CV - University of Chicago

Transcription

Curriculum Vitae
Name:
Yusuke Nakamura
Position: Professor, Department of Medicine, Section of Hematology/Oncology
Professor, Department of Surgery
Deputy Director, Center for Personalized Therapeutics
The University of Chicago
th
900E 57 Street KCBD6130
Chicago, IL 60637
Date of Birth:
Nationality:
December 8th, 1952
Japanese
Business Address:
Knapp Center for Biomedical Discovery
th
900 E. 57 Street, KCBD6130
Chicago, IL 60637
Tel: 773-834-1405
e-mail：[email protected]
Education:
Graduated from Osaka University Medical School in March 1977
1977 May
Medical Doctor's License in Japan
1984 August
Ph. D. of molecular genetics from
Osaka University for a thesis entitled: "Sequences of cDNAs for
human salivary and pancreatic alpha-amylases"
Occupation:
1977 May - 1981 March
Second Department of Surgery,
Osaka University School of Medicine
1981 April - 1984 October
Research fellow
Institute for Molecular and Cellular Biology
Osaka University
1984 October - 1988 December
Research Associate
Howard Hughes Medical Institute
University of Utah
1987 September - 1989 August
Research Assistant Professor
Department of Human Genetics
University of Utah
1989 January - 1989 August
Senior Associate
Howard Hughes Medical Institute
University of Utah
1989 April - 1995 March
Head of Biochemistry Department
Cancer Institute, Tokyo
1996 April - 1999 March
Professor, Department of Clinical Genetics
Osaka University School of Medicine
1995 April – 2000 March
Head, Division of Genome Analysis
Cancer Institute, Tokyo
1994 October – 2012 March
Professor, Laboratory of Molecular Medicine
Institute of Medical Science
The University of Tokyo
1995 April – 2011 January
Director, Human Genome Center
Institute of Medical Science
The University of Tokyo
2000 April-2005 March
Group leader for Genotyping
RIKEN SNP Research Center
2005 April-2010 March
Director, RIKEN Center for Genomic Medicine
2011 January-December
Special Advisor to the Cabinet
Secretary General, Office of Medical Innovation, Cabinet Secretariat, Government of Japan
2012 April-present
Professor, Department of Medicine, Section of Hematology/Oncology
Professor, Department of Surgery
Deputy Director, Center for Personalized Therapeutics
Member in the Editorial (or Advisory) Board for
Annals of Human Genetics
Cancer Science (Editor-in-Chief)
Cancer Research (Senior Editor 2004-2007, Deputy Editor 2008-2009)
Cell Cycle
Clinical Genetics
Genes Chromosomes & Cancer
Molecular Cancer Research
International Journal of Oncology
Journal of Human Genetics (Editor-in-Chief 1997-2007)
Neoplasia
Members in
Japan Society of Human Genetics (President, 2007-2010)
Japanese Cancer Association (board member 2002-2013, Preseident for the 2013 annual meeting)
American Association of Cancer Research
American Society of Human Genetics
Science Council of Japan (2005-2012)
Awards
1991
Honorary Citizenship, The State of Maryland, USA
1992
Princess Takamatsu Cancer Research Award
1993
The Research Award of Japanese Foundation for Cancer Research
1995
The Award of the Japanese Society of Human Genetics
1996
Takeda Medical Prize
2000
Keio Medical Science Prize
2002
The Tomizo Yoshida Award of the Japanese Cancer Association
2004
The Medal with a Purple Ribbon (for contributions to education and culture)
2006
Bulgarian Academy of Medical Science, Foreign Member
2010
Chen Award for Distinguished Academic Achievement in Human Genetic and Genomic Research
(HUGO)
2011
Member, Association of American Physicians (AAP)
2011
Honorary Professor, Harbin Medical University
2011
IPIT Award
2013
Honorary Professor, Taipei Medical University
Meeting organizers
2010
JCA-AACR Cancer Conference Co-chairman with Prof. Peter Jones
(at Waikoloa, Hawaii in February 5-9, 2010)
2013
President, 72th JCA (Japan Cancer Association) meeting (at Yokohama in October 3-5, 2013)
Publication
Journal
Total
Am. J. Human Genetics
33
Biochemical and Biophysical Research Communications
16
British Journal of Cancer
13
Cancer
Cancer Research
Cancer Science
Cell
6
114
49
2
Clinical Cancer Research
29
Cytogenetics Cell Genetics
59
Genes Chromosomes and Cancer
44
Genomics
84
Human Genetics
34
Human Molecular Genetics
58
Human Mutation
12
International Journal of Oncology
27
Journal of Clinical Oncology
2
Journal of Human Genetics
124
Lancet
6
Molecular Cell
1
Nature
17
Nature Cell Biology
2
Nature Communications
3
Nature Genetics
68
Neoplasia
12
New Eng. J. Med.
7
Oncogene
51
Oncotarget
1
Pharmacogenetics and Genomics
9
Proc. Natl. Acad. Sci. USA
8
Science
11
Others
424
Total
(At 2014.01.19)
1326
List of papers cited more than 300 times
(at January 20, 2014)
B. Vogelstein, E.R. Fearon, S.R. Hamilton, S. Kern, A.C. Presinger, M. Leppert,
Y. Nakamura, R. White, L. Smets and J.L. Bos: Genetic alterations during
colorectal tumor development. New Eng. J. Med., 319:525-532, 1988
The International HapMap Consortium: A haplotype map of the human genome.
Nature, 437:1299-1320, 2005
The International HapMap Consortium: The International HapMap Project.
Nature, 426:789-796, 2003
The International HapMap Consortium: A second generation human haplotype
map of over 3.1 million SNPs. Nature, 449:851-861, 2007
K.W. Kinzler, M.C. Nilbert, L. Su, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J.
Smith, A.C. Preisinger, P. Hedge, D. McKechnie, R. Finniear, A. Markham, J.
Groffen, M.S. Boguski, S.F. Alschul, A. Horii, H. Ando, Y. Miyoshi, Y. Miki, I.
Nishisho, Y. Nakamura: Identification of FAP locus genes from chromosome
5q21. Science, 253:661-665, 1991
Y. Nakamura, M. Leppert, P. O'Connell, Roger Wolff, T. Holm, M. Culver, C.
Martin, E. Fujimoto, M. Hoff, E. Kumlin and R. White: Variable number of tandem
repeat (VNTR) markers for human gene mapping. Science, 235:1616-1622, 1987
5378
S.J. Baker, E.R. Fearon, J.M. Nigro, S.R. Hamilton, A.C. Preisinger, J.M. Jessup,
P. vanTuinen, D.H. Ledbetter, D.F. Barker, Y. Nakamura, R. White and B.
Vogelstein: Chromosome 17 Deletions and p53 mutations in Colorectal
Carcinomas. Science, 244:217-221, 1989
I. Nishisho, Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J.
Utsunomiya, S. Baba, P. Hedge, A. Markham, A.J. Krush, G. Petersen, S.R.
Hamilton, M.C. Nilbert, D.B. Levy, T.M. Bryan, A.C. Preisinger, K.J. Smith, L. Su,
K.W. Kinzler, and B. Vogelstein: Mutations of chromosome 5q21 genes in FAP
and colorectal cancer patients. Science, 253:665-669, 1991
B. Vogelstein, E.R. Fearon, S.E. Kern, S.R. Hamilton, A.C. Preisinger, Y.
Nakamura and R. White: Allelotype of colorectal carcinomas. Science,
244:207-211, 1989
K. Oda, H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori,
K. Tamai, T. Tokino, Y. Nakamura, and Y. Taya: p53AIP1, a potential mediator of
p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell,
102:849-862, 2000
C. Larsson, B. Skogseid, K. Obeg, Y. Nakamura, M. Nordenskjold: Multiple
endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in
insulinoma. Nature, 332:85-87, 1988
A. Suzuki, R. Yamada, X. Chang, S.Tokuhiro, T. Sawada, M. Suzuki, M.
Nagasaki, M. Nakayama-Hamada, R.Kawaida, M. Ono, M. Ohtsuki, H. Furukawa,
S. Yoshino, M. Yukioka, S. Touma, T. Matsubara, S. Wakitani, R. Teshima, A.
Sekine, A.Iida, A. Takahashi, T. Tsunoda, Y. Nakamura, and K. Yamamoto:
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine
deiminase 4, are associated with rheumatoid arthritis. Nature Genetics,
34:395-402, 2003
Y. Miyoshi, H. Nagase, H. Ando, A. Horii, S. Ichii, S. Nakatsuru, T. Aoki, Y. Miki,
T. Mori and Y. Nakamura: Somatic mutation of the APC gene in colorectal
tumors: mutation cluster region in the APC gene. Human Molecular Genetics,
1:229-233, 1992
S. Satoh, Y. Daigo, Y. Furukawa, T. Katoh, N. Miwa, T. Nishiwaki, T. Kawasoe, H.
Ishiguro, M. Fujita, T. Tokino, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, Y.
Yamaoka, and Y. Nakamura: AXIN1 mutations in hepatocellular carcinomas, and
growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature
Genetics, 24:245-250, 2000
The International Warfarin Pharmacogenetics Consortium: Estimation of the
warfarin dose with clinical and pharmacogenetic data. New Eng. J. Med.,
360:753-764, 2009
1672
2911
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1700
1449
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868
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766
764
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K. Ozaki, Y. Ohnishi, A. Iida, A. Sekine, R. Yamada, T. Tsunoda, H. Sato, H.
Sato, M. Hori, Y. Nakamura, and T. Tanaka: Functional SNPs in the
lymphotoxin-α gene that are associated with susceptibility to myocardial
infarction. Nature Genetics, 32:650-654, 2002
H. Tanaka, H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, K. Matsui, Y.
Takei, and Y. Nakamura: A ribonucleotide reductase gene involved in a
p53-dependent cell-cycle checkpoint DNA damage. Nature, 404:42-49, 2000
698
D. Barker, E. Wright, K. Nguyen, L. Cannon, P. Fain, D. Goldger, D. T. Bishop, J.
Carey, B. Bety, H. Willard, J. S. Waye, G. Greig, L. Leinward, Y. Nakamura, P.
O'Connell, M. Leppert, J.-M. Lalouel, R. White and M. Skolnick: Gene for von
Recklinghausen neurofibromatosis is in the pericentromeric region of
chromosome 17. Science, 236:1100-1102, 1987
K.W. Kinzler, M.C. Nilbert, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C.
Preisinger, S.R. Hamilton, P. Hedge, A. Merkham, M. Carlson, G. Joslyn, J.
Groden, R. White, Y. Miki, I. Nishisho and Y. Nakamura: Identification of a gene
located at chromosome 5q21 that is mutated in colorectal cancers. Science,
251:1366-1370, 1991
M. Leppert, M. Dobbes, P. Scambler, P. O'Connell, Y. Nakamura, D. Stauffer, S.
Woodward, R. Burt, J. Hughes, E. Gardner, M. Lathrop, J. Wasumuth, J.-M.
Lalouel, R. White: The gene for familial polyposis coli maps to the long arm of
chromosome 5. Science, 238:1411-1413, 1987
K. Kobayashi, Y. Nakahori, M. Miyake, Y. Nomura, M. Yoshioka, K. Saito, M.
Osawa, J. Goto, Y. Nakagome, I. Kanazawa, Y. Nakamura, K. Tokunaga, and T.
Toda: An ancient retrotransposal insertion causes Fukuyama-type congenital
muscular dystrophy (FCMD). Nature, 394:388-392, 1998
643
R.A. Gatti, I. Berkel, E. Border, G. Braedt, P. Charmley, P. Concannon, F. Ersoy,
T. Foroud, N.J.G. Jaspers, K. Lange, G.M. Lathrop, M. Leppert, Y. Nakamura, M.
Paterson, W. Salser, O. Sanal, W. Shan, J. Silver, R.S. Sparkes, E. Susi, D.
Weeks, R. White and F. Yoder: Localization of ataxia-telangiectasia gene to
chromosome 11q22.3. Nature, 336:577-580, 1988
H. Okabe, S. Satoh, T. Kato, O. Kitahara, R. Yanagawa, Y. Yamaoka, T.
Tsunoda, Y. Furukawa and Y. Nakamura: Genome-wide analysis of gene
expression in human hepatocellular carcinomas using cDNA microarray:
identification of genes involved in viral carcinogenesis and tumor progression.
Cancer Research, 6:2129-2137, 2001
P. C. Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, X. Xie, E.
H. Byrne, S. A. McCarroll, R. Gaudet, S. F. Schaffner, E. S. Lander, and The
International HapMap Consortium: Genome-wide detection and characterization
of positive selection in human populations. Nature, 449:913-918, 2007
555
T. Sato, A. Tanigami, K. Yamakawa, F. Akiyama, F. Kasumi, G. Sakamoto and Y.
Nakamura: Allelotype of breast cancer: Cumulative allele losses promote tumor
progression in primary breast cancer. Cancer Research, 50:7184-7189, 1990
493
H. Han, A. Yanagisawa, Y. Kato, J. Park, and Y. Nakamura: Genetic instability in
pancreatic cancer and poorly differentiated type of gastric cancer. Cancer
Research, 53:5087-5089, 1993
S. Tokuhiro, R. Yamada, X. Chang, A. Suzuki, Y. Kochi, T. Sawada, M. Suzuki,
M. Nagasaki, M. Ohtsuki, M. Ono, H. Furukawa, M. Nagashima, S. Yoshino, A.
Mabuchi, A. Sekine, S. Saito, A. Takahashi, T. Tsunoda, Y. Nakamura and K.
Yamamoto: An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an
organic cation transporter, is associated with rheumatoid arthritis. Nature
Genetics, 35:341-348, 2003
W. Satake, Y. Nakabayashi, I. Mizuta, Y. Hirota, C. Ito, M. Kubo, T. Kawaguchi, T.
Tsunoda, M. Watanabe, A. Takeda, H. Tomiyama, K. Nakashima, K. Hasegawa,
F. Obata, T. Yoshikawa, H. Kawakami, S. Sakoda, M. Yamamoto, N. Hattori, M.
Murata, Y. Nakamura, and T. Toda: Genome-wide association study identifies
common variants at four loci as genetic risk factors for Parkinson's disease.
Nature Genetics, 41:1303-1307, 2009
485
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643
592
575
507
504
471
466
Y. Miyoshi, H. Ando, H. Nagase, I. Nishisho, A. Horii, Y. Miki, T. Mori, J.
Utsunomiya, S. Baba, G. Petersen, S.R. Hamilton, K.W. Kinzler, B. Vogelstein, Y.
Nakamura: Germ-line mutations of the APC gene in 53 familial adenomatous
polyposis patients. Proc. Natl. Acad. Sci. USA, 89:4452-4456, 1992
The International Cancer Genome Consortium: International network of cancer
genome projects. Nature, 464:993-998, 2010
T. Mizuguchi, G. Collod-Beroud, T. Akiyama, M. Abifadel, N. Harada, T. Morisaki,
D. Allard, M. Varret, M. Claustres, H. Morisaki, M. Ihara, A. Kinoshita, K.
Yoshiura, C. Junien, T. Kajii, G. Jondeau, T. Ohta, T. Kishino, Y. Furukawa, Y.
Nakamura, N. Niikawa, C. Boileau, and N. Matsumoto: Heterozygous TGFBR2
mutations in Marfan syndrome. Nature Genetics, 36:855-860, 2004
Y. Miyoshi, K. Iwao, Y. Nagasawa, T. Aihara, Y. Sasaki, S. Imaoka, M. Murata,
T. Shimano, and Y. Nakamura: Activation of the beta-catenin gene in primary
hepatocellular carcinomas by somatic alterations involving exon 3. Cancer
Research, 58:2524-2527, 1998
K. Yasuda, K. Miyake, Y. Horikawa, K. Hara, H. Osawa, H. Furuta, Y. Hirota, H.
Mori, A. Jonsson, Y. Sato, K. Yamagata, Y. Hinokio, H.-Y. Wang, T. Tanahashi,
N. Nakamura, Y. Oka, N. Iwasaki, Y. Iwamoto, Y. Yamada, Y. Seino, H.
Maegawa, A. Kashiwagi, J. Takeda, E. Maeda, H. D. Shin, Y. M. Cho, K. S. Park,
H. K. Lee, M. C. Y. Ng, R. C. W. Ma, W.-Y. So, J. C. N. Chan, V. Lyssenko, T.
Tuomi, P.Nilsson, L. Groop, N. Kamatani, A. Sekine, Y. Nakamura, K. Yamamoto,
T. Yoshida, K. Tokunaga, M. Itakura, H. Makino, K. Nanjo, T. Kadowaki, and M.
Kasuga: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes
mellitus. Nature Genetics, 40:1092-1097, 2008
R. Hamamoto, Y. Furukawa, M. Morita, Y. Iimura, F. P. Silva, M. Li, R. Yagyu and
Y. Nakamura: SMYD3 encodes a novel histone methyltransferase involved in
the proliferation of cancer cells. Nature Cell Biology, 6:731-740, 2004
S. Kern, E. Fearon, K.W.F. Tersmette, J.P. Enterline, M. Leppert, Y. Nakamura,
R. White, B. Vogelstein and S. Hamilton: Allelic loss in colorectal carcinoma.
JAMA, 261:3099-3103, 1989
K. Kasai, Y. Nakamura and R. White: Amplification of a VNTR locus (pMCT118)
by the polymerase chain reaction (PCR) and its application to forensic science. J.
Forensic Sci., 35:1196-1200, 1990
M. Leppert, E. Anderson, T. Quattlebaum, D. Stauffer, P. O'Connell, Y.
Nakamura, J-M. Lalouel and R. White: Mapping of the seizure gene: Benign
familial neonatal convulsions linked to genetic makers on chromosome 20.
Nature, 337:647-648, 1989
N. Hayashi, I. Ito, A. Yanagisawa, Y. Kato, S. Nakamori, S. Imaoka, H. Watanabe,
M. Ogawa, and Y. Nakamura: Genetic diagnosis of lymph-node metastasis in
colorectal cancer. Lancet, 345:1257-1259, 1995
H. Unoki, A. Takahashi, T. Kawaguchi, K. Hara, M. Horikoshi, G. Andersen,
D.P.K. Ng, J. Holmkvist, K. Borch-Johnsen, T. J. Rgensen, A. Sandbaek, T.
Lauritzen, T. Hansen, S. Nurbaya, T. Tsunoda, M. Kubo, T. Babazono, H. Hirose,
M. Hayashi, Y. Iwamoto, A. Kashiwagi, K. Kaku, R. Kawamori, E. S. Tai, O.
Pedersen, N. Kamatani, T. Kadowaki, R. Kikkawa, Y. Nakamura, and S. Maeda:
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East
Asian and European populations. Nature Genetics, 40:1098-1102, 2008
450
W. Cookson, R.P. Young, A.J. Sandford, M.F. Moffatt, T. Shirakawa, P.A. Sharp,
J.A. Faux, C. Julier, R.A. Wells, P.N. Le Souef, Y. Nakamura, G.M. Lathrop and
J.M. Hopkin: Maternal inheritance of atopic IgE responsiveness on chromosome
11q. Lancet, 340:381-384, 1992
K. Ono, T. Tanaka, T. Tsunoda, O. Kitahara, C. Kihara, A. Okamoto, K. Ochiai, T.
Takagi, and Y. Nakamura: Identification by cDNA microarray of genes Involved in
ovarian carcinogenesis. Cancer Research, 60:5007-5011, 2000
356
H. Nagase, and Y. Nakamura: Mutations of the APC (adenomatous polyposis
coli) gene. Human Mutation, 2:425-434, 1993
355
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387
386
381
380
377
371
359
356
H. Shibata, K. Toyama, H. Shioya, M. Ito, M. Hirota, S. Hasegawa, H. Matsumoto,
H. Takano, T. Akiyama, K. Toyoshima, R. Kanamaru, Y. Kanegae, I. Saito, Y.
Nakamura, K. Shiba, and T. Noda: Rapid colorectal adenoma formation initiated
by conditional targeting of the APC gene. Science, 278:120-123, 1997
343
A. Tenesa, S.M. Farrington, J.G.D. Prendergast, M.E. Porteous, M. Walker, N.
Haq, R.A. Barnetson, E. Theodoratou, R. Cetnarskyj, N. Cartwright, R. Wilson, C.
Semple, A.J. Clarke, F.J.L. Reid, L.A. Smith, K. Kavoussanakis, T. Kossler,
P.D.P. Pharoah, S. Buch, C. Schafmayer, J. Tepel, S. Schreiber, H. Volzke, C.O.
Schmidt, J. Hampe, S. Wilkening, F. Canzian, J. Chang-Claude, M. Hoffmeister,
H. Brenner, G. Capella, V. Moreno, I.J. Deary, J.M. Starr, I.P.M. Tomlinson, E.
Webb, R.S. Houlston, G. Rennert, D. Ballinger, L. Rozek, S.B. Gruber, K.
Matsuda, T. Kidokoro, Y. Nakamura, B.W. Zanke, C.M.T. Greenwood, J. Rangrej,
R. Kustra, A. Montpetit, T.J. Hudson, S. Gallinger, H. Campbell, and M.G. Dunlop:
A genome-wide association scan identifies colorectal cancer susceptibility locus
on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics,
40:631-637, 2008
T. Mori, K. Miura, T. Aoki, T. Nishihira, S. Mori, and Y. Nakamura: Frequent
somatic mutation of the MTS1/CDK4I (multiple tumor
suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous
cell carcinoma. Cancer Research, 54:3396-3397, 1994
Y. Horio, Ta. Takahashi, T. Kuroishi, K. Hibi, M. Suyama, T. Niimi, K. Shimokata,
K. Yamakawa, Y. Nakamura, R. Ueda, and To. Takahashi: Prognostic
significance of p53 mutation and 3p deletion in primary resected non-small cell
lung cancer. Cancer Research, 53:1-4, 1993
Y. Ohnishi, T. Tanaka, K. Ozaki, R. Yamada, H. Suzuki and Y. Nakamura: A
high-throughput SNP typing system for genome-wide association studies. Journal
of Human Genetics, 46:471-477, 2001
A.J. Sandford, T. Shirakawa, M.F. Moffatt, S.E. Daniels, C. Ra, J.A. Faux, R.P.
Young, Y. Nakamura, G.M. Lathrop, W. Cookson and J.M. Hopkin: Localization of
atopy and the βsubunit of high-affinity IgE receptor (FcERI) on chromosome
11q. Lancet, 341:332-334, 1993
M.H. Jones and Y. Nakamura: Detection of loss of heterozygosity at the human
tp53 locus using a dinucleotide repeat polymorphism. Genes Chromosomes and
Cancer, 5:89-90, 1992
O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, E. M.
Nita, H. Ogasawara, J. Okutsu, H. Zenbutsu, N. Shiraishi, T. Takagi, Y.
Nakamura, and T. Tsunoda: Alterations of gene expression during colorectal
carcinogenesis revealed by cDNA microarrays after laser-capture microdissection
of tumor tissues and normal epithelia. Cancer Research, 61:3544-3549, 2001
Y. Miki, I. Nishisho, A. Horii, Y. Miyoshi, J. Utsunomiya, K. Kinzler, B. Vogelstein.
Y. Nakamura: Disruption of the APC gene by retrotransposal insertion of L1
sequence in a colon cancer. Cancer Research, 52:643-645, 1992
H. Nagase, Y. Miyoshi, A. Horii, T. Aoki, M. Ogawa, J. Utsunomiya, S. Baba, T.
Sasazuki and Y. Nakamura: Correlation between the location of germ-line
mutations in the APC gene and the number of colorectal polyps in familial
adenomatous polyposis (FAP) patients. Cancer Research, 52:4055-4057, 1992
A. Bourdon, L. Minai, V. Serre, J.-P. Jais, E. Sarzi, S. Aubert, D. Chretien, P. de
Lonlay, V. Paquis-Flucklinger, H. Arakawa, Y. Nakamura, A. Munnich, and A.
Rotig: Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase
(p53R2), causes severe mitochondrial DNA depletion. Nature Genetics,
39:776-780, 2007
342
Total number of citations of all papers：>100,000
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300
Publication lists:
1.
Y. Miyake, Y. Nakamura, N. Takayama and K. Horiike: Alpha reduced nicotinamide adenine
dinucleotides-dependent reductase reactions of rat liver microsomes. Journal of Biochem.,
78:773-783, 1975
2.
T. Noguchi, H. Inoue, Y. Nakamura, H. Chen, K. Matsubara and T. Tanaka: Molecular cloning of
cDNA sequences for rat M2-type pyruvate kinase and regulation of its mRNA. Journal of
Biological Chemistry, 259:2651-2655, 1984
3.
Y. Nakamura, M. Ogawa, T. Nishide, M. Emi, S. Himeno, G. Kosaki and K. Matsubara:
Sequences of cDNAs for human salivary and pancreatic alpha-amylase. Gene, 28:263-270, 1984
4.
K. Ishizaki, A. Noda, M. Ikenaga, K. Ida, K. Omoto, Y. Nakamura and K. Matsubara: Restriction
fragment length polymorphism detected by human salivary amylase cDNA. Human Genetics,
71:261-262, 1985
5.
T. Yamamoto, Y. Nakamura, T. Nishide, M. Emi, M. Ogawa, T. Mori and K. Matsubara: Molecular
cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA.
Biochemical and Biophysical Research Communications, 132:605-612, 1985
6.
R. White, S. Woodward, M. Leppert, P. O'Connell, Y. Nakamura, M. Hoff, J. Herbst, J-M. Lalouel,
M. Dean and G. Vande Woude: A closely linked genetic marker for cystic fibrosis. Nature,
318:382-384, 1985
7.
T. Nishide, Y. Nakamura, M. Emi, T. Yamamoto, M. Ogawa, T. Mori and K. Matsubara: Primary
structure of human salivary alpha-amylase gene. Gene, 41:299-304, 1986
8.
M. Emi, Y. Nakamura, M. Ogawa, T. Yamamoto, T. Nishide, T. Mori and K. Matsubara: Cloning,
characterization and nucleotide sequences of two cDNAs encoding human pancreatic
trypsinogens. Gene, 41:305-310, 1986
9.
R. White, Y. Nakamura, C. Julier, A. Silva, P. O'Connell, M. Leppert, M. Lathrop and J.-M.
Lalouel: Linkage Maps of Human Chromosomes. Current Communications in Molecular Biology
"DNA Probes", :43-47, 1986
10. R. White, M. Leppert, P. O'Connell, Y. Nakamura, C. Julier, S. Woodward, A. Silva, R. Wolff, M.
Lathrop and J.-M. Lalouel: Construction of Human Genetic Linkage Maps: I. Progress and
perspectives. Cold Spring Harbor Symposia on Quantitative Biology Volume 51: Molecular
Biology of Homo Sapiens, 51:29-38, 1986
11. Y. Nakamura, T. Sato, M. Emi, A. Miyanohara, T. Nishide and K. Matsubara: Expression of
human salivary alpha-amylase gene in Saccharomyces cervisiae and its secretion using the
mammalian signal sequence. Gene, 50:239-245, 1986
12. T. Sato, S. Tsunasawa, Y. Nakamura, M. Emi, F. Sakiyama and K. Matsubara: Expression of the
human salivary alpha-amylase gene in yeast and characterization of the secreted protein. Gene,
50:247-257, 1986
13. R. White, M. Leppert, P. O'Connell, Y. Nakamura, S. Woodward, M. Hoff, J. Herbst, M. Dean, G.
Vande Woude, M. Lathrop and J.-M. Lalouel: Further linkage data on cystic fibrosis: the Utah
study. Am. J. Human Genetics, 39:694-698, 1986
14. Y. Nakamura, M. Leppert, P. O'Connell, Roger Wolff, T. Holm, M. Culver, C. Martin, E. Fujimoto,
M. Hoff, E. Kumlin and R. White: Variable number of tandem repeat (VNTR) markers for human
gene mapping. Science, 235:1616-1622, 1987
15. Y. Nakamura, C. Julier, R. Wolff, T. Holm, P. O'Connell, M. Leppert and R. White:
Characterization of human "midisatellite" sequence. Nucleic Acids Research, 15:2537-2547,
1987
16. L. D. Keppen, M. F. Leppert, P. O'Connell, Y. Nakamura, D. Stauffer, M. Lathrop, J-M. Lalouel
and R. White: Etiological heterogeneity in X-linked spastic paraplesia. Am. J. Human Genetics,
41:933-943, 1987
17. R. White, M. Leppert, P. O'Connell, Y. Nakamura, T. Holm, G.M. Lathrop and J-M. Lalouel:
Linkage maps of human genes. Acuta Paediatrica Japonica, 29:482-488, 1987
18. D. Barker, E. Wright, K. Nguyen, L. Cannon, P. Fain, D. Goldger, D. T. Bishop, J. Carey, B. Bety,
H. Willard, J. S. Waye, G. Greig, L. Leinward, Y. Nakamura, P. O'Connell, M. Leppert, J.-M.
Lalouel, R. White and M. Skolnick: Gene for von Recklinghausen neurofibromatosis is in the
pericentromeric region of chromosome 17. Science, 236:1100-1102, 1987
19. P. O'Connell, G.M. Lathrop, M. Law, M. Leppert, Y. Nakamura, M. Hoff, E. Kumlin, W. Thomas, T.
Elsner, L. Ballard, P. Goodman, E. Azen, J.E. Sadler, G.Y. Cai, J.-M. Lalouel and R. White: A
primary genetic linkage map for human chromosome 12. Genomics, 1:93-102, 1987
20. M. Leppert, M. Dobbes, P. Scambler, P. O'Connell, Y. Nakamura, D. Stauffer, S. Woodward, R.
Burt, J. Hughes, E. Gardner, M. Lathrop, J. Wasumuth, J.-M. Lalouel, R. White: The gene for
familial polyposis coli maps to the long arm of chromosome 5. Science, 238:1411-1413, 1987
21. R. White, Y. Nakamura, P. O'Connell, M. Leppert, M. Lathrop, J.-M. Lalouel, D. Barker, D.
Goldgar, M. Skolnick, C. Mathew and B. Ponder: Tightly linked markers for the neurofibromatosis
type1 gene. Genomics, 1:364-367, 1987
22. P. O'Connell, M. Leppert, Y. Nakamura, M. Dean, M. Park, G.V. Woude, M. Ferrall, B. Wainright,
R. Williamson, M. Lathrop, J.-M. Lalouel and R. White: DNA markers for the cystic fibrosis locus.
Genetics and Epithelial Cell Dysfunction in Cystic Fibrosis, Alan R. Liss Inc., :127-137, 1987
23. R.L. White, J.-M. Lalouel, G.M. Lathrop, M.F. Leppert, Y. Nakamura, and P. O’Connell: Mapping
approaches to gene identification in humans. Western Journal of Medicine, 147:423-427, 1987
24. G.M. Lathrop, M. Farrall, P. O'Connell, M. Leppert, Y. Nakamura, N. Lench, H. Kruyer, M. Dean,
M. Park, G. Vande Woude, J.-M. Lalouel, R. Williamson, R. White: Refined linkage map of
chromosome 7 in the region of cystic fibrosis gene. Am. J. Human Genetics, 42:38-44, 1988
25. M. Lathrop, Y. Nakamura, P. Cartwright, P. O'Connell, M. Leppert, C. Jones, H. Tateishi, T. Bragg,
J.M. Lalouel and R. White: A primary genetic map of markers for human chromosome 10.
Genomics, 2:157-164, 1988
26. C. Larsson, B. Skogseid, K. Obeg, Y. Nakamura, M. Nordenskjold: Multiple endocrine neoplasia
type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature, 332:85-87, 1988
27. Y. Nakamura, M. Lathrop, M. Leppert, M. Dobbes, J. Wasumuth, E. Wolff, M. Carlson, E.
Fujimoto, K. Krapcho, S. Woodward, R. Burt, J. Hughes, E. Gardner, J.-M. Lalouel and R. White:
Localization of the genetic defect in familial adenomatous polyposis within a small region of
chromosome 5. Am. J. Human Genetics, 43:638-644, 1988
28. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, D. Barker, E. Wright, M. Skolnick, S.
Kondoleon, M. Litt, J.-M. Lalouel and R. White: A mapped set of DNA markers for human
chromosome 17. Genomics, 2:302-309, 1988
29. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, J.-M. Lalouel and R. White: A primary map of
10 DNA markers and 2 serological markers for human chromosome 19. Genomics, 3:67-71, 1988
30. R.A. Lothe, Y. Nakamura, S. Woodward, T. Gedde-Dahl and R. White: VNTR(variable number of
tandem repeats) markers show loss of chromosome 17p sequences in human colorectal
carcinomas. Cytogenetics Cell Genetics, 48:167-169, 1988
31. B. Vogelstein, E.R. Fearon, S.R. Hamilton, S. Kern, A.C. Presinger, M. Leppert, Y. Nakamura, R.
White, L. Smets and J.L. Bos: Genetic alterations during colorectal tumor development. New
Eng. J. Med., 319:525-532, 1988
32. S. Chamberlain, J. Shaw, A. Rowland, J. Wallis, S. South, Y. Nakamura, A. von Gabain, M.
Farrall and R. Williamson: Mapping of mutation causing Friedrich's ataxia to human chromosome
9. Nature, 334:248-250, 1988
33. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, J.-M. Lalouel and R. White: A mapped set of
markers for human chromosome 15. Genomics, 3:342-346, 1988
34. Y. Nakamura, M. Carlson, K. Krapcho, M. Kanamori and R. White: A new approach for isolating
VNTR markers. Am. J. Human Genetics, 43:854-859, 1988
35. Y. Nakamura, M. Lathrop, T. Bragg, C. Jones, P. O'Connell, M. Leppert, J.-M. Lalouel and R.
White: An extended linkage map for human chromosome 10. Genomics, 3:389-392, 1988
36. M. Lathrop, Y. Nakamura, P. O'Connell, M. Leppert, S. Woodward, J.-M. Lalouel and R. White: A
mapped set of genetic markers for human chromosome 9. Genomics, 3:361-366, 1988
37. R.A. Gatti, I. Berkel, E. Border, G. Braedt, P. Charmley, P. Concannon, F. Ersoy, T. Foroud,
N.J.G. Jaspers, K. Lange, G.M. Lathrop, M. Leppert, Y. Nakamura, M. Paterson, W. Salser, O.
Sanal, W. Shan, J. Silver, R.S. Sparkes, E. Susi, D. Weeks, R. White and F. Yoder: Localization
of ataxia-telangiectasia gene to chromosome 11q22.3. Nature, 336:577-580, 1988
38. P. vanTuinen, W. B. Dobyns, D. C. Rich, K. M. Summers, T. J. Robinson, Y. Nakamura and D.
Ledbetter: Molecular detection of microscopic and submicroscopic deletions associated with
Miller-Dieker syndrome. Am. J. Human Genetics, 43:587-596, 1988
39. R. Wolff, Y. Nakamura and R. White: Molecular characterization of a spontaneously generated
new allele at a VNTR locus. Genomics, 3:347-351, 1988
40. P. O'Connell, M. Lathrop, M. Leppert, Y. Nakamura, U. Muller, J.-M. Lalouel and R White: Twelve
loci form a continuous linkage map for human chromosome 18. Genomics, 3:367-372, 1988
41. P. O'Connell, G.M. Lathrop, Y. Nakamura, M.L. Leppert, R.H. Ardinger, J.L. Murray, J-M. Lalouel
and R. White: Twenty-eight loci form a continuous linkage map of markers for human
42. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, J.M. Lalouel and R. White: Frequent
recombination was observed in the distal end of the long arm of human chromosome 14.
Genomics, 4:76-81, 1989
43. R. Fujita, A. Seck, Y. Agid, C. Tommasi-Davenas, P. Trouillas, A. J. Driesel, K. Olek, Y.
Nakamura, J. L. Mandel and A. Hanauer: Confirmation of linkage of Friedrich ataxia to
chromosome 9 and identification of a new closely linked marker. Genomics, 4:110-111, 1989
44. W. Byerley, J.-M. Lalouel, C. Mellon, Y. Nakamura, P. O'Connell, M. Leppert and R. White:
Mapping genes for manic-depression and schizophrenia with DNA markers. Neuroscience,
12:46-48, 1989
45. R.M. Landsvater, C.P.G. Mathew, B.A. Smith, E.M. Marcus, G.J. te Meerman, C.J.M. Lips, R.A.
Geerink, Y. Nakamura, B.A.J. Ponder, C.H.C.M. Buys: Development of multiple endocrine
neoplasia type 2A does not involve substantial deletions of chromosome 10. Genomics,
4:246-250, 1989
46. J. Toguchida, K. Ishizaki, M.S. Sasaki, Y. Nakamura, M. Ikenaga, M. Kato, M. Sugimoto, Y.
Kotoura and T. Yamamoto: Preferential mutation of paternally derived RB gene as the initial event
in sporadic osteosarcoma. Nature, 338:156-158, 1989
47. M. Fujimoto, D. Fults, G. Thomas, Y. Nakamura, M. P. Heilbrun, R. White, J. L. Story, S. L. Naylor,
K. S. Kagen-Hallet and P. J. Sheridan: Loss of heterozygosity on chromosome 10 in human
glioblastoma multiforme. Genomics, 4:210-214, 1989
48. M. Leppert, E. Anderson, T. Quattlebaum, D. Stauffer, P. O'Connell, Y. Nakamura, J-M. Lalouel
and R. White: Mapping of the seizure gene: Benign familial neonatal convulsions linked to genetic
makers on chromosome 20. Nature, 337:647-648, 1989
49. Y. Nakamura, C.P.G. Mathew, H. Sobol, D.F. Easton, H. Telenius, T. Bragg, K. Chin, J. Clark, C.
Jones, G.M. Lonoir, R. White and B.A.J. Ponder: Linked markers flanking the gene for multiple
endocrine neoplasia type 2A. Genomics, 5:199-203, 1989
50. Y. Nakamura, N. Tomita, T. Nishide, M. Emi, A. Horii, M. Ogawa, T. Mori, G. Kosaki, T. Okabe, M.
Fujisawa, N. Ohsawa, T. Kameya and K. Matsubara: Production of salivary type alpha-amylase in
human lung cancer. Gene, 77:107-112, 1989
51. K. Tory, H. Brauch, M. Linehan, E. Oldfield, D. Barba, M. Filling-Katz, Y. Nakamura, R. White, B.
Seizinger, M.I. Lerman and B. Zbar: Specific genetic change in tumors associated with von
Hippel-Lindau disease. J. Natl. Cancer Inst., 81:1097-1101, 1989
52. Y. Nakamura, C. Larsson, C. Julier, B. Skogseid, S. Wells, K. Oberg, M. Carlson, P. O'Connell, M.
Leppert, J.-M. Lalouel, M. Nordenskjold and R. White: Localization of the genetic defect in
multiple endocrine neoplasia type 1 within a small region of chromosome 11. Am. J. Human
Genetics, 44:751-755, 1989
53. L.A. Lothe, S.D. Fossa, A.E. Stenwig, Y. Nakamura, R. White, A.-L. Borresen and A. Brogger:
Loss of 3P or 11 alleles is associated with testicular tumors. Genomics, 5:134-138, 1989
54. B. Vogelstein, E.R. Fearon, S.E. Kern, S.R. Hamilton, A.C. Preisinger, Y. Nakamura and R.
White: Allelotype of colorectal carcinomas. Science, 244:207-211, 1989
55. S.J. Baker, E.R. Fearon, J.M. Nigro, S.R. Hamilton, A.C. Preisinger, J.M. Jessup, P. vanTuinen,
D.H. Ledbetter, D.F. Barker, Y. Nakamura, R. White and B. Vogelstein: Chromosome 17
Deletions and p53 mutations in Colorectal Carcinomas. Science, 244:217-221, 1989
56. P. O'Connell, G.M. Lathrop, Y. Nakamura, M.L. Leppert, J.-M. Lalouel and R. White: Twenty loci
form a continuous linkage map of markers for human chromosome 2. Genomics, 5:738-745, 1989
57. G.M. Lathrop, P. O'Connell, M. Leppert, Y. Nakamura, M. Farrall, L.-C. Tsui, J.-M. Lalouel and R.
White: Twenty-five loci form a continuous linkage map of markers for human chromosome 7.
Genomics, 5:866-873, 1989
58. P.G. Ashton-Richkardt, M.G. Dunlop, Y. Nakamura, R.G. Morris, C.A. Purdie, C.M. Steel, H.J.
Evans, C.C. Bird and A.H. Wyllie: High frequency of APC loss in sporadic colorectal carcinoma
due to breaks clustered in 5q21-22. Oncogene, 4:1169-1174, 1989
59. Y. Nakamura, M. Leppert, P. O'Connell, M. Lathrop, J.-M. Lalouel and R. White: A genetic linkage
map of markers for human chromosome 20. Genomics, 5:945-947, 1989
60. D. Ledbetter, S. Ledbetter, P. vanTuinen, K. Summers, T. Robinson, Y. Nakamura, R. Wolff, R.
White, D. Barker, M. Wallace, F. Collins and W. Dobyns: Molecular dissection of a contiguous
gene syndrome: Frequent submicroscopic deletions, evolutionarily conserved sequences, and a
hypomethylated "island" in the Miller-Dieker chromosome region. Proc. Natl. Acad. Sci. USA,
86:5136-5140, 1989
61. H. Sobol, S. Narod, Y. Nakamura, A. Bonue, C. Calmettes, D. Chadenas, G.Charpentier, J.
Chatal, N. Delepine, M. Delisle, J. Dupond, P. Gardet, H. Godefroy, P. Guillausseau, C. Sholer, C.
Houdent, J. Lalau, G. Mace, C. Parmentier, F. Soubrier, J. Tourniaire and G. Lenoir: Screening
for multiple endocrine neoplasia type 2a with DNA-polymorphism analysis. New Eng. J. Med.,
321:996-1001, 1989
62. E. Friedman, K. Sakaguchi, A. Bale, A. Falchetti, E. Streeten, M. Zimering, L. Wenstein, W.
McBride, Y. Nakamura, M. Brandi, J. Norton and G. Aurbach: Clonality of parathyroid tumors in
familial multiple endocrine neoplasia type1. New Eng. J. Med., 321:213-218, 1989
63. R. Gatti, Y. Nakamura, M. Nussmeier, E. Susi, W. Shan and W. Grody: Informativeness of VNTR
genetic markers for detecting chimerism after bone marrow transplantation. Disease Markers,
7:105-112, 1989
64. T. Sato, H. Uemura, Y. Izumoto, J. Nakao, Y. Nakamura, and K. Matsubara: The conformation of
mature human alpha-amylase conditions its secretion from yeast. Gene, 83:355-365, 1989
65. G.I. Bell, J. Murray, Y. Nakamura, T. Kayano, R. Eddy, Y.-S. Fan, M. Byers and T. Shows:
Polymorphic human insulin-responsive glucose-transporter gene on chromosome 17p13.
Diabetes, 38:1072-1075, 1989
66. J. Toguchida, K. Ishizaki, Y. Nakamura, M. Sasaki, M. Ikenaga, M. Kato, M. Sugimoto, Y. Kotoura,
and T. Yamamoto: Assignment of common allele loss in osteosarcoma to the subregion 17p13.
67. B. Nelkin, Y. Nakamura, R. White, A. Bustros, J. Herman, S. Wells and S. Baylin: Low incidence
of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma. Cancer
Research, 49:4114-4119, 1989
68. R. Korneluk, A. MacKenzie, Y. Nakamura, I. Dube, P. Jacob and A. Hunter: A reordering of
human chromosome 19 long-arm DNA markers flanking the myotonic dystrophy locus. Genomics,
5:596-604, 1989
69. B. Ponder, B. Smith, E. Marcus, Y. Nakamura, R. Landsvater. C. Buys and c. Mathew: Genetic
Events in tumorigenesis in multiple endocrine neoplasia type 2. Cancer Cells, 7:219-221, 1989
70. M. El-Azouzi, R. Chung, G. Farmer, R. Martuza, P. Black, G. Rouleau, C. Hettlich, E.
Hedley-Whyte, N. Zervas, K. Panagopoulos, Y. Nakamura, J. Gusella and B. Seizinger: Loss of
distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human
astrocytomas. Proc. Natl. Acad. Sci. USA, 86:7186-7190, 1989
71. S.J. Odelberg, R. Plaetke, J.R. Eldridge, L. Ballard, P. O'Connell, Y. Nakamura, M. Leppert, J.-M.
Lalouel and R. White: Characterization of eight VNTR loci by agarose gel electrophoresis:
Implications for parentage testing and forensic individualization. Genomics, 5:915-924, 1989
72. S.A. Narod, H. Sobol, Y. Nakamura, C. Calmettes, J.-L. Baulieu, J.-C. Bigorgne, G. Chabrier, J.
Couette, J.-L. Gennes, J. Duprey, P. Gardet, P.-J. Guillausseau, D. Guilloteau, C. Houdent, J.
Lefebvre, E. Modigliani, C. Parmentier, M. Pugeat, C. Siame, J. Tourniaire, J.-C. Vandroux, J.-M.
Vinot, G.M. Lenoir: Linkage analysis of hereditary thyroid carcinoma with and without
pheochromocytoma. Human Genetics, 83:353-358, 1989
73. D. Fults, R. Tippets, G.A. Thomas, Y. Nakamura and R. White: Loss of heterozygosity for loci on
chromosome 17p in human malignant astrocytoma. Cancer Research, 49:6572-6577, 1989
74. D. Fults, P.F. Maness, Y. Nakamura and R. White: The N-ras oncogene is activated in a human
medulloblastoma cell line. Brain Research, 503:281-287, 1989
75. S. Kern, E. Fearon, K.W.F. Tersmette, J.P. Enterline, M. Leppert, Y. Nakamura, R. White, B.
Vogelstein and S. Hamilton: Allelic loss in colorectal carcinoma. JAMA, 261:3099-3103, 1989
76. R. White, J.-M. Lalouel, M. Leppert, M. Lathrop, Y. Nakamura and P. O'Connell: Linkage maps of
human chromosomes. Genome, 31:1066-1072, 1989
77. HR. Chang, M. Scik., K. Ishizaki, M. S. Sasaki, J. Toguchida, M. Kato, M. Pharm, Y. Nakamura, S.
Kawamura, T. Moriguchi, M. Ikenaga: Somatic mosaicism for DNA repair capacity in fibroblasts
derived from a group a xeroderma pigmentosum patinent. The Journal of Investigative
Dematology, 93:460-465, 1989
78. H. Telenius, C.P.G. Mathew, Y. Nakamura, D.F. Easton, J. Clark, H.P.N. Neumann, W.H. Ziegler,
A. Schinzel and B.A.J. Ponder: Application of linked DNA markers to screening families with
multiple endocrine neoplasia type 2A. Eur. J. Sug. Oncology, 16:134-140, 1990
79. M.H. Hofker, S. Smith, Y. Nakamura, I. Teshima, R. White and D. Cox: Physical mapping of
probes within 14q32, a subtelomeric region showing a high recombination frequency. Genomics,
6:33-38, 1990
80. M. Smith, S. Malley, R. Cantor, M. Pandolfo, M. Gomes, R. Baumann, P. Flodman, K. Yoshiyama,
Y. Nakamura, C. Julier, K. Dumars, J. Haines, J. Trofatter, M.A. Spence, D. Weeks and M.
Conneally: Mapping of a gene determining tuberous sclerosis to human chromosome
11q14-11q23. Genomics, 6:105-114, 1990
81. C. Julier, Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, T. Mohandas, J.-M. Lalouel and R.
White: A primary map of 24 loci on human chromosome 16. Genomics, 6:419-427, 1990
82. R.L. White, J.-M. Lauloel, Y. Nakamura, H.D.-Keller, P Green, D.W. Bowden, C.G.P. Mathew,
D.F. Easton, E.B. Robson, N.E. Morton, J.F.Gusella, J.L. Haines, A.E. Retief, K.K. Kidd, J.C.
Murray, G.M. Lathrop and H.M. Cann: The CEPH consortium primary linkage map of human
83. M. Leppert, R. Burt, J. Hughes, W. Samowitz, Y. Nakamura, S. Woodward, E. Gardner, J. Lalouel
and R. White: Genetic analysis of an inherited predisposition to colon cancer in a family with a
variable number of adenomatous polyps. New Eng. J. Med., 322:904-908, 1990
84. P. Patel, B. Franco, C. Garcia, S. A. Slaugenhaupt, Y. Nakamura, D. Ledbetter, A. Chakravarti
and J. R. Lapski: Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a
large French-Acadian kindred: identification of new linked markers on chromosome 17. Am. J.
Human Genetics, 46:801-809, 1990
85. J.C. Murray, D.Y. Nishimura, K.H. Buetow, H.H. Ardinger, M.A. Spence, R.S. Sparkes, R.E. Falk,
P.M. Falk, R.J. Gardner, E.M. Harkness, L.P. Glinski, R.M. Pauli, Y. Nakamura, P.P. Green and A.
Schinzel: Linkage of an autosomal dominant clefting syndrome (Van der Woude) to loci on
chromosome 1q. Am. J. Human Genetics, 46:486-491, 1990
86. R. White, Y. Nakamura, P. O'Connell, M. Leppert and J-M. Lalouel: Mapping genetic defects by
linkage studies in families: A strategy for finding genes associated with cancer syndromes.
Genetic Mechanisms in Carcinogenesis and Tumor Progression, :153-161, 1990
87. G.G. Germino, N.J. Barton, J. Lamb, K.R. Higgs, P. Harris, G.H. Xiao, G. Scherer, Y. Nakamura
and S.T. Reeder: Identification of a locus which shows no genetic recombination with the
autosomal dominant polycystic kidney disease gene on chromosome 16. Am. J. Human Genetics,
46:925-933, 1990
88. J. Groden, Y. Nakamura and J. German: Bloom syndrome: Molecular evidence that homologous
recombination occurs in proliferating somatic cells. Proc. Natl. Acad. Sci. USA, 87:4315-4319,
1990
89. K. Ishizaki, M. Oshimura, M.S. Sasaki, Y. Nakamura and M. Ikenaga: Human chromosome 9 can
complement UV sensitivity of xeroderma pigmentosum group a cells. Mutation Research,
235:209-215, 1990
90. C.G.P. Mathew, W. Wakiling, E. Jones, D. Easton, R. Fisher, C. Strong, B. Smith, K. Chin, P.
Little, Y. Nakamura, T.B. Shows, C. Jones, P.J. Goodfellow, S. Povey and B.A.J. Ponder:
Regional localization of polymorphic markers on chromosome 10 by physical and genetic
mapping. Annals Human Genetics, 54:121-129, 1990
91. C. Julier, B. Gouyon, M. Jeorges, J.L. Guenet, Y. Nakamura, P. Avner and M. Lathrop:
Minisatellite linkage maps in the mouse by cross-hybridization with human probes containing
tandem repeats. Proc. Natl. Acad. Sci. USA, 87:4585-4589, 1990
92. G.M. Petersen, J. Brown, X. Bu, R.S. Sparkers and Y. Nakamura: Genetic linkage study of
juvenile polyposis: Preliminary analysis. Hereditary colorectal cancer, :423-430(432?), 1990
93. M. Leppert, Y. Nakamura, R. Burt, J.P. Hughes, W. Samowitz, S. Woodward, E. Gardner, J.-M.
Lalouel and R. White: Genetic mapping and allelic heterogeneity of the familial polyposis gene.
Hereditary colorectal cancer, :27-36, 1990
94. A.H. Wyllie, P. Ashton-Rickardt, M.G. Dunlop, Y. Nakamura, J. Piris, C. Purdie, C.M. Steel and
C.C. Bird: Status of the APC gene in familial and sporadic colorectal tumours as determined by
closely flanking markers. Hereditary colorectal cancer, :453-456, 1990
95. Y. Nakamura, J. Wasmuth and R. White: Searching the gene responsible to familial polyposis
coli(FAP). Hereditary colorectal cancer, :469-472, 1990
96. Y. Nakamura, R.L. White: Summary of chapter 7: Cytomolecular aspects of colorectal cancer.
Hereditary colorectal cancer, :475-476, 1990
97. R. White, M. Leppert, Y. Nakamura, P. O'Connell, M. Lathrop and J.-M. Lalouel: Mapping genes
that cause disease. The cellular and molecular biology of human carcinogenesis, :61-77, 1990
98. Y. Nakamura:, Clinical application of restriction fragment length polymorphisms (RFLPs).
Automation and new technology in the clinical laboratory, :131-137, 1990
99. C. Julier, Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, M. Litt, T. Mohandas, J.-M. Lalouel
and R. White: A detailed genetic map of the long arm of chromosome 11. Genomics, 7:335-345,
1990
100. H. Shibuya, M. Yoneyama, Y. Nakamura, H. Harada, M. Hatakeyama, S. Minamoto, T. Kono, T.
Doi, R. White, and T. Taniguchi: The human interleukin-2 receptor β-chain gene: genomic
organization, promoter analysis and chromosomal assignment. Nucleic Acids Research,
18:3697-3703, 1990
101. K.H. Buetow, D. Nishimura, P. Green, Y. Nakamura, O. Jiang and J.C. Murray: A detailed
multipoint gene map of chromosome 1q. Genomics, 8:13-21, 1990
102. K. Kasai, Y. Nakamura and R. White: Amplification of a VNTR locus (pMCT118) by the
polymerase chain reaction (PCR) and its application to forensic science. J. Forensic Sci.,
35:1196-1200, 1990
103. D.M. Eccles, G. Cranston, C.M. Steel, Y. Nakamura, and R.C.F. Leonard: Allele losses on
chromosome 17 in human epithelial ovarian carcinoma. Oncogene, 5:1599-1601, 1990
104. T. Sato, A. Tanigami, K. Yamakawa, F. Akiyama, F. Kasumi, G. Sakamoto and Y. Nakamura:
Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast
cancer. Cancer Research, 50:7184-7189, 1990
105. M. Miyaki, M.Seki, M. Okamoto, A. Yamanaka, Y. Maeda, K. Tanaka, R. Kikuchi, T. Iwama, T.
Ikeuchi, A. Tonomura, Y. Nakamura, R. White, Y. Miki, J. Utsunomiya and M. Koike: Genetic
changes and histopathological types in colorectal tumors from patients with familial adenomatous
polyposis. Cancer Research, 50:7166-7173, 1990
106. J.R. Batanian, S. Ledbetter, R. Wolff, Y. Nakamura, R. White, W. Dobyns and D. Ledbetter: Rapid
diagnosis of Miller-Dieker syndrome and isolated lissencephaly sequence by the polymerase
chain reaction. Human Genetics, 85:555-559, 1990
107. M.G. Dunlop, A.W. Wyllie, Y. Nakamura, C.M. Steel, H.J. Evans, R. White and C.C. Bird: Genetic
linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis
on chromosome 5. Am. J. Human Genetics, 47:982-987, 1990
108. M. Okamoto, C. Sato, Y. Kohno, T. Mori, T. Iwama, A. Tonomura, Y. Miki, J. Utsunomiya, Y.
Nakamura, R. White and M. Miyaki: Molecular nature of chromosome 5q loss in colorectal tumors
and desmoids from patients with familial adenomatous polyposis. Human Genetics, 85:595-599,
1990
109. P. Patel, S. O'Rahilly, V. Buckle, Y. Nakamura, R.C. Turner and J.S. Wainscoat: Chromosome 11
allele loss in sporadic insulinoma. J. Clin. Pathol., 43:377-378, 1990
110. C. Coles, A.M. Thompson, P.A. Elder, B.B. Cohen, I.M. Mackenzie, G. Cranston, U. Chetty, J.
Mackay, M. Macdonald, Y. Nakamura, B. Hoyheim and C.M. Steel: Evidence implicating at least
two genes on chromosome 17p in breast carcinogenesis. Lancet, 336:761-763, 1990
111. T. Tokino, E. Takahashi, M. Mori, A. Tanigami, T. Glaser, J.W. Park, C. Jones, T. Hori and Y.
Nakamura: Isolation and mapping of 62 new RFLP markers on human chromosome 11. Am. J.
112. C.G.P. Mathew, D.F. Easton, Y. Nakamura and B.A.J. Ponder: Presymptomatic screening for
multiple endocrine neoplasia type 2A with linked DNA markers. Lancet, 337:7-11, 1991
113. M. Fujimori, T. Tokino, O. Hino, T. Kitagawa, T. Imamura, E. Okamoto, M. Mitsunobu, T. Ishikawa,
H. Nakagama, H. Harada, M. Yagura, K. Matsubara and Y. Nakamura: Allelotype study of primary
hepatocellular carcinoma. Cancer Research, 51:89-93, 1991
114. R. Morita, J. Ishikawa, M. Tsutsumi, K. Hikiji, Y. Tsukada, S. Kamidono, S. Maeda and Y.
Nakamura: Allelotype of renal cell carcinoma. Cancer Research, 51:820-823, 1991
115. K. Yamakawa, E. Takahashi, H. Saito, T. Sato, M. Oshimura, T. Hori and Y. Nakamura: Isolation
and mapping of 75 new DNA markers on human chromosome 3. Genomics, 9:536-543, 1991
116. K.W. Kinzler, M.C. Nilbert, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, S.R.
Hamilton, P. Hedge, A. Merkham, M. Carlson, G. Joslyn, J. Groden, R. White, Y. Miki, I. Nishisho
and Y. Nakamura: Identification of a gene located at chromosome 5q21 that is mutated in
colorectal cancers. Science, 251:1366-1370, 1991
117. T. Sano, T. Tsujino, K. Yoshida, H. Nakayama, K. Haruma, H. Ito, Y. Nakamura, G. Kajiyama and
E. Tahara: Frequent loss of heterozygosity on chromosome 1q, 5q and 17p in human gastric
carcinomas. Cancer Research, 51:2926-2931, 1991
118. G. Petersen, J. Slack and Y. Nakamura: Screening guidelines and premorbid diagnosis of familial
adenomatous polyposis using linkage. Gastroenterology, 100:1658-1664, 1991
119. K.H. Buetow, R. Shiang, P. Yang, Y. Nakamura, G.M. Lathrop, R. White, J.J. Wasmuth, S. Wood,
L.D. Berdahl, N.J. Leysens, T.M. Ritty, M.E. Wise, and J.C. Murray: A detailed multipoint map of
human chromosome 4 provides evidence for linkage heterogeneity and position-specific
recombination rates. Am. J. Human Genetics, 48:911-925, 1991
120. P.G. Ashton-Richkardt, A.H. Wyllie, C.C. Bird, M.G.Dunlop, C.M. Steel, R.G. Morris, J. Piris, P.
Romanowski, R.Wood, R. White, and Y. Nakamura: MCC, a candidate familial polyposis gene in
5q.21, shows frequent allele loss in colorectal and lung cancer. Oncogene, 6:1881-1886, 1991
121. Y. Miki, I. Nishisho, Y. Miyoshi, A. Horii, H. Ando, T. Nakajima, J. Utsunomiya and Y. Nakamura:
Frequent loss of heterozygosity at the MCC locus on chromosome 5q21-22 in sporadic colorectal
carcinomas. Japanese Journal of Cancer Research, 82:1003-1007, 1991
122. K. Yamakawa, R. Morita, E. Takahashi, T. Hori, J. Ishikawa, and Y. Nakamura: A detailed
deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer
Research, 51:4707-4711, 1991
123. T. Sato, H. Saito, R. Morita, S. Koi, Je H. Lee, and Y. Nakamura: Allelotype of human ovarian
124. K. Yamakawa, R. Morita, E. Takahashi, M. Lathrop, and Y. Nakamura: A genetic linkage map of
41 RFLP markers for human chromosome 3. Genomics, 11:565-572, 1991
125. K.W. Kinzler, M.C. Nilbert, L. Su, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C.
Preisinger, P. Hedge, D. McKechnie, R. Finniear, A. Markham, J. Groffen, M.S. Boguski, S.F.
Alschul, A. Horii, H. Ando, Y. Miyoshi, Y. Miki, I. Nishisho, Y. Nakamura: Identification of FAP
locus genes from chromosome 5q21. Science, 253:661-665, 1991
126. I. Nishisho, Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S.
Baba, P. Hedge, A. Markham, A.J. Krush, G. Petersen, S.R. Hamilton, M.C. Nilbert, D.B. Levy,
T.M. Bryan, A.C. Preisinger, K.J. Smith, L. Su, K.W. Kinzler, and B. Vogelstein: Mutations of
chromosome 5q21 genes in FAP and colorectal cancer patients. Science, 253:665-669, 1991
127. R. Morita, S. Saito, J. Ishikawa, O. Ogawa, O. Yoshida, K. Yamakawa, Y. Nakamura: Common
regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma. Cancer Research,
51:5817-5820, 1991
128. S. Itoh, H. Harada, Y. Nakamura, R. White, T. Taniguchi: Assignment of the human interferon
regulatory factor-1 (IRF1) gene to chromosome 5q23-q31. Genomics, 10:1097-1099, 1991
129. T. Sato, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura: Accumulation of genetic alterations
and progression of primary breast cancer. Cancer Research, 51:5794-5799, 1991
130. M. Janson, C. Larsson, B. Werelius, C Jones, T. Glaser, Y. Nakamura, C. Peter Jones, M.
Nordenskjold: Detailed physical map of human chromosomal region 11q12-13 shows high
meiotic recombination rate around the MEN1 locus. Proc. Natl. Acad. Sci. USA, 88:10609-10613,
1991
131. BR Seizinger, H.P. Klinger, C. Junien, Y. Nakamura, M. Le Beau, W. Cavenee, B. Emanuel, B.
Ponder, S. Naylor, F. Mitelman, D. Louis, A. Menon, I. Newsham, J. Decker, M. Kaelbling, I.
Henry, Av. Deimling: Report of the committee on chromosome and gene loss in human neoplasia
Cytogenetic and Genome Research, 58:1080-1096, 1991
132. Y. Miki, I. Nishisho, Y. Miyoshi, J. Utsunomiya, Y. Nakamura: Interstitial loss of the same region of
5q in multiple adenomas and a carcinoma derived from adenomatous polyposis coli (APC) patient.
Genes Chromosomes and Cancer, 4:81-83, 1992
133. M. Thangavelu, W. Neuman, R. Espinosa, Y. Nakamura, C.A. Westbrook, M. M. Le Beau: A
physical and genetic linkage map of the distal long arm of chromosome 5. Cytogenetics Cell
Genetics, 59:27-30, 1992
134. S. Saito, K. Okui, T. Tokino, M. Oshimura, Y. Nakamura: Isolation and mapping of 68 RFLP
markers on human chromosome 6. Am. J. Human Genetics, 50:65-70, 1992
135. A. Tanigami, T. Tokino, S. Takiguchi, M. Mori, T. Glaser, J.W. Park, C. Jones, Y. Nakamura:
Mapping of 262 DNA markers into 24 intervals on human chromosome 11. Am. J. Human
Genetics, 50:56-64, 1992
136. T. Tokino, T. Imai, A. Tanigami, S. Takiguchi, Y. Nakamura: Physical mapping of a 950-kb region
surrounding a locus (D10S102) tightly linked to the MEN2A gene. Genomics, 12:394-400, 1992
137. T. Tokino, S. Takiguchi, A. Tanigami, T. Bragg, C. Jones, Y. Nakamura: 31 new RFLP systems
detected by 24 DNA markers on human chromosome 10. Genomics, 12:401-402, 1992
138. M. Fujimori, S. A. Wells Jr, Y. Nakamura: Fine-scale mapping of the gene responsible for multiple
endocrine neoplasia type 1 (MEN1). Am. J. Human Genetics, 50:399-403, 1992
139. K. Hibi, T. Takahashi, K. Yamakawa, R. Ueda, Y. Sekido, Y. Ariyoshi, M. Suyama, H. Takagi, Y.
Nakamura, T. Takahashi: Three distinct regions involved in 3p deletion in human lung cancer.
Oncogene, 7:445-449, 1992
140. Y. Miyoshi, I. Nishisho, Y. Miki, T. Mori, K. Kinzler, B. Vogelstein, Y. Nakamura: Insertion/deletion
polymorphism and other restriction fragment length polymorphisms in the MCC gene. Japanese
Journal of Cancer Research, 83:10-14, 1992
141. S. Yokoyama, K. Yamakawa, E. Tsuchiya, M. Murata, S. Sakiyama, Y. Nakamura: Deletion
mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of
the lung. Cancer Research, 52:873-877, 1992
142. Y. Miki, I. Nishisho, A. Horii, Y. Miyoshi, J. Utsunomiya, K. Kinzler, B. Vogelstein. Y. Nakamura:
Disruption of the APC gene by retrotransposal insertion of L1 sequence in a colon cancer. Cancer
Research, 52:643-645, 1992
143. M. Mori, T. Tokino, A. Yanagisawa, M. Kanamori, Y. Kato, Y. Nakamura: Association between
11q13 amplification and prognosis of patients with oesophageal carcinomas. Europian Journal of
Cancer, 28:755-757, 1992
144. A. Tanigami, T. Tokino, K. Takita, S. Takiguchi, Y. Nakamura: A 14-mb physical map of the region
at chromosome 11q13 harboring the MEN1 locus and the tumor amplicon region (TAR).
Genomics, 13:16-20, 1992
145. T. Hori, E. Takahashi, A. Tanigami, T. Tokino, Y. Nakamura: A high-resolution cytogenetic map of
168 cosmid DNA markers for human chromosome 11. Genomics, 13:129-133, 1992
146. H. Takayama, T. Suzuki, H. Mugishima, T. Fujisawa, M. Ookuni, M. Schwab, M. Gehring, Y.
Nakamura, T. Sugimura, M. Terada and J. Yokota: Deletion mapping of chromosome 14q and 1p
in human neuroblastoma. Oncogene, 7:1185-1189, 1992
147. Y. Miyoshi, H. Ando, H. Nagase, I. Nishisho, A. Horii, Y. Miki, T. Mori, J. Utsunomiya, S. Baba, G.
Petersen, S.R. Hamilton, K.W. Kinzler, B. Vogelstein, Y. Nakamura: Germ-line mutations of the
APC gene in 53 familial adenomatous polyposis patients. Proc. Natl. Acad. Sci. USA,
89:4452-4456, 1992
148. M.H. Jones, and Y. Nakamura: Detection of loss of heterozygosity at the human tp53 locus using
a dinucleotide repeat polymorphism. Genes Chromosomes and Cancer, 5:89-90, 1992
149. A. Tanigami, T. Tokino, K. Takita, M. Ueda, F. Kasumi, Y. Nakamura: Detailed analysis of an
amplified region at chromosome 11q13 in malignant tumors. Genomics, 13:21-24, 1992
150. T. Yamaguchi, J. Toguchida, Y. Nakamura, T. Yamamuro, Y. Kotoura, N. Takada, N. Kawaguchi,
Y. Kaneko, M. S. Sasaki, K. Ishizaki: Allelotype analysis in osteosarcomas ; Frequent allele loss
on 3q, 13q, 17p and 18q. Cancer Research, 52:2419-2423, 1992
151. T. Sato, H. Saito, J. Swensen, A. Olifant, C. Wood, D. Danner, T. Sakamoto, K. Takita, F. Kasumi,
Y. Miki, M. Skolnick, Y. Nakamura: The human prohibitin gene, located on chromosome 17q21 is
mutated in sporadic breast cancer. Cancer Research, 52:1643-1646, 1992
152. M.H. Jones, and Y. Nakamura: Deletion mapping of chromosome 3p in female genital tract
malignancies using microsatellite polymorphisms. Oncogene, 7:1631-1634, 1992
153. E. Tsuchiya, Y. Nakamura, S. Weng, K. Nakagawa, S. Tsuchiya, H. Sugano and T. Kitagawa:
Allelotype of non-small cell lung carcinoma-comparison of loss of heterozygosity between
squamous cell carcinoma and adenocarcinoma. Cancer Research, 52:2478-2481, 1992
154. M.H. Jones, K. Yamakawa and Y. Nakamura: Isolation and characterization of 19
dinucleotide-repeat polymorphisms on chromosome 3p. Human Molecular Genetics, 1:131-134,
1992
155. J. Utsunomiya, K. Tamura, R. Yoshikawa, Y. Miki, M. Miyaki, and Y. Nakamura: New insights into
familial adenomatous polyposis. Recent Progress in Colorectal Cancer: Biology and Management
of High Risk Groups., :203-210, 1992
156. E. Takahashi, K. Yamakawa, Y. Nakamura and T. Hori: A high resolution cytogenetic map of
human chromosome 3: localization of 291 new cosmid markers by direct r-banding fluorescence
in situ hybridization. Genomics, 13:1047-1055, 1992
157. D. Cherif, H. Der-Sarkissian, J. Derre, T. Tokino, Y. Nakamura and R. Berger: The 11q23
breakpoint in acute leukemia with t(11;19)(q23;p13) is distal to those of t(4;11),t(6;11) and t(9;11).
158. K. Takita, T. Sato, M. Miyagi, M. Watatani, F. Akiyama, G. Sakamoto, F. Kasumi, R. Abe, and Y.
Nakamura: Correlation of loss of alleles on the short arms of chromosome 11 and 17 with
metastasis of primary breast cancer to lymphnodes. Cancer Research, 52:3914-3917, 1992
159. M. Jones, and Y. Nakamura: Somatic mutations at CA-repeat loci. Human Mutation, 1:224-228,
1992
160. H. Nagase, Y. Miyoshi, A. Horii, T. Aoki, M. Ogawa, J. Utsunomiya, S. Baba, T. Sasazuki and Y.
Nakamura: Correlation between the location of germ-line mutations in the APC gene and the
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162.
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164.
165.
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number of colorectal polyps in familial adenomatous polyposis (FAP) patients. Cancer Research,
52:4055-4057, 1992
A. Horii, S. Nakatsuru, Y. Miyoshi, S. Ichii, H. Nagase, Y. Kato, A. Yanagisawa and Y. Nakamura:
The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric
K. Takita, A. Tanigami, T. Tokino, C. Jones and Y. Nakamura: Identification of 57 conventional
RFLP and 6 VNTR systems with 32 DNA clones on chromosome 11p15. Genomics,
13:1296-1299, 1992
M. Peter, J. Michon, P. Vielh, S. Neuenschwander, Y. Nakamura, E. Sonsino, J.-M. Zucker, G.
Vergnaud, G. Thomas and O. Delattre: PCR assay for chromosome 1p deletion in small
neuroblastoma samples. International Journal of Cancer, 52:544-548, 1992
M. Emi, K. Koyama, K. Okui, E. Takahashi, M. Oshimura and Y. Nakamura: Isolation and
mapping of 88 new RFLP markers on human chromosome 8. Genomics, 13:1261-1266, 1992
Y. Miyoshi, H. Nagase, H. Ando, A. Horii, S. Ichii, S. Nakatsuru, T. Aoki, Y. Miki, T. Mori and Y.
Nakamura: Somatic mutation of the APC gene in colorectal tumors: mutation cluster region in the
APC gene. Human Molecular Genetics, 1:229-233, 1992
K. Yamakawa, E. Takahashi, M. Murata, K. Okui, S. Yokoyama and Y. Nakamura: Detailed
mapping around the breakpoint of (3;8) translocation in familial renal cell carcinoma and FRA3B.
Genomics, 14:412-416, 1992
K. Tsukamoto, T. Tohma, T. Ohta, K. Yamakawa, Y. Fukushima, Y. Nakamura and N. Niikawa:
Cloning and characterization of the inversion breakpoint at chromosome 2q35 in a patient with
Waardenburg syndrome type I. Human Molecular Genetics, 1:315-317, 1992
M. Emi, Y. Fujiwara, T. Nakajima, E. Tsuchiya, H. Tsuda, S. Hirohashi, M. Miyaki and Y.
Nakamura: Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular
carcinoma, colorectal cancer, and lung cancer. Cancer Research, 52:5368-5372, 1992
C. Larsson, J. Shepherd, Y. Nakamura, C. Blomberg, G. Weber, B. Werelius, N. Hayward, B. Teh,
T. Tokino, B. Seizinger, B. Skogseid, K. Oberg, and M. Nordenskjold: Predictive testing for
multiple endocrine neoplasia type 1 using DNA polymorphisms. Journal of Clinical Investigation,
89:1344-1349, 1992
W. Cookson, R.P. Young, A.J. Sandford, M.F. Moffatt, T. Shirakawa, P.A. Sharp, J.A. Faux, C.
Julier, R.A. Wells, P.N. Le Souef, Y. Nakamura, G.M. Lathrop and J.M. Hopkin: Maternal
inheritance of atopic IgE responsiveness on chromosome 11q. Lancet, 340:381-384, 1992
S. Ichii, A. Horii, S. Nakatsuru, J. Furuyama, J. Utsunomiya and Y. Nakamura: Inactivation of both
APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis
(FAP). Human Molecular Genetics, 1:387-390, 1992
Y. Nakamura, I. Nishisho, K. Kinzler, B. Vogelstein, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, and H.
Nagase: Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and
sporadic colorectal tumors. Multistage carcinogenesis, :285-292, 1992
S. Saito, H. Saito, S. Koi, S. Sagae, R. Kudo, J. Saito, K. Noda and Y. Nakamura: Fine-scale
deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancers. Cancer
Research, 52:5815-5817, 1992
NIH, CEPH Collaborative Mapping Group: A comprehensive genetic linkage map of the human
genome. Science, 258:67-86, 1992
A. Horii, S. Nakatsuru, Y. Miyoshi, S. Ichii, H. Nagase, H. Ando, A. Yanagisawa, E. Tsuchiya, Y.
Kato, and Y. Nakamura: Frequent Somatic mutation of the APC gene in human pancreatic cancer.
M. Shohat, X. Bu, T. Shohat, N. Fischel-Ghodsian, N. Magal, Y. Nakamura, A.D. Schwabe, M.
Schlezinger, Y. Danon, J.I. Rotter: The gene for familial mediterranean fever in both Armenians
and non-ashkenazi Jews is linked to the alpha-globin complex on 16p: evidence for locus
homogeneity. Am. J. Human Genetics, 51:1349-1354, 1992
M. Miyagi, J. Inazawa, K. Takita, and Y. Nakamura: Cloning and characterization of the
breakpoint of an interstitial deletion at chromosome 11p15 in a sporadic breast cancer. Human
Molecular Genetics, 1:705-708, 1992
S. Nakatsuru, A. Yanagisawa, S. Ichii, E. Tahara, Y. Kato, Y. Nakamura, and A. Horii: Somatic
mutation of the APC gene in gastric cancer: Frequent mutations in very well differentiated
adenocarcinoma and signet-ring cell carcinoma. Human Molecular Genetics, 1:559-563, 1992
S. Nagafuchi, Y. Nakahori, Y. Nakamura, S.B. England, T. Tamura, H. Numabe, and Y.
Nakagome: Localization of 24 cosmid clones on the human Y chromosome. Japanese Journal of
H. Nagase, Y. Miyoshi, A. Horii, T. Aoki, G.M. Petersen, B. Vogelstein, E. Maher, M. Ogawa, J.
Utsunomiya, S. Baba, and Y. Nakamura: Screening for Germ-Line Mutations in Familial
Adenomatous Polyposis (FAP) Patients: 61 new patients and a summary of 150 Unrelated
Patients. Human Mutation, 1:467-473, 1992
Y. Nakamura, I. Nishisho, K.W. Kinzler, B. Vogelstein, Y. Miyoshi, Y. Miki, H. Ando, and A. Horii:
Mutations of the APC (Adenomatous Polyposis Coli) gene in FAP (Familial Polyposis Coli)
patients and in sporadic colorectal tumors. Tohoku J. Exp. med., 168:141-147, 1992
182. S. Olschwang, R. Fabre, P. Laurentpuig, A. Vassal, B. Hamelin, Y. Nakamura, and G. Thomas:
Detection by dgge of a new polymorphism closely linked to the adenomatous polyposis-coli
region. Human Genetics, 88:658-660, 1992
183. S. Saito and Y. Nakamura: A genetic linkage map with 16 RFLP loci on the distal long arm of
human chromosome 6. Genomics, 15:103-106, 1993
184. K. Yamakawa, Ta. Takahashi, Y. Horio, Y. Murata, E. Takahashi, K. Hibi, S. Yokoyama, R. Ueda,
To. Takahashi and Y. Nakamura: Frequent homozygous deletion in lung cancer cell lines
detected by a DNA marker located at 3p21.3-p22. Oncogene, 8:327-330, 1993
185. E. Arai, T. Tokino, T. Imai, J. Inazawa, Y. Ikeuchi, A. Tonomura, and Y. Nakamura: Mapping the
breakpoint of a constitutional translocation on chromosome 22 in a patient with NF2. Genes
Chromosomes and Cancer, 6:235-238, 1993
186. W. Neuman, C. Westbrook, M. Dixon, R. Espinosa, Y. Patel, Y. Nakamura, B. Weiffenbach, and
M. LeBeau: Physical localization of 70 polymorphic markers to human chromosome 5 by
fluorescence in situ hybridization. Cytogenetics Cell Genetics, 62:207-210, 1993
187. Y. Fujiwara, M. Monden, T. Mori, Y. Nakamura, and Mitsuru Emi: Frequent multiplication of the
long arm of chromosome 8 in hepatocellular carcinoma. Cancer Research, 53:857-860, 1993
188. H. Ando, Y. Miyoshi, H. Nagase, S. Baba, and Y. Nakamura: Detection of twelve germ-line
mutations in the adenomatous polyposis coli (APC) gene by PCR. Gastroenterology,
104:989-993, 1993
189. G.M. Petersen, C. Francomano, K. Kinzler, Y. Nakamura: Presymptomatic direct detection of
adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis. Human
Genetics, 91:307-311, 1993
190. M. Emi, Y. Fujiwara, and Y. Nakamura: A primary genetic linkage map of 14 polymorphic loci for
the short arm of human chromosome 8. Genomics, 15:530-534, 1993
191. A. Horii, S. Nakatsuru, S. Ichii, H. Nagase, and Y. Nakamura: Multiple forms of the APC gene
transcripts and their tissue-specific expression. Human Molecular Genetics, 2:283-287, 1993
192. K. Koyama, M. Emi, and Y. Nakamura: The Cell Adhesion Regulator (CAR) gene: TaqI and
insertion/deletion polymorphisms, and regional assignment to periteromeric region of 16q by
linkage analysis. Genomics, 16:264-265, 1993
193. S. Takeda, S. Ichii and Y. Nakamura: Detection of K-ras mutation in sputum by
mutant-allele-specific amplification (MASA). Human Mutation, 2:112-117, 1993
194. H. Ohata, M. Emi, Y. Fujiwara, K. Higashino, K. Nakagawa, R. Futagami, E. Tsuchiya, and Y.
Nakamura: Deletion mapping of the short arm of chromosome 8 in non-small cell lung carcinoma.
195. Y. Nakamura:, The role of the adenomatous polyposis coli (APC) gene in human cancers
(review article). Advance in Cancer Genetics, 62:65-87, 1993
196. S. Takiguchi, S. Saito and Y. Nakamura: Characterization of four VNTR loci on human
chromosome 6. Mammalian Genome, 4:21-24, 1993
197. Y. Fujiwara, M. Emi, H. Ohata, Y. Kato, T. Nakajima, T. Mori, and Y. Nakamura: Evidence for a
presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma. Cancer
Research, 53:1172-1174, 1993
198. J. Melki, P. Burlet, O. Clermont, F. Pascal, B. Paul, S. Abdelhak, R. Sherrington, H. Gurling, Y.
Nakamura, J. Weissenbach, M. Lathrop and A. Munnich: Refined linkage map of chromosome 5
in the region of spinal muscular atrophy gene. Genomics, 15:521-524, 1993
199. J. Inazawa, H. Saito, T. Ariyama, T. Abe, and Y. Nakamura: High-resolution cytogenetic mapping
of 342 new cosmid markers including 43 RFLP markers on human chromosome 17 by
fluorescence in situ hybridization. Genomics, 17:153-162, 1993
200. Y. Horio, Ta. Takahashi, T. Kuroishi, K. Hibi, M. Suyama, T. Niimi, K. Shimokata, K. Yamakawa,
Y. Nakamura, R. Ueda, and To. Takahashi: Prognostic significance of p53 mutation and 3p
deletion in primary resected non-small cell lung cancer. Cancer Research, 53:1-4, 1993
201. A.J. Sandford, T. Shirakawa, M.F. Moffatt, S.E. Daniels, C. Ra, J.A. Faux, R.P. Young, Y.
Nakamura, G.M. Lathrop, W. Cookson and J.M. Hopkin: Localization of atopy and the βsubunit of
high-affinity IgE receptor (FcERI) on chromosome 11q. Lancet, 341:332-334, 1993
202. M. Emi, Y. Fujiwara, H. Ohata, H. Tsuda, S. Hirohashi, M. Koike, M. Miyaki, M. Monden, and Y.
Nakamura: Deletion of chromosome 8p21.3-p22 is associated with progression of hepatocellular
carcinoma. Genes Chromosomes and Cancer, 7:152-157, 1993
203. P.A. Crossey, E.R. Maher, M.H. Jones, F.M. Richards, F. Latif, M.E. Pipps, M. Lush, K. Foster, K.
Tory, J.S. Green, B. Oostra, J.R.W. Yates, W.M. Linehan, N.A. Affara, M. Lerman, B. Zbar, Y.
Nakamura, and M.A. Ferguson-Smith: Genetic linkage between Von Hippel-Lindau disease and
three microsatellite polymorphisms refines the localization of the VHL locus. Human Molecular
Genetics, 2:279-282, 1993
204. S. Takiguchi, T. Tokino, T. Imai, A. Tanigami, K. Koyama, and Y. Nakamura: Identification and
characterization of a cDNA, which is highly homologous to the ribonucleoprotein gene, from a
locus (D10S102) closely linked to MEN2 (multiple endocrine neoplasia type 2). Cytogenetics Cell
Genetics, 64:128-130, 1993
205. T. Mori, H. Nagase, T. Aoki, H. Arakawa, T. Nishihira, S. Mori, and Y. Nakamura: The APC
206.
207.
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(adenomatous polyposis coli) gene: a novel mutation in an FAP patient and a DdeI polymorphism
in the 5' non-coding region. Human Mutation, 2:240-243, 1993
S. Mole, M. Jackson, T. Tokino, Y. Nakamura, and B. Ponder: Assignment of fifty-four cosmid
clones to five regions of chromosome 10. Genomics, 15:457-458, 1993
S. Ichii, H. Nagase, T. Mori, S. Baba, and Y. Nakamura: A novel mutation of the APC
(adenomatous polyposis coli) gene in a familial adenomatous polyposis (FAP) patient and
presymptomatic diagnosis using PCR. Human Molecular Genetics, 2:597, 1993
T. Miwa, K. Sudo, Y. Nakamura, and T. Imai: Fifty sequenced-tagged sites on human
T. Sato, T. Sakamoto, K. Takita, H. Saito, K. Okui, and Y. Nakamura: The human prohibitin (PHB)
gene family and its somatic mutation in human tumors. Genomics, 17:762-764, 1993
S. Ichii, S. Takeda, A. Horii, S. Nakatsuru, Y. Miyoshi, M. Emi, Y. Fujiwara, K. Koyama, J.
Furuyama, J. Utsunomiya, and Y. Nakamura: Detailed analysis of genetic alterations in colorectal
tumors from patients with and without familial adenomatous polyposis (FAP). Oncogene,
8:2399-2405, 1993
M. Koi, L.A. Johnson, L.M. Kalikin, P.F.R. Little, Y. Nakamura, and A. Feinberg: Tumor cell
growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11.
Science, 260:361-364, 1993
E. Takahashi, S. Hitomi, K. Koyama, and Y. Nakamura: A high-resolution cytogenetic map of
human chromosome 5: localization of 206 new cosmid markers by direct R-banding fluorescence
in situ hybridization. Genomics, 17:234-236, 1993
H. Saito, J. Inazawa, S. Saito, F. Kasumi, S. Koi, S. Sagae, R. Kudo, J. Saito, K. Noda, and Y.
Nakamura: Detailed Deletion Mapping of Chromosome 17q in Ovarian and Breast Cancers: 2-cM
Region on 17q21.3 Often and Commonly Deleted in Tumors. Cancer Research, 53:3382-3385,
1993
E. Takahashi, K. Koyama, S. Hitomi, and Y. Nakamura: A high-resolution cytogenetic map of
human chromosome 12: localization of 195 new cosmid markers by direct R-banding
fluorescence in situ hybridization. Human Genetics, 92:405-409, 1993
H. Han, A. Yanagisawa, Y. Kato, J. Park, and Y. Nakamura: Genetic instability in pancreatic
cancer and poorly differentiated type of gastric cancer. Cancer Research, 53:5087-5089, 1993
H. Nagase and Y. Nakamura: Mutations of the APC (adenomatous polyposis coli) gene. Human
Mutation, 2:425-434, 1993
T. Tokino, N. Davidson, K. Helzlsour, B. Zehnhauer, Y. Nakamura, B. Vogelstein, and D.
Sidransky: Absence of germline prohibitin mutations in early onset breast cancer. International
Journal of Oncology, 3:769-772, 1993
S. Nakatsuru, A. Yanagisawa, Y. Furukawa, S. Ichii, Y. Kato, Y. Nakamura, and A. Horii: Somatic
mutations of the APC gene in precancerous lesion of the stomach. Human Molecular Genetics,
2:1463-1465, 1993
M. Konishi, R. Kikuchi-Yanoshita, K. Tanaka, C. Sato, K. Tsuruta, Y. Maeda, M. Koike, S. Tanaka,
Y. Nakamura, N. Hattori, and M. Miyaki: Genetic changes and histopathological grades in human
hepatocellular carcinomas. Japanese Journal of Cancer Research, 84:893-899, 1993
M. Emi, T. Katagiri, Y. Harada, H. Saito, J. Inazawa, I. Ito, F. Kasumi, and Y. Nakamura: A novel
metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast
cancers. Nature Genetics, 5:151-157, 1993
W. Liu, M. Piechocki, V. Shridhar, G. Lyles, Z. Song, Y. Nakamura, H. Drabkin, J. Vance, and D.I.
Smith: The isolation of a yeast artificial chromosome (YAC) contig extending for 2 megabases in
the vicinity of the Von Hippel Lindau disease gene. Human Molecular Genetics, 2:1177-1182,
1993
H.-J. Han, T. Fujiwara, S. Shin, and Y. Nakamura: Dinucleotide repeat polymorphisms in the 3'
non-coding region of the FLT1 gene. Human Molecular Genetics, 2:2204, 1993
T. Toda, M. Segawa, Y. Nomura, I. Nonaka, K. Masuda, T. Ishihara, M. Suzuki, I. Tomita, Y.
Origuchi, K. Ohno, N. Misugi, Y. Sasaki, K. Takada, M. Kawai , K. Ohtani, T. Murkami, K. Saito, Y.
Fukuyama, T. Shimizu, I. Kanazawa, and Y. Nakamura: Localization of a gene for Fukuyama type
congenital muscular dystrophy (FCMD) to chromosome 9q31-33. Nature Genetics, 5:283-286,
1993
R.J. Sinke, A. Tanigami, Y. Nakamura, and A. Geurts van Kessel: Reverse mapping of the gene
encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13. Genomics,
18:165, 1993
T. Tohma, T. Tamura, T. Ohta, H. Soejima, T. Kubota, Y. Jinno, K. Tsukamoto, Y. Nakamura, K.
Naritomi, and N. Niikakwa: Cosmid clones from microdissected human chromosomal region
15q11-q13. Japanese Journal of Human Genetics, 38:267-275, 1993
M.E. Phipps, E.R. Maher, N.A. Affara, F. Latif, M.A. Leversha, M.E. Fergusonsmith, Y. Nakamura,
M. Lerman, B. Zbar, and M.A. Fergusonsmith: Physical mapping of chromosome 3p25-p26 by
fluorescence in-situ hybridization (fish). Human Genetics, 92:18-22, 1993
W. Bruening, P. Gros, T. Sato, J. Stanimir, Y. Nakamura, D. Housman, and J. Pelletier Analysis of
the 11p13 Wilms' Tumor Suppressor Gene (WTI) in Ovarian Tumors Cancer Investigation,
4:393-399, 1993
228. E.R. Maher, D.E. Barton, R . Slatter, D.J. Koch, M.H. Jones, H. Nagase, S. Payne, S.J. Charles,
A.T. Moore, Y. Nakamura, and M.A. Ferguson-Smith: Evaluation of molecular genetic diagnosis
in the management of familial adenomatous polyposis coli: a population based study. Journal of
Medical Genetics, 30:675-678, 1993
229. A. Kurimasa, Y. Nagata, M. Emi, Y. Nakamura, and M. Oshimura: A human gene that restores the
DNA-repair defect in SCID mice is located on 8p11.1-q11.1. Human Genetics, 93:21-26, 1994
230. K. Yoshiura, J. Inazawa, K. Koyama, Y. Nakamura, and N. Niikawa: Mapping of the 8q
translocation breakpoint of t(8;13) observed in a patient with multiple exostoses. Genes
231. Y. Nakamura, K. Okui, E. Takahashi, and K. Koyama: Isolation and mapping of 328 new cosmid
markers on human chromosome 8: construction of a high resolution cytogenetic map of
chromosome 8 with 416 markers. Cytogenetics Cell Genetics, 65:115-118, 1994
232. Y. Furukawa, S. Nakatsuru, A. Nagafuchi, S. Tsukita, T. Muto, Y. Nakamura, and A. Horii:
Structure, expression and chromosome assignment of the human catenin(cadherin-associated
protein) alpha 1 gene(CTNNA1). Cytogenetics Cell Genetics, 65:74-78, 1994
233. J. Inazawa, T. Ariyama, T. Tokino, A. Tanigami, Y. Nakamura, and T. Abe: High-resolution
ordering of DNA markers by multi-color fluorescent in situ hybridization of prophase
chromosomes. Cytogenetics Cell Genetics, 65:130-135, 1994
234. M. Isomura, A. Tanigami, H. Saito, Y. Harada, T. Katagiri, J. Inazawa, D.H. Ledbetter, and Y.
Nakamura: Detailed analysis of loss of heterozygosity on chromosome band 17p13 in breast
carcinoma on the basis of a high-resolution physical map with 29 markers. Genes Chromosomes
and Cancer, 9:173-179, 1994
235. T. Mori, H. Nagase, A. Horii, Y. Miyoshi, S. Nakatsuru, T. Aoki, H. Arakawa, A. Yanagisawa, Y.
Ushio, S. Takano, M. Ogawa, M. Nakamura, M. Shibuya, R. Nishikawa, M. Matsutani, Y. Hayashi,
H. Takahashi, F. Ikuta, T. Nishihira, S. Mori, and Y. Nakamura: Germ-line and somatic mutations
of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.
236. K. Tsukamoto, Y. Nakamura, and N. Niikawa: Isolation of two isoforms of the PAX3 gene
transcripts and their tissue-specific alternative expression in human adult tissues. Human
Genetics, 93:270-274, 1994
237. R.J. Sinke, D. Olde Weghuis, R.F. Suijkerbuijk, A. Tanigami, Y. Nakamura, C. Larsson, G. Weber,
B. de Jong, J.W. Oosterhuis, W.A. Molenaar, and A. Geurts van Kessel: Molecular
characterization of a recurring complex chromosomal translocation in two human extragonadal
germ cell tumors. Cancer Genetics Cytogenetics, 73:11-16, 1994
238. Y. Fujiwara, H. Ohata, M. Emi, K. Okui, K. Koyama, E. Tsuchiya, M. Monden, T. Mori, A.
Kurimasa, M. Oshimura, and Y. Nakamura: A 3-Mb physical map of the chromosome region
8p21.3-p22, including a 600-kb region commonly deleted in human hepatocellular carcinoma,
colorectal cancer, and non-small cell lung cancer. Genes Chromosomes and Cancer, 10:7-14,
1994
239. M.H. Jones, S. Koi, I. Fujimoto, K. Hasumi, K. Kato, and Y. Nakamura: Allelotype of Uterine
cancer by analysis of RFLP and microsatellite polymorphisms: Frequent loss of heterozygosity on
chromosomes arms 3p, 9q, 10q, and 17p. Genes Chromosomes and Cancer, 9:119-123, 1994
240. T. Aoki, S. Takeda, A. Yanagisawa, Y. Kato, Y. Ajioka, H. Watanabe, S. Kudo, and Y. Nakamura:
APC and p53 mutations in de novo colorectal adenocarcinomas. Human Mutation, 3:342-346,
1994
241. O. Takeda, C. Homma, N. Maseki, M. Sakura, N. Kanda, M. Schwab, Y. Nakamura, and Y.
Kaneko: There may be two tumor suppressor genes on chromosome arm 1p closely associated
with biologically distinct subtypes of neuroblastoma. Genes Chromosomes and Cancer, 10:30-39,
1994
242. T. Aoki, T. Mori, D. XiQun, T. Nishihira, T. Matsubara, and Y. Nakamura: Allelotype study of
esophageal carcinoma. Genes Chromosomes and Cancer, 10:177-182, 1994
243. T. Toda, A. Iida, T. Miwa, Y. Nakamura, and T. Imai: Isolation and characterization of a novel
gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia
type 1 (MEN1). Human Molecular Genetics, 3:465-470, 1994
244. H. Tsuda, D.F. Callen, T. Fukutomi, Y. Nakamura, and S. Hirohashi: Allele loss on chromosome
16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and
extent of spread. Cancer Research, 54:513-517, 1994
245. H. Arakawa, N. Hayashi, H. Nagase, M. Ogawa, and Y. Nakamura: Alternative splicing of the NF2
gene and its mutation analysis of breast and colorectal cancers. Human Molecular Genetics,
3:565-568, 1994
246. T. Mori, T. Aoki, T. Matsubara, F. Iida, D. XiQun, T. Nishihira, S. Mori, and Y. Nakamura:
Frequent loss of heterozygosity in the region including BRCA1 on chromosome 17q in squamous
cell carcinomas of the esophagus. Cancer Research, 54:1638-1640, 1994
247. K. Koyama, K. Sudo, and Y. Nakamura: Mapping of the human nicotinic acetylcholine receptor β3
Gene (CHRNB3) within Chromosome 8p11.2. Genomics, 21:460-461, 1994
248. E. Arai, T. Ikeuchi, and Y. Nakamura: Characterization of the translocation breakpoint on
chromosome 22q12.2 in a patient with neurofibromatosis type 2 (NF2). Human Molecular
Genetics, 3:937-939, 1994
249. E. Takahashi, K. Koyama, A. Hitomi, H. Itoh, and Y. Nakamura: A high-resolution cytogenetic
map of human chromosome 9: Localization of 203 new cosmid markers by direct R-banding
fluorescence in situ hybridization. Genomics, 19:373-375, 1994
250. H. Arakawa, H. Nagase, N. Hayashi, T. Fujiwara, M. Ogawa, S. Shin, and Y. Nakamura:
Molecular cloning and expression of a novel human gene that is highly homologous to human
FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced
transcripts. Biochemical and Biophysical Research Communications, 200:836-843, 1994
251. N. Iwai, N. Ohmichi, K. Hanai, Y. Nakamura, and M. Kinoshita: Human SA gene locus as a
candidate for essential hypertension. Hypertension, 23:375-380, 1994
252. M. Mannens, J.M.N. Hoovers, E. Redeker, M. Verjaal, A.P. Feinberg, P. Little, M. Boavida, N.
Coad, M. Steenman, J. Bliek, N. Niikawa, H. Tonoki, Y. Nakamura, E.G. de Boer, R.M. Slater, R.
John, J.K. Cowell, C. Junien, I. Henry, R. Weksberg, S.M. Pueshel, N.J. Leschot, A. Westerveld:
Parental imprinting of human chromosome region 11p15.3-pter involved in the
Beckwith-Wiedemann syndrome and various human neoplasia. Eur. J. Human Genetics, 2:3-23,
1994
253. N. Uhrhammer, P. Concannon, Y. Huo, Y. Nakamura, and R.A. Gatti: A pulsed-field gel
electrophoresis map in the ataxia-telangiectasia region of chromosome 11q22.3. Genomics,
20:278-280, 1994
254. M. Nishiyama, J. Inazawa, T. Ariyama, Y. Nakamura, S. Matsufuji, A. Furusawa, T. Tanaka, S.
Hayashi, and J.R. Wands: The human insulin receptor substrate-1 gene (IRS1) is localized on
2q36. Genomics, 20:139-141, 1994
255. N. Hayashi, H. Arakawa, H. Nagase, M. Ogawa, and Y. Nakamura: Genetic diagnosis identifies
occult lymph node metastases undetectable by the histopathological method. Cancer Research,
54:3853-3856, 1994
256. T. Tanaka, K. Nakahara, N. Kato, T. Imai, T. Yamazaki, R. Nagai, Y. Yazaki, and Y. Nakamura:
Genetic linkage analyses of Romano-Ward syndrome (RWS) in 13 Japanese families. Human
Genetics, 94:380-384, 1994
257. K. Hibi, K. Yamakawa, R. Ueda, Y. Horio, Y. Murata, M. Tamari, K. Uchida, T. Takahashi, Y.
Nakamura, and T. Takahashi: Aberrant upregulation of a novel integrin α subunit gene at 3p21.3
in small cell lung cancer. Oncogene, 9:611-619, 1994
258. S. Hosoe, K. Ueno, Y. Shigedo, I. Tachibana, T. Osaki, T. Kumagai, Y. Tanio, I. Kawase, Y.
Nakamura, and T. Kishimoto: A frequent deletion of chromosome 5q21 in advanced small cell
and non-small cell carcinoma of the lung. Cancer Research, 54:1787-1790, 1994
259. Y. Harada, T. Katagiri, I. Itoh, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi:
Genetic studies of 457 breast cancers; clinicopathological parameters compared with genetic
alterations. Cancer, 74:2281-2286, 1994
260. Y. Murata, M. Tamari, T. Takahashi, Y. Horio, K. Hibi, S. Yokoyama, J. Inazawa, K. Yamakawa,
A. Ogawa, T. Takahashi and Y. Nakamura: Characterization of an 800 kb region at 3p22-p21.3
that was homozygously deleted in a lung cancer cell line. Human Molecular Genetics,
3:1341-1344, 1994
261. T. Ichikawa, N. Nihei, H. Suzuki, M. Oshimura, M. Emi, Y. Nakamura, I. Hayata, J.T. Isaacs, and J.
Shimazaki: Suppression of metastasis of rat prostatic cancer by introducing human chromosome
8. Cancer Research, 54:2299-2302, 1994
262. A. Horii, H.-J. Han, M. Shimada, A. Yanagisawa, Y. Kato, H. Ohta, W. Yasui, E. Tahara, and Y.
Nakamura: Frequent replication errors at microsatellite loci in tumors of patients with multiple
primary cancers. Cancer Research, 54:3373-3375, 1994
263. T. Mori, K. Miura, T. Aoki, T. Nishihira, S. Mori, and Y. Nakamura: Frequent somatic mutation of
the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in
esophageal squamous cell carcinoma. Cancer Research, 54:3396-3397, 1994
264. S. Nakatsuru, K. Sudo, and Y. Nakamura: Molecular cloning of a novel human cDNA homologous
to CDC10 in Saccharomyces cerevisiae. Biochemical and Biophysical Research
Communications, 202:82-87, 1994
265. S. Hosoe, Y. Shigedo, K. Ueno, I. Tachibana, T. Osaki, Y. Tanio, I. Kawase K. Yamakawa, Y.
Nakamura, and T. Kishimoto: Detailed deletion mapping of the short arm of chromosome 3 in
small cell and non-small cell carcinoma of the lung. Lung Cancer, 10:297-305, 1994
266. T. Toda, S. Ikegawa, K. Okui, E. Kondo, K. Saito, Y. Fukuyama, I. Kanazawa, and Y. Nakamura:
Refined mapping of a gene responsible for Fukuyama-type congenital muscular dystrophy;
evidence for a strong linkage disequilibrium. Am. J. Human Genetics, 55:946-950, 1994
267. N. Hayashi, Y. Sugimoto, E. Tsuchiya, M. Ogawa, and Y. Nakamura: Somatic mutations of the
MTS (multiple tumor suppressor) 1/ CDK4I (cyclin-dependent kinase-4inhibitor) gene in human
primary non-small cell lung carcinomas. Biochemical and Biophysical Research Communications,
202:1426-1430, 1994
268. T. Tanaka, K. Okui, and Y. Nakamura: Assignment of the human caltractin gene (CALT) to Xq28
by fluorescence in situ hybridization. Genomics, 24:609-610, 1994
269. C.A. Westbrook, M.M. Le Beau, W.L. Neuman, M. Keinanen, L.H. Yamaoka, M.C. Speer, R.
EspinosaIII, Y. Nakamura, R. Williamson, M. Mullan, and K. Buetow: Physical and genetic map
of 5q31: use of fluorescence in situ hybridization data to identify errors in the CEPH database.
Cytogenetics Cell Genetics, 67:86-93, 1994
270. K. Sudo, K. Chinen, and Y. Nakamura: 2,058 expressed sequence tags (ESTs) from a human
fetal lung cDNA library. Genomics, 24:276-279, 1994
271. T. Mori, A. Yanagisawa, Y. Kato, K. Miura, T. Nishihira, S. Mori, and Y. Nakamura: Accumulation
of genetic alterations during esophageal carcinogenesis. Human Molecular Genetics,
3:1969-1971, 1994
272. M.H. Jones, T. Sato, H. Saito, A. Tanigami, and Y. Nakamura: Six microsatellite polymorphisms
at candidate and confirmed tumour suppressor gene loci. Human Molecular Genetics, 3:1911,
1994
273. T. Sakamoto, N. Okamoto, Y. Ikeda, Y. Nakamura, and T. Sato: Dinucleotide-repeat
polymorphism in DNA of rainbow trout and its application in fisheries science. J. Fish Biol.,
44:1093-1096, 1994
274. J.-G. Park, H.-J. Han, M.-S. Kang, and Y. Nakamura: Presymptomatic diagnosis of familial
adenomatous polyposis coli. Diseases of Colon and Rectum, 37:700-707, 1994
275. H. Ohata, Y. Fujiwara, K. Koyama, and Y. Nakamura: Mapping of the human autoantigen
pericentriol material 1 (PCM1) gene to chromosome 8p21.3-p22. Genomics, 94:404-405, 1994
276. M.R. James, C.W. Richard, J. Schott, C. Yousry, K. Clark, J. Bell, J.D. Terwilliger, J. Hazan, C.
Dubay, A. Vignal, M. Agrapart, T. Imai, Y. Nakamura, M. Polymeropoulos, J. Weissenbach, D.R.
Cox, and G.M. Lathrop: A radiation hybrid map of 506 STS markers spanning human
chromosome 11. Nature Genetics, 8:70-76, 1994
277. S. Sato, Y. Nakamura, and E. Tsuchiya: Difference of allelotype between squamous cell
carcinoma and adenocarcinoma of the lung. Cancer Research, 54:5652-5655, 1994
278. A. Horii, H.-J. Han, S. Sasaki, M. Shimada and Y. Nakamura: Cloning, characterization and
chromosomal assignment of the human genes homologous to yeast PMS1, a member of
mismatch repair genes. Biochemical and Biophysical Research Communications, 204:1257-1264,
1994
279. M.J. Higgins, N.J. Smilinich, S. Sait, A. Koenig, J. Pongratz, M. Gessler, C.W. Richard, M.R.
James, J.P. Sanford, B.-W. Kim, J. Cattelane, N.J. Nowak, C. Jones, Y. Nakamura, D.S. Gerhard,
and T.B. Shows: An ordered NotI fragment map of human chromosome band 11p15. Genomics,
23:211-222, 1994
280. S. Baba, H. Ando, Y. Nakamura: Identification of germ line mutation of APC gene in possible
carriers of familial adenomatous polyposis (FAP). Anticancer Res., 14:2189-2192, 1994
281. P.J. Eubanks, M.P. Sawicki, G.J. Samara, R. Gatti, Y. Nakamura, D. Tsao, C. Johnson, M.
Hurwitz, Y.-J.Y. Wan, E. Passaro Jr: Putative tumor-suppressor gene on chromosome 11 is
important in sporadic endocrine tumor formation The American Journal of Surgery, 167:180-185,
1994
282. E. Takahashi, K. Koyama, M. Hirai, H. Itoh, and Y. Nakamura: A high-resolution cytogenetic map
of human chromosome 2: Localization of 434 cosmid markers by direct R-banding fluorescence
in situ hybridization. Cytogenetics Cell Genetics, 68:112-114, 1995
283. S. Nakatsuru, K. Sudo, and Y. Nakamura: Isolation and mapping of a human gene (MCM2)
encoding a product homologous to yeast proteins involved in DNA replication. Cytogenetics Cell
Genetics, 68:226-230, 1995
284. Y. Fujiwara, H. Ohata, T. Kuroki, K. Koyama, E. Tsuchiya, M. Monden, and Y. Nakamura:
Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous
to an extracellular domain of the PDGF receptor beta gene. Oncogene, 10:891-895, 1995
285. T. Katagiri, Y. Harada, M. Emi and Y. Nakamura: Human metalloprotease/disintegrin-like (MDC)
gene: exon-intron organization and alternative splicing. Cytogenetics Cell Genetics, 68:39-44,
1995
286. H. Arakawa, H. Nagase, N. Hayashi, M. Ogawa, M. Nagata, T. Fujiwara, E. Takahashi, S. Shin
and Y. Nakamura: Molecular cloning, characterization, and chromosomal mapping of a novel
human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA.
287. T. Ariyama, J. Inazawa, T. Ezaki, Y. Nakamura, A. Horii, and T. Abe: High-resolution cytogenetic
mapping of the short arm of chromosome 1 with newly isolated 411 cosmid markers by
fluorescence in situ hybridization: The precise order of 18 markers on 1p36.1 on prophase
chromosomes and "stretched" DNAs. Genomics, 25:114-123, 1995
288. Y. Hasegawa, S. Takeda, S. Ichii, K. Koizumi, M. Maruyama, A. Fujii, H. Ohta, T. Nakajima, M.
Okuda, S. Baba, and Y. Nakamura: Detection of K-ras mutations in DNAs isolated from feces of
patients with colorectal tumors by mutant-allele-specific amplification (MASA) . Oncogene,
10:1441-1445, 1995
289. I. Ito, M. Yoshimoto, T. Iwase, S. Watanabe, T. Katagiri, Y. Harada, F. Kasumi, S. Yasuda, T.
Mitomi, M. Emi, and Y. Nakamura: Association of genetic alterations on chromosome 17 with loss
of hormone receptors in breast cancer. British Journal of Cancer, 71:438-441, 1995
290. K. Chinen, K. Sudo, E. Takahashi, and Y. Nakamura: Isolation and mapping of the human
beta-signal sequence receptor gene (SSR2). Cytogenetics Cell Genetics, 70:215-217, 1995
291. T. Kawakami, Y. Furukawa, K. Sudo, H. Sait, E. Takahashi, and Y. Nakamura: Isolation and
mapping of a human gene (PDCD2) that is highly homologous to PR8, a rat gene associated with
programmed cell death. Cytogenetics Cell Genetics, 71:41-43, 1995
292. H.-J. Han, M. Maruyama, S. Baba, J.-G. Park, and Y. Nakamura: Genomic structure of human
mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis
colorectal cancer (HNPCC). Human Molecular Genetics, 4:237-242, 1995
293. T. Ariyama, T. Kimura, K. Yamakawa, Y. Nakamura, T. Abe, and J. Inazawa: Precise ordering of
26 cosmid markers on chromosome region 3p23 --> p21.3 by two-color FISH on human prophase
chromosomes and stretched DNAs. Cytogenetics Cell Genetics, 70:129-133, 1995
294. T. Ariyama, J. Inazawa, Y. Uemura, N. Kakazu, T. Maekawa, F. Urase, K. Irimajiri, A. Horiuchi., Y.
Nakamura, and T. Abe: Clonal origin of Philaderphia chromosome negative cells with trisomy 8
appearing during the course of α-interferon therapy for Ph positive chronic myolocytic leukemia.
Cancer Genetics Cytogenetics, 81:20-23, 1995
295. M. Kai, H. Arakawa, Y. Sugimoto, Y. Murata, M. Ogawa, and Y. Nakamura: Infrequent somatic
mutation of the MTS1 gene in primary bladder carcinomas. Japanese Journal of Cancer
Research, 86:249-251, 1995
296. K. Koyama, K. Sudo, and Y. Nakamura: Isolation of 115 human chromosome 8-specific
expressed-sequence tags by exon amplification. Genomics, 26:245-253, 1995
297. S. Ikegawa, K. Sudo, K. Okui, and Y. Nakamura: Isolation, characterization and chromosomal
assignment of human colligin-2 gene (CBP2). Cytogenetics Cell Genetics, 71:182-186, 1995
298. S. Ikegawa, Y. Fukushima, M. Isomura, F. Takada and Y. Nakamura: Mutations of the fibroblast
growth factor receptor-3 gene in one familial and six sporadic cases of achondroplasia in
Japanese patients. Human Genetics, 96:309-311, 1995
299. N.K. Spurr, S. Blanton, R. Bookstein, R. Clarke, R. Cottingham, S.Daiger, D. Drayna, P. Faber, S.
Horrigan, K. Kas, C. Kirchgessner, S. Kumar, R.J. Leach, J-J. Luedecke, Y. Nakamura, M-J.
Pebusque, S. Ranta, E. Sim, L.S. Sullivan, L. Takle, J. Vance, M. Wagner, D. Wells, C.
Westbrook, L. Yaremko, D. Zaletayev, O. Zuffardi, and S. Wood: Report and abstracts of the
second international workshop on human chromosome 8 mapping 1994. Cytogenetics Cell
Genetics, 68:147-164, 1995
300. A. Iida, K. Blake, T. Tunny, S. Klemm, M. Stowasser, N. Hayward, R. Gordon, Y. Nakamura, and
T. Imai: Allelic losses on chromosome band 11q13 in aldosterone-producing adrenal tumors.
301. T. Kuroki, Y. Fujiwara, E. Tsuchiya, S. Nakamori, Y. Imaoka, T. Kanematsu, and Y. Nakamura:
Accumulation of genetic changes during development and progression of hepatocellular
carcinoma: LOH on chromosome arm 1p occurs at an early stage of hepatocarcinognesis. Genes
302. N. Hayashi, I. Ito, A. Yanagisawa, Y. Kato, S. Nakamori, S. Imaoka, H. Watanabe, M. Ogawa, and
Y. Nakamura: Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet,
345:1257-1259, 1995
303. N. Hashimoto, D. Ichikawa, Y. Arakawa, K. Date, S. Ueda, Y. Nakagawa, A. Horii, Y. Nakamura,
T. Abe, and J. Inazawa: Frequent deletions of material from chromosome arm 1p in
oligodendroglial tumors revealed by double-target fluorescence in situ hybridization and
microsatellite analysis. Genes Chromosomes and Cancer, 14:295-300, 1995
304. K. Miura, K. Okita, Y. Furukawa, S. Matsuno, and Y. Nakamura: Deletion mapping in squamous
cell carcinomas of the esophagus defines a region containing a tumor suppressor gene within a
4-cM interval of the distal long arm of chromosome 9. Cancer Research, 55:1828-1830, 1995
305. T. Toda, M. Yoshioka, Y. Nakahori, I. Kanazawa, Y. Nakamura, and Y. Nakagome: Genetic
identity of Fukuyama-type congenital muscular dystrophy and Walker-Warburg syndrome. Ann.
Neurol, 37:99-101, 1995
306. H. Soejima, K. Yoshiura, T. Tamura, T. Tokino, Y. Nakamura, Y. Niikawa, and Y. Jinno: Fifty
novel sequences-tagged sites (STSs) on human chromosome 11q13.4-q25 identified from
microclones generated by microdissection. Cytogenetics Cell Genetics, 70:108-111, 1995
307. S. Inoue, A. Orimo, Y. Matsuda, J. Inazawa, M. Emi, Y. Nakamura, T. Hori, and M. Muramatsu:
Chromosomal mapping of human (ZNF147) and mouse genes for estrogen-responsive finger
protein (efp), a member of the RING finger family. Genomics, 25:581-583, 1995
308. T. Kuroki, Y. Fujiwara, S. Nakamori, Y. Imaoka, T. Kanematsu, and Y. Nakamura: Evidence for
the presence of two tumor-suppressor genes for hepatocellular carcinoma on chromosome 13q.
British Journal of Cancer, 72:383-385, 1995
309. M. Shimada, A. Horii, S. Sasaki, A. Yanagisawa, Y. Kato, K. Yamashita, K. Okagawa, K.
Yamasaki, S. Ishiguro, M. Inoue, H. Shiozaki, and Y. Nakamura: Infrequent replication errors at
microsatellite loci in tumors of patients with multiple primary cancers of the esophagus and
various other tissues. Japanese Journal of Cancer Research, 86:511-515, 1995
310. K. Sudo, E. Takahashi, and Y. Nakamura: Isolation and mapping of human EIF4A2 gene
311.
312.
313.
314.
315.
316.
317.
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319.
320.
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homologous to the murine protein synthesis initiation factor 4A-II gene eIF4A-II. Cytogenetics Cell
Genetics, 71:385-388, 1995
K. Kobayashi, S. Sagae, R. Kudo, H. Saito, S. Koi, and Y. Nakamura: Microsatellite instability in
endometrial carcinomas; frequent replication errors in tumors of early onset and/or of poorly
differentiated type. Genes Chromosomes and Cancer, 14:128-132, 1995
M. Matsushima, K. Kobayashi, M. Emi, H. Saito, J. Saito, K. Suzumori, Y. Nakamura: Mutations
analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients; four germline mutations, but
no evidence of somatic mutation. Human Molecular Genetics, 4:1953-1956, 1995
H. Suzuki, M. Emi, A. Komiya, Y. Fujiwara, R. Yatani, Y. Nakamura, and J. Shimazaki:
Localization of a tumor suppressor gene associated with progression of human prostate cancer
within a 1.2 Mb region of 8p22-p21.3. Genes Chromosomes and Cancer, 13:168-174, 1995
T. Watanabe, T.Fujiwara, H. Shinomiya, Y. Kuga, H. Hishigaki, Y.Nakamura, and Y.Hirai:
Molecular cloning of a novel human cDNA, RT14, containing a putative ORF highly conserved
between human, fruit fly, and nematode. DNA Research, 2:235-237, 1995
T. Toda, S. Ikegawa, M. Miyake, Y. Nakahori, and Y. Nakamura: Dinucleotide repeat
polymorphism on chromosome 9q32. Japanese Journal of Human Genetics, 40:333-334, 1995
Y. Nakamura: The APC (Adenomatous Polyposis Coli) gene and human cancers. JCRCO,
121:529-534, 1995
T. Fujiwara, A. Kawai, F. Shimizu, H. Hirano, S. Okuno, S. Takeda, K. Ozaki, Y. Shimada, M.
Nagata, T. Watanabe, A. Takaichi, E. Takahashi, Y. Nakamura, and S. Shin: Cloning, sequencing
and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit). DNA
Research, 2:107-111, 1995
S. Takiguchi-Shirahama, K. Koyama, A. Miyauchi, T. Wakasugi, S. Oishi, H. Takami, K. Hikiji, and
Y. Nakamura: Germline mutations of the RET proto-oncogene in eight Japanese patients with
multiple endocrine neoplasia type 2A (MEN2A). Human Genetics, 95:187-190, 1995
R.M.W. Hofstra, T. Stelwagen, B. Pasini, A.Y. van der Veen, B. Ponder, Y. Nakamura, G. Romeo.
C.H.C.M. Buys: Ordering of markers in the pericentromeric region of chromosome 10. Human
Genetics, 96:116-118, 1995
J. Nahmias, N. Horinigold, J. Fitzgibbon, K. Woodward, A. Pilz, D. Griffin, E.P. Henske, Y.
Nakamura, S. Graw, F. Florian, F. Benham, S. Povey, and J. Wolfe: Cosmid contigs spanning
9q34 including the candidate region for TSC1. Eur. J. Human Genetics, 3:65-77, 1995
M. Litt, P. Kramer, E. Korte, P. Fain, S. Cox, D. Root, R. White, J. Weissenbach, H. Doniskeller,
R.Gatti, J. Weber, Y. Nakamura, C. Julier, K. hayashi, N. Supurr, M. Dean, J. Mandel, K. kidd, T.
Kruse, A. Retief, A. bale, T. Meo, G. Vergnaud, S. Warren, and H.F. Willard: The CEPH
consortium linkage map of human chromosome 11. Genomics, 27:101-112, 1995
E. Tsuchiya, R. Furuta, N. Wada, K. Nakagawa, Y. Ishikawa, B. Kawabuchi, Y. Nakamura, and H,
Sugano: High K.ros mutation rates in goblet-cell-type adenocarcinomas of the lungs J Cancer
Res Clin Oncol,, 122:577-581, 1995
N. Hayashi, S. Sugai, I. Ito, S. Nakamori, M. Ogawa, and Y. Nakamura: Ethnic difference in the
pattern of K-ras oncogene mutations in human colorectal cancers. Human Mutation, 8:258-261,
1996
M. Inoue, M. Isomura, S. Ikekawa, T. Fujiwara, S. Shin, H. Moriya, Y. Nakamura: Isolation and
characterization of a human cDNA clone (GCN5L1) homologous to GCN5, a yeast transcription
activator. Cytogenetics Cell Genetics, 73:134-136, 1996
Y. Furukawa, T. Kawakami, K. Sudo, J. Inazawa, A. Matsumine, T. Akiyama, Y. Nakamura:
Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription
factor in Saccharomyces cerevisiae. Cytogenetics Cell Genetics, 73:130-133, 1996
S. Sasaki, A. Horii, M. Shimada, H.-J. Han, A. Yanagisawa, T. Muto, and Y. Nakamura: Somatic
Mutations of a Human Mismatch Repair Gene, hMLH1, in Tumors from Patients with Multiple
Primary Cancers. Human Mutation, 7:275-278, 1996
T. Katagiri, M. Emi, I. Ito, K. Kobayashi, M. Yoshimoto, S. Watanabe, T. Iwase, F. Kasumi, Y. Miki,
M.H. Skolnick, and Y. Nakamura: Mutations in the BRCA1 gene in Japanese breast cancer
patients. Human Mutation, 7:334-339, 1996
H. Saito, T. Fujiwara, S. Shin, K. Okui, and Y. Nakamura: Cloning and mapping of a human novel
cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2.
T. Ezaki, M. Watanabe, T. Hibi, S. Aiso, K. Ohta, T. Nakajima, A. Yanagisawa, Y. Kato, T.
Ariyama, J. Inazawa, Y. Nakamura and A. Horii: Deletion mapping on chromosome 1p in
well-differentiated gastric cancer. British Journal of Cancer, 73:424-428, 1996
H. Saito, T. Fujiwara, E. Takahashi, S. Shin, and Y. Nakamura: Isolation and mapping of a novel
human gene encoding a protein containing zinc-finger structures. Genomics, 31:376-379, 1996
K. Koyama, Y. Fukushima, J. Inazawa, N. Takahashi, and Y. Nakamura: The human homologue
of the murine Llglh gene (LLGL) maps within the Smith-Magenis Syndrome region in 17p11.2.
M. Isomura, K. Okui, T. Fujiwara, S. Shin, and Y. Nakamura: Cloning and mapping of a novel
human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary
gene. Genomics, 32:125-127, 1996
333. H.-J. Han, K. Sudo, J. Inazawa, and Y. Nakamura: Isolation and mapping of a human gene
(RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene.
334. K. Kobayashi, M. Matsushima, S Koi, H. Saito, S. Sagae, R. Kudo and Y. Nakamura: Mutational
analysis of mismatch repair genes, hMLH1 and hMSH2, in sporadic endometrial carcinomas with
microsatellite instability. Japanese Journal of Cancer Research, 87:141-145, 1996
335. T. Tanaka, J. Inazawa, and Y. Nakamura: Molecular cloning and mapping of a human cDNA for
cytosolic malate dehydrogenase (MDH1). Genomics, 32:128-130, 1996
336. S. Ninomiya, M. Isomura, K, Narahara, Y. Seino, and Y. Nakamura: Isolation of a testis-specific
cDNA on chromosome 17q from a region adjacent to the breakpoint of t(12;17) observed in a
patient with acampomelic campomelic dysplasia and sex reversal. Human Molecular Genetics,
5:69-72, 1996
337. T. Watanabe, T.Fujiwara, A. Kawai, F. Shimizu, S. Takami, H. Hirano, S. Okuno, K. Ozaki, S.
Takeda, M. Nagata, A. Takaichi, E.Takahashi, Y.Nakamura, and S. Shin: Cloning, expression,
and mapping of UBE2I, a novel gene encoding a human homologue of yeast
ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. Cytogenetics Cell
Genetics, 72:86-89, 1996
338. T. Katagiri, K. Ozaki, T. Fujiwara, F. Shimizu, A. Kawai, S. Okuno, M. Suzuki, Y. Nakamura, E.
Takahashi, and Y. Hirai: Cloning, expression and chromosome mapping of adducin-like 70
(ADDL), a human cDNA highly homologous to human erythrocyte adducin. Cytogenetics Cell
Genetics, 74:90-95, 1996
339. T. Tokino, T. Urano, T. Furuhata, M. Matsushima, T. Miyatsu, S. Sasaki, and Y. Nakamura:
Characterization of the human p57KIP2 gene; Alternative splicing, Insertion/deletion
polymorphisms in VNTR sequences in the coding region, and mutational analysis. Human
Genetics, 97:625-631, 1996
340. M. Shimada, A. Yanagisawa, Y. Kato, M. Inoue, H. Shiozaki, M. Monden and Y. Nakamura:
Genetic machanisms in esophageal carcinogenesis; frequent deletion of 3p and 17p in
premalignant lesions. Genes Chromosomes and Cancer, 15:165-169, 1996
341. T. Tanaka, J. Inazawa, Y. Nakamura: Molecular cloning of a human cDNA encoding putative
cysteine protease (PRSC1) and its chromosome assignment to 14q32.1. Cytogenetics Cell
Genetics, 74:120-123, 1996
342. T. Mori, K. Miura, T. Fujiwara, S. Shin, J. Inazawa, and Y. Nakamura: Isolation and mapping of a
human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse
DIFF6. Cytogenetics Cell Genetics, 73:224-227, 1996
343. K. Okita, T. Tokino, H. Nishimori, K. Miura, H. Nikaido, J. Hayakawa, A. Ono, M. Kuwajima, Y.
Matsuzawa and Y. Nakamura: Definition of the locus responsible for systemic carnitine deficiency
within a 1.6-cM region of mouse chromosome 11 by detailed linkage analysis. Genomics,
33:289-291, 1996
344. K. Chinen, E. Takahashi, and Y. Nakamura: Isolation and mapping of a novel gene (SEC14L),
partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR)
site in its 3' untranslated region. Cytogenetics Cell Genetics, 73:218-223, 1996
345. T. Ohta, M. Nakano, T. Tsujita, K. Abe, K. Osoegawa, T. Yamagata, K. Yoshiura, Y. Jinno, E.
Soeda, Y. Nakamura, and N. Niikawa: Isolation of a cosmid clone corresponding to an inv(21)
breakpoint of a patient with transient abnormal myelopoiesis. Am. J. Human Genetics,
58:544-550, 1996
346. K. Tsukamoto, N. Ito, M. Yoshimoto, T. Iwase, T. Tada, F. Kasumi, Y. Nakamura, and M. Emi:
Two distinct commonly deleted regions on chromosome 13q suggest involvement of BRCA2 and
retinoblastoma (RB) genes in sporadic breast carcinomas. Cancer, 78:1929-1934, 1996
347. K. Miura, K. Suzuki, T.Tokino, M. Isomura, J.Inazawa, S. Matsuno and Y. Nakamura: Detailed
deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a
putative tumor suppressor gene to about 200 kb on distal chromosome 9q. Cancer Research,
56:1629-1634, 1996
348. T. Tanaka, A. Ogiwara, I. Uchiyama, T. Takagi, and Y.Nakamura: Construction of a normalized
directionally-cloned cDNA library from adult heart and analysis of 3040 clones by partial
sequencing. Genomics, 35:231-235, 1996
349. T. Watanabe, F. Shimizu, M. Nagata, A. Kawai, T. Fujiwara, Y. Nakamura, E. Takahashi, Y.Hirai:
Cloning, expression, and mapping of CKAP1, which encodes a putative cytoskeleton-associated
protein containing a CAP-GLY domain. Cytogenetics Cell Genetics, 72:208-211, 1996
350. K. Ozaki, T. Kuroki, S. Hayashi, and Y. Nakamura: Isolation of three testis-specific genes
(TSA303, TSA806, TSA903) by a differential mRNA display method. Genomics, 36:316-319,
1996
351. S. Ikegawa, T. Toda, K. Okui and Y. Nakamura: Structure and chromosomal assignment of the
human S1-5 Gene (FBNL) that is highly homologous to fibrillin. Genomics, 35:590-592, 1996
352. M. Isomura, K. Okui, T. Fujiwara, S. Shin, and Y. Nakamura: Isolation and mapping of RAB2L, a
human cDNA that encodes a protein homologous to RalGDS. Cytogenetics Cell Genetics,
74:263-265, 1996
353. K. Ozaki, T. Fujiwara, A. Kawai, F. Shimizu, S. Takami, S. Okuno, S. Takeda, Y. Shimada, M.
Nagata, T. Watanabe, A. Takaichi, E. Takahashi, Y. Nakamura, and S. Shin: Cloning, expression
and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain.
354. S. Matuda, J.K. Tuzuki, M. Ohsugi, M. Yoshida, M. Emi, Y. Nakamura, Y. Yoshida, A.F.
Nishiyama and T. Yamamoto: Tob, a novel protein that interacts with p185erbB2, is associated
with anti-proliferative activity. Oncogene, 12:705-713, 1996
355. L.A. James, D.J. Ogilvie, K. Yamakawa, Y. Nakamura, C.J. Stirling, and R. Anand: Walking,
cloning, and mapping with YACs in 3q27: Localization of five ESTs including three members of
the cystatin gene family and identification of CpG island. Genomics, 32:425-430, 1996
356. D. Ichikawa, N. Hashimoto, M. Hoshima, T. Yamaguchi, K. Sawai, Y. Nakamura, T. Takahashi, T.
Abe, J. Inazawa: Analysis of numerical aberrations in specific chromosomes by fluorescence in
situ hybridization (FISH) as a diagnostic tool in breast cancer. Cancer, 77:2064-2069, 1996
357. A. Matsumine, T. Senda, G-H. Baeg, B.C. Roy, Y. Nakamura, M. Noda, K. Toyoshima, and T.
Akiyama: MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S
phase. Journal of Biological Chemistry, 271:10341-10346, 1996
358. Y. Nakamura: Application of DNA markers to clinical genetics. Japanese Journal of Human
Genetics, 41:1-10, 1996
359. T. Watanabe, T.Fujiwara, F.Shimizu, S.Okuno, M.Suzuki, E.Takahashi, Y.Nakamura, Y.Hirai:
Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to
6q. Cytogenetics Cell Genetics, 73:153-156, 1996
360. S. Ikegawa, Y. Kumano,K. Okui, T. Fujiwara, E. Takahashi and Y. Nakamura: Isolation,
characterization and chromosomal assignment of the human WNT7A gene. Cytogenetics Cell
Genetics, 74:149-152, 1996
361. Y. Miki, T. Katagiri, F. Kasumi, T. Yoshimoto and Y. Nakamura: Mutation analysis in the BRCA2
gene in primary breast cancers. Nature Genetics, 13:245-247, 1996
362. H.-J. Han, Y. Yuan, J.-L. Ku, J.-H. Oh, Y.-J. Won, K.J. Kang, K.Y. Kim, S. Kim, C.Y. Kim, J.-P.
Kim, N.G. Oh, K.H. Lee, K.J. Choe, Y. Nakamura, and J.-G. Park: Germline mutations of hMLH1
and hMSH2 genes in Korean HNPCC, suspected Hereditary Nonpolyposis Colorectal Cancer
(HNPCC). J. Natl. Cancer Inst., 88:1317-1319, 1996
363. I. Ishikawa, M. Ozaki, Y. Tominaga, and Y. Nakamura: Cytogenetic abnormalities in renal cell
carcinomas associated with uremic aquired renal cystic disease. J. Kanazawa Med. Univ.,
21:76-81, 1996
364. K. Wakui, H. Ohashi, A. Yamagishi, S. Hamano, T. Nara, S. Ishikiriyama, Y. Nakamura, and Y.
Fukushima: Insertional Duplication 8q22-q24: Report of a case proven by FISH with mapped
cosmid probes. American Journal of Medical Genetics, 65:36-39, 1996
365. M. Matsushima, J. Inazawa, E. Takahashi, K. Suzumori, and Y. Nakamura: Molecular cloning and
mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal
sterol-C5-desaturase. Cytogenetics Cell Genetics, 74:252-254, 1996
366. T. Katagiri, Y. Nakamura, and Y. Miki: Mutations in the BRCA2 gene in hepatocellular carcinomas.
367. T. Watanabe, F. Shimizu, M. Nagata, A. Takaichi, T. Fujiwara, Y. Nakamura, E. Takahashi, and
Y.Hirai: Cloning, expression pattern and mapping to 12p13.2-p13.1 of CLAPS3, a gene encoding
a novel clathrin-adaptor small chain. Cytogenetics Cell Genetics, 73:214-217, 1996
368. T. Furuhata, T. Urano, T. Tokino, and Y. Nakamura: Isolation of a novel GPI-anchored gene
specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity.
Oncogene, 13:1965-1970, 1996
369. T. Toda, M. Miyake, K. Kobayashi, K. Mizuno, K. Saito, M. Osawa, Y. Nakamura, I. Kanazawa, Y.
Nakagome, K. Tokunaga, and Y. Nakahori: Linkage disequilibrium mapping narrows the
Fukuyama-type congenital muscular dystrophy (FCMD) candidate region to less than 100 kb. Am.
J. Human Genetics, 59:1313-1320, 1996
370. F. Shimizu, T.K. Watanabe, T. Fujiwara, E. Takahashi, Y. Nakamura, and H. Maekawa: Isolation
and mapping of the human glycoprotein M6 gene (GMP6A) to 4q33 -->q34. Cytogenetics Cell
Genetics, 74:138-139, 1996
371. T. Watanabe, A. Kawai, T. Fujiwara, H. Maekawa, Y.Hirai, Y. Nakamura, and E. Takahashi:
Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating
enzyme homologous to UBC7 of C. elegans. Cytogenetics Cell Genetics, 74:146-148, 1996
372. T. Watanabe, T. Fujiwara, Y. Nakamura, Y. Hirai, H. Maekawa, and E. Takahashi: Cytogenet.
Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide
homologous to human and yeast nucleosome assembly proteins. Cytogenetics Cell Genetics,
74:281-285, 1996
373. S. Saito, S. Sirahama, M. Matsushima, M. Suzuki, S. Sagae, R. Kudo, J. Saito, K. Noda, and Y.
Nakamura: Definition of a commonly-deleted region in ovarian cancers to a 300-kb segment of
chromosome 6q27. Cancer Research, 15:5586-5589, 1996
374. T. Watanabe, T. Katagiri, M. Suzuki, F. Shimizu, T. Fujiwara, N. Kanemoto, Y. Nakamura, Y. Hirai,
375.
376.
377.
378.
379.
380.
381.
382.
383.
384.
385.
386.
387.
388.
389.
390.
391.
392.
393.
394.
395.
H. Maekawa, and E. Takahashi: Cloning and characterization of two novel human cDNAs (NELL1
and NELL2) encoding proteins with six EGF-like repeats. Genomics, 38:273-276, 1996
K. Chinen, M. Isomura, K. Izawa, Y. Fujiwara, H. Ohata, T. Iwamasa, and Y. Nakamura: Isolation
of 45 exon-like fragments from 8p22 --> p21.3, a region that is commonly deleted in
hepatocellular, colorectal, and non-small cell lung carcinomas. Cytogenetics Cell Genetics,
75:190-196, 1996
I.P.M. Tomlinson, S. Olschwang, D. Abelovitch, Y. Nakamura,W.F. Bodmer, G. Thomas, and D.
Markie: Testing candidate loci on chromosomes 1 and 6 for genetic linkage to Peutz-Jeghers'
disease Annals of Human Genetics , 60:377-384, 1996
S. Sasaki, T. Tokino, T. Miyatsu, T.Muto and Y. Nakamura: Mutational analysis of the hMLH1
gene using an automated two-dimensional DNA typing system. Human Mutation, 9:164-171,
1997
A. Iida, R. Isobe, M. Yoshimoto, T. Iwase, T. Tada, F. Kasumi, Y. Nakamura, and M. Emi:
Localization of a breast cancer tumor suppressor gene to a 3-cM interval within chromosomal
region 16q22. British Journal of Cancer, 75:264-267, 1997
H. Saito, S. Nakatsuru, J. Inazawa, and Y. Nakamura: Frequent association of alternative splicing
of NER, a nuclear hormone receptor gene, in cancer tissues. Oncogene, 14:617-621, 1997
S. Ishikawa, M. Kai, Y. Takei, K. Kuwata, K. Okui, M. Suzuki, M. Ogawa, and Y. Nakamura:
Isolation and mapping of a human zinc finger gene (ZNF188) homologous to ZNF187, a
serum-response-element binding protein. Cytogenetics Cell Genetics, 77:185-189, 1997
S. Ikegawa, K. Nakamura, A. Nagano, N. Haga, and Y. Nakamura: Mutations in the N-terminal
globular domain of the type X collagen gene (COL10A1) In patients with Schmid metaphyseal
chondrodysplasia. Human Mutation, 9:131-135, 1997
S. Matsumoto, F. Kasumi, G. Sakamoto, M. Onda, Y. Nakamura, and M. Emi: Detailed deletion
mapping of chromosome arm 3p in breast cancers: A 2-cM region on 3p14.3-21.1 and a 5-cM
region on 3p24.3-25.1 commonly deleted in tumors. Genes Chromosomes and Cancer,
20:268-274, 1997
T. Tanaka, R. Nagai, H. Tomoike, S. Takada, K. Yano, K. Yabuta, N. Haneda, O. Nakano,
A.Shibata, T.Sawayama, H. Kasai, Y. Yazaki, and Y. Nakamura: Four novel KVLQT1 and four
novel HERG mutations in familial long-QT syndrome. Circulation, 95:565-567, 1997
K. Suzuki, Y. Daigo, S. Fukuda, T. Tokino, M. Isomura, K. Isono, B. Wainwright, and Y.
Nakamura: No evidence of mutation in the human PTC gene, responsible for NBCC syndrome, in
human primary squamous cell carcinomas of the esophagus and lung. Japanese Journal of
JT. Lim, T. Kuroki, K. Ozaki, H. Kohsaki, T. Yamori, T. Tsuruo, S. Nakamori, S. Imaoka, M. Endo,
and Y. Nakamura: Isolation of murine and human homologues of the fission-yeast dis3+ gene
encoding a mitotic-control protein and its overexpression in cancer cells with progressive
phenotypes. Cancer Research, 57:921-925, 1997
Y. Kimura, T. Furuhata, T. Urano, K. Hirata, Y. Nakamura, and T. Tokino: Genomic structure and
chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53.
Genomics, 41:477-480, 1997
S. Ishikawa, M. Kai, M. Tamari, Y. Takei, K Takeuchi, H. Bandou, Y. Yamane, M. Ogawa, and Y.
Nakamura: Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is
homozygously deleted in a lung carcinoma cell line. DNA Research, 4:35-43, 1997
Y. Kimura, T. Furuhata, T. Shiratsuchi, H. Nishimori, K. Hirata, Y. Nakamura, and T. Tokino: GML
sensitizes cancer cells to Taxol by induction of apoptosis. Oncogene, 15:1369-1374, 1997
S. Ishikawa, T. Takahashi, M. Ogawa, and Y. Nakamura: Genomic structure of the human PLCD1
(phospholipase C delta 1) locus on 3p22 --> p21.3. Cytogenetics Cell Genetics, 78:58-60, 1997
S. Tamura, S. Nakamori, T. Kuroki, Y. Sasaki, S. Imaoka, H. Furukawa, O. Ishikawa, and Y.
Nakamura: Association of cumulative allelic losses with tumor agressiveness in hepatocellular
carcinoma. Journal of Hepatology, 27:669-676, 1997
Y. Daigo, K. Suzuki, O. Maruyama, Y. Miyoshi, T. Yasuda, T. Kabuto, S. Imaoka, T. Fujiwara, E
Takahashi, M. Fujino, and Y. Nakamura: Isolation, mapping, and mutation analysis of a human
cDNA homologous to the doc-1 gene of Chinese hamster, a candidate tumor suppressor for oral
cancer. Genes Chromosomes and Cancer, 20:204-207, 1997
T. Kimura, Y. Arakawa, S. Inoue, Y. Fukushima, I. Kondo, K. Koyama, T. Hosoi, A. Orimo, M.
Muramatsu, Y. Nakamura, T. Abe, and J. Inazawa: The brain finger protein gene (ZNF179), a
member of the ring finger family, maps within the Smith-Magenis syndrome region at 17p11.2.
American Journal of Medical Genetics, 69:320-324, 1997
Y. Nakamura:, Cleaning up on β-catenin. (News & Views) Nature Medicine, 3:499-500, 1997
Y. Miki, T. Katagiri, and Y. Nakamura: Infrequent Mutation of the H-cadherin Gene on
Chromosome 16q24 in Human Breast Cancers. Japanese Journal of Cancer Research,
88:701-704, 1997
S. Takeda, T. Fujiwara, F. Shimizu, A. Kawai, K. Shinomiya, S. Okuno, K. Ozaki, T. Katagiri, Y.
Shimada, M. Nagata, T. Watanabe, A. Takaichi, Y. Kuga, M. Shimizu, H. Hishigaki, E. Takahashi,
S. Shin, Y. Nakamura, and Y. Hirai: Isolation and mapping of karyopherin alpha3 (KPNA3), a
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human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and
human RCH1. Cytogenetics Cell Genetics, 76:87-93, 1997
S. Fukuda, H. Kohsaki, S. Hayashi, K.Ozaki, T.Kuroki ,T. Yamori, T. Tsuruo, S. Nakamori, S.
Imaoka and Y. Nakamura: Isolation of a novel gene showing a reduced expression in metastatic
colorectal carcinoma cell lines and carcionmas. Japanese Journal of Cancer Research,
88:725-731, 1997
F. Shimizu, T.K. Watanabe, S. Okuno, Y. Omori, T. Fujiwara, E. Takahashi, and Y. Nakamura:
Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. Biochem. Biophy. Acta,
1351:13-16, 1997
H. Chen, C. Rossier, Y. Nakamura, A. Lynn, A. Chakravarti, and S. Antonarakis: Cloning of a
novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3.
Genomics, 41:193-200, 1997
T. Urano, H. Nishimori, H.-J. Han, T. Furuhata, Y. Kimura, Y. Nakamura and T. Tokino: Cloning of
P2XM, a novel human P2X receptor gene regulated by p53. Cancer Research, 57:3281-3287,
1997
H. Nishimori, T. Shiratsuchi, T. Urano, Y. Kimura, K. Kiyono, K. Tatsumi, S. Yoshida, M. Ono, M.
Kuwano, Y. Nakamura, T. Tokino: A novel brain-specific p53-target gene, BAI1, containing
thrombospondin type1 repeats inhibits experimental angiogenesis. Oncogene, 15:2145-2150,
1997
S. Nakamori, M. Kameyama, H. Furukawa, O. Takeda, S. Sugai, S. Imaoka, and Y. Nakamura:
Genetic detection of colorectal cancer cells in circulation and lymph nodes. Diseases of Colon
and Rectum, 40:s29-s36, 1997
M. Nesbit, M. Hodges, L. Campbell, T. de Meulemeester, M. Alders, N. Rodrigues, K. Talbot, A.
Theodosiou, M. Mannens, Y. Nakamura, P. Little, and K.E. Davies: Genomic organization and
chromosomal localization of a member of the MAP kinase phosphatase gene family to human
chromosome 11p15.5 and a pseudogene to 10q11.2. Genomics, 42:284-294, 1997
F. Shimizu, T. Katagiri, M. Suzuki, T.K. Watanabe, S. Okuno, Y. Kuga, M. Nagata, T. Fujiwara, Y.
Nakamura and E. Takahashi: Cloning and chromosome assignment to 1q32 of a human cDNA
(RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily.
H. Shibata, K. Toyama, H. Shioya, M. Ito, M. Hirota, S. Hasegawa, H. Matsumoto, H. Takano, T.
Akiyama, K. Toyoshima, R. Kanamaru, Y. Kanegae, I. Saito, Y. Nakamura, K. Shiba, and T.
Noda: Rapid colorectal adenoma formation initiated by conditional targeting of the APC gene.
Science, 278:120-123, 1997
S. Ikegawa and Y. Nakamura: Structure of the gene encoding human colligin-2 (CBP2). Gene,
194:301-303, 1997
T. Yokota, S. Matsumoto, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura,
and M. Emi: Mapping of a breast cancer tumor supressor gene locus to a 4-cM interval on
chromosome 18q21. Japanese Journal of Cancer Research, 88:959-964, 1997
M. Nakamoto, H. Takebayashi, Y. Kawaguchi, S. Narumiya, M. Taniwaki, Y. Nakamura, K.
Ishikawa, I. Akiguchi, and J. Kimura, A. Kakizuka: A CAG/CTG expansion in the normal
population. Nature Genetics, 17:385-386, 1997
Y. Nakamura, T. Tokino, M. Isomura, J. Inazawa, T. Aoki, T. Mori, M. Shimada, K. Miura, and K.
Suzuki: Multistep carcinogenesis of Esophageal Carcinoma. Molecular Pathology of
Gastroenterological Cancer, :15-22, 1997
M. Emi, S. Matsumoto, A. Iida, K. Tsukamoto, T. Nakata, T. Yokota, F. Akiyama, G. Sakamoto, M.
Yoshimoto, F. Kasumi, and Y. Nakamura: Correlation of allelic losses and clinicopathological
factors in primary breast cancers. Breast Cancer, 4:243-246, 1997
F. Shimizu, T.K. Watanabe, H. Shimomiya, Y. Nakamura, and T. Fujiwara: Isolation and
expression of a cDNA for human brain fatty acid-binding protein (B-FABP). Biochem. Biophy.
Acta, 1354:24-28, 1997
F. Hosoda, Y. Arai, E. Kitamura, J. Inazawa, M. Fukushima, T. Tokino, Y. Nakamura, C. Jones, N.
Kakazu, T. Abe, and M. Ohki: A complete NotI restriction map covering the entire long arm of
human chromosome 11. Genes to Cells, 2:345-357, 1997
Y. Takahashi, H.Fujita, Y. Nakamura, and H. Kurahashi: Dual-color FISH analysis of
Robertsonian translocations. Japanese Journal of Human Genetics, 42:517-523, 1997
Y. Yamane, Y. Nakamura, and M. Isomura: Allelic frequencies of twelve dinucleotide repeat
marker loci on chromosome 13 in normal Japanese population. Japanese Journal of Human
Genetics, 42:533-537, 1997
Y. Takei, S. Sasaki, T. Fujiwara, E. Takahashi, T. Muto and Y. Nakamura: Molecular cloning of a
novel gene similar to myeloid antigen CD33 and its specific expression in placenta. Cytogenetics
Cell Genetics, 78:295-300, 1997
Y. Omori, H. Kyushiki, S. Takeda, M. Suzuki, A. Kawai, T. Fujiwara, E. Takahashi and Y.
Nakamura: Cloning, expression and mapping of a novel human zinc-finger gene TCF17
homologous to rodent Kid1. Cytogenetics Cell Genetics, 78:285-288, 1997
K. Kagawa, T. Inoue, T. Tokino, Y. Nakamura, and T. Akiyama: Overexpression of GML promotes
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radiation-induced cell cycle arrest and apoptosis. Biochemical and Biophysical Research
T.K. Watanabe, M. Suzuki, Y. Omori, H. Hishigaki, M. Horie, N. Kanemoto, T. Fujiwara, Y.
Nakamura, and E. Takahashi: Cloning and characterization of a novel member of the human mad
gene family (MADH6). Genomics, 42:446-451, 1997
T. Shiratsuchi, H. Nishimori, H. Ichise, Y. Nakamura, and T. Tokino: Cloning and characterization
of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).
S. Ishikawa, M. Kai, Y. Murata, M. Tamari, Y. Daigo, T. Murano, M. Ogawa, and Y. Nakamura:
Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.
Journal of Human Genetics, 43:132-134, 1998
H. Nagase and Y. Nakamura: Cleavage using Rnase to detect mutations. Mutation
Detection, :63-80, 1998
M. Itoh, S. Tsukada, T. Orita, J. Nishiu, H. Tomoike, and Y. Nakamura, and T. Tanaka:
Identification by differential display of eight known genes induced during in vivo intimal
hyperplasia. Journal of Human Genetics, 43:9-13, 1998
M. Matsushima, T. Fujiwara, E. Takahashi, T. Minaguchi, Y. Eguchi, Y. Tsujimoto, K. Suzumori, Y.
Nakamura: Isolation and functional analysis of a novel human cDNA (BNIP3L) encoding a protein
homologous to human Nip3. Genes Chromosomes and Cancer, 21:230-235, 1998
T. Katagiri, F. Kasumi, M. Yoshimoto, K. Asaishi, R. Abe, A. Tsuchiya, M. Sugano, T. Nomizu, S.
Takai, M. Yoneda, K. Nanba, M. Makita, H. Okazaki, K. Hirata, M. Okazaki, Y. Furutsuma, Y.
Morishita, Y. Iino, T. Karino, T. Fukutomi, H. Ayabe, S. Hara, T. Kajiwara, S. Houga, T. Shimizu,
M. Toda, Y. Yamasaki, T. Uchida, K. Kunitomo, H.Sonoo, J. Kurebayashi, K. Shimotuma, Y.
Nakamura, and Y. Miki: High proportion of missense mutations of the BRCA1 and BRCA2 genes
in Japanese breast cancer families. Journal of Human Genetics, 43:42-48, 1998
A. Okawa, S. Ikegawa, I. Nakamura, S. Goto, H. Moriya, and Y. Nakamura: Mapping of a gene
responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior
longitudinal ligament of the spine (OPLL). Mammalian Genome, 9:155-156, 1998
K. Ueda, M. Nishijima, H. Inui, M. Watatani, E. Yayoi, J. Okamura, M. Yasutomi, Y. Nakamura,
and Y. Miyoshi: Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers.
Japanese Journal of Cancer Research, 89:17-21, 1998
S. Shirahama, K. Ogura, H. Takami, K. Ito, T. Tohsen, A. Miyauchi, and Y. Nakamura: Mutational
analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma.
K. Ozaki, M. Nagata, M. Suzuki, T. Fujiwara, Y. Miyoshi, O. Ishikawa, H. Ohigashi, S. Imaoka, E.
Takahashi, and Y. Nakamura: Isolation and characterization of a novel human pancreas-specific
gene, "pancpin", that is down-regulated in pancreatic cancer cells. Genes Chromosomes and
Cancer, 22:179-185, 1998
H. Nakagawa, K. Koyama, T. Tanaka, Y. Miyoshi, H. Ando, S. Baba, M. Watatani, M. Yasutomi,
M. Monden, and Y. Nakamura: Localization of the gene responsible for Peutz-Jeghers syndrome
within a 6-cM region of chromosome 19p13.3. Human Genetics, 102:203-206, 1998
J. Nisiu, T. Tanaka, and Y. Nakamura: Isolation and chromosomal mapping of the human
homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential dsplay method.
Genomics, 48:254-257, 1998
K. Mori, K. Iwao, Y. Miyoshi, A. Nakagawara, K. Kofu, T. Akiyama, N. Arita, T. Hayakawa and Y.
Nakamura: Identification of brain-specific splicing variants of the hDLG1 gene and altered splicing
in neuroblastoma cell lines. Journal of Human Genetics, 43:123-127, 1998
T. Itoh, T. Tanaka, R. Nagai, T. Kamiya, T. Sawayama, T. Nakayama, H. Tomoike, H. Sakurada,
Y.Yazaki, and Y. Nakamura: Genomic organization and mutational analysis of HERG, a gene
responsible for familial long QT syndrome. Human Genetics, 102:435-439, 1998
M. Emi, M. Matsushima, T. Katagiri, T. Yokota, T. Nakata, F. Kasumi, Y. Miki, M.H. Skolnick and
Y. Nakamura: Multiplex mutation screening of the BRCA1 gene in 1000 Japanese breast cancers.
A. Iida, K. Kurose, R. Isobe, F. Akiyama, G. Sakamoto, M. Yoshimoto, F. Kasumi, Y. Nakamura,
and M. Emi: Mapping of a new target region of allelic loss to a 2-cM interval at 22q13.1 in primary
breast cancer. Genes Chromosomes and Cancer, 21:108-112, 1998
T. Nakata, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi:
Identification of a new commonly deleted region within a 2-cM interval of 11p11 in breast cancers.
Europian Journal of Cancer, 34:417-421, 1998
K. Tsukamoto, N. Itoh, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M.
Emi: Allelic loss on chromosome 1p is associated with progression and lymph node metastasis
of primary breast carcinoma. Cancer, 82:317-322, 1998
T. Katagiri, H. Saito, A. Shinohara, H. Ogawa, N. Kamada, Y. Nakamura, and Y. Miki: Multiple
possible sites of BRCA2 interacting with DNA repair protein Rad51. Genes Chromosomes and
Cancer, 21:217-222, 1998
K. Iwao, S. Nakamori, M. Kameyama, S. Imaoka, M. Kinoshita, T. Fukui, S. Ishiguro, Y.
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Nakamura, and Y. Miyoshi: Activation of the β-catenin gene by interstitial deletions involving exon
3 in primary colorectal carcinomas without APC mutations. Cancer Research, 58:1021-1026,
1998
S. Yamamoto, M. Okada, M. Tsujikawa, Y. Shimomura, K. Nishida, Y. Inoue, H. Watanabe, N.
Maeda, H. Kurahashi, S. Kinoshita, Y. Nakamura, and Y. Tano: A kerato-epithelin (βig-h3)
mutation in Lattice corneal dystrophy type IIIA. Am. J. Human Genetics, 62:719-722, 1998
N. Kanemoto, H. Hishigaki, A. Miyakita, K. Oga, S. Okuno, A. Tsuji, T. Takagi, E. Takahashi, Y.
Nakamura, and T. K. Watanabe: Genetic dissection of "OLETF", a rat model for non-insulin
dependent diabetes mellitus. Mammalian Genome, 9:419-425, 1998
Y. Takei, S. Ishikawa, T. Tokino, T. Muto and Y. Nakamura: Isolation of a novel tp53 target gene
from a colon cancer cell line carrying a highly regulated wild-type tp53 expression system. Genes
H.-J. Han, T. Tokino and Y. Nakamura: CSR, a scavenger receptor-like protein with a protective
role against cellular damage caused by UV irradiation and oxidative stress. Human Molecular
Genetics, 7:1039-1046, 1998
M. Fujimoto, P.N. Kantaputra, S. Ikegawa, Y. Fukushima, S. Sonta, M. Matsuno, T. Ishida, T.
Matsumoto, S. Kondo, H. Tomita, H.-X. Deng, M. D'urso, M.M. Rinaldi, V. Ventroto, T. Takagi, Y.
Nakamura, and N. Niikawa: The gene for mesomeric dysplasia Kantaputra type is mapped to
chromosome 2q24-q32. Journal of Human Genetics, 43:32-36, 1998
H. Kurahashi, M. Sakamoto, J. Ono, A. Honda, S. Okada, and Y. Nakamura: Molecular cloning of
the chromosomal breakpoint in the LIS1 gene of a patient with isolated lissencephaly and
balanced t(8;17). Human Genetics, 103:189-192, 1998
T. Aihara, Y. Miyoshi, K. Koyama, M. Suzuki, E. Takahashi, M. Monden, and Y. Nakamura:
Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of drosophila
ISWI. Cytogenetics Cell Genetics, 81:191-193, 1998
Y. Yamane, K. Kogawa, T. Tanaka, Y. Nakamura, and M. Isomura: Heterozygosities and allelic
frequencies of 358 dinucleotide-repeat marker loci in the Japanese population. Journal of Human
Genetics, 43:165-168, 1998
S. Saito, M. Matsushima, S. Sirahama, T. Minaguchi, Y. Kanamori, M. Minami and Y. Nakamura:
Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6
Gene. DNA Research, 5:115-120, 1998
T. Shiratsuchi, M. Futamura, K. Oda, H. Nishimori, Y. Nakamura, and T. Tokino: Cloning and
characterization of BAP1 (BAI-associated protein 1): a PDZ domain-containing protein that
interacts with BAI1. Biochemical and Biophysical Research Communications, 247:597-604, 1998
H. Nakagawa, K. Koyama, Y. Miyoshi, H. Ando, S. Baba, M. Watatani, M. Yasutomi, N. Matsuura,
M. Monden, and Y. Nakamura: Nine novel germline mutations of STK11 in ten families with
Peutz-Jeghers syndrome. Human Genetics, 103:168-172, 1998
T. Itoh, T. Tanaka, R. Nagai, K, Kikuchi, S. Ogawa, S. Okada, S. Yamagata, K. Yano, Y. Yazaki,
and Y. Nakamura: Genomic organization and mutational analysis of KVLQT1, a gene responsible
for familial long QT syndrome. Human Genetics, 103:290-294, 1998
Y. Miyoshi, K. Iwao, Y. Nagasawa, T. Aihara, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, and
Y. Nakamura: Activation of the beta-catenin gene in primary hepatocellular carcinomas by
somatic alterations involving exon 3. Cancer Research, 58:2524-2527, 1998
H.-J. Han, and Y. Nakamura: Dinucleotide repeat polymorphism in the first intron of the CSR
gene. Journal of Human Genetics, 43:212-213, 1998
Y. Nakamura, K. Koyama, and M. Matsushima: VNTR (variable number of tandem repeat)
sequences as transcriptional, translational, or functional regulators. Journal of Human Genetics,
43:149-152, 1998
S. Matsuura, H. Tauchi, A. Nakamura, N. Kondo, S. Sakamoto, D. Smeets, C. Weemaes, B.H.
Belohradsky, M Oshimura, M Isomura, Y. Nakamura and K. Komatsu: Positional cloning of the
gene for Nijimegen breakage syndrome. Nature Genetics, 19:179-181, 1998
K. Bando, S. Matsumoto, M. Onda, F. Akiyama, G. Sakamoto, M. Yoshimoto, F. Kasumi, Y.
Nakamura, and M. Emi: Frequent allelic loss at 6q26-27 in breast carcinomas of the solid-tubular
histologic type. Breast Cancer, 5:127-130, 1998
T. Aihara, S. Noguchi, Y. Miyoshi, H. Nakano, Y. Sasaki, Y. Nakamura, and S. Imaoka: Allelic
imbalance of insulin-like growth factor II gene expression in cancerous and precancerous lesions
of the liver. Hepatology, 28:86-89, 1998
O. Maruyama, H. Nishimori, T. Katagiri, Y. Miki, A. Ueno, and Y. Nakamura: Cloning of TCFL5
encoding a novel human basic helix-loop-helix motif protein that is specifically expressed in
primary spermatocytes at the pachytene stage. Cytogenetics Cell Genetics, 82:41-45, 1998
A. Okawa, I. Nakamura, S. Goto, H. Moriya, Y. Nakamura, and S. Ikegawa: Mutation in Npps in a
mouse model of ossification of the posterior longitudinal ligament of the spine. Nature Genetics,
19:271-273, 1998
M.Tamari, Y. Daigo, S, Ishikawa, and Y. Nakamura: Genomic structure of a novel human gene
(XYLB) on chromosome 3p22 --> p21.3 encoding a xylulokinase-like protein. Cytogenetics Cell
Genetics, 82:101-104, 1998
459. T. Nakajima, T. Furukawa, T. Tanaka, Y. Katayama, R. Nagai, Y. Nakamura, and M. Hiraoka:
Novel mechanism of HERG current suppression in LQT2: shift in voltage dependent of HERG
inactivation. Circulation Research, 83:415-422, 1998
460. K. Ohgaki, A. Iida, F. Kasumi, G. Sakamoto, M. Akimoto, Y. Nakamura, and M. Emi: Mapping of a
new target region of allelic loss to a 6-cM interval at 21q21 in primary breast cancers. Genes
461. K. Kobayashi, Y. Nakahori, K. Mizuno, M. Miyake, Y. Nakamura, K. Tokunaga and T. Toda:
Founder-haplotype analysis in Fukuyama-type congenital muscular dystrophy (FCMD). Human
Genetics, 103:323-327, 1998
462. T. Fujiwara, A. Saito, M. Suzuki, H. Shinomiya, T. Suzuki, E. Takahashi, A. Tanigami, A. Ichiyama,
C. H. Chung, Y. Nakamura, and K. Tanaka: Identification and cromosomal assignment of USP1,
a novel gene encoding a human ubiquitin-specific protease. Genomics, 54:155-158, 1998
463. K. Kurose, A. Iida, T. Araki, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi: Frequent alleleic
loss at 7p14-15 associated with aggressive histologic types of breast cancer. Japanese Journal of
464. K. Lu, H. Nishimori, Y. Nakamura, K. Shima, M. Kuwajima: A missense mutation of mouse
OCTN2, a sodium-dependent carnitine cotransporter, is juvenile visceral steatosis (JVS) mouse.
465. K. Kobayashi, Y. Nakahori, M. Miyake, Y. Nomura, M. Yoshioka, K. Saito, M. Osawa, J. Goto, Y.
Nakagome, I. Kanazawa, Y. Nakamura, K. Tokunaga, and T. Toda: An ancient retrotransposal
insertion causes Fukuyama-type congenital muscular dystrophy (FCMD). Nature, 394:388-392,
1998
466. K. Ozaki, T. Fujiwara, Y. Nakamura, and E. Takahashi: Isolation and mapping of a novel human
kidney - and liver- specific gene homologous to the bacterial acetyltransferase. Journal of Human
Genetics, 43:255-258, 1998
467. S. Okamoto, M. Matsushima and Y. Nakamura: Identification, genomic organization, and
alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein. Cytogenetics
Cell Genetics, 83:25-29, 1998
468. J. Nishiu, T. Tanaka, and Y. Nakamura: Identification of a novel gene (ECM2) encoding a putative
extracellular matrix protein expressed predominantly in adipose and female-specific tissues and
its chromosomal localization to 9q2.3. Genomics, 52:378-381, 1998
469. K. Ozaki, M. Nagata, M. Suzuki, T. Fujiwara, K. Ueda, Y. Miyoshi, E. Takahashi, and Y.
Nakamura: Isolation and characterization of a novel human lung-specific gene homologous to
lysosomal membrane glycoproteins 1 and 2; significantly increased expression in cancers of
various tissues. Cancer Research, 58:3499-3503, 1998
470. Y. Ohmori, M. Suzuki, K. Ozaki, Y. Harada, Y. Nakamura, E. Takahashi, and T. Fujiwara:
Expression and chromosomal localization of KIAA0369, a putative kinase structually related to
Doublecortin. Journal of Human Genetics, 43:169-177, 1998
471. Y. Ariyama, Y. Fukuda, Y. Okuno, M. Seto, K. Date, T. Abe, Y. Nakamura, and J. Inazawa:
Amplification on double-minute chromosome and partial-tandem duplication of the MLL gene in
leukemic cells of a patient with acute myelogenous leukemia. Genes Chromosomes and Cancer,
23:267-272, 1998
472. T. Nishiwaki, Y. Daigo, M. Tamari, Y.Fujii, and Y. Nakamura: Molecular cloning, mapping, and
characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to
organic-cation transporters. Cytogenetics Cell Genetics, 83:251-255, 1998
473. M. Sakamoto, J. Ono, S. Okada, M. Masuno, Y. Nakamura, and H. Kurahashi: Alteration of the
LIS1 gene in Japanese patients with isolated lissencephaly sequence or Miller-Dieker syndrome.
Human Genetics, 103:586-589, 1998
474. M. Tsujikawa, H. Kurahashi, T. Tanaka, M. Okada, S. Yamamoto, N. Maeda, H. Watanabe, Y.
Inoue, A. Kiridoshi, K. Matsumoto, Y. Ohishi, S. Kinishita, Y. Shimomura, Y. Nakamura, and Y.
Tano: Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy
(GDLD) to chromosome 1p. Am. J. Human Genetics, 63:1073-1077, 1998
475. T. Minaguchi, Y. Kanamori, M. Matsushima, H. Yoshikawa, Y. Taketani, and Y. Nakamura: No
evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in
Japanese patients with HPV16/18 infection. Cancer Research, 58:4585-4586, 1998
476. S. Ikegawa, H. Ohashi, K. C. Kim, A. Sannohe, G. Nishimura, M. Kimizuka, Y. Fukushima, T.
Nagai, Y. Nakamura: Novel and recurrent COMP (cartilage oligomeric matrix protein) mutations in
pseudoachondroplasia and multiple epiphyseal dysplasia. Human Genetics, 103:633-638, 1998
477. H. Nakagawa, Y. Murata, K. Koyama, A. Fujiyama, Y. Miyoshi, M. Monden, T. Akiyama, and Y.
Nakamura: Identification of a brain-specific APC homologue, APCL, and its interaction with
β-catenin. Cancer Research, 58:5176-5181, 1998
478. Y. Nakamura, J. Inazawa: Genetic diagnosis of cancer. (review) International Journal of Clinical
Oncology, 3:265-270, 1998
479. Y. Nakamura:, ATM: the p53 booster. Nature Medicine, 4:231-1232, 1998
480. T. Shiratsuchi, K. Oda, H. Nishimori, M. Suzuki, E. Takahashi, T. Tokino, and Y. Nakamura:
Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein
481.
482.
483.
484.
485.
486.
487.
488.
489.
490.
491.
492.
493.
494.
495.
496.
497.
498.
499.
500.
that interacts with BAI1. Biochemical and Biophysical Research Communications, 251:158-165,
1998
Y. Miyoshi, K. Iwao, G. Nawa, H.Yoshikawa, T. Ochi, and Y. Nakamura: Frequent mutations in
the -catenin gene in desmoid tumors from patients without familial adenomatous polyposis.
Oncology Research, 10:591-594, 1998
S. Ikegawa, G. Nishimura, T. Nagai, T. Hasegawa, H. Ohashi, Y. Nakamura: Mutation of the type
X collagen gene (COL10A1) causes spondylometaphyseal dysplasia. Am. J. Human Genetics,
63:1659-1662, 1998
G. Nawa, T. Urano, T. Tokino, T. Ochi, Y. Miyoshi: Cloning and characterization of the murine
P2XM receptor gene. Journal of Human Genetics, 43:262-267, 1998
K. Oda, T. Shiratsuchi, H. Nishimori, J. Inazawa, H. Yoshikawa, Y. Taketani, Y. Nakamura, T.
Tokino: Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of
hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. Cytogenetics
Cell Genetics, 84:75-82, 1999
H. Tauchi, S. Matsuura, M. Isomura, T. Kinjo, A. Nakamura, S. Sakamoto, N. Kondo, S. Endo, K.
Komatsu, and Y. Nakamura: Sequence analysis of an 800-kb genomic DNA region on
chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. Genomics,
55:242-247, 1999
T. Yokota, M. Yoshimoto, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi:
Localization of a tumor suppressor gene associated with progression of human breast cancer
within a 1-cM interval of 8p22-p23.1. Cancer, 85:447-452, 1999
T. Katagiri, M. Futamura, and Y. Nakamura: A Gln/Arg polymorphism at codon 349 of the
hBUBR1 gene. Journal of Human Genetics, 44:131-132, 1999
K. Iwao, Y. Miyoshi, G. Nawa, H. Yoshikawa, T. Ochi, and Y. Nakamura: Frequent beta-catenin
abnormalities in bone and soft-tissue tumors. Japanese Journal of Cancer Research, 90:205-209,
1999
K. Kyo, M. Parkes, Y. Takei, H. Nishimori, H. Nagawa, S. Baba, T. Muto, G. M. Lathrop, Y.
Nakamura: Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin
gene, MUC3. Human Molecular Genetics, 8:307-311, 1999
I. Smith, M.A. Narang, T. Evans, C. Heimann, Y. Nakamura, G. Chenevix-Trech, T. Pietsvh, C.
Wicking, and B.J. Wainwright: Isolation and characterization of human Patched 2 (PTCH2), a
putative tumor suppressor gene in basal cell carcinoma and medulloblastoma on chromosome
1p32. Human Molecular Genetics, 8:291-297, 1999
M. Tamari, Y. Daigo, and Y. Nakamura: Isolation and characterization of a novel serine threonine
kinase gene on chromosome 3p22-21.3. Journal of Human Genetics, 44:116-120, 1999
G. Nawa, Y. Miyoshi, H. Yoshikawa, T. Ochi, and Y. Nakamura: Frequent loss of expression or
aberrant alternative splicing of P2XM, a p53-inducible gene, in soft-tissue tumors. British Journal
of Cancer, 80:1185-1189, 1999
T. Watanabe, M.-T. Bihoreau, L. C. McCarthy, S. L. Kiguwa, H. Hishigaki, A. Tsuji, J. Browne,
Y.Yamasaki, A, Mizoguchi-Miyakita, K. Oga, T. Ono, S. Okuno, N. Kanemoto, E. Takahashi, H.
Hayashi, M. Adachi, C. Webber, M. Davis, S.Kiel, C. Knights, A. Smith, R. Critcher, J. R. Hudson,
Jr., T. Day, Y. Irie, T. Takagi, Y. Nakamura, P. N. Goodfellow, G. M. Lathrop, A. Tanigami, and
M. R. James: A radiation hybrid map of the rat genome containing 5,255 markers. Nature
Genetics, 22:27-36, 1999
I. Nakamura, A. Okawa, S. Ikegawa, K. Takaoka and Y. Nakamura: Genomic organization,
mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein
(CILP). Journal of Human Genetics, 44:203-205, 1999
Y. Daigo, M. Isomura, T. Nishiwaki, M. Tamari, S. Ishikawa, M. Kai, Y. Murata, K. Takeuchi, Y.
Yamane, R. Hayashi, M. Minami, M. A. Fujino, Y. Hojo, I. Uchiyama, T. Takagi, and Y. Nakamura:
Characterization of a 1,200-kb genomic segment of chromosome 3p22-p21.3. DNA Research,
6:37-44, 1999
T. Imazu, S. Shimizu, S. Tagami, M. Matsushima, Y. Nakamura, T. Miki, A. Okuyama, and Y.
Tsujimoto: Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-XL
and induces apoptosis by altering mitochondrial membrane permiability. Oncogene,
18:4523-4529, 1999
O. Watanabe, K. Natori, M. Tamari, Y.Shiomoto, S.Kubo, and Y. Nakamura: Significantly
elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic
dermatitis. Journal of Human Genetics, 45:173-176, 1999
S. Ikegawa, M. Isomura, Y. Koshizuka and Y. Nakamura: Cloning and characterization of ASH2L
and Ash21, human and mouse homologs of the Drosophila ash2 gene. Cytogenetics Cell
Genetics, 84:167-172, 1999
M. Futamura, H. Nishimori, T. Shiratsuchi, S. Saji, Y. Nakamura, T. Tokino: Molecular cloning,
mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a
metastasis-associated gene, MTA1. Journal of Human Genetics, 44:52-56, 1999
M. Tsujikawa, H. Kurahashi, T. Tanaka, K. Nishida, Y. Shimomura, Y. Tano, and Y. Nakamura:
Identification of the gene responsible for gelatinous drop-like corneal dystrophy. Nature Genetics,
21:420-423, 1999
501. Y. Daigo, T. Nishiwaki, T. Kawasoe, M. Tamari, E. Tsuchiya, and Y. Nakamura: Molecular cloning
of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. Cancer Research,
59:1966-1972, 1999
502. T. Nishiwaki, Y. Daigo, T. Kawasoe, Y. Nagasawa, H. Ishiguro, M. Fujita, Y. Furukawa and Y.
Nakamura: Isolation and characterization of a human cDNA homologous to the Xenopus laevis
XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family. Journal of
503. T. Sakabe, T. Shinomiya, T. Mori, Y. Ariyama, Y. Fukuda, T. Fujiwara, Y. Nakamura, and J.
Inazawa: Identification of a novel gene, MASL1, within an amplicon at 8p23.1 detected in
malignant fibrous histiocytomas by comparative genomic hybridization. Cancer Research,
59:511-515, 1999
504. C. Sakakura, T. Mori, T. Sakabe, Y. Ariyama, T. Shinomiya, K. Date, A. Hagiwara, T. Yamaguchi,
T. Takahashi, Y. Nakamura, T. Abe, and J. Inazawa: Gains, losses, and amplification of genomic
materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes
505. T. Shinomiya, T. Mori, Y. Ariyama, T. Sakabe, Y. Fukuda, Y. Murakami, Y. Nakamura, and J.
Inazawa: Comparative genomic hybridization of squamous cell carcinomas of the esophagus: the
possible involvement of the DPI gene in the 13q34 amplicon.
Genes Chromosomes and
Cancer, 24:337-344, 1999
506. K. Fukino, A. Iida, A. Teramoto, G. Sakamoto, F. Kasumi, Y. Nakamura and M. Emi: Frequent
allelic loss at the TOC locus on 17q25.1 in promary breast cancers.
Genes Chromosomes and
Cancer, 24:345-350, 1999
507. T. Minaguchi, M. Matsushima, S. Saito, Y. Kanamori, S. Shirahama, S. Okamoto, M. Minami, Y.
Taketani, and Y. Nakamura: Complete DNA sequence and characterization of a 330-kb
VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer. DNA
Research, 6:131-136, 1999
508. T. Mori, Y. Fukuda, H. Kuroda, T. Matsumura, S. Ota, T. Sugimoto, Y. Nakamura, and J. Inazawa:
Cloning and characterization of a novel rab-family gene, Rab36, within the region at 22q11.2 that
is homozygously deleted in malignant rhabdois tumors. Biochemical and Biophysical Research
509. H. Nakagawa, K. Koyama, S. Nakamori, M. Kameyama, S. Imaoka, M. Monden, Y. Nakamura:
Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite
instability. Japanese Journal of Cancer Research, 90:633-637, 1999
510. M. Emi, M. Yoshimoto, T. Sato, S. Matsumoto, T. Iwase, I. Ito, K. Minobe, T. Tada, T. Katagiri, K.
Bando, F. Akiyama, Y. Harada, K. Fukino, G. Sakamoto, M. Matsushima, A. Iida, H. Saito, F.
Kasumi and Y. Nakamura: Allelic losses at 1p34, 13q12, 17p13.3 and 17q21.1 correlates with
poor postoperative prognosis in breast cancer. Genes Chromosomes and Cancer, 26:134-141,
1999
511. K. Ueda, Y. Miyoshi, T. Tokino, M. Watatani, and Y. Nakamura: Induction of apoptosis in T98G
glioblastoma cells by transfection of GML, a p53-target gene. Oncology Research, 11:125-132,
1999
512. S. Ikegawa, M. Masuno, Y. Kumano, A. Okawa, M. Isomura, K. Koyama, K. Okui, K. Imaizumi,
and Y. Nakamura: Cloning of translocation breakpoints associated with Shwachman syndrome
and identification of a candidate gene. Clinical Genet., 55:466-472, 1999
513. I. Nakamura, S. Ikegawa, A. Okawa, S. Okuda, Y. Koshizuka, H. Kawaguchi, K. Nakamura, T.
Koyama, S. Goto, J. Toguchida, M. Matsushita, T. Ochi, K.Takaoka, and Y. Nakamura:
Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the
spine (OPLL). Human Genetics, 104:492-497, 1999
514. S. Ikegawa, M. Isomura, Y. Koshizuka, and Y. Nakamura: Cloning and characterization of a novel
gene (C8orf2), a human representative of a novel gene family with homology to C. elegans
C42.C1.9. Cytogenetics Cell Genetics, 85:227-231, 1999
515. Y. Nagasawa, Y, Miyoshi, K, Iwao, Y. Shinomura, Y. Matsuzawa, and Y. Nakamura:
Transformation and morphological changes of murine L cells by transfection with a mutated form
of β-catenin. Cancer Research, 59:3539-3542, 1999
516. Y. Onouchi, H. Kurahashi, H. Tajiri, S. Ida, S. Okada, and Y. Nakamura: Genetic alterations in the
JAG1 gene in Japanese patients with Alagille syndrome. Journal of Human Genetics, 44:235-239,
1999
517. M. Ui, M. Takada, T. Arai, K. Matsumoto, K. Yamada, T. Nakahata, T. Nishiwaki, Y. Furukawa, T.
Tokino, Y. Nakamura, and H. Iba: Retrovirus vectors designed for efficient transduction of
cytotoxic or cytostatic genes. Gene Therapy, 6:1670-1678, 1999
518. S. Ikegawa, M. Isomura, Y. Koshizuka, and Y. Nakamura: Cloning and characterization of
human and mouse PROSC (proline synthetase co-transcribed) genes. Journal of Human
Genetics, 44:337-342, 1999
519. C.-C. Ng, K. Koyama, S. Okamura, H. Kondoh, Y. Takei, and Y. Nakamura: Isolation and
characterization of a novel p53-inducible gene, TP53TG3. Genes Chromosomes and Cancer,
26:329-335, 1999
520. Y. Daigo, Y. Furukawa, T. Kawasoe, M. Fujita, H. Ishiguro, S. Sugai, S. Nakamori and Y.
Nakamura: Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced
colorectal cancers from Japanese patients. Cancer Research, 59:4222-4224, 1999
521. M. Nishizaki, T. Fujiwara, T. Tanida, A. Hizuta, H. Nishimori, T. Tokino, Y. Nakamura, M. Bouvet,
J.A. Roth, and N. Tanaka: Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a
proposed mechanism for bystander effect. Clinical Cancer Research, 5:1015-1023, 1999
522. H. Nakagawa, K. Koyama, M. Monden, and Y. Nakamura: Analysis of APCL, a brain-specific APC
homologue, for mutations and expression in brain tumors. Japanese Journal of Cancer Research,
90:982-986, 1999
523. Y. Kanamori, M. Matsushima, T. Minaguchi, K. Kobayashi, S. Sagae, R. Kudo, N. Terakawa, and
Y. Nakamura: Correlation between expression of the matrix metalloprotease-1 (MMP-1) gene in
ovarian cancers and an insertion/deletion polymorphism in its promoter region. Cancer Research,
59:4225-4227, 1999
524. Y. Daigo, M. Isomura, T. Nishiwaki, K. Suzuki, O. Maruyama, K. Takeuchi, Y. Yamane, R.
Hayashi, M. Minami, Y. Hojo, I. Uchiyama, T.Takagi, and Y. Nakamura: Significant differences in
the frequency of transcriptional units, types and numbers of repetitive elements, GC content, and
the number of CpG islands between a 1,010-kb G-band genomic segment on chromosome
9q31.3 and a 1,200-kb R-band genomic segment on chromosome 3p21.3. DNA Research,
6:227-233, 1999
525. T. Tanaka, and Y. Nakamura: Mutational analysis of familial long QT syndrome in Japan.
Potassium Ion Channels, 46:103-116, 1999
526. T. Minaguchi, T. Mori, Y. Kanamori, M. Matsushima, H. Yoshikawa, Y. Taketani, and Y.
Nakamura: Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer
of the PTEN gene. Cancer Research, 59:6063-6067, 1999
527. T. Yokota, M. Yoshimoto, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura, M. Emi: Frequent
multiplication of chromosomal region 8q24.1 associated with aggressive histologic types of breast
cancers. Cancer Letters, 139:7-13, 1999
528. C. Sakakura, A. Hagiwara, H. Taniguchi, T. Yamaguchi, H. Yamagishi, K.Koyama, Y. Nakamura,
T. Abe, and J. Inazawa: Chromosomal aberations in human hepatocellular carcinomas
associated with hepatitis C virus infection detected by comparative genomic hybridization. British
Journal of Cancer, 80:2034-2039, 1999
529. T. Nakajima, T. Furukawa, Y. Hirano, T. Tanaka, H. Sakurada,T. Takahashi, R. Nagai, T. Itoh, Y.
Katayama, Y. Nakamura, and M. Hiraoka: Voltage-shift of the current activation in HERG S4
mutation (R534C) in LQT2. Cardiovascular Research, 44:283-293, 1999
530. E. Kondo-Iida, K. Kobayashi, M. Watanabe, J. Sasaki, T. Kumagai, H. Koide, K. Saito, M. Ozawa,
Y. Nakamura, and T. Toda: Novel mutations and genotyoe-phenotype relationships in 107
families with Fukuyama-type congenital muscular dystrophy (FCMD). Human Molecular Genetics,
8:2303-2309, 1999
531. K. Natori, M. Tamari, O. Watanabe, Y. Onouchi, Y. Shiomoto, S. Kubo and Y. Nakamura:
Mapping of a gene responsible for dermatitis of NOA (Naruto Research Institute Otsuka Atrichia)
mice, an animal model of allergic dermatitis. Journal of Human Genetics, 44:372-376, 1999
532. M. Nishihara, M. Terada, J. Kamogawa, Y. Ohashi, S. Mori, S. Nakatsuru, Y. Nakamura, and M.
Nose: Genetic basis of autoimmune siladenitis in MRL/lpr lupus-prone mice. Arthritis &
Rheumatism, 42:2616-2623, 1999
533. M. Isomura, S. Ikegawa, T. Kinjo, K. Takeuchi, Y. Yamane-Tanaka, K. Kitami, and Y. Nakamura:
Sequence analysis of a total of three megabases of DNA in two regions of chromosome 8p. DNA
Research, 6:387-400, 1999
534. M. Suzuki, T. Watanabe, T. Fujiwara, Y. Nakamura, E. Takahashi, and A. Tanigami: Molecular
cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human
gadd45 and murine MyD118. Journal of Human Genetics, 44:300-303, 1999
535. A. Saito, K. Ozaki, T. Fujiwara, Y. Nakamura, and A. Tanigami: Isolation and mapping of a human
lung-specific gene, TSA1902, encoding a novel chitinase family member. Gene, 239:325-331,
1999
536. S. Nakatsuru, M. Terada, M. Nishihara, J. Kamogawa, T. Miyazaki, W.-M. Qu, K. Morimoto, C.
Yazawa, H. Ogasawara, Y. Abe, K. Fukui, G. Ichien, M. Ito, S. Mori, Y. Nakamura, and M. Nose:
Genetics dissection of the complex pathological manifestations of collagen disease in MRL/lpr
mice. Pathology International, 49:974-982, 1999
537. K. Minobe, K. Bando, K. Fukino, S. Soma, F. Kasumi, G. Sakamoto, K. Furukawa, K. Higuchi, M.
Onda, Y. Nakamura, and M. Emi: Somatic mutation of the PTEN/MMAC1 gene in breast cancers
with microsatellite instability. Cancer Letters, 144:9-16, 1999
538. K. Tsukamoto, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi:
Frequent multiplication of chromosome 1q in non-invasive and papillotubular carcinoma of the
breast. Cancer Letters, 141:21-28, 1999
539. M. Emi, Y. Utada, M. Yoshimoto, T. Sato, S. Matsumoto, T. Iwase, I. Ito, K. Minobe, T. Tada, T.
Katagiri, K. Bando, F. Akiyama, Y. Harada, K. Fukino, G. Sakamoto, M. Matsushima, A. Iida, H.
540.
541.
542.
543.
544.
545.
546.
547.
548.
549.
550.
551.
552.
553.
554.
555.
556.
557.
558.
559.
Saito, F. Kasumi and Y. Nakamura: Correlation of allelic loss with poor postoperative survival in
breast cancer. Breast Cancer, 6:351-356, 1999
S. Kunishima, T. Kojima, T. Tanaka, T. Kamiya, K. Ozawa, Y. Nakamura, and H. Saito: mapping
of a gene for May-Hegglin anomaly to chromosome 22q. Human Genetics, 105:379-383, 1999
S. Okamura, C. Ng Ching, K. Koyama, Y. Takei, M. Monden, and Y. Nakamura: Identification of
seven genes regulated by wild-type p53 in a colon-cancer cell line carrying a well-controled
wild-type p53 expression system. Oncology Research, 11:281-285, 1999
T. Mori, H. Arakawa, T. Tokino, K. Mineura, and Y. Nakamura: Significant increase of adenovirus
infectivity in glioma cell lines by extracellular domain of hCAR. Oncology Research, 11:513-521,
1999
H. Tomita, S. Nagamitsu, K. Wakui, Y. Fukushoma, K. Yamada, M. Sadamatsu, A. Masui, T.
Konishi, T. Matsuishi, M. Aihara, K. Shimizu, K. Hashimoto, H. Mineta, M. Matsushima, T. Tsujita,
M. Saito, H. Tanaka, S. Tsuji, T. Takagi, Y. Nakamura, S. Nanko, N. Kato, Y. Nakane, and N.
Niikawa: Paroximal kinesigenic choreoathetosis locus maps to chromosome 16p11.2-q12.1. Am.
J. Human Genetics, 65:1688-1697, 1999
S. Okuno, T.K. Watanabe, T. Ono, Y. Yamasaki, Y. Goto, H. Miyao, T. Asai, N. Kanemoto, K.
Ogawa, A. Mizoguchi-Miyatake, T. Takagi, E. Takahashi, Y. Nakamura, and A. Tanigami: Genetic
determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats. Genomics,
62:350-355, 1999
T.K. Watanabe, S. Okuno, K. Oga, A. Mizoguchi-Miyakita, A. Tsuji, Y. Yamasaki, H. Hishigaki, N.
Kanemoto, T. Takagi, E. Takahashi, Y. Irie, Y. Nakamura, A. Tanigami: Genetic dissection of
"OLETF," a rat model for non-insulin-dependent diabetes mellitus: Quantitative trait locus
analysis of (OLETF x BN) x OLETF. Genomics, 58:233-239, 1999
N. Ide, Y. Hata, H. Nishioka, K. Hirao, I. Yao, M. Deguchi, A. Mizoguchi, H. Nishimori, T. Tokino,
Y. Nakamura, and Y. Takai: Localization of membrane-associated guanylate kinase
(MAGI)-1/BAI-associated protein (BAP) 1 at tight junctions of epithelial cells. Oncogene,
18:7810-7815, 1999
Y. Harada, K. Ozaki, M. Suzuki, T. Fujiwara, E. Takahashi, Y. Nakamura, A. Tanigami: Complete
cDNA sequence and genomic organization of a human pancreas-specific gene homologous to
Caenorhabditis elegans sel-1. Journal of Human Genetics, 44:330-336, 1999
Y. Ariyama, T. Mori, T. Shinomiya, T. Sakabe, Y. Fukuda, A. Kanamaru, Y. Yamada, M. Isobe, M.
Seto, Y. Nakamura, J. Inazawa: Chromosomal imbalances in adult T-cell leukemia revealed by
comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines. Journal of Human
Genetics, 44:357-363, 1999
Y. Utada, S. Haga, T. Kajiwara, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi:
Allelic loss at the 8p22 region as a prognostic factor in large and estrogen receptor negative
breast carcinomas. Cancer, 88:1410-1416, 2000
Y. Utada, S. Haga, T. Kajiwara, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi:
Mapping of target regions of allelic loss in primary breast cancers to 1-cM intervals on genomic
contigs at 6q21 and 6q25.3. Japanese Journal of Cancer Research, 91:293-300, 2000
S. Isaka, Y. Takei, T. Tokino, Y. Miyoshi, K. Koyama, M. Suzuki, E. Takahashi, C. Azuma, Y.
Murata, and Y. Nakamura: Isolation and characterization of a nobel TP53-inducible gene,
TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression.
T. Tokino and Y. Nakamura: The role of p53-target genes in human cancer. Crinical reviews in
Oncology/Hematology, 33:1-6, 2000
H. Nakagawa, K. Koyama, Y. Murata, M. Morito, T. Akiyama,and Y. Nakamura: EB3, a novel
member of the EB1 family preferentially expressed in the central nervous system, binds to a
CNS-specific APC homologue. Oncogene, 19:210-216, 2000
T. Nishiwaki, Y. Daigo, T. Kawasoe, and Y. Nakamura: Isolation and mutational analysis of a
novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor
locus in 9q32. Genes Chromosomes and Cancer, 27:169-176, 2000
H. Akashi, H.-J. Han, M. Iizaka, Y. Nakajima, S. Sugano, K. Imai and Y. Nakamura: Isolation and
characterization of a human cDNA encoding a protein homologous to the 7.2-kDa protein
(subunit X) of bovine ubiquinol-cytochrome C reductase. Journal of Human Genetics, 45:43-46,
2000
H. Nakagawa, K. Koyama, Y. Murata, M. Morito, T. Akiyama, Y. Nakamura: APCL, a
CNS-specific homologue of APC, Binds to p53-Binding protein 2 and translocates it to the
perinucleus. Cancer Research, 60:101-105, 2000
T. Kinjo, M. Isomura, T. Iwamasa, and Y. Nakamura: Molecular cloning and characterization of
two novel genes on chromosome 8p21.3. Journal of Human Genetics, 45:12-17, 2000
M. Iizaka, H.-J. Han, H. Akashi, Y. Nakajima, S. Sugano, M. Ogawa, and Y. Nakamura: Isolation
and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like
actin-binding proteins. Cytogenetics Cell Genetics, 88:221-224, 2000
C. Kihara, T. Seki, Y. Furukawa, H. Yamana, Y. Kimura, P. van Schaardenburgh, K. Hirata, and Y.
Nakamura: Mutations in zinc-binding domains of p53 as a prognostic marker of
esophageal-cancer patients. Japanese Journal of Cancer Research, 91:190-198, 2000
560. H. Akashi, H.-J. Han, M. Iizaka, Y. Nakajima, Y. Furukawa, S. Sugano, K. Imai and Y. Nakamura:
Isolation and characterization of a novel gene encoding a putative seven-span transmembrane
protein, TM7SF3. Cytogenetics Cell Genetics, 88:305-309, 2000
561. T. Oyama, Y. Miyoshi, K. Koyama, H. Nakagawa, T. Yamori, T. Ito, H. Matsuda and Y. Nakamura:
Isolation of a novel gene on human chromosome 8p21.3-p22 whose expression is reduced
significantly in human colorectal cancers with liver metastasis. Genes Chromosomes and Cancer,
29:9-15, 2000
562. S. Satoh, Y. Daigo, Y. Furukawa, T. Katoh, N. Miwa, T. Nishiwaki, T. Kawasoe, H. Ishiguro, M.
Fujita, T. Tokino, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, Y. Yamaoka, and Y. Nakamura:
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by
virus-mediated transfer of AXIN1. Nature Genetics, 24:245-250, 2000
563. R. Yamada, T. Tanaka, Y. Ohnishi, K. Suematsu, M. Minami, T. Seki, S. Tohma, K. Yamamoto, Y.
Nakamura: Identification of 142 single nucleotide polymorphisms in 41 candidate genes for
rheumatoid arthritis in the Japanese population. Human Genetics, 106:293-297, 2000
564. Y. Ohnishi, T. Tanaka , R. Yamada , K. Suematsu, M. Minami, K. Fujii , N. Hoki , K. Kodama , S.
Nagata , T. Hayashi , N. Kinoshita , H Sato, H. Sato, T. Kuzuya, H. Takeda, M. Hori, and Y.
Nakamura: Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate
genes for ischemic heart disease in the Japanese population. Human Genetics, 106:288-292,
2000
565. M. Futamura, H. Arakawa, K. Matsuda, T. Katagiri, S. Saji, Y. Miki and Y. Nakamura: Potential
role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1. Cancer Research,
60:1531-1535, 2000
566. H. Iwasa, T. Itoh, R. Nagai, Y. Nakamura, and T. Tanaka: Twenty single nucleotide
polymorphisms (SNPs) and their alleleic frequencies in four genes that are responsible for familial
long QT syndrome in the Japanese population. Journal of Human Genetics, 45:182-183, 2000
567. M. Unoki, S. Furuta, Y. Onouchi, O. Watanabe, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, M.
Tamari and Y. Nakamura: Association studies of 33 single nucleotide polymorphisms (SNPs) in
29 candidate genes for bronchial asthma: Positive association of a T924C polymorphism in the
thromboxane A2 receptor gene. Human Genetics, 106:440-446, 2000
568. Z.-Q. Yang, M.A. Yoshida, Y. Fukuda, N. Kurihara, Y. Nakamura, and J. Inazawa: Molecular
cytogenetic analysis of 17 renal cancer cell lines: Increased copy number at 5q31-33 in cell lines
from nonpapillary carcinomas. Japanese Journal of Cancer Research, 91:156-163, 2000
569. H. Tanaka, H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, K. Matsui, Y. Takei, and Y.
Nakamura: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint
DNA damage. Nature, 404:42-49, 2000
570. H. Ishiguro, Y. Furukawa, Y. Daigo, Y. Miyoshi, Y. Nagasawa, T. Nishiwaki, T. Kawasoe, M. Fujita,
S. Satoh,１ N. Miwa, Y. Fujii, and Y. Nakamura: Isolation and characterization of human NBL4, a
gene involved in the β-catenin/Tcf signaling pathway. Japanese Journal of Cancer Research,
91:597-603, 2000
571. Y.-M. Lin, T. kato, S. Satoh, Y. Nakamura and Y. Furukawa: Identification of novel polymorphisms
in the AXIN1 and CDX-2 genes. Journal of Human Genetics, 45:254-256, 2000
572. K. Shiraishi, S. Fukuda, T. Mori, K. Matsuda, T. Yamaguchi, C. Tanikawa, M. Ogawa, Y.
Nakamura and H. Arakawa: Identification of fractalkine, a CX3C-type chemokine, as a direct
target of p53. Cancer Research, 60:3722-3726, 2000
573. L. C. McCarthy, M.-T. Bihoreau, S. L. Kiguwa, J. Browne, T. K. Watanabe, H. Hishigaki, A. Tsuji,
S. Kiel, C. Webber, M. E. Davis, C. Knights, A. Smith, R. Critcher, P. Huxtall, J. R. Hudson, Jr., T.
Ono, H. Hayashi, T. Takagi, Y. Nakamura, A. Tanigami, P. N. Goodfellow, G. M. Lathrop and M.
R. James: A whole-genome radiation hybrid panel andframework map of the rat genome.
Mammalian Genome, 11:791-795, 2000
574. T. Kawasoe, Y. Furukawa, Y. Daigo, T. Nishiwaki, H. Ishiguro, M. Fujita, S. Satoh, N. Miwa, Y.
Nagasawa, Y. Miyoshi, M. Ogawa and Y. Nakamura: Isolation and characterization of a novel
human gene, DRCTNNB1A, the expression of which is down-regulated by β-catenin. Cancer
Research, 60:3354-3358, 2000
575. M. Nakanishi, C. Sakakura, Y. Fujita, R. Yasuoka, H. Aragane, K. Koide, A. Hagiwara, T.
Yamaguchi, Y. Nakamura, T. Abe, J. Inazawa, and H. Yamagishi: Genomic alterations in primary
gastric cancers analyzed by comparative genomic hybridization and clinicopathological factors.
Hepato-Gastroenterology, 47:658-662, 2000
576. T.K. Watanabe, T. Ono, S. Okuno, A. Mizoguchi-Miyashita, Y. Yamasaki, N. Kanemoto, H.
Hishigaki, K. Oga, E. Takahashi, Y. Irie, M. Bihoreau, M. R. James, G.M. lathrop, T. Takagi, Y.
Nakamura, and A. Tanigami: Characterization of newly developed SSLP markers for the rat.
Mammalian Genome, 11:300-305, 2000
577. M. Higashiyama, Y. Miyoshi, K. Kodama, H. Yokouchi, K. Takami, M. Nishijima, T. Nakayama, H.
Kobayashi, K. Minamigawa, and Y. Nakamura: p53-regulated GML gene expression in non-small
cell lung cancer: a promising relationship to cisplatin chemosensitivity. Europian Journal of
Cancer, 36:489-495, 2000
578. M. Horie, Y. Mitsumoto, H. Kyushiki, N. Kanemoto, A. Watanabe, Y. Taniguchi, N. Nishino, T.
Okamoto, M. Kondo, T. Mori, K. Noguchi, Y. Nakamura, E. Takahashi, and A. Tanigami:
Identification and characterization of TMEFF2, a novel survival factor for hippocampal and
mesencephalic neurons. Genomics, 67:146-152, 2000
579. M. Murata, K. Iwao, Y. Miyoshi, Y. Nagasawa, M. Yabu, S. Himeno, K. Imanishi, M. Ohsawa, H.
Wada, S. Tominaga, T. Shimano, T. Kobayashi, and Y. Nakamura: Activation of β-catenin gene
by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis. Cancer
Letters, 159:73-78, 2000
580. H. Akashi, H.-J. Han, M. Iizaka, and Y. Nakamura: Growth-suppressive effect of NSAIDs on 11
colon-cancer cell lines and fluorescence differential display of genes whose expression is
influenced by sulindac. International Journal of Cancer, 88:873-880, 2000
581. T. Yamauchi, M. Tada, K. Houkin. T. Tanaka, Y. Nakamura, S. Kuroda, H. Abe. T. Inoue, K.
Ikezaki, T. Matsushima, M. Fukui: Linkage of familial Moyamoya disease (spotaneous occlusion
of the circle of Willis) to chromosome 17q25. Stroke, 31:930-935, 2000
582. S. Matsumoto, K. Minobe, Y. Utada, K. Furukawa, M. Onda, G. Sakamoto, F. Kasumi, Y.
Nakamura, and M. Emi: Loss of heterozygosity at 3p24-p25 as a prognostic factor in breast
cancer. Cancer Letters, 152:63-69, 2000
583. W.-M. Qu, T. Miyazaki, M. Terada, L.-M. Lu, M. Nishihara, A. Yamada, S. Mori, Y. Nakamura, H.
Ogasawara, C. Yazawa, S. Nakatsuru, and M. Nose: Genetic dissection of vasculitis in MRL/lpr
lupus mice: a novel susceptibility locus involving the CD72c Allele. Eur. J. Immunolo.,
30:2027-2037, 2000
584. M. Murata, K. Iwao, Y. Miyoshi, Y. Nagasawa, T. Ohta, K. Shibata, K. Oda, H. Wada, S.
Tominaga, Y. Matsuda, M. Ohsawa, Y. Nakamura and T. Shimano: Molecular and biological
analysis of carcinoma of the small intestine: βcatenin gene mutation by interstitial deletion
involving exon 3 and replication error phenotype. Am. J. Gastroenterology, 95:1576-1580, 2000
585. K. Ono, T. Tanaka, T. Tsunoda, O. Kitahara, C. Kihara, A. Okamoto, K. Ochiai, T. Takagi, and Y.
Nakamura: Identification by cDNA microarray of genes Involved in ovarian carcinogenesis.
586. T. Seki, T. Tanaka, and Y. Nakamura: Genomic structure and multiple single-nucleotide
polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene. Journal of Human
Genetics, 45:299-302, 2000
587. K. Oda, H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori, K. Tamai, T.
Tokino, Y. Nakamura, and Y. Taya: p53AIP1, a potential mediator of p53-dependent apoptosis,
and its regulation by Ser-46-phosphorylated p53. Cell, 102:849-862, 2000
588. K. Yamada, H. Tomita, K. Yoshiura, S. Kondo, K. Wakui, Y. Fukushima, S. Ikegawa, Y.
Nakamura, T. Amemiya, and N. Niikawa: An autosomal dominant posterior polar cataract locus
maps to human chromosome 20p12-q12. Eur. J. Human Genetics, 8:535-539, 2000
589. Y. Utada, M. Emi, S. Haga, M. Yoshomoto, F. Kasumi, F. Akiyama, G. Sakamoto, S. Haga, T.
Kajiwara, and Y. Nakamura: Allelic loss at 1p34-36 predict poor prognosis in node-negative
breast cancer. Clinical Cancer Research, 6:3193-3198, 2000
590. Z.-Q. Yang, I. Imoto, Y. Fukuda, A. Pimkhaokham, Y. Shimada, M. Imamura, S. Sugano, Y.
Nakamura, and J. Inazawa: Identification of a novel gene, GASC1, with an amplicon at 9p23-24
frequently detected in esophageal cancer cell lines. Cancer Research, 60:4735-4739, 2000
591. M.-S. Wu, K. Tani, H. Sugiyama, H. Hibino, K. Izawa, T. Tanabe, Y. Nakazaki, H. Ishii, J. Ohashi,
H. Hohjoh, T. Iseki, A. Tojo, Y. Nakamura, Y. Tanioka, K. Tokunaga, and S. Asano: MHC (Major
Histocompatibility Complex)-DRB genes and polymorphisms in common marmoset. Journal of
Molecular Evolution, 51:214-222, 2000
592. A. Pimkhaokham, Y. Shimada, Y. Fukuda, N. Kurihara, I. Imoto, Z.-Q. Yang, M. Imamura, Y.
Nakamura, and J. Inazawa: Nonrandoom chromosomal imbalances in esophageal squamous cell
carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.
593. J. Sasaki, K. Ishikawa, K. Kobayashi, E. Kondo-Iida, M. Fukuyama, H. Mizusawa, S. Takashima,
Y. Sasakihara, Y. Nakamura, and T. Toda: Neuronal expression of the fukutin gene. Human
594. M.E. Nita, S.K. Ono-Nita, N. Tsuno, O. Tominaga, T. Takenoue, E. Sunami, J. Kitayama, Y.
Nakamura, and H. Nagawa: Bcl-XL antisense sensitizes human colon cancer cell line to
5-fluorouracil. Japanese Journal of Cancer Research, 91:825-832, 2000
595. T. Nakajima, M. Kutabayashi, Y. Ohyama, Y. Kaneko, T. Furukawa, T. Itoh, Y. Taniguchi, T.
Tanaka, Y. Nakamura, M. Hiraoka, and R. Nagai: Characterization of S818L mutation in HERG
c-terminus in LQT2; Modification of activation-deactivation gating properties. FEBS Letters,
481:197-203, 2000
596. M. Fujita, Y. Furukawa, Y. Nagasawa, M. Ogawa and Y. Nakamura: Down-regulation of
monocyte chemotactic protein-3 (MCP-3) by activated β-catenin. Cancer Research,
60:6683-6687, 2000
597. F. Kasai, E. Takahashi, K. Koyama, K. Terao, Y. Suto, K. Tokunaga, Y. Nakamura, and M. Hirai:
Comparative FISH mapping of the ancestral fusion point of human chromosome 2. Chromosome
Research, 8:727-735, 2000
598. H. Ohigashi, O. Ishikawa, Y. Sasaki, T. Yamada, H. Furukawa, S. Imaoka, T. Kasugai, S. Ishiguro,
K. Ueda, Y. Miyoshi, and Y. Nakamura: K-ras point mutation in the nerve plexuses around the
superior mesenteric artery in respectable adenocarcinoma of the pancreatic head. Arch Surg.,
135:1450-1455, 2000
599. S. Ikegawa, M. Sano, Y. Koshizuka, and Y. Nakamura: Isolation, characterization, and mapping
of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenetics Cell Genetics, 90:291-297,
2000
600. Y. Fukuda, N. Kurihara, I. Imoto, K. Yasui, M. Yoshida, K. Yanagihara, J.G. Park, Y. Nakamura, J.
Inazawa: CD44 is a potential target of amplification within the 11p13 amplicon detected in gastric
cancer cell lines. Genes Chromosomes and Cancer, 29:315-324, 2000
601. M. Kato, K. Yano, F. Matsuo, H. Saito, T. Katagiri, H. Kurumizaka, M. Yoshimoto, F. Kasumi, F.
Akiyama, G. Sakamoto, H. Nagawa, Y. Nakamura, and Y. Miki: Identification of Rad51 alteration
in patients with bilateral breast cancer. Journal of Human Genetics, 45:133-137, 2000
602. M. Sakamoto, J. Ono, S. Okada, Y. Nakamura, and H. Kurahashi: Genetic alteration of the DCX
gene in Japanese patients with subcortical laminar heterotopia or isolated lissencephaly
sequence. Journal of Human Genetics, 45:167-170, 2000
603. Y. Nakatsuru, K. Minami, A. Yoshikawa, JJ. Zhu, H. Oda, P. Masahito, N. Okamoto, Y. Nakamura,
T. Ishikawa: Eel WT1 sequence and expression in spontaneous nephroblastomas in Japanese
eel. Gene, 245:245-251, 2000
604. A. Iida, M. Emi, R. Matsuoka, E. Hiratsuka, K. Okui, H. Ohashi, J. Inazawa, Y. Fukushima, T. Imai,
Y. Nakamura: Identification of a gene disrupted by inv(11)(q3.5;q25) in a patient with leftright axis
malformation. Human Genetics, 106:277-287, 2000
605. S. Ikegawa, H. Ohashi, T. Ogata, A. Honda, M. Tsukahara, T. Kubo, M. Kimizuka, M. Shimode, T.
Hasegawa, G. Nishimura, Y. Nakamura: Novel and Recrrent EBP Mutations in X-Linked
Dominant Chondrodysplasia Punctata. American Journal of Medical Genetics, 94:300-305, 2000
606. T. Toda, K. Kobayashi, E. Kondo-Iida, J. Sasaki, and Y. Nakamura The Fukuyama congenital
muscular dystrophy story (review article) Neuromuscular Disorders, 10:153-159, 2000
607. A. Nishikawa, K. Kobayashi, S. Sagae, S. Ishioka, A. Nishikawa, Y. Kanamori, T. Minaguchi, Y.
Nakamura, T. Tokino, and R.Kudo:
A single nucleotide polymorphism in the matrix
metalloproteinase-1 promoter in endometrial carcinomas Japanese Journal of Cacner Research,
91:612-615, 2000
608. C. Sakakura, A. Hagiwara, R. Yasuoka, Y. Fujita, M. Nakanishi, K. Masuda, A. Kimura, Y.
Nakamura, J. Inazawa, T. Abe, H. Yamagishi: Amplification and over-expression of the AIB1
nuclear receptor co-activator gene in primary gastric cancers. International Journal of Cancer,
89:217-223, 2000
609. A. Hirano, Y. Utada, S. Haga, T. Kajiwara, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi:
Allelic losses as prognostic markers for breast cancers. International Journal of Clinical Oncology,
6:6-12, 2001
610. K. Kyo, T. Muto, H. Nagawa, G. M. Lathrop, and Y. Nakamura: Associations of distinct variants of
the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. Journal of Human
Genetics, 46:5-20, 2001
611. H. Iwasa, M. Kurabayashi, R. Nagai, Y. Nakamura, and T. Tanaka: Multiple single-nucleotide
polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome.
612. O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, E. M. Nita, H. Ogasawara,
J. Okutsu, H. Zenbutsu, N. Shiraishi, T. Takagi, Y. Nakamura, and T. Tsunoda: Alterations of
gene expression during colorectal carcinogenesis revealed by cDNA microarrays after
laser-capture microdissection of tumor tissues and normal epithelia. Cancer Research,
61:3544-3549, 2001
613. T. Itoh, K. Kikuchi, Y. Odagawa, S. Takata, K. Yano, S. Okada, N. Haneda, S. Ogawa, O. Nakano,
Y. Kawahara, H. Kasai, T. Nakayama, T. Fukutomi, H. Sakurada, A. Shimizu, Y. Yazaki, R. Nagai,
Y. Nakamura, and T. Tanaka: Correlation of genetic etiology with response to β-adrenergic
blockade among symptomatic patients with familial long-QT syndrome. Journal of Human
Genetics, 46:38-40, 2001
614. S. Takeoka, M. Unoki, Y. Onouchi, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, Ituro Inoue, Y.
Nakamura, and M. Tamari: Amino-acid substitutions in the IKAP gene product significantly
increase risk for bronchial asthma in children. Journal of Human Genetics, 46:57-63, 2001
615. R. Yamada, T. Tanaka, M. Unoki T. Nagai, T. Sawada, Y. Ohnishi, T, Tsunoda, M. Yukioka, A.
Maeda, K. Suzuki, H. Tateishi, T. Ochi, Y. Nakamura, and K. Yamamoto: Association between a
single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid
arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two
genetic loci have on susceptibility to the disease. Am. J. Human Genetics, 68:674-685, 2001
616. M. Matsushima-Nishiu, M. Unoki, K. Ono, T. Tsunoda, T. Minaguchi, H. Kuramoto, M. Nishida, T.
Satoh, T. Tanaka, and Y. Nakamura: Growth and gene expression profiles analyses of
endometrial cancer cells expressing exogenous PTEN. Cancer Research, 61:3741-3749, 2001
617. T. Kato, S. Satoh, H. Okabe, O. Kitahara, K. Ono, C. Kihara, T. Tanaka, T. Tsunoda, Y. Yamaoka,
Y. Nakamura, and Y. Furukawa: Isolation of a novel human gene, MARKL1, homologous to
MARK3 and its involvement in hepatocellular carcinogenesis. Neoplasia, 3:4-9, 2001
618. C. Suzuki, M. Unoki, and Y. Nakamura: Identification and allelic frequencies of novel
single-nucleotide polymorphisms in the DUSP1 and BTG1 genes. Journal of Human Genetics,
46:155-157, 2001
619. H. Okabe, S. Satoh, T. Kato, O. Kitahara, R. Yanagawa, Y. Yamaoka, T. Tsunoda, Y. Furukawa
and Y. Nakamura: Genome-wide analysis of gene expression in human hepatocellular
carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and
tumor progression. Cancer Research, 6:2129-2137, 2001
620. T. Watanabe, S. Okuno, T. Ono, Y. Yamasaki, K. Oga, A. Mizoguchi-Miyakita, H. Miyano, M.
Suzuki, H. Momota, Y. Goto, H. Shinomiya, H. Hishigaki, I. Hayashi, T. Asai, S. Wakitani, T.
Takagi, Y. Nakamura, and A. Tanigami: Single-allele correction of the Dmo1 locus in congenic
animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF
rat. Clin. and Exp. Pharmacology and Psysiology, 28:28-42, 2001
621. A. Iida, A. Sekine, S. Saito, Y. Kitamura, T. Kitamoto, S. Osawa, C. Mishima and Y. Nakamura:
Catalog of 320 single nucleotide polymorphisms (SNPs) in 20 quinone oxidoreductase and
sulfotransferase genes. Journal of Human Genetics, 46:225-240, 2001
622. O. Watanabe, M. Tamari, K. Natori, Y. Onouchi, Y. Shiomoto, I. Hiraoka and Y. Nakamura: Loci
on murine chromosomes 7 and 13 that modify the phenotype of the NOA mouse, an animal
model of atopic dermatitis. Journal of Human Genetics, 46:221-224, 2001
623. A. Sekine, S. Saito, A. Iida, Y. Mitsunobu, S. Higuchi, S. Harigae, and Y. Nakamura: Identification
of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2,
AANAT, ARD1 and L1CAM in the Japanese population. Journal of Human Genetics, 46:314-319,
2001
624. S. Saito, A. Iida, A. Sekine, C. Eguchi, Y. Miura, and Y. Nakamura: Seventy genetic variations in
human microsomal and soluble epoxide hydrolase genes (EPHX1 and EPHX2) in the Japanese
population. Journal of Human Genetics, 46:325-329, 2001
625. K. Kobayashi, J. Sasaki, E. Kondo-Iida, Y. Fukuda, M. Kinoshita, Y. Sunada, Y. Nakamura, and T.
Toda: Structural organization, complete genomic sequences and mutational analyses of the
Fukuyama-type congenital muscular dystrophy gene, fukutin. FEBS Letters, 489:192-196, 2001
626. A. Hirano, M. Emi, M. Tsuneizumi, Y. Ueda, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto,
S. Haga, T. Kajiwara, and Y. Nakamura: Allelic losses of loci at 3p25.1, 8p22, 13q12, 17p13.3
and 22q13 correlate with postoperative recurrence in breast cancer. Clinical Cancer Research,
7:876-882, 2001
627. Y. Nakamura: Isolation of disease-associated genes through genome analysis and their clinical
application. The Keio Journal of Medicine, 50:134-140, 2001
628. A. Iida, S. Saito, A. Sekine, T. Kitamoto, Y. Kitamura, C. Mishima, S. Osawa, K. Kondo, S.
Harigae, and Y. Nakamura: Catalog of 434 single-nucleotide polymorphisms (SNPs) in genes of
the alcohol dehydrogenase, glutathione S-transferase, and nicotinamide ademine dinucleotide,
reduced (NADH) ubiquinone oxidoreductase families. Journal of Human Genetics, 46:385-407,
2001
629. H. Ishiguro, T. Tsunoda, T. Tanaka, Y. Fujii, Y. Nakamura, and Y. Furukawa: Identification of
AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas
of the lung, liver, colon and kidney. Oncogene, 20:5062-5066, 2001
630. M. Unoki and Y. Nakamura: Growth-suppressive effects of BPOZ and EGR2, two genes involved
in the PTEN signaling pathway. Oncogene, 20:4457-4465, 2001
631. C. Kihara, T. Tsunoda, T. Tanaka, H. Yamana, Y. Furukawa, K. Ono, O. Kitahara, H. Zenbutsu, R.
Yanagawa, K. Hirata, T. Takagi, and Y. Nakamura: Prediction of sensitivity of esophageal tumors
to adjuvant chemotherapy by cDNA microarray analysis of gene-expression profiles. Cancer
Research, 61:6474-6479, 2001
632. Y. Furukawa, T. Kawasoe, Y. Daigo, T. Nishiwaki, H. Ishiguro, M. Takahashi, J. Kitayama, and Y.
Nakamura: Isolation of a novel human gene, ARHGAP9, encoding a Rho-GTPase activating
protein. Biochemical and Biophysical Research Communications, 284:643-649, 2001
633. Y.-M. Lin, K. Ono, S. Satoh, H. Ishiguro, M. Fujita, N. Miwa, T. Tanaka, T. Tsunoda, Y. Nakamura,
and Y. Furukawa: Identification of AF17 as a downstream gene of the β-catenin/T-cell factor
pathway and its involvement in colorectal carcinogenesis. Cancer Research, 61:6345-6349, 2001
634. M. Furuhashi, K. Yagi, H. Yamamoto, Y. Furukawa, S. Shimada, Y. Nakamura, A. Kikuchi, K.
Miyazono, and M. Kato: Axin facilitates Smad3 activation in the transforming growth factor-β
signaling pathway. Molecular and Cellular Biology, 21:5132-5141, 2001
635. R. Yanagawa, Y. Furukawa, T. Tsunoda, O. Kitahara, K. Murata, O. Ishikawa, and Y. Nakamura:
Genome-wide screening of genes showing altered expression in liver metastases of human
colorectal cancers by cDNA microarray. Neoplasia, 3:395-401, 2001
636. Y. Ohnishi, T. Tanaka, K. Ozaki, R. Yamada, H. Suzuki and Y. Nakamura: A high-throughput
SNP typing system for genome-wide association studies. Journal of Human Genetics,
46:471-477, 2001
637. H. Iwasa, M. Kurabayashi, R. Nagai, Y. Nakamura, T. Tanaka: Genetic variations in five genes
involved in the excitement of cardiomyocytes. Journal of Human Genetics, 46:549-552, 2001
638. S. Saito, A. Iida, A. Sekine, Y. Miura, T. Sakamoto, C. Ogawa, S. Kawauchi, S. Higuchi, and Y.
Nakamura: Identification of 197 genetic variations in six human methyltransferase genes in the
Japanese population. Journal of Human Genetics, 46:529-537, 2001
639. S. Okamura, H. Arakawa, T. Tanaka, H. Nakanishi, C. C. Ng, Y. Taya, M. Monden, and Y.
Nakamura: p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Molecular Cell,
8:85-94, 2001
640. A. Iida, S. Saito, A. Sekine, Y. Kitamura, K. Kondo, C. Mishima, S. Osawa, S. Harigae, and Y.
Nakamura: High-density single-nucleotide polymorphism (SNP) map of the 150-kb region
corresponding to the human ATP-binding cassette transporter A1(ABCA1) gene. Journal of
641. M. Fujita, Y. Furukawa, T. Tsunoda, T. Tanaka, M. Ogawa and Y. Nakamura: Up-regulation of the
ENC1 (ectodermal-neural cortex 1) gene, a downstream target of the β-catenin/T-cell factor
complex, in colorectal carcinomas. Cancer Research, 61:7722-7726, 2001
642. Y. Suzuki, H. Taira, T. Tsunoda, J. Mizushima-Sugano, J. Sese, H. Hata, T. Ota, T. Isogai, T.
Tanaka, S. Morishita, K. Okubo, Y. Sakaki, Y. Nakamura, A. Suyama, and S. Sugano: Diverse
transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO reports,
2:388-393, 2001
643. S. Okuno, T. K. Watanabe, T. Ono, K. Oga, A. Mizoguchi-Miyakita, Y. Yamasaki, Y. Goto, H.
Shinomiya, H. Momota, H. Miyano, I. Hayashi, T. Asai, M. Suzuki, Y. Harada, H. Hishigaki, S.
Wakitani, T. Takagi, Y. Nakamura, and A. Tanigami: Effects of Dmo1 on obesity, dyslipiaemia
and hyperglycemia in the Otsuka Long Evans Tokushima Fatty strain. Genet. Res., 77:183-190,
2001
644. Y. Suzuki, T. Tsunoda, J. Sese, H. Taira, J. Mizushima-Sugano, H. Hata, T. ota, T. Isogai, T.
tanaka, Y. Nakamura, A. Suyama, Y. Sakaki, S. Morishita, K. Okubo, and S. Sugano:
Identification and characterization of the potential promoter regions of 1031 kinds of human
genes. Genome Research, 11:677-684, 2001
645. K. Yasui, I. Imoto, Y. Fukuda, A. Pimkhaokham, Z.Q. Yang, T. Naruto, Y. Shimada, Y. Nakamura,
J. Inazawa: Identification of target genes within an amplicon at 14q12-q13 in esophageal
squamous cell carcinoma. Genes Chromosomes and Cancer, 32:112-118, 2001
646. C. Sakakura, A. Hagiwara, R. Yasuoka, Y. Fujita, M. Nakanishi, K. Masuda, K. Shimomura, Y.
Nakamura, J. Inazawa, T. Abe, H. Yamagishi: Tumour-amplified kinase BTAK is amplified and
overexpressed in gastric cancers with possible involvement in aneuploid formation. British
647. A. Iida, S. Saito, A. Sekine, S. Harigae, S. Osawa, C. Mishima, K. Kondo, Y. Kitamura, and Y.
Nakamura: Catalog of 46 single nucleotide polymorphisms (SNPs) in the microsomal glutathione
S-transferase 1 (MGST1) gene. Journal of Human Genetics, 46:590-594, 2001
648. A. Iida, Y. Ohnishi, K. Ozaki, Y. Ariji, A. Inose, M. Takahashi, Y. Nakamura, and T. Tanaka:
High-density single-nucleotide polymorphism (SNP) map in the 96-kb region containing the entire
human DiGeorge syndrome critical region 2 (DGCR2) gene at 22q11.2. Journal of Human
Genetics, 46:604-608, 2001
649. Y. Yamanaka, M. Tamar, T. Nakahata and Y. Nakamura: Gene-expression profiles of human
small airway epithelial cells treated with low doses of 14- and 16-membered macrolides.
650. A. Iida, S. Saito, A. Sekine, C. Mishima, K. Kondo, Y. Kitamura, S. Harigae, S. Osawa, and Y.
Nakamura: Catalog of 258 single nucleotide polymorphisms (SNPs) in genes encoding three
organic anion transporters, three organic anion-transporting polypeptides, and three
NADH:ubiquinone oxidoreductase flavoproteins. Journal of Human Genetics, 46:668-683, 2001
651. M. Murata, Y. Miyoshi, M. Ohshima, K. Shibata, T. Ohta, Y. Imai, M. Nishikawa, K. Iwao, H.
Tateishi, T. Shimano, T. Kobayashi, and Y. Nakamura: Accumulation of β-catenin in the
cytoplasm and the nuclei during the early hepatic tumorigenesis. Hepatology Research,
21:126-135, 2001
652. M. Murata, Y. Miyoshi, K. Iwao, H. Wada, K. Shibata, H. Tateishi, T. Shimano, M. Ohsawa, Y.
Imai, M. Nishikawa, T. Kobayashi, and Y. Nakamura: Combined hepatocellular/cholangiocellular
carcinoma with sarcomatoid features: genetic analysis for histogenesis. Hepatology Research,
21:220-227, 2001
653. N. Miwa, M. Furuse, S. Tsukita, N. Niikawa, Y. Nakamura and Y. Furukawa: Involvement of
Claudin-1 in the β-catenin /Tcf signaling pathway and its frequent up-regulation in human
colorectal cancers. Oncology Research, 12:469-476, 2001
654. T. Yamaguchi, K. Matsuda, Y. Sagiya, M. Iwadate, M. A. Fujino, Y. Nakamura, and H. Arakawa:
p53R2-dependent pathway for DNA synthesis in a p53-regulated cell-cycle checkpoint. Cancer
Research, 61:8256-8262, 2001
655. S. Haga, M. Emi, A. Hirano, Y. Utada, T. Kajiwara, F. Akiyama, G. Sakamoto, K. Takahashi, T.
Tada, F. Kasumi, and Y. Nakamura: Association of allelic losses at 3p25.1, 13q12 or 17p13.3
woth poor prognosis in breast cancers with lymph node metastasis. Japanese Journal of Cancer
Research, 92:1199-1206, 2001
656. M. Tsuneizumi, M. Emi, H. Nagai, H. Harada, G. Sakamoto, F. Kasumi,S. Inoue, T. Kazui and Y.
Nakamura: Overexpression of the EBAG9 gene at 8q23 associated with early-stage breast
cancer. Clinical Cancer Research, 7:3526-3532, 2001
657. O. Guittet, P. Haansson, N. Voevodskaya, S. Fridd, A. Gralund, H. Arakawa, Y. Nakamura, and L.
Thelander: Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the
R1 protein, which is expressed both in resting cells in response to DNA damage and in
proliferating cells. Journal of Biological Chemistry, 276:40647-40651, 2001
658. S. Iwashita, K. Koyama, and Y. Nakamura: VNTR sequence on human chromosome 11p15 that
affects transcriptional activity. Journal of Human Genetics, 46:717-721, 2001
659. H. Nakagawa, R.-B.Chadwick, P. Peltomaki, C. Plass, Y. Nakamura, A. de la Chapelle: Loss of
imprinting of the insulin-like growth factor Ⅱ gene occurs by biallelic methylation in a core region
of H19-associated CTCF-binding sites in colorectal cancer. Proc. Natl. Acad. Sci. USA,
98:591-596, 2001
660. Y. Koshizuka, S. Ikegawa, M. Sano, K. Nakamura, and Y. Nakamura: Isolation of novel mouse
genes associated with ectopic osscification by differential display method using ttw, a mouse
model for ectopic ossification. Cytogenetics Cell Genetics, 94:163-168, 2001
661. Y. Koshizuka, S. Ikegawa, M. Sano, K. Nakamura, Y. Nakamura: Isolation, characterization, and
mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family.
Genomics, 72:252-259, 2001
662. M. Aoki, M. Tamatani, M. Taniguchi, A. Yamaguchi, Y. Bando, K. Kasai, Y. Miyoshi, Y. Nakamura,
M.P. Viteke, M. Tohyam, H. Tanaka, and H. Sugimoto:
Hypothermic treatment restores
glucose regulated protein 78 (GRP78) expression in ischemic brain. Molecular Brain Research,
95:117–128, 2001
663. G.J. Liefers, R.A.E.M. Tollenaar, Y. Nakamura and C.J.H. van de Velde: Genetic cancer
syndromes and large-scale gene expression analysis: applications in surgical oncology. (Review)
European Journal of Surgical Oncology, 27:343-348, 2001
664. The Japan Society of Human Genetics, Council Committee of Ethics, I. Matsuda, N. Niikawa, K.
Sato, K. Suzumori, Y. Fukushima, N, Fujiki, I. Kanazawa, Y. Nakamura, S. Yonemoto, and Y.
Nakagome: Guidelines for genetic testing Journal of Human Genetics, 46:163-165, 2001
665. T. Mori, Y. Anazawa, M. Iiizumi, S. Fukuda, Y. Nakamura, and H. Arakawa: Identification of the
interferon regulatory factor 5gene (IRF-5) as a direct target for p53. Oncogene, 21:2914-2918,
2002
666. K. Ochi, T. Mori, Y. Toyama, Y. Nakamura and H. Arakawa: Identification of semaphorin3B as a
direct target of p53. Neoplasia, 4:82-87, 2002
667. K. Matsuda, K. Yoshida, Y. Taya, K. Nakamura, Y. Nakamura, H. Arakawa: p53AIP1 regulates
the mitochondrial apoptotic pathway. Cancer Research, 62:2883-2889, 2002
668. M. Iiizumi, H. Arakawa, .T Mori, A. Ando, and Y. Nakamura: Isolation of a novel gene, CABC1,
encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex.
669. A. Iida, S. Saito, A. Sekine, K. Kondo, C. Mishima, Y. Kitamura, S. Harigae, S. Osawa, and Y.
Nakamura: Thirteen single nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4
(ADH4) gene locus. Journal of Human Genetics, 47:74-76, 2002
670. S. Dan, T. Tsunoda, O. Kitahara, R. Yanagawa, H. Zembutsu, T. Katagiri, K. Yamazaki, Y.
Nakamura, and T. Yamori: An integrated database of chemosensitivity to 55 anticancer drugs and
gene expression profiles of 39 human cancer cell lines. Cancer Research, 62:1139-1147, 2002
671. A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y.
Nakamura: Catalog of 77 single nucleotide polymorphisms (SNPs) in the carbohydrate
sulfotransferase 1 (CHST1) and carbohydrate sulfotransferase 3 (CHST3) genes. Journal of
672. H. Zembutsu, Y. Ohnishi, T. Tsunoda, Y. Furukawa, T. Katagiri, Y. Ueyama, N. Tamaoki, T.
Nomura, O. Kitahara, R. Yanagawa, K. Hirata, and Y. Nakamura: Genome-wide cDNA microarray
screening to correlate gene-expression profiles with sensitivity of 85 human-cancer xenografts to
anticancer drugs. Cancer Research, 62:518-527, 2002
673. M. Hirakawa, T. Tanaka, Y. Hashimoto, M. Kuroda, T. Takagi, and Y. Nakamura: JSNP: a
database of common gene variations in the Japanese population. Nucleic Acids Research,
30:158-162, 2002
674. S. Saito, A. Iida, A. Sekine, Y. Miura, C. Ogawa, S. Kawauchi, S. Higuchi, and Y. Nakamura: 326
genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B
(ABCB/MDR/TAP), in the Japanese population. Journal of Human Genetics, 47:38-50, 2002
675. T. Takei, A. Iida, K. Nitta, T. Tanaka, Y. Ohnishi, R. Yamada, S. Maeda, T. Tsunoda, S. Takeoka,
K. It o, K. Honda, K. Uchida, K. Tsuchiya, Y. Suzuki, T. Fujioka, T. Ujiie, Y. Nagane, S. Miyano, I.
Narita, F. Gejyo, H. Nihei, Y. Nakamura: Association between single-nucleotide polymorphisms in
selectin genes and IgA nephropathy. Am. J. Human Genetics, 70:781-786, 2002
676. M. Doi, A. Nagano and Y. Nakamura: Genome-wide screening by cDNA microarray of genes
associated with matrix mineralization by human mesenchymal stem cells in vitro. Biochemical
and Biophysical Research Communications, 290:381-390, 2002
677. H. Yamanaka, N. Hashimoto, K. Koyama, H. Nakagawa, Y. Nakamura, and K. Noguchi:
Expression of Apc2 during mouse development. Gene Expression Patterns, 1:107-114, 2002
678. M. Tsuneizumi, M. Emi, A. Hirano, Y. Utada, K. Tsumagari, K. Takahashi, F. Kasumi, F. Akiyama,
G. Sakamoto, T. Kazui and Y. Nakamura: Assocaition of allelic loss at 8p22 with poor prognosis
amang breast cancer cases treated with high-dose adjuvant chemotherapy. Cancer Letters,
180:75-82, 2002
679. M. Tachikawa, Y. Nagai, K .Nakamura, K. Kobayashi, T. Fujiwara, H-J. Han, Y. Nakabayashi, Y.
Ichikawa, J. Goto, I. Kanazawa, Y. Nakamura, and T. Toda: Identification of CAG
repeat-containing genes expressedin human brain as candidate genes for autosomal dominant
spinocerebellar ataxias and other neurodegenerative diseases. Journal of Human Genetics,
47:275-278, 2002
680. T. Nagahata, A. Hirano, Y. Utada, S. Tsuchiya, K. Takahashi, T. Tada, M. Makita, F. Kasumi, F.
Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Correlation of allelic losses and
clinicopathological factors in 504 primary breast cancers. Breast Cancer, 9:208-215, 2002
681. D.G. Duda, M. Sunamura, L. Lozonshi, T. Yokoyama, T. Yatsuoka, A. Horii, K. Tani, S. Asano, Y.
Nakamura, and S. Matsuno: Overexpression of the p53-inducible brain-specific angiogenesis
inhibitor 1 suppresses efficiently tumour angiogenesis. British Journal of Cancer, 86:490-496,
2002
682. Y. Sasaki, S. Ishida, I. Morimoto, T. Yamashita, T. Kojima, C. Kihara, T. Tanaka, K. Imai, Y.
Nakamura, and T. Tokino: The p53 family member genes are involved in the notch signal
pathway. Journal of Biological Chemistry, 277:719-724, 2002
683. M. Iizaka, Y. Furukawa, T. Tsunoda, H. Akashi, M. Ogawa, and Y. Nakamura: Expression profile
analysis of colon cancer cells in response to sulindac or aspirin. Biochemical and Biophysical
Research Communications, 292:498-512, 2002
684. K. Miura, E. D. Bowman, R. Simon, A. C. Peng, A. I. Robles, R. T. Jones, T. Katagiri, P. He, H.
Mizukami, L. Charboneau, T. Kikuchi, L. A. Liotta, Y. Nakamura, and C. C. Harris: Laser capture
microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco
smoking- and prognosis-related molecular profiles. Cancer Research, 62:3244-3250, 2002
685. J. Kamogawa, M.Terada, S. Mizuki, M, Nishihara, H. Yamamoto, S, Mori, Y. Abe, K. Morimoto, S.
Nakatsuru, Y. Nakamura, and M. Nose: Arthritis in MRL/lpr Mice Is Under the Control of Multiple
Gene Loci With an Allelic Combination Derived From the Original Inbred Strains. Arthritis &
Rheumatism, 46:1067-1074, 2002
686. T. Mori, Y. Anazawa, K. Matsui, S. Fukuda, Y. Nakamura, and H. Arakawa: Cyclin K as a direct
transcriptional target of the p53 tumor suppressor. Neoplasia, 4:268-274, 2002
687. S. Saito, A. Iida, A. Sekine, Y. Miura, C. Ogawa, S. Kawauchi, S. Higuchi, and Y. Nakamura:
Identification of 779 genetic variations in eight genes encoding members of the ATP-binding
cassette, subfamily C (ABCC/MRP/CFTR). Journal of Human Genetics, 47:147-171, 2002
688. S. Higuchi, Y. Nakamura and S. Saito: Characterization of a VNTR polymorphism in the coding
region of the CEL gene. Journal of Human Genetics, 47:213-215, 2002
689. Y.-M. Lin, Y. Furukawa, T. Tsunoda, C.-T. Yue, K.-C. Yang, and Y. Nakamura: Molecular
diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in
adenomas and carcinomas. Oncogene, 21:4120-4128, 2002
690. H. Iwasa, T. Itoh, R. Nagai, Y. Nakamura, T. Tanaka: Twenty single-nucleotide polymorphisms in
four genes encording cardiac ion channels. Journal of Human Genetics, 47:208-212, 2002
691. T. Kayashima, M. Katahira, N. Harada, N. Miwa, T. Ohta, K. Yoshiura, N. Matsumoto, Y. Nakane,
Y. Nakamura, T. Kajii, N. Niikawa, and T. Kishino: Maternal Isodisomy for 14q21-24 in a man with
daiabetes mellitus. American Journal of Medical Genetics, 111:38-42, 2002
692. M. Nishiu, R. Yanagawa,S. Nakatsuka, M. Yao, T. Tsunoda, Y. Nakamura, and K. Aozasa:
Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: Identification of
genes related to disease progression. Japanese Journal of Cancer Research, 93:894-901, 2002
693. A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y.
Nakamura: Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding
human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4,
ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. Journal of Human Genetics,
47:285-310, 2002
694. O. Kitahara, T. Katagiri, T. Tsunoda, Y. Harima, and Y. Nakamura: Classification of sensitivity or
resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes
selected by cDNA microarray analysis. Neoplasia, 4:295-303, 2002
695. R. Yagyu, R. Hamamoto, Y. Furukawa, H. Okabe, T. Yamamura, and Y. Nakamura: Isolation and
characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular
carcinoma. International Journal of Oncology, 20:1173-1178, 2002
696. A. Saito-Hisaminato, T. Katagiri, S. Kakiuchi, T. Nakamura, T. Tsunoda, and Y. Nakamura:
Genome-wide profiling of gene expression in 29 normal human tissues with a cDNA microarray.
DNA Research, 9:35-45, 2002
697. F. Saito-Ohara, Y. Fukuda, M. Ito, K.L. Agarwala, M. Hayashi, M. Matsuo, I. Imoto, K. Yamakawa,
698.
699.
700.
701.
702.
703.
704.
705.
706.
707.
708.
709.
710.
711.
712.
713.
714.
715.
Y. Nakamura, and J. Inazawa: The Xq22 inversion breakpoint interrupted a novl ras-like GTPase
gene in a patient with Duchenne muscular dystrophy and profound mental reterdation. Am. J.
S. Nagayama, T. Katagiri, T. Tsunoda, T. Hosaka, Y. Nakashima, N. Araki, K. Kusuzaki, T.
Nakayama, T. Tsuboyama, T. Nakamura, M. Imamura, Y. Nakamura, and J. Toguchida:
Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray.
M. Takahashi, T. Tsunoda, M. Seiki, Y. Nakamura, and Y. Furukawa: Identification of
membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human
colorectal cancers. Oncogene, 21:5861-5867, 2002
S. Saito, A. Iida, A. Sekine, C. Ogawa, S. Kawauchi, S. Higuchi, M. Ohno, and Y. Nakamura: 906
variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde
dehydrogenases (ALDH) in the Japanese population. Journal of Human Genetics, 47:419-444,
2002
K. Inoue, K. Matsuda, M. Itoh, H. Tomoike, T. Aoyagi, R. Nagai, M. Hori, Y. Nakamura, and
T. Tanaka: Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter
gene, Znt5. Human Molecular Genetics, 11:1775-1784, 2002
H. Ishiguro, T. Shimokawa, T. Tsunoda, T. Tanaka, Y. Fujii, Y. Nakamura and Y. Furukawa:
Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.
Oncogene, 21:6387-6394, 2002
K. Yamazaki, M. Takazoe, T. Tanaka, T. Ichimori, and Y. Nakamura: Absence of mutation in the
NOD2/CARD15 gene among 483 Japanese patients with Crohn's Disease. Journal of Human
Genetics, 47:469-472, 2002
A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y.
Nakamura: Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate
glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8. Journal of Human Genetics,
47:505-510, 2002
F. Akiyama, T. Tanaka, R. Yamada, Y. Ohnishi, T. Tsunoda, S. Maeda, T. Takei, W. Obara, K. Ito,
K. Honda, K. Uchida, K. Tsuchiya, K. Nitta, K. Yumura, H. Nihei, T. Ujiie, Y. Nagane, Y. Suzuki, T.
Fujioka, I. Narita, F. Gejyo, and Y. Nakamura: Single-nucleotide polymorphisms in the class II
region of the major histocompatibility complex in Japanese patients with immunoglobulin A
nephropathy. Journal of Human Genetics, 47:532-538, 2002
S. Saito, A. Iida, A. Sekine, C. Ogawa, S. Kawauchi, S. Higuchi, and Y. Nakamura: Catalog of
238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese
M. Takahashi, M. Fujita, Y. Furukawa, R. Hamamoto, T. Shimokawa, N. Miwa, and Y. Nakamura:
Isolation of a novel human gene, APCDD1, as a direct target of the β-catenin/T-cell factor 4
complex with probable involvement in colorectal carcinogenesis. Cancer Research,
62:5651-5656, 2002
Y. Yamanaka, Y. Hamazaki, Y. Sato, K. Ito, K. Watanabe, T. Heike, T. Nakahata and Y.
Nakamura: Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA
microarrays. International Journal of Oncology, 21:803-807, 2002
Y. Kaneta, Y. Kagami, T. Katagiri, T. Tsunoda, I. Jin-nai, H. Taguchi, H. Hirai, K. Ohnishi, T. Ueda,
N. Emi, A. Tomida, T. Tsuruo, Y. Nakamura, and R. Ohno: Prediction of sensitivity to STI571
among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis. Japanese
Journal of Cancer Research, 93:849-856, 2002
H. Haga, R. Yamada, Y. Ohnishi, Y. Nakamura, and T. Tanaka: Gene-based SNP discovery as
part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in
the human genome. Journal of Human Genetics, 47:605-610, 2002
M. Horie, K. Kobayashi, S. Takeda, Y. Nakamura, G. E. Lyons, and T. Toda: Isolation and
characterization of the mouse ortholog of the Fukuyama-type congenital musclular dystrophy
gene. Genomics, 80:482-486, 2002
S. Hasegawa, Y. Furukawa, M. Li, S. Satoh, T. Kato, T. Watanabe, T. Katagiri, T. Tsunoda, Y.
Yamaoka, and Y. Nakamura: Genome-wide analysis of gene expression in intestinal-type gastric
cancers using a cDNA microarray representing 23,040 genes. Cancer Research, 62:7012-7017,
2002
K. Ozaki, Y. Ohnishi, A. Iida, A. Sekine, R. Yamada, T. Tsunoda, H. Sato, H. Sato, M. Hori, Y.
Nakamura, and T. Tanaka: Functional SNPs in the lymphotoxin-α gene that are associated with
susceptibility to myocardial infarction. Nature Genetics, 32:650-654, 2002
J. Okutsu, T. Tsunoda, Y. Kaneta, T. Katagiri, O. Kitahara, H. Zembutsu, R. Yanagawa, S.
Miyawaki, K. Kuriyama, N. Kubota, Y. Kimura, K. Kubo, F. Yagasaki, T. Higa, H.Taguchi, T.
Tobita, H. Akiyama, A. Takeshita, Y.-H. Wang, T. Motoji, R. Ohno, and Y. Nakamura: Prediction
of chemosensitivity for patients with acute myeloid leukemia, according to expression levels of 28
genes selected by genome-wide cDNA microarray analysis. Molecular Cancer Therapeutics,
1:1035-1042, 2002
S. Rokudai, N. Fujita, O. Kitahara, Y. Nakamura, and T. Tsuruo: Involvement of FKHR-dependent
716.
717.
718.
719.
720.
721.
722.
723.
724.
725.
726.
727.
728.
729.
730.
731.
732.
733.
734.
735.
736.
TRADD expression in chemotherapeutic drug-induced apoptosis. Molecular and Cellular Biology,
22:8695-8708, 2002
H. Nishimori, Y. Sasaki, K. Yoshida, H. Irifune, H. Zenbutsu, T. Tanaka, T. Aoyama, T. Hosaka, S.
Kawaguchi, T. Wada, J. Hata, J. Toguchida, Y. Nakamura, and T. Tokino: The Id2 gene is a novel
target of the transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.
Oncogene, 21:8302-8309, 2002
S.Okuno, M. Kondo, Y. Yamasaki, H. Miyano, T. Ono, T. Iwanaga, K. Omori, M. Okano, M.
Suzuki, H. Momota, H. Hishigaki, I. Hayashi, Y. Goto, H. Shinomiya, Y. Harada, T. Hirashima, N.
Kanemoto, T. Asai, S. Wakitani, T. Takagi, Y. Nakamura, A. Tanigami, and K. Watanabe:
Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF
rats. Diabetes, Obesity, and Metabolism, 4:309-318, 2002
Y. Koshizuka, H. Kawaguchi, N. Ogata, T. Ikeda, A. Mabuchi, A. Seichi, Y. Nakamura. K.
Nakamura. And S. Ikegawa: Nucleotide pyrophosphatase gene polymorphism associated with
ossification of the posterior longitudinal ligament of the spine. Journal of Bone and Mineral
Research, 17:138-144, 2002
S. Abe, T. Katagiri, A. Saito-Hisaminato, S. Usami, Y. Inoue, T. Tsunoda, and Y. Nakamura:
Identification of CRYM as a candidate responsible for non-syndromic deafness, through cDNA
microarray analysis of human cochlear and vestibular tissues. Am. J. Human Genetics, 72:73-82,
2003
S. Tsukada, M. Iwai, J. Nishiu, M. Itoh, H. Tomoike, M. Horiuchi, Y. Nakamura, and T. Tanaka:
Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor.
Circulation, :313-319, 2003
S. Abe, K. Koyama, S. Usami, Y. Nakamura: Construction and characterization of a
vestibular-specific cDNA library using T7-based RNA amplification. Journal of Human Genetics,
48:142-149, 2003
A. Iida, T. Tanaka, and Y. Nakamura: High-density SNP map of human ITR, a gene associated
with vascular remodeling. Journal of Human Genetics, 48:170-172, 2003
A. Iida, and Y. Nakamura: High-resolution SNP map in the 55-kb region containing the selectin
gene family on chromosome 1q24-q25. Journal of Human Genetics, 48:150-154, 2003
T. Kikuchi, Y. Daigo, T. Katagiri, T. Tsunoda, K. Okada, S. Kakiuchi, H. Zembutsu, Y. Furukawa,
M. Kawamura, K. Kobayashi, K. Imai, and Y. Nakamura: Expression profiles of non-small cell
lung cancers on cDNA microarrays: Identification of genes for prediction of lymph node
metastasis and sensitivity to anti-cancer drugs. Oncogene, 22:2192-2205, 2003
T. Arimoto, T. Katagiri, K. Oda, T. Tsunoda, T. Yasugi, Y. Osuga, H. Yoshikawa, O. Nishii, T.
Yano, Y. Taketani and Y. Nakamura: Genome-wide cDNA microarray analysis of
gene-expression profiles involved in ovarian endometriosis. International Journal of Oncology,
22:551-560, 2003
A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y.
Nakamura: Catalog of 668 SNPs detected among 31 genes encoding potential drug targets on
the cell surface. Journal of Human Genetics, 48:23-46, 2003
M. Unoki, and Y. Nakamura: EGR2 induces apoptosis in various cancer-cell lines by direct
transactivation of BNIP3L and BAK. Oncogene, 22:2172-2185, 2003
K. Ochi, A. Saito-Hisaminato, Y. Daigo, T. Katagiri, Y. Toyama, H. Matsumoto and Y. Nakamura:
Expression profiles of two types of human knee-joint cartilage. Journal of Human Genetics,
48:177-182, 2003
C. Tanikawa, K. Matsuda, S. Fukuda, Y. Nakamura, and H. Arakawa: p53RDL1 regulates
p53-dependent apoptosis. Nature Cell Biology, 5:216-223, 2003
G. Watanabe, H. Nishimori, H. Irifune, Y. Sasaki, S. Ishida, H. Zenbutsu, T. tanaka, S. Kawaguchi,
T. Wada, J. hata, M. Kusakabe, K. Yoshida, Y. Nakamura, and T. Tokino: Induction of
Tenascin-C by tumor-specific EWS-ETS fusion genes. Genes Chromosomes and Cancer,
36:224-232, 2003
M. Unoki, J. Okutsu, and Y. Nakamura: Identification of a novel human gene, ZFP91, involved in
acute myelogenous leukemia. International Journal of Oncology, 22:1217-1223, 2003
A. Yamada, T. Miyazaki, L-M. Lu, M. Ono, M. T. Ito, M. Terada, S. Mori, K. Hata, Y. Nozaki, S.
Nakatsuru, Y. Nakamura, M. Onji, and M. Nose: Genetic basis of tissue specificity of vasculitis in
MRL/lpr mics. Arthritis & Rheumatism, 48:1445-1451, 2003
S. Saito, A. Iida, A. Sekine, S. Kawagichi, S. Higuchi, C. Ogawa, and Y. Nakamura: Catalog of
680 variations among 8 cytochrome P450 (CYP) genes, nine esterase genes, and two other
genes in the Japanese population. Journal of Human Genetics, 48:249-270, 2003
R. Ohno, and Y. Nakamura: Prediction of response to Imatinib by cDNA microarray analysis.
Seminars in Hematology, 40:42-49, 2003
S. Kakiuchi, Y. Daigo, T. Tsunoda, S. Yano, S. Sone, and Y. Nakamura: Genome-wide analysis
of organ-preferential metastasis of human small cell lung cancer in mice. Molecular Cancer
Research, 1:485-499, 2003
H. Zembutsu, Y. Ohnishi, Y. Daigo, T. Katagiri, T. Kikuchi, S. Kakiuchi, K. Hirata and Y.
Nakamura: Gene-Expression profiles of human tumor xenografts in nude mice treated orally with
the EGFR tyrosine kinase inhibitor ZD1839. International Journal of Oncology, 23:29-39, 2003
737. W. Obara, A. Iida, Y. Suzuki, T. Tanaka, F. Akiyama, S Maeda, Y Ohnishi, R. Yamada, A. Sekine,
T. Tsunoda, T. Takei, K. Ito, K. Honda, K. Uchida, K. Tsuchiya, W. Yumura, T. Ujiie, Y. Nagane, K.
Nitta, S. Miyano, I. Narita, F. Gejyo, H. Nihei, T. Fujioka, and Y. Nakamura: Association of
single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with
Immunoglobulin A nephropathy (IgAN) in Japanese patients. Journal of Human Genetics,
48:293-299, 2003
738. H. Okabe, S. Satoh, Y. Furukawa, T. Kato, S. Hasegawa, Y. Nakajima, Y. Yamaoka, and Y.
Nakamura: Involvement of PEG10 in human hepatocellular carcinogenesis through interaction
with SIAH1. Cancer Research, 63:3043-3048, 2003
739. S. Takeda, M. Kondo, J.Sasaki, H. Kurahashi, H. Kano, K. Arai, K. Misaki, T. Fukui, K. Kobayashi,
M. Tachikawa, M. Imamura, Y. Nakamura, T. Shimizu, T. Murakami, Y. Sunada. T. Fujikado, K.
Matsumura, T. Terashima and T. Toda: Fukutin is required for maintenance of muscle integrity,
cortical histiogenesis and normal eye development. Human Molecular Genetics, 12:1449-1459,
2003
740. C.-C. Ng, H. Arakawa, S. Fukuda, H. Kondoh, and Y. Nakamura: p53RFP, a p53-inducible
RING-finger protein, regulates the stability of p21WAF1. Oncogene, 22:4449-4458, 2003
741. T. Kimura, M. Gotoh, Y. Nakamura and H. Arakawa: hCDC4b, a regulator of Cyclin E, as a direct
transcriptional target of p53. Cancer Science, 94:431-436, 2003
742. Y. Kaneta, Y. Kagami, T. Tsunoda, R. Ohno, Y. Nakamura, and T. Katagiri: Genome-wide
analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarray.
International Journal of Oncology, 23:681-691, 2003
743. A. Iida, and Y. Nakamura: Japanese Efforts in Pharmacogenomics. Current Pharmacogenomics,
1:203-215, 2003
744. K. Okada, T. Katagiri, T. Tsunoda, Y. Mizutani, Y. Suzuki, M. Kamada, T. Fujioka, T. Shuin, T.
Miki, and Y. Nakamura: Analysis of gene-expression profiles in testicular seminomas using a
genome-wide cDNA microarray. International Journal of Oncology, 23:1615-1635, 2003
745. K. Ueda, H. Arakawa and Y. Nakamura: Dual-Specificity Phosphatase 5 (DUSP5) as a direct
transcriptional target of tumor suppressor p53. Oncogene, 22:5586-5591, 2003
746. T. Nakatsura, Y. Yoshitake, S. Senju, M. Monji, H. Komori, Y. Motomura, S. Hosaka, T. Beppu, T.
Ishiko, H. Kamohara, H. Ashihara, T. Katagiri, Y. Furukawa, S. Fujiyama, M. Ogawa, Y.
Nakamura, and Y. Nishimura: Glypican-3, over-expressed specifically in human hepatocellular
carcinoma, is a novel tumor marker. Biochemical and Biophysical Research Communications,
306:16-25, 2003
747. A. Iida, K. Ozaki, Y. Ohnishi, T. Tanaka and Y. Nakamura: Identification of 46 novel SNPs in the
130-kb region containing a myocardial infarction susceptibility gene on chromosomal band 6p21.
748. T. Shimokawa, Y. Furukawa, M. Sakai, M. Li, N. Miwa, Y.-M. Lin and Y. Nakamura: Involvement
of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the
β-catenin/T-cell factor complex. Cancer Research, 63:6116-6120, 2003
749. A. Suzuki, R. Yamada, X. Chang, S.Tokuhiro, T. Sawada, M. Suzuki, M. Nagasaki, M.
Nakayama-Hamada, R.Kawaida, M. Ono, M. Ohtsuki, H. Furukawa, S. Yoshino, M. Yukioka, S.
Touma, T. Matsubara, S. Wakitani, R. Teshima, A. Sekine, A.Iida, A. Takahashi, T. Tsunoda, Y.
Nakamura, and K. Yamamoto: Functional haplotypes of PADI4, encoding citrullinating enzyme
peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nature Genetics,
34:395-402, 2003
750. T. Kimura, S. Takeda, Y. Sagiya, M. Gotoh, Y. Nakamura and H. Arakawa: Impaired function of
p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nature
Genetics, 34:440-445, 2003
751. S. Saito, A. Iida, A. Sekine, S. Kawauchi, S. Higuchi, C. Ogawa, and Y. Nakamura: Catalog of
178 variations in the Japanese population among eight human genes encoding G protein-coupled
receptors (GPCRs). Journal of Human Genetics, 48:461-468, 2003
752. N. Tanaka, T. Babazono, S. Saito, A. Sekine, T. Tsunoda, M. Haneda, Y. Tanaka, T. Fujioka, K.
Kaku, R. Kawamori, R. Kikkawa, Y. Iwamoto, Y. Nakamura and S. Maeda: Associationof solute
carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by
genome-wide analyses of Single Nucleotide Polymorphisms. Diabetes, 52:2848-2853, 2003
753. C. Suzuki, Y. Daigo, T. Kikuchi, T. Katagiri and Y. Nakamura: Identification of COX17 as a
therapeutic target for non-small cell lung cancer. Cancer Research, 63:7038-7041, 2003
754. S. Abe, S. Usami, and Y. Nakamura: Mutations in the gene encoding KIAA1199 protein, an
inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic
hearing loss. Journal of Human Genetics, 48:564-570, 2003
755. M. Unoki, and Y. Nakamura: Methylation at CpG islands in intron1 of EGR2 confers enhancer-like
activity. FEBS letters, 554:67-72, 2003
756. S. Tokuhiro, R. Yamada, X. Chang, A. Suzuki, Y. Kochi, T. Sawada, M. Suzuki, M. Nagasaki, M.
Ohtsuki, M. Ono, H. Furukawa, M. Nagashima, S. Yoshino, A. Mabuchi, A. Sekine, S. Saito, A.
Takahashi, T. Tsunoda, Y. Nakamura and K. Yamamoto: An intronic SNP in a RUNX1 binding
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site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
The International HapMap Consortium: The International HapMap Project. Nature, 426:789-796,
2003
Y. Koshizuka, T. Yamada, K. Hoshi, T. Ogasawara, U. Chung, H. Kawano, Y. Nakamura, K.
Nakamura, S. Ikegawa, H. Kawaguchi: Cystatin 10, a novel chondrocyte-specific protein, may
promote the last steps of the chondrocyte differentiation pathway. Journal of Biological
Chemistry, 278:48259-48266, 2003
S. Dan, M. Shirakawa, Y. Mukai, Y. Yoshida, K. Yamazaki, T. Kawaguchi, M. Matsuura, Y.
Nakamura, and T. Yamori: Identification of Candidate predictive markers of anticancer drug
sensitivity using a panel of human cancer cell lines. Cancer Science, 94:1074-1082, 2003
Y. Sasaki, H. Mita, M. Toyota, S. Ishida, I. Morimoto, T. Yamashita, T. Tanaka, K. Imai, Y.
Nakamura, and T. Tokino: Identification of the interleukin 4 receptor α gene as a direct target for
p73. Cancer Research, 63:8145-8152, 2003
H. Peeters, P. Debeer, A. Bairoch, V. Wilquet, C. Huysmans, E. Parthoens, J.P. Fryns, M.
Gewillig, Y. Nakamura, N. Niikawa, W. Van de Ven, and K. Devriendt: PA26 is a candidate gene
for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.
Human Genetics, 112:573-580, 2003
H. Okabe, Y. Furukawa, T. Kato, S. Hasegawa, Y. Yamaoka, and Y. Nakamura: Isolation of
development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for
hepatocellular carcinomas. International Journal of Oncology, 24:43-48, 2004
Y. Anazawa, H.Arakawa, H. Nakagawa, and Y. Nakamura: Identification of STAG1 as a key
mediator of a p53-dependent apoptotic pathway. Oncogene, 23:7621-7627, 2004
K. Yoshida, M. Monden, Y. Nakamura and H. Arakawa: Adenovirus-mediated p53AIP1 gene
transfer as a new strategy for treatment of p53-resistant tumors. Cancer Science, 95:91-97, 2004
M. Li, Y.-M. Lin, S. Hasegawa, T. Shimokawa, K. Murata, M. Kameyama, O. Ishikawa, T. Katagiri,
T. Tsunoda, Y. Nakamura and Y. Furukawa: Genes associated with liver metastasis of colon
cancer, identified by genome-wide cDNA microarray. International Journal of Oncology,
24:305-312, 2004
S. Nagayama, M. Iiizumi, T. Katagiri, J. Toguchida and Y. Nakamura: Identification of PDZK4, a
novel human gene with PDZ domains, that is up-regulated in synovial sarcomas. Oncogene,
23:5551-5557, 2004
K. Ochi, Y. Daigo, T. Katagiri, S. Nagayama, T. Tsunoda, A. Myoui, N. Naka, N. Araki, I.
Kudawara, M. Ieguchi, Y. Toyama, J. Toguchida, H. Yoshikawa and Y. Nakamura: Prediction of
response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles.
Y. Nakamura: Isolation of p53-target genes and their functional analysis (review). Cancer Science,
95:7-11, 2004
T. Sekiya, S. Adachi, K. Kohu, T. Yamada, O. Higuchi, Y. Furukawa, Y. Nakamura, T. Nakamura,
K. Tashiro, S. Kuhara, S. Ohwada, and T. Akiyama: Identification of BAP, an inhibitor of TGF-β
signaling, as a target of the β-catenin pathway in colorectal tumor cells. Journal of Biological
Chemistry, 279:6840-6846, 2004
M. Doi, A. Nagano, and Y. Nakamura: Molecular cloning and characterization of a novel gene,
EMILIN-5, and its possible Involvement in skeletal development. Biochemical and Biophysical
Research Communications, 313:888-893, 2004
K. Yoon, Y. Nakamura and H. Arakawa: Identification of ALDH4 as a p53-inducible gene and its
protective role in cellular stresses.
T. Nakamura, Y. Furukawa, T. Tsunoda, H. Ohigashi, K. Murata, O. Ishikawa, K. Ohgaki, N.
Kashimura, M. Miyamoto, S. Hirano, S. Kondo, H. Katoh, and Y. Nakamura, and T. Katagiri:
Genome-wide cDNA microarray analysis of gene-expression profiles in pancreatic cancers Using
populations of tumor cells and normal ductal epithelial cells selected for purity by laser
microdissection. Oncogene, 23:2385-2400, 2004
T. Ota, Y. Suzuki, T. Nishikawa, T. Otsuki, T. Sugiyama, R. Irie, A. Wakamatsu, K. Hayashi, H.
Sato, K. Nagai, K. Kimura, H. Makita, M. Sekine, M. Obayashi, T. Nishi, T. Shibahara, T. Tanaka,
S. Ishii, J. Yamamoto, K. Saito, Y. Kawai, Y. Isono, Y. Nakamura, K. Nagahari, K. Murakami, T.
Yasuda, T. Iwayanagi, M. Wagatsuma, A. Shiratori, H. Sudo, T. Hosoiri, Y. Kaku, H. Kodaira, H.
Kondo, M. Sugawara, M. Takahashi, K. Kanda, T. Yokoi, T. Furuya, E. Kikkawa, Y. Omura, K.
Abe, K. Kamihara, N. Katsuta, K. Sato, M. Tanikawa, M. Yamazaki, K. Ninomiya, T. Ishibashi, H.
Yamashita, K. Murakawa, K. Fujimori, H. Tanai, M. Kimata, M. Watanabe, S. Hiraoka, Y. Chiba, S.
Ishida, Y. Ono, S. Takiguchi, S. Watanabe, M. Yosida, T. Hotuta, J. Kusano, K. Kanehori, A.
Takahashi-Fujii, H. Hara, T. Tanase, Y. Nomura, S. Togiya, F. Komai, R. Hara, K. Takeuchi, M.
Arita, N. Imose, K. Musashino, H. Yuuki, A. Oshima, N. Sasaki, S. Aotsuka, Y. Yoshikawa, H.
Matsunawa, T. Ichihara, N. Shiohata, S. Sano, S. Moriya, H. Momiyama, N. Satoh, S. Takami, Y.
Terashima, O. Suzuki, S. Nakagawa, A. Senoh, H. Mizoguchi, Y. Goto, F. Shimizu, H. Wakebe, H.
Hishigaki, T. Watanabe, A. Sugiyama, M. Takemoto, B. Kawakami, M. Yamazaki, K. Watanabe,
A. Kumagai, S. Itakura, Y. Fukuzumi, Y. Fujimori, M. Komiyama, H. Tashiro, A. Tanigami, T.
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Fujiwara, T. Ono, K. Yamada, Y. Fujii, K. Ozaki, M. Hirao, Y. Ohmori, A. Kawabata, T. Hikiji, N.
Kobatake, H. Inagaki, Y. Ikema, S. Okamoto, R. Okitani, T. Kawakami, S. Noguchi, T. Itoh, K.
Shigeta, T. Senba, K. Matsumura, Y. Nakajima, T. Mizuno, M. Morinaga, M. Sasaki, T. Togashi,
M. Oyama, H. Hata, M. Watanabe, T. Komatsu, J. Mizushima-Sugano, T. Satoh, Y. Shirai, Y.
Takahashi, K. Nakagawa, K. Okumura, T. Nagase, N. Nomura, H. Kikuchi, Y. Masuho, R.
Yamashita, K. Nakai, T. Yada, Y. Nakamura, O. Ohara, T. Isogai and S. Sugano: Complete
sequencing and characterization of 21,243 full-length human cDNAs. Nature Genetics, 36:40-45,
2004
A. Iida, S. Saito, A. Sekine, Y. Kataoka, W. Tabei, and Y. Nakamura: Catalog of 300 SNPs in 23
genes encoding G-protein coupled receptors. Journal of Human Genetics, 49:194-208, 2004
Y. Kochi, R. Yamada, K. Kobayashi, A. Takahashi, A. Suzuki, A. Sekine, A. Mabuchi, F. Akiyama,
T. Tsunoda, Y. Nakamura, and K. Yamamoto: Analysis of single-nucleotide polymorphisms in
Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic
shared epitope susceptibility sequences. Arthritis & Rheumatism, 50:63-71, 2004
Y. Harima, A. Togashi, K. Horikoshi, M. Imamura, M. Sougawa, S. Sawada, T. Tsunoda, Y.
Nakamura, and T. Katagiri: Prediction of outcome of advanced cervical cancer to
thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray
analysis. Int. J. of Radiation Oncology, Biology, Physics, 60:237-248, 2004
D. Yuki, Y.-M. Lin, Y. Fujii, Y. Nakamura, and Y. Furukawa: Isolation of LEMD domain containing
1, a novel testis-specific gene expressed in colorectal cancer. Oncology Reports, 12:275-280,
2004
N. Jinawath, Y. Furukawa, and Y. Nakamura: Identification of NOL8,a nucleolar protein
containing an RNA recognition motif (RRM),which was overexpressed in diffuse-type gastric
cancer. Cancer Science, 95:430-435, 2004
A. Iida, Y. Nakamura: Identification of 45 novel SNPs in the 83-kb region containing
peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. Journal of Human
Genetics, 49:387-390, 2004
K. Ozaki, K. Inoue, H. Sato, A. Iida, Y. Ohnishi, A. Sekine, H. Sato, K. Odashiro, M. Nobuyoshi, M.
Hori, Y. Nakamura, and T. Tanaka: Functional variation in LGALS2 confers risk of myocardial
infarction and regulates lymphotoxin-α secretion in vitro. Nature, 429:72-75, 2004
N. Kamatani, A. Sekine, T. Kitamoto, A. Iida, S. Saito, A. Kogame, E. Inoue, M. Kawamoto, M.
Harigai, and Y. Nakamura: Large-scale single-nucleotide polymorphism (SNP) and haplotype
analyses, using dense SNP maps, of 199 drug-related genes in 752 subjects: The analysis of the
association between uncommon SNPs within haplotype blocks and the haplotypes constructed
with haplotype-tagging SNPs. Am. J. Human Genetics, 75:190-203, 2004
A. Iida, S. Saito, A. Sekine, W. Tabei, Y. Kataoka, and Y. Nakamura: Identification of 20 novel
SNPs in the guanine nucleotide binding protein alpha 12 gene locus. Journal of Human Genetics,
49:445-448, 2004
N. Jinawath, Y. Furukawa, S. Hasegawa, M. Li, T. Tsunoda, S.Satoh, T. Yamaguchi, H. Imamura,
M.Inoue, H. Shiozaki, and Y. Nakamura:
Comparison of gene-expression profiles between
diffuse-and intestinal-type gastric cancers using a genome-wide cDNA microarray. Oncogene,
23:6830-6844, 2004
T. Tsunoda, G. M. Lathrop, A. Sekine, R. Yamada, A. Takahashi, Y. Ohnishi, T. Tanaka and Y.
Nakamura:
Variation of gene-based SNPs and linkage disequilibrium patterns in the human
genome. Human Molecular Genetics, 13:1623-1632, 2004
R. Hamamoto, Y. Furukawa, M. Morita, Y. Iimura, F. P. Silva, M. Li, R. Yagyu and Y. Nakamura:
SMYD3 encodes a novel histone methyltransferase involved in the proliferation of cancer cells.
Nature Cell Biology, 6:731-740, 2004
S. Ashida, H. Nakagawa, T. Katagiri, M. Furihata, M.Iiizumi, Y. Anazawa, T. Tsunoda, R. Takata,
K. Kasahara, T. Miki, T. Fujioka, T. Shuin, and Y. Nakamura: Molecular Features of the
Transition from Prostatic Intraepithelial Neoplasia (PIN) to Prostate Cancer: Genome-wide
Gene-expression profiles of Prostate Cancers and PINs.
Cancer Research, 64:5963-5972,
2004
T. Nishidate, T. Katagiri, M.-L Lin, Y. Mano, Y. Miki, F. Kasumi, M. Yoshimoto, T. Tsunoda, K.
Hirata, and Y. Nakamura: Genome-wide gene expression profiles of breast-cancer cells purified
with laser microbeam microdissection: Identification of genes associated with progression and
metastasis. International Journal of Oncology, 25:797-819, 2004
T. Mizuguchi, G. Collod-Beroud, T. Akiyama, M. Abifadel, N. Harada, T. Morisaki, D. Allard, M.
Varret, M. Claustres, H. Morisaki, M. Ihara, A. Kinoshita, K. Yoshiura, C. Junien, T. Kajii, G.
Jondeau, T. Ohta, T. Kishino, Y. Furukawa, Y. Nakamura, N. Niikawa, C. Boileau, and N.
Matsumoto: Heterozygous TGFBR2 mutations in Marfan syndrome. Nature Genetics, 36:855-860,
2004
M. Unoki, T. Nishidate, and Y. Nakamura: ICBP90, an E2F-1 target, recruits HDAC1 and binds
to methyl-CpG through its SRA domain. Oncogene, 23:7601-7610, 2004
P.-C. Cha, R. Yamada, A. Sekine, Y. Nakamura, C.-L. Koha: Inference from the relationships
between linkage disequilibrium and allele frequency distributions of 240 candidate SNPs in 109
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genes of drug-related genes in 4 Asian populations. Journal of Human Genetics, 49:558-572,
2004
M. Takahashi, Y.-M. Lin, Y. Nakamura, and Y. Furukawa: Isolation and characterization of a
novel gene CLUAP1 whose expression is frequently upregulated in colon cancer. Oncogene,
23:9289-9294, 2004
Y. Yoshitake, T. Nakatsura, M. Monji, S. Senju, H. Matsuyoshi, H. Tsukamoto, S. Hosaka, H.
Komori, D. Fukuma, Y. Ikuta, T. Katagiri, Y. Furukawa, H. Ito, M. Shinohara, Y. Nakamura, and Y.
Nishimura: Proliferation potential-related protein, an ideal esophageal cancer antigen for
immnotherapy, identified using complementary DNA microarray analysis.
Clinical Cancer
Research, 10:6437-6448, 2004
R. Yagyu, Y. Furukawa, Y.-M. Lin, T. Shimokawa, T. Yamamura, and Y. Nakamura: A novel
oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. International Journal of
Oncology, 25:1343-1348, 2004
M. Nishiu, Y. Tomita, S. Nakatsuka, T. Takakuwa, N. Iizuka, Y. Hoshida, J. Ikeda, K. Iuchi, R.
Yanagawa, Y. Nakamura and K. Aozasa: Distinct pattern of gene expression in
pyothorax-associated lymphoma(PAL),a lymphoma developing inlong-standing inflammation.
Cancer Science, 95:828-834, 2004
N. Ishikawa, Y. Daigo, W. Yasui, K. Inai, H. Nishimura, E. Tsuchiya, N. Kohno, and Y. Nakamura:
ADAM8 as a novel serological and histochemical marker for lung cancer. Clinical Cancer
Research, 10:8363-8370, 2004
K. Okada, E. Hirota, Y. Mizutani, T. Fujioka, T. Shuin, T. Miki, Y. Nakamura and T. Katagiri:
Oncogenic role of NALP7 in testicular seminomas. Cancer Science, 95:949-954, 2004
K. Yamazaki, M. Takazoe, T. Tanaka, T. Ichimori, S. Saito, A. Iida, Y. Onouchi, A. Hata and Y.
Nakamura: Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with
Crohn disease. Journal of Human Genetics, 49:664-668, 2004
T. Minaguchi, H. Yoshikawa, S. Nakagawa, T. Yasugi, T. Yano, H. Iwase, K. Mizutani, K.
Shiromizu, K. Ohmi, Y. Watanabe, K. noda, M. Nishiu, Y. Nakamura, Y. Taketani: Association of
PTEN mutation with HPV-negative adenocarcinoma of the uterine cervix. Cancer Letters,
210:57-62, 2004
T.Nakatsura, H. Komori, T. Kudo, Y. Yoshitake, S. Senju, T. Katagiri, Y. Furukawa, M. Ogawa, Y.
Nakamura and Y. Nishimura: Mouse homologue of a novel human oncofetal antigen, Glypican-3,
evokes T- cell-mediated tumor rejection without autoimmune reactions in mice. Clinical Cancer
Research, 10:8630-8640, 2004
N. Uchida, T. Tsunoda, S. Wada, Y. Furukawa, Y. Nakamura, H. Tahara: Ring finger protein 43
as a new target for cancer immunotherapy. Clinical Cancer Research, 10:8577-8586, 2004
S. Kakiuchi, Y. Daigo, N. Ishikawa, C. Furukawa, T. Tsunoda, S. Yano, K. Nakagawa, T. Tsuruo,
N. Kohno, M. Fukuoka, S. Sone, and Y. Nakamura: Prediction of sensitivity of advanced
non-small cell lung cancers to gefitinib （ Iressa,ZD1839). Human Molecular Genetics,
13:3029-3043, 2004
H. Kamiyama, K. Kurosaki, M. Kurimoto, T. Katagiri, Y. Nakamura, M. Kurokawa, H. Sato, S.
Endo and K. Shiraki: Herpes simplex virus induced death receptor-dependent apoptosis and
regression of transplanted human cancers. Cancer Science, 95:990-998, 2004
Y. Onouchi, S. Onoue, M. Tamari, K. Wakui, Y. Fukushima, M. Yashiro, Y. Nakamura, H.
Yanagawa, F. Kishi, K. Ouchi, M. Terai, K. Hamamoto, F. Kudo, H. Aotsuka, Y. Sato, A. Nariai, Y.
Kaburagi, M. Miura, T. Saji, T. Kawasaki, Y. Nakamura, and A. Hata: CD40 ligand gene and
Kawasaki disease. Eur. J. Human Genetics, 12:1062-1068, 2004
T. Hirota, K. Obara, A. Matsuda, M. Akahoshi, K. Nakashima, K. Hasegawa, N. Takahashi, M.
Shimizu, H. Sekiguchi, M. Kokubo, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, T. Enomoto, F.
Kishi, Y. Suzuki, H. Saito, Y. Nakamura, T. Shirakawa, and M. Tamari: Association between
genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. Journal
of Human Genetics, 49:370-375, 2004
A. Kanazawa, S. Tsukada, A. Sekine, T. Tsunoda, A. Takahashi, A. Kashiwagi, Y. Tanaka, T.
Babazono, M. Matsuda, K. Kaku, Y. Iwamoto, R. Kawamori, R. Kikkawa, Y. Nakamura, and S.
Maeda; Association of the gene encoding wingless-type mammary tumor virus integration-site
family member 5B (WNT5B) with type 2 diabetes. Am. J. Human Genetics, 75:832-843, 2004
M. Onda, M. Emi, H. Nagai, T. Nagahata, K. Tsumagari, T. Fujimoto, F. Akiyama, G. Sakamoto,
M. Makita, F. Kasumi, Y. Miki, T. Tanaka, T. Tsunoda, and Y. Nakamura: Gene expression
patterns as marker for 5-year postoperative prognosis of primary breast cancers. J Cancer Res
Clin Oncol,, 130:537-545, 2004
P. Graff, J. Seim, O. Amellem, H. Arakawa, Y. Nakamura, K. K. Andersson, T. Stokke and E. O.
Pettersen: pRb protection by RNR counteraction of pRb-dependent protection after extreme
hypoxia by elevated ribonucleotide reductase. Cell Prolif., 37:367-383, 2004
A. Niida, T. Hiroko, M. Kasai, Y. Furukawa, Y. Nakamura, Y. Suzuki, S. Sugano and T. Akiyama:
DKK1, a negative regulator of Wnt signaling, is a target of the b-catenin/TCF pathway. Oncogene,
23:8520-8526, 2004
S. Ohtsubo, A. Iida, K. Nitta, T. Tanaka, R. Yamada, Y. Ohnishi, S. Maeda, T. Tsunoda, T. Takei,
810.
811.
812.
813.
814.
815.
816.
817.
818.
819.
820.
821.
822.
823.
824.
825.
826.
827.
W. Obara, F. Akiyama, K. Ito, K. Honda, K. Uchida, K. Tsuchiya, W. Yumura, T. Ujiie, Y. Nagane,
S. Miyano, Y. Suzuki, I. Narita, F. Gejyo, T. Fujioka, H. Nihei and Y. Nakamura: Association of a
single-nucleotide polymorphism in the immunoglobulin u-binding protein 2 gene with
immunoglobulin A nephropathy. Journal of Human Genetics, 50:30-35, 2005
F. P. Silva, R. Hamamoto, Y. Nakamura, and Y. Furukawa: WDRPUH, a novel
WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and
involved in cell proliferation. Neoplasia, 7:348-355, 2005
A. Iida, K. Ozaki, T. Tanaka, and Y. Nakamura: Fine-scale SNP map of an 11-kb genomic region
at 22q13.1 containing the galectin-1 gene. Journal of Human Genetics, 50:42-45, 2005
W.-R. Park, Y. Nakamura: a novel p53-inducible gene involved in the p53-dependent cell-survival
pathway. Cancer Research, 65:1197-1206, 2005
K. Taniuchi, H. Nakagawa, M.Hosokawa, T. Nakamura, H. Eguchi, H. Ohigashi, O. Ishikawa, T.
Katagiri, and Y. Nakamura: Overexpressed P-cadherin/CDH3 promotes motility of pancreatic
cancer cells by interacting with p120ctn and activating Rho-family GTPases. Cancer Research,
65:3092-3099, 2005
R. Takata, T. Katagiri, M. Kanehira, T. Tsunoda, T. Shuin, T. Miki, M. Namiki, K. Kohri, Y.
Matsushita, T. Fujioka and Y. Nakamura: Predicting response to methotrexate, vinblastine,
doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide
gene expression profiling. Clinical Cancer Research, 11:2625-2636, 2005
H. Kizawa, I. Kou, A. Iida, A. Sudo, Y. Miyamoto, A. Fukuda, A. Mabuchi, A. Kotani, A. Kawakami,
S. Yamamoto, N. Uchida, K. Nakamura, K. Notoya, Y. Nakamura and S. Ikegawa: An aspartic
acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to
osteoarthritis. Nature Genetics, 37:138-144, 2005
L. Yang, A. C. C. Leung, J. M. Y. Ko, P. H. Y. Lo, J. C. O. Tang, G. Srivastava, M. Oshimura, E. J.
Stanbridge, Y. Daigo, Y. Nakamura, C. M. C. Tang, K. W. Lau, S. Law and M. L. Lung: Tumor
suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell
carcinoma. Oncogene, 24:697-705, 2005
K.Taniuchi, H. Nakagawa, T. Nakamura, H. Eguchi, H. Ohigashi, O. Ishikawa, T. Katagiri, and Y.
Nakamura: Down-regulation of RAB6KIFL / KIF20A, a kinesin involved with membrane trafficking
of discs large homolog 5, can attenuate growth of pancreatic cancer cells. Cancer Research,
65:105-112, 2005
A. Iida, Y. Nakamura: Identification of 156 novel SNPs in 29 genes encoding G-protein coupled
receptors. Journal of Human Genetics, 50:182-191, 2005
Y. Anazawa, H. Nakagawa, M. Furihara, S. Ashida, K. Tamura, H. Yoshioka, T. Shuin, T. Fujioka,
T. Katagiri, and Y. Nakamura: PCOTH, a novel gene over-expressed in prostate cancers,
promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ib/SET.
A. Togashi, T. Katagiri, S. Ashida, T. Fujioka, O. Maruyama, Y. Wakumoto, Y. Sakamoto, M.
Fujime, Y. Kawachi, T. Shuin and Y. Nakamura: Hypoxia-inducible protein 2 (HIG2), a novel
diagnostic marker for renal cell carcinoma and potential target for molecular therapy. Cancer
Research, 65:4817-4826, 2005
S. Nagayama, C. Fukukawa, T. Katagiri, T. Okamoto, T. Aoyama, N. Oyaizu, M. Imamura, J.
Toguchida and Y. Nakamura: Therapeutic potential of antibodies against FZD10, a cell-surface
protein, for synovial sarcomas. Oncogene, 24:6201-6212, 2005
H. Mototani, A. Manuchi, S. Saito, M. Fujioka, A. Iida, Y. Takatori, A. Kotani, T. Kubo, K.
Nakamura, A. Sekine, Y. Murakami, T. Tsunoda, K. Notoya, Y. Nakamura and S. Ikegawa: A
functional single nucleotide polymorphism in the core promoter region of CALM1 is associated
with hip osteoarthritis in Japanese. Human Molecular Genetics, 14:1009-1017, 2005
K. Obama, K. Ura, M. Li, T. Katagiri, T. Tsunoda, A. Nomura, S. Satoh, Y. Nakamura, and Y.
Furukawa: Genome-wide analysis of gene expression in human intrahepatic
cholangiocarcinomas. Hepatology, 41:1339-1348, 2005
K. Obama, K. Ura, S. Satoh, Y. Nakamura, and Y. Furukawa: Up-regulation of PSF2, a member
of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma. Oncology Reports,
14:701-706, 2005
T. Watanabe, T. Suda, T. Tsunoda, N. Uchida, K. Ura, T. Kato, S. Hasegawa, S. Satoh, S. Ohgi,
H. Tahara, Y. Furukawa and Y. Nakamura: Identification of Immunoglobulin superfamily 11
(IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular
carcinomas. Cancer Science, 96:498-506, 2005
S. Maeda, S. Tsukada, A. Kanazawa, A. Sekine, T. Tsunoda, D. Koya, H. Maegawa, A.
Kashiwagi, T. Babazono, M. Matsuda, Y. Tanaka, T. Fujioka, H. Hirose, T. Eguchi, Y. Ohno, C.
Groves, A. Hattersley, G. Hitman, M. Walker, K. Kaku, Y. Iwamoto, R. Kawamori, R. Kikkawa, N.
Kamatani, M. McCarthy, and Y. Nakamura: Genetic Variations in the gene encoding TFAP2B
are associated with type 2 diabetes mellitus. Journal of Human Genetics, 50:283-292, 2005
S.Shimazaki, Y. Kawamura, A. Kanazawa, A. Sekine, S. Saito, T. Tsunoda, D. Koya, T.
Babazono, Y. Tanaka, M. Matsuda, K. Kawai, T. Iiizumi, M. Imanishi, T. Shinosaki, T. Yanagimoto,
M. Ikeda, S. Omachi, A. Kashiwagi, K. Kaku, Y. Iwamoto, R. Kawamori, R. Kikkawa, M. Nakajima,
828.
829.
830.
831.
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833.
834.
835.
836.
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839.
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842.
843.
844.
845.
Y. Nakamura, and S. Maeda: Genetic variations in the gene encoding ELMO1 are associated with
susceptibility to diabetic nephropathy. Diabetes, 54:1171-1178, 2005
M. Akahoshi, K. Obara, T. Hirota, A. Matsuda, K. Hasegawa, N. Takahashi, M. Shimizu, K.
Nakashima, L. Cheng, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, N. Higashi, M. Taniguchi, T.
Enomoto, X.Q. Mao, H. Nakashima, C.N. Adra, Y. Nakamura, M. Tamari, and T. Shirakawa :
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.
T. Kato, Y. Daigo, S. Hayama, N. Ishikawa, T. Yamabuki, T. Ito, M. Miyamoto, S. Kondo and Y.
Nakamura: A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis.
K. Asamura, S. Abe, Y. Imamura, A. Aszodi, N. Suzuki, S. Hashimoto, Y. Takumi, T. Hayashi, R.
Fassler, Y. Nakamura, and S. Usami: Type IX collagen is crucial for normal hearing.
Neuroscience, 132:493-500, 2005
R. Kawaida, R. Yamada, K. Kobayashi, S. Tokuhiro, A. Suzuki, Y Kochi, X. Chang, A. Sekine, T.
Tsunoda, T. Sawada, H. Furukawa, Y. Nakamura, and K. Yamamoto: CUL1, a component of E3
ubiquitin ligase, alters lymphocyte signal transduction with possible effect on rheumatoid arthritis.
Genes Immun, 6:194-202, 2005
S. Seki, Y. Kawaguchi, K. Chiba, Y. Mikami, H. Kizawa, T. Oya, F. Mio, M. Mori, Y. Miyamoto, I.
Masuda, T. Tsunoda, M. Kamata, T. Kubo, Y. Toyama, T. Kimura, Y. Nakamura and S. Ikegawa:
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with
susceptibility to lumbar disc disease. Nature Genetics, 37:607-612, 2005
Y. Kochi, R. Yamada, A. Suzuki, J. B. Harley, S. Shirasawa, T. Sawada, S. C. Bae, S. Tokuhiro, X.
Chang, A. Sekine, A. Takahashi, T. Tsunoda, Y. Ohnishi, K. M. Kaufman, C. P. Kang, C. Kang, S.
Otsubo, W. Yumura, A. Mimori, T. Koike, Y. Nakamura, T. Sasazuki and K. Yamamoto: A
functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis
and several autoimmunities. Nature Genetics, 37:478-485, 2005
C. Furukawa, Y. Daigo, N. Ishikawa, T. Kato, T. Ito, E. Tsuchiya, S. Sone, and Y. Nakamura:
Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer
Research, 65:7102-7110, 2005
M. Tsuge, R. Hamamoto, F. P. Silva, Y. Ohnishi, K. Chayama, N. Kamatani, Y. Furukawa, and Y.
Nakamura: A variable number of tandem repeats polymorphism in an E2F-1 binding element in
the 5' flanking region of SMYD3 is a risk factor for human cancers. Nature Genetics,
37:1104-1107, 2005
M. Takahashi, Y. Nakamura, K. Obama, and Y. Furukawa: Identification of SP5 as a
downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon
cancer. International Journal of Oncology, 27:1483-1487, 2005
N. Ishikawa, Y. Daigo, A. Takano, M. Taniwaki, T. Kato, S. Hayama, H. Murakami, Y. Takeshima,
K. Inai, H. Nishimura, E. Tsuchiya, N. Kohno, and Y. Nakamura: Increases of amphiregulin and
transforming growth factor-α in serum as predictors of poor response to Gefitinib among patients
with advanced non-small cell lung cancers. Cancer Research, 65:9176-9184, 2005
C. Suzuki, Y. Daigo, N. Ishikawa, T. Kato, S. Hayama, T. Ito, E. Tsuchiya, and Y. Nakamura:
ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by
involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Research, 65:11314-11325,
2005
K. Asamura, S. Abe, H. Fukuoka, Y. Nakamura, and S. Usami: Mutation analysis of COL9A3, a
gene highly expressed in the cochlea, in hearing loss patients. Auris Nasus Larynx, 32:113-117,
2005
A. Kanazawa, Y. Kawamura, A. Sekine,A. Iida,T. Tsunoda,A. Kashiwagi,Y. Tanaka,T.
Babazono,M. Matsuda,K. Kawai,T. Iiizumi,T. Fujioka,M. Imanishi,K. Kaku,Y. Iwamoto,R.
Kawamori,R. Kikkawa,Y. Nakamura, and S.Maeda: Single nucleotide polymorphosms in the gene
encoding Kruppel-like factor 7 are associated with type 2diabetes. Diabetologia, 48:1315-1322,
2005
C. Fukukawa, Y. Nakamura and T. Katagiri: Molecular target therapy for synovial sarcoma.
Future Oncology, 1:805-812, 2005
T. Watanabe, M. Suzuki,Y. Yamasaki,S. Okuno,H. Hishigaki,T. Ono,K. Oga,A.
Mizoguchi-Miyakita,A. Tsuji,N. Kanemoto,S. Wakitani,T. Takagi,Y. Nakamura, and A. Tanigami:
Mutated
G-protein-coupled
receptor
GPR10
is
responsible
for
the
hyperphagia/dyslipidaemia/obesity locus of Dmol in the OLETD rat. Clinical and Experimental
Pharmacology and Physiology, 32:355-366, 2005
K. Yamazaki, D. McGovern, J. Ragoussis, M. Paolucci, H. Butler, D. Jewell, L. Cardon, M.
Takazoe, T. Tanaka, T. Ichimori, S. Saito, A. Sekine, A. Iida, A. Takahashi, T. Tsunoda, M.
Lathrop and Y. Nakamura: Single nucleotide polymorphisms in TNFSF15 confer susceptibility to
Crohn's disease. Human Molecular Genetics, 14:3499-3506, 2005
The International HapMap Consortium: A haplotype map of the human genome. Nature,
437:1299-1320, 2005
T. Ishibe, T. Nakayama, T. Okamoto, T. Aoyama, K. Nishijo, K. Shibata, Y. Shima, S. Nagayama,
846.
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848.
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853.
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863.
T. Katagiri, Y. Nakamura, T. Nakamura, and J. Toguchida: Disruption of fibroblast growth factor
signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitor to
molecular target therapy. Clinical Cancer Research, 11:2702-2712, 2005
T. Hirota, Y. Suzuki, K. Hasegawa, K. Obara, A. Matsuda, M. Akahoshi, K. Nakashima, L. Cheng,
N. Takahashi, M. Shimizu, S. Doi, K. Fujita, T. Enomoto, M. Ebiwsawa, S. Yoshihara, Y.
Nakamura, F. Kishi, T. Shirakawa, and M. Tamari: Functional haplotypes of IL-12B are
associated with childhood atopic asthma. J Allergy Clin Immunol, 116:789-795, 2005
A. Matsuda, T. Hirota, M. Akahoshi, M. Shimizu, M. Tamari, A. Miyatake, A. Takahashi, K.
Nakashima, N. Takahashi, K. Obara, N.Yuyama, S. Doi, Y. Kamogowa, T. Enomoto, K. Ohshima,
T. Tsunoda, S. Miyatake, K. Fujita, M. Kusakabe, K. Izuhara, Y. Nakamura, J. Hopkin, and
T.Shirakawa: Coding SNP in tenascin-C Fn-Ⅲ-D domain associates with adult asthma. Human
T. Mushiroda, S. Saito, Y. Tanaka, J. Takasaki, N. Kamatani, Y. Beck, H. Tahara, Y. Nakamura,
and Y. Ohnishi: A model of prediction system for adverse cardiovascular reactions by calcineurin
inhibitors among patients with renal transplants using gene-based single-nucleotide
polymorphisms. Journal of Human Genetics, 50:442-447, 2005
T. Miyazaki, M. Ono, W.-M. Qu, M.-C. Zhang, S. Mori, S. Nakatsuru, Y. Nakamura, T. Sawasaki,
Y. Endo and M. Nose: Implication of allelic polymorphism of osteopontin in the development of
lupus nephritis in MRL/lpr mice. Eur. J. Immunol., 35:1510–1520, 2005
Y. Sasaki, Y. Naishiro, Y. Oshima, K. Imai, Y. Nakamura and T. Tokino: Identification of pigment
epithelium-derived factor as a direct target of the p53 family member genes. Oncogene,
24:5131–5136, 2005
M. Sakai, T. Shimokawa, T. Kobayashi, S. Matsushima, Y. Yamada, Y. Nakamura, and Y.
Furukawa: Elevated expression of C10orf3 (chromosome 10 open reading frame 3) is involved
in the growth of human colon tumor. Oncogene, 25:480-486, 2006
R. Hamamoto, F. P. Silva, M. Tsuge, T. Nishidate, T. Katagiri, Y. Nakamura and Y. Furukawa:
Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Science,
97:113-118, 2006
K. Obama, T. Kato, S. Hasegawa, S. Satoh, Y. Nakamura, and Y. Furukawa: Overexpression of
peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells. Clinical
A. Iida, S. Saito, A. Sekine, A. Takahashi, N. Kamatani, and Y. Nakamura: Japanese single
nucleotide polymorphism database for 267 possible drug-related genes. Cancer Science,
97:16-24, 2006
T. Kikuchi, Y. Daigo, N. Ishikawa, T. Katagiri, T. Tsunoda, S. Yoshida, and Y. Nakamura:
Expression profiles of metastatic brain tumor from lung adenocarcinomas on cDNA microarray.
T. Mushiroda, Y. Ohnishi, S. Saito, A. Takahashi, Y. Kikuchi, S. Saito, H. Shimomura, Y.
Wanibuchi, T. Suzuki, N. Kamatani, and Y. Nakamura: Association of VKORC1 and CYP2C9
polymorphisms with warfarin dose requirements in Japanese patients. Journal of Human
Genetics, 51:249-253, 2006
T. Suda, T. Tsunoda, N. Uchida, T. Watanabe, S. Hasegawa, S. Satoh, S. Ohgi, Y. Furukawa, Y.
Nakamura, and H. Tahara: Identification of secernin 1 as a novel immunotherapy target for
gastric cancer using the expression profiles of cDNA microarray. Cancer Science, 97:411-419,
2006
K. Yoshiura, A. Kinoshita, T. Ishida, A. Ninokata,T. Ishikawa, T. Kaname, M. Bannai, K. Tokunaga,
S. Sonoda, R. Komaki, M. Ihara, V. Saenko, A. G. Kaimovich, I. Sekine, K. Komatsu, H.
Takahashi, M. Nakashima, N. Sosonkina, C. K. Mapendano, M. Ghadami, M. Nomura, D.-S.
Linag, D.-K. Kim, A. Garidkhuu, N. Natsume, T. Ohta, H. Tomita, K. Hirayama, M. Ishibashi, A.
Takahashi, N. Saito, S. Saitou, Y. Nakamura, and N, Niikawa: A SNP in the ABCC11 gene is the
determinant of human earwax type. Nature Genetics, 38:324-330, 2006
T. Yamabuki, Y. Daigo, T. Kato, S. Hayama, T. Tsunoda, M. Miyamoto, T. Ito, M. Fujita, M.
Hosokawa, S. Kondo, and Y. Nakamura: Genome-wide gene expression profile analysis of
esophageal squamous cell carcinomas. International Journal of Oncology, 28:1375-1384, 2006
A. Iida, H. Kizawa, Y. Nakamura, and S. Ikegawa: High-resolution SNP map of ASPN, a
susceptibility gene for osteoarthritis. Journal of Human Genetics, 51:151-154, 2006
F. P. Silva, R. Hamamoto, Y. Furukawa, and Y. Nakamura: TIPUH1 encodes a novel KRAB
zinc-finger protein highly expressed in human hepatocellular carcinomas. Oncogene,
25:5063-5070, 2006
K. Nakashima, T. Hirota, Y. Suzuki, A. Matsuda, M. Akahoshi, M. Shimizu, A. Jodo, S. Doi, K.
Fujita, M. Ebisawa, S. Yoshihara,T. Enomoto, T. Shirakawa, F. Kishi, Y. Nakamura, and M.
Tamari: Association of the RIP2 gene with childhood atopic asthma. Allergology International,
1:77-83, 2006
K. Nakashima, T. Hirota, K. Obara, M. Shimizu, A. Jodo, M. Kameda, S. Doi, K. Fujita, T.
Shirakawa, T. Enomoto, F. Kishi, S. Yoshihara, K. Matsumoto, H. Saito, Y. Suzuki, Y.Nakamura,
and M. Tamari: An association study of asthma and related phenotypes with polymorphisms in
864.
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868.
869.
870.
871.
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877.
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negative regulator molecules of the TLR signaling pathway. Journal of Human Genetics,
51:284-291, 2006
S. Ashida, M. Furihata, T. Katagiri, K. Tamura, Y. Anazawa, H. Yoshioka, T. Miki, T. Fujioka, T.
Shuin, Y. Nakamura, and H. Nakagawa: Expression of a novel molecules, MICAL2-PV (MICAL2
prostate cancer variants), increases with high gleason score and prostate cancer progression.
Clinical Cancer Research, 12:2767-2773, 2006
N. Ishikawa, Y. Daigo, A. Takano, M. Taniwaki, T. Kato, S. Tanaka, W. Yasui, Y. Takeshima, K.
Inai, H. Nishimura, E. Tsuchiya, N. Kohno, and Y. Nakamura: Characterization of SEZ6L2
cell-surface protein as a novel prognostic marker for lung cancer. Cancer Science, 97:737-745,
2006
T. Kobayashi, T. Masaki, M. Sugiyama, Y. Atomi, Y. Furukawa, and Y. Nakamura: A gene
encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of
human colon cancer cells. International Journal of Oncology, 29:341-347, 2006
M. Taniwaki, Y. Daigo, N. Ishikawa, A. Takano, T. Tsunoda, W. Yasui, K. Inai, N. Kohno, and Y.
Nakamura: Gene expression profiles of small-cell lung cancers: molecular signatures of lung
cancer. International Journal of Oncology, 29:567-575, 2006
E. Hirota, L. Yan, T. Tsunoda, S. Ashida, M. Fujime, T. Shuin, T. Miki, Y. Nakamura and T.
Katagiri: Genome-wide gene expression profiles of clear cell renal cell carcinoma; International
Journal of Oncology, 29:799-827, 2006
J.-H. Park, M.-l. Lin, T. Nishidate, Y. Nakamura, and T. Katagiri: PDZ-binding kinase/T-LAK
cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast
K. Ozaki, H. Sato, A. Iida, H. Mizuno, T. Nakamura, Y. Miyamoto, A. Takahashi, T. Tsunoda, S.
Ikegawa, N. Kamatani, M. Hori, Y. Nakamura, and T. Tanaka: A functional SNP in PSMA6
confers risk of myocardial infarction in the Japanese population. Nature Genetics, 38:921-925,
2006
N. Jinawath, Y. Chamgramol, Y. Furukawa, K. Obama, T. Tsunoda, B. Sripa, C. Pairojkul, and Y.
Nakamura: Comparison of gene expression profiles between opisthorchis viverrini and
non-0pisthorchis viverrini associated human intrahepatic cholangiocarcinoma. Hepatology,
44:1025-1038, 2006
Y. Nakamura, M. Futamura, H. Kamino, K. Yoshida,Y. Nakamura, and H. Arakawa: Identification
of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis. Cancer
Science, 97:633-641, 2006
A. Takehara, H. Eguchi, H. Ohigashi, O. Ishikawa, T. Kasugai, M. Hosokawa, T. Katagiri, Y.
Nakamura, and H. Nakagawa: Novel tumor marker, REG4 detected in serum of patients with
resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. Cancer Science,
97:1191-1197, 2006
M. Iiizumi, H. Nakagawa, M. Hosokawa, A. Takehara, C. Su-Youn, T. Nakamura, T. Katagiri, H.
Eguchi, H. Ohigashi, O. Ishikawa, Y. Nakamura, and H. Nakagawa: EphA4 receptor,
overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth. Cancer
Science, 97:1211-1216, 2006
K. Takahashi, C. Furukawa, A. Takano, N. Ishikawa, T. Kato, S. Hayama, C. Suzuki, W. Yasui, K.
Inai, S. Sone, T. Ito, H. Nishimura, E. Tsuchiya, Y. Nakamura and Y. Daigo: The neuromedin
u-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling
pathway as a therapeutic target for lung cancer. Cancer Research, 66:9408-9419, 2006
S. Hayama, Y. Daigo, T. Kato, N. Ishikawa, T. Yamabuki, M. Miyamoto, T. Ito, E. Tsuchiya, S.
Kondo, and Y. Nakamura: Activation of CDCA1-KNTC2, members of centromere protein
complex, involved in pulmonary carcinogenesis. Cancer Research, 66:10339-10348, 2006
K. Ura, K. Obama, S. Satoh, Y. Sakai, Y. Nakamura, and Y. Furukawa: Enhanced RASGEF1A
expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. Clinical
N. Ishii, K. Ozaki, H. Sato, H. Mizuno, S. Saito, A. Takahashi, Y. Miyamoto, S. Ikegawa, N.
Kamatani, M. Hori, S. Saito, Y. Nakamura and T. Tanaka: Identification of a novel non-coding
RNA, MIAT, that confers risk of myocardial Infarction. Journal of Human Genetics, 51:1087-1099,
2006
S. Mahasirimongkol, W. Chantratita, S. Promso, E. Pasomsab, N. Jinawath, W.
Jongjaroenprasert, V. Lulitanond, P. Krittayapoositpot, S. Tongsima, P. Sawanpanyalert, N.
Kamatani, Y. Nakamura, and T. Sura: Similarity of the allele frequency and linkage disequilibrium
pattern of single nucleotide polymorphisms in drug-related gene loci between Thai and northern
East Asian populations: implications for tagging SNP selection in Thais. Journal of Human
Genetics, 51:896-904, 2006
Y. Nakazaki, H. Hase, H. Inoue, Y.Beppu, M. Xin, G. Sakaguchi, R. Kurita, S. Asano, Y.
Nakamura, and K. Tani: Serial analysis of gene expression in progressing and regressing mouse
tumor implicates the involvement of RANTES andTARC in antitumor immune responses.
Molecular Therapy, 14:599-606, 2006
M. Kato, A. Sekine, Y. Ohnishi, T. A. Johnson, T. Tanaka, Y. Nakamura, and T. Tsunoda: Linkage
882.
883.
884.
885.
886.
887.
888.
889.
890.
891.
892.
893.
894.
895.
896.
897.
898.
899.
900.
disequilibrium of evolutionarily conserved regions in the human genome. BMC Genomics,
7:326-333, 2006
T. Hirota, K. Hasegawa, K. Obara, A. Matsuda, M. Akahoshi, K. Nakashima, T. Shirakawa, S. Doi,
K. Fujita, Y. Suzuki, Y. Nakamura and M. Tamari: Association between ADAM33 polymorphisms
and adult asthma in the Japanese population. Clinical & Experimental Allergy, 364:884-891, 2006
S. Tachiiri, T. Katagiri, T. Tsunoda, N. Oya, M. Hiraoka, and Y. Nakamura: Analysis of
gene-expression profiles after gamma irradiation of normal human fibroblasts. International
Journal of Radiation Oncology*Biology*Physics, 64:272-277, 2006
A. Shimo, T. Nishidate, T. Ohta, M. Fukuda and Y. Nakamura, and T. Katagiri: Elevated
expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells.
Cancer Science, 98:174-181, 2007
T. Kato, S. Hayama, T. Yamabuki, N. Ishikawa, M. Miyamoto, T. Ito, E. Tsuchiya, S. Kondo, Y.
Nakamura, and Y. Daigo: Increased expression of insulin-like growth factor-Ⅱ messenger
RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. Clinical
M. Kanehira, T. Katagiri, A. Shimo, R. Takata, T. Shuin, T. Miki, T. Fujioka, and Y. Nakamura:
Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer.
M. Kubo, J. Hata, T. Ninomiya, K. Matsuda, K. Yonemoto, T. Nakano, T. Matsushita, K. Yamazaki,
Y. Ohnishi, S. Saito, T. Kitazono, S. Ibayashi, K. Sueishi, M. Iida, Y. Nakamura, and Y. Kiyohara:
A nonsynonymous SNP in PRKCH increases the risk of cerebral infarction. Nature Genetics,
39:212-217, 2007
C. Suzuki, K. Takahashi, S. Hayama, N. Ishikawa, T. Kato, T. Ito, E. Tsuchiya, Y. Nakamura, and
Y. Daigo: Identification of Myc-associated protein with JmjC domain as a novel therapeutic target
oncogene for lung cancer. Molecular Cancer Therapeutics, 6:542-551, 2007
T. Yamabuki, A. Takano, S. Hayama, N. Ishikawa, T. Kato, M. Miyamoto, T. Ito, H. Ito, Y. Miyagi,
H. Nakayama, M. Fujita, M. Hosokawa, E. Tsuchiya, N. Kohno, S. Kondo, and Y. Nakamura, and
Y. Daigo: Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal
carcinomas. Cancer Research, 67:2517-2525, 2007
K. Saigusa, I. Imoto, C. Tanikawa, M. Aoyagi, K. Ohno, Y. Nakamura, and J. Inazawa: RGC32, a
novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
Oncogene, 26:1110-1121, 2007
Y. Ebana, K. Ozaki, K. Inoue, H. Sato, A. Iida, H. Lwin, S. Saito, H. Mizuno, A. Takahashi, T.
Nakamura, Y. Miyamoto, S. Ikegawa, K. Odashiro, M. Nobuyoshi, N. Kamatani, M. Hori, M. Isobe,
Y. Nakamura, and T. Tanaka: A functional SNP in ITIH3 is associated with susceptibility to
myocardial infarction. Journal of Human Genetics, 52:220-229, 2007
M.-L. Lin, J.-H. Park, T. Nishidate, Y. Nakamura, and T. Katagiri: Involvement of maternal
embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with
Bcl-G, a pro-apoptotic member of the Bcl-2 family. Breast Cancer Research, 9:R17, 2007
R. Takata, T. Katagiri, M. Kanehira, T. Shuin, T. Miki, M. Namiki, K. Kohri, T. Tsunoda, T. Fujioka,
and Y. Nakamura: Validation study of the prediction system for clinical response of M-VAC
neoadjuvant chemotherapy. Cancer Science, 98:113-117, 2007
M. Hosokawa, A. Takehara, K. Matsuda, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, K.
Imai, Y. Nakamura, and H. Nakagawa: Oncogenic role of KIAA0101 interacting with proliferating
cell nuclear antigen in pancreatic cancer. Cancer Research, 67:2568-2576, 2007
J. Hata, K. Matsuda, T. Ninomiya, K. Yonemoto, T. Matsushita, Y. Ohnishi, S. Saito, T. Kitazono,
S. Ibayashi, M. Iida, Y. Kiyohara, Y. Nakamura, and M. Kubo: Functional SNP in a Sp1-binding
site of AGTRL1 gene is associated with susceptibility to brain infarction. Human Molecular
Genetics, 16:630-639, 2007
N. Osawa, D. Koga, S. Araki, T. Uzu,T. Tsunoda, A. Kashiwagi, Y. Nakamura, and S. Maeda:
Combinational effect of genes for the renin-angiotensin system in conferring susceptibility to
diabetic nephropathy. Journal of Human Genetics, 52:143-151, 2007
Y. Onouchi, M. Tamari, A. Takahashi, T. Tsunoda, M. Yashiro, Yo. Nakamura, H. Yanagawa, K.
Wakui, Y. Fukushima, T. Kawasaki, Yu. Nakamura, and A. Hata: A gennomewide linkage
analysis of Kawasaki disease: evidence for linkage to chromosome 12. Journal of Human
Genetics, 52:179-190, 2007
Y. Miyamoto, A. Mabuchi, D. Shi, T. Kubo, Y. Takatori, S. Saito, M. Fujioka, A. Sudo, A. Uchida,
S. Yamamoto, K. Ozaki, M. Takigawa, T. Tanaka, Y. Nakamura, Q. Jiang, and S. Ikegawa: A
functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.
M. Kanehira, Y. Harada, R. Takata, T. Shuin, T. Miki, T. Fujioka, Y. Nakamura and T. Katagiri:
Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis.
Oncogene, 26:6448-6455, 2007
S. Hayama, Y. Daigo, T. Yamabuki, D. Hirata, T. Kato, M. Miyamoto, T. Ito, E. Tsuchiya, S.
Kondo, and Y. Nakamura: Phosphorylation and activation of cell division cycle associated 8 by
aurora kinase B plays a significant role in human lung carcinogenesis. Cancer Research,
67:4113-4122, 2007
901. K. Tamura, M. Furihata, T. Tsunoda, S. Ashida, R. Takata, W. Obara, H. Yoshioka, Y. Daigo, Y.
Nasu, H. Kumon, H. Konaka, M. Namiki, K. Tozawa, K. Kohri, N. Tanji, M. Yokoyama, T.
Shimazui, H. Akaza, Y. Mizutani, T. Miki, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa:
Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression
profiles. Cancer Research, 67:5117-5125, 2007
902. A. Bourdon, L. Minai, V. Serre, J.-P. Jais, E. Sarzi, S. Aubert, D. Chretien, P. de Lonlay, V.
Paquis-Flucklinger, H. Arakawa, Y. Nakamura, A. Munnich, and A. Rotig: Mutation of RRM2B,
encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA
depletion. Nature Genetics, 39:776-780, 2007
903. K. M. Giacomini, R. M. Krauss, D. M. Roden, M. Eichelbaum, M. R. Hayden, and Y. Nakamura:
When good drugs go bad (commentary). Nature, 446:975-977, 2007
904. H. Zembutsu, M. Yanada, A. Hishida, T. Katagiri, T. Tsuruo, I. Sugiura, J. Takeuchi, N. Usui, T.
Naoe, Y. Nakamura, and R. Ohno: Prediction of risk of disease recurrence by genome-wide
cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic
leukemia treated with imatinib-combined chemotherapy. International Journal of Oncology,
31:313-322, 2007
905. M. Fujikawa, T. Katagiri, A. Tugores, Y. Nakamura, and F. Ishikawa: ESE-3, an Ets family
transcription factor, is up-regulated in cellular senescence. Cancer Science, 98:1468-1475, 2007
906. T. Kato, N. Sato, S. Hayama, T. Yamabuki, T. Ito, M. Miyamoto, S. Kondo, Y. Nakamura, and Y.
Daigo: Activation of holliday junction-recognizing protein involved in the chromosomal stability
and immortality of cancer cells. Cancer Research, 67:8544-8553, 2007
907. K. Ueda, T. Katagiri, T. Shimada, S. Irie, T. Sato, Y. Nakamura, and Y. Daigo: Comparative
profiling of serum glycoproteome by sequential purification of glycoproteins and
2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker
discovery for cancer. Journal of Proteome Research, 6:3475-3483, 2007
908. M. Taniwaki, A. Takano, N. Ishikawa, W. Yasui, K. Inai, H. Nishimura, E. Tsuchiya, N. Kohno, Y.
Nakamura, and Y. Daigo: Activation of KIF4A as a prognostic biomarker and therapeutic target for
lung cancer. Clinical Cancer Research, 13:6624-6631, 2007
909. T. Suda, T. Tsunoda, Y. Daigo, Y. Nakamura, and H. Tahara: Identification of HLA-A24-restricted
epitope-peptides derived from gene products upregulated in lung and esophageal cancers as
novel targets for immunotherapy. Cancer Science, 98:1803-1808, 2007
910. Y. Mano, K. Takahashi, N. Ishikawa, A. Takano, W. Yasui, K. Inai, H. Nishimura, E. Tsuchiya, Y.
Nakamura, and Y. Daigo: Fibroblast growth factor receptor 1 oncogene partner as a novel
prognostic biomarker and therapeutic target for lung cancer. Cancer Science, 98:1902-1913,
2007
911. S. Senju, H. Suemori, H. Zembutsu, Y. Uemura, S. Hirata, D. Fukuma, H. Matsuyoshi, M.
Shimomura, M. Haruta, S. Fukushima, Y. Matsunaga, T. Katagiri, Y. Nakamura, M. Furuya, N.
Nakatsuji, and Y. Nishimura: Genetically manipulated human embryonic stem cell-derived
dendritic cells with immune regulatory function. Stem Cells, 25:2720-2729, 2007
912. P.-C. Cha, T. Mushiroda, A. Takahashi, S. Saito, H. Shimomura, Y. Wanibuchi, T. Suzuki, N.
Kamatani, and Y. Nakamura: High-resolution SNP and haplotype maps of the human
gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in
GGCX with warfarin maintenance-dose requirement of the Japanese population. Journal of
913. K. Yamazaki, Y. Onouchi, M. Takazoe, M. Kubo, Y. Nakamura, and A. Hata: Association analysis
of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients.
914. Y. Tsukumo, A. Tomida, O. Kitahara, Y. Nakamura, S. Asada, K. Mori, and T. Tsuruo:
Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. Journal of
Biological Chemistry, 282:29264-29272, 2007
915. A. Takehara, M. Hosokawa, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Nakamura, and H.
Nakagawa: γ-aminobutyric acid (GABA) stimulates pancreatic cancer growth through
overexpressing GABAA receptor π subunit. Cancer Research, 67:9704-9712, 2007
916. M. Kunizaki, R. Hamamoto, F. P. Silva, K. Yamaguchi, T. Nagayasu, M. Shibuya, Y. Nakamura,
and Y. Furukawa: The lysine 831 of vascular endothelial growth factor receptor 1 is a novel
target of methylation by SMYD3. Cancer Research, 67:10759-10765, 2007
917. S. Kudo, R. Konda, W. Obara, D. Kudo, K. Tani, Y. Nakamura, and T. Fujioka: Inhibition of tumor
growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene
transfer in murine renal cell carcinoma. Oncology Reports, 18:785-791, 2007
918. The International HapMap Consortium:, A second generation human haplotype map of over 3.1
million SNPs. Nature, 449:851-861, 2007
919. P. C. Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, X. Xie, E. H. Byrne, S. A.
McCarroll, R. Gaudet, S. F. Schaffner, E. S. Lander, and The International HapMap Consortium:
Genome-wide detection and characterization of positive selection in human populations. Nature,
449:913-918, 2007
920. N. Ishikawa, A. Takano, W. Yasui, K. Inai, H. Nishimura, H. Ito, Y. Miyagi, H. Nakayama, M. Fujita,
M. Hosokawa, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Cancer-testis antigen
lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung
and esophageal carcinomas. Cancer Research, 67:11601-11611, 2007
921. T. Yanagiya, A. Tanabe, A. Iida, S. Saito, A. Sekine, A. Takahashi, T. Tsunoda, S. Kamohara, Y.
Nakata, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima,
S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Funahashi, K. Hamaguchi, K. Tanaka, K. Yamada, T.
Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, Y.
Nakamura, and K. Hotta: Association of single-nucleotide polymorphisms in MTMR9 gene with
obesity. Human Molecular Genetics, 16:3017-3026, 2007
922. M. Kamiyama, M. Kobayashi, S. Araki, A. Iida, T. Tsunoda, K. Kawai, M. Imanishi, M. Nomura, T.
Babazono, Y. Iwamoto, A. Kashiwagi, K. Kaku, R. Kawamori, D.P.K. Ng, T. Hansen, P. Gaede, O.
Pedersen, Y. Nakamura, and S. Maeda: Polymorphisms in the 3'UTR in the neurocalcin δ gene
affect mRNA stability, and confer susceptibility to diabetic nephropathy. Human Genetics,
122:397-407, 2007
923. S. Takitoh, S. Fujii, Y. Mase, J. Takasaki, T. Yamazaki, Y. Ohnishi, M. Yanagisawa, Y. Nakamura,
and N. Kamatani: Accurate automated clustering of two-dimensional data for single-nucleotide
polymorphism genotyping by a combination of clustering methods: evaluation by large-scale real
data. Bioinformatics, 23:408-413, 2007
924. J. Kwong, L, Shuk-Nga Chow, A. Yue-Hang Wong, W.-K. Hung, G. Tin-Yun Chung, K.-F. To, F.L.
Chan, Y. Daigo, Y. Nakamura, D.P. Huang, and K.-W. Lo: Epigenetic inactivation of the deleted
in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. Genes Chromosomes
and Cancer, 46:171–180, 2007
925. A. Tanabe, T. Yanagiya, A. Iida, S. Saito, A. Sekine, A. Takahashi, T. Nakamura, T. Tsunoda, S.
Kamohara, Y. Nakata, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, T. Funahashi, S.
Miyazaki, K. Tokunaga, K. Hamaguchi, T. Shimada, K. Tanaka, K. Yamada, T. Hanafusa, S.
Oikawa, H. Yoshimatsu, T. Sakata, Y. Matsuzawa, N. Kamatani, Y. Nakamura, and K. Hotta:
Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form
secretory granules with appetite-related neuropeptides are associated with obesity . Journal of
Clinical Endocrinology and Metabolism, 92:1145-1154, 2007
926. Y. Aoki, A. Toyama, T. Shimada, T. Sugita, C. Aoki, Y. Umino, A. Suzuki, D. Aoki, Y. Daigo, Y.
Nakamura, and TA Sato: A novel method for analyzing formalin-fixed paraffin embedded (FFPE)
tissue sections by mass spectrometry imaging. Proceedings of the Japan Academy. Series
B-Physical and Biological Sciences, 83:205-214, 2007
927. M. Harada, K. Nakashima, T. Hirota, M. Shimizu, S. Doi, K. Fujita, T. Shirakawa, T. Enomoto, M.
Yoshikawa, H. Moriyama, K. Matsumoto, H. Saito, Y. Suzuki, Y. Nakamura, and M. Tamari:
Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult
asthma. American Journal of Respiratory Cell and Molecular Biology , 36:491-496, 2007
928. T. Kidokoro, C. Tanikawa, Y. Furukawa, T. Katagiri, Y. Nakamura, and K. Matsuda: CDC20, a
potential cancer therapeutic target, is negatively regulated by p53. Oncogene, 27:1562-1571,
2008
929. N. Hosono, M. Kubo, Y. Tsuchiya, H. Sato, T. Kitamoto, S. Saito, Y. Ohnishi, and Y. Nakamura:
Multiplex PCR-based real-time Invader assay (mPCR-RETINA): a novel SNP-based method for
detecting allelic asymmetries within copy number variation regions. Human Mutation, 29:182-189,
2008
930. Y. Onouchi, T. Gunji, J. C. Burns, C. Shimizu, J.W. Newburger, M. Yashiro, Yo. Nakamura,
H.Yanagawa, K. Wakui, Y. Fukushima, F. Kishi, K. Hamamoto, M. Terai, Y. Sato, K. Ouchi, T.
Saji, A. Nariai, Y. Kaburagi, T. Yoshikawa, K. Suzuki, T. Tanaka, T. Nagai, H. Cho, A. Fujino, A.
Sekine, R. Nakamichi, T. Tsunoda, T. Kawasaki, Yu. Nakamura, and A. Hata: ITPKC functional
polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery
aneurysms. Nature Genetics, 40:35-42, 2008
931. F. P. Silva, R. Hamamoto, M. Kunizaki, M. Tsuge, Y. Nakamura, and Y. Furukawa: Enhanced
methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer
cells. Oncogene, 27:2686-2692, 2008
932. K. Obama, S. Satoh, R. Hamamoto, Y. Sakai, Y. Nakamura, and Y. Furukawa: Enhanced
expression of RAD51 associating protein-1 is involved in the growth of intrahepatic
cholangiocarcinoma cells. Clinical Cancer Research, 14:1333-1339, 2008
933. M. Kato, F. Miya, Y. Kanemura, T. Tanaka, Y. Nakamura, and T. Tsunoda: Recombination rates
of genes expressed in human tissues. Human Molecular Genetics, 17:577-586, 2008
934. A. C. C. Leung,, V. C. L. Wong, L. C. Yang, P. L. Chan, Y. Daigo, Y. Nakamura, R. Z. Qi, L. Miller,
E. T.-K. Liu, L. D. Wang, J.-L. Li, S. Law, S. W. Tsao, and M. L. Lung: Frequent decreased
expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth
properties and impact on global gene expression in esophageal carcinoma. International Journal
of Cancer, 122:587-594, 2008
935. A. Shimo, C. Tanikawa, T. Nishidate, K. Matsuda, M.-L. Lin, J.-H. Park, T. Ohta, K. Hirata, M.
Fukuda, Y. Nakamura, and T. Katagiri: Involvement of KIF2C/MCAK overexpression in mammary
carcinogenesis. Cancer Science, 99:62-70, 2008
936. M. Uemura, K. Tamura, S. Chung, S. Honma, A. Okuyama, Y. Nakamura, and H. Nakagawa:
Novel 5α-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate
937. Y. Kamatani, K. Matsuda, T. Ohishi, S. Ohtsubo, K. Yamazaki, A. Iida, N. Hosono, M. Kubo, W.
Yumura, K. Nitta, T. Katagiri, Y. Kawaguchi, N. Kamatani, and Y. Nakamura: Identification of a
significant association of a single nucleotide polymorphism in TNXB with systemic lupus
erythematosus in a Japanese population. Journal of Human Genetics, 53:64-73, 2008
938. C. Fukukawa, H. Hanaoka, S. Nagayama, T. Tsunoda, J. Toguchida, K. Endo, Y. Nakamura, and
T. Katagiri: Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody
against FZD10. Cancer Science, 99:432-440, 2008
939. J. Brunet, A. W. Pfaff, A. Abidi, M. Unoki, Y. Nakamura, M. Guinard, J.-P. Klein, E. Candolfi, and
M. Mousli: Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to
enable its proliferation. Cellular Microbiology, 10:908-920, 2008
940. N. Kato, T. Miyata, Y. Tabara, T. Katsuya, K. Yanai, H. Hanada, K. Kamide, J. Nakura, K. Kohara,
F. Takeuchi, H. Mano, M. Yasunami, A. Kimura, Y. Kita, H. Ueshima, T. Nakayama, M. Soma, A.
Hata, A. Fujioka, Y. Kawano, K. Nakao, A. Sekine, T. Yoshida, Y. Nakamura, T. Saruta, T.
Ogihara, S. Sugano, T. Miki, and H. Tomoike: High-density association study and nomination of
susceptibility genes for hypertension in the Japanese national project. Human Molecular Genetics,
17:617-627, 2008
941. T. Oishi, A. Iida, S. Otsubo, Y. Kamatani, M. Usami, T. Takei, K. Uchida, K. Tsuchiya, S. Saito, Y.
Ohnisi, K. Tokunaga, K. Nitta,Y. Kawaguchi, N. Kamatani, Y. Kochi, K. Shimane, K. Yamamoto, Y.
Nakamura, W. Yumura, and K. Matsuda: A functional SNP in the NKX2.5-binding site of ITPR3
promoter is associated with susceptibility to Systemic Lupus Erythematosus in Japanese
942. Y. Daigo, Y. Nakamura: From cancer genomics to thoracic oncology: discovery of new
biomarkers and therapeutic targets for lung and esophageal carcinoma. (review article) General
Thoracic and Cardiovascular Surgery, 56:43-53, 2008
943. K. Kiyotani, T. Mushiroda, M. Kubo, H. Zembutsu, Y. Sugiyama, and Y. Nakamura: Association
of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer
Science, 99:967-972, 2008
944. K. Kiyotani, T. Mushiroda, M. Sasa, Y. Bando, I. Sumitomo, N. Hosono, M. Kubo, Y. Nakamura,
and H. Zembutsu: Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients
receiving adjuvant tamoxifen therapy. Cancer Science, 99:995-999, 2008
945. T. Kato, N. Sato, A. Takano, M. Miyamoto, H. Nishimura, E. Tsuchiya, S. Kondo, Y. Nakamura,
and Y. Daigo: Activation of placenta-specific transcription factor distal-less homeobox 5 predicts
clinical outcome in primary lung cancer patients. Clinical Cancer Research, 14:2363-2370, 2008
946. A. Tenesa, S.M. Farrington, J.G.D. Prendergast, M.E. Porteous, M. Walker, N. Haq, R.A.
Barnetson, E. Theodoratou, R. Cetnarskyj, N. Cartwright, R. Wilson, C. Semple, A.J. Clarke,
F.J.L. Reid, L.A. Smith, K. Kavoussanakis, T. Kossler, P.D.P. Pharoah, S. Buch, C. Schafmayer,
J. Tepel, S. Schreiber, H. Volzke, C.O. Schmidt, J. Hampe, S. Wilkening, F. Canzian, J.
Chang-Claude, M. Hoffmeister, H. Brenner, G. Capella, V. Moreno, I.J. Deary, J.M. Starr, I.P.M.
Tomlinson, E. Webb, R.S. Houlston, G. Rennert, D. Ballinger, L. Rozek, S.B. Gruber, K. Matsuda,
T. Kidokoro, Y. Nakamura, B.W. Zanke, C.M.T. Greenwood, J. Rangrej, R. Kustra, A. Montpetit,
T.J. Hudson, S. Gallinger, H. Campbell, and M.G. Dunlop:
A genome-wide association scan
identifies colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and
18q21. Nature Genetics, 40:631-637, 2008
947. H. Mototani, A. Iida, M. Nakajima, T. Furuichi, Y. Miyamoto, T. Tsunoda, A. Sudo, A. Kotani, A.
Uchida, K. Ozaki, Y. Tanaka, Y. Nakamura, T. Tanaka, K. Notoya, and S. Ikegawa: A functional
SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Human Molecular
Genetics, 17:1790-1797, 2008
948. Y. Mizukami, K. Kono, Y. Daigo, A. Takano, T. Tsunoda, Y. Kawaguchi, Y. Nakamura, and H.
Fujii: Detection of novel Cancer-Testis antigen-specific T-cell responses in TIL, regional lymph
nodes and PBL in patients with esophageal squamous cell carcinoma. Cancer Science,
99:1448-1454, 2008
949. T. Mushiroda, S. Wattanapokayakit, A. Takahashi, T. Nukiwa, S. Kudoh, T. Ogura, H. Taniguchi,
Pirfenidone Clinical Study Group, M. Kubo, N. Kamatani, and Y. Nakamura: A genome-wide
association study identifies an association of a common variant in TERT with susceptibility to
idiopathic pulmonary fibrosis. Journal of Medical Genetics, 45:654-656, 2008
950. M. Hosokawa, K. Kashiwaya, M. Furihara, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, K.
Imai, Y. Nakamura, and H. Nakagawa: Overexpression of cysteine proteinase inhibitor cystatin 6
promotes pancreatic cancer growth. Cancer Science, 99:1626-1632, 2008
951. The Study Group of Millennium Genome Project for Cancer, (H. Sakamoto, K. Yoshimura, N.
Saeki, H. Katai, T. Shimoda, Y. Matsuno, D. Saito, H. Sugimura, F. Tanioka, S. Kato, N.
Matsukura, N. Matsuda, T. Nakamura, I. Hyodo, T. Nishina, W. Yasui, H. Hirose, M. Hayashi, E.
Toshiro, S. Ohnami, A. Sekine, Y. Sato, H. Totsuka, M. Ando, R. Takemura, Y. Takahashi, M.
952.
953.
954.
955.
956.
957.
958.
959.
960.
961.
962.
963.
964.
965.
966.
967.
Ohdaira, K. Aoki, I. Honmyo, S. Chiku, K. Aoyagi, H. Sasaki, S. Ohnami, K. Yanagihara, K.-A.
Yoon, M.-C. Kook, Y.-S. Lee, S. R. Park, C. G. Kim, I. J. Choi, T. Yoshida, Y. Nakamura, and S.
Hirohashi): Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric
cancer. Nature Genetics, 40:730-740, 2008
T. Ueki, T. Nishidate, J.H. Park, M.L. Lin, A. Shimo, K. Hirata, Y. Nakamura, and T. Katagiri:
Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless
/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells. Oncogene,
27:5672-5683, 2008
Y. Miyamoto, D. Shi, M. Nakajima, K. Ozaki, A. Sudo, A. Kotani, A. Uchida, T. Tanaka, N. Fukui,
T. Tsunoda, A. Takahashi, Y. Nakamura, Q. Jiang, and S. Ikegawa: Common variants in DVWA
on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nature Genetics,
40:994-998, 2008
H. Unoki, A. Takahashi, T. Kawaguchi, K. Hara, M. Horikoshi, G. Andersen, D.P.K. Ng, J.
Holmkvist, K. Borch-Johnsen, T. J. Rgensen, A. Sandbaek, T. Lauritzen, T. Hansen, S. Nurbaya,
T. Tsunoda, M. Kubo, T. Babazono, H. Hirose, M. Hayashi, Y. Iwamoto, A. Kashiwagi, K. Kaku, R.
Kawamori, E. S. Tai, O. Pedersen, N. Kamatani, T. Kadowaki, R. Kikkawa, Y. Nakamura, and S.
Maeda: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and
European populations. Nature Genetics, 40:1098-1102, 2008
M. Harao , S. Hirata, A. Irie, S. Senju, T. Nakatsura, H. Komori, Y. Ikuta, K. Yokomine, K. Imai,
M. Inoue, K. Harada, T. Mori, T. Tsunoda, S. Nakatsuru, Y. Daigo, H. Nomori, Y.
Nakamura, H. Baba, and Y. Nishimura: HLA-A2-restricted CTL epitopes of a novel lung
cancer-associated cancer testis antigen, cell division cycle associated 1, can induce
tumor-reactive CTL. International Journal of Cancer, 123:2616-2625, 2008
K. Imai, S. Hirata, A. Irie, S. Senju, Y. Ikuta, K. Yokomine, M. Harao, M. Inoue, T. Tsunoda, S.
Nakatsuru, H. Nakagawa, Y. Nakamura, H. Baba, and Y. Nishimura: Identification of a novel
tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of
pancreatic, gastric and colorectal cancers. Clinical Cancer Research, 14:6487-6495, 2008
D.N. Nikolova, H. Zembutsu, T. Sechanov, K. Vidinov, L.S. Kee, R. Ivanova, E. Becheva, M.
Kocova, D. Toncheva, and Y. Nakamura: Genome-wide gene expression profiles of thyroid
carcinoma: Identification of molecular targets for treatment of thyroid carcinoma. Oncology
Reports, 20:105-121, 2008
Y. Nakamura: Pharmacogenomics and drug toxicity. (Editorial) New Eng. J. Med., 359:856-858,
2008
K. Arita, M. Ariyoshi, H. Tochio, Y. Nakamura, and M. Shirakawa: Recognition of hemi-methylated
DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature, 455:818-822, 2008
H. Inoue, M. Iga, H. Nabeta, T. Yokoo, Y. Suehiro, S. Okano, M. Inoue, H. Kinoh, T. Katagiri, K.
Takayama, Y. Yonemitsu, M. Hasegawa, Y. Nakamura, Y. Nakanishi, and K. Tani:
Non-transmissible SeV encoding GM-CSF is a novel and potent vector system to produce
autologous tumor vaccines. Cancer Science, 99:2315-2326, 2008
R. Konda, J. Sugimura, F. Sohma, T. Katagiri, Y. Nakamura, and T. Fujioka: Over expression of
hypoxia-inducible protein 2, hypoxia-inducible factor-1αand nuclear factor κB is putatively
involved in acquired renal cyst formation and subsequent tumor transformation in patients with
end stage renal failure. The Journal of Urology, 180:481-485, 2008
K. Hotta, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada,
H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Funahashi, K.
Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y.
Matsuzawa, K. Tanaka, N. Kamatani, and Y. Nakamura: Variations in the FTO gene are
associated with severe obesity in the Japanese. Journal of Human Genetics, 53:546-553, 2008
M. Kato, Y. Nakamura, and T. Tsunoda: An algorithm for inferring complex haplotypes in a region
of copy-number variation. Am. J. Human Genetics, 83:157-169, 2008
M. Kato, Y. Nakamura, and T. Tsunoda: MOCSphaser: a haplotype inference tool from a mixture
of copy number variation and single nucleotide polymorphism data. Bioinformatics, 24:1645-1646,
2008
Y. Yamaguchi-Kabata, K. Nakazono, A. Takahashi, S. Saito, N. Hosono, M. Kubo, Y. Nakamura,
and N. Kamatani: Japanese population structure, based on SNP genotypes from 7003 individuals
compared to other ethnic groups: Effects on population-based association studies. Am. J. Human
Genetics, 83:445-456, 2008
K. Yasuda, K. Miyake, Y. Horikawa, K. Hara, H. Osawa, H. Furuta, Y. Hirota, H. Mori, A. Jonsson,
Y. Sato, K. Yamagata, Y. Hinokio, H.-Y. Wang, T. Tanahashi, N. Nakamura, Y. Oka, N. Iwasaki, Y.
Iwamoto, Y. Yamada, Y. Seino, H. Maegawa, A. Kashiwagi, J. Takeda, E. Maeda, H. D. Shin, Y.
M. Cho, K. S. Park, H. K. Lee, M. C. Y. Ng, R. C. W. Ma, W.-Y. So, J. C. N. Chan, V. Lyssenko, T.
Tuomi, P.Nilsson, L. Groop, N. Kamatani, A. Sekine, Y. Nakamura, K. Yamamoto, T. Yoshida, K.
Tokunaga, M. Itakura, H. Makino, K. Nanjo, T. Kadowaki, and M. Kasuga: Variants in KCNQ1 are
associated with susceptibility to type 2 diabetes mellitus. Nature Genetics, 40:1092-1097, 2008
Y. Okada, M. Mori, R. Yamada, A. Suzuki, K. Kobayashi, M. Kubo, Y. Nakamura, and K.
Yamamoto: SLC22A4 polymorphism and rheumatoid arthritis susceptibility: A replication study in
a Japanese population and a metaanalysis. The Journal of Rheumatology, 35:1723-1728, 2008
968. S. Omori, Y. Tanaka, A. Takahashi, H. Hirose, A. Kashiwagi, K. Kaku, R. Kawamori, Y. Nakamura,
and S. Maeda: Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11
with susceptibility of type 2 diabetes in a Japanese population. Diabetes, 57:791-795, 2008
969. K. Misawa, S. Fujii, T. Yamazaki, A. Takahashi, J. Takasaki, M. Yanagisawa, Y. Ohnishi, Y.
Nakamura, and N. Kamatani: New correction algorithms for multiple comparisons in case-control
multilocus association studies based on haplotypes and diplotype configurations. Journal of
970. A. Suzuki, R. Yamada, Y. Kochi, T. Sawada, Y. Okada, K. Matsuda, Y. Kamatani, M. Mori, K.
Shimane, Y. Hirabayashi, A. Takahashi, T. Tsunoda, A. Miyatake, M. Kubo, N. Kamatani, Y.
Nakamura, and K. Yamamoto: Functional SNPs in CD244 increase the risk of rheumatoid arthritis
in a Japanese population. Nature Genetics, 40:1224-1229, 2008
971. K. Hotta, M. Nakamura, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I.
Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto
T. Funahashi, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T.
Sakata, Y. Matsuzawa, K. Tanaka, N. Kamatani, and Y. Nakamura: INSIG2 gene rs7566605
polymorphism is associated with severe obesity in Japanese. Journal of Human Genetics,
53:857-862, 2008
972. K. Iwahori, T. Osaki, S. Serada, M. Fujimoto, H. Suzuki, Y. Kishi, A. Yokoyama, H. Hamada, Y.
Fujii, K. Yamaguchi, T. Hirashima, K. Matsui, I. Tachibana, Y. Nakamura, I. Kawase, and T. Naka:
Megakaryocyte potentiating factor as a tumor maker of malignant pleural mesothelioma:
Evaluation in comparison with mesothelin. Lung Cancer, 62:45-54, 2008
973. T. Hirota, M. Harada, M. Sakashita, S. Doi, A. Miyatake, K. Fujita, T. Enomoto, M. Ebisawa, S.
Yoshihara, E. Noguchi, H. Saito, Y. Nakamura, and M. Tamari: Genetic polymorphism regulating
ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma
in a Japanese population. J Allergy Clin Immunol, 121:769-770, 2008
974. M. Sakashita, T. Yoshimoto, T. Hirota, M. Harada, K. Ohkubo, Y. Osawa, S. Fujieda, Y.
Nakamura, K. Yasuda, K. Nakanishi, and M. Tamari: Association of serum interleukin-33 level
and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin Exp Allergy,
38:1875-1881, 2008
975. C. Okuma, T. Kaketa, A. Hikita, K. Matsuda, M. Nakamura, Y. Nagase, Y. Oshima, M. Iwasawa,
Y. Nakamura, H. Kurosawa, K. Nakamura, and S. Tanaka: Potential involvement of p53 in
ischemia/reperfusion-induced osteonecrosis. Journal of Bone and Mineral Metabolism,
26:576-585, 2008
976. S. Kobayashi, K. Ikari, H. Kaneko, Y. Kochi, K. Yamamoto, K. Shimane, Y. Nakamura, Y. Toyama,
T. Mochizuki, S. Tsukahara, Y. Kawaguchi, C. Terai, M. Hara, T. Tomatsu, H. Yamanaka, T.
Horiuchi, K. Tao, K. Yasutomo, D. Hamada, N. Yasui, H. Inoue, M. Itakura, H. Okamoto, N.
Kamatani, and S. Momohara: Association of STAT4 with susceptibility to rheumatoid arthritis and
systemic lupus erythematosus in the Japanese population. Arthritis & Rheumatism,
58:1940–1946, 2008
977. M. Harada, T. Hirota, A.I. Jodo, S. Doi, M. Kameda, K. Fujita, A. Miyatake, T. Enomoto, E.
Noguchi, S. Yoshihara, M. Ebisawa, H. Saito, K. Matsumoto, Y. Nakamura, S.F. Ziegler, and
M.Tamari: Functional analysis of the Thymic Stromal Lymphopoietin Variants in Human Bronchial
Epithelial Cells. Am J Respir Cell Mol Biol, 40:368-374, 2009
978. S. Chantarangsu , T. Mushiroda, S. Mahasirimongkol, S. Kiertiburanakul, S. Sungkanuparph, W.
Manosuthi, W. Tantisiriwat, A. Charoenyingwattana, T. Sura, W. Chantratita, and Y. Nakamura:
HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in Thai
HIV-infected patients. Pharmacogenetics and Genomics, 19:139-146, 2009
979. D. N. Nikolova, N. Doganov, R. Dimitrov, K. Angelov, S.-K. Low, I. Dimova, D. Toncheva, Y.
Nakamura, and H. Zembutsu: Genome-wide gene expression profiles of ovarian carcinoma:
identification of molecular targets for the treatment of ovarian carcinoma. Molecular Medicine
Reports, 2:365-384, 2009
980. K. Yamazaki, A. Takahashi, M Takazoe, M. Kubo, Y. Onouchi, A. Fujino, N. Kamatani, Y.
Nakamura, and A. Hata: Positive association of genetic variants in the upstream region of NXT2-3
with Crohn's disease in Japanese patients. Gut, 58:228-232, 2009
981. D. Hirata, T. Yamabuki, D. Miki, T. Ito, E. Tsuchiya, M. Fujita, M. Hosokawa, K. Chayama, Y.
Nakamura, and Y. Daigo: Involvement of epithelial cell transforming sequence-2 oncoantigen in
lung and esophageal cancer progression. Clinical Cancer Research, 15:256-266, 2009
982. S. Dobashi, T. Katagiri, E. Hirota, S. Ashida, Y. Daigo, T. Shuin, T. Fujioka, T. Miki, and Y.
Nakamura: Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
Oncology Reports, 21:305-312, 2009
983. H. Zembutsu, Y. Suzuki, A. Sasaki, T. Tsunoda, M. Okazaki, M. Yoshimoto, T. Hasegawa, K.
Hirata, and Y. Nakamura: Predicting response to Docetaxel neoadjuvant chemotherapy for
advanced breast cancers through genome-wide gene expression profiling. International Journal
of Oncology, 34:361-370, 2009
984. Y. Nakamura: DNA variations in human and medical genetics: 25 years of my experience.
(review) Journal of Human Genetics, 54:1-8, 2009
985. K. Ozaki, H. Sato, K. Inoue, T. Tsunoda, Y. Sakata, H. Mizuno, T.-H. Lin, Y. Miyamoto, A. Aoki, Y.
Onouchi, S.-H. Sheu, S. Ikegawa, K. Odashiro, M. Nobuyoshi, S.-H. H. Juo, M. Hori, Y.
Nakamura, and T. Tanaka: SNPs in BRAP associated with risk of myocardial infarction in Asian
populations. Nature Genetics, 41:329-333, 2009
986. K. Kashiwaya, M. Hosokawa, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, Y. Nakamura,
and H. Nakagawa: Identification of C2orf18, Termed ANT2BP (ANT2-binding protein), as one of
key molecules involved in pancreatic carcinogenesis.
Cancer Science, 100:457-464, 2009
987. S. Nagayama, E. Yamada, Y. Kohno, T. Aoyama, C. Fukukawa, H. Kubo, G. Watanabe, T.
Katagiri, Y. Nakamura, Y. Sakai, and J. Toguchida: Inverse correlation of the upregulation of
FZD10 expression and the activation of β-catenin in synchronous colorectal tumors. Cancer
Science, 100:405-412, 2009
988. K. Ueda, Y. Fukase, T. Katagiri, N. Ishikawa, S. Irie, T. Sato, H. Ito, H. Nakayama, Y. Miyagi, E.
Tsuchiya, N. Kohno, M. Shiwa, Y. Nakamura, and Y. Daigo: Targeted serum glycoproteomics
for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled
ProteinChip arrays. Proteomics, 9:2182-2192, 2009
989. The International Warfarin Pharmacogenetics Consortium: Estimation of the warfarin dose with
clinical and pharmacogenetic data. New Eng. J. Med., 360:753-764, 2009
990. E.T. Betcheva, T. Mushiroda, A. Takahashi, M. Kubo, S.K. Karachanak, I.T. Zaharieva, R.V.
Vazharova, I.I. Dimova, V.K. Milanova, T. Tolev, G. Kirov, M.J. Owen, M.C. O'Donovan, N.
Kamatani, Y. Nakamura, and D.I. Toncheva: Case-control association study of 59 candidate
genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia
in the Bulgarian population. Journal of Human Genetics, 54:98-107, 2009
991. C. Fukukawa, S. Nagayama, T. Tsunoda, J. Toguchida, Y. Nakamura, and T. Katagiri: Activation
of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial
sarcoma. Oncogene, 28:1110-1120, 2009
992. A. Yosifova, T. Mushiroda, D. Stoianov, R. Vazharova, I. Dimova, S. Karachanak, I. Zaharieva, V.
Milanova, N. Madjirova, I. Gerdjikov, T. Tolev, S. Velkova, G. Kirov, M. J. Owen, M. C. O’Donovan,
D. Toncheva, and Y. Nakamura: Case-control association study of 65 candidate genes revealed
a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in
Bulgarian population. Journal of Affective Disorders, 117:87-97, 2009
993. Y. Kamatani, S. Wattanapokayakit, H. Ochi, T. Kawaguchi, A. Takahashi, N. Hosono, M. Kubo, T.
Tsunoda, N. Kamatani, H. Kumada, A. Puseenam, T. Sura, Y. Daigo, K. Chayama, W.
Chantratita, Y. Nakamura, and K. Matsuda: A genome-wide association study identifies variants
in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics, 41:591-595,
2009
994. K. Tamura, M. Furihata, S. Chung, M. Uemura, H. Yoshioka, T. Iiyama, S. Ashida, Y. Nasu, T.
Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa: Stanniocalcin 2 (STC2) over-expression in
castration-resistant prostate cancer and aggressive prostate cancer.
Cancer Science,
100:914-919, 2009
995. H. Tsukada, H. Ochi, T. Maekawa, H. Abe, Y. Fujimoto, M. Tsuge, H. Takahashi, H. Kumada, N.
Kamatani, Y. Nakamura, and K. Chayama: A Polymorphism in MAPKAPK3 affects response to
interferon therapy for chronic hepatitis C. Gastroenterology, 136:1796-1805, 2009
996. E. M. Dunleavy, D. Roche, H. Tagami, N. Lacoste, D. Ray-Gallet, Y. Nakamura, Y. Daigo, Y.
Nakatani, and G. Almouzni-Pettinotti: HJURP, a key CENP-A-partner for maintenance and
deposition of CENP-A at centromeres at late telophase/G1. Cell, 137:485-497, 2009
997. M.-L. Lin, C. Fukukawa, J.-H. Park, K. Naito, K. Kijima, M. Ajiro, A. Shimo, T. Nishidate, Y.
Nakamura, and T. Katagiri: Involvement of G-patch domain containing 2 overexpression in breast
998. K. Morioka, C. Tanikawa, K. Ochi, Y. Daigo, T. Katagiri, H. Kawano, H. Kawaguchi, A. Myoui, H.
Yoshikawa, N. Naka, N. Araki, I. Kudawara, M. Ieguchi, K. Nakamura, Y. Nakamura, and K.
Matsuda: Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for
osteosarcoma. Cancer Science, 100:1227-1233, 2009
999. K. Asano, T. Matsushita, J. Umeno, N. Hosono, A. Takahashi, T. Kawaguchi, T. Matsumoto, T.
Matsui, Y. Kakuta, Y. Kinouchi, T. Shimosegawa, M. Hosokawa, Y. Arimura, Y. Shinomura, Y.
Kiyohara, T. Tsunoda, N. Kamatani, M. Iida, Y. Nakamura, and M. Kubo: A genome-wide
association study identifies three new susceptibility loci for ulcerative colitis in the Japanese
1000. S. Chung, M. Furihata, K. Tamura, M. Uemura, Y. Daigo, Y. Nasu, T. Miki, T. Shuin, T. Fujioka,
Y. Nakamura, and H. Nakagawa: Overexpressing PKIB in prostate cancer promotes its
aggressiveness by linking between PKA and Akt pathways. Oncogene, 28:2849-2859, 2009
1001. C. C. Ng, P. Y. Yew, S. M. Puah, G. Krishnan, L. F. Yap, S. H. Teo, P. V. H. Lim, S. Govindaraju,
K. Ratnavelu, C. K. Sam, A. Takahashi, M. Kubo, N. Kamatani, Y. Nakamura, and T. Mushiroda:
A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma.
1002. J.-W. Kim, M. Akiyama, J.-H. Park, M.-L. Lin, A. Shimo, T. Ueki, T. Nishidate, Y. Nakamura, and
T. Katagiri: Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory
effect on nuclear transport of PHB2/REA in breast cancer. Cancer Science, 100:1468-1478, 2009
1003. M. Unoki, J. D. Kelly, D. E. Neal, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: UHRF1 is a
novel molecular marker for diagnosis and the prognosis of bladder cancer. British Journal of
Cancer, 101:98-105, 2009
1004. C. Tanikawa, Y. Furukawa, N. Yoshida, H. Arakawa, Y. Nakamura, and K. Matsuda: XEDAR as
a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. Oncogene,
28:3081-3092, 2009
1005. K. Hotta, T. Nakamura, J. Takasaki, H. Takahashi, A. Takahashi, Y. Nakata, S. Kamohara, K.
Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, T.
Funahashi, S. Miyazaki, K. Tokunaga, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S.
Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, and Y. Nakamura:
Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed
McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome. Journal of
1006. K. Kono, Y. Mizukami, Y. Daigo, A. Takano, K. Masuda, K. Yoshida, T. Tsunoda, Y. Kawaguchi,
Y. Nakamura, and H. Fujii: Vaccination with multiple peptides derived from novel cancer-testis
antigens can induce specific T-cell responses and clinical responses in advanced esophageal
1007. N. Hosono, M. Kato, K. Kiyotani, T. Mushiroda, S. Takata, H. Sato, H. Amitan, Y. Tsuchiya, K.
Yamazaki, T. Tsunoda, H. Zenbutsu, Y. Nakamura, and M. Kubo: CYP2D6 genotyping for
functional gene-dosage analysis by allele copy number detection. Clinical Chemistry,
55:1546-1554, 2009
1008. H. Abe, H. Ochi, T. Maekawa, T. Hatakeyama, M. Tsuge, S. Kitamura, T. Kimura, D. Miki, F.
Mitsui, N. Hiraga, M. Imamura, Y. Fujimoto, S. Takahashi, Y. Nakamura, H. Kumada, and K.
Chayama: Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic
hepatitis B virus infection. Hepatology Research, 39:1159-1168, 2009
1009. K. Moriwaki, K. Noda, Y. Furukawa, K. Ohshima, A. Uchiyama, T. Nakagawa, N. Taniguchi, Y.
Daigo, Y. Nakamura, N. Hayashi, and E. Miyoshi: Deficiency of GMDS leads to escape from NK
cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology,
137:188-198, 2009
1010. S. Chung, K. Tamura, M. Furihata, M. Uemura, Y. Daigo, Y. Nasu, T. Miki, T. Shuin, T. Fujioka,
Y. Nakamura, and H. Nakagawa: Overexpression of the potential kinase,
Serine/Threonine/Tyrosine Kinase 1(STYK1 ) in castration-resistant prostate cancer. Cancer
Science, 100:2109-2114, 2009
1011. S.-K. Low, K. Kiyotani, T. Mushiroda, Y. Daigo, Y. Nakamura, and H. Zembutsu: Association
study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions
in breast cancer patients. Journal of Human Genetics, 54:564-571, 2009
1012. P.-C. Cha, T. Mushiroda, H. Zembutsu, H. Harada, N. Shinoda, S. Kawamoto, R. Shimoyama, T
Nishidate, T. Furuhata, K. Sasaki, K. Hirata, and Y. Nakamura: Single nucleotide polymorphism in
ABCG2 is associated with irinotecan-induced severe myelosuppression. Journal of Human
Genetics, 54:572-580, 2009
1013. M. Ajiro, T. Katagiri, K. Ueda, H. Nakagawa, C. Fukukawa, M.-L. Lin, J.-H. Park, T. Nishidate, Y.
Daigo, and Y. Nakamura: Involvement of RQCD1 overexpression, a novel cancer-testis antigen,
in the Akt pathway in breast cancer cells. International Journal of Oncology, 35:673-681, 2009
1014. Y. Okada, R. Yamada, A. Suzuki, Y. Kochi, K. Shimane, K. Myouzen, M. Kubo, Y. Nakamura,
and K. Yamamoto: Contribution of a Haplotype in the HLA region to anti-cyclic citrullinated
peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1. Arthritis &
Rheumatism, 60:3582-3590, 2009
1015. R. Cui, Y. Kamatani, A. Takahashi, M. Usami, N. Hosono, T. Kawaguchi, T. Tsunoda, N.
Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda: Functional variants in ADH1B and ALDH2
coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
Gastroenterology, 137:1768-1775, 2009
1016. K. Tamura, A. Makino, F. Hullin-Masuda, T. Kobayashi, M. Furihata, S. Chung, S. Ashida, T.
Miki, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa: Novel lipogenic enzyme ELOVL7
involves in prostate cancer growth through saturated long-chain fatty acid metabolism. Cancer
Research, 69:8133-8140, 2009
1017. T. Ueki, J.-H. Park, T. Nishidate, K. Kijima, K. Hirata, Y. Nakamura, and T. Katagiri:
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T
overexpression in human breast cancer cells. Cancer Research, 69:8752-8760, 2009
1018. H. Nakahara, N. Hosono, T. Kitayama, K. Sekiguchi, M. Kubo, A. Takahashi, Y. Nakamura, Y.
Yamano, and K. Kai: Automated SNPs typing system based on the Invader assay. Legal
Medicine, 11 Suppl1:S111-114, 2009
1019. C. Tanikawa, K. Ueda, H. Nakagawa, N. Yoshida, Y. Nakamura, and K. Matsuda: Regulation of
protein citrullination through p53/PADI4 network in DNA damage response. Cancer Research,
69:8761-8769, 2009
1020. M. Kato, T. Kawaguchi, S. Ishikawa, T. Umeda, R. Nakamichi, M. H. Shapero, K. W. Jones, Y.
Nakamura, H. Aburatani, and T. Tsunoda: Population-genetic nature of copy number variations in
the human genome. Human Molecular Genetics, 19:761-773, 2009
1021. S. Omori, Y. Tanaka, M. Horikoshi, A. Takahashi, K. Hara, H. Hirose, A. Kashiwagi, K. Kaku, R.
Kawamori, T. Kadowaki, Y. Nakamura, and S. Maeda: Replication study for the association of
new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese
individuals. Diabetologia, 52:1554-1560, 2009
1022. T. Matsushita, M. Kubo, K.Yonemoto, T. Ninomiya, K. Ashikawa, B. Liang, J. Hata, Y. Doi, T.
Kitazono, S. Ibayashi, M. Iida, Y. Kiyoharam and Y. Nakamura: Lack of association between
variations of PDE4D and ischemic stroke in the Japanese population. Stroke, 40:1245-1251,
2009
1023. K. Shimane, Y. Kochi, R. Yamada, Y. Okada, A. Suzuki, A. Miyake, M. Kubo, Y. Nakamura, and
K. Yamamoto: A single nucleotide polymorphism in the IRF5 promoter region is associated with
susceptibility to rheumatoid arthritis in the Japanese population Annals of the Rheumatic
Diseases, 68:377-383, 2009
1024. M. Tamari, M. Harada, T. Hirota, and Y. Nakamura: Host molecular defence mechanisms
against Chlamydophilia pneumoniae and genetic studies of immune-response-related genes in
asthma. Recent Pat Inflamm Allergy Drug Discovory, 3:17-25, 2009
1025. M. Harada, K. Obara, T. Hirota, T. Yoshimoto, Y. Hitomi, M. Sakashita, S. Doi, A. Miyatake, K.
Fujita, T. Enomoto, M. Taniguchi, N. Higashi, Y. Fukutomi, K. Nakanishi, Y. Nakamura, and M.
Tamari: A functional polymorphism in IL-18 is associated with severity of bronchial asthma. Am J
Respir Crit Care Med, 180:1048-1055, 2009
1026. Y. Hitomi, M. Ebisawa, M. Tomikawa, T. Imai, T. Kamata, T. Hirota, M. Harada, M. Sakashita, Y.
Suzuki, N. Shomojo, Y. Kohno, K. Fujita, A. Miyatake, S. Doi, T. Enomoto, M. Taniguchi, N.
Higashi, Y. Nakamura, and M. Tamari: Association of functional NLRP3 polymorphisms with
susceptibility to food-induced anaphylaxis and aspirin-induced asthma. Journal of Allergy and
Clinical Immunology, 124:779-785, 2009
1027. H. Naruse, N. Ikawa, K. Yamaguchi, Y. Nakamura, M. Arai, C. Ishioka, K. Sugano, K. Tamura, N.
Tomita, N. Matsubara, T. Yoshida, Y. Moriya, and Y. Furukawa: Determination of splice-site
mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients using
functional splicing assay. Familial Cancer, 8:509-517, 2009
1028. H. Eguchi, O. Ishikawa, H. Ohigashi, H. Takahashi, M. Yano, K. Nishiyama, Y. Tomita, R.
Uehara, A. Takehara, Y. Nakamura, and H. Nakagawa: Serum REG4 level is a predictive
biomarker for the response to preoperative chemoradiotherapy in patients with pancreatic cancer.
Pancreas, 38:791-798, 2009
1029. K. Hotta, M. Nakamura, T. Nakamura, T. Matuso, Y. Nakata, S. Kamohara, N. Miyatake, K.
Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, T.
Funahashi, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Ueno, K. Hamaguchi, K. Tanaka, K.
Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N.
Kamatani, and Y. Nakamura: Association between obesity and polymorphisms in SEC16B,
TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. Journal of Human
Genetics, 54:727-731, 2009
1030. T. Nagao, M. Kira, M. Takahashi, J. Honda, T. Hirose, A. Tangoku, H. Zembutsu, Y. Nakamura,
and M. Sasa: Serum estradiol should be monitored not only during the peri-menopausal period
but also the post-menopausal period at the time of aromatase inhibitor administration. World
Journal of Surgical Oncology, 7:88-92, 2009
1031. W. Satake, Y. Nakabayashi, I. Mizuta, Y. Hirota, C. Ito, M. Kubo, T. Kawaguchi, T. Tsunoda, M.
Watanabe, A. Takeda, H. Tomiyama, K. Nakashima, K. Hasegawa, F. Obata, T. Yoshikawa, H.
Kawakami, S. Sakoda, M. Yamamoto, N. Hattori, M. Murata, Y. Nakamura, and T. Toda:
Genome-wide association study identifies common variants at four loci as genetic risk factors for
Parkinson's disease. Nature Genetics, 41:1303-1307, 2009
1032. D.P. Zabel, C.H. Andreasen, K.S. Burgdorf, E.A. Andersson, A. Sandbaek, T. Lauritzen, K.
Borch-Johnsen, T. Jorgensen, S. Maeda, Y. Nakamura, H. Eiberg, O. Pederse, T. Hansen
Variation in the gene encoding Kruppel-like factor 7 influences body fat: studies of 14 818 Danes.
European Journal of Endocrinology, 160:603-609, 2009
1033. H. Hanaoka, T. Katagiri, C. Fukukawa, H. Yoshioka, S. Yamamoto, Y. Iida, T. Higuchi, N.
Oriuchi, B. Paudyal, P. Paudyal, Y. Nakamura, and K. Endo, K: Radioimmunotherapy of solid
tumors targeting a cell-surface protein, FZD10: therapeutic efficacy largely depends on
radiosensitivity. Annals of Nuclear Medicine, 23:479-485, 2009
1034. M. Tamari, M. Harada, T. Hirota, and Y. Nakamura: Host molecular defense mechanisms
against Chlamydophila pneumoniae and genetic studies of immune-response-related genes in
asthma. Recent Patents on Inflammation & Allergy Drug Discovery, 3:17-25, 2009
1035. A. Takano, N. Ishikawa, R. Nishino, K. Masuda, W. Yasui, K. Inai, H. Nishimura, H. Ito, H.
Nakayama, Y. Miyagi, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Identification of
Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung aancer. Cancer Research,
69:6694-6703, 2009
1036. Y. Kochi, K. Myouzen, R. Yamada, A. Suzuki, T. Kurosaki, Y. Nakamura, and K. Yamamoto:
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated
signaling. Journal of Immunology, 183:5502-5510, 2009
1037. K. Nishimoto, Y. Kochi, K. Ikari, K. Yamamoto, A. Suzuki, K. Shimane, Y. Nakamura, K. Yano, N.
Iikuni, S. Tsukahara, N. Kamatani, H. Okamoto, H. Kaneko, Y. Kawaguchi, M. Hara, Y. Toyama,
T. Horiuchi, K. Tao, K. Yasumoto, D. Hamada, N. Yasui, H. Inoue, M. Itakura, H. Yamanaka, and
S. Momohara: Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid
arthritis and systemic lupus erythematosus in Japanese. Annals of the Rheumatic Diseases,
69:368-373, 2010
1038. K. Kiyotani, T. Mushiroda, C. K. Imamura, N. Hosono, T. Tsunoda, M. Kubo, Y. Tanigawara, D.A.
Flockhart, Z. Desta, T.C. Skaar, F. Aki, K. Hirata, Y. Takatsuka, M. Okazaki, S. Ohsumi, T.
Yamakawa, M. Sasa, Y. Nakamura, and H. Zembutsu: Significant effect of polymorphisms in
CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer
patients. Journal of Clinical Oncology, 28:1287-1293, 2010
1039. N. Sato, J. Koinuma, M. Fujita, M. Hosokawa, T. Ito, E. Tsuchiya, S. Kondo, Y. Nakamura, and
Y. Daigo: Activation of WD repeat and High-mobility group box DNA binding protein 1 in
pulmonary and esophageal carcinogenesis.
1040. W. Wangsomboonsiri, S. Mahasirimongkol, S. Chantarangsu, S. Kiertiburanakul, A.
Charoenyingwattana, S. Komindr, C. Thongnak, T. Mushiroda, Y. Nakamura, W. Chantratita, and
S. Sungkanuparph: Association between HLA-B*4001 and lipodystrophy among HIV-infected
patients from Thailand who received a stavudine-containing antiretroviral regimen. Clinical
Infectious Diseases, 50:597-604, 2010
1041. M. Miyazawa, R. Ohsawa, T. Tsunoda, S. Hirono, M. Kawai, M. Tani, Y. Nakamura, and H.
Yamaue: Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor
receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer. Cancer
Science, 101:433-439, 2010
1042. M. Nuinoon, W. Makarasara, T. Mushiroda, I. Setianingsih, P. A. Wahidiyat, O. Sripichai, N.
Kumasaka, A. Takahashi, S. Svasti, T. Munkongdee, S. Mahasirimongkol, C.
Peerapittayamongkol, V. Viprakasit, N. Kamatani, P. Winichagoon, M. Kubo, Y. Nakamura, and S.
Fucharoen: A genome-wide association identified the common genetic variants influence
disease severity in β0-thalassemia/hemoglobin E. Human Genetics, 127:303-314, 2010
1043. H. Nakahara, K. Sekiguchi, N. Hosono, M. Kubo, A. Takahashi, Y. Nakamura, and K. Kasai:
Criterion values for multiplex SNP genotyping by the Invader assay. Forensic Science
International: Genetics, 4:130-136, 2010
1044. J.-H. Park, T. Nishidate, Y. Nakamura, and T. Katagiri: Critical roles of T-LAK cell-originated
protein kinase in cytokinesis. Cancer Science, 101:403-411, 2010
1045. N. Sato, J. Koinuma, T. Ito, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daogo: Activation of an
oncogenic TBC1D7 (TBC1 Domain Family, Member 7) protein in pulmonary carcinogenesis.
1046. Y. Kamatani, K. Matsuda, M. Kubo, N. Hosono, Y. Daigo, Y. Nakamura, and N. Kamatani:
Genome-wide association study of hematological and biochemical traits in a Japanise population.
1047. M. Inoue, S. Senju, S. Hirata, Y. Ikuta, Y. Hayashida, A. Irie, M. Harao, K. Imai, Y. Tomita, T.
Tsunoda, Y. Furukawa, T. Ito, Y. Nakamura, H. Baba, and Y. Nishimura: Identification of SPARC
as a candidate target antigen for immunotherapy of various cancers.
International Journal of
Cancer, 127:1393-1403, 2010
1048. S. Maeda, M. Kobayashi, S. Araki, T. Babazono, B. I. Freedman, M. A. Bostrom, J. N. Cooke, M.
Toyoda, T. Umezono, L. Tarnow, T. Hansen, P. Gaede, A. Jorsal, D. P K Ng, M. Ikeda, T.
Yanagimoto, T. Tsunoda, H. Unoki, K. Kawai, M. Imanishi, D. Suzuki, H. D. Shin, K. S. Park, A.
Kashiwagi, Y. Iwamoto, K. Kaku, R. Kawamori, H.-H. Parving, D. W. Bowden, O. Pedersen, and
Y. Nakamura: A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta
gene is associated with proteinuria in patients with type 2 Diabetes. PLoS Genetics,
6:e1000842, 2010
1049. J.-H. Park, T. Nishidate, K. Kijima, T. Ohashi, K. Takegawa, T. Fujikane, K. Hirata, Y. Nakamura,
and T. Katagiri: Critical roles of mucin1 glycosylation by transactivated polypeptide
N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis. Cancer Research,
70:2759-2769, 2010
1050. H. Mototani, A. Iida, Y. Nakamura, and S. Ikegawa: Identification of sequence polymorphisms in
CALM2 and analysis of association with hip osteoarthritis in a Japanese population. Journal of
Bone and Mineral Metabolism, 28:547-553, 2010
1051. N.J. Prescott, K.M. Dominy, M. Kubo, C.M. Lewis, S.A. Fisher, R. Redon, N. Huang, B.E.
Stranger, K. Blaszczyk, B. Hudspith, G. Parkes, N. Hosono, K. Yamazaki, C.M. Onnie, A. Forbes,
E.T. Dermitzakis, Y. Nakamura, J.C. Mansfield, J. Sanderson, M.E. Hurles, R.G. Roberts, and
C.G. Mathew: Independent and population-specific association of risk variants at the IRGM locus
with Crohn's disease. Human Molecular Genetics, 19:1828-1839, 2010
1052. S. Hayami, M. Yoshimatsu, A. Veerakumarasivam, M. Unoki, Y. Iwai, T. Tsunoda, H.I. Field, J.D.
Kelly, D.E. Neal, H. Yamaue, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Overexpression of
the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation
of cancer cells through the E2F/RB pathway. Molecular Cancer, 9:59-73, 2010
1053. R. Takayama, H. Nakagawa, A. Sawaki, N. Mizuno, H. Kawai, M. Tajika, Y. Yatabe, K. Matsuo,
R. Uehara, K. Ono, Y. Nakamura, and K. Yamao: Serum tumor antigen REG4 a diagnostic
biomarker in pancreatic ductal adenocarcinoma. Journal of Gastroenterology, 45:52-59, 2010
1054. K. Yasuno, K. Bilguvar, P. Bijlenga, S.-K. Low, B. Krischek, G. Auburger, M. Simon, D. Krex, Z.
Arlier, N. Nayak, Y.M. Ruigrok, M. Niemela, A. Tajima, M. Fraunberg, T. Doczi, F. Wirjatijasa, A.
Hata, J. Blasco, A. Oszvald, H. Kasuya, G. Zilani, B. Schoch, P. Singh, C. Stuer, R. Risselada, J.
Beck, S. Teresa, F. Ricciardi, A. Aromaa, T. Illig, S. Schreiber, C.M. van Duijn, L.H. van den Berg,
C. Perret, C. Proust, C. Roder, A.K. Ozturk, E. Gaal, D. Berg, C. Geisen, C.M. Friedrich, P.
Summers, A.F. Frangi, M.W. State, H.E. Wichmann, M.M.B. Breteler, C. Wijmenga, S. Mane, L.
Peltonen, V. Elio, M.CJM. Sturkenboom, P. Lawford, J. Byrne, J. Macho, I.E. Sandalcioglu, B.
Meyer, A. Raabe, D. Rufenacht, J.E. Jaaskelainen, J. Hernesniemi, G.J.E. Rinkel, H. Zembutsu, I.
Inoue, A. Palotie, F. Cambien, Y. Nakamura, R.P. Lifton, and M. Gunel: Genome-wide
association study of intracranial aneurysm identifies three new risk loci. Nature Genetics,
42:420-425, 2010
1055. M. Nakajima, A. Takahashi, I. Kou, C. Rodriguez-Fontenla, J.J. Gomez-Reino, T. Furuichi, J.
Dai, A. Sudo, A. Uchida, N. Fukui, M. Kubo, N. Kamatani, T. Tsunoda, K.N. Malizos, A. Tsezou, A.
Gonzalez, Y. Nakamura, and S. Ikegawa: New sequence variants in HLA class Ⅱ/Ⅲ region
associated with susceptibility to knee osteoarthritis identified by genome-wide association study.
PLoS ONE, 5:e9723, 2010
1056. S. Hayami, J. D. Kelly, H.-S. Cho, M. Yoshimatsu, M. Unoki, T. Tsunoda, H.I. Field, D.E. Neal, H.
Yamaue, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Overexpression of LSD1 contributes
to human carcinogenesis through chromatin regulation in various cancers. International Journal
of Cancer, 128:574-586, 2010
1057. The International Cancer Genome Consortium: International network of cancer genome projects.
Nature, 464:993-998, 2010
1058. K. Yamaguchi, M. Sakai, T. Shimokawa, Y. Yamada, Y. Nakamura, and Y. Furukawa:
C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer. British
1059. K. Kashiwaya, H. Nakagawa, M. Hosokawa, Y. Mochizuki, L. Piao, S. Chung, K. Ueda, R.
Hamamoto, H. Eguchi, H. Ohigashi, O. Ishikawa, C. Janke, Y. Shinomura, and Y. Nakamura:
Involvement of tublin tyrosine ligase-like family member 4 polyglutamylase in PELP1
polyglutamylation and chromatin remodeling in pancreatic cancer cells. Cancer Research,
70:4024-4033, 2010
1060. N. Akuta, F. Suzuki, M. Hirakawa, Y. Kawamura, H. Yatsuji, H. Sezaki, Y. Suzuki, T. Hosaka, M.
Kobayashi, M. Kobayashi, S. Saitoh, Y. Arase, K. Ikeda, K. Chayama, Y. Nakamura, and H.
Kumada: Amino acid substitution in hepatitis C virus core region and genetic variation near the
interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.
Hepatology, 52:421-429, 2010
1061. N. Phasukkijwatana, B. Kunhapan, J. Stankovich, W. L. Chuenkongkaew, R. Thomson, T.
Thornton, M. Bahlo, T. Mushiroda, Y. Nakamura, S. Mahasirimongkol, A. W. Tun, C. Srisawat, C.
Limwongse, C. Peerapittayamongkol, T. Sura, W. Suthammarak, and P. Lertrit: Genome-wide
linkage scan and association study of PARL to the expression of LHON families in Thailand.
1062. A. Ramamoorthy, D. A. Flockharta, N. Hosono, M. Kubo, Y. Nakamura, and T. C. Skaar:
Differential quantification of CYP2D6 gene copy number by four different quantitative real-time
PCR assays. Pharmacogenetics and Genomics, 20:451-454, 2010
1063. Y. Kochi, Y. Okada, A. Suzuki, K. Ikari, C. Terao, A. Takahashi, K. Yamazaki, N. Hosono, K.
Myouzen, T. Tsunoda, N. Kamatani, T. Furuichi, S. Ikegawa, K. Ohmura, T. Mimori, F. Matsuda,
T. Iwamoto, S. Momohara, H. Yamanaka, R. Yamada, M. Kubo, Y. Nakamura, and K. Yamamoto:
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nature
Genetics, 42:515-519, 2010
1064. K. Kiyotani, T. Mushiroda, N. Hosono, T. Tsunoda, M. Kubo, F. Aki, Y. Okazaki, K. Hirata, Y.
Takatsuka, M. Okazaki, S. Ohsumi, T. Yamakawa, M. Sasa, Y. Nakamura, and H. Zembutsu:
Lessons for pharmacogenomics studies; association study between CYP2D6 genotype and
tamoxifen response. Pharmacogenetics and Genomics, 20:565-568, 2010
1065. H. Abe, H. Ochi, T. Maekawa. C.N. Hayes, M. Tsuge. D. Miki, F. Mitsui, N. Hiraga, M. Imamura,
S. Takahashi, W. Ohishi, K. Arihiro, M. Kubo, Y. Nakamura, and K. Chayama: A common
variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected
hepatitis C virus patients. Journal of Hepatology, 53:439-443, 2010
1066. C. Tanikawa, Y. Nakamura, and K. Matsuda: Crosstalk of EDA-A2/XEDAR in the p53
signaling pathway. Molecular Cancer Research, 8:855-863, 2010
1067. Y. Onouchi, K. Ozaki, J.C. Buns, C. Shimizu, H. Hamada, T. Honda, M. Terai, A. Honda, T.
Takeuchi, S. Shibuta, T. Suenaga, H. Suzuki, K. Higashi, K. Yasukawa, Y. Suzuki, K. Sasago, Y.
Kemmotsu, S. Takatsuki, T. Saji, T. Yoshikawa, T. Nagai, K. Hamamoto, F. Kishi, K. Ouchi, Y.
Sato, J. W. Newburger, A. L. Baker, S. T. Shulman, A. H. Rowley, M. Yashiro, Y. Nakamura, K.
Wakui, Y. Fukushima, A. Fujino, T. Tsunoda, T. Kawasaki, A. Hata, Y. Nakamura, and T. Tanaka:
Common variants in CASP3 confer susceptibility to Kawasaki disease. Human Molecular
Genetics, 19:2898-2906, 2010
1068. K. Yokomine, S. Senju, T. Nakatsura, A. Irie, Y. Hayashida, Y. Ikuta, M. Harao, K. Imai, H. Baba,
H. Iwase, H. Nomori, K. Takahashi, Y. Daigo, T. Tsunoda, Y. Nakamura, Y. Sasaki, and Y.
Nishimura: The forkhead box M1 transcription factor as a candidate of target for anti-cancer
immunotherapy. International Journal of Cancer, 126:2153-2163, 2010
1069. M.-H. Nguyen, J. Koinuma, K. Ueda, T. Ito, E. Tsuchiya, Y. Nakamura, and Y. Daigo:
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein
kinase play a crucial role in human lung carcinogenesis. Cancer Research, 70:5337-5347, 2010
1070. C. Fukukawa, K. Ueda, T. Nishidate, T. Katagiri, and Y. Nakamura: Critical roles of
LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells. Genes
1071. N. Sato, T. Yamabuki, A. Takano, J. Koinuma, M. Aragaki, K. Masuda, N. Ishikawa, N. Kohno, H.
Ito, M. Miyamoto, H. Nakayama, Y. Miyagi, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo:
Wnt Inhibitor dickkopf-1 as a target for passive cancer immunotherapy. Cancer Research,
70:5326-5336, 2010
1072. Y. Harada, M. Kanehira, Y. Fujisawa, R. Takata, T. Shuin, T. Miki, T. Fujioka, Y. Nakamura, and
T. Katagiri: Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression
and oncogenicity in bladder cancer cells. Cancer Research, 70:5829-5839, 2010
1073. S. Uno, H. Zembutsu, A. Hirasawa, A. Takahashi, M. Kubo, T. Akahane, D. Aoki, N. Kamatani,
K. Hirata, and Y. Nakamura: A genome-wide association study identifies genetic variants in the
CDKN2BAS locus associated with endometriosis in Japanese. Nature Genetics, 42:707-710,
2010
1074. M. Uemura, S. Honma, S. Chung, R. Takata, M. Furihata, K. Nishimura, N. Nonomura, Y. Nasu,
T. Miki, T. Shuin, T. Fujioka, A. Okuyama, Y. Nakamura, and H. Nakagawa: 5αDH-DOC
(5α-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate
1075. H. Akaza, K. Kawai, T. Tsukamoto, T. Fujioka, Y. Tomita, T. Kitamura, S. Ozono, T. Miki, S.
Naito, H. Zembutsu, and Y. Nakamura: Successful outcomes using combination therapy of
interleukin-2 and interferon-α for renal cell carcinoma patients with lung metastasis. Japanese
Journal of Clinical Oncology, 40:684-689, 2010
1076. K. Ueda, S. Takami, N. Saichi, Y. Daigo, N. Ishikawa, N. Kohno, M. Katsumata, A. Yamane, M.
Ota, T.-A. Sato, Y. Nakamura, and H. Nakagawa: Development of serum glycoproteomic profiling
technique; simultaneous identification of glycosylation sites and site-specific quantification of
glycan structure changes. Molecular and Cellular Proteomics, 9:1819-1828, 2010
1077. J.N. Ingle, D.J. Schaid, P.E. Goss, M. Liu, T. Mushiroda, J.-A.W. Chapman, M. Kubo, G.D.
Jenkins, A. Batzler, L. Shepherd, J. Pater, L. Wang, M.J. Ellis, V. Stearns, D.C. Rohrer, M.P.
Goetz, K.I. Pritchard, D.A. Flockhart, Y. Nakamura, and R.M. Weinshilboum: Genome-wide
associations and functional genomic studies of musculoskeletal adverse events in women
receiving aromatase inhibitors. Journal of Clinical Oncology, 28:4674-4682, 2010
1078. Y. Okada, Y. Kamatani, A. Takahashi, K. Matsuda, N. Hosono, H. Ohmiya, Y. Daigo, K.
Yamamoto, M. Kubo, Y. Nakamura, and N. Kamatani: Common variations in PSMD3-CSF3 and
PLCB4 are associated with neutrophil count. Human Molecular Genetics, 19:2079-2085, 2010
1079. Y. Okada, Y. Kamatani, A. Takahashi, K. Matsuda, N. Hosono, H. Ohmiya, Y. Daigo, K.
Yamamoto, M. Kubo, Y. Nakamura, and N. Kamantani: A genome-wide association study in 19
633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Human Molecular
Genetics, 19:2303-2312, 2010
1080. R. Takata, S. Akamatsu, M. Kubo, A. Takahashi, N. Hosono, T. Kawaguchi, T. Tsunoda, J.
Inazawa, N. Kamatani, O. Ogawa, T. Fujioka, Y. Nakamura, and H. Nakagawa: Genome-wide
association study identifies five new susceptibility loci for prostate cancer in the Japanese
1081. J.-W. Kim, C. Fukukawa, K. Ueda, T. Nishidate, T. Katagiri, and Y. Nakamura: Involvement of
C12orf32 overexpression in breast carcinogenesis. International Journal of Oncology, 37:861-867,
2010
1082. M. Nakashima, S. Chung, A. Takahashi, N. Kamatani, T. Kawaguchi, T. Tsunoda, N. Hosono, M.
Kubo, Y. Nakamura, and H. Zembutsu: A genome-wide association study identifies four
susceptibility loci for keloid in Japanese population. Nature Genetics, 42:768-771, 2010
1083. A. Iida, T. Kamei, M. Sano, S. Oshima, T. Tokuda, Y. Nakamura, and S. Ikegawa: Large-scale
screening of TARDBP mutations in amyotrophic lateral sclerosis in Japanese. Neurobiology of
Aging, Jul 30. [Epub ahead of print]:, 2010
1084. S.-K. Low, A. Kuchiba, H. Zembutsu, A. Saito, A. Takahashi, M. Kubo, Y. Daigo, N. Kamatani, S.
Chiku, H. Totsuka, S. Ohnami, H. Hirose, K. Shimada, T. Okusaki, T. Yoshida, Y. Nakamura, and
H. Sakamoto: Genome-wide association study of pancreatic cancer in Japanese population.
PLoS ONE, 5:e11824, 2010
1085. H. Ochi, T. Maekawa, H. Abe, Y. Hayashida, R. Nakano, M. Kubo, T. Tsunoda, C.N. Hayes, H.
Kumada, Y. Nakamura, and K. Chayama: ITPA polymorphism affects ribavirin-induced anemia
and outcome of therapy - a genome-wide study of Japanese HCV patients. Gastroenterology,
139:1190-1197, 2010
1086. O. Mizumori, H. Zembutsu, Y. Kato, T. Tsunoda, F. Miya, T. Morizono, T. Tsukamoto, T. Fujioka,
Y. Tomita, T. Kitamura, S. Ozono, T. Miki, S. Naito, H. Akaza, and Y. Nakamura: Identification of
a set of genes associated with response to interleukin-2 and interferon-α combination therapy for
renal cell carcinoma through genome-wide gene expression profiling. Experimental and
Therapeutic Medicine, 1:955-961, 2010
1087. M. Ajiro, T. Nishidate, T. Katagiri, and Y. Nakamura: Critical involvement of RQCD1 in the
EGFR-Akt pathway in mammary carcinogenesis. International Journal of Oncology,
37:1085-1093, 2010
1088. D. Miki, M. Kubo, A. Takahashi, K.-A. Yoon, J. Kim, G.-K. Lee, J.I. Zo, J.S. Lee, N. Hosono, T.
Morizono, T. Tsunoda, N. Kamatani, K. Chayama, T. Takahashi, J. Inazawa, Y. Nakamura, and Y.
Daigo: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and
Korean population. Nature Genetics, 42:893-896, 2010
1089. K. Myouzen, Y. Kochi, K. Shimane, K. Fujio, T. Okamura, Y. Okada, A. Suzuki, T. Atsumi, S. Ito,
K. Takada, A. Mimori, S. Ikegawa, R. Yamada, Y. Nakamura, and K. Yamamoto: Regulatory
polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.
Human Molecular Genetics, 19:2313-2320, 2010
1090. T. Yamauchi, K. Hara, S. Maeda, K. Yasuda, A. Takahashi, M. Horikoshi, M. Nakamura, H.
Fujita, N. Grarup, S Cauchi, D. Ng, R. Ma, T. Tsunoda, M. Kubo, H. Watada, H. Maegawa, M.
Okada-Iwabu, M. Iwabu, N. Shojima, H.D. Shin, G. Andersen, D.R. Witte, T. Jorgensen, T.
Lauritzen, A. Sandbaek, T. Hansen, T. Ohshige, S. Omori, I. Saito, K. Kaku, H. Hirose, W.-Y. So,
D. Beury, J. Chan, K.S. Park, S. Tai, C. Ito, Y. Tanaka, A. Kashiwagi, R. Kawamori, M. Kasuga, P.
Froguel, O. Pedersen, N. Kamatani, Y. Nakamura, and T. Kadowaki: A genome-wide association
study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and
C2CD4A-C2CD4B. Nature Genetics, 42:864-868, 2010
1091. S. Akamatsu, R. Takata, K. Ashikawa, N. Hosono, N. Kamatani, T. Fujioka, O Ogawa, M. Kubo,
Y. Nakamura, and H. Nakagawa: A functional variant in NKX3.1 associated with prostate cancer
susceptibility down-regulates NKX3.1 expression. Human Molecular Genetics, 19:4265-4272,
2010
1092. Y. Okada, A. Suzuki, R. Yamada, Y. Kochi, K. Shimane, K. Myouzen, M. Kubo, Y. Nakamura,
and K. Yamamoto: HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in
Japanese patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 69:1569-1570,
2010
1093. P.-C. Cha, T. Mushiroda, A. Takahashi, M. Kubo, S. Minami, N. Kamatani, and Y. Nakamura:
Genome-wide association study identifies genetic determinants of warfarin responsiveness for
Japanese. Human Molecular Genetics, 19:4735-4744, 2010
1094. S. Maeda, S. Araki, T. Babazono, M. Toyoda, T. Umezono, K. Kawai, M. Imanishi, T. Uzu, H.
Watada, D. Suzuki, A. Kashiwagi, Y. Iwamoto, K. Kaku, R. Kawamori, and Y. Nakamura:
Replication study for the association between four loci identified by a genome-wide association
study on European American subjects with type 1 diabetes and susceptibility to diabetic
nephropathy in Japanese subjects with type 2 diabetes. Diabetes, 59:2075-2079, 2010
1095. N. Kumasaka, Y. Yamaguchi-Kabata, A. Takahashi, M. Kubo, Y. Nakamura, and N. Kamatani:
Establishment of a standardized system to perform population structure analyses with limited
sample size or with different sets of SNP genotypes. Journal of Human Genetics, 55:525-533,
2010
1096. N. Stefanou, V. Papanikolaou, Y. Furukawa, Y. Nakamura, and A. Tsezou: Leptin as a critical
regulator of hepatocellular carcinoma development through modulation of human telomerase
reverse transcriptase. BMC Cancer, 10:442, 2010
1097. Y. Yamaguchi-Kabata, T. Tsunoda, A. Takahashi, N. Hosono, M. Kubo, Y. Nakamura, and N.
Kamatani: Making a haplotype catalog with estimated frequencies based on SNP homozygotes.
1098. A. Fujimoto, H. Nakagawa, N. Hosono, K. Nakano, T. Abe, K.A. Boroevich, M. Nagasaki, R.
Yamaguchi, T. Shibuya, M. Kubo, S. Miyano, Y. Nakamura, and T. Tsunoda: Whole-genome
sequencing and comprehensive variant analysis of a Japanese individual using massively parallel
sequencing. Nature Genetics, 42:931-936, 2010
1099. K.-A. Yoon, J.H. Park, J. Han, S. Park, G.K. Lee, J.-Y. Han, J.I. Zo, J. Kim, J.E. Lee, A.
Takahashi, M. Kubo, Y. Nakamura, and J.S. Lee: A genome-wide association study reveals
susceptibility variants for non-small cell lung cancer in the Korean population. Human Molecular
Genetics, 19:4948-4954, 2010
1100. T. Matsushita, K. Ashikawa, K. Yonemoto, Y. Hirakawa, J. Hata, H. Amitani, Y. Doi, T. Ninomiya,
T. Kitazono, S. Ibayashi, M. Iida, Y. Nakamura, Y. Kiyohara, and M. Kubo: Functional SNP of
ARHGEF10 confers risk of atherothrombotic stroke. Human Molecular Genetics, 19:1137-1146,
2010
1101. T. Matsushita, J. Umeno, Y. Hirakawa, K. Yonemoto, K. Ashikawa, H. Amitani, T, Ninomiya, J.
Hata, Y. Doi, T. Kitazono, M. Iida, Y. Nakamura, Y. Kiyohara, and M. Kubo: Association study of
the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese
1102. I.P.M. Tomlinson, M. Dunlop, H. Campbell, B. Zanke, S. Gallinger, T. Hudson, T. Koessler, P.D.
Pharoah, I. Niittyma¨kix, S. Tuupanenx, L.A. Aaltonen, K. Hemminki, A. Lindblom, A. Fo¨ rsti, O.
Sieber, L. Lipton, T. van Wezel, H. Morreau, J.T. Wijnen, P. Devilee, K. Matsuda, Y. Nakamura, S.
Castellvı´-Bel, C. Ruiz-Ponte, A. Castells, A. Carracedo, J.W.C. Ho, P. Sham, R.M.W. Hofstra, P.
Vodicka, H. Brenner, J. Hampe, C. Schafmayer, J. Tepel, S. Schreiber, H. Vo¨ lzke, M.M. Lerch,
C.A. Schmidt, S. Buch, V. Moreno, C.M. Villanueva, P. Peterlongo, P. Radice, M.M. Echeverry, A.
Velez, L. Carvajal-Carmona, R. Scott, S. Penegar, P. Broderick, A. Tenesa, and R.S. Houlston:
COGENT (COlorectal cancer GENeTics): an international consortium to study the role of
polymorphic variation on the risk of colorectal cancer. British Journal of Cancer, 102:447-454,
2010
1103. M. Unoki, Y. Daigo, J. Koinuma, E. Tsuchiya, R. Hamamoto, and Y. Nakamura: UHRF1 is
a novel diagnostic marker of lung cancer. British Journal of Cancer, 103:217-222, 2010
1104. N. Hosono, S. Chantarangsu, K. Kiyotani, S. Takata, Y. Tsuchiya, S. Mahasirimongkol, W.
Chantratita, T. Mushiroda, Y. Nakamura, and M. Kubo: Development of new HLA-B*3505
genotyping method using Invader assay Pharmacogenetics and Genomics, 10:630-633, 2010
1105. N. Kumasaka, Y. Nakamura, and N. Kamatani: The textile plot: A new linkage disequilibrium
display of multiple-single nucleotide polymorphism genotype data. Plos ONE, 5:e10207, 2010
1106. K. Shimane, Y. Kochi, T. Horita, K. Ikari, H. Amano, M. Hirakata, A. Okamoto, R. Yamada, K.
Myouzen, A. Suzuki, M. Kubo, T. Atsumi, T. Koike, Y. Takasaki, S. Momohara, H. Yamanaka, Y.
Nakamura, K. Yamamoto:
The Association of a Nonsynonymous Single-Nucleotide
Polymorphism in TNFAIP3 With Systemic Lupus Erythematosus and Rheumatoid Arthritis in the
Japanese Population. Arthritis & Rheumatism, 62:574-579, 2010
1107. M. Sakashita, T. Hirota, M. Harada, R. Nakamichi, T. Tsunoda, Y. Osawa, A. Kojima, M.
Okamoto, D. Suzuki, S. Kubo, Y. Imoto, Y. Nakamura, M. Tamari, and S. Fujieda: Prevalence of
allergic rhinitis and sensitization to common aeroallergens in a Japanese population. International
Archives of Allergy and Immunology, 151:255-261, 2010
1108. H. Koriyama, H. Nakagami, T. Katsuya, K. Sugimoto, H. Yamashita, Y. Takami, S. Maeda, M.
Kubo, A. Takahashi, Y. Nakamura, T. Ogihara, H. Rakugi, Y. Kaneda, R. Morishita:
Identification of evidence suggestive of an association with peripheral arterial disease at the
OSBPL10 locus by genome-wide investigation in the Japanese population. Journal of
Atherosclerosis and Thrombosis, 17:1054-1062, 2010
1109. T. Seo, R. Konda, J. Sugimura, K. Iwasaki, Y. Nakamura, and T. Fujioka: Expression of
hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting
therapy. Oncology Letters, 1:697-701, 2010
1110. Y. Kobayashi, Y. Niwa, M. Tajika, H. Kawai, S. Kondo, K. Hara, N. Mizuno, S. Hijioka, A. Sawaki,
K. Matsuo, H. Nakagawa, Y. Nakamura, and K. Yamao: Serum tumor antigen REG4 as a useful
diagnostic biomarker in gastric cancer. Hepato-gastroenterology, 58:1631-1634, 2010
1111. K. Hotta, M. Nakamura, T. Nakamura, T. Matsuo, Y. Nakata, S. Kamohara, N. Miyatake, K.
Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, M. Yoneda, A. Nakajima, T. Funahashi, S.
Miyazaki, K. Tokunaga, M. Kawamoto, H. Masuzaki, T. Ueno, K. Hamaguchi, K. Tanaka, K.
Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, Y.
Nakamura, and Kamatani: Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and
MC4R and their effect on visceral fat area in the Japanese population. Journal of Human
Genetics, 55:738-742, 2010
1112. T. Ohshige, Y. Tanaka, S. Araki. T. Babazono, M. Toyoda, T. Umezono, H. Watada, D. Suzuki,
Y. Iwamoto, R. Kawamori, Y. Nakamura and S. Maeda: A single nucleotide polymorphism in
KCNQ1 is associated with susceptibility to diabetic nephropathy in Japanese subjects with type 2
diabetes. Diabetes Care, 33:842-846, 2010
1113. H. Akaza, T. Tsukamoto, T. Fujioka, Y. Tomita, T. Kitamura, S. Ozono, T. Miki, S. Naito, H.
Zembutsu, and Y. Nakamura: Combined immunotherapy with low-dose IL-2 plus IFN-alpha for
metastatic renal cell carcinoma: survival benefit for selected patients with lung metastasis and
serum sodium level. Japanese Journal of Clinical Oncology, 41:1023-1030, 2011
1114. O.L.J. Peerbooms, J. van Os, M. Drukker, G. Kenis, L. Hoogveld, MTHFR in Psychiatry Group,
M. de Hert, P. Delespaul, R. van Winkel, and B.P.F. Rutten: Methylenetetrahydrofolate
reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: A
combined analysis of independent samples American Journal of Medical Genetics,
156:10.1002/ajmg.b.31160 , 2011
1115. H.-S. Cho, T. Suzuki, N. Dohmae, S. Hayami, M. Unoki, M. Yoshimatsu, G. Toyokowa, M.
Takawa, T. Chen, J. K. Kurash, H.I. Field, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto:
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle
progression in cancer cells. Cancer Research, 71:655-660, 2011
1116. R. Cui, Y. Okada, S.G. Jang, J.L. Ku, J.G. Park, Y. Kamatani, N. Hosono, T. Tsunoda, V. Kumar,
C. Tanikawa, N. Kamatani, R. Yamada, M. Kubo, Y. Nakamura, and K. Matsuda: Common
variant in 6q26-q27 is associated with distal colon cancer in Asian population. Gut, 60:799-805,
2011
1117. K. Imai, S. Hirata, A. Irie, S. Senju, Y. Ikuta, K. Yokomine, M. Harao, M. Inoue, Y. Tomita, T.
Tsunoda, H. Nakagawa, Y. Nakamura, H. Baba, and Y. Nishimura: Identification of
HLA-A2-restricted CTL epitopes of a novel tumor-associated antigen, KIF20A, overexpressed in
pancreatic cancer. British Journal of Cancer, 104:300-307, 2011
1118. A. Iida, N. Hosono, M. Sano, T. Kamei, S. Oshima, T. Tokuda, M. Kubo, Y. Nakamura, and S.
Ikegawa: Optineurin mutations in Japanese amyotrophic lateral sclerosis. Journal of Neurology,
Neurosurgery & Psychiatry, Jan 8. [Epub ahead of print]:, 2011
1119. T. Ozeki, T. Mushiroda, A. Yowang, A. Takahashi, M. Kubo, Y. Shirakata, Z. Ikezawa, M. Iijima,
T. Shiohara, K. Hashimoto, N. Kamatani, and Y. Nakamura: Genome-wide association study
identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous
adverse drug reactions in Japanese population. Human Molecular Genetics, 20:1034-1041,
2011
1120. Y. Fujimoto, H. Ochi, T. Maekawa, H. Abe, C.N. Hayes, H. Kumada, Y. Nakamura, and K.
Chayama: A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1
influences the interferon therapy in hepatitis C patients. Journal of Hepatology, 54:629-639,
2011
1121. Y. Hashimoto, H. Ochi, H. Abe, Y. Hayashida, M. Tsuge, F. Mitsui, N. Hiraga, M. Imamura, S.
Takahashi, C.N. Hayes, W. Ohishi, M. Kubo, T. Tsunoda, N. Kamatani, Y. Nakamura, and K.
Chayama: Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese
patients infected with hepatitis C virus genotype 1b. Journal of Medical Virology, 83:981-988,
2011
1122. F. Suzuki, Y. Suzuki, N. Akuta, H. Sezaki, M. Hirakawa, Y. Kawamura, T. Hosaka, M. Kobayashi,
S. Saito, Y. Arase, K. Ikeda, M. Kobayashi, K. Chayama, N. Kamatani, Y. Nakamura, Y.
Miyakawa, and H. Kumada: Influence of ITPA polymorphism on decreases of hemoglobin during
treatment with pegylated IFN, ribavirin and telaprevir. Hepatology, 53:415-421, 2011
1123. T. Kawaoka , C.N. Hayes, W. Ohishi, H. Ochi, T. Maekawa, H. Abe, M. Tsuge, F. Mitsui, N.
Hiraga, M. Imamura, S. Tkakahashi, M. Kubo, T. Tsunoda, Y. Nakamura, H. Kumada, and K.
Chayama: Predictive value of IL28B polymorphism on the effect of interferon therapy in chronic
hepatitis C patients with genotypes 2a and 2b. Journal of Hepatology, 54:408-414, 2011
1124. A. Aoki, K. Ozaki, H. Sato, A. Takahashi, M. Kubo, Y. Sakata, Y. Onouchi, T. Kawaguchi, T.-H.
Lin, H. Takano, M. Yasutake, P.-C. Hsu, S. Ikegawa, N. Kamatani, T. Tsunoda, S.-H. H. Juo, M.
Hori, I. Komuro, K. Mizuno, Y. Nakamura, and T. Tanaka: SNPs on chromosome 5p15.3
associated with myocardial infarction in Japanese population. Journal of Human Genetics,
56:47-51, 2011
1125. M. Yoshimatsu, G. Toyokawa, S. Hayami, M. Unoki, T. Tsunoda, H.I. Field, J.D. Kelly, D.E. Neal,
Y. Maehara, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Dysregulation of PRMT1 and
PRMT6, type I arginine methyltransferases, is involved in various types of human cancers.
International Journal of Cancer, 128:562-573, 2011
1126. C.N. Hayes, M. Kobayashi, N. Akuta, F. Suzuki, H. Kumada, H. Abe, D. Miki, M. Imamura, H.
Ochi, N. Kamatani, Y. Nakamura, and K. Chayama:
HCV substitutions and IL28B
polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.
Gut,
60:261-267, 2011
1127. P. Saetre, M. Vares, T. Werge, O.A. Andreassen, T. Arinami, H. Ishiguro, S. Nanko, E.C. Tan, D.
H. Han, J. Roffman, J.-W. Muntjewerff, P.P. Jagodzinski, B. Kempisty, J. Hauser, E. Vilella, E.
Betcheva, Y. Nakamura, B. Regland, I. Agartz, H. Hall, L. Terenius, and E.G. Jönsson:
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of
onset in schizophrenia: a combined analysis of independent samples. Neuropsychiatric Genetics,
156:215-224, 2011
1128. S. Chung, H. Nakagawa, M. Uemura, L. Piao, K. Ashikawa, N. Hosono, R. Takata, S. Akamatsu,
T. Kawaguchi, T. Morizono, T. Tsunoda, Y. Daigo, K. Matsuda, N. Kamatani, Y. Nakamura, and
M. Kubo: Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility.
Cancer Science, 102:245-252, 2011
1129. L. Piao, H. Nakagawa, K. Ueda, S. Chung, K. Kashiwaya, H. Eguchi, H. Ohigashi, O. Ishikawa,
Y. Daigo, K. Matsuda, and Y. Nakamura: C12orf48, termed PARP-1 binding protein (PARPBP),
enhances poly (ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells
from DNA damage. Genes Chromosomes and Cancer, 50:13-24, 2011
1130. A. Iida, A. Takahashi, M. Deng, Y. Zhang, J. Wang, N. Atsuta, F. Tanaka, T. Kamei, M. Sano, S.
Oshima, T. Tokuda, M. Morita, C. Akimoto, M. Nakajima, M. Kubo, N. Kamatani, I. Nakano, G.
Sobue, Y. Nakamura, D. Fan, and S. Ikegawa: Replication analysis of SNPs on 9p21.2 and
19p13.3 with amyotrophic lateral sclerosis in East Asians. Neurobiology of Aging, 32:757.e13-14,
2011
1131. Y. Tomita, K. Imai, S. Senju, A. Irie, M. Inoue, Y. Hayashida, K. Shiraishi, T. Mori, Y. Daigo, T.
Tsunoda, T. Ito, H. Nomori, Y. Nakamura, H. Kohrogi, and Y. Nishimura: A novel
tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T lymphocytes reactive
to tumor cells. Cancer Science, 102:697-705, 2011
1132. J.-H. Park, T. Katagiri, S. Chung, K. Kijima, and Y. Nakamura:
Polypeptide
N-acetylgalactosaminyltransferase 6 (GALNT6) disrupts mammary acinar morphogenesis
through O-glycosylation of fibronectin. Neoplasia, 13:320-326, 2011
1133. Y. Kato, H. Zembutsu, R. Takata, F. Miya, T. Tsunoda, W. Obara, T. Fujioka, and Y. Nakamura:
Predicting response of bladder cancers to gemcitabine and carboplatin neoadjuvant
chemotherapy through genome-wide gene expression profiling. Experimental and Therapeutic
Medicine, 2:47-56, 2011
1134. H. Zembutsu, M. Sasa, K. Kiyotani, T. Mushiroda, and Y. Nakamura: Should CYP2D6 inhibitors
be administered in conjunction with tamoxifen? Expert Review of Anticancer Therapy, 11:185-193,
2011
1135. S. Maeda, D. Koya, S. Araki, T. Babazono, T. Umezono, M. Toyoda, K. Kawai, M. Imanishi, T.
Uzu, D. Suzuki, H. Maegawa, A. Kashiwagi, Y. Iwamoto, and Y. Nakamura: Association between
single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy
in Japanese subjects with type 2 diabetes. Clinical Experimental Nephrology, 15:381-390, 2011
1136. K. Okamoto, K. Tokunaga, K. Doi, T. Fujita, H. Suzuki, T. Katoh, T. Watanabe, N. Nishida, A.
Mabuchi, A. Takahashi, M. Kubo, S. Maeda, Y. Nakamura, and E. Noiri: Common variation in
GPC5 is associated with acquired nephrotic syndrome. Nature Genetics, 43:459-463, 2011
1137. T.A. Johnson, Y. Niimura, H. Tanaka, Y. Nakamura, and T. Tsunoda: hzAnalyzer: Detection,
quantification, and visualization of contiguous homozygosity in high-density genotyping datasets.
Genome Biology, 12:R21[Epub ahead of print], 2011
1138. K.G. Tantisira, J. Lasky-Su, M. Harada, A. Murphy, A.A. Litonjua, B.E. Himes, C. Lange, R.
Lazarus, J. Sylvia, B. Klanderman, Q.L. Duan, W. Qiu, T. Hirota, F.D. Martinez, D. Mauger, C.
Sorkness, S. Szefler, S.C. Lazarus, R.F. Lemanske Jr, S.P. Peters, J.J. Lima, Y. Nakamura,
M. Tamari, and S.T. Weiss: Genome-wide association of GLCCI1 with asthma steroid treatment
response. New Eng. J. Med., 365:1173-1183, 2011
1139. V. Kumar, N. Kato, K. Urabe, A. Takahashi, R. Muroyama, N. Hosono, M. Otsuka, R. Tateishi, M.
Omata, H. Nakagawa, K. Koike, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda:
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular
carcinoma. Nature Genetics, 43:455-458, 2011
1140. P.-C. Cha, A. Takahashi, N. Hosono, S.-K. Low, N. Kamatani, M. Kubo, and Y. Nakamura: A
genome-wide association study identifies three loci associated with susceptibility to uterine
fibroids. Nature Genetics, 43:447-450, 2011
1141. F. Nyberg, B.J. Barratt, T. Mushiroda, A. Takahashi, A. Jawaid, S. Hada, T. Umemura, M.
Fukuoka, K. Nakata, Y. Ohe, H. Kato, S. Kudoh, R. March, Y. Nakamura, and N. Kamatani:
Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer:
genome-wide analysis of genetic data. Pharmacogenomics , 12:965-975, 2011
1142. V. Kumar, K. Matsuo, A. Takahashi, N. Hosono, T. Tsunoda, N. Kamatani, S.-Y. Kong, H.
Nakagawa, R. Cui, C. Tanikawa, M. Seto, Y. Morishima, M. Kubo, Y. Nakamura, and K. Matsuda:
Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Journal of
1143. Y. Okada, T. Hirota, Y. Kamatani, A. Takahashi, H. Ohmiya, N. Kumasaka, K. Higasa, Y.
Yamaguchi-Kabata, N. Hosono, M.A. Nalls, M.H. Chen, F.J.A. van Rooij, A.V. Smith, T. Tanaka,
D.J.Couper, N.A. Zakai, L. Ferrucci, D.L. Longo, D.G. Hernandez, J.C.M. Witteman, T.B. Harris,
C.J. O'Donnell, S.K. Ganesh, K. Matsuda, T. Tsunoda, T. Tanaka, M. Kubo, Y. Nakamura, M.
Tamari, K. Yamamoto, and N. Kamatani: Identification of nine novel loci associated with white
blood cell subtypes in a Japanese population. PLoS Genetics, 7:e1002067, 2011
1144. K. Ueda, N. Saichi, S. Takami, D. Kang, A. Toyama, Y. Daigo, N. Ishikawa, N. Kohno, K.
Tamura, T. Shuin, A. Yamane, M. Ota, T. Sato, Y. Nakamura, and H. Nakagawa: A
comprehensive peptidome profiling technology for the identification of early detection biomarkers
for lung adenocarcinoma. PLoS ONE, 6:e18567, 2011
1145. A. Toyama, H. Nakagawa, K. Matsuda, N. Ishikawa, N. Kohno, Y. Daigo, T. Sato, Y. Nakamura,
and K. Ueda: Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum
biomarker discovery of lung cancer. Proteome Science, 9:18, 2011
1146. M. Takawa, K. Masuda, M. Kunizaki, Y. Daigo, K. Takagi, Y. Iwai, H.-S. Cho, G. Toyokawa, Y.
Yamane, K. Maejima, H.I. Field, T. Kobayashi, T. Akasu, M. Sugiyama, E. Tsuchiya, Y. Atomi,
B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Validation of the histone methyltransferase
EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker.
Cancer Science, 102:1298-1305, 2011
1147. I. Kou, A. Takahashi, T. Urano, N. Fukui, H. Ito, K. Ozaki, T. Tanaka, T, Hosoi, M. Shiraki, S.
Inoue, Y. Nakamura, N. Kamatani, M. Kubo, S. Mori, and S. Ikegawa: Common variants in a
novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. PLoS ONE,
6:e19641, 2011
1148. M.A. Nalls, D.J. Couper, T. Tanaka, F.J.A. van Rooij, M-H. Chen, A.V. Smith, D. Toniolo, N.A.
Zakai, Q. Yang, A. Greinacher, A.R. Wood, M. Garcia, P. Gasparini, Y. Liu, T. Lumley, A.R.
Folsom, A.P. Reiner, C. Gieger, V. Lagou, J.F. Felix, H. Völzke, N.A. Gouskova, A. Biffi, A. Döring,
U. Völker, S. Chong, K.L. Wiggins, A. Rendon, A. Dehghan, M. Moore, K. Taylor, J.G. Wilson, G.
Lettre, A. Hofman, J.C. Bis, N. Pirastu, C.S. Fox, C. Meisinger, J. Sambrook, S. Arepalli, M.
Nauck, H. Prokisch, J. Stephens, N.L. Glazer, L.A. Cupples, Y. Okada, A. Takahashi, Y.
Kamatani, K. Matsuda, T. Tsunoda, T. Tanaka, M. Kubo, Y. Nakamura, K. Yamamoto, N.
Kamatani, M. Stumvoll, A. Tönjes, I. Prokopenko, T. Illig, K.V. Patel, S.F. Garner, B. Kuhnel, M.
Mangino, B.A. Oostra, S.L. Thein, J. Coresh, H.-E. Wichmann, S. Menzel, J. Lin, G. Pistis, A.G.
Uitterlinden, T.D. Spector, A. Teumer, G. Eriksdottir, V. Gudnason, S. Bandinelli, T. Frayling, A.
Chakravarti, C.M. van Duijn, D. Melzer, W.H. Ouwehand, D. Levy, E. Boerwinkle, A.B. Singleton,
D.G. Hernandez, D.L. Longo, N. Soranzo, J.C.M. Witteman, B.M. Psaty, L. Ferrucci, T.B. Harris,
C.J. O'Donnell, and S.K. Ganesh: Multiple loci are associated with white blood cell phenotypes.
PLoS Genetics, 7:e1002113, 2011
1149. C. Terao, R. Yamada, K. Ohmura, M. Takahashi, T. Kawaguchi, Y. Kochi, Human Disease
Genomics Working Group, RA Clinical and Genetic Study Consortium, Y. Okada, Y. Nakamura, K.
Yamamoto, I. Melchers, M. Lathrop, T. Mimori, and F. Matsuda: The human AIRE gene at
chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in
Japanese population. Human Molecular Genetics, 20:2680-2685, 2011
1150. K. Chayama, C.N. Hayes, H. Abe, D. Miki, H. Ochi, Y. Karino, J. Toyota, Y. Nakamura, N.
Kamatani, H. Sezaki, M. Kobayashi, N. Akuta, F. Suzuki, and H. Kumada: IL28B but not ITPA
polymorphism is predictive of response to peg-interferon, ribavirin and telaprevir triple therapy in
patients with genotype 1 hepatitis C. Journal of Infectious Diseases, 204:84-93, 2011
1151. T. Azakami, C.N. Hayes, H. Sezaki, M. Kobayashi, N. Akuta, F. Suzuki, H. Kumada, H. Abe, D.
Miki, M. Tsuge, M. Imamura, Y. Kawakami, S. Takahashi, H. Ochi, Y. Nakamura, N. Kamatani,
and K. Chayama: Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia
and effect of peg-interferon plus ribavirin therapy. Journal of Medical Virology, 83:1048-1057,
2011
1152. H. Ochi , T. Maekawa, H. Abe, Y. Hayashida, R. Nakano, M. Imamura, N. Hiraga, Y. Kawakami,
S. Aimitsu, J.-H. Kao, M. Kubo, T. Tsunoda, H. Kumada, Y. Nakamura, C.N. Hayes, and K.
Chayama: IL-28B predicts response to chronic hepatitis C therapy - fine-mapping and replication
study in Asian populations. Journal or General Virology, 92:1071-1081, 2011
1153. T. Mushiroda, Y. Nakamura: Personalizing carbamazepine therapy (Review). Genomic
Medicine, 3:28, 2011
1154. S. Chantarangsu, T. Mushiroda, S. Mahasirimongkol, S. Kiertiburanakul, S. Sungkanuparph, W.
Manosuthi, W. Tantisiriwat, A. Charoenyingwattana, T. Sura, A. Takahashi, M. Kubo, N.
Kamatani, W. Chantratita, and Y. Nakamura: Genome-wide association study identifies variations
in 6p21.3 associated with nevirapine-induced rash. Clinical Infectious Diseases, 53:341-348,
2011
1155. G. Toyokawa, K. Masuda, Y. Daigo, H.-S. Cho, M. Yoshimatsu, M. Takawa, S. Hayami, K.
Maejima, M. Chino, H.I. Field, D.E. Neal, E. Tsuchiya, B.A.J. Ponder, Y. Maehara, Y. Nakamura,
and R. Hamamoto: Minichromosome Maintenance Protein 7 is a potential therapeutic target in
human cancer and a novel prognostic marker of non-small cell lung cancer. Molecular Cancer,
10:65, 2011
1156. Y. Srinivasan, M. Sasa, J. Honda, A. Takahashi, S. Uno, N. Kamatani, M. Kubo, Y. Nakamura,
and H. Zembutsu: Genome-wide association study of epirubicin-induced leukopenia in Japanese
patients. Pharmacogenetics and Genomics, 21:552-558, 2011
1157. H.-S. Cho, J. D. Kelly, S. Hayami, G. Toyokawa, M. Takawa, M. Yoshimatsu, T. Tsunoda, H. I.
Field, D. E. Neal, B. A.J. Ponder, Y. Nakamura, and R. Hamamoto: Enhanced expression of
EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1.
Neoplasia, 13:678-684, 2011
1158. T. Tanabe, N. Yamaguchi, K. Matsuda, K. Yamazaki, S. Takahashi, A. Tojo, M. Onizuka, Y.
Eishi, H. Akiyama, J. Ishikawa, T. Mori, M. Hara, K. Koike, K. Kawa, T. Kawase, Y. Morishima, H.
Amano, M. Kobayashi-Miura, T. Kakamu, Y. Nakamura, S. Asano, and Y. Fujita: Association
analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese
population. International Journal of Hematology, :DOI 10.1007/s12185-011-0860-5, 2011
1159. D. Miki, H. Ochi, C.N. Hayes, H. Abe, T. Yoshima, H. Aikata, K. Ikeda,H. Kumada, J. Toyota, T.
Morizono, T. Tsunoda, M. Kubo, Y. Nakamura, N. Kamatani, and K. Chayama: Variation in the
DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C
virus carriers. Nature Genetics, 43:797-800, 2011
1160. T. Hirota, A. Takahashi, M. Kubo, T. Tsunoda, K. Tomita, S. Doi, K. Fujita, A. Miyatake, T.
Enomoto, T. Miyagawa, M. Adachi, H. Tanaka, A. Niimi, H. Matsumoto, I. Ito, H. Masuko, T.
Sakamoto, N. Hizawa, M. Taniguchi, J.J. Lima, C.G. Irvin, S.P. Peters, B.E. Himes, A.A. Litonjua,
K.G. Tantisira, S.T. Weiss, N. Kamatani, Y. Nakamura, and M. Tamari: Genome-wide association
study identifies three new susceptibility loci for adult asthma in the Japanese population. Nature
Genetics, 43:893-896, 2011
1161. S. Arakawa, A. Takahashi, K. Ashikawa, N. Hosono, T. Aoi, M. Yasuda, Y. Oshima, S. Yoshida,
H. Enaida, T. Tsuchihashi, K. Mori, S. Honda, A. Negi, A. Arakawa, K. Kadonosono, Y. Kiyohara,
N. Kamatani, Y. Nakamura, T. Ishibashi, and M. Kubo: Genome-wide association study identifies
two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
1162. A.P. Reiner, G. Lettre, M.A. Nalls, S.K. Ganesh, R. Mathias, M.A. Austin, E. Dean, S. Arepalli, A.
Britton, Z. Chen, D. Couper, J.D. Curb, C.B. Eaton, M. Fornage, S.F.A. Grant, T.B. Harris, D.
Hernandez, N. Kamatani, B.J. Keating, M. Kubo, A. LaCroix, L.A. Lange, S. Liu, K. Lohman, Y.
Meng, E.R. Mohler Ⅲ, S. Musani, Y. Nakamura, C.J. O'Donnell, Y. Okada, C.D. Palmer, G.J.
Papanicolaou, K.V. Patel, A.B. Singleton, A. Takahashi, H. Tang, H.A. Taylor Jr., K. Taylor, C.
Thomson, L.R. Yanek, L. Yang, E. Ziv, A.B. Zonderman, A.R. Folsom, M.K. Evans, Y. Liu, D.M.
Becker, B.M. Snively, and J.G. Wilson: Genome-wide association study of white blood cell
count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network
(COGENT). PLoS Genetics, 7:e1002108, 2011
1163. Y. Okada, A. Takahashi, H. Ohmiya, N. Kumasaka, Y. kamatani, N. Hosono, T. Tsunoda, K.
Matsuda, T. Tanaka, M. Kubo, Y. Nakamura, K. Yamamoto, and N. Kamatani: Genome-wide
association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
1164. A. Iida, A. Takahashi, M. Kubo, S. Saito, N. Hosono, Y. Ohnishi, K. Kiyotani, T. Mushiroda, M.
Nakajima, K. Ozaki, T. Tanaka, T. Tsunoda, S. Oshima, M. Sano, T. Kamei, T. Tokuda, M. Aoki,
K. Hasegawa, K. Mizoguchi, M. Morita , Y. Takahashi, M. Katsuno, N. Atsuta, H. Watanabe, F.
Tanaka, R. Kaji, I. Nakano, N. Kamatani, S. Tsuji, G. Sobue, Y. Nakamura, and S. Ikegawa: A
functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in
Japanese. Human Molecular Genetics, 20:3684-3692, 2011
1165. A. Yosifova, T. Mushiroda, M. Kubo, A. Takahashi, Y. Kamatani, N. Kamatani, D. Stoianov, R.
Vazharova, S. Karachanak, I. Zaharieva, I. Dimova, S. Hadjidekova, V. Milanova, N. Madjirova, I.
Gerdjikov, T. Tolev, N. Poryazova, G. Kirov, M. Owen, M. O'Donovan, D. Toncheva, and Y.
Nakamura: Genome wide association study on bipolar disorder in the Bulgarian population.
Genes, Brain and Behavior, 10:789-797, 2011
1166. H. Mbarek, H. Ochi, Y. Urabe, V. Kumar, M. Kubo, N. Hosono, A. Takahashi, Y. Kamatani, D.
Miki, H. Abe, T. Tsunoda, N. Kamatani, K. Chayama, Y. Nakamura, and K. Matsuda: A
genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese
population. Human Molecular Genetics, 20:3884-3892, 2011
1167. S. Chung, M. Nakashima, H. Zembutsu, and Y. Nakamura: Possible involvement of NEDD4 in
keloid formation; its critical role in fibroblast proliferation and collagen production. Proceedings of
the Japan Academy. Series B-Physical and Biological Sciences, 87:563-573, 2011
1168. M. Aragaki, K. Takahashi, H. Akiyama, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo:
Characterization of a Cleavage Stimulation Factor, 3’ pre-RNA, Subunit 2, 64kDa (CSTF2) as a
therapeutic target for lung cancer. Clinical Cancer Research, 17:5889-5900, 2011
1169. R. Nishino, A. Takano, H. Oshita, N. Ishikawa, H. Akiyama, H. Ito, H. Nakayama, Y. Miyagi, E.
Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Identification of Epstein-Barr virus-induced
gene 3 as a novel serum and tissue biomarker and a therapeutic target for lung cancer. Clinical
1170. K. Masuda, A. Takano, H. Oshita, H. Akiyama, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y.
Daigo: Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer.
1171. J.C. Chambers, W. Zhang, J. Sehm, Y. Nakamura et al. Identification of genetic loci influencing
markers of liver function in man. Nature Genetics, 43:1131-1138, 2011
1172. N. Kumasaka, H. Fujisawa, N. Hosono, Y. Okada, A. Takahashi, Y. Nakamura, M. Kubo, and N.
Kamatani: Platinum CNV: a bayesian gaussian mixture model for genotyping copy number
polymorphisms using SNP array signal intensity data. Genetic Epidemiology, 35:831-844, 2011
1173. K. Kiyotani, T. Mushiroda and Y. Nakamura: Pharmacogenomics of anticonvulsant agents
(review). BioTech International, 22:16-18, 2011
1174. G. Toyokawa, H.-S. Cho, K. Masuda, M. Yoshimatsu, S. Hayami, M. Takawa, Y. Iwai, Y. Daigo,
E. Tsuchiya, T. Tsunoda, H.I. Field, J.D. Kelly, D.E. Neal, Y. Maehara, B.A.J. Ponder, Y.
Nakamura, and R. Hamamoto: The histone lysine methyltransferase Wolf-Hirschhorn Syndrome
Candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Neoplasia, 13:887-898, 2011
1175. J. Li, D. Yang, Y. He, M. Wang, Z. Wen, L. Liu, J. Yao, K. Matsuda, Y. Nakamura, J. Yu, X.
Jiang, S. Sun, Q. Liu, X. Jiang, Q. Song, M. Chen, H. Yang, F. Tang, X. Hu, J. Wang, Y. Chang, X.
He, Y. Chen, and J. Lin: Associations of HLA-DP variants with hepatitis B virus infection in
Southern and Northern Han Chinese populations: A multicenter case-control study. PLoS ONE,
6:e24221, 2011
1176. G. Toyokawa, H.-S. Cho, Y. Iwai, M. Takawa, M. Yoshimatsu, S. Hayami, K. Maejima, N.
Shimizu, H. Tanaka, T. Tsunoda, H. I. Field, J. D. Kelly, D. E. Neal, B.A.J. Ponder, Y. Maehara, Y.
Nakamura, and R. Hamamoto: The histone demethylase JMJD2B plays an essential role in
human carcinogenesis through positive regulation of cyclin-dependent kinase. Cancer Prevention
Research, 4:2051-2061, 2011
1177. M. Imamura, M. Iwata, H. Maegawa, H. Watada, H. Hirose, Y. Tanaka, K. Tobe, K. Kaku, A.
Kashiwagi, R. Kawamori, Y. Nakamura, and S. Maeda: Genetic variants at CDC123/CAMK1D
and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population.
Diabetologia, 54:3071–3077, 2011
1178. T. Ohshige, M. Iwata, S. Omori, Y. Tanaka, H. Hirose, K. Kaku, H. Maegawa, H. Watada, A.
Kashiwagi, R. Kawamori, K. Tobe, T. Kadowaki, Y. Nakamura, and S. Maeda: Association of new
loci identified in European genome-wide association studies with susceptibility to type 2 diabetes
in the Japanese. PLoS ONE, 6:e26911, 2011
1179. C. Gieger, A. Radhakrishnan, A. Cvejic, W. Tang, Y. Nakamura, et al.: New gene functions in
megakaryopoiesis and platelet formation. Nature, 480:201-208, 2011
1180. T. Hirota, H. Saeki, K. Tomita, S. Tanaka, K. Ebe, M. Sakashita, T. Yamada, S. Fujieda, A.
Miyatake, S. Doi, T. Enomoto, N. Hizawa, T. Sakamoto, H. Masuko, T. Sasaki, T. Ebihara, M.
Amagai, H. Esaki, S. Takeuchi, M. Furue, E. Noguchi, N. Kamatani, Y. Nakamura, M. Kubo, and
M. Tamari: Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to
atopic dermatitis: case-control studies. PLoS ONE, 6:e26987, 2011
1181. H. Abe, C. N. Hayes, H. Ochi, M. Tsuge, D. Miki, N Hiraga, M. Imamura, S. Takahashi, M. Kubo,
Y. Nakamura, N. Kamatani, and K. Chayama: Inverse association of IL28B genotype and liver
mRNA expression of genes promoting or suppressing antiviral state. Journal of Medical Virology,
83:1597–1607, 2011
1182. M. Furu, Y. Kajita, S. Nagayama, T. Ishibe, Y. Shima, K. Nishijo, D. Uejima, R Takahashi, T.
Aoyama, T. Nakayama, T Nakamura, Y. Nakashima, M. Ikegawa, S. Imoto, T. Katagiri, Y.
Nakamura, and J. Toguchida: Identification of AFAP1L1 as a prognostic marker for spindle cell
sarcomas. Oncogene, 30:4015-4025, 2011
1183. K. Yasuno, M. Bakırcıoğlu, S.-K. Low, K. Bilgüvar, E. Gaál, Y.M. Ruigrok, M. Niemelä, A. Hata,
P. Bijlenga, H. Kasuya, J.E. Jääskeläinen, D. Krex, G. Auburger, M. Simon, B. Krischek,
A.K.Ozturk, S. Mane, G.J. Rinkel, H. Steinmetz, J. Hernesniemi, K. Schaller, H. Zembutsu, I.
Inoue, A. Palotie, F. Cambien, Y. Nakamura, R.P. Lifton, and M. Günel: Common variant near the
endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proc.
Natl. Acad. Sci. USA, 108:19707-19712, 2011
1184. K. Dabanaka, S.-Y. Chung, H. Nakagawa, Y. Nakamura, T. Okabayashi, T. Sugimoto, K.
Hanazaki, and M. Furihata: PKIB expression strongly correlated with phosphorylated Akt
expression in the breast cancers and also with triple negative breast cancer subtype. Medical
Molecular Morphology, :DOI 10.1007/s00795-011-0565-0, 2011
1185. P.Y. Yew, T. Mushiroda, K. Kiyotani, G.K. Govindasamy, L.F. Yap, S.H. Teo, P.V. Lim, S.
Govindaraju, K. Ratnavelu, C.K. Sam, Y.Y. Yap, A.S. Khoo, K.C. Pua, Y. Nakamura, The
Malaysian NPC Study Group, and C.C. Ng Identification of a functional variant in SPLUNC1
associated with nasopharyngeal carcinoma susceptibility among Malaysian Chinese. Molecular
Carcinognesis, :doi: 10.1002/mc.21857, 2011
1186. K. Nakabayasi, A. Tajima, K. Yamamoto, A. Takahashi, K. Hata, Y. Takashima, M. Koyanagi, H.
Nakaoka, T. Akamizu, N. Ishikawa, S. Kubota, S. Maeda, T. Tsunoda, M. Kubo, N. Kamatani, Y.
Nakamura, T. Sasazuki, S. Shirasawa: Identification of independent risk loci for Graves' disease
within the MHC in the Japanese population. Journal of Human Genetics, 56:772-778, 2011
1187. M. P. Goetz, D.J. Schaid, D.L. Wickerham, S. Safgren, T. Mushiroda, M. Kubo, A. Batzler, J.P.
Costantino, V.G. Vogel, S. Paik, E.E. Carlson, D.A. Flockhart, N. Wolmark, Y. Nakamura, R.M.
Weinshilboum, J.N. Ingle, M.M. Ames: Evaluation of CYP2D6 and efficacy of tamoxifen and
raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and
P2 clinical trials. Clinical Cancer Research, 17:6944-6951, 2011
1188. E. Noguchi, H. Sakamoto, T. Hirota, K. Ochiai, Y. Imoto, M. Sakashita, F. Kurosaka, A.
Akasawa, S. Yoshihara, N. Kanno, Y. Yamada, N. Shimojo, Y. Kohno, Y. Suzuki, M.J. Kang, J.W.
Kwon, S.J. Hong, K. Inoue, Y. Goto, F. Yamashita, T. Asada, H. Hirose, I. Saito, S. Fujieda, N.
Hizawa, T. Sakamoto, H. Masuko, Y. Nakamura, I. Nomura, M. Tamari, T. Arinami, T. Yoshida, H.
Saito, and K. Matsumoto: Genome-wide association study identifies HLA-DP as a susceptibility
gene for pediatric asthma in Asian populations. PLoS Genetics, 7:e1002170, 2011
1189. Y. Okada, K. Yamazaki, J. Umeno, A. Takahashi, N. Kumasaka, K. Ashikawa, T. Aoi, M.
Takazoe, T. Matsui, A. Hirano, T. Matsumoto, N. Kamatani, Y. Nakamura, K. Yamamoto, and M.
Kubo: HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but
reduces risk for Crohn's disease. Gastroenterology, 141:864-871, 2011
1190. N. Hiraga, H. Abe, M. Imamura, M. Tsuge, S. Takahashi, C.N. Hayes, H. Ochi, C. Tateno, K.
Yoshizato, Y. Nakamura, N. Kamatani, and K. Chayama: Impact of viral amino acid substitutions
and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C
virus. Hepatology, 54:764-771, 2011
1191. K. Yamaguchi, M Sakai, J. Kim, S. Tsunesumi, T. Fujii, T. Ikenoue, Y. Yamada, Y. Akiyama, Y.
Muto, R. Yamaguchi, S. Miyano, Y. Nakamura, and Y. Furukawa: MRG-binding protein
contributes to colorectal cancer development. Cancer Science, 102:1486-92, 2011
1192. M. Harada, T. Hirota, T, A. J. Jodo, Y. Hitomi, M. Sakashita, T. Tsunoda, T. Miyagawa, S.
Doi, Satoru, M. Kameda, K. Fujita, A. Miyatake, T. Enomoto, E. Noguchi, H. Masuko, T.
Sakamoto, N. Hizawa, Y. Suzuki, S. Yoshihara, M. Adachi, M. Ebisawa, H. Saito, K. Matsumoto,
T. Nakajima, R. Mathias, N. Rafaels, K. C. B. E. Himes, Q. L. Duan, K. G. Tantisira, S.T. Weiss,
Y. Nakamura, S. F. Ziegler, and T. Tamari:
Thymic stromal lymphopoietin gene promoter
polymorphisms are associated with susceptibility to bronchial asthma American Journal of
Respiratory Cell and Molecular Biology , 44:787-793, 2011
1193. S.-K. Low, H. Zembutsu, A. Takahashi, N. Kamatani, P.-C. Cha, N. Hosono, M. Kubo, K.
Matsuda, and Y. Nakamura: Impact of LIMK1, MMP2 and TNF-alpha variations for intracranial
aneurysm in Japanese population Journal of Human Genetics, 56:211-216, 2011
1194. K. Yamamoto, T. Ishida, K. Nakano, M. Yamagishi, T. Yamochi, Y. Tanaka, Y. Furukawa, Y.
Nakamura, and T. Watanabe: SMYD3 interacts with HTLV-1 Tax and regulates subcellular
localization of Tax Cancer Science, 102:260-266 , 2011
1195. K. Nishimoto, K. Ikari, H. Kaneko, S. Tsukahara, Y. Kochi, K. Yamamoto, Y. Nakamura, Y.
Toyama, A. Taniguchi, H. Yamanaka, and S. Momohara: Association of EMCN with susceptibility
to rheumatoid arthritis in a Japanese population. Journal of Rheumatology, 38::221-228, 2011
1196. Y.Yamanaka, A. Kitano, K. Takao, A. Prasansuklab, T. Mushiroda, K. Yamazaki, T. Kumada,
M. Shibata, Y. Takaoka, T. Awaya, T. Kato, T. Abe, N. Iwata, T. Miyakawa, Y. Nakamura, T.
Nakahata, and T. Heike: Inactivation of fibroblast growth factor binding protein 3 causes
anxiety-related behaviors. Molecular and Cellular Neuroscience, 46:200-212, 2011
1197. N. Saeki, A. Saito, I.J. Choi, K. Matsuo, S. Ohnami, H. Totsuka, S. Chiku, A. Kuchiba, Y.S. Lee,
K.A. Yoon, M.C. Kook, S.R. Park, Y.W. Kim, H. Tanaka, K. Tajima, H. Hirose, F. Tanioka, Y.
Matsuno, H. Sugimura, S. Kato, T. Nakamura, T. Nishina, W. Yasui, K. Aoyagi, H. Sasaki, K.
Yanagihara, H. Katai, T. Shimoda, T. Yoshida, Y. Nakamura, S. Hirohashi, and H. Sakamoto: A
Functional single nucleotide polymorphism in Mucin 1, at chromosome 1q22, determines
susceptibility to diffuse-type gastric cancer. Gastroenterology, 892:892-902, 2011
1198. Y. Kochi, M.M. Thabet, A. Suzuki, Y. Okada, N.A. Daha, R.E.M. Toes, T.W.J. Huizinga, TWJ,
K. Myouzen, M. Kubo, R. Yamada, Y. Nakamura, and K. Yamamoto: PADI4 polymorphism
predisposes male smokers to rheumatoid arthritis. Annals of Rheumatic Diseases, 70:512-515,
2011
1199. J. Umeno, K. Asano, T. Matsushita, T. Matsumoto, Y. Kiyohara, M. Iida, Y. Nakamura, N.
Kamatani, M. Kubo: Meta-analysis of published studies identified eight additional common
susceptibility loci for Crohn's disease and ulcerative colitis. Inflammatory Bowel Diseases,
17:2407-2415, 2011
1200. H. Abe, C.N. Hayes, H. Ochi, T. Maekawa, M. Tsuge, D. Miki, F. Mitsui, N. Hiraga, M. Imamura,
S. Takahashi, M. Kubo, Y. Nakamura, and K. Chayama: IL28 variation affects expression of
interferon stimulated genes and peg-interferon and ribavirin therapy. Journal of Hepatology,
54:1094-1101, 2011
1201. N. Kumasaka, M. Aoki, Y. Okada, A. Takahashi, K. Ozak, T. Mushiroda, T. Hirota, M. Tamari, T.
Tanaka, Y. Nakamura, N. Kamatani, and M. Kubo: Haplotypes with copy number and single
nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese
population。 Plos One, 7:e44507, 2012
1202. H.-S. Cho, G. Toyokawa, Y. Daigo, S. Hayami, K. Masuda, N. Ikawa, Y. Yamane, K. Maejima, M.
Yoshimatsu, T. Tsunoda, H. I. Field, J. D. Kelly, D. E. Neal, B. A.J. Ponder, Y. Maehara, Y.
Nakamura, and R. Hamamoto: The JmjC domain-containing histone demethylase KDM3A Is a
positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1
gene. International Journal of Cancer, 131:179-189, 2012
1203. F. Innocenti, K. Owzar, N.L. Cox, P. Evans, M. Kubo, H. Zembutsu, C. Jiang, D. Hollis, T.
Mushiroda, L. Li, P. Friedman, L. Wang, H. Hurwitz, K.M. Giacomini, H.L. McLeod, R.M. Goldberg,
R.L. Schilsky, H.L. Kindler, Y. Nakamura, and M.J. Ratain: A genome-wide association study of
overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clinical
1204. M. Maimbo, K. Kiyotani, T. Mushiroda, C. Masimirembwa, and Y. Nakamura: CYP2B6 genotype
is a strong predictor of systemic exposure to efavirenz in HIV-infected Zimbabweans. European
Journal of Clinical Pharmacology, 68:267-271, 2012
1205. N. Akuta, F. Suzuki, M. Hirakawa, Y. Kawamura, H. Sezaki, Y. Suzuki, T. Hosaka, M. Kobayashi,
M. Kobayashi, S. Saitoh, Y. Arase, K. Ikeda, K. Chayama, Y. Nakamura, and H. Kumada: Amino
acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment
efficacy to interferon plus ribavirin combination therapy. Intervirology, 55:231-241, 2012
1206. K. Kiyotani, T. Mushiroda, Y. Nakamura, and H. Zembutsu: Pharmacogenomics of tamoxifen:
roles of drug metabolizing enzymes and transporters. Drug Metabolism and Pharmacokinetics,
27:122-131, 2012
1207. J. Koinuma, H. Akiyama, M. Fujita, M. Hosokawa, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y.
Daigo: Characterization of an Opa interacting protein 5 (OIP5) involved in lung and esophageal
1208. K. Kiyotani, S. Uno, T. Mushiroda, A. Takahashi, M. Kubo, N. Mitsuhata, S. Ina, C. Kihara, Y.
Kimura, H. Yamaue, K. Hirata, Y. Nakamura, and H. Zembutsu: Genome-wide association study
identifies four genetic markers for hematological toxicities in cancer patients receiving
gemcitabine therapy. Pharmacogenetics and Genomics, 22:229-235, 2012
1209. Y. Okada, M. Kubo, H. Ohmiya, A. Takahashi, N. Kumasaka, N. Hosono, S. Maeda, W. Wen, R.
Dorajoo, M.-J. Go, W. Zheng, N. Kato, J.-Y. Wu, Q. Lu, the GIANT consortium, T. Tsunoda, K.
Yamamoto, Y. Nakamura, N. Kamatani, and T. Tanaka: Common variants at CDKAL1 and KLF9
are associated with body mass index in East Asian populations. Nature Genetics, 44:302-306,
2012
1210. W. Wen, Y.S. Cho, W. Zheng, R. Dorajoo, Y. Nakamura, et al.: Meta-analysis of genome-wide
association studies in East Asians identifies novel genetic variants associated with body mass
index. Nature Genetics, 44:307-311, 2012
1211. R. Abo, S. Hebbring, Y. Ji, H. Zhu, Z.-B. Zeng, A. Batzler, G. D. Jenkins, J. Biernacka, K. Snyder,
M. Drews, O. Fiehn, B. Fridley, D.Schaid, N. Kamatani, Y. Nakamura, M. Kubo, T. Mushiroda, R.
Kaddurah-Daouk, D. A. Mrazek, and R. M. Weinshilboum: Merging pharmacometabolomics with
pharmacogenomics using “1000 Genomes” SNP imputation: Selective serotonin reuptake
inhibitor response pharmacogenomics. Pharmacogenetics and Genomics, 22:247-253, 2012
1212. H. Nakagawa, S. Akamatsu, R. Takata, A. Takahashi, M. Kubo, and Y. Nakamura: Prostate
cancer genomics, biology, and risk assessment through genome-wide association studies.
Cancer Science, 103:607-613, 2012
1213. K. Kiyotani, T. Mushiroda, T. Tsunoda, T. Morizono, N. Hosono, M. Kubo, Y. Tanigawara, C.K.
Imamura, D.A. Flockhart, F. Aki, K. Hirata, Y. Takatsuka, M. Okazaki, S. Ohsumi, T. Yamakawa,
M. Sasa, Y. Nakamura, and H. Zembutsu: A Genome-wide association study identifies locus at
10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.
1214. H. Yoshioka, S. Yamamoto, H. Hanaoka, Y. Iida, P. Paudya, T. Higuchi, H. Tominaga, N.
Oriuchi, H. Nakagawa, Y. Shiba, K. Yoshida, R. Osawa, T. Katagiri, T. Tsunoda, Y. Nakamura,
and K. Endo: In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy.
Cancer Immunology, Immunotherapy, 61:1211–1220, 2012
1215. C. Tanikawa, Y. Urabe, K. Matsuo, M. Kubo, A. Takahashi, H. Ito, K. Tajima, N. Kamatani,Y.
Nakamura, and K. Matsuda: Genome wide association study identified two susceptible loci for
duodenal ulcer in Japanese population. Nature Genetics, 44:430-441, 2012
1216. Y. Urabe, C. Tanikawa, A. Takahashi, Y. Okada, T. Morizono, T. Tsunoda, N. Kamatani, K.
Kohri, K. Chayama, M. Kubo, Y. Nakamura, and K. Matsuda: Genome-wide association study of
nephrolithiasis in Japanese population identifies novel susceptible loci at 5q35.3, 7p14.3 and
13q14.1. PLoS Genetics, 8:e1002541, 2012
1217. S.-K. Low, A. Takahashi, P.-C. Cha, H. Zembutsu, N. Kamatani, M. Kubo, and Y. Nakamura:
Genome-wide association study for intracranial aneurysm in Japanese population identifies three
candidate susceptible loci and a functional genetic variant at EDNRA. Human Molecular Genetics,
21:2102-2110, 2012
1218. C. Tanikawa, M. Espinosa, A. Suzuki, K. Masuda, K. Yamamoto, E. Tsuchiya, K. Ueda, Y.
Daigo, Y. Nakamura, and K. Matsuda: Regulation of histone modification and chromatin structure
by the p53-PADI4 pathway. Nature Communications, :DOI 10.1038, 2012
1219. P.-C. Cha, H. Zembutsu, A. Takahashi, M. Kubo, N. Kamatani, and Y. Nakamura: A
genome-wide association study (GWAS) identifies SNP in DCC is associated with gallbladder
cancer (GC) in the Japanese population. Journal of Human Genetics, 57:235-237, 2012
1220. S. Akamatsu, R. Takata, C.A. Haiman, A. Takahashi, T. Inoue, M. Kubo, M. Furihata, N.
Kamatani, J. Inazawa, G.K. Chen, L.L. Marchand, L.N. Kolonel, T. Katoh, Y. Yamano, M.
Yamakado, H. Takahashi, H. Yamada, S. Egawa, T. Fujioka, B.E. Henderson, T. Habuchi, O.
Ogawa, Y. Nakamura, and H. Nakagawa: Common variants at 11q12, 10q26 and 3p11.2 are
associated with prostate cancer susceptibility in Japanese. Nature Genetics, 44:426-429, 2012
1221. W.-C. Chang, C.-H. Lee, T. Hirota, L.-F. Wang, S. Doi, A. Miyatake, T. Enomoto, K. Tomita, M.
Sakashita, T. Yamada, S. Fujieda, K. Ebe, H. Saeki, S. Takeuchi, M. Furue, W.-C. Chen, Y.-C.
Chiu, W. P. Chang, C.-H. Hong, E. Hsi, S.-H. H. Juo, H.-S. Yu, Y. Nakamura, and M. Tamari:
ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese
andTaiwanese populations. PLoS ONE, 7:e29387, 2012
1222. W. Osman, Y. Okada, Y. Kamatani, M. Kubo, K. Matsuda, and Y. Nakamura: Association of
common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin
protein and immunoglobulin isotypes in the Japanese population. PLoS ONE, 7:e32683 , 2012
1223. H.H. Nguyen, R. Takata, S. Akamatsu, D. Shigemizu, T. Tsunoda, M. Furihata, A. Takahashi, M.
Kubo, N. Kamatani, O. Ogawa, T. Fujioka, Y Nakamura, and H. Nakagawa: IRX4 at 5p15
suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring
prostate cancer susceptibility. Human Molecular Genetics, 21:2076-2085, 2012
1224. Y. Okada, C. Terao, K. Ikari, Y. Kochi, K. Ohmura, A. Suzuki, T. Kawaguchi, E. Stahl, F.
Kurreman, N. Nishida, H. Ohmiya, K. Myouzen, M. Takahashi, T. Sawada, Y. Nishioka, M.
Yukioka, T. Matsubara, S. Wakitani, R. Teshima, S. Tohma, K. Takasugi, K. Shimada, A.
Murasawa, S. Honjo, K. Matsuo, H. Tanaka, K. Tajima, T. Suzuki, T. Iwamoto, Y. Kawamura, H.
Tanii, Y. Okazaki, T. Sasaki, P.K. Gregersen, L. Padyukov, J. Worthington, K.A. Siminovitch, M.
Lathrop, A. Taniguchi, A. Takahashi, K. Tokunaga, M. Kubo, Y. Nakamura, N. Kamatani, T.
Mimori, R.M. Plenge, H. Yamanaka, S. Momohara, R. Yamada, F. Matsuda, and K. Yamamoto:
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese
1225. W. Jongjaroenpraser, T. Phusantisampan, S. Mahasirimongkol, T. Mushiroda, N. Hirankarn, T.
Snabboon, S. Chanprasertyotin, P. Tantiwong, S. Soonthornpun, P. Rattanapichart, S.
Mamanasiri, T. Himathongkam, B. Ongphiphadhanakul, A. Takahashi, N. Kamatani, M. Kubo,
and Y. Nakamura: A genome-wide association study identifies novel susceptibility loci for
thyrotoxic hypokalemic periodic paralysis. Journal of Human Genetics, 57:301-304, 2012
1226. M. Aoki, N. Hosono, S. Kakata, Y. Nakamura, N. Kamatani, and M. Kubo: New
pharmacogenetic test for detecting HLA-A*31:01 allele using invaderPlus assay.
Pharmacogenetics and Genomics, 22:441-446, 2012
1227. K. Kiyotani, T. Mushiroda, C.K. Imamura, Y. Tanigawara, N. Hosono, M. Kubo, M. Sasa, Y.
Nakamura, and H. Zembutsu: Dose-adjustment study of tamoxifen based on CYP2D6 genotypes
in Japanese breast cancer patients. Breast Cancer Res Treat, 131:137-145, 2012
1228. C. Tanikawa, H. Nakagawa, Y. Furukawa, Y. Nakamura, and K. Matsuda: CLCA2 as a
p53-inducible senescence mediator. Neoplasia, 14:141-147, 2012
1229. Y. Yamaguchi-Kabata, T. Tsunoda, N. Kumasaka, A. Takahashi, N. Hosono, M. Kubo, Y.
Nakamura, and N. Kamatani: Genetic differences in the two main groups of the Japanese
population based on autosomal SNPs and haplotypes. Journal of Human Genetics, 57:326-334,
2012
1230. Y. Onouchi, K. Ozaki, J.C. Burns, C. Shimizu, M. Terai, H. Hamada, T. Honda, H. Suzuki, T.
Suenaga, T. Takeuchi, N. Yoshikawa, Y. Suzuki K. Yasukawa, R. Ebata, K. Higashi, T. Saji, Y.
Kemmotsu, S. Takatsuki, K. Ouchi, F. Kishi, T. Yoshikawa, T. Nagai, K. Hamamoto, Y. Sata, A.
Honda, H. Kobayashi, J. Sato, S. Shibuta, M. Miyawaki, K. Oishi, H. Yamaga, N. Aoyagi, S.
Iwahashi, R. Miyashita, Y. Murata, K. Sasago, A. Takahashi, N. Kamatani, M. Kubo, T. Tsunoda,
A. Hata, Y. Nakamura, T. Tanaka, and Japan Kawasaki Disease Genome Consortium & U.S.
Kawasaki Disease Genetics Consortium: A genome-wide association study identifies three new
loci for Kawasaki disease. Nature Genetics, 44:517-521, 2012
1231. W. Osman, S.-K. Low, A. Takahashi, M. Kubo, and Y. Nakamura: A Genome-wide association
study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open
angle glaucoma. Human Molecular Genetics, 21:2836-2842, 2012
1232. S. Mahasirimongkol, H. Yanai, T. Mushiroda, W. Promphittayarat, S. Wattanapokayakit, J.
Promjai, R. Yuliwulandari, N. Wichukchinda, A. Yowang, N. Yamada, P. Kantipong, A. Takahashi,
M. Kubo, P. Sawanpanyalert, N. Kamatani, Y. Nakamura, and K. Tokunaga: Genome-wide
association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis.
1233. M Liu, L. Wang, T. Bongartz, J.R. Hawse, S.N. Markovic, D.J. Schaid, T. Mushiroda, M. Kubo, Y.
Nakamura, N. Kamatani, P.E. Goss, J.N. Ingle, and R.M. Weinshilboum: Aromatase inhibitors,
estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A)
gene-mediated regulation of cytokine expression. Breast Cancer Research, 9:R41, 2012
1234. M. Imamura, S. Maeda, T. Yamauchi, K. Hara, K. Yasuda, T. Morizono, A. Takahashi, M.
Horikoshi, M. Nakamura, H. Fujita, T. Tsunoda, M. Kubo, H. Watada, H. Maegawa, M.
Okada-Iwabu, M. Iwabu, N. Shojima, T. Ohshige, S. Omori, M. Iwata, H. Hirose, K. Kaku, C. Ito, Y.
Tanaka, K. Tobe, A. Kashiwagi, R. Kawamori, M. Kasuga, N. Kamatani, Diabetes Genetics
Replication and Meta-analysis (DIAGRAM) Consortium, Y. Nakamura, and T. Kadowaki: A single
nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese
populations. Human Molecular Genetics, 21:3042-3049, 2012
1235. P.T. Ellinor, K.L. Lunetta, C.M. Albert, N.L. Glazer, M.D. Ritchie, A.V. Smith, D.E. Arking, M.
Müller-Nurasyid, B.P. Krijthe, S.A. Lubitz, J.C. Bis, M.K. Chung, K. Ozaki, J.D. Roberts, J.G.
Smith, A. Pfeufer, M.F. Sinner, K. Lohman, J. Ding, N.L. Smith, J.D. Smith, M. Rienstra, K.M. Rice,
D.R. Van Wagoner, J.W. Magnani, R. Wakili, S. Clauss, J.I. Rotter, G. Steinbeck, L.J. Launer,
R.W. Davies, M. Borkovich, T.B. Harris, H. Lin, U. Völker, H. Völzke, D.J. Milan, A. Hofman, E.
Boerwinkle, L.Y. Chen, E.Z. Soliman, B.F. Voight, G. Li, A. Chakravarti, M. Kubo, U. Tedrow, L.M.
Rse, P.M. Ridker, D. Conen, T. Tsunoda, T. Furukawa, N. Sotoodehnia, S. Xu, N. Kamatani, D.
Levy, Y. Nakamura, B. Parvez, S. Mahida, K.L. Furie, J. Rosand, R. Muhammad, B.M. Psaty, T.
Meitinger, S. Perz, H.-E. Wichmann, J.C.M. Witteman, W.H.L. Kao, S. Kathiresan, D.M. Roden,
A.G. Uitterlinden, F. Rivadeneira, B. McKnight, M. Sjögren, A.B. Newman, Y. Liu, M.H. Gollob, O.
Melander, T. Tanaka, B.H.C. Stricker, S.B. Felix, A. Alonso, D. Darbar, J. Barnard, D.I. Chasman,
S.R. Heckbert, E.J. Benjamin, V. Gudnason, and S. Kääb: Meta analysis identifies six new
susceptibility loci for atrial fibrillation. Nature Genetics, 44:670-688, 2012
1236. R. Osawa, T. Tsunoda, S. Yoshimura, T. Watanabe, M. Miyazawa, M. Tani, K. Takeda, H.
Nakagawa, Y. Nakamura, and H. Yamaue: Identification of HLA-A24-restricted novel T cell
epitope peptides derived from P-cadherin and kinesin family member 20A. Journal of Biomedicine
and Biotechnology, :doi:10.1155/2012/848042, 2012
1237. M. Takawa, H.-S. Cho, S. Hayami, G. Toyokawa, M. Kogure, Y. Yamane, Y. Iwai, K. Maejima, K.
Ueda, A. Masuda, N. Dohmae, H.I. Field, T. Tsunoda, T. Kobayashi, T. Akasu, M. Sugiyama, S.
Ohnuma, Y. Atomi, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Histone lysine
methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer
Research, 72:3217-3227, 2012
1238. H.-S. Cho, S. Hayami, G. Toyokawa, K. Maejima, Y. Yamane, T. Suzuki, N. Dohmae, M. Kogure,
D. Kang, D.E. Neal, B.A.J. Ponder, H. Yamaue, Y. Nakamura, and R. Hamamoto: RB1
methylation by SMYD2 enhances cell cycle progression through an increase of RB1
phosphorylation. Neoplasia, 14:476-, 2012
1239. A. Fujimoto, Y. Totoki, T. Abe, K. A. Boroevich, F. Hosoda, H. H. Nguyen, M. Aoki, N. Hoshono,
M. Kubo, F. Miya, Y. Arai, H. Takahashi, T. Shirakihara, M. Nagasaki, T. Shibuya, K. Nakano, K.
Watanabe-Makino, H. Tanaka, H. Nakamura, J. Kusuda, H. Ojima, K. Shimada, T. Okusaka, M.
Ueno, Y. Shigekawa, Y. Kawakami, K. Arihiro, H. Ohdan, K. Gotoh, O. Ishikawa, S. Ariizumi, M.
Yamamoto, T. Yamada, K. Chayama, T. Kosuge, H. Yamaue, N. Kamatani, S. Miyano, H.
Nakagama, Y. Nakamura, T. Tsunoda, T. Shibata, and H. Nakagawa: Whole genome sequencing
of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in
chromatin regulators. Nature Genetics, 44:760-764, 2012
1240. W. Obara, R. Ohsawa, M. Kanehira, R. Takata, T. Tsunoda, K. Yoshida, K. Takeda, T. Katagiri,
Y. Nakamura, T. Fujioka: Cancer peptide vaccine therapy developed from ongoantigens that
were identified through genome-wide expression profile analysis for bladder cancer Japanese
Journal of Clinical Oncology, 42:591-600, 2012
1241. K. Okuno, F. Sugiura, K. Itoh, Y. Yoshida, T. Tsunoda, Y. Nakamura: Recent advances in active
specific cancer vaccine threatment for colorectal cancer Current Pharmacology and
Biotechnology, 13:1439-1445, 2012
1242. A. Toyama, A. Suzuki, T. Shimada, C. Aoki, Y. Aoki, Y. Umino, Y. Nakamura, D. Aoki, and TA.
Sato: Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine
aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific
biomarkers. Cancer Science, 103:747-755, 2012
1243. Y. Okada, K. Shimane, Y. Kochi, T. Tahira, A. Suzuki, K. Higasa, A. Takahashi, T. Horita, T.
Atsumi, T. Ishii, A. Okamoto, K. Fujio, M. Hirakata, H. Amano, Y. Kondo, S. Ito, K. Takada, A.
Mimori, K. Saito, M. Kamachi, Y. Kawaguchi, K. Ikari, OW Mohammed, K. Matsuda, C. Terao, K.
Ohmura, K. Myouzen, N. Hosono, T. Tsunoda, N. Nishimoto, T. Mimori, F. Matsuda, Y. Tanaka, T.
Sumida, H. Yamanaka, Y. Takasaki, T. Koike, T. Horiuchi, K. Hayashi, M. Kubo, N. Kamatani, R.
Yamada, Y. Nakamura, and K. Yamamoto: A genome-wide association study identified AFF1 as
a susceptibility locus for systemic lupus eyrthematosus in Japanese. PLoS Genetics, 8:e1002455,
2012
1244. H. Ochi, CN. Hayes, H. Abe, Y. Hayashida, T. Uchiyama, N. Kamatani, Y. Nakamura, and K.
Chayama: Toward the establishment of a prediction system for the personalized treatment of
chronic hepatitis C. Journal of Infectious Diseases, 205:204-210, 2012
1245. Y. Okada, X. Sim, M. J. Go, C.-H. Chen, D. Gu, F. Takeuchi, A. Takahashi, S. Maeda, T.
Tsunoda, P. Chen, S.-C. Lim1, T.-Y Wong, J. Liu1, T. L. Young, T. Aung, M. Seielstad, Y.-Y. Teo,
Y. J. Kim, J.-Y. Lee, B.-G. Han, D. Kang, F.-J. Tsai, L.-C. Chang, S.-J. C. Fann, Y.-T. Chen, H.
Mei, D. C. Rao, J. E. Hixson, S. Chen, T. Katsuya, M. Isono, T. Ogihara, J. C. Chambers, W.
Zhang, J. S. Kooner, the KidneyGen consortium, the CKDGen consortium , E. Albrecht, the
GUGC consortium , K. Yamamoto, M. Kubo, Y. Nakamura, N. Kamatani, N. Kato, J. He, J.-Y. Wu,
Y. S. Cho, E.-S. Tai, and T. Tanaka: Genome-wide meta-analysis identifies multiple loci
associated with kidney function-related traits in east Asian populations. Nature Genetics,
44:904-909, 2012
1246. M.G. Dunlop, S.E. Dobbins, S.M. Farrington, A.M.Jones, C. Palles, N. Whiffin, A. Tenesa, S.
Spain, P. Broderick, L.-Y. Ooi, E. Domingo, C. Smillie, M. Henrion, M. Frampton, L. Martin, G.
Grimes, M. Gorman, C. Semple, Y.P. Ma, E. Barclay, J. Prendergast, J.-B. Cazier, B. Olver, S.
Penegar, S. Lubbe, I. Chander, L.G. Carvajal-Carmona, S. Ballereau, A. Lloyd, J. Vijayakrishnan,
L. Zgaga, I. Rudan, E. Theodoratou, The Colorectal Tumour Gene Identification (CORGI)
Consortium, J.M. Starr, I. Deary, I. Kirac, D. Kovacevi, L.A. Aaltonen, L. Renkonen-Sinisalo, J.-P.
Mecklin, K. Matsuda, Y. Nakamura, Y. Okada, S. Gallinger, D.J. Duggan, D. Conti, P. Newcomb,
J. Hopper, M.A. Jenkins, F. Schumacher, G. Casey, D. Easton, M. Shah, P. Pharoah, A.
Lindblom, T. Liu, The Swedish Low-Risk Colorectal Cancer Study Group, C. G Smith, H. West,
J.P. Cheadle, The COIN Collaborative Group, R. Midgley, D.J. Kerr, H. Campbell, I.P. Tomlinson,
and R.S. Houlston: Common variation near CDKN1A, POLD3 and SHROOM2 influences
colorectal cancer risk. Nature Genetics, 44:770-777, 2012
1247. T. Masuzawa, Y. Fujiwara, K. Okada, A. Nakamura, S. Takiguchi, K. Nakajima, H. Miyata, M.
Yamasaki, Y. Kurokawa, R. Osawa, K. Takeda, K. Yoshida, T. Tsunoda, Y. Nakamura, M. Mori,
and Y. Doki: Phase I/II study of S-1 plus cisplatin combined with peptide vaccines for human
vascular endothelial growth factor receptor 1 and 2 in patients with advanced gastric cancer.
1248. K. Kusakabe, N. Ide, Y. Daigo, T. Itoh, K. Higashino,Y. Okano, G. Tadano, Y. Tachibana, Y.
Sato, M. Inoue, T. Wada, M. Iguchi, T. Kanazawa, Y. Ishioka, K. Dohi, S. Tagashira, Y. Kido, S.
Sakamoto, K. Yasuo, M. Maeda, T. Yamamoto, M. Higaki, T. Endoh, K. Ueda, T. Shiota, H. Murai,
and Y. Nakamura: Diaminopyridine-based potent and selective MPS1 kinase inhibitors binding to
an unusual flipped-peptide conformation. Medical Chemistry Letters, 3:560−564, 2012
1249. T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda, and Y. Nakamura: Critical function for nuclear
envelope protein TMEM209 in human pulmonary carcinogenesis. Cancer Research,
72:4110-4118, 2012
1250. K. Shiraishi, H. Kunitoh, Y. Daigo, A. Takahashi, K. Goto, H. Sakamoto, S. Ohnami, Y. Shimada,
K. Ashikawa, A. Saito, S. Watanabe, K. Tsuta, N. Kamatani, T. Yoshida, Y. Nakamura, J. Yokota,
M. Kubo, and T. Kohno: A genome-wide association study identifies two new susceptibility loci for
lung adenocarcinoma in the Japanese population. Nature Genetics, 44:900-903, 2012
1251. M.-H. Nguyen, K. Ueda, Y. Nakamura, and Y. Daigo: Identification of a novel oncogene
MMS22L involved in lung and esophageal carcinogenesis. International Journal of Oncology,
41:1285-1296, 2012
1252. K. Kono , H. Iinuma, Y. Akutsu, H. Tanaka, N. Hayashi, Y. Uchikado, T. Noguchi, H. Fujii, K.
Okinaka, R. Fukushima, H. Matsubara, M. Ohira, H. Baba, S. Natsugoe, S. Kitano, K. Yoshida, T.
Tsunoda, and Y. Nakamura: Multicenter, Phase II clinical trial of Cancer Vaccination for
Advanced Esophageal cancer with Three Peptides derived from Novel Cancer-Testis Antigens.
Journal of Trasnlational Medicine, 10:141, 2012
1253. B. E. Himes, X. Jiang, R. Hu, A. C. Wu, J. A. Lasky-Su, B. J. Klanderman, J. Ziniti, J.
Senter-Sylvia, J. J. Lima, C. G. Irvin, S. P. Peters, D. A. Meyers, E. R. Bleecker, M. Kubo, M.
Tamari, Y. Nakamura, S. J. Szefler, R. F. Lemanske Jr., R. S. Zeiger, R. C. Strunk, F. D. Martinez,
J. P. Hanrahan, G. H. Koppelman, D. S. Postma, M. A. E. Nieuwenhuis, J. M. Vonk, R. A.
Panettieri Jr., A. Markezich, E. Israel, V. J. Carey, K. G. Tantisira, A. A. Litonjua, Q. Lu, and S. T.
Weiss: Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel
bronchodilator response gene. PLoS Genetics, 8:e1002824, 2012
1254. M. Takahashi, Y. Furukawa, H. Shimodaira, M. Sakayori, T. Moriya, Y. Moriya, Y. Nakamura.
and C. Ishioka: Aberrant splicing caused by a MLH1 splice donor site mutation found in a young
Japanese patient with Lynch syndrome Familial Cancer, 11:559-564, 2012
1255. Y. Ji, J. M. Biernacka, S. Hebbring, Y Chai, G. D. Jenkins, A. Batzler, K. A. Snyder, M. S.
Drews, Z. Desta, D. Flockhart, T. Mushiroda, M. Kubo, Y. Nakamura, N. Kamatani, D. Schaid, R.
M. Weinshilboum and D. A. Mrazek: Pharmacogenomics of selective serotonin reuptake inhibitor
treatment for major depressive disorder: genome-wide associations and functional genomics.
Pharmacogenomics Journal, :doi:10.1038/tpj.2012.32, 2012
1256. R. M. Baldwin, K. Owzar, H. Zembutsu, A. Chhibber, M. Kubo, C. Jiang, D. Watson, R. J. Eclov,
J. Mefford, H. L. McLeod, P. N. Friedman, C. A. Hudis, E. P. Winer, E. M. Jorgenson, J. S. Witte,
L. N. Shulman, Y. Nakamura, M. J. Ratain and D. L. Kroetz: A genome-wide association study
identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
1257. T.Hirota, A. Takahashi, M. Kubo, T. Tsunoda, K. Tomita, M. Sakashita, T. Yamada, S. Fujieda,
S. Tanaka, S. Doi, A. Miyatake, T. Enomoto, C. Nishiyama, N. Nakano, K. Maeda, K. Okumura, H.
Ogawa, S. Ikeda, E. Noguchi, T. Sakamoto, N. Hizawa, K. Ebe, H. Saeki, T. Sasaki, T. Ebihara,
M. Amagai, S. Takeuchi, M. Furue, Y. Nakamura, and M. Tamari: Genome-wide association
study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
1258. V. Kumar, P.H.Y. Lo, H. Sawai, N.Kato, A. Takahashi, Z. Deng, Y. Urabe, H. Mbarek, K.
Tokunaga, Y. Tanaka, M. Sugiyama, M. Mizokami, R. Muroyama, R. Tateishi, M. Omata, K. Koike,
C. Tanikawa, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda Soluble MICA and a MICA
variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma. Plos ONE,
7:e44743, 2012
1259. S. Elgazzar, H. Zembutsu, A. Takahashi, M. Kubo, F. Aki, K. Hirata, Y. Takatsuka, M. Okazaki,
S. Ohsumi, T. Yamakawa, M. Sasa, T. Katagiri, Y. Miki, and Y. Nakamura: A genome-wide
association study identifies a genetic variant in the SIAH2 locus associated with hormonal
receptor
positive
breast
cancer
in
Japanese.
Journal
of
Human
Genetics, :doi:10.1038/jhg.2012.108, 2012
1260. H.-S. Cho, T. Shimazu, G. Toyokawa, Y. Daigo, Y. Maehara, S. Hayami, A. Ito, K. Masuda, N.
Ikawa, H. I. Field, E. Tsuchiya, S. Ohnuma, B. A.J. Ponder, M. Yoshida, Y. Nakamura, and R.
Hamamoto: Enhanced HSP70 lysine 561 methylation promotes proliferation of cancer cells
through activation of aurora kinase B. Nature Communications, 3:DOI: 10.1038/ncomms2074,
2012
1261. S. Akamatsu, A. Takahashi, R. Takata, M. Kubo, T. Inoue, T. Morizono, T. Tsunoda, N.
Kamatani, C. A. Haiman, P. Wan, G. K. Chen, L. Le Marchand, L. N. Kolonel, B. E. Henderson, T.
Fujioka, T. Habuchi, Y. Nakamura, O. Ogawa, and H. Nakagawa: Reproducibility, Performance,
and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese. PLOS
ONE, 7:e46454, 2012
1262. A. Toyama, H. Nakagawa, K. Matsuda, T. Sato, Y. Nakamura, and K. Ueda: Quantitative
structural characterization of local N-glycan microheterogeneity in therapeutic antibodies by
energy-resolved oxonium ion monitoring. Analytical Chemistry, 84:9655-9662, 2012
1263. D.R. Nyholt, S.-K. Low, C.A. Anderson, J.N. Painter, S. Uno, A.P. Morris, S. MacGregor, S.D.
Gordon, A.K. Henders, N.G. Martin, J. Attia, E.G. Holliday, M. McEvoy, R.J. Scott, S.H. Kennedy,
S.A. Treloar, S.A. Missmer, S. Adachi, K. Tanaka, Y. Nakamura, K.T. Zondervan, H. Zembutsu,
and G.W. Montgomery: Multi-ethnic GWA meta-analysis identifies new endometriosis risk loci
1264. K.M. Giacomini, S.W. Yee, M.J. Ratain, R.M. Weinshilboum, N. Kamatani and Y. Nakamura:
Pharmacogenomics and patient care: one size does not fit all. Science Translational Medicine,
4:153ps18, 2012
1265. R. Takata, K. Matsuda, J. Sugimura, W. Obara, T. Fujioka, K. Okihara, N. Takaha, T. Miki, S.
Ashida, K. Inoue, C. Tanikawa, T. Shuin, S. Sasaki, Y. Kojima, K. Kohri, M. Kubo, M. Yamaguchi,
Y. Ohnishi, and Y. Nakamura: Impact of four loci on serum tamsulosin hydrochloride
concentration. Journal of Human Genetics, 58:21-26, 2012
1266. T. Fukawa, M. Ono, T. Matsuo, H. Uehara, T. Miki, Y. Nakamura, H. Kanayama, and T. Katagiri:
DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with
NPM1 in renal cell carcinomas. Cancer Research, 72:5867-5877, 2012
1267. E. Danese, M. Montagnana, J.A. Johnson, A.E. Rettie, C.F. Zambon, S.A. Lubitz, G.
Suarez-Kurtz, L.H. Cavallari, L. Zhao, M. Huang, Y. Nakamura, T. Mushiroda, M.K. Kringen, P.
Borgiani, C. Ciccacci, N.T. Au, T. Langaee, V. Siguret, M.-A. Loriot, H. Sagreiya, R.B. Altman,
M.H.A. Shahin, S.A. Scott, S.I. Khalifa, B. Chowbay, I.M. Suriapranata, M. Teichert, B.H. Stricker,
M. Taljaard, M.R. Botton, J.E. Zhang, M. Pirmohamed, X. Zhang, J.F. Carlquist, B.D. Horne,
M.T.M. Lee, V. Pengo, G.C. Guidi, P. Minuz, and C. Fava: Impact of the CYP4F2 p.V433M
polymorphism on coumarin dose requirement: systematic review and meta-analysis. Clinical
Pharmacology & Therapeutics, 92:746-756, 2012
1268. M. Komatsu, T. Yoshimaru, T. Matsuo, K. Kiyotani, Y. Miyoshi, T. Tanahashi, K. Rokutan, R.
Yamaguchi, A. Saito, S. Imoto, S. Miyano, Y. Nakamura, M. Sasa, M. Shimada, and T. Katagiri:
Molecular features of triple negative breast cancers by genome-wide gene expression profiling
analysis. International Journal of Oncology, :doi: 10.3892/ijo.2012.1744., 2012
1269. N. Franceschini, F.J. van Rooij, B.P. Prins, M.F. Feitosa, Karakas M, Eckfeldt JH, Folsom AR,
Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y,
Polasek O, Westra HJ, Wang YA, Del Greco M F, Glazer NL, Kapur K, Kema IP, Lopez LM,
Schillert A, Smith AV, Winkler CA, Zgaga L; The LifeLines Cohort Study, Bandinelli S, Bergmann
S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L,
Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ,
Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A,
Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang
Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM,
Gieger C, Harris TB, Hicks AA, Koenig W, O'Donnell CJ, Fox CS, Pramstaller PP, Psaty BM,
Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G,
Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF,
Alizadeh BZ, Cupples LA, Perry JR, Morris AP. Discovery and Fine Mapping of Serum Protein
Loci through Transethnic Meta-analysis. Am. J. Human Genetics, 91:744-753, 2012
1270. S. Chung, H. Suzuki, T. Miyamoto, N. Takamatsu, A. Tatsuguchi, K. Ueda, K. Kijima, Y.
Nakamura and Y. Matsuo: Development of an orally-administrative MELK-targeting inhibitor that
suppresses the growth of various types of human cancer Oncotarget, 3:1629-1640, 2012
1271. I. Cheng, G.K. Chen, H. Nakagawa, J. He, P. Wan, C.C. Laurie, J. Shen, X. Sheng, L.C. Pooler,
A.H. Crenshaw, D.B. Mirel, A. Takahashi, M. Kubo, Y. Nakamura, Yusuke)7; A.A. Olama, S.
Benlloch, J.L. Donovan, M. Guy, F.C. Hamdy, Z. Kote-Jarai, D.E. Neal, L.R. Wilkens, K.R.
Monroe, D.O. Stram, K. Muir, R.A. Eeles, D. Easton, L.N. Kolonel, B.E. Henderson, L.
LeMarchand, and C.A. Haiman; Evaluating genetic risk for prostate cancer among Japanese
and Latinos. Cancer Epidemiology Biomarkers & Prevention, 21:2048-2058, 2012
1272. H. Sawai, N. Nishida, H. Mbarak, K. Matsuda, Y. Mawatari, M. Yamaoka, S. Hige, J.H. Kang,
K. Abe, S. Mochida, M. Watanabe, M. Kurosaki, Y. Asahina, N. Izumi, M. Honda, S. Kaneko, E.
Tanaka, K. Matsuura, Y. Itoh, E. Mita, M. Korenaga, K. Hino, Y. Murawaki, Y. Hiasa, T. Ide, K.
Ito, M. Sugiyama, S.H. Ahn, K.H. Han, J.Y. Park, M.F. Yuen, Y. Nakamura, Y. Tanaka, M.
Mizokami, and K. Tokunaga: No association for Chinese HBV-related hepatocellular carcinoma
susceptibility SNP in other East Asian populations. BMC Medical Genetics, 13:DOI:
10.1186/1471-2350-13-47, 2012
1273. A. IIda, N. Hosono, M. Sano, T. Kamei, S. Oshima, T. Tokuda, M. Nakajima, M. Kubo, Y.
Nakamura, and S. Ikegawa, Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in
Japanese: Neurobiology of aging, 8:1.843E+22, 2012
1274. M. Myouzen, Y. Kochi, Y. Okada, C. Terao, A. Suzuki, K. Ikari, T. Tsunoda, A. Takahashi, M.
Kubo, A. Taniguchi, F. Matsuda, K. Ohmura, S. Momohara, T. Mimori, H. Yamanaka, N.
Kamatani, R. Yamada, Y. Nakamura, and K. Yamamoto: Functional variants in NFKBIE and
RTKN2 involved in activation of the NF-kappa B pathway are associated with rheumatoid arthritis
in Japanese. PLos Genetics, 8::e1002949, 2012
1275. A. Köttgen, E. Albrecht, A. Teumer, V. Vitart, J. Krumsiek et al. Genome-wide association
analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics,
45:145-154, 2013
1276. H.E. Wheeler, E.R. Gamazon, C. Wing, U.O. Njiaju, C. Njoku, R.M. Baldwin, K. Owzar, C. Jiang,
D. Watson, I. Shterev, M. Kubo, H. Zembutsu, E. Winer, C. Hudis, L.N. Shulman, Y. Nakamura,
M.J. Ratain, D.L. Kroetz, N.J. Cox, M.E. Dolan for the Cancer and Leukemia Group B:
Integration of cell line and clinical trial genome-wide analyses implicates multiple loci in
paclitaxel-induced peripheral neuropathy.
1277. K. Yamazaki, J. Umeno, A. Takahashi, A. Hirano, T. A. Johnson, N. Kumasaka, T. Morizono, N.
Hosono, T. Kawaguchi, M. Takazoe, T. Yamada, Y. Suzuki, H. Tanaka, S. Motoya, M. Hosokawa,
Y. Arimura, Y. Shinomura, T. Matsui, T. Matsumoto, M. Iida, T. Tsunoda, Y. Nakamura, N.
Kamatani and M. Kubo: A Genome-wide association study Identifies 2 susceptibility loci for
Crohn’s disease in a Japanese population. Gastroenterology, 144:781-788, 2013
1278. E.T. Betcheva, A.G. Yosifova, T. Mushiroda, M. Kubo, A. Takahashi, S.K. Karachanak, I.T.
Zaharieva, S.P. Hadjidekova, I.I. Dimova, R.V. Vazharova, D.S. Stoyanov, V.K. Milanova, T.
Tolev, G. Kirov, N. Kamatani, D.I. Toncheva, and Y. Nakamura: Whole-genome-wide association
study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiatric
Genetics, 23:11-19, 2013
1279. D. Kang, H.-S. Cho, G. Toyokawa, M. Kogure, Y. Yamane, Y. Iwai, S. Hayami, T. Tsunoda, H. I.
Field, K. Matsuda, D. E. Neal, B. A.J. Ponder, Y. Maehara, Y. Nakamura, and R. Hamamoto: The
Histone Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1) Is Involved
in Human Carcinogenesis. Genes Chromosomes and Cancer, 52:126-139, 2013
1280. R. Nakano, T. Maekawa, H. Abe, Y. Hayashida, H. Ochi, T. Tsunoda, H. Kumada, N. Kamatani,
Y. Nakamura and K. Chayama: Single-nucleotide polymorphisms in GALNT8 are associated with
the response to interferon therapy for chronic hepatitis C. Journal of General Virology, 94:81-89,
2013
1281. Y. Kamada, N. Kinoshita , Y. Tsuchiya, K. Kobayashi, H. Fujii, N. Terao, K. Kamihagi, N.
Koyama, S. Yamada, Y. Daigo, Y. Nakamura, N. Taniguchi, E. Miyoshi: Reevaluation of a lectin
antibody ELISA kit for measuring fucosylated haptoglobin in various conditions. Clinica Chimica
Acta, 417:48-53, 2013
1282. K. Shimane, Y. Kochi, A. Suzuki, Y. Okada, T. Ishii, T. Horita, K. Saito, A. Okamoto, N.
Nishimoto, K. Myouzen, M. Kubo, M. Hirakata, T. Sumida, Y. Takasaki, R. Yamada, Y. Nakamura,
N. Kamatani and K. Yamamoto: An association analysis of HLA-DRB1 with systemic lupus
erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on
disease phenotypes. Rheumatology, 52:1172-1182, 2013
1283. Y. Urabe, H. Ochi, N. Kato, V. Kumar1, A. Takahashi, R. Muroyama, N. Hosono3, M. Otsuka, R.
Tateishi, P. H. Y. Lo, C. Tanikawa, M. Omata, K. Koike, D. Miki, H. Abe, N. Kamatani, J. Toyota,
H. Kumada, M. Kubo, K. Chayama, Y. Nakamura, and Koichi Matsuda: A genome-wide
association study of HCV induced liver cirrhosis in the Japanese population identifies novel
susceptibility loci at MHC region. Journal of Hepatology, 58:875-882, 2013
1284. A. Aarnink, H.J. Garchon, Y. Okada, T. Takahashi, K. Matsuda, M. Kubo, Y. Nakamura, and B,
Blancher: Comparative analysis in cynomolgus macaque identifies a novel human MHC locus
controlling platelet blood counts independently of BAK1. Journal of Thrombosis and Haemostasis,
11:384-386, 2013
1285. M. Unoki, A. Masuda, N. Dohmae, K. Arita, M. Yoshimatsu, Y. Iwai, Y. Fukui, K. Ueda, R.
Hamamoto, M. Shirakawa, H. Sasaki, and Y. Nakamura: Lysyl 5-Hydroxylation, a novel histone
modification, by Jumonji domain containing 6 (JMJD6). Journal of Biological Chemistry,
288:6053-6062. , 2013
1286. K. Tomita, M. Sakashita, T. Hirota, S. Tanaka, K. MasuyamaT. Yamada, S. Fujieda, A. Miyatake,
N. Hizawa, M. Kubo, Y. Nakamura, and M. Tamari: Variants in the 17q21 asthma susceptibility
locus are associated with allergic rhinitis in the Japanese population. Allergy, 68:92-100, 2013
1287. Y. Kajita, T. Kato Jr, S. Tamaki, M. Furu, R. Takahashi, S. Nagayama, T. Aoyama, H. Nishiyama,
E. Nakamura, T. Katagiri, Y. Nakamura, O. Ogawa, and J. Toguchida: The transcription factor
Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin
filament-associated protein 1-like 1 (AFAP1L1). PLOS ONE, 8:e49709, 2013
1288. B. E. Himes, K. Sheppard, A. Berndt5, A. S. Leme, R. A. Myers, C. R. Gignoux, A. M. Levin8, W.
J. Gauderman, J. J. Yang, R. A. Mathias, I. Romieu, D. G. Torgerson, L. A. Roth, S. Huntsman, C.
Eng, B. Klanderman, J. Ziniti, J. Senter-Sylvia, S. J. Szefler, R. F. Lemanske, Jr., R. S. Zeiger, R.
C. Strunk, F. D. Martinez, H. Boushey, V. M. Chinchilli, E. Israel, D. Mauger, G. H. Koppelman, D.
S. Postma, M. A. E. Nieuwenhuis, J. M. Vonk, J. J. Lima, C. G. Irvin, S. P. Peters, M. Kubo, M.
Tamari, Y. Nakamura, A. A. Litonjua, K. G. Tantisira, B. A. Raby, E. R. Bleecker, D. A. Meyers, S.
J. London, K. C. Barnes, F. D. Gilliland, L. K. Williams, E. G. Burchard, D. L. Nicolae, C. Ober, D.
L. DeMeo, E. K. Silverman, B. Paigen, G. Churchill, S. D. Shapiro, and S. T. Weiss:
Integration
of Mouse and Human Genome-wide association data identifies KCNIP4 as an asthma gene.
PLOS ONE, 8:e56179, 2013
1289. The AMD Gene Consortium: Seven new loci associated with age-related macular degeneration.
1290. K. Semba, K. Araki, K. Matsumoto, H. Suda, T. Ando, A. Sei, H. Mizuta, K. Takagi, M. Nakahara,
M. Muta, G. Yamada, N. Nakagata, A. Iida, S. Ikegawa, Y. Nakamura, M. Araki, K. Abe, and K.
Yamamura: Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal
malformations in Danforth’s short tail mice. PLOS Genetics, 9:e1003204, 2013
1291. A, Hirano, K. Yamazaki, J. Umeno, K. Ashikawa, M. Aoki, T. Matsumoto, S. Nakamura, T.
Ninomiya, T. Matsui, F. Hirai, T. Kawaguchi, M. Takazoe, H. Tanaka, S. Motoya, Y. Kiyohara, T.
Kitazono, Y. Nakamura, N. Kamatani, and M. Kubo: Associatiion study of 71 European Crohn's
disease susceptibility loci in a Japanese population. Inflammatory Bowel Diseases, 19:526–533,
2013
1292. P.H.Y. Lo, Y. Urabe, V. Kumar, C. Tanikawa, K. Koike, N. Kato, D. Miki, K. Chayama, M. Kubo,
Y. Nakamura, and K. Matsuda: Identification of a functional variant in the MICA promoter which
regulates MICA expression and increases HCV-related hepatocellular carcinoma risk. PLOS
ONE, 8:DOI: 10.1371/journal.pone.0061279, 2013
1293. M. A. Perera, L. H. Cavallari, N. A. Limdi, E. R. Gamazon, A. Konkashbaev, R. Daneshjou,
A. Pluzhnikov, D. C. Crawford, J. Wang,
N. Liu,
N. Tatonetti, S. Bourgeois,
H.
Takahashi, Y. Bradford, B. M. Burkley, R. J. Desnick, J. L. Halperin, S. I. Khalifa, T. Y. Langaee,
S. A. Lubitz, E. A. Nutescu, M. Oetjens, M. H. Shahin, S. R. Patel, H. Sagreiya, M. Tector, K. E.
Weck, M. J. Rieder, S. A. Scott, A. H.B. Wu, J. K. Burmester, M. Wadelius, P. Deloukas, M. J.
Wagner, T. Mushiroda, M. Kubo, D. M. Roden, N. J. Cox, R. B. Altman, T. E. Klein, Y.
Nakamura, J. A. Johnson: Genetic variants associated with warfarin dose in African-American
individuals: a genome-wide association study. Lancet, 382:790-796, 2013
1294. M. Ishihara, N. Araya, T. Sato, A. Utsunomiya, Y. Yamano, Y. Nakamura, H. Nakagawa, and K.
Ueda: Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia. Blood,
121:4340-4347, 2013
1295. M. Liu, J. N. Ingle, B. L. Fridley, A. U. Buzdar, M. E. Robson, M. Kubo, L. Wang, A. Batzler, G. D.
Jenkins, T. L. Pietrzak, E. E. Carlson, M. P. Goetz, D. W. Northfelt, E. A. Perez, C. V. Williard, D.
J. Schaid, Y. Nakamura and R. M. Weinshilboum: TSPYL5 SNPs: Association with Plasma
Estradiol Concentrations and Aromatase Expression. Molecular Endocrinology, 27:657-670, 2013
1296. M. Ratain, Y. Nakamura, and N. J. Cox: CYP2D6 genotype and tamoxifen activity:
Understanding interstudy variability in methodological quality.
Clinical Pharmacology &
Therapeutics, 94:185-187, 2013
1297. C. Tanikawa, C. Tanikawa, Y. Okada, A. Takahashi, K. Oda, N. Kamatani, M. Kubo, Y.
Nakamura, and K. Matsuda: Genome wide association study of age at menarche in the
Japanese population. PLOS ONE, 8:e63821, 2013
1298. M. Kogure, M. Takawa, H.-S. Cho, G. Toyokawa, K. Hayashi, T. Tsunoda, T. Kobayashi, Y.
Daigo, M. Sugiyama, Y. Atomi, Y. Nakamura, and R. Hamamoto: Deregulation of the histone
demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S
transition
Cancer Letters, 336:76-84, 2013
1299. J.N. Ingle, M. Liu, D.L. Wickerham, D.J. Schaid, L. Wang, T. Mushiroda, M. Kubo, J.P.
Costantino, V.G. Vogel, S. Paik, M.P. Goetz, M.M. Ames, G.D. Jenkins, A. Batzler, E.E. Carlson,
D.A. Flockhart, N. Wolmark, Y. Nakamura, and R.M. Weinshilboum: Selective Estrogen Receptor
Modulators and Pharmacogenomic Variation in ZNF423 Regulation of BRCA1 Expression:
Individualized Breast Cancer Prevention Cancer Discovery, 3:812-825, 2013
1300. S. Chung, and Y. Nakamura: MELK inhibitor, novel molecular targeted therapeutics for human
cancer stem cells (editorial) Cell Cycle, 12:1655-1656, 2013
1301. K. Kiyotani, T. Mushirota, H. Zembutsu, and Y. Nakamura: Important and critical scientific
aspects in pharmacogenomics analysis: lessons from controversial results of tamoxifen and
CYP2D6 studies. Journal of Human Genetics, 58:327–333, 2013
1302. S.-K. Low , S. Chung, A. Takahashi, H. Zembutsu, T. Mushiroda, M. Kubo and Y. Nakamura:
Genome-wide
association
study
of
chemotherapeutic
agents-induced
severe
neutropenia/leucopenia for patients in Biobank Japan
Cancer Science, 104:1074-1082, 2013
1303. T. Yasui, A. Okada, Y. Urabe, M. Usami, K. Mizuno, Y. Kubota, K. Tozawa, S. Sasaki, Y.
Higashi, Y. Sato, M. Kubo, Y. Nakamura, K. Matsuda, and K. Kohri: A replication study for 3
nephrolithiasis loci at 5q35.3, 7p14.3, and 13q14.1 in the Japanese population. Journal of Human
Genetics, 58:588-593, 2013
1304. Y. Daigo, A. Takano, K. Teramoto, S. Chung, and Y. Nakamura: A Systematic Approach to the
Development of Novel Therapeutics for Lung Cancer using Genomic Analyses Clinical
Pharmacology & Therapeutics, 94:doi:10.1038/clpt.2013.90, 2013
1305. H. Oshita, R. Nishino, A. Takano, T. Fujitomo, M. Aragaki, T. Kato, H. Akiyama, E. Tsuchiya, N.
Kohno, Y. Nakamura, and Y. Daigo: RASEF is a novel diagnostic biomarker and a therapeutic
target for lung cancer. Molecular Cancer Research, 11:937-951, 2013
1306. Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, Y. Kuroda, M. Hirayama, A. Irie, K. Kawahara, J.
Yatsuda, A. Hamada, H. Jono, K. Yoshida, T. Tsunoda, H. Kohrogi, Y. Yoshitake, Y. Nakamura,
M. Shinohara, and Y. Nishimura; Identification of promiscuous KIF20A long peptides bearing both
CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant
tumor. Clinical Cancer Research, 19:4508-4520, 2013
1307. K. Kusakabe, N. Ide, Y. Daigo, Y. Tachibana, T. Itoh, T. Yamamoto, H. Hashizume, Y. Hato, K.
Higashino, Y. Okano, Y. Sato, M. Inoue, M. Iguchi, T. Kanazawa, Y. Ishioka, K. Dohi, Y. Kido, S.
Sakamoto, K. Yasuo, M. Maeda, M. Higaki, K. Ueda, H. Yoshizawa, Y. Baba, T. Shiota, H. Murai,
and Y. Nakamura: Indazole-based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational
Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125). Journal of Medicinal Chemistry,
56:4343-4356, 2013
1308. H. Saeki, T. Hirota, H. Nakagawa, Y. Tsunemi, T. Kato, S. Shibata, M. Sugaya, S. Sato, S. Doi,
A. Miyatake, K. Ebe, E. Noguchi, T. Ebihara, M. Amagai, H. Esaki, S. Takeuchi, M. Furue, Y.
Nakamura, and M. Tamari: Genetic polymorphisms in the IL22 gene are associated with psoriasis
vulgaris
in
a
Japanese
population.
Journal
of
Dermatological
Science, :doi.org/10.1016/j.jdermsci.2013.04.002, 2013
1309. D. Ellinghaus, H. Baurecht, J. Esparza-Gordillo, E. Rodríguez, A. Matanovic, I. Marenholz, N.
Hübner, H. Schaarschmidt, N. Novak, S. Michel, L. Maintz, T. Werfel, U. Meyer-Hoffert, M. Hotze,
H. Prokisch, K. Heim, C. Herder, T. Hirota, M. Tamari, M. Kubo, A. Takahashi, Y. Nakamura, L. C.
Tsoi, P. Stuart, J.T. Elder, L. Sun, X. Zuo, S. Yang, X. Zhang, P. Hoffmann, M. MNöthen, R.
Fölster-Holst, J. Winkelmann, T. Illig, B. OBoehm, R. H Duerr, C. Büning, S. Brand, J. Glas, M. A.
McAleer, C. M. Fahy, M. Kabesch, S. Brown, W.H.I. McLean, A. DIrvine, S. Schreiber, Y.-A. Lee4,
A. Franke and S. Weidinger: High-density genotyping study identifies four new susceptibility loci
for atopic dermatitis Nature Genetics, :doi:10.1038/ng.2642, 2013
1310. R. Daneshjou, N. P. Tatonetti, K. J. Karczewski, H. Sagreiya, S. Bourgeois, K. Drozda, J. K.
Burmester, T. Tsunoda, Y. Nakamura, M. Kubo, M. Tector, N. A. Limdi, L. H. Cavallari, M. Perera,
J. A. Johnson, T. E Klein and R. B. Altman: Pathway analysis of genome-wide data improves
warfarin dose prediction. BMC Genomics, 14:doi:10.1186/1471-2164-14-S3-S11, 2013
1311. T. Yoshimaru, M. Komatsu, T. Matsuo, Y.-A. Chen, Y. Murakami, K. Mizuguchi, E. Mizohata, T.
Inoue, M. Akiyama, R. Yamaguchi, S. Imoto, S. Miyano, Y. Miyoshi, M. Sasa, Y. Nakamura, and T.
Katagiri: Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer
cells. Nature Communications, 4:DOI: 10.1038/ncomms3443, 2013
1312. S. Chung, S.-K. Low, H. Zembutsu, A. Takahashi, M. Kubo, M. Sasa, and Y. Nakamura: A
genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
Breast Cancer Research, 15:R81, 2013
1313. G. Pare, M. Kubo, J. B. Byrd, C. A. McCarty, A. Woodard-Grice, K. K. Teo, S. S. Anand, R L.
Zuvich, Y. Bradford, S. Ross, Y. Nakamura, M. Ritchie and N. J. Brown: Genetic variants
associated
with
angiotensin-converting
enzyme
inhibitor-associated
angioedema.
Pharmacogenetics and Genomics, 23:470-478, 2013
1314. K. Asano, T. Matsumoto, J. Umeno, A. Hirano, M. Esaki, N. Hosono, T. Matsui, Y. Kiyohara, Y.
Nakamura, M. Kubo, and T. Kitazono: Impact of allele copy number of polymorphisms in
FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis. Inflammatory Bowel Diseases,
19:2061-2068, 2013
1315. M. A. Province, M. P. Goetz, H. Brauch, D. A. Flockhart, J. M. Hebert, R. Whaley, V. J. Suman,
W. Schroth, S. Winter, H. Zembutsu, T. Mushiroda, W. G. Newman, M.-T. M. Lee, C.
B. Ambrosone, M. W. Beckmann, J.-Y. Choi, A.-S. Dieudonné, P. A. Fasching, R. Ferraldeschi,
L. Gong, E. Haschke-Becher, A. Howell, L. B. Jordan, U. Hamann, K. Kiyotani, P. Krippl, D.
Lambrechts, A. Latif, U. Langsenlehner, W. Lorizio, P. Neven, A. T. Nguyen, B.-W. Park, C.
A. Purdie, P. Quinlan, W. Renner, M. Schmidt, M. Schwab, J.-G. Shin, J. C. Stingl, P. Wegman,
S. Wingren, A. H.B. Wu, E. Ziv, G. Zirpoli, A. M. Thompson, V. C. Jordan, Y. Nakamura, R.
B. Altman, M. M. Ames, R. M. Weinshilboum, M. Eichelbaum, J. N. Ingle and T. E. Klein:
CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-analysis of Heterogeneous Study Populations.
Clinical Pharmacology & Therapeutics, 94:doi: 10.1038/clpt.2013.186, 2013
1316. S.-K. Low, A. Takahashi, K. Ashikawa, J. Inazawa, Y. Miki, M. Kubo, Y. Nakamura, and T.
Katagiri: Genome-wide association study of breast cancer in the Japanese population. PLOS
ONE, 8:e76463, 2013
1317. K. Ueda, A. Tatsuguchi, N. Saichi, A. Toyama, K. Tamura, M. Furihata, R. Takata, S. Akamatsu,
M. Igarashi, M. Nakayama, T. Sato, O. Ogawa, T. Fujioka, T. Shuin, Y. Nakamura, and H.
Nakagawa: Plasma low-molecular-weight proteome profiling identified neuropeptide-Y as a
prostate cancer biomarker polypeptide. Journal of Proteome Research, 12:4497-4506, 2013
1318. J. Wang, L. G. Carvajal-Carmona, J.-H. Chu, A. G. Zauber, APC Trial Collaborators, M. Kubo, K.
Matsuda, M. Dunlop, R. S. Houlston, O. M. Sieber, L. Lipton, P. Gibbs, N. G. Martin, G. W.
Montgomery, J. P. Young, P. N. Baird, M. J. Ratain, Y. Nakamura, S. Weiss, I. Tomlinson, and M.
M. Bertagnolli: Germline variants and advanced colorectal adenomas: adenoma Prevention with
Celecoxib Trial Genomewide Association Study. Clinical Cancer Research, 19:6430-6437, 2013
1319. C. M. O’Seaghdha, C. M. O’Seaghdha, H. Wu, Q. Yang, K. Kapur, I. Guessous, A. M. Zuber, A.
Kottgen, C. Stoudmann, A. Teumer, Z. Kutalik, M. Mangino, A. Dehghan, W. Zhang, G.
Eiriksdottir, G. Li, T. Tanaka, L. Portas, L. M. Lopez, C. Hayward, K. Lohman, K. Matsuda, S.
Padmanabhan, D. Firsov, R. Sorice, S. Ulivi, A. C. Brockhaus, M. E. Kleber, A. Mahajan, F. D.
Ernst, V. Gudnason, L. J. Launer, A. Mace, E. Boerwinckle, D. E. Arking, C. Tanikawa, Y.
Nakamura, M. J. Brown, J.-M. Gaspoz, J.-M. Theler, D. S. Siscovick, B. M. Psaty, S. Bergmann,
P. Vollenweider, V. Vitart, A. F. Wright, T. Zemunik, M. Boban, I. Kolcic, P. Navarro, E. M. Brown,
K. Estrada, J. Ding, T. B. Harris, S. Bandinelli, D. Hernandez, A. B. Singleton, G. Girotto, D.
Ruggiero, A. Pio d’Adamo, A. Robino, T. Meitinger, C. Meisinger, G. Davies, J. M. Starr, J. C.
Chambers, B. O. Boehm, B. R. Winkelmann, J. Huang, F. Murgia, S. H. Wild, H. Campbell, A. P.
Morris, O. H. Franco, A. Hofman, A. G. Uitterlinden, F. Rivadeneira, U. Volker, A. Hannemann, R.
Biffar, W. Hoffmann, S.–Y. Shin, P. Lescuyer, H. Henry, C. Schurmann, The SUNLIGHT
consortium, The GEFOS consortium, P. B. Munroe, P. Gasparini, N. Pirastu, M. Ciullo, C. Gieger,
W. Marz, L. Lind, T. D. Spector, A. V. Smith, I. Rudan, J. F. Wilson, O. Polasek, I. J. Deary, M.
Pirastu, L. Ferrucci, Y. Liu, B. Kestenbaum, J. S. Kooner, J. C. M. Witteman, M. Nauck, W. H. L.
Kao, H. Wallaschofski, O. Bonny, C. S. Fox, M. Bochud: Meta-analysis of genome-wide
association studies identifies six new loci for serum calcium concentrations. PLOS Genetics,
9:e1003796, 2013
1320. M. Kogure, M. Kogure, M. Takawa, V. Saloura, K. Sone, L. Piao, K. Ueda, R. Ibrahim, T.
Tsunoda, M. Sugiyama, Y. Atomi, Y. Nakamura and R. Hamamoto: The oncogenic polycomb
histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes
ubiquitination.
Neoplasia, 11:1251-1261, 2013
1321. E.R. Behr, M.D. Ritchie, T. Tanaka, S. Kaab, D.C. Crawford, P. Nicoletti, A. Floratos, M.F.
Sinner, P.J. Kannankeril, A.A.M. Wilde, C.R. Bezzina, E. Schulze-Bahr, S. Zumhagen, P.
Guicheney, N.H. Bishopric, V. Marshall, S. Shakir, C. Dalageorgou, S. Bevan, Y. Jamshidi, R.
Bastiaenen, R.J. Myerburg, J.-J. Schott, A.J. Camm, G. Steinbeck, K. Norris, R.B. Altman, N.P.
Tatonetti, S. Jeffery, M. Kubo, Y. Nakamura, Y. Shen, A.L. George, Jr., and D.M. Roden:
Genome wide analysis of drug-Induced Torsades de Pointes: Lack of common variants with large
effect sizes. PLOS ONE, 8:e78511, 2013
1322. D. Miki, H. Ochi, A. Takahashi, C.N. Hayes, Y. Urabe, H. Abe, T. Kawaoka, M. Tsuge, N. Hiraga,
M. Imamura, Y. Kawakami, H. Aikata, S. Takahashi, N. Akuta, F. Suzuki, K. Ikeda, H. Kumada, Y.
Karino, J. Toyota, T. Tsunoda, M. Kubo, N. Kamatani, Y. Nakamura, and K. Chayama:
HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: A genome-wide
association study Plos ONE, 8e84226, 2013
1323. D. Kroetz, A. Chhibber, J. Mefford, E. Stahl, S. Pendergrass, R. Baldwin, K. Owzar, M. Li, E.
Winer, C. Hudis, H. Zembutsu, M. Kubo, Y. Nakamura, H. McLeod, M. Ratain, L. Shulman, M.
Ritchie, R. Plenge, and J. Witte: Polygenic inheritance of paclitaxel-induced sensory peripheral
neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
The
Pharmacogenomics Journal, in press, 2014
1324. Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, S. Yoshimura, R. Osawa, Y. Kuroda, M. Hirayama,
A. Irie, A. Hamada, H. Jono, K.Yoshida, T. Tsunoda, H. Kohrogi, Y. Yoshitake, Y. Nakamura, M.
Shinohara, and Y. Nishimura: Identification of CDCA1 long peptides bearing both CD4+ and
CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients. International
Journal of Cancer, 134:352–366, 2014
1325. S. Yoshimura, T. Tsunoda, R. Osawa, M. Harada, T. Watanabe, T. Hikichi, M. Katsuda, M.
Miyazawa, M. Tani, M. Iwahashi, K. Takeda, T. Katagiri, Y. Nakamura, and H. Yamaue:
Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2
(HIG2). PLoS ONE, 9:e85267, 2014
1326. K. Yamaguchi, R. Yamaguchi, N. Takahashi, T. Ikenoue, T. Fujii, M. Shinozaki, G. Tsurita, K.
Hata, A. Niida, S. Imoto, S. Miyano, Y. Nakamura, and Y. Furukawa: Overexpression of Cohesion
Establishment Factor DSCC1 through E2F in Colorectal Cancer. PLoS ONE, 9:e85750, 2014

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