Wednesday 4 March 2015 - Edinburgh

Transcription

W ednesday 4
th
M arch 2015
Royal College of Physicians of Edinburgh
Queen Street
#EdinNeuroDay
Neuroscience Day 2015 Supporters
Edinburgh Neuroscience would like to thank all the centres and organisations
that have contributed to Neuroscience Day 201 5:
University of Edinburgh: Anne Rowling Regenerative Neurology Clinic, Biomedical
Teaching Organisation, Centre for Clinical Brain Sciences, Centre for Cognitive Ageing
& Cognitive Epidemiology, Centre for Cognitive & Neural Systems, Centre for
Integrative Physiology, Centre for Neuroregeneration, Centre for Regenerative
Medicine, CMVM Initiative in Skills Training Fund, Neuroimaging Sciences, MS Centre,
Neuroinformatics Doctoral Training Centre, Patrick Wild Centre for Research into
Autism, Fragile X Syndrome & Intellectual Disabilities, Psychology, The Roslin Institute
Organisations and Companies: Takeda Cambridge UK (poster competition prizes),
Guarantors of Brain, Proteintech, Scottish Mental Health Research Network
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Neuroscience Day 2015
Programme of Talks
08.30
Arrival and Registration
Session 1
Chaired by: Prof Charles ffrench-Constant, Director, Edinburgh Neuroscience
09.00
Welcome
Prof Charles ffrench-Constant, Director, Edinburgh Neuroscience and MRC Centre for Regenerative
Medicine
09.15
The role of general attention in working memory: cognitive and neuroimaging
evidence
Prof Nelson Cowan, Psychology and University of Missouri-Columbia, USA
09.40
Lumping and splitting: how hippocampal place cells support and constrain spatial
cognition
Dr Emma Wood, Centre for Cognitive & Neural Systems
10.05
Signalling pathways to degeneration or resilience
Prof Giles Hardingham, Centre for Integrative Physiology
10.30
Coffee & Posters
Session 2
Chaired by: Prof David Wyllie, Centre for Integrative Physiology
11.10
End-Stage Brain Failure: Prevention will be better (and easier to achieve) than cure
Prof Craig Ritchie, Psychiatry, Centre for Clinical Brain Sciences
11.35
Fellows Session 1
Neuroanatomical changes and cognitive decline during the eighth decade of life
Dr Stuart Ritchie, Centre for Cognitive Ageing & Cognitive Epidemiology
GABA-independent GABA-receptors: new factor in inhibitory signalling
Dr Sergiy Sylantyev, Centre for Clinical Brain Sciences
Defining pathways which drive neuroinflammation
Dr David Hunt, Euan MacDonald Centre for MND Research and Institute for Genetics & Molecular
Medicine
12.15
Ages of the Brain - a week in the life of Edinburgh Neuroscience, captured by its
members
Dr Robin Morton,, Centre for Cognitive Ageing & Cognitive Epidemiology
12.20
Lunch & Posters
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Session 3
Chaired by:
13.50
Prof Catherina Becker, Centre for Neuroregeneration
Chancellor’s Fellows Session 2
Novel approaches to understanding the genomics of psychiatric disorders
Dr Kristin Nicodemus, Centre for Genomics & Experimental Medicine
Translational control of gene expression in neuropsychiatric diseases
Dr Christos Gkogkas, Centre for Integrative Physiology and Patrick Wild Centre
Understanding and improving treatment decision-making capacity in psychosis
Dr Paul Hutton, Clinical Psychology
14.30
What does greenspace do to your headspace?
Prof Catharine Ward Thompson, Architecture & Landscape Architecture, Edinburgh College of Art
14.55
Growth, inflammation and the brain
Prof Andrew Jackson, MRC Human Genetics Unit, Institute for Genetics & Molecular Medicine
15.20
Tea and Posters
Session 4
15.55
Announcement of the Takeda Poster Competition winners
Presentation by Dr Pascal Goetghebeur, Takeda Cambridge Ltd
16.00
Annual Distinguished Lecture in Neuroscience 2013
On the level: Equilibrium in the brain
Professor Huda Zoghbi, Department of Molecular and Human Genetics, Departments of
Paediatrics, Neurology and Developmental Neuroscience, Howard Hughes Medical Institute, Baylor
College of Medicine Introduced by Prof Peter Kind, Patrick Wild Centre for Research into
Autism, Fragile X Syndrome & Intellectual Disabilities
17.05
Close of Meeting
19.30
Meeting Dinner
Merchants Restaurant, Merchant’s Street (off Candlemaker Row)
Hosted by Neuroscience Honours Class
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Edinburgh Neuroscience Activities 2015
In December 2013 we submitted to the Research Excellence Framework (REF) an overview of our
neuroscience research activities in Edinburgh since 2008, and their societal impact, as part of a UK-wide
exercise in assessing the quality of UK research. After a year of waiting for all submissions to be
assessed by panels of experts, the outcomes were announced in December 2014. Much of the research
within Edinburgh Neuroscience was submitted to the ‘Psychology, Psychiatry & Neuroscience’ panel
alongside 82 other UK institutes who submitted to this panel.
Our overall performance confirms Edinburgh’s
FTE
status as one the UK’s elite Neuroscience
3*
2*
1*
u/c
submitted 4*
Institutes. We submitted a larger number of staff
than all other Institutes except UCL and KCL
Outputs
117.28
27.5 51.8 19.5
1.2
0.0
and increased our percentage of 4* (worldImpact
117.28
81.5 18.5
0.0
0.0
0.0
leading) outputs (publications) compared to our
2008 submission. We did extremely well on the
Environment
117.28 100.0 0.0
0.0
0.0
0.0
impact of our research with 81.5% of our case
studies rated as 4* and we received the
Overall
117.28
49
38
12
1
0
maximum score possible for the quality of our
research environment (100% 4*), which reflects
the interdisciplinary nature of our community and the support available at the University. When all these
factors were considered together (not just our research outputs) we were ranked 3rd in the UK for the
quality of our research power, sitting alongside UCL, KCL, Cambridge and Oxford in the top five.
Attracting Students
Edinburgh Neuroscience strives to
student neurology society, helping
Conference’, which took place in
Edinburgh Neuroscience members
provides undergraduates with a
showcases Edinburgh as a vibrant
attract outstanding students and in 2015 we once again supported our
to organise the ‘3rd National Neuroscience to Neurology Undergraduate
February. It was attended by 100 students from across the UK and
contribute to the talks, workshops and oral/poster judging. This forum
rare opportunity to present work from their research projects and
community which is an attractive place for postgraduate study.
Throughout the summer of 2014 Edinburgh Neurosocience worked with postgraduate administrators,
postgraduate academic coordinators and a student focus
group to develop a new communal advertising and
application portal system for PhD studentships in
neuroscience. This was intended to simplify the identification
of available PhD projects for students, to help staff
advertise projects in an effective and attractive manner and
to recruit the very best students possible. In November
2014 EdNeuro.PhD was launched and has proved very
popular with prospective students and postgraduate staff
alike. We have advertised a large number of projects from
all areas of neuroscience and over the last few weeks a
series of outstanding students have been offered PhD
places in Edinburgh.
This portal is available all year round for advertising
positions from across the university and should be the first
port of call for anyone with projects in the Centres for
Clinical Brain Sciences, Cognitive & Neural Systems,
Integrative Physiology, and Neuroregeneration.
Supporting Researchers
Edinburgh Neuroscience continues to find ways of supporting our researchers. As in previous years, in
addition to our annual Neuroscience Day in March, Edinburgh Neuroscience organised (in collaboration
with the Centre for Cognitive Ageing & Cognitive Epidemiology, CCACE) an ‘Autumn School for PhD
Students’ in October. This School brings together students from across the full neuroscience spectrum at
Edinburgh. This year, one interactive activity had them pitching ideas for ‘funding’ from a panel of
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experienced researchers – the winner wanted to tap into crowd sourcing as a means of funding a PhD
and was rewarded with free registration at the upcoming BNA Festival of Neuroscience meeting in April
(kindly donated by CCACE).
Our Neuroresearcher’s fund continues to support our early years researchers and in 2014 eight
researchers were funded to undertake a range of activities (£5,220 was allocated, see below). We are
delighted that the University of Edinburgh ISSF fund has contributed £5,000 to allow us to provide another
round of funding in April 2015 (call will open on 5th March and close on 30th April).
• Lynsey Hall (PhD Student, Psychiatry, Centre for Clinical Brain Sciences) was awarded £500 to attend
the ‘Wellcome Trust Advanced Course in Genetic Analysis of Multifactorial Diseases’ in Cambridge.
• Lucy Hiscox (PhD Student, Alzheimer’s Scotland Dementia Research Centre) was awarded £1,200 to
visit the University of Illinois to learn Magnetic Resonance Elastography (MRE).
• Mark Hughes (ECAT PhD Student, Centre for Integrative Physiology) was awarded £870 to visit the
Focused Ultrasound Foundation in Charlottesville, USA to learn a new technique, Trans-cranial
Magnetic Resonance-guided Focused Ultrasound (tcMRgFUS).
• Danai Katsanevaki (PhD student, Centre for Integrative Physiology) was awarded £1,000 to visit the
University of Mainz to learn how to combine imaging with optogenetic activation.
• Dominika Lyzwa (PhD Student, Informatics) was awarded £300 to visit the Laboratory of Auditory
Neurophysiology at the Hebrew University of Jerusalem to establish a new collaboration.
• Elitsa Peeva (PhD student, Centre for Regenerative Medicine) was awarded £500 to visit the European
Screening Port in Hamburg to learn about large scale proximity ligation assays for drug screening.
• Sarah Tennant (PhD student, Centre for Integrative Physiology) was awarded £500 to attend a oneweek training workshop at the Optogenetics Innovation Laboratory at Stanford University
• Sally Till (Postdoctoral Fellow, Centre for Integrative Physiology) was awarded £350 to visit Dr Chris
DeZeeuw’s laboratory at Erasmus University, to learn the conditioned eyeblink reflex technique.
Our International Partnerships
Our international partnerships continue to strengthen and
grow. There have been regular student and researcher
exchanges with the Brain Centre Rudolf Magnus (BCRM) in
Utrecht and, in November 2014, we had a very enjoyable joint
symposium in Utrecht.
Our students have benefited from
access to specialised courses run by the BCRM and a
delegation joined the ‘Current Issues in Clinical Neuroscience:
Epilepsy’ course in May 2014 and, in return, we have provided
opportunities for BCRM students to attend the stem cell and regenerative medicine course, also in May
2014. We are also delighted to welcome four students from the BCRM to Neursocience Day this year.
The joint PhD initiative with Aarhus University in Denmark now has two PhD students in post – Alexandra
Bannach-Brown (with Prof Malcolm Macleod in Clinical Brain Sciences) and Lena Martis (with Prof Megan
Holmes in Centre for Cardiovascular Sciences). Prof Andrew McIntosh (Centre for Clinical Brain Sciences,
Psychiatry) also has a third student, Ella Wigmore, who, although not on a formal joint PhD, will spend a
year of her project working in Aarhus. We have now started joining up our European collaborations by
working with Aarhus University and BCRM (with the addition of the Universita Degli Studi di Milano as the
fourth partner), to submit a Horizon 2020 Marie Curie Joint PhD Network application for 15 PhD
studentships across the consortia, working on stress-related neuropsychiatric disorders.
The Edinburgh collaboration with InStem and the National Centre for Biological Sciences (NCBS) in
Banglaore, India, reached a new phase in 2014 with the award
of £6 million from the Indian Government to create the ‘Centre
for Brain Development and Repair’ in Bangalore, India. This
Centre is led by Prof. Sumantra “Shona” Chattarji, a
neurobiologist at NCBS, with Edinburgh Neuroscience Board
members Prof Siddharthan Chandran and Prof Peter Kind both
Associate Directors. In February 2015 the Indian Prime Minister,
Narendra Modi, visited the new centre and Prof David Wyllie
(Centre for Integrative Physiology) was present, as he was on a
visit training PhD students at the time.
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Reaching Out
Our outreach and engagement programme reached more than 1,200 adults and children over the past
year through a wide variety of events including:
•
Three public lectures : 1) Our Christmas Lecture by Prof Gareth Leng (Centre for Integrative
Physiology) on the neuroscience of obesity.
2) Our ‘Mindfulness for Depression’ lecture tour in
collaboration with the Global Health Academy and the British Science Association (BSA) Edinburgh
branch. This event was very successful and won the BSA award for the best UK European Year of
the Brain event. 3) A public lecture celebrating the life of the Edinburgh Anatomist George Romanes.
All talks are available online at our YouTube channel (www.youtube.com/user/EdNeuro).
•
Science Festivals : We contributed to the inaugural ‘Mad Hatters - Grey Matters’ festival in Fife in
July with drop-in stands and talks, and our involvement has left a legacy of regular science talks for
the local community. We joined the Midlothian Science Festival in October, delivering getBRAINY
workshops, drop-in gala-day stands, simulated neurosurgery workshops and a film evening. Many
members also contributed to the Edinburgh Science & Fringe Festivals, reaching even more people!
•
Film evenings : at Cineworld, Fountainbridge with the British Science Association Edinburgh branch
•
School visits : our getBRAINY workshops (getCONNECTED & getREMEMBERING) were out and about,
and there were visits to schools by individual researchers. We are also providing advice to the Max
Planck Institute for Brain Research (Frankfurt) as they develop their own getBRAINY workshop series.
•
Art & Neuroscience : Following last years Innovative Learning Week art-neuroscience workshop, we
secured funding to set up a monthly group and, in October 2014, the FUSION group was launched,
bringing together neuroscientists, psychologists and the Edinburgh College of Art. As a result, three
FUSION members from the ECA are exhibiting their neuroscience-inspired work at Neuroscience Day
2015. Please take a moment to go and have a chat with them. Find us on Facebook and Twitter!
W orking with Other Organisations
Edinburgh Neuroscience members have been very busy attracting large neuroscience meetings to Scotland
and taking active roles in making them a success. The British Neuroscience Association (BNA) Festival of
Neuroscience will be taking place in Edinburgh in a few weeks (12th – 15th April 2015), and our researchers
have enthusiatically embraced the arrival of our national meeting (the first time a BNA meeting has taken
place in Scotland). They have contributed many symposia to the scientific programme, are speaking at the
meeting and organising satellite events. In future years we have Euroglia to look
forward to, as this extremely successful themed meeting has, in recognition of the
strength of glial research in Edinburgh, been awarded to Edinburgh in 2017.
Further into the future the FENS FORUM has been awarded to Glasgow for 2020.
Edinburgh Neuroscience members were all crucial in securing these meetings.
In a new approach to working across boundaries, Edinburgh Neuroscience also
brought together the BNA and the Edinburgh International Science Festival (EISF),
and worked with them to jointly develop a dedicated programme of neurosciencethemed activities for the science festival.
Brainwaves will run throughout the
Science Festival (4th – 19th April 2015) but peak over the BNA meeting weekend.
In conclusion it has, once again, been a diverse, interesting, and very successful year for neuroscience at
Edinburgh. This is a result of the enthusiasm and dedication demonstrated by the researchers and support
staff that make up our vibrant neuroscience community – Thank You!
And com ing later this year…….. O ur ‘Ages of the Brain’ m ini-m ovie!
For one week in May 2015, we will be asking the Edinburgh Neuroscience community to contribute video
clips and ideas for a short film highlighting our research across Edinburgh. We would like to showcase the
breadth of work across the life course of the brain (from first beginnings to death), and use the span of
our normal working week to bring it all together. Edinburgh Neuroscience will be working with Dr Robin
Morton (Centre for Cognitive Ageing & Cognitive Epidemiology) to help you all submit your short video
clips and ideas over the course of one single week in May!, The clips can be of any quality, even filmed
on a mobile phone, as long as they capture the essence of the work of Edinburgh Neuroscience. We will
then turn all your contributions into a short movie. I hope you will all enthusiastically take up this
challenge – it should be lots of fun and, who knows, we might even end up with a viral video!
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Round-up of Centre Activities
Centre for Clinical Brain Sciences
There have been many changes to CCBS in the last year,
most notably the new office suite in the Chancellor’s Building,
where many Clinical Neurosciences and Neuroimaging Sciences
groups are now based. Our website (www.ccbs.ed.ac.uk) was
given a complete overhaul and we finally joined Twitter
(@EdinUniBrainSci).
Clinical Neurosciences (and friends)
Notable grant successes include renewal of the Cochrane
The newly refurbished CCBS office suite in
Stroke Group infrastructure grant (CSO, Mead), the European
Chancellor’s Building, Little France.
Prevention of Alzheimer’s Dementia Initiative (10 European
countries, led by Ritchie), the Dementias Platform UK (MRC,
work-strands led by Ritchie/Sudlow/ Deary), renewal of the National Creutzfeldt-Jakob Disease Research &
Surveillance Unit (Department of Health, Knight et al), the Edinburgh Brain Bank (MRC, Smith/ Ironside), MS
Centre for Translation Research (MS Society, Chandran/ ffrench-Constant), perinatal brain injury
(TheirWorld, Boardman), MS Challenge Alliance / MS Society (Mahad), and the retina in dementia (EPSRC;
Dhillon/ MacGillivray/ Wardlaw/ Deary).
“The eye as a window to the brain” is an
emerging theme of CCBS research
With over 300 CCBS publications in the last year, it is
impossible to credit all the researchers for their excellent work.
There were over 20 publications in the Nature and Lancet
journals alone, including genes influencing brain size (Nature –
many
researchers
from
Psychiatry,
Neuroimaging
&
Neuropathology); thrombolysis in stroke (Lancet x 2 – Stroke
group); mutations in schizophrenia (Nature x 2 – S Grant,
Komiyama); stem cell-derived models of MND (Nature Comm Chandran); mechanisms of MS (Lancet Neurology – Mahad);
brain gene expression variability (Nature Neurosci - Smith) and
the Waste in Research series (Lancet - Salman, Macleod).
Clinical trials are an important part of our remit, and numerous new trials were funded or published
findings, including MS-SMART - re-purposed drugs in progressive multiple sclerosis (Chandran); CODES cognitive behavioural therapy for non-epileptic seizures (Stone/Carson); FOCUS - Fluoxetine in stroke
(Dennis/Mead/Macleod); IST-3 – thrombolysis in stroke (Sandercock/Dennis/Wardlaw); ARUBA - brain
arteriovenous malformations in stroke (Salman); CLOTS3 – compression stockings in stroke (Dennis);
EuroHyp – cooling in stroke (Macleod/Wardlaw); and cannabis extract for childhood epilepsy (Chin/Muir
Maxwell Epilepsy Centre).
Our research and trials continue to shape clinical practice: CCBS contributed nine of the thirteen
Neuroscience impact statements to the REF last year. Our work has resulted in changes to diagnostic and
treatment guidelines and practice worldwide, particularly in stroke, prion diseases and functional disorders.
There were personal successes for Stone (renewal of NRS fellowship, Jean Hunter Prize for Nervous
Diseases from the RCP), Barugh (Wilfred Card Lectureship), Brennan (Lancet Young Investigator Prize),
Woodfield (WT Clinical Lectureship); Lerpiniere (nomination for Research Nurse of the Year); Tieges and
Davidson (poster prizes at national meetings). The Edinburgh Exercise after Stroke Pathway won the NHS
Lothian Best Innovation prize; the “Stem Cells, Neurodegenerative Diseases and Models course, organised
by Hampton, won EUSA’s ‘Best Course’ award. Sudlow is Chief Scientist of UK Biobank and R Grant leads
the James Lind Alliance Brain and Spinal Cord Tumour Priority Setting Partnership.
We would like to welcome our new PIs — Ritchie (Chair of the Psychiatry of Ageing), Fletcher-Watson
(Chancellor’s Fellow); clinical fellows Chun, Humphreys, Blair (Princess Margaret Research Fellows) and
Mollison (Rowling Scholar); postdocs and PhD students (three of whom won Principal’s Career Development
Fellowships).
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Outreach remains an important part of our remit. Our PIs lectured
at the Edinburgh International Science festival on stroke (Mead) &
multiple sclerosis (Weller), took part in the Cabaret of Dangerous
Ideas at the Edinburgh Fringe (Stone, Lawrie), lectured in the Medical
Detectives series (Sandercock, Chin), manned awareness stands in
the Royal Infirmary and/or at Anne Rowling Regenerative Neurology
Clinic open evenings (Euan MacDonald Centre, Patrick Wild Centre,
Muir Maxwell Epilepsy Centre, RUSH team), and contributed to
numerous media articles (including Radio 4’s Woman’s Hour). Our
public-facing
websites
(euanmacdonaldcentre.com,
At a patient-scientist exchange event,
annerowlingclinic.com,
muirmaxwellcentre.com,
Genes2Cognition,
lab members got an idea of how it
neurosymptoms.org) and social media are gaining in hits. Check out
feels to breathe if you have motor
the Muir Maxwell Epilepsy Centre’s successful #lovelistsMMEC
neurone disease.
awareness campaign! The ice bucket challenge, The Theory of
Everything film, campaigning by Gordon Aikman and high-profile
support by comedian Kevin Bridges have made it an incredible year for motor neurone disease awareness
and fundraising. The Euan MacDonald Centre for MND Research is busier than ever, with new PIs in
Edinburgh, Aberdeen and Glasgow (now 34 in total), visits from the press and documentary-makers and an
uplifted sense of collaboration and opportunity.
Neuroimaging Sciences (NiS)
In 2014, staff produced papers in the Lancet (2), Nature and
numerous outputs in specialty journals reporting on neuroimaging
associations in stroke, ageing, genetics of brain structure, white
matter disease, smoking and impact on treatments for stroke.
Muir
Maxwell
Trust
and
(http://bit.ly/ProfWardlaw).
The replacement of the Brain Research Imaging Centre scanner with
a new facility embedded in the Royal Infirmary adjacent to A+E, ITU,
Radiology and the new DCN/RHSC wing is now in the building
phase. The scanner will be installed and working by spring 2016.
Funds for the scanner have been obtained from the Wellcome Trust,
Dunhill Trust, Edinburgh and Lothians Endowment, TheirWorld, the
various
other
donors.
The
fundraising
campaign
continues
Grants for research to improve early diagnosis of dementia from EPSRC and TSB, from MRC for a further
wave of scanning the Lothian Birth Cohort, from MRC CRII for an MR-PET scanner as part of Dementia
Platform UK, and the JPND for enhancing cohorts in Europe to study neurodegeneration, were awarded.
Our brain MR images were BMJ Picture of the Week and contributed about 6% of world data to genetics
consortia publications. We showcased the wider environment of excellence and strengths of Edinburgh
Imaging in clinical imaging, pre-clinical imaging, experimental imaging, microscopy and imaging sciences
(http://youtu.be/CDXT-2QhgS8). Further details see www.ed.ac.uk/edinburgh-imaging, please email
[email protected] for mailing list, courses, student fora, analysis workshops, etc).
The Edinburgh Imaging Academy in 2014, launched the online MSc Imaging, alongside the MSc
Neuroimaging for Research. We received excellent feedback from all students; matriculated students exceed
projected intake for Year 2. 2015 will see new online CPD and PPD courses. Meanwhile courses are
available to existing UoE PhD students (http://bit.ly/EdinPhD), a SPM Workshop in Edinburgh (27th April 1st May 2015, http://bit.ly/EdinSPM), a UoE Image Analysis Workshop Autumn 2015, and Heriot Watt’s
ESRIC Super-Resolution Summer School (3rd - 7th August 2015).
Psychiatry
Three new PIs joined us this year. Craig Ritchie is Professor of the Psychiatry of Ageing, while Sue
Fletcher-Watson and Kristin Nicodemus are Chancellor’s Fellows doing research on developmental disorders
and genomic architecture of major psychiatric disorders respectively.
All three have started very
dynamically, bringing in grants and attracting new PhD students and other staff but Sue’s blog, Kristin’s
paper in JAMA Psychiatry and Craig’s massive grant deserve special mention.
Andrew McIntosh, with colleagues across CCBS and EN, successfully obtained £5M from the Wellcome
Trust for a project called STRADL, which aims to stratify depression. Victoria Barker, lecturer in general
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adult psychiatry, won the Margaret Temple grant from the BMA to study
childhood maltreatment and epigenetic processes in schizophrenia. Tom Russ,
lecturer in Old Age Psychiatry, got an Academy of Medical Sciences starter
grant to examine urinary proteomic profile as a biomarker for cognitive
decline and dementia in the LBC1947 cohort. Tom, and Kyla Brown (PhD
student with Adrian Bird), have won places on ECNP training courses in old
age and child psychiatry. Lynsey Hall (PhD with Andrew McIntosh) won a World
Congress of Psychiatric Genetics Oral Presentation Award in Copenhagen, and
Cathy Bois (PhD with Stephen Lawrie) has won a place and will talk at the
ECNP training course in Neuropsychopharmacology.
Several members of the department contributed to the Schizophrenia GWAS paper in Nature, published in
July 2014, which reported 108 separate loci over-represented in >30,000 patients compared to >110,000
controls. Many of us, together with many others from CCBS and EN, also contributed to the very recently
published ENIGMA2 paper in Nature which pooled imaging and genetic data from 30,717 individuals from
50 cohorts worldwide and identified five novel genetic variants influencing the volumes of the putamen
and caudate nucleus.
Many members of staff have contributed to numerous public engagement events over the past year.
Andrew Stanfield and Mandy Johnstone contributed to the Midlothian Science Festival. Together with
colleagues from Clinical Psychology, EN and the Global Health Academy, Stephen Lawrie did a British
Science Association award-winning travelling workshop on mindfulness for depression.
Centre for Cognitive Ageing & Cognitive Epidemiology
The Centre for Cognitive Ageing and Cognitive Epidemiology’s (CCACE) (www.ccace.ed.ac.uk/) aim is to
understand the reciprocal influences of cognition and health across the human life course and between
generations. CCACE is an international leader in the crucial field of Cognitive Ageing and the growing field
of Cognitive Epidemiology.
CCACE is now well into its second 5 year phase of funding from the Medical Research Council Lifelong
Health and Wellbeing (LLHW) initiative, which represents a £9.2m investment by LLHW and the University of
Edinburgh. CCACE now has over 70 members, 9 currently funded PhD students (with a further 9 having
now completed their PhD) and 10 core staff. With over 1,000 papers published by Centre members since
CCACE’s inception in September 2008, CCACE has gained an international reputation for being at the
forefront of research on the brain and the genetics of cognitive ageing.
CCACE members have been instrumental in obtaining research funding of benefit to the wider University.
This includes £1m funding from the BBSRC for whole genome sequencing of the Lothian Birth Cohort
1936, £4.7m funding from the Wellcome Trust to carry out a 5-year study to better classify and
understand individuals with low mood (STRADL) and £6.8m from the MRC-funded Dementias Platform UK
for a new high resolution (PET-MRI) scanner to help investigate what is happening in the brain during
dementia. CCACE has four members on the steering group of the Demetias Platform UK, and Ian Deary is
one of the five UK academics on it's Executive Committee.
Research by CCACE members and collaborators has continued to achieve
international standing and has received considerable press attention. For
example, CCACE researchers demonstrated an association between
childhood reading ability and higher intelligence in twins, supporting the
positive effect that schooling and learning to read in particular has on
later intelligence. CCACE member Thomas Bak published a study
suggesting that learning two languages benefits the ageing brain and
delays the onset of dementia. Other CCACE researchers found an
association between height and risk of dementia and job complexity and
cognitive decline, suggesting that holding more mentally taxing jobs such as lawyer, doctor or teacher may
protect against cognitive decline in later life. January 2015 has seen a bumper crop of high profile
papers, with links between DNA methylation and mortality, smoking and cortical thickness and the
discovery of 4 genes for cognition.
The Lothian Birth Cohorts continue to enjoy a high scientific and media profile. The Cohorts featured in
a 4-page spread in Science Magazine (July 2014). In April 2014 over 400 Lothian Birth Cohort (LBC)
participants gathered for a reunion to hear some early results from the latest phase of testing and future
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plans for the project. The reunion also incorporated a screening of a new film, “The Living Brain” by
Anne Milne. STV took the opportunity to highlight the project on their evening news slot. The project
also featured on Frontiers on BBC Radio 4 and more recently BBC Breakfast. CCACE also broke new
ground by becoming a publisher of “Lifetimes” by Ann Lingard, a book of short stories about the cohorts..
In April 2015, CCACE hosted an expert workshop on the topic of processing speed, bringing together 11
international experts to discuss new results linking processing speed to intelligence, the brain and genetic
differences. The workshop was funded by the British Academy and coincided with the BA debate “The best
years of our lives? Brain, body and well-being”, at which CCACE director Professor Ian Deary presented
results from the Lothian Birth Cohorts and debated how genes, environments and lifestyles affect our
older selves.
In addition to its academic research, CCACE and its members are involved in a lively programme of public
engagement and knowledge exchange events. In August 2014, CCACE
member Alan Gow performed a new show “Brain Training on Trial” to a
packed out audience at the Edinburgh Fringe.
You can find out more about CCACE, its achievements and upcoming
events by visiting www.ccace.ed.ac.uk or following CCACE on Twitter
(@ccace), Facebook (@ccaceEdinburgh) or YouTube (@ccaceVideo).
Centre for Cognitive & Neural Systems
It has been primarily a year of consolidation for CCNS with our three Chancellor’s Fellows already
appointed last year, but now with their laboratories up and running, grants coming in and with postdocs
and Ph.D students appointed and their work underway. There is a real buzz in 1 George Square and this
is reflected in several ways. First, in our “Food for Thought” seminars in which the younger scientists
present what they are working on internally for comment and discussion (thanks to Tara Spires-Jones for
getting this going); and to a very lively set of External Seminars in which outside speakers came and
discussed work relevant to our research themes of cognition and disorders of cognition (thanks to Iris
Oren for organising these last year).
Richard
Morris
was
privileged to win a Royal
Medal for Science from
the
Royal
Society
of
Edinburgh in 2014, but far
and away the greatest
success was to two former
postdocs – Edvard and
May-Britt Moser.
They
worked within the group
May-Britt receiving her Nobel Prize from the King of Norway
here for two years in the
and Richard Morris with Edvard Moser at the Nobel Prize Dinner.
mid-1990s, primarily with
Richard Morris, and then
returned to their home country Norway to set up a wonderfully successful small laboratory in Trondheim
where they made the seminal discovery of “grid-cells”. With Professor John O’Keefe of University College
London, Edvard and May-Britt were recipients of the 2014 Nobel Prize for Medicine or Physiology. Richard
attended the ceremony in Stockholm – a truly unique event.
Centre for Genomics & Experimental Medicine
The Centre for Genomics and Experimental Medicine, in the Institute for Genetics and Molecular Medicine,
has had a busy year, which culminated in the award of the Fondation IPSEN Neuronal Plasticity Prize for
2015 awarded David Porteous. This prize has been awarded annually since 1990 to three researchers
and David’s co-awardees are Thomas Bourgeron, Institute Pasteur, France and Mark Bear, MIT, USA. Past
winners include this year’s distinguished speaker Huda Zoghbi (2004) and our own Richard Morris (2013).
Of the 75 awardees to date, David is the 8th UK based researcher (Tim Bliss, NIMR (1), Trevor Robbins,
Wolfram Schultz and Barry Everitt, Cambridge (3), Richard Frackowiak and John Morton, UCL (2), David
Porteous and Richard Morris, Edinburgh(2)).
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There have been a number of major funding awards including a
Wellcome Trust Strategic Award for ‘Stratifying Resilience and
Depression Longitudinally (STRADL)’.
This £4.8M, 5 year grant
(which started in January 2015) was awarded to Andrew McIntosh,
David Porteous, Ian Deary, Kathy Evans, Chris Haley, Jonathan
Seckl, Stephen Lawrie, Joanna Wardlaw (all Edinburgh) and Alison
Murray (Aberdeen) (IGMM co-I’s underlined). The aim of this project
is to identify lifecourse events, cognitive and behavioural traits,
structural and function brain features, genetic makeup and
epigenomic change that interact to influence resistance or
susceptibility to major depressive disorder and cardiometabolic comorbidities.
It will increase the number of Generation Scotland
participants who have comprehensive genetic annotation (Illumina OmniExpress SNP and exome chip GWAS)
from 14,000 to 20,000, of which 3,000 will be selected for detailed clinic based analysis and for structural
and functional MRI. We will also biobank biological materials (DNA, RNA, plasma, hair plucks) for analysis
downstream.
The Deciphering Developmental Disorders (DDD) study aims to use new genomic technologies to improve
the diagnosis of developmental disorders in children. It is a collaboration between the NHS clinical
genetics services, the Wellcome Trust Sanger Institute and families across the UK. It is led by Matt Hurles
(Sanger Institute). David Fitzpatrick is co-I and lead for Scotland. The first 1,000 of a planned 30,000 total
cases have been sequenced and the results published in Nature. The study re-discovers known genes and
mutations, known gene and new mutations and discovers multiple novel genes and pathological mutations.
As well as providing cases and analysis, Edinburgh has provided well matched controls from ORCADES
(Jim Wilson, CPHS) and Generation Scotland (David Porteous, CGEM) for confident ascertainment that novel
variants are mutations not natural polymorphisms. A second study in Lancet (2014) describes the clinical
impact in more detail.
DDD references
1) Deciphering Developmental Disorders Study ‘The Deciphering Developmental Disorders Study’, Nature 24th
December,
2014
(Epub
online]
PUBMED:
25533962;
DOI:
10.1038/nature14135
2) Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF, van Kogelenberg M, King DA, Ambridge K,
Barrett DM, Bayzetinova T, Bevan AP, Bragin E, Chatzimichali EA, Gribble S, Jones P, Krishnappa N, Mason
LE, Miller R, Morley KI, Parthiban V, Prigmore E, Rajan D, Sifrim A, Swaminathan GJ, Tivey AR, Middleton A,
Parker M, Carter NP, Barrett JC, Hurles ME, FitzPatrick DR, Firth HV and on behalf of the DDD study
‘Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide
research data.’ Lancet 2014 PUBMED: 25529582; DOI: 10.1016/S0140-6736(14)61705-0
Other recent CGEM papers
1) Davies G, et al., Genetic contributions to variation in general cognitive function: a meta-analysis of
genome-wide association studies in the CHARGE consortium (N=53  949). Mol Psychiatry. 2015 Feb 3. doi:
10.1038/mp.2014.188. [Epub ahead of print] PubMed PMID: 25644384.
2) Rietveld CA, et al., Common genetic variants associated with cognitive performance identified using the
proxy-phenotype method. PNAS 2014 Sep23;111(38):13790-4. doi: 10.1073/pnas.1404623111. Epub 2014
Sep 8. PubMed PMID: 25201988; PubMed Central PMCID: PMC4183313.
Centre for Integrative Physiology
The Centre for Integrative Physiology researches fundamental physiological mechanisms and pathways,
from single genes to complex behaviour, relevant to normal human function and how disruption of these
mechanisms lead to disease. Research is focused around two broad themes: Signaling, cells and networks
addressing how cells communicate and control complex behavior and, Development, degeneration and
regeneration understanding how organs are built from cellular networks, how these networks fail and how
we can repair them.
In 2014 CIP welcomed Maria Doitsidou as a new Chancellor’s fellow and four new academic Fellows: Barry
Denholm, Dawn Livingstone, Karen Smillie and Paul LeTissier. In addition we welcomed the new IMPACT
imaging facility manager Dr Anisha Kubasik-Thayil.
CIP was again successful in attracting an array of new Fellowships in 2014. Emily Osterweil, one of our
new Chancellors Fellows, was awarded a Wellcome Trust /Royal Society Sir Henry Dale Fellowship to study
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the differential regulation of protein synthesis in synaptic plasticity and autism spectrum disorders. Dr
Sophie Thomson has been awarded a Junior Fellowship grant from the Tuberous Sclerosis Association to
investigate targeting of the mGluR5-FMRP signaling pathway for the treatment of TSC. Dr Ewout Groen has
been awarded a Sir Henry Wellcome Postdoctoral Fellowship to work in Tom Gillingwater’s lab to support
his research on changes in ubiquitin homeostasis in motor neuron disease. Dr Sarah Gordon who has
been awarded a New Investigator Grant from the Australian National Health and Medical Research Council.
In addition Dr Alfredo Gonzalez-Sulser, Dr Janelle Pakan and Dr Idoia Quintana joined CIP as new Marie
Curie IIF and/or IEF fellows. Matt Nolan with colleagues in Germany and USA was awarded a Human
Frontiers Science Programme award and Tom Gillingwater was part of a new £2.5M European consortium
(AxonomiX), which will identify the translational networks altered in motor neuron diseases.
Some
of
our
research
highlights
included:
Alastair
Garfield’s
characterization of a parabrachial-hypothalmic neural circulate that
controls counterregulatory responses to hypoglycaemia (Cell Metab
20:1030-1037) and an excitatory hypothalamic neural circuit that drives
hunger (Nature 507:238-242). Andy Jarman’s lab, in collaboration with
colleagues in MRC HGU, characterised HEATR2 as a candidate gene in
primary cilia dyskinesia (Plos Genet 10(9):e1004577). Tom Gillingwater’s
lab revealed that dysregulation of ubiquitin homeostasis and b-catenin
signaling promote spinal muscular atrophy (J Clin Invest 124:1821-1834).
Barry Denholm revealed how organ shape is sculpted during development
and how cells sense the direction in which they should move (Plos Biol
12:e1002013). Dave Price’s lab discovered that diencephalic patterning is
controlled by a cell autonomous repression of sonic hedgehog at the central diencepahilc organizer (Cell
Reports (8:1405-1418). Dawn Livingstone and colleagues showed how the disruption of the enzyme 5αreductase 1 results in the development of metabolic risk factors. Emanuel Busch with colleagues in
Cambridge have discovered that a different diet can cause changes in the architecture of the vasculature
which then plays a role in the regulation of the metabolism (Cell 156:69-83).
On a broader note Edinburgh was ranked 1st in Scotland and 2nd in UK for Anatomy & Physiology
education in the Guardian University league tables.
Patrick Wild Centre
2014 was another successful year for the Patrick Wild Centre for
Research into Autism, Fragile X Syndrome & Intellectual Disabilities,
with a particular highlight being the opening of the Shirley Imaging
Suites by the Chancellor of the University. The new laboratories
contain two 2-photon microscopes for the in-vitro and in-vivo study
of models of autism.
We were also delighted to welcome four new
Chancellors Fellows to the Patrick Wild Centre, bringing their
expertise in the study of autism and intellectual disabilities to
Edinburgh: Drs Nathalie Rochefort, Christos Gkogkas and Emily
Osterweil on the laboratory science side, and Dr Sue Fletcher-Watson on the
clinical side. The first clinical trials of new medications for fragile X syndrome,
which we led in the UK, were also completed and reported last year.
Public engagement remains a key focus of the Centre; as well as our annual
meeting for supporters of the Centre, we also held some very successful public
engagement events. The Brain is Wider than the Sky exhibition in St Andrews
Square, held in collaboration with Mindroom, highlighted the beauty and
complexity of brain science and attracted large numbers of viewers as well as
international press attention. A separate exhibition held at the Edinburgh College
of Art, in collaboration with the Scottish Society of Architect Artists, was also
highly successful in raising funds and awareness for fragile X syndrome.
Centre for Neuroregeneration
This year we welcome Leah Herrgen as our newest Chancellor’s Fellow. Leah is joining us from the
Pharmacology Department, Oxford University. Leah’s interests are in the response of the developing brain
to injury using the zebrafish as a model (and it is not true that you have to be German and work on
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Leah Herrgen, CNR
Zebrafish to get a Chancellor’s Fellowship in CNR). The embryonic brain has an
astonishing regenerative capacity that allows it to recover from injury quickly and
completely. Leah will be studying underlying molecular and cellular mechanisms
with the aim of developing novel therapeutic approaches to brain injury. Another of
our Chancellor’s Fellows, Dirk Sieger, has got off to a great start after being
awarded a highly competitive Cancer Research UK Career Establishment Award
providing 6 years of funding. Other members of CNR continue to be successful in
winning major awards including a Wellcome Senior Fellowship to Dave Lyons and a
major microscopy equipment grant award from BBSRC led by Catherina Becker.
A number of dementia related programmes have received support this
year. Professors Karen Horsburgh will lead an Alzheimer‘s Society Doctoral training programme on the
theme of 'Metabolic and vascular contributors to dementia'. With colleagues in St Andrews and Dundee,
she was also awarded an Alzheimer’s Research UK Scotland network grant which aims to foster
interactions, collaborations and dialogue across the universities in dementia research as well as promoting
public engagement and awareness.
After 5 years as Head of Centre, Peter Brophy has stepped down and he will be succeeded by Catherina
Becker
Centre for Regenerative Medicine
The Centre for Regenerative Medicine (CRM) neuroscience teams have had a very successful 2014 in terms
of research findings, grants awarded, new links with pharmaceutical companies and with public
engagement. Our work continues into investigating mechanisms of neural stem cell biology and myelin
formation (Charles ffrench-Constant), understanding and manipulating remyelination after injury (Anna
Williams), investigating human diseases by using iPS cell generated neural/glial cells (Siddharthan
Chandran), studying the generation and behavior of dopaminergic neurons from human stem cells that
may be useful in Parkinson’s disease (Tilo Kunath) and investigating the biology and possible therapies for
glioma (Steve Pollard).
The MS Society has renewed their funding for the MS Centre (Siddharthan Chandran, Charles ffrenchConstant and Anna Williams are located in CRM) which will help advance knowledge and manipulation of
human cells from MS patients in culture and the pathology of MS from post mortem tissue, helped by
funding for a Edinburgh-based Scottish MS tissue biobank. Moving further still into potential translation of
our research into therapies, Anna Williams and Scott Webster (from the Centre of Cardiovascular sciences)
have forged links with the pharmaceutical company Sanofi-Genzyme, to identify small molecule inhibitors of
the Semaphorin3A-Neuropilin1 signaling pathway, with the aim of
developing a drug to improve CNS remyelination in diseases such
as multiple sclerosis. We are maintaining our public engagement
profile with several visits to CRM by groups of people with MS and
Parkinson’s disease to see our institute, hear about the research
going on, and also talks by our visitors telling our young scientists
what it is like to have neurodegenerative diseases, which have
been very popular on both sides.
Happy after Sanofi-Genzyme signed!
Clinical Psychology
The Edinburgh Research Group in Developmental Psychopathology based (http://www.eidp.hss.ed.ac.uk) in
Clinical Psychology is a group of clinical psychologists, academic developmental psychologists and
researchers interested in the application of theories and models of developmental psychology in a variety
of applied settings. The group comprises 6 Edinburgh based PI’s, and several postgraduates and early
career members of staff, as well as UK and international collaborators. Our research is mainly focused on
understanding risk and resilience in view of individual development, mental health and well being of
children and young people. We pursue these aims in experimental and basic scientific projects as well as
applied population based investigations and clinical trials.
Recent awards include FOCUS, a NIHR funded randomized controlled trial of psychological interventions for
individuals with clozapine resistant schizophrenia, including collaborators in Manchester, Glasgow, Newcastle
and Southampton; and YOUR (http://marc-web.psy.gla.ac.uk/YouR), an MRC funded study between Glasgow
and Edinburgh to identify biological and psychological factors that predispose individuals towards
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developing serious mental health problems, such as psychosis, using neuroimaging and clinical follow ups.
Both studies are supported by the Scottish Mental Health Research Network.
Some recent references
Taylor PJ, Pyle M, Schwannauer M; Hutton P; Morrison A (2015, in print). Confirming the structure of
negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal
Beliefs about Experience Questionnaire (PBEQ) and Personal Beliefs about Illness Questionnaire (PBIllQ). Br
Kinderman P, Schwannauer M, Tai S, Pontin E, Jarman I, Lisboa P (2015, in print). Different causal
and mediating factors for anxiety, depression, and well-being, Br J Psychiatry. BJP/2014/147553
Gumley, A. I., Schwannauer, M., Macbeth, A., Fisher, R., Clark, S., Rattrie, L., ... & Birchwood, M. (2014).
Insight, duration of untreated psychosis and attachment in first-episode psychosis: prospective study of
psychiatric recovery over 12-month follow-up. Br J Psychiatry, 205(1), 60-67.
The Roslin Institute
Congratulations to Paula Brunton and Barry McColl on achieving group leader status at the Roslin Institute.
Paula Brunton's group have been investigating the central mechanisms underlying dysregulation of the HPA
axis
in
rats
born
to
mothers
exposed
to
social
stress
during
their
pregnancy
(http://www.jneurosci.org/content/35/2/666.full). Barry
McColl’s
group
have
been
studying
how
neuroimmune mechanisms support normal brain function and contribute to acute brain injury and
neurodegeneration.
We are also pleased to announce that a world expert in comparative
neuropathology, Professor Pedro Piccardo, has joined the Institute.
The Neurobiology Division at the Roslin Institute aims to identify the key mechanisms that preserve healthy
brain function and those that contribute to neurodegeneration. Our location on the Easter Bush Campus
along with the R(D)SVS enables us to undertake research using a wide array of species. Selected highlights
from this year include successful funding for Danielle Gunn-Moore to extend our use of companion
animals in neurodegenerative research. Fiona Houston, Jean Manson and Abigail Diack have been using
sheep and mouse models to study the risks of human prion disease transmission through blood
transfusion
and
assess
transmission
characteristics
(http://wwwnc.cdc.gov/eid/article/20/12/14-0214_article.
Wilfred
Goldman’s group have performed a GWAS revealing major genome
differences between scrapie resistant and susceptible sheep. This will
allow selection of gene variants that may play a role as modulators of
prion disease and neurodegeneration. Tom Wishart, Bruce Whitelaw
(Roslin) and Paul Skehel (CIP) are currently generating a porcine model
for a rare neurodegenerative condition to aid in our understanding of
that disease and provide a more biologically relevant system in which
to carry out preclinical therapeutic trials. Simone Meddle and
collaborators at the University of St Andrews have demonstrated that
birds can learn to choose the best building materials for their nests
and have described the neuronal pathways involved in motor
sequencing, social behaviour, reward and motivation during nest
building (http://onlinelibrary.wiley.com/doi/10.1111/jne.12250/full).
The Roslin Institute also houses the MRC nPad (neurodegenerative processes of ageing and disease)
mouse network aiming to identify new genetic regulators of neurodegeneration. Several mouse lines are
now under investigation. The Bio-Imaging facility at the Roslin Institute has also recently undergone an
expansion. This facility provides imaging support in the form of highly specialised equipment, services and
advice to all Vet School staff, students and external researchers. This expertise culminated in Declan King
reaching the finals of the BBSRC Images with Impact competition (http://bbsrc2014.picturk.com).
The Roslin Institute hosted two successful meetings this year; the Scottish TSE Network Meeting discussing
‘Chronic Wasting Disease (CWD) pathogenesis and transmissibility’ and ‘Amyloidogenesis in vitro and in
vivo’ and ‘Neuroimmune interactions in CNS health, degeneration and repair’.
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Scottish
Mental Health
Research
Network
The SMHRN has been supporting high quality clinical
research across Scotland since 2009.
The SMHRN is funded by the Chief Scientist Office (CSO)
and our primary aim is to increase the quality and
quantity of mental health research throughout Scotland.
We currently support a large number of academic and
commercial studies in a range of clinical areas.
The SMHRN has a Scotland-wide Management Group
and is led from a co-ordinating centre in Edinburgh.
We have a dedicated team of Research Assistants and
Research Nurses based at the four main NRS Nodes
(North, East, South East and West).
We have developed partnerships with third sector
mental health organisations in Scotland and have
fostered strong links with research networks across the
UK.
Research development:
We can provide advice to researchers who are
developing research proposals or funding applications.
Study support:
Our team are trained in a range of skills such as clinical
interviewing, cognitive assessments and physical exams.
Patient and Public Involvement:
The SMHRN supports Patient and Public Involvement
(PPI) in research in a number of ways.
If you would like more information why not visit us at
our stand today or contact us at:
[email protected]
or phone
0131 537 6542
www.smhrn.org.uk
The Scottish Mental Health Research Network is funded by the Chief Scientist Office.
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Neuroscience Day 2015 Speakers
Huda Zoghbi
Professor of Pediatrics, Neurology, Neuroscience, and Molecular and
Human Genetics at Baylor College of Medicine and serves as an
Investigator with the Howard Hughes Medical Institute. She is also
the
Director
of
the
Jan
and
Dan
Duncan
Neurological
Research
Institute at Texas Children’s Hospital.
Email : [email protected]
Assistant : Elsa Perez ([email protected])
Website : www.bcm.edu/research/labs/huda-zoghbi
On the level: Equilibrium in the brain
Dr. Zoghbi Zoghbi’s interests range from neurodevelopment to neurodegeneration. Her discovery that
Spinocerebellar Ataxia type 1 is caused by expansion of a polyglutamine tract and that such expansion
leads to accumulation of the mutant protein in neurons has had profound ramifications since many
late-onset neurological disorders involve similar accumulations of disease-driving proteins.
Zoghbi’s
work in neurodevelopment led to the discovery of the gene Math1/Atoh1 and to showing that it
governs the development of several components of the proprioceptive, balance, hearing, vestibular, and
breathing pathways. Zoghbi’s group also discovered that mutations in MECP2 cause the neurological
disorder Rett syndrome. We now know that mutations in this gene are responsible for a broad
spectrum of disorders ranging from mild cognitive disabilities to autism. Her lab is focused on
understanding how loss of MeCP2 alters neuronal function to cause behavioral abnormalities. Zoghbi
trained many scientists and physician-scientists and is a member of several professional organizations
and boards. Among Dr. Zoghbi’s recent honors are the Pearl Meister Greengard Prize from Rockefeller
University, the Scolnick Prize from MIT, and the March of Dimes Prize in Developmental Biology. In
2000 she was elected to the Institute of Medicine, and in 2004 she was elected to the National
Academy of Sciences.
Nelson Cowan
Professorial Fellow, Psychology
Email : [email protected]
The role of general attention in working memory:
and neuroimaging evidence
cognitive
I completed my Ph.D. in 1980 at the University of Wisconsin and am Curators’
Professor at the University of Missouri, where I have worked since 1985. I am
currently also Professorial Fellow at the University of Edinburgh. Since the
beginning of college, I have been interested in understanding the human mind
and brain with respect to consciousness. With broad interests in perception,
attention, memory, and their childhood development, early on I settled on research on working
memory, the small amount of information one holds in mind while carrying out cognitive tasks. George
Miller proposed that there is a practical limit of about seven items in working memory and that we
circumvent that limit by combining stimuli to form larger mental chunks. Combining those two points,
my students, colleagues and I have suggested that there is a core, attention-based component of
working memory that can hold about 3 meaningful chunks in adults on average, and fewer in young
children. The capacity limit is important for most cognitive tasks. For example, the ability to
understand a new concept depends on the ability to hold in working memory all of the components of
that concept at once (e.g., a tiger as a large, striped cat). In pursuit of an attention-based view of
working memory, in addition to various articles, I have published two books: Attention and memory: An
integrated framework (1995, Oxford University Press), and Working memory capacity (2005, Psychology
Press). I have been funded by NIH for many years to examine the causes of improvement in working
memory throughout childhood..
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Christos Gkogkas
Chancellor’s Fellow, Centre for Integrative Physiology
Email: [email protected]
Translational control of gene expression in neuropsychiatric diseases
I studied biology and bioinformatics at the University of Athens Greece, then
proceeded to do an MSc in Neuroinformatics at the University of Edinburgh,
followed by a PhD in Molecular Neuroscience in Dr. Paul Skehel’s lab in the
Centre for Integrative Physiology. I then undertook a postdoc with Dr. Sonenberg
at McGill University Canada and since Oct 2013 became a Chancellor’s Fellow at
the Centre for Integrative Physiology and Patrick Wild Centre at the University of Edinburgh. My lab is
interested in understanding the mechanisms governing gene expression in the nervous system, mainly
at the level of protein synthesis, in neuropsychiatric diseases
Giles Hardingham
Professor of Molecular Neurobiology, Centre for Integrative Physiology
Signalling pathways to degeneration or resilience
Professor Giles Hardingham completed a BA in Natural Sciences at Sidney Sussex
College, Cambridge, followed by a PhD in molecular neuroscience at the MRC
Laboratory of Molecular Biology, under the supervision of Professor Hilmar Bading.
He then became a Fellow at Clare College and continued to work at the MRC. In
2002 he moved to the University of Edinburgh to pursue independent research,
first as a Royal Society University Research Fellow, and latterly as a MRC Senior
Non-Clinical research Fellow. His laboratory is interested in the core signaling pathways and gene
expression programs that influence neuronal health, both neurodegenerative processes as well as the
protective responses that help preserve neuronal function over many decades.
David Hunt
Clinical Fellow, Anne Rowling regenerative Neurology Clinic
Defining pathways which drive neuroinflammation
I am a Wellcome Trust Intermediate Clinical Fellow and consultant neurologist
with an interest in neuroinflammatory disease. My research focuses on the
identification of pathways which drive inflammation in the brain. I use patientderived material, neural stem cells and transgenic approaches to study these
disorders. I am currently working on understanding how activation on the innate
immune system drives inflammation and blood vessel damage within the brain. The aim of my work is
to identify the factors which trigger neuroinflammation, with a view to developing targeted treatment
strategies. I work closely with Professor Andrew Jackson at the Institute for Genetics and Molecular
Medicine and run a weekly clinic for patients with neuroinflammatory diseases at the Anne Rowling
Clinic.
Paul Hutton
Chancellor’s Fellow, Clinical Psychology
Understanding and improving treatment decision-making capacity in
psychosis
I completed my clinical psychology training in 2008 (University of Manchester),
after which I worked as a research clinical psychologist in the Psychosis Research
Unit (PRU) of Greater Manchester West NHS Mental Health Foundation Trust. Here
I provided psychological interventions to people with psychosis who had decided
not to take antipsychotic medication, within the context of Phase I and Phase II
NIHR-funded research trials. My current research interests are focused on understanding and improving
decision-making capacity and autonomy in psychosis, developing a greater range of treatment options
18
for this group, and developing and testing ways for prescribers to ensure service users with psychosis
are more involved in their care and treatment. I also carry out systematic reviews and meta-analyses
of randomised controlled trials of pharmacological and psychological approaches to psychosis. For
example, we recently published a meta-analysis of cognitive therapy for psychosis prevention, finding it
to be both effective and safe (Hutton & Taylor, 2013). I am in the process of setting up an
interdisciplinary research group focused on identifying the key gaps in our knowledge and
understanding of decisional capacity and autonomy in psychosis, and how these concepts relate to
patient definitions of recovery. We are trying to ensure this group has strong patient involvement from
the outset, which will help shape the longer-term goals of (a) developing and testing a model of
decisional capacity / autonomy in psychosis, and (b) developing acceptable, effective and safe
interventions to improve or support it.
Andrew Jackson
Professor of Human Genetics, MRC Human Genetics Unit
Growth, inflammation and the brain
Professor Jackson is a Programme Leader at the MRC Human Genetics Unit,
University of Edinburgh.
He is also an honorary consultant in Clinical
Genetics, and was elected as a member of EMBO in 2013, and as a fellow
of the Royal Society of Edinburgh, and the Academy of Medical Sciences in
2014.
He trained in Medicine in Newcastle, graduating BMedSci in 1990
and MBBS in 1993. His clinical and research postgraduate training was in
Newcastle, Leeds and Sheffield, with his PhD undertaken in the laboratory of Prof Geoff Woods on the
molecular basis of primary microcephaly.
Over the past 15 years his research has focussed on the identification of genes for inherited
neurological disorders and in defining the functional role of the proteins they encode. The Jackson lab
has discovered 12 human disease genes acting in growth and inflammation, all involved in fundamental
cellular processes. From a starting point of human disease, his research goal is to provide new
insights into basic biological processes..
Kristin Nicodemus
Chancellor’s Fellow, Centre for Genomics & Experimental Medicine
Novel Approaches to Understanding the Genomics of Psychiatric
Disorders
Dr. Nicodemus completed her Ph.D. in Statistical Genetics at the Johns
Hopkins Bloomberg School of Public Health and undertook a Postdoctoral
Fellowship and Career Development Fellowship at the University of Oxford
before being award a prestigious Science Foundation Ireland Starting
Investigator Grant to launch her first independent research group at Trinity
College Dublin. She is currently a Chancellor's Fellow and Senior Lecturer in
the Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine.
One focus of her research is in the genomic architecture of psychiatric disorders and cognition. To
unravel the complex genomics of risk in high-dimensional data she develops and applies machine
learning and other statistical algorithms to detect single genes of major effect along with polygenic and
epistatic components. A second focus is in the newly-emerging field of Computational Psychiatry,
including neuroeconomic game play.
19
Craig Ritchie
Professor of the Psychiatry of Ageing, Centre for Clinical Brain
Sciences
End-Stage Brain Failure: Prevention will be better (and easier to
achieve) than cure
Prof Ritchie is Professor of the Psychiatry of Ageing at the University of
Edinburgh having moved from his role as Senior Lecturer in the Centre for Mental
Health at Imperial College London in October 2014.
He is a leading authority on Clinical Trials in Dementia and has been senior investigator on over 30
drug trials of both disease modifying and symptomatic agents for that condition. This emerged from
his ongoing clinical leadership of the MPAC (Metal Protein Attenuating Compound) pipeline for Prana
Biotechnology dating back to 1998 when he worked as a Senior Visiting Research Fellow at the Mental
Health Research Institute in Victoria, Australia.
He has published extensively on the topics of dementia and delirium including clinical trials and metaanalyses. He sits on several advisory boards for major pharmaceutical and biotechnology companies as
well as The Wellcome Trust and the Public Health Steering Group for the Alzheimer’s Society. He is
also one of the leading editors in the Cochrane Collaboration’s Dementia Group with a particular
specialism in Diagnostic Test Accuracy reviews and is Assistant Editor for the journal International
Psychogeriatrics.
He is leading the PREVENT project; a major initiative nationally which will identify mid-life risks for later
life dementia and characterize early changes of neurodegenerative disease through imaging, genetic,
cognitive and biomarker analyses.
He also leads the EPAD (European Prevention of Alzheimer’s Dementia) Consortium which is a £50M IMI
funded, 5-year grant application to establish a Pan-European network of Trial Delivery Centers with
supporting infrastructure to undertake a perpetual, Proof of Concept multi-arm trial secondary trial for
secondary prevention of Alzheimer’s dementia. This work will be led from Edinburgh.
Stuart Ritchie
Research Fellow, Centre for Cognitive Ageing & Cognitive Epidemiology
Neuroanatomical changes and cognitive decline during the eighth decade
of life
Stuart Ritchie is a postdoctoral Research Fellow in the Centre for Cognitive Ageing
and Cognitive Epidemiology at the University of Edinburgh. He is interested in human
intelligence across the lifespan: how it develops and changes in both childhood and
old age, its neuroanatomical and genetic underpinnings, and how it might influenced
by factors such as education and social background. Recently, he has used statistical
techniques like structural equation modelling to investigate patterns of shared change in cognitive
abilities and the brain. For instance, using data from the Lothian Birth Cohort 1936, a large sample of
older adults living in Edinburgh and the surrounding areas with a wealth of lifestyle, health, cognitive,
and neuroimaging measures available, Stuart has modelled the shared longitudinal change in brain
white matter microstructure (from diffusion MRI) and fluid intelligence. His introductory book on
intelligence will be published by Hodder in June 2015.
Sergiy Slantyev
Chancellor’s Fellow, Centre for Clinical Brain Sciences
GABA-independent GABA-receptors: new factor in inhibitory signalling
Sergiy Slantyev is originally from Ukraine and since gaining his PhD in
Neuropharmacology he has undertaken postdoctoral work in Taiwan, Australia
and then the Institute of Neurology, University College London before taking up
his current position as a Chancellor’s Fellow in the Centre for Clinical Brain
Sciences. His research interests are in cellular and molecular neuroscience,
20
molecular pharmacology of neural receptors. His current research projects focus on the functional
characterization of spontaneously opening GABA-A receptors and also the rapid control of
neurotransmission by metabotropic glutamate receptors.
Catharine Ward Thompson
Professor of Landscape Architecture, Edinburgh College of Art
[email protected]
What does greenspace do to your headspace?
Catharine Ward Thompson is Professor of Landscape Architecture at the
University of Edinburgh and directs OPENspace - the research centre for
inclusive access to outdoor environments - based at the University of
Edinburgh and Heriot-Watt University (http://www.openspace.eca.ac.uk). She is
a qualified landscape architect and a Fellow of the Landscape Institute. She
has directed over £4m worth of research grants and projects since 2001. She has led several
multidisciplinary research collaborations investigating relationships between environment and health,
including I¹DGO (Inclusive Design for Getting Outdoors), which focused on access outdoors and quality
of life for older people. She has also led teams in developing innovative research techniques and
programmes to elucidate causal links between landscape and health, including the use of biomarkers
to investigate environment-body interactions and development of longitudinal studies based on natural
experiments to investigate the effects of environmental interventions on wellbeing. She was a member
of the Scottish Government¹s Good Place, Better Health Evaluation Group. In 2014 she was awarded
the European Council of Landscape Architecture Schools Outstanding Researcher Award for her
continuing contribution to European research. Current research includes a longitudinal study to
investigate the effects of woodland interventions on wellbeing in deprived urban communities in
Scotland, and work with older people - Mobility, Mood and Place – to explore how urban environments
can make active and healthy living easy and enjoyable for older people.
Emma Wood
Senior Lecturer, Centre for Cognitive & Neural Systems
Lumping and splitting: how
constrain spatial cognition
hippocampal place
cells
support and
Emma Wood received her PhD in neuroscience from the University of British
Columbia in Canada, where she worked with Prof Anthony Phillips investigating
memory in a rodent model of cerebral ischemia. After a postdoc at the
University of Oregon studying neural mechanisms of simple forms of learning in
the tobacco hornworm Manduca sexta, she did a second postdoc at Boston University with Prof
Howard Eichenbaum, where she used single unit recording techniques in freely moving rats to explore
spatial and non-spatial coding by hippocampal neurons. She then moved to Edinburgh where she runs
a joint research group in the Centre for Cognitive and Neural Systems with Dr Paul Dudchenko (Stirling
University). The lab uses an integrated approach combining behavioural analysis in rodents with in vivo
single unit recording, and various lesion, pharmacological and genetic techniques to address these
issues. In collaborations with members of the Patrick Wild Centre the lab is investigating mechanisms of
cognitive dysfunction in rat models of neurodevelopmental disorders (e.g. Fragile X syndrome).
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Neuroscience Day 2015 Poster Index
All posters should be manned during the am/pm breaks. During lunch there will be two sessions:
1) Even number posters from 12.50 - 1.20 pm
2) Odd number posters from 1.20 – 1.50 pm.
Please note that some posters are located on the large boards and not in numerical order.
* Entered into the PhD Student Competition
Full abstracts are online: www.edinburghneuroscience.ed.ac.uk/NeuroscienceDay/2015/abstracts/index.asp
Development and Regeneration
4* Pax6 and Barhl2 in the control of diencephalic development mediated by Shh
Parish EV, Mason JO, Shimogori T, Price DJ
5* The regulatory role of Pax6 on Cell Division Cycle Associated 7 protein and cortical
progenitor cell proliferation
Yu-Ting Huang, Da Mi, Katrin Ruisu, Asimina Pantazi, John O Mason, David J Price
6* Gli3 in the regulation of cortical progenitor differentiation
Alexandra Kelman
7
The role of the transcription factor Foxg1 in the preoptic area of mouse embryos
Covadonga Vara González Vassiliki Fotaki, PhD
8
The Role of 11β-Hydroxysteroid Dehydrogenase
Anxiety and Fear Memory
Khoo EJM, Phillip S, Harris AP, Holmes MC
9
Understanding wound repair and regeneration in the developing brain
Leah Herrgen
2
in
the
Prenatal
Programming
of
10* Cellular mechanisms of hippocampal regeneration
Rooney AG, Pollard S, ffrench-Constant C
11* The Role of Endothelin Signalling in Myelination
Matthew Swire, David Lyons, Charles ffrench-Constant
12
The polarity complex protein Scribble regulates myelination and remyelination in the
central nervous system
Andrew A. Jarjour, Amanda Boyd, Lukas E. Dow, Rebecca K. Holloway, Sandra Goebbels, Patrick O.
Humbert, Anna Williams, Charles ffrench-Constant
13* Directional Migration of Oligodendrocyte Precursor
Discovery and validation of novel candidate factors
Catriona B. Ford, Simon R. Tomlinson and Anna Williams
Cells
in
response
14* Enhancing OPCs recruitment through modulation of the Sema3A-NP1
pathway: increasing remyelination potential in multiple sclerosis
Elitsa Peeva, Scott Webster, Anna Williams
to
injury:
signalling
15* A zebrafish model of de- and remyelination
Marja Karttunen, Tim Czopka, Marieke Goedhart and David Lyons
16* Identifying chemical modulators of myelination in the zebrafish CNS
Jason Early, Charles ffrench-Constant, Robin J.M. Franklin, David A. Lyons
17
Discovery of new genes that regulate CNS myelination using a forward genetic screen
in zebrafish
Linde Kegel, Maria Rubio, Jill Williamson and David A Lyons
18
Synaptic vesicle release regulates the number of myelin sheaths made by individual
oligodendrocytes in vivo.
Sigrid Mensch, Marion Baraban, Rafael Almeida, Tim Czopka, Jessica Ausborn, Abdel El Manira and
David A Lyons.
19
Oligodendrocyte-innate programs dictate cell shape changes required to form myelin
sheaths and account for variation in lengths of CNS myelin sheaths
Marie E Bechler, Lauren Byrne, and Charles ffrench-Constant
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Cellular and Molecular
1* Role of LGI3 in organizing the juxtaparanodal domains of myelinated axons
Annelies van den Bogaard, M. Jaegle, Dies Meijer
20* The paranodal cytoskeleton in the formation and maintenance of nodes of Ranvier in
the CNS
Veronica Brivio, Diane L. Sherman, Elior Peles, Cathrine Faivre-Sarrailh and Peter J. Brophy
21* Studying glia-neuronal interaction in C9ORF72 expansion mediated amyotrophic lateral
sclerosis using an induced pluripotent stem cell based in vitro model
Chen Zhao, Bhuvaneish Thangaraj Selvaraj, Andrea Serio, Dario Magnani, Karen Burr, Elaine Evans,
Navneet Vasistha, David Story, Rickie Patani, Christopher E. Shaw Siddharthan Chandran
22* Defective axonal mitochondrial trafficking in a neuronal model of major mental illness.
Laura C. Murphy, Elise L.V. Malavasi, Helen S. Torrance, Paraskevi Makedonoupoulou, Hazel DavidsonSmith, Michel Didier, David J. Porteous, J. Kirsty Millar
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Studying the molecular consequences of a balanced translocation co-segregating with
major mental illnesses using family member derived iPSCs.
Makedonopoulou P., Grünewald E., Burr K., Navneet A. Vasistha, Porteous D.J., Blackwood D.H.,
Chandran S., McIntosh A.M., Millar J.K.
24* Epigenome-Wide Analysis of Methylation in a Family with a Balanced t(111)
Translocation Co-Segregating with Major Mental IllnessEpigenome-Wide Analysis of
Methylation in a Family with a Balanced t(111) Translocation Co-Segregating with
Major Mental Illness
McCartney DL, Walker RM, Blackwood DH, Millar JK, Thomson PA, McIntosh AM, McCombie WR,
Porteous DJ and Evans KL
25* The synaptome map of PSD95/Dlg4 is reorganised in mice carrying mutations
schizophrenia and intellectual disability genes PSD93/Dlg2 and SAP102/Dlg3.
Melissa Cizeron, Fei Zhu, Zhen Qiu, Greg Myles, Noboru H. Komiyama, Seth G.N. Grant
in
26* Super-Resolution Imaging of Genetically Targeted PSD95 in the Mouse Brain
Matthew Broadhead, Mathew H. Horrocks, F. Zhu, Noboru H. Komiyama, David G. Fricker, Maksym
Kopanitsa, Ruth Benavides-Piccione, Javier DeFilipe, Steven F.Lee, Seth G.N Grant
27* Mitochondria and synaptic stability
Laura C. Graham, Samantha L. Eaton, Douglas J. Lamont, Paula J. Brunton, Chris M. Henstridge, Tara
L. Spires-Jones, Thomas H. Gillingwater, Giuseppa Pennetta, Paul Skehel, Thomas M. Wishart
28* Nrf2 target genes can be controlled by neuronal activitiy in the absence of Nrf2 and
astrocytes
Nóra M. Márkus, Sudhir Chowdhry, John D. Hayes, Giles E. Hardingham
29* Presynaptic Deficits in a Mouse Model of Fragile X Syndrome
Bonnycastle KM, Marland JRK, Kind PC, Cousin MA
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Convergence of synaptic pathophysiology in the hippocampus of the Syngap+/- and
Fmr1-/y mice.
S. Barnes, A. D. Jackson, E. M. Osterweil, N. Komiyama, S. G. N. Grant, M. F. Bear, P. C. Kind, D. J. A.
Wyllie
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Microglial transcriptome diversity in the healthy adult brain and the impact of ageing
Kathleen Renault, Tom Michoel, Michail Karavalos, Mark Stevens, Tom Freeman, Kim Summers, Barry
McColl
32* Targeting ubiquitin pathways to develop treatments for spinal muscular atrophy.
Rachael A.Powis & Thomas H. Gillingwater
Neural Systems
2
Small-world structure induced by spike-timing-dependent plasticity in networks with
critical dynamics
Victor Hernandez-Urbina, J. Michael Herrmann
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33* Investigating the Activity of Hypothalamic Oxytocin
Gavage of Palatable Food
Catherine Hume, Nancy Sabatier, John Menzies & Gareth Leng
Neurons
in
Response
to
Oral
34* Melanocortin actions on oxytocin neurons
Luis Paiva, Mike Ludwig
35
The effects of insulin on mitral cells activity in the rat main olfactory bulb.
Eirini Papadaki, Gareth Leng, Mike Ludwig
36
Hippocampal inhibitory circuit dysfunction in a rodent model of Alzheimer’s disease
pathology
Rosalind Brown, Iris Oren
37* Hippocampal CA1 GABAergic
disease pathology
Keir Shaffick-Richardson, Iris Oren
synaptic
density
in
a
mouse
model
of
Alzheimer’s
Neuropathology and Degeneration
38* Elucidating the reversibility of ataxia as a basis for development of therapies
D. Suminaite, C. Lee, Y.L. Clarkson, E. M. Perkins, I. Monaghan and M.Jackson
39
Intrinsic SMN-dependent defects in Schwann cells from mice with
atrophy (SMA)
Gillian Hunter, Arwin Aghamalaky Sarvestany, Sarah Roche, Thomas Gillingwater
spinal
muscular
40
Differential Vulnerability of Motor Neurons
Atrophy
Natalie Courtney, Rashmi Kothary Lyndsay Murray
Spinal
Muscular
in
Mouse
Models
of
41* Synaptic pathology in a sheep model of Batten’s Disease
Ines S. Amorim, Thomas M. Wishart, Thomas H. Gillingwater
42* Identifying Potential Peripherally Accessible Biomarkers in Batten Disease
Maica Llavero Hurtado, Laura C. Graham, Thomas W. Marchant, Sam L. Eaton, Heidi R. Fuller, Amy
Tavendale, Paul Skehel, Douglas J. Lamont, Thomas H. Gillingwater, Jon D. Cooper, Thomas M.
Wishart
43
Harnessing the regenerative properties of inflammation to develop novel strategies for
perinatal brain repair in cerebral palsy
Graeme Ireland, Bobbi Fleiss, Julie-Clare Becher, David H. Rowitch, Colin Smith, Jane E. Norman,
Pierre Gressens, Jeffrey W. Pollard, Veronique E. Miron
44
The microenvironment of oligodendrocyte precursor cells in CNS regeneration
Eva Borger, Thomas Carr, Anna Williams
45* A murine model of self-limiting neuroinflammation
mechanism of inflammation resolution
Claire Davies, Neil Mabbott, Barry McColl
reveals
a
CCR2-independent
46
Regulation of microglial TREM expression and relevance to CNS injury and disease
Rosie Owens, Kathleen Renault, Claire Davies, Alessio Alfieri, Barry McColl
47
Multiple measures of oligomeric amyloid-beta at synapses
Eleanor K. Pickett, Robert M. Koffie, Susanne Wegmann, Chris Henstridge, Melissa Vaught, Roy
Soberman, Bradley T. Hyman, and Tara L. Spires-Jones
48
Contrasting models of misfolded protein transmission
Diack A, Ritchie D, Peden A, Brown D, Boyle A, Piccardo P, Ironside J, and Manson J
49* Utilisation of in-vitro models to facilitate the study of early mechanisms of misfolded
protein formation, accumulation and clearance
Declan King, Paul Skehel, Rona M Barron
50* Stable transfection of the prion protein gene into SH-SY5Y cells alters
responses in a clone-specific manner
Andrew R. Castle, Sonya Agarwal, Dominic Kurian, Thomas M. Wishart and Andrew C. Gill
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stress
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Prion protein protease sensitivity, stability and seeding activity in variably protease
sensitive prionopathy suggests molecular overlaps with sporadic Creutzfeldt-Jakob
disease
Alexander Peden, Deep Sarode, Carl Mulholland, Marcelo Barria, Diane Ritchie, James Ironside, Mark
Head
52
Human stem cell-derived astrocytes support the genotype-dependent replication of
variant Creutzfeldt-Jakob disease prions
Zuzana Krejciova, James Alibhai, Chen Zhao, Nina Rzechorzek, James Ironside, Jean Manson, Bilada
Bilican, Siddharthan Chandran, Mark Head
53
Amplification of PrPSc from fatal familial insomnia brain tissue using wild-type human
PrPC brain Substrate
Marcelo A Barria, Alexander H Peden, Richard Knight, James W Ironside, Rona Barron, Jean Manson,
and Mark W Head
54
Iatrogenic CJD in human growth hormone recipients in the UK
Diane L Ritchie, Alexander H Peden, Suzanne Lowrie, Margaret Le Grice, Kimberley Burns, Mark W
Head and James W Ironside
55
Pathological and biochemical investigation of a woman diagnosed
Creutzfeldt-Jakob disease shortly after parturition.
H.M.Yull, K.Toro, E.Keller, C.Rozsa, J.W.Ironside, G.G.Kovacs, and M W Head
56
Regulation of TREM receptor expression after experimental stroke: contrasting kinetics
and differential contributions of myeloid cell subsets
Alessio Alfieri, Claire Davies, Laura McCulloch, Barry McColl
57
Ischemic stroke induces a loss of innate-like functions of splenic marginal zone B
cells and susceptibility to bacterial pneumonia via β-adrenergic signalling
Laura McCulloch and Barry McColl
with
genetic
58* Is small vessel disease a disease of the blood brain barrier?
Rikesh M Rajani Delyth Graham, Anna F Dominiczak, Colin Smith, Joanna M Wardlaw, Anna Williams
59* Using induced pluripotent stem cell technology to understand
cytoskeletal dynamics in inherited retinal disease
Roly Megaw, Bal Dhillon, Alan Wright, Linda Lako, Charles ffrench-Constant
photoreceptor
Clinical
60* Apathy Profiles in Amyotrophic Lateral Sclerosis, Parkinson’s Disease and Alzheimer’s
Disease
Ratko Radakovic, John M. Starr, Richard Davenport, Sharon Abrahams
61* Prognostic relevance and oncogenic correlates of epilepsy and epilepsy treatment in
glioblastoma patients
Sharon Berendsen, Jérôme Kroonen, Meri Varkila, Tatjana Seute, Tom J. Snijders, Wim G.M. Spliet,
Christophe Poulet, Marie Willems, Marike Broekman, Vincent Bours, and Pierre A. Robe
62* Cerebral Oxygenation and Echocardiographic Parameters in Preterm Neonates with a
Patent Ductus Arteriosus
Laura Dix, Mirella Molenschot, Hans Breur, Willem de Vries, Daniel Vijlbrief, Floris Groenendaal, Frank
van Bel and Petra Lemmers
63
Anatomical inter-hemispherical distribution of small vessel disease markers after a
lacunar stroke
Xinyi Qiu, Maria C. Valdés Hernández, Xin Wang, Stewart Wiseman, Lucy C. Maconick, Fergus Doubal,
Cathy L.M. Sudlow and Joanna M. Wardlaw
64* Investigation of in-vivo glutamate concentrations in autism spectrum disorders with
single-voxel spectroscopy
Jennifer Siegel-Ramsay, Maria Dauvermann, Sarah Wright, Sonya Campbell, Holly Branigan, Andrew
Stanfield and Stephen Lawrie
65* Identifying early signs of the Fragile X-associated tremor ataxia syndrome: a cross
sectional study
Stephanie S. G. Brown and Andrew C. Stanfield
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66* Identifying endophenotypes for depression - a composite trait analysis
Lynsey S. Hall, Toni-Kim Clarke, Ana M. Fernandez-Pujals, Yan-Ni Zeng, Blair H. Smith, Lynne J.
Hocking, Sandosh Padmanabhan, Pippa Thomson, Caroline Hayward, Donald J. MacIntyre, Chris S.
Haley, David J Porteous, Ian J Deary, Andrew M. McIntosh
67
Polygenic risk for schizophrenia is associated with transition to disease in a familial
high risk sample
Catherine Bois, Toni-Kim Clarke, Lynsey Hall, Heather Whalley, Andrew MacIntosh, Stephen Lawrie
68* Polygenic risk for Schizophrenia is associated with increased Gyrification in a Familial
High Risk Cohort
Catherine Bois, Toni Kim Clarke, Lynsey Hall, Heather Whalley, Andrew Macintosh, Stephen Lawrie
Cognition
69* Behavioural Characterisation of a Potential
Disability and Autism
Jilly Hope, Jennifer Doig, Dinesh Soares, Cathy Abbott
70
Model
of
Severe
Intellectual
Genetic dissection of innate and adaptive mouse behaviour in 60 postsynaptic mutant
lines
Louie N. van de Lagemaat, Lianne E. Stanford, Charles Pettit, Kathryn Elsegood, David G. Fricker,
Ellie Tuck, Douglas J. Strathdee, Karen E. Strathdee, Jess Nithianantharajah, Noboru H. Komiyama,
and Seth G.N. Grant
71* The role of mineralocorticoid receptors
conditions in prenatally stressed rats
Yu-Ting Lai & Paula J. Brunton
72
Mouse
in
mediating
learning
under
stressful
Polygenic Risk Scores for Schizophrenia and Cognitive Decline over Old Age
Stuart J. Ritchie, Andrew M. McIntosh, Alexandra Bannach-Brown, Toni-Kim Clarke, Ian J. Deary
73* Structural network development and IQ during adolescence
Marinka M.G. Koenis, Rachel M. Brouwer, Suzanne C. Swagerman, Martijn P. van den Heuvel, René
C.W. Mandl, Inge L. C. van Soelen, René S. Kahn Dorret I. Boomsma, Hilleke E. Hulshoff Pol
74* Language learning as cognitive training: attentional improvement after a one-week
intensive Gaelic course
Madeleine R. Long, Mariana Vega-Mendoza, Antonella Sorace, Thomas H. Bak
3*
NEUROdevelopment in PReschool Children Of FIfe and Lothian
NEUROPROFILES – A population-based study
Matthew Hunter, Kirsten Verity, Ruth Sumpter, Michael Yoong, Richard Chin
Epilepsy
Study:
Techniques and Other
75* Development of a novel methodology for comparative morphometric analysis of the
mammalian neuromuscular junction
Ross A. Jones, Caitlan D. Reich, Fanney Kristmundsdottir, Gordon S. Findlater & Thomas H.
Gillingwater
76* Development of the highly versatile HALO
proteins
Max Kratschke, David Fricker and Seth G.N. Grant
tag
for
study
of
endogenous
synaptic
77
Quantitative imaging of tissue sections using infrared scanning technology
Samantha L Eaton, Elizabeth Cumyn, Declan King1 Rona Barron, Thomas M Wishart
78
Functional Magnetic Resonance Imaging in Intellectual Impairment and Autism
Spectrum Disorder
A.G. McKechanie, T.W.Moorhead, C.Thorburn, N.Roberts, E.C.Johnstone, D.G.C.Owens, A.C.Stanfield
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ModON: a Model Organism Network for everyone!
Nathalie A. Vladis
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FUSION: Art meets Neuroscience
Edinburgh Neuroscience and the Edinburgh College of Art have been working in partnership, since 2012,
bringing together staff and students in neuroscience, psychology and art. The following year we held a
series of laboratory residencies for ECA students and the resulting outputs were displayed at
Neuroscience Day 2013 as part of a student competition. Collaborations have continued and in October
2015 we launched a monthly art-neuroscience group, FUSION. This group allows people to meet in an
informal environment and, more recently, we have thoroughly enjoyed tours of the ECA studios and
Psychology laboratories. As a result, 3 regular FUSION asked to show some of their neuroscienceinspired work at Neuroscience Day 2105. Please take the time to chat to them – they are also looking
for a science space for a longer exhibition so let them know if you are interested!
Join FUSION on Facebook and Twitter: https://www.facebook.com/EdinburghFusion, @EdinUniFUSION
Visual Representations of Neuro-degeneration and Neuro-stimulation
Ellen Adams, 4th Year Painting Student at Edinburgh College of Art
My work this year stems from my curiosity about neuroscience due to my
physical condition gastroparesis, which is thought to be caused by nerve
damage. I am therefore interested in exploring visual representations of the
processes associated with neuro-degeneration and neuro-stimulation. So far I
have used a number of approaches including: three-dimensional sculptures which
have involved the manipulation of wire cabling and silk material; small and large
scale 2-D pen drawings on paper; subtle ghost-like embossings; paintings on
glass; and related photography. Some of these will be included in the FUSION
exhibition on the 4th March.
Minimal Occurrences
Beth Longmore, 4th Year Painting Student at Edinburgh College of Art
My practice is concerned with heightening our awareness of
minimal everyday occurrences, such as raindrops on a
window or the splatters of paint on a sideboard. I am
interested in rethinking the processes that caused them to
emerge through the creation of objects and film. The tools I
create in order to explore this often have a cyclical nature,
opening a space to question these markings rather than
aiming to change them. I hope to question the validity of
the information acquired from these invisible processes by
using ephemeral materials such as water or steam. The patterns created are illogical and are rarely
questioned in our everyday environment; through creating mechanisms I hope to inject some intention
into an ultimately purposeless outcome.
TELEPRESENT
Sky Su, 4th Year Sculpture at Edinburgh College of Art
I began my art practice this year intrigued by
neuroscientists’ research and experiments on ‘out-of-body’
experiences1.
I
was
particularly
interested
in
the
experimenters’ combined use of sight and touch—as well as
technology like virtual reality headsets and cameras—to
distort a participant’s in-body experience.
Wanting to explore how I feel moved when I see bodies in
motion (performed, virtual, or simply everyday), I create
digital mirrors for viewers to encounter and consider the
relationship with their own virtual, out-of-body self. Additionally, in working with this interactive art form, I
play with the idea of double consciousness—to simultaneously have access to two distinct fields
experiences: in an artwork and outside of it, in our bodies and out of them.
Bigna Lenggenhager, Tej Tadi, Thomas Metzinger, Olaf Blanke Video Ergo Sum: Manipulating Bodily SelfConsciousness and H. Henrik Ehrsson The Experimental Induction of Out-of-Body Experiences
1
Documentation of proposed work can be found here: cargocollective.com/skysu/Telepresent-Hands-Faces
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Poster Board Layout
Conference Centre Foyer Area (Ground Floor)
Great Hall and New Library Area (First Floor)
Posters:
Downstairs: 1- 40
Upstairs : 41 – 79
Poster manning times:
Coffee/Tea breaks: all
Even posters: 12.50 - 1.20 pm
Odd posters: 1.20 – 1.50 pm
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Neuroscience Day 2015 Attendees
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Delegate Name
Centre affiliation
Email
Mark Adams
Elliot Adams
Ellen Adams
Max Ahmed
Niya Aleksieva
Charis Alexakis
Alessio Alfieri
James Alibhai
Clara Alloza
Rafael Almeida
Ines Amorim
Sofia Anagianni
Vlad Anton
Daisy Arkell
Jon Bamber
Alexandra Bannach-‐Brown
Stephanie Barnes
Jane Barr
Marcelo Barria Matus
Amanda Barugh
Shinjini Basu
Marie Bechler
Catherine Becker
Thomas Becker
James Bednar
Silvia Benito
Sharon Berendsen
Matthew Bishop
Ellen Blackhouse
Catherine Bois
marion bonneau
Katherine Bonnycastle
Eva Borger
Amanda Boyd
penelope boyd
Aileen Boyle
Kalina Boytcheva
paul brennan
Caroline Brett
Veronica Brivio
Matt Broadhead
Ryan Broll
Peter James Brophy
Stephanie Brown
Rosalind Brown
Lindsey Caldwell
James Cameron
Marcos Cardozo
Thomas Carr
Andrew Castle
Wai Kit Chan
Stella Chan
Kelda Chia
Chih-‐Yuan Chiang
Richard Chin
Melissa Cizeron
Elaine Cleary
Mia Cokljat
Katy Cole
Natalie Courtney
Mike Cousin
Nelson Cowan
Sarah Cox
Hollie Craig
Psychiatry
Proteintech
Edinburgh College of Art
Honours Pharmacology
Neuroimaging Sciences
Roslin Institute
MSc Integrative Neuroscience
Institute for Adaptive and Neural Computation
National CJD Research & Surveillance Unit
Geriatric Medicine
Neuroinformatics DTC
Honours Neuroscience
Brain Centre Rudolf Magnus, Utrecht
Scottish Mental Health Research Network
Psychiatry
Institute for Genetics & Molecular Medicine
Centre for Multiple Sclerosis Research
Roslin Institute
Patrick Wild Centre
Anne Rowling Regenerative Neurology Clinic
Roslin Institute
Clinical Psychology
Muir Maxwell Epilepsy Centre
Psychology
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Christopher Crockford
Sally Cross
Katie D
joshua dacre
Claire Davies
Faith Davies
Sara Dawson
Victoria de Leeuw
Ian Deary
Sergio Della Sala
Rebecca Devon
Abigail Diack
Alessandra Dillenburg Scur
Kosala Dissanayake
Laura Dix
Paul Dudchenko
Barbara Duff
Jessica Duncombe
Leanne Duthie
Jason Early
Sam Eaton
Randall Engle
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Charles ffrench-‐Constant
Catriona Ford
valerio francioni
Berenice Gandit
Lisa Genzel
Klara Gerlei
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Jude Gibson
Jamie Gillies
Lindsey Gilling McIntosh
Thomas Gillingwater
Dr Christos Gkogkas
Pascal Goetghebeur
Alfredo Gonzalez Sulser
Katerina Gospodinova
Laura Graham
Seth Grant
Alison Green
Ewout Groen
Jane Haley
Lynsey Hall
Lloyd Hamilton
Giles Hardingham
Callista Harper
anjanette harris
Marie Harrisingh
Philip Hasel
Xin He
Mark Head
Katharina Heil
James Henderson
chris henstridge
Maria Hernandez
Victor Hernandez-‐Urbina
Leah Herrgen
J. Michael Herrmann
Laura Herrmann
Chiara Herzog
Matthew Hicks
Laura Hodges
Megan Holmes
jilly hope
Fiona Houston
Euan MacDonald Centre for MND Research
NHS Lothian
Roslin Institute
Proteintech
Human Cognitive Neuroscience
Roslin Institute
Psychiatry
Roslin Institute
Psychology
Psychiatry
Psychology
Takeda Cambridge
Honours Pharmacology
Roslin Institute
Edinburgh Neuroscience
Psychiatry
Institute of Adaptive & Neural Computation
Patrick Wild Centre
Institute of Perception-‐ Action and Behaviour
Institute for Perception-‐ Action and Behaviour
Uni Freiburg
Western General Hospital
Centre for Cadiovascular Sciences
Roslin Institute
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Graeme Ireland
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Adam Jackson
Rosemary Jackson
Andrew Jackson
Pooja Jain
Owen James
Aimun Jamjoom
Andrew Jarjour
Andrew Jarman
Izabela Jedrasiak
Robert Johnston
Mandy Johnstone
Anna Jones
Ross Jones
Mary Jones
Lydia Jones
Alexa Jury
Marin Ka Koenis
Marja Karttunen
Danai Katsanevaki
Linde Kegel
Alexandra Kelman
Emily Jing Min Khoo
Jee Soo Kim
Peter Kind
Declan King
Verity King
James Kirkpatrick
Rachel Kline
Y.K. Ko
Austin Koh
Alexandros Kokotos
Juraj Koudelka
Stella Kouloulia
Max Kratschke
Yu-‐Ting Lai
Amy Lam
Urte Laukaityte
Stephen Lawrie
Sarah Lempriere
Adriana Libori
Rena Liu
Maica Llavero-‐Hurtado
Amy Lloyd
Robert Logie
Madeleine Long
Beth Longmore
Darryl Low
Sara Lupo
David Lyons
Tom MacGillivray
Gale Maclain
Olivia Macquire
Sharan Mahtani
Vivek Majumder
ParaskeviI Makedonopoulou
Elise Malavasi
Clinical Psychology
Roslin Institute
Centre for Reproductive Health
The Wellcome Trust
Patrick Wild Centre
MRC-‐Human Genetics Unit
Brain Research Imaging Centre
Honours Medical Sciences
Patrick Wild Centre
Roslin Institute
Roslin Institute
Roslin Institute
BioQuarter Commercialisation
Philosophy
Psychiatry
Roslin Institute
Psychology
Psychology
Institute for Energy Systems
Royal College of Physicians of Edinburgh
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Daniel-‐Cosmin Marcu
Ramune Margeviciute
Maria Lopez Quiroga
Nora Markus
Grant Marshall
Henrik Martenzon
Katie Marwick
John Mason
Daniel Matterson
Kate McAllister
Tess McCann
Daniel McCartney
Christina McClure
Barry McColl
Laura McCulloch
Andrew McIntosh
Andrew McKechanie
Chris McNeill
Jamie McQueen
Roly Megaw
Dies Meijer
Joeri Meijsen
Sigrid Mensch
Xenios Milidonis
Kirsty Millar
Veronique Miron
Lindsay Mizen
Daisy Mollison
Vince Molony
Candice Morey
Richard Morris
Sarah Morson
Robin Morton
Laura Murphy
LYNDSAY Murray
Gregory Myles
Modestos Nakos Bibos
Emma Neilson
Lara Andrea Neira Gonzalez
Dr Kristin Nicodemus
Matthew Nolan
Grace O'Regan
Emily Ogden
Marlies Oostland
Iris Oren
Emily Osterweil
Luis Paiva
Claire Palacios
EIRINI PAPADAKI
Elisa Parish
Hannah Parkin
Thomas Pearson
Alexander Peden
Elitsa Peeva
Emma Perkins
Veselina Petrova
Pedro Piccardo
Eleanor Pickett
Jemma Pilcher
David Porteous
Lynn Powell
Rachael Powis
David Price
Jing Qiu
Ratko Radakovic
Rikesh Rajani
Roslin Institute
MRes Biomedical Research
Roslin Institute
Roslin Institute
Psychiatry
Patrick Wild Centre
Roslin Institute
Royal (Dick) Vet School
Psychology
Psychiatry
Centre for Genomics & Experimental Medicine
Roslin Institute
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Richard Ribchester
Katie Richards
Diane Ritchie
Craig Ritchie
Stuart Ritchie
Ana Maria Rondelli
Ally Rooney
Dylan Ross
Sanziana Rotariu
Mick Rudd
Silvie Ruigrok
Daniel Sakovics-‐Matutes
Peter Sandercock
Lorenzo Scanferla
Rosalie Schnoor
Matthias Schwannauer
Alina Schwarz
Luke Searcy
Robin Sellar
Marta Seretny
Keir Shaffick-‐Richardson
Fraser Shearer
Diane Sherman
YULU SHI
Mike Shipston
Hannah Shorrock
Jennifer Siegel
Konstanze Simbriger
Karamjit Singh
Keith Smith
Hannah Smith
Dinesh Soares
Tara Spires-‐Jones
Andrew Stanfield
Zuzanna Stawicka
Chloe Stephenson-‐Wright
Donal Stewart
Sky Su
Daumante Suminaite
Charlotte Sutherland
Matthew Swire
Dr Sergiy Sylantyev
Judi Syson
Zygimante Tarnauskaite
Thomas Theil
Sophie Thomson
Ariana Tiberi
Sally Till
Dong Tong
Megan Torvell
Themistoklis Tsarouchas
Jess Turnbull
Utibe-‐Abasi Udoh
Aqtar Ummar
Louie van de Lagemaat
Annelies van den Bogaard
Susan van Erp
Mark van Rossum
Covadonga Vara
Navneet Vasistha
Nathalie Vladis
Rosie Walker
Luke Walls
Catharine Ward Thompson
Amy Warnock
Claire Warren
Jemma Webster
Scottish Mental Health Research Network
Psychiatry
Institute of Perception, Action & Behaviour
UT Dallas
Human Cognitive Neuroscience
Clinical Psychology
Anaesthetics
Psychiatry
Alzheimer's Research Scotland
Patrick Wild Centre
Hinours Medical Sciences
Brain Research Imaging Centre
Honours Medical Sciences
Patrick Wild Centre
Institute of Adaptive & Neural Computation
OPENspace Research Centre, Edinburgh Colllege of Art
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Heather Whalley
Nicola Wheelan
Will Whiteley
Max Whittaker
Ella Wigmore
Anna Williams
Jill Williamson
Robin Willows Rough
Stewart Wiseman
Thomas Wishart
Emma Wood
Julie Woodfield
Alan Wright
Simiao Wu
David Wyllie
Yujie Yang
Joyce Yau
Kaiming Yin
alan yourell
Helen Yull
Eleni Zarogianni
Chen Zhao
Ahnjili ZhuParris
Huda Zoghbi
Petra zur Lage
Psychiatry
Psychiatry
Roslin Institute
MRC Human Genetics Unit
National CJD Research and Surveillance Unit
Psychiatry
HHMI/Baylor College of Medicine Centre for Integrative Physiology
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Wednesday 4 March 2015 - Edinburgh

Transcription

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