Lucia Regina Ribiero

Micronutrient Genomics Project & Human Variome Project
Latin American Contribution
Lucia Regina Ribeiro, PhD
State University of São Paulo, UNESP, SP, Brazil
Latin American Nutrigenomics Organisation - LANUGO
1
Map of undernutrition in the world
2
Global Multiple Micronutrient Deficiencies
> 3 billion people afflicted
(Map from USAID)
3
B
4
Some strategies to alleviate the vitamin and mineral deficiencies
in Latin America.
Iterventions programs: Recomendations
Functional food
RDA (Recomended Daily Alloance)
Fortified food
One size does not fit all
Supplements
Inter individual genetic variation
Interethnic genetic variation
5
Genetic Diversity in Brazilian Population
6
Genetic ancestry analysis of 3 Brazilians supposed to be of
“African origin”
Luiz Antônio Marcondes – Neguinho da
Beija Flor- Singer (from Rio de Janeiro – Southeast)
67.1% European genes
31.5% African genes
1.4% Amerindian genes
Ildi Silva – Actress (from Bahia – Northeast)
71.3% European genes
19.5% African genes
9.3% Amerindian genes
Daiane dos Santos – Olympic Gymnastic champion
(from Rio Grande do Sul – South)
40.8% European genes
39.7% African genes
19.6% Amerindian genes
Pena, S.D, 2007. Raizes Afro-Brasileiras, BBC Brasil
7
North
Northeast
61% European
62% European
12% African
34% African
27% Amerindian
4% Amerindian
72% European
20% African
Southeast
8% Amerindian
92% European
8% African
South
Santos and Guerreiro, 1995;
Dornelles et al., 1999
0% Amerindian
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Genetic ancestry admixture proportions (%) of populations in
10 countries of Latin-America*
Euramerindian
Argentina
Bolívia
15.0
Amerindian
Others
Habitants
(miillion)
85.0
7.4
7.6
38.9
15.0
55.0
15.0
8.5
0.3
0.5
193.0
3.0
2.0
16.0
1.0
4.0
3.0
44.9
European
African
4.5
Afroeuropean
Brazil
64.0
30.7
Chile
95.0
Costa Rica
80.0
4.0
15.0
10.0
4.0
Colombia
58.0
20.0
Mexico
60.0
25.0
15.0
Peru
37.0
15.0
45.0
Cuba
66.0
9.0
23.0
Uruguay
88.0
4.0
8.0
5.0
109.0
3.0
27.6
2.0
11.4
3.3
*Data obtained from Statistical Institute from each Country (last census).
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Latin American contribution to MICRONUTRIEN GENOMICS PROJECT (MGP)
Three actions are in development :
1.
Workshop: Where Nutrigenomics science is going: Some experiences
1.1. Latin American contribution: Argentina, Brazil, Bolivia, Costa Rica, Chile, Colombia,
México, etc. (What they are doing or intent to do?)
1.2. Experiences: Australia, NuGo, FDA, MGP-MICROGENNET
During International Conference on Nutrigenomics (INCON), September 26-29,
010,Brazil
2.
Fellowships Doctoral Programme (CNPq –TWAS) : www.cnpq.br ; www.twas.org
Consortium between Brazilian and Italian Institutions, especialy for Brazil receive
students to do their PhD and then to return home to continue their careers.
Objective: to promote scientific capaccity and excellence for susteinebol development.
Funding – Italian Government; Administration of Finance and Staff – UNESCO
3.
The Latin American Nutrigenomics Organisation - LANUGO
Planning: The Latin American Vitamin Genomics Project (Research Collaborations)
Participation: mínimum 6 countries
To be funded by CYTED - Latinamerican Science & Technology Development
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Programm www.cyted.org
PROGRAMA IBEROAMERICANO DE CIENCIA Y TECNOLOGIA PARA EL DESARROLLO
PROGRAMMA IBERO-AMERICANO DA CIENCIA E TECNOLOGIA PER EL DESENVOLVIMIENTO
LATINAMERICAN SCIENCE & TECHNOLOGY DEVELOPMENT PROGRAMME
11
The Ibero-American Development Program for Science and Technology
(CYTED) was created in 1984 through an International Framework Agreement
signed by 19 Latin American countries, Spain and Portugal.
The CYTED Program is an intergovernmental multilateral Science and Technology
cooperation program, which aims to combine different perspectives and visions to
promote cooperation in Research and Innovation for the development of the Latin
America region.
The principal objective of the CYTED Program is to contribute to harmonious and
sustainable development in the Latin America region through cooperation in science,
technology and innovation.
Another function of the CYTED Program is to enable interregional cooperation in
Science and Technology between the European Union and Latin America.
CYTED is similar to Framework Program of the European Union
12
Currently CYTED is funding the Project
Undernutrition in Iberoamerica (2007-2010)
Objective: to establish an epidemiologic diagnostic of the undernutrition
Coordenation: Spain
Participants: 8 LA countries + Spain and Portugal
Argentina, Chile, Colombia, Brasil, Costa Rica, Cuba,
Equador Espanha, Mexico, Portugal
The Latin American Vitamin Genomics Project: will be planned based on the
results of this epidemiologic diagnostic.
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Vitamin Genomics Project
in Latin America-www.cyted.org
Latinoamerican Nutrigenomics Organisation –
LANUGO
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Figure 3
The Micronutrient Genomics Project Operational Pipeline
Infrastructure component
Micronutrient
Expert Groups
Identify functional
genetic variations
Link to
databases
Identify pathways
& interactions
Create biological
networks
Bioinformatics
Team
Micronutrient
Genomics Portal
Research component
Perform in vitro &
mechanistic studies
Research
Collaborations
Selection of relevant
genetic variations
Perform human
intervention studies
Link to omics
data & results
Link to nutritional
phenotype database
Establish relationships between
genetic variations, micronutrients
and optimal health
15
Latin American contribution to HUMAN VARIOME PROJECT (HVP)
The HVP is an international effort to systematically identify genes, their mutations, and
their variants associated with finotypic variability and indications of human desease.
WORKSHOP: The Human Variome Project (HVP): An international collaboration
to catalogue human genetic variation. Chairs: Richard Cotton and Jim Kaput
INCON (International Conference on Nutrigenomics, next September 26-29, Brazil)
What is the Human Variome Project?
Richard Cotton Coordinator of the HVP, Melbourne, Australia
Genetic Variation and Structure of Brazilian Population related to genetic diseases.
Sérgio Danilo Penna, Federal University of Minas Gerais, MG, Brazil
How can Brazil participate in the Human Variome Project and what is the first step?
Vera Lucia da Silva Lopes, Fac. de Ciências Médicas, Depto. Medical Genetics,
UNICAMP, SP, Brazil
DISCUSSION FORUM
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MICRONUTRIENT GENOMICS PROJECT: Next Meeting
September 26-29, 2010, Guarujá, SP, Brazil.
The International Conference on Nutrigenomics (INCON)
You are well come!!!!!
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Scientific Support
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www.nutrigenomicabrasil.org/congresso/ingles/index.html
Thank you!
Obrigada!
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Rio de Janeiro
2020
Rio de Janeiro21
Pantanal: Vegetal biodiversity22
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Pantanal: Animal biodiversity
Pantanal
24
Copacabana Beach – Rio de Janeiro
25
Amazon Tropical Rain26
Forest
Iguazu Falls
27
São Paulo
28
São Paulo
29
Guarujá
30
Guarujá
31