Beyond Wack-A-Mole Lyme Treatment

Transcription

Beyond Wack-A-Mole
Lyme Treatment
What Has Helped People
to Heal Lyme MCIDs
Concurrent with or Post
Drug Therapy
Integrative Lyme Solutions
Conference
Dallas, Texas
June 21-22, 2013
Two Frogs Healing Center
170 West Patrick Street, Frederick, MD 21701
301.228.3764
www.GoodbyeLyme.com
[email protected]
Greg Lee, M. Ac
Disclosure statement
• No grants
• No industry funding from drug, herb,
medical device suppliers
• Not a paid consultant
• Not on any committees, board of directors,
advisory panels, review boards
• Just me and my two frogs
Background
• Technologist: Software
engineer in NASA Robotics
Lab, Hubble Space
Telescope, spacecraft
integration and testing,
climate modeling projects
• Leadership: Managing partner at
LionHeart Consulting
• Medical: Masters Degree of Acupuncture
and Chinese herbal certification
• Master Sufi Healer
The Question
• Why do some people heal Lyme disease
and their multiple chronic infections and
others do not?
Objectives
• Overview of GoodbyeLyme system
– Treatment challenges in Lyme / Multiple
Chronic Infectious Disease patients
– Natural medicines, strategies, and treatments
for overcoming treatment challenges
• Case studies
• More questions
Patient Challenges
• Patients are highly toxic from antibiotic tx,
environment & childhood exposure to
toxins, lifestyle, dental procedures,
compromised
detox pathways
• Multiple infections
(TBDs, parasites,
secondary infx,
fungi, viral)
Patient Challenges (cont’d)
• Infections hide in reservoirs: biofilms,
cartilage, collagen, skin, nervous
system, inside cells
– Symptoms re-emerge, relapse
• Healing neurological problems,
cognitive difficulties, memory issues
• Immune system over producing
inflammation
• Px resistance to taking bitter tasting herbs,
unusual supplements, receiving treatment
Diagnosis Strategies
• Build patient trust and rapport
• Inquire about patient’s goals, expectations,
sense of urgency, intrinsic motivators
• Needs analysis: Assess underlying
infections, toxicity issues, health of body,
mind, painful emotions, subtle energy,
spirit
Treatment Strategies
• Develop flexible, fluid, customized
treatment plan which includes
recommendations for patient engagement
and compliance
Implementing Treatment
• Acknowledge and address patients chief
concerns & symptoms
• Acknowledge patient’s areas of expertise
• Reduce toxicity
• Kill the pathogenic infection(s)
• Dissolve biofilms
• Target pathogens in reservoirs/hiding areas
• Repair / restore healthy functioning
• Clear bad spirits and invoke Divine healing
Building Patient Trust/Rapport
• Free e-newsletter and free e-report
• GoodbyeLyme.com website articles, blog, video
• 3 hour class for all patients, i.e. am I a good fit?
–
–
–
–
–
–
–
Compassionately acknowledge attendees struggles
Challenges and treatments for Lyme / MCIDs
Treatment approaches
Dietary recommendations
Herb sampling
Clinical results
Address attendee concerns
• Brief one-on-one consult
Diagnosis
• Patient medical history
– Live in or visited tick endemic area
– Symptom progression
– Symptom reaction to foods, medicines, herbs,
allergens, protocols, and treatments
• Labs
– TBDs results
– Biotoxin pathway (Shoemaker)
•
•
•
•
Tongue diagnosis
Pulse changes with herbs, supplements, treatmt
Clinical assessment of suspected infections
Zyto scan with Michael Payne
Diagnosis/Treatment Paradigms
• Chinese medicine Gu Syndrome
– 1900 year old system for treating relapsing
chronic infections
• Three levels of Chinese medicine
– Penetrating Divine Illumination (Tong Shen Ming)
•
•
•
•
Sufi medicine four layers of the heart
Western medical models for infections
Heroes Journey / Monomyth by J. Campbell
Role reversal
Paradigm: Gu Syndrome Properties
• Most doctors appear confused by Gu
pathologies
• Gu pathogens are malicious and life-threatening
• There are thousands of Gu toxins, all of which
cause different symptoms
• Gu toxins are like oil seeping into flour, you
cannot separate them out
• Gu pathogens operate in the dark
• Thriving parasites creating progressive organ
decay along with torturous pain and insanity
• Also translated as “demon syndrome”
Gu Syndrome Herbal Strategy
•
•
•
•
Detoxification
Kill infections and expel demons
Calm the emotions and spirit
Replenish vital energy, blood, and
heal organs and systems
• Move pain, inflammation, and
neurological symptoms out
Paradigm: Chinese 3 Levels of Healing
1. Diagnose and treat symptoms
2. Diagnose and treat underlying
causes
3. Invoke Divine Illumination for intuitive
diagnosis and treatment
– Dust on the mirror, aka Tong Shen Ming
– Doctor as medicine, patient as medicine
• Healing resonates from one level to
other levels
Paradigm: Sufi Healing
• 4 levels of heart are interconnected and holy
• Intervention on one level can
improve healing on other levels
1. Self: Body, mind, desires, “I want”
2. Heart: Emotions, subtle energy field, “I love”
3. Soul: Positive and negative beliefs about self and
illness, “I am”
4. “The One”: Divine Center that is untouched by
illness and capable of complete healing
• Level 4 receiving from Highest Source of
Healing
• Patient can be a mirror for the practitioner
• “Stockdale paradox”
Stockdale Paradox
• “This is what I learned from all those years
in the prison camp:
– You must never ever confuse the need
on one hand for absolute
unwavering faith that you can
prevail despite those constraints
– With the need on the other hand
for the discipline to confront the
brutal facts, whatever they are,
like “We are not going to get out of here
by Christmas.”
Paradigm: Western Medicine
• Physician diagnosed infections and labs
• Evaluate history, symptoms, reaction to
previous treatment for suspected or
hidden infections, dysfunction
• Health of body systems, especially those
impacted by toxins and detoxification
(Shoemaker biotoxins)
• Painful emotions
• Trajectory of healing, level of urgency
Paradigm: Heroes Journey
•
•
•
•
•
•
•
•
•
•
Call to adventure into the unknown
Refusal of the call
Divine aid, mentor
Crossing the first threshold into the
unknown
Belly of the whale, immersed in the unknown
Initiation, trials, tests, perils, illumination
Receiving of Divine gift(s)
Death of the old paradigm, rebirth into the new
Returning to help others with gift(s)
Mastery of both the old and new paradigms
Paradigm: Role Reversal
• If I were in the patient’s shoes, what would I
want from my practitioner?
Natural Medicine Properties
•
•
•
•
•
•
•
Neutralizing, eliminating, or binding toxins
Killing infections
Penetrating biofilms
Strengthen and regulate immune system
Restore healthy functioning
Replenish vital energy
Penetrate into hard-to-access areas of the
body
Natural Medicines
• Bee venom topically, nasal
• Organic and pesticide-free essential oils
• Liposomal supplements and herbs
– Lipo Artemisinin
– Lipo Harmine
– Lipo Glutathione (GSH)
– Lipo Phosphatidyl choline
– Customized Lipo herb formulas
• Herbal tinctures and powders
Medicines: Bee Venom
• Bee venom contains Mellitin which inhibits
Lyme, Babesia, Mycoplasma
• Can produce severe herxheimer reactions
in patients with Lyme, protozoa infections
• Anti-biofilm properties
Medicines: Bee Venom (cont’d)
• Bee venom mixed with sterile saline
– One drop on in eyes, nose, ears can produce
severe herxheimer reactions
– Effective a reversing memory loss, amnesia,
cognitive dysfunction, Bels palsy
– Treats infections in sinuses, brain, eyes, ears
Medicines: Bee Venom (cont’d)
• Topical bee venom mixed with emu oil
– One drop on symptomatic areas, head, joints
can produce severe herxheimer reactions
– Improves cognitive functioning, can bring up
repressed trauma and emotions
– Highly effective against protozoa symptoms
chronic headaches, chest tightness,
shortness of breath
– http://www.ferrisapiaries.com/
Medicines: Essential Oils (EOs)
• Essential oils are highly concentrated
extracts of organic and pesticide-free
fruits, plants, and spices
• EOs have been used safely for decades in
food for flavoring, as antifungal and
antimicrobial agents for food preservation
• Most EOs classified as “generally
recognized as safe” (GRAS) by FDA
• Oral or sublingual dose maximizes
absorption 5-10x over topical application
Medicines: Essential Oils (cont’d)
• Essential oils penetrate and kill germs in
reservoirs: collagen, cartilage, nervous
system, and blood cells
• Essential oils also have phenols which are
solvents which dissolve biofilms
• Low dose essential oils are safe and nontoxic
•
•
•
•
•
•
•
•
•
Basil
•
Bay Laurel •
Bergamont •
Black Cumin* •
Cinnamon* •
Clary sage •
Clove Bud*
Eucalyptus •
Frankincense •
Geranium
Ginger root
Lavender*
Lemon
Lemongrass
Mountain
Savory
Myrrh
Myrtle
•
•
•
•
•
•
•
Nutmeg*
Orange*
Peppermint
Spearmint
Tangerine*
Tea tree
Thyme
*not GRAS
• Basil (broad spectrum anti-bacterial and anti-viral,
calming, treats nausea, vomiting, nervous tension,
mental fatigue, melancholy, migraines and depression)
• Bay Laurel (treats painful conditions like neuralgia,
rheumatism, muscle pain, circulation issues, colds, flu,
and dental infections)
• Bergamont (treats viruses, bacteria, parasites,
protozoa infections like malaria, sadness, depression,
cystitis, urethritis)
• Black cumin (cure for all diseases except for death,
immunomodulatory, stimulates neutrophils, mobilizes
immune system to fight bacterial infections)
• Cinnamon – (anti-bacterial, anti-fungal, penetrates
and kills Lyme under biofilms, purifies and move the
blood, enhances microcirculation in extremities, treats
memory loss, depression, and anxiety)
• Clary sage (anti-convulsive, relieves pain and
spasms, anxiety, depression)
• Clove bud (potent antimicrobial and anti-biofilm, kills
Lyme bacteria even under biofilms, anti-parasitic and
larvicidal, stimulates the mind, removes mental
exhaustion and fatigue, warming and moves stagnant
blood, treats memory loss, depression and anxiety)
• Eucalyptus (Kills staph, cuts biofilms, antiinflammatory, anti-malarial, calms nervous system)
• Frankincense (relieves pain, anti-inflammatory,
enhances immune system, activates circulation)
• Geranium (anti-bacterial, anti-viral, anti-parasitic,
aids elimination of urea, uric acid, bile salts, pathogens,
synthetic chemicals, heavy metals)
• Ginger (treats malaria, yellow fever, bacterial
dysentery, cold and dampness; warms the middle,
warms spleen and stomach coldness, removes phlegm)
• Lemon (anti-bacterial, anti-tuberculosis, treats mental
fatigue, exhaustion, dizziness, anxiety, nervousness,
nervous tension, insomnia)
• Lemongrass (anti-bacterial, anti-fungal, antiprotozoal, anti-malarial, analgesic, reduces tremors)
• Lavender (calms central nervous system, relieves
pain, enhances intestinal mobility, stimulates gastric
juices and bile production, promotes urination)
• Mountain savory (anti-bacteria, anti-viral, antifungal, anti-parasitic, treats intestinal infections, revives
adrenals, immune stimulant, nerve tonic)
• Myrrh (anti-bacterial, anti-fungal, anti-viral, antiinflammatory, disperses blood stagnation, relieves pain)
• Myrtle (clears phlegm, reduces allergic reactions)
• Nutmeg (anti-bacterial, anti-parasitic, larvicidal,
strengthens the heart, detoxifies the liver, treats liver
disease)
• Orange (anti-Lyme, anti-biofilm, moves lymph,
reduces inflammation, promotes exocrine / endocrine
secretions, strengthens people with weak constitutions)
• Peppermint (treats indigestion, respiratory
problems, headache, nausea, fever, stomach and
bowel spasms, anti-parasitic, vents rashes)
• Spearmint (relieves muscle spasms, promotes,
circulation, improves hormone secretion, balances
organs, helps tissue regeneration, anti-syphilitic)
• Tangerine (treats staph, soothes inflammation and
hyperactivity in the respiratory system, circulatory
system, digestive system, nervous system, excretory
system, moves phlegm, improves circulation and
digestion)
• Tea tree (treats persistent infections, bio-films, cystic
forms, anti-bacterial, anti-fungal, anti-parasitic, anti-
protozoal, anti-viral, treats malaria, intestinal infections,
and tropical fevers)
• Thyme (anti-bacterial, anti-parasitic, stimulates white
blood cell production, and strengthens immunity)
Medicines: Liposomal Supplements
• Mix Glutathione (GSH), Vitamin C, and/or
Phosphatidyl Choline with reverse
osmosis water & 5 TBS non-GMO soy or
sunflower lecithin in blender
• Pour mixture in glass canning jar and zap
inside an ultrasonic sterilizer on maximum
sonication for 30 minutes, turn heater off
• Add veggie glycerine, freeze overnight,
then thaw in fridge
Medicines: Liposomal Supplements
(cont’d)
• Patients take 1-4 TBS 1 x day
• Average dose is 1 gm of GSH per day,
clears brain fog
• Phosphatidyl Choline maximum dose 3 gm
a day especially for mold toxicity
• Liposomal anti-toxin supplements will
detoxify herxheimer reaction in minutes
• Reduces toxic symptoms in joints, nervous
system, whole body
Medicines: Liposomal Botanicals
• Anti-microbial medicines wrapped
in liposome / lipids (lecithin)
• Germs eat lipids containing
antimicrobials which kill them
• Liposomal herbs and supplements appear
to penetrate deeper into reservoirs
compared to powdered or tincture herbs
• Use for targeting system wide infection or
germs in hard to reach reservoirs: blood
cells, cartilage, collagen, nervous system
Medicines: Liposomal Botanicals (cont’d)
• Use 12 grams of powdered supplements
and / or herbs for a week’s supply
• Artemisinin, Harmine,
• Anti-bacterial, anti-parasite,
anti-fungal, anti-viral herbs
• Patients report a deeper clearing of their
symptoms compared to tinctures or
powdered herb equivalents
• Great amounts of parasites expelled in stool
Herbal Safety
• Organic, wildcrafted, or lab tested herbs
• Herbs tested 15x or more for active
compounds and contaminants
• Herbs are eliminated that cautioned or
contraindicated with western medicines or
other herbs
Medicines: Herbs for spirochetes
• Anti-spirochete herbs for Lyme disease
and leptospirosis
– Andrographis paniculata (Chinese name: Chuan Xin Lian)
– Radix Polygonum Cuspidati (Chinese name: Hu Zhang)
– Fructus Forsythiae Suspensae (Chinese name: Lian
Qiao)
– Artemisia (Chinese name: Qing Hao)
– Honeysuckle Vine (Chinese name: Ren Dong Teng)
– Smilax (Chinese name: Tu Fu Ling)
– Houttuynia Cordata (Chinese name: Yu Xing Cao)
Medicines: Herbs for Bartonella
• Bartonella symptoms = Chinese medicine
diagnosis of a “fire toxin” illness
• Herbs that eliminate fire toxins reduce
symptoms in Bartonella patients
– Houttuynia Cordata (Chinese name: Yu Xing Cao)
– Dipsacus, Teasel Root, Knotweed (Chinese
name: Xu Duan)
– Artemisia Argyi (Chinese name: Ai Ye)
– Dryopteridis (Chinese name: Guan Zhong)
– Lycopus (Chinese name: Ze Lan)
Herbs for Treating Babesia
• Babesia is a “Half Internal, Half External”
(Shaoyang) Illness similar to malaria
• Anti-malarial herbs and anti-leshmanial
herbs reduce patient’s Babesia symptoms
–
–
–
–
–
–
–
Artemisia Argyi (Chinese name: Ai Ye)
Cardamon (Chinese name: Cao Guo)
Verbena (Chinese name: Ma Bien Cao)
Artemisiae Annuae (Chinese name: Qing Hao)
Agrimonia (Chinese name: Xian He Cao)
Cyanchi (Chinese name: Xu Chang Qing)
Harmine, Syrian Rue extract (Chinese: Luo Tuo Peng Zi)
Herbs for Chronic Infections
• Gu Syndrome herbs for killing parasites
and expelling demons
–
–
–
–
–
–
–
–
Garlic (Chinese name: Da Suan)
Tuber Curcumae (Chinese name: Yu Jin)
Sophorae (Chinese name: Ku Shen)
Cnidium (Chinese name: She Chuang Zi)
Honeysuckle flower (Chinese name: Jin Yin Hua)
Artemisia (Chinese name: Qing Hao)
Acorus (Chinese name: Shi Chang Pu)
Fructus Terminaliae Chebulae (Chinese name: He Zi)
Gu Detoxification herbs
• Gu Syndrome herbs for dispersing toxins
– Folium Perillae Frutescentis (Chinese name: Zi Su
Ye)
– Herba Menthae (Chinese name: Bo He)
– Radix Angelicae Dahurica
(Chinese name: Bai Zhi)
– Fructus Forsythiae Suspensae (Chinese name: Lian
Qiao)
– Rhizoma et Radix Ligustici Sinensis (Chinese name:
Gao Ben)
– Rhizoma Cimicifugae (Chinese name: Sheng Ma)
– Flos Chrysanthemi Morifolii (Chinese name: Ju Hua)
Modern Detoxification herbs
• Anti-endotoxin herbs
– Forsythia (Lian Qiao)*
– Scutellaria Baicalensis
(Huang Qin)
– Honeysuckle Vine
(Ren Dong Teng)
– Patrinia (Bai Jiang Cao)
– Viola (Zi Hua Di Ding)
– Andrographis (Chuan Xin Lian)
– Radix Ligustici Wallichii (Chuan Xiong)*
– Pulsatilla (Bai Tou Weng)
– Sophora (Ku Shen)
* also a Gu Syndrome herb
• Toxin binding herb: Wu Bei Zi (Galla Chinesis)
Detox Treatments
•
•
•
•
•
•
•
•
•
Wet cupping / bloodletting
Scraping
Acupuncture
Moxabustion – burning finely
ground up artemisia on or
near the surface of the skin
Craniosacral technique – hands-on manipulation
for releasing headache pain and joint pain
Cold laser and low light therapy
Frequency Specific Microcurrent
Dietary modifications
Oil pulling
Wet Cupping and Bloodletting
• Wet cupping applies suction cups to
the body for a few minutes.
• The cups are removed and the area
is needled, cups reapplied
• Blood analysis
shows high levels of
toxins, fibrin, cytokines,
hypercoagulation
• Can stop herx
reactions in minutes
Wet Cupping and Bloodletting (cont’d)
Scraping
• Scraping has been practiced for
thousands of years
• AKA “coining”, Gua Sha
• Stainless steel metal instrument is
scraped along patient’s shoulder,
back, legs, arms, hands
• Can quickly reduce or
eliminate stiffness, pain
• Combine with cupping
to facilitate toxin removal
Low Light Therapy
• Low light therapy – uses 670nm near
infrared LED device for healing wounds,
reducing pain, increasing ATP in cells, and
reduces neurotoxicity in rat studies
– LED infrared device is
placed on painful areas
of the body for
approximately 90 seconds
– Patients report decreased
joint pain
– Patients report greater
mental clarity, reduced Bartonella anxiety
when used on the head, combined w/ cupping
Laser Light Therapy (cont’d)
• Intranasal LED “Naser” – uses 808nm
10Hz light for reducing inflammation, nitric
oxide, and increasing ATP in the brain and
target areas
– Naser is placed in the nostril
for 10 – 25 minutes
– Can be used daily at home
– Patients report decreased
pressure, less headaches
– Patients report calmer
emotions, can be combined
with cupping to enhance
detoxification
Acupuncture
• Auricular detoxification acupuncture
– Reduces symptoms of brain
fog and Bels palsy in Lyme
disease patients
– Also used to help drug
addicts to detoxify by Dr.
Michael Smith of Lincoln
Hospital, New York since ‘85
– Used in Florida as an
alternative to incarceration
for drug offenders
• Acupuncture body points enhance toxin
elimination, protect detox organs, builds Qi
Moxabustion
• Finely ground Ultra Pure
Artemisia argyii, Chinese
name Ai Ye is rolled into
½” threads or cones and
placed on symptomatic
areas or acupuncture points
• In patients diagnosed with Bartonella,
moxa has been highly effective at
reducing pain, burning and
toxicity very quickly
• Patients can treat themselves
at home
Dietary Modifications for Detox
• Dietary additions for detox*
– Millet
– Mung beans
– Aduki beans
– Black soybeans
– Swiss chard
– Radishes
– Turnips
– Salt
– Vinegar
– Clay
* Paul Pitchford, Healing With Whole Foods. Berkeley: North Atlantic Books, 2002 , 3rd
Ed.
Dietary Modifications for Detox (cont’d)
• Dietary subtractions*
– Pasteurized cow dairy
– Refined sugars
– Sweet fruits, fructose
– Wheat
– Alcohol
– Artificial sweeteners
• Lifestyle subtractions
– Smoking
– Self neglect
– Mold remediation
Biofilms
• “NIH now says that 80% of infections in
the developed world have biofilms”
- Dr. J. William Costerton, USC Center
for Biofilms at the School of Dentistry
• “when Staphylococcus aureus starts to
form a biofilm, 10 other nearby
[species of] bacteria develop
the ability to attach to the biofilm as well” Dr. Randall Wolcott, Southwest Regional Wound Care
Center in Lubbock, Texas
Biofilms
• Multiple antibiotic resistant Staph have
been found in patient’s nasal passages
two weeks after starting antibiotics – Dr.
Ritchie Shoemaker, Pocomoke, MD
• Drug resistant persister cells have been
found one week after exposure to antibiotics
– Dr. Kim Lewis, Northeastern University
Biofilms (cont’d)
• “We conclude that B. burgdorferi undergoes
genome-wide genetic exchange, including
plasmid transfers.” - Wei-Gang Qiu, et al.
Proceedings of the National Academy of
Sciences
• “We have established conjugal
plasmid transfer
from Escherichia coli to B. [Bartonella]
henselae and used this process to determine
functional origins of replication and antibiotic
resistance genes.” - Christoph Dehio, Pasteur
Institute and Marlene Meyer, Max Planck Institute for
Biology
Biofilms (cont’d)
• “Biofilm bacteria apply chemical weapons in
order to defend themselves against disinfectants and
antibiotics, phagocytes and our immune system.” - Dr.
Carsten Matz, Helmholtz Center for Infection Research
• “We have detailed for the first time the signaling pathway
from nitric oxide to the sensor through cellular
regulators and on to the biological output, biofilm
formation.” - Michael Marletta, PhD., CEO,
Research President at the Scripps Research Institute
Herbal Anti-Biofilm Strategies
• Use herbs (gradually) to penetrate biofilms
– Terminalia Chebula (he zi)
– Berberine extracts from Coptidis Rhizome
(huang lian)
– Cimmcifuga (sheng ma)
– Cinnamon twigs (gui zhi)
– Forsythia (lian qiao)
– Gentiana (long dan cao)
– Granatum rind
Herbal Anti-Biofilm Strategies (cont’d)
• Use herbs to penetrate biofilms (cont’d)
– Honeysuckle flower (jin yin hua)
– Magnolia bark (hu po)
– Mint (bo he)- kills bacteria under oral biofilms
– Mume fruit (wu mei)
– Phellodendron (huang bai)
– Rhubarb (da huang)
– Viola (zi hua di ding)
– Earthworm (di long)
• Terminalia chebula (he zi)
– Binds the intestines
– Treats dysentery
– Stops diarrhea
– Penetrates pseudonomas biofilms and kills
the bacteria
• Add herbs that inhibit or kill drug
resistance MRSA or PRSA
– Scutellaria (Chinese name: Huang Qin)
– Scutellaria Barbarate (Chinese name: Ban Zhi
Lian)
– Acorus (Chinese name: Shi Chang Pu)
– Tonify the Middle and Augment the Qi herbal
formula without ginseng or codonopsis
(Chinese name: bu zhong yi qi tang)
• Add herbs that inhibit nitric oxide
production
– Angelica sinensis, Chinese name: Dang Gui
– Ligusticum or Cnidium root, Chinese name:
Chuan Xiong
– Houttuynia, Chinese name: Yu Xing Cao
– Cyperus Rotundi, Chinese name: Xiang Fu
– Uncaria rhynchophylla, Chinese name: Diao
Gou Teng
– Withania somnifera, Chinese name: Shui Qie,
Ayurvedic name: Ashwagandha
– White Peony Root, Chinese name: Bai Shao
production (cont’d)
– Paederia scandens, Chinese name: Jiangxi
– Schissandra Chinensis, Chinese name: Wu Wei Zi
– Radix Puerariae, Chinese name: Ge Gen
– Ziziphora clinopodioides
– Taraxasterol found in Chinese dandelion,
Chinese name: Pu Gong Ying
– Astragalus Root, Chinese name: Huang Qi
– Helonias Dioica
– Rosa multiflora, Thunb., Chinese name: Ying
Shi
– Polygonum multiflorum, Chinese name: He Shou Wu
– Arisaema cum Bile, Chinese name: Dan Nan Xing
– Angelica sinensis with Sophora flavescens,
Chinese names: Dang Gui and Ku Shen
– Feverfew, Tanacetum parthenium
– Magnolia bark, Chinese name: Hou Po
– Curcumin from Turmeric, Chinese name: Jiang
Huang
– Ericaulon buergerianum, Chinese name: Gu Jing
Cao
– Pulicaria guestii
– Cardamom, Chinese name: Cao Guo
– Harmine from Syrian rue, Chinese name: Luo
Tuo Peng Zi
– Astragalus root with Rehmannia root, Chinese
names: Huang Qi with Sheng Di Huang
– Icariin and ICT from Epimedium, Horny Goat
Weed, Chinese name: Yin Yang Huo
– Hyperoside from Chinese Hawthorn, Chinese
name: Shan Zha
– Black Cumin Seed, Chinese name: Hei Zhong
Cao Zi, Ayurvedic name: Kalonji
Anti-Biofilm Supplements
• Use supplements to penetrate biofilms
– Nattokinase - High amounts of vitamin K2
breaksdown biofilm
– Lumbrokinase
– Rechts Regulat
– Interfase
– Xylitol and lactoferrin
• Use probiotics to decrease pathogens
– Pediococcus probiotics increases healthy
biofilms, can be taken at same time with
antibiotics http://www.imagilin.net/
Dietary Anti-Biofilm Strategies
• Food and herbs to disrupt Quorum
Sensing Communication
– Blueberry
– Raspberry
– Cranberry
– Blackberry
– Grape
– Kale
– Oregano
– Basil
– Rosemary
Dietary Anti-Biofilm Strategies (cont’d)
• Food and herbs to disrupt Quorum
Sensing Communication (cont’d)
– Thyme
– Ginger (Chinese name: sheng jiang)
– Turmeric (Chinese name: jiang huang)
– Raw garlic (Chinese name: da suan)
– Red seaweed / Delisea Pulchra – disrupts
quorum sensing chemical signals
– Scutellaria baicalensis (Chinese name: huang
qin)
Calm the Emotions and Spirit Herbs
• Herbs for calming the emotions and spirit
– Rhizome Polygonati (Huang Jing)
– Lily Bulb (Bai He)
– Glehnia (Bei Sha Shen)
– Scrophularia (Xuan Shen)
– Raw Rehmannia (Sheng Di Huang)
– Quinquefolii (Xi Yang Shen)
– Poria (Fu Shen)
– Rosewood (Jiang Xiang)
– Calcified animal bones (Long Gu)
– Succinum (Hu Po)
– Zizyphus (Suan Zao Ren)
Calm the Emotions and Spirit Herbs
and Treatments
• Herbs for calming the emotions and spirit
(cont’d)
– Polygala (Yuan Zhi)
– Ganoderma, Reishi Mushroom (Ling Zhi)
• Acupuncture
• Craniosacral technique
• Penetrating Divine Illumination (Tong
Shen Ming) Sufi healing
Replenish and Heal Organs & Systems
• Replenish vital energy and heal
organs and systems
– Acupuncture
– Craniosacral, visceral manipulation
– Low Light Therapy
– Liposomal supplements and herbs
– Dietary modifications
Herbs to Replenish & Heal Organs & Systems
• Eucommia Bark (du zhong)
– Strengthens the Kidney, Liver and Heart
functions
– Warming
– Strengthening for the bones and muscles
– Alleviates discomfort in the lower back and
legs
– Calms the nerves while strengthening the
core of the body
Herbs for Regulating Inflammation
• Ganoderma / reishi mushroom (ling zhi)
– Nourishes the heart and calms the spirit
– Strengthens vital energy
– Nourishes the blood
– Hepatoprotective
– Helps to regulate excessive immune system
in auto-immune diseases and allergies
– Ganoderic acids help
• improve liver functions
• fight auto-immune diseases•
• inhibit histamine release
•
• improve oxygen utilization
potent antioxidant freeradical scavengers
supports neurological
healing
• Cordyceps (dong chong xia cao)
– Enhances kidney energy (yang) and
replenishes vital energy (jing / essence)
– Treats kidney weakness / adrenal fatigue
presenting with lumbar and knee soreness,
impotence.
– Significantly blocked the cytokine TNF-alpha
and IL-12 secretion in LPS/IFN-γ stimulated
macrophage cells through reducing inducible
NO synthase expression.
• Ligusticum (Chinese name: chuan xiong)
– Anti-inflammatory and pain reducing effects,
exerting its anti-inflammatory benefits in the
early and the late stages of processes in the
inflammatory pathology
– Contains alkaloids that have been shown in
studies to inhibit TNF-alpha production and
TNF alpha- mediated NF-kappaB activation
• Angelica (Chinese name: dang gui)
– Blood moving herb for decreasing
stagnation (i.e. hypercoagulation)
– Reduces edema in early and late stages
of inflammation by decreasing leukocyte
counts, neutrophil density, and
interleukin-6 (IL-6) expression
– Increases levels of PGD2, an important
natural anti-inflammatory prostaglandin
– A natural source of ferulic acid, a potent
antioxidant that protects cells from
damaging reactive oxygen species
(ROS)
• Scrophularia (Chinese name: xuan shen)
– Reduces brain fog, neck swelling, edema, cell
infiltration and proliferation of activated Tlymphocytes in damaged joint tissues
– Inhibit inflammatory factors, including
prostaglandin E2, leukotriene B4, NO, IL-1B,
IL-2, IL-4, interferon-gamma (INFy) and tumor
necrosis factor-alpha (TNFa)
– no negative effect on the production of
interleukin-10, an anti-inflammatory cytokine
– Contains glycoterpenoid, Verbascosaponin A,
that is twice as potent as the NSAID
indomethacin for relieving inflammation & pain
• Rehmannia (Chinese name: shu di huang)
– Inhibits TNF-1 by inhibiting Interleukin-1 (IL-1)
– Contains a unique iridoid glycoside, catalpol,
that has been shown to exert protective
effects on dopaminergic neurons to help
inhibit microglial activation, thereby reducing
the production of pro-inflammatory factors
Herbs to Regulate the Immune System
• Customized herbal formula for regulating
the immune system
• Based on FAHF-2 developed at Mt. Sinai
Hospital for stopping peanut anaphylaxis
– Oldenlandia (Chinese name: Bai Hua She
She Cao)
– White Peony Root (Chinese name: Bai Shao)
– Salvia (Chinese name: Dan Shen)
– Cordyceps (Chinese name: Dong Chong Xia
Cao)
Herbs to Regulate the Immune System
(cont’d)
– Phellodendron (Chinese name: Huang Bo)
– Scutellaria (Chinese name: Huang Qin)
– Coptidis (Chinese name: Huang Lian)
– Honeysuckle Flower (Chinese name: Jin Yin
Hua)
– Ganoderma (Chinese name: Ling Zhi)
– Cinnamon twig (Chinese name: Gui Zhi)
– Zanthoxylium (Chinese name: Hua Jiao)
– Mume (Chinese name: Wu Mei)
– Rhodiola (Chinese name: Hong Jing Tian)
Inflammatory Cytokines and Herbs
• Analyze the effects of herbs on
inflammatory cytokines and immune
compounds
• Some herbs can increase both proinflammatory and anti-inflammatory
compounds
• Use herbs traditionally used for fighting
infection, reducing toxicity, and draining
inflammation
• Herbs that decrease IL-1 (proinflammatory
cytokine regulators)
– Polygala tenuifolia (Chinese name: yuan zhi)
– Smilax glabra (Chinese name: tu fu ling)
– Uncaria tomentosa (cats claw)
– Rehmannia (Chinese name: sheng di huang)
– Cinnamaldehyde (in cinnamon essential oil)
• Herbs that increase IL-1 (proinflammatory
cytokine regulators)
– Cinnamon bark (Chinese name: rou gui)
– Codonopsis (Chinese name: dang shen)
– Schisandra (Chinese name: wu wei zi)
– Echinacea
– Oldenlandia (Chinese name: bai hua she she
cao)
• Herbs that decrease IL-1a
(proinflammatory cytokine)
– Garlic (Chinese name: da suan)
• Herbs that increase IL-1a
– Acanthopanax Gracilistylus (Chinese name:
wu jia pi)
– Withania somnifera (Ayurvedic name:
Ashwagandha)
– Echinacea
• Herbs that decrease IL-1b (inflammatory
mediator cytokine)
– Chinese nutgalls (Chinese name: wu bei zi)
– Scrophularia (Chinese name: xuan shen)
– Thyme and Oregano essential oil mixture
• Herbs that increase IL-1b
– Echinacea
– Poria (Chinese name: fu ling)
– Milk thistle
• Herbs that decrease IL-2 (T-cell growth)
– Cordyceps (Chinese name: dong chong xia
cao)
– Milk thistle
• Herbs that increase IL-2 (T-cell growth)
– Smilax glabra (Chinese name: tu fu ling)
– Withania somnifera (Ashwagandha)
• Herbs that decrease IL-4 (antiinflammatory cytokine, wound repair)
– Milk thistle
• Herbs that increase IL-4 (anti-inflammatory
cytokine, wound repair)
– Polygala (Chinese name: yuan zhi)
• Herbs that decrease IL-6 (proinflammatory, anti-inflammatory cytokine)
– Astragalus (Chinese name: huang qi)
– Coptis (Chinese name: huang lian)
– Angelica (Chinese name: dang gui)
– Eucalyptus essential oil
– Thyme and oregano essential oil combined
• Herbs that increase IL-6 (proinflammatory, anti-inflammatory cytokine)
– Acanthopanax Gracilistylus (Chinese name:
wu jia pi)
– Aloe vera
– Echinacea
– Milk thistle
– Uncaria tomentosa (cats claw)
• Herbs that decrease IL-8 (proinflammatory cytokine)
– Tree peony (Chinese name: mu dan pi)
• Herbs that increase IL-8
– n/a
• Herbs that decrease IL-10 (antiinflammatory cytokine)
– Echinacea
– Milk thistle
– n/a
• Herbs that do not affect IL-10
• Herbs that decrease IL-12 (stimulates
TNF-a)
cao)
– Ganoderma / Reishi (Chinese name: ling zhi)
• Herbs that decrease TNF (aka TNF-a,
proinflammatory cytokine)
– Acanthopanax Senticosus (Chinese name: ci
wu jia)
– Perilla fruit (Chinese name: su zi)
– Scutellaria (Chinese name: huang qin)
– Smilax (Chinese name: tu fu ling)
– Uncaria tormentosa (cats claw)
– Withania somnifera (Ayurvedic name: Ashwagandha)
• Herbs that decrease TNF (aka TNF-a,
proinflammatory cytokine) (cont’d)
– Ligusticum (Chinese name: chuan xiong)
cao)
– Rehmannia (Chinese name: sheng di huang)
– Eucalyptus essential oil
– Tea tree essential oil
– Cinnamaldehyde in cinnamon essential oil
• Herbs that increase TNF (aka TNF-a,
proinflammatory cytokine)
– Acanthopanax Gracilistylus (Chinese name: xi
zhu wu jia)
– Buplerum (Chinese name: chai hu)
– Cinnamon bark (Chinese name: rou gui)
– Cnidium (Chinese name: she chuang zi)
– Echinacea
– Ginseng (Chinese name: ren shen)
– American ginseng (Chinese name: xi yang
shen)
– Stellaria (Chinese name: yin chai hu)
• Herbs that increase TNF (aka TNF-a,
proinflammatory cytokine) (cont’d)
– Milk thistle
– Terminalia chebula (Chinese name: he zi)
Ashwagandha)
• Herbs that decrease TGF-B (inflammation
and immune response mediator,
overproduction results in increased
inflammation)
– Ass hide glue (Chinese name: e jiao)
• Herbs that increase TGF-B
– n/a
• Herbs that decrease INF-y (activates
macrophages which drives chronic
inflammation)
– Acanthopanax Gracilistylus (Chinese name: xi
zhu wu jia)
– Ginseng (Chinese name: ren shen)
– Corydyceps (Chinese name: dong chong xia cao)
• Herbs that increase INF-y (activates
macrophages which drives chronic
inflammation)
– Corydyceps (Chinese name: dong chong xia
cao)
Ashwagandha)
• Herbs that decrease GM-CSF
• Herbs that increase GM-CSF
– Licorice (Chinese name: gan cao)
– Dioscorea (Chinese name: shan yao)
– Pseudocinnamon
– Codonopsis lanceolata
– Ass hide glue (Chinese name: e jiao)
• Herbs that decrease MMP-9 (delivers
inflammatory elements from the blood into
sensitive tissues, can combine with PAI-1
to increase clot formation and arterial
blockage)
– Polygonum multiflora (Chinese name: he
shou wu, shou wu teng)
– Shark cartilage extract (Neovastat ® (AE941), Squalamine)
• Herbs that decrease MMP-9 (cont’d)
– Soybeans, edamame (Chinese name: mao
dou) (Genistein)
– Aurantii fructus immaturus (Chinese name:
zhi shi) (Nobiletin)
(Curcumin and Xanthorhizzol)
– Green tea (Chinese name: lu cha) (Catechins)
• Herbs that decrease MMP-9 (cont’d)
– Black tea (Chinese name: cha) (Theafllavins)
– Grapes (Resveratrol)
• Herbs that increase MMP-9
– n/a
• Herbs that decrease PAI-1 (inhibits
fibrinolysis)
– Radix Astragali (Chinese name: huang qi)
and Rhizoma Ligustici (Chinese name: chuan
xiong)
and Salvia miltiorrhiza (Chinese name: dan
shen)
• Herbs that increase PAI-1
– n/a
• Herbs that decrease Leptin (cytokines bind
to leptin receptor, blocking MSH
production)
– Pueraria (Chinese name: ge gen) (Puerarin)
• Herbs that increase Leptin
– n/a
Herbs that decrease complement C4a
(biotoxins can chronically elevate C4a)
– n/a
• Herbs that increase complement C4a
– n/a
• Herbs that decrease TGF-Beta1 (antiinflammatory)
and Salvia miltiorrhiza (Chinese name: dan shen)
and Angelica sinensis (Chinese name: dang gui)
– Berberine
– Broccoli (Sulforaphane)
– Rehmannia (Chinese names: shu di huang,
sheng di huang)
• Herbs that increase TGF-Beta1
– n/a
Immune System and Treatment
• Treatments that increase VIP
– Acupuncture
– Homeopathic VIP
Herbs for Moving the “Gu” Out
• Herbs for moving pain, inflammation, and
neurological symptoms out
– Ligusticum (Chinese name: Chuan Xiong)
– Buplerum (Chinese name: Chai Hu)
– Zedoraria (Chinese name: E Zhu)
– Spargani (Chinese name: San Leng)
– Tangerine peel (Chinese name: Chen Pi)
– Auklandia (Chinese name: Mu Xiang)
– Lycopus (Chinese name: Ze Lan)
– Notoginseng (Chinese name: San qi)
Reduce Manganese Strategies
• Lyme bacteria without manganese
transporter BmtA unable to be virulent
• Reduce foods high in manganese
– Teas: Instant, green, black
– Ground cloves
– Saffron
– Cardamom
– Ground ginger
– Toasted wheat germ
– Ground cinnamon
– Rice bran
– Hazelnuts
– Blanched filberts
– Wheat bran
– Dried spearmint
– Dried parsley
– Raw teff
– Dried pine nuts
– Bay leaf
Divine Healing
• Chronic infection of “Gu” is a pathological
darkness that lead to progressive organ
decay, torturous pain, and insanity
– Many patients reported “I’m not my self” or
“Something has taken me over”
• Chinese medicine describes three levels
of healing
– 1st level you treat the symptoms
– 2nd level you treat the person
– 3rd level you invoke Divine insight for intuitive
diagnosis and treatment (not taught today)
Divine Healing (cont’d)
• Sufi healing is a Middle eastern herbal,
dietary, and spiritual healing tradition
– Teach clients a tool called remembrance for
invoking and healing thru their Highest Source
– Some patients need to express symptoms
– Offer depossession treatment as an option to
patients
– Especially effective for reducing persistent
symptoms that do not respond to treatment:
aches or pains, palpitations, unrelenting
headaches, and mood swings
How do I add / integrate alternative treatments?
• Low hanging fruit strategy
– Pick a treatment modality that you matches your
patient’s problem(s) and implement
– Many Lyme LLMP’s start with one supplement or herb
– Medically sound and legally defensible
– Create a mastermind / heart group to support you
• Get trained on herbs, cupping, or detoxification
methods
– Training on October 4th – 6th on the GoodbyeLyme
system
http://goodbyelyme.com/training
• Collaborate with other practitioners
Case Study 1
• 55 yr old caucasian male
– Lives in wooded, endemic area
– 2002 1st symptoms (hands
locked up, flu-like symptoms,
fatigue) treated with steroids, no symptoms
– 2006, his symptoms recurred, treated with
steroids, symptoms resolved
– New symptoms July 2009, positive WB,
treated with doxycycline for four weeks
– Symptoms persisted: Bels palsy, fatigue,
headache, mental fog, pain in right ankle
Case Study 1 (cont’d)
• 55 yr old caucasian male (cont’d)
– Started treatment Sept 2009 with
– Ionic foot detox
– Acupuncture (spleen-4, lung-9, colon-15)
– Sufi depossession treatment
– Three custom herbal formulas (powdered)
• Anti-spirochete
• Detoxification
• Immune enhancer
– 80% of symptoms resolved at the end of the
1st treatment
• 55 yr old caucasian male (cont’d)
– “Felt like a million bucks” two days after
treatment
– Nine weekly treatments of detox foot baths,
acupuncture, wet cupping, Sufi depossession
treatments, burning frankinscense at home,
daily receiving from his Highest Source,
dietary changes, daily herbs
– November 2009 symptom free
– Still symptom free three years later
Case Study 2
• 57 yr old caucasian female
– Lives in tick endemic area, has observed ticks
inside the house
– First symptoms 1998, insect bite, flu and
spotted rash, negative Lyme test, not treated
with antibiotics
– Declining health, bedridden in 2000, reports
head and ears want to explode, recurring rash
on legs, migrating into knees, elbows,
negative Lyme test
– Right knee replacement in 2003
• 57 yr old caucasian female (cont’d)
– Neurological symptoms, brain scans find
nothing wrong in 2004
– Saw multiple specialists, lots of blood tests,
taking pain meds, antidepressants, analgesics
– Stopped all meds in 2009 and felt better
– Started chiropractic, PT, acupuncture
– 2012 acupuncturist refers patient
– Failed VCS test
– + LabCorp WB for Bb, Mycoplasma
pneumonia, HLA-DRDQ multisusceptible,
other co-infection tests negative
– Chief concerns: left shoulder pain 5 of 10,
neck limited ROM 5 of 10, groin & hip pain 5
of 10, feet & ankles always hurt- burn- tinglenumb 5 of 10, right hand weakness and
swelling
– Mar 2012, started bi-weekly treatment
– Ionic foot detox, acupuncture on spleen and
lung meridians, thread moxa on soles of feet
and right hand, cupping and bloodletting on
shoulder, back, right knee.
– Implemented low fat, no dairy, no wheat, low
sugar, organic diet
– Took daily Liposomal Glutathione, anti-Lyme,
anti-Mycoplasma, anti-Bartonella Lipo herbs
– 40%
reduction
of symptoms
at first
treatment
– Symptom free
10 months later
– Lost 33 pounds
– Can walk several
miles
More Questions
• How can we help more patients to get
better more efficiently at a lower cost?
• How can we collaborate more effectively
with each other? Technology? Share what
is working with the sickest patients?
• How can we better measure the
effectiveness of treatment and medicinals
in real-time?
• How will the ACA impact our ability to help
our patients? What do we need to do
about getting ready for ACA?
Conclusion
• Many challenges to healing people with
Lyme disease and multiple infections
• Chinese medicine, alternative medicine
can provide effective tools for overcoming
chronic infections and relapsing symptoms
• Focus on the dust as a way to discover the
perfect mirror within
• www.GoodbyeLyme.com
170 West Patrick Street
Frederick, MD, 21701
301-228-3764
[email protected]
Herb references
•
•
•
•
•
•
Tzeng YM, et al. Evaluation of the anti-inflammatory and anti-proliferation
tumoral cells activities of Antrodia camphotata, Cordyceps sinensis, and
Cinnamomum osmophlpeum bark extracts. Journal of Ethnopharmacology.
(2007)
Liu L, Ning ZQ, Shan S, Zhang K, Deng T, Lu XP, Cheng YY. Phthalide
Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide- induced
TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation.
Planta Med. 2005 Sep;71(9):808-13.
Li YM, Han ZH, Jiang SH, Jiang Y, Yao SD, Zhu DY. Fast repairing of
oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid
glycosides from Scrophularia ningpoensis Hemsl. Acta Pharmacol Sin. 2000
Dec;21(12):1125-8.
Giner RM, Villalba ML, Recio MC, Máñez S, Cerdá-Nicolás M, Ríos J. “Antiinflammatory glycoterpenoids from Scrophularia auriculata,” Eur J
Pharmacol. 2000 Feb 18;389(2- 3):243-52.
Schinella GR, Tournier HA, Prieto JM, Mordujovich de Buschiazzo P, Ríos
JL. Antioxidant activity of anti-inflammatory plant extracts. Life Sci. 2002 Jan
18;70(9): 1023-33.
K. Spellman, et al. Modulation of cytokine expression by traditional
medicines: a review of herbal immunomodulators, Alternative Medicine
Review, June 2006; 11(12): 128-50.
Herb references
•
•
•
•
•
•
•
Liu Jun-song, et al. Inhibitory Effects of Polygoni Multiflori Caulis Extracts on
Matrix Metalloproteinase Activities, Chem. Res. Chinese Universities 2009,
25(2), p. 211—215
Ferdinando Mannello, Natural Bio-Drugs as Matrix Metalloproteinase
Inhibitors: New Perspectives on the Horizon? Recent Patents on AntiCancer Drug Discovery, 2006, 1, p. 91-103
Lu ZM, et al. The protective effects of Radix Astragali and Rhizoma Ligustici
chuanxiong on endothelial dysfunction in type 2 diabetic patients with
microalbuminuria. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul;36(4),
p.529-32
Yang Y, et al. Compound Astragalus and Salvia miltiorrhiza Extract exerts
anti-fibrosis by mediating TGF-beta/Smad signaling in myofibroblasts. J
Ethnopharmacol. 2008 Jul 23;118(2), p. 264-70
Wang H, et al. Antifibrotic effect of the Chinese herbs, Astragalus
mongholicus and Angelica sinensis, in a rat model of chronic puromycin
aminonucleoside nephrosis. Life Sci. 2004 Feb 13;74(13), p. 1645-58.
Liu Y, et al. Protective effects of berberine on radiation induced lung injury
via intercellular adhesion molecular-1 and transforming growth factor-beta-1
in patients with lung cancer. Eur J Cancer. 2008;44(16):2425-2432.
Traka M, et al. Broccoli consumption interacts with GSTM1 to perturb
oncogenic signalling pathways in the prostate. PLoS One. 2008;3(7):e2568.
Herb references
•
•
•
•
Zheng Y. The therapeutic effects of rehmannia oral liquid for the syndrome
of heat accumulation with Yin consumption in esophagus cancer patients
undergoing radiotherapy—a report of 60 cases. J Tradit Chin Med.
2007;27(4):248-254.
Yu HM, et al. Effects of rhubarb extract on radiation induced lung toxicity via
decreasing transforming growth factor-beta-1 and interleukin-6 in lung
cancer patients treated with radiotherapy. Lung Cancer. 2008;59(2):219226.
Ji WJ, et al. Attenuation of silica-induced pulmonary fibroblasts proliferation
by taurine and niacin in vitro. Exp Lung Res. 2009;35(3):198-209.
Kawakami F, et al. Characterization of complement C3 as a glycyrrhizin
(GL)-binding protein and the phosphorylation of C3alpha by CK-2, which is
potently inhibited by GL and glycyrrhetinic acid in vitro. J Biochem. 2003
Feb;133(2), p. 231-7
Detoxification herbs references
• Gu Syndrome herbs
– Heiner Fruehauf, Gu Syndrome: A Forgotten Clinical Approach
to Chronic Parasitism, J. Chinese Medicine, 1997, 57, p10-17
• Anti-endotoxin herbs
– Zhang Xia, Cui Naije and Wang Jiatai, The antagonistic action of
heat-clearing and detoxifying Chinese drugs on endotoxins, J
TCM 2001; 21(1): p72-77
– Yang Mingwei;Li Mingzhen;Ye Wangyun et al, Comparative
Study of Effects of the Mixture Reduqing and Its Four
Component Herbs──Influence on Endotoxin in vivo and in vitro,
Institute of Integrated Traditional Chinese and Western
Medicine,Tongji Medical University, Wuhan 1996
– Lonicera and Forsythia: Representatives of the "Floating" ToxinCleaning Herbs: http://www.itmonline.org/arts/lonicera.htm 2002
Detox acupucture references
– Brewington V, Smith M, Lipton D., Acupuncture as a
detoxification treatment: an analysis of controlled
research. J Subst Abuse Treat. 1994 Jul-Aug;11(4), p289-307
– Sheng Li Ke Xue Jin Zhan, Acupuncture for the treatment of drug
addiction. Neuroscience Research Institute, Peking University,
Beijing, China. 2008 Oct;39(4), p325-30
References for anti-spirochete herbs
• Subhuti Dharmananda, Lyme disease:
Treatment with Chinese Herbs,
http://www.itmonline.org/arts/lyme.htm
• Qincai Zhang and Y Zhang. Lyme Disease and
Modern Chinese Medicine. New York, Sino-Med
Research Institute. 2006
References for anti-Bartonella herbs
• Chen, John K., and Tina T. Chen. 2004. Chinese
Medical Herbology and Pharmacology. City of
Industry CA: Art of Medicine Press, Inc.
Research Institute. 2006, p.34
References for anti-Babesia herbs
• Chen, John K., and Tina T. Chen. 2004. Chinese
Medical Herbology and Pharmacology. City of
Industry CA: Art of Medicine Press, Inc.
Research Institute. 2006, p.42
• Lala, Sanchaita; et al. Harmine: Evaluation of its
Antileishmanial Properties in Various Vesicular
Delivery Systems. Journal of Drug Targeting.
Vol. 12. No. 3., pp. 165 – 175.
References for anti-Biofilm herbs
1. USC Establishes Center for Biofilms,
http://www.usc.edu/uscnews/stories/10661.html. November 18, 2004.
2. Interview with Dr. Bonnie Bassler, NOVA scienceNOW,
http://www.pbs.org/wgbh/nova/sciencenow/3401/04-bact.html. October
19, 2006.
3. Plate L, Marletta MA. Nitric oxide modulates bacterial biofilm
formation through a multicomponent cyclic-di-GMP signaling network.
Mol Cell. 2012 May 25;46(4):449-60. doi:
10.1016/j.molcel.2012.03.023.
http://www.ncbi.nlm.nih.gov/pubmed/22542454
4. Angela R. Kamera, R. G. Craigab, A. P. Dasanayakec, M. Brysd, L.
Glodzik-Sobanskad, M. J. de Leon. Inflammation and Alzheimer's
disease: Possible role of periodontal diseases. Alzheimer's and
Dementia, The Journal of the Alzheimer's Association, Volume 4, Issue
4, July 2008. Pubmed
5. Bien-Aim H. Lubraine, Kaur N., Datar A., Luecke D., Mpoy C.,
Pabbati N., Sapi Eva. Expression Profile of Quorum Sensing
Biomarkers during Biofilm Development in Borrelia burgdorferi. ILADS
Conference presentation, October 25, 2009. ILADS
6. Interview with Dr. Randall Wolcott,
http://bacteriality.com/2008/04/13/wolcott/. April 13, 2008.
7. Ritchie Shoemaker, P. Schmidt. Mold Warriors. Gateway Press,
Baltimore, Maryland. 2005. P. 101. Amazon
8. Different Multidrug Resistance Transporters,
http://commons.wikimedia.org/wiki/File:Different_Multidrug_Resistance
_Transporters.jpg. January 5, 2008.
9. Wei-Gang Qiu, S. E. Schutzer, J. F. Bruno, O. Attie, Y. Xu, J. J.
Dunn, C. M. Fraser, S. R. Casjens, and B. J. Luft. Genetic exchange
and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by
three-way genome comparisons and multilocus sequence typing.
Proceedings of the National Academy of Sciences, Vol. 101 No. 39,
10. Christoph Dehio and Marlene Meyer. Maintenance of Broad-HostRange Incompatibility Group P and Group Q Plasmids and
Transposition of Tn5 in Bartonella henselae following Conjugal Plasmid
Transfer from Escherichia coli. Journal of Bacteriology, January 1997,
p. 538–540. Journal of Bacteriology
11. Gary P Wormser, A. Prasad, E. Neuhaus, S. Joshi, J.
Nowakowski, J. Nelson, A. Mittleman, M. Aguero-Rosenfeld, J.
Topal, P. Krause. Emergence of resistance to azithromycinatovaquone in immunocompromised patients with Babesia microti
infection. Clinical Infectious Diseases. February 1, 2010. Pubmed
12. Ran Nir-Paz, M-C. Prévost, P. Nicolas, A. Blanchard, and H.
Wróblewski. Susceptibilities of Mycoplasma fermentans and
Mycoplasma hyorhinis to Membrane-Active Peptides and Enrofloxacin
in Human Tissue Cell Cultures. Antimicrobial Agents Chemotherapy.
May 2002. Antimicrobial Agents and Chemotherapy
13. Biofilm. Wikipedia. http://en.wikipedia.org/wiki/Biofilm
14. R.W.K. Wong, U. Hägg, L. Samaranayake, M.K.Z. Yuen, C.J.
Seneviratne, R. Kao. Antimicrobial activity of Chinese medicine herbs
against common bacteria in oral biofilm. A pilot study. International
Journal of Oral and Maxillofacial Surgery Online, April 26, 2010.
15. Wang X, Yao X, Zhu Z, Tang T, Dai K, Sadovskaya I, Flahaut S,
Jabbouri S. Effect of berberine on Staphylococcus epidermidis biofilm
formation. International Journal of Antimicrobial Agents. July 2009.
16. Private email with Dr. Heiner Fruehauf, Founding Professor, School
of Classical Chinese Medicine. January 28, 2009.
17. Madhavi Gavini, ISEF 2006 Intel Foundation Young Scientist,
http://www.cogito.org/articles/
articledetail.aspx?ContentID=15951, December 12, 2006.
18. Phone conversation with Dr. Norton Fishman. June 19, 2009.
19. Klinghardt, Dietrich. A Treatment Guide: Chronic Infections. Lyme
disease Protocol October 2009 Powerpoint Presentation.
http://www.klinghardt.org/ning/LymeProtocolOct09.pdf
20. Private email with Dr. Heiner Fruehauf, Founding Professor, School
of Classical Chinese Medicine. June 19, 2009.
21. Ammons MC, Ward LS, Fisher ST, Wolcott RD, James GA. In vitro
susceptibility of established biofilms composed of a clinical wound
isolate of Pseudomonas aeruginosa treated with lactoferrin and xylitol.
International Journal of Antimicrobial Agents. 2009. Pubmed
22. D.A. Vattem, K. Mihalika, S.H. Crixella and R.J.C. McLean. Dietary
phytochemicals as quorum sensing inhibitors. Fitoterapia, Volume 78,
Issue 4, June 2007. Pubmed
23. Rasmussen, T. B., Bjarnsholt, T., Skindersoe, M. E., Hentzer, M.,
Kristoffersen, P., Kote, M., Nielsen, J., Eberl, L. & Givskov, M. (2005).
Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic
system, the QSI Selector. Journal of Bacteriology 187, 1799-1814
24. Rasmussen, T. B., Manefield, M., Andersen, J. B., Eberl, L.,
Anthoni, U., Christophersen, C., Steinberg, P., Kjelleberg, S. &
Givskov, M. (2000). How Delisea pulchra furanones affect quorum
sensing and swarming motility in Serratia liquefaciens MG1.
Microbiology 146, 3237-3244.
25. Zeng, Zhirui, Qian, L., .,Cao, L., Tan, H., Huang, Y., Xue, X., Shen,
Y., Zhou, S. Virtual screening for novel quorum sensing inhibitors to
eradicate biofilm formation of Pseudomonas aeruginosa. Applied
Microbiology and Biotechnology, Volume 79, Number 1, May 2008 , pp.
119-126. Pubmed
26. Buhner, Stephen. Herbal Antibiotics: Natural Alternatives for
Treating Drug-Resistant Bacteria. Storey Publishing, North Adams,
Massachusetts. 1999 Amazon
27. Bensky D and Gamble A. Chinese Herbal Medicine Materia
Medica. Revised edition. Seattle, WA. Eastland Press. 1993. Amazon
28. Kathy Abascal, Eric Yarnell. Herbs and Drug Resistance: Part 2—
Clinical Implications of Research on Microbial Resistance to Antibiotics.
Alternative and Complementary Therapies. October 2002. Liebert
29. Chen, Li, X. Cheng, W. Shi. Inhibition of Growth of Streptococcus
mutans, Methicillin-Resistant Staphylococcus aureus, and VancomycinResistant Enterococci by Kurarinone, a Bioactive Flavonoid Isolated
from Sophora flavescens. Journal of Clinical Microbiology, July 2005
30. Scott Treadway, Exploring the Universe of Ayurvedic Botanicals to
Manage Bacterial Infections. Clinical Nutrition Insights, Advanced
Nutrition Publications, Inc. 1998.
31. Plate L, Marletta MA.
32. Koh PO. Ferulic acid modulates nitric oxide synthase expression in
focal cerebral ischemia. Lab Anim Res. 2012 Dec;28(4):273-8. doi:
10.5625/lar.2012.28.4.273. Pubmed
33. Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CW, Chen JP, Dong
TT, Choi RC, Lau DT, Tsim KW. Chemical and biological assessment
of angelica roots from different cultivated regions in a chinese herbal
decoction danggui buxue tang. Evid Based Complement Alternat Med.
2013;2013:483286. doi: 10.1155/2013/483286. Pubmed
34. Li W, Guo J, Tang Y, Wang H, Huang M, Qian D, Duan JA.
Pharmacokinetic Comparison of Ferulic Acid in Normal and Blood
Deficiency Rats after Oral Administration of Angelica sinensis,
Ligusticum chuanxiong and Their Combination. Int J Mol Sci.
2012;13(3):3583-97. doi: 10.3390/ijms13033583. Pubmed
35. Li W, Fan T, Zhang Y, Fan T, Zhou P, Niu X, He L. Houttuynia
cordata Thunb. Volatile Oil Exhibited Anti-inflammatory Effects In Vivo
and Inhibited Nitric Oxide and Tumor Necrosis Factor-a Production in
LPS-stimulated Mouse Peritoneal Macrophages In Vitro. Phytother
Res. 2012 Dec 20. doi: 10.1002/ptr.4905. Pubmed
36. Hemanth Kumar K, Tamatam A, Pal A, Khanum F. Neuroprotective
effects of Cyperus rotundus on SIN-1 induced nitric oxide generation
and protein nitration: ameliorative effect against apoptosis mediated
neuronal cell damage. Neurotoxicology. 2013 Jan;34:150-9. doi:
10.1016/j.neuro.2012.11.002. Pubmed
37. Jung HY, Nam KN, Woo BC, Kim KP, Kim SO, Lee EH. Hirsutine,
an indole alkaloid of Uncaria rhynchophylla, inhibits inflammationmediated neurotoxicity and microglial activation. Mol Med Rep. 2012
Oct 19. doi: 10.3892/mmr.2012.1135. Pubmed
38. Manjunath MJ, Muralidhara. Effect of Withania somnifera
Supplementation on Rotenone-Induced Oxidative Damage in
Cerebellum and Striatum of the Male Mice Brain. Cent Nerv Syst
Agents Med Chem. 2013 Mar 1;13(1):43-56. Pubmed
39. Zhang W, Dai SM. Mechanisms involved in the therapeutic effects
of Paeonia lactiflora Pallas in rheumatoid arthritis. Int
Immunopharmacol. 2012 Sep;14(1):27-31. doi:
10.1016/j.intimp.2012.06.001. Pubmed
40. Liu M, Zhou L, Chen Z, Hu C. Analgesic effect of iridoid glycosides
from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on spared
nerve injury rat model of neuropathic pain. Pharmacol Biochem Behav.
2012 Sep;102(3):465-70. doi: 10.1016/j.pbb.2012.06.007. Pubmed
41. Bae H, Kim R, Kim Y, Lee E, Jin Kim H, Pyo Jang Y, Jung SK, Kim
J. Effects of Schisandra chinensis Baillon (Schizandraceae) on
lipopolysaccharide induced lung inflammation in mice. J
Ethnopharmacol. 2012 Jun 26;142(1):41-7. doi:
10.1016/j.jep.2012.04.009. Pubmed
42. Yao XJ, Yin JA, Xia YF, Wei ZF, Luo YB, Liu M, Feleder C, Dai Y.
Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in
rats involving inhibition of pyrogen production from macrophages. J
Ethnopharmacol. 2012 May 7;141(1):322-30. doi:
10.1016/j.jep.2012.02.038. Pubmed
43. Furukawa M, Oikawa N, Imohata T, Makino M, Ogawa S, Iida T,
Fujimoto Y, Kitanaka S. Monoterpene glucosides from Ziziphora
clinopodioides (Labiatae). Chem Pharm Bull (Tokyo). 2012;60(3):397401. Pubmed
44. Zhang X, Xiong H, Liu L. Effects of taraxasterol on inflammatory
responses in lipopolysaccharide-induced RAW 264.7 macrophages. J
Ethnopharmacol. 2012 May 7;141(1):206-11. doi:
10.1016/j.jep.2012.02.020. Pubmed
45. Lau KM, Lai KK, Liu CL, Tam JC, To MH, Kwok HF, Lau CP, Ko
CH, Leung PC, Fung KP, Poon SK, Lau CB. Synergistic interaction
between Astragali Radix and Rehmanniae Radix in a Chinese herbal
formula to promote diabetic wound healing. J Ethnopharmacol. 2012
May 7;141(1):250-6. doi: 10.1016/j.jep.2012.02.025. Pubmed
46. Chakraborty D, Samadder A, Dutta S, Khuda-Bukhsh AR.
Antihyperglycemic potentials of a threatened plant, Helonias dioica:
antioxidative stress responses and the signaling cascade. Exp Biol Med
(Maywood). 2012 Jan 1;237(1):64-76. doi: 10.1258/ebm.2011.011161.
Pubmed
47. Guo D, Xu L, Cao X, Guo Y, Ye Y, Chan CO, Mok DK, Yu Z, Chen
S. Anti-inflammatory activities and mechanisms of action of the
petroleum ether fraction of Rosa multiflora Thunb. hips. J
Ethnopharmacol. 2011 Dec 8;138(3):717-22. doi:
10.1016/j.jep.2011.10.010. Pubmed
48. Tao L, Li X, Zhang L, Tian J, Li X, Sun X, Li X, Jiang L, Zhang X,
Chen J. Protective effect of tetrahydroxystilbene glucoside on 6-OHDAinduced apoptosis in PC12 cells through the ROS-NO pathway. PLoS
One. 2011;6(10):e26055. doi: 10.1371/journal.pone.0026055. Pubmed
49. Ahn CB, Je JY. Anti-inflammatory activity of the oriental herb
medicine, Arisaema cum Bile, in LPS-induced PMA-differentiated THP1 cells. Immunopharmacol Immunotoxicol. 2012 Jun;34(3):379-84. doi:
10.3109/08923973.2011.608683. Pubmed
50. Han C, Guo J. Antibacterial and anti-inflammatory activity of
traditional Chinese herb pairs, Angelica sinensis and Sophora
flavescens. Inflammation. 2012 Jun;35(3):913-9. doi: 10.1007/s10753011-9393-6. Pubmed
51. Aviram A, Tsoukias NM, Melnick SJ, Resek AP, Ramachandran C.
Inhibition of nitric oxide synthesis in mouse macrophage cells by
feverfew supercritical extract. Phytother Res. 2012 Apr;26(4):541-5.
doi: 10.1002/ptr.3594. Pubmed
52. Lee M, Kwon BM, Suk K, McGeer E, McGeer PL. Effects of
obovatol on GSH depleted glia-mediated neurotoxicity and oxidative
damage. J Neuroimmune Pharmacol. 2012 Mar;7(1):173-86. doi:
10.1007/s11481-011-9300-9. Pubmed
53. Mito S, Thandavarayan RA, Ma M, Lakshmanan A, Suzuki K,
Kodama M, Watanabe K. Inhibition of cardiac oxidative and
endoplasmic reticulum stress-mediated apoptosis by curcumin
treatment contributes to protection against acute myocarditis. Free
Radic Res. 2011 Oct;45(10):1223-31. doi:
10.3109/10715762.2011.607252. Pubmed
54. Wang M, Zhang Z, Cheang LC, Lin Z, Lee SM. Eriocaulon
buergerianum extract protects PC12 cells and neurons in zebrafish
against 6-hydroxydopamine-induced damage. Chin Med. 2011 Apr
28;6:16. doi: 10.1186/1749-8546-6-16. Pubmed
55. Alghaithy AA, El-Beshbishy HA, Abdel-Naim AB, Nagy AA, AbdelSattar EM. Anti-inflammatory effects of the chloroform extract of
Pulicaria guestii ameliorated the neutrophil infiltration and nitric oxide
generation in rats. Toxicol Ind Health. 2011 Nov;27(10):899-910. doi:
10.1177/0748233711399320. Pubmed
56. Wang JH, Shin JW, Choi MK, Kim HG, Son CG. An herbal fruit,
Amomum xanthoides, ameliorates thioacetamide-induced hepatic
fibrosis in rat via antioxidative system. J Ethnopharmacol. 2011 May
17;135(2):344-50. doi: 10.1016/j.jep.2011.03.026. Pubmed
57. Yamazaki Y, Kawano Y. Inhibitory effects of herbal alkaloids on the
tumor necrosis factor-a and nitric oxide production in
lipopolysaccharide-stimulated RAW264 macrophages. Chem Pharm
Bull (Tokyo). 2011;59(3):388-91. Pubmed
58. Tam JC, Lau KM, Liu CL, To MH, Kwok HF, Lai KK, Lau CP, Ko
CH, Leung PC, Fung KP, Lau CB. The in vivo and in vitro diabetic
wound healing effects of a 2-herb formula and its mechanisms of
action. J Ethnopharmacol. 2011 Apr 12;134(3):831-8. doi:
10.1016/j.jep.2011.01.032. Pubmed
59. Zhou J, Wu J, Chen X, Fortenbery N, Eksioglu E, Kodumudi KN, Pk
EB, Dong J, Djeu JY, Wei S. Icariin and its derivative, ICT, exert antiinflammatory, anti-tumor effects, and modulate myeloid derived
suppressive cells (MDSCs) functions. Int Immunopharmacol. 2011
Jul;11(7):890-8. doi: 10.1016/j.intimp.2011.01.007. Pubmed
60. Kim SJ, Um JY, Lee JY. Anti-inflammatory activity of hyperoside
through the suppression of nuclear factor-?B activation in mouse
peritoneal macrophages. Am J Chin Med. 2011;39(1):171-81. Pubmed
61. Zhang D, Nie X, Pan H, Yu L, Yang X, Xu J, Bian K. Study on effect
of total saponins from Semen Nigellae on inflammatory mediators and
ERK/MAPK pathway in stimulated macrophage. Zhongguo Zhong Yao
Za Zhi. 2010 Oct;35(19):2594-8. Pubmed
62.Priyanka HP, Bala P, Ankisettipalle S, ThyagaRajan S. Bacopa
monnieri and L-deprenyl differentially enhance the activities of
antioxidant enzymes and the expression of tyrosine hydroxylase and
nerve growth factor via ERK 1/2 and NF-?B pathways in the spleen of
female wistar rats. Neurochem Res. 2013 Jan;38(1):141-52. doi:
10.1007/s11064-012-0902-2. Pubmed
63.Lau YS, Kwan CY, Ku TC, Hsieh WT, Wang HD, Nishibe S,
Dharmani M, Mustafa MR. Apocynum venetum leaf extract, an
antihypertensive herb, inhibits rat aortic contraction induced by
angiotensin II: a nitric oxide and superoxide connection. J
Ethnopharmacol. 2012 Sep 28;143(2):565-71. doi:
10.1016/j.jep.2012.07.012. Pubmed
64. Muñoz M, Bermejo-Bescós P, Romero C, Benedí J, Martín-Aragón
S. SNP-mediated neuroprotection under glucose deprivation is
enhanced by Hypericum perforatum. CNS Neurol Disord Drug Targets.
2012 Mar;11(2):162-73. Pubmed
65. Zhu CP, Zhang SH. Lycium barbarum polysaccharide inhibits the
proliferation of HeLa cells by inducing apoptosis. J Sci Food Agric.
2012 Jun 13. doi: 10.1002/jsfa.5743. Pubmed
66. Pan C, Huo Y, An X, Singh G, Chen M, Yang Z, Pu J, Li J. Panax
notoginseng and its components decreased hypertension via
stimulation of endothelial-dependent vessel dilatation. Vascul
Pharmacol. 2012 Mar-Apr;56(3-4):150-8. doi:
10.1016/j.vph.2011.12.006. Pubmed
67. Choi DH, Lee YJ, Kim JS, Kang DG, Lee HS.Cynanchum wilfordii
ameliorates hypertension and endothelial dysfunction in rats fed with
high fat/cholesterol diets. Immunopharmacol Immunotoxicol. 2012
Feb;34(1):4-11. doi: 10.3109/08923973.2011.569889. Pubmed
68. Aranha I, Clement F, Venkatesh YP. Immunostimulatory properties
of the major protein from the stem of the Ayurvedic medicinal herb,
guduchi (Tinospora cordifolia). J Ethnopharmacol. 2012 Jan
31;139(2):366-72. doi: 10.1016/j.jep.2011.11.013. Pubmed
69. Lee JO, Oak MH, Jung SH, Park DH, Auger C, Kim KR, Lee SW,
Schini-Kerth VB. An ethanolic extract of Lindera obtusiloba stems
causes NO-mediated endothelium-dependent relaxations in rat aortic
rings and prevents angiotensin II-induced hypertension and endothelial
dysfunction in rats. Naunyn Schmiedebergs Arch Pharmacol. 2011
Jun;383(6):635-45. doi: 10.1007/s00210-011-0643-9. Pubmed
70. Chan P, Liu JC, Lin LJ, Chen PY, Cheng TH, Lin JG, Hong HJ.
Tanshinone IIA inhibits angiotensin II-induced cell proliferation in rat
cardiac fibroblasts. Am J Chin Med. 2011;39(2):381-94. Pubmed
Cupping references
• Michalsen A, et al, Effects of traditional cupping therapy
in patients with carpal tunnel syndrome: a randomized
controlled trial. J Pain. 2009 Jun;10(6), p601-8 -> Carpal
tunnel pain was reduced over 50% at seven day follow
up after only one treatment.
• Farhadi K, et al, The effectiveness of wet-cupping for
nonspecific low back pain in Iran: a randomized
controlled trial. Complement Ther Med. 2009 Jan;17(1),
p9-15 -> Low back pain significantly reduced at three
month follow up.
• Ahmadi A, et al, The efficacy of wet-cupping in the
treatment of tension and migraine headache. Am J Chin
Med. 2008;36(1), p37-44 -> Headache serverity
decreased 66%.
Low Light Therapy References
• Nicole L. Lohr, et al. Enhancement of nitric oxide release
from nitrosyl hemoglobin and nitrosyl myoglobin by
red/near infrared radiation: Potential role in
cardioprotection. J Molecular and Cellular Cardiology
2009 Mar; 47 p.256-263
• Rong Ying, et al. Pretreatment with near-infrared light via
light-emitting diode provides added benefit against
rotenone- and MPP+-induced neurotoxicity. J Brain
Research 2008 Sep; 1243 p. 167-173.
• J. Eells et al. Mitochondrial signal transduction in
accelerated wound and retinal healing by near-infrared
light therapy. Mitochondrion 2004 Jul; 4 p.559–567

Beyond Wack-A-Mole Lyme Treatment

Transcription

Similar documents

Case study: 3rd -5th grade

DOMAINfest 2015 - 2015-09-17 Xinhua

Al-Khemia21-120x75 TWO_ENG.ai

hafeilobopartsmanual

Gparty - Faranda`s Farm

NORCAL CHINESE CHURCH CONFERENCE

newsletter april 2004 - New Zealand China Friendship Society Inc

Good Fortune Boxes - Dick Blick Art Materials

Twentieth Century Settlers in the Blackstone Valley

20100420 zhoubao New