H, Shimizu H, Tabata Y, Kimble
RM, McMillan JR (2011) A denatured collagen microfiber scaffold seeded with human
fibroblasts and keratinocytes for skin grafting. Biomaterials 32: 4782-4792
154.Kido Y, Jo J, Tabata Y (2011) A gene transfection for rat mesenchymal stromal cells in
biodegradable gelatin scaffolds containing cationized polysaccharides. Biomaterials 32:
919-925
160
155.○ Kitamura C, Nishihara T, Terashita M, Tabata Y, Jimi E, Washio A, Hirata S (2011)
Regeneration approaches for dental pulp and periapical tissues with growth factors,
biomaterials, and laser irradiation. Polymers 3: 1776-1793
156.Kohara H, Tabata Y (2011) Enhancement of ectopic osteoid formation following the dual
release of bone morphogenetic protein 2 and Wnt1 inducible signaling pathway protein 1 from
gelatin sponges. Biomaterials 32: 5726-5732
157.○ Kojima S, Sugiyama T, Takai S, Jin D, Shibata M, Oku H, Tabata Y, Ikeda T (2011)
Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration
surgery model. Invest Ophthalmol Vis Sci 52: 7672-7680
158.○ Kurita J, Miyamoto M, Ishii Y, Aoyama J, Takagi G, Naito Z, Tabata Y, Ochi M, Shimizu
K (2011) Enhanced vascularization by controlled release of platelet-rich plasma impregnated in
biodegradable gelatin hydrogel. Ann Thorac Surg 92: 837-844
159.○ Kusuhara H, Itani Y, Isogai N, Tabata Y (2011) Randomized controlled trial of the
application of topical b-FGF-impregnated gelatin microspheres to improve tissue survival in
subzone II fingertip amputations. J Hand Surg Eur Vol 36: 455-460
160.Liu J, Tabata Y (2011) Effect of modification manner on the photodynamic antitumor activity
of c(60) modified sith pullulan. J Biomater Sciences Polym Eds 22: 2147-2163
161.○ Matsuse D, Kitada M, Ogura F, Wakao S, Kohama M, Kira J, Tabata Y, Dezawa M (2011)
Combined transplantation of bone marrow stromal cell-derived neural progenitor cells with a
collagen sponge and basic fibroblast growth factor releasing microspheres enhances recovery
after cerebral ischemia in rats. Tissue Eng Part A 17: 1993-2004
162.○ Okamaoto T, Saito T, Tabata Y, Uemoto S (2011) Immunological tolerance in a mouse
model of immune-mediated liver injury induced by 16,16 dimethy1 PGE2 and
PGE2-containing nanoscale hydrogels. Biomaterials 32: 4925-4935
163.Origuchi T, Jo J, Hirano Y, Tabata Y (2011) Enhanced tumor imaging efficacy of
5-aminolevulinic acid complexed with iron oxide nanoparticles. International Journal of
Nanotechnology 8: 146-158
164.Ratanavaraporn J, Damrongsakkul S, Kanokpanont S, Yamamoto M, Tabata Y (2011)
Osteogenic differentiation of bone-marrow-derived stem cells cultured with mixed gelatin and
chitooligosaccharide scaffolds. J Biomater Sciences Polym Eds 22: 1083-1098
161
165.○ Ratanavaraporn J, Furuya H, Kohara H, Tabata Y (2011) Synergistic effects of the dual
release of stromal cell-derived factor-1 and bone morphogenetic protein-2 from hydrogels on
bone regeneration. Biomaterials 32: 2797-2811
166.Shi M, Kretlow JD, Spicer PP, Tabata Y, Demian N, Wong ME, Kasper FK, Mikos AG (2011)
Antibiotic-releasing porous polymethylmethacrylate / gelatin / antibiotic constructs for
craniofacial tissue engineering. J Control Release 152: 196-205
167.○ Shiraishi K, Endoh R, Furuhata H, Nishihara M, Suzuki R, Maruyama K, Oda Y, Jo J,
Tabata Y (2011) A facile preparation method of a PFC-containing nano-sized emulsion for
theranostics of solid tumors. Int J Pharm 421: 379-387
168.Tabata Y (2011) Biomaterials design of culture substrates for cell research. Inflammation and
Regeneration 31: 137-145
169.Tadokoro M, Matsushima A, Kotobuki N, Hirose M, Kimura Y, Tabata Y, Hattori K, Ohgushi
H (2011) Bone morphogenetic protein-2 in biodegradable gelatin and β-tricalcium phosphate
sponges enhances the in vivo bone-forming capability of bone marrow mesenchymal stem cells.
J Tissue Eng Regen Med 6: 253-260
170.Takafuji Y, Jo J, Tabata Y (2011) Simple PEG modification of DNA aptamer based on copper
ion coordination for tumor targeting. J Biomater Sciences Polym Eds 22: 1179-1195
171.○ Takagi G, Miyamoto M, Tabata Y, Mizuno K (2011) Therapeutic vascular angiogenesis for
vasculitis related peripheral artery disease. J Vasc Surg 48: 53-60
172.○ Takagi G, Miyamoto M, Tara S, Takagi I, Takano H, Yasutake M, Tabata Y, Mizuno K
(2011) Controlled-release basic fibroblast growth factor for peripheral artery disease:
comparison with autologous bone marrow-derived stem cell transfer. Tissue Eng Part A 17:
2787-2794
173.○ Tanaka K, Nagata D, Hirata Y, Tabata Y, Nagai R, Sata M (2011) Augmented angiogenesis
in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice.
Atherosclerosis 215: 266-273
174.○ Tara S, Takagi G, Miyamoto M, Kirinoki-Ichikawa S, Yamamoto T, Takano H, Takagi I,
Yasutake M, Tabata Y, Mizuno K (2011) Novel approach to ischemic skin ulcer in systemic
lupus erythematosus: Therapeutic angiogenesis by controlled-release basic fibroblast growth
factor. Geriatr Gerontol Int 11: 527-530
162
175.Toda H, Yamamoto M, Kohara H, Tabata Y (2011) Orientation-regulated immobilization of
Jagged1 on glass substrates for ex vivo proliferation of a bone marrow cell population
containing hematopoietic stem cells. Biomaterials 32: 6920-6928
176.○ Watanabe R, Hayashi R, Kimura Y, Tanaka Y, Kageyama T, Hara S, Tabata Y, Nishida K
(2011) A novel gelatin hydrogel carrier sheet for corneal endothelial transplantation. Tissue
Eng Part A 17: 2213-2219
177.○ Eto H, Suga H, Aoi N, Kato H, Doi K, Kuno S, Tabata Y, Yoshimura K (2012) Therapeutic
potential of fibroblast growth factor-2 for hypertrohic scars: upregulation of MMP-1 and HGF
expression. Lab Invest 92: 214-223
178.○ Hussain A, Bessho K, Takahashi K, Tabata Y (2012) Magnesium calcium phosphate as a
novel component enhances mechanical/physical properties of gelatin scaffold and osteogenic
differentiation of bone marrow mesenchymal stem cells. Tissue Eng Part A 18: 768-774
179.○ Kishigami R, Otsu K, Oikawa-Sasaki A, Fujiwara N, Ishizeki K, Tabata Y, Harada H
(2012) Histological analysis of epithelial stem cells during induced pluripotent stem
cell-derived teratoma development. J Oral Biosci 54: 58-65
180.○ Kitamura C, Nishihara T, Terashita M, Tabata Y, Washio A (2012) Local regeneration of
dentin-pulp complex using controlled release of FGF-2 and naturally derived sponge-like
scaffolds. International Journal of Dentistry 2012: 1-8
181.Liu J, Jo J, Kawai Y, Aoki I, Tanaka C, Yamamoto M, Tabata Y (2012) Preparation of
polymer-based multimodal imaging agent to visualize the process of bone regeneration. J
Control Release 157: 398-405
182.Mindemark J, Tabata Y, Bowden T (2012) Low charge density cationic polymers for gene
delivery: Exploring the influence of structural elements on in vitro transfection. Macromol
Biosci 12: 840-848
183.Nakano T, Kaibara K, Ishimoto T, Tabata Y, Umakoshi Y (2012) Biological apatite (BAp)
crystallographic orientation and texture as a new index for assessing the microstructure and
function of bone regenerated by tissue engineering. Bone in press.
184.○ Negoro H, Kanematsu A, Doi M, Suadicani SO, Matsuo M, Imamura M, Okinami T,
Nishikawa N, Oura T, Matsui S, Seo K, Tainaka M, Urabe S, Kiyokage E, Todo T, Okamura H,
Tabata Y, Ogawa O (2012) Involvement of urinary bladder connexin43 and the circadian clock
in coordination of diurnal micturition rhythm. Nat Commun 3: 809
163
185.○ Negoro H, Kanematsu A, Matsuo M, Okamura H, Tabata Y, Ogawa O (2012b)
Development of diurnal micturition pattern in mice after weaning. The Journal of Urology 185:
2398-2404
186.○ Okamoto S, Ikeda T, Sawamura K, Nagae M, Hase H, Mikami Y, Tabata Y, Matsuda K,
Kawata M, Kubo T (2012) Positive effect on Bone fusion by the combination of platelet-rich
plasma and a gelatin β-tricalcium phosphate sponge: A study using a posterolateral fusion
model of lumbar vertebrae in rats. Tissue Eng Part A 18: 157-166
187.Peng LH, Tsang SY, Tabata Y, Gao JQ (2012) Genetically-manipulated adult stem cells as
therapeutic agents and gene delivery vehicle for wound repair and regeneration. J Control
Release 157: 321-330
188.○ Ratanavaraporn J, Furuya H, Tabata Y (2012) Local suppression of pro-inflammatory
cytokines and the effects in BMP-2-induced bone regeneration. Biomaterials 33: 304-316
189.Ratanavaraporn J, Tabata Y (2012) Enhanced osteogenic activity of bone morphogenetic
protein-2 by 2-O-desulfated heparin. Acta Biomater 8: 173-182
190.Saito T, Tabata Y (2012) Preparation of gelatin hydrogels incorporating low-molecular-weight
heparin for anti-fibrotic therapy. Acta Biomater 8: 646-652
191.○ Sakuraba H, Fujiwara N, Sasaki-Oikawa A, Sakano M, Tabata Y, Otsu K, Ishizeki K,
Harada H (2012) Hepatocyte growth factor stimulates root growth during the development of
mouse molar teeth. J Periodontal Res 47: 81-88
192.○ Sekiguchi H, Ii M, Jujo K, Renault MA, Thorne T, Clarke T, Ito A, Tanaka T, Klyachko E,
Tabata Y, Hagiwara N, Losordo D (2012) Estradiol triggers sonic-hedgehog-induced
angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting
protein. Lab Invest 92: 532-542
193.Somamoto S, Tabata Y (2012) An artificial slk-elastin-like protein suppresses cells adhesion
without apoptosis. J Biotechnol Biomater in press
194.Tajima S, Tabata Y (2012) Preparation and functional evaluation of cell aggregates
incorporating gelatin microspheres with different degradabilities. J Tissue Eng Regen Med in
press
195.Takaoka R, Hikasa Y, Hayashi K, Tabata Y (2012) Bone regeneration by lactoferrin released
164
from a gelatin hydrogel. J Biomater Sciences Polym Eds 22: 1581-1589
196.○ Tsuchiya K, Nitta N, Sonoda A, Nitta-Seko A, Ohta S, Takahashi M, Murata K, Mukaisho
K, Shiomi M, Tabata Y, Nohara S (2012) Evaluation of atherosclerotic lesions using dextranand mannan-dextran-coated USPIO: MRI analysis and pathological findings. International
Journal of Nanomedicine 7: 2271-2280
197.Tsuzuki N, Otsuka K, Seo J, Yamada K, Haneda S, Furuoka H, Tabata Y, Sasaki N (2012) In
vivo osteoinductivity of gelatin β-tri-calcium phosphate sponge and bone morphogenetic
protein-2 on an equine third metacarpal bone defect. Res Vet Sci 93: 1021-1025
198.Tsuzuki N, Seo JP, Yamada K, Haneda S, Tabata Y, Sasaki N (2012) Effect of compound of
gelatin hydrogel microsphere incorporated with platelet-rich-plasma and alginate on sole defect
in cattle. J Vet Med Sci in press
199.○ Uesugi Y, Kawata H, Saito Y, Tabata Y (2012) Ultrasound-responsive thrombus treatment
with zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator. J Drug
Target 20: 224-234
200.Yamada H, Mizusawa K, Igarashi R, Tochio H, Shirakawa M, Tabata Y, Kimura Y, Kondo T,
Aoyama Y, Sando S (2012) Substrate/Product-targeted NMR monitoring of pyrimidine
catabolism and its inhibition bhy a clinical drug. ACS Chem Biol 7: 535-542
201.Zhao QQ, Hu YL, Zhou Y, Li N, Han M, Tang GP, Qiu F, Tabata Y, Gao JQ (2012)
Gene-carried hepatoma targeting complex induced high gene transfection efficiency with low
toxicity and significant antitumor activity. Int J Nanomedicine 2012:7: 3191-3202
28) Taira Maekawa
1.
Shimura, K., Ashihara, E., Shimazaki, C., Matsunaga, S., Taniguchi, K., Uchiyama, H.,
Matsumoto, Y., Kimura, S., Matsubara, H., Taniwaki, M., Maekawa, T.: Kinetics of circulating
endothelial progenitors in patients with sclerodermatous chronic graft-versus-host disease. Biol
Blood Marrow Transplant, 14(4):426-437, 2008.
2.
Kuroda, J., Kimura, S., Kamitsuji, Y., Yokota, A., Ashihara, E., Kawata, E., Takeuchi, M.,
Tanaka, R., Tanaka, H., Matsumoto, Y., Andreeff, M., Taniwaki, M., Maekawa, T. : ABT-737 is
a useful component of combinatory chemotherapies for chronic myelogenous leukaemias with
diverse drug resistance mechanisms. Brit J Haematol, 140(2):181-190, 2008.
3.
Deguchi, Y., Kimura, S., Ashihara, E., Niwa, T., Hodohara, K., Fujiyama, Y., Maekawa, T.
165
Comparison of imatinib, dasatinib, nilotinib, and INNO-406 in imatinib-resistant cell lines.
Leuk Res, 32(6):980-983, 2008.
4.
Kuroda, J., Kamitsuji, Y., Kimura, S., Ashihara, E., Nakagawa, Y., Kawata, E., Takeuchi, M.,
Murotani, Y., Yokota, A., Tanaka, R., Andreeff, M., Taniwaki, M., Maekawa, T.: Anti-myeloma
effect of homoharringtonine with concomitant targeting of multiple myeloma-promoting
molecules, Mcl-1, XIAP and β-catenin. Int J Hematol, 87(5):507-515, 2008.
5.
Kitawaki, T., Kadowaki, N., Kondo, T., Ishikawa, T., Ichinohe, T., Teramukai, S., Fukushima,
M., Kasai, Y., Maekawa, T., Uchiyama, T.: Potential of dendritic cell immunotherapy for
relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide- and
keyhole limpet hemocyanin-pulsed, donor-derived dendritic cell vaccine for acute myeloid
leukemia. Am J Hematol. 83(4):315-317, 2008.
6.
Morinaga, K., Yamauchi, T., Kimura, T., Maekawa, T., Ueda, T.: Overcoming imatinib
resistance using Src inhibitor CGP76030, Abl inhibitor nilotinib, and Abl/Lyn inhibitor
INNO-406 in newly established K562 variants with BCR-ABL gene amplification. Int J Cancer,
122(11):2621-2627, 2008.
7.
Tanaka, R., Kuroda, J., Stevenson, W., Ashihara, E., Ishikawa, T., Taki, T., Kobayashi, Y.,
Kamitsuji, Y., Kawata, E., Takeuchi, M., Murotani, Y., Yokota, A., Hirai, M., Majima, S.,
Taniwaki, M., Maekawa, T., Kimura, S.: Detection of the V617F mutation in JAK2 using a
novel, fully automated, SNP super-rapid detector. Leuk Res, 32(9):1462-1467, 2008.
8.
Muramatsu, H., Kimura, S., Ichinohe, T., Ashihara, E., Ishikawa, T., Maekawa, T., Uchiyama,
T. : Consulting clinic for related family donors in hematopoietic stem cell transplantation. Bone
Marrow Transplant, 41(12):1073-1075, 2008.
9.
Kamitsuji, Y., Kuroda, J., Kimura, S., Toyokuni, S., Watanabe, K., Ashihara, E., Tanaka, H.,
Watanabe, M., Matsubara, H., Mizushima, Y., Hiraumi, Y., Kawata, E., Yoshikawa, T.,
Maekawa, T., Nakahata, T., Adachi, S.: Modes of cell death execution and autophagy by
INNO-406, a Bcr-Abl kinase inhibitor, in Bcr-Abl-positive leukemias. Cell Death Diff,
15(11):1712-1722, 2008.
10. Kawata, E., Ashihara, E., Kimura, S., Takenaka, K., Sato, K., Tanaka, R., Yokota, A., Murotani,
Y., Kamitsuji, Y., Takeuchi, M., Kuroda, J., Tanaka, F., Yoshikawa, T., Maekawa, T.:
Administration of PLK-1 siRNA with atelocollagen prevents the growth of liver metastases of
lung cancer. Mol Cancer Therapeutics, 7(9):2904-2912, 2008.
11. Okano, A., Ashihara, E., Shimazaki, C., Uchiyama, H., Inaba, T., Taniguchi, K., Maekawa, T.,
166
Taniwaki, M.: Predictive parameters for granulocyte colony-stimulating factor-induced
peripheral blood stem cell mobilization. J Clin Apher 23(6):171-177, 2008.
12. Yuasa, T., Sato, K., Ashihara, E., Takeuchi, M., Tsuchiya, N., Habuchi, T., Maekawa, T.,
Kimura, S.: Intravesical administration of γδ T cells successfully prevents the growth of
bladder cancer in the murine model. Cancer Immunol Immunother, 58(4):493-502, 2009.
13. Koto, K., Horie, N., Kimura, S., Murata, H., Sakabe, T., Matsui, T., Koto, K., Watanabe, M.,
Adachi, S., Maekawa, T., Fushiki, S., Kubo, T.: Clinical relevant dose of zoledronic acid
inhibits spontaneous lung metastasis in a murine osteosarcoma model. Cancer Lett,
274(2):271-278, 2009.
14. Ashihara, E., Kawata, E., Nakagawa, Y., Shimazaski, C., Kuroda, J., Tanaka, R., Yokota, A.,
Murotani, Y., Takeuchi, M., Kamitsuji, Y., Inaba, T., Taniwaki, M., Kimura, S., Maekawa, T.:
β-catenin siRNA successfully suppressed progression of multiple myeloma in a mouse model.
Clin Cancer Res, 15(8):2731-2738, 2009.
15. Matsumoto, S., Tanaka, F., Sato, K., Kimura, S., Maekawa, T., Hasegawa, S., Wada, H.:
Monitoring with a non-invasive bioluminescent in vivo imaging system of pleural metastasis of
lung carcinoma. Lung Cancer, 66(1):75-9, 2009.
16. Tsubakimoto, Y., Yamada, H., Yokoi, H., Takata, H., Kawahito, H., Matsui, A., Urano, N.,
Nozawa, Y., Hirai, H., Imanishi, J., Ashihara, E., Maekawa, T., Takahashi, T., Okigaki, M.,
Matsubara, H.: Angiotensin AT1 receptor on bone marrow stem cells that regulates
monocyte/macrophage lineage differentiation from hematopoietic stem cell. Arterioscler
Thromb Vasc Biol. 29(10):1529-1536, 2009.
17. Kaido, T., Egawa, H., Tsuji, H., Ashihara, E., Maekawa, T., Uemoto, S.: In-hospital mortality in
adult recipients of living donor liver transplantation: experience of 576 consecutive cases at a
single center. Liver Transpl 15(11):1420-1425, 2009.
18. Takeuchi M, Kimura S, Ashihara E, Maekawa T, Castaner R, Bolos J.: Befetinib. Dual
BCR-ABL/LYN tyrosine kinase inhibitor, INNO-406. Drug Fut. 34(4):261-269, 2009.
19. Matsumoto, S., Tanaka, F., Sato, K,. Kimura, S., Maekawa, T., Hasegawa, S., Wada, H.：
Monitoring with a non-invasive bioluminescent in vivo imaging system of successful treatment
of disseminated pleural tumors by intra-pleural docetaxel administration.
Lung Cancer
66(1):75-79, 2009.
20. Yokota, A., Kimura, S., Tanaka, R., Takeuchi, M., Yao, H., Sakai, K., Nagao, R., Kuroda, J.,
167
Kamitsuji, Y., Kawata, E., Ashihara, E., Maekawa, T.: Osteoclasts are involved in the
maintenance of dormant leukemic cells. Leuk Res. 34; 793-799, 2010.
21. Taniguchi, K., Shimazaki, C., Ochiai, N., Maruya, E., Akatsuka, Y., Ashihara, E., Maekawa, T.,
Taniwaki, M., Saji, H.: Modified elispot assay may predict T-cell hyporesponsiveness to
non-inherited maternal antigens in healthy individuals. Int J Lab Hematol. 32(1 Pt 1):e163-168,
2010.
22. Ohsaka, A., Kikuta, A., Ohto, H., Ohara, A., Ishida, A., Osada, K., Kimitamari, A., Iwai, A.,
Kai, T., Maekawa, T., Hoshi, Y.: Guidelines for safety management of granulocyte transfusion
in Japan. Int J Hematol. 91(2):201-208, 2010.
23. Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Kato T, Matsui A,
Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M,
Matsubara H.: Bone marrow AT1 augments neointima formation by promoting mobilization of
smooth muscle progenitors via platelet-derived SDF-1α Arterioscler Thromb Vasc Biol.
30(1):60-67, 2010.
24. Ashihara, E., Kawata, E., Maekawa, T.: Future prospect of RNA interference for cancer
therapies. Curr Drug Targets. 11(3):345-360, 2010. review
25. ○ Ito, K., Aoyama, T., Fukiage, K., Otsuka, S., Furu, M., Jin, Y., Nasu, A., Ueda, M., Kasai, Y.,
Ashihara, E., Kimura, S., Maekawa, T., Kobayashi, A., Yoshida, S., Niwa, H., Otsuka, T.,
Nakamura, T., Toguchida, J.: A novel method to isolate mesenchymal stem cells from bone
marrow in a closed system using a device made by non-woven fabric. Tissue Eng Part C
Methods 16(1):81-91, 2010.
26. Koto, K., Murata, H., Kimura, S., Horie, N., Matsui, T., Nishigaki, Y., Ryu, K., Sakabe, T., Itoi,
M., Ashihara, E., Maekawa, T., Fushiki, S., Kubo, T.: Zoledronic acid inhibits proliferation of
human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other
anticancer agents. Oncol Rep. 24(1):233-239, 2010.
27. ○ Sekimoto, M., Imanaka, Y., Shirai, T., Sasaki, H., Komeno, T., Lee, J., Yoshihara, K.,
Ashihara, E., Maekawa, T. : Risk-adjusted assessment of incidence and quantity of blood use in
acute-care hospitals in Japan: an analysis using administrative data. Vox Sanguinis, 98:538-546,
2010.
28. Takeuchi, M., Kimura, S., Kuroda, J., Ashihara, E., Kawatani, M., Osada, H., Umezawa, K.,
Yasui, E., Imoto, M., Tsuruo, T., Yokota, A., Tanaka, T., Nagao, R., Nakahata, T., Fujiyama, Y.,
Maekawa, T.: Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring
168
stem-like characteristics in a hypoxic environment. Cell Death Diff, 17(7):1211-1220, 2010.
29. Kamio, N., Hirai, H., Ashihara, E., Tenen, D.G., Maekawa, T., Imanishi, J. : Use of bicistronic
vectors in combination with flow cytometry to screen for effective small interfering RNA target
sequences. Biochem Biophys Res Commun. 393(3):498-503, 2010.
30. Kawata, E., Ashihara,E., Nakagawa, Y., Kiuchi, T., Ogura, M., Yao, H., Sakai, K., Tanaka, R.,
Yokota, A., Takeuchi, M., Kimura, S., Hirai, H., Maekawa, T. : A combination of a
DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant
mesothelioma cells in vitro. Cancer Lett, 294(2):245-253.2010.
31. Tanaka, R., Squires, M.S., Kimura, S., Yokota, A., Mallet, K., Smyth, T., Thompson, N.T.,
Nagao, R., Yamauchi, T., Ashihara, E., Ottmann, O.G., Lyons, J.F., Maekawa, T.: Activity of the
multi-targeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL positive leukemic cells.
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